DEPT OF OBSTETRICS & GYNAECOLOGY
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Researcher
: Chan A |
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List of Research Outputs |
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Chan A., Choy M.Y. and Lao T.T.H., Gestational diabetes mellitus is associated with decreased IL-6 level following treatment, American Journal of Reproductive Immunology. 2007, 57: 339. |
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Chan A., Choy M.Y. and Lao T.T.H., Maternal IP-10 and RANTES levels in treated Gestational Diabetes Mellitus, American Journal of Reproductive Immunology. 2007, 57: 339. |
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Researcher
: Chan CCW |
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List of Research Outputs |
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Chan C.C.W. and Ho P.C., Polycystic ovary syndrome in Asian women, In: Gabor Kovacs and Robert Norman, Polycystic Ovary Syndrome. United Kingdom, Cambridge University Press, 2007, Second edtion: 316-330. |
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Chan C.C.W., Ng E.H.Y., Tang F.O.S., Lee C.P. and Ho P.C., The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus, Gynecological Endocrinology. 2006, 22(9): 516-520. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized comparison of side effects and patient convenience between CyclogestÒ suppositories and EndometrinÒ tablets used for luteal phase support in IVF treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 131: 182-188. |
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Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26: 931-939. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with live birth following assisted reproduction treatment than in those who suffer a miscarriage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage, Human Reproduction. 2007, 22(4): 1134-1141. |
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Researcher
: Chan CP |
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List of Research Outputs |
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Chan C.P., Prenatal diagnosis of body stalk anomaly at 11 weeks gestation - confirmation by hysterofetoscopy, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P. and Tang M.H.Y., Cystic hygroma detected in the first trimester scan, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P., Wong S.F., Tse H.Y. and Tang M.H.Y., Effect of first trimester ultrasound screening on perinatal outcome, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
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Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
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Researcher
: Chan DW |
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Project Title: |
Characterization of the roles of Dual specificity MAPK phosphatase 3 (MKP-3) in ovarian cancer |
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Investigator(s): |
Chan DW, Ngan HYS |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2006 |
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Abstract: |
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Ovarian cancer is one of the leading
causes of death in women. Although there have been advances in the treatment
of ovarian cancer, the associated mortality rate of this cancer has not
improved significantly over the past decade. Therefore, understanding the
molecular mechanisms in the development of ovarian cancer through
identification and characterization of oncogenes and tumor suppressor genes
will help discovery of novel targets for therapies. To achieve this, we have
previously done cDNA microarray analysis on ovarian cancer cell lines and
immortalized human normal surface epithelial cell lines (HOSEs). We found
that a gene called Dual specificity MAPK phophatase 3 (MKP-3/DUSP6) was
downregulated in ovarian cancer cells. Many studies have documented that
MKP-3 possesses anti-tumorigenic effect on pancreatic cancer through
inactivation of ERK activity (Furukawa et al., 1998; Furukawa et al., 2003).
The finding of underexpression of MKP |
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List of Research Outputs |
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Chan
D.W., Liu
V.W.S. and Ngan H.Y.S., Loss of
MKP3 is associated with cisplatin-resistance and tumorigenicity of ovarian
cancer, Hong Kong International Cancer Congress, |
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Chan
D.W., Liu
V.W.S., Furukawa T., Tsao G.S.W.,
Yao K.M., Chan K.K.L. and Ngan H.Y.S., Loss of MKP3 is associated
with cisplatin-resistance and tumorigenicity of ovarian cancer, American
Association for Cancer Research. Annual Meeting 2007. |
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Lee
Y.W., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the
role of AMPK-γ |
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Liu
V.W.S., Chan D.W. and Ngan H.Y.S., High frequency of promoter
hypermethylation of metallothionein 1E in endometrial carcinomas, American
Association for Cancer Research. Annual Meeting 2007 |
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To
M.Y., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the
role of FOXG1B in the development of ovarian cancer, The 11th Research
Postgraduate Symposium 2006, The |
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Researcher
: Chan KKL |
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Project Title: |
Relationship between placental ratio and placental function |
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Investigator(s): |
Chan KKL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Seed Funding for New Staff |
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Start Date: |
01/2003 |
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Abstract: |
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To examine the relationship between PR and placental function in terms of fetal acid- base balance, haematology and biochemiatry; to determine if there is a cut-off in the PR for the detection of fetal growth restriction (FRG) as reflected by changes in placental function in newborns with birthweigth within the normal range. |
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Project Title: |
The role resistin in gestational diabetes and its relationship with pregnancy outcome |
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Investigator(s): |
Chan KKL, Lam KSL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
02/2004 |
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Abstract: |
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To investigate the hypothesis that resistin expression is associated with insulin resistance in pregnancy and has implications on neonatal outcome. |
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Project Title: |
Iron supplement in pregnancy and development of gestational diabetes - a randomized placebo-controlled trial |
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Investigator(s): |
Chan KKL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To conduct a randomized placebo control trial to establish the relationship between iron store and development of GDM; to explore the mechanism by which a high iron load is related to GDM; to explore the relationship between iron store and liver production of insulin resistance; to explore the relationship between iron store and liver production of IGF which has similar action as insulin on glucose metabolism, whose level has been associated with development of disbetes. |
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Project Title: |
Oestrogen receptor subtypes status in ovarian cancer |
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Investigator(s): |
Chan KKL, Tam KF, Ngan HYS, |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
01/2006 |
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Abstract: |
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Objective : To investigate the
relationship between oestrogen receptors subtypes and clinical parameters in
ovarian cancer Key issues and problem addressed: Ovarian cancer cells, like
breast cancer cells, express oestrogen receptors (Rao 1991) and are oestrogen
sensitive. Oestrogen is a steroid hormone, mainly synthesised in the ovary
but also in peripheral tissues through aromatization of androgen ( |
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Project Title: |
To investigate the relationship between oestrogen receptor subtype status and the effects of oestrogen agonists, antagonists and selective oestrogen receptor modulators ( SERM) on ovarian tumour cell growth |
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Investigator(s): |
Chan KKL, Tam KF, Ngan HYS |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
01/2007 |
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Abstract: |
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Oestrogen regulates the expression of
many genes that are important for cell proliferation, inhibition of
apoptosis, stimulation of invasion and metastasis and promotion of
angiogenesis. Most of the effects of oestrogen are medicated by oestrogen
receptors (ER). ER has at least 2 functions. Apart from being a transcription
factor for oestrogen related genes, it also functions outside the nucleus and
in the plasma membrane to active growth factor signalling. Ovarian cancer
cells express oestrogen receptors and are oestrogen sensitive. Therefore,
oestrogen can potentially affect ovarian cancer cell growth. Hormonal therapy
is an attractive option in the treatment of ovarian cancer because of its
better side effect profile compared to standard chemotherapy regimes.
Tamoxifen, a partial oestrogen agonist which is widely used in the treatment
of breast cancer has also been used in the treatment of ovarian cancer.
However, overall response rate is only about 13% (Perez-Gracia JL et al).
Most of the studies on the use of tamoxifen in ovarian cancer did not fully
investigate the response with respect to the receptor status of their
subjects. Furthermore, a new oestrogen receptor, the ER-β, was discovered
after most of these earlier studies and a number of new selective oestrogen
receptors modulators and pure antagonists have been developed. Second and
third generation SERMs such as raloxifene and arzoxifene had been developed
to produce favourable oestrogen activities , for example, prevention of
osteoporosis ,while minimizing the less desirable effects such as increasing
breast cancer risk. Fulvestrant , a pure oestrogen antagonist, was developed
and already licensed for use in treatment for advanced breast cancer. Again,
the use of these newer agents in ovarian cancer is much less investigated.
While a no. of studies have looked at the effects of oestrogen and tamoxifen
on the ovarian cancer cell growth in vitro and suggested that oestrogen might
stimulate cell proliferation while tamoxifen might inhibit cell growth
(Langdon , Lindgren , Taube ), there is minimal information on the effect of
the newer agents. Moreover, the role of oestrogen receptors on these observed
effects of oestrogen or tamoxifen on ovarian cancer cell growth was not
clear. Although the antiproliferative effect of tamoxifen observed was
related to the cytosolic ER content in 18 ovarian tumours (Lazo), no
significant differences in ER expression was found between the higher and
lower survival groups when cells were cultured in 17 β- oestradiol (Taube ).
These previous studies had not taken into account of the receptor subtypes
status. In the presence of different receptor subtypes, both oestrogen and
tamoxifen may have different actions. In the presence of ER α, both
oestradiol and tamoxifen have agonist action, but in the presence of ER β,
oestrogen blocks the agonist effect of tamoxifen and tamoxifen would give be
a pure antagonistic action ( Barkhem, Hall, Paech, Katzenellenbogen). The
differences in action in the presence of different receptor subtypes may lead
to the discrepancies observed in previous reports. We therefore propose to
study the effects of oestradiol ( the agonist ), different SERMS as well as
the pure antagonist on ovarian cell lines with respect to receptors subtypes
status. References Perez-Gracia JL. Carrasco EM. Tamoxifen therapy for
ovarian cancer in the adjuvant and advanced settings: systematic review of
the literature and implications for future research. Gynecol Oncol. 2002;
84:201-9 Langdon SP. Hawkes MM. Lawrie SS et al. Oestrogen receptor
expression and the effects of oestrogen and tamoxifen on the growth of human
ovarian carcinoma cell lines. Br J Cancer. 1990; 62:213-6 Lindgren P.
Backstrom T. Mahlck CG. et al. Steroid receptors and hormones in relation to
cell proliferation and apoptosis in poorly differentiated epithelial ovarian
tumors. Int J Oncol 2001 ;19:31-8 Taube M. Hockenstrom T. Isaksson M. et al
Effects of sex steroids on survival and receptor expression in ovarian
epithelial tumour cells. Int J Oncol. 2003 ;22:1257-62 Lazo JS. |
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List of Research Outputs |
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Chan
D.W., Liu V.W.S., Furukawa T., Tsao G.S.W., Yao K.M., Chan K.K.L. and Ngan H.Y.S., Loss of MKP3 is associated
with cisplatin-resistance and tumorigenicity of ovarian cancer, American
Association for Cancer Research. Annual Meeting 2007. |
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Chan K.K.L., Huang F.Y., Tam K.F., Tse K.Y. and Ngan H.Y.S., Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia, American Journal of Gynecology and Obstetrics. 2006, 195: 1282-1286. |
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Chan K.K.L., Tam K.F. and Ngan H.Y.S., The use of vaginal anti-microbial after large loop excision of transformation zone (LLETZ) - a prospective randomized trial, 11th Biennial Meeting International Gynaecologic Cancer Society, Santa Monica, USA, 14-18 October. 2006. |
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Lao T.T.H. and Chan K.K.L., Maternal third trimester ferritin level and subsequent labour, American Journal of Reproductive Immunology. 2007, 57: 337. |
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Ngan H.Y.S., Tam K.F., Lam K.W. and Chan K.K.L., Relapsed gestational trophoblastic neoplasia: A 20-year experience, Journal of Reproductive Medicine. 2006, 51(10): 829-834. |
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Tam K.F., Lam K.W., Chan K.K.L. and Ngan H.Y.S., Detection of pelvic lymphocysts following bilateral pelvic lymphadenectomy using 3-D ultrasonogram, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., 20-year experience of managing profuse bleeding in gestational trophoblastic disease, Journal of Reproductive Medicine. 2007, 52(5): 397-401. |
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Project Title: |
The signaling pathways of L-SIGN in response to ligand binding |
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Investigator(s): |
Chan YK, Khoo |
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Department: |
Pathology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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L-SIGN (liver/lymph node-specific ICAM-3
grabbing non-integrin) serves as a receptor for many of viral pathogens,
including HIV1;2, HCV3, Ebola virus4, and SARS coronavirus (SARS-CoV)5. Its
homologue, DC-SIGN, also serves as a receptor for many of the same viruses
and has been utilized by some of the pathogens to escape immuno-surveillance.
The binding sites of L-SIGN and DC-SIGN appear evolved to serve different
functions. DC-SIGN mediates trafficking as a recycling receptor, releasing
ligand at endosomal pH. In contrast, L-SIGN does not release ligands at
endosomal pH nor does it mediate endocytosis, which indicates that it only
functions as a binding receptor6. L-SIGN on transfected cells has been shown
to internalize HCV virus-like particles and traffic to either lysosomal or
non-lysosomal compartment depending on the cell type7. We speculate that
L-SIGN may have other un-explored functions and signaling events after L-SIGN
engagement with its ligand. Mitogen-activated protein kinases (MAPKs) are
signal transducers that respond to extracellular stimulations, such as
cytokines and viral infection. They in turn regulate cell differentiation,
proliferation, survival and apoptosis8-11. There are three distinct MAPK
cascades, extracellular signal-regulated kinases (ERK1/2), c-JUN N-terminal
kinases (JNK), and p38/MAPK. Phosphatidylinositol 3-kinase (PI3K) signaling
pathway also plays an important role in various cellular processes including
cell growth and survival, vesicular trafficking, etc12. One of the key
signaling molecules in the pathway is AKT which phosphorylates targets
including GSK-3, FKHR-L1 and BAD. SARS-CoV infected permissive Vero E6 cells
(which express the SARS-CoV receptor, ACE213) has been demonstrated to
activate the MAPK and PI3K/Atk signaling pathways14-16. p38/MAPK has been
shown to be activated during SARS-CoV viral replication |
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List of Research Outputs |
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Researcher
: Chen M |
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List of Research Outputs |
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Chen M., Lee C.P., Lam Y.H., Chan S.M. and Tang M.H.Y., Chinese fetal renal pelvis measurements at 12-14 weeks of gestation, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, 25-28 February, 2007. |
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Chen M., Comparison between university hospital and district hospitals for first trimester ultrasound screening for fetal structural abnormalities, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P. and Tang M.H.Y., Cystic hygroma detected in the first trimester scan, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P., Wong S.F., Tse H.Y. and Tang M.H.Y., Effect of first trimester ultrasound screening on perinatal outcome, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., First trimester fetal biometry in Chinese population, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. 2007. |
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Chen M., Lee C.P., Tang R., Chan B., Ou C.Q. and Tang M.H.Y., First-trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2006, 26(8): 703-706. |
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Chen M., Lee C.P., Lam Y.H., Ou C. and Tang M.H.Y., First-trimester fetal limb biometry in Chinese population, Prenatal Diagnosis. 2007, 27: 133-138. |
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Chen M., Lee C.P. and Tang M.H.Y., First-trimester fetal limb biometry in the Chinese population, In: Comments by Dr. Mahmut Tuncay Ozgun for Article (Chen et al., Prenatal Diagnosis 2007; 27:133-138) , Prenatal Diagnosis. 2007, 27: 587. |
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Chen M., Lam Y.H., Ma E.S.K., Wong K.Y. and Tang M.H.Y., Intrauterine therapy in a fetus with severe congenital dyserythropoietic anaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
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Leung K.Y., Liao C., Ma S.Y., Chen M., Lee C.P., Lam Y.H. and Tang M.H.Y., 2D and 3D ultrasound prediction of homozygous a thalassemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Comparison of 2D and 3D multi-planar ultrasonography in the prediction of alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Use of 2D and 3D ultrasound to study the growth of fetuses affected by homozygous alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung W.C., Chen M., Lau E.T.K., Lao T.T.H. and Tang M.H.Y., Application of rapid aneuploidy detection versus karyotyping in prenatal diagnosis, 產前診斷中常見染色體異常的快速檢測與核型分析技術的應用, Chinese Journal of Obstetrics and Gynecology. (中華婦產科雜志), 2007, 42(5): 348-350. |
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Researcher
: Cheung TM |
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List of Research Outputs |
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Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Researcher
: Chiu CN |
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Project Title: |
Prevalence of
Y-chromosome AZFd microdeletion in |
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Investigator(s): |
Chiu CN, Ng EHY, Lee CKF, Yeung WSB |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2004 |
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Abstract: |
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To determine the prevalence of AZFd
deletion in a Chinese population in |
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List of Research Outputs |
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Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
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Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
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Seppala M., Koistinen H., Koistinen R., Chiu C.N. and Yeung W.S.B., Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations, Human Reproduction Update. 2007, 13: 275-287. |
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Wong S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Yeung
W.S.B., Chiu C.N. and Lee C.K.F., An update on
glycodelin-research-its implication in reproductive medicine. , The 1st
Chinese Society of Reproductive Medicine/Chinese Society of Reproductive
Biology Conjoint Annual Meeting. |
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Yeung
W.S.B., Chiu C.N., Lee C.K.F., Seppala M., Koistinen R. and
Koistinen H., Glycodelin as a modulator of sperm function, |
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Yeung W.S.B., Lee C.K.F., Koistinen R., Koistinen H., Seppala M., Ho P.C. and Chiu C.N., Glycodelin: a molecule with multi-functions on spermatozoa., Soc Reprod Fertil Suppl. 2007, 63: 143-51. |
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Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The identification of a zona pellucida binding protein in human spermatozoa., XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
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Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The regulation of sperm fertilizing capacity by glycodelin, XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
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Researcher
: Chow JFC |
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List of Research Outputs |
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Yeung W.S.B. and Chow J.F.C., New development in preimplantation genetic diagnosis, XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia.. 2006. |
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Researcher
: Chow WN |
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List of Research Outputs |
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Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Chow
W.N., Lee
C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
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Lee
C.Y.L., Tse P.K., Chow W.N., Lee C.K.F. and Yeung W.S.B., Hormonal regulation and
convertase activities of complement |
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Researcher
: Choy MY |
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Project Title: |
An investigation of human placental insulin degrading enzyme in normal and diabetic pregnancies |
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Investigator(s): |
Choy MY, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
10/2005 |
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Abstract: |
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Gestational diabetes mellitus (GDM)
affects 12% of pregnant women and is associated with perinatal complications
including macrosomia which is strongly associated with fetal death,
prematurity, birth trauma and respiratory distress syndrome. More
importantly, offspring of GDM have a higher risk of developing obesity,
impaired glucose tolerance, and type 2 diabetes mellitus (DM2).1 As the
interface between mother and fetus, the placenta is the obligatory target of
adverse environmental changes in diabetic pregnancies. Although it is
generally accepted that the hyperinsulinemia in DM2 is a compensatory
response to insulin resistance of target tissues, there is increasing
evidence that, at least in some populations, basal hyperinsulinemia itself
can have a primary role in the pathogenesis of DM2. Insulin resistance has
been reported to occur as a result of excessive insulin degradation.2 IDE
(insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that
has been shown to regulate both cerebral amyloid beta-peptide and plasma
insulin levels in vivo. In vitro, IDE not only degrades insulin and glucagon,
but also insulin growth factors I and II, the leader peptide of peroxysomal
prethiolase ,transforming growth factor , the ß-amyloid peptide, and other
peptides. |
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List of Research Outputs |
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Chan A., Choy M.Y. and Lao T.T.H., Gestational diabetes mellitus is associated with decreased IL-6 level following treatment, American Journal of Reproductive Immunology. 2007, 57: 339. |
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Chan A., Choy M.Y. and Lao T.T.H., Maternal IP-10 and RANTES levels in treated Gestational Diabetes Mellitus, American Journal of Reproductive Immunology. 2007, 57: 339. |
|
Shek N.W.M., Choy M.Y. and Lao T.T.H., Tumour necrosis factor alpha induced insulin resistance in a human first trimester trophoblast cell line , American Journal of Reproductive Immunology. 2007, 57: 325. |
|
Researcher
: Chung MK |
|
List of Research Outputs |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
|
Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
|
Researcher
: Fan SYS |
|
List of Research Outputs |
|
Cheung C., Chan E.K.L. and Fan S.Y.S., Post-abortion psychological adjustment of Hong Kong youths, the 5th International Conference on Social Work in Health and Mental Health, Hong Kong SAR, China. 2006. |
|
Researcher
: Ho PC |
|
Project Title: |
Role of glycodelin in fertilization |
|
Investigator(s): |
Ho PC, Lee CKF, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
To establish a 3D capillary cumulus cell-matrix model to study the effect of the cumulus cell mass on the spermatozoa passing through it; to study the effect of GdA and GdF on the quality of spermatozoa passing through the cumulus mass; to study the metabolism of GdA and Gdf in cumulus cells; and to study the production of GdA and GdF by the granulosa cells, endometrial cells and oviducal cells. |
|
Project Title: |
Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium |
|
Investigator(s): |
Ho PC, Ngan ESW, Ng EHY, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To examine the temporal and spatial expression pattern of EG-VEGF and its receptors in human endometrium; to elucidate the mitogenic and angiogenic properties of EG-VEGF in human endometrial microvascular endothelial cell (hEMVEC); to study the expression of EG-VEGF in patients with endometriosis. |
|
Project Title: |
Will letrozole improve the ovarian response in women with poor ovarian reserve who are undergoing IVF treatment? |
|
Investigator(s): |
Ho PC, Tang OS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
07/2005 |
|
Abstract: |
|
Letrozole is a non-steroidal reversible, competitive aromatase inhibitor that is highly potent and selective. It has a short half-life of around 45 hours (Sioufi et al., 1997). The rapid elimination from the body and the absence of estrogen receptor down-regulation effect as observed in clomiphene citrate treatment allow adequate time for the endometrium to regenerate from the anti-estrogen effect of the drug and therefore enhances implantation. The mechanism of action of letrozole in ovulation induction is proposed to be due to the selective inhibition of the aromatase enzyme that catalyzes the rate-limiting step in the conversion of androstenedione and testosterone to estrone and estradiol respectively. Treatment with an aromatase inhibitor in the early part of the menstrual cycle will decrease estrogen synthesis and hence the negative feedback centrally, resulting in increased gonadotrophin secretion. Moreover, by blocking the conversion of androgens to estrogens in the ovary, the accumulating intra-ovarian androgens may increase follicular sensitivity through amplification of FSH receptor gene expression (Weil et al., 1998; 1999; Vendola et al., 1998; 1999). |
|
Project Title: |
Role of olfactomedin in implantation |
|
Investigator(s): |
Ho PC, Lee CKF, Ng EHY, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To study the expression of olfactomedin in different phases of the reproductive cycle; to determine the site of olfactomedin biosynthesis; to study the role of steroid in the regulation of olfactomedin biosynthesis; to study the role of the molecule in embryo adhesion and trophoblast invasion. |
|
Project Title: |
A pilot study on the use of letrozole and misoprostol for the termination of second trimester pregnancy |
|
Investigator(s): |
Ho PC, Tang FOS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
Objectives: Misoprostol with or without
mifepristone has been used for medical abortion in the second trimester.
Pre-treatment with mifepristone resulted in a shorter induction-to-abortion
interval as compared with regimens without mifepristone (El-Rafaey et al,
1995; Ho et al, 1996; Wong et al, 2000; Ashok et al, 1999). Studies carried
out in early 1980s demonstrate that the efficacy of mifepristone alone in
inducing complete abortion in the first trimester is at most 60-80% in the
human. Dr Garfield R et al. have demonstrated recently that certain compounds
in combination with an antiprogestin can significantly improve abortifacient
efficacy. For example, when low doses of mifepristone (which alone have no
effect on pregnancy) have been combined with low doses iNOS inhibitors or
aromatase inhibitors or progesterone synthesis inhibitors, which again alone
have no effect, a tremendous synergistic effect has been seen in the mouse,
the rat and the guinea pig.(Garfield, unpublished) Abortion rates have been
up to 100%, there has been a complete evacuation of the uterus soon after the
treatment and the duration of bleeding has been surprisingly short. Letrozol
is an aromatase inhibitor used to treat estrogen-dependent breast cancer. It
is a third generation aromatase inhibitor. Aromatase, an enzyme of cytochorme
P450 superfamily and the product of CY195 gene, is highly expressed in the
placenta and granulosa cells of ovarian origin. Aromatase is also present in
several non-glandular tissue including subcutaneous fat, liver, muscle,
brain, normal breast, and breast-cancer tissue. Residual estrogen production
after menopause is solely from nonglandular sources (Miller et al, 1982 &
Nelson et al, 2001). In premenopausal women, the use of aromatase inhibitors
leads to an increase in gonadotropin secretion because of the reduced
feedback of estrogen to the hypothalamus and pituitary. The short-term
application of letrozole has recently been successful for the induction of
ovulation in women with infertility and dosage up to 7.5mg has been used
(Mitwally et al, 2002. Al-Fozan et al., 2004). Third generation aromatase
inhibitors have specific action at clinical doses and they have no effect on
basal levels of cortisol and aldosterone (Plourde et al, 1995; Bajetta et al,
2000 & Bisagni et al, 1996). Estrogen and progesterone are important
hormones for pregnancy. The use of aromatase inhibitor may cause a decrease
in estrogen production by the corpus luteum and the placenta and thus results
in abortion. The use of letrozole may potentiate the effect of prostaglandin
and thus, can shorten the induction to abortion interval and increase the
success rate. We are proposing a pilot study to investigate the effect of the
combination of letrozole and misoprostol in the termination of second
trimester pregnancy: a single dose of 7.5mg letrozol on Day 1 and Day 2
followed by repeated doses of 0.4 mg misoprostol from Day 3. The objective of
the present pilot study is to test whether the aromatase inhibitor,
letrozole, have a synergistic effect when used with misoprostol for the
termination of second trimester pregnancy in women at 12 to 20 weeks of
gestation. This treatment regimen will be studied and the following outcomes
will be assessed: (i) their capability of inducing abortion (ii) the
induction-to-abortion interval; and (iii) the frequency of side effects
Reference: 1. Al-Fozan H, Al-Khadouri M , Tan ST, Tulandi T. A randomized
trial of letrozole versus clomiphene citrate in women undergoing
superovulation. Fert. Steril. 2004, 84, 1561-3. 2. Ashok PW & Templeton
A. (1999) Nonsurgical mid-trimester termination of pregnancy: a review of 500
consecutive cases. Br J Obstet Gynaecol., 106, 706-10. 3. Bajetta E, Zilembo
N, Bischisao E, et al. (2000) Tumour response and estrogen suppression in
breast cancer patients treated with aromatase inhibitors. Ann Onco., 11,
1017-22. 4. Bisagni G, Cocconi G, Scaglione F, Fasichini F, Pfister C, Trunet
PF. Letrozole, a new oral non-steroidal aromatase inhibitor in treating
postmenopausal patients with advanced breast cancer: a pilot study. (1996)
Ann onco., 7, 99-102. 5. El-Rafaey H and Templeton A. (1995) Induction of
abortion in the second trimester by a combination of misoprostol and
mifepristone: a randomized comparison between two misoprostol regimens. Hum.
Reprod., 10, 475-8. 6. Ho PC, Chan YF, Lau W. (1996) Misoprostol is as
effective as gemeprost in termination of second trimester pregnancy when
combined with mifepristone: a randomized comparative trial. Contraception,
53, 281-3. 7. Miller WR, Hawkins RA, Forrest AP. (1982) Significance of
aromatase inhibitors in human breast cancer. Cancer Res., 42 suppl,
3365s-3368s. 8. Nelson LR, Bulun SE. Estrogen production and action. (2001) J
Am Acad Dermatol., 45 suppl: S116-S124. 9. Mitwally MF, Casper RF. (2002)
Aromatase inhibitor for ovarian stimulation: future avenue for infertility
management. Curr Opin Obstet Gynecol., 14, 255-63. 10 Plourde PV, Dyroff M,
Dowsett M. Demers L, Yates R, Webster A. (1995) ARIMIDEX: a new oral,
once-a-day aromatase inhibitor. J Steroid Biochem Mol Biol., 53, 175-9. 11. |
|
Project Title: |
Adrenomedullin and sperm functions |
|
Investigator(s): |
Ho PC, Yeung WSB, Chiu CN, Lee CKF, Tang F |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To determine the effect of adrenomedullin on sperm functions; to study the effect of adrenomedullin on the spermatozoa from patients with mild fertilization problem; to investigate the signaling pathways of adrenomedullin in spermatozoa. |
|
List of Research Outputs |
|
Chan C.C.W. and Ho P.C., Polycystic ovary syndrome in Asian women, In: Gabor Kovacs and Robert Norman, Polycystic Ovary Syndrome. United Kingdom, Cambridge University Press, 2007, Second edtion: 316-330. |
|
Chan C.C.W., Ng E.H.Y., Tang F.O.S., Lee C.P. and Ho P.C., The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus, Gynecological Endocrinology. 2006, 22(9): 516-520. |
|
Chan E.K.L., Tiwari A.F.Y., Fong D.Y.T., Leung W.C., Brownridge D.A. and Ho P.C., Correlates of in-law conflict with intimate partner violence against pregnant women, Journal of Interpersonal Violence, 2007, (forthcoming). 2007. |
|
Chan V.N.Y., Ng E.H.Y., Yam I.Y.L., Yeung W.S.B., Ho P.C. and Chan T.K., Experience in preimplantation genetic diagnosis for exclusion of homozygous ao thalassaemia, Prenatal Diagnosis. 2006, 26: 1029-1036. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
|
Ho P.C., Associate Editor, Human Reproduction. 2006. |
|
Ho P.C., Director of Editorial Board in Obstetrics and Gynaecology, Journal of Paediatrics, Obstetrics and Gynaecology, 1997 till now. 2006. |
|
Ho P.C., Fertility regulation: New developments in delivery and dosages, In: TF Kruger, Z Van Der Spuy, RD Kempers, Book Chapter in "Advances In Fertility Studies and Reproductive Medicine - IFFS 2007". Juta & Co. Ltd, 2007, 1(1st published 2007): 267-271. |
|
Ho P.C., Fertility regulation: new developments in delivery and dosages, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ho P.C., In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007. |
|
Ho P.C., Management of repeated IVF failures associated with hydrosalpinx, As Invited Speaker to attend the 2006 Reproductive Medicine National Continuing Education Symposium, December 15-18, 2006, Shenzhen, P.R. China.. 2006. |
|
Ho P.C., Member of Editorial Board, Chinese Journal of Obstetrics and Gynaecology. 2006. |
|
Ho P.C., Member of Editorial Board, Clinical Obstetrics and Gynaecology (Bailliere Tindall). 2006. |
|
Ho P.C., Member of Editorial Board, Journal of Assisted Reproduction and Genetics. 2006. |
|
Ho P.C., Member of Editorial Board, Journal of Practical Obstetrics and Gynaecology. 2006. |
|
Ho
P.C., Member of Editorial Board, Journal
of Reproductive Medicine ( |
|
Ho
P.C., Use of ultrasound in assisted
reproduction, The 1st CSRM/CSRB Conjoint Annual Meeting, April 6-9, 2007, |
|
Ho P.C., Use of ultrasound in assisted reproduction, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. 2007. |
|
Ho P.C., Women's perceptions on medical abortion, Contraception. 2006, 74: 11-15. |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Kan A.S.Y., Caves N., Wong S.Y.W., Ng E.H.Y. and Ho P.C., A double-blind randomised controlled trial on the use of Entonox in pain relief during suction evacuation for the trimester pregnancy termination, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Kan A.S.Y., Caves N.D., Wong S.Y.W., Ng E.H.Y. and Ho P.C., A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination, Human Reproduction. 2006, 21(10): 2606-2611. |
|
Kan A.S.Y. and Ho P.C., Pain control in first-trimester suction evacuation, International Planned Parenthood Federation Medical Bulletin. 2006, 40(4): 4. |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., A transcriptomic approach
to understand endometrial responses to hormone stimulation in IVF patients. ,
Xian Symposium 2006 on Reproductive Medicine. Sep 16-17, Xian, |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity. , The 1st
CSRM/CSRB Conjoint Annual Meeting. |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity., The 1st
CSRM/CSRB Conjoint Annual Meeting. 7-9 April, |
|
Lee
C.K.F., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Expression of olfactomedin
(OLFM) isoforms in human endometrium. , Society for the Study of
Reproduction -39th Annual Meeting. Jul 29-Aug 1, |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Global gene expression
profiling and endometrial receptivity. , XVIII FIGO World Congress of
Gynecology and Obstetrics. |
|
Narvekar N., Glasier A., Dada K., Spuy Z.V.D., Ho P.C., Cheng L. and Baird D.T., Toward developing a once-a-month pill: a double-blind, randomized, controlled trial of the effect of three single doses of mifepristone given at midcycle on the pattern of menstrual bleeding, Fertility and Sterility. 2006, 86(4): 819-824. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized comparison of side effects and patient convenience between CyclogestÒ suppositories and EndometrinÒ tablets used for luteal phase support in IVF treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 131: 182-188. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ng E.H.Y. and Ho P.C., Ageing and ART: A waste of time and money?, Best Practice and Research Clinical Obstetrics and Gynaecology. 2007, 21(1): 5-20. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26: 931-939. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with live birth following assisted reproduction treatment than in those who suffer a miscarriage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage, Human Reproduction. 2007, 22(4): 1134-1141. |
|
Ng E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Management of male subfertility, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, Jan/Feb 2007: 37-43. |
|
Ng E.H.Y., Yeung W.S.B. and Ho P.C., Patients with three or less dominant follicles may not be associated with reduced pregnancy rate of in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2006, 129: 54-59. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Ngai C.S.W., Tang F.O.S. and Ho P.C., Drugs for second trimester termination of pregnancy, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 147-153. |
|
Tang F.O.S. and Ho P.C., Clinical applications of mifepristone , Gynecological Endocrinology. 2006, 22(12): 655-659. |
|
Tang F.O.S. and Ho P.C., Drugs used in first trimester termination of pregnancy, In: Edited by W.L.Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 141-146. |
|
Tang F.O.S. and Ho P.C., Mifepristone, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 131-133. |
|
Tang F.O.S. and Ho P.C., Pharmacology of prostaglandins, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 135-140. |
|
Tang F.O.S. and Ho P.C., The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion, Contraception. 2006, 74: 26-30. |
|
Tang F.O.S. and Ho P.C., The use of misoprostol for early pregnancy failure, Current Opinion in Obstetrics and Gynecology. 2006, 18: 581-586. |
|
Tiwari A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner violence: Comparing the Chinese Abuse Assessment Screen with the Revised Conflict Tactics Scales, BJOG, 2007, (forthcoming). 2007. |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The First Territory-wide
Survey on Intimate Partner Violence against Pregnant Women in Hong Kong, In:
organized by the University of Hong Kong, Hong Kong. November 24,, Presented
at the Conference on Violence in |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The first territory-wide
survey on intimate partner violence against pregnant women in |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The prevalence of intimate
partner violence among pregnant women in Hong Kong, International
Conference: Violence Against Women: Diversifying Social Responses. |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., Validation of a violence
screening tool as common language for health and social work professionals, 5th
International Conference on Social Work in Health and Mental Health. |
|
Wong S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Yeung W.S.B., Lee C.K.F., Koistinen R., Koistinen H., Seppala M., Ho P.C. and Chiu C.N., Glycodelin: a molecule with multi-functions on spermatozoa., Soc Reprod Fertil Suppl. 2007, 63: 143-51. |
|
Researcher
: Huang FY |
|
List of Research Outputs |
|
Chan K.K.L., Huang F.Y., Tam K.F., Tse K.Y. and Ngan H.Y.S., Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia, American Journal of Gynecology and Obstetrics. 2006, 195: 1282-1286. |
|
Researcher
: Hui PW |
|
List of Research Outputs |
|
Hui P.W., A few words of encouragement to MRCOG candidates, HKJOGM. 2006, 56. |
|
Hui P.W., Are babies from ART similar to babies from natural conception?, Weekly CME seminar, organized by Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, 14 June 2007, Hong Kong. 2007. |
|
Hui
P.W., Leung
K.Y., Lau E.T.K. and Tang M.H.Y., Confined placental
mosaicism of trisomy 16 presenting with placental mass and intrauterine
death, The 3rd International Scientific Meeting of the International
Society of Ultrasound in Obstetrics & Gynaecology. 25-28 February 2007, |
|
Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in fetu – from prenatal suspicion to postnatal confirmation. , The 3rd International Scientific Meeting of the International Society of Ultrasound in Obstetrics & Gynaecology, Hong Kong, 25-28 February 2007. |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Hui P.W., Pregnancy with Thrombocytopenia, Maternal Fetal Medicine Grand Round, Department of Obstetrics & Gynaecology, Queen Mary Hospital, The University of Hong Kong, 24 March 2007. 2007. |
|
Leung K.Y., Yin A., Hui P.W., Lee C.P. and Tang M.H.Y., Prenatal Screening for Down Syndrome, JPOG. 2007, 33: 80 - 87. |
|
List of Research Outputs |
|
Kan A.S.Y., Caves N., Wong S.Y.W., Ng E.H.Y. and Ho P.C., A double-blind randomised controlled trial on the use of Entonox in pain relief during suction evacuation for the trimester pregnancy termination, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Kan A.S.Y., A patient with uterine lipoleiomyoma, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Kan A.S.Y. and Ho P.C., Pain control in first-trimester suction evacuation, International Planned Parenthood Federation Medical Bulletin. 2006, 40(4): 4. |
|
List of Research Outputs |
|
Kwok K.Y., Tang M.H.Y., Law H.K.W., Ngai C.S.W., Lau Y.L. and Lau E.T., Maternal plasma or human serum albumin in wash buffer enhances enrichment and ex vivo expansion of human umbilical cord blood CD34+ cells, British Journal of Haematology. Blackwell, 2007, 137 (5): 468-474. |
|
Researcher
: Lam KW |
|
List of Research Outputs |
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Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
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Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Researcher
: Lao TTH |
|
Project Title: |
Dietary caloric intake and the development of gestational diabetes mellitus in at-risk Chinese women |
|
Investigator(s): |
Lao TTH, Leung WC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To determine the relationship between daily total caloric intake in the third trimester and the development of gestational diabetes mellitus in at-risk pregnant Chinese women; to compare the roles of toal caloric intake versus the carbohydrate: protein: fat ratio in the daily diet and development of gestational diabetes mellitus in the at-risk Chinese women. |
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Project Title: |
The role of adiponectin in the development of gestational diabetes mellitus and its effect on pregnancy outcome |
|
Investigator(s): |
Lao TTH, Lam KSL, Chan KKL |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To determine if plasma adiponectin concentration is reduced, at the time of the oral glucose tolerance test (OGTT), in women who develop GDM in the latter half of pregnancy versus women with normal OGTT; to determine, following the diagnosis of GDM, whether the subsequent changes in adiponectin concentration is associated with obstetric complications and perinatal morbidity; to correlate circulatory concentration of adiponectin with polymorphisms and mutations in the apM1 gene in high risk women with and without GDM, and with the expression of adiponectin in subcutaneous and omental fat cells obtained from biopsy at the time of caesarean delivery for obstetric indications; to correlate antenatal adiponectin concentration and result of the genetic study with the postnatal glucose tolerance status in the women who have developed GDM. |
|
Project Title: |
A study on the interrelationship among insulin-like growth factors, apoptosis and proliferation of trophoblast, and placental size throughout pregnancy, and their effects on infant outcome, in normal and diabetic pregnancies |
|
Investigator(s): |
Lao TTH, Cheung PT, Cheung ANY, Leung WC, Lam HSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To compare in the normal and diabetic pregnancies the relationship between ultrasound-estimated placenta size and its vasculature, and fetal size, with maternal circulatory levels of IGFs and IGFBPs in the three trimesters; to compare in the normal and diabetic pregnancies the relationship among placental expression of IGFs with placental apoptotic and proliferative indices and placental size at the time of delivery; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of obstetric and perinatal complications; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of fetal growth and size at birth; to examine the relationship between placental and newborn size with the placental expression of IGFs as well as the apoptotic and proliferative indices in normal and diabetic pregnancies. |
|
Project Title: |
Elevated TNF-α in gestational diabetes mellitus-cause or consequence? |
|
Investigator(s): |
Lao TTH, Leung WC, Ngai CSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To determine and compare the serial changes in maternal blood level of TNF-α and its receptors, C-reactive protein (CRP) , and ferritin in relation to the development of gestational diabetes mellitus (GDM) in Chinese pregnant women with singleton and twin pregnancies; to determine the relationship between changes in maternal blood level of TNF-α and its receptors, CRP and ferritin with the occurrence of complicantions in Chinese pregnant women with and with and without GDM, and whether there is any difference between singleton and twin pregnancies. To correlate the levels of TNF-α and its receptors between maternal blood with cord blood, and between these two compartments with placental size and the placental expression of TNF-α and its receptors. To correlate maternal and cord blood, and placental TNF-α and its receptors with the infant birthweight and development of perinatal complications, and the determine if there is any difference between singleton and twin pregnancies. |
|
Project Title: |
The relationship between the antioxidant defense system with the development of gestational diabetes mellitus and its complications in the Chinese population. |
|
Investigator(s): |
Lao TTH |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Gestational diabetes mellitus (GDM) has become the leading medical complication in pregnancy in the local Chinese population, and despite satisfactory glycaemic control, maternal and perinatal complications cannot be eliminated. One of the metabolic disturbances now documented with diabetes mellitus in non-pregnant subjects is an increased oxidative stress. The standard approach in the management of GDM is to normalize blood glucose level with dietary and insulin treatment, but this may not be sufficient to counter the increased oxidative stress, and the persistent risk of maternal and perinatal complications could be related to inadequate defense against the increased oxidative stress in GDM. There has been minimal information about the natural antioxidant defense systems, such as the enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and especially thioredoxin reductase (TRx), in pregnancy with and without GDM, and there is no information on these systems in the infant at the time of birth. These enzyme systems are present in the placenta and can also be measured in peripheral blood. The present study is designed to investigate (1) the maternal antioxidant defense systems at the time of diagnosis of GDM, comparing between women with normal and abnormal glucose tolerance; (2) and its subsequent changes in relation to treatment and glycaemic control, (3) the changes in relation to pregnancy complications in women with and without GDM; and (4) the changes in the fetal compartment as reflected in cord blood and placental tissue. |
|
List of Research Outputs |
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Chan A., Choy M.Y. and Lao T.T.H., Gestational diabetes mellitus is associated with decreased IL-6 level following treatment, American Journal of Reproductive Immunology. 2007, 57: 339. |
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Chan A., Choy M.Y. and Lao T.T.H., Maternal IP-10 and RANTES levels in treated Gestational Diabetes Mellitus, American Journal of Reproductive Immunology. 2007, 57: 339. |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Lao T.T.H., Effect of aging on obstetric outcome, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Lao
T.T.H., Epidemiology and risk factors for
gestational diabetes mellitus, XVIII FIGO World Congress of Gynecology and
Obstetrics, November 5-10, 2006, |
|
Lao T.T.H. and Chan K.K.L., Maternal third trimester ferritin level and subsequent labour, American Journal of Reproductive Immunology. 2007, 57: 337. |
|
Lao T.T.H., Thyroid disorders in pregnancy, In: Ian A. Greer, Catherine Nelson-Piercy, Barry Walters, Maternal Medicine (Medical Problems In Pregnancy) . Churchill Livingstone - Elsevier, 2007, 73-77. |
|
Lao T.T.H., 宮腔內程序化過程和子代成人并發症的發生, To attend conference-"Evidence bases medicine and the new progress of management in high risk pregnancy" held by The First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China, December 9, 2006. 國家級繼續教育項目 - "循証医學与產科危重症救治新進展", 主辨: 中山大學附屬第一医院婦產科, 2006. |
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Leung W.C., Chen M., Lau E.T.K., Lao T.T.H. and Tang M.H.Y., Application of rapid aneuploidy detection versus karyotyping in prenatal diagnosis, 產前診斷中常見染色體異常的快速檢測與核型分析技術的應用, Chinese Journal of Obstetrics and Gynecology. (中華婦產科雜志), 2007, 42(5): 348-350. |
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Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Liu R., Kwok Y.L., Li Y., Lao T.T.H. and Zhang X., Skin pressure profiles and variations with body postural changes beneath medical elastic compression stockings, International Journal of Dermatology. 2007, 46(5): 514-523. |
|
Shek N.W.M., Choy M.Y. and Lao T.T.H., Tumour necrosis factor alpha induced insulin resistance in a human first trimester trophoblast cell line , American Journal of Reproductive Immunology. 2007, 57: 325. |
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Wong M.K., Leung W.C., Wang J.K., Lao T.T.H., Ip M.S.M., Lam W.K. and Ho J.C.M., Recurrent pneumothorax in
pregnancy: what should we do after placing an intercostals drain, Hong
Kong Medical Journal. |
|
Wong S.F. and Lao T.T.H., Chapter 25 : SARS and Pregnancy, In: Jane C.K. Chan and Vivian C.W. Taam Wong, Challenges of Severe Acute Respiratory Syndrome. Saunders-Elsevier, 2006, 421-435. |
|
Researcher
: Lau ETK |
|
List of Research Outputs |
|
Hui
P.W., Leung K.Y., Lau E.T.K. and Tang M.H.Y., Confined placental
mosaicism of trisomy 16 presenting with placental mass and intrauterine
death, The 3rd International Scientific Meeting of the International
Society of Ultrasound in Obstetrics & Gynaecology. 25-28 February 2007, |
|
Leung W.C., Chen M., Lau E.T.K., Lao T.T.H. and Tang M.H.Y., Application of rapid aneuploidy detection versus karyotyping in prenatal diagnosis, 產前診斷中常見染色體異常的快速檢測與核型分析技術的應用, Chinese Journal of Obstetrics and Gynecology. (中華婦產科雜志), 2007, 42(5): 348-350. |
|
Researcher
: Lau EYL |
|
List of Research Outputs |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ong C.Y.T., Lee C.P., Leung K.Y., Lau E.Y.L. and Tang M.H.Y., Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0 - Thalassemia Pregnancies, Obstetrics and Gynecology. 2006, 108(3), Part 1: 651-655. |
|
Researcher
: Lee CKF |
|
Project Title: |
Identification of implantation-related genes in mouse uterus: an genomic approach |
|
Investigator(s): |
Lee CKF, Yeung WSB, Yang ZM |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To identify genes that are more directly related to implantation by using LCM. mRNA from specific endometrial cells around the implantation sites of mouse at Day 5.5 of pregnancy will be compared with endometrial cells at the inter-implantation site of the deciduas. |
|
Project Title: |
The molecular interaction between human oviductal embryotrophic factor-3 and embryo |
|
Investigator(s): |
Lee CKF, Luk JMC, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To compare the fecundity of normal and C3-deficient mice; to determine the role of complement activation in the embryotrophic activity of C3; to determine the machinery for the conversion of C3/C3 to iC3b in the oviduct cell coculture system; to define the fragment of iC3b responsible for the embryotrophic activity of the molecule. |
|
Project Title: |
Functional characterization of VAD1.3, a novel acrosome-specific protein by conditional tissue-specific gene inactivation |
|
Investigator(s): |
Lee CKF, Cheah KSE, Yeung WSB, Luk JMC, Lee PY |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To generate VAD1.3 knockout targeting construct; to generate VAD1.3 knockout mice; to produce antibodies against mouse VAD1.3; to analysis the VAD1.3 knockout mice. |
|
Project Title: |
Cloning and functional characterization of demilune cell and parotid protein (Dcpp) gene promoter |
|
Investigator(s): |
Lee CKF, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The objectives of my proposal are (1) to
isolate the promoter region of the mouse demilune cell and parotid protein
(Dcpp) gene promoter, and (2) to characterise the hormonal regulation of the
isolated promoter regions by transfection studies. Demiline cell and parotid
protein (acc. no.: NM_019910, Dcpp, as named as p20) was first isolated from
both sublingual demilune cells and parotid intercalated duct cells in mouse
salivary glands [1] and shared very high homology (99% aa identity) with the
common salivary gland 1 (acc. no.: S76879, CSP1) protein. The gene coding for
Dcpp was located on chromosome |
|
Project Title: |
Functional characterization of a testis-specific Trs4 gene on spermatogenesis by tissue-specific conditional inactivation |
|
Investigator(s): |
Lee CKF, Yeung WSB, Cheah KSE |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To characterize monoclonal antibodies against TRS4; to determine the interacting partners of TRS4; to generate TRS4 conditional knockout targeting construct; to generate TRS4 conditional knockout mice; to phenotype the TRS4 knockout mice. |
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List of Research Outputs |
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Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
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Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
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Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
|
Lee
C.K.F., Liu
Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., A transcriptomic approach
to understand endometrial responses to hormone stimulation in IVF patients. ,
Xian Symposium 2006 on Reproductive Medicine. Sep 16-17, Xian, |
|
Lee
C.K.F., Liu
Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity. , The 1st
CSRM/CSRB Conjoint Annual Meeting. |
|
Lee
C.K.F., Liu
Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity., The 1st
CSRM/CSRB Conjoint Annual Meeting. 7-9 April, |
|
Lee
C.K.F., Ng
P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Expression of olfactomedin
(OLFM) isoforms in human endometrium. , Society for the Study of
Reproduction -39th Annual Meeting. Jul 29-Aug 1, |
|
Lee C.K.F. and Yeung W.S.B., Gamete/embryo - oviduct interactions: implications on in vitro culture., Hum Fertil (Camb). 2006, 9: 137-43. |
|
Lee
C.K.F., Genetic Manipulations to study
spermatogenesis., Frontiers in Biomedical Research, HKU 2006. |
|
Lee
C.K.F., Liu
Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Global gene expression
profiling and endometrial receptivity. , XVIII FIGO World Congress of
Gynecology and Obstetrics. |
|
Lee
C.K.F., Understanding spermatogenesis by gene
inactivation. , Symposium of the 35th Anniversary of the Department of
Biochemistry, The |
|
Lee C.Y.L., Liu Y., Lee C.K.F., Ng E.H.Y. and Yeung W.S.B., Aberrant angiopoietins 1 to 2 and angiopoietin 2 to VEGF ratio in endometrium of excessive ovarian responders during in vitro fertilization treatment, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Lee
C.Y.L., Tse P.K., Chow W.N., Lee C.K.F. and Yeung W.S.B., Hormonal regulation and
convertase activities of complement |
|
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
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Mönkkönen K.S., Aflatoonian R., Lee C.K.F., Yeung W.S.B., Tsao G.S.W., Laitinen J.T., Tuckerman
E.M., Li T.C. and Fazeli A., Localization and variable expression of Galphai |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Characterization of a novel acrosome-expressing protein 2 (AEP2/VAD1.2) during spermatogenesis, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Tam
Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Spatiotemporal
expression of a novel acrosome expressing protein 2 (AEP2/VAD1.2) in
spermatogenesis. , XIX North American Testis Workshop; "Chromosome
Structure and Gene Expression", |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Temporal-spatial expression of a novel acrosome expressing protein 2(AEP2/VAD1.2) in spermatogenesis, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Wong S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Yeung
W.S.B., Lee C.K.F. and Lee C.Y.L., Embryo culture. , XVIII
FIGO World Congress of Gynecology and Obstetrics, |
|
Yeung
W.S.B., Chiu C.N. and Lee C.K.F., An update on
glycodelin-research-its implication in reproductive medicine. , The 1st
Chinese Society of Reproductive Medicine/Chinese Society of Reproductive
Biology Conjoint Annual Meeting. |
|
Yeung
W.S.B., Chiu C.N., Lee C.K.F., Seppala M., Koistinen R.
and Koistinen H., Glycodelin as a modulator of sperm function, |
|
Yeung W.S.B., Lee C.K.F., Koistinen R., Koistinen H., Seppala M., Ho P.C. and Chiu C.N., Glycodelin: a molecule with multi-functions on spermatozoa., Soc Reprod Fertil Suppl. 2007, 63: 143-51. |
|
Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The identification of a zona pellucida binding protein in human spermatozoa., XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
|
Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The regulation of sperm fertilizing capacity by glycodelin, XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
|
Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1.3) using conditional gene knockout approach, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Zuo
Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a
novel acrosome-specific gene (AEP1/VAD1/3) using gene knockout approach. , XIX
North American Testis Workshop: “Chromosome Structure and Gene Expression”,
18-21 April, |
|
Researcher
: Lee CP |
|
List of Research Outputs |
|
Chan C.C.W., Ng E.H.Y., Tang F.O.S., Lee C.P. and Ho P.C., The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus, Gynecological Endocrinology. 2006, 22(9): 516-520. |
|
Chen M., Lee C.P., Lam Y.H., Chan S.M. and Tang M.H.Y., Chinese fetal renal pelvis measurements at 12-14 weeks of gestation, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, 25-28 February, 2007. |
|
Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P. and Tang M.H.Y., Cystic hygroma detected in the first trimester scan, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P., Wong S.F., Tse H.Y. and Tang M.H.Y., Effect of first trimester ultrasound screening on perinatal outcome, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Chen M., Lee C.P., Tang R., Chan B., Ou C.Q. and Tang M.H.Y., First-trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2006, 26(8): 703-706. |
|
Chen M., Lee C.P., Lam Y.H., Ou C. and Tang M.H.Y., First-trimester fetal limb biometry in Chinese population, Prenatal Diagnosis. 2007, 27: 133-138. |
|
Chen M., Lee C.P. and Tang M.H.Y., First-trimester fetal limb biometry in the Chinese population, In: Comments by Dr. Mahmut Tuncay Ozgun for Article (Chen et al., Prenatal Diagnosis 2007; 27:133-138) , Prenatal Diagnosis. 2007, 27: 587. |
|
Chow P.C., Lee S.L., Tang M.H.Y., Chan K.L., Lee C.P., Lam B.C.C. and Tsoi N.S., Management and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung, Hong Kong Medical Journal. 2007, 13(1): 31-39. |
|
Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in fetu – from prenatal suspicion to postnatal confirmation. , The 3rd International Scientific Meeting of the International Society of Ultrasound in Obstetrics & Gynaecology, Hong Kong, 25-28 February 2007. |
|
Leung K.Y., Liao C., Ma S.Y., Chen M., Lee C.P., Lam Y.H. and Tang M.H.Y., 2D and 3D ultrasound prediction of homozygous a thalassemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung K.Y., Liao C., Li Q.M., Ma S.Y., Tang M.H.Y., Lee C.P., Chan V.N.Y. and Lam Y.H., A new strategy for prenatal diagnosis of homozygous a0-thalassemia, Ultrasound Obstetrics and Gynecology. 2006, 28: 173-177. |
|
Leung K.Y., Yin A., Hui P.W., Lee C.P. and Tang M.H.Y., Prenatal Screening for Down Syndrome, JPOG. 2007, 33: 80 - 87. |
|
Leung K.Y., Ngai C.S.W., Lee A.M., Chan H.Y., Leung W.C., Lee C.P. and Tang M.H.Y., The effects on maternal anxiety of two-dimensional versus two-plus three-four-dimensional ultrasound pregnancies at risk of fetal abnormalities: A randomized study, Ultrasound in Obstetrics & Gynecology. 2006, 28: 249-254. |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Comparison of 2D and 3D multi-planar ultrasonography in the prediction of alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Use of 2D and 3D ultrasound to study the growth of fetuses affected by homozygous alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Li T.K.T., Leung K.Y., Lee Y.P., Chan H.Y., Lee C.P. and Tang M.H.Y., Risk of fetal abnormalities after intake of herbal medicinal products and western pharmaceutical products, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Ong C.Y.T., Lee C.P., Leung K.Y., Lau E.Y.L. and Tang M.H.Y., Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0 - Thalassemia Pregnancies, Obstetrics and Gynecology. 2006, 108(3), Part 1: 651-655. |
|
Ting J.Y., Wong K.Y., Goh W.H.S., Lee C.P. and Lam B.C.C., Changes in Mortality,
Morbidity and Early Neurodevelopmental Outcomes among
Extremely-low-birth-weight (ELBW) Infants Born in the Early and Recent
Post-Surfactant Era, |
|
Wang L.M., Leung K.Y., Lee C.P. and Tang M.H.Y., Prenatal evaluation of facial clefts by three-dimensional extended imaging, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Researcher
: Lee CYL |
|
Project Title: |
Effects of C3 deficiency on preimplantation embryo development and implantation potential |
|
Investigator(s): |
Lee CYL, Yeung WSB, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2005 |
|
Abstract: |
|
Coculture of embryo with somatic cells is one of the methods to promote embryo development in vitro. We have shown previously that human oviductal epithelial cells secrete embryotrophic glycoproteins that stimulate the growth of mouse preimplantation embryos in vitro (1, 2). Embryotrophic factor-3 (ETF-3) is one of these factors. ETF-3. It enhances the development of mouse blastocysts resulting in blastocysts with more trophectoderm (TE) cells, larger diameter, higher hatching rate and hatched blastocyst with higher attachment potential and larger trophoblast outgrowth (3, 4). It also affects the expression of a number of genes (NKA-beta 1, PAR-2, cullin-1, ezrin, HSP-70, eIF-2 beta) in the treated blastocysts. Our laboratory recently identified ETF-3 to be complement 3. Its derivative, iC3b increases the preimplantation mouse embryo development in terms of higher blastulation rate, higher hatching rate and larger blastocyst size (5). The objective of this project is to study the effect of C3 knockout in the mouse on the development of the embryo. Similar study in human is difficult, if not impossible. 1. L. P. Liu, S. T. Chan, P. C. Ho, W. S. Yeung, Hum. Reprod 10, 2781 (1995). 2. L. P. Liu, S. T. Chan, P. C. Ho, W. S. Yeung, Hum. Reprod 13, 1613 (1998). 3. J. S. Xu, T. M. Cheung, S. T. Chan, P. C. Ho, W. S. Yeung, Biol Reprod 65, 1481 (2001). 4. Y. L. Lee et al., Biol Reprod 68, 375 (2003). 5. Y. L. Lee et al., J. Biol. Chem. (2003). |
|
List of Research Outputs |
|
Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
|
Lee C.Y.L., Liu Y., Lee C.K.F., Ng E.H.Y. and Yeung W.S.B., Aberrant angiopoietins 1 to 2 and angiopoietin 2 to VEGF ratio in endometrium of excessive ovarian responders during in vitro fertilization treatment, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Lee
C.Y.L., Tse
P.K., Chow W.N., Lee C.K.F. and Yeung W.S.B., Hormonal regulation and
convertase activities of complement |
|
Yeung
W.S.B., Lee C.K.F. and Lee C.Y.L., Embryo culture. , XVIII
FIGO World Congress of Gynecology and Obstetrics, |
|
Researcher
: Lee YW |
|
List of Research Outputs |
|
Lee
Y.W., Liu
V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the
role of AMPK-γ |
|
List of Research Outputs |
|
Hui
P.W., Leung K.Y., Lau E.T.K. and Tang M.H.Y., Confined placental
mosaicism of trisomy 16 presenting with placental mass and intrauterine
death, The 3rd International Scientific Meeting of the International
Society of Ultrasound in Obstetrics & Gynaecology. 25-28 February 2007, |
|
Leung K.Y., Liao C., Ma S.Y., Chen M., Lee C.P., Lam Y.H. and Tang M.H.Y., 2D and 3D ultrasound prediction of homozygous a thalassemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung K.Y., Liao C., Li Q.M., Tang M.H.Y., Lee C.P., Lam Y.H. and Chan V.N.Y., A Non-invasive Approach To Prenatal Diagnosis Of Homozygous ao Thalassemia, XVIII FIGO World Congress of Gnecology and Obstetrics in Kuala Lupmur, Malaysia, 5-10th November 2006. |
|
Leung K.Y., Liao C., Li Q.M., Ma S.Y., Tang M.H.Y., Lee C.P., Chan V.N.Y. and Lam Y.H., A new strategy for prenatal diagnosis of homozygous a0-thalassemia, Ultrasound Obstetrics and Gynecology. 2006, 28: 173-177. |
|
Leung K.Y., Changing pattern of hysterectomies for benign conditions, Hong Kong Medical Journal. 2007, 13(3): 176-177. |
|
Leung K.Y., Yin A., Hui P.W., Lee C.P. and Tang M.H.Y., Prenatal Screening for Down Syndrome, JPOG. 2007, 33: 80 - 87. |
|
Leung K.Y., Ngai C.S.W., Lee A.M., Chan H.Y., Leung W.C., Lee C.P. and Tang M.H.Y., The effects on maternal anxiety of two-dimensional versus two-plus three-four-dimensional ultrasound pregnancies at risk of fetal abnormalities: A randomized study, Ultrasound in Obstetrics & Gynecology. 2006, 28: 249-254. |
|
Leung K.Y., Ultrasound prediction of homozygous a-thalassemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Comparison of 2D and 3D multi-planar ultrasonography in the prediction of alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Use of 2D and 3D ultrasound to study the growth of fetuses affected by homozygous alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Li T.K.T., Leung K.Y., Lee Y.P., Chan H.Y., Lee C.P. and Tang M.H.Y., Risk of fetal abnormalities after intake of herbal medicinal products and western pharmaceutical products, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Ong C.Y.T., Lee C.P., Leung K.Y., Lau E.Y.L. and Tang M.H.Y., Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0 - Thalassemia Pregnancies, Obstetrics and Gynecology. 2006, 108(3), Part 1: 651-655. |
|
Wang L.M., Leung K.Y. and Tang M.H.Y., Prenatal evaluation of facial clefts by three-dimensional extended imaging, Prenatal Diagnosis. 2007, 27: 722-729. |
|
Wang L.M., Leung K.Y., Lee C.P. and Tang M.H.Y., Prenatal evaluation of facial clefts by three-dimensional extended imaging, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Wong B.P.Y., Leung K.Y., Tang R., Tai C.M. and Ng T.K., Conservative management of acardiac twin pregnancies: two case reports and literature review, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Yin A., Ng E.H.Y., Zhang X., He Y., Wu J. and Leung K.Y., Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding, Human Reproduction. 2007, 22(6): 1736-1743. |
|
Researcher
: Leung TW |
|
List of Research Outputs |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Comparison of 2D and 3D multi-planar ultrasonography in the prediction of alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Use of 2D and 3D ultrasound to study the growth of fetuses affected by homozygous alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
|
Researcher
: Leung WC |
|
List of Research Outputs |
|
Au W.Y. and Leung W.C., Challenges and pitfalls in prenatal screening in pregnancies involving allogeneic stem cell transplantation recipients, Bone Marrow Transplantation. 2007, 39(7): 379-382. |
|
Brownridge
D.A., Chan E.K.L., Hiebert-Murphy
D., Ristock J., Tiwari A.F.Y., Leung W.C. and Santos S.U.S.Y. .C.,
The Elevated Risk for Non-Lethal Post-Separation Violence in |
|
Brownridge
D.A., Chan E.K.L., Hiebert-Murphy
D., Ristock J., Tiwari A.F.Y. and Leung W.C., The elevated risk for
non-lethal post-separation violence in |
|
Chan E.K.L., Tiwari A.F.Y., Leung W.C., Ho H.W.Y. and Cerulli C., Common Correlates of Suicidal Ideation and Physical Assault among Male and Female University Students in Hong Kong, Violence and victims. 2007, 22(3): 290-303. |
|
Chan E.K.L., Tiwari A.F.Y., Fong D.Y.T., Leung W.C., Brownridge D.A. and Ho P.C., Correlates of in-law conflict with intimate partner violence against pregnant women, Journal of Interpersonal Violence, 2007, (forthcoming). 2007. |
|
Chan E.K.L., Brownridge D.A., Leung W.C., Tiwari A.F.Y. and Ho H.W.Y., Mental health profile of sexual violence perpetrators among university students in Hong Kong., Family Relations: Behavioral, Psychological and Sociological Aspects. . Nova Publishers, 2007. |
|
Chan
E.K.L., Tiwari A.F.Y. and Leung W.C., Screening & Risk
Assessment for Violence in Health Setting, In: organized by the University of
Hong Kong, Hong Kong. November 24,, Presented at the Conference on
Violence in |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Leung K.Y., Ngai C.S.W., Lee A.M., Chan H.Y., Leung W.C., Lee C.P. and Tang M.H.Y., The effects on maternal anxiety of two-dimensional versus two-plus three-four-dimensional ultrasound pregnancies at risk of fetal abnormalities: A randomized study, Ultrasound in Obstetrics & Gynecology. 2006, 28: 249-254. |
|
Leung W.C., Chen M., Lau E.T.K., Lao T.T.H. and Tang M.H.Y., Application of rapid aneuploidy detection versus karyotyping in prenatal diagnosis, 產前診斷中常見染色體異常的快速檢測與核型分析技術的應用, Chinese Journal of Obstetrics and Gynecology. (中華婦產科雜志), 2007, 42(5): 348-350. |
|
Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Tiwari A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner violence: Comparing the Chinese Abuse Assessment Screen with the Revised Conflict Tactics Scales, BJOG, 2007, (forthcoming). 2007. |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The First Territory-wide Survey
on Intimate Partner Violence against Pregnant Women in Hong Kong, In:
organized by the University of Hong Kong, Hong Kong. November 24,, Presented
at the Conference on Violence in |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The first territory-wide survey
on intimate partner violence against pregnant women in |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., The prevalence of intimate
partner violence among pregnant women in Hong Kong, International
Conference: Violence Against Women: Diversifying Social Responses. |
|
Tiwari
A.F.Y., Chan E.K.L., Fong D.Y.T., Leung W.C. and Ho P.C., Validation of a violence
screening tool as common language for health and social work professionals, 5th
International Conference on Social Work in Health and Mental Health. |
|
Wong M.K., Leung W.C., Wang J.K., Lao T.T.H., Ip M.S.M., Lam W.K. and Ho J.C.M., Recurrent pneumothorax in
pregnancy: what should we do after placing an intercostals drain, Hong
Kong Medical Journal. |
|
Researcher
: Li ICF |
|
List of Research Outputs |
|
Tam K.F., Ng T.Y., Tsang P.C.K., Li I.C.F. and Ngan H.Y.S., Potential use of the adenosine triphosphate cell viability assay in endometrial cancer, Journal of The Society for Gynecology Investigation. 2006, 13(7): 518-522. |
|
Researcher
: Liu S |
|
List of Research Outputs |
|
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
|
Tam K.F., Cheung A.N.Y., Liu S., Xue W. and Ngan H.Y.S., Expression of Matrix Metalloproteinases and tissue inhibitors of metalloproteinases in atypical complex endometrial hyperplasia with and without associated malignancy, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
|
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
|
Researcher
: Liu VWS |
|
Project Title: |
Effect of controlled c-myc and p53 expression on mitochondrial biogenesis in ovarian cancer |
|
Investigator(s): |
Liu VWS, Ngan HYS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
PURPOSE OF PROPOSED
INVESTIGATIONRecently, the mitochondrial content changes in tumour have been
found to correlate with the tumour behaviours. C-myc and p53 are demonstrated
to be important in controlling mitochondrial biogenesis. The purpose of this
proposal is to investigate the effect of c-myc and p53 expression on
mitochondrial biogenesis in ovarian cancer.BACKGROUND AND HYPOTHESISIn 1930,
Warburg hypothesized that cancer cells might have impaired mitochondrial
function and sufficient ATP production for cell growth was mainly provided by
an elevated glycolytic pathway. Nowadays, this so called "Warburg
effect" was known to be a common characteristic of most tumours.
Mitochondrial oxidative phosphorylation (OXPHOS) is the bioenergetic pathway
for the synthesis of most ATP for normal cellular activities. The normal
activity of OXPHOS is also required for the execution of cell apoptosis.
Recently, a number of reports demonstrated the down-regulation of
mitochondrial content but the presence of up-regulated glycolytic markers in
several human cancers. Low mitochondrial content in tumor cell has been
related to aggressive behavior of tumour. In addition to the nuclear-encoded
polypeptide subunits of mitochondrial OXPHOS complexes, the mitochondrial genome
encodes for 13 polypeptides that are subunits of complexes I, III, IV and V,
respectively. Interestingly, both increased and decreased mitochondrial DNA
(mtDNA) copy number and mitochondrial gene expression have been reported in
human cancers. MtDNA mutations have also been demonstrated to cause cancer,
increase tumourigenicity and promote cancer growth by prevention of
apoptosis.Although the mechanism leading to the Warburg effect has not been
clear for many years, increasing evidence suggests that abnormal expression
of oncogenes such as c-myc and/or tumour suppressor genes such as p53 may be
the underlying mechanism that drives the Warburg effect and eventually leads
to tumour formation. Under normal circumstances, both c-myc and p53 have been
found to regulate glycolysis and mitochondrial respiration.I have previously
reported the occurrence of high frequency (60%) of somatic mtDNA mutations in
ovarian cancer (1). In addition, it was found that mtDNA copy numbers in high
grade ovarian tumors were significantly lower than that in low grade tumors
(2). In an ongoing study, a few nuclear-encoded polypeptides of complex I was
found to be down-regulated. I hypothesize that mitochondrial content change
may play a significant role in ovarian cancer development. Furthermore, the
c-myc gene has been found to be overexpressed or amplified in about 30-50% of
ovarian cancer. And about 50% of human tumors lack a functional p53 gene. The
most common subtype of ovarian cancer, high-grade serous carcinoma, is characterized
by p53 mutations. I hypothesize that aberrant expression of c-myc and/or p53
may be responsible for the mitochondrial content changes in ovarian
cancer.PROJECT OBJECTIVES:(1) To measure the levels of mitochondrial markers
in various ovarian cancer cell lines and determine the potential roles of
c-myc and p |
|
List of Research Outputs |
|
Chan
D.W., Liu V.W.S. and Ngan H.Y.S., Loss of MKP3 is associated
with cisplatin-resistance and tumorigenicity of ovarian cancer, Hong Kong
International Cancer Congress, |
|
Chan
D.W., Liu V.W.S., Furukawa
T., Tsao G.S.W., Yao K.M., Chan K.K.L. and Ngan H.Y.S., Loss of MKP3 is associated
with cisplatin-resistance and tumorigenicity of ovarian cancer, American
Association for Cancer Research. Annual Meeting 2007. |
|
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
|
Lee
Y.W., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the role
of AMPK-γ |
|
Liu
V.W.S., Chan
D.W. and Ngan H.Y.S., High
frequency of promoter hypermethylation of metallothionein 1E in endometrial
carcinomas, American Association for Cancer Research. Annual Meeting 2007 |
|
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
|
To
M.Y., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the
role of FOXG1B in the development of ovarian cancer, The 11th Research
Postgraduate Symposium 2006, The |
|
Wang Y., Liu V.W.S., Xue W., Cheung A.N.Y. and Ngan H.Y.S., Association of decreased mitochondrial DNA content with ovarian cancer progression , British Journal of Cancer. 2006, 95: 1087-1097. |
|
Wang Y., Xue W., Liu V.W.S. and Ngan H.Y.S., Detection of Mosaic Pattern of Mitochondrial DNA Alterations in Different Populations of Cells from the Same Endometrial Tumor, Mitochondrion. Elsevier, 2007, 7: 171-175. |
|
Yang H., Liu V.W.S., Wang Y., Tsang P.C.K. and Ngan H.Y.S., Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data, BMC Cancer. 2006, 6: 212. |
|
Yu Y.M., Liu V.W.S. and Ngan H.Y.S., AMP-activated Protein Kinase Reduced Cervical Cancer Cell Death under Glucose Deprivation, Hong Kong International Cancer Congress, Hong Kong, 15-17 Dec . 2006. |
|
Yu
Y.M., Liu V.W.S. and Ngan H.Y.S., Functional analysis of AMPK
activity in cervical cancer cells, European Cytokine Network (Volume 17,
Supplement August 2006. Cytokines 2006- |
|
Researcher
: Liu Y |
|
List of Research Outputs |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., A transcriptomic approach
to understand endometrial responses to hormone stimulation in IVF patients. ,
Xian Symposium 2006 on Reproductive Medicine. Sep 16-17, Xian, |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity. , The 1st
CSRM/CSRB Conjoint Annual Meeting. |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF cycles
on global endometrial gene expression and receptivity., The 1st CSRM/CSRB
Conjoint Annual Meeting. 7-9 April, |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Global gene expression
profiling and endometrial receptivity. , XVIII FIGO World Congress of
Gynecology and Obstetrics. |
|
Lee C.Y.L., Liu Y., Lee C.K.F., Ng E.H.Y. and Yeung W.S.B., Aberrant angiopoietins 1 to 2 and angiopoietin 2 to VEGF ratio in endometrium of excessive ovarian responders during in vitro fertilization treatment, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Researcher
: Ng EHY |
|
Project Title: |
Single or multiple biopsies for retrieval of spermatozoa from the testis? |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
03/1999 |
|
Abstract: |
|
To compare the recovery rate of testicular spermatozoa after single vs. multiple open testicular biopsies; to compare the testicular function after single vs. multiple open testicular biopsies. |
|
Project Title: |
To study the endometrial receptivity before and after removing intramural fibroids |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2000 |
|
Abstract: |
|
To compare endometrial receptivity in patients having intramural fibroids before and after myomectomy. |
|
Project Title: |
A randomized comparison of side effects of two vaginal progesterone preparations used for luteal support in assisted reproduction cycles using pituitary down regulation |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/2000 |
|
Abstract: |
|
To compare the side effects of two vaginal progesterone preparations used for luteal support in assisted reproduction cycles using pituitary down regulation. |
|
Project Title: |
The value of increasing starting dose of gonadotrophin during ovarian stimulation in women with <= 6 antral follicles prior to stimulation |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
08/2000 |
|
Abstract: |
|
To determine the value of increasing starting dose of gonadotrophin during ovarian stimulation in women with <= 6 antral follicles prior to stimulation. |
|
Project Title: |
Comparison of the prevalence of polycystic ovary only and polycystic ovary syndrome between two different ethnic populations |
|
Investigator(s): |
Ng EHY, Chan CW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
The objective of this study is To define the prevalence of polycystic ovary only and polycystic ovary syndrome and its associated hormonal and biochemical profiles in Chinese and Indian populations. |
|
Project Title: |
The role of anti-Müllerian hormone in the prediction of livebirth rate and cumulative livebirth rate during in vitro fertilization treatment |
|
Investigator(s): |
Ng EHY, Yeung WSB, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To determine and compare the predictive values of serum FSH, serum AMH and AFC in livebirth and cumulative livebirth rates following in vitro fertilization treatment. This study will provide information on these predictive values and help in counselling patients with regard to the livebirth rate prior to the IVF treatment. |
|
List of Research Outputs |
|
Chan C.C.W., Ng E.H.Y., Tang F.O.S., Lee C.P. and Ho P.C., The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus, Gynecological Endocrinology. 2006, 22(9): 516-520. |
|
Chan V.N.Y., Ng E.H.Y., Yam I.Y.L., Yeung W.S.B., Ho P.C. and Chan T.K., Experience in preimplantation genetic diagnosis for exclusion of homozygous ao thalassaemia, Prenatal Diagnosis. 2006, 26: 1029-1036. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Kan A.S.Y., Caves N., Wong S.Y.W., Ng E.H.Y. and Ho P.C., A double-blind randomised controlled trial on the use of Entonox in pain relief during suction evacuation for the trimester pregnancy termination, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Kan A.S.Y., Caves N.D., Wong S.Y.W., Ng E.H.Y. and Ho P.C., A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination, Human Reproduction. 2006, 21(10): 2606-2611. |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., A transcriptomic approach
to understand endometrial responses to hormone stimulation in IVF patients. ,
Xian Symposium 2006 on Reproductive Medicine. Sep 16-17, Xian, |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity. , The 1st
CSRM/CSRB Conjoint Annual Meeting. |
|
Lee
C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF
cycles on global endometrial gene expression and receptivity., The 1st
CSRM/CSRB Conjoint Annual Meeting. 7-9 April, |
|
Lee
C.K.F., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Expression of olfactomedin
(OLFM) isoforms in human endometrium. , Society for the Study of
Reproduction -39th Annual Meeting. Jul 29-Aug 1, |
|
Lee
C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Global gene expression
profiling and endometrial receptivity. , XVIII FIGO World Congress of
Gynecology and Obstetrics. |
|
Lee C.Y.L., Liu Y., Lee C.K.F., Ng E.H.Y. and Yeung W.S.B., Aberrant angiopoietins 1 to 2 and angiopoietin 2 to VEGF ratio in endometrium of excessive ovarian responders during in vitro fertilization treatment, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized comparison of side effects and patient convenience between CyclogestÒ suppositories and EndometrinÒ tablets used for luteal phase support in IVF treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 131: 182-188. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ng E.H.Y. and Ho P.C., Ageing and ART: A waste of time and money?, Best Practice and Research Clinical Obstetrics and Gynaecology. 2007, 21(1): 5-20. |
|
Ng
E.H.Y., Clinical studies on endometrial
receptivity, XVIII FIGO World Congress of Gynecology and Obstetrics,
November 5-10, 2006, |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26: 931-939. |
|
Ng E.H.Y., Doppler ultrasound for ovarian reserve and endometrial receptivity, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with live birth following assisted reproduction treatment than in those who suffer a miscarriage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage, Human Reproduction. 2007, 22(4): 1134-1141. |
|
Ng E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Management of male subfertility, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, Jan/Feb 2007: 37-43. |
|
Ng E.H.Y., Optimal gonadotrophin regimen for assisted reproduction, Forth International Huaxia Congress of Endocrinology organized by Hong Kong Society of Endocrinology, Metabolism and Reproductive and Diabetes, December 15-18, 2006, Hong Kong. 2006. |
|
Ng
E.H.Y., Ovarian stromal vacularity as an
ovarian reserve test, XVIII FIGO World Congress of Gynecology and
Obstetrics, November 5-10, 2006, |
|
Ng E.H.Y., Yeung W.S.B. and Ho P.C., Patients with three or less dominant follicles may not be associated with reduced pregnancy rate of in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2006, 129: 54-59. |
|
Ng E.H.Y., Polycystic ovary syndrome , Joint Scientific Meeting of the Nuffield Visiting Society and Department of Obstetrics and Gynaecology, The University of Hong Kong, May 18, 2007. 2007. |
|
Ng E.H.Y., Prediction of IVF outcome by ultrasound, The 20th Anniversary Symposium on IVF, organized by Department of Obstetrics and Gynaecology, The University of Hong Kong and IVF Centre, Hong Kong Sanatorium and Hospital, 11-12 November, 2006, Hong Kong. 2006. |
|
Ng E.H.Y., Preimplantation genetic diagnosis-where are we now?, Monthly prenatal diagnosis seminar organized by Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, March 10, 2007, Hong Kong. 2007. |
|
Ng E.H.Y., Significance of excessive ovarian response during IVF, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
|
Ng E.H.Y., The use of 3D ultrasound in general gynaecology and assisted reproduction, The Third program of three-dimensional ultrasound in Obstetrics and Gynaecology, The University of Hong Kong, 2-3 December, 2006, Hong Kong. 2006. |
|
Ng E.H.Y., Treatment of Subfertility, Compulsory lectures for Community Gynaecology organized by The Hong Kong College of Obstetricians and Gynaecologists, Hong Kong, July 22, 2006. 2006. |
|
Ng E.H.Y., Update on infertility and assisted reproduction technology, Certificate course in gynaecology organized by Hong Kong Society of Obstetricians and Gynaecologists in Hong Kong, March 21, 2007. 2007. |
|
Ng E.H.Y., Use of three-dimensional ultrasound in assisted reproduction, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. 2007. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Tam P.C., Wong S.C.W., Ho K.L. and Ng E.H.Y., Serum FSH as predictive factor for successful sperm recovery in non-obstructive zoospermic patients, American Urological Association Annual Meeting, Anaheim, U.S.A., 19-24 May, 2007. |
|
Yin A., Ng E.H.Y., Zhang X., He Y., Wu J. and Leung K.Y., Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding, Human Reproduction. 2007, 22(6): 1736-1743. |
|
Researcher
: Ng PPY |
|
List of Research Outputs |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Researcher
: Ng PY |
|
List of Research Outputs |
|
Lee C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF cycles on global endometrial gene expression and receptivity. , The 1st CSRM/CSRB Conjoint Annual Meeting. Hangzhou, China.. 2007. |
|
Lee C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF cycles on global endometrial gene expression and receptivity., The 1st CSRM/CSRB Conjoint Annual Meeting. 7-9 April, Hangzhou, China.. 2007, P.204. |
|
Lee C.K.F., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Expression of olfactomedin (OLFM) isoforms in human endometrium. , Society for the Study of Reproduction -39th Annual Meeting. Jul 29-Aug 1, Omaha, Nebraska, USA.. 2006, P.350. |
|
Researcher
: Ng TY |
|
Project Title: |
A propective randomised controlled trial: prevention of lymphedema by omentoplasty after pelvic lymphadenectomy |
|
Investigator(s): |
Ng TY, Ngan HYS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To see whether these preliminary results are validated in a prospective randomised comparison. |
|
Project Title: |
A prospective randomized controlled trial: prevention of Lymphedema by Omentoplasty after pelvic lymphadenectomy |
|
Investigator(s): |
Ng TY, Ngan HYS, Chan YM, Tam KF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Health and Health Services Research Fund - Full Grants |
|
Start Date: |
04/2004 |
|
Abstract: |
|
Lymphedema is a debilitating condition that occurs in up to 40% of patients after pelvic lymphadenectomy. New surgical techniques have been advocated to reduce this complication. A pilot study using Omentoplasty observed that 8% of patients after this procedure had clinical lymphedema compared with 40% in historical controls. This study aims to see whether these preliminary results are validated in a prospective randomised comparison. |
|
List of Research Outputs |
|
Tam K.F., Ng T.Y., Tsang P.C.K., Li I.C.F. and Ngan H.Y.S., Potential use of the adenosine triphosphate cell viability assay in endometrial cancer, Journal of The Society for Gynecology Investigation. 2006, 13(7): 518-522. |
|
Researcher
: Ngai CSW |
|
Project Title: |
Vaginal misoprostol for first trimester termination of pregnancy prior to 9 weeks of gestation |
|
Investigator(s): |
Ngai CSW, Tang FOS, Chan YM, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Health Services Research Fund - Full Grants |
|
Start Date: |
05/1999 |
|
Abstract: |
|
To compare the effectiveness of vaginal misoprostol (water vs no water added) in first trimester termination of pregnancy. |
|
Project Title: |
Cervical assessment in prediction of preterm labour: is three-dimensional ultrasonography a better choice? |
|
Investigator(s): |
Ngai CSW, Lao TTH, Chen M, Leung KY |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To compare the usefulness of 3D versus 2D US in prediction of preterm labour. |
|
Project Title: |
Multiple pregnancy and gestational diabetes: a physiological response or a pathologic condition? |
|
Investigator(s): |
Ngai CSW, Lao TTH, Leung WC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To investigate the incidence of gestational disbetes mellitus in twin pregnancy; to investigate the changes of glucose metabolism throughout pregnancy in multiple pregnancy; to evaluate the diagnostic criteria of gestational diabetes mellitus in twin pregnancy. |
|
List of Research Outputs |
|
Kwok K.Y., Tang M.H.Y., Law H.K.W., Ngai C.S.W., Lau Y.L. and Lau E.T., Maternal plasma or human serum albumin in wash buffer enhances enrichment and ex vivo expansion of human umbilical cord blood CD34+ cells, British Journal of Haematology. Blackwell, 2007, 137 (5): 468-474. |
|
Leung K.Y., Ngai C.S.W., Lee A.M., Chan H.Y., Leung W.C., Lee C.P. and Tang M.H.Y., The effects on maternal anxiety of two-dimensional versus two-plus three-four-dimensional ultrasound pregnancies at risk of fetal abnormalities: A randomized study, Ultrasound in Obstetrics & Gynecology. 2006, 28: 249-254. |
|
Ngai C.S.W., Tang F.O.S. and Ho P.C., Drugs for second trimester termination of pregnancy, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 147-153. |
|
Researcher
: Ngan ESW |
|
Project Title: |
Sonic hedgehog (Shh) signaling in the enteric neural crest cells |
|
Investigator(s): |
Ngan ESW, Sham MH, Lui VCH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
The main objectives of this project are:
1) To investigate the effect of Shh on the expression profiles of BMP-2 and
BMP |
|
Project Title: |
Novel Function(s) of Prokineticins in Neural Crest Stem Cells |
|
Investigator(s): |
Ngan ESW, Lui VCH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The mammalian enteric nervous system
(ENS) is derived from the neural crest cells (NCC) which enter the foregut and
colonize the entire wall of gastrointestinal tract (1). In mice, NCCs reach
foregut at approximately embryonic day 9.4 (E9.5) and finish the colonization
by ~E14.5. Numerous gut mesenchyme/mucosa-derived factors and their receptors
on NCC are found to be crucial for NCC proliferation, differentiation and
migration. They are glial cell-line derived neurotrophic factor (GDNF) and
its receptors (RET, GFRA1)(2); endothelin 3 (EDN3) and its receptor
(EDNRB)(3); sonic hedgehog (Shh) and its receptor (Ptc)(4). A delicate
balance between these signals is a prerequisite for the proper regulation of
NCCs during ENS development. Failure to completely colonize the gut results
in the absence of enteric ganglia as seen in Hirschsprung’s disease in
human.. Prokineticin –1 and -2 (Prok-1 and Prok-2), also referred to
endocrine gland derived vascular endothelial growth factor (EG-VEGF) and Bv8,
respectively, are structurally related and belong to a newly identified
family of secreted proteins, AVIT protein family. These proteins are
distributed widely in mammalian tissues. Prok-1 mRNA expression has been
described in a variety of tissues, in steroidogenic glands such as the ovary,
testis, adrenal gland and placenta, but also in the brain, colon, skeletal
muscle, small intestine, spleen, thymus liver, bladder, prostate and
uterus(5,6) . Prok-2, on the other hand, shows the highest expression in
testis, colon, brain and peripheral blood leukocytes(7,8). These two
prokineticins are known to bind to two closely related G protein-coupled
receptors, PK-R1 and PK-R2. Receptor activation leads to mobilization of
calcium, stimulation of phosphoinositide turnover, and activation of p44/p42
MAPK signaling pathways. Within distinct contexts, the receptors are likely
differentially regulated and distinct expression patterns of Prok receptors
were observed in various tissues. In the adrenal gland, only PK-R1 was
detected. In the ovary, follicular cells predominantly express PK-R1, whereas
corpus luteum-derived cells express high levels of both PK-R1 and PK-R2.
Similarly, these two receptors are also co-existing in endometrium, but at
different expression level. Therefore, it is believed that prokineticins may
have different angiogenic as well as non-angiogenic functions in different
tissues via acting on either PK-R1 or PK-R2. However, the exact role(s) of
PK-R1 and PK-R2 remains unclear. A new appreciation for the intricacy of
peptidergic GPCRs is developing, as the ligands for orphan receptors are
identified and as distinct signaling and functional responses for multiple
ligands and oligomerized receptors are demonstrated. Thus, the distinct or
overlapping expression of prokineticins and the possible heteroligomerization
of receptors may increase the functional complexity of this system (8,9). It
is currently known that prokineticins possess diverse biological functions:
they promote angiogenesis in ovary and testis; induce proliferation,
migration and fenestration of endothelial cells derived from adrenal gland ;
support neuronal survival; cause hyperalgesia of skin; promote contraction of
gastrointestinal smooth muscle; and control pain sensation and behavioral
circadian rhythms(8,9). More recently, these two receptors were also found in
human and mouse hematopoietic stem cells and specific mature blood cells,
including lymphocytes. Prokineticins can modulate growth, survival, and
function of cells of the innate and adaptive immune systems, possibly through
autocrine or paracrine signaling mechanisms(7). Given the reported expression
patterns and activities of the mammalian orthologs in brain, reproductive
tract, and cells of the immune system, the molecules seem to have subserved
similar functions across evolution. In addition to being the angiogenic
factors, prokineticins would be the universal survival/mitogenic factors for
various cells including endothelial cells, neuronal cells, lymphocytes as
well as the hematopietic stem cells. Noteworthy, prokineticins and their
receptors were detected in mouse embryo as early at E7, the role(s) of these
factors during embryonic development still remains to be disclosed. Our
preliminary data: It is known that prokineticin-1 is expressed in mouse and
human small intestine and colon. Using antibody specific to Prok-1 to perform
the immunohistochemistry study, we found that Prok-1 protein is expressed in
the mucosa and enteric neuronal plexus of the gut in the adult mouse. The
presence of Prok |
|
Project Title: |
Is thyroid transcription factor (TTF-1) the susceptibility gene for familial papillary thyroid carcinoma (PTC) predisposition |
|
Investigator(s): |
Ngan ESW, Garcia-Barcelo MM, Tam PKH, Lo CY, Khoo US |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Papillary thyroid carcinoma (PTC) is the
most common malignant thyroid carcinoma, comprising an estimated 80% of
thyroid cancers. Somatic genetic alterations in PTC, including RET/PTC
rearrangements(1-4) and BRAF(5) and RAS(6) mutations have proved useful as
prognostic markers and may represent the result to a cancer initiation
process governed by the constitutive DNA endowment of the patient.
Nevertheless, these genetic alterations only account for approximately 70% of
PTC and the correlations with clinicopathological features of increase
morbidity are still inconclusive. Importantly, 3.5-6.2% of PTC patients have
one or more first-degree relatives with thyroid carcinoma, suggesting the
presence of heritable genetic determinants for PTC predisposition, but the
genetic basis of familial PTC is yet unknown. Thyroid transcription factor-1
(TTF-1) is a key player implicated in the thyroid development and associated
disorders. TTF-1 knockout mice present with a series of congenital defects
including lack of thyroid(7). Heterozygous "de novo" TTF1 mutations
inherited in an autosomal dominant manner are associated with compensated
congenital hypothyroidism(8-10). Regarding tumorigenesis, it is known to be a
differentiation marker and inversely related to the malignant phenotype of
thyroid neoplasms. More recently, it has been demonstrated that conditional
ablation of TTF |
|
List of Research Outputs |
|
Researcher
: Ngan HYS |
|
Project Title: |
High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer |
|
Investigator(s): |
Ngan HYS, Wong RLC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1994 |
|
Abstract: |
|
To study high dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer. |
|
Project Title: |
Rapid identification of tumour-specific gene methylation at multiple loci in gynaecological cancers |
|
Investigator(s): |
Ngan HYS, Liu VWS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To determine and differentiate the methylation status for 30 gene loci among the three gynaecological cancers using a pooled DNA approach. |
|
Project Title: |
Functional analysis of AMP-activated protein kinase (AMPK) in cervical cancer cell growth |
|
Investigator(s): |
Ngan HYS, Liu VWS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2005 |
|
Completion Date: |
10/2006 |
|
Abstract: |
|
Introduction: Cervical carcinoma is the
most common cancer of the female genital tract and is still a major cause of
morbidity and mortality in women of Hong Kong. Human papillomaviruses (HPVs)
have been found in nearly all cases of cervical cancer, and it has been well
established to be an important aetiological factor for the development of the
cancer (zur Hausen, 2002). Although HPV infection is generally believed to be
the initiating factor for cervical cancer development, the number of HPV
infected women is much higher than the number of women with cervical cancer.
Therefore, the transformation from low-grade lesion to invasive cancer must
involve other factors such as cellular genetic changes affecting oncogenes
and/or tumor suppressor genes. Our preliminary work: Consistent with other
studies, we have been able to detect frequent amplifications of chromosomal
regions at 5p and 3q in cervical tumors and cervical cancer cell lines using
comparative genomic hybridization (CGH) technology (Huang et al, 2005). This
suggests that 5p and 3q may harbor putative oncogenes that may play an
important role in the development of cervical cancer through gene
amplification and over-expression. Subsequently, four specific genes located
on the chromosome 5 have been randomly selected, including the catalytic
alpha-1 subunit of the AMP-activated protein kinase (AMPK alpha-1) (at 5p12),
polymerase (DNA directed) sigma (POLS) (at 5p15), delta 2 catenin (CTNND2)
(at 5p15.2) and ERBB2 interacting protein (ERBB2IP) (at 5q12.3), for gene
copy number measurement using fluorescent PCR. Table 1 indicates the degrees
of gene amplification of the above four genes in various cervical cancer cell
lines compared with DNA from normal lymphocyte. Results indicate that all the
four genes were amplified in cervical cancer cell lines (Huang et al,
manuscript submitted for publication). The greatest fold of amplification was
seen in the AMPK alpha-1 gene ranging from 2.8 to 6.3. TABLE 1. Degrees of
gene amplification measured by semi-quantitative fluorescent PCR Cell lines
AMPK alpha-1 POLS CTNND2 ERBB2IP CasKi 6.1 2.0 3.5 |
|
Project Title: |
Study of human papillomavirus status in Southern Chinese women with normal cervix, precancerous cervical lesions and cervical cancers |
|
Investigator(s): |
Ngan HYS, Cheung ANY, Chan YK, Fong DYT, Lo SST, Lin ZQ |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
10/2006 |
|
Abstract: |
|
This cross-sectional study will investigate the current spectrum and prevalence of HPV circulating among healthy females in Guangdong and Hong Kong. The integration of the high risk HPVs in relation to precancerous cervical lesion and cervical cancer in both regions will be assessed with epidemiological data. The data yielded will be compared between these two regions. |
|
Project Title: |
Potential interaction between Zic2 and Gli proteins in enhancing the oncogenic role of hedgehog signaling in cervical cancer |
|
Investigator(s): |
Ngan HYS, Chan DW, Liu VWS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
PURPOSE OF PROPOSED INVESTIGATION The
purpose is to investigate the roles of Hedgehog signaling in the development
of cervical cancer, and functionally characterize whether Zic2, one of the
zinc finger proteins, synergistically enhances the oncogenic role of hedgehog
signaling in cervical cancer . HYPOTHESISCervical cancer, a potentially
preventable disease, remains the second most common malignancy in women
worldwide. Human papillomavirus (HPV) is the single most important
etiological agent in cervical cancer, contributing to neoplastic progression
through the action of viral oncoproteins, mainly E6 and E7, which interfere
with critical cell cycle pathways, p53 and retinoblastoma, respectively.
However, evidence suggests that human papillomavirus infection alone is
insufficient to induce malignant changes. Therefore, the transformation from
low-grade lesion to invasive cancer must involve other cellular genetic
changes affecting oncogenes, tumour suppressor genes or signal transduction
pathway. Hedgehog signaling pathway and cervical cancerThe Hedgehog signaling
pathway (HHS) was identified two decades ago in Drosophila as a critical
regulatory mechanism of cell-fate determination during embryogenesis
(Nusslein-Volhard C, Wieschaus E, 1980). In mammals there are three Hh-family
proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh). Gene-targeting
experiments in mice have demonstrated that the development and patterning of
essentially every major organ requires input from the Hh pathway (Ingham PW
and McMahon AP, 2001). The Hh-signaling pathway comprises three main
components: the Hh ligand; a transmembrane receptor circuit composed of the
negative regulator Patched (PTCH) plus an activator, Smoothened (Smo); and
finally a cytoplasmic complex that regulates the Cubitus interruptus (Ci) or
Gli family of transcriptional effectors which include Gli1, Gli2, and Gli3.
Aberrant activation of the HHS pathway has been documented in promoting cell
poroliferation, tumor growth and metastasis in skin (Couve-Privat et al.,
2004; Cui et al., 2004; Athar et al., 2006), prostate (Fan et al., 2004;
Sanchez et al., 2004; Karhadkar et al., 2004) and hepatocellular carcinomas
(Huang et al., 2006). This indicates the significant role of HHS in cancer
development. However, the roles of HHS in cervial cancer remains unknown.
However, a recent report has shown that the expression levels of Gli1, Gli2
and Gli |
|
List of Research Outputs |
|
Au C.W.H., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., Tropomyosin-related kinase B and brain-derived neurotrophic factor in ovarian cancer. [abstract]., In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18; Los Angeles, CA. Philadelphia (PA): AACR; Abstract nr 3771. 2007. |
|
Beller U., Benedet J.L., Creasman W.T., Ngan H.Y.S., Quinn M.A., Maisonneuve P., Pecorelli S., Odicino F. and Heintz A.P., Carcinoma of the vagina, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S29-42. |
|
Beller U., Quinn M.A., Benedet J.L., Creasman W.T., Ngan H.Y.S., Maisonneuve P., Pecorelli S., Odicino F. and Heintz A.P., Carcinoma of the vulva, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S7-27. |
|
Cain J., Denny L. and Ngan H.Y.S., Overcoming barriers to the eradication of cervical cancer: women's health and rights, International Journal of Gynecology and Obstetrics. 2007, 97(3): 232-234. |
|
Chan D.W., Liu V.W.S. and Ngan H.Y.S., Loss of MKP3 is associated with cisplatin-resistance and tumorigenicity of ovarian cancer, Hong Kong International Cancer Congress, Hong Kong, 15-17 Nov. 2006. |
|
Chan D.W., Liu V.W.S., Furukawa T., Tsao G.S.W., Yao K.M., Chan K.K.L. and Ngan H.Y.S., Loss of MKP3 is associated with cisplatin-resistance and tumorigenicity of ovarian cancer, American Association for Cancer Research. Annual Meeting 2007. Los Angeles, CA, USA. 2007. |
|
Chan K.K.L., Huang F.Y., Tam K.F., Tse K.Y. and Ngan H.Y.S., Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia, American Journal of Gynecology and Obstetrics. 2006, 195: 1282-1286. |
|
Chan K.K.L., Tam K.F. and Ngan H.Y.S., The use of vaginal anti-microbial after large loop excision of transformation zone (LLETZ) - a prospective randomized trial, 11th Biennial Meeting International Gynaecologic Cancer Society, Santa Monica, USA, 14-18 October. 2006. |
|
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
|
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
|
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
|
Creasman W.T., Odicino F., Maisonneuve P., Quinn M.A., Beller U., Benedet J.L., Heintz A.P., Ngan H.Y.S. and Pecorelli S., Carcinoma of the corpus uteri, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S105-143. |
|
Heintz A.P., Odicino F., Maisonneuve P., Quinn M.A., Benedet J.L., Creasman W.T., Ngan H.Y.S., Pecorelli S. and Beller U., Carcinoma of the fallopian tube, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S145-160. |
|
Heintz A.P., Odicino F., Maisonneuve P., Quinn M.A., Benedet J.L., Creasman W.T., Ngan H.Y.S., Pecorelli S. and Beller U., Carcinoma of the ovary, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S161-192. |
|
Khoo
U.S., Liu W., Long J.R., Yip
S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
|
Lee
Y.W., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of
the role of AMPK-γ |
|
Leung G.M., Woo P.S., McGhee S.M., Cheung A.N.Y., Fan S., Mang O., Thach T.Q. and Ngan H.Y.S., Age-period-cohort analysis of cervical cancer incidence in Hong Kong from 1972 to 2001 using maximum likelihood and Bayesian methods, Journal of Epidemiology and Community Health. 2006, 60: 712-720. |
|
Liao X., Xue W.C., Shen D.H., Ngan H.Y.S., Siu K.Y. and Cheung A.N.Y., p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas., Histopathology. 2007, in press. |
|
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
|
Liu V.W.S., Chan D.W. and Ngan H.Y.S., High frequency of promoter hypermethylation of metallothionein 1E in endometrial carcinomas, American Association for Cancer Research. Annual Meeting 2007 Los Angeles, USA. 2007. |
|
Ngan H.Y.S., An overview of the advances in cervical cancer control initiatives, 50th Golden Jubilee, All India Congress of Obstetrics and Gynaecology (AICOG), N.N. Roychowdhury Memorial session on Cervical cancer, January 5-9. 2007. |
|
Ngan H.Y.S., Can cervical cancer be prevented?, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, November 5-10. 2006. |
|
Ngan H.Y.S., Cervical cancer prevention and control, International Faculty in AICOG 2007, Kolkata, India, 5-9 January. 2007. |
|
Ngan H.Y.S., Co-eiitor : Staging Classification and Gynecologic Cancers, FIGO Gynecologic Oncology and International Gynecologic Cancer Society Guidelines Committee, Third Edition, November 2006. 2006. |
|
Ngan H.Y.S., Editorial Boaed Member - Journal of Paediatrics, Gynaecology and Obstetrics 1997. 2006. |
|
Ngan H.Y.S., Editorial Board Member - Gynecologic Oncology 2005. 2006. |
|
Ngan H.Y.S., Editorial Board Member - Hong Kong Journal of Gynaecology, Obstetrics and Midwifery 1998. 2006. |
|
Ngan H.Y.S., Editorial Board Member - International Journal of Gynecologic Cancer 2001. 2006. |
|
Ngan H.Y.S., Editorial Board Member - Journal of Clinical Oncology (Chinese Edition) 2000. 2006. |
|
Ngan H.Y.S., Editorial Board Member - Journal of Obstetrics and Gynaecology Research . 2006. |
|
Ngan H.Y.S., Editorial Board Member - The Hong Kong Medical Journal. 2006. |
|
Ngan H.Y.S., Odicino F., Maisonneuve P., Creasman W.T., Beller U., Quinn M.A., Heintz A.P., Pecorelli S. and Benedet J.L., Gestational trophoblastic neoplasia, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S193-203. |
|
Ngan H.Y.S., Global burden of cervical cancer and screening paradigm, Interim AOGIN Meeting "The new perspectives on HPV and cervical cancer, Seoul, Korea, May 11. 2007. |
|
Ngan H.Y.S., Guest Editor of a book "Clinical Obstetrics and Gynaecology (Bailliere's Best Practice and Research) on "Gestational Trophoblastic Diseases" 2003. 2006. |
|
Ngan H.Y.S., HPV and cervical cancer, As Chair of the Gynecologic Oncology Committee of FIGO, XVIII FIGO Congress, Kuala Lumpur, Malaysia, November 5-10. 2006. |
|
Ngan H.Y.S., HPV vaccine - The Dos and Don'ts, Annual Scientific Meeting Hong Kong Society of Dermatology and Venerology, Hong Kong, June 24. 2007. |
|
Ngan H.Y.S., Morbidities of radical hyterectomy and pelvic lymphadenectomy, "The 16th Annual Review Course on Gynecologic Oncology and Pathology" as "International Symposium on Radical Hysterectomy Dedicated to Hidekazu Okabayashi", Kyoto, Japan, February 6-10. 2007. |
|
Ngan H.Y.S., Multidisciplinary symposium - ca of uterus, cervix and ovary - key points in surgery, Cancer Imaging, Joint Meeting of the International Cancer Imaging Society and Hong Kong College of Radiologists, Hong Kong, February 10-11. 2007. |
|
Ngan H.Y.S., Pre-congress workshop, The theme was on "Impact on Emerging Issue" , WHO/FIGO Alliance for Women's Health, Kuala Lumpur, Malaysia, November 2-3. 2006. |
|
Ngan H.Y.S., Tam K.F., Lam K.W. and Chan K.K.L., Relapsed gestational trophoblastic neoplasia: A 20-year experience, Journal of Reproductive Medicine. 2006, 51(10): 829-834. |
|
Ngan H.Y.S., Report on the use of GTN 2000 staging, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, November 5-10. 2006. |
|
Ngan H.Y.S., Symposium on "Sexually Transmitted Diseases", Annual Scientific Meeting Hong Kong Society of Dermatology and Venerology, Hong Kong, June 24. 2007. |
|
Ngan H.Y.S., The FIGO cercical cancer staging, 11th Biennial Meeting - International Gynecologic Cancer Society (IGCS), Santa Monica, USA, October 14-18. 2006. |
|
Ngan H.Y.S., The FIGO cervix cancer committee: its cervix cancer campaign strategies", Second AOGIN Biennial Conference, Cebu, Philippines, September 8-10. 2006. |
|
Ngan H.Y.S., The role of FIGO staging in management of gynecologic cancers, 8th China Gynecologic Oncology Conference, Shanghai, China, April 24-27. 2007. |
|
Quinn M.A., Benedet J.L., Odicino F., Maisonneuve P., Beller U., Creasman W.T., Heintz A.P., Ngan H.Y.S. and Pecorelli S., Carcinoma of the cervix uteri, International Journal of Gynecology and Obstetrics. 2006, 95 Suppl 1: S43-103. |
|
Siu
K.Y., Woo N.W., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Biological significant of
p21-activated kinase |
|
Tam K.F. and Ngan H.Y.S., A rerview of ovarian cancer screening, Journal of Paediatrics, Obstetrics and Gynaecology. 2006, SEP/OCT: 216-219. |
|
Tam K.F. and Ngan H.Y.S., A short review on human papillomavirus vaccines, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2006, 6(1): 32-36. |
|
Tam K.F., Lam K.W., Chan K.K.L. and Ngan H.Y.S., Detection of pelvic lymphocysts following bilateral pelvic lymphadenectomy using 3-D ultrasonogram, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Tam K.F., Cheung A.N.Y., Liu S., Xue W. and Ngan H.Y.S., Expression of Matrix Metalloproteinases and tissue inhibitors of metalloproteinases in atypical complex endometrial hyperplasia with and without associated malignancy, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
|
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
|
Tam K.F., Ng T.Y., Tsang P.C.K., Li I.C.F. and Ngan H.Y.S., Potential use of the adenosine triphosphate cell viability assay in endometrial cancer, Journal of The Society for Gynecology Investigation. 2006, 13(7): 518-522. |
|
To M.Y., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the role of FOXG1B in the development of ovarian cancer, The 11th Research Postgraduate Symposium 2006, The University of Hong Kong, Hong Kong, 1 Dec. 2006. |
|
Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., 20-year experience of managing profuse bleeding in gestational trophoblastic disease, Journal of Reproductive Medicine. 2007, 52(5): 397-401. |
|
Wang Y., Liu V.W.S., Xue W., Cheung A.N.Y. and Ngan H.Y.S., Association of decreased mitochondrial DNA content with ovarian cancer progression , British Journal of Cancer. 2006, 95: 1087-1097. |
|
Wang Y., Xue W., Liu V.W.S. and Ngan H.Y.S., Detection of Mosaic Pattern of Mitochondrial DNA Alterations in Different Populations of Cells from the Same Endometrial Tumor, Mitochondrion. Elsevier, 2007, 7: 171-175. |
|
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
|
Yang H., Liu V.W.S., Wang Y., Tsang P.C.K. and Ngan H.Y.S., Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data, BMC Cancer. 2006, 6: 212. |
|
Yu Y.M., Liu V.W.S. and Ngan H.Y.S., AMP-activated Protein Kinase Reduced Cervical Cancer Cell Death under Glucose Deprivation, Hong Kong International Cancer Congress, Hong Kong, 15-17 Dec . 2006. |
|
Yu Y.M., Liu V.W.S. and Ngan H.Y.S., Functional analysis of AMPK activity in cervical cancer cells, European Cytokine Network (Volume 17, Supplement August 2006. Cytokines 2006- Vienna). 2006. |
|
Researcher
: Ong CYT |
|
Project Title: |
To determine the correlation of changes in maternal levels of pregnancy-associated plasma protein A (PAPP-A) and free [beta] human chorionic gonadotrophin (F[beta]-hCG) with placental development and fetal outcomes |
|
Investigator(s): |
Ong CYT, Lao TTH, Leung WC, Leung KY, Lam HSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To correlate the serial changes of maternal serum PAPP-A and free [beta]-hCG concentrations with placental volume and vascular indices, swell as fetal size, as assessed by 3-D/4-D ultrasonographic studies throughout pregnancy; to determine whether different patterns in the changes of PAPP-A and free [beta]-hCG in different trimesters will be predictive of different patterns of placental development and fetal growth, and whether this can help to identify specifically the eventual complications through the association with the various growth and developmental patterns. |
|
Project Title: |
Assessment of the interrelationship among the angiogenic growth factors and topological properties of placental villous capillaries with fetal growth, development of the placenta and its vasculature progressively throughout the course of pregnancy, and pregnancy outcomes |
|
Investigator(s): |
Ong CYT |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Incentive Award for RGC CERG Fundable But Not Funded Projects |
|
Start Date: |
07/2004 |
|
Abstract: |
|
N/A |
|
Project Title: |
First trimester prediction of fetal α-thalassaemia-1 with maternal serum markers, nuchal translucency measurement and three dimentional ultrasound measurement of placental volume |
|
Investigator(s): |
Ong CYT, Chen M, Leung KY, Tang MHY, Lee CP |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To measure 3D ultrasound placental and fetal volume at 10-14 weeks of gestation, and to determine whether different changes in the placental volume is predictive of fetuses affected by α-thalassaemia-1; to measure maternal serum PAPP-A and free β-hCG concentrations in fetuses affected and unaffected by β-thalassaemia-1 at 10-14 weeks of gestation, and determine the predictive value of these markers along with or without NT measurement in diagnosis of fetuses affected by α-thalassaemia-1. |
|
Project Title: |
Maternal serum level of ADAM 12 as an early marker of trisomy 21, trisomy 13 and trisomy 18 |
|
Investigator(s): |
Ong CYT, Lee CP, Lau ETK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Objectives 1. To investigate the use of
maternal serum ADAM 12 concentration in the first trimeter as a marker of
trisomy 21, trisomy 18 and trisomy 13. 2. To correlate maternal serum with
pregnancy outcomes Brief background and significance The ADAMs (A disintegrin
and metalloprotease) constitute a glycoprotein family with proteolytic and
cell-adhesion activities (Wolfsberg et al., 1995; Primakoff and Myles, 2000;
Seals and Courtneidge, 2003). Human ADAM12 exists in two forms, ADAM12-L
(long) and ADAM12-S (short), the latter being the secreted form of ADAM12.
ADAM12-S differs from ADAM12-L at the C-terminal end in that it does not
contain the transmembrane and cytoplasmatic domains (Gilpin et al., 1998).
ADAM12-S binds to and has proteolytic activity against insulin-like growth
factor binding protein (IGFBP)-3 and, to a lesser extent, IGFBP-5. Insulin
growth factors (IGFs) I and II are proinsulin-like polypeptides that are
produced in nearly all foetal and adult tissues. Lack of IGF I and II causes
foetal growth retardation in mice (Powel-Braxton et al., 1993). The cleavage
of IGFBPs into smaller fragments with reduced affinity for the IGFs reverses
the inhibitory effects of the IGFBPs on the mitogenic and DNA stimulatory
effects of the IGFs (Blat et al., 1994). ADAM12-S is an important indicator
of foetal growth because ADAM12-S is an IGFBP-3 protease and IGFBP-3 is the
most abundant IGFBP in serum. The proteolysis of IGFBP-3 would stimulate
growth by increasing levels of bioavailable IGF I and II. Previous study
(Laigaard et al. 2003) has reported that in 18 first trimester Down syndrome
pregnancies versus 136 healthy controls, maternal serum concentration of ADAM12
was decreased with the median multiple of mean (MoM) value of 0.14
(0.01-0.76). This results in a detection rate of 82% for a false positive
rate of 3.2% (using 1:400 risk as cut-off) for fetal Down syndrome. In
another study (Laigaard et al. 2005), maternal serum ADAM 12-S concentrations
were found to be lower in trisomy 18 pregnancies than in normal pregnancies,
with a median multiple of the median (MoM) of 0.28 (p < 0.001). These
findings suggest that maternal serum ADAM 12-S may be a novel marker for trisomy
21, trisomy 18 and perhaps trisomy |
|
List of Research Outputs |
|
Ong C.Y.T., Lee C.P., Leung K.Y., Lau E.Y.L. and Tang M.H.Y., Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0 - Thalassemia Pregnancies, Obstetrics and Gynecology. 2006, 108(3), Part 1: 651-655. |
|
Researcher
: Pun TC |
|
List of Research Outputs |
|
Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
|
Leung W.C., Chan C.P., Ma G., Lam K.W., Leung K.Y., Pun T.C., Lao T.T.H. and Lee C.P., Continued reduction in the incidence of birth trauma and birth asphyxia related to instrumental deliveries after the study period: Was this the Hawthorne effect?, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 130: 165-168. |
|
Pun T.C., Vaginal hysterectomies in patients without uterine prolapse : a local perspective, Hong Kong Medical Journal. 2007, 13(1): 27-30. |
|
Researcher
: Tam KF |
|
List of Research Outputs |
|
Tam K.F. and Ngan H.Y.S., A rerview of ovarian cancer screening, Journal of Paediatrics, Obstetrics and Gynaecology. 2006, SEP/OCT: 216-219. |
|
Tam K.F. and Ngan H.Y.S., A short review on human papillomavirus vaccines, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2006, 6(1): 32-36. |
|
Tam K.F., Lam K.W., Chan K.K.L. and Ngan H.Y.S., Detection of pelvic lymphocysts following bilateral pelvic lymphadenectomy using 3-D ultrasonogram, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
|
Tam K.F., Ng T.Y., Tsang P.C.K., Li I.C.F. and Ngan H.Y.S., Potential use of the adenosine triphosphate cell viability assay in endometrial cancer, Journal of The Society for Gynecology Investigation. 2006, 13(7): 518-522. |
|
Tam K.F., Psychosocial intervention in gynaecological oncology, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
|
Researcher
: Tam YT |
|
List of Research Outputs |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Characterization of a novel acrosome-expressing protein 2 (AEP2/VAD1.2) during spermatogenesis, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Spatiotemporal expression of a novel acrosome expressing protein 2 (AEP2/VAD1.2) in spermatogenesis. , XIX North American Testis Workshop; "Chromosome Structure and Gene Expression", Tampa, FL, U.S.A., 18 - 21 April 2007. |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Temporal-spatial expression of a novel acrosome expressing protein 2(AEP2/VAD1.2) in spermatogenesis, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1.3) using conditional gene knockout approach, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1/3) using gene knockout approach. , XIX North American Testis Workshop: “Chromosome Structure and Gene Expression”, 18-21 April, Tampa, FL, USA.. 2007, P.44. |
|
Researcher
: Tang FOS |
|
Project Title: |
A prospective randomized comparison of sublingual and vaginal misoprostol in termination of pregnancy in the second trimester |
|
Investigator(s): |
Tang FOS, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
10/2000 |
|
Abstract: |
|
To compare the efficacy of sublingual and vaginal misoprostol in termination of second trimester pregnancy. |
|
List of Research Outputs |
|
Chan C.C.W., Ng E.H.Y., Tang F.O.S., Lee C.P. and Ho P.C., The prevalence of polycystic ovaries in Chinese women with a history of gestational diabetes mellitus, Gynecological Endocrinology. 2006, 22(9): 516-520. |
|
Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized comparison of side effects and patient convenience between CyclogestÒ suppositories and EndometrinÒ tablets used for luteal phase support in IVF treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 131: 182-188. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26: 931-939. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with live birth following assisted reproduction treatment than in those who suffer a miscarriage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage, Human Reproduction. 2007, 22(4): 1134-1141. |
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Ngai C.S.W., Tang F.O.S. and Ho P.C., Drugs for second trimester termination of pregnancy, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 147-153. |
|
Tang F.O.S. and Ho P.C., Clinical applications of mifepristone , Gynecological Endocrinology. 2006, 22(12): 655-659. |
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Tang F.O.S. and Ho P.C., Drugs used in first trimester termination of pregnancy, In: Edited by W.L.Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 141-146. |
|
Tang F.O.S., Evra TM (Norelgestromin/Ethinylestradiol), Medical Progress. 2006, 33(8): 399-400. |
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Tang F.O.S., Medical abortion: Second trimester, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, 2006, Kuala Lumpur, Malaysia. 2006. |
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Tang F.O.S. and Ho P.C., Mifepristone, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 131-133. |
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Tang F.O.S., Misoprostol an essential drug in Obstetrics and Gynaecology: different routes of administration, The 7th Meeting of the International Federation of Abortion and Contraception Professionals (FIAPAC) "Freedom and Rights in Reproductive Health", 13-14 October, Rome, Italy. 2006. |
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Tang F.O.S. and Ho P.C., Pharmacology of prostaglandins, In: Edited by W.L. Ledger and P.C. Ho, Gynecological Drug Therapy. Informa Healthcare USA, Inc., 2007, 135-140. |
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Tang F.O.S. and Ho P.C., The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion, Contraception. 2006, 74: 26-30. |
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Tang F.O.S., The prevalence of polycystic ovary in Chinese women with a history of gestational diabetes, XVIII FIGO World Congress of Gynecology and Obstetrics, November 5-10, Kuala Lumpur, Malaysia. 2006. |
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Tang F.O.S. and Ho P.C., The use of misoprostol for early pregnancy failure, Current Opinion in Obstetrics and Gynecology. 2006, 18: 581-586. |
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Tang F.O.S., Ultrasound guided embryo transfer, The 20th Anniversary Symposium on IVF, The Reproductive Medicine where we are heading, 11-12 November, Hong Kong. 2006. |
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Tang F.O.S., Ultrasound-guided embryo transfer , The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. 2007. |
|
Researcher
: Tang GWK |
|
Project Title: |
A cross sectional health care study of Chinese perimenopausal women in Hong Kong |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1993 |
|
Abstract: |
|
To study Chinese women in Hong Kong on: 1) their perception and understanding of the menopause; 2) their symptoms expressed and experienced before, during and after the menopause; 3) bone density in various age groups ranging from adolescence to postmenopause and to correlate such values with biophysical parameters and diet; 4) how best health care strategies can be planned based on the findings in the study so that women's needs are met most cost effectively. |
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Project Title: |
Fracture incidence reduction and safety of TSE-424 (Bazedoxifene Acetate) compared to placebo and Raloxifene in osteoporotic postmenopausal women / Endomentrial Safety Substudy |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Wyeth Austral PTY Ltd - General Award |
|
Start Date: |
02/2002 |
|
Abstract: |
|
(A) This reduction in the circulating levels of oestrogen during menopause is associated with a number of changes, including osteoporosis. Osteoporosis is characterized by a loss of bone mass and micro architectural deteroration of bones tissue, with a consequent increase in bone fragility and susceptibility to bone fracture. (B) Bazedoxifene acetate is a selective oestrogen receptor modulator (SERM). It has been designed to exhibit the positive effects of an oestrogen agonist on the skeletal and cardiovascular systems, while acting as an antagonist on the uterus and the breast. SERMs have 2 principal indications in the clinic: the prevenetion and treatment of postmenopausal osteoporsis(raloxifene) and the prevention and treatment of breast cancer (tamoxifen), mainly in postmenopausal women. (C) Pre-clinical studies suggest that bazedoxifene acetate protects bone at a lower dose than currently marketed SERMs with no uterine agonist effect, a low potentional to induce flushes, and an improvement in the serum lipid profile. Pre-clinical data has also demonstrated that bazedoxifene acetate effectively suppress the proliferation of breast cancer cell lines, which suggests that it may exhibit antagonist activity on breast cell proliferation. (D) This is a multi-centre, double-blind, randomised, placebo and active comparator controlled phase 3 trial that will involve approximately four thousand patients. There will be about 180 sites participating in the study, which will be conducted globally. Of the four thousand patients recrutied into the study, 1000 patients will be recruited to one of the following four study groups: 1. bazedoxifence acetate 20mg, 2. bazedoxifence acetate 40mg, 3. raloxifece 60mg, 4. placebo. |
|
Project Title: |
Main Study (013-01)- A study to Evaluate the Efficacy of Quadrivalent HPV (Types 6,11,16 and 18) L1 Virus-Like Particle (VLP) Vaccine in Reducing the Incidence of HPV 6/11-, 16- and 18- Related CIN, and HPV 16 and 18-Related AIS and Cervical Cancer, and HPV 6/11-, 16-, and 18-Related External Genital Warts, VIN and VaIN, and HPV 16 and 18-Related Vulvar and Vaginal Cancer in 16- to 23- Year-Old Women -- The F.U.T.U.R.E. I Study (Females United to Unilaterally Reduce Endo/Ectocervical disease). Substudy (012-01)- Immunogenicity and Safety of Quadrivalent HPV (Types 6,11,16,18)L1 Virus-Like Particle (VLP) Vaccine in 16- to 23-Year-Old Women With an Immunogenicity Bridge Between the HPV 16 Component of the Qualdrivalent Vaccine and the Monovalent HPV 16 Vaccine Pilot Manufacturing Material - The F.U.T.U.R.E. I Study (Females United to Unilaterally Reduce Endo/Ectocervical Disease) |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Merck, Sharp and Dohme (Asia) Ltd. - General Award |
|
Start Date: |
08/2002 |
|
Abstract: |
|
To demonstrate that a 3-dose regimen of quadrivalent HPV (Types 6,11,16,18) L1 VLP vaccine is generally well tolerated; to demonstrate that quadrivalent HPV vaccine is generally well tolerated. |
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List of Research Outputs |
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Garland S.M., Hernandez-Avila M., Wheeler C.M., Perez G., Harper D.M., Leodolter S., Tang G.W.K., Ferris D.G., Steben M., Bryan J., Taddeo F.J., Railkar R., Esser M.T., Sings H.L., Nelson M., Boslego J., Sattler C., Barr E. and Koutsky L.A., Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases, The New England Journal of Medicine. 2007, 356(19): 1928-1943. |
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Joura E.A., Leodolter S., Hernnandez-Avila M., Wheeler C.M., Perez G., Koutsky L.A., Garland S.M., Harper D.M., Tang G.W.K., Ferris D.G., Steben M., Jones R.W., Bryan J., Taddeo F.J., Bautista O.M., Esser M.T., Sings H.L., Nelson M., Boslego J.W., Sattler C., Barr E. and Paavonen J., Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three clinical trials, The Lancet. 2007, 369: 1693-1702. |
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Tang G.W.K., Quality Assurance of Postgratduate Medical Education, 4th Asian Pacific Medical Education Conference, Singapore. 2007. |
|
Researcher
: Tang MHY |
|
List of Research Outputs |
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Chen M., Lee C.P., Lam Y.H., Chan S.M. and Tang M.H.Y., Chinese fetal renal pelvis measurements at 12-14 weeks of gestation, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, 25-28 February, 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P. and Tang M.H.Y., Cystic hygroma detected in the first trimester scan, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., Lam Y.H., Lee C.P., Tang R., Chan C.P., Wong S.F., Tse H.Y. and Tang M.H.Y., Effect of first trimester ultrasound screening on perinatal outcome, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chen M., Lee C.P., Tang R., Chan B., Ou C.Q. and Tang M.H.Y., First-trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2006, 26(8): 703-706. |
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Chen M., Lee C.P., Lam Y.H., Ou C. and Tang M.H.Y., First-trimester fetal limb biometry in Chinese population, Prenatal Diagnosis. 2007, 27: 133-138. |
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Chen M., Lee C.P. and Tang M.H.Y., First-trimester fetal limb biometry in the Chinese population, In: Comments by Dr. Mahmut Tuncay Ozgun for Article (Chen et al., Prenatal Diagnosis 2007; 27:133-138) , Prenatal Diagnosis. 2007, 27: 587. |
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Chen M., Lam Y.H., Ma E.S.K., Wong K.Y. and Tang M.H.Y., Intrauterine therapy in a fetus with severe congenital dyserythropoietic anaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Chow P.C., Lee S.L., Tang M.H.Y., Chan K.L., Lee C.P., Lam B.C.C. and Tsoi N.S., Management and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung, Hong Kong Medical Journal. 2007, 13(1): 31-39. |
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Hui P.W., Leung K.Y., Lau E.T.K. and Tang M.H.Y., Confined placental mosaicism of trisomy 16 presenting with placental mass and intrauterine death, The 3rd International Scientific Meeting of the International Society of Ultrasound in Obstetrics & Gynaecology. 25-28 February 2007, Hong Kong. 2007. |
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Hui P.W., Chen M., Ng E.H.Y., Tang F.O.S., Leung W.C., Chan C.P., Lao T.T.H., Tang M.H.Y. and Ho P.C., First Trimester Growth in Fetuses from Assisted Reproduction and Spontaneous Pregnancies , The 16th World Congress on Ultrasound in Obstetrics and Gynecology, London, United Kingdom, 3-7 Sept. 2006. |
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Leung K.Y., Liao C., Ma S.Y., Chen M., Lee C.P., Lam Y.H. and Tang M.H.Y., 2D and 3D ultrasound prediction of homozygous a thalassemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung K.Y., Liao C., Li Q.M., Tang M.H.Y., Lee C.P., Lam Y.H. and Chan V.N.Y., A Non-invasive Approach To Prenatal Diagnosis Of Homozygous ao Thalassemia, XVIII FIGO World Congress of Gnecology and Obstetrics in Kuala Lupmur, Malaysia, 5-10th November 2006. |
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Leung K.Y., Liao C., Li Q.M., Ma S.Y., Tang M.H.Y., Lee C.P., Chan V.N.Y. and Lam Y.H., A new strategy for prenatal diagnosis of homozygous a0-thalassemia, Ultrasound Obstetrics and Gynecology. 2006, 28: 173-177. |
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Leung K.Y., Yin A., Hui P.W., Lee C.P. and Tang M.H.Y., Prenatal Screening for Down Syndrome, JPOG. 2007, 33: 80 - 87. |
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Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Comparison of 2D and 3D multi-planar ultrasonography in the prediction of alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung T.W., Leung K.Y., Chen M., Lee C.P. and Tang M.H.Y., Use of 2D and 3D ultrasound to study the growth of fetuses affected by homozygous alpha thalassaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Leung W.C., Chen M., Lau E.T.K., Lao T.T.H. and Tang M.H.Y., Application of rapid aneuploidy detection versus karyotyping in prenatal diagnosis, 產前診斷中常見染色體異常的快速檢測與核型分析技術的應用, Chinese Journal of Obstetrics and Gynecology. (中華婦產科雜志), 2007, 42(5): 348-350. |
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Li T.K.T., Leung K.Y., Lee Y.P., Chan H.Y., Lee C.P. and Tang M.H.Y., Risk of fetal abnormalities after intake of herbal medicinal products and western pharmaceutical products, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
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Ong C.Y.T., Lee C.P., Leung K.Y., Lau E.Y.L. and Tang M.H.Y., Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0 - Thalassemia Pregnancies, Obstetrics and Gynecology. 2006, 108(3), Part 1: 651-655. |
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Wang L.M., Leung K.Y. and Tang M.H.Y., Prenatal evaluation of facial clefts by three-dimensional extended imaging, Prenatal Diagnosis. 2007, 27: 722-729. |
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Wang L.M., Leung K.Y., Lee C.P. and Tang M.H.Y., Prenatal evaluation of facial clefts by three-dimensional extended imaging, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
|
Researcher
: To MY |
|
List of Research Outputs |
|
To M.Y., Liu V.W.S., Chan D.W. and Ngan H.Y.S., The investigation of the role of FOXG1B in the development of ovarian cancer, The 11th Research Postgraduate Symposium 2006, The University of Hong Kong, Hong Kong, 1 Dec. 2006. |
|
Researcher
: Tsang PCK |
|
List of Research Outputs |
|
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
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Tam K.F., Ng T.Y., Tsang P.C.K., Li I.C.F. and Ngan H.Y.S., Potential use of the adenosine triphosphate cell viability assay in endometrial cancer, Journal of The Society for Gynecology Investigation. 2006, 13(7): 518-522. |
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Yang H., Liu V.W.S., Wang Y., Tsang P.C.K. and Ngan H.Y.S., Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data, BMC Cancer. 2006, 6: 212. |
|
Researcher
: Tse PK |
|
List of Research Outputs |
|
Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
|
Lee
C.Y.L., Tse P.K., Chow W.N., Lee C.K.F. and Yeung W.S.B., Hormonal regulation and
convertase activities of complement |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Wang Y., Xue W., Liu V.W.S. and Ngan H.Y.S., Detection of Mosaic Pattern of Mitochondrial DNA Alterations in Different Populations of Cells from the Same Endometrial Tumor, Mitochondrion. Elsevier, 2007, 7: 171-175. |
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Yang H., Liu V.W.S., Wang Y., Tsang P.C.K. and Ngan H.Y.S., Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data, BMC Cancer. 2006, 6: 212. |
|
Researcher
: Wong BPC |
|
List of Research Outputs |
|
Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
|
Researcher
: Wong ST |
|
List of Research Outputs |
|
Wong S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Researcher
: Yang H |
|
List of Research Outputs |
|
Yang H., Liu V.W.S., Wang Y., Tsang P.C.K. and Ngan H.Y.S., Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data, BMC Cancer. 2006, 6: 212. |
|
Researcher
: Yeung WSB |
|
Project Title: |
Functional studies of VCY2 and VCY2 interacting protein (VCY2IP-1) |
|
Investigator(s): |
Yeung WSB, Tam PC, Tse JYM, Huang J |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Incentive Award for RGC CERG Fundable But Not Funded Projects |
|
Start Date: |
07/2003 |
|
Abstract: |
|
N/A |
|
Project Title: |
The mechanisms of action of glycodelin-A on zona pellucida induced acrosome reaction |
|
Investigator(s): |
Yeung WSB, Chiu CN, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Glycodelin is a glycoprotein belonging to the lipocalin family. It has 3 reported isoforms; namely amniotic fluid-derived glycodelin-A, seminal plasma-derived glycodelin-S and follicular fluid-derived glycodelin-F (Seppala et al., 2002; Chiu et al., 2003). The isoforms of glycodelin have the same protein core but differ in their glycosylation. Glycodelin-A is the first endogenous glycoprotein found to inhibit spermatozoa-zona pellucida binding (Oehninger et al., 1995). Its absence in the endometrium in the periovulatory period may be related to the presence of a fertilization window (Seppala et al., 1998). Glycodelin-A is produced by the oviduct tissue and is also present in the follicular fluid (Chiu PCN and Yeung WSB, unpublished data). Thus the spermatozoa are likely to come in contact with glycodelin-A in the oviduct before they meet the oocyte. We hypothesize that glycodelin-A has effects on spermatozoa other than its action on spermatozoa-zona pellucida interaction. Indeed, our preliminary data show that glycodelin-A stimulates zona-pellucida-induced acrosome reaction of human spermatozoa, though the molecule does not affect spontaneous acrosome reaction. Acrosome reaction is a critical event in fertilization and is induced by the zona pellucida of oocyte. It allows the spermatozoa to release acrosomal enzymes, and thereby facilitating the penetration of the spermatozoa through the zona pellucida. Our observation suggests that glycodelin-A primes the spermatozoa for this important event of fertilization. The objective of this proposal is to study the intracellular mechanisms in human spermatozoa leading to the priming action of glycodelin-A on zona pellucida-induced acrosome reaction. A priming effect of progesterone on acrosome reaction had been reported in mouse (Roldan et al., 1994) and guinea-pig (Shi et al. 2005) and is regulated by intracellular calcium concentration, phospholipase and/or cAMP/PKA pathway. References Chiu PCN, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB (2003) Biol Reprod, 69, 365-72. Oehninger S, Coddington CC, Hodgen GD, Seppala M (1995) Fertil Steril, 63, 377-83. Oehninger S, Franken DR, Sayed E, Barroso G, Kolm P (2000) Hum Reprod Update 6, 160-8. Seppala M, Taylor RN, Koistinen H, Koistinen R, Milgrom E (2002) Endocr Rev 23, 401-430.. Seppala M, Koistinen H, Koistinen R, Mandelin E, Oehninger S, Clark GF, Dell A, Morris HR. (1998) Hum Reprod 13 (suppl 3), 262-70. Roldan ER, Murase T, Shi QX (1994) Science, 266(5190), 1578-81. Shi QX, Chen WY, Yuan YY, Mao LZ, Yu SQ, Chen AJ, Ni Y, Roldan ER (2005) J Cell Physiol.[Epub ahead of print]. |
|
Project Title: |
The mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding |
|
Investigator(s): |
Yeung WSB, Chiu CN, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To determine the effect of glycodelin-C treatment on zona pellucida protein binding; to determine the intracellular signalling pathway of glycodelin-C in human spermatozoa; to study the mechanisms of action of glycodelin-C in increasing spermatozoa-zona binding. |
|
Project Title: |
Glycodelin-A binds to and protects human spermatozoa from T-lymphocyte attack |
|
Investigator(s): |
Yeung WSB, Chiu CN |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
The female reproductive tract is fully
capable of cell-mediated and humoral immune responses (Metafora et al.,
1989). Spermatozoa express differentiation and histocompatibility antigens on
their surface (Martin-Villa et al., 1999) and induces leukocytic reaction in
the cervical mucus after insemination leading to massive leukocyte
infiltration comprising of polymorphonuclear cells, lymphocytes and
macrophages (Thompson et al., 1992). However, this immunologic sensitization
of the female to sperm antigens does not lead to immunologic damage of
spermatozoa. The mechanism of sperm immunoprotection within the female
reproductive tract is not well understood (Barratt and Pockley, 1998). One
possible mechanism is the presence of molecules in the female reproductive
tract that inhibit the immune response or mask the sperm antigenic
determinants recognized by the female's immune system. Glycodelin is a
lipocalin glycoprotein with three well-known isoforms, namely glycodelin-A
(amniotic fluid isoform), glycodelin-S (seminal plasma isoform) and
glycodelin-F (follicular fluid isoform) (Seppala et al., 2002; Yeung et al.,
2006). They have the same protein core but with different glycosylation. The
most well accepted biological function of glycodelin-A is on immunosuppression.
Glycodelin-A inhibits T cell proliferation (Rachmilewitz et al., 1999),
induces apoptosis in T cells (Mukhopadhyay et al., 2001) and decreases
synthesis of interleukin (IL)-2 and soluble IL-2 receptor (Pockley and
Bolton, 1989). Glycodelin-A also renders T cells less sensitive to
stimulation (Rachmilewitz et al., 2001) which is mediated by the tyrosine
phosphatase receptor CD45 on T cell surfaces (Rachmilewitz et al., 2003).
Furthermore, glycodelin-S in the seminal plasma exhibited in vitro immunosuppressive
activity, which can be removed by treatment with a monoclonal anti-PP14
antibody-based immunoadsorbent (Bolton et al., 1987). The immunosuppressive
activities of glycodelin-F is still unknown. Glycodelin-A, -F and -S binds to
the acrosome region of human spermatozoa (Chiu et al., 2003) and is present
in the reproductive tract (Seppala et al., 2002; Yeung et al., 2006) through
which the spermatozoa must pass before fertilizing the oocyte. We hypothesize
that glycodelin-A protects the spermatozoa from lymphocyte attack by binding
on the spermatozoa with their carbohydrate moieties. There are 3 objectives
in this project. They are 1. To study the effect of glycodelin pretreatment
on sperm-mediated stimulation of T-lymphocyte. 2. To determine the mechanism(s)
of immunoprotection of glycodelin on spermatozoa 3. To study the role of CD |
|
List of Research Outputs |
|
Chan V.N.Y., Ng E.H.Y., Yam I.Y.L., Yeung W.S.B., Ho P.C. and Chan T.K., Experience in preimplantation genetic diagnosis for exclusion of homozygous ao thalassaemia, Prenatal Diagnosis. 2006, 26: 1029-1036. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Cumulus Oophorus-associated Glycodelin-C displaces sperm-bound Glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding, The Journal of Biological Chemistry. 2007, 282(8): 5378-5388. |
|
Chiu C.N., Chung M.K., Koistinen R., Koistinen H., Seppala M., Ho P.C., Ng E.H.Y., Lee C.K.F. and Yeung W.S.B., Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding, Journal of Cell Science. The Company of Biologists 2007, 2007, 120(1): 33-44. |
|
Chow W.N., Lee C.Y.L., Wong B.P.C., Tse P.K., Chung M.K., Lee C.K.F. and Yeung W.S.B., Complement-3 (C3) expression and fertility study in mice, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Chow
W.N., Lee C.Y.L., Wong B.P.C., Chung M.K., Tse P.K., Lee C.K.F. and Yeung W.S.B., Fertility study of
complement |
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Lee C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., A transcriptomic approach to understand endometrial responses to hormone stimulation in IVF patients. , Xian Symposium 2006 on Reproductive Medicine. Sep 16-17, Xian, China.. 2006. |
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Lee C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF cycles on global endometrial gene expression and receptivity. , The 1st CSRM/CSRB Conjoint Annual Meeting. Hangzhou, China.. 2007. |
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Lee C.K.F., Liu Y., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Effect of stimulated IVF cycles on global endometrial gene expression and receptivity., The 1st CSRM/CSRB Conjoint Annual Meeting. 7-9 April, Hangzhou, China.. 2007, P.204. |
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Lee C.K.F., Ng P.Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Expression of olfactomedin (OLFM) isoforms in human endometrium. , Society for the Study of Reproduction -39th Annual Meeting. Jul 29-Aug 1, Omaha, Nebraska, USA.. 2006, P.350. |
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Lee C.K.F. and Yeung W.S.B., Gamete/embryo - oviduct interactions: implications on in vitro culture., Hum Fertil (Camb). 2006, 9: 137-43. |
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Lee C.K.F., Liu Y., Ng E.H.Y., Ho P.C. and Yeung W.S.B., Global gene expression profiling and endometrial receptivity. , XVIII FIGO World Congress of Gynecology and Obstetrics. Kuala Lumpur, Malaysia.. 2006. |
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Lee C.Y.L., Liu Y., Lee C.K.F., Ng E.H.Y. and Yeung W.S.B., Aberrant angiopoietins 1 to 2 and angiopoietin 2 to VEGF ratio in endometrium of excessive ovarian responders during in vitro fertilization treatment, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
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Lee
C.Y.L., Tse P.K., Chow W.N., Lee C.K.F. and Yeung W.S.B., Hormonal regulation and
convertase activities of complement |
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Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
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Lee P.Y., Yeung W.S.B. and Luk J.M.C., Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction, Frontiers In Bioscience. 2007, 12: 1552-1562. |
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Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
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Mönkkönen K.S., Aflatoonian R., Lee C.K.F., Yeung W.S.B., Tsao G.S.W., Laitinen J.T., Tuckerman
E.M., Li T.C. and Fazeli A., Localization and variable expression of Galphai |
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Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Chan C.C.W., Tang F.O.S. and Ho P.C., A randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with live birth following assisted reproduction treatment than in those who suffer a miscarriage, XIX World Congress on Fertility and Sterility, International Federation of Fertility Societies, April 29-May 3, 2007, Durban, South Africa. 2007. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage, Human Reproduction. 2007, 22(4): 1134-1141. |
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Ng E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Management of male subfertility, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, Jan/Feb 2007: 37-43. |
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Ng E.H.Y., Yeung W.S.B. and Ho P.C., Patients with three or less dominant follicles may not be associated with reduced pregnancy rate of in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2006, 129: 54-59. |
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Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Regulation of olfactomedin isoform expressions in human endometrium, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
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Ng P.P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Roles of olfactomedin isoforms on human endometrial receptivity, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Seppala M., Koistinen H., Koistinen R., Chiu C.N. and Yeung W.S.B., Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations, Human Reproduction Update. 2007, 13: 275-287. |
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Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Characterization of a novel acrosome-expressing protein 2 (AEP2/VAD1.2) during spermatogenesis, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
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Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Spatiotemporal expression of a novel acrosome expressing protein 2 (AEP2/VAD1.2) in spermatogenesis. , XIX North American Testis Workshop; "Chromosome Structure and Gene Expression", Tampa, FL, U.S.A., 18 - 21 April 2007. |
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Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Temporal-spatial expression of a novel acrosome expressing protein 2(AEP2/VAD1.2) in spermatogenesis, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Wong S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
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Yeung W.S.B., Lee C.K.F. and Lee C.Y.L., Embryo culture. , XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
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Yeung W.S.B., An update on glycodelin research - its implication in reproductive medicine, Presented in 100th Anniversary Symposium of Jinan University, Guangzhou, China, November 2006. |
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Yeung W.S.B., Chiu C.N. and Lee C.K.F., An update on glycodelin-research-its implication in reproductive medicine. , The 1st Chinese Society of Reproductive Medicine/Chinese Society of Reproductive Biology Conjoint Annual Meeting. Hangzhou, China.. 2007, 203-204. |
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Yeung W.S.B., Chiu C.N., Lee C.K.F., Seppala M., Koistinen R. and Koistinen H., Glycodelin as a modulator of sperm function, Xi'an Symposium 2006 on Reproductive Medicine. Sep 16-17, Xi'an, China. 2006, 10-11. |
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Yeung W.S.B., Lee C.K.F., Koistinen R., Koistinen H., Seppala M., Ho P.C. and Chiu C.N., Glycodelin: a molecule with multi-functions on spermatozoa., Soc Reprod Fertil Suppl. 2007, 63: 143-51. |
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Yeung W.S.B. and Chow J.F.C., New development in preimplantation genetic diagnosis, XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia.. 2006. |
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Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The identification of a zona pellucida binding protein in human spermatozoa., XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
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Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., The regulation of sperm fertilizing capacity by glycodelin, XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lumpur, Malaysia. 2006. |
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Zeng H., Ren Z., Yeung W.S.B., Shu Y., Xu Y., Zhuang G. and Liang X., Low mitochondrial DNA and ATP contents contribute to the absence of birefringent spindle imaged with PolScope in in vitro matured human oocytes, Human Reproduction. 2007, 22(6): 1681-1686. |
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Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1.3) using conditional gene knockout approach, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
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Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1/3) using gene knockout approach. , XIX North American Testis Workshop: “Chromosome Structure and Gene Expression”, 18-21 April, Tampa, FL, USA.. 2007, P.44. |
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Researcher
: Yin A |
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List of Research Outputs |
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Leung K.Y., Yin A., Hui P.W., Lee C.P. and Tang M.H.Y., Prenatal Screening for Down Syndrome, JPOG. 2007, 33: 80 - 87. |
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Researcher
: Yip MW |
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List of Research Outputs |
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Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
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Researcher
: Yu YM |
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List of Research Outputs |
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Yu Y.M., Liu V.W.S. and Ngan H.Y.S., AMP-activated Protein Kinase Reduced Cervical Cancer Cell Death under Glucose Deprivation, Hong Kong International Cancer Congress, Hong Kong, 15-17 Dec . 2006. |
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Yu Y.M., Liu V.W.S. and Ngan H.Y.S., Functional analysis of AMPK activity in cervical cancer cells, European Cytokine Network (Volume 17, Supplement August 2006. Cytokines 2006- Vienna). 2006. |
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Researcher
: Zuo Y |
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List of Research Outputs |
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Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Characterization of a novel acrosome-expressing protein 2 (AEP2/VAD1.2) during spermatogenesis, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Spatiotemporal expression of a novel acrosome expressing protein 2 (AEP2/VAD1.2) in spermatogenesis. , XIX North American Testis Workshop; "Chromosome Structure and Gene Expression", Tampa, FL, U.S.A., 18 - 21 April 2007. |
|
Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Temporal-spatial expression of a novel acrosome expressing protein 2(AEP2/VAD1.2) in spermatogenesis, Frontiers in Biomedical Research, HKU 2006, The University of Hong Kong, December 7, 2006. |
|
Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1.3) using conditional gene knockout approach, Forth International Huaxia Congress of Endocrinology, December 15-18, 2006, Hong Kong. 2006. |
|
Zuo Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional study of a novel acrosome-specific gene (AEP1/VAD1/3) using gene knockout approach. , XIX North American Testis Workshop: “Chromosome Structure and Gene Expression”, 18-21 April, Tampa, FL, USA.. 2007, P.44. |
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