DEPT OF CLINICAL ONCOLOGY
| Researcher : Au GKH |
| List of Research Outputs |
| Choi C.K., Chan T.T., Tung S.Y., Lui L., Siu S., Au G.K.H., Ho J.W.C. and Law W.L., Efficacy of combination chemotherapy with irinotecan (CPT-11) plus capecitabine in patients with metastatic or advanced colorectal carcinoma - a dual-centre phase II study: the MAC-6, Clinical Oncology (Royal College of Radiologists (Great Britain)). 2008, 20(2): 168-175. |
| Chua D.T.T., Wei W.I., Sham J.S.T. and Au G.K.H., Capecitabine monotherapy for recurrent and metastatic nasopharyngeal cancer., Japanese Journal of Clinical Oncology. Japan, 2008, 38: 244-9. |
| Chua D.T.T., Wei W.I., Sham J.S.T., Hung K.N. and Au G.K.H., Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physics. 2007, 69: 469-74. |
| Researcher : Chan TT |
| List of Research Outputs |
| Choi C.K., Chan T.T., Tung S.Y., Lui L., Siu S., Au G.K.H., Ho J.W.C. and Law W.L., Efficacy of combination chemotherapy with irinotecan (CPT-11) plus capecitabine in patients with metastatic or advanced colorectal carcinoma - a dual-centre phase II study: the MAC-6, Clinical Oncology (Royal College of Radiologists (Great Britain)). 2008, 20(2): 168-175. |
| Researcher : Chen L |
| List of Research Outputs |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Researcher : Chen M |
| List of Research Outputs |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Researcher : Chow HY |
| List of Research Outputs |
| Fu L., Qin Y.R., Xie D., Chow H.Y., Ngai S.M., Kwong D.L.W., Li Y. and Guan X.Y., Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches., Cancer. 2007, 110: 2672-2681. |
| Researcher : Chua DTT |
| List of Research Outputs |
| Chua D.T.T., Advances in Radiotherapy of Nasopharyngeal Carcinoma, Seventeenth Singapore Radiological Society Annual Scientific Meeting. 2008. |
| Chua D.T.T., Wei W.I., Sham J.S.T. and Au G.K.H., Capecitabine monotherapy for recurrent and metastatic nasopharyngeal cancer., Japanese Journal of Clinical Oncology. Japan, 2008, 38: 244-9. |
| Chua D.T.T., Chemotherapy for Nasopharyngeal Cancers, Twelfth Uludang Oncology Symposium. 2007. |
| Chua D.T.T., Chemotherapy for Pharyngeal Cancers, Twelfth Uludang Oncology Symposium. 2007. |
| Chua D.T.T., Tian Y. and Wei W.I., Late oral complications following radiotheraphy for head and neck cancers, Expert Rev Anticancer Therapy. 2007, 7: 1215-24. |
| Chua D.T.T., Molecular Targeted Therapy for Head and Neck Cancer, Annual Scientific Meeting of Hong Kong Medical Association. 2007. |
| Chua D.T.T., Nasopharynx, Principle and Practice of Radiation Oncology. Lippincott William and Wilkins, 2007. |
| Chua D.T.T., New Perspectives in the Molecular Treatment of HER2+ Breast Cancer., Macau Oncology Association Symposium.. 2007. |
| Chua D.T.T., Prognostic Value and Treatment Implication of Epidermal Growth Factor Receptor and Annexin I Protein Expression in Nasopharyngeal Carcinoma., Nasopharyngeal Carcinoma East-West Symposium.. 2007. |
| Chua D.T.T., Recent Advances in Molecular Targets and Targeted Therapy in Pharyngeal Tumors, Twelfth Uludang Oncology Symposium.. 2007. |
| Chua D.T.T., Wei W.I., Sham J.S.T., Hung K.N. and Au G.K.H., Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physics. 2007, 69: 469-74. |
| Chua D.T.T., Translational Research in Nasopharyngeal Carcinoma, Second Singapore Society of Oncology Joint Review Course 2008. 2008. |
| Lee D.C.W., Chua D.T.T., Wei W.I., Sham J.S.T. and Lau A.S.Y., Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from Nasopharyngeal carcinoma, Biomedicine & Pharmacotherapy. 2007, 61: 520-526. |
| Lo P.H.Y., Xie D., Chan K.C., Xu F.P., Kuzmin I., Lerman M.I., Law S.Y.K., Chua D.T.T., Sham J.S.T. and Lung M.L., Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage, Cancer Letters. 2007, 257(2): 199-205. |
| Lung H.L., Lo P.H., Xie D., Apte S.S., Cheung A.K., Cheng Y., Chua D.T.T., Zeng Y.X., Tsao G.S.W., Standbridge E.J. and Lung M.L., Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association iwthlymph node metastases in nasopharyngeal carcinoma, International Journal of Cancer. 2008, 123: 401-408. |
| Wu S.X., Chua D.T.T., Sham J.S.T., Deng M.L., Bao Y., Wang H.Y., Gao Y.H., Li F.Y. and Xeng Z.F., Outcome of fractionated stereotactic radiotherapy for 90 patients with locally persistent and recurrent nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2007, 69: 761-769. |
| Researcher : Fu L |
| List of Research Outputs |
| Fu L., Qin Y.R., Xie D., Hu L., Kwong D.L.W., Srivastava G., Tsao G.S.W. and Guan X.Y., Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma, Cancer Res. 2007, 67(22): 10720-6. |
| Fu L., Qin Y.R., Xie D., Chow H.Y., Ngai S.M., Kwong D.L.W., Li Y. and Guan X.Y., Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches., Cancer. 2007, 110: 2672-2681. |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Researcher : Fung JMW |
| List of Research Outputs |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Researcher : Guan XY |
| Project Title: | Isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2001 |
| Abstract: |
| To study isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis. |
| Project Title: | Basic research for the mechanisms of development and progression of malignant tumors |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2002 |
| Abstract: |
| To identify recurrent genomic alterations in 30 primary adenocarcinomas of lung and carcinomas using CGH technology; to establish gene expression profiles for lung cancer using cDNA microarray technique; to establish 10 pairs of xenografts of primary and their matched metastatic lung cancer by transplanting tumor cells into nude mice; to study the differences between primary and metastasis lung cancer with mentioned xenografts. |
| Project Title: | Identification of the mechanism of hepatitis B virus (HBV) integration in the development of hepatocellular carcinoma (HCC) |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2003 |
| Abstract: |
| Although the integration of HBV has been associated with the development of HCC, the molecular mehanism remains unclear. It is believed that HBV and host factors (e.g. inflammatory/genetic factors) may contribute together to the process of HCC development. Although the association of HBV and HCC development has been widely studied, only a limited number of integrated HBV have been completely analyzed. Therefore, additional studies with more cases are needed to understand roles of HBV integrants involved in the HCC development. In order to obtain additional insight into the correlation of HBV integration and HCC development, integrated HBV in 10-20 HCC cases will be isolated and characterized by sequencing analysis. findings in this project may greatly facilitate the early diagnosis and prevention of HCC. |
| Project Title: | Characterization of oncogenic role of SEI-1 in the development of ovarian cancer |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2004 |
| Abstract: |
| To study the tumorigenisity of SEI-1 using both in vitro and in vivo approaches; to define the clinical and pathological significance of the amplification of SEI-1 in ovarian cancer. |
| Project Title: | Characterization of roles of a novel oncogene ALC-1 in the development of hepatocellular carcinoma |
| Investigator(s): | Guan XY, Huang J |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 10/2004 |
| Abstract: |
| To confirm the tumorigenic role of ALC-1; to investigate the biochemical properties of ALC-1; to study the functions of ALC-1 in vivo by the generation and characterization of transgenic mice overexpressing the ALC-1 gene; to define the clinical and pathological significance of the amplification of ALC-1 in HCC using high-throughput tissue microarray. |
| Project Title: | Oncogeneic role of hepatitis B Virus (HBV) X gene in the development of hepatocellular carcinoma |
| Investigator(s): | Guan XY, Sham JST |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2005 |
| Abstract: |
| To investigate three aspect: 1) characterization of biological role of full-length X and truncated HBx in cell proliferation and apoptosis; 2) identification and characterization of genes regulated by full-length X and truncated HBx using cDNA microarray; 3) construction of an HCC tissue microarray (TMA) with HBV-positive and HBV-negative HCC cases, and application of the TMA in the characterization of candidate genes correlated with HCC carcinogenesis. |
| Project Title: | Characterization of Tumor Suppressing Role of Tyrosine Aminotransferase in HCC |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Abstract: |
| Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, especially in Asia including China, and its prognosis has been very poor. It is believed that the pathogenesis of HCC is a long-term process that involves multiple genetic alterations. Deletion of 16q is one of the most frequent chromosomal alterations in primary HCC, as observed in studies using loss of heterozygosity (LOH) and comparative genomic hybridization (CGH). In our previous CGH study, the loss of 16q was observed at a strikingly high rate of 70% in 50 primary HCC cases and this deletion may be an early event in the pathogenesis of HCC. These results strongly suggest that 16q may harbor one or more tumor suppressor genes. Recently, a candidate tumor suppressor gene, Tyrosine aminotransferase (TAT), at 16q22.1 was isolated by cDNA subtraction. Our preliminary work showed that absence and marked reduction expression of TAT was frequently observed in HCC. In addition, homo-deletion of TAT gene was detected in 2/24 HCC cases. TAT encodes the enzyme tyrosine aminotransferase which controls the rate-limiting step for tyrosine catabolism. Many studies have demonstrated that defects in tyrosine catabolism are associated with liver cirrhosis and HCC development. These results suggest that TAT is a candidate tumor suppressor gene and may play an important role in the pathogenesis of HCC. The key objective of this proposal is to investigate the tumor suppressing function of TAT and its role in HCC development. Objectives 1) To investigation of the loss of DNA copy-number in TAT region at 16q22.1 in primary HCC cases. Deletion of DNA copy-number will be studied by real-time PCR. 2) To study TAT expression level in primary HCC cases. TAT expression level in primary HCCs will be compared with their matched non-tumor liver tissues by Northern blot analysis. 3) Mutation analysis of TAT gene and characterization of methylation status at promoter region of TAT gene. |
| Project Title: | Establishment of a High-Throughput Prenatal Diagnostic System for the Detection of Genetic Disorders |
| Investigator(s): | Guan XY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 10/2006 |
| Abstract: |
| Porpose of the proposed project: Around 3-5% new born babies suffer from genetic disorders in the world and de novo chromosomal change (both numeric and structural changes) is the leading cause of genetic disorders such as Down syndrome. In addition, chromosome abnormality accounted for up to 69.4% spontaneous abortions (Ohno et al., 1991). Therefore, detection of chromosomal changes is one of the key issues addressed in prenatal diagnosis. Currently, several approaches including karyotyping, fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) are frequently used to detect de novo chromosomal alterations in clinical laboratory. Karyotyping is the most frequently used method in prenatal diagnosis which can detect almost all numeric and most structural chromosomal changes. Our laboratory has been working on karyotyping analysis in solid tumors for long time. Karyotyping analysis can provide a whole picture of chromosome status. However, the resolution of karyotyping is very low which can not effectively detect microdeletion less than 10 mega-base pairs. In addition, karyotyping analysis can be only used to analyze mitotic active cells and short-term cell culture is needed. FISH technology was developed in the late 1980s (Pinkel et al., 1986) and it is widely used to detect microdeletions associated with specific diseases, to characterize chromosome rearrangements and marker chromosomes, and to identify aneuploidies in prenatal diagnosis. Previously, we have developed whole chromosome painting probes (Guan et al., 1994), chromosome arm painting probes (Guan et al., 1996) and terminal band-specific painting probes for prenatal diagnosis (Hu et al., 2004). One advantage of FISH is that it can detect chromosomal changes in both metaphase chromosomes and interphase nuclei. For each FISH reaction, 2-3 probes are usually used. Therefore, it is difficult to select probes to study unknown chromosome rearrangements. In addition, the expensiveness and limited types of FISH probes also confine the application of FISH technology. CGH was developed to analyze the entire genome for regional variations of DNA copy number in a single experiment (Kallioniemi et al., 1992). CGH do not need the preparation of metaphase of each sample and it has been widely used in cancer research to find the recurrent genetic alterations in a given cancer (Guan et al., 2000). CGH has also been applied to detect chromosome abnormalities in aborted samples (Tan YQ, et al., 2004). One limitation of CGH is that it can only detect DNA copy number change, but not balanced translocation (one of the most frequent de novo chromosomal changes). Another limitation is the resolution of CGH. Using standard procedures, the detectable size of DNA copy-number change (gain or loss) is about 10Mb. Furthermore, all above three techniques are manual manipulated and can not be automated. Thus, the need for a method for automated screening of chromosomal abnormalities is of utmost importance. Recently, we have used inter-Alu PCR products to generate an Array-CGH platform for cancer research. The array chip contains 600 DNA samples derived from BAC clones of chromosomes 3, 5p, 13, 16q, and 19. This Array-CGH has been applied to study DNA copy-number change in 20 primary lung cancer cases and 50 primary hepatocellular carcinoma (HCC) cases. The results showed that this novel Array-CGH technology is very reliable and several frequently deleted and amplified regions on these chromosomes have been identified. In this proposal, we intend to combine our unique expertise (inter-Alu PCR) to develop a high-throughput Array-CGH chip for the detection of numeric and structural chromosome changes in prenatal diagnosis. Our Array-CGH chip will be composed of inter-Alu PCR amplified DNA from 400 bacterial artificial chromosome (BAC) clones. These BAC clones cover all sub-telomere regions and most frequently deleted regions in prenatal disorders. Objectives: 1. Generation of an Array-CGH chip using DNA products amplified by inter-Alu PCR from 400 BAC clones. 2. Validation of this Array-CGH chip by cell lines and clinical samples. Reference: Guan X-Y, Meltzer PS, Trent JM. (1994) Rapid construction of whole chromosome painting probes by chromosome microdissection. Genomics 22:101-107. Guan X-Y, Zhang HE, Bitter M, Jiang Y, Meltzer PS, Trent JM. (1996) Chromosome arm painting probes. Nature Genet 12:10-11. Guan X-Y, Fang Y, Sham JST, Kwong DLW, Zhang Y, Liang Q, Li H, Zhou H, Trent JM. (2000) Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 29:110-116. Hu L, Sham JST, J, Tjia WM, Tan YQ, Lu GX, Guan X-Y. (2004) Generation of a complete set of human telomeric-band painting probes by chromosome microdissection. Genomics 83:298-302. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821. Ohno M, Maeda T, Matsunobu A. (1991) A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi. Obstet Gynecol 77:394-398. Pinkel D, Straume T, Gray JW. (1986) Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83:2934-2938. Tan YQ, Hu L, Lin G, Sham JS, Gong F, Guan XY, Lu G. (2004) Genetic changes in human fetuses from spontaneous abortion after in vitro fertilization detected by comparative genomic hybridization. Biol Reprod 70:495-499. |
| List of Research Outputs |
| Cheung A., Deng W., Tsao G.S.W. and Guan X.Y., Centromeric instability in human cells undergoing immortalization., Proceedings of American Association for Cancer Research Annual Meeting; 2008 Apr 12-16; San Diego, CA. Abstract nr 4318. 2008, 4318. |
| Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Tang W.K., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of Chinese origin, Cancer Genetics and Cytogenetics. 2007, 178(1): 17-25. |
| Deng W., Tsao G.S.W., Guan X.Y. and Cheung A., Microtubule breakage is not a major mechanism for resolving end-to-end chromosome fusions generated by telomere dysfunction during the early process of immortalization, Chromosoma. 2007, 116: 557-568. |
| Fu L., Qin Y.R., Xie D., Hu L., Kwong D.L.W., Srivastava G., Tsao G.S.W. and Guan X.Y., Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma, Cancer Res. 2007, 67(22): 10720-6. |
| Fu L., Qin Y.R., Xie D., Chow H.Y., Ngai S.M., Kwong D.L.W., Li Y. and Guan X.Y., Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches., Cancer. 2007, 110: 2672-2681. |
| Hu L., Sham J.S.T., Xie D., Wen J.M., Wang W.S., Wang Y. and Guan X.Y., Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma., Cancer Letters. 2007, 252: 36-42. |
| Lee K.W., Poon R.T.P., Man K., Guan X.Y., Ma S.K.Y., Liu X., Myers J.N. and Yuen P.W., Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma, Cancer Letters. 2007, 254(2): 308-315. |
| Lee K.W., Poon R.T.P., Wo Y.H., Ma S.K.Y., Guan X.Y., Myers J.N., Altevogt P. and Yuen P.W., Lupeol suppresses cisplatin induced NFkB activation in HNSCC cells and inhibits local invasion and nodal metastasis in orthotopic nude mouse model of tongue squamous cell carcinoma, Cancer Research. 2007, 67(18): 8800-8809. |
| Li Y., Loo T.Y., Guan X.Y. and Chen J., anticancer effect if Dioscin in breast and esopageal cancer cells, the 6th Biennial meeting of Asian Breast cancer society . 2007. |
| Liu M.Z., Xie D., Mai S.J., Tong Z.T., Shao J.Y., Fu Y.S., Xia W.J., Kung H.F., Guan X.Y. and Zeng Y.X., Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage., Am J Clin Pathology. 2008, 129: 728-734. |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Ma S.K.Y., Lee K.W., Zheng B., Chan K.W. and Guan X.Y., CD133+ HCC cancer stem cells promote chemoresistance by preferential expression of the Akt/PKB survival pathway, Oncogene. 2008, 27: 1749-1758. |
| Ma S.K.Y., Guan X.Y., Lee K.W. and Chan K.W., Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma, Hum Pathol. 2007, 38(8): 1201-6. |
| Ma S.K.Y., Hu L., Huang X.H., Cao L.Q., Chan K.W., Wang Q. and Guan X.Y., Establishment and characterization of a human cholangiocarcinoma cell line., Oncology Report. 2007, 18: 1195-1200. |
| Ma S.K.Y. and Guan X.Y., Identification and characterization of liver cancer stem cells, Hong Kong - Shanghai International Liver Congress. 2008. |
| Qin Y., Wang L.D., Fan Z.M., Kwong D.L.W. and Guan X.Y., Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China. , World J Gastroenterology. 2008, 14: 1828-1835. |
| Wang J., Tai L.S., Tzang C.H., Fong W.F., Guan X.Y. and Yang M., 1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells., Oncology Report. 2008, 19: 1155-1164. |
| Xie D., Ma N., Pan Z.Z., Wu H.X., Liu Y.D., Wu G.Q., Kung H.F. and Guan X.Y., Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. , Human Pathology. 2008, 39: 80-86. |
| Yi X., Luk J.M.C., Lee P.Y., Peng J., Leng X., Guan X.Y., Lau G., Beretta L. and Fan S.T., Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence, Molecular and Cellular Proteomics. 2008, 7(2): 315-325 (corresponding author). |
| Zhou J., Huang J., Poon K.M., Chen D., Chan C.S., Ng F., Guan X.Y., Watt R.M., Lu L., Yuen K.Y. and Zheng B., A mechanism underlying susceptibility to HBV infection: HBV down-regulate transferase-1 type I interferon receptor 1 via suppressing poly(ADP-ribose), 2007 International Meeting: The Molecular Biology of Hepatitis B Viruses.. 2007. |
| Researcher : Hu L |
| List of Research Outputs |
| Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Tang W.K., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of Chinese origin, Cancer Genetics and Cytogenetics. 2007, 178(1): 17-25. |
| Fu L., Qin Y.R., Xie D., Hu L., Kwong D.L.W., Srivastava G., Tsao G.S.W. and Guan X.Y., Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma, Cancer Res. 2007, 67(22): 10720-6. |
| Hu L., Sham J.S.T., Xie D., Wen J.M., Wang W.S., Wang Y. and Guan X.Y., Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma., Cancer Letters. 2007, 252: 36-42. |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Ma S.K.Y., Hu L., Huang X.H., Cao L.Q., Chan K.W., Wang Q. and Guan X.Y., Establishment and characterization of a human cholangiocarcinoma cell line., Oncology Report. 2007, 18: 1195-1200. |
| Researcher : Kwong DLW |
| List of Research Outputs |
| Chan K.S., Mak H.K.F., Ngan S.S.C., Kwong D.L.W. and Khong P.L., Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification, SNM 2008 Annual Meeting, New Orleans, L.A., U.S.A., 14-18 June 2008. |
| Choy E.Y.W., Siu K.L., Kwong D.L.W., Tsao G.S.W. and Jin D., Epstein-Barr virus-encoded microRNA targets PUMA to promote tumor cell survival , 2008 Miami Winter Symposium, A Nature Conference on Regulatory RNA in Biology and Human Health. Miami Beach, Florida, USA, 2008. |
| Choy E.Y.W., Siu K.L., Kwong D.L.W., Tsao G.S.W. and Jin D., First place in poster competition, 2008 Miami Winter Symposium, A Nature Conference on Regulatory RNA in Biology and Human Health. Miami Beach, Florida, USA, 2008. |
| Fu L., Qin Y.R., Xie D., Hu L., Kwong D.L.W., Srivastava G., Tsao G.S.W. and Guan X.Y., Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma, Cancer Res. 2007, 67(22): 10720-6. |
| Fu L., Qin Y.R., Xie D., Chow H.Y., Ngai S.M., Kwong D.L.W., Li Y. and Guan X.Y., Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches., Cancer. 2007, 110: 2672-2681. |
| Kwong D.L.W., Cyclooxygenase expression in nasopharyngeal carcinoma, American Society for Therapeutic Radiology and Oncology 49th Annual Meeting, Los Angeles, California, USA. 2007. |
| Kwong D.L.W., HK: Role of image fusion in NPC, T&D Commissioned Training (Radiation Therapist) 2008/09. QEH, 2008. |
| Kwong D.L.W., Long-term results of concurrent and adjuvant chemotherapy for advanced nasopharyngeal carcinoma, The American Society of Clinical Oncology 2008 Annual Meeting, Chicago, USA. 2008. |
| Kwong D.L.W., Recurrent Head and Neck Tumors: 1. Conventional radiotherapy - when and why? 2. Chemotherapy and targeted therapy, Head & Neck Course 2008. 2008. |
| Nicholls J.M., Chan M.C., Chan W.Y., Wong H.K., Cheung C.Y., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L., Tsao S.W., Guan Y. and Peiris J.S.M., Jropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nat Med. 2007, 13: 147-9. |
| Qin Y., Wang L.D., Fan Z.M., Kwong D.L.W. and Guan X.Y., Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China. , World J Gastroenterology. 2008, 14: 1828-1835. |
| Qiu D., Kwong D.L.W., Chan G.C., Leung L.H. and Khong P.L., Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity?, Int J Radiat Oncol Biol Phys. 2007, 69(3): 846-51. |
| Yuan X.J., Chan G.C.F., Chan S.K., Shek T.W.H., Kwong D.L.W., Wei W.I., Ha S.Y. and Chiang A.K.S., Treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children, Hong Kong Medical Journal. 2008, 14(2): 116-123. |
| Researcher : Kwong PWK |
| List of Research Outputs |
| Chan K.K.L., Ip P.P.C., Kwong P.W.K., Tam K.F. and Ngan H.Y.S., A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix (p 559-563) , In: John J. Kavanagh and Uziel Beller, International Journal of Gynecological Cancer. Wiley interscience, 2008, 18: 559-563. |
| Researcher : Lee VHF |
| List of Research Outputs |
| Lee V.H.F., Oncological emergencies, In: Dr. Lee Ho Fun Victor, Nursing Department, Queen Mary Hospital.. 2008. |
| Researcher : Ma N |
| List of Research Outputs |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Xie D., Ma N., Pan Z.Z., Wu H.X., Liu Y.D., Wu G.Q., Kung H.F. and Guan X.Y., Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. , Human Pathology. 2008, 39: 80-86. |
| Researcher : Qin Y |
| List of Research Outputs |
| Qin Y., Wang L.D., Fan Z.M., Kwong D.L.W. and Guan X.Y., Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China. , World J Gastroenterology. 2008, 14: 1828-1835. |
| Researcher : Sham JST |
| List of Research Outputs |
| Chua D.T.T., Wei W.I., Sham J.S.T. and Au G.K.H., Capecitabine monotherapy for recurrent and metastatic nasopharyngeal cancer., Japanese Journal of Clinical Oncology. Japan, 2008, 38: 244-9. |
| Chua D.T.T., Wei W.I., Sham J.S.T., Hung K.N. and Au G.K.H., Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physics. 2007, 69: 469-74. |
| Ho T.H., Chan C.L.W., Lee P.W.H., Sham J.S.T. and Chow L.W.C., Active Treatment with Professionals Yields Promising and Sustained Advantages for Chinese Breast Cancer Patients: A Randomized Controlled Trial of Psychosocial Interventions in Hong Kong, Psycho-Oncology. 2007, 16(9): S13. |
| Hu L., Sham J.S.T., Xie D., Wen J.M., Wang W.S., Wang Y. and Guan X.Y., Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma., Cancer Letters. 2007, 252: 36-42. |
| Lee D.C.W., Chua D.T.T., Wei W.I., Sham J.S.T. and Lau A.S.Y., Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from Nasopharyngeal carcinoma, Biomedicine & Pharmacotherapy. 2007, 61: 520-526. |
| Lo P.H.Y., Xie D., Chan K.C., Xu F.P., Kuzmin I., Lerman M.I., Law S.Y.K., Chua D.T.T., Sham J.S.T. and Lung M.L., Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage, Cancer Letters. 2007, 257(2): 199-205. |
| Wu S.X., Chua D.T.T., Sham J.S.T., Deng M.L., Bao Y., Wang H.Y., Gao Y.H., Li F.Y. and Xeng Z.F., Outcome of fractionated stereotactic radiotherapy for 90 patients with locally persistent and recurrent nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2007, 69: 761-769. |
| Researcher : Tai LS |
| List of Research Outputs |
| Wang J., Tai L.S., Tzang C.H., Fong W.F., Guan X.Y. and Yang M., 1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells., Oncology Report. 2008, 19: 1155-1164. |
| Researcher : Tang D |
| List of Research Outputs |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Researcher : Xie D |
| List of Research Outputs |
| Fu L., Qin Y.R., Xie D., Chow H.Y., Ngai S.M., Kwong D.L.W., Li Y. and Guan X.Y., Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches., Cancer. 2007, 110: 2672-2681. |
| Hu L., Sham J.S.T., Xie D., Wen J.M., Wang W.S., Wang Y. and Guan X.Y., Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma., Cancer Letters. 2007, 252: 36-42. |
| Liu M.Z., Xie D., Mai S.J., Tong Z.T., Shao J.Y., Fu Y.S., Xia W.J., Kung H.F., Guan X.Y. and Zeng Y.X., Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage., Am J Clin Pathology. 2008, 129: 728-734. |
| Ma N., Hu L., Fung J.M.W., Xie D., Zheng B., Chen L., Tang D., Fu L., Wu Z., Chen M., Fang Y. and Guan X.Y., Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma., Hepatology. 2008, 47: 503-510. |
| Xie D., Ma N., Pan Z.Z., Wu H.X., Liu Y.D., Wu G.Q., Kung H.F. and Guan X.Y., Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. , Human Pathology. 2008, 39: 80-86. |