DEPT OF DIAGNOSTIC RADIOLOGY

Researcher : Chan HLH

List of Research Outputs

 

Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Researcher : Chan KS

List of Research Outputs

 

Chan K.S., Mak H.K.F., Ngan S.S.C., Kwong D.L.W. and Khong P.L., Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification, SNM 2008 Annual Meeting, New Orleans, L.A., U.S.A., 14-18 June 2008.

 

Researcher : Chau MT

List of Research Outputs

 

Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007.

 

Researcher : Cheung SCW

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007.

 

Hwang Y.Y., Fan K., Lam Y.M., Chan W.S., Cheung S.C.W., Wang E.P. and Au W.Y., Primary cardiac lymphoma presenting with right heart mass and bradycardia, Annals of Hematology. 2007, 86(9): 685-6.

 

Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007.

 

Researcher : Chiu SSH

List of Research Outputs

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, 2nd Joint Scientific Meeting of the Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, 27-28 October 2007, Hong Kong. 2007.

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, Best Poster Award at 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. 2007.

 

Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Researcher : Ho WY

List of Research Outputs

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Huang B

List of Research Outputs

 

Huang B. and Khong P.L., Evaluation of radiation dose and cancer risk induced by adult whole body CT scan, 12th Research Postgraduate Symposium, The University of Hong Kong, 12th & 14th December 2007.

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose and cancer risk induced by adult whole body PET-CT scan, The American Roentgen Ray Society (ARRS) 108th Annual Meeting, Washington DC, USA, 12-18 April 2008.

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose in adult whole body PET-CT scanning , 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.. 2007.

 

Researcher : Khong PL

Project Title:

To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies

Investigator(s):

Khong PL, Cheung PT

Department:

Diagnostic Radiology

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/2002

 

Abstract:

To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone.

 

Project Title:

Whole body magnetic resonance (MR) screening in primary plasmacytomas

Investigator(s):

Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas.

 

Project Title:

Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury

Investigator(s):

Khong PL, Kwong DLW, Chan GCF

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Treatment-induced neurotoxicity is prevalant and impacts significantly on the lives of childhood brain tumour survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to be the major contributory factor that causes these deficits (Johnson et al., 1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that white matter is predisposed to radiation-induced injury and that it may be the substrate of neurocognitive deterioration. There is emerging evidence that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is sensitive in detecting and monitoring white matter injury in these patients. (Khong et al., 2005b; Khong et al., 2003; Khong et al., 2005a; Leung et al., 2004b). We aim to explore and describe an optimal method to map whole brain radiation dose distribution to the FA images of childhood brain tumour survivors.

 

Project Title:

Whole body MR imaging of bone marrow in children with Acute Lymphoblastic Leukemia (ALL): evaluation of its role in diagnosis, treatment monitoring and response prediction.

Investigator(s):

Khong PL, Chan GCF, Kwong DLW

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

We aim to determine the role of whole body MRI, a relatively new technique in MRI, in the evaluation of the bone marrow in children with acute lymphoblastic leukaemia (ALL). MRI is the most sensitive technique for the detection of bone marrow pathologies and has become the method of choice for bone marrow imaging. However, prior to the advent of whole body MRI, imaging the marrow has been restricted to selected areas of the bony skeleton because of long imaging times. Recent advances in MRI, particularly the development of fast imaging sequences have significantly reduced imaging times so that the whole body can now be imaged in 15-30 mins without compromising image quality. These advances have led to novel clinical applications of whole body MRI, including tumour staging. To date, there are no reports which have evaluated the role of this new technique in ALL. ALL is the most common tumour in children accounting for about 30% of all newly diagnosed childhood cancer patients. In Hong Kong, there are approximately 40-50 new ALL patients per year. Whole body MRI provides a means for screening the marrow of the entire skeleton, such that the full extent of disease and treatment complications can be evaluated. This is especially important in haematologic disorders which may be spatially heterogeneous like ALL. In a longitudinal study of children diagnosed with ALL, we aim to determine:1)Whole body MRI patterns at diagnosis and subsequent treatment2)If disease load/extent quantified by whole body MRI will contribute to patient management for treatment monitoring and response prediction3)The role of whole body MRI in the screening of early AVN (secondary aim)We hypothesize that this non-invasive technique will provide complementary information to conventional ways of diagnosis and monitoring treatment response i.e. peripheral blood sampling and bone marrow aspiration.We expect to be able to define the clinical usefulness of whole body MRI in leukemia patients. This method of imaging is increasingly available in MRI scanners and especially advantageous in paediatric patients whereby a non-invasive, fast, one-stop imaging modality is desirable

 

Project Title:

Diffusion tensor MRI imaging (DTI) of radiation-induced white matter injury in a rat model

Investigator(s):

Khong PL, Wu EX, Cheung PT, Kwong DLW

Department:

Diagnostic Radiology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

To test the following hypotheses: (1) diffusion anisotropy quantitative index, fractional anisotropy (FA) is more sensitive than T2 relaxometry in detecting radiation-induced white matter damage; FA and the diffusion tensor matrix components, radial diffusivity and axial diffusivity, correlate with histological findings of radiation-induced injury, namely demyelination; changes in diffusion anisotropy are dose and time dependent and occur in parallel with histological evidence of demyelination; DTI can accurately detect and monitor the degree of demyelination in-vivo and can be used as a biomarker for the non-invasive evaluation of radiation-induced brain injury.

 

List of Research Outputs

 

Au W.Y., Lo S.H., Law W.L., Khong P.L., Shek T.W.H., Lau W.H. and Chan E.M.C., Concomitant EBER+ve lymphomatoid papulosis and malignant transformation of colonic polyposis in a heart transplant recipient, Journal of Heart and Lung Transplantation. 2008, 27: 575-576.

 

Auyeung K.M., Khong P.L., Mak H.K.F. and Chan G.C.F., Unilateral germinoma in the basal ganglia: computed tomography and magnetic resonance imaging findings, Journal of the Hong Kong College of Radiologists . 2008, 11: 24-27.

 

Chan K.S., Mak H.K.F., Ngan S.S.C., Kwong D.L.W. and Khong P.L., Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification, SNM 2008 Annual Meeting, New Orleans, L.A., U.S.A., 14-18 June 2008.

 

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, 2nd Joint Scientific Meeting of the Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, 27-28 October 2007, Hong Kong. 2007.

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, Best Poster Award at 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. 2007.

 

Chow K.C., Chan G.C.F., Khong P.L., Shek T.W.H., Ha S.Y. and Lau Y.L., Primary Ki-1-positive anaplastic large cell lymphoma of the bone presented with spinal cord compression, Hong Kong Journal of Paediatrics. 2007, 12: 283-286.

 

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilic factors do not increase central venous catheter blockage in Chinese children with malignancy, Pediatr Blood & Cancer (Epub June 2008). 2008.

 

Huang B. and Khong P.L., Evaluation of radiation dose and cancer risk induced by adult whole body CT scan, 12th Research Postgraduate Symposium, The University of Hong Kong, 12th & 14th December 2007.

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose and cancer risk induced by adult whole body PET-CT scan, The American Roentgen Ray Society (ARRS) 108th Annual Meeting, Washington DC, USA, 12-18 April 2008.

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose in adult whole body PET-CT scanning , 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.. 2007.

 

Khong P.L., Advances in paediatric cancer imaging, 41st Singapore-Malaysia Congress of Medicine, Singapore, 19-22 July 2007. 2007.

 

Khong P.L., Annals of Neurology, Journal Reviewer. 2008.

 

Khong P.L., Clinical Cancer Research, Journal Reviewer. 2008.

 

Khong P.L., Clinical applications of Diffusion tensor imaging in Paediatrics, 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance Imaging in Medicine (ISMRM), Toronto, Canada, 3-9 May 2008. 2008.

 

Khong P.L., DTI in neurotoxicity, Invited lecture at Stanford University, U.S.A., 1 May 2008. 2008.

 

Khong P.L., DTI in the paediatric brain, Invited lecture at Stanford University, U.S.A., 1 May 2008. 2008.

 

Khong P.L., Diffusion tensor MR imaging in treatment induced neurotoxicity, East-West Alliance (EWA) Meeting representing HKU, Cambridge, U.K., 3-4 April 2008. 2008.

 

Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and antural killer cell malignancies, 10th International Conference on Malignant Lymphoma, Lugano, Switzerland, 4-7 June 2008.

 

Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21.

 

Khong P.L., Human Brain Mapping, Journal Reviewer. 2008.

 

Khong P.L., Imaging of paediatric abdominal emergencies, STAR courses in Thailand and Malaysia, 17-24 January 2008. 2008.

 

Khong P.L., Imaging the neonatal brain, STAR courses in Thailand and Malaysia, 17-24 January 2008. 2008.

 

Khong P.L., Journal of Pediaatric Gastroenterology and Nutrition, Journal Reviewer. 2008.

 

Khong P.L., Neonatal brain MR imaging, Scientific Meeting organized by Department of Paediatric and Adolescent Medicine, HKU, 3 Nov 2007. 2007.

 

Khong P.L., PET-CT imaging of lymphomas, 15th Hong Kong International Cancer Congress (HKICC), Hong Kong, 12-14 Nov 2008. 2008.

 

Khong P.L., PET-CT imaging workshop, STAR courses in Thailand and Malaysia, 17-24 January 2008. 2008.

 

Khong P.L., PET/CT in paediatric cancers, Joint Scientific Meeting of the RCR & HKCR and 15th Annual Scientific Meeting of the HKCR, Hong Kong, 27-28 Oct 2007. 2007.

 

Khong P.L., Pediatric Radiology, Editorial Board. 2008.

 

Khong P.L., Pediatric Radiology, Journal Reviewer. 2008.

 

Khong P.L., Pediatric Research, Journal Reviewer. 2008.

 

Khong P.L., Sir Patrick Mansion Gold Medal, Outstanding merit in thesis for degree of MD by The University of Hong Kong. 2007.

 

Khong P.L., The Hong Kong Journal of Paediatrics, Journal Reviewer. 2008.

 

Khong P.L., The Hong Kong Medical Journal, Journal Reviewer. 2008.

 

Khong P.L., The Journal of the Hong Kong College of Radiologists, Associate Editor. 2007.

 

Khong P.L., The Journal of the Hong Kong College of Radiologists, Journal Reviewer. 2007.

 

Khong P.L., The Open Medical Imaging Journal. Editorial Board. . 2007.

 

Khong P.L., Update on imaging paediatrics cancers, STAR courses in Thailand and Malaysia, 17-24 January 2008. 2008.

 

Lam D.S.T., Khong P.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Reversible encephalopathy induced by systemic high dose methotrexate, Hong Kong Journal of Paediatrics (new series). 2007, 12: 287-292.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481.

 

Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Qiu D., Ngan S.S.C., Tan L.H., Chan A.H., Mak H.K. and Khong P.L., Brain connectivity during the processing of nouns and verbs: a dynamic Bayesian network analysis, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:28). 2008.

 

Qiu D., Tan L.H., Zhou K. and Khong P.L., Diffusion Tensor Imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development, 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance Imaging in Medicine (ISMRM), Toronto, Canada, 3-9 May 2008.

 

Qiu D., Tan L.H., Zhou K. and Khong P.L., Diffusion Tensor Imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development, NeuroImage. Elsevier Inc., 2008, 14: 223-232.

 

Qiu D., Siok W.T., Tan L.H. and Khong P.L., Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Qiu D., Kwong D.L.W., Chan G.C., Leung L.H. and Khong P.L., Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity?, Int J Radiat Oncol Biol Phys. 2007, 69(3): 846-51.

 

Tan L.H., Chan H.D., Kay P., Khong P.L., Yip L. and Luke K.K., Language affects patterns of brain activation associated with perception, Proc Natl Acad Sci USA. 2008, 105: 4004-4009.

 

Wang S., Wu E.X., Tam C.N., Lau H.F., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wang S., Tse H.F., Khong P.L. and Ooi C.G.C., High prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients, RSNA 93rd Scientific Assembly and Annual Meeting, Chicago, U.S.A., 25-30 November 2007.

 

Wang S., Tam C.N., Wu E.X., Lau H.F., Qiu D., Leung L.H.T. and Khong P.L., Longitudinal diffusion tensor MR imaging study of radiation induced white matter damage in a rat model, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3268). 2008.

 

Wang S., Wu E.X., Tam C.N. and Khong P.L., Mild hypoxic-ischemic brain injury in neonatal rats using diffusion tensor MR imaging: a longitudinal study, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada,3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3298). 2008.

 

Yang J., Khong P.L., Wang Y., Chu A.C.Y., Ho S.L., Cheung P.T. and Wu E.X., Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury, Magnetic Resonance in Medicine. 2008, 59: 1329.

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Kwok SPF

List of Research Outputs

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose and cancer risk induced by adult whole body PET-CT scan, The American Roentgen Ray Society (ARRS) 108th Annual Meeting, Washington DC, USA, 12-18 April 2008.

 

Huang B., Law M.W.M., Kwok S.P.F. and Khong P.L., Evaluation of radiation dose in adult whole body PET-CT scanning , 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.. 2007.

 

Researcher : Lam TPW

List of Research Outputs

 

Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in Fetu - from prenatal ultrasound and MRI diagnosis to postnatal confirmation, Prenatal Diagnosis. 2007, Issue 7, 27: 657 -661.

 

Researcher : Lam WWM

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 153.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation on Three Dimensional Left Ventricular Mycardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., The Impact of Right Ventricular Dilation on Regional Left Ventricular Function in Patients After Tetralogy of Fallot Repair: A Novel Assessment by Speckle Tracking Echocardiography, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function, Heart. 2008, 94: 855-859.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y. and Cheung Y.F., Nowel Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Researcher : Lee R

List of Research Outputs

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13.

 

Researcher : Leong Fung LLY

List of Research Outputs

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13.

 

Researcher : Li G

Project Title:

The Neuroprotective Effect of Coenzyme Q10 in AD mice model

Investigator(s):

Li G, Yang ES, Jack Jr CR

Department:

Medical Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Alzheimer's disease (AD) and ischemic cerebrovascular disease are two main causes of dementia in elderly people. Recent basic and clinical investigations demonstrate that AD and vascular dementia (VaD), traditionally considered two independent neurological disorders, may interact in an additive manner. In clinical studies, the presence of ischemic lesions enhances the cognitive deficits in patients with AD pathology. Mutations in the genes of beta-amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) cause familial AD. In transgenic mice with overexpressed APP, susceptibility to ischemic brain damage caused by middle cerebral artery occlusion (MCAO) is increased. In AD patients, the extent of AD pathology is increased if ischemic stroke coexists. Elderly subjects are more likely to have been demented in life if both AD pathology and ischemic cerebrovascular disease are present at autopsy than if either is pathology is found in isolation. Several studies suggest a possible role of increased oxidative stress and impairment of mitochondrial energy metabolism in the pathogenesis of both AD and stroke. A number of investigators have identified a deficiency in the complex VI, cytochrome c oxidase (COX) of the mitochondrial electron transport chain in AD patients and a reduced activity of complexes I and III in ischemic conditions. Coenzyme Q10 (CoQ10) is an essential biological cofactor produced endogenously in the body and provided in the food chain. As the electron acceptor for mitochondrial complexes I and II, it has an essential role in cellular energy production as an electron and proton carrier. Complex I or II dysfunction are found in neurological disorders such as Parkinson’s disease and Huntington disease. Shults et al. reported a correlation between mitochondrial CoQ10 level and the biological activity of complexes I - IV Parkinson’s disease patients who were administered the highest dose of CoQ10 showed the greatest clinical benefit. Oral CoQ10 supplementation increases brain mitochondrial concentrations and exerts neuroprotective effects. A neuroprotective effect of CoQ10 has been found in various animal models of stroke and this has been attributed to its role as a potent antioxidant and an oxygen derived free radical scavenger. This finding has not been universally replicated, however, as Li and his colleagues found that immediate treatment with CoQ10 via intraperitoneal injection did not prevent neuronal injuries following global and focal ischemia. Mitochondrial abnormalities have been found in human AD patients, and there are a few reports about the therapeutic effect of CoQ10 in AD patients. Results have been mixed however, for example, de Bustos et al. investigated serum levels of CoQ10 in patients with AD and found no relationship with the risk of AD and vascular dementia. CoQ10 has been shown to have a neuroprotective effect in other neurodegenerative diseases, such as Parkinson’s and Huntington’s diseases. In this study, we address the effects of CoQ10 on AD and cerebral ischemia using volume magnetic resonance imaging (MRI) in transgenic animal models. APP/PS1, APP and PS1 transgenic mice with ischemic stroke will be treated with high-dose CoQ10 for 28 days, and then their brain specimens will be examined by MRI to investigate the neuroprotective effects of CoQ10, compared to the non-treated counterparts. Transgenic rather than wild type mice will be employed in order to amplify the destructive effects of stroke in the experimental animals.

 

Project Title:

Effect of imbalance of kinases and protein phosphatases on deposit of B amyloid and Tau Pathology in double transgenic APP/PS1 Mice

Investigator(s):

Li G, Yang X, Yang ES

Department:

Medical Faculty

Source(s) of Funding:

Germany/Hong Kong Joint Research Scheme

Start Date:

01/2007

 

Abstract:

1. To investigate the effect of the overactivation of GSK-3 on deposit of amyloid and tau pathology in APP/PS1 double transgenic mice 2. To investigate the effect of the suppression of the two major proteins - phosphatase 2A and phosphatase 1 on deposit of amyloid and tau pathology in APP/PS1 double transgenic mice This is the first of systematical study on effects of GSK-3/PP2A and PP1 on the main two defining pathological feature-SPs and tau pathology in transgenic mice

 

 

Researcher : Mak HKF

List of Research Outputs

 

Auyeung K.M., Khong P.L., Mak H.K.F. and Chan G.C.F., Unilateral germinoma in the basal ganglia: computed tomography and magnetic resonance imaging findings, Journal of the Hong Kong College of Radiologists . 2008, 11: 24-27.

 

Chan K.S., Mak H.K.F., Ngan S.S.C., Kwong D.L.W. and Khong P.L., Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification, SNM 2008 Annual Meeting, New Orleans, L.A., U.S.A., 14-18 June 2008.

 

Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481.

 

Mak H.K.F., An overview of advance neuro-imaging techniques on cerebral perfusion. , Functional Magnetic Resonance Imaging training workshop, organized by The Hong Kong Polytechnic University, The University of Hong Kong and Hong Kong Association of Rehabilitation medicine. . 2008.

 

Mak H.K.F., Multi-modality imaging of NPC. , T & D Commissioned Training Programme (Radiation Therapist), organized by Hospital Authority. . 2008.

 

Mak H.K.F., Multimodality Imaging in recurrent Head and Neck Tumours. , Head and Neck Course, Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong. . 2008.

 

Mak H.K.F., The role of fMRI in clinical practice- present and future. , Workshop: Primer for fMRI- clinical research and application. Pre-workshop open lecture, Organized by Hong Kong Neuropsychological Association. . 2008.

 

Researcher : Ngan SSC

List of Research Outputs

 

Chan K.S., Mak H.K.F., Ngan S.S.C., Kwong D.L.W. and Khong P.L., Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification, SNM 2008 Annual Meeting, New Orleans, L.A., U.S.A., 14-18 June 2008.

 

Qiu D., Ngan S.S.C., Tan L.H., Chan A.H., Mak H.K. and Khong P.L., Brain connectivity during the processing of nouns and verbs: a dynamic Bayesian network analysis, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:28). 2008.

 

Researcher : Ooi CGC

Project Title:

Nasal T/NK-cell lymphoma: CT and MR imaging features of a new clinico-pathological entity: lethal midline granuloma reclassified

Investigator(s):

Ooi CGC, Liang RHS, Kwong YL, Chim JCS

Department:

Diagnostic Radiology

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/1999

 

Abstract:

To describe the radiological features with respect to computed tomography (CT) and magnetic resonance imaging (MRI) of nasal T/NK cell lymphoma; to devise a local (T) tumour staging system and evaluate any correlation with survival and prognosis.

 

Project Title:

Computed tomography (CT) characterization of irreversible asthma with morphologic functional correlation

Investigator(s):

Ooi CGC, Ip MSM, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To characterize CT features of irreversible or end stage asthma; to develop a scoring system to quantify these changes on CT; to correlate lung function with CT score of lung changes; to evaluate whether small airways disease seen on CT is an association of end-stage asthma; to evaluate the significance of bronchial wall thickening in this condition.

 

Project Title:

Prognostic significance of CT-derived tumour volume in oesophageal cancer

Investigator(s):

Ooi CGC, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To quantify baseline and post chemo-irradiation (post-treatment) tumour volumes (TV) in patients with oesophageal carcinoma using computed tomography (CT); to quantify post-treatment TV based on PET (positron emission tomography)/CT data; to evaluate the relationships between baseline and post-treatment TV, with T-stage, N-stage, overall stage and survival; to evaluate the relationship between SUV (standardised uptake value) uptake in PET and TV; to determine the significance of baseline and post-treatment CT-TV on changes in T and N stage after chemo-irradiation.

 

Project Title:

Clinical utility of radiological assessment of Severe Acute Respiratory Syndrome: a retrospective and prospective study on a cohort of SARS patients

Investigator(s):

Ooi CGC, Tsang KWT, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

VCO SARS Research Fund

Start Date:

07/2003

 

Abstract:

To quantify severity of severe acute respiratory syndrome (SARS) on chest radiograph and to determine its relationship with clinical parameters; to evaluate the predictive value of chest radiographs on oxygen supplementation requirement and treatment response in severe acute respiratory syndrome (SARS); to document serial lung changes on HRCT int he acute and covalescent period; to document and describe irreversible lung changes of HRCT on long term follow-up.

 

Project Title:

HRCT quantification of lung disease in SARS: correlation with clinical parameters and residual disease

Investigator(s):

Ooi CGC, Tsang KWT, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To validate a commercially available quantitative technique in measuring normal lung volume and volume of lung abnormalities on high resolution CT (HRCT) scans; to correlate disease volume measured on HRCT at or near maximal lung disease as defined on chest radiograph in SARS with clinical parameters such as exercise tolerance, and amount of residual disease 6 months after discharge.

 

List of Research Outputs

 

Chan V.N.Y., Chan J., Chim J.C.S., Ooi C.G.C. and Chan T.K., Iron overload in Hb H disease, Fourth International Eijkman Conference, Bali, Indonesia, November 15-18. 2007.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481.

 

Wang S., Tse H.F., Khong P.L. and Ooi C.G.C., High prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients, RSNA 93rd Scientific Assembly and Annual Meeting, Chicago, U.S.A., 25-30 November 2007.

 

Researcher : Pang CBY

Project Title:

Clinical Usefulness of PET/CT in radiotherapy planning in patients with nasopharyngeal carcinoma

Investigator(s):

Pang CBY, Khong PL, Kwong DLW, Kwok SPF

Department:

Diagnostic Radiology

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/2007

 

Abstract:

We aim to prospectively evaluate the clinical utility of PET/CT in the radiotherapy planning for the patients with nasopharyngeal cancer by evaluating the amount of dose modulation and target volume difference using PET/CT for treatment planning comparing to conventional CT treatment planning, and to follow these patients to determine outcome over a 1-year period, and subsequently, 5 year period. We willl also compare the presence and the degree of treatment-related adverse effect between the two groups. The data for the patients who received conventional CT treatment planning will be based on the historical statistics available from the Department of Clinical Oncology. Nasopharyngeal carcinoma (NPC) is an endemic disease in southern China, Hong Kong, Singapore, Taiwan and North Africa [1-3]. To date, the standard curative treatment is radiotherapy. Concurrent and adjuvant chemotherapy will be added to locally advanced disease[4]. Intensity modulated radiotherapy (IMRT) is an advanced form of conformal radiotherapy that conforms a high dose to the planning target volume and keeps a low dose to the normal tissue. In Hong Kong, the radiotherapy planning depends mainly on the CT finding[5]. The clinical target volume (CTV) covers the tumour and the potential sites of local tumour infiltration with 1-cm margin around the gross tumour volume (GTV). The usual coverage of CTV includes the inferior part of sphenoid sinus, both cavernous sinuses, the skull base, the clivus, the posterior part of nasal cavity and antrum, the medial pterygoid muscles and parapharyngeal space, and the prevertebral muscles down to C2 levels. The final planning target volume (PTV) will have an additional 2mm margin to account for possible movement during treatment. PET/CT has been a very valuable tool in diagnosing and staging cancer diseases. There are also encouraging results of using PET/CT for radiotherapy planning of lung cancer. However, less data are available regarding the role of PET/CT fusion in radiotherapy planning with head and neck cancer[6]. IMRT has been proven to improve the quality of life of the patient because of the disease-free structures especially the salivary glands can be spared from the high radiation dose field. We expect that using PET/CT, which provides additional functional data, can help to obtain a more specific therapeutic planning target volume (PTV) and to further improve the quality of life of the patients.To our best knowledge, our study is the first one with the target population of nasopharyngeal cancer alone instead of a group of head and neck tumours. We think this is important because the pattern of nodal spread is different for different types of head and neck tumour and this will have an important influence on the radiotherapy planning[7].

 

List of Research Outputs

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, 2nd Joint Scientific Meeting of the Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, 27-28 October 2007, Hong Kong. 2007.

 

Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, Best Poster Award at 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. 2007.

 

Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and antural killer cell malignancies, 10th International Conference on Malignant Lymphoma, Lugano, Switzerland, 4-7 June 2008.

 

Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21.

 

Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wong M.K.Y., Pang C.B.Y. and Ho J.C.M., Respiratory investigations, In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory Medicine. Hong Kong, 2007, 4-24.

 

Researcher : Qiu D

List of Research Outputs

 

Qiu D., Ngan S.S.C., Tan L.H., Chan A.H., Mak H.K. and Khong P.L., Brain connectivity during the processing of nouns and verbs: a dynamic Bayesian network analysis, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:28). 2008.

 

Qiu D., Tan L.H., Zhou K. and Khong P.L., Diffusion Tensor Imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development, 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance Imaging in Medicine (ISMRM), Toronto, Canada, 3-9 May 2008.

 

Qiu D., Tan L.H., Zhou K. and Khong P.L., Diffusion Tensor Imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development, NeuroImage. Elsevier Inc., 2008, 14: 223-232.

 

Qiu D., Siok W.T., Tan L.H. and Khong P.L., Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wang S., Tam C.N., Wu E.X., Lau H.F., Qiu D., Leung L.H.T. and Khong P.L., Longitudinal diffusion tensor MR imaging study of radiation induced white matter damage in a rat model, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3268). 2008.

 

Researcher : Tai KS

List of Research Outputs

 

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

 

Researcher : Tam CN

List of Research Outputs

 

Wang S., Wu E.X., Tam C.N., Lau H.F., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wang S., Tam C.N., Wu E.X., Lau H.F., Qiu D., Leung L.H.T. and Khong P.L., Longitudinal diffusion tensor MR imaging study of radiation induced white matter damage in a rat model, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3268). 2008.

 

Wang S., Wu E.X., Tam C.N. and Khong P.L., Mild hypoxic-ischemic brain injury in neonatal rats using diffusion tensor MR imaging: a longitudinal study, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada,3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3298). 2008.

 

Researcher : Tso WK

List of Research Outputs

 

Chan F.S., Ng K.K.C., Poon R.T.P., Yuen J.H.F., Tso W.K. and Fan S.T., Duodenalpleural fistula formation after percutaneous radiofrequency ablation for recurrent hepatocellular carcinoma, Asian Journal of Surgery. 2007, 30(4): 278-282.

 

Lam V.W.T., Ng K.K.C., Chok K.S.H., Cheung T.T., Yuen J.H.F., Tung H., Tso W.K., Fan S.T. and Poon R.T.P., Incomplete ablation after radiofrequency ablation of hepatocellular carcinoma: analysis of risk factors and prognostic factors, Annals of Surgical Oncology. 2008, 15(3): 782-790.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma, Journal of Gastrointestinal Surgery. 2008, 12(1): 183-191.

 

Poon R.T.P., Tso W.K., Pang R.W.C., Ng K.K.C., Woo R., Tai K.S. and Fan S.T., A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead, Clinical Gastroenterology and Hepatology. 2007, 5(9): 1100-1108.

 

Researcher : Wang S

List of Research Outputs

 

Wang S., Wu E.X., Tam C.N., Lau H.F., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wang S., Tse H.F., Khong P.L. and Ooi C.G.C., High prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients, RSNA 93rd Scientific Assembly and Annual Meeting, Chicago, U.S.A., 25-30 November 2007.

 

Wang S., Tam C.N., Wu E.X., Lau H.F., Qiu D., Leung L.H.T. and Khong P.L., Longitudinal diffusion tensor MR imaging study of radiation induced white matter damage in a rat model, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada, 3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3268). 2008.

 

Wang S., Wu E.X., Tam C.N. and Khong P.L., Mild hypoxic-ischemic brain injury in neonatal rats using diffusion tensor MR imaging: a longitudinal study, ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada,3-9 May 2008. (Proc Intl Soc Mag Reson Med 2008;16:3298). 2008.

 

Researcher : Wang Y

List of Research Outputs

 

Yang J., Khong P.L., Wang Y., Chu A.C.Y., Ho S.L., Cheung P.T. and Wu E.X., Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury, Magnetic Resonance in Medicine. 2008, 59: 1329.

 

Researcher : Wong HM

List of Research Outputs

 

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Wong H.M., Very late relapse of B cell lymphoma masquerading as blastic transformation of chronic myeloid leukemia, Leuk Lymphoma. 2007, 48(7): 1414-1416.

 

Researcher : Wong LLS

List of Research Outputs

 

Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Interobserver and intra-observer errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee arthroplasty, The Journal of Arthroplasty. 2007, 22(8): 1150-1161.

 

Researcher : Wu EX

Project Title:

Magnetic resonance imaging for biomedical research

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

02/2004

 

Abstract:

To develop and acquire the basic and necessary software and hardware required for the MRI research at HKU.

 

Project Title:

Manganese-enhanced Magnetic Resonance Imaging of Rodent Brain Function and Pathology

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Manganese ions (Mn++) have been recently discovered as a Ca++ analog in neuronal transport that tracks various active neuronal pathways and cortical projections. The primary objective of this project is to explore and develop in vivo Mn-enhanced MRI (MEMRI) technology that is suitable for interrogation of rodent brain functions in normal and pathological states. The specific aims are to (1) establish an optimal high-resolution MEMRI protocol to detect neural activity in various regions of normal rodent brain; (2) define and characterize altered patterns of MEMRI enhancement associated with neonatal hypoxia ischemia in mouse model and glaucoma in rat model.

 

Project Title:

MRI of gas-filled microbubbles for microbubble-based therapeutic applications

Investigator(s):

Wu EX, Xu B, Khong PL

Department:

Engineering Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2006

 

Abstract:

To characterize MRI sensitivity in detecting gas-filled microbubbles; to evaluate the ability of MRI to monitor microbubble cavitation procedure in real time; to explore and evaluate a new gas-filled microbubble design that has enhanced MRI detectability.

 

Project Title:

Magnetic Resonance Measurement of Heart and Liver Iron

Investigator(s):

Wu EX

Department:

Electrical & Electronic Engg

Source(s) of Funding:

The National Institute of Diabetes and Digestive and Kidney Diseases

Start Date:

11/2006

 

Abstract:

1. Implementation and optimization of projection-reconstruction, gradient- and spin-echo imaging sequences to map T2 and T2* in test phantoms. The work initially will be performed at 7 Tesla for testing and then implemented for clinical imaging at 3 Tesla. This component of the research work will also include development of necessary software toolkits for image data analysis. 2.Optimization of clinical protocols at 3 Tesla for T2 and T2* measurements using projection-reconstruction, gradient- and spin-echo sequences in the anterior pituitary, pancreas and gonads. 3. Estimates of iron deposition in the anterior pituitary, pancreas and gonads using the optimized MRI protocols will be compared with the results of clinical evaluation of endocrine function in a group of thalassaemia patients with a wide range of body iron burdens.

 

Project Title:

Cell labeling for In Vivo MRI Monitoring after Transplantation in Cell Based Therapies

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their therapeutic potential. High-field magnetic resonance imaging (MRI) is potentially capable of tracking transplanted stem cells, and characterizing resulting anatomical, physiological and functional recovery in vivo, intact, and with high spatial resolution. We propose to develop such cellular imaging methodology on a 7 Tesla MRI scanner by (i) designing various techniques to label cells in vitro and quantitatively monitoring their in vivo distribution and activity after transplantation in stem cell therapy in rat stroke model; (ii) characterizing the therapeutic outcome in terms of anatomical structures and physiological functions using various MRI methods.

 

 

Researcher : Yuen JHF

List of Research Outputs

 

Chan F.S., Ng K.K.C., Poon R.T.P., Yuen J.H.F., Tso W.K. and Fan S.T., Duodenalpleural fistula formation after percutaneous radiofrequency ablation for recurrent hepatocellular carcinoma, Asian Journal of Surgery. 2007, 30(4): 278-282.

 

Khan M.R., Poon R.T.P., Ng K.K.C., Chan A.C., Yuen J.H.F., Tung H., Tsang J. and Fan S.T., Comparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinoma, Archives of Surgery. 2007, 142(12): 1136-1143.

 

Lam V.W.T., Ng K.K.C., Chok K.S.H., Cheung T.T., Yuen J.H.F., Tung H., Tso W.K., Fan S.T. and Poon R.T.P., Incomplete ablation after radiofrequency ablation of hepatocellular carcinoma: analysis of risk factors and prognostic factors, Annals of Surgical Oncology. 2008, 15(3): 782-790.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma, Journal of Gastrointestinal Surgery. 2008, 12(1): 183-191.

 

Researcher : Zhang J

List of Research Outputs

 

Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007.



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