DEPT OF MICROBIOLOGY
| Researcher : Ahmed SS |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Researcher : Aw Yong KL |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Researcher : CHEN P |
| List of Research Outputs |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Cai J |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Researcher : Cao H |
| List of Research Outputs |
| Cao H., LAI Y., Salim B., XU Z. and Yan A., Comparative genome and transcriptome analysis reveals distinctive surface characteristics and unique physiological potentials of Pseudomonas aeruginosa ATCC 27853, BMC Genomics. 2017, 18. |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Researcher : Chan E |
| List of Research Outputs |
| Chan E., Paolo M.A.R.T.E.L.L.I., Hui S.W., Teng L.L., Lau S.K.P. and Woo P.C.Y., In Vitro Susceptibility Of Ceftolozane-tazobactam Against Burkholderia Pseudomallei , Antimicrobial Agents And Chemotherapy. 2018, 62. |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Chan G |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Researcher : Chan JFW |
| Project Title: | Characterization and determination of animal reservoirs of a novel animal flavivirus. |
| Investigator(s): | Chan JFW, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Completion Date: | 06/2018 |
| Project Title: | Efficacy and mechanistic evaluation of banana lectin (BanLec) as a novel pan-coronavirus antiviral agent: in-vitro and ex-vivo evidence |
| Investigator(s): | Chan JFW, Yeung ML, Chan KH |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Commissioned Study on Conducting Tests for Zika Virus among Asymptomatic People Returning from the 2016 Olympic Games and Paralympic Games |
| Investigator(s): | Chan JFW, Hung FNI, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Commissioned Research on Mental Health Policy and Services |
| Start Date: | 08/2016 |
| Project Title: | Repurposing clinically approved drugs as immediately available treatment options for the emerging Zika virus infection |
| Investigator(s): | Chan JFW, Yuan S |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| CHAUDHARY V., Yuen K.S., Chan J.F.W., Yuen K.Y. and Jin D., Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells., Cell Symposium on “Neuro-Immune Axis: Reciprocal regulation in development, health, and disease, Sitges, Spain, September 17-19, 2017.. 2017. |
| Chan J.F.W., Laboratory diagnosis of returning travellers from Brazil with suspected Zika virus exposure, Ad hoc clinical infection & public health forum on returning travelers and athletes from Brazil Olympics, Centre for Health Protection ICB / Hospital Authority IDCTC, Hong Kong. 2018. |
| Chan J.F.W., Sir Patrick Manson Gold Medal (for the best MD thesis in 2017), The University of Hong Kong. 2018. |
| Chan J.F.W., Top 1% scholar (2017), Clarivate Analytics (Thomson Reuters) Essential Science Indicators. 2017. |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Hung F.N.I., Tam A., Leong N., Chan J.F.W. and To K.K.W., Seven Years Follow-up of Combined Influenza and 23-valent Pneumococcal Polysaccharide Vaccine in Older Adults, 28th European Congress of Clinical Microbiology and Infectious Diseases, 21-24 April 2018. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Leong N., Tam A., Chan J.F.W., To K.K.W. and Hung F.N.I., The Characteristics and outcomes of human metapneumovirus infection in hospitalized older adults, 21-24 April 2018, 28th European Society of Clinical Microbiology and Infectious Diseases . 2018. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| Xing F., Ye H., Yang J., Chan J.F.W., Seto W.K.W., Pai M.C.P., Yuen K.Y. and Hung L.L., Fatal pancytopenia due to albendazole treatment for strongyloidiasis, IDCases. 2018, 12: 112-116. |
| Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Medical Mycology. 2017. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Chan KH |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Chiu S.S.S., Kwan Y.W., Feng S., Wong J.S.C., Leung C.W., Chan L.Y., Chan K.H., Ng T.K., To W.K., Cowling B.J. and Peiris J.S.M., Influenza vaccine effectiveness against influenza A(H3N2) hospitalizations in children in Hong Kong in a prolonged season, 2016/17., J Infect Dis.. Oxford University Press, 2018. |
| Cowling B.J., Wu P., Lo J.Y.C., Chan K.H., Chan L.Y., Fang J., So L.Y., Peiris J.S.M. and Chiu S.S.S., Population-based pediatric hospitalization burden of lineage-specific influenza B in Hong Kong, 2004–2014, Clinical Infectious Diseases. 2017, 65: 300-307. |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Leung N.H.L., Chu K.W., SHIU E.Y.C., Chan K.H., Hau B.J.P., Mcdevitt J.J., Yen H., Li Y., Ip D.K.M., Leung G.M., Peiris J.S.M., Seto W.H., Milton D.K. and Cowling B.J., Detection of respiratory viruses and efficacy of face masks in reducing viral release in human exhaled breath, 2nd International Meeting on Respiratory Pathogens. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| Yip C.Y., Sridhar S., Cheng A.K.W., Fung A.M.Y., Cheng C.C.V., Chan K.H. and Yuen K.Y., Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar ® HHV-6 PCR Kit for quantitative detection of human herpesvirus 6, Journal of Virological Methods. 2017, 246: 112-116. |
| Researcher : Chan WM |
| List of Research Outputs |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Chen H |
| Project Title: | Modification of cells for isolation and characterization of SARS CoV from animal sources |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 07/2004 |
| Project Title: | Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Antiviral drug resistance in H5N1 virus |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2007 |
| Project Title: | The role of RAP55 and P-bodies in the regulation of influenza virus replication |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Adaptive strategies of the H7N9 virus PB2 polymerase for replication in humans |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | the Sixth ESWI Influenza Conference I ; Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| List of Research Outputs |
| Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018. |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Chen H., Song W., Huang X., Wang P. and Mok B.W.Y., Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein, The 6th ESWI Influenza conference 2017. |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Li L., Shu Y., Guan Y., Feng Z., Yuen K.Y., Gao G.F., Yuan Z., Wang Y., Yu H., Wang D., Gao H., Wang C., Zheng S., Yang S., Yang W., Cao B., Chen H., Li Q., Zhu H., Zhou J., Liu D., Gao R., Wu N., Hu Y., Yao H., Zhang X., Yu L., Zheng S., Wu F., Lu H., Wang J., Xia S., Cui D., Bai T., Liang W., Lam T.Y., Wu G., Jie Z., Guo J., To K.K.W., Sheng J., Diao H., Xiang N., Yang Y., Zhao X., Tang L., Zhou S., Yu F. and Zhu D., National Grand Prize, 2017 National Science and Technology Progress Award, 国家科学技术进步奖特等奖, State Council of the People's Republic of China. 中华人民共和国国务院, 2018. |
| Li T., Guo X., Ji M., Li F., Wang H., Cheng W., Chen H., Ng M., Ge S., Yuan Y. and Xia N., Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma, Cancer Medicine. Malden, MA, USA, John Wiley & Sons Ltd, 2018, 7: 1458-1467. |
| Lin Q., Li T., Chen Y., Lau S.Y., Wei M., Zhang Y., Zhang Z., Yao Q., Li J., Li Z., Wang D., Zheng Q., Yu H., Gu Y., Zhang J., Chen H., Li S. and Xia N., Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus, Journal of Virology. Baltimore, USA, American Society for Microbiology, 2018, 92. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Ou H., Yao W., Yu D., Weng T., Wang F.X.C., Wu X., Wu H., Cheng L., Lu X., Wu N., Chen H., Li L. and Yao H., Longevity of protective immune responses induced by a split influenza A (H7N9) vaccine mixed with MF59 adjuvant in BALB/c mice, Oncotarget. Albany, N.Y., Impact Journals, 2017, 8: 91828-91840. |
| Shen C., Chen J., Li R., Zhang M., Wang G., Stegalkina S., Zhang L., Chen J., Cao J., Bi X., Anderson S.F., Alefantis T., Zhang M., Cai X., Yang K., Zheng Q., Fang M., Yu H., Luo W., Zheng Z., Yuan Q., Zhang J., Wai-Kuo Shih J., Kleanthous H., Chen H., Chen Y. and Xia N., A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses, Science Translational Medicine. Washington, DC, American Association for the Advancement of Science, 2017, 9: eaam5752. |
| Verhoeven R.J.A., TONG S., Zong J., Chen Y., Tsao G.S.W., Pan J. and Chen H., NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression, Cancers. Basel, Switerland, MDPI, 2018, 10(4): 119. |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Researcher : Chen HKJ |
| Project Title: | Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong |
| Investigator(s): | Chen HKJ, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 04/2009 |
| List of Research Outputs |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Ho P.L., Yau C.Y., Ho L.Y., Chen H.K.J., Lai E.L.Y., Lo W.U., Tse C.W. and Chow K.H., Rapid detection of cfiA metallo-β-lactamase-producing Bacteroides fragilis by the combination of MALDI-TOF MS and CarbaNP , Journal of Clinical Pathology. 2017, 70: 868-873. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Researcher : Chen JHK |
| Project Title: | Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong |
| Investigator(s): | Chen HKJ, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 04/2009 |
| List of Research Outputs |
| Researcher : Chen M |
| Project Title: | Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein |
| Investigator(s): | Chen M, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Researcher : Chen M |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Researcher : Chen Z |
| Project Title: | A novel model for the study of lung pathogenesis of SARS |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 08/2007 |
| Project Title: | Understanding the Ongoing HIV Epidemic in Yunnan China |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | China AIDS Initiative - General Award |
| Start Date: | 05/2008 |
| Project Title: | Preventing HIV-1 infection using a novel vaccine immunogen |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Global Health Grants |
| Start Date: | 10/2008 |
| Project Title: | Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 05/2011 |
| Project Title: | A Novel Vaccine for Mesothelioma Immunotherapy and Prevention; |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2011 |
| Project Title: | AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2011 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV. |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2012 |
| Project Title: | To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System |
| Investigator(s): | Chen Z, Liu L, Cheung KW, Du DY |
| Department: | Microbiology |
| Source(s) of Funding: | Guangdong-Hong Kong Technology Cooperation Funding Scheme |
| Start Date: | 07/2013 |
| Project Title: | To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System |
| Investigator(s): | Chen Z, Liu L, Cheung KW, Du DY |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2013 |
| Project Title: | Mechanism of potentiating HIV antigen-specific CD8+ T cells |
| Investigator(s): | Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2014 |
| Project Title: | A New Therapeutic Vaccine for HIV/AIDS |
| Investigator(s): | Chen Z, Cheung KW |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 12/2014 |
| Project Title: | Role of a newly identified PD-1 isoform in modulating immune responses |
| Investigator(s): | Chen Z, Cheung KLA |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | A New Therapeutic Vaccine for HIV/AIDS |
| Investigator(s): | Chen Z, Cheung KW |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 03/2015 |
| Project Title: | A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 04/2015 |
| Project Title: | Role of Δ42PD1 in HIV Infection |
| Investigator(s): | Chen Z, Cheung KLA |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention |
| Investigator(s): | Chen Z, Man K |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 09/2015 |
| Project Title: | Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression |
| Investigator(s): | Chen Z, Cheung KLA, Tan Z |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | A Therapeutic Bi-Specific Neutralizing Antibody for HIV/AIDS |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 01/2017 |
| Project Title: | Study on AIDS Vaccine and Immunotherapy |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | 醫療衛生三名工程 |
| Start Date: | 01/2017 |
| Project Title: | Potency of latency reversing drug combinations for purging HIV-1 reservoir of TGFβ1-induced resting CD4 T cells |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2018 |
| Project Title: | Structure-based vaccine design against HIV-1 |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Foundation for the National Institutes of Health (FNIH) |
| Start Date: | 04/2017 |
| Project Title: | Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention |
| Investigator(s): | Chen Z, Man K |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 05/2017 |
| Project Title: | Novel human neutralizing antibodies against HIV/AIDS |
| Investigator(s): | Chen Z, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2017 |
| Project Title: | 2017 CALDAR Summer Institute & International Global Health Conference; A Useful Humanized Mouse Model for HIV-1 Cure Research |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Completion Date: | 08/2017 |
| Project Title: | A Novel Therapeutic AAV-vectored Bi-Specific Neutralizing Antibody against HIV/AIDS |
| Investigator(s): | Chen Z, Tan Z |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2018 |
| Project Title: | A Novel PD1-based Vaccine for HIV/AIDS Immunotherapy |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 03/2018 |
| Project Title: | The role of a novel PD-1 isoform in regulating tumour-specific CD8+ T cell functions in hepatocellular carcinoma patients |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| Project Title: | Potentiating host immunity for HIV-1 functional cure (TRS) |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 04/2018 |
| Project Title: | Humanized Mouse Models for Infection and Cancer Research |
| Investigator(s): | Chen Z, Man K, Tsao GSW |
| Department: | Microbiology |
| Source(s) of Funding: | Platform Technology Funding |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Liu H., Liu X., Cheung K.L.A., Lo C.M., Chen Z. and Man K., Autophagy during cytomegalovirus infection shapes CD8+ T cell metabolism, Hong Kong Immunology Forum 2017, Hong Kong, China, 11 November 2017. |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Liu W., Wong Y.C. and Chen Z., T Cell Immunity Induced by Rhesus PD1-based DNA Vaccine Controls SHIV Infection in Rhesus Macaques, Australian Society for Microbiology Annual Scientific Meeting 2017. |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Yeung W.H.O., Liu L., Chen Z., Lo C.M. and Man K., Delta PD-1 expressed M2 macrophages promote liver tumor recurrence after transplantation, The 27th International Congress of The Transplantation Society, Madrid, Spain, 30 June - 5 July 2018. |
| Yeung W.H.O., Liu L., Chen Z. and Man K., Mentor Mentee Award , The Transplantation Society 2018 International Congress. 2018. |
| Yeung W.H.O., Liu L., Chen Z. and Man K., Rising Star Award, The 2018 Joint International Congress of ILTS, ELITA & LICAGE. 2018. |
| Yeung W.H.O., Liu L., Chen Z., Lo C.M. and Man K., Δ42PD-1 expressed M2 macrophages promoted tumor recurrence after liver transplantation, The 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018. |
| Researcher : Cheng CCV |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Yan C.H., Cheng C.C.V., Chan P.K., Fu C.H.H. and Chiu P.K.Y., A Randomized Controlled Trial on the Use of Body Exhaust System in Primary Total Knee Arthroplasty, American Academy of Orthopaedic Surgeons 2018 Annual Meeting. 2018. |
| Yan C.H., Cheng C.C.V., Chan P.K., Fu C.H.H., Cheung M.H.S. and Chiu P.K.Y., The use of body exhaust suit system in primary total knee arthroplasty: randomized controlled trials, 37th Hong Kong Orthopaedic Association Annual Congress. 2017. |
| Yip C.Y., Sridhar S., Cheng A.K.W., Fung A.M.Y., Cheng C.C.V., Chan K.H. and Yuen K.Y., Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar ® HHV-6 PCR Kit for quantitative detection of human herpesvirus 6, Journal of Virological Methods. 2017, 246: 112-116. |
| Researcher : Cheung KLA |
| Project Title: | Characterising the role of a novel PD1 isoform expressed on gamma-delta T cells in HIV-1 infection |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Liu H., Liu X., Cheung K.L.A., Lo C.M., Chen Z. and Man K., Autophagy during cytomegalovirus infection shapes CD8+ T cell metabolism, Hong Kong Immunology Forum 2017, Hong Kong, China, 11 November 2017. |
| Researcher : Cheung KW |
| List of Research Outputs |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Researcher : Chik KKH |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Researcher : Chiu MC |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Chiu TH |
| List of Research Outputs |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Researcher : Chow KH |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., Ho L.Y., Chen H.K.J., Lai E.L.Y., Lo W.U., Tse C.W. and Chow K.H., Rapid detection of cfiA metallo-β-lactamase-producing Bacteroides fragilis by the combination of MALDI-TOF MS and CarbaNP , Journal of Clinical Pathology. 2017, 70: 868-873. |
| Ho P.L., Yau C.Y., Ho L.Y., Lai E.L.Y., LIU C., Tse C.W. and Chow K.H., Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong by the tentative EUCAST disc diffusion method, Anaerobe. 2017, 47: 51-56. |
| Ho P.L., Yau C.Y., WANG Y. and Chow K.H., Determination of the mutation prevention concentration of imipenem for the two imipenem susceptible Bacteroides fragilis strains Q1F2 ( cfiA -positive) and ATCC 25282 ( cfiA -negative), International Journal of Antimicrobial Agents. 2017. |
| Researcher : Chow WN |
| List of Research Outputs |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Researcher : Chow WNF |
| List of Research Outputs |
| Hearn J., Chow W.N.F., Barton H., Tung M., Wilson P.J., Blaxter M., Buck A. and Little T.J., Daphnia magna microRNAs respond to nutritional stress and ageing but are not transgenerational , Molecular Ecology. 2018, 27: 1402-1412. |
| Researcher : Chu H |
| Project Title: | Investigating the role of caspase-6 in the replication of the Middle East respiratory syndrome coronavirus. |
| Investigator(s): | Chu H, Zhou J, Chan JFW, Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Investigating the role of necroptosis in MERS-CoV pathogenesis |
| Investigator(s): | Chu H |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : DISSANAYAKE DMTK |
| List of Research Outputs |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| Researcher : Dai J |
| List of Research Outputs |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Ding SY |
| List of Research Outputs |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| Researcher : FANG J |
| List of Research Outputs |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Researcher : Fan YY |
| List of Research Outputs |
| Woo P.C.Y., Martelli P., Hui S.W., Lau C.Y., Groff J.M., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Anaconda paramyxovirus infection in an adult green anaconda after prolonged incubation: Pathological characterization and whole genome sequence analysis, Infection, Genetics and Evolution. 2017, 51: 239-244. |
| Researcher : Fong HY |
| List of Research Outputs |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Researcher : Gao P |
| List of Research Outputs |
| Gao P., Davies J. and Kao R.Y.T., Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus, In: Victor J. Torres, mBio. 2017, 8. |
| Gao P. and Kao R.Y.T., Disarming the protective pigments of Staphylococcus aureus by a small molecule compound, The International Chemical Biology Society (ICBS) 2017. |
| Gao P., Ho P.L., Yan B., Sze K.H., Davies J. and Kao R.Y.T., Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences. 2018, 115: 8003. |
| WANG R., LAI T.P., Gao P., Zhang H.M., Ho P.L., Woo P.C.Y., Ma G.X., Kao R.Y.T., Li H. and Sun H., Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications. 2018, 9: 439. |
| Researcher : Guan Y |
| Project Title: | Vaccines for the control of H5N1 and other avian influenza viruses |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 04/2002 |
| Project Title: | Searching for the precursor of SARS-Cov in Southern China |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Special Research Achievement Award 2003-2004 |
| Investigator(s): | Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Special Research Achievement Award |
| Start Date: | 11/2004 |
| Project Title: | Partner State Key Laboratory of Emerging Infectious Diseases |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 02/2009 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 01/2013 |
| Project Title: | Outstanding Researcher Award 2013-14 |
| Investigator(s): | Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2014 |
| Researcher : Ho PL |
| Project Title: | A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae |
| Investigator(s): | Ho PL, Yuen KY, Que TL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2000 |
| Project Title: | Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada |
| Investigator(s): | Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2001 |
| Project Title: | Risk factors for SARS in health care workers following incubation of SARS patients |
| Investigator(s): | Ho PL, Hung CT |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae |
| Investigator(s): | Ho PL, Wong SSY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management |
| Investigator(s): | Ho PL, Yam WC, Leung CC, Yew WW, Mok YWT, Chan KS, Tam CM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2006 |
| Project Title: | Syndromic Surveillance and Modeling for Infectious Diseases |
| Investigator(s): | Ho PL, Wu JTK |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2013 |
| Project Title: | Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources |
| Investigator(s): | Ho PL, Lo WU |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | Development and validation of a MALDI-TOF based rapid test for detection of emerging carbapenem resistance in Bacteroides fragilis |
| Investigator(s): | Ho PL, Lo WU |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Completion Date: | 03/2018 |
| Project Title: | Unveiling the characteristics of emerging Staphylococcus lugdunensis sequence type 3 clone by genomics analysis |
| Investigator(s): | Ho PL, Sham PC, Lo WU |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Completion Date: | 04/2019 |
| Project Title: | 11th International Symposium on pneumococci & Pneumococcal diseases (ISPPD); Comparative genomic analysis of samples collected pre- and post- introduction of pneumococcal conjugative vaccine (PCV7) in Hong Kong. |
| Investigator(s): | Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2018 |
| Completion Date: | 04/2018 |
| Project Title: | Surveillance of antibiotic resistance genes in Hong Kong populations using metagenomics approaches |
| Investigator(s): | Ho PL, Cao H, Chow KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Gao P., Ho P.L., Yan B., Sze K.H., Davies J. and Kao R.Y.T., Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences. 2018, 115: 8003. |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., Ho L.Y., Chen H.K.J., Lai E.L.Y., Lo W.U., Tse C.W. and Chow K.H., Rapid detection of cfiA metallo-β-lactamase-producing Bacteroides fragilis by the combination of MALDI-TOF MS and CarbaNP , Journal of Clinical Pathology. 2017, 70: 868-873. |
| Ho P.L., Yau C.Y., Ho L.Y., Lai E.L.Y., LIU C., Tse C.W. and Chow K.H., Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong by the tentative EUCAST disc diffusion method, Anaerobe. 2017, 47: 51-56. |
| Ho P.L., Yau C.Y., WANG Y. and Chow K.H., Determination of the mutation prevention concentration of imipenem for the two imipenem susceptible Bacteroides fragilis strains Q1F2 ( cfiA -positive) and ATCC 25282 ( cfiA -negative), International Journal of Antimicrobial Agents. 2017. |
| Ho P.L., Justice of Peace, 非官守太平紳士, Chief Executive of Hong Kong Special Administrative Region. 香港特別行政區行政長官, 2017. |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| WANG R., LAI T.P., Gao P., Zhang H.M., Ho P.L., Woo P.C.Y., Ma G.X., Kao R.Y.T., Li H. and Sun H., Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications. 2018, 9: 439. |
| Researcher : Ho SF |
| List of Research Outputs |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Researcher : Ho TY |
| List of Research Outputs |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Researcher : Huang C |
| List of Research Outputs |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Researcher : Huang X |
| List of Research Outputs |
| Chen H., Song W., Huang X., Wang P. and Mok B.W.Y., Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein, The 6th ESWI Influenza conference 2017. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Huang Y |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Researcher : Hung FNI |
| Project Title: | Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial |
| Investigator(s): | Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure |
| Investigator(s): | Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial |
| Investigator(s): | Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 12/2014 |
| Project Title: | A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness |
| Investigator(s): | Hung FNI, Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Researcher : Hung LL |
| List of Research Outputs |
| Xing F., Ye H., Yang J., Chan J.F.W., Seto W.K.W., Pai M.C.P., Yuen K.Y. and Hung L.L., Fatal pancytopenia due to albendazole treatment for strongyloidiasis, IDCases. 2018, 12: 112-116. |
| Researcher : Im SWK |
| Project Title: | Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors |
| Investigator(s): | Im SWK, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Researcher : Jia L |
| List of Research Outputs |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Researcher : Kao RYT |
| Project Title: | Development of anti-virulence strategy by targeting the SaeS signaling system of Staphylococcus aureus |
| Investigator(s): | Kao RYT, Gao P |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | Structure and function study of Mp1p of pathogenic Talaromyces (Penicillium) marneffei: a novel virulence mechanism for the evasion of host defense |
| Investigator(s): | Kao RYT, Yuen KY, Sze KH |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2017 |
| List of Research Outputs |
| Gao P., Davies J. and Kao R.Y.T., Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus, In: Victor J. Torres, mBio. 2017, 8. |
| Gao P. and Kao R.Y.T., Disarming the protective pigments of Staphylococcus aureus by a small molecule compound, The International Chemical Biology Society (ICBS) 2017. |
| Gao P., Ho P.L., Yan B., Sze K.H., Davies J. and Kao R.Y.T., Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences. 2018, 115: 8003. |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Liao X.W., Yang F., WANG R., He X.J., Li H., Kao R.Y.T., Xia W. and Sun H., Identification of catabolite control protein A from Staphylococcus aureus as a target of silver ions , Chemical Science. Cambridge, UK, Royal Society of Chemistry, 2017, 8: 8061-8066. |
| Seneviratne C.J., Kao R.Y.T., Samaranayake L.P., Yuen K.Y., Yang D., WANG Y. and Wong S.W.S., Antifungal compounds and uses therof, US Patent No. 9,642,829 B2, issued on 9 May 2017. 2017. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| WANG R., LAI T.P., Gao P., Zhang H.M., Ho P.L., Woo P.C.Y., Ma G.X., Kao R.Y.T., Li H. and Sun H., Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications. 2018, 9: 439. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Researcher : Ke Y |
| List of Research Outputs |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Kok KH |
| Project Title: | Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis |
| Investigator(s): | Kok KH, Wong CM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity |
| Investigator(s): | Kok KH, Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Suppression of PACT-dependent antiviral response by measles virus V protein |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Innate immune sensing of rotavirus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | Functional role of PACT in limiting replication of influenza A virus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | A novel approach for the identification of N6-methyladenosine (m6A) RNA modification in human and viral mRNA |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | The role of ARRDC3 in the innate immune response to influenza A virus infection |
| Investigator(s): | Kok KH, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Functional role of an interferon-stimulated gene IFIRM in influenza A virus infection |
| Investigator(s): | Kok KH, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018. |
| Chan C.P., Kok K.H. and Jin D., Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia, 2017, 1018: 147-166. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855. |
| Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018. |
| Researcher : Kwok HY |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Researcher : LAM KS |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Researcher : LAW YT |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Researcher : LEE BK |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Researcher : LEUNG SS |
| List of Research Outputs |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Researcher : LI C |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : LIN Q |
| List of Research Outputs |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Researcher : LIU C |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., Ho L.Y., Lai E.L.Y., LIU C., Tse C.W. and Chow K.H., Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong by the tentative EUCAST disc diffusion method, Anaerobe. 2017, 47: 51-56. |
| Researcher : LIU H |
| List of Research Outputs |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : LIU S |
| List of Research Outputs |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Lai ELY |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., Ho L.Y., Chen H.K.J., Lai E.L.Y., Lo W.U., Tse C.W. and Chow K.H., Rapid detection of cfiA metallo-β-lactamase-producing Bacteroides fragilis by the combination of MALDI-TOF MS and CarbaNP , Journal of Clinical Pathology. 2017, 70: 868-873. |
| Ho P.L., Yau C.Y., Ho L.Y., Lai E.L.Y., LIU C., Tse C.W. and Chow K.H., Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong by the tentative EUCAST disc diffusion method, Anaerobe. 2017, 47: 51-56. |
| Researcher : Lam SF |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Researcher : Lau CY |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Woo P.C.Y., Martelli P., Hui S.W., Lau C.Y., Groff J.M., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Anaconda paramyxovirus infection in an adult green anaconda after prolonged incubation: Pathological characterization and whole genome sequence analysis, Infection, Genetics and Evolution. 2017, 51: 239-244. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| Researcher : Lau S.K.P. |
| Project Title: | Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Completion Date: | 08/2017 |
| Project Title: | Genomic characterization of a novel rat bocaparvovirus from Norway rats in China |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | 2nd International Symposium on Infectious Diseases of Bats 2017; Bats as possible animal origin of MERS-CoV |
| Investigator(s): | Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 07/2017 |
| Project Title: | Molecular diversity and evolution of bat alphacoronaviruses: implications on emergence potential and mechanism of interspecies transmission |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Researcher : Lau SKP |
| Project Title: | Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Completion Date: | 08/2017 |
| Project Title: | Genomic characterization of a novel rat bocaparvovirus from Norway rats in China |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | 2nd International Symposium on Infectious Diseases of Bats 2017; Bats as possible animal origin of MERS-CoV |
| Investigator(s): | Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 07/2017 |
| Project Title: | Molecular diversity and evolution of bat alphacoronaviruses: implications on emergence potential and mechanism of interspecies transmission |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Chan E., Paolo M.A.R.T.E.L.L.I., Hui S.W., Teng L.L., Lau S.K.P. and Woo P.C.Y., In Vitro Susceptibility Of Ceftolozane-tazobactam Against Burkholderia Pseudomallei , Antimicrobial Agents And Chemotherapy. 2018, 62. |
| Lau S.K.P., Associate Editor, Virology Journal (UK). 2018. |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Lau S.K.P., Editorial Board Member, Anaerobe (USA). 2018. |
| Lau S.K.P., Wong C.P., Lau T.C.K. and Woo P.C.Y., Molecular Evolution Of Mers Coronavirus: Dromedaries As A Recent Intermediate Host Or Long-time Animal Reservoir?, International Journal Of Molecular Sciences. 2017, 18: 2138. |
| Lau S.K.P., Molecular Research On Emerging Viruses: Evolution, Diagnostics, Pathogenesis, And Therapeutics, International Journal Of Molecular Sciences. 2018, 19: 398. |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Man M.Y., Shum H.P., Yan W.W. and Lau S.K.P., A case of Lemierre's syndrome in Intensive Care Unit, Indian Journal of Critical Care Medicine. 2018, 22: 122. |
| Man M.Y., Shum H.P., Chan Y.H., Chan K.C., Yan W.W., Lee R.A. and Lau S.K.P., Clinical Predictors And Outcomes Of Klebsiella Pneumoniae Bacteraemia In A Regional Hospital In Hong Kong, Journal Of Hospital Infection. 2017, 97: 35-41. |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Tsang C.C., Tang Y.M.J., Lau S.K.P. and Woo P.C.Y., Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – past, present and future, Computational and Structural Biotechnology Journal. 2018, 16. |
| Tsang K.L., Lee H.H., Yiu S.M., Lau S.K.P. and Woo P.C.Y., Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny, Scientific reports. 2017, 7: 4536. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Woo P.C.Y., Martelli P., Hui S.W., Lau C.Y., Groff J.M., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Anaconda paramyxovirus infection in an adult green anaconda after prolonged incubation: Pathological characterization and whole genome sequence analysis, Infection, Genetics and Evolution. 2017, 51: 239-244. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Medical Mycology. 2017. |
| Researcher : Lau SY |
| List of Research Outputs |
| Lin Q., Li T., Chen Y., Lau S.Y., Wei M., Zhang Y., Zhang Z., Yao Q., Li J., Li Z., Wang D., Zheng Q., Yu H., Gu Y., Zhang J., Chen H., Li S. and Xia N., Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus, Journal of Virology. Baltimore, USA, American Society for Microbiology, 2018, 92. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Lee CY |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Researcher : Lee HH |
| List of Research Outputs |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Tsang K.L., Lee H.H., Yiu S.M., Lau S.K.P. and Woo P.C.Y., Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny, Scientific reports. 2017, 7: 4536. |
| Researcher : Lee KC |
| List of Research Outputs |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Lee MY |
| Project Title: | Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer |
| Investigator(s): | Lee MY, Lok S, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 05/2009 |
| Project Title: | Innate lymphoid cell "adaptation" during influenza virus infection |
| Investigator(s): | Lee MY, Peiris JSM, Cowling BJ, Bruzzone R |
| Department: | School of Public Health |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2017 |
| Project Title: | Effect of Volatile Organic Compounds (VOCs) exposure on disease severity in influenza virus infection |
| Investigator(s): | Lee MY, Yan S |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Project Title: | Cytokines 2017; Influenza A H7N9 virus infects human brain astrocytes and neuronal cells and induces inflammatory immune responses |
| Investigator(s): | Lee MY |
| Department: | School of Public Health |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2017 |
| Completion Date: | 11/2017 |
| Researcher : Leung ASP |
| List of Research Outputs |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Leung KH |
| List of Research Outputs |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Researcher : Li C |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Li C |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Li J |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Researcher : Li KSM |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Researcher : Li TW |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Researcher : Liu L |
| Project Title: | Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong |
| Investigator(s): | Liu L |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 09/2009 |
| Project Title: | Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection |
| Investigator(s): | Liu L, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Completion Date: | 02/2018 |
| Project Title: | Defining the role of monocyte-derived dendritic cells in potentiating durable and protective T-cell immunity by a newly identified PD-1 isoform |
| Investigator(s): | Liu L, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | Mechanisms of viral evasion of vaccine induced T cell immune response |
| Investigator(s): | Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Completion Date: | 05/2018 |
| Project Title: | Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation |
| Investigator(s): | Liu L, Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| Project Title: | Role of Δ42PD-1 in B-cell dysfunction during HIV infection |
| Investigator(s): | Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | IMMUNOLOGY 2018; Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection |
| Investigator(s): | Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2018 |
| Completion Date: | 05/2018 |
| List of Research Outputs |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Yeung W.H.O., Liu L., Chen Z., Lo C.M. and Man K., Delta PD-1 expressed M2 macrophages promote liver tumor recurrence after transplantation, The 27th International Congress of The Transplantation Society, Madrid, Spain, 30 June - 5 July 2018. |
| Yeung W.H.O., Liu L., Chen Z. and Man K., Mentor Mentee Award , The Transplantation Society 2018 International Congress. 2018. |
| Yeung W.H.O., Liu L., Chen Z. and Man K., Rising Star Award, The 2018 Joint International Congress of ILTS, ELITA & LICAGE. 2018. |
| Yeung W.H.O., Liu L., Chen Z., Lo C.M. and Man K., Δ42PD-1 expressed M2 macrophages promoted tumor recurrence after liver transplantation, The 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018. |
| Researcher : Liu Y |
| List of Research Outputs |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Lo CS |
| List of Research Outputs |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Researcher : Lo WU |
| List of Research Outputs |
| Ho P.L., Yau C.Y., Ho L.Y., Chen H.K.J., Lai E.L.Y., Lo W.U., Tse C.W. and Chow K.H., Rapid detection of cfiA metallo-β-lactamase-producing Bacteroides fragilis by the combination of MALDI-TOF MS and CarbaNP , Journal of Clinical Pathology. 2017, 70: 868-873. |
| Researcher : Lu L |
| List of Research Outputs |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Researcher : Luk KH |
| List of Research Outputs |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Researcher : Mo Y |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Researcher : Mok BWY |
| Project Title: | The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response |
| Investigator(s): | Mok BWY, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Exploring the role of influenza virus NS1 in microRNA-mediated regulation of the innate immune response |
| Investigator(s): | Mok BWY, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Completion Date: | 12/2018 |
| List of Research Outputs |
| Chen H., Song W., Huang X., Wang P. and Mok B.W.Y., Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein, The 6th ESWI Influenza conference 2017. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Mok KY |
| List of Research Outputs |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Researcher : NG CK |
| List of Research Outputs |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Researcher : NIU M |
| List of Research Outputs |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Researcher : Ng CK |
| List of Research Outputs |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Researcher : Ng SP |
| Project Title: | Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli |
| Investigator(s): | Ng SP, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Environment Protection Department - General Award |
| Start Date: | 06/2001 |
| Researcher : Nishiura K |
| List of Research Outputs |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Researcher : PENG J |
| List of Research Outputs |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| Researcher : Peiris JSM |
| Project Title: | IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
| Investigator(s): | Peiris JSM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 04/2003 |
| Project Title: | Virus-cell interaction and the pathogenesis of SARS |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
| Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LML |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2003 |
| Project Title: | Outstanding Researcher Award 2003-2004 |
| Investigator(s): | Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 07/2004 |
| Project Title: | Special Research Achievement Award 2003-2004 |
| Investigator(s): | Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Special Research Achievement Award |
| Start Date: | 11/2004 |
| Project Title: | The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2005 |
| Project Title: | The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | The Wellcome Trust - General Award |
| Start Date: | 01/2007 |
| Project Title: | Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand) |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborating Project Fund |
| Start Date: | 06/2007 |
| Project Title: | Control of Pandemic and Inter-pandemic Influenza |
| Investigator(s): | Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL |
| Department: | Microbiology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Completion Date: | 12/2017 |
| Project Title: | Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis |
| Investigator(s): | Peiris JSM, Cowling BJ, Guan Y, Li Y, Nicholls JM, Poon LML, Tu W, Yen H, Zhu H, Chan MCW, Lam TY, Jin D, Lee MY, Sanyal S, Mok KP, Sham PC |
| Department: | School of Public Health |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Public Health Responses to threats of emerging, epidemic and endemic infectious diseases |
| Investigator(s): | Peiris JSM, Cowling BJ, Wu JTK, Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Commissioned Research on Control of Infectious Diseases (Phase III) |
| Start Date: | 01/2015 |
| Project Title: | Role of influenza virus surface glycoproteins in virus-induced cell stress and inflammation |
| Investigator(s): | Peiris JSM, Yen H |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Completion Date: | 10/2018 |
| Project Title: | HKU Centennial Distinguished Chinese Scholars Scheme 2015-16 |
| Investigator(s): | Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | HKU Centennial Distinguished Chinese Scholars Scheme |
| Start Date: | 09/2015 |
| Project Title: | Transmission of respiratory viruses: from basic science to evidence based options for control |
| Investigator(s): | Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 06/2017 |
| Researcher : Poon KM |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Poon LLM |
| Project Title: | Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome |
| Investigator(s): | Poon LML, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome |
| Investigator(s): | Poon LML |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2003 |
| Project Title: | Vaccination scheme development to stimulate both B and T cell dependent heterosubtypic protection against Influenza A viruses in mice |
| Investigator(s): | Poon LML, Doak SA |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Generation of a replication-incompetent NP-knockout influenza virus that allows expression of galactose-alpha-1,3-galactose (alpha-Gal) in infected cells to enhance adaptive immune response |
| Investigator(s): | Poon LML, Doak SA |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice |
| Investigator(s): | Poon LML, Doak SA |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 03/2019 |
| Project Title: | Dissecting the roles of influenza viral codon bias and CpG dinucleotide usage frequency on virus replication |
| Investigator(s): | Poon LML |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Outstanding Researcher Award 2016-17 |
| Investigator(s): | Poon LML |
| Department: | School of Public Health |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 01/2018 |
| Project Title: | Use of next-generation sequencing to dissect the role of influenza viral polymerase activity and fidelity on virus evolution and adaptation at the single-molecule level |
| Investigator(s): | Poon LML |
| Department: | School of Public Health |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2018 |
| Researcher : Poon WSR |
| List of Research Outputs |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Researcher : Siu GKH |
| List of Research Outputs |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Researcher : Smith GJ |
| Project Title: | Research into the ecology, evolution and population genetics of influenza A (H5N1) virus |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 05/2007 |
| Project Title: | Outstanding Young Researcher Award 2008-2009 |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2009 |
| Researcher : Song W |
| List of Research Outputs |
| Chen H., Song W., Huang X., Wang P. and Mok B.W.Y., Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein, The 6th ESWI Influenza conference 2017. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Researcher : Sridhar S |
| Project Title: | Clinical and virological features of chronic hepatitis E due to genotype 4 hepatitis E virus in immunocompromised patients |
| Investigator(s): | Sridhar S, Chan JFW, Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 09/2017 |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Gong W., Liu L., Li M., Wang L., Zhang M., Luo Z., Sridhar S., Woo P.C.Y. and Wang L., Evaluation of antiviral efficacy of Chinese traditional medicine Babao Dan in rabbits infected with hepatitis E virus, Journal of General Virology. 2018. |
| Sridhar S., Case Sharing Of Transfusion Transmitted Japanese Encephalitis . 2018. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| Sridhar S., Use of S17 fragment containing hepatitis E virus infectious clones in cell culture experiments: The fine print does matter, Journal of Viral Hepatitis. 2018. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Yip C.Y., Sridhar S., Cheng A.K.W., Fung A.M.Y., Cheng C.C.V., Chan K.H. and Yuen K.Y., Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar ® HHV-6 PCR Kit for quantitative detection of human herpesvirus 6, Journal of Virological Methods. 2017, 246: 112-116. |
| Researcher : Sze KH |
| Project Title: | XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy |
| Investigator(s): | Sze KH |
| Department: | Chemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA) |
| Investigator(s): | Sze KH, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Completion Date: | 02/2018 |
| Project Title: | System Biology investigation on virulence factors of methicillin-resistant Staphylococcus aureus (MRSA) |
| Investigator(s): | Sze KH, Yuen KY, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Host target characterizations for early secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB) |
| Investigator(s): | Sze KH, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Structure and function Investigation of pro-inflammatory lipid binding virulence factor of pathogenic Talaromyces marneffei |
| Investigator(s): | Sze KH, Yuen KY, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2017 |
| List of Research Outputs |
| Gao P., Ho P.L., Yan B., Sze K.H., Davies J. and Kao R.Y.T., Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences. 2018, 115: 8003. |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Researcher : TAM KGK |
| List of Research Outputs |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Researcher : TONG S |
| List of Research Outputs |
| Verhoeven R.J.A., TONG S., Zong J., Chen Y., Tsao G.S.W., Pan J. and Chen H., NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression, Cancers. Basel, Switerland, MDPI, 2018, 10(4): 119. |
| Researcher : Tam WT |
| List of Research Outputs |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| Researcher : Tan Z |
| Project Title: | Role of Δ42PD1/TLR4 interaction in human hepatocellular carcinoma and its blockade as a novel immunotherapy strategy |
| Investigator(s): | Tan Z, Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Completion Date: | 04/2019 |
| Project Title: | Combination of dendritic cell-based vaccination and immune checkpoint blockade for malignant mesothelioma immunotherapy |
| Investigator(s): | Tan Z, Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2017 |
| Researcher : Tang HY |
| List of Research Outputs |
| Liu L., PENG J., Tang H.Y., Kwok H.Y., Nishiura K., LIN Q., FANG J. and Chen Z., Aberrant innate immune activation facilitates EcoHIV evasion from vaccine-induced protection., IMMUNOLOGY 2018, Austin, USA (Oral Presentation). 2018. |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Researcher : Tang SF |
| List of Research Outputs |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Researcher : Tang Y |
| List of Research Outputs |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Researcher : Tang YMJ |
| List of Research Outputs |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Tsang C.C., Tang Y.M.J., Lau S.K.P. and Woo P.C.Y., Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – past, present and future, Computational and Structural Biotechnology Journal. 2018, 16. |
| Researcher : Teng LL |
| Project Title: | Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci |
| Investigator(s): | Teng LL, Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2006 |
| List of Research Outputs |
| Chan E., Paolo M.A.R.T.E.L.L.I., Hui S.W., Teng L.L., Lau S.K.P. and Woo P.C.Y., In Vitro Susceptibility Of Ceftolozane-tazobactam Against Burkholderia Pseudomallei , Antimicrobial Agents And Chemotherapy. 2018, 62. |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Researcher : To KKW |
| Project Title: | Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital |
| Investigator(s): | To KKW, Ho PL, Chan KH, Hung FNI, Chiu SSS |
| Department: | Microbiology |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 07/2011 |
| Project Title: | Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers |
| Investigator(s): | To KKW, Hung FNI, Yuen KY, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | Centre for Health Protection |
| Start Date: | 09/2013 |
| Project Title: | Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers (CHP-PH-11) |
| Investigator(s): | To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | Commissioned Project: Health and Medical Research Fund |
| Start Date: | 10/2013 |
| Project Title: | Rapid Molecular Diagnosis for Hospitalized Patients with Respiratory Tract Infection |
| Investigator(s): | To KKW, Hung FNI |
| Department: | Microbiology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2018 |
| Project Title: | 28th European Congress of Clinical Microbiology and Infectious Diseases; Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay |
| Investigator(s): | To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Hung F.N.I., Tam A., Leong N., Chan J.F.W. and To K.K.W., Seven Years Follow-up of Combined Influenza and 23-valent Pneumococcal Polysaccharide Vaccine in Older Adults, 28th European Congress of Clinical Microbiology and Infectious Diseases, 21-24 April 2018. |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Leong N., Tam A., Chan J.F.W., To K.K.W. and Hung F.N.I., The Characteristics and outcomes of human metapneumovirus infection in hospitalized older adults, 21-24 April 2018, 28th European Society of Clinical Microbiology and Infectious Diseases . 2018. |
| Li L., Shu Y., Guan Y., Feng Z., Yuen K.Y., Gao G.F., Yuan Z., Wang Y., Yu H., Wang D., Gao H., Wang C., Zheng S., Yang S., Yang W., Cao B., Chen H., Li Q., Zhu H., Zhou J., Liu D., Gao R., Wu N., Hu Y., Yao H., Zhang X., Yu L., Zheng S., Wu F., Lu H., Wang J., Xia S., Cui D., Bai T., Liang W., Lam T.Y., Wu G., Jie Z., Guo J., To K.K.W., Sheng J., Diao H., Xiang N., Yang Y., Zhao X., Tang L., Zhou S., Yu F. and Zhu D., National Grand Prize, 2017 National Science and Technology Progress Award, 国家科学技术进步奖特等奖, State Council of the People's Republic of China. 中华人民共和国国务院, 2018. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| To K.K.W., Management of beta-lactam allergic patients & experience sharing, Clinical Laboratory Allergy Meeting. 2017. |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| To K.K.W., Yip C.Y. and Yuen K.Y., Rhinovirus – From bench to bedside, Journal of the Formosan Medical Association. 2017, 116: 496-504. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Zhao H., To K.K.W. and Yuen K.Y., Nucleic Acid Molecules And Dual-functional Peptides Having Antiviral Activity And Delivery Activity, Compositions And Methods Thereof, University Of Hong Kong. 2018. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : To WCS |
| Project Title: | Pharmacogenomic and molecular epidemiological study of HIV/AIDS patients co-infected with Hepatitis C virus (HCV) |
| Investigator(s): | To WCS, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 10/2015 |
| Project Title: | Latent proviral DNA reservoir as a target for HIV-1 genotypic resistance and tropism analyses amoung HIV-1 patients with viremia or suppressed viral load |
| Investigator(s): | To WCS, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 10/2016 |
| List of Research Outputs |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Researcher : Tsang CC |
| Project Title: | 20th Congress of the International Society for Human and Animal Mycology; Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay |
| Investigator(s): | Tsang CC |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 07/2018 |
| List of Research Outputs |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Tsang C.C., Tang Y.M.J., Lau S.K.P. and Woo P.C.Y., Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – past, present and future, Computational and Structural Biotechnology Journal. 2018, 16. |
| Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Medical Mycology. 2017. |
| Researcher : Tsang KL |
| List of Research Outputs |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Tsang K.L., Lee H.H., Yiu S.M., Lau S.K.P. and Woo P.C.Y., Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny, Scientific reports. 2017, 7: 4536. |
| Researcher : Tse H |
| List of Research Outputs |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Researcher : Tsoi HW |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Researcher : Verhoeven RJA |
| List of Research Outputs |
| Verhoeven R.J.A., TONG S., Zong J., Chen Y., Tsao G.S.W., Pan J. and Chen H., NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression, Cancers. Basel, Switerland, MDPI, 2018, 10(4): 119. |
| Researcher : WANG D |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : WANG Y |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., WANG Y. and Chow K.H., Determination of the mutation prevention concentration of imipenem for the two imipenem susceptible Bacteroides fragilis strains Q1F2 ( cfiA -positive) and ATCC 25282 ( cfiA -negative), International Journal of Antimicrobial Agents. 2017. |
| Seneviratne C.J., Kao R.Y.T., Samaranayake L.P., Yuen K.Y., Yang D., WANG Y. and Wong S.W.S., Antifungal compounds and uses therof, US Patent No. 9,642,829 B2, issued on 9 May 2017. 2017. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : WANG Y |
| List of Research Outputs |
| Ho P.L., WANG Y., LIU C., Lai E.L.Y., LAW Y.T., Cao H. and Chow K.H., IncX3 Epidemic Plasmid Carrying bla NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China , Antimicrobial Agents and Chemotherapy. 2018, 62. |
| Ho P.L., Yau C.Y., WANG Y. and Chow K.H., Determination of the mutation prevention concentration of imipenem for the two imipenem susceptible Bacteroides fragilis strains Q1F2 ( cfiA -positive) and ATCC 25282 ( cfiA -negative), International Journal of Antimicrobial Agents. 2017. |
| Seneviratne C.J., Kao R.Y.T., Samaranayake L.P., Yuen K.Y., Yang D., WANG Y. and Wong S.W.S., Antifungal compounds and uses therof, US Patent No. 9,642,829 B2, issued on 9 May 2017. 2017. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : WONG HYB |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : WU X |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| WU X., Guo J., NIU M., An M., Liu L., Wang H., Jin X., Zhang Q., LAM K.S., Wu T., Wang H., Li J., Cheng L., Tang H.Y., Shang H., Zhang L., Zhou P. and Chen Z., Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. , J Clin Invest. 2018. |
| Researcher : Wang D |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Wang P |
| List of Research Outputs |
| Chen H., Song W., Huang X., Wang P. and Mok B.W.Y., Characterization of a newly emerged variant of H7N9 virus containing a polybasic motif in the hemagglutinin protein, The 6th ESWI Influenza conference 2017. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Researcher : Wen LR |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Wong CP |
| List of Research Outputs |
| Lau S.K.P., Wong C.P., Lau T.C.K. and Woo P.C.Y., Molecular Evolution Of Mers Coronavirus: Dromedaries As A Recent Intermediate Host Or Long-time Animal Reservoir?, International Journal Of Molecular Sciences. 2017, 18: 2138. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Researcher : Wong CYS |
| List of Research Outputs |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Researcher : Wong HYB |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Wong SC |
| List of Research Outputs |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Researcher : Wong SSY |
| Project Title: | Molecular characterization of streptococcus bovis bacteraemia |
| Investigator(s): | Wong SSY, Yuen KY, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification |
| Investigator(s): | Wong SSY, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Genome sequencing of clinical and environmental isolates of Burkholderia pseudomallei: implications for the most common sequence type circulating in Hong Kong |
| Investigator(s): | Wong SSY, Teng LL, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Completion Date: | 06/2018 |
| Project Title: | Prevalence of extended spectrum beta-lactamase (ESBL)-producing Laribacter hongkongensis in patients and freshwater fish in Hong Kong |
| Investigator(s): | Wong SSY, Teng LL, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Researcher : Wong TL |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Researcher : Wong YC |
| List of Research Outputs |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Liu W., Wong Y.C. and Chen Z., T Cell Immunity Induced by Rhesus PD1-based DNA Vaccine Controls SHIV Infection in Rhesus Macaques, Australian Society for Microbiology Annual Scientific Meeting 2017. |
| Wong Y.C., Young Investigator Award, Hong Kong Society for Immunology Forum . 2017. |
| Researcher : Wong YM |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| Researcher : Woo P.C.Y. |
| Project Title: | Infection and Immunology |
| Investigator(s): | Woo PCY, Yuen KY, Watt RM |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong |
| Investigator(s): | Woo PCY, Lau SKP, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Molecular Basis for Interspecies Transmission and Pathogenesis of Middle East Respiratory Syndrome Coronavirus |
| Investigator(s): | Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 11/2015 |
| Project Title: | Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines |
| Investigator(s): | Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei |
| Investigator(s): | Woo PCY, Lau SKP, Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories |
| Investigator(s): | Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2017 |
| Project Title: | 2nd International symposium on infectious diseases of bats 2017; Rapid detection of MERS coronavirus ancestors in bats |
| Investigator(s): | Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 07/2017 |
| Project Title: | Mechanistic study on the immune evasion of Talaromyces marneffei - conidial interaction with human macrophages and bronchial epithelial cells |
| Investigator(s): | Woo PCY, Lau SKP, Kok KH, Tsang CC |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Researcher : Woo PCY |
| Project Title: | Infection and Immunology |
| Investigator(s): | Woo PCY, Yuen KY, Watt RM |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong |
| Investigator(s): | Woo PCY, Lau SKP, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Molecular Basis for Interspecies Transmission and Pathogenesis of Middle East Respiratory Syndrome Coronavirus |
| Investigator(s): | Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 11/2015 |
| Project Title: | Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines |
| Investigator(s): | Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Completion Date: | 12/2017 |
| Project Title: | Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei |
| Investigator(s): | Woo PCY, Lau SKP, Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories |
| Investigator(s): | Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2017 |
| Project Title: | 2nd International symposium on infectious diseases of bats 2017; Rapid detection of MERS coronavirus ancestors in bats |
| Investigator(s): | Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 07/2017 |
| Project Title: | Mechanistic study on the immune evasion of Talaromyces marneffei - conidial interaction with human macrophages and bronchial epithelial cells |
| Investigator(s): | Woo PCY, Lau SKP, Kok KH, Tsang CC |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| Chan E., Paolo M.A.R.T.E.L.L.I., Hui S.W., Teng L.L., Lau S.K.P. and Woo P.C.Y., In Vitro Susceptibility Of Ceftolozane-tazobactam Against Burkholderia Pseudomallei , Antimicrobial Agents And Chemotherapy. 2018, 62. |
| Gong W., Liu L., Li M., Wang L., Zhang M., Luo Z., Sridhar S., Woo P.C.Y. and Wang L., Evaluation of antiviral efficacy of Chinese traditional medicine Babao Dan in rabbits infected with hepatitis E virus, Journal of General Virology. 2018. |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Teng L.L., Chiu T.H., Chan E., Tsang K.L., Gianni P.A.N.A.G.I.O.T.O.U., Zhai S.L. and Woo P.C.Y., Differential Microbial Communities Of Omnivorous And Herbivorous Cattle In Southern China, Computational And Structural Biotechnology Journal. 2018, 16: 54-60. |
| Lau S.K.P., Wong C.P., Lau T.C.K. and Woo P.C.Y., Molecular Evolution Of Mers Coronavirus: Dromedaries As A Recent Intermediate Host Or Long-time Animal Reservoir?, International Journal Of Molecular Sciences. 2017, 18: 2138. |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Teng L.L., Tang Y., Wong S.S.Y., Chiu T.H., Zhao Z.H.E., Chan E., Ngan A.H.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella Ocularis Sp. Nov. And Tsukamurella Hominis Sp. Nov., Isolated From Patients With Conjunctivitis In Hong Kong, International Journal Of Systematic And Evolutionary Microbiology. 2018, 68: 810-818. |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Tsang C.C., Tang Y.M.J., Lau S.K.P. and Woo P.C.Y., Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – past, present and future, Computational and Structural Biotechnology Journal. 2018, 16. |
| Tsang K.L., Lee H.H., Yiu S.M., Lau S.K.P. and Woo P.C.Y., Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny, Scientific reports. 2017, 7: 4536. |
| WANG R., LAI T.P., Gao P., Zhang H.M., Ho P.L., Woo P.C.Y., Ma G.X., Kao R.Y.T., Li H. and Sun H., Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nature Communications. 2018, 9: 439. |
| Wong C.Y.S., Sridhar S., Ngan A.H.Y., Chen H.K.J., Poon W.S.R., Lau S.K.P. and Woo P.C.Y., Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis, Mycopathologia. 2018, 183: 615-618. |
| Woo P.C.Y., Adult pneumococcal vaccination recommendation in Hong Kong: then and now, Taiwan adult pneumococcal disease expert meeting. 2017. |
| Woo P.C.Y., Martelli P., Hui S.W., Lau C.Y., Groff J.M., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Anaconda paramyxovirus infection in an adult green anaconda after prolonged incubation: Pathological characterization and whole genome sequence analysis, Infection, Genetics and Evolution. 2017, 51: 239-244. |
| Woo P.C.Y., Chronic pulmonary aspergillosis., Fourth Asia CARE Forum. 2017. |
| Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping., 19th International Conference on Virology, Singapore.. 2017. |
| Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Peking University Dean’s Forum. 2018. |
| Woo P.C.Y., Editorial Board member, Hong Kong Medical Journal . 2018. |
| Woo P.C.Y., Editorial Board member, PLoS One. 2018. |
| Woo P.C.Y., Editorial Board member, Scientific Reports . Scientific Reports, 2018. |
| Woo P.C.Y., Editors, Mycopathologia. 2018. |
| Woo P.C.Y., MERS: from Middle East to the East and beyond, 10th World Congress of The World Society for Pediatric Infectious Diseases. 2017. |
| Woo P.C.Y., Management of mucormycosis outbreak: from bench to bedside, International Congress of Chemotherapy and Infection. 2017. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| Woo P.C.Y., Novel hepatitis E viruses from camels: an emerging cause of hepatitis E virus infections in human, Global Chinese Association of Clinical Microbiology and Infectious Diseases Congress 2018. 2018. |
| Woo P.C.Y., Novel hepatitis E viruses from camels: an emerging cause of hepatitis E virus infections in human, Wildlife and Exotic Veterinary Medicine Conference 2018. 2018. |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| Yang X., KOOHIMOGHADAM M., WANG R., CHANG Y.Y., Woo P.C.Y., Wang J.W., Li H. and Sun H., Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials, PLOS Biology. 2018, 16: e2003887. |
| Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Medical Mycology. 2017. |
| Researcher : Wu T |
| List of Research Outputs |
| Cheung K.W., Wu T., Ho S.F., Wong Y.C., Liu L., Wang H. and Chen Z., α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection, Journal of Virology. 2018, 92: e01510-01517. |
| Researcher : XUE S |
| List of Research Outputs |
| Tsang C.C., Wernery U., Hebel C., Damerau A., Kinne J., Cai J., Kuespert H., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay, 20th Congress of the International Society for Human and Animal Mycology. 2018, 56: S147. |
| Researcher : Xiong L |
| List of Research Outputs |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Researcher : YANG D |
| List of Research Outputs |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Yam WC |
| Project Title: | Detection of HIV-1 minority drug-resistant and X4-tropic variants by Next-Generation Sequencing to improve the prediction of clinical antiretroviral treatment outcome |
| Investigator(s): | Yam WC, To WCS, Panagiotou I, Li J |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 04/2016 |
| List of Research Outputs |
| TAM K.G.K., LEUNG S.S., To W.C.S., Siu G.K.H., Lau C.K., Shek C.M., Tse W.Z., Wong S.S.Y., Ho P.L. and Yam W.C., Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay, Diagnostic Microbiology and Infectious Disease. 2017, 89: 118-124. |
| Researcher : Yan B |
| Project Title: | Metabolomics conference 2018; Untargeted Lipidomics Approach in the Characterization of Coronavirus 229E-Infected Huh7 Cells: lipid interaction of host cell and virus |
| Investigator(s): | Yan B |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Gao P., Ho P.L., Yan B., Sze K.H., Davies J. and Kao R.Y.T., Suppression of Staphylococcus aureus virulence by a small-molecule compound, Proceedings of the National Academy of Sciences. 2018, 115: 8003. |
| Researcher : Ye Z |
| Project Title: | 3rd Annual Congress on Infectious Diseases 2017; Isolation of the Monoclonal Antibody with High Antibody-Dependent CellMediated Cytotoxicity from the Hemagglutinin Head-region Epitope of Pandemic H1N1 Influenza Virus |
| Investigator(s): | Ye Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Completion Date: | 08/2017 |
| List of Research Outputs |
| Cheng Y., Wang F., Ye Z., Chan C.P., Chan C.P. and Jin D., Identification and characterization of a novel gene faci that alleviates highfat diet-induced metabolic syndrome in mice, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018. |
| Researcher : Yeung C |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Researcher : Yeung ML |
| Project Title: | Pathogenesis of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-associated renal failure |
| Investigator(s): | Yeung ML, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| List of Research Outputs |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Researcher : Yip CY |
| List of Research Outputs |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Sridhar S., Lo S.K., Xing F.F., Yang J., Ye H., Chan J.F.W., Teng L.L., Huang C., Yip C.Y., Lau S.K.P. and Woo P.C.Y., Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection, Emerging Microbes & Infections. 2017, 6: e115. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| To K.K.W., Yip C.Y. and Yuen K.Y., Rhinovirus – From bench to bedside, Journal of the Formosan Medical Association. 2017, 116: 496-504. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Yip C.Y., Sridhar S., Cheng A.K.W., Fung A.M.Y., Cheng C.C.V., Chan K.H. and Yuen K.Y., Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar ® HHV-6 PCR Kit for quantitative detection of human herpesvirus 6, Journal of Virological Methods. 2017, 246: 112-116. |
| Researcher : Yuan S |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Yuan S, Kao RYT, Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 07/2015 |
| Project Title: | 3rd Annual Congress on Infectious Diseases 2017; A novel small-molecule inhibitor of influenza A virus that acts by disrupting PB2 cap-binding of the viral polymerase |
| Investigator(s): | Yuan S |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Completion Date: | 08/2017 |
| List of Research Outputs |
| Yuan S., Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo., Antiviral Research. 2017. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Researcher : Yuen CKJ |
| Project Title: | Influenza 2018: Centenary of the 1918 Symposium; Quantitation of DI-RNA in H7N9 Influenza A Virus Infection |
| Investigator(s): | Yuen CKJ |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018. |
| Researcher : Yuen K.Y. |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Special Research Achievement Award 2003-2004 |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Special Research Achievement Award |
| Start Date: | 11/2004 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches |
| Investigator(s): | Yuen KY, Woo PCY, Lau SKP, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2018 |
| Project Title: | Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR |
| Investigator(s): | Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV |
| Department: | Microbiology |
| Source(s) of Funding: | Commissioned Research on Control of Infectious Diseases (Phase III) |
| Start Date: | 01/2015 |
| Project Title: | Research Output Prize (Faculty of Medicine) |
| Investigator(s): | Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH |
| Department: | Microbiology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 11/2016 |
| Project Title: | Research and Development of a Rapid Diagnostics and Antiviral Targets |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Respiratory Virus Research Foundation Limited |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Researcher : Yuen KY |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Special Research Achievement Award 2003-2004 |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Special Research Achievement Award |
| Start Date: | 11/2004 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches |
| Investigator(s): | Yuen KY, Woo PCY, Lau SKP, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2018 |
| Project Title: | Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR |
| Investigator(s): | Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV |
| Department: | Microbiology |
| Source(s) of Funding: | Commissioned Research on Control of Infectious Diseases (Phase III) |
| Start Date: | 01/2015 |
| Project Title: | Research Output Prize (Faculty of Medicine) |
| Investigator(s): | Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH |
| Department: | Microbiology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 11/2016 |
| Project Title: | Research and Development of a Rapid Diagnostics and Antiviral Targets |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Respiratory Virus Research Foundation Limited |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Aw Yong K.L., Yip C.C.Y., Sridhar S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Emergence of an interclade recombinant in enterovirus D68. (poster presentation), (Egmond aan Zee, the Netherlands) (Europic 2018). 2018. |
| CHAUDHARY V., Yuen K.S., Chan J.F.W., Yuen K.Y. and Jin D., Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells., Cell Symposium on “Neuro-Immune Axis: Reciprocal regulation in development, health, and disease, Sitges, Spain, September 17-19, 2017.. 2017. |
| Chan K.H., To K.K.W., Li T.W., Wong T.L., Zhang R., Chik K.K.H., Chan G., Yip C.Y., Chen H., Hung F.N.I., Chan J.F.W. and Yuen K.Y., Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates, Advances in Virology. New York, USA, Hindawi Pub. Corp., 2017, 2017: 1-8. |
| Chen H.K.J., Lam H.Y., Yip C.Y., Cheng C.C.V., Chan J.F.W., Leung T.H., Sridhar S., Chan K.H., Tang S.F. and Yuen K.Y., Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses, Diagnostic Microbiology and Infectious Disease. 2018, 90: 177-180. |
| Cheng C.C.V., Sridhar S., Wong S.C., Wong C.Y.S., Chan J.F.W., Yip C.Y., Chau C.H., Au T.W.K., Hwang Y.Y., Yau C.S.W., Lo J.Y.C., Lee C.K. and Yuen K.Y., Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China, Emerging Infectious Diseases. 2018, 24: 49-57. |
| Cheng C.C.V., Chen H., Wong S.C., Chen H.K.J., Ng W.C., So S.Y.C., Chan T.C., Wong C.Y.S., Ho P.L., Mody L., Chan F.H.W., Wong A.T.Y. and Yuen K.Y., Role of Hand Hygiene Ambassador and Implementation of Directly Observed Hand Hygiene Among Residents in Residential Care Homes for the Elderly in Hong Kong, Infection Control & Hospital Epidemiology. 2018, 39: 571-577. |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Lo C.S., Chow W.N., Fan R.Y.Y., Cai J., Yuen K.Y. and Woo P.C.Y., Novel Partitivirus Enhances Virulence Of And Causes Aberrant Gene Expression In Talaromyces Marneffei , mBio. 2018, 9. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Li L., Shu Y., Guan Y., Feng Z., Yuen K.Y., Gao G.F., Yuan Z., Wang Y., Yu H., Wang D., Gao H., Wang C., Zheng S., Yang S., Yang W., Cao B., Chen H., Li Q., Zhu H., Zhou J., Liu D., Gao R., Wu N., Hu Y., Yao H., Zhang X., Yu L., Zheng S., Wu F., Lu H., Wang J., Xia S., Cui D., Bai T., Liang W., Lam T.Y., Wu G., Jie Z., Guo J., To K.K.W., Sheng J., Diao H., Xiang N., Yang Y., Zhao X., Tang L., Zhou S., Yu F. and Zhu D., National Grand Prize, 2017 National Science and Technology Progress Award, 国家科学技术进步奖特等奖, State Council of the People's Republic of China. 中华人民共和国国务院, 2018. |
| Mok B.W.Y., LIU H., CHEN P., LIU S., Lau S.Y., Huang X., Liu Y., Wang P., Yuen K.Y. and Chen H., The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses, Microbes and Infection. The Netherlands, Elsevier, 2017, S1286-4579(17): 30142-9. |
| Poon W.S.R., Tam W.T., Lau S.K.P., Cheng C.C.V., Yuen K.Y., Schuster R.O.L.F. .K. and Woo P.C.Y., Molecular Identification Of Cestodes And Nematodes By Cox1 Gene Real-time Pcr And Sequencing, Diagnostic Microbiology And Infectious Disease . 2017. |
| Seneviratne C.J., Kao R.Y.T., Samaranayake L.P., Yuen K.Y., Yang D., WANG Y. and Wong S.W.S., Antifungal compounds and uses therof, US Patent No. 9,642,829 B2, issued on 9 May 2017. 2017. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Sridhar S., Yip C.Y., Chan J.F.W., To K.K.W., Cheng C.C.V. and Yuen K.Y., Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTi m e HCV Genotype II assay for hepatitis C genotyping, Diagnostic Microbiology and Infectious Disease. 2018, 91: 34-37. |
| Teng L.L., Martelli P., Chan W.M., Lee H.H., Hui S.W., Lau C.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Two novel noroviruses and a novel norovirus genogroup in California sea lions, Journal of General Virology. 2018, 99: 777-782. |
| To K.K.W., Ke Y., DISSANAYAKE D.M.T.K., Ding S.Y., Yip C.Y., Sze K.H. and Yuen K.Y., Lipidomics Analysis of Rhinovirus Infection in Human Airway Epithelial Cells, IDWeek 2017. |
| To K.K.W., Lu L., Fong H.Y., Wu A.K.L., Mok K.Y., Yip C.Y., Ke Y., Sze K.H., Lau S.K.P., Hung F.N.I. and Yuen K.Y., Rhinovirus Respiratory Tract Infection In Hospitalized Adult Patients Is Associated With T H 2 Response Irrespective Of Asthma, Journal of Infection. 2018, 76: 465-474. |
| To K.K.W., Yip C.Y. and Yuen K.Y., Rhinovirus – From bench to bedside, Journal of the Formosan Medical Association. 2017, 116: 496-504. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520. |
| Woo P.C.Y., Martelli P., Hui S.W., Lau C.Y., Groff J.M., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Anaconda paramyxovirus infection in an adult green anaconda after prolonged incubation: Pathological characterization and whole genome sequence analysis, Infection, Genetics and Evolution. 2017, 51: 239-244. |
| Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360. |
| Woo P.C.Y., Lau S.K.P., Chen Y., Wong Y.M., Chan K.H., Chen H., Zhang L., Xia N. and Yuen K.Y., Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin, Emerging Microbes & Infections. 2018, 7: 18. |
| XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195. |
| Xing F., Ye H., Yang J., Chan J.F.W., Seto W.K.W., Pai M.C.P., Yuen K.Y. and Hung L.L., Fatal pancytopenia due to albendazole treatment for strongyloidiasis, IDCases. 2018, 12: 112-116. |
| Yip C.Y., Sridhar S., Cheng A.K.W., Fung A.M.Y., Cheng C.C.V., Chan K.H. and Yuen K.Y., Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar ® HHV-6 PCR Kit for quantitative detection of human herpesvirus 6, Journal of Virological Methods. 2017, 246: 112-116. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Zhao H., To K.K.W. and Yuen K.Y., Nucleic Acid Molecules And Dual-functional Peptides Having Antiviral Activity And Delivery Activity, Compositions And Methods Thereof, University Of Hong Kong. 2018. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : ZHANG B |
| List of Research Outputs |
| XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195. |
| ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253. |
| Researcher : ZHAO X |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : ZHOU J |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Zhang H |
| Project Title: | the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice |
| Investigator(s): | Zhang H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2011 |
| Researcher : Zhang J |
| Project Title: | Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice |
| Investigator(s): | Zhang J, To KKW, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Project Title: | 8th Edition of International Conference on Infectious Diseases; High concentrations of PGE2 in diet-induced obese mice bestows the impaired innate immune responses to H1N1 influenza virus infection |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Researcher : Zhang JX |
| Project Title: | Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice |
| Investigator(s): | Zhang J, To KKW, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Project Title: | 8th Edition of International Conference on Infectious Diseases; High concentrations of PGE2 in diet-induced obese mice bestows the impaired innate immune responses to H1N1 influenza virus infection |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Researcher : Zhang M |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2011 |
| Researcher : Zhao H |
| Project Title: | 17th International Congress of Virology; IUMS Congresses 2017 in Singapore; Broadly antiviral peptide against respiratory viruses in vitro and in vivo |
| Investigator(s): | Zhao H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2017 |
| Completion Date: | 07/2017 |
| List of Research Outputs |
| Zhao H., To K.K.W. and Yuen K.Y., Nucleic Acid Molecules And Dual-functional Peptides Having Antiviral Activity And Delivery Activity, Compositions And Methods Thereof, University Of Hong Kong. 2018. |
| Researcher : Zhao S |
| List of Research Outputs |
| Lau S.K.P., Ahmed S.S., Tsoi H.W., Yeung C., Li K.S.M., Fan R.Y.Y., Zhao S., Lau C.Y., Lam S.F., Choi K.K.F., Chan B.C.H., Cai J., Wong S.S.Y., Chen H., Zhang H.A.I. .L.I.N., Zhang L.I.B.I.A.O., Wang M.I.N.G., Woo P.C.Y. and Yuen K.Y., Bats Host Diverse Parvoviruses As Possible Origin Of Mammalian Dependoparvoviruses And Source For Bat–swine Interspecies Transmission, Journal Of General Virology. 2017, 98: 3046-3059. |
| Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207. |
| Researcher : Zhao X |
| List of Research Outputs |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Zheng B |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| Project Title: | Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development |
| Investigator(s): | Zheng B, Chu H |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Researcher : Zheng B. |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| Project Title: | Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development |
| Investigator(s): | Zheng B, Chu H |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Project Title: | Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase |
| Investigator(s): | Zheng B, Kao RYT, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2015 |
| Researcher : Zhou J |
| Project Title: | A cell-based model to uncover the molecular underpinning of differential susceptibility and variable severity of human H7N9 influenza infection |
| Investigator(s): | Zhou J, Song Y, To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 08/2014 |
| Project Title: | Characterization of the immune activation pathway in human macrophage and the macrophage-neutrophil interaction in MERS coronavirus infection |
| Investigator(s): | Zhou J, Jin D, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| List of Research Outputs |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Zhou J., Li C., Sachs N., Chiu M.C., Wong H.Y.B., Chu H., Poon K.M., Wang D., Zhao X., Wen L.R., Song W., Yuan S., Wong K.K.Y., Chan J.F.W., To K.K.W., Chen H., Clevers H. and Yuen K.Y., Differentiated human airway organoids to assess infectivity of emerging influenza virus, Proceedings of the National Academy of Sciences. Washington, DC, USA, National Academy of Sciences, 2018, 115: 6822-6827. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |