DEPT OF BIOCHEMISTRY
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| Project Title: | IHH regulating CDO/GAS1 function in synovial joint formation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V |
| Investigator(s): | Chan D, To MKT, Gao B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Establishment of a Transgenic Core Facility for generation of genetically modified mice |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Cheung J.P.Y., Kao P.Y.P., Sham P.C., Cheah K.S.E., Chan D., Cheung K.M.C. and Samartzis D., Etiology of developmental spinal stenosis: A genome-wide association study, Journal of Orthopaedic Research. 2017. |
| Researcher : Cheah KSE |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional Analyses of How Genomic Variation Affects Personal Risk for Degenerative Skeletal Disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 01/2018 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 12/2017 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Completion Date: | 12/2017 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| Project Title: | Sox9 control of neuromesodermal progenitors |
| Investigator(s): | Cheah KSE, Cheung MCH, Lian Q |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2017 |
| Project Title: | Molecular control of hypertrophic chondrocyte cell fate and lineage extension |
| Investigator(s): | Cheah KSE, Chan D, Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | 11th Molecular Biology of Hearing and Deafness Conference; From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2018 |
| Completion Date: | 05/2018 |
| List of Research Outputs |
| Cheung J.P.Y., Kao P.Y.P., Sham P.C., Cheah K.S.E., Chan D., Cheung K.M.C. and Samartzis D., Etiology of developmental spinal stenosis: A genome-wide association study, Journal of Orthopaedic Research. 2017. |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Outstanding Research Student Supervisor Award 2013-14 |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2014 |
| Project Title: | Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger |
| Investigator(s): | Jin D, Tse H |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein |
| Investigator(s): | Jin D, Yeung ML |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response |
| Investigator(s): | Jin D, Yang W, Deng J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2016 |
| Project Title: | Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases |
| Investigator(s): | Jin D, Deng J, Kong KY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Completion Date: | 03/2018 |
| Project Title: | Molecular Mechanism of PACT-dependent Innate Antiviral Response |
| Investigator(s): | Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| Project Title: | Perturbation of MAVS-dependent antiviral response by PB1-F2 protein of influenza A (H7N9) virus and implications to viral pathogenesis |
| Investigator(s): | Jin D, Chen H, Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Identification and characterization of MDM2 as an E3 ubiquitin ligase for STAT2 activated by Zika virus NS5 protein |
| Investigator(s): | Jin D, Yuen KS, Wang F |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Project Title: | Roles of BART non-coding RNAs in Epstein-Barr virus infection and oncogenesis (CRF) |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2017 |
| Project Title: | Cell Symposium: Neuro-Immune Axis: Reciprocal Regulation in Development, Health, and Disease; Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| Project Title: | Regulatory roles of WD40 repeat-containing protein 5 (WDR5) in hepatitis B virus transcription |
| Investigator(s): | Jin D, Kong KY, Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018. |
| Researcher : Kwok LF |
| List of Research Outputs |
| Lau Y.T., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design., Colloids Surf B Biointerfaces.. 2018, 162: 126-134. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Cell-based therapy for congenital myelin disorders of the central nervous system |
| Investigator(s): | Shum DKY, Chan YS, Shea GKH, Tu W, Tsui YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Lau Y.T., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design., Colloids Surf B Biointerfaces.. 2018, 162: 126-134. |
| Tsui Y.P., Shea G.K.H., Chan Y.S. and Shum D.K.Y., Derivation of Fate-Committed Schwann Cells from Bone Marrow Stromal Cells of Adult Rats., In: Paula V. Monje, Haesun A. Kim, Schwann Cells: Methods and Protocols. Springer, 2018, MIMB, volume 1739: 137-148. |