School of Biomedical Sciences

SCHOOL OF BIOMEDICAL SCIENCES

Researcher : AN L

List of Research Outputs

AN L. and Huen M.S.Y., chromatin profiling of DNA damage response proteins reveals a role of RNF169 in single strand annealing repair, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : ARYA S

List of Research Outputs

ARYA S., mRNA vaccines for cancer, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

Researcher : Au YK

List of Research Outputs

PENG Y., Lv F., Au Y.K., Sun Y., Tam W.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Myofibroblast differentiation in disc degeneration: a possible contribution of local and non-local cells, ORS 4th International Spine Research Symposium, Philadelphia, USA. 2017.

Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.-.H., Wynn S., Mak A...C...Y..., Chan W...Y..., Jauch R., Fritzsch B., Lovell-Badge R., Sham M.H. and Cheah K.S.E., Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis, Molecular Biology of Hearing and Deafness 2018.

Researcher : BADEA S-R

List of Research Outputs

RUVEN C., BADEA S.-.R., Wong W.M. and Wu W., Combination Treatment With Exogenous GDNF and Fetal Spinal Cord Cells Results in Better Motoneuron Survival and Functional Recovery After Avulsion Injury With Delayed Root Reimplantation, Journal of Neuropathology & Experimental Neurology. 2018, 77: 325-343.

Researcher : Ballard HJ

Project Title:	Transmembrane-channel interactions in pre- and post-ischaemic cardioprotection
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	The role of cystic fibrosis transmembrane conductance regulator in the heart
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Ballard H.J., Exercise makes your brain bigger: skeletal muscle VEGF and hippocampal neurogenesis, The Journal of Physiology. UK, The Physiological Society, 2017, 595: 5721-5722.

Researcher : Bao S

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : CAO F

List of Research Outputs

CAO F., Podosomes as endocytosis sites of activated integrin receptors at the cell-matrix interface, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : CHAI S

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : CHAN CK

List of Research Outputs

CHAN C.K., Wong Y.S. and Lee C.W., Extracellular matrix protein-induced assembly of podosome-like structures for aneural acetylcholine receptor cluster remodeling, 37th Annual Scientific Meeting of the Australasian Neuroscience Society. 2017.

Researcher : CHAN HL

List of Research Outputs

CHAN H.L., Elucidating the Role of Kinesin Motor Protein KIF5B in Dendritic mRNA Transport and Synapse Development of Neuron (MPhil Thesis), The University of Hong Kong. 2017.

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

Researcher : CHAN LH

List of Research Outputs

Wong T.L., CHAN L.H. and Ma S.K.Y., Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2, AACR Annual Meeting 2017. 77(13 Suppl): Abstract nr 5416.

Researcher : CHAN MHM

List of Research Outputs

CHAN M.H.M., The interaction of berberine with chemodrugs for treating EBV-associated nasopharyngeal carcinomas (NPC) (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : CHAN SHV

List of Research Outputs

CHAN S.H.V., Functional Characterization of the Role of NIMA (never in mitosis gene a)-related kinase 2 (Nek2) in Hepatocellular Carcinoma (MPhil Thesis), The University of Hong Kong. 2018.

CHAN S.H.V., Chu K.M.J., Tse E.Y.T. and Ching Y.P., The Role of NEK2 on Chromosome Instability in Hepatocellular Carcinoma, European Molecular Biology Laboratory (EMBO) Conference/ Germany, Heidelberg . 2017.

Ching Y.P., CHAN S.H.V. and YEUNG S.F., The role of centrosome over-duplication in liver cancer , In: BIT, 15th Annual Congress of International Drug Discovery Science and Technology - Japan 2017 . Osaka Japan, 2017.

Researcher : CHAUDHARY V

List of Research Outputs

CHAUDHARY V., Modulation of interferon production and signaling by SFTS virus NSs protein and Zika virus NS5 protein (PhD Thesis), The University of Hong Kong. 2018.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Yuen K.Y. and Jin D., Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells., Cell Symposium on “Neuro-Immune Axis: Reciprocal regulation in development, health, and disease, Sitges, Spain, September 17-19, 2017.. 2017.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : CHE N

List of Research Outputs

CHE N., Tong M., Ng K.Y., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterization of PRMT6-Regulated Autophagy in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Researcher : CHEN L

List of Research Outputs

CHEN L., Sirt1 can act as a wider range deacylase, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : CHEN Y

List of Research Outputs

CHEN Y. and Huen M.S.Y., A Mechanistic Study of TRAIP Mobilisation in Replication Stress Response, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHEN Y., Nucleolar residence of the Seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : CHENG TF

List of Research Outputs

CHENG T.F., Caspase 3 activation and apoptosis facilitates primary infection of Epstein-Barr virus in HEK293 cells (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : CHEUNG PHH

List of Research Outputs

CHEUNG P.H.H., Chan C.P. and Jin D., To announce or not to announce: What is known about the 2016–2017 influenza season in Hong Kong?, Emerging Microbes & Infections. 2017, 6: e78.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018.

Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Researcher : CHEUNG WL

List of Research Outputs

CHEUNG W.L., Biomechanical regulation of stem cell behaviour in vivo, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : CHUA WH

List of Research Outputs

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Neonatal excitation-inhibition imbalance introduces long-lasting changes to neuronal recruitment in vestibular circuits for spatial navigation, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Rescuing developmental deficits in vestibular circuits by combined fluoxetine treatment and sensory training, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P13. 2018.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

Researcher : CHUNG WH

List of Research Outputs

CHUNG W.H., Breadth and selectivity of post-translational modification signaling: structural and chemical perspectives on protein functional machinery, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Wang Y., Jin J., CHUNG W.H., Feng L., Sun H. and Hao Q., Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation, Proceedings of the National Academy of Sciences. 2018, 115: 2365-2370.

Researcher : Cai S

List of Research Outputs

Cai S., Tsui Y.P., Tam K.W., Shea G.K.H., Chang R.S.K., Ao Q., Shum D.K.Y. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells, Stem Cell Reports. Cambridge, MA, Cell Press, 2017, 9: 1097-1108.

Cai S., Shea G.K.H., Shum D.K.Y. and Chan Y.S., Use of human iPSC-derived sensory neurons to switch human bone marrow-derived Schwann cells to fate commitment, Methods in Molecular Biology Series. 2018, 1739: 149-160.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells for use in transplantation therapy., Proc. 38^th Int’l Congress of International Union of Physiological Sciences 02.049. [Rio de Janeiro, Brazil. August 1-5, 2017]. 2017.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow - implications for remyelination therapy, Soc. Neuroscience Abstract (USA) 475.14. 2017.

Researcher : Chai S

List of Research Outputs

Researcher : Chan CP

List of Research Outputs

CHEUNG P.H.H., Chan C.P. and Jin D., To announce or not to announce: What is known about the 2016–2017 influenza season in Hong Kong?, Emerging Microbes & Infections. 2017, 6: e78.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018.

Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Chan C.P., Kok K.H. and Jin D., Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia, 2017, 1018: 147-166.

Cheng Y., Wang F., Ye Z., Chan C.P., Chan C.P. and Jin D., Identification and characterization of a novel gene faci that alleviates highfat diet-induced metabolic syndrome in mice, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Gao W., Tang H.M.V., Cheng Y., Chan C.P., Chan C.P. and Jin D., Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018, 1861: 211-223.

Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : Chan CP

Project Title:	Regulation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferase
Investigator(s):	Chan CP, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015
Completion Date:	12/2018

Project Title:	Antiviral activity of cGAS/cGAMP against RNA virus infection
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	01/2016
Completion Date:	02/2018

Project Title:	Characterization of a novel b-TrCP ubiquitin ligase-dependent mechanism for ubiquitination and degradation of liver-enriched transcription factor CREB-H
Investigator(s):	Chan CP, Yuen KS, Lui PY
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Science Fund for Young Scholars
Start Date:	01/2016

Project Title:	Roles of Middle East respiratory syndrome coronavirus ORF8b protein in Type I interferon antagonism
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	EMBO/EMBL Symposium Innate Immunity in Host-Pathogen Interactions; Double-stranded RNA-binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

CHEUNG P.H.H., Chan C.P. and Jin D., To announce or not to announce: What is known about the 2016–2017 influenza season in Hong Kong?, Emerging Microbes & Infections. 2017, 6: e78.

Chan C.P., Kok K.H. and Jin D., Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia, 2017, 1018: 147-166.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress
Investigator(s):	Chan D, Chan BP, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment
Investigator(s):	Chan D, To MKT
Department:	School of Biomedical Sciences
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2016

Project Title:	IHH regulating CDO/GAS1 function in synovial joint formation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V
Investigator(s):	Chan D, To MKT, Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Establishment of a Transgenic Core Facility for generation of genetically modified mice
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	04/2018

List of Research Outputs

Chan D., Cheung K.M.C., Leung V.Y.L. and Sun Y., Identification Of Small Molecule For Treating Intervertebral Disc Degeneration Via Interfering Proteoglycans Catabolic Degradation, Ors Psrs. 2017.

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Chan W.L., Steiner M., Witkos T., Egerer J., Busse B., Mizumoto S., Pestka J.M., Zhang H., Hausser I., Khayal L.A., Ott C., Kolanczyk M., Willie B., Schinke T., Paganini C., Rossi A., Sugahara K., Amling M., Knaus P., Chan D., Lowe M., Mundlos S. and Kornak U., Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica., PLOS Genet. 2018.

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Gao W.J., Chen C., Zhou T.F., Yang S.L., Gao B., Zhou H., Lian C.J., Wu Z.Z., Qiu X.J., Yang X.M., Alattar E., Liu W.T., Su D.Y., Chen Y.L., Song Y., Luk K.D.K., Chan D., Sham P.C., Xing C., Khor C.C., Liu G., Yang J.L., Deng Y.B., Hao D.J., Huang D.S., Li Q.Z., Xu C.X. and Su P.Q., Rare coding variants in mapk7 predispose to adolescent idiopathic scoliosis, Human Mutation. 2017, 38: 1500-1510.

LEUNG O.W. and Chan D., Implications of Gas1 in Synovial Joint Cavitation and Disease Mechanism of Brachydactyly A1, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15.

Tam V., Chan W.C.W., Leung V.Y.L., Cheah K.S.E., Cheung K.M.C., Sakai D., McCann M., Bedore J., Séguin C.A. and Chan D., Histological and reference system for the analysis of mouse intervertebral disc, Journal of Orthopaedic Research. 2017.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

WONG K.W., To M.K.T., Chan D. and Luk K.D.K., Role of IFITM5 c.-14C>T mutation in type V osteogenesis imperfecta, 2017.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Chan JLH

List of Research Outputs

Ng K.Y., Chan J.L.H., Chai S., Tong M., Guan X., Lee N.P.Y., Yuan Y.F., Xie D., Lee T.K., Dusetti N.J., Carrier A. and Ma S.K.Y., TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma, Cancer Research. 2017, 77(17): 4602-4612.

Researcher : Chan LK

Project Title:	Perception by LKS Faculty of Medicine graduates on their university education
Investigator(s):	Chan LK, Ip MSM, Patil NG, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	06/2008

Project Title:	Identifying the English language and communicative demands of bedside learning on students in the clinical years
Investigator(s):	Chan LK, Tse LK, Storey AM
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Medical Faculty Research Grant Fund
Start Date:	06/2008

Project Title:	Assessing competency of dental graduates from problem-based learning and traditional curriculums: Graduates’ and Employers’ Perceptions
Investigator(s):	Chan LK, Yiu CKY, Botelho MG, Bridges SM, Corbet EF, Dyson JE, McGrath CPJ, Wong RWK, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	12/2008

Project Title:	Designing technology-rich environments for case-based instruction: a model for life-long learning
Investigator(s):	Chan LK, Lu J
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	International Opportunities Fund
Start Date:	03/2010

Project Title:	Development of a fit-for-purpose Chinese-language course for the medical students
Investigator(s):	Chan LK, Soo YC, Tse SK
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Faculty Development Fund of Faculty of Medicine
Start Date:	06/2011

Project Title:	The use of mobile devices in problem-based learning
Investigator(s):	Chan LK, Bridges SM, Doherty I, Jin J, Ng ML
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	07/2013

List of Research Outputs

Bridges S.M., Chan L.K., Chen J.Y., Ganotice F.A. and Tsang J.P.Y., Interactional Dynamics in Interprofessional Team-Based Learning: Effects of Learning Design and Environments on Teamwork , 2018 Annual Meeting American Educational Research Association (AERA). 2018.

Chan L.K., Active learning pedagogies in anatomy. , Workshop organised by the HKU School of Professional and Continuing Education (SPACE), Institute for China Business.. 2018.

Chan L.K., An e-platform for promoting interprofessional team-based learning, TEAL (Technology Enhanced Active Learning) in Tertiary STEM education. Organised by Hong Kong Polytechnic University.. 2018.

Chan L.K., Breaking out of disciplinary silos - A team-based learning approach., Seminar of teaching and learning, Ajou University.. 2018.

Chan L.K., Faculty Education Programme (FEP) for Operation Theater Personnel, Hong Kong, Oct 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma,, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Hong Kong, Jun 2018, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2018.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Hong Kong, Oct 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Shanghai, China, July 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Shanghai, July 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Tokyo, Apr 2018, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2018.

Chan L.K., How to prepare novice anatomy teachers for teaching in the gross anatomy laboratory, The 25th International Symposium on Morphological Sciences and The 33th Annual Meeting of the Chinese Society of Anatomical Sciences (CSAS), Xi’an.. 2017.

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

Chan L.K., Principles of PBL, PBL workshop organized by the Institute of Professional Education, Hong Kong Baptist Hospital. 2017.

Chan L.K., Problem-Oriented Dissection: team exercises in the dissection laboratory, The 25th International Symposium on Morphological Sciences and The 33th Annual Meeting of the Chinese Society of Anatomical Sciences (CSAS), Xi’an.. 2017.

Chan L.K., Problem-based learning, Principles and implementation., Symposium of Medical Education Research, organized by Jinan University, Guangzhou, China. 2018.

Chan L.K., Promoting active learning in gross anatomy laboratory., The 61th Annual Conference of Korean Association of Physical Anthropologist, Jeonju, Korea.. 2018.

Chan L.K. and Wilson T., Publishing in Anatomical Sciences Education., Symposium of Medical Education Research, organized by Jinan University, Guangzhou, China.. 2018.

Chan L.K. and Ganotice F.J.A., Team size and cohesiveness affect achievements of interprofessional teams in team-based learning, Chinese University Medical Education Conference. 2018.

Chan L.K., Ganotice F.J.A. and Li Q., Team-based learning implemented on paper vs. electronic platform in an interprofessional programme in Hong Kong, Ninth Asia Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education . 2017.

Chan L.K. and Chan D.I.C.K., The Trek, 探, Hong Kong, brownie publishing, 2018.

Chan L.K., The use of technology to promote active learning in medicine., The 2nd International Conference on Digital Medicine. Guangzhou, China. 2018.

Chan L.K., Will Future Technology Replace the Biomedical Science Educator?, The 15th Asia Pacific Medical Education Conference. Singapore. 2018.

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A.F.Y., Wong J.Y.H., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Free Paper Presentation - Poster Audience Award, Asian Medical Education Association. 2017.

Chen J.Y., Chin W.Y., Chan L.K., Tsang J.P.Y. and Lau W.C.S., Stress and its effect on learning among first year healthcare professions students in Hong Kong, Hong Kong Mental Health Conference, Hong Kong Academy of Medicine. 2017.

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Stress and its impact on learning: a snapshot of first year health sciences students in the Li Ka Shing Faculty of Medicine, Ninth Asia Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education . 2017.

Chin W.Y., Chen J.Y., Chan K.H., Wan Y.F., Chan L.K. and Lau W.C.S., Mental And Physical Health Of Early To Mid-career Doctors In Hong Kong: A Cross-sectional Study, Australasian Doctors’ Health Conference . 2017.

Chin W.Y., Wan Y.F., Chan K.H., Chen J.Y., Chan L.K. and Lau W.C.S., Merit Award, Asian Medical Education Association (AMEA). 2017.

Chin W.Y., Wan Y.F., Chan K.H., Chen J.Y., Chan L.K. and Lau W.C.S., The Longitudinal Outcomes of HKU MBBS Students: A 20-year Retrospective Cohort Review., Asian Medical Education Association (AMEA) Conference 2017.

Ma C.W., Chan L.K., Lam I.H.Y. and Chan Y.S., Use of augmented reality to optimize the effectiveness of biomedical education, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education , PP55. 2017.

Pawlina W., Evans D.J.R., Chan L.K., Ruit K.G., Wilson T.D. and Lachman N., Student-teacher trust and journal-reader trust: Engines driving education and research in anatomical sciences (editorial), Anatomical Sciences Education . 2018, 11: 5-6.

Researcher : Chan WCW

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Tam V., Chan W.C.W., Leung V.Y.L., Cheah K.S.E., Cheung K.M.C., Sakai D., McCann M., Bedore J., Séguin C.A. and Chan D., Histological and reference system for the analysis of mouse intervertebral disc, Journal of Orthopaedic Research. 2017.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Chan WL

List of Research Outputs

Chan W.L., Lai W.L., SO P.Y. and Ching Y.P., Oncogenic role of CD133 in Hepatocellular Carcinoma, In: merican Association for Cancer Research (AACR), American Association for Cancer Research (AACR), Annual Meeting, Apr. 2018, Chicago, USA. 2018.

Researcher : Chan YS

Project Title:	30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2006

Project Title:	Role of the thalamus in integrating spatial information and guiding navigation
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Project Title:	Outstanding Research Student Supervisor Award 2009-10
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2010

Project Title:	Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Investigator(s):	Chan YS, Shum DKY, Lai CH
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Semaphorin and perineuronal nets regulate developmental plasticity of central vestibular circuitry
Investigator(s):	Chan YS, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015
Completion Date:	03/2018

Project Title:	Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Remodeling the sulfation pattern of perineuronal nets in the entorhinal cortical circuit prevents stress-induced decline in learning and memory
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	HKU Centennial Distinguished Chinese Scholars Scheme 2016-17
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:	09/2016

Project Title:	Selective recruitment of inhibitory interneurons to vestibular microcircuits for distinct behaviour
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2017

Project Title:	Overcoming hurdles in bridging critical nerve gaps to improve post-traumatic nerve regeneration and rehabilitation
Investigator(s):	Chan YS, Cai S, Shum DKY, Shea GKH, Tu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2018

Project Title:	Strategies to re-open plasticity in the central vestibular circuitry for rescuing disability in spatial learning (CRF)
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	04/2018

List of Research Outputs

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Neonatal excitation-inhibition imbalance introduces long-lasting changes to neuronal recruitment in vestibular circuits for spatial navigation, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Rescuing developmental deficits in vestibular circuits by combined fluoxetine treatment and sensory training, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P13. 2018.

Cai S., Tsui Y.P., Tam K.W., Shea G.K.H., Chang R.S.K., Ao Q., Shum D.K.Y. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells, Stem Cell Reports. Cambridge, MA, Cell Press, 2017, 9: 1097-1108.

Cai S., Shea G.K.H., Shum D.K.Y. and Chan Y.S., Use of human iPSC-derived sensory neurons to switch human bone marrow-derived Schwann cells to fate commitment, Methods in Molecular Biology Series. 2018, 1739: 149-160.

Chan R.W., LEONG T.L., Ho C.C., Gao P., WONG C.S., DONG M., WANG X., He J., Chan Y.S., Lim L.W. and Wu E.X., Low frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity. , Proceedings of the National Academy of Sciences. 2017.

Chan R.W., Leong A.T., Wong E.C., Ho L.C., Gao P.P., Dong C.M., Chan Y.S., Lim L.W. and Wu E.X., Low frequency hippocampal-cortical activity drives brain-wide resting-state functional connectivity: An optogenetic functional MRI study., Soc. Neuroscience Abstract (USA). 2017, 717: 04.

Chan Y.S., JIANG Q., Lai S.K., Wu L.K., Ma C.W. and Shum D.K.Y., Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation. Bulletin of Japan Soc Neurochemistry 56(2) : 119, [ 60^th Conference of Japan Society for Neurochemistry. Sendai, Japan. Sept. 7-9, 2017]. 2017.

Chan Y.S., KWAN P.Y., Ma C.W. and Shum D.K.Y., Emerging role of perineuronal chondroitin sulfates and semaphorin 3A on the developing vestibular circuitry, Proc. 1^st International Conference on the Glycobiology of Nervous System p.40 [BK21PLUS Lecture. Seoul, Korea. Sept. 2-5, 2017]. 2017.

Chan Y.S., Shi W., Wu L.K., Ma C.W. and Shum D.K.Y., Endocannabinoid-mediated modulation of sensorimotor circuits for the navigational system, [12^th Biennial Conference of Chinese Neuroscience Society. Tianjin Oct. 12-15, 2017]. 2017.

Chan Y.S., Impact of endocannabinoid on hardwiring of the circuit for spatial navigation. [Gordon Research Conference, Neuroplasticity and Maladaptation of Sensory Systems . Hong Kong. June 3-8, 2018]. 2018.

Chan Y.S., Han L., Li Y.H., Wu L.K. and Shum D.K.Y., Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors, Soc. Neuroscience Abstract (USA), 286.23 [Washington DC. Nov. 12-16, 2017]. 2017.

Chan Y.S., JIANG Q., Shi W. and Shum D.K.Y., The engagement of GABA receptors in tuning navigational behavior., [ 38^th Congress of International Union of Physiological Sciences Rio de Janeiro, Brazil. Aug. 1-5, 2017]. 2017.

Chow W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system., Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. 2017.

Han L. and Chan Y.S., Spontaneous transient outward currents in rat vestibular nucleus, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P47. 2018.

Ho S.N., Wu L.K., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Identification of perineuronal net-associated plastic factors, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P39. 2018.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 61. 2017.

JIANG Q., Wu L.K., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of your adult rats by fluoxetine, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P12. 2018.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. 2017.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 63. 2017.

Kwok L.F., Soo Z.K., Tam K.W., Shum D.K.Y. and Chan Y.S., Use of chondroitinase ABC-chitosan microbeads for treatment of spinal cord injury in rat, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P17. 2018.

Lam G., Shum D.K.Y., Chan Y.S. and Shea G.K.H., Transplantation of autologous human bone marrow-derived neural/glial progenitors in critical subacute window for repair of the injured spinal cord, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P16. 2018.

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Li Z.H., Chan Y.S. and Shum D.K.Y., Activity regulated neuronal trafficking of heparanase 1. Abstracts of 12^th Int’l Symp. on Healthy Aging, Science and Aging – Wellness and Longevity: From Science to Service : 50 [HK. March 11-12, 2017]. 2017.

Lyn Q., Fan R., Zhao J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization induced iPSC-derived cortical neurons through genome editing, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Ma C.W., Chu J.Y.S., Chan Y.S. and Shiu S.Y.W., Integrated life science education in Bachelor of Nursing and Bachelor of Chinese Medicine at The University of Hong Kong, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education, PP54. 2017.

Ma C.W., Chan L.K., Lam I.H.Y. and Chan Y.S., Use of augmented reality to optimize the effectiveness of biomedical education, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education , PP55. 2017.

Peng Y.J., Zheng C.X., Chen X., Han L., Li M., Zhang G., Jiang H., Chan Y.S., Lau G.C. and He J., CCK released by entorhinal cortical neurons enables visuo-auditory associative learning, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells for use in transplantation therapy., Proc. 38^th Int’l Congress of International Union of Physiological Sciences 02.049. [Rio de Janeiro, Brazil. August 1-5, 2017]. 2017.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow - implications for remyelination therapy, Soc. Neuroscience Abstract (USA) 475.14. 2017.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC treatment induces macrophage polarisation to anti-inflammatory state in central nervous system, 13th International Symposium on Healthy Aging “Aging‧Health‧Happiness” . 2018.

Tam K.W., Chan Y.S. and Shum D.K.Y., Macrophage polarisation to anti-inflammatory state in central nervous system after chondroitinase ABC treatment, 7 Lakes Proteoglycans International Conference. 2017.

Tipoe G.L., Lau C.S. and Chan Y.S., Integrated Basic Science and Inter-personal Education In Bachelor of Pharmacy at The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2017, 89.

Tipoe G.L., Lau C.S. and Chan Y.S., Integrated basic sciences and inter-professional education in Bachelor of Pharmacy at The University of Hong Kong, 9^th Asian Medical Education Association Conference, PP81. [HK. Dec 14-16, 2017]. 2017.

Tipoe G.L., Chan Y.S. and Lau C.S., Multiple pathways for Biomedical Sciences at the School of Biomedical Sciences, The University of Hong Kong, 9^th Asian Medical Education Association Conference, PP83. [HK. Dec 14-16, 2017]. 2017.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 81. 2017.

Tsui Y.P., Wu L.K., Chan Y.S. and Shum D.K.Y., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Abstracts of XIII European Meeting on Glial Cells in Health & Disease, GLIA 2017 ; T02-006A. Glia 65(S1) E116[Edinburgh. July 8-11, 2017]. 2017.

Wan V.W., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Assessing the role of inhibitory interneurons in motor learning., Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P6. 2018.

Wong C.N., Shum D.K.Y. and Chan Y.S., Effect of heparanase 2 protein on hippocampal neuron synaptic plasticity, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P4. 2018.

Yang B., Wong E., Ho W.H., Lau C., Chan Y.S. and Wu E.X., Reduction of sound-evoked midbrain responses observed by functional magnetic resonance imaging following acute acoustic noise exposure, Journal of Acoustical Society of America. 2018, 143: 2184.

Yip H.M., Kwok L.F., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cell-seeded chitosan nanofibers for nerve regeneration, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P14. 2018.

Researcher : Chang RCC

Project Title:	Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	03/2008

Project Title:	Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease
Investigator(s):	Chang RCC, Ng KM, Wang M, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015
Completion Date:	12/2018

Project Title:	Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models
Investigator(s):	Chang RCC, Hung HLC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015
Completion Date:	12/2018

Project Title:	Establishment of pre-clinical platform and a novel 3D tissue visualisation protocol for therapeutic drug development of Lewy Body Dementias
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2016

Project Title:	Significance of frontal cortex in the progression of Alzheimer’s disease
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	05/2018

Project Title:	Investigating the impact of periodontitis on neuroinflammation, neuropathology and neurodegeneration in Alzheimer's disease
Investigator(s):	Chang RCC, Khong PL, Leung WK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2017

Project Title:	Society for Neuroscience, USA; Neuroprotective effects of nicotinic receptor partial agonist varenicline in aged mice after laparotomy. Implication of therapeutic prevention of post-operative cognitive dysfunction
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2017
Completion Date:	11/2017

Project Title:	Investigating the significant roles of PKR on systemic inflammation triggered neuroinflammation and cognitive dysfunctions
Investigator(s):	Chang RCC, Mak HKF, Wong GTC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Investigating alpha-synuclein and tau in frontal cortex and hippocampus of experimental Parkinson’s disease dementia (PDD)
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2018

List of Research Outputs

HUANG C., Irwin M.G., Wong G.T.C. and Chang R.C.C., Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model, Journal of Neuroinflammation. 2018, 15: 147.

PANG C.C.C., Kiecker C., O’Brien J.T., Noble W. and Chang R.C.C., Ammon’s Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration, The Neuroscientist. 2018, 107385841877874.

Researcher : Chaudhary V

List of Research Outputs

CHAUDHARY V., Modulation of interferon production and signaling by SFTS virus NSs protein and Zika virus NS5 protein (PhD Thesis), The University of Hong Kong. 2018.

Researcher : Cheah KSE

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2010

Project Title:	Functional Analyses of How Genomic Variation Affects Personal Risk for Degenerative Skeletal Disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	01/2018

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	12/2017

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014
Completion Date:	12/2017

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Project Title:	Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
Investigator(s):	Cheah KSE, Wong YME, Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

Project Title:	Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2016

Project Title:	Sox9 control of neuromesodermal progenitors
Investigator(s):	Cheah KSE, Cheung MCH, Lian Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2017

Project Title:	Molecular control of hypertrophic chondrocyte cell fate and lineage extension
Investigator(s):	Cheah KSE, Chan D, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	11th Molecular Biology of Hearing and Deafness Conference; From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Cheah K.S.E., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, A research seminar in Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health & Manchester Academic Health Science Centre, The University of Manchester, UK. August 8, 2017. 2017.

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Cheah K.S.E., The integrated stress response – a double edged sword in skeletal development and disease, Cell Biology in Medicine Seminar Series, Cambridge Institute for Medical Research, University of Cambridge, UK. August 15, 2017. 2017.

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification Of Subpopulations And Molecular Signatures Of Enteric Neural Crest Via Single Cell Transcriptomics, Keystonesymposia T3: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering, Hong Kong, 15-19 Oct 2017.

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification of a novel enteric neural crest derived population in the developing mouse gut (Poster Presentation), The 5th International Symposium on Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy, Boston, U.S.A., 8-11 April 2018.

PENG Y., Lv F., Au Y.K., Sun Y., Tam W.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Myofibroblast differentiation in disc degeneration: a possible contribution of local and non-local cells, ORS 4th International Spine Research Symposium, Philadelphia, USA. 2017.

Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15.

Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.-.H., Wynn S., Mak A...C...Y..., Chan W...Y..., Jauch R., Fritzsch B., Lovell-Badge R., Sham M.H. and Cheah K.S.E., Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis, Molecular Biology of Hearing and Deafness 2018.

Tam V., Chan W.C.W., Leung V.Y.L., Cheah K.S.E., Cheung K.M.C., Sakai D., McCann M., Bedore J., Séguin C.A. and Chan D., Histological and reference system for the analysis of mouse intervertebral disc, Journal of Orthopaedic Research. 2017.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

ZHANG Z., Zhang Y., Gao F., HAN S., Cheah K.S.E., Tse H.F. and Lian Q., CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects, Molecular Therapy - Nucleic Acids. 2017, 9: 230-241.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Chen J

Project Title:	Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR
Investigator(s):	Chen J, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Investigating the mechanisms how Pseudomonas aeruginosa affects the function of airway epithelia
Investigator(s):	Chen J, Li NF, Wong PF
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Regional function around the F508 residue in protein processing and channel gating of CFTR
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Project Title:	Investigating the molecular mechanisms how Pseudomonas aeruginosa infection enhances the permeability of airway epithelia.
Investigator(s):	Chen J, Yan A
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

Researcher : Chen P

Project Title:	Single Cell Biology; An integrative bioinformatics approach for establishing transcriptomic identities of single-cell populations
Investigator(s):	Chen P
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2018
Completion Date:	03/2018

List of Research Outputs

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification Of Subpopulations And Molecular Signatures Of Enteric Neural Crest Via Single Cell Transcriptomics, Keystonesymposia T3: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering, Hong Kong, 15-19 Oct 2017.

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification of a novel enteric neural crest derived population in the developing mouse gut (Poster Presentation), The 5th International Symposium on Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy, Boston, U.S.A., 8-11 April 2018.

Researcher : Cheng Y

Project Title:	24th IUBMB Congress and 15th FAOBMB Congress; Identification and characterization of a novel gene Faci, which alleviates high-fat diet-induced metabolic syndrome in mice
Investigator(s):	Cheng Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

Cheng Y., Wang F., Ye Z., Chan C.P., Chan C.P. and Jin D., Identification and characterization of a novel gene faci that alleviates highfat diet-induced metabolic syndrome in mice, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Gao W., Tang H.M.V., Cheng Y., Chan C.P., Chan C.P. and Jin D., Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018, 1861: 211-223.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : Cheung A

Project Title:	Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer
Investigator(s):	Cheung A, Chan KW, Law SYK, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy
Investigator(s):	Cheung A, Li B
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	12/2017

Project Title:	Role and mechanism of serglycin in promoting esophageal cancer invasion and metastasis
Investigator(s):	Cheung A, Chan KW, Tsao GSW, Law SYK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	42nd FEBS Congress (from molecules to cells and back); Serglycin promotes invasion and metastasis of esophageal cancer
Investigator(s):	Cheung A
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	Significance of miR-338-5p in modulating PAK4 signaling and metastasis of esophageal cancer
Investigator(s):	Cheung A, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

Liu J., Lv L., Gong J., Tan Y., ZHU Y., Dai Y., Pan X., Huen M.S.Y., Li B., Tsao G.S.W., Huo J. and Cheung A., Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma, International Journal of Cancer. 2017.

Zhu Y., Li B., Xu W.W., Lam A.K.Y., Law S.Y.K. and Cheung A., Serglycin promotes migration and invasion of esophageal cancer cells, Proceedings of the Annual Meeting of the American Association for Cancer Research. 2018, 59: 811.

Researcher : Cheung KH

Project Title:	Role of TMEM16A in the formation of epididymal microenvironment
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Role of presenilin-1 in pancreatic beta-cell insulin secretion
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Researcher : Cheung MCH

Project Title:	In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2014
Completion Date:	09/2017

Project Title:	Elucidating the role of Sox9 in cell fate acquisition of neural crest progenitors in the dorsal root ganglia
Investigator(s):	Cheung MCH, Sham MH, Lui VCH, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Elucidating the therapeutic potential of neural stem cells with genetic manipulation of Sox9 expression following spinal cord injury
Investigator(s):	Cheung MCH, Wu W, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2016

Project Title:	Elucidating the role of Deleted in Liver Cancer-1 (DLC1) in melanoma development and therapy
Investigator(s):	Cheung MCH, Guan X
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	09/2018

Project Title:	Elucidating the role of DEPDC1B in melanoma development and therapy
Investigator(s):	Cheung MCH, Guan X
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2017

Project Title:	SOX9 is a dose-dependent oncogenic fate determinant in melanoma
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Hui M.N., Wu M.H. and Cheung M.C.H., Elucidating the roles of SOX9 in human neural stem cells., Keystone Symposium: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (T3). 2017.

RAO Y., Cheung M.P.L., Liu A.J., Sharma R. and Cheung M.C.H., A dual role for DLC1 in regulating avian cranial neural crest cell fate commitment and delamination, The Hong Kong Inter-University Postgraduate Symposium in Biomedical Sciences. 2018.

RAO Y., Cheung M.P.L. and Cheung M.C.H., Distinct modes of DLC1 function regulate avian cranial neural crest cell fate commitment and delamination, The 22nd Research Postgraduate Symposium, The University of Hong Kong. 2017.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

YANG X., Cheung M.P.L., Wong C.M., Ng I.O.L., Lung H.L. and Cheung M.C.H., Elucidating the role of DLC1, a RhoGTPase-activating protein, in metastatic melanoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Cheung MPL

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

RAO Y., Cheung M.P.L., Liu A.J., Sharma R. and Cheung M.C.H., A dual role for DLC1 in regulating avian cranial neural crest cell fate commitment and delamination, The Hong Kong Inter-University Postgraduate Symposium in Biomedical Sciences. 2018.

RAO Y., Cheung M.P.L. and Cheung M.C.H., Distinct modes of DLC1 function regulate avian cranial neural crest cell fate commitment and delamination, The 22nd Research Postgraduate Symposium, The University of Hong Kong. 2017.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

YANG X., Cheung M.P.L., Wong C.M., Ng I.O.L., Lung H.L. and Cheung M.C.H., Elucidating the role of DLC1, a RhoGTPase-activating protein, in metastatic melanoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Cheung WTL

Project Title:	PIK3R2 amplification in ovarian cancer: functional significance and implication for cancer therapy.
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	06/2016
Completion Date:	06/2018

Project Title:	Targeting PIK3R1 copy number loss in ovarian cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Characterization of PIK3R1 nSH2 domain mutations in cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Exploiting synthetic lethal interactions with EGFR inhibitor for translation to cancer therapies
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2017

Project Title:	Development of novel nanomedicine to enhance cancer chemotherapy response
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	Functional characterization of AKTIP in breast cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Aslan O., Cremona M., Morgan C., Cheung W.T.L., Mills G.B. and Hennessy B.T., Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro, BMC Cancer. 2018, 18.

Cheung W.T.L., 2017 USCACA & AFCR Scholar Awards, US Chinese Anti-Cancer Association (USCACA) Asian Fund for Cancer Research Limited (AFCR). 2017.

LI X., Mak C.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LI X., Mak C.Y., Zhou Y., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., PIK3R1 loss activates AKT and STAT3 signaling in ovarian cancer, American Association of Cancer Research Annual Meeting 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., PIK3R1 loss predicts sensitivity to AKT and STAT3 inhibitors in ovarian cancer, 2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., Targeting PIK3R1 loss by AKT and STAT3 inhibitors in ovarian cancer, 13th International Symposium on Healthy Aging. 2018.

Ng P.K., Li J., Jeong K.J., Shao S., Chen H., Tsang Y.H., Sengupta S., Wang Z., Bhavana V.H., Tran R., Soewito S., Minussi D.C., Moreno D., Kong K., Dogruluk T., Lu H., Gao J., Tokheim C., Zhou C., Johnson A.M., Zeng J., Ip C.K., Ju Z., Wester M., Yu S., Li Y., Vellano C.P., Schultz N., Karchin R., Ding L., Lu Y., Cheung W.T.L., Chen K., Shaw K., Meric-Bernstam F., Scott K.L., Yi S., Sahni N., Liang H. and Mills G.B., Systematic Functional Annotation of Somatic Mutations in Cancer, Cancer Cell. 2018, 33: 450-462.e10.

Researcher : Cheung YW

Project Title:	APTAMERS 2018 OXFORD; Aptamer selection using exotic nucleic acid for targeting Plasmodium falciparum lactate dehydrogenase
Investigator(s):	Cheung YW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Cheung Y.W., Wong A.W.C., Röthlisberger P., Hollenstein M. and Tanner J.A., Aptamer selection using exotic nucleic acid for targeting Plasmodium falciparum lactate dehydrogenase, Aptamer 2018, 5th Oxford Symposim on Aptamer. 2018.

Cheung Y.W., Wong A.W.C., Rothlisberger P., Hollenstein M. and Tanner J.A., Aptamer selection using exotic nucleic acid for targeting Plasmodium falciparum lactate dehydrogenase, Aptamers 2018, 5th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2018.

Cheung Y.W., Tanner J.A. and Kinghorn A.B., In: Julian A. Tanner, Andrew B. Kinghorn, Yee-Wai Cheung, International Journal of Molecular Sciences, Special Issue: Aptamer. 2017.

Figueroa M.G., Feng L., SHIU C.C., Dirkzwager R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhauser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017, University of Marburg, Germany. 2017.

Figueroa-Miranda G., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhausser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Sensors and Actuators B: Chemical. 2018, 255: 235-243.

JINATA C., Kinghorn A.B., Cheung Y.W. and Tanner J.A., Design, optimization, and application of a target-free immobilization DNA aptamer selection approach against fluorophores, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

LIU M., Yu Y.Y., Choi N.T.V., Cheung Y.W. and Tanner J.A., Inhibitory effects of apt21 and apt25 on the enzymatic activity of ADAMTS-5, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

Tanner J.A. and Cheung Y.W., Sandwich and species-specific nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis, PCT International Application. 2017.

Tucker W.O., Cheung Y.W., FRASER L.A., Kinghorn A.B. and Tanner J.A., Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1, International journal of molecular sciences. 2018, 19(3): 763.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP, Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015
Completion Date:	12/2018

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Characterization of novel HBx regulated gene in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	A study of the regulation of TAX1 binding protein 2 by p21-activated protein kinase 4 in liver cancer metastasis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2017

Project Title:	15th Annual Congress of International Drug Discovery Science and Technlogy ; The role of centrosome over-duplication in liver cancer
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2017
Completion Date:	07/2017

Project Title:	Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Investigator(s):	Ching YP, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Molecular mechanisms of Pumilio-Regulated Chromosomal Instability in Hepatocellular Carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

CHAN S.H.V., Chu K.M.J., Tse E.Y.T. and Ching Y.P., The Role of NEK2 on Chromosome Instability in Hepatocellular Carcinoma, European Molecular Biology Laboratory (EMBO) Conference/ Germany, Heidelberg . 2017.

Chan W.L., Lai W.L., SO P.Y. and Ching Y.P., Oncogenic role of CD133 in Hepatocellular Carcinoma, In: merican Association for Cancer Research (AACR), American Association for Cancer Research (AACR), Annual Meeting, Apr. 2018, Chicago, USA. 2018.

Ching Y.P., Multiple mechanisms of HBx in promoting chromosome instability, In: Croucher Foundation , Croucher Summer Course in Cancer Biology 2017. 2017.

Ching Y.P., CHAN S.H.V. and YEUNG S.F., The role of centrosome over-duplication in liver cancer , In: BIT, 15th Annual Congress of International Drug Discovery Science and Technology - Japan 2017 . Osaka Japan, 2017.

YEUNG S.F., Lai W.L. and Ching Y.P., The role of centrosome amplification in HCC, In: AACR, American Association for Cancer Research (AACR), Annual Meeting, April, 2018, Chicago, USA. 2018.

Researcher : Choi NTV

List of Research Outputs

LIU M., Yu Y.Y., Choi N.T.V., Cheung Y.W. and Tanner J.A., Inhibitory effects of apt21 and apt25 on the enzymatic activity of ADAMTS-5, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG W., Garrett L., FENG D., Elliott G., Liu X., WANG N., Wong Y.M., Choi N.T.V., Yang Y. and Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Chow WH

List of Research Outputs

Chow W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system., Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. 2017.

Researcher : Chu JYS

List of Research Outputs

Ma C.W., Chu J.Y.S., Chan Y.S. and Shiu S.Y.W., Integrated life science education in Bachelor of Nursing and Bachelor of Chinese Medicine at The University of Hong Kong, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education, PP54. 2017.

Researcher : Chu KMJ

Project Title:	EMBO Conference: Centrosomes and Spindle Pole Bodies; To study the effect of NEK2 on chromosome instability in hepatocellular carcinoma
Investigator(s):	Chu KMJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

List of Research Outputs

CHAN S.H.V., Chu K.M.J., Tse E.Y.T. and Ching Y.P., The Role of NEK2 on Chromosome Instability in Hepatocellular Carcinoma, European Molecular Biology Laboratory (EMBO) Conference/ Germany, Heidelberg . 2017.

Researcher : Chung SK

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012
Completion Date:	08/2017

Project Title:	To determine the role of Exchange Proteins Directly Activated by cAMP (Epac) in the gut microbiota-mediated metabolic syndrome
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	To determine the role of exchange protein directly activated by cAMP in the blood-retinal barrier and pathogenesis of diabetic retinopathy
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Interaction between activated aldose reductase, non-enzymatic glycation, PKC and hexosamine pathways for the pathogenesis of diabetic complications
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

List of Research Outputs

Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors, Acta Pharmacologica Sinica. 2017, 38: 1699-1700.

Durairajan S.S.K., Lyaswamy A.H., Shetty S.G., Malampati S.D., Shang W.B., Yang C.B., Song J.X., Chung S.K., Huang J., Ilango K., Han Q.B. and Li M., A modified formulation of Huanglian-Jie-Du Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease, Scientific Reports. 2017, 7: 6238.

LIAO B., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein mediates ischemic stroke, Mini-symposium on brain and adipose tissue crosstalk 2017. 2017.

Li Y., Song J., Tong Y., Chung S.K. and Wong Y.H., RGS19 upregulates Nm23-H1/2 metastasis suppressors by transcriptional activation via the cAMP/PKA/CREB pathway, Oncotarget. 2017.

Liu X., Lo C.M., Cheng Q., Ng K.T.P., Shao Y., LI C., Chung S.K., Ng I.O.L., Yu J. and Man K., Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling., Theranostics. 2017, 7: 4879-4893.

Wong H.S., Yeung P.K.K., Lai H.M., Lam K.S.L., Wu W. and Chung S.K., Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas: Three-Dimensional Histology of Pancreas by Tissue Clearing, In: Juan S. Bonifacino, Mary Dasso, Joe B. Harford, Jennifer Lippincott-Schwartz, Kenneth M. Yamada, Current Protocols in Cell Biology. Hoboken, NJ, USA, John Wiley & Sons, Inc., 2017, 77: 19.20.1-19.20.10.

Yang J., Machado M.D., Tsao G.S.W. and Chung S.K., A hybrid between classic and innovation: histology education in MBBS Curriculum of HKU LKS Faculty, The XXV International Symposium on Morphological Sciences. 2017.

Researcher : DENG J

List of Research Outputs

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

Researcher : DIRKZWAGER RM

List of Research Outputs

Figueroa M.G., Feng L., SHIU C.C., Dirkzwager R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhauser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017, University of Marburg, Germany. 2017.

Figueroa-Miranda G., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhausser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Sensors and Actuators B: Chemical. 2018, 255: 235-243.

LIANG S., Dirkzwager R.M. and Tanner J.A., 3D rapid prototyping aptamer-based malaria diagnostic device, 1st China Forum on Biosensors, Biochips and Nanobiotechnology (BBN China 2017), Foshan, Guangdong, China. 2017.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017.

Researcher : DONG C

List of Research Outputs

DONG C. and Huen M.S.Y., Functional Characterization of the DYRK1B-RNF169 Complex in DNA Double-Strand Breaks Responses, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

DONG C., Functional characterization of the DYRK1B-RNF169 complex in DNA double-strand breaks responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : DONG R

List of Research Outputs

DONG R., Lysosomal Ca²⁺ disruption induces autophagy impairment in familial Alzheimer's Disease (MPhil Thesis), The University of Hong Kong. 2017.

DONG R., The role of PRMT8 potential downstream targets G3BPs in synapse development and function, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : DU Y

List of Research Outputs

DU Y., Xie S., Huang H.A.O., Wang X.I.N. and Qian C., Characterization of a Novel Protein Complex in Ribosomal RNA Transcription, The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

DU Y., Structural insight of SPIN1-C84 protein complex, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Researcher : Deng J

List of Research Outputs

Researcher : Deng W

Project Title:	A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization
Investigator(s):	Deng W, Tsao GSW, Chen H
Department:	School of Nursing
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

List of Research Outputs

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Dirkzwager RM

List of Research Outputs

Researcher : Dung WF

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : FAN R

List of Research Outputs

FAN R., Elucidating the role of Kinesin 1 in mRNA transport in neuronal dendrites, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : FENG D

List of Research Outputs

YANG W., Garrett L., FENG D., Elliott G., Liu X., WANG N., Wong Y.M., Choi N.T.V., Yang Y. and Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : FENG R

List of Research Outputs

FENG R., Deleted in liver cancer2 (DLC2) regulates Wallerian degeneration and nerve regeneration after sciatic nerve transection in the MLDS-induced diabetes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

FENG R., Differential roles of endothelin type A and type B receptor in cofilin-actin rod formation and morphological change of hippocampal neurons (PhD Thesis), The University of Hong Kong. 2018.

Researcher : FOK HK

List of Research Outputs

FOK H.K., The Role of KIF5B mRNA Trafficking in Synaptic Plasticity, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : FRASER LA

List of Research Outputs

FRASER L.A., Kinghorn A.B., SHIU C.C., Serrano C.M., McClendon M.T., Stupp S.I. and Tanner J.A., Development of an instrument-free microfluidic biosensor for malaria diagnosis, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Kinghorn A.B., FRASER L.A., LIANG S., SHIU C.C. and Tanner J.A., Aptamer Bioinformatics, International Journal of Molecular Sciences. 2017.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

Tucker W.O., Cheung Y.W., FRASER L.A., Kinghorn A.B. and Tanner J.A., Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1, International journal of molecular sciences. 2018, 19(3): 763.

Researcher : FUNG CW

List of Research Outputs

FUNG C.W., Partnering role of FOXM1 and EPS8 in maintaining chemoresistance in human ovarian cancer cells (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : FUNG SW

List of Research Outputs

FUNG S.W., Characterization of ATP-binding cassette sub-family F member 1 (ABCF1) in liver cancer and fetal liver (PhD Thesis), The University of Hong Kong. 2018.

Researcher : FUNG SY

List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018.

Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

FUNG S.Y., Induction and activation of cGAS DNA sensor by Sindbis virus (PhD Thesis), The University of Hong Kong. 2017.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : Fan Y

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : Feng W

Project Title:	Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses
Investigator(s):	Feng W
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Researcher : Fu C

Project Title:	Systematic investigation of the roles of mitotic kinesins in spindle dynamics
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Molecular mechanisms of nuclear congression
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Researcher : Fung ML

Project Title:	Pathophysiological role of local inflammation in nitric oxide deficit in the carotid body in intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Pathophysiological roles of monoamine oxidase A in the oxidative stress and hippocampal neurodegeneration induced by chronic intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

POON C.H., Fung M.L. and Lim L.W., Normal global DNA methylation is necessary for memory enhancement by deep brain stimulation in an aged animal model, 16th Annual Meeting of Asian-Pacific Society for Neurochemistry, 2018.

YU Q., XIA Z., Liong E.C., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine and Chronic Aerobic Exercise Improve Insulin Sensitivity and Modulate Nrf2 and NF-κB/IκBα Pathways in the Skeletal Muscle of a Non-Alcoholic Fatty Liver Disease Animal Model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Zhang H., Yang F., Guo Y., Wang L., Fang F., Wu H., Nie S., Wang Y., Fung M.L., Huang Y., Deng H., Qin Y., Ma X. and Wei Y., The contribution of chronic intermittent hypoxia to OSAHS: from the perspective of serum extracellular microvesicle proteins, Metabolism. 2018, 85: 97-108.

Researcher : Fung SY

List of Research Outputs

FUNG S.Y., Induction and activation of cGAS DNA sensor by Sindbis virus (PhD Thesis), The University of Hong Kong. 2017.

Researcher : GHOSH S

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

GHOSH S., SIRT6 Activities in DNA Damage Repair and Premature Aging (PhD Thesis), The University of Hong Kong. 2017.

Researcher : GUO Y

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : Gao B

Project Title:	Identifying the genetic variants underlying carpal tunnel syndrome in a big family
Investigator(s):	Gao B, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Genetic Studies of Congenital Scoliosis
Investigator(s):	Gao B, Cheung JPY, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Regulation of non-canonical Wnt/PCP signaling by Vangl2 phosphorylation
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	07/2017

Project Title:	Gordon Research Conference: Wnt Signaling; Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2017
Completion Date:	08/2017

Project Title:	Understanding the molecular basis of Carpal Tunnel Syndrome
Investigator(s):	Gao B, Fok MWM, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	Elucidating the Role of ER stress/UPR in Carpal Tunnel Syndrome
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Gao B., Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity, Development. 2018, 145(8).

Gao B., Wnt Regulation of Planar Cell Polarity , The 3rd Youth Medical Forum of Chinese Society of Biochemistry and Molecular Biology. 2018.

Gao B., Wnt Regulation of Planar Cell Polarity in Development , Joint Annual Meeting of 70th JSCB and 51st JSDB. 2018.

Gao B., Wnt Regulation of Planar Cell Polarity in development and disease, Cheng Yu Tung Fellowships Symposium. 2017.

Gao B., Wnt-Induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, Gordon Research Conference - Wnt Signaling: A Pathway Implicated in Animal Development, Stem Cell Control and Cancer. 2017.

Gao B., Wnt-Induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, The 16th international symposium of Society of Chinese Bioscientists in America (SCBA). 2017.

Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, Cell Research. Nature, 2017.

YANG W., Garrett L., FENG D., Elliott G., Liu X., WANG N., Wong Y.M., Choi N.T.V., Yang Y. and Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Gao W

List of Research Outputs

Gao W., Tang H.M.V., Cheng Y., Chan C.P., Chan C.P. and Jin D., Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018, 1861: 211-223.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : HO CC

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

HO C.C., Studying the role of N-Myc in cochlear development using a gain-of-function approach (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : HO TH

List of Research Outputs

HO T.H., 42nd International Herpesvirus Workshop Travel Award 2017, International Herpesvirus Workshop. 2017.

HO T.H., Sitz J., Shen Q., Leblanc-Lacroix A., Campos E.I., Borozan I., Marcon E., Greenblatt J., Fradet-Turcotte A., Jin D. and Frappier L., A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein, Journal of Virology. 2018, 92.

HO T.H., Jin D. and Frappier L., Characterization of a novel Epstein-Barr virus tegument protein that inhibits the DNA damage response., 42nd International Herpesvirus Workshop, Ghent, Belgium, July 29 – August 2, 2017.. 2017.

Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : HUANG Y

List of Research Outputs

HUANG Y. and Lai S.W.C., Altered synaptic plasticity in a mouse schizophrenic model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Han L

List of Research Outputs

Chan Y.S., Han L., Li Y.H., Wu L.K. and Shum D.K.Y., Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors, Soc. Neuroscience Abstract (USA), 286.23 [Washington DC. Nov. 12-16, 2017]. 2017.

Han L. and Chan Y.S., Spontaneous transient outward currents in rat vestibular nucleus, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P47. 2018.

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

Peng Y.J., Zheng C.X., Chen X., Han L., Li M., Zhang G., Jiang H., Chan Y.S., Lau G.C. and He J., CCK released by entorhinal cortical neurons enables visuo-auditory associative learning, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Researcher : Han L

List of Research Outputs

Researcher : Hao Q

Project Title:	Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Novel Structure and Function of Human Sirtuins
Investigator(s):	Hao Q, Huang J, Li XD
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2015

Project Title:	Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug”
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	01/2019

Project Title:	Development of novel inhibitors targeting the resistance mechanisms of clinical superbugs
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

Hao Q., Structural Biology of Human Sirtuins, The 20th Shanghai Structural Biology Meeting, Shanghai, China. 2017.

Wang Y., Jin J., CHUNG W.H., Feng L., Sun H. and Hao Q., Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation, Proceedings of the National Academy of Sciences. 2018, 115: 2365-2370.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360.

Researcher : Hau WF

List of Research Outputs

Ho S.N., Wu L.K., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Identification of perineuronal net-associated plastic factors, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P39. 2018.

Researcher : Ho CC

List of Research Outputs

HO C.C., Studying the role of N-Myc in cochlear development using a gain-of-function approach (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : Ho SP

List of Research Outputs

Tipoe G.L., Ho S.P. and Wong P.W.L., Cadaveric Clinical Workshops for Postgraduate Residency Training for the Professional Specialties and Societies with the School of Biomedical Sciences (SBMS), The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2017, 77.

Researcher : Ho TH

List of Research Outputs

HO T.H., 42nd International Herpesvirus Workshop Travel Award 2017, International Herpesvirus Workshop. 2017.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit
Investigator(s):	Huang J, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2014

Project Title:	Pattern formation by bacteria: from theoretical physics to synthetic biology
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies
Investigator(s):	Huang J, Chen Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2015

Project Title:	Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration
Investigator(s):	Huang J, Sze KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Outstanding Researcher Award 2014-15
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	02/2016

Project Title:	Salmonella-induced host innate immunity against cancer metastasis
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	Virus-like particle (VLP)-based mucosal vaccine for inducing cross-serotype immunity against Streptococcus pneumoniae infection
Investigator(s):	Huang J, Ho PL, Yu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigation of the interaction between kinesin heavy chain and kinesin light chain
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	12/2018

Project Title:	Development of virus-like particle (VLP)-based vaccine against Streptococcus pneumoniae infection
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	Emerging Technologies in Vaccine Discovery and Development (J5); Combination of multiple antigens are essential for the development of a novel vaccine against Staphylococcus aureus infection
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	01/2018
Completion Date:	02/2018

Project Title:	Investigating the effect of Intracellular Sigma Protein in the treatment of amyotrophic lateral sclerosis and multiple sclerosis
Investigator(s):	Huang J, Wu W, Sun H
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	Mechanistic study of bacteria capable of inhibiting adjacent cell swarming
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Engineering bacterial outer membrane vesicles for targeted cancer immunotherapy
Investigator(s):	Huang J, Sun J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

List of Research Outputs

Durairajan S.S.K., Lyaswamy A.H., Shetty S.G., Malampati S.D., Shang W.B., Yang C.B., Song J.X., Chung S.K., Huang J., Ilango K., Han Q.B. and Li M., A modified formulation of Huanglian-Jie-Du Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease, Scientific Reports. 2017, 7: 6238.

Frédéric A., Alexandre K., Mathieu K., Nicolas G., Isabelle M., Bordet J.C., Huang J., Alain F.C., Delphine B.G., Geneviève S.B., Olivier C.T. and Gaël M.A., Kinesin-1 regulates platelet secretion and thrombus stability through the interaction with the granular Slp4/Rab27b effector complex, Arteriosclerosis, Thrombosis, and Vascular Biology. 2018, 38: 1037-1051.

Li J., Mao Z., Huang J. and Xia J., PICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis, Molecular Biology of the Cell. 2018, 29(5): 587-596.

Tokuyasu T.A. and Huang J., A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines, Journal of Cancer Metastasis and Treatment. 2018, 4: 2.

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253.

Researcher : Huen MSY

Project Title:	Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression
Investigator(s):	Huen MSY, Feng W
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014
Completion Date:	12/2017

Project Title:	Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Outstanding Young Researcher Award 2014-15
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	02/2016

Project Title:	Why does TRAIP/RNF206 Inactivation cause Microcephalic Primordial Dwarfism
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	03/2016
Completion Date:	02/2018

Project Title:	Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases
Investigator(s):	Huen MSY, Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2016

Project Title:	Role of HAUSP in DNA Damage Signal Transduction
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	12/2017

Project Title:	Role of The USP7-RNF169 Axis in DNA Double-Strand Break Responses
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Role of The BRCA1-A Complex in DNA Repair Control
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	A Study of TRAIP in Replicative Stress Responses: Regulation and Relevance to Seckel Syndrome
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2017

Project Title:	A Study of Self-Restraining Mechanisms of DNA Damage Surveillance and Repair
Investigator(s):	Huen MSY, Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2018

Project Title:	Deciphering Cancer Cell Resistance to Radiotherapy
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	A Study of DYRK1B in DNA Damage Surveillance and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

AN L. and Huen M.S.Y., chromatin profiling of DNA damage response proteins reveals a role of RNF169 in single strand annealing repair, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

CHE N., Tong M., Ng K.Y., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterization of PRMT6-Regulated Autophagy in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHEN Y. and Huen M.S.Y., A Mechanistic Study of TRAIP Mobilisation in Replication Stress Response, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

DONG C. and Huen M.S.Y., Functional Characterization of the DYRK1B-RNF169 Complex in DNA Double-Strand Breaks Responses, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Liu J., Lv L., Gong J., Tan Y., ZHU Y., Dai Y., Pan X., Huen M.S.Y., Li B., Tsao G.S.W., Huo J. and Cheung A., Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma, International Journal of Cancer. 2017.

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : Hui CC

List of Research Outputs

PAN W., HOR C., Hui C.C. and Sham M.H., Suppressor of fused (Sufu) and Spop orchestrate Gli2/3 functions to regulate mammalian hindbrain neural progenitor development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : IEONG IL

List of Research Outputs

IEONG I.L., Characterization of KAP1 Acetylation and its Roles in DNA Damage Repair (PhD Thesis), The University of Hong Kong. 2018.

Researcher : JIANG Q

List of Research Outputs

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Neonatal excitation-inhibition imbalance introduces long-lasting changes to neuronal recruitment in vestibular circuits for spatial navigation, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Rescuing developmental deficits in vestibular circuits by combined fluoxetine treatment and sensory training, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P13. 2018.

Chan Y.S., JIANG Q., Lai S.K., Wu L.K., Ma C.W. and Shum D.K.Y., Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation. Bulletin of Japan Soc Neurochemistry 56(2) : 119, [ 60^th Conference of Japan Society for Neurochemistry. Sendai, Japan. Sept. 7-9, 2017]. 2017.

Chan Y.S., JIANG Q., Shi W. and Shum D.K.Y., The engagement of GABA receptors in tuning navigational behavior., [ 38^th Congress of International Union of Physiological Sciences Rio de Janeiro, Brazil. Aug. 1-5, 2017]. 2017.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 61. 2017.

JIANG Q., Wu L.K., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of your adult rats by fluoxetine, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P12. 2018.

JIANG Q., Re-opening plasticity of vestibular circuitry for the correction of deficits in spatial navigation in the adult (PhD Thesis), The University of Hong Kong. 2018.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

Wan V.W., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Assessing the role of inhibitory interneurons in motor learning., Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P6. 2018.

Researcher : JIANG Y

List of Research Outputs

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. 2017.

JIANG Y., Role of Orexin in Regulating Synaptic Transmission and Spine Morphology in Central Vestibular System (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : JIANG Z

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

Researcher : JINATA C

List of Research Outputs

JINATA C., Kinghorn A.B., Cheung Y.W. and Tanner J.A., Design, optimization, and application of a target-free immobilization DNA aptamer selection approach against fluorophores, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

JINATA C., Kinghorn A.B. and Tanner J.A., Optimization of Graphene Oxide-Mediated DNA Aptamer Selections Against Fluorophores, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Jauch R

Project Title:	Programming functional cells for regenerative medicine with artificially evolved and enhanced transcription factors
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	05/2018

List of Research Outputs

Jauch R., DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1, Nucleic Acids Research. 2018.

Jauch R., Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing, Departmental Seminar of the Department of Cell and Developmental Biology of Karolinska Institutet, Stockholm. 2018.

Jauch R., Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing, Invited lecture at the Chinese University of Hong Kong. 2018.

Jauch R., Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing, Invited lecture at the Max Planck Institute for Molecular Genetics, Berlin, Germany. 2018.

Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.-.H., Wynn S., Mak A...C...Y..., Chan W...Y..., Jauch R., Fritzsch B., Lovell-Badge R., Sham M.H. and Cheah K.S.E., Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis, Molecular Biology of Hearing and Deafness 2018.

Researcher : Javed A

List of Research Outputs

Nichane M., Javed A., Sivakamasundari V., Ganesan M., Ang L.T., Kraus P., Lufkin T., Loh K.L. and Lim B., Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors, Nature Methods. 2017, 14: 1205-1212.

Researcher : Jia LJ

Project Title:	To investigate the role of AMP-activated protein kinase in the regulation of EBV latent and lytic infection in nasopharyngeal carcinoma
Investigator(s):	Jia LJ, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

List of Research Outputs

Jia L.J., Wu D., Wang Y., You W., Wang Z., Xiao L., Cai G., Xu Z., Zou C., Wang F., Teoh J.Y.C., Ng C.F., Yu S. and Chan F.L., Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription, Oncogene. 2018, 37: 3340-3355.

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Vérillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation, Laboratory Investigation. 2018, 98: 1093-1104.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Jia L.J., Tsang C.M. and Tsao G.S.W., EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma, Advances in Experimental Medicine and Biology. Springer, 2017, 1018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Outstanding Research Student Supervisor Award 2013-14
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2014

Project Title:	Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger
Investigator(s):	Jin D, Tse H
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein
Investigator(s):	Jin D, Yeung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response
Investigator(s):	Jin D, Yang W, Deng J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2016

Project Title:	Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases
Investigator(s):	Jin D, Deng J, Kong KY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Molecular Mechanism of PACT-dependent Innate Antiviral Response
Investigator(s):	Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Perturbation of MAVS-dependent antiviral response by PB1-F2 protein of influenza A (H7N9) virus and implications to viral pathogenesis
Investigator(s):	Jin D, Chen H, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Identification and characterization of MDM2 as an E3 ubiquitin ligase for STAT2 activated by Zika virus NS5 protein
Investigator(s):	Jin D, Yuen KS, Wang F
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Roles of BART non-coding RNAs in Epstein-Barr virus infection and oncogenesis (CRF)
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	Cell Symposium: Neuro-Immune Axis: Reciprocal Regulation in Development, Health, and Disease; Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	Regulatory roles of WD40 repeat-containing protein 5 (WDR5) in hepatitis B virus transcription
Investigator(s):	Jin D, Kong KY, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Yuen K.Y. and Jin D., Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells., Cell Symposium on “Neuro-Immune Axis: Reciprocal regulation in development, health, and disease, Sitges, Spain, September 17-19, 2017.. 2017.

CHEUNG P.H.H., Chan C.P. and Jin D., To announce or not to announce: What is known about the 2016–2017 influenza season in Hong Kong?, Emerging Microbes & Infections. 2017, 6: e78.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018.

Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Chan C.P., Kok K.H. and Jin D., Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia, 2017, 1018: 147-166.

Cheng Y., Wang F., Ye Z., Chan C.P., Chan C.P. and Jin D., Identification and characterization of a novel gene faci that alleviates highfat diet-induced metabolic syndrome in mice, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Gao W., Tang H.M.V., Cheng Y., Chan C.P., Chan C.P. and Jin D., Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018, 1861: 211-223.

HO T.H., Sitz J., Shen Q., Leblanc-Lacroix A., Campos E.I., Borozan I., Marcon E., Greenblatt J., Fradet-Turcotte A., Jin D. and Frappier L., A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein, Journal of Virology. 2018, 92.

HO T.H., Jin D. and Frappier L., Characterization of a novel Epstein-Barr virus tegument protein that inhibits the DNA damage response., 42nd International Herpesvirus Workshop, Ghent, Belgium, July 29 – August 2, 2017.. 2017.

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Jin D. and Berkhout B., CRISPR-Cas Antiviral Strategies, Virus Research. 2018, 244: 285.

Jin D., Curing hepatitis B virus infection for prevention of liver cancer, Trans-Guangdong-Hong Kong-Macau Bay Area Symposium on Translational Cancer Medicine, Shenzhen. 2017.

Jin D., Deputy Editor-In-Chief, 副主编, Chinese Journal of Biotechnology. 生物工程学报, 2017.

Jin D., Guest Editor, Special Issue of Viruses on “Applications of CRISPR Technology in Virology 2018”. 2018.

Jin D. and Berkhout B., Managing Guest Editor, Special Issue of Virus Research on “CRISPR-Cas Antiviral Strategies”. 2018, 244: 285-337.

Jin D., Member, 委员, China National Committee for Terms in Biochemistry and Molecular Biology 2018-2023. 第二届全国生物化学与分子生物学名词审定编写委员会, 2018.

Lau S.K.P., Zhang L.I.B.I.A.O., Luk K.H., Xiong L., Peng X.W., he X.I.A.N.G.Y.A.N.G., Zhao S., Fan R.Y.Y., Wong C.P., Ahmed S.S., Cai J., Chan J.F.W., Sun Y.I.N.Y.A.N., Jin D., Chen H., Lau T.C.K., Kok K.H., Li W.H., Yuen K.Y. and Woo P.C.Y., Receptor Usage Of A Novel Bat Lineage C Betacoronavirus Reveals Evolution Of Middle East Respiratory Syndrome-related Coronavirus Spike Proteins For Human Dipeptidyl Peptidase 4 Binding, The Journal Of Infectious Diseases. 2018, 218: 197-207.

Lee M.Y., Yip T.F., Yan S., Jin D., Wei H.L., Guo R.T. and Peiris J.S.M., Recognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10, Frontiers in Immunology. 2018, 9: 516.

Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855.

Researcher : Jin J

List of Research Outputs

Wang Y., Jin J., CHUNG W.H., Feng L., Sun H. and Hao Q., Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation, Proceedings of the National Academy of Sciences. 2018, 115: 2365-2370.

Researcher : Jones GE

List of Research Outputs

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : KHONG ML

List of Research Outputs

KHONG M.L., Li L., Solesio M.E., Lang C.Y.P., Pavlov E. and Tanner J.A., Polyphosphate Mediates Protein Folding in Human Osteoblasts, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

KHONG M.L., Li L., Solesio M.E.T., Lang C.Y.P., Evgeny P. and Tanner J.A., Polyphosphate: a mediator of protein folding in osteoblasts, 42nd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology. 2017.

Researcher : KWAN PY

List of Research Outputs

Chan Y.S., KWAN P.Y., Ma C.W. and Shum D.K.Y., Emerging role of perineuronal chondroitin sulfates and semaphorin 3A on the developing vestibular circuitry, Proc. 1^st International Conference on the Glycobiology of Nervous System p.40 [BK21PLUS Lecture. Seoul, Korea. Sept. 2-5, 2017]. 2017.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

KWAN P.Y., Regulatory Role of Perineuronal Chondroitin Sulfates and Semaphorin 3A in Developing Vestibular Circuitry (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Keung WWY

Project Title:	Modeling cardiomyopathy with 3D cardiac tissue constructs of patient specific induced-pluripotent stem cells
Investigator(s):	Keung WWY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016
Completion Date:	12/2017

List of Research Outputs

Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017.

Researcher : Kinghorn AB

Project Title:	Aptamers in Bordeaux 2017; Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif
Investigator(s):	Kinghorn AB
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017

List of Research Outputs

Cheung Y.W., Tanner J.A. and Kinghorn A.B., In: Julian A. Tanner, Andrew B. Kinghorn, Yee-Wai Cheung, International Journal of Molecular Sciences, Special Issue: Aptamer. 2017.

FRASER L.A., Kinghorn A.B., SHIU C.C., Serrano C.M., McClendon M.T., Stupp S.I. and Tanner J.A., Development of an instrument-free microfluidic biosensor for malaria diagnosis, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

JINATA C., Kinghorn A.B., Cheung Y.W. and Tanner J.A., Design, optimization, and application of a target-free immobilization DNA aptamer selection approach against fluorophores, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

JINATA C., Kinghorn A.B. and Tanner J.A., Optimization of Graphene Oxide-Mediated DNA Aptamer Selections Against Fluorophores, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Kinghorn A.B., Tang Y.H., Shum H.C. and Tanner J.A., An efficient droplet-based nucleic acid amplification method for directed evolution of functional nucleic acids, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Kinghorn A.B., FRASER L.A., LIANG S., SHIU C.C. and Tanner J.A., Aptamer Bioinformatics, International Journal of Molecular Sciences. 2017.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

Kinghorn A.B. and Tanner J.A., Selective Phenome Growth Adapted NK Model: A Novel Landscape to Represent Aptamer Ligand Binding , Complexity. 2017, 2017: 6760852, 1-12.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Automated electrochemical sensing system for monitoring luteinizing hormone pulsatility, Aptamers 2018, 5th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2018.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Continuous flow electrochemical sensing systems for monitoring luteinizing hormone pulsatility by oligonucleotide aptamer structure switching, Oligo 2018: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2018.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

Tucker W.O., Cheung Y.W., FRASER L.A., Kinghorn A.B. and Tanner J.A., Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1, International journal of molecular sciences. 2018, 19(3): 763.

Researcher : Kong KY

Project Title:	Roles of the chromatin architectural protein CTCF in hepatitis B virus transcription
Investigator(s):	Kong KY, Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2017

Project Title:	Protein Homeostasis in Health and Disease; Optimal heat shock induced expression of the Sis1 chaperone requires the Hsf1-independent degradation of the RNA quality control factor Dis3 which normally suppresses protein quality control activity by specifically degrading the Sis1 mRNA
Investigator(s):	Kong KY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

Researcher : Kudelko MA

List of Research Outputs

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Kwok LF

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 63. 2017.

Kwok L.F., Soo Z.K., Tam K.W., Shum D.K.Y. and Chan Y.S., Use of chondroitinase ABC-chitosan microbeads for treatment of spinal cord injury in rat, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P17. 2018.

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Yip H.M., Kwok L.F., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cell-seeded chitosan nanofibers for nerve regeneration, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P14. 2018.

Researcher : LAM CF

List of Research Outputs

LAM C.F., Yeung H.T., Lam Y.M. and Ng R.K., Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway, Leukemia Research. 2018, 68: 112-119.

Researcher : LAM TF

List of Research Outputs

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. 2017.

Researcher : LAU CC

List of Research Outputs

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

Researcher : LEUNG OW

List of Research Outputs

LEUNG O.W. and Chan D., Implications of Gas1 in Synovial Joint Cavitation and Disease Mechanism of Brachydactyly A1, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : LI C

List of Research Outputs

LI C., The Role of Autophagy in Enterovirus-71 Infection and the Therapeutic Effect of Autophagy Inhibition by Saikosaponin D (PhD Thesis), The University of Hong Kong. 2017.

Researcher : LI H

List of Research Outputs

Li J., Chen S., Zhao Z., Luo Y., Hou Y., LI H., He L., Zhou L. and Wu W., Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection, Frontiers in Cellular Neuroscience. 2017, 11.

Researcher : LI T

List of Research Outputs

LI T., Molecular dissection of mitochondria-microtubule interaction and microtubule nucleation (PhD Thesis), The University of Hong Kong. 2017.

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Researcher : LI T

List of Research Outputs

LI T., Molecular dissection of mitochondria-microtubule interaction and microtubule nucleation (PhD Thesis), The University of Hong Kong. 2017.

Researcher : LI TW

List of Research Outputs

LI T.W., Zhou L., Lee T. and Ma S.K.Y., Myofibroblast secreted follistatin-like 1 (FSTL1) promotes metastasis and stemness of hepatocellular carcinoma (HCC), 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LI T.W., Myofibroblast-secreted follistatin-like 1 (FSTL1) promotes Hepatocellular Carcinoma formation and metastasis, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : LI X

List of Research Outputs

LI X., Mak C.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LI X., Mak C.Y., Zhou Y., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., PIK3R1 loss activates AKT and STAT3 signaling in ovarian cancer, American Association of Cancer Research Annual Meeting 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., PIK3R1 loss predicts sensitivity to AKT and STAT3 inhibitors in ovarian cancer, 2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., Targeting PIK3R1 loss by AKT and STAT3 inhibitors in ovarian cancer, 13th International Symposium on Healthy Aging. 2018.

Researcher : LI Z

List of Research Outputs

LI Z., Investigation of the role of Sox10 in enteric neural crest cell adhesion using the Sox-10 NGFP mouse model (PhD Thesis), The University of Hong Kong. 2018.

LI Z., Neuronal Heparanase 1 and its Involvement in Homeostatic Plasticity (PhD Thesis), The University of Hong Kong. 2017.

Researcher : LI Z

List of Research Outputs

LI Z., Investigation of the role of Sox10 in enteric neural crest cell adhesion using the Sox-10 NGFP mouse model (PhD Thesis), The University of Hong Kong. 2018.

LI Z., Neuronal Heparanase 1 and its Involvement in Homeostatic Plasticity (PhD Thesis), The University of Hong Kong. 2017.

Researcher : LIANG S

List of Research Outputs

Kinghorn A.B., FRASER L.A., LIANG S., SHIU C.C. and Tanner J.A., Aptamer Bioinformatics, International Journal of Molecular Sciences. 2017.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

LIANG S., Dirkzwager R.M. and Tanner J.A., 3D rapid prototyping aptamer-based malaria diagnostic device, 1st China Forum on Biosensors, Biochips and Nanobiotechnology (BBN China 2017), Foshan, Guangdong, China. 2017.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Automated electrochemical sensing system for monitoring luteinizing hormone pulsatility, Aptamers 2018, 5th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2018.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Continuous flow electrochemical sensing systems for monitoring luteinizing hormone pulsatility by oligonucleotide aptamer structure switching, Oligo 2018: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2018.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

Researcher : LIN L

List of Research Outputs

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LIN L., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

LO H.Y.L., LIN L., LYU Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, The 40th Annual Meeting of the Japan Neuroscience Society. 2017.

Researcher : LIU M

List of Research Outputs

LIU M., Yu Y.Y., Choi N.T.V., Cheung Y.W. and Tanner J.A., Inhibitory effects of apt21 and apt25 on the enzymatic activity of ADAMTS-5, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : LIU T

List of Research Outputs

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : LIU Y

List of Research Outputs

LIU Y., Study of inner ear sensory epithelia development using Irx3 and Irx5 mutant mouse models (PhD Thesis), The University of Hong Kong. 2018.

Researcher : LO HYL

List of Research Outputs

LO H.Y.L., LIN L., LYU Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, The 40th Annual Meeting of the Japan Neuroscience Society. 2017.

LO H.Y.L., Protein arginine methyltransferase 8 (PRMT8) is a novel regulatory protein in synapse development of neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : LOONG HC

List of Research Outputs

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : LUK TCS

List of Research Outputs

LUK T.C.S., Tong M., Ng K.Y., Yip K.Y.L., Guan X. and Ma S.K.Y., Role of REX1 Down-Regulation in Promoting Cancer Stemness Properties in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LUK T.C.S., Role of REX1 downregulation in promoting cancer and stemness properties in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences in 2018.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Researcher : LYU Q

List of Research Outputs

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LO H.Y.L., LIN L., LYU Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, The 40th Annual Meeting of the Japan Neuroscience Society. 2017.

LYU Q., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : Lai KO

Project Title:	Investigating the functional role of a novel synaptic protein TBC1D24 in activity-dependent spine morphogenesis
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Investigating the regulatory role of protein arginine methylation in dendritic spine development
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2016

Project Title:	Investigating the function of protein arginine methyltransferase PRMT5 in neuron: regulatory role in mRNA tranpsort and dendritic spine maturation
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Investigating the role of the kinesin motor KIF5B in dendritic mRNA trafficking in neurons
Investigator(s):	Lai KO, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Investigation of protein localization and transport dynamics in human neuron by genome editing
Investigator(s):	Lai KO, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

Project Title:	The 40th Annual Meeting of the Japan Neuroscience Society; Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2017
Completion Date:	07/2017

Project Title:	Understanding the role of the protein arginine methyltrasnferase PRMT8 in determining the morphology of dendritic spines and localization of excitatory synapses in hippocampal neuron
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

List of Research Outputs

Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y., Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development., Proc Natl Acad Sci U S A.. 2017, 114: E6992-E7001.

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LO H.Y.L., LIN L., LYU Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, The 40th Annual Meeting of the Japan Neuroscience Society. 2017.

Lai K.O., Associate Editor, Neural Circuits. 2017.

Lai K.O., Synapse development of neuron: focus on dendritic mRNAs, 210th iCEMS Seminar (Kyoto University). 2017.

Lai K.O., Understanding synapses through imaging, Croucher Symposium in Advanced Imaging. 2017.

Lyn Q., Fan R., Zhao J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization induced iPSC-derived cortical neurons through genome editing, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Researcher : Lai SWC

Project Title:	Mechanism of fear associative learning in the frontal association cortex and its implications in schizophrenia
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2015

Project Title:	The role of sleep on fear learning and dendritic spine plasticity
Investigator(s):	Lai SWC, Cheung WH
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Cue-specific dendritic spine plasticity of fear conditioning and extinction in the mouse auditory cortex
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Mechanisms underlying the antidepressant effects of ketamine in an animal model of depression: the role of dendritic spines and interneurons
Investigator(s):	Lai SWC, Chang RCC, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016
Completion Date:	04/2019

Project Title:	Reversible microcircuitry of fear learning and unlearning in the mouse auditory cortex
Investigator(s):	Lai SWC, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Advanced optogenetics and functional calcium imaging platform for deep brain structures in awake, free-moving, and behaving animals in learning and memory
Investigator(s):	Lai SWC, Chan YS, Chang RCC, Chan SY, Cheung MCH, Lai KO, Lo ACY, Lee CW, Lim LW, Shum DKY, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	The role of KIF5B in learning and memory
Investigator(s):	Lai SWC, Huang J, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Effects of environmental enrichment on synaptic plasticity in NMDAR hypofunction
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

HUANG Y. and Lai S.W.C., Altered synaptic plasticity in a mouse schizophrenic model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

KONG C., Pilger C., Hachmeister H., Wei X., Cheung T.H., Lai S.W.C., Huser T., Tsia K.K.M. and Wong K.K.Y., Compact fs ytterbium fiber laser at 1010 nm for biomedical applications, Biomedical Optics Express. 2017, 8: 4921.

Lai S.W.C., Live animal imaging technique in neuroscience, IBRO Advanced School of Neuroscience 2017. 2017.

Researcher : Lai WL

List of Research Outputs

Chan W.L., Lai W.L., SO P.Y. and Ching Y.P., Oncogenic role of CD133 in Hepatocellular Carcinoma, In: merican Association for Cancer Research (AACR), American Association for Cancer Research (AACR), Annual Meeting, Apr. 2018, Chicago, USA. 2018.

YEUNG S.F., Lai W.L. and Ching Y.P., The role of centrosome amplification in HCC, In: AACR, American Association for Cancer Research (AACR), Annual Meeting, April, 2018, Chicago, USA. 2018.

Researcher : Lam YM

List of Research Outputs

LAM C.F., Yeung H.T., Lam Y.M. and Ng R.K., Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway, Leukemia Research. 2018, 68: 112-119.

MAK H.M., Lam Y.M. and Ng R.K., Kdm4 histone demethylase family is required to maintain trophoblast stem cell fate by modulation of H3K9me3 status, International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23,2018, Melbourne, Australia. 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Aberrant DNA methylation alters transcriptional program in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia, 59th ASH Annual Meeting and Exposition, December 9-12, 2017, Atlanta, USA. 2017.

Researcher : Lan Y

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : Lau CYW

Project Title:	Structural role of the BRCA1-PALB2-BRCA2 complex in DNA repair
Investigator(s):	Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	AXA Research Fund
Start Date:	08/2014

Researcher : Lau YTC

List of Research Outputs

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Researcher : Lee CW

Project Title:	Live imaging of acetylcholine receptor trafficking at developing neuromuscular junctions
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	01/2016
Completion Date:	01/2018

Project Title:	Spatiotemporal regulation of actin monomers for promoting membrane protrusions in axonal growth, guidance and regeneration
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Investigating the pathogenic mechanisms underlying ocular and generalized myasthenia gravis using Xenopus cell-based assay
Investigator(s):	Lee CW, Chan KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigating the effects of ALS-linked mutations in Profilin on neuronal actin dynamics using an in vitro ALS model
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Site-directed trafficking and clustering of acetylcholine receptors in the formation of neuromuscular synapses
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Signaling by Adhesion Receptors; Site-directed MT1-MMP surface insertion regulates neuromuscular synaptogenesis via focal ECM degradation
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

CHAN C.K., Wong Y.S. and Lee C.W., Extracellular matrix protein-induced assembly of podosome-like structures for aneural acetylcholine receptor cluster remodeling, 37th Annual Scientific Meeting of the Australasian Neuroscience Society. 2017.

Tse C.L., Herlea-Pana O., Brobst D., Yang X., Wood J., Hu X., Liu Z., Lee C.W., Zaw A.M., Chow B.K.C., Ye K. and Chan C.B., Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle, Diabetes. 2017, 66: 1858-1870.

Researcher : Leung KKH

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

Researcher : Li B

List of Research Outputs

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

Liu J., Lv L., Gong J., Tan Y., ZHU Y., Dai Y., Pan X., Huen M.S.Y., Li B., Tsao G.S.W., Huo J. and Cheung A., Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma, International Journal of Cancer. 2017.

Researcher : Li L

List of Research Outputs

KHONG M.L., Li L., Solesio M.E., Lang C.Y.P., Pavlov E. and Tanner J.A., Polyphosphate Mediates Protein Folding in Human Osteoblasts, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

KHONG M.L., Li L., Solesio M.E.T., Lang C.Y.P., Evgeny P. and Tanner J.A., Polyphosphate: a mediator of protein folding in osteoblasts, 42nd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology. 2017.

Researcher : Li RA

Project Title:	Cell-based Heart Regeneration
Investigator(s):	Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2011
Completion Date:	09/2017

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Establishing a Molecular Encyclopedia for Stem Cell & Regenerative Medicine: Heart
Investigator(s):	Li RA, Tam PKH, Cheung YF
Department:	Dr. Li Dak-Sum Research Centre
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 2)
Start Date:	08/2016

Researcher : Li SK

Project Title:	A Study of the Roles of Hepatitis B Virus X Protein on the Transcriptional Regulation of Tumor Suppressor TAX1BP2 in Hepatocellular Carcinoma
Investigator(s):	Li SK, Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

Researcher : Lian F

List of Research Outputs

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Researcher : Lim LW

Project Title:	Comparative study of potential brain target stimulation for cognitive improvement in aged animal model
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	04/2016
Completion Date:	04/2018

Project Title:	Memory and cognitive enhancement by electrical stimulation in experimental animal models of dementia: In search of brain targets and mechanisms
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2016

Project Title:	Hippocampal gene expression profiling after deep brain stimulation in aged animal model of cognitive impairment
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2017

Project Title:	Microarray profiling and molecular characterization of the hippocampus after chronic electrical stimulation in an aged animal model of cognitive impairment
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2017
Completion Date:	11/2017

Project Title:	25th International "Stress and Behavior" Neuroscience and Biopsychiatry Conference; Deep brain stimulation in experimental stress animal model of depression
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

List of Research Outputs

Chan R.W., LEONG T.L., Ho C.C., Gao P., WONG C.S., DONG M., WANG X., He J., Chan Y.S., Lim L.W. and Wu E.X., Low frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity. , Proceedings of the National Academy of Sciences. 2017.

Chan R.W., Leong A.T., Wong E.C., Ho L.C., Gao P.P., Dong C.M., Chan Y.S., Lim L.W. and Wu E.X., Low frequency hippocampal-cortical activity drives brain-wide resting-state functional connectivity: An optogenetic functional MRI study., Soc. Neuroscience Abstract (USA). 2017, 717: 04.

Heng B.C.A., GONG T., XU J., Lim L.W. and Zhang C., EphrinB2 signalling modulates the neural differentiation of human dental pulp stem cells, Biomedical Reports. 2018.

Lim L.W., Deep brain stimulation from antidepressant to memory enhancement., Research Seminar, Guangzhou University of Chinese Medicine, Guangzhou, China.. 2018.

Lim L.W., Deep brain stimulation in experimental stress animal model of depression (ISBS Invited Special Plenary Speaker), 5th Multidisciplinary International Neuroscience and Biological Psychiatry Conference. The International Stress and Behavior Society (ISBS). St. Petersburg, Russia.. 2018.

Lim L.W., Deep brain stimulation in experimental stress animal model of depression., 25th Multidisciplinary International Neuroscience and Biological Psychiatry Conference. The International Stress and Behavior Society (ISBS).. 2018.

Mohd Kushairi N., Sabaratnam V., Lim L.W. and Wong K.H., 1st Place Oral Presentation Award, Malaysian Anatomical Association Symposium. 2017.

POON C.H., Fung M.L. and Lim L.W., Normal global DNA methylation is necessary for memory enhancement by deep brain stimulation in an aged animal model, 16th Annual Meeting of Asian-Pacific Society for Neurochemistry, 2018.

Researcher : Lin B

Project Title:	annual meeting of the association for research in vision and ophthalmology ; PTEN deletion enhances the survival of cone photoreceptors in retinal degeneration disorders
Investigator(s):	Lin B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016

Researcher : Lin Q

List of Research Outputs

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253.

Researcher : Lin W

List of Research Outputs

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Vérillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation, Laboratory Investigation. 2018, 98: 1093-1104.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : Liong EC

List of Research Outputs

YU Q., XIA Z., Liong E.C., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine and Chronic Aerobic Exercise Improve Insulin Sensitivity and Modulate Nrf2 and NF-κB/IκBα Pathways in the Skeletal Muscle of a Non-Alcoholic Fatty Liver Disease Animal Model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Liu AJ

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Hui M.N., Wu M.H. and Cheung M.C.H., Elucidating the roles of SOX9 in human neural stem cells., Keystone Symposium: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (T3). 2017.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

RAO Y., Cheung M.P.L., Liu A.J., Sharma R. and Cheung M.C.H., A dual role for DLC1 in regulating avian cranial neural crest cell fate commitment and delamination, The Hong Kong Inter-University Postgraduate Symposium in Biomedical Sciences. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2013

Researcher : Liu P

List of Research Outputs

De Bruyckere E., Simon R., Nestel S., Heimrich B., Kätzel, D., Egorov A.V., Liu P., Jenkins N.A., Copeland N.G., Schwegler H. and Draguhn A., Britsch S., Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2, Frontiers in Molecular Neuroscience. 2018, 11.

Fang D., Cui K., Hu G., Gurram R.K., Zhong C., Oler A.J., Yagi R., Zhao M., Sharma S., Liu P., Sun B., Zhao K. and Zhu J., Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation, The Journal of Experimental Medicine. 2018, 215: 1449-1462.

Researcher : Lu J

Project Title:	ENS 5th International Symposium, Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy; Identification of a novel enteric neural crest derived population in the developing mouse gut
Investigator(s):	Lu J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification Of Subpopulations And Molecular Signatures Of Enteric Neural Crest Via Single Cell Transcriptomics, Keystonesymposia T3: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering, Hong Kong, 15-19 Oct 2017.

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification of a novel enteric neural crest derived population in the developing mouse gut (Poster Presentation), The 5th International Symposium on Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy, Boston, U.S.A., 8-11 April 2018.

Researcher : Lui PY

List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H. and Jin D., Double-stranded RNA binding protein PACT mediates its antiviral activity against influenza A virus via suppression of viral RNA polymerase, EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL Heidelberg, Germany, June 24-27, 2018.. 2018.

Chan C.P., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Kok K.H. and Jin D., Dual anti-influenza virus activity of PACT through activation of RIG-I and suppression of viral RNA polymerase, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855.

Researcher : Lui WC

List of Research Outputs

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Aberrant DNA methylation alters transcriptional program in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia, 59th ASH Annual Meeting and Exposition, December 9-12, 2017, Atlanta, USA. 2017.

Researcher : Lui Kau WF

List of Research Outputs

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Researcher : MAK HM

List of Research Outputs

MAK H.M., Lam Y.M. and Ng R.K., Kdm4 histone demethylase family is required to maintain trophoblast stem cell fate by modulation of H3K9me3 status, International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23,2018, Melbourne, Australia. 2018.

Researcher : Ma CW

List of Research Outputs

Chan Y.S., JIANG Q., Lai S.K., Wu L.K., Ma C.W. and Shum D.K.Y., Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation. Bulletin of Japan Soc Neurochemistry 56(2) : 119, [ 60^th Conference of Japan Society for Neurochemistry. Sendai, Japan. Sept. 7-9, 2017]. 2017.

Chan Y.S., KWAN P.Y., Ma C.W. and Shum D.K.Y., Emerging role of perineuronal chondroitin sulfates and semaphorin 3A on the developing vestibular circuitry, Proc. 1^st International Conference on the Glycobiology of Nervous System p.40 [BK21PLUS Lecture. Seoul, Korea. Sept. 2-5, 2017]. 2017.

Chan Y.S., Shi W., Wu L.K., Ma C.W. and Shum D.K.Y., Endocannabinoid-mediated modulation of sensorimotor circuits for the navigational system, [12^th Biennial Conference of Chinese Neuroscience Society. Tianjin Oct. 12-15, 2017]. 2017.

Ho S.N., Wu L.K., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Identification of perineuronal net-associated plastic factors, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P39. 2018.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 61. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. 2017.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

Ma C.W., Chu J.Y.S., Chan Y.S. and Shiu S.Y.W., Integrated life science education in Bachelor of Nursing and Bachelor of Chinese Medicine at The University of Hong Kong, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education, PP54. 2017.

Ma C.W., Chan L.K., Lam I.H.Y. and Chan Y.S., Use of augmented reality to optimize the effectiveness of biomedical education, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education , PP55. 2017.

Researcher : Ma SKY

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):	Ma SKY, Guan X, Lo CM, Man K
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	09/2017

Project Title:	Role of PRMT6 in regulating cancer and stemness properties in hepatocellular carcinoma
Investigator(s):	Ma SKY, Leung SY, Yan HHN
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Role of MAPK11 in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	09/2018

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications (CRF)
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	Role of protein arginine methyltransferase 6 (PRMT6) in metabolic reprogramming in hepatocellular carcinoma
Investigator(s):	Ma SKY, Wong CCL
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	PRMT6 binds to and methylates BAG5, BAG6, AMBRA1 and SQSTM1 to regulate autophagy in liver cancer
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	American Association for Cancer Research Annual Meeting 2018; Antibody-mediated blockade of annexin A3 (ANXA3) synergistically enhances the efficacy of sorafenib and regorafenib for hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

Project Title:	Establishment, characterization and applications of normal liver and hepatocellular carcinoma organoid cultures
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	05/2018

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

CHE N., Tong M., Ng K.Y., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterization of PRMT6-Regulated Autophagy in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHENG Y.L.B., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Lin C.H., Lo C.L.R., Ma S.K.Y., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Research. 2018, 78(9): 2332-2242.

Chan L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Ching Y.P., Yuan Y.F., Xie D., Richard S., Huan M.S. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates cancer stemness through CRAF methylation in hepatocellular carcinoma, AACR-Annual Meeting 2018, Chicago, IL, USA. 2018.

Che N., Tong M., Ng K.Y., Huan M.S. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6- regulated autophagy in hepatocellular carcinoma, AACR-Annual Meeting 2018, Chicago, IL, USA. 2018.

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

LI T.W., Zhou L., Lee T. and Ma S.K.Y., Myofibroblast secreted follistatin-like 1 (FSTL1) promotes metastasis and stemness of hepatocellular carcinoma (HCC), 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LUK T.C.S., Tong M., Ng K.Y., Yip K.Y.L., Guan X. and Ma S.K.Y., Role of REX1 Down-Regulation in Promoting Cancer Stemness Properties in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Luk S.T., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis, AACR-Annual Meeting 2018, Chicago, IL, USA. 2018.

Luk S.T.C., Tong M., Ng K.Y., Yip K.Y.L., Guan X. and Ma S.K.Y., Abstract 4352: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis , AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. 2017, 77: 4352-4352.

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Ma S.K.Y., Cytoplasmic PRMT6 regulates liver cancer stemness and glucose metabolism rewiring via CRAF arginine methylation, Croucher Summer Course in Cancer Biology 2017. 2017.

Ma S.K.Y., Cytoplasmic PRMT6 regulates liver cancer stemness and glucose metabolism rewiring via CRAF arginine methylation, State Key Laboratory of Digestive Disease, Chinese University of Hong Kong. 2017.

Ma S.K.Y., Exploiting stemness as a cancer cell vulnerability using hepatocellular carcinoma as a model system, International Society for Stem Cell Research (ISSCR) Annual Meeting, Melbourne, Australia. 2018.

Ma S.K.Y., Protein arginine methyltransferase 6 (PRMT6) regulates liver cancer stemness and glucose metabolic rewiring via CRAF/ERK signaling, Symposium 2017 of State Key Laboratory for Liver Research. 2017.

Ma S.K.Y., Protein methyltransferase PRMT6 regulates cancer stemness through CRAF arginine methylation in hepatocellular carcinoma, Cold Spring Harbor Asia Conferences – Liver Metabolism, Diseases and Cancer, Suzhou, China. 2017.

Ma S.K.Y., Ton Duc Thang University Scientific Prize - Rising Star Award (Vietnam), Ton Duc Thang University. 2018.

Ma S.K.Y., University of British Columbia Alumni Builder Award (Canada), University of British Columbia. 2017.

Ng K.Y., Chan L.H., Chai S., Tong M., Guan X., Lee N.P., Yuan Y.F., Xie D., Lee T.K., Carrier A., Dusetti N.J. and Ma S.K.Y., Abstract 4842: TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma, AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. 2017, 77: 4842-4842.

Ng K.Y., Chan J.L.H., Chai S., Tong M., Guan X., Lee N.P.Y., Yuan Y.F., Xie D., Lee T.K., Dusetti N.J., Carrier A. and Ma S.K.Y., TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma, Cancer Research. 2017, 77(17): 4602-4612.

Tong M., Wong T.L., Luk S.T.C., Che N., Wong K.Y., Fung T.M., Guan X., Lee N.P., Yuan Y.F., Lee T.K. and Ma S.K.Y., Abstract 1548: Down-regulation of 4-hydroxyphenylpyruvate dioxygenate (HPD) contributes to the pathogenesis of hepatocellular carcinoma (HCC) through ERK / BCL-2 signalling activation, AACR Annul Meeting 2017; April 1-5, 2017, Washington DC, USA. 2017, 77: 1548-1548.

Tong M., Wong T.L., Luk S.T., Che N., Wong K.Y., Fung T.M., Lee N.P., Yuan Y.F., Lee T.K. and Ma S.K.Y., Deranged tyrosine metabolism drives tumorigenesis in liver cancer, AACR-Annual Meeting 2018, Chicago, IL, USA. 2018.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Wong T.L., CHAN L.H. and Ma S.K.Y., Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2, AACR Annual Meeting 2017. 77(13 Suppl): Abstract nr 5416.

Zhou J., Siu H.C., Tong M., Chai S., Loong H.C., Sin S., Clevers H., Lo C.M., Man K., Guan X., Wongg D., Yan H.H., Leung S.Y. and Ma S.K.Y., Establishment of human primary hepatocellular carcinoma-derived organoid cultures for disease modeling and drug screening, International Society for Stem Cell Research- Annual Meeting, Melbourne, Australia. 2018.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Ma SKY

List of Research Outputs

Ma S.K.Y., Cytoplasmic PRMT6 regulates liver cancer stemness and glucose metabolism rewiring via CRAF arginine methylation, Croucher Summer Course in Cancer Biology 2017. 2017.

Ma S.K.Y., Ton Duc Thang University Scientific Prize - Rising Star Award (Vietnam), Ton Duc Thang University. 2018.

Ma S.K.Y., University of British Columbia Alumni Builder Award (Canada), University of British Columbia. 2017.

Wong T.L., CHAN L.H. and Ma S.K.Y., Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2, AACR Annual Meeting 2017. 77(13 Suppl): Abstract nr 5416.

Researcher : Machado MD

List of Research Outputs

Yang J., Machado M.D., Tsao G.S.W. and Chung S.K., A hybrid between classic and innovation: histology education in MBBS Curriculum of HKU LKS Faculty, The XXV International Symposium on Morphological Sciences. 2017.

Researcher : Mak CY

List of Research Outputs

LI X., Mak C.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LI X., Mak C.Y., Zhou Y., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., PIK3R1 loss activates AKT and STAT3 signaling in ovarian cancer, American Association of Cancer Research Annual Meeting 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., PIK3R1 loss predicts sensitivity to AKT and STAT3 inhibitors in ovarian cancer, 2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., Targeting PIK3R1 loss by AKT and STAT3 inhibitors in ovarian cancer, 13th International Symposium on Healthy Aging. 2018.

Researcher : Miao X

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : NG HLL

List of Research Outputs

NG H.L.L., Protective effect on dendritic spines against stress by ketamine involves parvalbumin interneurons, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : NGAN HL

List of Research Outputs

NGAN H.L., Mitogen-activated protein kinase (MAPK) pathway aberrations in head and neck squamous cell carcinoma (MPhil thesis), The University of Hong Kong. 2017.

Researcher : Ng HWH

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : Ng KY

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

CHE N., Tong M., Ng K.Y., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterization of PRMT6-Regulated Autophagy in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

LUK T.C.S., Tong M., Ng K.Y., Yip K.Y.L., Guan X. and Ma S.K.Y., Role of REX1 Down-Regulation in Promoting Cancer Stemness Properties in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Ng RK

Project Title:	The role of BMI-1 in regulation of JAK-STAT signaling pathway in human leukemia
Investigator(s):	Ng RK, Yiu SM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Epigenetic regulation of enhancer RNA in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2018

Project Title:	Epigenetic function of TET2 in the transcriptional regulation of MLL-rearranged leukemia
Investigator(s):	Ng RK, Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016
Completion Date:	04/2019

Project Title:	Regulation of JNK signaling pathway by reactive oxygen species in the differentiation of acute myeloid leukemia cells
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia
Investigator(s):	Ng RK, Leung AYH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2017

Project Title:	Functional role of Amer2 in the regulation of canonical Wnt signaling in hematopoietic stem cells
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

LAM C.F., Yeung H.T., Lam Y.M. and Ng R.K., Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway, Leukemia Research. 2018, 68: 112-119.

MAK H.M., Lam Y.M. and Ng R.K., Kdm4 histone demethylase family is required to maintain trophoblast stem cell fate by modulation of H3K9me3 status, International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23,2018, Melbourne, Australia. 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Aberrant DNA methylation alters transcriptional program in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia, 59th ASH Annual Meeting and Exposition, December 9-12, 2017, Atlanta, USA. 2017.

Researcher : Ng VCW

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Researcher : Ni Y

Project Title:	Three-Dimensional Super-Resolution Visualization of specific non-repetitive DNA in Single Mammalian Cells
Investigator(s):	Ni Y, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

Liu J., Rao Y., Cheung M., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheak K., Sharma R., Hodgson L. and Cheung M., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, Nat Commun . 2017.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

Researcher : PAN W

List of Research Outputs

PAN W., HOR C., Hui C.C. and Sham M.H., Suppressor of fused (Sufu) and Spop orchestrate Gli2/3 functions to regulate mammalian hindbrain neural progenitor development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : PANG CCC

List of Research Outputs

PANG C.C.C., Kiecker C., O’Brien J.T., Noble W. and Chang R.C.C., Ammon’s Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration, The Neuroscientist. 2018, 107385841877874.

Researcher : POON CH

List of Research Outputs

POON C.H., Fung M.L. and Lim L.W., Normal global DNA methylation is necessary for memory enhancement by deep brain stimulation in an aged animal model, 16th Annual Meeting of Asian-Pacific Society for Neurochemistry, 2018.

Researcher : Poon NYE

Project Title:	The effect of miR-200c on the electrophysiological maturation of human embryonic stem cell derived cardiomyocytes
Investigator(s):	Poon NYE, Boheler KR, Li RA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

Project Title:	Identification of the optimal source of human mesenchymal stromal cells for the treatment of acute graft-versus-host disease under a clinical-grade ex-vivo culture system
Investigator(s):	Poon NYE, Chan GCF, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

List of Research Outputs

Chen Y., Huang L., Dai X., Tian Q., Yu M., Agheb M., Chan N.C., Poon N.Y.E., Guo Z., Boheler K.R. and Wu H., Facile formation of a microporous chitosan hydrogel based on self-crosslinking Journal of Materials Chemistry, Journal of Materials Chemistry. 2017, 2017; 5: 9291-9299.

Poon N.Y.E., Hao B., Guan D., Li J., Lu J., Yang Y., Wu B., Webb S.E., WU C.M., Miller A.L., Liang Y., Yao X., Wang J., Yan B. and Boheler K.R., Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, Cardiovascular Research. London, Oxford, 2018, 114: 894-906.

Poon N.Y.E., Mature cardiomyocytes from human pluripotent stem cells for drug screening and disease modeling, Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Wang J., Cui C., Nan H., Yu Y., Xiao Y., Poon N.Y.E., Yang G., Wang X., Wang C., Li L., Boheler K.R., Ma X., Cheng X., Ni Z. and Chen M., Graphene Sheet-Induced Global Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells, ACS Applied Materials & Interfaces. 2017, 9: 25929-25940.

Researcher : Qian C

Project Title:	Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Structural & Mechanistic Analysis of BAF Chromatin Remodeling Complex
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2015

Project Title:	New Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation
Investigator(s):	Qian C, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Drug development targeting a novel protein complex in rRNA transcription
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Identification and characterization a novel protein complex in rRNA transcription
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

DU Y., Xie S., Huang H.A.O., Wang X.I.N. and Qian C., Characterization of a Novel Protein Complex in Ribosomal RNA Transcription, The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Qian C., Maintaining Genome Stability during Replication: A structural perspective. 2018.

Researcher : RAO Y

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu J., Rao Y., Cheung M., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheak K., Sharma R., Hodgson L. and Cheung M., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, Nat Commun . 2017.

RAO Y., A dual role for DLC1 in regulating avian cranial neural crest cell fate commitment and delamination, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

RAO Y., Cheung M.P.L., Liu A.J., Sharma R. and Cheung M.C.H., A dual role for DLC1 in regulating avian cranial neural crest cell fate commitment and delamination, The Hong Kong Inter-University Postgraduate Symposium in Biomedical Sciences. 2018.

RAO Y., Distinct modes of DLC1 function regulate avian cranial neural crest cell fate commitment and delamination, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

RAO Y., Cheung M.P.L. and Cheung M.C.H., Distinct modes of DLC1 function regulate avian cranial neural crest cell fate commitment and delamination, The 22nd Research Postgraduate Symposium, The University of Hong Kong. 2017.

Researcher : RUVEN C

List of Research Outputs

RUVEN C., BADEA S.-.R., Wong W.M. and Wu W., Combination Treatment With Exogenous GDNF and Fetal Spinal Cord Cells Results in Better Motoneuron Survival and Functional Recovery After Avulsion Injury With Delayed Root Reimplantation, Journal of Neuropathology & Experimental Neurology. 2018, 77: 325-343.

RUVEN C., Transplantation of embryonic spinal cord-derived cells to prevent muscle atrophy after various peripheral nerve injuries (PhD Thesis), The University of Hong Kong. 2017.

Researcher : SHIU CC

List of Research Outputs

FRASER L.A., Kinghorn A.B., SHIU C.C., Serrano C.M., McClendon M.T., Stupp S.I. and Tanner J.A., Development of an instrument-free microfluidic biosensor for malaria diagnosis, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Figueroa M.G., Feng L., SHIU C.C., Dirkzwager R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhauser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017, University of Marburg, Germany. 2017.

Figueroa-Miranda G., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhausser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Sensors and Actuators B: Chemical. 2018, 255: 235-243.

Kinghorn A.B., FRASER L.A., LIANG S., SHIU C.C. and Tanner J.A., Aptamer Bioinformatics, International Journal of Molecular Sciences. 2017.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C. and Tanner J.A., Aptamer integrated DNA nanoswitch for heterogeneous recognition, 2017 HKUST-Tsinghua Molecular Architecture Design Form, Hong Kong University of Science & Technology, Hong Kong. 2017.

SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017.

SHIU C.C. and Tanner J.A., Aptamers in DNA nanostructures: tweezers, boxes and lattices, Global Young Scientists Summit 2018, Singapore. 2018.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

SHIU C.C. and Tanner J.A., Biomolecule detection by 2D DNA tile nanostructure formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences in 2018.

SHIU C.C. and Tanner J.A., Target-Induced Formation of DNA Lattices for Signal Amplification, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : SIT HM

List of Research Outputs

SIT H.M., Cofilin in mechanosensitive podosomes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : SO HF

List of Research Outputs

SO H.F., Glucose-regulated expression of PDZD2/sPDZD2: functional relevancy in islets, insulinoma cells and adipocytes (PhD Thesis), The University of Hong Kong. 2017.

Researcher : SO KH

List of Research Outputs

SO K.H., Energy Management in Hypertrophic Chondrocyte under ER Stress (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : SO PY

List of Research Outputs

Chan W.L., Lai W.L., SO P.Y. and Ching Y.P., Oncogenic role of CD133 in Hepatocellular Carcinoma, In: merican Association for Cancer Research (AACR), American Association for Cancer Research (AACR), Annual Meeting, Apr. 2018, Chicago, USA. 2018.

Researcher : See CYH

List of Research Outputs

See C.Y.H., Best Oral Research Presentation, Asian Medical Education Association (AMEA) Conference, 13th December 2017, Hong Kong. . 2017.

See C.Y.H., LAU T.H.S., SUN W.H., Choi W.Y.K. and Wong W.C.W., Crowdsourcing for Digital Learning, Centre for Information Technology in Education Research Symposium (CITERS 2018, HKU). 2018.

See C.Y.H., Invited Symposium Lecture: Research Methods in Medical Education, The Hong Kong Academy of Medicine Annual Medical Education Conference. 2018.

See C.Y.H., Ng E., Fong D.Y.T., Lau W.C.S. and Lam T.P., Medical Student Peer-created E-learning Resources in Social Media: A Mixed-Methods Study. , Asian Medical Education Association (AMEA) Conference, 13th December 2017, Hong Kong.. 2017.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	The roles of N-Myc, Sufu and Gli genes in regulating the dynamic progression of mammalian cochlear hair cell differentiation
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	The role of Sox10 in controlling cell-cell and cell-matrix interactions during mouse enteric nervous system development
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2017
Completion Date:	11/2017

List of Research Outputs

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A.F.Y., Wong J.Y.H., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Free Paper Presentation - Poster Audience Award, Asian Medical Education Association. 2017.

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Stress and its impact on learning: a snapshot of first year health sciences students in the Li Ka Shing Faculty of Medicine, Ninth Asia Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education . 2017.

PAN W., HOR C., Hui C.C. and Sham M.H., Suppressor of fused (Sufu) and Spop orchestrate Gli2/3 functions to regulate mammalian hindbrain neural progenitor development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.-.H., Wynn S., Mak A...C...Y..., Chan W...Y..., Jauch R., Fritzsch B., Lovell-Badge R., Sham M.H. and Cheah K.S.E., Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis, Molecular Biology of Hearing and Deafness 2018.

WANG L., ZHANG H. and Sham M.H., Unravelling a Eya1-Notch axis in epibranchial placode differentiation during craniofacial morphogenesis, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

ZHANG H., WANG L., Wong Y.M.E., Tsang S.L., Xu P.X., Lendahl U. and Sham M.H., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis, eLife. 2017, 6: e30126.

Researcher : Shea GKH

List of Research Outputs

Cai S., Shea G.K.H., Shum D.K.Y. and Chan Y.S., Use of human iPSC-derived sensory neurons to switch human bone marrow-derived Schwann cells to fate commitment, Methods in Molecular Biology Series. 2018, 1739: 149-160.

Lam G., Shum D.K.Y., Chan Y.S. and Shea G.K.H., Transplantation of autologous human bone marrow-derived neural/glial progenitors in critical subacute window for repair of the injured spinal cord, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P16. 2018.

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Researcher : Shiu SYW

Project Title:	Exploring melatonin receptor signaling in human retinal pigment epithelial cells
Investigator(s):	Shiu SYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	03/2018

List of Research Outputs

Ma C.W., Chu J.Y.S., Chan Y.S. and Shiu S.Y.W., Integrated life science education in Bachelor of Nursing and Bachelor of Chinese Medicine at The University of Hong Kong, The 9th Asian Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education, PP54. 2017.

WONG L.H., Shiu S.Y.W. and Yao K.M., Regulation of TNFα-induced insulin resistance in adipocytes by melatonin and PDZD2/sPDZD2, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Cell-based therapy for congenital myelin disorders of the central nervous system
Investigator(s):	Shum DKY, Chan YS, Shea GKH, Tu W, Tsui YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2018

List of Research Outputs

Cai S., Tsui Y.P., Tam K.W., Shea G.K.H., Chang R.S.K., Ao Q., Shum D.K.Y. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells, Stem Cell Reports. Cambridge, MA, Cell Press, 2017, 9: 1097-1108.

Cai S., Shea G.K.H., Shum D.K.Y. and Chan Y.S., Use of human iPSC-derived sensory neurons to switch human bone marrow-derived Schwann cells to fate commitment, Methods in Molecular Biology Series. 2018, 1739: 149-160.

Chan Y.S., JIANG Q., Lai S.K., Wu L.K., Ma C.W. and Shum D.K.Y., Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation. Bulletin of Japan Soc Neurochemistry 56(2) : 119, [ 60^th Conference of Japan Society for Neurochemistry. Sendai, Japan. Sept. 7-9, 2017]. 2017.

Chan Y.S., KWAN P.Y., Ma C.W. and Shum D.K.Y., Emerging role of perineuronal chondroitin sulfates and semaphorin 3A on the developing vestibular circuitry, Proc. 1^st International Conference on the Glycobiology of Nervous System p.40 [BK21PLUS Lecture. Seoul, Korea. Sept. 2-5, 2017]. 2017.

Chan Y.S., Shi W., Wu L.K., Ma C.W. and Shum D.K.Y., Endocannabinoid-mediated modulation of sensorimotor circuits for the navigational system, [12^th Biennial Conference of Chinese Neuroscience Society. Tianjin Oct. 12-15, 2017]. 2017.

Chan Y.S., Han L., Li Y.H., Wu L.K. and Shum D.K.Y., Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors, Soc. Neuroscience Abstract (USA), 286.23 [Washington DC. Nov. 12-16, 2017]. 2017.

Chan Y.S., JIANG Q., Shi W. and Shum D.K.Y., The engagement of GABA receptors in tuning navigational behavior., [ 38^th Congress of International Union of Physiological Sciences Rio de Janeiro, Brazil. Aug. 1-5, 2017]. 2017.

Chow W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system., Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. 2017.

Ho S.N., Wu L.K., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Identification of perineuronal net-associated plastic factors, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P39. 2018.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 61. 2017.

JIANG Q., Wu L.K., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of your adult rats by fluoxetine, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P12. 2018.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. 2017.

KWAN P.Y., JIANG Q., CHUA W.H., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal nets - associated semaphoring 3A impacts on vestibular-dependent behaviour, /Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P44. 2018.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 63. 2017.

Kwok L.F., Soo Z.K., Tam K.W., Shum D.K.Y. and Chan Y.S., Use of chondroitinase ABC-chitosan microbeads for treatment of spinal cord injury in rat, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P17. 2018.

Lam G., Shum D.K.Y., Chan Y.S. and Shea G.K.H., Transplantation of autologous human bone marrow-derived neural/glial progenitors in critical subacute window for repair of the injured spinal cord, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P16. 2018.

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Li Z.H., Chan Y.S. and Shum D.K.Y., Activity regulated neuronal trafficking of heparanase 1. Abstracts of 12^th Int’l Symp. on Healthy Aging, Science and Aging – Wellness and Longevity: From Science to Service : 50 [HK. March 11-12, 2017]. 2017.

Lyn Q., Fan R., Zhao J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization induced iPSC-derived cortical neurons through genome editing, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells for use in transplantation therapy., Proc. 38^th Int’l Congress of International Union of Physiological Sciences 02.049. [Rio de Janeiro, Brazil. August 1-5, 2017]. 2017.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow - implications for remyelination therapy, Soc. Neuroscience Abstract (USA) 475.14. 2017.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC treatment induces macrophage polarisation to anti-inflammatory state in central nervous system, 13th International Symposium on Healthy Aging “Aging‧Health‧Happiness” . 2018.

Tam K.W., Chan Y.S. and Shum D.K.Y., Macrophage polarisation to anti-inflammatory state in central nervous system after chondroitinase ABC treatment, 7 Lakes Proteoglycans International Conference. 2017.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 81. 2017.

Tsui Y.P., Wu L.K., Chan Y.S. and Shum D.K.Y., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Abstracts of XIII European Meeting on Glial Cells in Health & Disease, GLIA 2017 ; T02-006A. Glia 65(S1) E116[Edinburgh. July 8-11, 2017]. 2017.

Wan V.W., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Assessing the role of inhibitory interneurons in motor learning., Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P6. 2018.

Wong C.N., Shum D.K.Y. and Chan Y.S., Effect of heparanase 2 protein on hippocampal neuron synaptic plasticity, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P4. 2018.

Yip H.M., Kwok L.F., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cell-seeded chitosan nanofibers for nerve regeneration, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P14. 2018.

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease
Investigator(s):	Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese
Investigator(s):	Song Y, Sham PC, Fan Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	07/2017

Project Title:	Study of the pathogenic mechanisms of Hnrnpa1 in congenital heart defects (CHD)
Investigator(s):	Song Y, Lian Q, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Investigation of the roles of HNRNPA1 in the maintenance of motor neurons
Investigator(s):	Song Y, Cheung MCH, Ho WL, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016
Completion Date:	02/2018

Project Title:	Mapping a locus on chromosome 17 controlling endoplasmic reticulum stress and defence response in mice
Investigator(s):	Song Y, Yeung ML, Bao S
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Functional analysis of a human familial Adolescent Idiopathic Scoliosis (AIS) mutation in a mouse model
Investigator(s):	Song Y, Luk KDK, Gao B, Cheung JPY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Gao W.J., Chen C., Zhou T.F., Yang S.L., Gao B., Zhou H., Lian C.J., Wu Z.Z., Qiu X.J., Yang X.M., Alattar E., Liu W.T., Su D.Y., Chen Y.L., Song Y., Luk K.D.K., Chan D., Sham P.C., Xing C., Khor C.C., Liu G., Yang J.L., Deng Y.B., Hao D.J., Huang D.S., Li Q.Z., Xu C.X. and Su P.Q., Rare coding variants in mapk7 predispose to adolescent idiopathic scoliosis, Human Mutation. 2017, 38: 1500-1510.

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : Sy MH

Project Title:	Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0
Investigator(s):	Sy MH, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	The role of DNA Damage and Repair Signaling in Hepatocarcinogenesis
Investigator(s):	Sy MH, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	Ubiquitin and SUMO: From molecular mechanisms to system-wide responses; Stabilization of imprinted retrotransposon-derived gene PEG10 by deubiquitinase USP9X
Investigator(s):	Sy MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, Embo Conference: Ubiquitin And Sumo: From Molecular Mechanisms To System-wide Responses 2017.

Researcher : Szeto YY

Project Title:	Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear
Investigator(s):	Szeto YY, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	11th Molecular Biology of Hearing and Deafness Conference; Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis
Investigator(s):	Szeto YY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

List of Research Outputs

Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.-.H., Wynn S., Mak A...C...Y..., Chan W...Y..., Jauch R., Fritzsch B., Lovell-Badge R., Sham M.H. and Cheah K.S.E., Cooperation between SOX9 and SOX10 is required for hearing via regulation of genes involved in inner ear fluid homeostasis, Molecular Biology of Hearing and Deafness 2018.

Researcher : TANG SLM

List of Research Outputs

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

Researcher : TANG WC

List of Research Outputs

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : TANG X

List of Research Outputs

MING X., Zhang X., CAO T., ZHANG L., QI J., TANG X., CUI Y., Zhang B., Li Y., Qin Y. and Guan X., RHCG suppresses tumorigenicity and metastasis in esophageal squamous cell carcinoma via inhibiting NF-κB signaling and MMP1 expression, Theranostics. 2018, 8: 185-198.

Researcher : Tai CP

List of Research Outputs

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification Of Subpopulations And Molecular Signatures Of Enteric Neural Crest Via Single Cell Transcriptomics, Keystonesymposia T3: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering, Hong Kong, 15-19 Oct 2017.

Lu J., Chen P., Tai C.P., Tam P.K.H. and Cheah K.S.E., Identification of a novel enteric neural crest derived population in the developing mouse gut (Poster Presentation), The 5th International Symposium on Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy, Boston, U.S.A., 8-11 April 2018.

Researcher : Tam KW

List of Research Outputs

Cai S., Tsui Y.P., Tam K.W., Shea G.K.H., Chang R.S.K., Ao Q., Shum D.K.Y. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells, Stem Cell Reports. Cambridge, MA, Cell Press, 2017, 9: 1097-1108.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 63. 2017.

Kwok L.F., Soo Z.K., Tam K.W., Shum D.K.Y. and Chan Y.S., Use of chondroitinase ABC-chitosan microbeads for treatment of spinal cord injury in rat, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P17. 2018.

Lau Y.T., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design., Colloids Surf B Biointerfaces.. 2018, 162: 126-134.

Lau Y.T.C., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells for use in transplantation therapy., Proc. 38^th Int’l Congress of International Union of Physiological Sciences 02.049. [Rio de Janeiro, Brazil. August 1-5, 2017]. 2017.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow - implications for remyelination therapy, Soc. Neuroscience Abstract (USA) 475.14. 2017.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC treatment induces macrophage polarisation to anti-inflammatory state in central nervous system, 13th International Symposium on Healthy Aging “Aging‧Health‧Happiness” . 2018.

Tam K.W., Chan Y.S. and Shum D.K.Y., Macrophage polarisation to anti-inflammatory state in central nervous system after chondroitinase ABC treatment, 7 Lakes Proteoglycans International Conference. 2017.

Yip H.M., Kwok L.F., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cell-seeded chitosan nanofibers for nerve regeneration, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P14. 2018.

Researcher : Tam V

List of Research Outputs

Tam V., Chan W.C.W., Leung V.Y.L., Cheah K.S.E., Cheung K.M.C., Sakai D., McCann M., Bedore J., Séguin C.A. and Chan D., Histological and reference system for the analysis of mouse intervertebral disc, Journal of Orthopaedic Research. 2017.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Tan Z

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

Researcher : Tang HMV

List of Research Outputs

Gao W., Tang H.M.V., Cheng Y., Chan C.P., Chan C.P. and Jin D., Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018, 1861: 211-223.

Researcher : Tang SLM

List of Research Outputs

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2005

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics
Investigator(s):	Tanner JA, Watt RM
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells
Investigator(s):	Tanner JA, Shum HC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Development of an aptamer-based sensor for monitoring luteinizing hormone pulsatility
Investigator(s):	Tanner JA, Li RHW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Outstanding Young Researcher Award 2015-16
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	11/2016

Project Title:	Expanding the functional repertoire of nucleic acid aptamers by fluorescence-activated droplet sorting
Investigator(s):	Tanner JA, Shum HC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Using unnatural base pairs from an expanded genetic code to achieve nested chain terminating PCR for applications in highly multiplexed DNA amplification
Investigator(s):	Tanner JA, Kinghorn AB
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	03/2018

Project Title:	Next Generation Aptamer - Mediated Rapid Diagnostic Tests for the Point-of-Care Diagnosis of Malaria
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	The Shirley Boyde Trust - General Award
Start Date:	09/2017

Project Title:	Aptamers in Bordeaux 2017; Aptamers for Malaria Diagnosis: Structure, Application and Opening the Nano Toolbox
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	Outstanding Research Student Supervisor Award 2016-17
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2018

Project Title:	A comparative study of unnatural base modifications in nucleic acid aptamers for a new generation of high-affinity molecular recognition reagents
Investigator(s):	Tanner JA, Kinghorn AB, Cheung YW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Aptamer-mediated electrochemical biosensing for diagnostics
Investigator(s):	Tanner JA, Cheung YW, Kinghorn AB
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2018

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

Cheung Y.W., Wong A.W.C., Röthlisberger P., Hollenstein M. and Tanner J.A., Aptamer selection using exotic nucleic acid for targeting Plasmodium falciparum lactate dehydrogenase, Aptamer 2018, 5th Oxford Symposim on Aptamer. 2018.

Cheung Y.W., Wong A.W.C., Rothlisberger P., Hollenstein M. and Tanner J.A., Aptamer selection using exotic nucleic acid for targeting Plasmodium falciparum lactate dehydrogenase, Aptamers 2018, 5th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2018.

Cheung Y.W., Tanner J.A. and Kinghorn A.B., In: Julian A. Tanner, Andrew B. Kinghorn, Yee-Wai Cheung, International Journal of Molecular Sciences, Special Issue: Aptamer. 2017.

FRASER L.A., Kinghorn A.B., SHIU C.C., Serrano C.M., McClendon M.T., Stupp S.I. and Tanner J.A., Development of an instrument-free microfluidic biosensor for malaria diagnosis, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Figueroa M.G., Feng L., SHIU C.C., Dirkzwager R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhauser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017, University of Marburg, Germany. 2017.

Figueroa-Miranda G., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhausser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Sensors and Actuators B: Chemical. 2018, 255: 235-243.

Gan W., Zhang C., Siu K.Y., Satoh A., Tanner J.A. and Yu S., ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic, BMC Cell Biology. 2017, 18: 22.

JINATA C., Kinghorn A.B., Cheung Y.W. and Tanner J.A., Design, optimization, and application of a target-free immobilization DNA aptamer selection approach against fluorophores, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

JINATA C., Kinghorn A.B. and Tanner J.A., Optimization of Graphene Oxide-Mediated DNA Aptamer Selections Against Fluorophores, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

KHONG M.L., Li L., Solesio M.E., Lang C.Y.P., Pavlov E. and Tanner J.A., Polyphosphate Mediates Protein Folding in Human Osteoblasts, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

KHONG M.L., Li L., Solesio M.E.T., Lang C.Y.P., Evgeny P. and Tanner J.A., Polyphosphate: a mediator of protein folding in osteoblasts, 42nd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology. 2017.

Kinghorn A.B., Tang Y.H., Shum H.C. and Tanner J.A., An efficient droplet-based nucleic acid amplification method for directed evolution of functional nucleic acids, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Kinghorn A.B., FRASER L.A., LIANG S., SHIU C.C. and Tanner J.A., Aptamer Bioinformatics, International Journal of Molecular Sciences. 2017.

Kinghorn A.B., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C. and Tanner J.A., Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif, Aptamers in Bordeaux. 2017.

Kinghorn A.B. and Tanner J.A., Selective Phenome Growth Adapted NK Model: A Novel Landscape to Represent Aptamer Ligand Binding , Complexity. 2017, 2017: 6760852, 1-12.

LIANG S., Dirkzwager R.M. and Tanner J.A., 3D rapid prototyping aptamer-based malaria diagnostic device, 1st China Forum on Biosensors, Biochips and Nanobiotechnology (BBN China 2017), Foshan, Guangdong, China. 2017.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Automated electrochemical sensing system for monitoring luteinizing hormone pulsatility, Aptamers 2018, 5th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2018.

LIANG S., Kinghorn A.B., Dhillo W., Cass A.E.G. and Tanner J.A., Continuous flow electrochemical sensing systems for monitoring luteinizing hormone pulsatility by oligonucleotide aptamer structure switching, Oligo 2018: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2018.

LIU M., Yu Y.Y., Choi N.T.V., Cheung Y.W. and Tanner J.A., Inhibitory effects of apt21 and apt25 on the enzymatic activity of ADAMTS-5, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

SHIU C.C., TANG S.L.M., Dirkzwager R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Aptamer functionalized DNA origami for protein detection, DNA topoisomerases and DNA topology EMBO Workshop, Les Diablerets, Switzerland. 2017.

SHIU C.C. and Tanner J.A., Aptamer integrated DNA nanoswitch for heterogeneous recognition, 2017 HKUST-Tsinghua Molecular Architecture Design Form, Hong Kong University of Science & Technology, Hong Kong. 2017.

SHIU C.C., DIRKZWAGER R.M., Cheung Y.W., Tanner J.A., Schoning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, Engineering of Functional Interfaces (EnFI) 2017.

SHIU C.C. and Tanner J.A., Aptamers in DNA nanostructures: tweezers, boxes and lattices, Global Young Scientists Summit 2018, Singapore. 2018.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., Aptamers integrated in nucleic acid nanostructure scaffolds for malaria diagnosis, DNA topoisomerases and DNA topology LS2 Satellite Meeting, Les Diablerets, Switzerland. 2017.

SHIU C.C. and Tanner J.A., Biomolecule detection by 2D DNA tile nanostructure formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences in 2018.

SHIU C.C. and Tanner J.A., Target-Induced Formation of DNA Lattices for Signal Amplification, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Tanner J.A., A collaborative team-based two-stage examination in biomedical sciences: design and evaluation, Association for Medical Education in Europe (AMEE) 2017.

Tanner J.A., Aptamer-based Biosensing: Challenges and Opportunities, Biosensors 2018 29th World Congress, Miami, Florida, USA. 2018.

Tanner J.A., Aptamers for malaria diagnosis: structure, application and opening the nano toolbox, Aptamers in Bordeaux. 2017.

Tanner J.A., Are aptamers better? Learning from malaria diagnosis, Aptamers 2018, 5th Oxford Symposium on Aptamers, University of Oxford, United Kingdom . 2018.

Tanner J.A., Enabling collaboration during written examinations: a pilot study in a biomedical science examination, 9th AMEA Symposium cum Frontiers in Medical and Health Sciences Education “Preparing Healthcare Learners for a Changing World”, Hong Kong. 2017.

Tanner J.A., How best improve learning in medicine? The importance of medical education research, 4th Medical Education Conference – Cultivating Professionalism and Research in Medical Education, Hong Kong Academy of Medicine, Hong Kong. 2018.

Tanner J.A., Nucleic acid Aptamers – versatile tools for a new bionanomedicine, Chinese University of Hong Kong. 2018.

Tanner J.A., Outstanding Research Student Supervisor Award 2016-2017, The University of Hong Kong. 2018.

Tanner J.A. and Cheung Y.W., Sandwich and species-specific nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis, PCT International Application. 2017.

Tanner J.A., The University of Hong Kong Outstanding Young Researcher Award 2017, 2017.

Tucker W.O., Cheung Y.W., FRASER L.A., Kinghorn A.B. and Tanner J.A., Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1, International journal of molecular sciences. 2018, 19(3): 763.

Researcher : Tipoe GL

Project Title:	23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Project Title:	Therapeutic effects of Wolfberry (Lycium barbarum polysaccharides; LBP) in non-alcoholic fatty liver disease (NAFLD) animal models
Investigator(s):	Tipoe GL, So KF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Novel anti-hepatic cancer properties of garlic-derived SAMC through direct targeting of LRP6/Wnt signaling pathway
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	07/2017

Project Title:	Defining the protective functional role of cyclooxygenase-1 in acute and chronic liver diseases
Investigator(s):	Tipoe GL, Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	Mechanisms underlying the ameliorative effects of chronic aerobic exercise in non-alcoholic steatohepatitis
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

List of Research Outputs

Tipoe G.L., Ho S.P. and Wong P.W.L., Cadaveric Clinical Workshops for Postgraduate Residency Training for the Professional Specialties and Societies with the School of Biomedical Sciences (SBMS), The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2017, 77.

Tipoe G.L. and Fan K.M.J., Clinical Anatomy Workshop on Acute Abdomen for Surgical Residents at School of Biomedical Sciences, The University of Hong Kong in Collaboration with the College of Surgeon of Hong Kong, 9th Asian Medical Education Association: Preparing Health care Learners for a Changing World. Hong Kong, 2017, 89.

Tipoe G.L., Lau C.S. and Chan Y.S., Integrated Basic Science and Inter-personal Education In Bachelor of Pharmacy at The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2017, 89.

Tipoe G.L., Lau C.S. and Chan Y.S., Integrated basic sciences and inter-professional education in Bachelor of Pharmacy at The University of Hong Kong, 9^th Asian Medical Education Association Conference, PP81. [HK. Dec 14-16, 2017]. 2017.

Tipoe G.L., Chan Y.S. and Lau C.S., Multiple pathways for Biomedical Sciences at the School of Biomedical Sciences, The University of Hong Kong, 9^th Asian Medical Education Association Conference, PP83. [HK. Dec 14-16, 2017]. 2017.

Wang F., Tipoe G.L., Yang C., Nanji A.A., Hao X., So K.F. and Xiao J., Lycium barbarum Polysaccharide Supplementation Improves Alcoholic Liver Injury in Female Mice by Inhibiting Stearoyl-CoA Desaturase 1 , Molecular Nutrition & Food Research. 2018, 1800144.

Xiao J., Xing F., Liu Y., Lv Y., Wang X., Ling M.T., Gao H., Ouyang S., Yang M.I.N., Zhu J., Xia Y., So K.F. and Tipoe G.L., Garlic-derived compound S -allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway, Acta Pharmaceutica Sinica B. 2017.

Xiao J., Yi L.V., Jin F., Liu Y., Ma Y., Xiong Y., Liu L., Zhang S., Sun Y., Tipoe G.L., Hong A., Xing F. and Wang X., LncRNA HANR Promotes Tumorigenesis and Increase of Chemoresistance in Hepatocellular Carcinoma, Cellular Physiology and Biochemistry. 2017, 43: 1926-1938.

YU Q., XIA Z., Liong E.C., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine and Chronic Aerobic Exercise Improve Insulin Sensitivity and Modulate Nrf2 and NF-κB/IκBα Pathways in the Skeletal Muscle of a Non-Alcoholic Fatty Liver Disease Animal Model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Zou L.L., Zhang R., Gao H., Xiao J. and Tipoe G.L., Garlic and Liver Diseases, In: Vinood Patel and Rajkumar Rajendram, The Liver: Oxidative Stress and Dietary Anitoxidants. United Kingdom, Elsevier Academic Press, 2018, 337-347.

Researcher : Tong M

List of Research Outputs

CHE N., Tong M., Ng K.Y., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterization of PRMT6-Regulated Autophagy in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

LUK T.C.S., Tong M., Ng K.Y., Yip K.Y.L., Guan X. and Ma S.K.Y., Role of REX1 Down-Regulation in Promoting Cancer Stemness Properties in Hepatocellular Carcinoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Ng K.Y., Chan J.L.H., Chai S., Tong M., Guan X., Lee N.P.Y., Yuan Y.F., Xie D., Lee T.K., Dusetti N.J., Carrier A. and Ma S.K.Y., TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma, Cancer Research. 2017, 77(17): 4602-4612.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Tsang CM

Project Title:	The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	10/2017

Project Title:	Potentiation of tumor-associated macrophages (TAMs)-induced invasiveness in EBV-associated nasopharyngeal epithelial cells
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2015
Completion Date:	09/2018

Project Title:	The importance of EBV miR-BARTs in promoting the in vivo tumor growth of nasopharyngeal carcinoma by managing apoptotic responses under metabolic stress
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016
Completion Date:	09/2018

Project Title:	The interaction of berberine with chemodrugs for treating EBV-associated carcinomas: the concern for lytic reactivation in affecting the drug efficacy
Investigator(s):	Tsang CM, Tsao GSW, Chiang AKS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Development of molecular probes for surface markers on LMP1-positive nasopharyngeal cancer cells using aptamers selected by cell-SELEX
Investigator(s):	Tsang CM, Tsao GSW, Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2018

List of Research Outputs

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Tsao G.S.W., Tsang C.M. and Lo K.W., Epstein–Barr virus infection and nasopharyngeal carcinoma, Philosophical Transactions of the Royal Society B: Biological Sciences. 2017.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Vérillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation, Laboratory Investigation. 2018, 98: 1093-1104.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Jia L.J., Tsang C.M. and Tsao G.S.W., EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma, Advances in Experimental Medicine and Biology. Springer, 2017, 1018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Tsang KY

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Ng V.C.W., Cheung K.M.C., Tan Z., Boot-Handford R., Boyde A., Cheah K.S.E. and Chan D., Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia, Human molecular genetics. 2017.

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

Researcher : Tsang SL

List of Research Outputs

ZHANG H., WANG L., Wong Y.M.E., Tsang S.L., Xu P.X., Lendahl U. and Sham M.H., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis, eLife. 2017, 6: e30126.

Researcher : Tsao GSW

Project Title:	The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Lan HY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2014
Completion Date:	12/2018

Project Title:	Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Establishment of a shared live cell imaging platform for super-resolution microscopy
Investigator(s):	Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Major Equipment Project
Start Date:	06/2015

Project Title:	Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Summer Courses
Start Date:	07/2015

Project Title:	Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	Role of IL-6/IL-6Rα signaling activation in supporting persistent EBV infection in premalignant nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Deng W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	High speed and high-sensitivity fluorescent live cell imaging system
Investigator(s):	Tsao GSW, Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	Preclinical evaluation of therapeutic use of a selective cdk4/6 inhibitor (PD-0332991) in nasopharyngeal carcinoma (NPC).
Investigator(s):	Tsao GSW, Lui WYV, Lee WMA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	Regulation and pathogenic role of latent infection of Epstein-Barr virus in nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Chen H, Jin D, Kok KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

Project Title:	Deciphering multiple mechanisms underlying the retention of Epstein-Barr viruses in nasopharyngeal carcinoma cells
Investigator(s):	Tsao GSW, Deng W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	American Association for Cancer Research Annual Conference 2018; Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling pathway to reprogram glucose metabolism in nasopharyngeal epithelial cell
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Chen Y.J., Chen Y.L., Chang Y., Wu C.C., Ko Y.C., Tsao G.S.W., Chen J.Y. and Lin S.F., Epstein-Barr Virus Rta-Mediated Accumulation of DNA Methylation Interferes with CTCF Binding in both Host and Viral Genomes, Journal of virology. 2017.

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated Histone Modifications in the Regulation of DNA Damage Repair Members Resulting in Cisplatin Resistance in Nasopharyngeal Carcinoma., Gordon Research Conference on Nasopharyngeal Carcinoma. Hong Kong, June 24-29, 2018.. 2018.

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated Histone Modifications in the Regulation of DNA Damage Repair Members in Nasopharyngeal Carcinoma., The 76th Annual Meeting of the Japanese Cancer Association, Tokyo, Japan. Sept 28-30, 2017.. 2017.

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

Liu J., Lv L., Gong J., Tan Y., ZHU Y., Dai Y., Pan X., Huen M.S.Y., Li B., Tsao G.S.W., Huo J. and Cheung A., Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma, International Journal of Cancer. 2017.

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Tiwari A., Cheung S.T., Deng W., Fong D.Y.T. and Tsao G.S.W., Effect of a qigong intervention on telomerase activity of Chinese women survivors of intimate partner violence: a single-blind, waitlist, randomised controlled trial, The Lancet–CAMS Health Summit. 2017.

Tsao G.S.W., EBV infection of nasopharyngeal epithelial cells, Gordon Research Conference (Cell Growth and Proliferation). 2017.

Tsao G.S.W., Tsang C.M. and Lo K.W., Epstein–Barr virus infection and nasopharyngeal carcinoma, Philosophical Transactions of the Royal Society B: Biological Sciences. 2017.

Verhoeven R.J.A., TONG S., Zong J., Chen Y., Tsao G.S.W., Pan J. and Chen H., NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression, Cancers. Basel, Switerland, MDPI, 2018, 10(4): 119.

Yang J., Machado M.D., Tsao G.S.W. and Chung S.K., A hybrid between classic and innovation: histology education in MBBS Curriculum of HKU LKS Faculty, The XXV International Symposium on Morphological Sciences. 2017.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Vérillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation, Laboratory Investigation. 2018, 98: 1093-1104.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Jia L.J., Tsang C.M. and Tsao G.S.W., EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma, Advances in Experimental Medicine and Biology. Springer, 2017, 1018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : Tse CL

List of Research Outputs

Tse C.L., Herlea-Pana O., Brobst D., Yang X., Wood J., Hu X., Liu Z., Lee C.W., Zaw A.M., Chow B.K.C., Ye K. and Chan C.B., Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle, Diabetes. 2017, 66: 1858-1870.

Researcher : Tse WW

List of Research Outputs

Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017.

Researcher : Tsui YP

Project Title:	CiRA 2017 International Symposium; Cell therapy for CNS myelin disorders: Transplantation of bone marrow-derived oligodendrocyte precursors
Investigator(s):	Tsui YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2017
Completion Date:	11/2017

List of Research Outputs

Cai S., Tsui Y.P., Tam K.W., Shea G.K.H., Chang R.S.K., Ao Q., Shum D.K.Y. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells, Stem Cell Reports. Cambridge, MA, Cell Press, 2017, 9: 1097-1108.

JIANG Q., Wu L.K., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of your adult rats by fluoxetine, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P12. 2018.

Lyn Q., Fan R., Zhao J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization induced iPSC-derived cortical neurons through genome editing, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells for use in transplantation therapy., Proc. 38^th Int’l Congress of International Union of Physiological Sciences 02.049. [Rio de Janeiro, Brazil. August 1-5, 2017]. 2017.

Shum D.K.Y., Cai S., Tam K.W., Tsui Y.P. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow - implications for remyelination therapy, Soc. Neuroscience Abstract (USA) 475.14. 2017.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 81. 2017.

Tsui Y.P., Shea G.K.H., Chan Y.S. and Shum D.K.Y., Derivation of Fate-Committed Schwann Cells from Bone Marrow Stromal Cells of Adult Rats., In: Paula V. Monje, Haesun A. Kim, Schwann Cells: Methods and Protocols. Springer, 2018, MIMB, volume 1739: 137-148.

Tsui Y.P., Wu L.K., Chan Y.S. and Shum D.K.Y., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Abstracts of XIII European Meeting on Glial Cells in Health & Disease, GLIA 2017 ; T02-006A. Glia 65(S1) E116[Edinburgh. July 8-11, 2017]. 2017.

Researcher : WANG L

List of Research Outputs

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

WANG L., Novel UHRF1 acetylation modification by Mof has important role in DNA methylation maintenance, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

WANG L., ZHANG H. and Sham M.H., Unravelling a Eya1-Notch axis in epibranchial placode differentiation during craniofacial morphogenesis, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

ZHANG H., WANG L., Wong Y.M.E., Tsang S.L., Xu P.X., Lendahl U. and Sham M.H., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis, eLife. 2017, 6: e30126.

Researcher : WANG L

List of Research Outputs

WANG L., Novel UHRF1 acetylation modification by Mof has important role in DNA methylation maintenance, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : WANG N

List of Research Outputs

WANG N., Molecular Basis of Carpal Tunnel Syndrome, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

YANG W., Garrett L., FENG D., Elliott G., Liu X., WANG N., Wong Y.M., Choi N.T.V., Yang Y. and Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : WONG CN

List of Research Outputs

WONG C.N., Functional studies of mammalian heparanase 2 protein, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Wong C.N., Shum D.K.Y. and Chan Y.S., Effect of heparanase 2 protein on hippocampal neuron synaptic plasticity, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P4. 2018.

Researcher : WONG LH

List of Research Outputs

WONG L.H., Shiu S.Y.W. and Yao K.M., Regulation of TNFα-induced insulin resistance in adipocytes by melatonin and PDZD2/sPDZD2, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

WONG L.H., Regulation of TNFα-induced insulin resistance in adipocytes by melatonin and PDZD2/sPDZD2, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : WONG LYR

List of Research Outputs

Lui P.Y., WONG L.Y.R., HO T.H., Au S.W.N., Chan C.P., Kok K.H. and Jin D., PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. , Journal of Immunology. 2017, 199: 1846-1855.

Researcher : WONG NHM

List of Research Outputs

WONG N.H.M., Suppression of IFN-b production by Epstein-Barr virus lytic transactivator Zta (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : WONG SKK

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

Researcher : WU THE

List of Research Outputs

WU T.H.E., Roles of Cystic Fibrosis Transmembrane Conductance Regulator, Pannexins and Connexins in ATO Relese from Human and Rat Skeletal Muscle (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : Wang C

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Itoh N., Ron D. and Chan D., Mechanisms of chondrocyte adaptation and survival under ER stress, Mechanisms of Development. 2017, 145: S22.

Tan Z., Niu B., Tsang K.Y., Melhado I., Ohba S., He X.J., Huang Y., Wang C., McMahon A., Jauch R., Chan D., Zhang M.Q. and Cheah K.S.E., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions, PLOS Genetics. 2018, 14: e1007346.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : Wang F

List of Research Outputs

Cheng Y., Wang F., Ye Z., Chan C.P., Chan C.P. and Jin D., Identification and characterization of a novel gene faci that alleviates highfat diet-induced metabolic syndrome in mice, The 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and the 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress: Integrating Science for Bio-Health Innovation. Convention and Exhibition Center (COEX), Seoul, Korea, June 4-8, 2018.. 2018.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : Wang JJ

Project Title:	Outstanding Young Researcher Award 2011-12
Investigator(s):	Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2013

Project Title:	Understanding the effects of DNA methylation on gene expression - a computational approach
Investigator(s):	Wang JJ, Wong MP, Chim JCS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

List of Research Outputs

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission in the central vestibular system, Abstracts of International Behavorial Neuroscience Society : [Hiroshima, Japan. June 26-30, 2017]. 2017.

Researcher : Wang Y

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

Wang Y., Jin J., CHUNG W.H., Feng L., Sun H. and Hao Q., Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation, Proceedings of the National Academy of Sciences. 2018, 115: 2365-2370.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells, In: James Adjaye, Stem Cells International. 2018, 2018: 1-11.

Researcher : Wang Y

List of Research Outputs

Wang Y., Liu A.J., Leung K.K.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells., Stem Cells Int.. 2018.

Researcher : Wong ACC

List of Research Outputs

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Researcher : Wong CN

List of Research Outputs

WONG C.N., Functional studies of mammalian heparanase 2 protein, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	Cellular stress responses in cancer cells with impaired glycogen metabolism
Investigator(s):	Wong NS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

Cheng S.S. and Wong N.S., Improving undergraduate learning experience of biochemical techniques by the flipped class approach, Blended Learning Symposium 2018 @PolyU. 2018.

Researcher : Wong PWL

List of Research Outputs

Tipoe G.L., Ho S.P. and Wong P.W.L., Cadaveric Clinical Workshops for Postgraduate Residency Training for the Professional Specialties and Societies with the School of Biomedical Sciences (SBMS), The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2017, 77.

Researcher : Wong SL

Project Title:	Deciphering combinational genetics
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Start-up Allowance for Returning Croucher Award Recipients
Start Date:	05/2016

Project Title:	High-throughput discovery of combination therapies by CombiGEM-CRISPR
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Advancing the development of combinatorial genetics platforms
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	04/2017

Project Title:	Massively parallel discovery of combination therapies for polyglutamine diseases
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2017

Project Title:	Moving towards massively parallel identification of anti-cancer microRNA combinations for hepatocellular carcinoma
Investigator(s):	Wong SL, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Translating Combinatorial Genetics using CombiGEM-CRISPR 2.0
Investigator(s):	Wong SL, Leung SY, Ma SKY, Jin D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Platform Technology Funding
Start Date:	06/2018

List of Research Outputs

Wong S.L., Advanced combinatorial genetics technology for decoding biological complexity, Department of Biomedical Sciences, City University of Hong Kong. 2017.

Wong S.L., Combinatorial Genetics Platforms for Discovery of New Therapeutic Combinations , Department of Chemical Pathology, Chinese University of Hong Kong. 2018.

Wong S.L., Combinatorial genetics technologies for functional genomics, 5th Macau Symposium on Biomedical Sciences 2018. 2018.

Wong S.L., Moving Towards Massively Parallel Combinatorial Genetics , Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet Scientific Symposium. 2018.

Researcher : Wong SM

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : Wong TL

Project Title:	Role of ASNS in the development of HCC via modulating cancer stemness properties
Investigator(s):	Wong TL, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	04/2017

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

Wong T.L., CHAN L.H. and Ma S.K.Y., Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2, AACR Annual Meeting 2017. 77(13 Suppl): Abstract nr 5416.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Wong WHJ

List of Research Outputs

Beck D., Thoms J.A.I., Palu C., Herold T., Shah A., Olivier J., Boelen L., Huang Y., Chacon D., Brown A., Babic M., Hahn C., Perugini M., Zhou X., Huntly B.J., Schwarzer A., Klusmann J.H., Berdel W.E., Wormann B., Buchner T., Hiddemann W., Bohlander S.K., To L.B., Scott H.S., Lewis I.D., D'Andrea R.J., Wong W.H.J. and Pimanda J.E., A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients, Leukemia. 2018, 32(2): 263-272.

Pijning A.E., Chiu J., Yeo R.X., Wong W.H.J. and Hogg P.J., Identification of allosteric disulfides from labile bonds in X-ray structures, R Soc Open Sci. 2018, 5(2): 171058.

Poulos R.C. and Wong W.H.J., Finding cancer driver mutations in the era of big data research, Biophys Rev. 2018.

Wong W.H.J., Queensland Institute of Medical Research, Australia, Uncovering mutational and DNA repair processes in the search for cis-regulatory mutations in cancer genomes . 2018.

Researcher : Wong WM

List of Research Outputs

RUVEN C., BADEA S.-.R., Wong W.M. and Wu W., Combination Treatment With Exogenous GDNF and Fetal Spinal Cord Cells Results in Better Motoneuron Survival and Functional Recovery After Avulsion Injury With Delayed Root Reimplantation, Journal of Neuropathology & Experimental Neurology. 2018, 77: 325-343.

Researcher : Wong YME

Project Title:	The roles of Eya1 and Six1 transcription factors in regulating the mammalian cochlear hair cell morphogenesis
Investigator(s):	Wong YME, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

Wong Y.M.E., Cdo regulates pillar cell formation in cochlea as transmembrane receptor of Shh signaling, The 15th Australasian Auditory Neuroscience Workshop, Sydney, Australia, 2nd December, 2017.

Wong Y.M.E., Hedgehog co-receptor Cdo negatively regulates inner ear hair cell specification, Association for Research in Otolaryngology, 41st Annual MidWinter Meeting, San Diego, USA, 10-14 February, 2018. 2017.

Wong Y.M.E., Organoids from pluripotent stem cells for patient-specific ear development models, Centre for Cell Therapy and Regenerative Medicine Mid-Winter Research Symposium, Perth, Australia. 2018.

ZHANG H., WANG L., Wong Y.M.E., Tsang S.L., Xu P.X., Lendahl U. and Sham M.H., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis, eLife. 2017, 6: e30126.

Researcher : Wu LK

List of Research Outputs

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Neonatal excitation-inhibition imbalance introduces long-lasting changes to neuronal recruitment in vestibular circuits for spatial navigation, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

CHUA W.H., JIANG Q., Wu L.K. and Chan Y.S., Rescuing developmental deficits in vestibular circuits by combined fluoxetine treatment and sensory training, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P13. 2018.

Chan Y.S., JIANG Q., Lai S.K., Wu L.K., Ma C.W. and Shum D.K.Y., Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation. Bulletin of Japan Soc Neurochemistry 56(2) : 119, [ 60^th Conference of Japan Society for Neurochemistry. Sendai, Japan. Sept. 7-9, 2017]. 2017.

Chan Y.S., Shi W., Wu L.K., Ma C.W. and Shum D.K.Y., Endocannabinoid-mediated modulation of sensorimotor circuits for the navigational system, [12^th Biennial Conference of Chinese Neuroscience Society. Tianjin Oct. 12-15, 2017]. 2017.

Chan Y.S., Han L., Li Y.H., Wu L.K. and Shum D.K.Y., Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors, Soc. Neuroscience Abstract (USA), 286.23 [Washington DC. Nov. 12-16, 2017]. 2017.

Ho S.N., Wu L.K., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Identification of perineuronal net-associated plastic factors, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P39. 2018.

JIANG Q., Wu L.K., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of your adult rats by fluoxetine, Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P12. 2018.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service 81. 2017.

Tsui Y.P., Wu L.K., Chan Y.S. and Shum D.K.Y., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Abstracts of XIII European Meeting on Glial Cells in Health & Disease, GLIA 2017 ; T02-006A. Glia 65(S1) E116[Edinburgh. July 8-11, 2017]. 2017.

Wan V.W., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Assessing the role of inhibitory interneurons in motor learning., Abstracts of 13^th Int’l Symp. on Healthy Aging: Science and Aging –Aging, Health, Happiness P6. 2018.

Researcher : Wu MH

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Hui M.N., Wu M.H. and Cheung M.C.H., Elucidating the roles of SOX9 in human neural stem cells., Keystone Symposium: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (T3). 2017.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

Liu J., Rao Y., Cheung M., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheak K., Sharma R., Hodgson L. and Cheung M., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, Nat Commun . 2017.

Researcher : Wu W

Project Title:	Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury
Investigator(s):	Wu W, Yick LW, So KF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	11/2003

Project Title:	Research Output Prize
Investigator(s):	Wu W, Su H, Wong WM, So KF, Wu EX
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	10/2008

Project Title:	Repairing neural damage after spinal cord injury with self-assembling peptide nanofiber scaffold (SAPNS)
Investigator(s):	Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Enhancing axonal regeneration of spinal motoneurons after root avulsion by manipulation of chondroitin sulfate proteoglycans (CSPGs)
Investigator(s):	Wu W, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016
Completion Date:	04/2019

List of Research Outputs

Li J., Chen S., Zhao Z., Luo Y., Hou Y., LI H., He L., Zhou L. and Wu W., Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection, Frontiers in Cellular Neuroscience. 2017, 11.

RUVEN C., BADEA S.-.R., Wong W.M. and Wu W., Combination Treatment With Exogenous GDNF and Fetal Spinal Cord Cells Results in Better Motoneuron Survival and Functional Recovery After Avulsion Injury With Delayed Root Reimplantation, Journal of Neuropathology & Experimental Neurology. 2018, 77: 325-343.

Wong H.S., Yeung P.K.K., Lai H.M., Lam K.S.L., Wu W. and Chung S.K., Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas: Three-Dimensional Histology of Pancreas by Tissue Clearing, In: Juan S. Bonifacino, Mary Dasso, Joe B. Harford, Jennifer Lippincott-Schwartz, Kenneth M. Yamada, Current Protocols in Cell Biology. Hoboken, NJ, USA, John Wiley & Sons, Inc., 2017, 77: 19.20.1-19.20.10.

Researcher : XIA Z

List of Research Outputs

YU Q., XIA Z., Liong E.C., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine and Chronic Aerobic Exercise Improve Insulin Sensitivity and Modulate Nrf2 and NF-κB/IκBα Pathways in the Skeletal Muscle of a Non-Alcoholic Fatty Liver Disease Animal Model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : XIONG C

List of Research Outputs

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : XU C

List of Research Outputs

XU C., Cytosolic delivery of heterologous antigens via Salmonella type 3 secretion system for prophylactic vaccine development against Staphylococcus aureus infection and mesothelioma metastasis (PhD Thesis), The University of Hong Kong. 2017.

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253.

Researcher : XU H

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

XU H. and Li J., New Insight into Functional Analysis of Structural Variants in Cancer Genome, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : XU W

List of Research Outputs

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

XU W., Apical Fluid Sensing Mechanism of Cultured Pig Tracheal Epitheila (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Xie S

List of Research Outputs

DU Y., Xie S., Huang H.A.O., Wang X.I.N. and Qian C., Characterization of a Novel Protein Complex in Ribosomal RNA Transcription, The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Researcher : Xu W

List of Research Outputs

XU W., Apical Fluid Sensing Mechanism of Cultured Pig Tracheal Epitheila (PhD Thesis), The University of Hong Kong. 2017.

Researcher : YANG W

List of Research Outputs

YANG W., Garrett L., FENG D., Elliott G., Liu X., WANG N., Wong Y.M., Choi N.T.V., Yang Y. and Gao B., Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : YANG X

List of Research Outputs

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Aberrant DNA methylation alters transcriptional program in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia, 59th ASH Annual Meeting and Exposition, December 9-12, 2017, Atlanta, USA. 2017.

YANG X., Altered enhancer activity represses CEBPE expression in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

YANG X., Cheung M.P.L., Wong C.M., Ng I.O.L., Lung H.L. and Cheung M.C.H., Elucidating the role of DLC1, a RhoGTPase-activating protein, in metastatic melanoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253.

Researcher : YANG X

List of Research Outputs

YANG X., Altered enhancer activity represses CEBPE expression in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

Researcher : YANG X

List of Research Outputs

YANG X., Altered enhancer activity represses CEBPE expression in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

Researcher : YEUNG SF

List of Research Outputs

Ching Y.P., CHAN S.H.V. and YEUNG S.F., The role of centrosome over-duplication in liver cancer , In: BIT, 15th Annual Congress of International Drug Discovery Science and Technology - Japan 2017 . Osaka Japan, 2017.

YEUNG S.F., The role of PLK4 in Hepatocarcinogenesis, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YEUNG S.F., Lai W.L. and Ching Y.P., The role of centrosome amplification in HCC, In: AACR, American Association for Cancer Research (AACR), Annual Meeting, April, 2018, Chicago, USA. 2018.

Researcher : YI Y

List of Research Outputs

YI Y., How isoliquiritigenin impact sirtuin family protein's activity, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : YIP SH

List of Research Outputs

YIP S.H., Statistical Analysis of RNA-seq and scRNA-seq Expression Data (PhD Thesis), The University of Hong Kong. 2018.

Researcher : YOU R

List of Research Outputs

YOU R., Investigating Silica Nanoparticles as a Risk Factor of Neurodegeneration (PhD Thesis), The University of Hong Kong. 2017.

Researcher : YU Q

List of Research Outputs

YU Q., XIA Z., Liong E.C., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine and Chronic Aerobic Exercise Improve Insulin Sensitivity and Modulate Nrf2 and NF-κB/IκBα Pathways in the Skeletal Muscle of a Non-Alcoholic Fatty Liver Disease Animal Model, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : YU Z

List of Research Outputs

YU Z., Hnrnpa1 Mutation Cause Congenital Heart Defects (PhD Thesis), The University of Hong Kong. 2017.

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : Yan B

Project Title:	Uncovering combinatorial regulation of transcription factors and microRNAs on cardiomyocyte differentiation from pluripotent stem cells
Investigator(s):	Yan B, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	06/2016
Completion Date:	12/2017

Project Title:	Integrative identification of IRX4 regulatory function in ventricular cardiomyocyte differentiation from human pluripotent stem cells
Investigator(s):	Yan B, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	09/2018

List of Research Outputs

Hong H., Wu H., Chen J., Wu B., Yu H., Yan B. and Liang Y., Cytotoxicity induced by iodinated haloacetamides via ROS accumulation and apoptosis in HepG-2 cells, Environmental Pollution. Elsevier, 2018, 242: 191-197.

Poon N.Y.E., Hao B., Guan D., Li J., Lu J., Yang Y., Wu B., Webb S.E., WU C.M., Miller A.L., Liang Y., Yao X., Wang J., Yan B. and Boheler K.R., Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, Cardiovascular Research. London, Oxford, 2018, 114: 894-906.

Yan B., Guan D., Wang C., Wang J.J., He B., Qin J., Boheler K.R., Lu A., Zhang G. and Zhu H., An integrative method to decode regulatory logics in gene transcription, Nature Communications. 2017, 8: 1044.

Yan B., Big biological data and biomedicine translation, The 2nd international conference of SILKGIS. Chengdu, China, 2018.

Yan B., Wang P., Wang J.J. and Boheler K.R., Discovery of surface target proteins linking drugs, molecular markers, gene regulation, protein networks and disease by using a web-based platform Targets-search, In: Boheler, Kenneth R., Gundry, Rebekah L, Methods in Molecular Biology. Germany, Springer, 2017, 331-344.

Researcher : Yang J

Project Title:	Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions
Investigator(s):	Yang J, So KF, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008

List of Research Outputs

Yang J., Machado M.D., Tsao G.S.W. and Chung S.K., A hybrid between classic and innovation: histology education in MBBS Curriculum of HKU LKS Faculty, The XXV International Symposium on Morphological Sciences. 2017.

Researcher : Yang X

List of Research Outputs

YANG X., Altered enhancer activity represses CEBPE expression in MLL-rearranged leukemia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

YANG X., Cheung M.P.L., Lung H.L. and Cheung M.C.H., An oncogenic role of Deleted in Liver Cancer 1 (DLC1) in metastatic melanoma, American Association for Cancer Research Annual Meeting. 2018.

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion
Investigator(s):	Yao KM, Chan DW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014
Completion Date:	09/2017

Project Title:	Study of Zinc Finger And BTB Domain Containing 33 (ZBTB33) as putative FOXM1-interacting protein in the regulation of cancer cell proliferation
Investigator(s):	Yao KM, Lee CYL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017
Completion Date:	12/2017

Project Title:	The interplay of FOXM1 with PRDM14 and ZBTB33 in the epigenetic regulation of pluripotency in human embryonic stem cells
Investigator(s):	Yao KM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2017
Completion Date:	11/2017

List of Research Outputs

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Doxycycline-terminable intraocular drug delivery cell-encapsulating device, The 33rd Asia-Pacific Academy of Ophthalmology Congress 2018.

WONG L.H., Shiu S.Y.W. and Yao K.M., Regulation of TNFα-induced insulin resistance in adipocytes by melatonin and PDZD2/sPDZD2, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Yeung PKK

Project Title:	The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice
Investigator(s):	Yeung PKK, Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	09/2008

List of Research Outputs

Wong H.S., Yeung P.K.K., Lai H.M., Lam K.S.L., Wu W. and Chung S.K., Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas: Three-Dimensional Histology of Pancreas by Tissue Clearing, In: Juan S. Bonifacino, Mary Dasso, Joe B. Harford, Jennifer Lippincott-Schwartz, Kenneth M. Yamada, Current Protocols in Cell Biology. Hoboken, NJ, USA, John Wiley & Sons, Inc., 2017, 77: 19.20.1-19.20.10.

Researcher : Yip YL

List of Research Outputs

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Vérillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation, Laboratory Investigation. 2018, 98: 1093-1104.

Yip Y.L., Lin W., Deng W., Jia L.J., Lo K.W., Busson P., Verillaud B., Liu X., Tsang C.M., Lung M.L. and Tsao G.S.W., Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Researcher : You C

List of Research Outputs

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Yu B

List of Research Outputs

XU C., ZHANG B., Lin Q., DENG J., Yu B., ARYA S., Yuen K.Y. and Huang J., Live attenuated Salmonella typhimurium Vaccines delivering SaEsxA and SaEsxB via Type III Secretion System Confer Protection against Staphylococcus aureus Infection, BMC Infectious Diseases. 2018, 18: 195.

ZHANG B., Cai J., Yu B., Xiong L., Lin Q., Yang X., XU C., Zheng S., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases. 2017, 216: 245-253.

Researcher : Yu C

Project Title:	Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2015

Project Title:	The mechanism of Cdc42 regulation in podosome assembly
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016
Completion Date:	04/2018

Project Title:	Induction of cancer cell apoptosis by integrin endocytosis
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	05/2017
Completion Date:	02/2019

Project Title:	Investigating the functional role of spatial-temporal activation of myosin-II in invadopodia disassembly
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Investigating the functional role of myosin-1e in cytoskeletal regulations, podosome formations, and matrix organizations
Investigator(s):	Yu C, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	A study of lipid-mediated adhesion transformation by chemical and photo-activable approaches
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Gordon Research Conference: Biointerface Science; Endocytic mechanism of podosome at the cell-matrix interface
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

Chen Z., Oh D., Biswas K., Yu C., Zaldel-Bar R. and Groves J., Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility, Proceedings of the National Academy of Sciences. 2018, 201719961.

Yu C., Force-dependent integrin endocytosis at the podosome, The 3nd International Symposium on Mechanobiology, National University of Singapore. 2017.

Yu C., Force-dependent signal transduction at integrin-mediated adhesions , 2017 Meeting of Biophysical Society of Hong Kong. 2017.

Yu C., Functional role of Myosin-1e in phosphatidylinositol signaling and podosome assembly, 3D Lab Exchange Symposium: Interaction of Nano-Biotechnology, Chemical and Medical Biology and Informatics, Bonn University, Germany. 2018.

Yu C., Matrix microenvironment orchestrates force-dependent integrin signaling , Departmental seminar, Department of Biomedical Engineering, PolyU. 2018.

Yu C., Matrix-force dependent integrin signaling and receptor endocytosis at the podosome, Max Planck–Croucher Symposium 2018: The Future of Biology . 2018.

Researcher : Yu Z

List of Research Outputs

YU Z., Hnrnpa1 Mutation Cause Congenital Heart Defects (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Yuen KS

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Yuen K.Y. and Jin D., Zika virus NS5 protein selectively activates type II interferon signaling in human glioblastoma cells., Cell Symposium on “Neuro-Immune Axis: Reciprocal regulation in development, health, and disease, Sitges, Spain, September 17-19, 2017.. 2017.

Jia L.J., Yip Y.L., Lin W., Yuen K.S., Jin D. and Tsao G.S.W., Regulation of lytic Epstein-Barr virus replication in a newly established nasopharyngeal cancer cell line, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

Wang F., Fung S.Y., Gao W., Deng J., Cheng Y., Chaudhary V., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing, Nucleic Acids Research. 2018.

Researcher : ZHANG H

List of Research Outputs

WANG L., ZHANG H. and Sham M.H., Unravelling a Eya1-Notch axis in epibranchial placode differentiation during craniofacial morphogenesis, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

ZHANG H., WANG L., Wong Y.M.E., Tsang S.L., Xu P.X., Lendahl U. and Sham M.H., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis, eLife. 2017, 6: e30126.

Researcher : ZHANG J

List of Research Outputs

TANG W.C., Tsang C.M., ZHANG J., You C., Jones G.E. and Tsao G.S.W., M2-polarized macrophages induced invadopodia formation in EBV-associated nasopharyngeal carcinoma through TNFα signalling and LMP1 induction, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., Tsang C.M. and Tsao G.S.W., EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma, Advances in Experimental Medicine and Biology. Springer, 2017, 1018.

ZHANG J., Lin W., Tsang C.M., LIU T., TANG W.C., Yip Y.L., Deng W., Jia L.J. and Tsao G.S.W., Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling to reprogram glucose metabolism and enhance cell motility in nasopharyngeal epithelial cell, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

ZHANG J., Jia L.J., LIU T., Yip Y.L., TANG W.C., Lin W. and Tsao G.S.W., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a-mediated histone acetylation in nasopharyngeal cells, Gordon Research Conference: Nasopharyngeal Carcinoma 2018.

ZHANG J., Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1α-mediated histone acetylation in nasopharyngeal epithelial cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : ZHANG Y

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

ZHANG Y., Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events, Matrix Biology. 2018.

Zhang Y., XIONG C., Kudelko M.A., LI Y., Wang C., Wong Y.L., Tam V., Rai M.F., Cheverud J., Lawson H.A., Sandell L., Chan W.C.W., Cheah K.S.E., Sham P.C. and Chan D., Early onset disc degeneration in SM/J mice is associated with ion transport systems and fibrotic changes., Matrix Biol. 2018.

Researcher : ZHANG Y

List of Research Outputs

ZHANG Y., Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events, Matrix Biology. 2018.

Researcher : ZHANG Z

List of Research Outputs

Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3.

Researcher : ZHAO J

List of Research Outputs

ZHAO J., The specific role of different Kinesin I motor proteins on synapse development in neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : ZHOU N

List of Research Outputs

ZHOU N., Self-organizing pattern formation of synthetic multicellular systems (PhD Thesis), The University of Hong Kong. 2018.

Researcher : ZHU S

List of Research Outputs

ZHU S., Exploring bacterial killing mechanisms on the apical surface of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2018.

Researcher : ZHU Y

List of Research Outputs

Liu J., Lv L., Gong J., Tan Y., ZHU Y., Dai Y., Pan X., Huen M.S.Y., Li B., Tsao G.S.W., Huo J. and Cheung A., Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma, International Journal of Cancer. 2017.

Zhu Y., Li B., Xu W.W., Lam A.K.Y., Law S.Y.K. and Cheung A., Serglycin promotes migration and invasion of esophageal cancer cells, Proceedings of the Annual Meeting of the American Association for Cancer Research. 2018, 59: 811.

Researcher : Zhang Y

List of Research Outputs

ZHANG Y., Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events, Matrix Biology. 2018.

Researcher : Zhou L

Project Title:	Establishment and applications of organoid cultures from primary hepatic carcinomas - a pilot study
Investigator(s):	Zhou L, Ma SKY, Yan HHN, Man K, Lo CM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	04/2017
Completion Date:	02/2019

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

LI T.W., Zhou L., Lee T. and Ma S.K.Y., Myofibroblast secreted follistatin-like 1 (FSTL1) promotes metastasis and stemness of hepatocellular carcinoma (HCC), 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Tong M., CHE N., Zhou L., LUK T.C.S., Lui Kau W.F., Chai S., Ngan E.S.W., Lo C.M., Man K., Ding J., Lee T.K. and Ma S.K.Y., Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib, Journal of Hepatology. 2018, 69(4): 826-839.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Zhou L., ISSCR Travel Award 2018, ISSCR Zhongmei Chen Yong Travel Awards for Scientific Excellence. 2018.

Researcher : Zhou Y

List of Research Outputs

LI X., Mak C.Y., Zhou Y., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., PIK3R1 loss activates AKT and STAT3 signaling in ovarian cancer, American Association of Cancer Research Annual Meeting 2018.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012
Completion Date:	08/2017

Project Title:	MT1-MMP-mediated ADAM15 shedding in angiogenesis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2013

Project Title:	MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling
Investigator(s):	Zhou Z, Osorio Da Silva LA
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2014

Project Title:	Regulation of heterochromatin remodeling in DNA repair and aging
Investigator(s):	Zhou Z, Hao Q, Chu IK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	02/2014

Project Title:	Outstanding Researcher Award 2013-14
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2014

Project Title:	Lamin A in Chromatin Dynamics and Aging
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2016

Project Title:	SIRT6 in bone marrow stromal cell potency and the development of osteoporosis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	SIRT6 deacetylates p53 to modulate cellular senescence and aging
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	UHRF1 in KLF4 ubiquitination and skin dysplasia
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	Frontiers in Aging and Longevity
Investigator(s):	Zhou Z, Hao Q, Kwan JSK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	05/2018

List of Research Outputs

GHOSH S., WONG S.K.K., JIANG Z., Liu B., Wang Y., Hao Q., Gorbunova V., LIU X. and Zhou Z., Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice, eLife. 2018, 7.

LI T., WANG L., DU Y., Xie S., YANG X., Lian F., Zhou Z. and Qian C., Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research. 2018, 46: 3218-3231.

Zhou Z., Editor in Chief, Translational Medicine of Aging. Beijing, KeAi, 2017.

Zhou Z., MT1-MMP in Lymphangiogenesis., Gordon Research Conference, July 9-14, 2017, USA. 2017.

Zhou Z., The role for MT1-MMP in neurogenesis and hydrocephalus, International Symposium of Genomics and Regenerative Medicine, Aug 28-Sep 1, 2017 Hong Kong. 2017.

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