DEPT OF MICROBIOLOGY
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Researcher
: Bahl J |
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List of Research Outputs |
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Bahl
J., Dhanasekaran
V., Smith G.J., Webster R.G. and Guan Y., Evolutionary dynamics of avian
influenza A virus in the natural reservoir, Options for the control of
influenza VI, |
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Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
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Researcher
: Cai J |
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List of Research Outputs |
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Cai J., Woo P.C.Y., Lau S.K.P., Smith D.K. and Yuen K.Y., Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota., Journal of molecular evolution. 2006, 63(1): 1-11. |
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Researcher
: Cao K |
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List of Research Outputs |
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Chan C.P., Choi W.Y.J., Cao K., Wang M., Gao Y., Zhou D.H., Di B., Xu H.F., Leung M.F., Bergmann A., Lehmann M., Nie Y.M., Cautherley G.W., Fuchs D., Renneberg R. and Zheng B., Detection of serum neopterin for early assessment of dengue virus infection., Journal of Infection. 2006, 53(3): 152-158. |
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Researcher
: Chan CS |
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List of Research Outputs |
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Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
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Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
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Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
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Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
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Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
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Researcher
: Chan KCW |
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List of Research Outputs |
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Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
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Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
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Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
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Researcher
: Chan KH |
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List of Research Outputs |
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Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
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Che X.Y., Di B., Zhao G.P., Wang Y.D., Qiu L.W., Hao W., Wang M., Qin P.Z., Liu Y.F., Chan K.H., Cheng V.C.C. and Yuen K.Y., A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China. , Clinical infectious diseases. 2006, 43(1): e1-e5. |
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Chiang A.K.S. and Chan K.H., Comparison of Serological and Virological Parameters Between Infectious Mononucleosis and Asymptomatic Primary Epstein-Barr Virus Infection, 12th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases (EBV 2006), Boston, USA, 8-12 July 2006. |
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Chiu S.S.S., Peiris J.S.M., Chan K.H., Wong W.H.S. and Lau Y.L., Immunogenicity and Safety of Intradermal Influenza Immunization at a Reduced Dose in Healthy Children, Pediatrics. 2007, 119: 1076-1082. |
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Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
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Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
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Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
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Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen D.P.H., Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L.M., Lim W.W.L., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris J.S.M. and Uyeki T.M., New England Medical Journal, Three Indonesian clusters of h5N1 virus infection in 2005. 2007, 356(13): 1375. |
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Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
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Wong A.S.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Kwong Y.L. and Leung A.Y.H., Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation, Clinical Infectious Disease. 2007, 44(6): 830-837. |
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Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
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Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
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Xu X., Woo G.K.S., Chan K.H. and Chiang A.K.S., Characterization of EBV-specific CD8+ CTL Responses in Childhood Infectious Mononucleosis, 11th Research Postgraduate Symposium, Hong Kong, 7 December 2006. 158. |
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Xu X., Woo G.K.S., Chan K.H. and Chiang A.K.S., Longitudinal study of EBV-specific CD8+ CTL responses in childhood infectious mononucleosis, The Hong Kong Pediatric Society and Hong Kong Paediatric Nurses Association Ltd. - A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, QEH, Hong Kong, 25 November 2006. 43. |
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Yip C.W., Hon C.C., Zeng F., Chow Y.C.K., Chan K.H., Peiris J.S.M. and Leung F.C.C., Naturally Occurring Anti-Escherichia coli Protein Antibodies in the Sera of Healthy Humans Cause Analytical Interference in a Recombinant Nucleocapsid Protein-Based Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Severe Acute Respiratory Syndrome, Clinical and Vaccine Immunology. 2007, 14: 99-101. |
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Zeng F., Hon C.C., Yip C.W., Law K.M., Yeung Y.S., Chan K.H., Peiris J.S.M. and Leung F.C.C., Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: Implications for the functional roles of S2 subunit, Federation of European Biochemical Societies. 2006, 580: 5612-5620. |
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Researcher
: Chan KM |
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List of Research Outputs |
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Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
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Researcher
: Chan MCW |
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Project Title: |
Primary human lung epithelial cells as an in-vitro model to study the pathogenesis of SARS coronavirus infection |
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Investigator(s): |
Chan MCW, Peiris JSM, Tsao GSW |
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Department: |
Microbiology |
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Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
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Start Date: |
01/2006 |
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Abstract: |
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The research objective is to define cytokine, chemokine, SARS functional receptor gene ACE2 and apoptotic related gene expression profile of human lung epithelial cells in response to infection with infectious and inactivated SARS coronavirus and purified viral proteins. |
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Project Title: |
Replication and pathogenesis of avian influenza A (H5N1) viruses in polarized human bronchial and alveolar epithelium |
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Investigator(s): |
Chan MCW, Tsao GSW, Peiris JSM |
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Department: |
Microbiology |
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Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
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Start Date: |
03/2007 |
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Abstract: |
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To establish a well differentiated and polarized primary human respiratory epithelial cell model in vitro to study and compare the replication kinetics of avian influenza H5N1 and H1N1 viruses. This model will provide insights into the pathogenesis of H5N1 disease in the lung. The role of innate immune response mediators and molecules such as mucin, collectins and glycoprotein-340 on viral replication will be investigated. The Contribution of different avian or human influenza viral genes to the viral replication and cytokine induction will be defined using recombinant influenza viruses generated by reverse genetics. |
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List of Research Outputs |
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Chan M.C.W., ASV Postdoctoral Fellow Travel Award, American Society for Virology . 2006. |
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Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
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Chan M.C.W., Promising Junior Investigator Scholarship , Options for the Control of Influenza VI . 2007. |
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Chan M.C.W., Chan W.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., The replication and pathogenicity of influenza A (H5N1) viruses infection in polarized human respiratory epithelium, The American Society For Virology, 25th Annual Meeting. 2006. |
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Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
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Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
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List of Research Outputs |
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Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
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Chan M.C.W., Chan W.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., The replication and pathogenicity of influenza A (H5N1) viruses infection in polarized human respiratory epithelium, The American Society For Virology, 25th Annual Meeting. 2006. |
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Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
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Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
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Researcher
: Chen H |
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Project Title: |
Modification of cells for isolation and characterization of SARS CoV from animal sources |
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Investigator(s): |
Chen H |
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Department: |
Microbiology |
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Source(s) of Funding: |
Seed Funding for New Staff |
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Start Date: |
07/2004 |
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Abstract: |
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To provide: (1) a panel of cell lines (pools) for the isolation of SARS CoV from animal sources; (2) information on molecular mechanism of interspecies transmission of SARS CoV; (3) clues for the further molecular virology studies on this virus. |
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Project Title: |
Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV |
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Investigator(s): |
Chen H, Guan Y |
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Department: |
Microbiology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2004 |
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Abstract: |
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This study will serve as a pilot investigating the potential effect of insertion/deletion on expression of viral proteins down stream of this region and provide clues for further investigation into the molecular mechanism for SARS coronavirus interspecies transmission. |
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Project Title: |
Identification
of the possible animal reservoirs for SARS-like coronavirus in southern |
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Investigator(s): |
Chen H, Guan Y |
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Department: |
Microbiology |
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Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
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Start Date: |
01/2006 |
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Abstract: |
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Even though the SARS epidemic had been brought under control, the lack of understanding of the origin of SCoV make it impossible to determine wheter this disease might come back in future. The detection of SCoV-like virus in wild animal species in Guangdone raises the necessity of furhter understanding the epidemiology and ecology of SCoV or SCoV-like viruses. The objectives of this proposal 1) to identify the animal reservoirs of SCoV-like viruses; 2) to identify the susceptible species that could facilitate the SARS outbreak. 3) to establish a system for the detection and isolation of sCoV-like viruses. The findings generated by this project are of critical importance for scientific and public health points of view, and may provide clues how to prevent the re-emergence of SARS in humans. |
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Project Title: |
Molecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z |
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Investigator(s): |
Chen H, Guan Y |
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Department: |
Microbiology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2006 |
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Abstract: |
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To extend our current genetic and
surveillance studies to investigate the molecular basis for the genesis of
the dominant genotype Z and identify molecular determinants for the
pathogenesis of H5N1 viruses, especially the potential for adaptation of H5N |
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Project Title: |
Antiviral drug resistance in H5N1 virus |
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Investigator(s): |
Chen H, Guan Y |
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Department: |
Microbiology |
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Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
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Start Date: |
01/2007 |
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Abstract: |
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To investigate the geographical distribution of resistance mutations to amantadine and rimantadine in H5N1 isolates from different regions, and to explore if low frequency naturally occuring mutations associated with resistance to oseltamivir are present in H5N1 isolates and if they may contribute to the emergence of oseltamivir resistant strains following exposure to this drug. |
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Project Title: |
H5N1 virus heterogeneity and mechanisms for adaptation to new hosts |
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Investigator(s): |
Chen H, Guan Y |
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Department: |
Microbiology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2007 |
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Abstract: |
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To investigate the distribution of L26I and S31N M2 mutants and H274Y NA mutants among H5N1 isolates from different geographical locations isolated at different points in time; to compare the growth and transmissibility phenotypes of mutants with wild type virus in different hosts, particularly chickens and mice; to study the growth advantage/disadvantage of M2 and NA H5N1 virus mutants in their new hosts, which will provide information on whether such mutants have the potential to gradually increase their presence and/or outgrow wild type virus to become the dominant population; to study the biological fitness of viruses carrying M2 or NA mutations in mammals and explore the pandemic potential of H5N1 virus. |
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List of Research Outputs |
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Bermejo-Martin J.F., Kelvin D.J., Guan Y., Chen H., Perez-Breña P., |
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Boltz D.A., Douangngeun D., Sinthasak S., Phommachanh P., Rolston S., Chen H., Guan Y., Peiris J.S.M., Smith G.J. and Webster R.G., H5N1 influenza viruses in Lao People’s Democratic Republic, Emerging Infectious Diseases. 2006, 12: 1593-1595. |
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Chen
H., 1) A rapid detection assay for H |
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Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
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Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
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Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
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Guan
Y., Zhong N.S., Chen H., Smith G.J. and Zheng B., An averted SARS outbreak, In:
JCK Chan, VCW Taam Wong, Challenges of Severe Acute Respiratory Syndrome.
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Guan Y., Field H., Smith G.J. and Chen H., SARS coronavirus: An animal reservoir?, In: JSM Peiris, LJ Anderson,ADME Osterhaus, K Stohr, KY Yuen, Severe Acute Respiratory Syndrome. Blackwell Publishing, 2006, 79-83. |
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Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
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Li
O.T.W., |
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Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
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Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
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Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
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Smith G.J., Dhanasekaran V., Chen H. and Guan Y., Positive selection on the H5N1 Influenza virus genome, 25th Annual Meeting – American Society of Virology, University of Wisconsin. 2006. |
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Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
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Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
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Webster R.G., Hulse-Post D.J., Sturm-Ramirez K.M., Guan Y., Peiris J.S.M., Smith G.J. and Chen H., Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses, Avian Disease. 2007, 51: 269-272. |
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Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
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Zhang
J., Zhang Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian
Influenza Virus Receptors And H5n1 Virus Infection In Human Respiratory
Tract, The Options For The Control Of Influenza Vi June 17-23, Toronto,
Ontario, Canada. |
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Researcher
: Chen HKJ |
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List of Research Outputs |
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Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
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Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
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Lam H.Y., Chen H.K.J., Wong K.H., Chan K., Li P., Lee M.P., Tsang D.N., Yuen K.Y. and Yam W.C., Evaluation of NucliSens EasyQ™ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia , In: Elsevier, Journal of Clinical Virology. Elsevier, 2006, 38: 39-43. |
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Researcher
: Chen Y |
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List of Research Outputs |
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Zhou J., Lu L., Zhang B., Wong S., Chen Y., Poon K.M., Jiang S. and Zheng B., Genetic variations of type I interferon receptor 1 promoter and their association with chronic hepatitis B virus infection., Journal of Microbes and Infection. 2007, 2(1): 19-25. |
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Researcher
: Cheng VCC |
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List of Research Outputs |
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Che X.Y., Di B., Zhao G.P., Wang Y.D., Qiu L.W., Hao W., Wang M., Qin P.Z., Liu Y.F., Chan K.H., Cheng V.C.C. and Yuen K.Y., A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China. , Clinical infectious diseases. 2006, 43(1): e1-e5. |
|
Leung A.Y.H., Chow C.H., Kwok J.S.Y., Lui C.K., Cheng V.C.C., Yuen K.Y., Lie A.K.W. and Liang R.H.S., Safety of vacinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2007, 39(11): 661-5. |
|
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
|
Wong A.S.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Kwong Y.L. and Leung A.Y.H., Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation, Clinical Infectious Disease. 2007, 44(6): 830-837. |
|
Researcher
: Cheung CL |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Researcher
: Cheung CLN |
|
List of Research Outputs |
|
Ho P.L., Cheung C.L.N., Mak C.K., Tse C.W., Ng T.K., Cheung C.H.Y., Lam R., Lai R.W., Yung R.W. and Yuen K.Y., Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2007, 57(2): 145-151. |
|
Researcher
: Cheung CY |
|
Project Title: |
Determination of cellular receptors involved in differentially high pro-inflammatory induction by influenza A subtype H5N1 viruses in primary human monocyte-derived macrophages |
|
Investigator(s): |
Cheung CY |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
The pandemic threat posted by avian
influenza A H5N1 remains the major infectious disease threat currently
confronting humankind. This virus is entrenched in poultry across a wide
geographical distribution across |
|
List of Research Outputs |
|
Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
|
Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
|
Chan M.C.W., Chan W.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., The replication and pathogenicity of influenza A (H5N1) viruses infection in polarized human respiratory epithelium, The American Society For Virology, 25th Annual Meeting. 2006. |
|
Cheung
C.Y., Award for Outstanding Research
Postgraduate Student, The |
|
Cheung C.Y., Award to attend the Wellcome Trust Advanced Course in Functional Genomics and Systems Biology, Wellcome Trust Sanger Institute. 2007. |
|
Cheung C.Y., Host responses to avian influenza A (H5N1) infection, Frontiers in Biomedical Research. 2006. |
|
Cheung
C.Y., Li Ka Shing Prize, The |
|
Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
|
Kam Y.W., Kien F.S., Roberts A., Cheung C.Y., Lamirande E.W., Vogel L., Chu S.L., Tse K.S., Guarner J., Zaki S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Vaccine, Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro.. Epub, 2007, 25(4): 729-40. |
|
Mok K.P., Lee D.C.W., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Differential onset of apoptosis in influenza A virus H5N1 - and H1N1 - infected human blood macrophages, Journal of General Virology. 2007, 88(Pt 4): 1275-1280. |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
|
Zhou J., Law H.K.W., Tu W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Decreased T lymphocytes activation and Cytotoxic activity in avian influenza: an in vitro study, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 164. |
|
Zhou
J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of
chemokines and their receptors in adult and neonatal macrophages infected
with human or avian influenza viruses, Journal of Infectious Diseases.
Infectious Diseases Society of |
|
Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Interaction of mannose binding lectin with H1N1 and H5N1 influenza A viruses, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 110. |
|
ter Meulen J.A.N., van den Brink E.N., Poon L.L.M., Marissen W.E., Leung C.S.W., Cox F.R.E.E.K., Cheung C.Y., Bakker A.Q., Bogaards J.A., van Deventer E.L.S., Preiser W., Doerr H.W., Chow V.T., de Kruif J., Peiris J.S.M. and Goudsmit J., Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants, PLoS Medicine. 2006, 3 (7): 1071-1079. |
|
Researcher
: Cheung KW |
|
List of Research Outputs |
|
Cheung K.W. and Poon L.L.M., Biology of influenza a virus, ANNUALS of the New York Academy of Sciences. 2007, 1102: 1-25. |
|
Poon
L.L.M. and Cheung K.W.,
Biology of influenza A virus, Ann. N.Y. Acad. Sci. . |
|
Researcher
: Ching PTY |
|
List of Research Outputs |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Researcher
: Choi WYJ |
|
List of Research Outputs |
|
Chan C.P., Choi W.Y.J., Cao K., Wang M., Gao Y., Zhou D.H., Di B., Xu H.F., Leung M.F., Bergmann A., Lehmann M., Nie Y.M., Cautherley G.W., Fuchs D., Renneberg R. and Zheng B., Detection of serum neopterin for early assessment of dengue virus infection., Journal of Infection. 2006, 53(3): 152-158. |
|
Researcher
: Chong TK |
|
Project Title: |
Construction and characterization of delta AFMP1 delta AFMP2 deletion mutant of Aspergillus fumigatus |
|
Investigator(s): |
Chong TK, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
In this project, we propose to study the
essentiality and possible roles of AFMP1 and AFMP |
|
List of Research Outputs |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Researcher
: Chow KH |
|
List of Research Outputs |
|
Yang Z., Ho P.L., Liang G., Chow K.H., Wang Q., |
|
List of Research Outputs |
|
Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
|
Researcher
: Curreem SOT |
|
List of Research Outputs |
|
Woo P.C.Y., Lau S.K.P., Lin A.W.C., Curreem S.O.T., Fung A.M.Y. and Yuen K.Y., Surgical site abscess caused by Lactobacillus fermentum identified by 16S ribosomal RNA gene sequencing , Diagnostic Microbiology and Infectious Disease. 2007, 58: 251-254. |
|
Researcher
: Dhanasekaran V |
|
List of Research Outputs |
|
Bahl
J., Dhanasekaran V., Smith G.J., Webster R.G. and Guan Y., Evolutionary dynamics of avian
influenza A virus in the natural reservoir, Options for the control of
influenza VI, |
|
Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
|
Dhanasekaran V., Jeewon R. and Hyde K.D., Molecular taxonomy, origins and ecology of freshwater ascomycetes, Fungal Diversity. 2006, 23: 367-406. |
|
Kodsueb R., Dhanasekaran V., Aptroot A., Lumyong S., Mckenzie E.H.C., Hyde K.D. and Jeewon R., The family Pleosporaceae: intergeneric relationships and phylogenetic perspectives based on sequence analyses of partial 28S rDNA, Mycologia. 2006, 98: 571-583. |
|
|
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Smith G.J., Dhanasekaran V., Chen H. and Guan Y., Positive selection on the H5N1 Influenza virus genome, 25th Annual Meeting – American Society of Virology, University of Wisconsin. 2006. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
|
Researcher
: Du L |
|
List of Research Outputs |
|
Du L.,
Zhou Y., He Y., Ma S., Yuen K.Y., Jiang S. and Zheng B., Intranasal vaccination with
adeno-associated virus encoding the receptor-binding domain of severe acute
respiratory syndrome coronavirus S protein induces strong and prolonged
systemic and local antibodies with neutralizing activity., The American
Society for Virology 25th Annual Meeting (25th ASV).. |
|
Du L., Zhao G., He Y., Guo Y., Zheng B., Jiang S. and Zhou Y., Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model., Vaccine. 2007, 25(15): 2832-2838. |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Lu W., Zheng
B., Xu K., Schwarz W., Du L.,
Wong K.H., Chen J., Duan S., Deubel
V. and Sun B., Severe acute respiratory syndrome-associated coronavirus |
|
Researcher
: Duan L |
|
List of Research Outputs |
|
Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
|
Researcher
: Fan X |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Researcher
: Fan YY |
|
List of Research Outputs |
|
Lau S.K.P., Woo P.C.Y., Fan Y.Y., Ma S.S.L., Hui W.T., Au S.Y., Chan L.L., Chan J.Y.F., Lau A.T.K., Leung K.Y., Pun T.C.T., She H.H.L., Wong C.Y., Wong L.L.L. and Yuen K.Y., Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong , Journal of Applied Microbiology. 2007, 103: 507-515. |
|
Lau
S.K.P., Woo P.C.Y., Fan Y.Y., Lee R.C.M., Teng L.L. and Yuen K.Y., Seasonal and tissue
distribution of Laribacter hongkongensis, a novel bacterium associated with
gastroenteritis, in retail freshwater fish in |
|
Researcher
: Gao Y |
|
List of Research Outputs |
|
Ng S.M., Gao Y., Chau D.H.W., Li H.Y., Lai L., Huang P.T., Huang C., Huang J.J., Chen Y., Kung H.F. and Lin M.C., A Novel Glioblastoma Cancer Gene Therapy Using AAV-mediated Long-term Expression of Human TERT C-terminal Polypeptide via Multiple Mechanisms, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
|
Ng S.M., Gao Y., Chau D.H.W., Li H.Y., Lai L.H., Huang P.T., Huang C.F., Huang J.J., Chen Y.C., Kung H.F. and Lin M.C., A Novel Glioblastoma Cancer Gene Therapy Using AAV-mediated Long-term Expression of Human TERT C-terminal Polypeptide, Cancer Gene Therapy. 2007, 14(6): 561-72. |
|
Shen Z., Yang Z., Gao Y., Poon R.T.P., Fan S.T., He M.L., Li T.P., Gan R.B., Kung H.F. and Lin M.C., Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits the Growth and Metastasis of Hepatocellular Carcinoma in Rats, 10th Annual Meeting of the American Society of Gene Therapy, May 30-June 3, 2007, at the Washington State Convention and Trade Center in Seattle, WA.. 2007. |
|
Shen Z., Yang Z., Gao Y., Liu C.C., Ng S.M., Fan S.T., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., Sustained Expression of Kringle 1 Domain of HGF (HGFK1) Effectively Inhibits Hepatocellular Carcinoma Tumor Growth and Metastasis by a Novel Mechanism, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
|
Researcher
: Gao Y |
|
List of Research Outputs |
|
Ng S.M., Gao Y., Chau D.H.W., Li H.Y., Lai L., Huang P.T., Huang C., Huang J.J., Chen Y., Kung H.F. and Lin M.C., A Novel Glioblastoma Cancer Gene Therapy Using AAV-mediated Long-term Expression of Human TERT C-terminal Polypeptide via Multiple Mechanisms, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
|
Ng S.M., Gao Y., Chau D.H.W., Li H.Y., Lai L.H., Huang P.T., Huang C.F., Huang J.J., Chen Y.C., Kung H.F. and Lin M.C., A Novel Glioblastoma Cancer Gene Therapy Using AAV-mediated Long-term Expression of Human TERT C-terminal Polypeptide, Cancer Gene Therapy. 2007, 14(6): 561-72. |
|
Shen Z., Yang Z., Gao Y., Poon R.T.P., Fan S.T., He M.L., Li T.P., Gan R.B., Kung H.F. and Lin M.C., Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits the Growth and Metastasis of Hepatocellular Carcinoma in Rats, 10th Annual Meeting of the American Society of Gene Therapy, May 30-June 3, 2007, at the Washington State Convention and Trade Center in Seattle, WA.. 2007. |
|
Shen Z., Yang Z., Gao Y., Liu C.C., Ng S.M., Fan S.T., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., Sustained Expression of Kringle 1 Domain of HGF (HGFK1) Effectively Inhibits Hepatocellular Carcinoma Tumor Growth and Metastasis by a Novel Mechanism, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
|
Researcher
: Guan Y |
|
Project Title: |
Vaccines for the control of H5N1 and other avian influenza viruses |
|
Investigator(s): |
Guan Y |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
The |
|
Start Date: |
04/2002 |
|
Abstract: |
|
To study vaccines for the control of H5N1 and other avian influenza viruses. |
|
Project Title: |
Genetic determinants of influenza virus for inter-species transmission: studies using a reverse genetic approach |
|
Investigator(s): |
Guan Y, Peiris JSM, Poon LLM, Shortridge KF |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
08/2002 |
|
Abstract: |
|
Avian influenza viruses can directly impact on human and animal health and thus cause economic loss. The study aims to establishing a reverse genetic system and to determine the biological significance of the deletion of NA stalk and the NS genes, particularly in relation to the host-restriction and pathogenesis. Results can enhance understanding of the machanism of inter-species transmission of influenza virus. |
|
Project Title: |
Searching for the precursor of SARS-Cov in Southern China |
|
Investigator(s): |
Guan Y |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To find source of SARS-Cov, and how this virus emerged in humans. |
|
Project Title: |
Genomic characterization, population ecology and genetics of H9N2 influenza viruses in southern China |
|
Investigator(s): |
Guan Y, Smith GJ |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
10/2006 |
|
Abstract: |
|
To characterise the number of novel reassortnat H9N2 influenza virus genotypes circulating a poultry in southern China; to understand the ecology of H9N2 viruses in southern China and how this contributes to the generation of those novel genotypes; to determine the inter-relations of h5N1 and H9 N2 viruses that are co-circulating in poultry in southern China. |
|
Project Title: |
The role of migratory birds in the transmission of H5N1 Influenza virus in eastern Asia |
|
Investigator(s): |
Guan Y, Chen H, Smith GJ |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To observe the epidemiology of influenza viruses of migratory birds in Southern China; to determine whether influenza viral gene pool in migratory birds contribute to generate novel reassortant H5N1 influenza viruses with pandemic potential; to investigate whether H5N1 influenza virus will become established in migratory bird fowls and result in further expansion of geographic distribution in Eurasian continent. |
|
List of Research Outputs |
|
Bahl
J., Dhanasekaran V., Smith G.J., Webster R.G. and Guan Y., Evolutionary dynamics of
avian influenza A virus in the natural reservoir, Options for the control
of influenza VI, |
|
Bermejo-Martin J.F., Kelvin D.J., Guan Y., Chen H., Perez-Breña P., |
|
Boltz D.A., Douangngeun D., Sinthasak S., Phommachanh P., Rolston S., Chen H., Guan Y., Peiris J.S.M., Smith G.J. and Webster R.G., H5N1 influenza viruses in Lao People’s Democratic Republic, Emerging Infectious Diseases. 2006, 12: 1593-1595. |
|
Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
|
Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
|
Chua T.H., Ellis T.M., Wong C.W., Guan Y., Ge S.X., Peng G., Lamichhane C., Maliadis C., Tan S.W., Selleck P. and Parkinson J., Performance evaluation of five detection tests for avian influenza antigen with various avian samples., Avian diseases. 2007, 51(1): 96-105. |
|
Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
|
Guan
Y., Zhong N.S., Chen H., Smith G.J. and Zheng B., An averted SARS outbreak, In:
JCK Chan, VCW Taam Wong, Challenges of Severe Acute Respiratory Syndrome.
|
|
Guan
Y., Chairperson for session: Molecular
epidemiology and clinical microbiology, 1st Meeting of The Pasteur Asia
Network on Emerging Respiratory Diseases: From Surveillance to Diagnostic in |
|
Guan Y., Characterization of low pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses , 2007 International Symposium & Annual Meeting: Challenging to Emerging Infectious Diseases in Seoul from 28 - 29 June, 2007, organised by The Korean Society for Microbiology and Biotechnology. 2007. |
|
Guan
Y., Characterization of low pathogenic H5
subtype influenza viruses from Eurasia: Implications for the origin of highly
pathogenic H5N1 viruses, 15th International Environmental Bioindicators
Conference, 7 - 8 Jun, 2007 at |
|
Guan Y., Characterization of low pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses, Hong Kong - British Columbia, Workshop On Emerging Infectious Diseases at University of British Columbia in Vancouver from 15 - 16 June, 2007 (Session of Epidemiology & Surveillance). 2007. |
|
Guan Y., Smith G.J., Peiris J.S.M. and Webster R.G., Comments on the Fujian-like strain of avian influenza H5N1., Poult Sci. 2007, 86(3): 435-436. |
|
Guan
Y., Evolution and Prevalence of Avian Influenza
Viruses in Southern China, IX International Symposium on Respiratory Viral
Infections in |
|
Guan Y., Human Avian Flu: etiology and transmission, Guangzhou-Edinburgh Workshop on Zoonotic and Emerging Diseases in Guanzhou, 22nd March 2007. 2007. |
|
Guan
Y., Recent Development of H5N1 Influenza
Virus in |
|
Guan
Y., Recent Development of H5N1 Influenza
virus in |
|
Guan Y., Field H., Smith G.J. and Chen H., SARS coronavirus: An animal reservoir?, In: JSM Peiris, LJ Anderson,ADME Osterhaus, K Stohr, KY Yuen, Severe Acute Respiratory Syndrome. Blackwell Publishing, 2006, 79-83. |
|
Guan
Y., The recent development of H5N1 influenza
virus in poultry in |
|
Guan
Y., US-Asia Health Journalism Fellowship
2006, Emerging & Re-emerging Infectious Diseases, Sep3-6, 2006, The |
|
Horimoto T., Takada A., Fujii K., Goto H., Hatta M., Watanabe S., Iwatsuki-Horimoto K., Ito M., Tagawa-Sakai Y., Yamada S., Ito T., Imai M., Itamura S., Odagiri T., Tashiro M., Lim W.W.L., Guan Y., Peiris J.S.M. and Kawaoka Y., The development and characterization of H5 influenza virus vaccines derived from 1 2003 human isolate, Vaccine. 2006, 24: 3669-3676. |
|
Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
|
Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen D.P.H., Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L.M., Lim W.W.L., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris J.S.M. and Uyeki T.M., New England Medical Journal, Three Indonesian clusters of h5N1 virus infection in 2005. 2007, 356(13): 1375. |
|
Kung N.Y., Morris R.S., Perkins N.R., Sims L.D., Ellis T.M., Bissett L., Chow M., Shortridge K.F., Guan Y. and Peiris J.S.M., Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002., Emerging Infectious Diseases. 2007, 13(3): 412-8. |
|
Lau
E.H.Y., Leung C.Y.H., Zheng L.J.,
Mak S.P., Guan Y., Leung G.M. and Peiris J.S.M., The effect of
interventions on influenza A (H9N2) isolation in Hong Kong's live poultry
markets, 1999-2005 (abstract), IX International Symposium on Respiratory
Viral Infections, 3-6 March 2007, Hong Kong. Hong Kong, |
|
Li
O.T.W., |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
|
Peiris J.S.M., de Jong M.D. and Guan Y., Avian Influenza Virus (H5N1): a Threat to Human Health, Clinical Microbiology Reviews. American Society for Microbiology, 2007, April 2007: 243-267. |
|
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
|
Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Smith G.J., Dhanasekaran V., Chen H. and Guan Y., Positive selection on the H5N1 Influenza virus genome, 25th Annual Meeting – American Society of Virology, University of Wisconsin. 2006. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
|
Webster R.G., Hulse-Post D.J., Sturm-Ramirez K.M., Guan Y., Peiris J.S.M., Smith G.J. and Chen H., Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses, Avian Disease. 2007, 51: 269-272. |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Zhang
J., Zhang Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian Influenza
Virus Receptors And H5n1 Virus Infection In Human Respiratory Tract, The
Options For The Control Of Influenza Vi June 17-23, Toronto, Ontario, Canada.
|
|
de jong M.D., Simmons C.P., Thanh T.T., Hien V.M., Smith G.J., Chau T.N., Hoang D.M., Van Vinh Chau N., Khanh T.H., Dong V.C., Qui P.T., Van Cam B., Ha D.Q., Guan Y., Peiris J.S.M., Chinh N.T., Hien T.T. and Farrar J., Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia., Nature medicine. 2006. |
|
Researcher
: Ho CC |
|
List of Research Outputs |
|
Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
|
Project Title: |
A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2000 |
|
Abstract: |
|
To identify the frequency of occurrence of vancomycin tolerance in Streptococcus pneumoniae; to identify novel mutations in the histdine kinase (vncS) of tolerant pneumococci. |
|
Project Title: |
Molecular
epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong
kong and |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To define the molecular epidemiology of
fluoroquinolone-resistant strains of S. pneumoniae isolated in Hong Kong and |
|
Project Title: |
Clinical outcome and impact on health care utilization of invasive pneumococcal disease in the era of antimicrobial resistance |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Health Care and Promotion Fund - Research Grant Projects |
|
Start Date: |
08/2002 |
|
Abstract: |
|
To determine the impact of antibiotic resistance on patient outcome in invasive pneumococcal disease and to what extent additional health care resources are utilized as a result of the antibiotic resistance in a cohort of patients between 1997 to 2000; to document the serotypes of S. pneumoniae that casue invasive infection in the same cohort of patients. |
|
Project Title: |
Risk factors for SARS in health care workers following incubation of SARS patients |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To identify factors associated with SARS transmission in HCW who participated in intubation of SARS patients; to define the transmission probability of an intubation procedure of SARS patient and to describe the intubation procedural practice of clinicians in the first two months of the outbreak. |
|
Project Title: |
Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To determine the frequency of occurrence of first step fluoroquinolone-resistant determining mutations among isolates categorized as susceptible by the currently accepted clinical breakpoints. |
|
Project Title: |
Antimicrobial resistance among uropathogens causing well-defined episodes of uncomplicated cystitis among adult women in primary care settings |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2006 |
|
Abstract: |
|
(1) to assess prevalence of antimicrobial resistnace among uropathogens causing well-defined episodes of acute uncomplicated cystitis in adult women; (2) to assess the clonality, resistant determinants and virulence factor profiles of antibiotic-resistant strains of uropathogenic E. coli. |
|
Project Title: |
Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management |
|
Investigator(s): |
Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
04/2006 |
|
Abstract: |
|
(1) to evaluate rapid tests for genotypic detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis in respiratory specimens and culture isolates; (2) to assess the effects of a model for targeted testing of patients with risks for multidrug-resistant tuberculosis on patient management |
|
Project Title: |
The epidemiological relationships between CTX-M producing Escherichia coli from animal and human sources |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
The aim of this study is to test the hypothesis that (1) there are epidemiological links between antibiotic-resistant E. coli in the three ecological compartments represented by food animals, community and hospital; (2) expansion of limited clones contribute to the observed CTX-M frequencies and that the resistant clones were derived from antibiotic-susceptible strains acquiring resistance determinants; (3) there are multiple genetic background among the gene capture units carrying the CTX-M genes and the same profile of genetic background are present among strains from animal and human. |
|
List of Research Outputs |
|
Ho P.L., Antimicrobial resistance in Haemophilus species, M.Phil thesis submitted by Mr. Mak Chun Kit Gannon. 2006. |
|
Ho
P.L., Emergence of CTX-M extended-spectrum
beta-lactamases-producing urinary Escherichia coli isolates in |
|
Ho P.L., Becker M. and Chan M.M.W., Emerging occupational lung infections., International Journal of Tuberculosis and Lung Disease. 2007, 11(7): 710-21. |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Ho P.L., Cheung C.L.N., Mak C.K., Tse C.W., Ng T.K., Cheung C.H.Y., Lam R., Lai R.W., Yung R.W. and Yuen K.Y., Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2007, 57(2): 145-151. |
|
Ho P.L., Molecular epidemiology and isoniazid mechanism in Mycobacterium tuberculosis, Ph.D. thesis (Co-supervisor) submitted by Mr. Eric Tung Yiu Leung. 2006. |
|
Ho P.L. and Wong S.S.Y., Reducing bacterial resistance with IMPACT-Interhospital Multi-disciplinary Program on Antimicrobial Chemotherapy., In: Ho PL, Wong SSY (ed.), 2006, 3: 1-124. |
|
Leung W.S., |
|
Wong S.S.Y., Ho P.L. and Yuen K.Y., Evolution of antibiotic resistance mechanism and its relevance to dialysis-related infection, Peritoneal Dialysis International. Multimed Inc., 2007, 27 (Supplement 2): S272-S285. |
|
Xie X., Li Y., Chwang A.T.Y., Ho P.L. and Seto W.H., How far droplets can move in indoor environments – Revisiting Wells evaporation-falling curve of droplets., Indoor Air. 2007, 17 (3): 211-225. |
|
Yam W.C., Lam T.H., Wong K.C., Yuen K.Y. and Ho P.L., Differential gene expression associated with phenotypic virulence of Mycobacterium tuberculosis, In: Keystone Symposia, Keystone Symposia - Tuberculosis : From Lab Research to Field Trials. 2007. |
|
Yang Z., Ho P.L., Liang G., Chow K.H., Wang Q., |
|
Researcher
: Huang K |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Zhang
J., Zhang Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian Influenza
Virus Receptors And H5n1 Virus Infection In Human Respiratory Tract, The
Options For The Control Of Influenza Vi June 17-23, Toronto, Ontario, Canada.
|
|
Researcher
: Huang Y |
|
List of Research Outputs |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Hui CK |
|
Project Title: |
Significance of occult hepatitis B infection in patients undergoing autologous HSCT |
|
Investigator(s): |
Hui CK, Liang RHS, Lau G, Lie AKW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
10/2006 |
|
Abstract: |
|
(1) The occurrence of de novo HBV or occult HBV infection with or without clinical hepatitis after HSCT in HBsAg negative patients pre-HSCT; (2) the risk of transmitting de novo or occult HBV from occult HBV infected blood products to HBsAg negative immunocompromised patients. |
|
List of Research Outputs |
|
Researcher
: Im SWK |
|
Project Title: |
Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors |
|
Investigator(s): |
Im SWK, Yam WC |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To determine the exposure of the |
|
Researcher
: Jayawardena S |
|
List of Research Outputs |
|
Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
|
Researcher
: Kao RYT |
|
Project Title: |
Application of chemical genetic approaches to dissect the molecular basis of virulence and dimorphism in Penicillium marneffei |
|
Investigator(s): |
Kao RYT, Yuen KY, Sun H |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
In conjunction with conventional genetic approaches (such as gene cloning and gene inactivation, etc.), we set out to employ chemical genetic approach - the use of high-throughput screening (HTS) technologies to identify biologically active small molecules that will interfere with particular cellular processes/biological pathways/gene products - to dissect the molecular basis of virulence and dimorphism in Penicillium marneffei. Forward chemical genetics will be used to identify small molecule compounds that will interfere with host-pathogen interactions and dimorphism in P. marneffei. Reverse chemical genetics will be used to identify small molecules that will have specific inhibitory effects on MetAP1 or MetAP2 (essential enzymes involved in removal of N-terminal methionine) of P. marneffei. Resulting specific inhibitors of MetAPs will be tested in in vitro intracellular survival and in vivo animal infection models. |
|
Project Title: |
Identification of small molecule inhibitors of Staphylococcus aureus methionine aminopeptidase by reverse chemical genetics |
|
Investigator(s): |
Kao RYT |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
Staphylococcus aureus forms part of the normal flora of human hosts as a common inhabitant of the nasal tract and the skin of humans and animals (Peacock et al., 2001). S. aureus causes a variety of infections in humans and animals. Infections are initiated when a breach of the skin or mucosal barrier allows S. aureus access to adjoining tissues or the bloodstream. During the pre-antibiotic era, many staphylococcal invasive infections led to the death of the patient. This effect was relieved by the discovery of penicillin in the 1940s. However, by the end of 1950s, approximately 50% of hospital isolates of this bacterium were penicillin resistant. Methicillin and other semi-synthetic derivative of penicillin were then used to treat S. aureus infections. In another few years, methicillin-resistant S. aureus (MRSA) were found in hospitals, leaving vancomycin as the last line of defence against staphylococcal infections (Mann, J. and Crabbe, M.J.C., 1996). However, strains of S. aureus with intermediate resistance to vancomycin are increasingly being found (Projan, S.J., 2000). Clearly, research in the pathogenesis of S. aureus and identification of novel targets for antibacterial therapy against this pathogen is imminent. Co- and post-translational modifications have long been recognized as essential steps for the maturation of proteins for proper folding, regulation, function, targeting and eventually degradation (Bradshaw, 1989; Meinnel, Mechulam, and Blanquet, 1993; Bradshaw, Brickley, and Walker, 1998; Arfin and Bradshaw, 1988). Since protein synthesis begins at the amino-terminus, modification at this site is one of the earliest steps and most common events in protein processing (Lowther and Matthews, 2002). Translation of proteins is initiated with methionine in eukaryotes and N-formyl methionine in prokaryotes, mitochondria, and chloroplasts. The N-formyl group is removed from proteins in prokaryotes and eukaryotic organelles by a deformylase, leaving a methionine residue at the amino terminus (Meinnel, Mechulam, and Blanquet, 1993). However, the majority of mature proteins do not retain the initiator residue. In the cytosolic extract of Escherichia coli only 40% of the polypeptide chains retain the N-terminal methionine, whereas about 50% display alanine, serine, or threonine at their N-termini (Waller, 1963). Methionine aminopeptidase (MetAP) is the enzyme responsible for the catalytic cleavage of the N-terminal methionine from proteins, when the penultimate residue has a small and uncharged side-chain (Tsunasawa, Stewart, and Sherman, 1985; Huang et al., 1987; Hirel et al., 1989). MetAPs have been proven essential in Gram negative bacteria, such as E. coli and Salmonella typhimurium (Chang, McGary, and Chang, 1989; Miller et al., 1989), and in Saccharomyces cerevisiae (Li and Chang, 1995). Its physiological importance has given rise to considerable interest among researchers to design antimicrobial inhibitors that specifically target this enzyme. The vitality of this gene in Gram positive bacteria has just been experimentally illustrated by our group recently (Wong et. al. Manuscript in preparation). The demonstration of map as an essential gene in Staphylococcus aureus has validated map as an attractive drug target for antibacterial and antifungal drug development. Recent advancements in synthetic organic chemistry, molecular biology, and informatics have made possible the use of large collections of small molecules (chemical libraries) to investigate protein/chemical interactions in vitro and in vivo (Kao et al. 2002, 2004; Degterev et al., 2001; Peterson et al., 2000; Mayer et al., 1999). The term "chemical genetics” has been coined to signify the use of chemicals to systematically perturb, and thus determine, the function of proteins in the same way that mutations are used in classical genetics. In forward chemical genetics, small molecules that induce altered phenotypes in cells or organisms are identified and their cellular targets will then be determined subsequently. In reverse chemical genetics, small molecules that interact with a known, purified protein are identified in vitro and their effects on cells or organisms will then be examined. We intend to employ high-throughput screened (HTS) based reverse chemical genetics to identify small molecules that will have specific inhibitory effects on the S. aureus MetAP-I (SaMetAP-I). Resulting specific inhibitors of SaMetAP-I will be tested in cell-based assays (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and E. coli) to determine their in vivo antimicrobial effects. |
|
Project Title: |
Mode of action of a lead anti-influenza compound identified by chemical genetics |
|
Investigator(s): |
Kao RYT |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Based on the concept of chemical genetics
and in conjunction with the high-throughput screening (HTS) technologies we
have developed, we set out to establish a HTS-based chemical genetic platform
for the identification of biologically active small molecule compounds that
will perturb most, if not all, biological pathways involved in the
pathogenesis of influenza A viruses in cellular models. Forward chemical
genetics has been employed to identify small molecule compounds that will
interfere with infectivity of human influenza A/WSN/33 (H1N1) in Madin-Darby
canine kidney (MDCK) cells. Primary screening of the library has identified
more than 1,000 compounds that can perturb the infectivity of H1N1 virus in
cell-based assays. A sampling survey of 70 primary hits indicates that ~10%
of the hits have EC50 (median effective concentration) at or below 10 microM
[determined by MTT (3-[4,5-dimethylth-iazol-2-yl]-2,5-diphenyltetrazolium
bromide) assay and PRA (plaque reduction assay)]. The result is in good
agreement with the ones we obtained from our previously published SARS-CoV
study. One particular lead compound FA5123
{[4-(2-Chloro-4-nitro-phenyl)-2-methyl-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methyl-isoxazol-4-yl]-methanone}
has been identified (figure 1). FA5123 inhibits influenza A/WSN/33 (H1N1) in
MDCK cells with an EC50 of 5 microM and TC50 (median toxicity concentration)
> |
|
Project Title: |
Methionine aminopeptidase (MetAP) as a novel target for development of antibiotic therapeutics against Staphylococcus aureus (S. aureus) - a proteomic approach |
|
Investigator(s): |
Kao RYT, Yuen KY, Che CM, Siu AFM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
02/2006 |
|
Abstract: |
|
Using proteomic approach in conjunction with conventional genetic manipulations of S. aureus wild-type strain and its newly constructed MetAP knockout strain, we intend to gain insight into the physiological roles of MetAP. The biomarkers of MetAP deficient state in S. aureus will be studied and be used as future platform for development and validation of MetAP specific antibiotics. |
|
Project Title: |
Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies |
|
Investigator(s): |
Kao RYT |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Objectives of the proposed project: Co-
and post-translational modifications have long been recognized as essential steps
for the maturation, regulation, and eventually degradation of proteins. Since
protein synthesis begins at N-terminus with methionine or N-formyl methionine
(initiator methionine), modification at this site becomes one of the earliest
and most important steps determining the fate of the translating peptide.
Methionine aminopeptidases (MetAPs), the enzymes responsible for the
catalytic removal of the N-terminal methionine, are defined by their highly
conserved substrate specificity dictated by the residue adjacent to the
initiator methionine residue. Extensive biochemical and mutational studies
have confirmed that if the second residue in the primary sequence is small
and uncharged (e.g. |
|
List of Research Outputs |
|
Kung N.Y., Morris R.S., Perkins N.R., Sims L.D., Ellis T.M., Bissett L., Chow M., Shortridge K.F., Guan Y. and Peiris J.S.M., Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002., Emerging Infectious Diseases. 2007, 13(3): 412-8. |
|
Researcher
: Lai ELY |
|
List of Research Outputs |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Researcher
: Lam HY |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Lam H.Y., Chen H.K.J., Wong K.H., Chan K., Li P., Lee M.P., Tsang D.N., Yuen K.Y. and Yam W.C., Evaluation of NucliSens EasyQ™ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia , In: Elsevier, Journal of Clinical Virology. Elsevier, 2006, 38: 39-43. |
|
Researcher
: Lam HY |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Lam H.Y., Chen H.K.J., Wong K.H., Chan K., Li P., Lee M.P., Tsang D.N., Yuen K.Y. and Yam W.C., Evaluation of NucliSens EasyQ™ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia , In: Elsevier, Journal of Clinical Virology. Elsevier, 2006, 38: 39-43. |
|
Researcher
: Lam SF |
|
List of Research Outputs |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Lam SY |
|
List of Research Outputs |
|
Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
|
Researcher
: Lam TH |
|
List of Research Outputs |
|
Yam W.C., Lam T.H., Wong K.C., Yuen K.Y. and Ho P.L., Differential gene expression associated with phenotypic virulence of Mycobacterium tuberculosis, In: Keystone Symposia, Keystone Symposia - Tuberculosis : From Lab Research to Field Trials. 2007. |
|
Researcher
: Lau CY |
|
List of Research Outputs |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Researcher
: Lau SKP |
|
Project Title: |
Usefulness of microseq 500 16S rDNA identification system for identification of anaerobic gram-positive bacilli isolated from blood cultures |
|
Investigator(s): |
Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Completion Date: |
10/2006 |
|
Abstract: |
|
To evaluate the usefulness of the MicroSeq 500 16S rDNA bacterial identification system in the identification of anaerobic gram-positive bacilli isolated from blood cultures; to compare the results from the MicroSeq system with those from commercial biochemical identification kit. |
|
Project Title: |
Environmental surveillance of Laribacter hongkongensis, a diarrheal pathogen discovered in Hong Kong |
|
Investigator(s): |
Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
12/2004 |
|
Abstract: |
|
To conduct a territory-wide,
environmental surveillance in |
|
Project Title: |
Antibiotic susceptibility profiles and cloning and characterization of antibiotic resistance genes of Laribacter hongkongensis |
|
Investigator(s): |
Lau SKP, Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
07/2005 |
|
Abstract: |
|
To elucidate the antibiotic susceptibility profile of human and animal strains of L. hongkongensis>; to compare macrobroth dilution method, E-test and disk diffusion test for antibiotic susceptibility testing in L. hongkongensis; to clone and characterize the beta-lactamase and tetracycline resistance genes of L. hongkongensis. |
|
Project Title: |
Characterization of two novel anaerobic, gram-positive bacilli recovered from blood cultures of patients |
|
Investigator(s): |
Lau SKP, Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
The objectives of this study are to
characterize two novel anaerobic, gram-positive bacilli recovered from blood
cultures of patients in |
|
Project Title: |
Development of a multilocus sequence typing system for Laribacter hongkongensis |
|
Investigator(s): |
Lau SKP, Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Understanding the epidemiology of infectious disease pathogens is the first step in combating infectious diseases. This study will help facilitate the comparison of different strains of L. hongkongensis isolated form different hosts or the environment; and in turn, the sources of human infections and possible control measures. |
|
Project Title: |
Characterization of an unidentified anaerobic, gram-positive bacillus recovered from blood culture of a patient with acute proctitis |
|
Investigator(s): |
Lau SKP, Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
The objective of this study is to characterize an unidentified anaerobic, gram-positive bacillus recovered from blood culture of a patient. |
|
List of Research Outputs |
|
Cai J., Woo P.C.Y., Lau S.K.P., Smith D.K. and Yuen K.Y., Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota., Journal of molecular evolution. 2006, 63(1): 1-11. |
|
Lau S.K.P., Woo P.C.Y., Woo G.K.S., Fung A.M.Y., Ngan A.H.Y., Song Y., Liu C., Summanen P., Finegold S.M. and Yuen K.Y., Bacteraemia caused by Anaerotruncus colihominis and emended description of the species, Journal of Clinical Pathology. 2006, 59: 748-752. |
|
Lau S.K.P., Teng L.L., Leung K.W., Li N.K., Ng K.H., Chau K.Y., Que T.L., Woo P.C.Y. and Yuen K.Y., Bacteremia caused by Solobacterium moorei in a patient with acute proctitis and carcinoma of the cervix , Journal of clinical microbiology. 2006, 44(8): 3031-3034. |
|
Lau S.K.P., McNabb A., Woo G.K.S., Hoang L., Fung A.M.Y., Chung L.M.W., Woo P.C.Y. and Yuen K.Y., Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada, Journal of Clinical Microbiology. 2007, 45: 395-401. |
|
Lau S.K.P., Human bocavirus infections in children in Hong Kong, 17th European Congress of Clinical Microbiology and Infectious Diseases 2007, Munich, Germany. 2007. |
|
Lau S.K.P., Woo P.C.Y., Fan Y.Y., Ma S.S.L., Hui W.T., Au S.Y., Chan L.L., Chan J.Y.F., Lau A.T.K., Leung K.Y., Pun T.C.T., She H.H.L., Wong C.Y., Wong L.L.L. and Yuen K.Y., Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong , Journal of Applied Microbiology. 2007, 103: 507-515. |
|
Lau S.K.P., Laribacter hongkongensis and Penicillium marneffei genome projects, HKU-UBC Emerging Infectious Diseases Workshop (HK). 2006. |
|
Lau
S.K.P., SARS coronavirus: from human to civet
and bat., Emerging Infectious Disease symposium ( |
|
Lau
S.K.P., Woo
P.C.Y., Fan Y.Y., Lee R.C.M., Teng L.L. and Yuen K.Y., Seasonal and tissue
distribution of Laribacter hongkongensis, a novel bacterium associated with
gastroenteritis, in retail freshwater fish in |
|
Wong S.S.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Bats as a continuing source of emerging infections in humans., Reviews in Medical Virology. 2007, 17: 67-91. |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Woo P.C.Y., Teng L.L., Ma S.S.L., Lau S.K.P. and Yuen K.Y., Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis, New Microbiologica. 2007, 30: 139-146. |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Woo
P.C.Y., Wang M., Lau S.K.P.,
Xu H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Woo P.C.Y., Chung M.W.C., Teng L.L., Tse H., Pang S.S.Y., Lau V.Y.T., Wong V.W.K., Kam K., Lau S.K.P. and Yuen K.Y., In silico analysis of 16S ribosomal RNA gene sequencing-based methods for identification of medically important anaerobic bacteria, Journal of Clinical Pathology. 2006, 60: 576-579. |
|
Woo P.C.Y., Lau S.K.P., Lin A.W.C., Curreem S.O.T., Fung A.M.Y. and Yuen K.Y., Surgical site abscess caused by Lactobacillus fermentum identified by 16S ribosomal RNA gene sequencing , Diagnostic Microbiology and Infectious Disease. 2007, 58: 251-254. |
|
Researcher
: Lee MY |
|
Project Title: |
Role of Cyclooxygenase-2 (COX-2) in Pro-inflammatory Response of Severe Acute Respiratory Syndrome (SARS) Coronavirus-Infected Human Primary Monocyte-derived Macrophages and the Potential Use of its Inhibitors for the Therapy of SARS |
|
Investigator(s): |
Lee MY, Peiris JSM, Cheung CY, Nicholls JM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Severe acute respiratory syndrome (SARS)
emerged firstly in |
|
Project Title: |
Role of cyclooxygenase-2 (COX-2) influenza A (subtype H5N1) viral pathogenesis and the potential use of its inhibitors for the therapy of H5N1 disease |
|
Investigator(s): |
Lee MY, Peiris JSM, Cheung CY |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To investigate the role of COX |
|
Researcher
: Lee SS |
|
List of Research Outputs |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Researcher
: Leung CSW |
|
List of Research Outputs |
|
ter Meulen J.A.N., van den Brink E.N., Poon L.L.M., Marissen W.E., Leung C.S.W., Cox F.R.E.E.K., Cheung C.Y., Bakker A.Q., Bogaards J.A., van Deventer E.L.S., Preiser W., Doerr H.W., Chow V.T., de Kruif J., Peiris J.S.M. and Goudsmit J., Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants, PLoS Medicine. 2006, 3 (7): 1071-1079. |
|
Researcher
: Leung CYH |
|
List of Research Outputs |
|
Lau
E.H.Y., Leung C.Y.H.,
Zheng L.J., Mak S.P., Guan Y., Leung G.M. and Peiris J.S.M., The effect of
interventions on influenza A (H9N2) isolation in Hong Kong's live poultry
markets, 1999-2005 (abstract), IX International Symposium on Respiratory
Viral Infections, 3-6 March 2007, Hong Kong. Hong Kong, |
|
Li
O.T.W., |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Researcher
: Li K |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Researcher
: Li KSM |
|
List of Research Outputs |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Li L |
|
List of Research Outputs |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Researcher
: Li OTW |
|
List of Research Outputs |
|
Li
O.T.W., |
|
Researcher
: Li PCK |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Researcher
: Lim WWL |
|
List of Research Outputs |
|
Buchy P., Mardy S., Vong S., Toyoda T., Aubin J.T., Miller M., Touch S., Sovann L., Dufourcq J.B., Richner B., Tu P.V., Tien N.T., Lim W.W.L., Peiris J.S.M. and Van der Werf S., Influenza A/H5N1 virus infection in humans in Cambodia., Journal of Clinical Virology. Epub, 2007, 39(3): 164-8. |
|
Horimoto T., Takada A., Fujii K., Goto H., Hatta M., Watanabe S., Iwatsuki-Horimoto K., Ito M., Tagawa-Sakai Y., Yamada S., Ito T., Imai M., Itamura S., Odagiri T., Tashiro M., Lim W.W.L., Guan Y., Peiris J.S.M. and Kawaoka Y., The development and characterization of H5 influenza virus vaccines derived from 1 2003 human isolate, Vaccine. 2006, 24: 3669-3676. |
|
Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen D.P.H., Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L.M., Lim W.W.L., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris J.S.M. and Uyeki T.M., New England Medical Journal, Three Indonesian clusters of h5N1 virus infection in 2005. 2007, 356(13): 1375. |
|
Researcher
: Lin Y |
|
List of Research Outputs |
|
Lin Y.,
Wang M., Di B., Zhou D.H., Jing H.Q., Liu Y.F., Wu X.W., Qin P.Z., Wang Y.L.,
Jian L.Y., Li X.Z., Xu J.X., Lu E.J., Li T.G., Xu J.G. and Zheng B., Food market with live births
as source of avian inluenza, Options for the Control of Influenza VI
Conference.. |
|
Wang M., Di B., Zhou D.H., Zheng B., Jing H., Lin Y., Liu Y.F., Wu X.W., Qin P.Z., Wang Y.L., Jian L.Y., Li X.Z., Xu J.X., Lu E.J., Li T.G. and Xu J.G., Food markets with live birds as source of avian influenza., Emerging Infectious Diseases. 2006, 12(11): 1773-1775. |
|
Researcher
: Ma S |
|
List of Research Outputs |
|
Du
L., Zhou Y., He Y., Ma S.,
Yuen K.Y., Jiang S. and Zheng B., Intranasal vaccination with
adeno-associated virus encoding the receptor-binding domain of severe acute
respiratory syndrome coronavirus S protein induces strong and prolonged
systemic and local antibodies with neutralizing activity., The American
Society for Virology 25th Annual Meeting (25th ASV).. |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Researcher
: Ma SSL |
|
List of Research Outputs |
|
Lau S.K.P., Woo P.C.Y., Fan Y.Y., Ma S.S.L., Hui W.T., Au S.Y., Chan L.L., Chan J.Y.F., Lau A.T.K., Leung K.Y., Pun T.C.T., She H.H.L., Wong C.Y., Wong L.L.L. and Yuen K.Y., Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong , Journal of Applied Microbiology. 2007, 103: 507-515. |
|
Woo P.C.Y., Teng L.L., Ma S.S.L., Lau S.K.P. and Yuen K.Y., Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis, New Microbiologica. 2007, 30: 139-146. |
|
Researcher
: Mak CK |
|
List of Research Outputs |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Ho P.L., Cheung C.L.N., Mak C.K., Tse C.W., Ng T.K., Cheung C.H.Y., Lam R., Lai R.W., Yung R.W. and Yuen K.Y., Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2007, 57(2): 145-151. |
|
Researcher
: Ng F |
|
List of Research Outputs |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
|
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
|
Researcher
: Ng IHY |
|
List of Research Outputs |
|
Zhou J., Law H.K.W., Tu W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Decreased T lymphocytes activation and Cytotoxic activity in avian influenza: an in vitro study, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 164. |
|
Zhou
J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of
chemokines and their receptors in adult and neonatal macrophages infected
with human or avian influenza viruses, Journal of Infectious Diseases.
Infectious Diseases Society of |
|
Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Interaction of mannose binding lectin with H1N1 and H5N1 influenza A viruses, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 110. |
|
Researcher
: Ng MH |
|
List of Research Outputs |
|
Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Researcher
: Ng SP |
|
Project Title: |
Monoclonal antibodies against lipopolysaccharide antigens of Salmonella and Shigella spp. |
|
Investigator(s): |
Ng SP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Initiation Programme |
|
Start Date: |
02/2001 |
|
Abstract: |
|
To characteerise a panel of monoclonal antibodies raised against the outer core region of Salamonella lipopolysaccharides (LPS). |
|
Project Title: |
Collection of
background information on the alternative faecal indicators in the
environmental waters of |
|
Investigator(s): |
Ng SP, Yam WC |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Environment Protection Department - General Award |
|
Start Date: |
06/2001 |
|
Abstract: |
|
To detect and enumerate alternative
faecal microbial indicator organisms in the environmental waters of |
|
List of Research Outputs |
|
Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
|
Leung M.K.H., Tang S.M., Lam R.C.W., Leung Y.C., Yam W.C., Ng S.P. and Vrijmoed L.L.P., Parallel-plate solar photocatalytic reactor for air purification: semi-empirical correlation, modeling and optimization, Solar Energy. Oxford, UK, Elsevier Ltd., 2006, 80: 949-955. |
|
Researcher
: Pang CM |
|
List of Research Outputs |
|
Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
|
Researcher
: Peiris JSM |
|
Project Title: |
The application of DNA arrays to characterise the avian influenza gene pool in southern China |
|
Investigator(s): |
Peiris JSM, Guan Y, Shortridge KF |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2002 |
|
Abstract: |
|
This project is a multi-institutional
collaborative study for developing a high throughput DNA array to allow
genotyping of influenza virus isolates of avian origin from Hong Kong and
applying it to characterize the influenza virus gene pool in sourthern |
|
Project Title: |
Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
|
Investigator(s): |
Peiris JSM, Guan Y |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
National Institutes of |
|
Start Date: |
04/2003 |
|
Abstract: |
|
To study influenza pandemic preparedness
in |
|
Project Title: |
Virus-cell interaction and the pathogenesis of SARS |
|
Investigator(s): |
Peiris JSM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To explore what is the biological basis for the selective attraction of macrophages to the lung; to study what immunopathological consequences follow. |
|
Project Title: |
Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
|
Investigator(s): |
Peiris JSM, Guan Y, Lau ASY, Poon LLM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To identify the viral genetic determinants responsible for the differential cytokine hyper-induction associated with H5N1/97 viruses. We have already established the role of the viral NS gene, however, a role for other viral genes has not been excluded. we hypothesize (and have preliminary evidence) that one or more other viral genes are also involved in the hyper-induction of cytokines; to determine whether the avian viral genes/gene products of H5N1/97 directly up-regulate cytokine induction or lack "immune evasion" mechanisms evolved by human influenza viruses? to determine whether the differential up-regulation of cytokines associated with H5N1/97 is also observed in human lung epithelial cells (primary bronchial epithelial cells and human lung epithelial cell lines e.g. A549 cells. |
|
Project Title: |
The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis and viral virulence |
|
Investigator(s): |
Peiris JSM, Nicholls JM, Guan Y, Poon LLM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
02/2005 |
|
Abstract: |
|
To correlate the cytokine induction phenotype with viral genotype and morphology. |
|
Project Title: |
The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
|
Investigator(s): |
Peiris JSM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
12/2005 |
|
Abstract: |
|
The global gene expression profiling of SARS-CoV infected macrophages will provide the basis for a more detailed analysis of the signaling pathways involved in subsequent studies, and may provide rational and novel therapeutic options to be devised for treating SARS. |
|
Project Title: |
Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens |
|
Investigator(s): |
Peiris JSM, Chiu SSS, Cheung CY |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
06/2006 |
|
Abstract: |
|
To divise, optimize and evaluate the Mass Tag PCR system for the rapid disgnosis for simultaneous screening of a wide spectrum of causative agents for human respiratory tract infections, including the avian influenza H5N1 and H7N7, SARS-coronavirus (SARS-CoV). Thiw will significantly facilitate better prevention, treatment and control of infectious diseases. |
|
Project Title: |
Pathogenesis, cell signaling and virus evolution of avian influenza A (H5N1) |
|
Investigator(s): |
Peiris JSM, Guan Y, Lau ASY, Nicholls JM, Chen H, Poon LLM, Lau YL, Yuen KY |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Central Allocation Vote - Group Research Project |
|
Start Date: |
06/2006 |
|
Abstract: |
|
To study the continued evolution of H5N1 influenza viruses in Vietnam and Indonesia, in the context of the ongoing studies in Hong Kong and mainland China; to define differences in cell-signaling pathways activated by avian influenza A H5N1 compared to convetional human influenza (H1N1 or H3N2) in primary human macrophages and epithelial cells; to compare the biological characteristics of H5N1 viruses from Indonesia and Vietnam to define a basis for possible differential pathogenicity for humans; investigate the biological significance of specific viral genetic mutations/changes in recent h5N1 viruses in primary human cell culture models |
|
Project Title: |
Role of
toll-like receptors and retinoic acid-inducible gene |
|
Investigator(s): |
Peiris JSM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To investigate the role of ToII-like receptors (TLR) and retinoic acid inducible gene (RIG-1) in the induction of pro-inflammatory cytokines, chemokines and interferon stimulated genes in SARS coronavirus and other coronavirus infected primary macrophages and dendritic of human and murine origin by using a) gene knock-down (siRNA); b) gene over-expression. |
|
Project Title: |
The pathogenesis
of avian influenza A H5N |
|
Investigator(s): |
Peiris JSM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
The Wellcome Trust - General Award |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Specific aims are to: 1) Characterise the influenza viral replication profiles in tissue explant (ex-vivo) cultures of nasopharyngeal biopsies and lung tissue and primary cell cultures of human macrophages and respiratory (nasopharyngeal, bronchial, alveolar) epithelium. 2) Charaterise the functional receptors for H5N1 virus on macrophages and nasopharyngeal epithelium. 3) Define the consequences of viral entry via alternative pathways including the entry of non-neutralised virus antibody complexes via the Fc and complement receptors, to determine how these pathways affects subsequent viral replication and /or innate immune responses such as cytokine/chemokine secretion. |
|
List of Research Outputs |
|
Boltz D.A., Douangngeun D., Sinthasak S., Phommachanh P., Rolston S., Chen H., Guan Y., Peiris J.S.M., Smith G.J. and Webster R.G., H5N1 influenza viruses in Lao People’s Democratic Republic, Emerging Infectious Diseases. 2006, 12: 1593-1595. |
|
Buchy P., Mardy S., Vong S., Toyoda T., Aubin J.T., Miller M., Touch S., Sovann L., Dufourcq J.B., Richner B., Tu P.V., Tien N.T., Lim W.W.L., Peiris J.S.M. and Van der Werf S., Influenza A/H5N1 virus infection in humans in Cambodia., Journal of Clinical Virology. Epub, 2007, 39(3): 164-8. |
|
Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
|
Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
|
Chan M.C.W., Chan W.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., The replication and pathogenicity of influenza A (H5N1) viruses infection in polarized human respiratory epithelium, The American Society For Virology, 25th Annual Meeting. 2006. |
|
Cheng
K.Y., Cowling B.J., Ho L.M., Peiris J.S.M., Seto W.H., Yung R., Uyeki T.M., Houck
P.M. and Leung G.M., Evaluation of
the quickvue rapid diagnostic test for influenza in a community setting
(abstract), Options for the Control of Influenza VI Conference,
17-23 June 2007, Toronto. |
|
Chiu S.S.S., Peiris J.S.M., Chan K.H., Wong W.H.S. and Lau Y.L., Immunogenicity and Safety of Intradermal Influenza Immunization at a Reduced Dose in Healthy Children, Pediatrics. 2007, 119: 1076-1082. |
|
Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
|
Cowling
B.J., Ho L.M., Peiris J.S.M., Seto W.H., Yung R. and Leung G.M., Non-pharmaceutical
interventions for influenza - A pilot study for a large cluster randomized
controlled trial in the household setting (abstract), IX International
Symposium on Respiratory Viral Infections, 3-6 March 2007, Hong Kong.
Hong Kong, |
|
Cowling
B.J., Cheng K.Y., Ho L.M., Peiris J.S.M., Seto W.H., Yung R., Uyeki T.M., Houck
P.M. and Leung G.M.,
Non-pharmaceutical interventions for influenza prevention in households - Pilot
findings of a large cluster randomized controlled trial in Hong Kong
(abstract), Options for the Control of Influenza VI Conference,
17-23 June 2007, Toronto. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
|
Guan Y., Smith G.J., Peiris J.S.M. and Webster R.G., Comments on the Fujian-like strain of avian influenza H5N1., Poult Sci. 2007, 86(3): 435-436. |
|
Horimoto T., Takada A., Fujii K., Goto H., Hatta M., Watanabe S., Iwatsuki-Horimoto K., Ito M., Tagawa-Sakai Y., Yamada S., Ito T., Imai M., Itamura S., Odagiri T., Tashiro M., Lim W.W.L., Guan Y., Peiris J.S.M. and Kawaoka Y., The development and characterization of H5 influenza virus vaccines derived from 1 2003 human isolate, Vaccine. 2006, 24: 3669-3676. |
|
Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
|
Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen D.P.H., Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L.M., Lim W.W.L., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris J.S.M. and Uyeki T.M., New England Medical Journal, Three Indonesian clusters of h5N1 virus infection in 2005. 2007, 356(13): 1375. |
|
Kung N.Y., Morris R.S., Perkins N.R., Sims L.D., Ellis T.M., Bissett L., Chow M., Shortridge K.F., Guan Y. and Peiris J.S.M., Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002., Emerging Infectious Diseases. 2007, 13(3): 412-8. |
|
Lam
E., Poon L.L.M., Zhou Y., Chye M.L. and Peiris J.S.M., Transgenic
plant-derived siRNAs: suppression of influenza virus propagation in mammalian
cells, US Patent Application No. 11/402, 181 filed April 10, 2006
[US200628921-A1 published December 14, 2006]. |
|
Lau
E.H.Y., Leung C.Y.H., Zheng L.J.,
Mak S.P., Guan Y., Leung G.M. and Peiris J.S.M., The effect of
interventions on influenza A (H9N2) isolation in Hong Kong's live poultry
markets, 1999-2005 (abstract), IX International Symposium on Respiratory
Viral Infections, 3-6 March 2007, Hong Kong. Hong Kong, |
|
Lee E.H., Chan Y.K., Nicholls J.M., Peiris J.S.M. and Khoo U.S., Sialic acid alpha-2,6-sialyltransferase (SA-alpha-2,6-Gal) Promoter Polymorphism and Gene Expression, MGH-HKU-Nature China Forum, Hong Kong. 2007. |
|
Li
O.T.W., |
|
Mok K.P., Lee D.C.W., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Differential onset of apoptosis in influenza A virus H5N1 - and H1N1 - infected human blood macrophages, Journal of General Virology. 2007, 88(Pt 4): 1275-1280. |
|
Nefkens I., Garcia J., Lagarde N.J.C., Chu S.L., Peiris J.S.M., Buchy P. and Altmeyer R.M., H5 pseudotyped lentiviral particles: A New tool for sero-diagnosis of influenza H5N1 infection, IX International Symposium on Respiratory Viral Infections. 2007. |
|
Nefkens I., Garcia J., Lagarde N.J.C., Chu S.L., Peiris J.S.M., Buchy P. and Altmeyer R.M., Hemagglutinin pseudotyped lentiviral particles: Characterization of a new tool for avian influenza H5N1 influenza serodiagnostic, Journal of clinical Virology. 2007, 39(1): 27-33. |
|
Ng M.W., Zhou G., Chong W.P., Lee W.Y., Law H.K.W., Zhang H., Wong W.H.S., Fok S.F.S., Zhai Y., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M., He F. and Lau Y.L., The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese, BMC Infectious Diseases. 2007, 7: 50. |
|
Nicholls
J.M. and Peiris J.S.M.,
The Role of a Pathology Laboratory in SARS and Other Emerging Infections, In:
|
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
|
Okada M., Okuno Y., Hashimoto S., Kita Y., Kanamaru N., Nishida Y., Tsunai Y., Inoue R., Nakatani H., Fukamizu R., Namie Y., Yamada J., Takao K., Asai R., Asaki R., Kase T., Takemoto Y., Yoshida S., Peiris J.S.M., Chen P.J., Yamamoto N., Nomura T., Ishida I., Morikawa S., Tashiro M. and Sakatani M., Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models, Vaccine. 2007, 25(16): 3038-40. |
|
Okada M., Takemoto Y., Okuno Y., Hashimoto S., Fukunaga Y., Tanaka T., Kita Y., Kuwayama S., Muraki Y., Kanamaru N., Takai H., Okada C., Sakaguchi Y., Furukawa I., Yamada K., Izumiya M., Yoshida S., Matsumoto M., Kase T., Peiris J.S.M., DeMelloo D.E., Chen P.J., Yamamoto N., Yoshinaka Y., Nomura T., Ishida I., Morikawa S., Tashiro M. and Sakatani M., Development of vaccines and passive immunotherapy against SARS coronavirus using mouse and SCID-PBL/hu mouse models, Advances in Experimental Medicine and Biology. 2006, 581: 561-6. |
|
Peiris
J.S.M., "Avian flu - a threat to human
health", The PeMSAA ( |
|
Peiris
J.S.M., 60 Years of TIME |
|
Peiris J.S.M., Antivirals: how far have we come since acyclovir?, Infectious diseases courses and postgraduate diploma programme 2004-2006: Infections in the immunocompromised hosts and common infective problems in general practice.. 2006. |
|
Peiris
J.S.M., Avian Flu - Implications for |
|
Peiris J.S.M., de Jong M.D. and Guan Y., Avian Influenza Virus (H5N1): a Threat to Human Health, Clinical Microbiology Reviews. American Society for Microbiology, 2007, April 2007: 243-267. |
|
Peiris J.S.M., CMV diseases in transplant recipients and non-transplant patients., Infectious diseases courses and postgraduate diploma programme 2004-2006: Infections in the immunocompromised hosts and common infective problems in general practice.. 2006. |
|
Peiris
J.S.M., Chairman for the Session: SARS |
|
Peiris
J.S.M., Co-chair: Translation session: Human
H5N1: Clinical finding and treatment options, |
|
Peiris
J.S.M., Current situation in avian
influenza., Emerging Zoonotic Infections: Integrating Research, Diagnosis
and Surveillance. |
|
Peiris
J.S.M., Division lecture: Pathogenesis of
Human Influenza A H5N1 disease, |
|
Peiris
J.S.M., Fellow, The Royal Society, |
|
Peiris
J.S.M., Influenza Virus and the risk of a
pandemic., 3rd Pasteur - |
|
Peiris
J.S.M., Invited Lecture: Disease Burden of
Influenza in Tropics in |
|
Peiris
J.S.M., Invited Lecture: Lessons from
previous viral outbreaks and preparations for future outbreaks, |
|
Peiris
J.S.M., Invited lecture: Avian Flu -
Implications for |
|
Peiris
J.S.M., Invited lecture: Avian flu H5N1 - A
threat to human health, |
|
Peiris
J.S.M., Invited lecture: Avian flu: is there
a threat to human health?, |
|
Peiris
J.S.M., Invited lecture: Avian influenza in
animals and humans: current situation, |
|
Peiris
J.S.M., Invited lecture: Confronting SARS and
avian flu, |
|
Peiris
J.S.M., Invited lecture: Confronting emerging
infectious diseases: avian flu and SARS, |
|
Peiris
J.S.M., Invited lecture: Confronting the
threat of avian flu, |
|
Peiris
J.S.M., Invited lecture: Disease Burden of
Influenza in the Tropics in |
|
Peiris
J.S.M., Invited lecture: H5N1 influenza and
its risk as a potential pandemic strain, |
|
Peiris
J.S.M., Invited lecture: Pathogenesis and
Immune Responses (Hong Kong / |
|
Peiris
J.S.M., Invited lecture: Pathogenesis and
origin of SARS, |
|
Peiris
J.S.M., Invited lecture: Pathogenesis of
Avian Flu, |
|
Peiris
J.S.M., Invited lecture: The ecology of H5N |
|
Peiris
J.S.M., Keynote speaker: Pathogenesis of
Zoonotic Respiratory Viral Infections: Studies in SARS and Avian Influenza , |
|
Peiris
J.S.M., Lecture: Current situation in avian
influenza, |
|
Peiris
J.S.M., Novel Coronaviruses in Bats of the
genus Miniopterus, M.Phil. thesis submitted by Mr. Daniel |
|
Peiris J.S.M., Pathogenesis of avian flu H5N1 and SARS, Novartis Foundation . Wiley, 2006, 279: 56-60. |
|
Peiris J.S.M., PhD student Ms. Chan Wan Yi, Wong Ching Yee Medical Postgraduate Scholarships 2006/2007. 2007. |
|
Peiris J.S.M., PhD student Ms. Hui Pui Yan, The Butterfield-Croucher Studentship for the best local candidate in biological and medical sciences category. 2007. |
|
Peiris J.S.M., Plenary Lecture: Emergence and pathogenesis of Avian Flu H5N1, Hong Kong. The 1st Asian Pacific Symposium on Advanced Molecular Technologies. 2006. |
|
Peiris
J.S.M., Plenary lecture: Avian flu where did
it come from where is it going to go?, |
|
Peiris J.S.M., Scientific Advisory Committee, Hong Kong. IX International Symposium on Respiratory Viral Infections. 2007. |
|
Peiris
J.S.M., Scientific Committee Member, |
|
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
|
Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Tang J.W., Cheung J.L., |
|
Tang J.W., Cheung J.L.K., |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Vichit-Vadakan N., Vajanapoom N., Ostro B., Wong C.M., Peiris J.S.M., Thach T.Q., Chau Y.K., Chan K.P., Chung R.Y.N., Thomas G.N., Lam T.H., Wong T.W., Hedley A.J., Kan H.D., Chen B.H., Zhao N.Q., Song G.X., Chen G.H., Jiang L.L., Zhang Y.H., Qian Z., He Q., Lin H.M., Kong L., Zhou D., Liao D., Liu W., Bentley C.M., Dan J., Wang B., Yang N., Xu S., Gong J., Wei H., Sun H. and Zjdian Q., Public health and air pollution in Asia (PAPA) - A multi-city study for short-term effects of air pollution on mortality (poster presentation), Health Effects Institute Annual Conference 2007, 15–17 April 2007, Chicago. Chicago, Health Effects Institute, 2007. |
|
Webster R.G., Hulse-Post D.J., Sturm-Ramirez K.M., Guan Y., Peiris J.S.M., Smith G.J. and Chen H., Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses, Avian Disease. 2007, 51: 269-272. |
|
Wong C.M., Peiris J.S.M., Thach T.Q., Chau Y.K., Chan K.P., Chung R.Y.N., Ou C., Yang L., Thomas G.N., Lam T.H., Wong T.W. and Hedley A.J., Interaction between air pollution and respiratory viruses: Time-series studies for daily mortality and hospital admissions (poster presentation), Health Effects Institute Annual Conference 2007, 15-17 April 2007, Chicago. Chicago, Health Effects Institute, 2007. |
|
Wong
C.M., Ou C., Lai H.K., Chan K.P., Thach T.Q., Yang L., Chau Y.K., Hedley A.J., Peiris J.S.M. and Lam T.H., Is physical exercise beneficial
or harmful to the health impact of influenza on mortality for the older
population?, International
Meeting on Emerging Diseases and Surveillance 2007, 23-25 February 2007,
Vienna. |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Yang
L., Wong C.M., Ou C., Chan K.P. and Peiris J.S.M., Seasonal variation of
influenza health effects in Hong Kong (abstract), International
Meeting on Emerging Diseases and Surveillance 2007, 23-25 February 2007,
Vienna. |
|
Yang
L., Wong C.M., Lau E.H.Y., Chan K.P., Ou C., Lim W.L. and Peiris J.S.M., Synchrony of
influenza virus activity and influenza-like illness in Hong Kong (abstract), Options
for the Control of Influenza VI Conference, 17-23 June 2007, Toronto.
|
|
Yang
L., Wong C.M. and Peiris J.S.M., The seasonal pattern
of influenza effects on health (asbtract), 11th Research Postgraduate
Symposium, 7 December 2006, LKS Faculty of Medicine, |
|
Yip C.W., Hon C.C., Zeng F., Chow Y.C.K., Chan K.H., Peiris J.S.M. and Leung F.C.C., Naturally Occurring Anti-Escherichia coli Protein Antibodies in the Sera of Healthy Humans Cause Analytical Interference in a Recombinant Nucleocapsid Protein-Based Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Severe Acute Respiratory Syndrome, Clinical and Vaccine Immunology. 2007, 14: 99-101. |
|
Yuen K.Y., Wong S.S.Y. and Peiris J.S.M., The severe acute respiratory syndrome, In: Fong IW, Alibek K, New and evolving infections of the 21st century. Springer, 2007, 163-193. |
|
Zeng F., Hon C.C., Yip C.W., Law K.M., Yeung Y.S., Chan K.H., Peiris J.S.M. and Leung F.C.C., Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: Implications for the functional roles of S2 subunit, Federation of European Biochemical Societies. 2006, 580: 5612-5620. |
|
Zhou J., Law H.K.W., Tu W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Decreased T lymphocytes activation and Cytotoxic activity in avian influenza: an in vitro study, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 164. |
|
Zhou
J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of
chemokines and their receptors in adult and neonatal macrophages infected
with human or avian influenza viruses, Journal of Infectious Diseases.
Infectious Diseases Society of |
|
Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Interaction of mannose binding lectin with H1N1 and H5N1 influenza A viruses, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 110. |
|
de jong M.D., Simmons C.P., Thanh T.T., Hien V.M., Smith G.J., Chau T.N., Hoang D.M., Van Vinh Chau N., Khanh T.H., Dong V.C., Qui P.T., Van Cam B., Ha D.Q., Guan Y., Peiris J.S.M., Chinh N.T., Hien T.T. and Farrar J., Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia., Nature medicine. 2006. |
|
ter Meulen J.A.N., van den Brink E. N., Poon L.L.M., Marissen W.E., Leung C.S.W., Cox F.R.E.E.K., Cheung C.Y., Bakker A. Q., Bogaards J.A., van Deventer E.L.S., Preiser W., Doerr H.W., Chow V.T., de Kruif J., Peiris J.S.M. and Goudsmit J., Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants, PLoS Medicine. 2006, 3 (7): 1071-1079. |
|
Researcher
: Poon KM |
|
List of Research Outputs |
|
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Zhang B., Wong S., Chen Y., Poon K.M., Jiang S. and Zheng B., Genetic variations of type I interferon receptor 1 promoter and their association with chronic hepatitis B virus infection., Journal of Microbes and Infection. 2007, 2(1): 19-25. |
|
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
|
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
|
Researcher
: Poon LLM |
|
Project Title: |
Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome |
|
Investigator(s): |
Poon LLM, Guan Y |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To generate a coronavirus-like mini vRNA GFP (green fluorescent protein) reporter system to study the transcription and replication of coronavirus; to establish a reverse genetic system of coronavirus. |
|
Project Title: |
Roles of segment-specific vRNA sequences of influenza A virus in viral replication, transcription and gene expression |
|
Investigator(s): |
Poon LLM, Guan Y, Peiris JSM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To establish a GFP reporter assay for influenza replication studies; to determine the potential function of segment-specific viral RNA sequences in viral replication, tansporation and gene expression; to study the 5' and 3' segment-specific regions of avian, human and swine influenza. |
|
Project Title: |
Splicing of influenza A virus |
|
Investigator(s): |
Poon LLM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To study the sequence requirements for the splicing of influenza viral mRNA; to study the role of splicing in controlling viral protein expression; to generate recombinant influenza viruses with mutations in the splicing sequences and determine the global effects of mutations in these regions in an influenza life cycle; to test whether there is a host-specific selective pressure on the 5' splicing site of influenza mRNA. |
|
Project Title: |
Development of one-step reverse trasncriptase-loop mediated isothermal amplification for direct detections of H5N1 and human influenza viruses |
|
Investigator(s): |
Poon LLM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2006 |
|
Abstract: |
|
Introduction A diagnosis of influenza A
virus could be made by classical methods such as virus isolation,
haemagglutinin inhibition test, antigen detection and serology. In the last
decade, the rapid advancement of molecular techniques has opened up a new
horizon for clinical diagnosis of influenza virus. Molecular techniques, such
as PCR, mutliplex PCR, real-time PCR and nucleic acid sequence-based
amplification (NASBA) are shown to be useful for clinical applications. These
molecular techniques are demonstrated to be highly sensitive and specific.
More importantly, most of the above molecular tests could produce diagnostic
results in a very short period of time, thereby making these molecular
approaches become attractive tools for rapid diagnosis of influenza viruses.
These molecular tests, however, often require sophisticated equipment,
expensive reagents and highly skilled personnel. Thus, these rapid molecular
tests might not be the method of choice in basic clinical settings in
developing countries or in field situations. The recent invention of
loop-mediated isothermal amplification (LAMP) has opened up a new horizon for
molecular diagnosis (1). Briefly, this method depends on auto-cycling strand
displacement DNA synthesis performed by a Bst DNA polymerase. The reaction
relies on recognition of the target sequence by six independent sequences in
the initial stage and by four independent sequences during the later stages
of the LAMP reaction, thereby making this kind of assays to be highly
specific. The amplification products are stem-loop DNA structures with
several inverted repeats of the target and form cauliflower-like structures
with multiple loops. This approach is extreme rapid and has DNA amplification
efficiency equivalent to that of PCR-based methods (1). More importantly,
this approach is extreme simple and all reactions are performed in an
isothermal environment. Furthermore, no special apparatus is needed, which
makes it more economical and practical than nested PCR or real-time PCR.
These advantages make LAMP become very applicable in very basic healthcare/field
settings. Recently, using the LAMP approach, we developed several molecular
assays for detecting cDNA from several pathogens (2-4). In these previous
studies, the performances of these assays were at least comparable to routine
molecular diagnostic tests. More importantly, we successfully used this
technology for a direct detection DNA of Plasomodium falciparum in
heat-treated blood (5). More importantly, our modifications of the assays
could reduce the reagent cost to as low as 2 HK dollars per test (5). We
expect the low running cost of this detection approach would be an attractive
option for molecular diagnosis. However, our modified technology still cannot
be used for a direct detection of RNA species in clinical samples. The recent
outbreaks of H5 influenza viruses in |
|
Project Title: |
Studies of mammalian, avian and chimeric influenza polymerase complexes |
|
Investigator(s): |
Poon LLM |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To determine the transcription and replication profiling of influenza viruses with avian, mammalian, or mammalian-avian chimeric polymerase complexes in human and avian cells; to test the compatibility between avian and mammalian influenza polymerase subunits; to identify the important residues in avian PB2, PB1 and PA for host adaptation; to determine the PB2-PB1 and PB1-PA interactions in mammalian-avian chimeric complexes; to identify the host factors that might interact with viral polymerase complexes for viral transcription and replication. |
|
List of Research Outputs |
|
Cheung K.W. and Poon L.L.M., Biology of influenza a virus, ANNUALS of the New York Academy of Sciences. 2007, 1102: 1-25. |
|
Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
|
Jayawardena S., Cheung C.Y., Barr I., Chan K.H., Chen H., Guan Y., Peiris J.S.M. and Poon L.L.M., Loop-mediated isothermal amplification for influenza A (H5N1) virus., Emerging Infectious Diseases. 2007, 13(6): 899-901. |
|
Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen D.P.H., Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L.M., Lim W.W.L., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris J.S.M. and Uyeki T.M., New England Medical Journal, Three Indonesian clusters of h5N1 virus infection in 2005. 2007, 356(13): 1375. |
|
Lam
E., Poon L.L.M., Zhou Y., Chye M.L. and Peiris J.S.M., Transgenic plant-derived
siRNAs: suppression of influenza virus propagation in mammalian cells, US
Patent Application No. 11/402, 181 filed April 10, 2006 [US200628921-A1
published December 14, 2006]. |
|
Li O.T.W.,
|
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
|
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
|
Poon
L.L.M., Avian influenza virus - from surveillance
to diagnosis, Applied Biosystems, |
|
Poon
L.L.M. and Cheung
K.W., Biology of influenza A virus, |
|
Poon L.L.M., Pandemic concern of avian H5N1 influenza viruses, “Characterization and Management of Emerging Viral Diseases in the Developing World'', International Centre for Genetic Engineering and Biotechnology, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan. . 2006. |
|
Poon L.L.M., Recent Patents on DNA and Gene Sequences. 2007. |
|
Poon L.L.M., SARS and other coronaviruses in humans and animals. , Adv Exp Med Biol. . 2006, 581: 457-62. |
|
Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
de Souza Luna L.K., Heiser V., Regamey N., Panning M., Drexler J.F., Mulangu S., Poon L.L.M., Baumgarte S., Haijema B.J., Kaiser L. and Drosten C., Generic detection of coronaviruses and differentiation at the prototype strain level by RT-PCR and non-fluorescent low density microarray., J Clin Microbiol. . 2007, 45: 1049-52. |
|
ter Meulen J.A.N., van den Brink E.N., Poon L.L.M., Marissen W.E., Leung C.S.W., Cox F.R.E.E.K., Cheung C.Y., Bakker A.Q., Bogaards J.A., van Deventer E.L.S., Preiser W., Doerr H.W., Chow V.T., de Kruif J., Peiris J.S.M. and Goudsmit J., Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants, PLoS Medicine. 2006, 3 (7): 1071-1079. |
|
Researcher
: Poon RWS |
|
List of Research Outputs |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Qin K |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Researcher
: Rayner JM |
|
List of Research Outputs |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Zhang
J., Zhang Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian Influenza
Virus Receptors And H5n1 Virus Infection In Human Respiratory Tract, The
Options For The Control Of Influenza Vi June 17-23, Toronto, Ontario, Canada.
|
|
Researcher
: Seto WH |
|
List of Research Outputs |
|
Chan K.H., Lam S.Y., Puthavathana P., Nguyen T.D., Long H.T., Pang C.M., Chan K.M., Cheung C.Y., Seto W.H. and Peiris J.S.M., Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1, Journal of Clinical Virology. 2007, 38(2): 169-71. |
|
Cheng
K.Y., Cowling B.J., Ho L.M., Peiris J.S.M., Seto W.H., Yung R., Uyeki T.M., Houck
P.M. and Leung G.M., Evaluation of
the quickvue rapid diagnostic test for influenza in a community setting
(abstract), Options for the Control of Influenza VI Conference,
17-23 June 2007, Toronto. |
|
Cowling
B.J., Ho L.M., Peiris J.S.M., Seto W.H., Yung R. and Leung G.M., Non-pharmaceutical
interventions for influenza - A pilot study for a large cluster randomized
controlled trial in the household setting (abstract), IX International
Symposium on Respiratory Viral Infections, 3-6 March 2007, Hong Kong.
Hong Kong, |
|
Cowling
B.J., Cheng K.Y., Ho L.M., Peiris J.S.M., Seto W.H., Yung R., Uyeki T.M., Houck
P.M. and Leung G.M.,
Non-pharmaceutical interventions for influenza prevention in households -
Pilot findings of a large cluster randomized controlled trial in Hong Kong
(abstract), Options for the Control of Influenza VI Conference,
17-23 June 2007, Toronto. |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Tsang K.W.T., Shim Y.S., Wong K.S., Laim C.K., Eng P., Lam W.K. and Seto W.H., Possible case scenarios an logistic issues in H5N1 pandemic, Respirology. 2006, 11(5): 520-522. |
|
Xie X., Li Y., Chwang A.T.Y., Ho P.L. and Seto W.H., How far droplets can move in indoor environments – Revisiting Wells evaporation-falling curve of droplets., Indoor Air. 2007, 17 (3): 211-225. |
|
Researcher
: Shiu SYW |
|
Project Title: |
sPDZD2-induced protein profile changes in prostate cancer |
|
Investigator(s): |
Shiu SYW, |
|
Department: |
Physiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To express and purify sPDZD |
|
Project Title: |
Overexpression
of sPDZD |
|
Investigator(s): |
Shiu SYW, |
|
Department: |
Physiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2005 |
|
Abstract: |
|
PDZ (PSD95, Discs-large, and ZO-1) domain containing protein 3 (PDZK3), also known as PDZ domain containing protein 2 (PDZD2), is a ubiquitously expressed protein of unknown function which has six PDZ domains. The protein is cleaved in a caspase-dependent mechanism to generate a secreted protein (sPDZD2), which may participate in extracellular signaling [Yeung et al. 2003, EMBO Rep 4: 412]. Interestingly, gene expression of PDZK3 has been reported to be upregulated in prostate cancer when compared with benign tissues Thus, it is believed that PDZK3, also named as activated in prostate cancer protein (AIPC), may play an important role in prostate tumorigenesis [Chaib et al. 2001, Cancer Res 61:2390]. Given that our ongoing studies have demonstrated that sPDZD2 protein is produced and secreted by human prostate cancer cell lines, we would like to postulate that sPDZD2 protein, a cleavage product of PDZD2, may play an important role in prostate cancer pathogenesis by modulating prostate cancer cell growth and differentiation. The objectives of this proposal are to 1) over-express sPDZD2 protein in prostate cancer cells, and 2) to study any effect of the protein on the expression of cell cycle and apoptosis-related proteins in the transfected cancer cells. |
|
Project Title: |
Structure-function studies of sPDZD2 protein and identification of its cellular targets |
|
Investigator(s): |
Shiu SYW, |
|
Department: |
Physiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Globally, prostate cancer has become the
third most common cancer in men, with half a million new cases each year,
amounting to about 10% of all male cancers. It is the most common cancer
after skin cancer, and is the second leading cause of cancer-related death in
men in the |
|
List of Research Outputs |
|
Researcher
: Shortridge KF |
|
List of Research Outputs |
|
Kung N.Y., Morris R.S., Perkins N.R., Sims L.D., Ellis T.M., Bissett L., Chow M., Shortridge K.F., Guan Y. and Peiris J.S.M., Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002., Emerging Infectious Diseases. 2007, 13(3): 412-8. |
|
Researcher
: Smith GJ |
|
List of Research Outputs |
|
Bahl
J., Dhanasekaran V., Smith G.J., Webster R.G. and Guan Y., Evolutionary dynamics of avian
influenza A virus in the natural reservoir, Options for the control of
influenza VI, |
|
Boltz D.A., Douangngeun D., Sinthasak S., Phommachanh P., Rolston S., Chen H., Guan Y., Peiris J.S.M., Smith G.J. and Webster R.G., H5N1 influenza viruses in Lao People’s Democratic Republic, Emerging Infectious Diseases. 2006, 12: 1593-1595. |
|
Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
|
Guan
Y., Zhong N.S., Chen H., Smith G.J. and Zheng B., An averted SARS outbreak, In:
JCK Chan, VCW Taam Wong, Challenges of Severe Acute Respiratory Syndrome.
|
|
Guan Y., Smith G.J., Peiris J.S.M. and Webster R.G., Comments on the Fujian-like strain of avian influenza H5N1., Poult Sci. 2007, 86(3): 435-436. |
|
Guan Y., Field H., Smith G.J. and Chen H., SARS coronavirus: An animal reservoir?, In: JSM Peiris, LJ Anderson,ADME Osterhaus, K Stohr, KY Yuen, Severe Acute Respiratory Syndrome. Blackwell Publishing, 2006, 79-83. |
|
Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
|
Smith
G.J., Career Development Award (US$1,000,509)
for research into the ecology, evolution and population genetics of influenza
A (H5N1) virus. Awarded by |
|
Smith
G.J., Ecology and evolution of H5N1 influenza
in southern |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Smith
G.J., Evolution of H5N1 avian influenza:
Evidence from the field, First African Symposium on Avian and Pandemic
Influenza, International Consortium on Antivirals, |
|
Smith G.J., Dhanasekaran V., Chen H. and Guan Y., Positive selection on the H5N1 Influenza virus genome, 25th Annual Meeting – American Society of Virology, University of Wisconsin. 2006. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
|
Webster R.G., Hulse-Post D.J., Sturm-Ramirez K.M., Guan Y., Peiris J.S.M., Smith G.J. and Chen H., Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses, Avian Disease. 2007, 51: 269-272. |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
de jong M.D., Simmons C.P., Thanh T.T., Hien V.M., Smith G.J., Chau T.N., Hoang D.M., Van Vinh Chau N., Khanh T.H., Dong V.C., Qui P.T., Van Cam B., Ha D.Q., Guan Y., Peiris J.S.M., Chinh N.T., Hien T.T. and Farrar J., Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia., Nature medicine. 2006. |
|
Researcher
: Song W |
|
List of Research Outputs |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Researcher
: Sui H |
|
List of Research Outputs |
|
Sui H.,
Wong K.L., Huang J. and Zheng B., Long term expression of small
interfering RNA targeting M2 gene induces effective inhibition of influenza A
virus replication. , Options for the Control of Influenza VI Conference..
|
|
Researcher
: Tai H |
|
List of Research Outputs |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Researcher
: Tang X |
|
List of Research Outputs |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Researcher
: Teng LL |
|
Project Title: |
Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci |
|
Investigator(s): |
Teng LL, Woo PCY, Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To study usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci. |
|
List of Research Outputs |
|
Lau S.K.P., Teng L.L., Leung K.W., Li N.K., Ng K.H., Chau K.Y., Que T.L., Woo P.C.Y. and Yuen K.Y., Bacteremia caused by Solobacterium moorei in a patient with acute proctitis and carcinoma of the cervix , Journal of clinical microbiology. 2006, 44(8): 3031-3034. |
|
Lau
S.K.P., Woo P.C.Y., Fan Y.Y., Lee R.C.M., Teng L.L. and Yuen K.Y., Seasonal and tissue
distribution of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis,
in retail freshwater fish in |
|
Woo P.C.Y., Teng L.L., Ma S.S.L., Lau S.K.P. and Yuen K.Y., Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis, New Microbiologica. 2007, 30: 139-146. |
|
Woo P.C.Y., Chung M.W.C., Teng L.L., Tse H., Pang S.S.Y., Lau V.Y.T., Wong V.W.K., Kam K., Lau S.K.P. and Yuen K.Y., In silico analysis of 16S ribosomal RNA gene sequencing-based methods for identification of medically important anaerobic bacteria, Journal of Clinical Pathology. 2006, 60: 576-579. |
|
Researcher
: Tsang DNC |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Researcher
: Tse H |
|
Project Title: |
Phenotypic and
genotypic characterization of Helcococcus isolates in |
|
Investigator(s): |
Tse H, Woo PCY, Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To perform phenotypic and molecular
characterization on the Helcococcus isolates from patients in |
|
Project Title: |
Characterization of genes horizontally transferred from prokaryotes to Penicillium marneffei |
|
Investigator(s): |
Tse H, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To study the pattern of horizontal gene transfer from prokaryotes to the fungus Penicillium marneffei and perform genetic and phylogenetic characterizations of the transferred genes, which would provide useful information about its natural habitat and its ecology in the natural environment |
|
List of Research Outputs |
|
Woo P.C.Y., Chung M.W.C., Teng L.L., Tse H., Pang S.S.Y., Lau V.Y.T., Wong V.W.K., Kam K., Lau S.K.P. and Yuen K.Y., In silico analysis of 16S ribosomal RNA gene sequencing-based methods for identification of medically important anaerobic bacteria, Journal of Clinical Pathology. 2006, 60: 576-579. |
|
Researcher
: Tsoi HW |
|
List of Research Outputs |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Wang J |
|
List of Research Outputs |
|
Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Wang J., Smith G.J., Li K.S., Duan L., Dhanasekaran V., Chen H. and Guan Y., Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China, Options for the control of influenza VI, Toronto, Canada.. 2007. |
|
Researcher
: Wang P |
|
List of Research Outputs |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Researcher
: Wang TKF |
|
List of Research Outputs |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Wang T.K.F., Yuen K.Y. and Wong S.S.Y., Penicillium marneffei fungemia in an HIV-infected patient., International journal of infectious diseases. 2006. |
|
Researcher
: Webster RG |
|
List of Research Outputs |
|
Bahl
J., Dhanasekaran V., Smith G.J., Webster R.G. and Guan Y., Evolutionary dynamics of avian
influenza A virus in the natural reservoir, Options for the control of
influenza VI, |
|
Boltz D.A., Douangngeun D., Sinthasak S., Phommachanh P., Rolston S., Chen H., Guan Y., Peiris J.S.M., Smith G.J. and Webster R.G., H5N1 influenza viruses in Lao People’s Democratic Republic, Emerging Infectious Diseases. 2006, 12: 1593-1595. |
|
Dhanasekaran V., Smith G.J., Bahl J., Wang J., Webster R.G. and Guan Y., Dating the emergence of influenza A (H5N1) viruses, Options for the control of influenza VI, Toronto, Canada, 2007. |
|
Guan Y., Smith G.J., Peiris J.S.M. and Webster R.G., Comments on the Fujian-like strain of avian influenza H5N1., Poult Sci. 2007, 86(3): 435-436. |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Webster R.G., Hulse-Post D.J., Sturm-Ramirez K.M., Guan Y., Peiris J.S.M., Smith G.J. and Chen H., Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses, Avian Disease. 2007, 51: 269-272. |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Researcher
: Wong BHL |
|
List of Research Outputs |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Researcher
: Wong KC |
|
List of Research Outputs |
|
Yam W.C., Lam T.H., Wong K.C., Yuen K.Y. and Ho P.L., Differential gene expression associated with phenotypic virulence of Mycobacterium tuberculosis, In: Keystone Symposia, Keystone Symposia - Tuberculosis : From Lab Research to Field Trials. 2007. |
|
Researcher
: Wong KH |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Lu W., Zheng
B., Xu K., Schwarz W., Du L.,
Wong K.H., Chen J., Duan S.,
Deubel V. and Sun B., Severe acute respiratory syndrome-associated
coronavirus |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Researcher
: Wong KL |
|
List of Research Outputs |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Sui
H., Wong K.L., Huang J. and Zheng B., Long term expression of small
interfering RNA targeting M2 gene induces effective inhibition of influenza A
virus replication. , Options for the Control of Influenza VI Conference..
|
|
Researcher
: Wong SSY |
|
Project Title: |
Molecular characterization of streptococcus bovis bacteraemia |
|
Investigator(s): |
Wong SSY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To characterize 48 S. bovis strains isolated from the blood cultures of 37 bacteraemic patients over a six-year period using a combination of phenotypic and genotypic techniques. The epidemiology, underlying diseases, clinical disease associations, and outcome of S. bovis bacteraemia in relation to the different biotypes and genotypes of S. bovis will be investigated, and the molecular epidemiology of erythromycin resistance in the S. bovis strains will also be analyzed. |
|
Project Title: |
Screening antigenic proteins in penicillium marneffei for seroepidemiology and vaccination |
|
Investigator(s): |
Wong SSY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To screen for yeast- and mould-phase-specific antigens that are useful for epidemiological and diagnostic purposes; to screen for yeast-phase- and mould-phase-specific antigens that induce active immunity against penicilliosis marneffei from normalized cDNA libraries of the two phases of the dimorphic fungus; to construct a prophylactic and/or therapeutic vaccine prototype; to study the seroepidemiology of penicilliosis marneffei. |
|
Project Title: |
Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification |
|
Investigator(s): |
Wong SSY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To use the state-of-the-art molecular technique for bacterial identification, 16S rRNA gene sequencing, to characterize these bacterial isolates. Novel bacterial species discovered will be further characterized. |
|
Project Title: |
Phenotypic and genotypic characterization of Streptococcus iniae isolates in Hong Kong |
|
Investigator(s): |
Wong SSY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To perform phenotypic and molecular
characterization on the Streptococcus iniae isolates from patients in |
|
List of Research Outputs |
|
Ho P.L. and Wong S.S.Y., Reducing bacterial resistance with IMPACT-Interhospital Multi-disciplinary Program on Antimicrobial Chemotherapy., In: Ho PL, Wong SSY (ed.), 2006, 3: 1-124. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S.S.Y., Chrysomya bezziana: a rare infestation of the breast., The Breast Journal. 2007, 13: 297-301. |
|
Mok
T.M.Y., Wong S.S.Y., Chan D.T.M., Fong D.Y.T., Wong R.W.S. and Lau W.C.S., Non-tuberculous
mycobacterial infection in patients with systemic lupus erythematosus, Rheumatology.
|
|
Mok T.M.Y., Wong S.S.Y., Chan D.T.M., Fong D.Y., Wong R.W.S. and Lau W.C.S., Non-tuberculous mycobacterial infection in patients with systemic lupus erythematosus, Rheumatology (Oxford). 2007, 46: 280-284. |
|
Tiwari A.F.Y., Tarrant A.M., Yuen K.H., Chan S.S.C., Ching P., Wong A. and Wong S.S.Y., Preparedness for influenza pandemic in Hong Kong nursing units., Journal of Nursing Scholarship. 2006, 38: 308-313. |
|
To K.K., Cheng V.C.C., Hung I.F.N., Tang B.S., Wong S.S.Y. and Yuen K.Y., Caecal-caecal intussusception caused by Trichuris trichiura in a young healthy adult., Scandinavian Journal of Infectious Diseases. 2006, 38: 813-815. |
|
Wang T.K.F., Yuen K.Y. and Wong S.S.Y., Asymptomatic Penicillium marneffei fungemia in an HIV-infected patient., International Journal of Infectious Diseases. 2007, 11: 280-281. |
|
Wang T.K.F., Yam W.C., Yuen K.Y. and Wong S.S.Y., Misidentification of a mucoid strain of Salmonella enterica serotype choleraesuis as Hafnia alvei by the Vitek GNI+ card system., Journal of Clinical Microbiology. 2006, 44: 4605-4608. |
|
Wang T.K.F., Wong C.F., Au W.K., Cheng V.C.C. and Wong S.S.Y., Mycobacterium tuberculosis sternal wound infection after open heart surgery: a case report and review of the literature, Diagnostic Microbiology and Infectious Disease. Elsevier, 2007, 58: 245-249. |
|
Wang T.K.F., Yuen K.Y. and Wong S.S.Y., Penicillium marneffei fungemia in an HIV-infected patient., International journal of infectious diseases. 2006. |
|
Wang T.K.F. and Wong S.S.Y., Streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever?, BMC Infectious Diseases. BioMed Central, 2007, 7: 56-62. |
|
Wong S.S.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Bats as a continuing source of emerging infections in humans., Reviews in Medical Virology. 2007, 17: 67-91. |
|
Wong S.S.Y., Ho P.L. and Yuen K.Y., Evolution of antibiotic resistance mechanism and its relevance to dialysis-related infection, Peritoneal Dialysis International. Multimed Inc., 2007, 27 (Supplement 2): S272-S285. |
|
Wong S.S.Y. and Yuen K.Y., Zoonotic potential of emerging animal diseases., British Medical Journal. 2006, 331: 1260. |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Yuen K.Y., Wong S.S.Y. and Peiris J.S.M., The severe acute respiratory syndrome, In: Fong IW, Alibek K, New and evolving infections of the 21st century. Springer, 2007, 163-193. |
|
Researcher
: Woo GKS |
|
List of Research Outputs |
|
Lau S.K.P., Woo P.C.Y., Woo G.K.S., Fung A.M.Y., Ngan A.H.Y., Song Y., Liu C., Summanen P., Finegold S.M. and Yuen K.Y., Bacteraemia caused by Anaerotruncus colihominis and emended description of the species, Journal of Clinical Pathology. 2006, 59: 748-752. |
|
Lau S.K.P., McNabb A., Woo G.K.S., Hoang L., Fung A.M.Y., Chung L.M.W., Woo P.C.Y. and Yuen K.Y., Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada, Journal of Clinical Microbiology. 2007, 45: 395-401. |
|
Researcher
: Woo PCY |
|
Project Title: |
Molecular epidemiology of erythromycin resistant [beta]-hemolytic Lancefield group G streptococci causing bacteremia |
|
Investigator(s): |
Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To perform phenotypic and genotypic characterization of the erythromycin resistance in [beta]-hemolytic group G streptococci recovered from blood cultures of patients in a six-year period. Risk factors for bacteremia caused by [beta]-hemolytic group G streptocci will also be analyzed. |
|
Project Title: |
The origin of antibiotic resistance genes: a genome based phylogentic analysis |
|
Investigator(s): |
Woo PCY, Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Completion Date: |
10/2006 |
|
Abstract: |
|
To perform a genome based in silico analysis to determine the reason for antibiotic resistance genes in actinomycetes being the "origins" of some antibiotic resistance genes. |
|
Project Title: |
The role of a novel bacterium, Laribacter hongkongensis, in gastroenteritis, and its epidemiology and pathogenesis |
|
Investigator(s): |
Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To study the association of L. hongkongensis with gastroenteritis in humans and the epidemiology of this novel disease entity; to provide clinicians with appropriate treatment regimen by correlation of antibiotic susceptibilities and clinical outcome; to discover the source and reservoir of the bacterium; to define its pathogenesis in terms of toxin production, tissue and animal invasiveness. |
|
Project Title: |
Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important anaerobic bacteria |
|
Investigator(s): |
Woo PCY, Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To study usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important anaerobic bacteria. |
|
Project Title: |
A prospective
study on the epidemiology of coronavirus-associated respiratory tract
infections in |
|
Investigator(s): |
Woo PCY, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
12/2005 |
|
Abstract: |
|
The present study will generate valuable information for understanding the prevalence, the clinical spectrum of disease and epidemiology of the different coronaviruses in all age groups, and in turn their public health significance and economic implications, as compared to other respiratory viral pathogens. Rapid tests useful for the detection of the various coronaviruses from clinical specimens will also be developed. |
|
Project Title: |
Characterization of an unidentified gram-positive bacillus recovered from surgical site abscess of a patient with carcinoma of oesophagus. |
|
Investigator(s): |
Woo PCY, Lau SKP, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
The objective of this study is to characterize an unidentified gram-positive bacillus recovered from the surgical abscess of a patient. |
|
List of Research Outputs |
|
Cai J., Woo P.C.Y., Lau S.K.P., Smith D.K. and Yuen K.Y., Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota., Journal of molecular evolution. 2006, 63(1): 1-11. |
|
Lam K.Y., Tai K.K., Koo M.W.L., Wong P.S.H., Wu K.K., So H.L., Woo P.C.Y. and Cho C.H., Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG, Life Sciences. Elsevier, 2007, 80: 2128-2136. |
|
Lau S.K.P., Woo P.C.Y., Woo G.K.S., Fung A.M.Y., Ngan A.H.Y., Song Y., Liu C., Summanen P., Finegold S.M. and Yuen K.Y., Bacteraemia caused by Anaerotruncus colihominis and emended description of the species, Journal of Clinical Pathology. 2006, 59: 748-752. |
|
Lau S.K.P., Teng L.L., Leung K.W., Li N.K., Ng K.H., Chau K.Y., Que T.L., Woo P.C.Y. and Yuen K.Y., Bacteremia caused by Solobacterium moorei in a patient with acute proctitis and carcinoma of the cervix , Journal of clinical microbiology. 2006, 44(8): 3031-3034. |
|
Lau S.K.P., McNabb A., Woo G.K.S., Hoang L., Fung A.M.Y., Chung L.M.W., Woo P.C.Y. and Yuen K.Y., Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada, Journal of Clinical Microbiology. 2007, 45: 395-401. |
|
Lau S.K.P., Woo P.C.Y., Fan Y.Y., Ma S.S.L., Hui W.T., Au S.Y., Chan L.L., Chan J.Y.F., Lau A.T.K., Leung K.Y., Pun T.C.T., She H.H.L., Wong C.Y., Wong L.L.L. and Yuen K.Y., Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong , Journal of Applied Microbiology. 2007, 103: 507-515. |
|
Lau
S.K.P., Woo P.C.Y., Fan Y.Y., Lee R.C.M., Teng L.L. and Yuen K.Y., Seasonal and tissue
distribution of Laribacter hongkongensis, a novel bacterium associated with
gastroenteritis, in retail freshwater fish in |
|
Wong S.S.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Bats as a continuing source of emerging infections in humans., Reviews in Medical Virology. 2007, 17: 67-91. |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Woo
P.C.Y., Bat as a continuing source of
emerging infections, The 11th SCBA International Symposium ( |
|
Woo P.C.Y., Teng L.L., Ma S.S.L., Lau S.K.P. and Yuen K.Y., Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis, New Microbiologica. 2007, 30: 139-146. |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Woo
P.C.Y., Coronavirus HKU1, a novel human
coronavirus, Emerging infection disease workshop ( |
|
Woo P.C.Y., Editorial Board member, Hong Kong Medical Journal, 2007. |
|
Woo P.C.Y., Chung M.W.C., Teng L.L., Tse H., Pang S.S.Y., Lau V.Y.T., Wong V.W.K., Kam K., Lau S.K.P. and Yuen K.Y., In silico analysis of 16S ribosomal RNA gene sequencing-based methods for identification of medically important anaerobic bacteria, Journal of Clinical Pathology. 2006, 60: 576-579. |
|
Woo
P.C.Y., Laribacter hongkongensis genome, HKU-UBC
Workshop on Emerging Infectious Diseases ( |
|
Woo P.C.Y., Molecular epidemiology, genotypes and recombination of coronavirus HKU1, a novel human coronavirus associated with respiratory tract infection, 17th European Congress of Clinical Microbiology and Infectious Diseases. 2007. |
|
Woo
P.C.Y., Outstanding Young Researcher Award
2005-2006, The |
|
Woo P.C.Y., Lau S.K.P., Lin A.W.C., Curreem S.O.T., Fung A.M.Y. and Yuen K.Y., Surgical site abscess caused by Lactobacillus fermentum identified by 16S ribosomal RNA gene sequencing , Diagnostic Microbiology and Infectious Disease. 2007, 58: 251-254. |
|
Woo
P.C.Y., Updates on coronavirus HKU1, IX
International Symposium on Respiratory Viral Infections ( |
|
Researcher
: Wu HW |
|
List of Research Outputs |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
|
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
|
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
|
Researcher
: Xu K |
|
List of Research Outputs |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
|
Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Researcher
: Yam WC |
|
List of Research Outputs |
|
Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Ha W.Y., Lau C.C., Yue P.Y., Hung K.K., Chan K., Chui S.H., Chui A.K., Yam W.C. and Wong R.N., Simultaneous detection of precore/basal core promoter mutations in hepatitis B virus using arrayed primer extension , Molecular Diagnosis and Therapy. 2006, 10(2): 125-134. |
|
Ho P.L., Wang T.K.F., Ching P.T.Y., Mak C.K., Lai E.L.Y., Yam W.C. and Seto W.H., Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong, Infection Control and Hospital Epidemiology. 2007, 28(6): 671-8. |
|
Lam H.Y., Chen H.K.J., Wong K.H., Chan K., Li P., Lee M.P., Tsang D.N., Yuen K.Y. and Yam W.C., Evaluation of NucliSens EasyQ™ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia , In: Elsevier, Journal of Clinical Virology. Elsevier, 2006, 38: 39-43. |
|
Lau C.C., Yue P.A.T.R.I.C.K., Chui S.H., Chui A.L.B.E.R.T., Yam W.C. and Wong R.I.C.K.Y., Detection of single nucleotide polymorphisms in hepatitis B virus precore/basal core promoter region by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry , In: Elsevier, Analytical Biochemistry 366 (1), pp. 93-95 . Elsevier, 2007, 366(1): 93-95. |
|
Leung K.H., Yip S.P., Wong W.S., Yiu
L.S., Chan K.K., Lai W.M., Chow Y.D., Lin C.K., Yam W.C. and Chan K.S., Sex- and
age-dependent association of SLC |
|
Leung M.K.H., Tang S.M., Lam R.C.W., Leung Y.C., Yam W.C., Ng S.P. and Vrijmoed L.L.P., Parallel-plate solar photocatalytic reactor for air purification: semi-empirical correlation, modeling and optimization, Solar Energy. Oxford, UK, Elsevier Ltd., 2006, 80: 949-955. |
|
Wang T.K.F., Yam W.C., Yuen K.Y. and Wong S.S.Y., Misidentification of a mucoid strain of Salmonella enterica serotype choleraesuis as Hafnia alvei by the Vitek GNI+ card system., Journal of Clinical Microbiology. 2006, 44: 4605-4608. |
|
Yam W.C., Lam T.H., Wong K.C., Yuen K.Y. and Ho P.L., Differential gene expression associated with phenotypic virulence of Mycobacterium tuberculosis, In: Keystone Symposia, Keystone Symposia - Tuberculosis : From Lab Research to Field Trials. 2007. |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Researcher
: Yip CY |
|
List of Research Outputs |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Project Title: |
Establishment of core facilities for the HKU HIV/AIDS research laboratories |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Council for the AIDS Trust Fund - General Award |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To support the development of state-of-art clinical management of HIV/AIDS founded on scientific research and clinical trials; to undertake research for expanding the knowledge base on HIV molecular epidemiology in Hong Kong and the reigon; to examine the immunological mechanisms underlying HIV pathogenesis; to study AIDS associated infectious diseases; to build expertise in HIV molecular biology and immunology. |
|
Project Title: |
Molecular characterization of Streptococcus milleri causing infective endocarditis |
|
Investigator(s): |
Yuen KY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To identify members of the "S. milleri group" in patients with infective endocarditis by 16S rRNA gene sequencing; to define the epidemiology, clinical spectrum, treatment, and outcome of infective endocarditis associated with the "S. milleri group". |
|
Project Title: |
An oral mucosal DNA vaccine for SARS coronavirus infections |
|
Investigator(s): |
Yuen KY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
09/2004 |
|
Abstract: |
|
To test the feasibility of using the live-attenuated Salmonella system for delivery of DNA vaccine of the spike protein of SARS-CoV in mice, and compare the immunogenicity of oral DNA vaccine, naked DNA vaccine, and recombinant protein vaccine. |
|
Project Title: |
Characterization of a novel bacterial genus and species, Anaerospora hongkongensis gen. nov.sp.nov., isolated from the blood culture of a patient |
|
Investigator(s): |
Yuen KY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Completion Date: |
10/2006 |
|
Abstract: |
|
To characterize a novel bacterial genus and species using various phenotypic and genotypic techniques; to understad its evolutional relationship to other related bacterial genus and species. |
|
Project Title: |
Characterisation of local/emerging pathogens and development of anti-infective agents |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
05/2005 |
|
Abstract: |
|
There are 4 categories of pathogens are selected to compete with the rest of the world and therefore advance the research of our University to top international level: hepatitis B virus (HBV), Laribacter Hongkongenesis, influenze A virus and novel oral pathogens. |
|
Project Title: |
The role of a novel coronavirus, coronavirus HKU1, in respiratory illness and its epidemiology and molecular evolution |
|
Investigator(s): |
Yuen KY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
07/2005 |
|
Abstract: |
|
To study the role of CoV-HKU |
|
Project Title: |
Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To characterize a strain of Anaerotruncus
colihominis recovered from the blood culture of a patient in |
|
Project Title: |
Wild animal
surveillance for coronavirus HKU1, a novel coronavirus associated with
pneumonia in patients in |
|
Investigator(s): |
|
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
12/2005 |
|
Abstract: |
|
The present study is going to yield valuable information for understanding the reservoir of coronavirus HKU1 and potential variants of other coroanviruses that infect human, which is crucial for the control of respiratory tract infections associated with the viruses. |
|
Project Title: |
A multilocus sequence typing system for Penicillum marneffei: an international molecular cyber system for tracking the origin and transmission of Penicillium marneffei |
|
Investigator(s): |
Yuen KY, Woo PCY, Lau SKP |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2006 |
|
Abstract: |
|
In this project, using the sequence data of the Penicillium marneffei Genome Project, we propose to build up a multilocus sequence typing (MLST) system, for this fungus. |
|
List of Research Outputs |
|
Cai J., Woo P.C.Y., Lau S.K.P., Smith D.K. and Yuen K.Y., Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota., Journal of molecular evolution. 2006, 63(1): 1-11. |
|
Chan C.P., Siu K.L., Chin K.T., Yuen K.Y., Zheng B. and Jin D., Modulation of the unfolded protein response by severe acute respiratory syndrome coronavirus spike protein., Journal of Virology. 2006, 80: 9279-9287. |
|
Che X.Y., Di B., Zhao G.P., Wang Y.D., Qiu L.W., Hao W., Wang M., Qin P.Z., Liu Y.F., Chan K.H., Cheng V.C.C. and Yuen K.Y., A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China. , Clinical infectious diseases. 2006, 43(1): e1-e5. |
|
Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Cheung W.W., Tse E.W.C., Leung A.Y.H., Yuen K.Y. and Kwong Y.L., Regular virologic surveillance showed very frequent cytomegalovirus reactivation in patients treated with alemtuzumab, Blood. 2007, 82(2): 108-11. |
|
Chu K.W., Poon L.L.M., Chan K.H., Chen H., Guan Y., Yuen K.Y. and Peiris J.S.M., Coronaviruses in bent-winged bats (Miniopterus supp.), Journal of General Virology. 2006, 87: 2461-2466. |
|
Du
L., Zhou Y., He Y., Ma S., Yuen K.Y., Jiang S. and Zheng B., Intranasal vaccination with
adeno-associated virus encoding the receptor-binding domain of severe acute
respiratory syndrome coronavirus S protein induces strong and prolonged
systemic and local antibodies with neutralizing activity., The American
Society for Virology 25th Annual Meeting (25th ASV).. |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Ho P.L., Cheung C.L.N., Mak C.K., Tse C.W., Ng T.K., Cheung C.H.Y., Lam R., Lai R.W., Yung R.W. and Yuen K.Y., Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2007, 57(2): 145-151. |
|
Lam H.Y., Chen H.K.J., Wong K.H., Chan K., Li P., Lee M.P., Tsang D.N., Yuen K.Y. and Yam W.C., Evaluation of NucliSens EasyQ™ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia , In: Elsevier, Journal of Clinical Virology. Elsevier, 2006, 38: 39-43. |
|
Lau S.K.P., Woo P.C.Y., Woo G.K.S., Fung A.M.Y., Ngan A.H.Y., Song Y., Liu C., Summanen P., Finegold S.M. and Yuen K.Y., Bacteraemia caused by Anaerotruncus colihominis and emended description of the species, Journal of Clinical Pathology. 2006, 59: 748-752. |
|
Lau S.K.P., Teng L.L., Leung K.W., Li N.K., Ng K.H., Chau K.Y., Que T.L., Woo P.C.Y. and Yuen K.Y., Bacteremia caused by Solobacterium moorei in a patient with acute proctitis and carcinoma of the cervix , Journal of clinical microbiology. 2006, 44(8): 3031-3034. |
|
Lau S.K.P., McNabb A., Woo G.K.S., Hoang L., Fung A.M.Y., Chung L.M.W., Woo P.C.Y. and Yuen K.Y., Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada, Journal of Clinical Microbiology. 2007, 45: 395-401. |
|
Lau S.K.P., Woo P.C.Y., Fan Y.Y., Ma S.S.L., Hui W.T., Au S.Y., Chan L.L., Chan J.Y.F., Lau A.T.K., Leung K.Y., Pun T.C.T., She H.H.L., Wong C.Y., Wong L.L.L. and Yuen K.Y., Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong , Journal of Applied Microbiology. 2007, 103: 507-515. |
|
Lau
S.K.P., Woo P.C.Y., Fan Y.Y., Lee R.C.M., Teng L.L. and Yuen K.Y., Seasonal and tissue
distribution of Laribacter hongkongensis, a novel bacterium associated with
gastroenteritis, in retail freshwater fish in |
|
Leung A.Y.H., Chow C.H., Kwok J.S.Y., Lui C.K., Cheng V.C.C., Yuen K.Y., Lie A.K.W. and Liang R.H.S., Safety of vacinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2007, 39(11): 661-5. |
|
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
|
To K.K., Cheng V.C.C., Hung I.F.N., Tang B.S., Wong S.S.Y. and Yuen K.Y., Caecal-caecal intussusception caused by Trichuris trichiura in a young healthy adult., Scandinavian Journal of Infectious Diseases. 2006, 38: 813-815. |
|
Wang T.K.F., Yuen K.Y. and Wong S.S.Y., Asymptomatic Penicillium marneffei fungemia in an HIV-infected patient., International Journal of Infectious Diseases. 2007, 11: 280-281. |
|
Wang T.K.F., Yam W.C., Yuen K.Y. and Wong S.S.Y., Misidentification of a mucoid strain of Salmonella enterica serotype choleraesuis as Hafnia alvei by the Vitek GNI+ card system., Journal of Clinical Microbiology. 2006, 44: 4605-4608. |
|
Wang T.K.F., Yuen K.Y. and Wong S.S.Y., Penicillium marneffei fungemia in an HIV-infected patient., International journal of infectious diseases. 2006. |
|
Wong A.S.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Kwong Y.L. and Leung A.Y.H., Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation, Clinical Infectious Disease. 2007, 44(6): 830-837. |
|
Wong S.S.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Bats as a continuing source of emerging infections in humans., Reviews in Medical Virology. 2007, 17: 67-91. |
|
Wong S.S.Y., Ho P.L. and Yuen K.Y., Evolution of antibiotic resistance mechanism and its relevance to dialysis-related infection, Peritoneal Dialysis International. Multimed Inc., 2007, 27 (Supplement 2): S272-S285. |
|
Wong S.S.Y. and Yuen K.Y., Zoonotic potential of emerging animal diseases., British Medical Journal. 2006, 331: 1260. |
|
Woo P.C.Y., Chong T.K., Lau C.Y., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., A novel approach for screening immunogenic proteins in Penicillium marneffei using the DeltaAFMP1DeltaAFMP2 deletion mutant of Aspergillus fumigatus. , FEMS microbiology letters. 2006, 262(2): 138-147. |
|
Woo P.C.Y., Teng L.L., Ma S.S.L., Lau S.K.P. and Yuen K.Y., Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis, New Microbiologica. 2007, 30: 139-146. |
|
Woo P.C.Y., Lau S.K.P., Yip C.Y., Huang Y., Tsoi H.W., Chan K.H. and Yuen K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. , Journal of virology. 2006, 80(14): 7136-7145. |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Woo P.C.Y., Chung M.W.C., Teng L.L., Tse H., Pang S.S.Y., Lau V.Y.T., Wong V.W.K., Kam K., Lau S.K.P. and Yuen K.Y., In silico analysis of 16S ribosomal RNA gene sequencing-based methods for identification of medically important anaerobic bacteria, Journal of Clinical Pathology. 2006, 60: 576-579. |
|
Woo P.C.Y., Lau S.K.P., Lin A.W.C., Curreem S.O.T., Fung A.M.Y. and Yuen K.Y., Surgical site abscess caused by Lactobacillus fermentum identified by 16S ribosomal RNA gene sequencing , Diagnostic Microbiology and Infectious Disease. 2007, 58: 251-254. |
|
Xu H., Di B., Pan Y.X., Qiu L.W., Wang Y.D., Hao W., He L.J., Yuen K.Y. and Che X.Y., Serotype 1-specific monoclonal antibody-based antigen capture immunoassay for detection of circulating nonstructural protein NS1: Implications for early diagnosis and serotyping of dengue virus infections. , Journal of clinical microbiology. 2006, 44(8): 2872-2878. |
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Yam W.C., Lam T.H., Wong K.C., Yuen K.Y. and Ho P.L., Differential gene expression associated with phenotypic virulence of Mycobacterium tuberculosis, In: Keystone Symposia, Keystone Symposia - Tuberculosis : From Lab Research to Field Trials. 2007. |
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Yuen K.Y., Wong S.S.Y. and Peiris J.S.M., The severe acute respiratory syndrome, In: Fong IW, Alibek K, New and evolving infections of the 21st century. Springer, 2007, 163-193. |
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Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
|
Researcher
: Zhang H |
|
List of Research Outputs |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Researcher
: Zhang J |
|
List of Research Outputs |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of Coronaviruses, Journal of Virology. 2007, 81: 4012-4020. |
|
Dhanasekaran V., Smith G.J., Zhang J., Peiris J.S.M., Chen H. and Guan Y., Evolutionary insights into the ecology of coronaviruses , 5th Asia-Pacific Bioinformatics Conference, Hong Kong, China. 2007. |
|
Smith G.J., Fan X., Wang J., Li K., Qin K., Zhang J., Dhanasekaran V., Cheung C.L., Huang K., Rayner J.M., Peiris J.S.M., Chen H., Webster R.G. and Guan Y., Emergence and predominance of an H5N1 influenza variant in China, Proceedings of the National Academy of Sciences USA. 10/2006, 2006, 103: 16936–16941. |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Tang X., Zhang J., Zhang S.Y., Wang P., Fan X.H., Li L., Li G., Dong B.Q., Liu W., Cheung C.L., Xu K., Song W., Dhanasekaran V., Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H. and Guan Y., Prevalence and genetic diversity of coronaviruses in bats from China, Journal of Virology. 2006, 80(15): 7481-7490. |
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Xu K., Smith G.J., Li J.W., Tai H., Zhang J., Webster R.G., Peiris J.S.M., Chen H. and Guan Y., Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005, Journal of Virology. 2007, 81: 2635-2645. |
|
Zhang
J., Zhang
Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian Influenza
Virus Receptors And H5n1 Virus Infection In Human Respiratory Tract, The
Options For The Control Of Influenza Vi June 17-23, Toronto, Ontario, Canada.
|
|
Researcher
: Zhang L |
|
List of Research Outputs |
|
Smith G.J., Naipospos T.S., Nguyen T.D., de Jong M.D., Dhanasekaran V., Usman T.B., Hassan S.S., Nguyen T.V., Dao T.V., Bui N.A., Leung C.Y.H., Cheung C.L., Rayner J.M., Zhang J., Zhang L., Poon L.L.M., Li K., Nguyen V.C., Hien T.T., Farrar J., Webster R.G., Chen H., Peiris J.S.M. and Guan Y., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam, Virology. 2006, 350(2): 258-68. |
|
Researcher
: Zhang Z |
|
List of Research Outputs |
|
Zhang
J., Zhang Z., Fang X., Huang K., Rayner J.M., Ng W.F., Li K.S., Guan Y. and Chen H., Expression Of Avian Influenza
Virus Receptors And H5n1 Virus Infection In Human Respiratory Tract, The
Options For The Control Of Influenza Vi June 17-23, Toronto, Ontario, Canada.
|
|
Researcher
: Zhao G |
|
List of Research Outputs |
|
Du L., Zhao G., He Y., Guo Y., Zheng B., Jiang S. and Zhou Y., Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model., Vaccine. 2007, 25(15): 2832-2838. |
|
Researcher
: Zhao X |
|
List of Research Outputs |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Researcher
: Zheng B |
|
Project Title: |
The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults |
|
Investigator(s): |
Zheng B, Lee SS |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Council for the AIDS Trust Fund - General Award |
|
Start Date: |
01/2001 |
|
Abstract: |
|
To determine the prevalence of the major
forms of CCR5 promoter and CCR2 polymorphism in healthy Chinese adults; to
compare the pattern between healthy adults and HIV infected individuals in |
|
Project Title: |
CCR5 expression on antigen-presenting cens in HIV infection |
|
Investigator(s): |
Zheng B, Lee SS |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Council for the AIDS Trust Fund - General Award |
|
Start Date: |
01/2001 |
|
Abstract: |
|
To describe the pattern of CCR5 expression on APC in HIV infection; to correlate this pattern to HIV infected APC; to determine the functional and/or quantitative deficiency in CCR5 expressing APC. |
|
Project Title: |
Studies of SARS virus vaccines |
|
Investigator(s): |
Zheng B, Guan Y |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2005 |
|
Abstract: |
|
The study objectives are developments of an inactivated vaccine and a cold attenuated live vaccine. |
|
Project Title: |
A preliminary study on the inhibition of avian infuenza virus H5N1 replication using siRNA |
|
Investigator(s): |
Zheng B |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
1. Study purposes Searching for effective
and specific antiviral agents against H5N1 avian flu is one of the world-wide
top priorities in influenza research. Our project aims to assess the
feasibility of using RNAi to inhibit the replication of H5N1 virus in cell
cultures. 2. Key issues (1) The first outbreak of H5N1 avian flu in Hong Kong
in 1997 and its re-emergence in Southeast Asian since 2004 have afflicted
>125 patients and claimed >60 lives. Although the number of patients
was limited and there was no evidence that the virus can efficiently transmitted
from human to human, the recent outbreaks have suggested that the virus has
the potential to trigger a pandemic. (2) The pathology of H5N1 avian flu is
poorly understood. To day, no effective and specific treatment for this
highly pathogenic disease has been recommended yet. Therefore, development of
effective therapeutics and specific vaccination to combat H5N1 avian flu has
become a worldwide effort. The high pathogenicity of H5N1 still causes
problems and safety concerns for vaccine development. (3) RNAi is effective
for inhibition of viral replication. However, it is not known whether the
highly pathogenic H5N1 may have evolved to express anti-RNAi proteins or
RNAs. Our and others’ pilot studies have demonstrated that siRNAs targeting
PA, NP and M2 genes of H5N1 virus can effectively inhibit viral replication.
The current proposal is a logical extension of these studies. (4) The roles
of the other 3 structural (H, N & M1) and 5 non-structural (PB2, PB1, NS1
& NS2) genes of H5N |
|
Project Title: |
A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R) |
|
Investigator(s): |
Zheng B, Lu L, Chan KW |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Council for the AIDS Trust Fund - General Award |
|
Start Date: |
07/2006 |
|
Abstract: |
|
To define and confirm the specificities of viral gene mutations in non-B subtypes of HIV-1 that are responsible for drug resistance, identify potential drug-resistance before treatment failure, and analyze the circumstances for the causation of latent infection by drug-resistant viruses. |
|
Project Title: |
A feasibility study on the inhibition of avian infuenza virus H5N1 replication using siRNA |
|
Investigator(s): |
Zheng B, |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) Rational design and evalution of additional siRNAs targeting multiple structural and non-structural genes of H5N1 virus in cultured cells; (2) analysis of the synergistic antiviral effects of different siRNAs obtained; (3) development of effective non-viral and viral based systems for delivering H5N1-targeting siRNAs in mice and evaluation of the antiviral effects of selective siRNAs in vivo. |
|
Project Title: |
A novel anti-H5N1 avian influenza virus agent using silver nano-particle |
|
Investigator(s): |
Zheng B, Yuen KY, Che CM, Tam PKH, Huang J |
|
Department: |
Microbiology |
|
Source(s) of Funding: |
Guangdong-Hong Kong Technology Cooperation Funding Scheme |
|
Start Date: |
03/2007 |
|
Abstract: |
|
To optimize size and conformation of silver nanoparticle to reach the hoghest effectiveness for anti-H5N1 viral infection in cell culutre system. To study underlying mechanism of silver nanoparticle in inhibiting H5N1 viral infection. To investigate the prophylactic and therapeutic effects of silver nanoparticle in the H5N1 viral infection in an animal model. To evaluate the safety of silver nanoparticle for prevention and treatment in animal models. |
|
List of Research Outputs |
|
Chan C.P., Choi W.Y.J., Cao K., Wang M., Gao Y., Zhou D.H., Di B., Xu H.F., Leung M.F., Bergmann A., Lehmann M., Nie Y.M., Cautherley G.W., Fuchs D., Renneberg R. and Zheng B., Detection of serum neopterin for early assessment of dengue virus infection., Journal of Infection. 2006, 53(3): 152-158. |
|
Chan C.P., Siu K.L., Chin K.T., Yuen K.Y., Zheng B. and Jin D., Modulation of the unfolded protein response by severe acute respiratory syndrome coronavirus spike protein., Journal of Virology. 2006, 80: 9279-9287. |
|
Chen H.K.J., Wong K.H., Chan K., Lam H.Y., Lee S.S., Li P., Lee M.P., Tsang D.N., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping , In: Elsevier, Journal of Clinical Virology. Elsevier, 2007, 39: 125-131. |
|
Chen H.K.J., Wong K.H., Chan K.C.W., Lam H.Y., Lee S.S., Li P.C.K., Lee M.P., Tsang D.N.C., Zheng B., Yuen K.Y. and Yam W.C., Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping., J Clin Virol.. 2007, 39(2): 125-131. |
|
Du
L., Zhou Y., He Y., Ma S., Yuen K.Y., Jiang S. and Zheng B., Intranasal vaccination
with adeno-associated virus encoding the receptor-binding domain of severe
acute respiratory syndrome coronavirus S protein induces strong and prolonged
systemic and local antibodies with neutralizing activity., The American
Society for Virology 25th Annual Meeting (25th ASV).. |
|
Du L., Zhao G., He Y., Guo Y., Zheng B., Jiang S. and Zhou Y., Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model., Vaccine. 2007, 25(15): 2832-2838. |
|
Du L., He Y., Wang Y., Zhang H., Ma S., Wong K.L., Wu H.W., Ng F., Huang J., Yuen K.Y., Jiang S., Zhou Y. and Zheng B., Strong antigenicity and neutralizing antibody induced by recombinant Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines., Vorology. 2006, 353(1): 6-16. |
|
Guan
Y., Zhong N.S., Chen H., Smith G.J. and Zheng B., An averted SARS outbreak,
In: JCK Chan, VCW Taam Wong, Challenges of Severe Acute Respiratory
Syndrome. |
|
Lam Q.L.K., Lo C.K., Zheng B., Ko K.H., Osmond D.G., Wu G.E., Rottapel R. and Lu L., Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice., International Immunology. 2007, 19(3): 267-76. |
|
Lin
Y., Wang M., Di B., Zhou D.H., Jing H.Q., Liu Y.F., Wu X.W., Qin P.Z.,
Wang Y.L., Jian L.Y., Li X.Z., Xu J.X., Lu E.J., Li T.G., Xu J.G. and Zheng B., Food market with live
births as source of avian inluenza, Options for the Control of Influenza
VI Conference.. |
|
Lu W., Zheng B., Xu K., Schwarz W., Du L., Wong K.H., Chen J., Duan S., Deubel V.
and Sun B., Severe acute respiratory syndrome-associated coronavirus |
|
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
|
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
|
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
|
Sui
H., Wong K.L., Huang J. and Zheng B., Long term expression of
small interfering RNA targeting M2 gene induces effective inhibition of
influenza A virus replication. , Options for the Control of Influenza VI
Conference.. |
|
Sun H., Yang N., Ge R. and Zheng B., Interactions of antimony and bismuth with biomolecules: implications for the mechanism of action, 7th International Conference on Environmental and Biological Aspects of Main-Group Organometallics (7th ICEBAMO), Heraklion, Crete, Greece, October 10- 12. 2006. |
|
Wang M., Di B., Zhou D.H., Zheng B., Jing H., Lin Y., Liu Y.F., Wu X.W., Qin P.Z., Wang Y.L., Jian L.Y., Li X.Z., Xu J.X., Lu E.J., Li T.G. and Xu J.G., Food markets with live birds as source of avian influenza., Emerging Infectious Diseases. 2006, 12(11): 1773-1775. |
|
Woo
P.C.Y., Wang M., Lau S.K.P., Xu
H.F., Poon R.W.S., Guo R.T., Wong B.H.L., Gao K., Tsoi H.W., Huang Y., Li K.S.M., Lam S.F., Chan K.H., Zheng B. and Yuen K.Y., Comparative analysis of
twelve genomes of three novel group |
|
Yang N., Tanner J.A., Huang J., Zheng B. and Sun H., Inhibition of SARS Coronavirus by Bismuth Compounds, 3rd Asian Biological Inorganic Chemistry Conference, Nanjing, P.R. China, October 30- November 3. 2006. |
|
Yao X., Zheng B., Zhou J., Xu D.Z., Zhao K., Sun S.H., Yuan Z.H. and Wen Y.M., Hepatitis B surface antigen-antibody complex reverted immune tolerance in chronic hepatitis B patients via modulating dendritic cells., Vaccine. 2007, 25(10): 1771-1779. |
|
Yuen R.M.F., Wong D.K.H., Zheng B., Chan C.C.S., Yuen J.C.H., Wong B.C.Y. and Lai C.L., Difference in T Helper Responses During Hepatitis Flares in HBeAg-positive Patients with Genotypes B and C: Implication for Early HBeAg Seroconversion, Journal of Viral Hepatitis. 2007, 14: 269-275. |
|
Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y., Ng M.H. and Zheng B., Functional analysis of naturally occuring mutations on open reading frame of CCR5 among HIV infected Chinese patients and the healthy controls., Journal of Microbes and Infection. 2006, 1(4): 200-206. |
|
Zheng
B., HBsAg-HBIg complex modulates antigen
presentation of dendritic cells from chronic hepatitis B patients, 12th
International Symposium on Viral Hepatitis and Liver Diseases.. |
|
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Mutational Analysis of HIV-1 Co-receptors and Their Ligands in Chinese Population. , 18th Annual ASHM Conference.. Melbourne, Australia., 2006. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C., Yuen K.Y. and Ng M.H., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , 1st International Symposium on Geneticand Immune Correlates of HIV Infection and Vaccine-Induced Immunity.. 2007. |
|
Zheng B., Zhao X., Lee S.S., Wong K.H., Chan K.C.W., Ng F., Chan C.S., Yam W.C. and Yuen K.Y., Polymorphisms of HIV-1 Co-receptors and Their Ligands in Chinese Population and the Effects on HIV-1 Infection and the Disease Progression. , Keystone Symposia: Molecular and Cellular Determinants of HIV Pathogenesis (X8).. Whistler Resort, Whistler, British Colum, 2007. |
|
Zhou J., Lu L., Zhang B., Wong S., Chen Y., Poon K.M., Jiang S. and Zheng B., Genetic variations of type I interferon receptor 1 promoter and their association with chronic hepatitis B virus infection., Journal of Microbes and Infection. 2007, 2(1): 19-25. |
|
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
|
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
|
Researcher
: Zhou J |
|
List of Research Outputs |
|
Yao X., Zheng B., Zhou J., Xu D.Z., Zhao K., Sun S.H., Yuan Z.H. and Wen Y.M., Hepatitis B surface antigen-antibody complex reverted immune tolerance in chronic hepatitis B patients via modulating dendritic cells., Vaccine. 2007, 25(10): 1771-1779. |
|
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses.. Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Zhang B., Wong S., Chen Y., Poon K.M., Jiang S. and Zheng B., Genetic variations of type I interferon receptor 1 promoter and their association with chronic hepatitis B virus infection., Journal of Microbes and Infection. 2007, 2(1): 19-25. |
|
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases.. Paris, France., 2006. |
|
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
|
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
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