DEPT OF PAEDIATRICS & ADOLESCENT MED

Researcher : Bhatia I

List of Research Outputs

 

Zhou Y., Bhatia I., Cai Z., He Q., Cheung P.T. and Chiu J., Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins, J Proteome Research. 2008, 7: 2507.

 

Researcher : Chan GCF

Project Title:

Treatment protocol for childhood medulloblastoma in Hong Kong

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/2001

 

Abstract:

To study the treatment outcome of this most common form of childhood brain tumour in Hong Kong.

 

Project Title:

Review of local experience in the management of childhood myelodysplastic syndrome

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/2001

 

Abstract:

To study the local incidence and outcome of this rare type of childhood maliquancy.

 

Project Title:

Survey on the prevalence on use of alternative medical treatment in paediatric patients

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

09/2001

 

Abstract:

To study the prevalence, pattern of usage and the underlying predisposing factors on the use of alternative medicine in children.

 

Project Title:

Direct generation and functional characterization of human dendritic cells derived from bone marrow cells of leukemic origins

Investigator(s):

Chan GCF, Chiu CSW, Ma ESK, Huang F

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

07/2002

 

Abstract:

To determine the implication of dentritic cells generated from leukaemic cellls on the host immune system.

 

Project Title:

Health-related quality of life measures for Hong Kong Chinese children with cancer

Investigator(s):

Chan GCF, Fielding R, Lam WWT, Ng MW

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Health and Health Services Research Fund - Full Grants

Start Date:

01/2005

 

Abstract:

Children under age 5 constiture >50% of new paediatric cancer cases. HRQoL impacts on these children are currently arbitrarily assessed (in HK) or use proxy measures which lack reliability and are subject to significant bias. A tool measuring changes in HRQoL would be of great value to paediatric oncologists to better and more consistently address HRQoL impacts, facilitating optimized paediatric cancer care. Such a tool is currently lacking and is badly needed

 

Project Title:

Influence of MYCN amplification on the response of neuroblastoma to arsenic trioxide (As2O3) in-vitro and in-vivo

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2005

 

Abstract:

To find out whether As2O3 can induce apoption on both MYCN amplified and non-amplified neuroblastoma cells; to identify the in reinstance pattern to As2O3 and replace whether resistant clones may generate faster from neuroblastoma cells with MYCN amplification; to established a dose limiting toxicity profile of As2O3 in vivo and study the toxicity, bio-availability and bio-distribution of arsenical compounds.

 

Project Title:

Comparing the effect of different purified beta-glucans on the maturation and function of human dendritic cells (DC) in vitro

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

We will investigate and compare the effect of different beta-glucans on human immune cells in particularly on the dendritic cells (DC) in vitro.

 

Project Title:

Exploring the mechanisms of microtubules toxins on human mesenchymal stem cells

Investigator(s):

Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

We previously identified that human mesenchymal stem cells (MSC) are resistant to most chemotherapy tested but are particularly sensitive to microtubule toxins such as vincristine and paclitaxel (Li J, Chan GCF. 2004). We would like to explore this peculiar sensitivity pattern by looking at some of the possible mechanisms involved in this project. This can potentially help us to develop protective measure for the MSC during chemotherapy.

 

List of Research Outputs

 

Auyeung K.M., Khong P.L., Mak H.K.F. and Chan G.C.F., Unilateral germinoma in the basal ganglia: computed tomography and magnetic resonance imaging findings, Journal of the Hong Kong College of Radiologists . 2008, 11: 24-27.

 

Chan B.P., Hui T.Y., Chan G.C.F., Chan D. and Cheung K.M.C., Collagen-mesenchymal stem cell microspheres for regenerative medicine., World Forum for Spine Research, Kyoto, Japan (Best oral pesentation award), Jan 23-26. Kyoto, Japan, AOSpine International, 2008, 84.

 

Chan B.P., Hui T.Y., Chan G.C.F., Chan D. and Cheung K.M.C., Collagen-mesenchymal stem cell microspheres for regenerative medicine, Best Oral Presentation Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008. 2008.

 

Chan B.P., Hui T.Y., Yeung C.W. and Chan G.C.F., Self-Assembled Collagen-Human Mesenchymal Stem Cell (hMSCs) Microspheres – Novel Bio-devices for Cell Delivery, The 34th Annual Meeting and Exposition of the Controlled Release Society, 7-11 Jul 2007. Long Beach, California, USA. 2007, p566.

 

Chan B.P., Hui T.Y., Yeung C.W., Li J., Mo F.Y. and Chan G.C.F., Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine, Biomaterials. 2007, 28: 4652-4666.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., Epidemiology & treatment outcome of childhood ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group. , Neurooncol 2008. 2008, 10(3):413.

 

Chan G.C.F., Applying experimental treatments to metastatic neuroblastoma: the Hong Kong experience. , 14th Hong Kong International Cancer Congress & 4th Annual Meeting of Centre for Cancer Research. Nov 13-16, 2007.. 2007.

 

Chan G.C.F., As Chairperson for the State-of-the-Art Lecture, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Chan G.C.F., Shing M.M.K., Luk C.W., Li R.C.H., Ling S.C., Li C.K. and Ha S.Y., Characteristis & Outcome of Early Stage Neuroblastoma Treated with Surgery Alone or Low Intensity Chemotherapy, Advances in Neuroblastoma Research 2008, Chiba, Japan, 21-24 May 2008. 176.

 

Chan G.C.F., Common Paediatric Haematological Disorders. , "Haematological Diseases Lecture Series”, Hong Kong Chinese Medical Association. Jan 12, 2008. . 2008.

 

Chan G.C.F., Common bleeding disorders in children, 兒童出血性疾病的基礎, 3rd National General Paediatric Conference, 12-14 September 2007. 中華醫學會第三次全國兒科基層醫師學術會議.

 

Chan G.C.F., Common childhood bleeding disorders., 3rd National Paediatric Conference, ZhengZhou, China. Sept 12-15, 2007. (Plenary Lecture). 2007.

 

Chan G.C.F., Chan S.H.S., Ho P.L., Wang L. and Ha S.Y., Effects of Different Forms of Iron Chelators on Bacteria Commonly found in Asian Children, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 36.

 

Chan G.C.F., Li C.B., Mo F.Y. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: Its impacts on BMT & tissue engineering. , 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港 28 June 2008, 2008.

 

Chan G.C.F., Li J., Mo I. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: its impacts on BMT & tissue engineering, 第十三屆全國小兒血液病學術會議, 湖南宜昌, 中國, 8-11 November 2007, 2007, 161-162.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., Epidemiology & Treatment Outcome of Childhood Ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group., 13th International Symposium on Pediatric Neuro-Oncology (ISPNO 2008), Chicago, Illnois, USA, June 29-July 2, 2008.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Ha S.Y. and Li C.K., Epidemiology & treatment outcome of childhood ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group, 13th International Symposium on Pediatric Neuro-Oncology. Chicago, USA, June 29-June 2, 2008.

 

Chan G.C.F., Epidemiology of childhood brain tumour in Hong Kong. , Brain 2008 & 5th Asian Pacific Multidisciplinary Meeting for Nervous System Diseases. Jan 18-19, 2008.. 2008.

 

Chan G.C.F., Infections in Thalassaemic Patients. , Annual General Meeting Lecture of the Hong Kong Society for the Study of Thalassaemia. March 12, 2008. . 2008.

 

Chan G.C.F., Infections in Thalassaemic patients, Hong Kong Society for the Study of Thalassaemia, Hong Kong, 12 March 2008. 2008.

 

Chan G.C.F., Management of Childhood Haemangioma, Lecture presentation for Annual Scientific Meeting 2008, Hong Kong Paediatric Haematology & Oncology Study Group, HK, 15 March 2008. 2008.

 

Chan G.C.F., Management of Childhood haemangioma. , Annual Scientific Meeting of the Hong Kong Paediatric Haematology & Oncology Study Group. March 15, 2008. (Symposium Lecture). 2008.

 

Chan G.C.F., 腦腫瘤治療新曙光, Public Lecture for: LKS Faculty of Medicine, HKU, 14 June 2008. 2008.

 

Chan G.C.F., Recent advances in the classification and management of childhood haemangioma., The 3rd Gaungdong Paediatric Oncology Society Annual Scientific Meeting. Gaungdong, China. Dec 8, 2007. (Plenary Lecture). 2007.

 

Chan G.C.F., Red cells disorders: What has been changed in diagnosis and treatment over the past 2 decades? , CME Lecture at Canossa Hospital. July 25, 2007. . 2007.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Li R.C.H., Ling S.C., Ha S.Y., Li C.K., Luk C.W., Lee A.C.W. and Li C.K., Review on childhood astrocytoma: The Hong Kong Paediatric Haematology / Oncology Study Group (HKPHOSG) Experience (1994 to 2006), 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 72.

 

Chan G.C.F., Symposium on Preservation of Fertility in Cancer Patients. , Hong Kong Society for Reproductive Medicine. Jan 20, 2008.. 2008.

 

Chan G.C.F., Targeted Therapy for Paediatric Cancers, 兒童腫瘤靶向治療, Guangzhou Paediatric Oncology Syposium. 第三屆廣東省小兒腫瘤學術研討會, 廣州, 中國, 8 December 2007, 2007-12-8, 2007, 4.

 

Chan G.C.F., Targeted Therapy in Paediatrics, The Federation of Medical Societies of Hong Kong, Hong Kong, 20 October 2007. 15.

 

Chan G.C.F., Targeted therapy for Paediatric Cancer. , "Targeted Therapy in Cancer” in Annual Scientific Symposium of the Federation’s Annual Scientific Meeting 2007. Oct 20, 2007.. 2007.

 

Chan G.C.F., Targeted therapy for Paediatric Cancer., The 3rd Gaungdong Paediatric Oncology Society Annual Scientific Meeting. Gaungdong, China. Dec 8, 2007. (Plenary Lecture). 2007.

 

Chan G.C.F., The current experience in managing childhood Myeloproliferative disorders and myelodysplastic syndrome., National Paediatric Haematology/ Oncology Biennial Meeting, Xiamen, China. Aug 9-12, 2007. (Plenary Lecture). 2007.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., The epidermiology and outcome of childhood brain tumour in Hong Kong: Report from the Hong Kong Paediatric Haematology Oncology Study Group, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 14.

 

Chan G.C.F., The immunological effects of beta-glucan & Lingzhi. , HKU TCM Workshop 2007. Hong Kong, 14 December 2007.. 2007.

 

Chan G.C.F., The immunomodulating effects of beta glucan on human immune and cancer cells. , 3rd International Congress on Complementary Medicine Research. Sydney, Australia. March 29-31, 2008. (Symposium Lecture). 2008.

 

Chan G.C.F., The immunomodulating effects of beta-glucan on human immune and cancer cells, 3rd International Congress of Complementary Medicine Research, Sydney, Australia, 29-31 March 2008. 15-16.

 

Chan G.C.F., The immunomodulatory effects of b-glucans on human immune and cancer cells, HKU TCM Workshop 2007, Hong Kong, 14 December 2007.

 

Chan G.C.F., Shing M.M.K., Luk C.W., Li R.C.H., Ling S.C., Li C.K. and Ha S.Y., Treatment outcome of neuroblastoma: The Hong Kong experience, 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港. 28 June 2008, 2008.

 

Chan G.C.F., Update on the management of hemangiomas & vascular malformations, 血管瘤及血管畸形治療進展, Guangzhou Paediatric Oncology Symposium. 第三屆廣東省小兒腫瘤學術研討會, 廣州, 中國, 8 December 2007, 2007-12-8, 2007, 6.

 

Chan G.C.F., Use of experimental treatments for metastatic neuroblastoma, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Chan G.C.F., 不同的探熱方法有什麼不同?, 香港兒科基金健康叢書–"兒童健康問題理想知", 香港兒科醫學會, Hong Kong, May 2008;p2-3., 2008, 2-3.

 

Chan G.C.F., 兒童怎樣才算是貧血?, 香港兒科基金健康叢書–"兒童健康問題理想知", 香港兒科醫學會, Hong Kong, May 2008;p33., 2008, 33.

 

Chan G.C.F., 嬰兒或兒童患營養性缺鐵貧血普遍嗎?, 香港兒科基金健康叢書–"兒童健康問題理想知", 香港兒科醫學會, Hong Kong, May 2008;p34., 2008, 34.

 

Chan G.C.F., 發燒的定義是什麼?, 香港兒科基金健康叢書–"兒童健康問題理想知", 香港兒科醫學會, Hong Kong, May 2008;p2., 2008, 2.

 

Chan G.C.F., 生說我是地中海貧血基因攜帶者,我會貧血嗎?病症會遺傳嗎?, 香港兒科基金健康叢書–"兒童健康問題理想知", 香港兒科醫學會, Hong Kong, May 2008;p35, 2008, 35.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum polysaccharides can induce human monocytic leukemic cells into dendritic cells with immunotolerogenic function., Blood 2007. 2007, 118(11):4208a.

 

Chan W.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley, International Immunology. England, Oxford University Press, 2007, 19 (7): 891-899.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum Polysaccharides Can Induce Human Monocytic Leukemia Cells into Dendritic Cells with Immunotolerogenic Function, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 301B.

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J.Y., Lau Y.L. and Yang M., Effects of Serotonin on Proplatelet Formation and F-actin Reorganization in Human Megakaryocytes, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 628a.

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J., Lau A.S.Y. and Yang M., Effects of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes. , Blood 2007. 2007, 118(11):628a.

 

Cheuk D.K.L., Lee T.L., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Chiang A.K.S., Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children, Journal of neurooncology. 2008, 86: 337-347.

 

Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46.

 

Cheuk D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid acinic cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer. 2008 ;50(3):636-9. 2008, 50(3): 636-9.

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Cheung K.W., Sze D.M.Y., Koo M.W.L. and Chan G.C.F., The Immunomodulatory Effects of Propolis from Different Origins on Human Immune Cells, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Cheung Y.F., Liang X., Chan G.C.F., Wong S.J. and Ha S.Y., Diastolic Myocardial Deformation is Associated with Myocardial Iron Load in Patients with Beta-Thalassaemia Major: A Speckle Tracking Echocardiographic Study, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasiorx (ICL670) on Arterial Function in Patients with Beta-Thalassaemia Major, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major, British Journal of Haematology. 2008, 141: 728-733.

 

Chow K.C., Chan G.C.F., Khong P.L., Shek T.W.H., Ha S.Y. and Lau Y.L., Primary Ki-1-positive anaplastic large cell lymphoma of the bone presented with spinal cord compression, Hong Kong Journal of Paediatrics. 2007, 12: 283-286.

 

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilic factors do not increase central venous catheter blockage in Chinese children with malignancy, Pediatr Blood & Cancer (Epub June 2008). 2008.

 

Fung K.L., Li J., Liang R.H.S. and Chan G.C.F., The Effect of Microtubule-targeting Chemotherapeutic Agents on the Surival of Bone-marrow Derived Mesenchymal Stem Cell, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Ha S.Y., Cheuk D.K.L., Ho M.H.K., Chiang A.K.S. and Chan G.C.F., Experience in Chelation Regimens adjusted According To Categorisation of Trancfusing-Dependent Thalassemic Patients Using Serium Ferritin and MRI Data, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 42.

 

He T., Kirk P., Firmin D.N., Lam W.M., Chu W.C.W., Au W.Y., Chan G.C.F., Tan R.S., Ng I., Biceroglu S., Aydinok Y., Fogel M.A., Cohen A.R. and Pennell D.J., Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment, Journal of Cardiovascular Magnetic Resonance. 2008, 10: 11.

 

Kwok M.K., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Is there a different pattern of second neoplasms among Chinese childhood cancer survivors?, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 39.

 

Lam D.S.T., Khong P.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Reversible encephalopathy induced by systemic high dose methotrexate, Hong Kong Journal of Paediatrics (new series). 2007, 12: 287-292.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Mak C.M., Siu T.S., Lam C.W., Chan G.C.F., Poon G.W.K., Wong K.Y., Low L.C.K., Tang N.L., Li S.K., Lau K.Y., Kwong N.S. and Tam S., Complete recovery from acute encephalopathy of late-onset ornithine transcarbamylase deficiency in a 3-year-old boy, Journal of Inherited Metabolic Disease. Springer, 2007, 30(6): 981.

 

Tong P.H., Man C.W.Y., Tsao G.S.W. and Chan G.C.F., Arsenic Trioxide Induced All Cycle Arrest in Neuroblastoma Cells with or without MYCN Over-Expression & the Response Had No Correlation with their Effect on Chromosomal Passenger Complex, Advances in Neuroblastoma Research 2008, Chiba, Japan, 21-24 May 2008. 140.

 

Tong P.H., Man C.W.Y., Tsao G.S.W. and Chan G.C.F., Arsenic Trioxide induced G2/M phase arrest in neuroblastoma cells with or without MYCN over-expression & the response had no correlation with their effect on chromosomal passenger complex., 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港. 28 June 2008, 2008.

 

Tong P.H. and Chan G.C.F., Sub-lethal Concentration of Arsenic Trioxide may Enhance Proliferation or Mitochondrial Activity of Arsenic Resistant Neuroblastoma Cell Lines, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Wong C.H., Yip H.K. and Chan G.C.F., Effect of Various Culture Surfaces on Human Mesenchymal Stem Cells, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Yuan X.J., Chan G.C.F., Chan S.K., Shek T.W.H., Kwong D.L.W., Wei W.I., Ha S.Y. and Chiang A.K.S., Treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children, Hong Kong Medical Journal. 2008, 14(2): 116-123.

 

Researcher : Chan KW

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Cheung Y.F., Huang G.Y., Chen S.B., Liu X.Q., Li X., Liang X.C., Huang M.R., Chen S., Huang L.S., Liu X.Q., Chan K.W. and Lau Y.L., Best poster presentation: Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Lee P.P.W., Jiang L.P., Wang X.C., Chan K.W., Tu W. and Lau Y.L., Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor b1 deficiency, European Journal of Pediatrics. Springer, 2008, 167: 231-232.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Wang M.C., Chan K.W., Wang X.C., Wang Y., Lau Y.L., Shum S.C. and Cheung N.Y., 嚴重聯合免疫缺陷病 I 例基因診斷及家系分析, 第四屆江、浙、滬兒科學術會會議, Nanjing, PRC, 15-17 November 2007, 2007.

 

Researcher : Chan KW

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Cheung Y.F., Huang G.Y., Chen S.B., Liu X.Q., Li X., Liang X.C., Huang M.R., Chen S., Huang L.S., Liu X.Q., Chan K.W. and Lau Y.L., Best poster presentation: Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Lee P.P.W., Jiang L.P., Wang X.C., Chan K.W., Tu W. and Lau Y.L., Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor b1 deficiency, European Journal of Pediatrics. Springer, 2008, 167: 231-232.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Wang M.C., Chan K.W., Wang X.C., Wang Y., Lau Y.L., Shum S.C. and Cheung N.Y., 嚴重聯合免疫缺陷病 I 例基因診斷及家系分析, 第四屆江、浙、滬兒科學術會會議, Nanjing, PRC, 15-17 November 2007, 2007.

 

Researcher : Chan LLY

List of Research Outputs

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Researcher : Chan MP

List of Research Outputs

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Interaction of IL-10 and Th1 Cytokines in Mycobacterial Evasion of Immunity, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of BCG-induced immune responses, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), 16-19 September 2007, Oxford, England. 2007.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of Mycobacteria-induced Immune Evasion: IFNg and IL-12 Suppression of BCG-induced IL-10 Expression, International Society for Interferon and Cytokine Research 2007 (abstract published in the “Journal of Intrerferon & Cytokine Research” Vol 27 No. 8 August 2007), Oxford, UK. 2007.

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Researcher : Chan PL

List of Research Outputs

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Researcher : Chan S

List of Research Outputs

 

Chan G.C.F., Li C.B., Mo F.Y. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: Its impacts on BMT & tissue engineering. , 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港 28 June 2008, 2008.

 

Chan G.C.F., Li J., Mo I. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: its impacts on BMT & tissue engineering, 第十三屆全國小兒血液病學術會議, 湖南宜昌, 中國, 8-11 November 2007, 2007, 161-162.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Researcher : Chan SHS

List of Research Outputs

 

Chan G.C.F., Chan S.H.S., Ho P.L., Wang L. and Ha S.Y., Effects of Different Forms of Iron Chelators on Bacteria Commonly found in Asian Children, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 36.

 

Researcher : Chan SY

Project Title:

Functional studies of the role of NAP79 in the development of the heart

Investigator(s):

Chan SY, Zhang JCL

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To test the function of NAP79 in heart development by the generation of null-mutant mice. The focus of the phenotype analysis will be on cardiomyocyte proliferation and terminal differentitation.

 

Project Title:

Expression and function of NAP79 during brain development.

Investigator(s):

Chan SY, Yick LW

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2005

 

Abstract:

Background: Our group has identified a novel 79 kDa nucleosome assembly protein, NAP79, from human heart cDNAs. We have generated transgenic lines of mice expressing human NAP79 in the heart and brain. Nucleosome assembly proteins (NAPs) deposit histones onto DNA, which is important in nucleosome remodelling during DNA replication and gene transcription, and in controlling mitotic events. A role of NAPs in inhibiting cell proliferation is demonstrated by the inactivation of NAP1-like-2 in mice, which leads to an opened neural tube, and exposed brain. These defects are associated with overproduction of neuronal precursor cells. A few months ago, NAP79 is found to form a complex with CASK and Tbr-1 to modulate the expression of NMDA receptor subunit 2B (NR2b) in cultured hippocampal neurons. NAP79 encodes a novel protein containing a conserved NAP domain, potential phosphorylation sites for casein kinase II, cyclin-dependent kinases, and cAMP- and cGMP-dependent kinases. During postnatal development, we have found that NAP79 expression in cardiomyocytes changes as they exit from the cell cycle. Furthermore, NAP79 arrests cell proliferation when transfected into HeLa cells or yeast. These data suggest that NAP79 plays a role in regulating the proliferation and differentiation of cardiomyocytes. Also, our northern and western blot data has shown that NAP79 is highly expressed in the adult brain but not in other organs. Like the heart, the adult brain consists mostly of non-dividing post-mitotic cells. Objectives: We hypothesize that (1) NAP79 is essential for switching off cell proliferation during brain development; and/or (2) NAP79 controls brain function through controlling the expression of specific target genes. In this proposal we seek to investigate the expression and function of NAP79 during the development of the mammalian central nervous system (CNS). We shall also characterize the cell types expressing human NAP79 in the transgenic mouse brain. For elucidation of gene function, phenotype analysis of the NAP79 transgenic animals including expression of target genes (eg. NR2b), behavioural, learning and memory test will form the basis of a new RGC proposal.

 

Project Title:

Characterisation of NAP79 transgenic mice

Investigator(s):

Chan SY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Objective: To determine the function of NAP79 in cardiomyocyte proliferation by analysing transgenic mice with prolonged expression of NAP79. Key issues and problems being addressed: Our group has identified a novel 79 kDa nucleosome assembly protein, NAP79, from human heart cDNAs [1]. Nucleosome assembly proteins (NAPs) deposit histones onto DNA, which is important in nucleosome remodelling during DNA replication and gene transcription, and in controlling mitotic events. In mice, we found that Nap79 transcripts are mainly expressed in the neonatal heart and brain. We have raised antibodies against NAP79 and found that the cardiac expression of NAP79 decreases dramatically during the neonatal period. This is of great interest since cardiomyocytes permanently withdraw from the cell cycle within the first 2 weeks in mice and within 3-6 months in humans, and so the number of proliferating cardiomyocytes gradually decline during these periods. Is NAP79 expressed only in proliferating cardiomyocytes and switched off once the cells exit the cell cycle? Our preliminary experiments to knock down Nap79 expression by siRNA in the myoblast cell line C2C12 have shown an effect on the rate of cell proliferation and the cells can no longer undergo terminal differentiation. Based on its domain structure, expression pattern and the effect of siRNA, we hypothesize that NAP79 plays a role in regulating the proliferation/ terminal differentiation of cardiomyocytes. There are two possible mechanisms of how NAP79 may fuction in controlling cardiomyocyte proliferation: 1. Expression of NAP79 is required to keep cardiomyocyte in the cell cycle. 2. The peak cardiac expression of NAP79 during the neonatal period is a signal for cell cycle exit/ terminal differentiation. If the first situation is correct, then prolonging the expression of NAP79 may delay cell cycle exit of cardiomyocytes. By contrast, increasing the level of NAP79 may cause earlier exit of cardiomyocytes from the cell cycle if the second mechanism is correct. To test our hypothesis, we have generated transgenic mice with a HA-tagged human NAP79 cDNA driven by cardiomyocyte specific promoters. This can both increase and prolong the cardiac expression of NAP79. We have obtained two transgenic lines which express the transgene as measured by RT-PCR in the neonatal and adult heart samples. Given the complex nature of cell cycle control in vivo, it is not surprising that our transgenic mice do not show an overt change in heart to body weight ratio. As in other reports on transgenic mice of cell cycle regulators (eg. cyclin D1, D2 and A2), expression of positive cell cycle regulators or even mitosis may be increased in the postnatal myocardium. This proposal aims at analysing cardiomyocyte proliferation in the neonatal period of our transgenic animals. We shall perform immunostaining and analyse the percentage of proliferating cardiomyocytes at around day 2 and day 10 after birth. Reference: 1. Sun G et al. Isolation of differentially expressed genes in human heart tissues (2002) Biochimica et Biophysica Acta - Mechanisms of disease 1588, 241 -246.

 

List of Research Outputs

 

Chan S.Y., Adjudicator for posters, 12th Research Postgraduate Symposium, Hong Kong, 14 December . 2007-12-14, 2007.

 

Chan S.Y., Organizing Committee, Frontiers in Biomedical Research, Hong Kong, 12 December. 12/2008, 2007.

 

Chan T.L. and Chan S.Y., Promoter Characterization of Testis Specific Protein, Y-linked Like 2 (Tspyl2), 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Chiu R.P.H. and Chan S.Y., Identification and Functional Studies of the Protein Interacting Partners of Human Testis-specific Protein Y-linked Like 2 (TSPYL2) Gene, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y. and Lau Y.L., Teaching and Learning Medical Genetics - Evaluation of an Interactive Genetics Workshop for Pediatric Clerkship Students, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 103.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y., Yang W. and Lau Y.L., Teaching and Learning Medical Genetics – An Interactive Genetics Workshop for Pediatric Clerkship Students , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Researcher : Chan TL

List of Research Outputs

 

Chan T.L. and Chan S.Y., Promoter Characterization of Testis Specific Protein, Y-linked Like 2 (Tspyl2), 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Researcher : Chan WK

List of Research Outputs

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum polysaccharides can induce human monocytic leukemic cells into dendritic cells with immunotolerogenic function., Blood 2007. 2007, 118(11):4208a.

 

Chan W.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley, International Immunology. England, Oxford University Press, 2007, 19 (7): 891-899.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum Polysaccharides Can Induce Human Monocytic Leukemia Cells into Dendritic Cells with Immunotolerogenic Function, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 301B.

 

Researcher : Chan WK

List of Research Outputs

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum polysaccharides can induce human monocytic leukemic cells into dendritic cells with immunotolerogenic function., Blood 2007. 2007, 118(11):4208a.

 

Chan W.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley, International Immunology. England, Oxford University Press, 2007, 19 (7): 891-899.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum Polysaccharides Can Induce Human Monocytic Leukemia Cells into Dendritic Cells with Immunotolerogenic Function, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 301B.

 

Researcher : Chau AKT

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of fallot, International Journal of Cardiology. 2007-9-12, Elsevier, 2007, 121: 155-162.

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Koo S.D., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Cardiovascular symptoms and signs in evaluating cardiac murmurs in children, Pediatrics International. 2008, 50: 145-149.

 

Researcher : Chen W

List of Research Outputs

 

Chen W., Wong V.C.N. and Liu W.L., Double Blind Randomized Control Trial of Real Electro-Acupuncture versus Sham Electro-acupuncture in Autism Spectrum Disorder (ASD), 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007.

 

Wong V.C.N., Chen W. and Liu W.L., Double Blind Randomized Control Trial of Acupuncture in Children with Autism Spectrum Disorder, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Researcher : Cheng M

List of Research Outputs

 

Cheng M., Xing B., Li C.B., Cheung B.K.W. and Lau A.S.Y., Interferon-gamma regulation of TNF-alpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells., Internatl J Cancer. 2007, 121: 1190-6.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Dysregulation of the Interferon-gamma Signal Transduction: Suppression of Jak/STAT Pathways and Implication for Opportunistic Infections, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 101.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Tat protein inhibits interferon-gamma signaling by suppressing STAT 1 activation: implications for AIDS pathogenesis and opportunistic infections, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Oxford, England, September 16-19. 2007.

 

Researcher : Cheuk DKL

List of Research Outputs

 

Cheuk D.K.L., Yeung W.F., Chung K.F. and Wong V.C.N., Acupuncture for insomnia (Review), Cochrane Database of Systematic Reviews. 2007, 3: CD005472.

 

Cheuk D.K.L., Lee T.L., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Chiang A.K.S., Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children, Journal of neurooncology. 2008, 86: 337-347.

 

Cheuk D.K.L., How predictive are predictors of remission of peanut allergy?, Journal of Allergy Clinical Immunology. 2008, 121(6): 1517.

 

Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46.

 

Cheuk D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid acinic cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer. 2008 ;50(3):636-9. 2008, 50(3): 636-9.

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Cheuk D.K.L., Tang I.W.H., Chan K.H., Woo P.C.Y., Peiris J.S.M. and Chiu S.S.S., Rhinovirus infection in hospitalized children in Hong Kong - A prospective study, The Pediatric Infectious Diseases Journal. 2007, 26: 995-1000.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Ha S.Y., Cheuk D.K.L., Ho M.H.K., Chiang A.K.S. and Chan G.C.F., Experience in Chelation Regimens adjusted According To Categorisation of Trancfusing-Dependent Thalassemic Patients Using Serium Ferritin and MRI Data, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 42.

 

Researcher : Cheung BKW

List of Research Outputs

 

Chan M.M., Cheung B.K.W., Li J.C. and Lau A.S.Y., Inhibition of Mycobacteria-induced IL-10 Expression by Exogenous Th-1 Cytokines, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Interaction of IL-10 and Th1 Cytokines in Mycobacterial Evasion of Immunity, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of BCG-induced immune responses, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), 16-19 September 2007, Oxford, England. 2007.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of Mycobacteria-induced Immune Evasion: IFNg and IL-12 Suppression of BCG-induced IL-10 Expression, International Society for Interferon and Cytokine Research 2007 (abstract published in the “Journal of Intrerferon & Cytokine Research” Vol 27 No. 8 August 2007), Oxford, UK. 2007.

 

Cheng M., Xing B., Li C.B., Cheung B.K.W. and Lau A.S.Y., Interferon-gamma regulation of TNF-alpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells., Internatl J Cancer. 2007, 121: 1190-6.

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Cheung B.K.W. and Lau A.S.Y., Mycobacterial Evasion of Immunity Via Cytokine Dysregulation: A Potential Role for Mitogen-Activated Protein Kinase Phosphatase-1, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, Hong Kong, 15 March. 2008.

 

Cheung B.K.W. and Lau A.S.Y., Mycobacterial evasion of immunity via cytokine dysregulation: a potential role for mitogen-activated protein kinase phosphatase-1, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Researcher : Cheung EWY

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007.

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of fallot, Heart Vessels. Springer, 2008, 3: 112-117.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 153.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation on Three Dimensional Left Ventricular Mycardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of fallot, International Journal of Cardiology. 2007-9-12, Elsevier, 2007, 121: 155-162.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., The Impact of Right Ventricular Dilation on Regional Left Ventricular Function in Patients After Tetralogy of Fallot Repair: A Novel Assessment by Speckle Tracking Echocardiography, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidatie stress in children later after Kawasaki disease: relationship with carotid atherosclerosis and stiffness, BioMed Central Pediatrics. 2008, 8(20): 1-8.

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidative Stress in Children Late After Kawasaki Disease: Relationship with Carotid Atherosclerosis and Stiffness, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Cheung Y.F., Liang X., Cheung E.W.Y. and Wong S.J., Real-Time Three-Dimensional Left Ventricular Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 104.

 

Chow P.C., Liang X., Lam W.W., Cheung E.W.Y. and Cheung Y.F., Abstract 1965: Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, American Heart Association 2007, Abstract in: Circulation 2007;116:II423-424. 2007, 116: 423-424.

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function, Heart. 2008, 94: 855-859.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y. and Cheung Y.F., Nowel Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Right Ventricular Physiology After Biventricular Repair of Pulmonary Atresia with Intact Ventricular Septum, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Rigth Ventricular Physiology after Biventricular Repair of Pulmonary Atresia and Intact Ventricular Septum, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 232.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dysynchrony after Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Oveerload, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 231.

 

Researcher : Cheung KW

List of Research Outputs

 

Cheung K.W., Sze D.M.Y., Koo M.W.L. and Chan G.C.F., The Immunomodulatory Effects of Propolis from Different Origins on Human Immune Cells, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Cheung PT

Project Title:

Delineation of molecular genetic basis for patients with idiopathic short stature

Investigator(s):

Cheung PT, Low LCK

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To determine the measurable biochemical profile in a group of patients with ISS and delineate the detailed genetic workup of the stated target genes.

 

List of Research Outputs

 

Cheung P.T., Iron, sense, and neurotoxicity, Hong Kong Medical Journal. 2007, 13(5): 412.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A new presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency Dopa Responsive Dystonia (DRD), 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C., Poon G.W.K., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly - transaldolase deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A rare presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency - Dopa Responsive Dystronia (DRD), A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Cheung P.T., Mak C.M., Siu S., Tam S. and Wong V.C.N., A study of cerebrospinal fluid neurotransmitters assay in children with undiagnosed neurological diseases in Hong Kong, Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society and HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Wang S., Wu E.X., Tam C.N., Lau H.F., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007.

 

Wong H.L., Wang M., Cheung P.T., Yao K.M. and Chan B.P., A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity, Biomaterials. Elsevier Ltd., 2007, 28: 5369-5380.

 

Yang J., Khong P.L., Wang Y., Chu A.C.Y., Ho S.L., Cheung P.T. and Wu E.X., Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury, Magnetic Resonance in Medicine. 2008, 59: 1329.

 

Zhou Y., Bhatia I., Cai Z., He Q., Cheung P.T. and Chiu J., Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins, J Proteome Research. 2008, 7: 2507.

 

Researcher : Cheung YF

Project Title:

CSX/NKX2.5 mutations in patients with pulmonary atresia and intact ventricular septum

Investigator(s):

Cheung YF, Chan SY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To determine the possible genetic cause of PAIVS, which is a relatively common cyanotic congenital heart disease in this locality.

 

Project Title:

Development of a multimedia tool for teaching of paediatric cardiology

Investigator(s):

Cheung YF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Run Run Shaw Research and Teaching Endowment Fund - Teaching Grants

Start Date:

04/2004

 

Abstract:

To improve the knowledge on congenital heart disease of medical students; thier skills in the evaluation of children with congenital heart disease, and their skills in counseling of parents of paediatric cardiac patients.

 

Project Title:

Modulating effects of body defense molecule and inflammatory gene polymorphisms on arterial stiffness in Kawasaki disease

Investigator(s):

Cheung YF, Lau YL

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To test the hypothesis that polymorphisms of these candidate genes, in isolation or combination, modulate systemic arterial stiffness in patients with a history of KD.

 

Project Title:

Association and Linkage Studies Between Arterial Stiffness and the Fibrillin-1 Gene

Investigator(s):

Cheung YF, Lau YL, Sham PC

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Arterial stiffness is recently recognized as an independent cardiovascular risk factor. With arterial stiffening, the left ventricular afterload is increased while coronary perfusion is altered. The secondary increase in pulse pressure has further been shown to be an independent predictor of cardiovascular mortality and future cardiovascular events. Although arterial stiffening has traditionally been regarded as part of the normal aging process, there is growing evidence that it may precede clinical disease and predict a higher risk for developing atherosclerosis, hypertension and stroke. Recently, the genetic aspect of arterial stiffness is beginning to unveil. In particular, there is a growing body of evidence that suggests a contributory role of genetic variations in extracellular matrix proteins to arterial stiffening. Fibrillin-1, being a matrix glycoprotein and the principal constituent of microfibrils that provide load-bearing and anchoring functions within the arterial wall, is particularly relevant in this context. Indeed, mutation and polymorphism of the fibrillin-1 gene has been associated with aortic stiffening in patients with Marfan syndrome and brachial pulse pressure in a healthy middle-aged male population, respectively. Nonetheless, whether variations in the fibrillin-1 genotype contribute to arterial stiffness in the general population have hitherto remained unknown.The primary objective of the proposed study is to test the hypothesis that arterial stiffness in the general population is associated with variations in the fibrillin-1 genotype. To test the hypothesis, sibling pair association and linkage studies between arterial stiffness and fibrillin-1 gene will be performed. The central (aortic and carotid) and peripheral (brachio-radial) arterial stiffness will be related to demographic variables, cardiovascular risk factors and a variable nucleotide tandem repeat polymorphism in intron 28 of the fibrillin-1 gene. Additionally, the single nucleotide polymorphism at intron C in the upstream region of the fibrillin-1 gene will be determined. Based on findings of these studies, the following issues will be addressed:- heritability of central and peripheral conduit arterial stiffness- association between variations in fibrillin-1 genotypes and arterial stiffness- linkage between fibrillin-1 gene and arterial stiffness- gene-environment interaction of fibrillin-1 genotypic variations in relation to arterial stiffness

 

Project Title:

Impact of iron overloding on left ventricular torsion in patients with beta-thalassaemia major

Investigator(s):

Cheung YF, Chan GCF

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

While cardiac dysfunction secondary to iron overload in patients with beta-thalassaemia major is well documented, the left ventricular (LV) function usually remains relatively normal as assessed by conventional echocardiograhic imaging until late in the cardiomyopathic process. These echocardiographic indices are derived primarily from the short- and long-axis function of the left ventricle. The relative insensitivity of these conventional, load-dependent indices of systolic and diastolic LV function is in part related to the fact that beta-thalassaemia major represents a high-output anaemic state, being generated by the volume-loaded ventricles to maintain a high cardiac output in the presence of a low systemic vascular resistance. Recent research in cardiac mechanics is moving from short- and long-axis LV function to three-dimensional ventricular deformation, notably LV torsional mechanics. The torsional deformation of the left ventricle is characterized by systolic twisting and diastolic untwisting about its long axis as a result of the opposite rotation of the cardiac apex and base. Left ventricular torsion plays an important role with respect to LV ejection and filling. More important, LV torsion has been shown to relate closely to alterations of sarcomeric proteins in experimental cardiomyopathy models. Ultrastructural alteration of the extracellular matrix proteins may result in subtle changes in myocardial function that are not evident with the conventional global ventricular function measurements. Hence, the effects of free iron increase within the cardimyocytes, which causes oxidative membrane damage and alterations in gene expression, may be reflected by changes in LV twisting and untwisting before the changes are apparent in indices of global LV function. We therefore hypothesized that iron-overloading in patients with beta-thalassaemia major has a negative impact on LV torsional mechanics both at rest and during exercise stress. The proposed study is to test the hypothesis by examining the LV torsion and torsional velocity by speckle tracking echocardiography in patients with beta-thalassaemia major at rest and during exercise stress and comparing the LV torsional mechanics to those of age and sex-matched controls. This proposed study would address the following issues:i) the impact of iron overloading on the resting and exercise-stressed LV torsional mechanics in patients with beta-thalassaemia major,ii) the relation between LV torsional indices and myocardial iron load,iii) the relation between indices of LV torsion and conventional and tissue Doppler indices of LV systolic and diastolic function, and iv) the impact of systemic arterial stiffening, demonstrated to occur in patients with beta-thalassaemia major previously by our group, on LV torsion.

 

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007.

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of fallot, Heart Vessels. Springer, 2008, 3: 112-117.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 153.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation on Three Dimensional Left Ventricular Mycardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of fallot, International Journal of Cardiology. 2007-9-12, Elsevier, 2007, 121: 155-162.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., The Impact of Right Ventricular Dilation on Regional Left Ventricular Function in Patients After Tetralogy of Fallot Repair: A Novel Assessment by Speckle Tracking Echocardiography, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Cheung Y.F., Advice on Physical Activities for Children & Adolescent with Cardiac Problems, Updates Series on Child Health 2007 - Session IV. 2007.

 

Cheung Y.F., Huang G.Y., Chen S.B., Liu X.Q., Li X., Liang X.C., Huang M.R., Chen S., Huang L.S., Liu X.Q., Chan K.W. and Lau Y.L., Best poster presentation: Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Chairman - Oral Presentation, ASPR Research Network: Pediatric Cardiology, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 2008.

 

Cheung Y.F., Chairperson of the oral session entitled: "Cardiology 2", 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 2007.

 

Cheung Y.F., Coarctation of the aorta: What are the late vascular implications, 3rd Annual Toronto Symposium "Contemporary Questions in Congenital Heart Disease: The Left Heart", organized by the Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada. 2007.

 

Cheung Y.F., Liang X., Chan G.C.F., Wong S.J. and Ha S.Y., Diastolic Myocardial Deformation is Associated with Myocardial Iron Load in Patients with Beta-Thalassaemia Major: A Speckle Tracking Echocardiographic Study, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasiorx (ICL670) on Arterial Function in Patients with Beta-Thalassaemia Major, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major, British Journal of Haematology. 2008, 141: 728-733.

 

Cheung Y.F., Emerging echocardiographic techniques for assessment of right ventricular function in congenital heart disease, 第十一次廣東省暨首屆省港澳超聲醫學學術交通流大會， 廣東省醫學會超聲醫學分會, Guangzhou, PR China, 1-2 December 2007, 2007.

 

Cheung Y.F., Evaluation of RV Function by Echocardiography, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 123.

 

Cheung Y.F., Faculty Teaching Medal , Li Ka Shing Faculty of Medicine, The University of Hong Kong . 2007.

 

Cheung Y.F., How does the LV react to changes in the arteries and vice versa?, 3rd Annual Toronto Symposium "Contemporary Questions in Congenital Heart Disease: The Left Heart", organized by the Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada. 2007.

 

Cheung Y.F., Invited panelist of Panel Discussion of Epidemiology Data in Some Other Asian countries, Ninth International Kawasaki Disease Symposium, Taipei, Taiwan, 10 April 2008. 2008.

 

Cheung Y.F., Iron chelation and vascular function in patients with beta-thalassaemia major, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007.

 

Cheung Y.F., Kawasaki Disease in Hong Kong, 2000-2007, Abstract in Ninth International Kawasaki Disease Symposium, Taipei, Taiwan, 10-12 April 2008. 54-55.

 

Cheung Y.F., Kawasaki disease: what happens to the blood vessels, 3rd Annual Toronto Symposium "Contemporary Questions in Congenital Heart Disease: The Left Heart", organized by the Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada. 2007.

 

Cheung Y.F., Moderator of Oral presentation: Cardiac Imaging / Evaluation, Ninth International Kawasaki Disease Symposium, Taipei, Taiwan, 10 April 2008. 2008.

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidatie stress in children later after Kawasaki disease: relationship with carotid atherosclerosis and stiffness, BioMed Central Pediatrics. 2008, 8(20): 1-8.

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidative Stress in Children Late After Kawasaki Disease: Relationship with Carotid Atherosclerosis and Stiffness, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Cheung Y.F., Programming of Vascular Function In-Utero, Joint Maternal Fetal Medicine Grand Round, Kwong Wah Hospital, 2007. 2007.

 

Cheung Y.F., Progressive aortic root dilation after surgical repair of tetralogy of Fallot, Biannual Scientific Meeting of the Shanghao Children’s Medical Centre “Update on diagnosis and treatment for complex congenital heart disease”, Shanghai, China. 2007.

 

Cheung Y.F., Liang X., Cheung E.W.Y. and Wong S.J., Real-Time Three-Dimensional Left Ventricular Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 104.

 

Cheung Y.F., Seijong Young Investigator Award: Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 2008.

 

Cheung Y.F., 第十六章, 右心室衰竭, 小兒心力衰竭, 北京, 北京, 人民衛生出版社, 2008, 16: 137-146.

 

Chow P.C., Liang X., Lam W.W., Cheung E.W.Y. and Cheung Y.F., Abstract 1965: Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, American Heart Association 2007, Abstract in: Circulation 2007;116:II423-424. 2007, 116: 423-424.

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function, Heart. 2008, 94: 855-859.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y. and Cheung Y.F., Nowel Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Koh C., Yung T.C., Lun K.S. and Cheung Y.F., Left Ventricular Noncompaction in Children, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Koo S.D., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Cardiovascular symptoms and signs in evaluating cardiac murmurs in children, Pediatrics International. 2008, 50: 145-149.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Right Ventricular Physiology After Biventricular Repair of Pulmonary Atresia with Intact Ventricular Septum, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Rigth Ventricular Physiology after Biventricular Repair of Pulmonary Atresia and Intact Ventricular Septum, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 232.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dysynchrony after Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Oveerload, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 231.

 

Man B.L. and Cheung Y.F., Plasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure, Heart Vessels. Springer, 2007, 22: 398-403.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Researcher : Chiang AKS

Project Title:

Experimental immunotherapy of tumours

Investigator(s):

Chiang AKS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Research Initiation Programme

Start Date:

04/2001

 

Abstract:

To develop strategies in enhancing the host immune response against tumours.

 

Project Title:

Genetic studies of tubercubosis

Investigator(s):

Chiang AKS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

03/2002

 

Abstract:

To host susceptibility genes in tubercubosis; to study pharmacogenomics in anti-tubercubosis drug metabolism.

 

Project Title:

Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children

Investigator(s):

Chiang AKS, Chan KH

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

 

Abstract:

An unresolved issue in EBV immunology concerns the relationship between clinical IM-like symtoms, virus DNA load and CD8+ T cell lymphocytosis; Acute IM in adolescents is associated with large expansions of EBV lytic epitope reactivities which are followed by a later expansion of latent epitope responses. The magnitude of the EBV lytic and latent epitope reactivities would be studied and compared in both IM and non-IM patients; likewise, is there a difference in the rate of emergence of latent epitope responses bewteen the IM and non -IM patients? The kinetics and evolution of the EBV epitope-specific cytotoxic T-lymphocyte (CTL) responses from primary to persistent phases of EBV infection would be compared between the two groups of children.

 

Project Title:

Prospective study of Epstein-Barr virus (EBV) strains in primary EBV infection

Investigator(s):

Chiang AKS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study the occurrence of Epstein-Barr virus (EBV) diversity and coinfection in a prospective study of primary Epstein-Barr virus infection in Chinese children.

 

Project Title:

Longitudinal study of Epstein-Barr virus specific antibody responses in childhood infectious mononucleosis

Investigator(s):

Chiang AKS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

The purpose of the proposed study is to compare the evolution of Epstein-Barr virus (EBV) specific antibody responses in a longitudinal followup study of symptomatic and asymptomatic primary EBV infection. What is known about EBV antibody responses in the literature? Epstein-Barr virus (EBV) infects greater than 90% of all human populations and establishes a lifelong persistence within the host. Primary infections by EBV may remain silent or induce a self-limiting lymphoproliferative disorder, infectious mononucleosis (IM). EBV-encoded antigens are divided into those expressed in the viral replicative cycle, i.e., the viral capsid antigen (VCA) and the early amtigens (EA) of the diffuse (D) and the restricted (R) varieties and those expressed in the viral latent cycle, the EBV-determined nuclear antigen (EBNA). The different timing of emergence between the antibodies to VCA and EA and those to EBNA indicates that the two sets of antigens are likely expressed on separate types of cells which become available to stimulate antibody responses under different circumstances. The laboratory diagnosis of EBV infection is based on serological tests to detect both specific antibodies to EBV antigens (1, 2) and heterophile antibodies (3, 4). At the onset of symptoms of IM, the humoral response to EBV infection is characterized by the presence of VCA IgM antibodies and the concurrent rise of VCA IgG antibodies (5). Antibodies to diffuse early antigen (anti-EA-D) are transitory and are detected in about 80% of infected persons. Antibodies to EA-R may become detectable in protracted cases of the disease after the anti-D titres have subsided. Anti-EBNA IgG can usually be detected at a later stage at several weeks to months after the the onset of symptoms. The majority of adult IM patients also develop IgM heterophile antibodies of the Paul-Bunnell type but the reason for their transient emergence is unknown. However, these heterophile antibodies are absent in the majority of children under 4 years of age (6). The antibody responses in silent primary EBV infections (more frequently occurred in children than adults) largely conform to those seen in IM except that antibodies to the EA complex are directed against R instead of D (7, 8). The early EBV-specific IgG antibody response after primary infection is made up of low avidity antibodies. The avidity increases in the few weeks to several months after the infection (9, 10). This property of the humoral IgG response has been employed in serological assays to distinguish between primary and re-infection or reactivation of different viruses such as rubella, CMV and parvovirus (11, 12, 13). Key issues: The pattern of antibody responses and the antibody levels to EBV-encoded antigens are largely derived from cross sectional studies of large number of individuals. Longitudinal serology data of persons recovering from IM is seldom available and information on the humoral response in asymptomatic EBV infection is scanty. I have followed a large number of Chinese children presenting with infectious mononucleosis and some children who are found to have asymptomatic primary EBV infection from the time of onset of infection through convalescence to persistence. It offers an opportunity to compare the natural evolution of antibody responses against EBV in symptomatic and asymptomatic infections. Project objectives: 1. To define the evolution of the humoral response against a human persistent virus. 2. To study the maturation of the humoral response against a persistent virus in terms of antibody avidity. 3. To compare the magnitude and the quality of the humoral response against viral lytic and latent EBV antigens from acute phase through convalescent to persistent phase in symptomatic and asymptomatic infections. References: 1.Henle W and Henle G: Epstein-Barr virus specific serology in immunologically compromized individuals. Cancer Res 41: 4222-4225, 1981 2.Henle W and Henle G: Immunology of Epstein-Barr virus. In: B, Roizman (Ed.), The Herpsesviruses, Vol. 1. Plenum Publishing Corp., Ne York, pp 209-252, 1982 3.Paul JR and Bunnell WW: The presence of heterophile antibodies in infecetious mononucleosis. Am J Med Sci 183: 90-104, 1932 4.Davidsohn I and Lee CL: The clinical serology of infectious mononucleosis. In: RL Carter and HG Penman (Eds.), Infectious Mononucleosis. Blackwell Scientific Publications, Ltd., Oxford, pp 177-200, 1969 5.Okano M, Thiele GM, Davis JR, Grierson HL, Purtilo DT: Epstein-Barr virus and human diseases: recent advances in disgnosis. Clin Microbiol Rev 1: 300-312, 1988 6.Sumaya CV: Infectious mononucleosis and other EBV infections: diagnostic factors. Lab Manag 24: 37-45, 1986 7.Biggar RJ, Henle G, Bocker J, Lennette ET, Fleisher G, Henle W: Primary Epstein-Barr virus infections in African infacnts. II. Clinical and serological obsevations during seroconversion. Int J cancer 22: 244-250, 1978 8.Fleisher G, Henle W, Henle G, Lennette ET, Biggar RJ: Primary Epstein-Barr virus infection in American infants: clinical and serological observations. J Infect Dis 139: 553-558, 1979 9.Inouye S, Hasegawa A, MAtsuno S, Katwo S: Changes in antibody avidity after virus infections: detection by an immunosorbent assay in which a mild protein-denaturing agent is employed. J Clin Microbiol 20: 525-529, 1984 10.Kocks C and Rajewsky K: Stepwise intracloncal maturation of antibody affinity through somatic hypermutation. Proc Nat Acad Sci USA 85: 8206-8210, 1988 11.Thomas HIJ and Morgan-Capner P: Rubella-specific IgG subclass avidity and its role in differenetiation between primary rubella and rubella reinfection. Epidemiol Infect 101: 591-598, 1988 12.Lutz E, Ward KN, Gray JJ: Maturation of antibody avidity after primary human cytomegalovirus infection is delayed in immunosuppressed solid organ transplant patients. J Med Virol 44: 317-322, 1994 13.Gray JJ, Cohen BJ, Dresselberger U: Detection of human parvirus B19-specific IgM and IgG sntibodies using a recombinant viral VP1 antigen expressed in insect cells and estimation of time of infection by testing for antibody avidity. J Virol Methods 44: 11-24, 1993

 

List of Research Outputs

 

Cheuk D.K.L., Lee T.L., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Chiang A.K.S., Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children, Journal of neurooncology. 2008, 86: 337-347.

 

Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46.

 

Cheuk D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid acinic cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer. 2008 ;50(3):636-9. 2008, 50(3): 636-9.

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Chiang A.K.S., Contemporary treatment of paediatric lymphoma, 兒童淋巴瘤的現化治療, 第三屆廣東省小兒腫瘤學術研討會, 廣州, 中國, 8 December 2007, 2007-12-8, 2007, 8.

 

Chiang A.K.S., Contemporary treatment of paediatric lymphoma, 3rd Guangzhou Paediatric Oncology Symposium, Guangzhou, China, December 8. 2007.

 

Chiang A.K.S., Epstein-Barr Virus and Lymphoproliferative Disease, The National Continuing Medical Education Class—Hot-points and Difficulties in the Clinical Research of Pediatric Hematology/Oncology Diseases, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, May 12-18. 兒童血液/腫瘤疾病臨床研究熱點及難點, 2008.

 

Chiang A.K.S., Epstein-Barr Virus and Lymphoproliferative diseases, The National Continuing Medical Education Class - Hot-points and Difficulties in the Clinical Research of Pediatric Hematology/Oncology Disease, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PRC, 12-16 May 2008.

 

Chiang A.K.S., Paediatric lymphomas: subtypes and treatment strategies, 兒童淋巴瘤的亞型和治療策略, The National Continuing Medical Education Class—Hot-points and Difficulties in the Clinical Research of Pediatric Hematology/Oncology Disease, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, May 12-18. 兒童血液/腫瘤疾病臨床研究熱點及難點, 2008.

 

Chiang A.K.S., Paediatric lymphomas: subtypes and treatment strategies, The National Continuing Medical Education Class - Hot-points and Difficulties in the Clinical Research of Pediatric Hematology/Oncology Disease, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PRC, 12-16 May 2008.

 

Chiang A.K.S. and Yuan X.J., Treatment outcome and adverse factors of rhabdomyosarcoma in Hong Kong Chinese children, 39th Annual Congress of the International Society of Paediatric Oncology (SIOP 2007), 29-31 October 2007, Mumbai, India. 2007, 488.

 

Chu S.F., Tam C.M., Wong W.H.S., Kam K.M., Lau Y.L. and Chiang A.K.S., Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese, Genes and Immunity. Nature, 2007, 8: 475-479.

 

Ha S.Y., Cheuk D.K.L., Ho M.H.K., Chiang A.K.S. and Chan G.C.F., Experience in Chelation Regimens adjusted According To Categorisation of Trancfusing-Dependent Thalassemic Patients Using Serium Ferritin and MRI Data, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 42.

 

Hui K.F., To K.W. and Chiang A.K.S., The Effect of Histone Deacetylase Inhibitors on Lytic Cycle Activation of Epstein-Barr Virus (EBV) in EBV-associated Malignancy, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Kwok M.K., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Is there a different pattern of second neoplasms among Chinese childhood cancer survivors?, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 39.

 

Lam D.S.T., Khong P.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Reversible encephalopathy induced by systemic high dose methotrexate, Hong Kong Journal of Paediatrics (new series). 2007, 12: 287-292.

 

Xu X., Chan K.H. and Chiang A.K.S., Development of Latent and Lytic Epstein-barr Virus (EBV)-specific CD8+ Cytotoxic Lymphocyte Responses in Primary EBV Infection, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14, 158.

 

Yuan X.J., Chan G.C.F., Chan S.K., Shek T.W.H., Kwong D.L.W., Wei W.I., Ha S.Y. and Chiang A.K.S., Treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children, Hong Kong Medical Journal. 2008, 14(2): 116-123.

 

Researcher : Chik SCC

List of Research Outputs

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H. and Lau A.S.Y., Application of Genomics and cell signaling technologies to investigate traditional Chinese medicine: Panex Ginseng and its immunomodulatory effects, NHClaims 2007 Congress, Naantali, Finland, November 7-9. 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H., Rong J., Tam P.K.H. and Lau A.S.Y., Application of Platform Technologies to Investigate the Immunomodulatory Effects of Ginseng, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Tam P.K.H. and Lau A.S.Y., Application of platform technologies to investigate the immunomodulatory effects of Ginseng, 4th International Think Tank Forum, Faculty of Medicine, The University of Hong Kong, November 14-16. 2007.

 

Liu C., Chan L.K.Y., Chik S.C.C. and Lau A.S.Y., Identification of multiple markers for phylogenetic and DNA barcoding studies for medicinal plants, The Second International Barcode Conference. 2007.

 

Researcher : Chim S

List of Research Outputs

 

Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology. 2008, 13(4): 322-330.

 

Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology (Carlton). 2008, 13(4): 322-30.

 

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chim S., Fung S.H., Lo S.H.K., Lai K.N. and Chan K.W., Renal Pathology after Haematopoietic Stem Cell Transplantation (HSCT): A study of 13 patients, 24th World Congress of Pathology and Laboratory Medicine, 20-24 August 2007, Kuala Lumpur, Malaysia. 2007.

 

Researcher : Chiu RPH

List of Research Outputs

 

Chiu R.P.H. and Chan S.Y., Identification and Functional Studies of the Protein Interacting Partners of Human Testis-specific Protein Y-linked Like 2 (TSPYL2) Gene, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Researcher : Chiu SSS

Project Title:

Streptococcus pneumoniae carriage in young children in Hong Kong

Investigator(s):

Chiu SSS, Ho PL

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Health Services Research Fund - Full Grants

Start Date:

10/1999

 

Abstract:

To study the serotypes and the incidence of antibiotic resistant Streptococcus pneumoniae in young children in the community.

 

Project Title:

A population based study of hospitalization disease burden for respiratory viral infections in children

Investigator(s):

Chiu SSS, Lau YL, McGhee SM, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To define the population based disease burden of influenzavirus and other respiratory viruses including RSV, adenovirus, parainfluenzae types I,II and III, rhinovirus, hMPV and the newly discovered SARS associated coronavirus in children hospitalized for acute respiratory infections; to define the role of influenza A in children hospitalized for febrile seizures and encephalopathy; to define the impact of these respiratory viruses on children with asthma exacerbations; to document the socio-economic impact of these respiratory viral infections on families with children hospitalized in Hong Kong; to perform phylogenetic analysis of hMPV in Asia.

 

List of Research Outputs

 

Chan K.H., Peiris J.S.M., Lim W., Nicholls J.M. and Chiu S.S.S., Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in children , Journal of Clinical Virology. 2008, 42(1): 65-9.

 

Cheuk D.K.L., Tang I.W.H., Chan K.H., Woo P.C.Y., Peiris J.S.M. and Chiu S.S.S., Rhinovirus infection in hospitalized children in Hong Kong - A prospective study, The Pediatric Infectious Diseases Journal. 2007, 26: 995-1000.

 

Chiu S.S.S., Influenza in Children--a Brief Summary of Recent Work Done at HKU, Celebrating 120 Years of Medical Education: Explore the World of Medicine. Public Lecture Series Two. 2007.

 

Chiu S.S.S., Ho P.L., Chow K.H., Yuen K.Y. and Lau Y.L., Nasopharyngeal Carriage of Antimicrobial-Resistant Streptococcus pneumoniae among Young Children Attending 79 Kindergartens and Day Care Centers in Hong Kong, Health Research Symposium 2007: Building Bridges between Research, Practice & Policy, 29 September 2007.

 

Chiu S.S.S., Reviewer (Since 1994), Journal of Infectious Diseases. 2008.

 

Chiu S.S.S., Reviewer (Since 2003), Hong Kong Medical Journal. 2008.

 

Chiu S.S.S., Reviewer (Since 2004), Pediatrics International. 2008.

 

Chiu S.S.S., Reviewer (Since 2005), Journal of Clinical Virology. 2008.

 

Chiu S.S.S., Reviewer (Since 2006), Brain and Development. 2008.

 

Chiu S.S.S., Reviewer (Since 2006), Vaccine. 2008.

 

Chiu S.S.S., Reviewer (Since 2007), Pediatrics. 2008.

 

Chiu S.S.S., Reviewer (Since 2008), Journal of Pediatrics. 2008.

 

Chiu S.S.S., Reviewer, Hong Kogn Journal of Paediatrics. 2008.

 

Chiu S.S.S., Reviewer, Journal of Medical Virology. 2008.

 

Chiu S.S.S., 藥物及疫苗篇, 兒童健康問題「理」想知, 新雅文化事業有限公司, 2008, 102,107,109.

 

Ho P.L., Chiu S.S.S., Chow K.H., Mak C.K. and Lau Y.L., Pediatric hospitalization for pneumococcal diseases preventable by 7-valent pneumococcal conjugate vaccine in Hong Kong, Vaccine. 2007, 25: 6837-6841.

 

Wong C.M., Yang L., Chan K.P., Chiu S.S.S., Lam T.H., Hedley A.J. and Peiris J.S.M., Modeling the disease burden of influenza in the topical/subtropical regions (powerpoint presentation), WPRO Informal Consultation on Protocols for Influenza Disease burden Studies 2007, 12-13 November 2007, Manila. Manila, WHO/WPRO, 2007.

 

Researcher : Chong CY

List of Research Outputs

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Researcher : Chong WP

List of Research Outputs

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Researcher : Chow PC

List of Research Outputs

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidatie stress in children later after Kawasaki disease: relationship with carotid atherosclerosis and stiffness, BioMed Central Pediatrics. 2008, 8(20): 1-8.

 

Cheung Y.F., Karmin O., Woo C.W.H., Armstrong S., Siow Y.L., Chow P.C. and Cheung E.W.Y., Oxidative Stress in Children Late After Kawasaki Disease: Relationship with Carotid Atherosclerosis and Stiffness, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Chow P.C., Liang X., Lam W.W., Cheung E.W.Y. and Cheung Y.F., Abstract 1965: Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, American Heart Association 2007, Abstract in: Circulation 2007;116:II423-424. 2007, 116: 423-424.

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function, Heart. 2008, 94: 855-859.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y. and Cheung Y.F., Nowel Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Researcher : Chu SF

List of Research Outputs

 

Chu S.F., Tam C.M., Wong W.H.S., Kam K.M., Lau Y.L. and Chiang A.K.S., Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese, Genes and Immunity. Nature, 2007, 8: 475-479.

 

Researcher : Chung BHY

Project Title:

Identification of TGFBR2 Mutations in Chinese patients with Marfan Syndrome (MFS) using DHPLC (Denaturing High Performance Liquid Chromatography)

Investigator(s):

Chung BHY, Lau YL, Lun KS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Marfan syndrome (MFS) is an autosomal dominant mulit-systemic connective tissue disease with involvement of cardiovascular, musculo-skeletal, ocular and many other systems. It has an estimated incidence of up to 1: 5,000 (1). Among all the clinical features, progressive aortic root dilatation and aortic dissection is the most serious one and it represents the predominant cause of death in over 90% of patients. The first genetic defect identified for MFS is the fibrillin-1(FBN1) gene located in the long arm of chromosome 15. Up to date, there are at least 562 published FBN1 mutations (2) which scattered over the 200 kb FBN1 gene. In our previous study (3), 24 mutations in FBN1 gene could be identified in 66 probands with MPS (n=17 fulfil Ghent criteria, 14/17 FBN1 mutation positive) and marfan-like phenotypes (1). In 1991, a second disease-locus for MFS was mapped to 3p24.2-p25 in a large French family and later found to encode the transforming growth factor-beta-receptor type II (TGFBR2) gene in 2004 (4). This has provided the first genetic evidence of a link between abnormal TGF-beta signalling and human connective tissue disorders. Several functional studies have been performed following this discovery and have increased our understanding of the pathogenesis of MFS and its related disroders e.g. Loeys-Dietz syndrome (5). FBN1 mutations are shown to be positive in up to 90% probands who fulfil Ghent diagnostic criteria (2). And the study by Matyas et al, have shown that TGFBR2 mutations could be identified in ~10% of non-FBN1-patients with MFS-related disorders (6). Probands with TGFBR2 mutations have comparable clinical features with those with FBN1 mutations but often with milder ocular abnormalities and infrequent dural ectasia (2,4,7). From our local Chinese cohort, FBN1 mutations were detected only in 36% probands (76% in those fulfilling Ghent criteria) (3). Analysis of their phenotypic characteristics reveals that our patients have relatively infrequent ocular abnormalities (9%) and dural ectasia (6%) . We hypothesize that TGBFR2 mutations could be a major underlyinig genetic abnormality in Chinese MFS patients and our objective is to examine the mutation spectrum of TGFBR2 in non-FBN1 Chinese patients with MFS and its related phenotypes. References: 1. Pyeritz RE. The Marfan syndrome. Annu Rev Med 2000; 51: 481-510. 2. Boileau C, Jondeau G, Mizuguchi T, Matsumoto N. Molecular genetics of Marfan syndrome. Curr Opin Cardiol 2005; 20:194-200. 3. Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li S., Lun K.S., Chan H.C., Or S.F., and Lau Y.L. Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes. Joint 6th Human Genome Organization (HUGO) Pacific Meeting and the 7th Asia-Pacific Human Genetics Conference, Taipei, Taiwan, 6-10 March 2006 (poster presentation). 4. Mizuguchi T, Collod-Beroud G, Akiyama T, Abifadel M, Harada N, Morisaki T, Allard D, Varret M, Claustres M, Morisaki H, Ihara M, Kinoshita A, Yoshiura K, Junien C, Kajii T, Jondeau G, Ohta T, Kishikno T, Furukawa Y, Nakamura Y, Niikawa N, Boileau C, Matsumoto N. Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Gen 2004; 36(8):855-860. 5. Singh KK, Rommel K, Mishra A, Karck M, Haverich A, Schmidtke J, Arslan-Kirchner M. TGFBR1 and TGFBR2 mutations in patients with features of marfan syndrome and Loeys-Dietz syndrome. Hum Mutat 2006; 27(8):770-777. 6. Matyas G, Arnold E, Carrel T, Baumgartner D, Boileau C, Berger W, Steinmann B. Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in marfan syndrome-related disorders. Hum Mutat 2006; 27(8):760-769. 7. Disabella E, Grasso M, Marziliano N, Ansaldi S, Lucchelli C, Porcu E, Tagliani M, Pilotto A, Diegoli M, Lanzarini L, Malattia C, Pelliccia A, Ficcadenti A, Gabrielli O, Arbustini E. Two novel and one known mutation of the TGFBR2 gene in marfan syndrome not associated with FBN1 gene defects. Eur J Hum Gen 2006;14:34-38.

 

List of Research Outputs

 

Chung B.H.Y. and Chitayat D., Brachytelephalangic dysplasia presenting punctata. A rare X-linked skeletal dysplasia presenting as piriform aperture stenosis and caused by a novel mutation in the arylsulfatase E (ARSE) gene, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 74.

 

Chung B.H.Y. and Wong V.C.N., Clinical markers that enchance etiologic yield in global developmental delay (GDD) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y. and Wong V.C.N., Clinical markers that enhance etiologic yield in global developmental delay, Pediatrics. 2008, 121: S145-S146.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK) (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK), The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Highlights from the International Global Developmental Delay Initiative, May 2008: Helping children with delays by reaching a common understanding of what is "Global Developmental Delay" and "why", Video Conference for Global Delay Initiative, Surrey Place Centre, University of Toronto, Canada, 29 May 2008. 2008.

 

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 (Transforming Growth Factor-Beta Receptor 2) mutations in Chinese with Marfan syndrome (MFS) and related phenotypes using denaturing high performance liquid chromatography (DHPLC) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 mutations in Chinese with marfan syndrome (MFS) and related phenotypes using DHPLC, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel transforming growth factor2 receptor 2 mutations in Chinese patients with marfan syndrome, Pediatrics. 2008, 121: s116.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LC1) in Hong Kong: comparison with USA, 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 135.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LCI) in Hong Kong: Comparison with USA (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilic factors do not increase central venous catheter blockage in Chinese children with malignancy, Pediatr Blood & Cancer (Epub June 2008). 2008.

 

Chung B.H.Y., Local Organizing Committee Member, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 2008.

 

Chung B.H.Y. and Chitayat D., Renal dysplasia - coarctation of aorta. A new association/syndrome: a report of 6 cases, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 53.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., [Letters to the Editor] Neurologic complications in children hospitalized with influenza: Comparison between USA and Hong Kong, Journal of Pediatrics. 2007, 151(5): e17-e18.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y. and Lau Y.L., Teaching and Learning Medical Genetics - Evaluation of an Interactive Genetics Workshop for Pediatric Clerkship Students, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 103.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y., Yang W. and Lau Y.L., Teaching and Learning Medical Genetics – An Interactive Genetics Workshop for Pediatric Clerkship Students , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Luk H.M., Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurological complications in hospitalized children with laboratory confirmed influenza in Hong Kong: comparison with USA, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Researcher : Fok SFS

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Researcher : Fung CW

List of Research Outputs

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Fung C.W., Blau N., Siu S., Mak C., Tam S. and Wong V.C.N., A new presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency - Dopa Responsive Dystonia (DRD), Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A new presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency Dopa Responsive Dystonia (DRD), 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C., Poon G.W.K., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly - transaldolase deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A rare presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency - Dopa Responsive Dystronia (DRD), A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Cheung P.T., Mak C.M., Siu S., Tam S. and Wong V.C.N., A study of cerebrospinal fluid neurotransmitters assay in children with undiagnosed neurological diseases in Hong Kong, Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society and HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September 2007.

 

Luk H.M., Fung C.W., Mak C.M., Lam C.W., Tam S. and Wong V.C.N., Severe myoclonic epilepsy in infancy (SMEI) or Dravet Syndrome - case report with SCN1A mutation in Hong Kong, 7th Asian Oceanian Epilepsy Congress in Xiamen, China, 15-18 May 2008.

 

Luk H.M., Fung C.W., Mak C.M., Lam C.W., Tam S. and Wong V.C.N., Severe myoclonic epilepsy in infancy (SMEI) or Dravet Syndrome - case report with SCN1A mutation in Hong Kong, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Yam W.K.L., Ronen G.M., Cherk S.W.W., Rosenbaum P., Chan K.Y., Streiner D.L., Cheng S.W.W., Fung C.W., Ho J.C.S., Kwong K.L., Ma L.C.K., Ma D.K.H., Tsui K.W., Wong V.C.N. and Wong T.Y.L., Health-related quality of life of children with epilepsy in Hong Kong: How does it compare with that of youth with epilepsy in Canada?, Epilepsy & Behavior. 2008, 12: 419-426.

 

Yung A.W.Y., Fung C.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Fung KL

List of Research Outputs

 

Fung K.L., Li J., Liang R.H.S. and Chan G.C.F., The Effect of Microtubule-targeting Chemotherapeutic Agents on the Surival of Bone-marrow Derived Mesenchymal Stem Cell, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Ha SY

List of Research Outputs

 

Au W.Y., Lam W.W., Chu W.W., Tam S., Wong W.K., Liang R.H.S. and Ha S.Y., A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major, Haematologica. 2008, 93(1): 116-119.

 

Au W.Y., Lam W.W., Chu W.W., Yuen H.L., Ling A.S., Li R.C., Chan H.M., Lee H.K., Law M.F., Liu H.S., Liang R.H.S. and Ha S.Y., A cross-sectional magnetic resonance imaging assessment of organ specific hemosiderosis in 180 thalassemia major patients in Hong Kong, Haematologica. 2008, 93(5): 784-786.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., Epidemiology & treatment outcome of childhood ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group. , Neurooncol 2008. 2008, 10(3):413.

 

Chan G.C.F., Shing M.M.K., Luk C.W., Li R.C.H., Ling S.C., Li C.K. and Ha S.Y., Characteristis & Outcome of Early Stage Neuroblastoma Treated with Surgery Alone or Low Intensity Chemotherapy, Advances in Neuroblastoma Research 2008, Chiba, Japan, 21-24 May 2008. 176.

 

Chan G.C.F., Chan S.H.S., Ho P.L., Wang L. and Ha S.Y., Effects of Different Forms of Iron Chelators on Bacteria Commonly found in Asian Children, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 36.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., Epidemiology & Treatment Outcome of Childhood Ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group., 13th International Symposium on Pediatric Neuro-Oncology (ISPNO 2008), Chicago, Illnois, USA, June 29-July 2, 2008.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Ha S.Y. and Li C.K., Epidemiology & treatment outcome of childhood ependymoma in Hong Kong: Report from the Hong Kong Pediatric Hematology Oncology Study Group, 13th International Symposium on Pediatric Neuro-Oncology. Chicago, USA, June 29-June 2, 2008.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Li R.C.H., Ling S.C., Ha S.Y., Li C.K., Luk C.W., Lee A.C.W. and Li C.K., Review on childhood astrocytoma: The Hong Kong Paediatric Haematology / Oncology Study Group (HKPHOSG) Experience (1994 to 2006), 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 72.

 

Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Li C.K., Luk C.W., Ha S.Y. and Li C.K., The epidermiology and outcome of childhood brain tumour in Hong Kong: Report from the Hong Kong Paediatric Haematology Oncology Study Group, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 14.

 

Chan G.C.F., Shing M.M.K., Luk C.W., Li R.C.H., Ling S.C., Li C.K. and Ha S.Y., Treatment outcome of neuroblastoma: The Hong Kong experience, 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港. 28 June 2008, 2008.

 

Cheuk D.K.L., Lee T.L., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Chiang A.K.S., Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children, Journal of neurooncology. 2008, 86: 337-347.

 

Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46.

 

Cheuk D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid acinic cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer. 2008 ;50(3):636-9. 2008, 50(3): 636-9.

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Cheung Y.F., Liang X., Chan G.C.F., Wong S.J. and Ha S.Y., Diastolic Myocardial Deformation is Associated with Myocardial Iron Load in Patients with Beta-Thalassaemia Major: A Speckle Tracking Echocardiographic Study, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasiorx (ICL670) on Arterial Function in Patients with Beta-Thalassaemia Major, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 105.

 

Cheung Y.F., Chan G.C.F. and Ha S.Y., Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major, British Journal of Haematology. 2008, 141: 728-733.

 

Chow K.C., Chan G.C.F., Khong P.L., Shek T.W.H., Ha S.Y. and Lau Y.L., Primary Ki-1-positive anaplastic large cell lymphoma of the bone presented with spinal cord compression, Hong Kong Journal of Paediatrics. 2007, 12: 283-286.

 

Gibney G.T., Panhuysen C.I.M., So J.C.C., Ma E.S.K., Ha S.Y., Li C.K., Lee A.C.W., Li C.K., Yuen H.L., Lau Y.L., Johnson D.M., Farrell J.J., Bisbee A.B., Farrer L.A., Steinberg M.H., Chan L.C. and Chui D.H.K., Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong., Am J Hematol. 2008, 458-464.

 

Ha S.Y., Cheuk D.K.L., Ho M.H.K., Chiang A.K.S. and Chan G.C.F., Experience in Chelation Regimens adjusted According To Categorisation of Trancfusing-Dependent Thalassemic Patients Using Serium Ferritin and MRI Data, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 42.

 

Ha S.Y., The dilemma: transplantation versus transfusion and chelation, International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 2007-11-26.

 

Ha S.Y., Li C.K., Yuen H.L., Lee C.H. and Ling S.C., 兒童急性骨髓性白血病治療方案的治療結果, 第十三屆全國小兒血液病學術會議, 湖南宜昌, 中國, 8-11 November 2007, 2007-11-11, 2007, 81-82.

 

Kwok M.K., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Is there a different pattern of second neoplasms among Chinese childhood cancer survivors?, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 39.

 

Lam D.S.T., Khong P.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Reversible encephalopathy induced by systemic high dose methotrexate, Hong Kong Journal of Paediatrics (new series). 2007, 12: 287-292.

 

Lam W.W., Au W.Y., Chu W.C., Tam S., Ha S.Y. and Pennell D.J., One-stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients, Journal of Magnetic Resonance Imaging. 2008, 28(1): 29-33.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Yuan X.J., Chan G.C.F., Chan S.K., Shek T.W.H., Kwong D.L.W., Wei W.I., Ha S.Y. and Chiang A.K.S., Treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children, Hong Kong Medical Journal. 2008, 14(2): 116-123.

 

Researcher : Ho MHK

List of Research Outputs

 

Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46.

 

Dong J., Lee T.L., Lee P.P.W., Ho M.H.K., Wong W.H.S. and Lau Y.L., Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 143.

 

Ha S.Y., Cheuk D.K.L., Ho M.H.K., Chiang A.K.S. and Chan G.C.F., Experience in Chelation Regimens adjusted According To Categorisation of Trancfusing-Dependent Thalassemic Patients Using Serium Ferritin and MRI Data, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 42.

 

Ho M.H.K., Wong W.H.S., Heine R.G., Hosking C.S., Hill D.J. and Allen K.J., Early clinical predictors of remission of peanut allergy in children, Journal of Allergy Clinical Immunology. 2008, 121: 731-736.

 

Ho M.H.K., Tung Y.L., Lee T.L., Tsoi N.S. and Lau Y.L., Letter to the Editor: Anaphylaxis to Paracetamol, Journal of Paediatrics and Child Health. 2008, 44: 746-753.

 

Ho M.H.K., Wong W.H.S., Heine R.G., Hosking C.S., Hill D.J. and Allen K.J., Reply - How predictive are predictors of remission of peanut allergy?, Journal of Allergy Clinical Immunology. 2008, 121(6): 1517-1518.

 

Ho M.H.K., Chan E.Y.T., Lee T.L. and Lau Y.L., The application of allergy tests in childhood allergy, Hong Kong Journal of Dermatology Venerology. 2008, 16: 77-91.

 

Lau Y.L., Dong J., Lee T.L., Lee P.P.W., Ho M.H.K. and Wong W.H.S., Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus, Pediatrics. 2008, 121: S161-2.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 142.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus: A close link with long-term disease damage, Pediatrics. 2008, 121 (Suppl 2): S162.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 34.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 115.

 

Lee T.L., Ho M.H.K., Lee P.P.W. and Lau Y.L., Thalidomide is a Promising DMARD in Achieving Remission Among Children with Refractory Enthesitis-Related Juvenile Idiopathic Arthritis (ERA), The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 81.

 

Researcher : Hui KF

List of Research Outputs

 

Hui K.F., To K.W. and Chiang A.K.S., The Effect of Histone Deacetylase Inhibitors on Lytic Cycle Activation of Epstein-Barr Virus (EBV) in EBV-associated Malignancy, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Hui LH

List of Research Outputs

 

Wong V.C.N. and Hui L.H., Brief Report: emerging services for children with autism spectrum disorders in Hong Kong (1960-2004), Journal of Autism and Developmental Disorders. 2008, 38: 383-389.

 

Wong V.C.N. and Hui L.H., Epidemiological study of autism spectrum disorder in China, Journal of Child Neurology. 2008, 23(1): 67-72.

 

Researcher : Ip EWK

List of Research Outputs

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Researcher : Karlberg JPE

Project Title:

Long-term health consequences of insults in early life

Investigator(s):

Karlberg JPE, Low LCK

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Health Services Research Fund - Full Grants

Start Date:

11/1995

 

Abstract:

To understand the impact of early insults for health in adult-hood.

 

 

Researcher : Koo SD

List of Research Outputs

 

Koo S.D., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Cardiovascular symptoms and signs in evaluating cardiac murmurs in children, Pediatrics International. 2008, 50: 145-149.

 

Researcher : Lam BCC

List of Research Outputs

 

Low L.C.K., Wong W.H.S., Lam B.C.C., Sheng H.P. and Wong W., Role of nutritional intake and total energy expenditure on growth of babies born with intrauterine growth retardation, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 59.

 

Ting J.Y., Lam B.C.C., Wong K.Y., Wong R.M.S. and Wong M.S.C., Changes in Mortality, Morbidity and Early Neurodevelopmental Outcomes Among Extremely-Low-Birth-Weight (ELBW) Infants Born in a Tertiary Perinatal Centre in Hong Kong, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 118.

 

Researcher : Lau ASY

Project Title:

Mechanism of SARS-coronavirus pathogenesis - identification of viral genes implicated in immune dysregulation

Investigator(s):

Lau ASY, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

VCO SARS Research Fund

Start Date:

07/2003

 

Abstract:

To investigate the pathogenesis of SARS-Coronavirus-induced pulmonary injury and multi-organ dysfunctions in humans: (a) to identify the viral determinants of proinflammatory cytokine induction: candidate envelope genes to be examined include Spike (S), Envelope (E) and Membrane (M); (b) to investigate the signaling pathways including kinases and transcription factors involved in the cytokine induction.

 

Project Title:

A role for apoptogenic gene PKR in regulating TNF and cytokine expression in Avian influenza H5N1 infections

Investigator(s):

Lau ASY, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

 

Abstract:

To investigate whether H5N1/97 is a potent inducer of specific signaling kinases, compared to H1N1 or H3N2, leading to enhanced cytotoxicity in the host cell; to investigate whether H5N1/97 induction of TNF-[alpha] and related proinflammatory cytokines is dependent on the expression of these signaling kinases; the mechanism of H5N1/97-induced TNF-[alpha] and related cytokine expression; to identify transcription factors (TF) operative in H5N1-induced and kinase-mediated pathways; the role of these signaling kinases in H5N1/97-induced cytotoxicity: to identify kinase-regulated downstream pathways and induction of apoptogenic genes.

 

Project Title:

Immune dysregulation in HIV infection - mechanism of mycobacterial pathogenesis

Investigator(s):

Lau ASY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To confirm the role of HIV tat on monocytic cells in TH2 cytokine induction and TH1 reponse suppression; to identify the signaling pathways and transcription factors operative in Tat activation of IL-10 promoter; to investigate the effects of BCG or mycobacterial cell wall submits on IL-10 induction; to examine whether Tat interacts with TLR-associated kinases and factors directly or via PKR; to delineate whether exogenous IFN-[gamma] and other TH1 cytokines can counteract the effects of Tat and MTB in IL-10 induction.

 

Project Title:

Immunotherapy of mycobacterial infections: a cell and molecular model

Investigator(s):

Lau ASY, Lee DCW

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

02/2005

 

Abstract:

To examine the profile of cytokine expression including proinflammatory cytokines and anti-inflammatory cytokines in BCG and mycobacterial cell wall subunits-treated cells; to confirm the role of PKR and related kinases in signaling pathways operative in the BCG- and cell wall subunit-induced cytokine expression; to examine the role of IL-10 in inhibition of IFN signaling and macrophage functions; to examine whether IL-10 induces the expression of SOCS to inhibit IFN-gamma signaling; to delineate whether exogenous IFN-gamma and other TH1 cytokines can modulate and reverse the effects of BCG and IL-10 in SOCS induction and restore the effects of IFN-gamma macrophage function.

 

Project Title:

Cytokine Dysregulation and Virus-Induced Cell Death in Avian Influenza Virus Infections

Investigator(s):

Lau ASY, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

Objectives: In this project, we will use H9N2 as prototypes to examine the cellular effects of TNF and IFN induction by avian influenza viruses. We will delineate whether there is differential induction of cytotoxicity by the avian viruses from the human ones. We will also examine the consequences of simultaneous induction of TNF and IFN on cell survival and expression of apoptotic genes. Our Specific Aims are 1) We will delineate whether there is a differential induction of cytotoxicity by the avian viruses (H9N2) compared to the human ones (H1N1 or H3N2). 2) We will examine the consequences of simultaneous induction of TNF and IFN on cell survival and expression of apoptotic genes. Background Influenza A virus infects a wide range of species, including poultry, swine, horses, seals and humans. Of the 15 hemagglutinins (HA) subtypes of influenza A, only H1, H2 and H3 had been known to cause significant morbidity and mortality in humans (1-3). The 1997 outbreak of avian influenza H5N1/97 in Hong Kong was the first documented cases of primary pneumonia rapidly progressing to adult respiratory distress syndrome and multiple organ dysfunctions in humans. In light of the high mortality of H5N1/97 infection, it would be desirable to understand the pathogenesis in order to enhance the development of novel therapy. Influenza A viruses are known to replicate in epithelial cells and leukocytes, resulting in induction of cytokines(4). During influenza virus infection, a multiple array of cytokines, including chemokines (Rantes, MIP-1), and interferons (IFN-α and –β), is induced (5,6). The biological actions of IFNs are mediated by multiple pathways resulting in mRNA degradation by ribonuclease L and inhibition of translation by a dsRNA-activated kinase, PKR. PKR is inducible by IFN, TNF-α, and dsRNA [viral RNA analogue] (7,8). We have previously shown that PKR mediates the cytotoxicity of TNF-α in cells of diverse tissue origins including fibroblasts and monocytes (9). It has been proposed that PKR serves as a common pattern-recognition molecule responsible for mediating these virus-induced antiviral effects (8-11). We previously demonstrated PKR serves multiple roles in the cell including the mediation of TNF-induced cytotoxicity, and induction of apoptotic gene p53 and IFN expression (9, 12-16). The signal transduction role of PKR is further confirmed by its effects on the induction of Fas and NF-kB, following TNF-α or endotoxin treatment. TNF-α is a potent, cytotoxic molecule induced in response to invasion by infectious pathogens or cancer cells. Elevated levels of TNF-α in the serum have been correlated to and predictive of morbidity and mortality in patients with meningococcemia. To unravel the pathogenesis of fulminant H5N1/97 disease in humans, we have developed a H5N1/97-blood macrophage (BMac) model to examine the interactions of H5N1/97-encoded genes and cellular factors which may result in immune dysregulation (17: Peiris as PI and Lau as co-I). Using our model, we have previously demonstrated that H5N1/97 induced dramatically higher levels of cytokine expression when compared to those elicited by “conventional” human H1N1 or H3N2 viruses (17). TNF-α protein levels in H5N1/97-infected macrophage culture supernatants were comparable to those induced by stimulation with E. coli endotoxin, and much higher than those in H1N1 or H3N2 infections (17). Recently, we further demonstrated that the TNF induction and its cytotoxicity are mediated, at least in part, by mitogen-activated protein (MAP) kinases including p38 and ERK (18: J Virol 2005, accepted May 2005, Lau as PI). Induction of proinflammatory cytokines is a major defense mechanism of the host to mobilize the immune system and to combat the invading pathogen. We hypothesize the high mortality associated with H5N1/97 infections may be due to an uncontrolled induction of IFN and TNF, consequent to virus interactions with cellular signaling pathways, leading to dysregulated immune response and differential effects on cell death.

 

Project Title:

Mechanisms of inteferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections

Investigator(s):

Lau ASY, Lee DCW

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

10/2006

 

Abstract:

To examine the signaling pathways in IFN-beta super-induction by avian influenza viruses including H5N1/97, as compared to human viruses including H1N1; to investigate whether there is a preferential activation of IFN regulatory factors (IRFs) during IFN induction in avian virus infections; to determine the transcriptional activation of IFNs by electrophorectic mobility shift, IFN promoter-driven luciferase and steady-state quantitative-PCR assays, in addition to Western blots; to delineate whether there is differential induction of cytotoxicity and apoptotic genes by the avian viruses from the human ones.

 

Project Title:

HIV dysregulation of the toll-like receptor system - implications for pathogenesis

Investigator(s):

Lau ASY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

To investigate the effects of Tat on the expression of TLR2 in primary blood monocytes and identify whether there are other TLRs inducible by Tat; to identify the kinases and signaling pathways operative in Tat induction of TLR2 and its related receptors; to investigate whether the enhanced TLR plays a role in infection by HSV and the level of viral replication in monocytes; to examine the effects of Tat on astrocytic cells including TLR expression and infection by HSV.

 

Project Title:

Regulation of Matrix Metalloproteinases by Epstein-Barr Virus Latent Membrane Protein 1

Investigator(s):

Lau ASY, Chua DTT, Lee DCW

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Objectives: In this project, we will investigate the role of Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) in the expression of Matrix Metalloproteinases (MMPs) and their consequent effects on cell migration. Our Specific Aims are: 1) We will generate LMP1-expressing cells including fibroblasts or epithelial cells by transient transfection of the cells with LMP1 cDNA. 2) We will delineate the mechanisms of Epstein-Barr Virus, specifically LMP1 gene, in the regulation of MMPs induction and the promotion of cell invasion. Background Epstein-Barr Virus (EBV) is a human herpesvirus that infects a large percentage of the world’s population (1). EBV has been known to be highly associated with human malignancies, including Burkitt’s lymphoma, post-transplant lymphomas, AIDS-associated lymphoma, gastric carcinoma, and the highly invasive nasopharyngeal carcinoma (NPC), putatively related to and as a consequence of the latent infection state (1,2). Specific EBV latent genes including LMP1, 2A, and 2B, as well as EBV nuclear antigen-1 (EBNA1) and EBV non-polyadenylated RNAs (EBER) are expressed in NPC cells (1). LMP1 has been shown to have transforming properties in mouse fibroblasts (3). It also plays an important role in EBV-induced B-cell immortalization and association with metastasis in nasopharyngeal carcinoma (3, 4). In in vitro study, LMP1 regulates Matrix Metalloproteinase 1 (MMP1) expression in epithelial cells, as well as MMP2 and -9 in B-cells. The transmembrane component of the LMP1 C-terminal contains two important signaling domains, namely CTAR1 and CTAR2. The interactions of CTAR domains with TRAFs or TRADD result in the activation of NF-kB, p38 MAPK, JNK and/or JAK/STAT signaling pathways (5). Matrix Metalloproteinase, with a total of 23 family members, are endopeptidases involved in the degradation of extracellular matrix proteins and their upregulation in cancer samples implicates their role in tumor metastasis (6). Selected MMPs are highly expressed in malignant cancers, in particular in the areas of active invasion such as the interface of tumor and stroma. For example, MMP-3 induced by cytokines and cellular factors in cancer and non-cancerous stromal cells may result in the deregulation of E-cadherin, a prototype adhesion molecule in maintaining the intercellular matrix (3). Thus destruction of E-cadherin and associated proteins promotes tumor invasion. Our previous studies indicate that LMP1 regulates the expression of proinflammatory cytokines including TNF and IL-6 as well as anti-inflammatory cytokines including IL-10. In light of the role of LMP1 in cytokine regulation and the fact that MMPs are regulated by TNF, we hypothesize that LMP1 promotes the progression and metastasis of highly invasive NPC via the induction of MMPs.

 

List of Research Outputs

 

Chan M.M., Cheung B.K.W., Li J.C. and Lau A.S.Y., Inhibition of Mycobacteria-induced IL-10 Expression by Exogenous Th-1 Cytokines, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007. 2007-12-14.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Interaction of IL-10 and Th1 Cytokines in Mycobacterial Evasion of Immunity, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of BCG-induced immune responses, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), 16-19 September 2007, Oxford, England. 2007.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of Mycobacteria-induced Immune Evasion: IFNg and IL-12 Suppression of BCG-induced IL-10 Expression, International Society for Interferon and Cytokine Research 2007 (abstract published in the “Journal of Intrerferon & Cytokine Research” Vol 27 No. 8 August 2007), Oxford, UK. 2007.

 

Cheng M., Xing B., Li C.B., Cheung B.K.W. and Lau A.S.Y., Interferon-gamma regulation of TNF-alpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells., Internatl J Cancer. 2007, 121: 1190-6.

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J., Lau A.S.Y. and Yang M., Effects of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes. , Blood 2007. 2007, 118(11):628a.

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Cheung B.K.W. and Lau A.S.Y., Mycobacterial Evasion of Immunity Via Cytokine Dysregulation: A Potential Role for Mitogen-Activated Protein Kinase Phosphatase-1, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, Hong Kong, 15 March. 2008.

 

Cheung B.K.W. and Lau A.S.Y., Mycobacterial evasion of immunity via cytokine dysregulation: a potential role for mitogen-activated protein kinase phosphatase-1, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Lau A.S.Y., A Novel and Scientific Approach to Study TCM: Application of Cell Signaling and Genomics, Hong Kong Scientific Park Conference hosted by Science Park & HKU, HK, 30 May 2008. 2008.

 

Lau A.S.Y., Application of genomics and cell signaling technologies to investigate traditional Chinese machine: Panex Ginseng and its immunomodulatory effects, University of Turku, Naantali, Finland, November 6-7. 2007.

 

Lau A.S.Y., As invited speaker, HKU TCM Workship 2007, 14 December 2007.

 

Lau A.S.Y., Biological Effects of TCM and Cell signaling, NHC Conference, Turku, Finland, November 8-9. 2007.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Dysregulation of the Interferon-gamma Signal Transduction: Suppression of Jak/STAT Pathways and Implication for Opportunistic Infections, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 101.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Tat protein inhibits interferon-gamma signaling by suppressing STAT 1 activation: implications for AIDS pathogenesis and opportunistic infections, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Oxford, England, September 16-19. 2007.

 

Lau A.S.Y., HIV induced immune dysregulation, Hosted by Prof David Speert, Division of Infectious Disease and Immunology, BC Children Hospital Research Institute, University of British Columbia, Canada, September 5. 2007.

 

Lau A.S.Y., Immunomodulation and biological properties of herbal and natural products, Turku Health Conference, Finland, November 8-9. 2007.

 

Lau A.S.Y., Internal Reviewer, RGC CERG 2008-09. 2007.

 

Lau A.S.Y., Mechanism of actions of TCM, International Consortium for the Globalization of Chinese Medicine Annual Convention, Beijing, PR China, August 30. 2007.

 

Lau A.S.Y., Mechanisms for microbial evasion of immunity, Frontiers in Biomedical Research, HKU 2008, 12 December 2008. 2008-12-12.

 

Lau A.S.Y., Moderator on Data Management (collection, correction, storage, disclosure, non-disclosure, ownership, sharing, etc), The Second Case-based Workshop on Research Integrity, LKS Faculty of Medicine, The University of Hong Kong, 27 June. 2008.

 

Lau A.S.Y., Natural products and herbal medicine on cytokine modulations, Visiting Professor for graduate students, University of Turku, November 6-7. 2007.

 

Lau A.S.Y., Scientific basis of TCM Research, University of Turku, Naantali, Finland, November 6-7. 2007.

 

Lau A.S.Y., Traditional Chinese Medicine Workshop, University of Hong Kong, Hong Kong, 14 December. 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H. and Lau A.S.Y., Application of Genomics and cell signaling technologies to investigate traditional Chinese medicine: Panex Ginseng and its immunomodulatory effects, NHClaims 2007 Congress, Naantali, Finland, November 7-9. 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H., Rong J., Tam P.K.H. and Lau A.S.Y., Application of Platform Technologies to Investigate the Immunomodulatory Effects of Ginseng, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Tam P.K.H. and Lau A.S.Y., Application of platform technologies to investigate the immunomodulatory effects of Ginseng, 4th International Think Tank Forum, Faculty of Medicine, The University of Hong Kong, November 14-16. 2007.

 

Lee D.C.W., Chua D.T.T., Wei W.I., Sham J.S.T. and Lau A.S.Y., Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from Nasopharyngeal carcinoma, Biomedicine & Pharmacotherapy. 2007, 61: 520-526.

 

Lee D.C.W., Mok K.P., Law H.Y., Tam H.M., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of interferon dysregulation and virus-induced cell death in Avian-Influenza H5N1 infections, Health Research Symposium 2007: Building bridges between research, practice & policy, September 29,. 2007.

 

Li C.B., Yim H.C.H., Lee D.C.W. and Lau A.S.Y., Best Abstract Award at the Annual Scientific Meeting and General Meeting 2008, Hong Kong Society for Immunology. 2008.

 

Li C.B., Yim H.C.H. and Lau A.S.Y., Cellualr Signaling Events In Cytokines And Sulphamethoxasole Interactions, The First Scientific Meeting And The Second Annual General Meeting, The Hong Kong Society For Paediatric Immunology And Infectious Diseases . 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, Annual Scientific Meeting and General Meeting of Hong Kong Society for Immunology 2008 . 2008.

 

Li C.B., Yim H.C.H. and Lau A.S.Y., Runner-up Oral Presentation Award At The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases, The Hong Kong Society For Paediatric Immunology And Infectious Diseases. 2008.

 

Liu C., Chan L.K.Y., Chik S.C.C. and Lau A.S.Y., Identification of multiple markers for phylogenetic and DNA barcoding studies for medicinal plants, The Second International Barcode Conference. 2007.

 

Rong J., Cheung Y.H., Lau A.S.Y., Shen J., Cheng Y.C. and Tam P.K.H., Induction of heme oxygenase-1 by the Chinese herbal formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Rong J., Cheung Y.H., Lau A.S.Y., Shen J., Tam P.K.H. and Cheng Y.C., Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, Int J Mol Med. Athens, Greece, D.A. Spandidos, 2008, 21: 405-11.

 

Rong J., Cheung Y.H., Lau A.S.Y., Cheng Y.C. and Tam P.K.H., Regulation of Heme Oxygenase-1 Expression by Traditional Chinese Medicines: Molecular Analysis of Traditional Remedy, NUTRISCIENCES AND HEALTH 2007: bioprospecting for neuroprotectants. Prince Edward Island, Canada, 2007.

 

Shen J., Rong J., So K.F., Lau A.S.Y. and Tam P.K.H., Integration of multiple comprehensive approaches for exploration of therapeutic principle of BHD-01 in post-stroke treatment, HKU TCM Workshop 2007.

 

Shen J., Rong J., Tong Y., So K.F., Lau A.S.Y., Liu K.J., Tam P.K.H. and Cheng Y.C., Integration of systemic biology, chemical profile fingerprint and functional imaging technology for understanding therapeutic principle of Chinese medicinal formula: a study on classical Post-Stroke Formula, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Sze C.W., Zhang Y., Zhang Z., Lau A.S.Y. and Tong Y., Erxian decoction stimulates estrogen secretion via steroidogenic signalling transduction pathway in vivo, 3rd International Congress on Complementary Medicine Research, Sydney, Australia, 29-31 March 2008 (Poster Abstract, p120). 2008, 60.

 

Tam H.M., Lee D.C.W. and Lau A.S.Y., Molecular Mechanisms of the Hyper-induction of TNF-a by Avian Influenza in Human Macrophages, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Best Oral Presentation Award, The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases, The Hong Kong Society For Paediatric Immunology And Infectious Diseases. 2008.. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Cellular signaling events in cytokines and sulphamethoxasole interactions, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 Tat Plays a Role in Dysregulating Lipopolysaccharide-Induced Cytokine Expression: Implications for Immune Defects in Aids, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 15 March. 2008.

 

Yim H.C.H., Li C.B., Lau A.S.Y. and Lee D.C.W., HIV-1 Tat plays a role in dysregulating lipopolysaccharide-induced cytokine expression: implications for immune defects in AIDS, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune response induced by lipopolysaccharides, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune responses induced by lipopolysaccharides, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Researcher : Lau YL

Project Title:

A community-based educational program on thalassaemias to enhance awareness with the aim to reduce burden of thalassaemia related health problems in Hong Kong

Investigator(s):

Lau YL, Ha SY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Health Promotion Projects

Start Date:

09/1997

 

Abstract:

To enhance the awareness of the community regarding thalassaemias; to counsel, screen and/or refer clinets who come forward to the Unit after the educational sessions; to decrease the disease burden of thalassaemias in Hong Kong as well as to serve as a possible model for southern China.

 

Project Title:

Comparison of process upgrade varicella vaccine (Puvv) with VARILRIX-TM

Investigator(s):

Lau YL

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

07/1999

 

Abstract:

To evaluate and provide information on the safety, tolerability, and immunogenicity of the Process Upgrade Varicella Vaccine (PUVV) at ~16,000 or ~50,000 PFU/0.5ml compared to VARILRIX ( estimated at a release dosage of ~50,000PFU/dose) when they are concomitantly with MMRII at separate injection sites.

 

Project Title:

Seroepidemiological prevalence survey of SARS-associated coronavirus antibody in children residing in Amoy Garden compared to a control group in southern district

Investigator(s):

Lau YL, Peiris JSM, Chiu SSS, Lam TH

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Health and Health Services Research Fund - Full Grants

Start Date:

05/2004

 

Abstract:

To define the seropositive rate of SARS-associated coronavirus (CV) infection among children who are household contacts or community contacts of SARS cases; to ascertain the full clinical spectrum of SARS-associated CV infection among chldren in Amoy Garden.

 

Project Title:

Joint Course on Molecular Medicine under the Joint Centre for Advanced Study

Investigator(s):

Lau YL

Department:

Medical Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

07/2005

 

Abstract:

To carry out a joint course on molecular medicine under the Joint Centre for Advanced Study.

 

Project Title:

The role of dentritic cells in SARS coronavirus infection

Investigator(s):

Lau YL, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

08/2005

 

Abstract:

Despite the SARS epidemic being controlled by case isolation, neither an effective treatment nor an efficacious vaccine is available. Our study will shed lights on the pathogenesis and the immune evasion of SARS-CoV and the knowledge gained may facilitate the development of new treatment protocols and vaccines for SARS.

 

Project Title:

Immune response of cord blood macrophages and dendritic cells to the 1997 and 2004 strains of avian influenza viruses

Investigator(s):

Lau YL, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2005

 

Abstract:

(1) To determine the host response against human/avian viruses infection. In particular, we will focus on: host immune responses; mechanism of lymphopenia;evolution of H5N1; (2) to campare the cytokine/chemokine expression in antigen presenting cell infected by different influenza viruses; (3) to determine the expression of death receptor ligands in influenza infected APCs and subsequent effect on T cell priming and polarisation.

 

Project Title:

Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS

Investigator(s):

Lau YL, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

09/2005

 

Abstract:

To test the association of single nucleotide polymorphisms (SNPs) and microsatellites of 6 cytokine and chemokine genes, i.e. interferon-gamma (IFN-gamma), interluekin-12 (IL-12), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and interferon gamma-induced protein-10 (IP-10) with susceptibility to SARS; To test the association of these SNPs and microsatellites with mortality from SARS.

 

Project Title:

p21 gene polymorphism with systemic lupus erythematosus and rheumatoid arthritis

Investigator(s):

Lau YL, Lau WCS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Systemic lupus erythematosus (SLE ) is a complex, multifactorial autoimmune disease that is characterized by the production of various autoantibodies. Dysregulated T cell-dependent induction of autoreactive B cells is considered to play a critical role in the development of SLE (1). The etiology and pathogenesis of SLE remain unclear, but the increased concordance rate in monozygotic twins, familial aggregation and high heritability suggested that the genetic factor is involved in the development of SLE (2-4). Cyclin-dependent kinase inhibitor 1A (also known as p21, WAF1 or CDKN1A) is a negative regulator of cyclin dependent kinases (CDKs) (5). The p21 protein encodes a 21 kDa cell cycle regulatory protein that forms quaternary complexes with the entire cyclin/CDK holoenzyme and acts as pancyclin inhibitors (6). It interacts with CDK2, CDK3, CDK4 and CDK6, thereby inhibiting the progression from the G1 to the S phase of the cell cycle (7-9). It can also bind to the replication factor proliferating cell nuclear antigen (PCNA) and inhibit DNA replication (10). The p21 gene contains the p53 binding site that is localized at 2.4 kb upstream from the translational start site and expression of p21 gene was found to be inducible by wild-type p53 gene expression (11). Moreover, several growth factors and cytokines, including interferon (IFN)-α and -γ, can modify p21 expression (12,13). As p21 is an important molecule in mediating cell cycle arrest, loss of function in p21 may favor cell proliferation. Mutations in the p21 gene have been reported to associate with development of various cancers (14-17). And cells lacking p21 gene are defective in DNA repair, which might induce impaired regulation in cell proliferation (18). Inactivating mutations of p21 lead to overexpression and hyperactivation of low-avidity, autoreactive T cells that are found in abundance in the peripheral lymphoid organs of normal individuals (19). These findings suggested that dysregulated p21 gene expression might contribute to defective cell cycle regulation and therefore lead to excessive cell proliferation and activation. The human p21 gene maps on chromosome 6p21.2 (11), which is a susceptibility region for SLE (20,21). A significant reduction in p21 gene expression is found in SLE patients as compared to controls (22). A lower expression in SLE patients is detected at various points from the G1 to G2/M phase through the S phase when compared with controls (22). Therefore, malfunction of p21 protein may contribute to the pathogenesis of systemic autoimmunity through a variety of primary or secondary mechanisms. Indeed, the p21-/- female mice with 129/Sv x C57BL/6 mixed backgrounds show development of severe lupus-like diseases followed by early mortality, high levels of anti-dsDNA antibodies and kidney immune complex deposits (23). However, the p21-/- lupus-prone BXSB mice show inhibition for the development of systemic autoimmunity (24). The p21-/- BXSB lupus-prone mice show enhancement of the Fas/FasL-mediated activation-induced T cell death and therefore promote the apoptosis of the accumulated autoreactive T and B cells, which inhibit spontaneous systemic autoimmunity (24). Although the above findings showed conflicting results for p21 deficiency, they suggested p21 gene is involved in the pathogenesis of SLE. Similar to SLE, rheumatoid arthritis (RA) is also a complex autoimmune diseases that involves genetic factors. Although disease pathogenesis remains unclear, we have previously identified the mannose binding lectin (MBL) gene as susceptibility gene in both SLE and RA (25-27) and recently, we have demonstrated that the low producing genotype of IL-10 promoter is associated with disease susceptibility and serositis in Hong Kong Chinese patients with SLE (28). The identification of susceptibility allele in SLE and RA by case-control study offers the potential for early prediction of risk of disease progression. This should also provide an approach to select the most appropriate candidate genes for intervention with new biological agents which may prevent or arrest disease progression in those at highest risk. References: Please refer to attachment [05-CRCG-SLE-References.doc]

 

Project Title:

Association of B Lymphocyte Stimulator (BLyS) gene polymorphisms with systemic lupus erythematosus (SLE)

Investigator(s):

Lau YL, Lau WCS

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Systemic lupus erythematosus (SLE ) is a complex, multifactorial autoimmune disease that is characterized by the production of various autoantibodies. Dysregulated T cell-dependent induction of autoreactive B cells is considered to play a critical role in the development of SLE (1). The etiology and pathogenesis of SLE remain unclear, but the increased concordance rate in monozygotic twins, familial aggregation and high heritability suggested that the genetic factor is involved in the development of SLE (2-4). BLyS (BAFF, TALL-1, THANK, zTNF-4 and TNFSF-13B) (NCBI gene ID: 10673) is one of the proteins controlling B cell homeostasis, tolerance and malignancy (5-8). It is critical for B cell survival and maturation. Excessive BLyS production has been shown to trigger severe autoimmune diseases in mice resembling SLE and Sjögren’s syndrome (SS) (9-12). BLyS is expressed by various types of cells including neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells (FDCs) in germinal centres (GCs), activated T cells, malignant B cells and CD34+ cells from cord blood (13-20). Messenger RNA for BLyS is found in a variety of tissues, and its levels seem to be relatively constant, suggesting that the production rates for BLyS may be quite stable (21). Several pieces of evidence have suggestd that BLyS may be a candidate gene of SLE. BLyS is encoded on human chromosome 13q34 and murine chromosome 8 (5,7,22). As determined by previous genome-wide screening, this region is a susceptible locus of SLE (LOD score = 2.50) (23) Several polymorphisms have been identified in the human BLyS gene (24). These include four single nucleotide polymorphisms (SNPs) in the promoter region, -1283G/A, -871C/T, -514T/C and -353G/C and one SNP in the intron 1, IVS1-45C/G. Transgenic mice overexpressing BLyS have been well-studied (9-11). In general, BLyS overexpression creates a state of immune hyperreactivity that is skewed primarily towards peripheral B cell activation and terminal differentiation, including increased mature B cells in the periphery, enlarged lymphoid organs and spleens, and hypergammaglobulinemia with autoimmune-like manifestations, including anti-DNA antibodies and Ig-deposition in the kidneys leading to glomerulonephritis with proteinuria and decreased lifespan. In addition, a disproportional increase in the MZ B cells, and the presence of rheumatoid factors have been reported (9). Mice models for SLE, which include the NZBWF1 and the Fas-dependent MRL/lpr mice, were found to have elevated levels of circulating BLyS, which increases during disease progression (10, 25). In SLE patients, BLyS level is found to be elevated and fluctuate during the course of SLE (26). Significantly elevated serum BLyS levels correlated with higher levels of anti-dsDNA antibody titers among SLE patients has also been reported (27-28). In addition, the association of SNPs of BLyS, -1283G/A, -871C/, -514T/C, -353G/C and IVS1-45C/G, with SLE and RA has been demonstrated in a case-control study using 156 SLE patients, 221 RA patients and 227 healthy controls (24). It was found that -871TT genotype was over-represented in SLE patients with anti-Sm antibody (P = 0.082) and the -871 T allele was associated with higher BLyS mRNA level (P = 0.010). As pathogenesis of SLE involves the break of tolerance of B cells, whereas BLyS is essential for B cell survival when B cells progress from transient T1 to transitional T2 stages, MZ B cell formation, differentiation of MZ B cells, stable GC formation, proper humoral responses and immunoglobulin switch and T cell response. We hypothesize that BLyS is a candidate gene of SLE and we aimed to identify whether the BLyS gene polymorphisms are associated with SLE and disease phenotypes in our population. We also aimed to investigate the correlation between these BLyS gene polymorphisms and their circulating levels. Reference: Please refer to attachment [06-CRCG-BLyS-Reference.doc]

 

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Chan S.S.C., Leung D., Chui H., Tiwari A.F.Y., Wong E.M.Y., Wong C.N., Barnsteiner J.H. and Lau Y.L., Parental responses to child's isolation during the SARS outbreak, Ambulatory Pediatrics. 2007, 7(5): 401-404.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum polysaccharides can induce human monocytic leukemic cells into dendritic cells with immunotolerogenic function., Blood 2007. 2007, 118(11):4208a.

 

Chan W.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley, International Immunology. England, Oxford University Press, 2007, 19 (7): 891-899.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum Polysaccharides Can Induce Human Monocytic Leukemia Cells into Dendritic Cells with Immunotolerogenic Function, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 301B.

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J.Y., Lau Y.L. and Yang M., Effects of Serotonin on Proplatelet Formation and F-actin Reorganization in Human Megakaryocytes, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 628a.

 

Cheuk D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid acinic cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer. 2008 ;50(3):636-9. 2008, 50(3): 636-9.

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Cheung Y.F., Huang G.Y., Chen S.B., Liu X.Q., Li X., Liang X.C., Huang M.R., Chen S., Huang L.S., Liu X.Q., Chan K.W. and Lau Y.L., Best poster presentation: Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Chiu S.S.S., Ho P.L., Chow K.H., Yuen K.Y. and Lau Y.L., Nasopharyngeal Carriage of Antimicrobial-Resistant Streptococcus pneumoniae among Young Children Attending 79 Kindergartens and Day Care Centers in Hong Kong, Health Research Symposium 2007: Building Bridges between Research, Practice & Policy, 29 September 2007.

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Chow K.C., Chan G.C.F., Khong P.L., Shek T.W.H., Ha S.Y. and Lau Y.L., Primary Ki-1-positive anaplastic large cell lymphoma of the bone presented with spinal cord compression, Hong Kong Journal of Paediatrics. 2007, 12: 283-286.

 

Chu S.F., Tam C.M., Wong W.H.S., Kam K.M., Lau Y.L. and Chiang A.K.S., Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese, Genes and Immunity. Nature, 2007, 8: 475-479.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK) (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK), The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 (Transforming Growth Factor-Beta Receptor 2) mutations in Chinese with Marfan syndrome (MFS) and related phenotypes using denaturing high performance liquid chromatography (DHPLC) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 mutations in Chinese with marfan syndrome (MFS) and related phenotypes using DHPLC, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel transforming growth factor2 receptor 2 mutations in Chinese patients with marfan syndrome, Pediatrics. 2008, 121: s116.

 

Dong J., Lee T.L., Lee P.P.W., Ho M.H.K., Wong W.H.S. and Lau Y.L., Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 143.

 

Gibney G.T., Panhuysen C.I.M., So J.C.C., Ma E.S.K., Ha S.Y., Li C.K., Lee A.C.W., Li C.K., Yuen H.L., Lau Y.L., Johnson D.M., Farrell J.J., Bisbee A.B., Farrer L.A., Steinberg M.H., Chan L.C. and Chui D.H.K., Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong., Am J Hematol. 2008, 458-464.

 

Ho M.H.K., Tung Y.L., Lee T.L., Tsoi N.S. and Lau Y.L., Letter to the Editor: Anaphylaxis to Paracetamol, Journal of Paediatrics and Child Health. 2008, 44: 746-753.

 

Ho M.H.K., Chan E.Y.T., Lee T.L. and Lau Y.L., The application of allergy tests in childhood allergy, Hong Kong Journal of Dermatology Venerology. 2008, 16: 77-91.

 

Ho P.L., Chiu S.S.S., Chow K.H., Mak C.K. and Lau Y.L., Pediatric hospitalization for pneumococcal diseases preventable by 7-valent pneumococcal conjugate vaccine in Hong Kong, Vaccine. 2007, 25: 6837-6841.

 

Kwok M.K., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Is there a different pattern of second neoplasms among Chinese childhood cancer survivors?, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 39.

 

Lam D.S.T., Khong P.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Reversible encephalopathy induced by systemic high dose methotrexate, Hong Kong Journal of Paediatrics (new series). 2007, 12: 287-292.

 

Lau S.K.P., Yip C.Y., Que T.L., Lee R.A., Au-yeung R.K.H., Zhou B., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong, Journal of Infectious Diseases. 2007, 196: 986-993.

 

Lau S.K.P., Yip C.Y., Tsoi H.W., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV associated with acute respiratory illness in children, Journal of Clinical Microbiology. 2007, 45(11): 3655-3664.

 

Lau Y.L., AAP Audio Journal - PREP Audio issue on Emerging and Reemerging Infections, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 2008.

 

Lau Y.L., Approach to diagnosis of primary immunodeficiency disorders, Pediatric Grand Round, University of Minnesota, Minnesota, USA, 7 November 2007. 2007.

 

Lau Y.L., Asking the right question in research, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 2007.

 

Lau Y.L., Chairman, Oral Session on Genetic Diseases, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 2007.

 

Lau Y.L., Chairperson for Breakfasts Session on Immunity and Infectious Diseases, Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, Honolulu, Hawaii, 3-6 May 2008. 2008.

 

Lau Y.L., Chairperson for Neonatal Infectious Diseases & Immunology I, Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, Honolulu, Hawaii, 3-6 May 2008. 2008.

 

Lau Y.L., Chairperson, Research Networks in ASPR, Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, Honolulu, Hawaii, 3-6 May 2008. 2008.

 

Lau Y.L., Chairperson, Bridging the Gap: Global Advances in Pediatric Vaccination, Kuala Lumpur, 20-22 June 2008. 2008.

 

Lau Y.L., Clinical presentations of PID, The First Spring School on Primary Immunodeficiency Chinese PID Summer School, Sanya, PRC, 22-25 February 2008. 2008.

 

Lau Y.L., Emerging respiratory viral pathogens, 13th Annual CME Conference on Emerging Infections in Clinical Practice and Public Health, Minnesota, USA, 8-9 November 2007. 2007.

 

Lau Y.L., Evaluation of humoral immune function in the patient with recurrent infection, 13th International Congress on Infectious Diseases, Kuala Lumpur, 20-22 June 2008.

 

Lau Y.L., Genetic susceptibility to infectious diseases, Chula Medical Expo 2007, Bangkok, Thailand, 15-19 October 2007. 2007.

 

Lau Y.L., Key issues facing academic pediatric departments, International Pediatric Chairs Association Satellite Meeting, Athens, Greece, 25-31 August 2007. 2007-8-31, 2007.

 

Lau Y.L., Moderator: Forum 3, 上海兒童醫院中心十周年慶典, 國際兒童醫院院長高峰會議, 上海, 中國, 30 May 2008, 2008.

 

Lau Y.L., Dong J., Lee T.L., Lee P.P.W., Ho M.H.K. and Wong W.H.S., Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus, Pediatrics. 2008, 121: S161-2.

 

Lau Y.L., Pitfalls in diagnosis of primary immunodeficiencies, Chula Medical Expo 2007, Bangkok, Thailand, 15-19 October 2007. 2007.

 

Lau Y.L., Plenary lecture on Pathogenesis of SARS and HPAI, Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, Honolulu, Hawaii, 3-6 May 2008. 2008.

 

Lau Y.L., Primary Immunodeficiency, 第四屆江、浙、滬兒科學術會會議, Nanjing, PRC, 15-17 November 2007, 2007.

 

Lau Y.L., SARS and avian influenza - What have we learnt?, 第七屆全國小兒免疫學術研討會, Qingdao, PRC, 11-14 October 2007, 2007, 1-2.

 

Lau Y.L., SARS and avian influenza - What have we learnt?, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 2007.

 

Lau Y.L., 原發性免疫缺陷病遺傳診斷網絡, 上海兒童醫院中心十周年慶典, 國際兒童醫院院長高峰會議, 上海, 中國, 30 May 2008, 2008.

 

Law H.K.W., Cheung C.Y., Sia S.F., Chan Y.O., Peiris J.S.M. and Lau Y.L., SARS-coronavirus induced different gene expression of chemokine receptors in human monocyte-derived adult and cord blood dendritic cells, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 103.

 

Law H.K.W., Cheung C.Y., Sia S.F., Chan Y.O., Peiris J.S.M. and Lau Y.L., The role of dendritic cells in SARS coronavirus infection, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 142.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus: A close link with long-term disease damage, Pediatrics. 2008, 121 (Suppl 2): S162.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Lee P.P.W., Jiang L.P., Wang X.C., Chan K.W., Tu W. and Lau Y.L., Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor b1 deficiency, European Journal of Pediatrics. Springer, 2008, 167: 231-232.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 34.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 115.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y. and Lau Y.L., Teaching and Learning Medical Genetics - Evaluation of an Interactive Genetics Workshop for Pediatric Clerkship Students, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 103.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y., Yang W. and Lau Y.L., Teaching and Learning Medical Genetics – An Interactive Genetics Workshop for Pediatric Clerkship Students , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee T.L., Ho M.H.K., Lee P.P.W. and Lau Y.L., Thalidomide is a Promising DMARD in Achieving Remission Among Children with Refractory Enthesitis-Related Juvenile Idiopathic Arthritis (ERA), The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 81.

 

Lin G., Wang Z., Wang L., Lau Y.L. and Yang W., Identification Of Linked Regions Using High-density Snp Genotype Data In Linkage Analysis, Bioinformatics. Oxford press, 2008, 24(1): 86-93.

 

Mak C.M., Lam C.W., Tam S., Lai C.L., Chan L.Y., Fan S.T., Lau Y.L., Lai J.Y., Yuen P., Hui J., Fu C.C., Wong K.S., Mak W.L., Tze K., Tong S.F., Lau A., Leung N., Hui A., Cheung K.M., Ko C.H., Chan Y.K., Ma O., Chau T.N., Chiu A. and Chan Y.W., Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: identification of 17 novel mutations and its genetic heterogeneity, Journal of Human Genetics. 2008, 53(1): 55-63.

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Ng P., Yang W. and Lau Y.L., Systemic Lupus Erythematosus In Hong Kong Chinese, 12th Research Postgraduate Symposium, Hong Kong, 11 Dec, 2007.

 

Siu H.O., Yang W., Lau C.S., Chan T.M., Wong R.W.S., Wong W.H.S. and Lau Y.L., Association of a Haploytpe of IRF5 Gene with Systemic Lupus Erythematosus in Chinese, Journal of Rheumatology. 2008, 35(2): 360-362.

 

Wang M.C., Chan K.W., Wang X.C., Wang Y., Lau Y.L., Shum S.C. and Cheung N.Y., 嚴重聯合免疫缺陷病 I 例基因診斷及家系分析, 第四屆江、浙、滬兒科學術會會議, Nanjing, PRC, 15-17 November 2007, 2007.

 

Willcocks L.C., Lyons P.A., Clatworthy M.R., Robinson J.I., Yang W., Lau Y.L. and Smith K.G.C., 8. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake, Journal of Experimental Medicine. 2008, 10.1084/jem.20072413: 1-9.

 

Yang W., Huang P., Zhao M. and Lau Y.L., Biomarker Identification For Early Tumor Detection Aided By Bioinformatics Gene Expression Analysis, The International Conference On Biomedical Engineering And Informatics (bmei2008), Sanya, Hainan, China. 2008.

 

Yang W., Zhao M. and Lau Y.L., Biomarker Identification for Early Tumor Detection Aided by Bioinformatics Gene Expression Analysis, 2008 International Conference on BioMedical Engineering and Informatics. 2008, 1: 469-473.

 

Yang W., Sham P.C., Wang Z., Wang L., Huang P. and Lau Y.L., Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies , European Journal of Human Genetics. 2008, doi:10.1038/ejhg.2008.116: 1-9.

 

Yang W., Wang Z., Wang L., Huang P. and Lau Y.L., Prediction of the linked regions and exclusion probabilities -- requirement on family sizes in linkage analyses , 57th annual meeting of the american society of human genetics, Oct 23-27, 2007, SanDiego, USA . 2007.

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Yip M.S., Law H.K.W., Tu W. and Lau Y.L., Immune responses of human respiratory epithelia cells to human metapneumovirus and respiratory syncytial virus. IMMUNORIO 2007, 13th International Congress of Immunology, Rio de Janeiro-Brazil, 21-25 August 2007.

 

Researcher : Law HKW

List of Research Outputs

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum polysaccharides can induce human monocytic leukemic cells into dendritic cells with immunotolerogenic function., Blood 2007. 2007, 118(11):4208a.

 

Chan W.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley, International Immunology. England, Oxford University Press, 2007, 19 (7): 891-899.

 

Chan W.K., Cheung C., Law H.K.W., Lau Y.L. and Chan G.C.F., Ganoderma lucidum Polysaccharides Can Induce Human Monocytic Leukemia Cells into Dendritic Cells with Immunotolerogenic Function, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 301B.

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Lam T.H., Yuen K.Y., Ho P.L., Wong K.C., Leong W.M., Law H.K.W., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis, Microbial Pathogenesis. 2008, 45: 12-17.

 

Law H.K.W., English Editor (Senior), The Journal of Clinical Pediatrics. 临床儿科杂志, 2007, July 2006 - Present.

 

Law H.K.W., Cheung C.Y., Sia S.F., Chan Y.O., Peiris J.S.M. and Lau Y.L., SARS-coronavirus induced different gene expression of chemokine receptors in human monocyte-derived adult and cord blood dendritic cells, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 103.

 

Law H.K.W., Cheung C.Y., Sia S.F., Chan Y.O., Peiris J.S.M. and Lau Y.L., The role of dendritic cells in SARS coronavirus infection, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Wong K.C., Leong W.M., Law H.K.W., Ip K.F., Lam T.H., Yuen K.Y., Ho P.L., Tse W.S., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Molecular Characterization of Clinical Isolates of Mycobacterium tuberculosis and Their Association with Phenotypic Virulence in Human Macrophages, In: ASM, Clinical and Vaccine Immunology. ASM, 2007, 14(10).

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Yip M.S., Law H.K.W., Tu W. and Lau Y.L., Immune responses of human respiratory epithelia cells to human metapneumovirus and respiratory syncytial virus. IMMUNORIO 2007, 13th International Congress of Immunology, Rio de Janeiro-Brazil, 21-25 August 2007.

 

Researcher : Law HY

List of Research Outputs

 

Lee D.C.W., Mok K.P., Law H.Y., Tam H.M., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of interferon dysregulation and virus-induced cell death in Avian-Influenza H5N1 infections, Health Research Symposium 2007: Building bridges between research, practice & policy, September 29,. 2007.

 

Researcher : Lee DCW

List of Research Outputs

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Dysregulation of the Interferon-gamma Signal Transduction: Suppression of Jak/STAT Pathways and Implication for Opportunistic Infections, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 101.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Tat protein inhibits interferon-gamma signaling by suppressing STAT 1 activation: implications for AIDS pathogenesis and opportunistic infections, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Oxford, England, September 16-19. 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H. and Lau A.S.Y., Application of Genomics and cell signaling technologies to investigate traditional Chinese medicine: Panex Ginseng and its immunomodulatory effects, NHClaims 2007 Congress, Naantali, Finland, November 7-9. 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H., Rong J., Tam P.K.H. and Lau A.S.Y., Application of Platform Technologies to Investigate the Immunomodulatory Effects of Ginseng, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Tam P.K.H. and Lau A.S.Y., Application of platform technologies to investigate the immunomodulatory effects of Ginseng, 4th International Think Tank Forum, Faculty of Medicine, The University of Hong Kong, November 14-16. 2007.

 

Lee D.C.W., Chua D.T.T., Wei W.I., Sham J.S.T. and Lau A.S.Y., Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from Nasopharyngeal carcinoma, Biomedicine & Pharmacotherapy. 2007, 61: 520-526.

 

Lee D.C.W., Mok K.P., Law H.Y., Tam H.M., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of interferon dysregulation and virus-induced cell death in Avian-Influenza H5N1 infections, Health Research Symposium 2007: Building bridges between research, practice & policy, September 29,. 2007.

 

Li C.B., Yim H.C.H., Lee D.C.W. and Lau A.S.Y., Best Abstract Award at the Annual Scientific Meeting and General Meeting 2008, Hong Kong Society for Immunology. 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, Annual Scientific Meeting and General Meeting of Hong Kong Society for Immunology 2008 . 2008.

 

Tam H.M., Lee D.C.W. and Lau A.S.Y., Molecular Mechanisms of the Hyper-induction of TNF-a by Avian Influenza in Human Macrophages, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Yim H.C.H., Li C.B., Lau A.S.Y. and Lee D.C.W., HIV-1 Tat plays a role in dysregulating lipopolysaccharide-induced cytokine expression: implications for immune defects in AIDS, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Researcher : Lee PPW

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Dong J., Lee T.L., Lee P.P.W., Ho M.H.K., Wong W.H.S. and Lau Y.L., Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 143.

 

Lau Y.L., Dong J., Lee T.L., Lee P.P.W., Ho M.H.K. and Wong W.H.S., Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus, Pediatrics. 2008, 121: S161-2.

 

Lee P.P.W., Clinical quiz 28, http://www.hku.hk/paed/student area/clinical quiz . 2008.

 

Lee P.P.W. and Wong K.K.Y., Clinical quiz 29, http://www.hku.hk/paed/student area/clinical quiz . 2008.

 

Lee P.P.W. and Wong B.Y.H., Clinical quiz 30, http://www.hku.hk/paed/student area/clinical quiz . 2008.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 142.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus: A close link with long-term disease damage, Pediatrics. 2008, 121 (Suppl 2): S162.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Lee P.P.W., Jiang L.P., Wang X.C., Chan K.W., Tu W. and Lau Y.L., Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor b1 deficiency, European Journal of Pediatrics. Springer, 2008, 167: 231-232.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 34.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 115.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y. and Lau Y.L., Teaching and Learning Medical Genetics - Evaluation of an Interactive Genetics Workshop for Pediatric Clerkship Students, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 103.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y., Yang W. and Lau Y.L., Teaching and Learning Medical Genetics – An Interactive Genetics Workshop for Pediatric Clerkship Students , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Young Investigators Award, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008.

 

Lee T.L., Ho M.H.K., Lee P.P.W. and Lau Y.L., Thalidomide is a Promising DMARD in Achieving Remission Among Children with Refractory Enthesitis-Related Juvenile Idiopathic Arthritis (ERA), The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 81.

 

Researcher : Lee SL

List of Research Outputs

 

Lee S.L., From prevalence of childhood asthma to air pollution, Health Research Symposium, Hong Kong, 29 September 2007. 24.

 

Lee S.L., Limited resources - what to do?, Annual Scientific Meeting, The Hong Kong Sleep Society, 29 September 2007. 9.

 

Researcher : Lee TL

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Chan K.W., Lee P.P.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 125.

 

Cheuk D.K.L., Lee T.L., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Chiang A.K.S., Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children, Journal of neurooncology. 2008, 86: 337-347.

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Dong J., Lee T.L., Lee P.P.W., Ho M.H.K., Wong W.H.S. and Lau Y.L., Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 143.

 

Ho M.H.K., Tung Y.L., Lee T.L., Tsoi N.S. and Lau Y.L., Letter to the Editor: Anaphylaxis to Paracetamol, Journal of Paediatrics and Child Health. 2008, 44: 746-753.

 

Ho M.H.K., Chan E.Y.T., Lee T.L. and Lau Y.L., The application of allergy tests in childhood allergy, Hong Kong Journal of Dermatology Venerology. 2008, 16: 77-91.

 

Lau Y.L., Dong J., Lee T.L., Lee P.P.W., Ho M.H.K. and Wong W.H.S., Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus, Pediatrics. 2008, 121: S161-2.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 142.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus: A close link with long-term disease damage, Pediatrics. 2008, 121 (Suppl 2): S162.

 

Lee P.P.W., Chan K.W., Law H.K.W., Lee T.L. and Lau Y.L., Selective in vivo reversion of an inherited WASP duplication mutation to normal in T-cell lineages, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 35.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 34.

 

Lee P.P.W., Lee T.L., Ho M.H.K. and Lau Y.L., Suboptimal clinical efficacy of methotrexate in Chinese children with enthesitis-related juvenile idiopathic arthritis, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 115.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Lee T.L., Ho M.H.K., Lee P.P.W. and Lau Y.L., Thalidomide is a Promising DMARD in Achieving Remission Among Children with Refractory Enthesitis-Related Juvenile Idiopathic Arthritis (ERA), The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 81.

 

Researcher : Leung CSY

List of Research Outputs

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Li CB

List of Research Outputs

 

Chan G.C.F., Li C.B., Mo F.Y. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: Its impacts on BMT & tissue engineering. , 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港 28 June 2008, 2008.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Interaction of IL-10 and Th1 Cytokines in Mycobacterial Evasion of Immunity, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of BCG-induced immune responses, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), 16-19 September 2007, Oxford, England. 2007.

 

Chan M.P., Cheung B.K.W., Li C.B. and Lau A.S.Y., Modulation of Mycobacteria-induced Immune Evasion: IFNg and IL-12 Suppression of BCG-induced IL-10 Expression, International Society for Interferon and Cytokine Research 2007 (abstract published in the “Journal of Intrerferon & Cytokine Research” Vol 27 No. 8 August 2007), Oxford, UK. 2007.

 

Cheng M., Xing B., Li C.B., Cheung B.K.W. and Lau A.S.Y., Interferon-gamma regulation of TNF-alpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells., Internatl J Cancer. 2007, 121: 1190-6.

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Dysregulation of the Interferon-gamma Signal Transduction: Suppression of Jak/STAT Pathways and Implication for Opportunistic Infections, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 101.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Tat protein inhibits interferon-gamma signaling by suppressing STAT 1 activation: implications for AIDS pathogenesis and opportunistic infections, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Oxford, England, September 16-19. 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H. and Lau A.S.Y., Application of Genomics and cell signaling technologies to investigate traditional Chinese medicine: Panex Ginseng and its immunomodulatory effects, NHClaims 2007 Congress, Naantali, Finland, November 7-9. 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H., Rong J., Tam P.K.H. and Lau A.S.Y., Application of Platform Technologies to Investigate the Immunomodulatory Effects of Ginseng, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Tam P.K.H. and Lau A.S.Y., Application of platform technologies to investigate the immunomodulatory effects of Ginseng, 4th International Think Tank Forum, Faculty of Medicine, The University of Hong Kong, November 14-16. 2007.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Best Oral Presentation Award, The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases, The Hong Kong Society For Paediatric Immunology And Infectious Diseases. 2008.. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Cellular signaling events in cytokines and sulphamethoxasole interactions, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 Tat Plays a Role in Dysregulating Lipopolysaccharide-Induced Cytokine Expression: Implications for Immune Defects in Aids, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 15 March. 2008.

 

Yim H.C.H., Li C.B., Lau A.S.Y. and Lee D.C.W., HIV-1 Tat plays a role in dysregulating lipopolysaccharide-induced cytokine expression: implications for immune defects in AIDS, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune response induced by lipopolysaccharides, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune responses induced by lipopolysaccharides, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Researcher : Li J

List of Research Outputs

 

Chan B.P., Hui T.Y., Yeung C.W., Li J., Mo F.Y. and Chan G.C.F., Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine, Biomaterials. 2007, 28: 4652-4666.

 

Chan G.C.F., Li J., Mo I. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: its impacts on BMT & tissue engineering, 第十三屆全國小兒血液病學術會議, 湖南宜昌, 中國, 8-11 November 2007, 2007, 161-162.

 

Fung K.L., Li J., Liang R.H.S. and Chan G.C.F., The Effect of Microtubule-targeting Chemotherapeutic Agents on the Surival of Bone-marrow Derived Mesenchymal Stem Cell, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Li YH

List of Research Outputs

 

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 (Transforming Growth Factor-Beta Receptor 2) mutations in Chinese with Marfan syndrome (MFS) and related phenotypes using denaturing high performance liquid chromatography (DHPLC) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 mutations in Chinese with marfan syndrome (MFS) and related phenotypes using DHPLC, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel transforming growth factor2 receptor 2 mutations in Chinese patients with marfan syndrome, Pediatrics. 2008, 121: s116.

 

Wong V.C.N. and Li Y.H., Rett syndrome: prevalence among Chinese and a comparison of MECP2 mutations of classic Rett syndrome with other neurodevelopmental disorders, Journal of Child Neurology. 2007, 22(12): 1397-1400.

 

Researcher : Liang X

List of Research Outputs

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 153.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., Impact of Right Ventricular Dilation on Three Dimensional Left Ventricular Mycardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung E.W.Y., Liang X., Lam W.W.M. and Cheung Y.F., The Impact of Right Ventricular Dilation on Regional Left Ventricular Function in Patients After Tetralogy of Fallot Repair: A Novel Assessment by Speckle Tracking Echocardiography, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Cheung Y.F., Liang X., Chan G.C.F., Wong S.J. and Ha S.Y., Diastolic Myocardial Deformation is Associated with Myocardial Iron Load in Patients with Beta-Thalassaemia Major: A Speckle Tracking Echocardiographic Study, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Liang X., Cheung E.W.Y. and Wong S.J., Real-Time Three-Dimensional Left Ventricular Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 104.

 

Chow P.C., Liang X., Lam W.W., Cheung E.W.Y. and Cheung Y.F., Abstract 1965: Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, American Heart Association 2007, Abstract in: Circulation 2007;116:II423-424. 2007, 116: 423-424.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function, Heart. 2008, 94: 855-859.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y. and Cheung Y.F., Nowel Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 83.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Right Ventricular Physiology After Biventricular Repair of Pulmonary Atresia with Intact Ventricular Septum, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Rigth Ventricular Physiology after Biventricular Repair of Pulmonary Atresia and Intact Ventricular Septum, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 232.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dysynchrony after Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Oveerload, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 231.

 

Researcher : Lin SS

List of Research Outputs

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Dysregulation of the Interferon-gamma Signal Transduction: Suppression of Jak/STAT Pathways and Implication for Opportunistic Infections, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 101.

 

Lau A.S.Y., Cheng M., Li C.B., Lin S.S. and Lee D.C.W., HIV Tat protein inhibits interferon-gamma signaling by suppressing STAT 1 activation: implications for AIDS pathogenesis and opportunistic infections, The 2007 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Oxford, England, September 16-19. 2007.

 

Researcher : Low LCK

Project Title:

IDF WPR Childhood and Adolescence Diabcare 2003 - an audit and benchmarking study on Type 2 diabetes management in childhood and adolescence in Western Pacific region countries

Investigator(s):

 

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/2003

 

Abstract:

To describe diabetes control, diabetes management and complication status in children and adolescents with Type 2 diabetes mellitus in the WPR: a) to investigate the relationship between the above factors; b) to provide means of measuring the quality of diabetes management.

 

List of Research Outputs

 

Chung P.H.Y., Wong K.K.Y., Tsoi N.S., Low L.C.K., Khoo U.S. and Tam P.K.H., A diagnostic challenge in the management of unlocalised persistent hyperinsulinaemic hypoglycaemia of infancy: a case report and review of literature, Hong Kong Journal of Paediatrics (new series). 2008, 13: 125-129.

 

Craig M.E., Jones T.W., Silink M., Yeo J.P. and Low L.C.K., Diabetes care, glycemic control, and complications in children with type 1 diabetes from Asia and the Western Pacific Region, Journal of Diabetes and Its Complications. Elsevier, 2007, 21: 280-287.

 

Fung C.W., Siu S., Mak C., Poon G.W.K., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly - transaldolase deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Lee P.P.W., Ooi C.G.C., Khong P.L., Chan G.C.F., Lam W., Low L.C.K. and Ha S.Y., Hepatic and pancreatic magnetic resonance imaging in patients with transfusion-dependent beta-thalassemia - Relationship between iron overload and abnormal glucose metabolism, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 117.

 

Low L.C.K., 2nd Editorial Board of Chinese Journal of Contemporary Pediatrics, 2008.

 

Low L.C.K., Adrenal disorders, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., Board Director, Paediatrics, Journal of Paediatrics, Obstetrics & Gynaecology, (1997-2007). 2007.

 

Low L.C.K., Chairman of Day 1 of Idiopathic Short Stature (ISS) Consensus Conference, Santa Monica, California, 17-20 October 2007. 2007.

 

Low L.C.K., Chairman, Board of Studies of Master of Medical Sciences, Li Ka Shing Faculty of Medicine. The University of Hong Kong (2003 - date) , 2007.

 

Low L.C.K., Chief Editor of Hong Kong Journal of Paediatrics , 2008.

 

Low L.C.K., 客座教授, Children's Hospital of Fudan University, Shanghai, PR China, January 2008. 2008.

 

Low L.C.K., 兒童和青少年代謝綜合証, Chinese Journal of Pediatrics. 2007, 45(6): 404-407.

 

Low L.C.K., Chinese Journal of Pediatrics, 2008.

 

Low L.C.K., Council Member of Asia Pacific Paediatric Endocrine Society (September 2004 - date) , 2007.

 

Low L.C.K. and Craig M., Diabetes, insulin resistance, dyslipidaemia, 9th Asia Pacific Paediatric Endocrine Society Fellows Meeting, Taipei, Taiwan, 3-5 December 2007.

 

Low L.C.K., Diagnosis and Management of Central Precicious Puberty, Chang-Gung Children Hospital, Taipei, Taiwan, 6 December 2007. 2007.

 

Low L.C.K., Diagnosis and Management of Precocious Puberty, Takeda Pharmaceutical Company Limited: Advisory Board Meeting of Management approach for Central Precocious Puberty, Tokyo, Japan (9 March 2008). 2008.

 

Low L.C.K., Disorder of sex development, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., Disorders of Calcium and Phosphate Metabolism, Advances in the Diagnosis and Management of Pediatric Genetic Metabolic and Endocrine Disorders, Tongji Hospital of Tongji Medical College of Huazhong University of Science & Technology, Wuhan, PR China, 20-22 June 2008. 2008.

 

Low L.C.K., Disorders of calcium and phosphate metabolic in children, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., Disorders of sex differentiation, 9th National Meeting of Pediatric Endocrinology and Inherited Metabolic Diseases, Huangshan, PRC, 5-9 November 2007. 第九屆全國兒科內分泌、遺傳代謝病學術會議.

 

Low L.C.K., Disorders of sexual differentiation, 9th Asia Pacific Paediatric Endocrine Society Fellows Meeting, Taipei, Taiwan, 3-5 December 2007.

 

Low L.C.K., Editor-in-Chief , Hong Kong Journal of Paediatrics. 2007.

 

Low L.C.K., Editorial Board Member (Jan 2005 - date), Pediatric Endocrinology Reviews. 2007.

 

Low L.C.K., Editorial Board Member, Journal of Paediatric Endocrinology & Metabolism (JPEM), (1997-date). 2007.

 

Low L.C.K., Exp Review of Endocrinology & Metabolism. 2008.

 

Low L.C.K., Fellow , Academy of Medicine, Republic of Singapore. 2007.

 

Low L.C.K., Honorary Advisor, Hong Kong Juvenile Diabetes Association (2001 - 2008), 2007.

 

Low L.C.K., Honorary Advisor, Hong Kong Society of Paediatric Endocrinology & Metabolism, January 2008. 2008.

 

Low L.C.K., Honorary Life Member, Hong Kong Paediatric Society, 2008. 2008.

 

Low L.C.K., Iodine deficiency and perinatal thyroid function, 碘質缺乏與新生兒甲狀腺功能, 碘質缺乏與新生兒甲狀腺功能, 西藏自治區人民醫院, 拉薩, 泰北, 中國, Lihasa, Tibet, 11 July 2007. 西藏自治區人民醫院, 拉薩, 泰北, 中國.

 

Low L.C.K., Journal of Paediatric Endocrinology and Metabolism , 2008.

 

Low L.C.K., Member of the Second Editorial Board of the Chinese Journal of Contemporary Pediatrics since (November 2003-date). 2007.

 

Low L.C.K., Member, Editorial Board (1999-date), Pediatric Diabetes. 2007.

 

Low L.C.K., Member, Grant Review Board, Health, Welfare and Food Bureau of the Hong Kong SAR Government (October 2003 to October 2009) , 2007.

 

Low L.C.K., Member, Intership Subcommittee, Licentiate Committee, Hong Kong Medical Council (1997 - date) , 2007.

 

Low L.C.K., Member, Subcommittee on Pediatric Endocrinology and Inherited Metabolic Diseases of the Chinese Pediatric Assoication of the China Medical Association (2002-2008) , 2007.

 

Low L.C.K., Neonatal hypoglycaemia, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., Paediatic Professional Training in Hong Kong, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., Pediatric Diabetes , 2008.

 

Low L.C.K., Pediatric Endocrine Reviews , 2008.

 

Low L.C.K., Pediatric Research , 2008.

 

Low L.C.K., President of the Hong Kong College of Paediatricians (November 2006 - 2009), 2007.

 

Low L.C.K., Wong W.H.S., Lam B.C.C., Sheng H.P. and Wong W., Role of nutritional intake and total energy expenditure on growth of babies born with intrauterine growth retardation, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 59.

 

Low L.C.K., The diagnosis and management of precocious puberty, Wellington Children's Hospital (University of Otago), Wellington, New Zealand, 2 April 2008. 2008.

 

Low L.C.K., Thyroid Disorders in Children, Advances in the Diagnosis and Management of Pediatric Genetic Metabolic and Endocrine Disorders, Tongji Hospital of Tongji Medical College of Huazhong University of Science & Technology, Wuhan, PR China, 20-22 June 2008. 2008.

 

Low L.C.K., Turner Syndrome, Children's Hospital of Fudan University, PR China, 14-20 January 2008. 2008.

 

Low L.C.K., 主任委員, 第七屆粵港兒科學術交流會暨第一屆港粵滬渝學術交流會, 香港醫學專科學院賽馬會大樓, 林百欣演講廳, 28 June 2008, 2008.

 

Low L.C.K., 性分化異常, 浙江大學醫學院附屬兒童醫院:兒童生長發育相關疾病研究進展, 淅江, 中國, (April 2008), 2008.

 

Low L.C.K., 兒童發育期的各種問題, 迪慶洲民族中等專門學校研討會, 中國, 25-28 May 2008, 2008.

 

Low L.C.K., 客座教授, 青海省婦女兒童醫院, 2007.

 

Low L.C.K., 主任委員，第七屆粵港兒科學術交流會暨第一屆港粵滬渝學術交流會，香港醫學專科學院賽馬會大樓，林百欣演講廳, June 2008, 2008.

 

Mak C.M., Siu T.S., Lam C.W., Chan G.C.F., Poon G.W.K., Wong K.Y., Low L.C.K., Tang N.L., Li S.K., Lau K.Y., Kwong N.S. and Tam S., Complete recovery from acute encephalopathy of late-onset ornithine transcarbamylase deficiency in a 3-year-old boy, Journal of Inherited Metabolic Disease. Springer, 2007, 30(6): 981.

 

Mok P.W.K., Wong W.H.S., Lee P.W.H. and Low L.C.K., Is Teenage Obesity Associated with Depression and Low Self-Esteem?: A Pilot Study, Hong Kong Journal of Paediatrics. 2008, 13: 30-38.

 

Researcher : Lun KS

List of Research Outputs

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 (Transforming Growth Factor-Beta Receptor 2) mutations in Chinese with Marfan syndrome (MFS) and related phenotypes using denaturing high performance liquid chromatography (DHPLC) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 mutations in Chinese with marfan syndrome (MFS) and related phenotypes using DHPLC, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel transforming growth factor2 receptor 2 mutations in Chinese patients with marfan syndrome, Pediatrics. 2008, 121: s116.

 

Koh C., Yung T.C., Lun K.S. and Cheung Y.F., Left Ventricular Noncompaction in Children, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Koo S.D., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Cardiovascular symptoms and signs in evaluating cardiac murmurs in children, Pediatrics International. 2008, 50: 145-149.

 

Researcher : Mak HS

List of Research Outputs

 

Chan K.W., Lee T.L., Jiang L., Chen T.X., Lee B.W., Wang X., Liew W.K., Li G., Tan A.M., Noh L.M., Lim D.L.C., Fok S.F.S., Mak H.S., Lee P.P.W., Yang X. and Lau Y.L., Resource of primary immunodeficiency diseases: genetic diagnosis in Hong Kong, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 217.

 

Lee P.P.W., Chan K.W., Jiang L., Chen T., Li C., Lee T.L., Mak H.S., Fok S.F.S., Yang X. and Lau Y.L., Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease, The Pediatric Infectious Disease Journal. Lippincott Williams & Wilkins, 2008, 27(3): 224-230.

 

Researcher : Mao H

List of Research Outputs

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Researcher : Mao H

List of Research Outputs

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Researcher : Mo FY

List of Research Outputs

 

Chan B.P., Hui T.Y., Yeung C.W., Li J., Mo F.Y. and Chan G.C.F., Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine, Biomaterials. 2007, 28: 4652-4666.

 

Chan G.C.F., Li C.B., Mo F.Y. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: Its impacts on BMT & tissue engineering. , 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港 28 June 2008, 2008.

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Researcher : Mo FY

List of Research Outputs

 

Chan B.P., Hui T.Y., Yeung C.W., Li J., Mo F.Y. and Chan G.C.F., Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine, Biomaterials. 2007, 28: 4652-4666.

 

Chan G.C.F., Li C.B., Mo F.Y. and Chan S., Effects of extrinsic factors on the growth and differentiation of human marrow derived mesenchymal stem cells: Its impacts on BMT & tissue engineering. , 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港 28 June 2008, 2008.

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Researcher : Mok KP

List of Research Outputs

 

Lee D.C.W., Mok K.P., Law H.Y., Tam H.M., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of interferon dysregulation and virus-induced cell death in Avian-Influenza H5N1 infections, Health Research Symposium 2007: Building bridges between research, practice & policy, September 29,. 2007.

 

Researcher : Mok SP

List of Research Outputs

 

Cheuk D.K.L., Mok S.P., Lee A.C., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT, Bone Marrow Transplant (Epub June 2008). 2008.

 

Researcher : Ng MW

List of Research Outputs

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Researcher : Ng P

List of Research Outputs

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Ng P., Yang W. and Lau Y.L., Systemic Lupus Erythematosus In Hong Kong Chinese, 12th Research Postgraduate Symposium, Hong Kong, 11 Dec, 2007.

 

Researcher : Ng P

List of Research Outputs

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Ng P., Yang W. and Lau Y.L., Systemic Lupus Erythematosus In Hong Kong Chinese, 12th Research Postgraduate Symposium, Hong Kong, 11 Dec, 2007.

 

Researcher : Poon GWK

List of Research Outputs

 

Fung C.W., Siu S., Mak C., Poon G.W.K., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly - transaldolase deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Mak C.M., Siu T.S., Lam C.W., Chan G.C.F., Poon G.W.K., Wong K.Y., Low L.C.K., Tang N.L., Li S.K., Lau K.Y., Kwong N.S. and Tam S., Complete recovery from acute encephalopathy of late-onset ornithine transcarbamylase deficiency in a 3-year-old boy, Journal of Inherited Metabolic Disease. Springer, 2007, 30(6): 981.

 

Researcher : Qin G

List of Research Outputs

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Researcher : Siu HO

List of Research Outputs

 

Siu H.O., Yang W., Lau C.S., Chan T.M., Wong R.W.S., Wong W.H.S. and Lau Y.L., Association of a Haploytpe of IRF5 Gene with Systemic Lupus Erythematosus in Chinese, Journal of Rheumatology. 2008, 35(2): 360-362.

 

Researcher : So LY

List of Research Outputs

 

Lau S.K.P., Yip C.Y., Tsoi H.W., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV associated with acute respiratory illness in children, Journal of Clinical Microbiology. 2007, 45(11): 3655-3664.

 

Researcher : Tam HM

List of Research Outputs

 

Lee D.C.W., Mok K.P., Law H.Y., Tam H.M., Cheung C.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of interferon dysregulation and virus-induced cell death in Avian-Influenza H5N1 infections, Health Research Symposium 2007: Building bridges between research, practice & policy, September 29,. 2007.

 

Tam H.M., Lee D.C.W. and Lau A.S.Y., Molecular Mechanisms of the Hyper-induction of TNF-a by Avian Influenza in Human Macrophages, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Ting JY

List of Research Outputs

 

Ting J.Y., Lam B.C.C., Wong K.Y., Wong R.M.S. and Wong M.S.C., Changes in Mortality, Morbidity and Early Neurodevelopmental Outcomes Among Extremely-Low-Birth-Weight (ELBW) Infants Born in a Tertiary Perinatal Centre in Hong Kong, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 118.

 

Researcher : To KW

List of Research Outputs

 

Hui K.F., To K.W. and Chiang A.K.S., The Effect of Histone Deacetylase Inhibitors on Lytic Cycle Activation of Epstein-Barr Virus (EBV) in EBV-associated Malignancy, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Tong PH

List of Research Outputs

 

Tong P.H., Man C.W.Y., Tsao G.S.W. and Chan G.C.F., Arsenic Trioxide Induced All Cycle Arrest in Neuroblastoma Cells with or without MYCN Over-Expression & the Response Had No Correlation with their Effect on Chromosomal Passenger Complex, Advances in Neuroblastoma Research 2008, Chiba, Japan, 21-24 May 2008. 140.

 

Tong P.H., Man C.W.Y., Tsao G.S.W. and Chan G.C.F., Arsenic Trioxide induced G2/M phase arrest in neuroblastoma cells with or without MYCN over-expression & the response had no correlation with their effect on chromosomal passenger complex., 第七屆粵港兒科學術文流會暨第一屆港粵滬渝學術交流會, 香港. 28 June 2008, 2008.

 

Tong P.H. and Chan G.C.F., Sub-lethal Concentration of Arsenic Trioxide may Enhance Proliferation or Mitochondrial Activity of Arsenic Resistant Neuroblastoma Cell Lines, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Researcher : Tsang AMC

List of Research Outputs

 

Chee Y.Y., Yung A.W.Y. and Tsang A.M.C., Review of do-not-resusciate orders in paediatric patients, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 41.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LC1) in Hong Kong: comparison with USA, 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 135.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LCI) in Hong Kong: Comparison with USA (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., [Letters to the Editor] Neurologic complications in children hospitalized with influenza: Comparison between USA and Hong Kong, Journal of Pediatrics. 2007, 151(5): e17-e18.

 

Luk H.M., Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurological complications in hospitalized children with laboratory confirmed influenza in Hong Kong: comparison with USA, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Researcher : Tso HW

List of Research Outputs

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Researcher : Tsoi NS

List of Research Outputs

 

Chung P.H.Y., Wong K.K.Y., Tsoi N.S., Low L.C.K., Khoo U.S. and Tam P.K.H., A diagnostic challenge in the management of unlocalised persistent hyperinsulinaemic hypoglycaemia of infancy: a case report and review of literature, Hong Kong Journal of Paediatrics (new series). 2008, 13: 125-129.

 

Ho M.H.K., Tung Y.L., Lee T.L., Tsoi N.S. and Lau Y.L., Letter to the Editor: Anaphylaxis to Paracetamol, Journal of Paediatrics and Child Health. 2008, 44: 746-753.

 

Tsoi N.S., Contributor to book on Living Donor Liver Transplantation. 2007.

 

Researcher : Tu W

Project Title:

The Role of Natural Killer Cells in Pathogenesis of Avian Influenza Virus Infection

Investigator(s):

Tu W, Lau YL, Peiris JSM

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

Introduction Influenza A (fluA) virus is a cause of substantial annual morbidity and mortality worldwide. Potential for the emergence of a new pandemic strain, through natural reassortment, e.g. avian fluA, is a major concern [1-6]. The innate immunity as the first line of host immune system is thought to be the main defense mechanism against this particular highly pathogenic virus infection. Natural killer (NK) cells function as a key factor in innate immune responses to intracellular pathogens, such as viruses [7, 8]. NK cells can directly lyse fluA virus-infected cells by exocytosis of perforin and granzymes and secrete cytokines, such as interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha, which mediate their immune responses to virus infection [7-10]. The NK cell-mediated killing is controlled by activating and inhibitory receptors [11]. NK cell activating receptors include the natural cytotoxicity receptors (e.g. NKp30, NKp44 and NKp46), NKG2D, NKRP1 and CD16 [11]. Among of these, NKp46 and NK-44 have been demonstrated to play essential roles for the cytotoxic activities of NK cells against fluA viruses [11-14]. The inhibitory receptors include the killer cell Ig-like receptor (KIR) family, the C-type lectin family and the Ig-like transcript leukocyte Ig-like receptor (LIR) family [11]. The activity of NK cells is dependent on the balance of signals from the activating and inhibitory receptors [8, 11]. In addition, NK cells are activated by cytokines such as IL-12 and IFN-alpha, which are products of activated macrophage and dendritic cells [8, 11]. The distinctive features of avian fluA, in particular H5N1 affected patients include a primary viral pneumonia complicated acute respiratory distress, multiple organ dysfunction and haemophagocytosis [1, 15-18]. All of these are associated with the hyperinflammatory responses [1, 15-18]. Furthermore, the fatal outcome of H5N1 infection is associated with high viral load and hyperinflammatory cytokines [19]. Professor Peiris and our group have been demonstrated that these hyperinflammatory cytokines and chemokines are derived from H5N1-infected macrophages, and H5N1-infected macrophages are over-activated as compared with H1N1-infected cells [15-18]. However, the underlying mechanisms of macrophage over-activation and hyperinflammatory cytokines and chemokines are still unknown. It has been demonstrated that NK cell dysfunction is associated with systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome [20]. Moreover, the overproduction of TNF-alpha, one of the hyperinflammatory cytokines found in H5N1 infected patients, was also indicated to associate with the low cytotoxic activity of NK cells in human [21]. Therefore, we speculate that hyperinflammatory cytokines and macrophage over-activation are associated with dysfunctions of NK cells in H5N1 infected-patients. Hypothesis We hypothesize that there are dysfunctions of NK cells in H5N1 infected-patients, and these dysfunctions are due to the increased apoptosis or decreased cytotoxicity of NK cells. We further hypothesize that H5N1-infected macrophages may induce the apoptosis or inhibit the cytotoxicity of NK cells through the cell-cell contact or the overproduction of inflammatory cytokines released from virus-infected macrophages. Aims 1. To determine whether H5N1 virus can induce an increased NK cell apoptosis or death, as compared to H1N1 virus. 2. To determine whether H5N1 virus can inhibit NK cell cytotoxicity, as compared to H1N1 virus. 3. To determine whether the increased apoptosis and death, or decreased cytotoxicity of NK cells is mediated by cell-cell contract or soluble molecules released from H5N1-infected cells. References: 1. Yuen KY, Chan PK, Peiris M, Tsang DN, Que TL, Shortridge KF, Cheung PT, To WK, Ho ET, Sung R, Cheng AF. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet. 1998;351(9101): 467-71 2. Guan Y, Poon LL, Cheung CY, Ellis TM, Lim W, Lipatov AS, Chan KH, Sturm-Ramirez KM, Cheung CL, Leung YH, Yuen KY, Webster RG, Peiris JS. H5N1 influenza: a protean pandemic threat. Proc Natl Acad Sci U S A. 2004, 101(21):8156-61. 3. Webby RJ, Webster RG. Are we ready for pandemic influenza? Science. 2003;302(5650):1519-22. 4. Zeitlin GA, Maslow MJ. Avian Influenza. Curr Infect Dis Rep. 2005;7(3):193-199. 5. Shortridge KF, Peiris JS, Guan Y. The next influenza pandemic: lessons from Hong Kong. J Appl Microbiol. 2003;94 Suppl:70S-79S. 6. Peiris JS, Yu WC, Leung CW, Cheung CY, Ng WF, Nicholls JM, Ng TK, Chan KH, Lai ST, Lim WL, Yuen KY, Guan Y. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet. 2004;363(9409):617-9. 7. Cerwenka A, Lanier LL. Natural killer cells, viruses and cancer. Nat Rev Immunol. 2001;1(1):41-9. 8. Lodoen MB, Lanier LL. Natural killer cells as an initial defense against pathogens. Curr Opin Immunol. 2006 Aug;18(4):391-8. 9. Trinchieri G. Biology of natural killer cells. Adv Immunol. 1989;47:187-376. 10. Robertson MJ, Ritz J. Biology and clinical relevance of human natural killer cells. Blood. 1990;76(12):2421-38. 11. Kirwan SE, Burshtyn DN. Regulation of natural killer cell activity. Curr Opin Immunol. 2007: 19:1-9. 12. Mandelboim O, Lieberman N, Lev M, Paul L, Arnon TI, Bushkin Y, Davis DM, Strominger JL, Yewdell JW, Porgador A. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 2001;409(6823):1055-60. 13. Gazit R, Gruda R, Elboim M, Arnon TI, Katz G, Achdout H, Hanna J, Qimron U, Landau G, Greenbaum E, Zakay-Rones Z, Porgador A, Mandelboim O. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 2006; 7(5):517-23. 14. Arnon TI, Achdout H, Lieberman N, Gazit R, Gonen-Gross T, Katz G, Bar-Ilan A, Bloushtain N, Lev M, Joseph A, Kedar E, Porgador A, Mandelboim O. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. Blood. 2004;103(2):664-72. 15. Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JS. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1)viruses: a mechanism for the unusual severity of human disease? Lancet. 2002;360(9348):1831-7. 16. To KF, Chan PK, Chan KF, Lee WK, Lam WY, Wong KF, Tang NL, Tsang DN, Sung RY, Buckley TA, Tam JS, Cheng AF. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol. 2001;63(3):242-6. 17. Zhou J, Law HK, Cheung CY, Ng IH, Peiris JS, Lau YL. Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages. J Infect Dis. 2006;193(7):945-53. 18. Zhou J, Law HK, Cheung CY, Ng IH, Peiris JS, Lau YL. Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses. J Infect Dis. 2006 Jul 1;194(1):61-70. 19. de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Hoang DM, Chau NV, Khanh TH, Dong VC, Qui PT, Cam BV, Ha do Q, Guan Y, Peiris JS, Chinh NT, Hien TT, Farrar J. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med. 2006;12(10):1203-7. 20. Villanueva J, Lee S, Giannini EH, Graham TB, Passo MH, Filipovich A, Grom AA. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther. 2005; 7:R30-7. 21. Mysliwska J, Bryl E, Zorena K, Balon J, Foerster J, Mysliwski A. Overactivity of tumor necrosis factor-alpha but not interleukin 6 is associated with low natural killer cytotoxic activity in the elderly. Gerontology. 1997;43(3):158-67.

 

List of Research Outputs

 

Lee P.P.W., Jiang L.P., Wang X.C., Chan K.W., Tu W. and Lau Y.L., Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor b1 deficiency, European Journal of Pediatrics. Springer, 2008, 167: 231-232.

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Tu W., Cytomegalovirus Immunity in Solid Organ Transplantation, Keynote speaker in 7th National Congress of Pediatric Immunology, Qindao, PR China, October 2007.

 

Tu W., Evaluation of CMV-specific T cells in children, Hong Kong Society of Flow Cytometry. 2008.

 

Tu W., Host Immune Responses against Human and Avian Influenza Viruses, Keynote speaker in Jian University, PR China, December 2007.

 

Tu W., Humoral and cellular immune responses to influenza viruses in children, Chinese National Pediatric Immunology Society. 2008.

 

Yip M.S., Law H.K.W., Tu W. and Lau Y.L., Immune responses of human respiratory epithelia cells to human metapneumovirus and respiratory syncytial virus. IMMUNORIO 2007, 13th International Congress of Immunology, Rio de Janeiro-Brazil, 21-25 August 2007.

 

Researcher : Wang M

List of Research Outputs

 

Wong H.L., Wang M., Cheung P.T., Yao K.M. and Chan B.P., A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity, Biomaterials. Elsevier Ltd., 2007, 28: 5369-5380.

 

Researcher : Wang P

List of Research Outputs

 

Cheuk D.K.L., Wang P., Lee T.L., Chiang A.K.S., Ha S.Y., Lau Y.L. and Chan G.C.F., Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation, Bone Marrow Transplantation. Nature Publishing, 2007, 40: 935-944.

 

Researcher : Wong CH

List of Research Outputs

 

Wong C.H., Yip H.K. and Chan G.C.F., Effect of Various Culture Surfaces on Human Mesenchymal Stem Cells, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Wong C.H., Member (Since 1990), World Federation of Neurology. 2008.

 

Researcher : Wong CL

List of Research Outputs

 

Wong C.L. and Wong V.C.N., Any Relationship for Classifying Epilepsy Using Western Medicine versus Traditional Chinese Medicine - A Cross-sectional Study of 40 Children, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Effect of Acupuncture in a Child with Chronic Bell's Palsy, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Pilot Study in the Use of Body Acupuncture in 7 Children with Autism, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Pilot Study of Acupuncture in Children with Chronic Neurological Diseases, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Relationship for Classifying Epilepsy Using Western Medicine vs Traditional Chinese Medicine - A Cross-sectional Study of 40 Cases, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007.

 

Wong C.L. and Wong V.C.N., Study of Children with Autism Spectrum Disorders Using Symptom Differentiation of Traditional Chinese Medicine (TCM), 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Use of Acupuncture in Management of Spasticity, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong V.C.N. and Wong C.L., Effect of Acupuncture in a Child with Chronic Bell's Palsy, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N. and Wong C.L., Pilot Study in the Use of Body Acupuncture in 7 Children with Autism Spectrum Disorder, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Researcher : Wong KT

List of Research Outputs

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Mechanical Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Graet Arteries, The American Journal of Cardiology. Elsevier Inc., 2008, 101: 874-881.

 

Chow P.C., Liang X., Lam W.W.M., Cheung E.W.Y., Wong K.T. and Cheung Y.F., Right Ventricular Dyssynchrony in Patients After Atrial Switch Operation for Transposition of the Great Arteries, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Researcher : Wong KY

List of Research Outputs

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Mak C.M., Siu T.S., Lam C.W., Chan G.C.F., Poon G.W.K., Wong K.Y., Low L.C.K., Tang N.L., Li S.K., Lau K.Y., Kwong N.S. and Tam S., Complete recovery from acute encephalopathy of late-onset ornithine transcarbamylase deficiency in a 3-year-old boy, Journal of Inherited Metabolic Disease. Springer, 2007, 30(6): 981.

 

Ting J.Y., Lam B.C.C., Wong K.Y., Wong R.M.S. and Wong M.S.C., Changes in Mortality, Morbidity and Early Neurodevelopmental Outcomes Among Extremely-Low-Birth-Weight (ELBW) Infants Born in a Tertiary Perinatal Centre in Hong Kong, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 118.

 

Wong K.Y., Wong R.M.S., Wong M.S.C. and Tam S., Reference Values for Thyroid Function Tests in Asian Very Low Birth Weight Infants, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 122.

 

Researcher : Wong MSC

List of Research Outputs

 

Ting J.Y., Lam B.C.C., Wong K.Y., Wong R.M.S. and Wong M.S.C., Changes in Mortality, Morbidity and Early Neurodevelopmental Outcomes Among Extremely-Low-Birth-Weight (ELBW) Infants Born in a Tertiary Perinatal Centre in Hong Kong, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 118.

 

Wong K.Y., Wong R.M.S., Wong M.S.C. and Tam S., Reference Values for Thyroid Function Tests in Asian Very Low Birth Weight Infants, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 122.

 

Researcher : Wong RMS

List of Research Outputs

 

Ting J.Y., Lam B.C.C., Wong K.Y., Wong R.M.S. and Wong M.S.C., Changes in Mortality, Morbidity and Early Neurodevelopmental Outcomes Among Extremely-Low-Birth-Weight (ELBW) Infants Born in a Tertiary Perinatal Centre in Hong Kong, The 4th Congress of Asiang Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 118.

 

Wong K.Y., Wong R.M.S., Wong M.S.C. and Tam S., Reference Values for Thyroid Function Tests in Asian Very Low Birth Weight Infants, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. 122.

 

Researcher : Wong SJ

List of Research Outputs

 

Cheung Y.F., Liang X., Chan G.C.F., Wong S.J. and Ha S.Y., Diastolic Myocardial Deformation is Associated with Myocardial Iron Load in Patients with Beta-Thalassaemia Major: A Speckle Tracking Echocardiographic Study, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Cheung Y.F., Liang X., Cheung E.W.Y. and Wong S.J., Real-Time Three-Dimensional Left Ventricular Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA, 3-6 May 2008. Honolulu, Hawaii, USA, 104.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Right Ventricular Physiology After Biventricular Repair of Pulmonary Atresia with Intact Ventricular Septum, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 97.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Restrictive Rigth Ventricular Physiology after Biventricular Repair of Pulmonary Atresia and Intact Ventricular Septum, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 232.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Overload, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Liang X., Cheung E.W.Y., Wong S.J. and Cheung Y.F., Three-Dimensional Global Left Ventricular Mechanical Dysynchrony after Surgical Repair of Tetralogy of Fallot: Impact of Right Ventricular Volume Oveerload, The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008. 231.

 

Researcher : Wong VCN

Project Title:

Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2

Investigator(s):

Wong VCN

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

Rett syndrome (RTT) is an X-linked dominant neurodegenerative disorder characterized by a period of early normal growth and development followed by regression with loss of speech, acquired motor skills, stereotypic hand movement, and seizures. RTT affects 1 in 15,000 females and is the second leading cause of profound mental retardation in females. RTT is a clinical syndrome without any diagnostic biologic markers and the pathophysiologic changes has not been identified. The diagnosis of RTT is still reliant on clinical criteria. Early diagnosis of RS in the normal developmental period is still impossible. The disease is caused by mutations in the methyl-CpG-binding protein 2 gene (MECP2), and various mutations have been reported. The phenotypic spectrum in both female and male patients is diverse, ranging from very mild to congenital encephalopathy and prenatal lethality. Methyl-CpG binding protein 2 (MECP2) The responible gene, encoding Methyl-CpG binding protein 2 (MECP2) is discovered (1999 Sept 30). (1,2) MECP2 mutations is detected in < 50% of girls with RS by PCR amplification of the coding region. The RTT phenotype of MECP2 mutation is broad with lethality and normality in the two extremes. Findings have suggested that X-Chromosome Inactivation (XCI) pattern is the major determinant of the phenotype in females. MECP2 is an abundant chromosome-binding protein that selectively binds 5-methyl cytosine residues in CpG dinucleotides of mammalian genome. MECP2 has a role as a global transcriptional repressor in vertebrate genome. However, how MECP2 mutation cause RTT is still unclear as only 50% of RS girls has the mutation. MECP2 mutations has been detected by PCR amplification of the coding region. As MECP2 mutations could also involve the highly conserved regions within the 8.5-kb 3’UTR, mutational analysis should expand to include this region as well. Until now, MECP2 mutations has been detected by PCR amplification of the coding region in 60% of girls with RS. Possibly MECP2 mutations in the highly conserved regions within the 8.5-kb 3’UTR are currently underway. Both nonsense and missense mutations have been found. Different single-nucleotide deletion or insertion was found in patients with RS. Others are the nucleotide substitutions, which involve C-T transitions at CpG hotspots except one variant (G-A). Clinical Spectrum of Rett syndrome: The spectrum of phenotypes of MECP2 mutations seems to be much broader. R168X mutation was found in 2 affected sisters and their normal mother. In one family, an 806 del G deletion causing a V288X stop in the transcription-repression domain was identified in a woman with mild neuropyschological problems and skewed X inactivation; in her sister and daughter with classic RS and in her hemizygous son, who died from congenital encephalopathy. This finding suggested that X-chromosome inactivation (XCI) pattern could be the major determinant of the phenotype in females. The severity of RS is believed to be a function of the percentage of cells with active, mutated MECP2 genes. MECP2 gene encodes a protein called MeCP2 that helps to orchestrate the “rests” that certain genes must take during the developmental symphony. If a defective MeCP2 protein is unable to “conduct” gene expression, then a neural chaos will result.MeCP2 is actually just a member of a family of methyl-binding proteins, all of which may help to regulate gene function. Mutations in any of these proteins or their interacting partners may be responsible for atypical RS, autism, severe neonatal encephalopathy, and non-syndromal mental retardation. The spectrum of phenotypes of MECP2 mutations is surprisingly wide with lethality to normality in the two extremes. (3) Even though the mutational types could have contributed to the phenotypes, some findings suggested that the X-chromosome inactivation (XCI) pattern may be the major determinant of the phenotype in females. We had reported MECP2 mutation in a cohort of Chinese girls with RS and autism (2000). (4, 5) We hope to explore the spectrum of phenotypes resulting from MECP2 mutations in the Chinese population. We hope to establish a systemic way of mutational analysis of the gene in RS and its possible variant including girls with autism or autistic features, developmental stagnancy or regression in girls with unknown etiology, and severe neonatal encephalopathy. XCI pattern will be examined in the family in which the mutation has been detected. We aim to study mutational analysis of the MECP2 gene in other related neurodevelopmental disorder with similar core autistic or neurological regression features, e.g. girls with autism or autistic features, developmental stagnancy or regression girls without unknown etiology, and newborn with unexplained severe encephalopathy and non-syndromal mental retardation. XCI pattern will be examined in family members if mutation is detected. Long term objective: We hope that prenatal test to detect RS families can be available in families with affected daughters (though the risk is < 1%). We hope to test for asymptomatic daughters in RTT families early on (prefebly in stage 1) (< 12 months) such that an early diagnosis can be made or refuted to alleviate parental anxiety. Objective: To detect MECP2 mutation in children with Autistic traits including Rett syndrome, atypical Rett Syndrome, Autism, unexplained mental retardation and infantile epileptic encephalopathy

 

List of Research Outputs

 

Chen W., Wong V.C.N. and Liu W.L., Double Blind Randomized Control Trial of Real Electro-Acupuncture versus Sham Electro-acupuncture in Autism Spectrum Disorder (ASD), 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007.

 

Cheuk D.K.L., Yeung W.F., Chung K.F. and Wong V.C.N., Acupuncture for insomnia (Review), Cochrane Database of Systematic Reviews. 2007, 3: CD005472.

 

Chung B.H.Y. and Wong V.C.N., Clinical markers that enchance etiologic yield in global developmental delay (GDD) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y. and Wong V.C.N., Clinical markers that enhance etiologic yield in global developmental delay, Pediatrics. 2008, 121: S145-S146.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LC1) in Hong Kong: comparison with USA, 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-8 October 2007. 135.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurologic complications (INCs) in children hospitalized with laboratory confirmed influenza (LCI) in Hong Kong: Comparison with USA (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., [Letters to the Editor] Neurologic complications in children hospitalized with influenza: Comparison between USA and Hong Kong, Journal of Pediatrics. 2007, 151(5): e17-e18.

 

Fertleman C.R., Ferrie C.D., Aircardi J., Bednarek N.A., Eeg-Olofsson O., Elmslie F.V., Griesemer D.A., Goutieres F., Kirkpatrick M., Malmros I.N., Pollitzer M., Rossiter M., Roulet-Perez E., Schubert R., Smith V.V., Testard H., Wong V.C.N. and Stephenson J.B., Paroxysmal Extreme Pain Disorder (Previously Familial Rectal Pain Syndrome), Neurology. 2007, 69: 586-595.

 

Fong C.Y., Kwan P., Hui A.C.F., Lui C.H.T., Fong K.Y. and Wong V.C.N., An epidemiological study of epilepsy in Hong Kong SAR, China, Seizure. 2008, 17: 457-464.

 

Fung C.W., Blau N., Siu S., Mak C., Tam S. and Wong V.C.N., A new presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency - Dopa Responsive Dystonia (DRD), Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A new presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency Dopa Responsive Dystonia (DRD), 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C., Poon G.W.K., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly - transaldolase deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Siu S., Mak C.M., Poon G.W.K., Wong K.Y., Cheung P.T., Low L.C.K., Tam S. and Wong V.C.N., A rare cause of hepatosplenomegaly transaldolase deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Cheung P.T., Tam S. and Wong V.C.N., A rare presentation of 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency - Dopa Responsive Dystronia (DRD), A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Cheung P.T., Mak C.M., Siu S., Tam S. and Wong V.C.N., A study of cerebrospinal fluid neurotransmitters assay in children with undiagnosed neurological diseases in Hong Kong, Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society and HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Fung C.W., Blau N., Siu S., Mak C.M., Tam S. and Wong V.C.N., An atypical presentation of cerebral folate deficiency, Annual Symposium of Society for the Study of Inborn Errors of Metabolism, Hamburg, 4-7 September 2007.

 

Kennerknecht I., Wang H., Elze T., Welling B., Wong V.C.N. and Liu J., Evaluation of a powerful screening tool for hereditary prosopagnosia, 40th European Human Genetics Conference, Barcelona, 31 May - 3 June 2008 (Abstract in European Journal of Human Genetics). 2008, 16(suppl 2): 387-88.

 

Kwan P., Baum L., Wong V.C.N., Ng P.W., Lui C.H.T., Sin N.C., Hui A.C.F., Yu E. and Wong L.K.S., Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese, Epilepsy & Behavior. 2007, 11: 112-117.

 

Luk H.M., Chung B.H.Y., Tsang A.M.C. and Wong V.C.N., Influenza-related neurological complications in hospitalized children with laboratory confirmed influenza in Hong Kong: comparison with USA, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Luk H.M., Fung C.W., Mak C.M., Lam C.W., Tam S. and Wong V.C.N., Severe myoclonic epilepsy in infancy (SMEI) or Dravet Syndrome - case report with SCN1A mutation in Hong Kong, 7th Asian Oceanian Epilepsy Congress in Xiamen, China, 15-18 May 2008.

 

Luk H.M., Fung C.W., Mak C.M., Lam C.W., Tam S. and Wong V.C.N., Severe myoclonic epilepsy in infancy (SMEI) or Dravet Syndrome - case report with SCN1A mutation in Hong Kong, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses (organized by The HK Paediatric Society & HK Paediatric Nurses Association), Hong Kong, 27 October, 2007.

 

Martins S., Calafell F., Gaspar C., Wong V.C.N., Silveira I., Nicholson G.A., Brunt E.R., Tranebjaerg L., Stevanin G., Hsieh M., Soong B., Loureiro L., Durr A., Tsuji S., Watanabe M., Jardim L.B., Giunti P., Riess O., Ranum L.P.W., Brice A., Rouleau G.A., Coutinho P., Amorim A. and Sequeiros J., Asian Origin for the Worldwide-Spread Mutational Event in Machado-Joseph Disease, Archive of Neurology. 2007, 64: 1502-1508.

 

Rath B., Linder T., Cornblath D., Hudson M., Fernandopulle R., Hartmann K., Heininger U., Izurieta H., Killion L., Kokotis P., Oleske J., Vajdy M. and Wong V.C.N., All that palsies is not Bell's - the need to define Bell's palsy as an adverse event following immunization, Vaccine. 2007, 26(1): 1-14.

 

Wong C.L. and Wong V.C.N., Any Relationship for Classifying Epilepsy Using Western Medicine versus Traditional Chinese Medicine - A Cross-sectional Study of 40 Children, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Effect of Acupuncture in a Child with Chronic Bell's Palsy, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Pilot Study in the Use of Body Acupuncture in 7 Children with Autism, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Pilot Study of Acupuncture in Children with Chronic Neurological Diseases, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Relationship for Classifying Epilepsy Using Western Medicine vs Traditional Chinese Medicine - A Cross-sectional Study of 40 Cases, 12th Research Postgraduate Symposium, Hong Kong, 12 & 14 December 2007.

 

Wong C.L. and Wong V.C.N., Study of Children with Autism Spectrum Disorders Using Symptom Differentiation of Traditional Chinese Medicine (TCM), 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong C.L. and Wong V.C.N., Use of Acupuncture in Management of Spasticity, 2007 Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, 16 August, 2007.

 

Wong S.S.N., Luk D.C.K., Wong V.C.N., Scheper G.C. and Knaap M.S., Vanishing White Matter Disease: The First Reported Chinese Patient, Journal of Child Neurology. SAGE, 2008, 23(6): 710-714.

 

Wong V.C.N., Acupuncture in Children with Neurological Disorders, Joint Sichuan-Hong Kong Neurology Forum, Jiuzhaigou, Sichuan, China, 23-26 August 2007.

 

Wong V.C.N., Associate Member (Since 1995), American Association of Electrodiagnostic Medicine. 2008.

 

Wong V.C.N. and Hui L.H., Brief Report: emerging services for children with autism spectrum disorders in Hong Kong (1960-2004), Journal of Autism and Developmental Disorders. 2008, 38: 383-389.

 

Wong V.C.N., Chairperson, in "Recent Advances in Children Neurology 2" session, International Symposium Celebrating the 50th Japanese Society of Child Neurology, Tokyo, Japan, 28-30 May 2008. 2008.

 

Wong V.C.N., Chairperson, 第十二届全國小兒神經學術會議 12th National Child Neurology Congress, Wuyishan, Fujien, China (27-29 October, 2007). 2007.

 

Wong V.C.N., Checklist for Autism in Toddlers (CHAT-23) and a Pilot Study on Early Intervention for Autism in Chinese Children, 16th International Conference on Infant Studies, Vancouver, Canada, 27-29 March, 2008.

 

Wong V.C.N., Chief organizer, Autism Awareness Day, Hong Kong, 2 April, 2008. 2008.

 

Wong V.C.N., Co-Chairperson, 2007 Shanghai International Pediatric Neurology & Psychiatry Forum (上海國際兒科神經精神論壇), Shanghai, China, 3-4 November, 2007. 2007.

 

Wong V.C.N., Chen W. and Liu W.L., Double Blind Randomized Control Trial of Acupuncture in Children with Autism Spectrum Disorder, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N. and Wong C.L., Effect of Acupuncture in a Child with Chronic Bell's Palsy, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N. and Hui L.H., Epidemiological study of autism spectrum disorder in China, Journal of Child Neurology. 2008, 23(1): 67-72.

 

Wong V.C.N., Hong Kong Delegate (Since 1987), 2008.

 

Wong V.C.N., Hong Kong Delegate (Since 1987), Asian Oceanean Child Neurology Association. 2008.

 

Wong V.C.N., Honorary Fellow (Since 2003), Hong Kong Society of Rehabilitation Medicine. 2008.

 

Wong V.C.N., Integration of Traditional Chinese Medicine & Western Medicine for Neurodevelopmental Disorders, 2007 Shanghai International Pediatric Neurology & Psychiatry Forum (上海國際兒科神經精神論壇), Shanghai, China, 3-4 November, 2007.

 

Wong V.C.N., Integration of traditional Chinese medicine (acupuncture) with Western medicine for neurohabilitation of children with neurodevelopmental disorders, 1st Asian Oceania Conference of Physical and Rehabilitation Medicine, Nanjing, China, 16-19 May, 2008.

 

Wong V.C.N., Member (Since 1985), Hong Kong Neurological Society. 2008.

 

Wong V.C.N., Member (Since 1996), World Muscle Society. 2008.

 

Wong V.C.N., Member (Since 1997), American Society of Neurorehabilitation. 2008.

 

Wong V.C.N., Member (Since 1997), European Society of Child Neurology. 2008.

 

Wong V.C.N., Member (since 1989), Hong Kong Association for Child & Adolescent Psychilogy & Psychiatry. 2008.

 

Wong V.C.N., Member (since 1997), American Academy of Neurology (Section of Child Neurology). 2008.

 

Wong V.C.N., Member, Editorial Board (since 2001), Pediatric Neurology. 2008.

 

Wong V.C.N., Member, Editorial Board (since 2005), Current Pediatrics Reviews. 2008.

 

Wong V.C.N., Member, Editorial Board, Brain & Development (Since 2003). 2008.

 

Wong V.C.N., Member, Editorial Board, Journal of Child Neurology (Since 2000). 2008.

 

Wong V.C.N., Member, Editorial Board, Journal of Pediatric Neurology (Since 2003). 2008.

 

Wong V.C.N., Member, Editorial Board, Paediatric Rehabilitation (Since 2002). 2007.

 

Wong V.C.N., Member, Editorial Board, Paediatric Rehabilitation (Since 2002). 2008.

 

Wong V.C.N., Member, Editorial Board, Pediatrics International (Since 2001). 2008.

 

Wong V.C.N., Member, Working Group on Global Developmental Delay Initiative, Honolulu, Hawaii, 1-2 May 2008. 2008.

 

Wong V.C.N., Occipital deep white matter hyperintensities in autism spectrum disorder, Pediatrics International. 2007, 49: 513-515.

 

Wong V.C.N., Outstanding Teams award - As co-Team Leader of the Hong Kong West Cluster Paediatric Metabolic Team, Hospital Authority. 2008.

 

Wong V.C.N., Paediatric Neurorehabilitation - the Hong Kong Model, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Wong V.C.N. and Wong C.L., Pilot Study in the Use of Body Acupuncture in 7 Children with Autism Spectrum Disorder, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N., Pilot Study of efficacy of tongue and body acupuncture in children with visual impairment, World Ophthalmology Congress 2008, Hong Kong, 28 June - 2 July 2008.

 

Wong V.C.N., Sun J.G. and Yeung D.W.C., Randomized Control Trial of Using Tongue Acupuncture in Autistic Spectrum Disorder using PET Scan for Clinical Correlation, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N. and Sun J.G., Randomized Control Trial of Using Tongue Acupuncture versus No Acupuncture in Children with Autism Spectrum Disorder, 2007 Annual Conference of the Society for Acupuncture Research, Baltimore, Maryland, USA, 8-11 November, 2007.

 

Wong V.C.N., Response to Correspondence on "Pilot Study of Efficacy of Tongue and Body Acupuncture in Children with Visual Impairment", Journal of Child Neurology. 2008, 23(6): 718-719.

 

Wong V.C.N. and Li Y.H., Rett syndrome: prevalence among Chinese and a comparison of MECP2 mutations of classic Rett syndrome with other neurodevelopmental disorders, Journal of Child Neurology. 2007, 22(12): 1397-1400.

 

Wong V.C.N., Reviewer (Since 1990), Clinical Drug Investigation. 2008.

 

Wong V.C.N., Reviewer (since 1987), Hong Kong Medical Journal. 2008.

 

Wong V.C.N., Reviewer (since 1990), Hong Kong Journal of Paediatrics. 2008.

 

Wong V.C.N., Reviewer (since 2005), Lancet. 2008.

 

Wong V.C.N., Reviewer (since 2005), New England Journal of Medicine. 2008.

 

Wong V.C.N., Reviewer (since 2006), Archives of Pediatrics & Adolescent Medicine. 2008.

 

Wong V.C.N., Reviewer (since 2007), Epileptic Disorders. 2008.

 

Wong V.C.N., Reviewer (since 2007), Infection. 2008.

 

Wong V.C.N., Reviewer (since 2007), Neuropediatrics. 2008.

 

Wong V.C.N., Reviewer (since 2007), Pediatric Rehabilitation/Developmental Neurorehabilitation. 2008.

 

Wong V.C.N., Reviewer (since 2007), The Lancet Neurology. 2008.

 

Wong V.C.N., Reviewer (since 2007), The Open Pediatric Medical Journal. 2008.

 

Wong V.C.N., Reviewer (since 2008), Autism Research. 2008.

 

Wong V.C.N., Reviewer (since 2008), International Journal of Developmental Neuroscience. 2008.

 

Wong V.C.N., Reviewer (since 2008), Journal of Autism and Developmental Disorders. 2008.

 

Wong V.C.N., Reviewer (since 2008), Journal of Zhejiang University - SCIENCE "B". 2008.

 

Wong V.C.N., Reviewer (since 2008), Neurology India. 2008.

 

Wong V.C.N., Reviewer (since 2008), Yonsei Medical Journal. 2008.

 

Wong V.C.N., Reviewer, American Journal of Epidemiology (Since 2004). 2008.

 

Wong V.C.N., Reviewer, BMJ Pediatrics (Since 2003). 2008.

 

Wong V.C.N., Reviewer, Brain & Development (Since 1987). 2008.

 

Wong V.C.N., Reviewer, Child: Care, Health and Development (Since 2003). 2008.

 

Wong V.C.N., Reviewer, Developmental Medicine and Child Neurology (Since 2003). 2008.

 

Wong V.C.N., Reviewer, Epilepsia (Since 2003). 2008.

 

Wong V.C.N., Reviewer, European Journal of Paediatric Neurology (Since 2003). 2008.

 

Wong V.C.N., Reviewer, Hong Kong Medical Journal (Since 1987). 2007.

 

Wong V.C.N., Reviewer, Journal of Pediatric Neurology (Since 2000). 2008.

 

Wong V.C.N., Reviewer, Medical Progress (Since 2000). 2008.

 

Wong V.C.N., Reviewer, Medical Science Monitor (Since 2003). 2008.

 

Wong V.C.N., Reviewer, Pediatrics (Since 2000). 2008.

 

Wong V.C.N., Reviwer (since 2003), Journal of Paediatrics, Obstetrics & Gynaceology (JPOG). 2008.

 

Yam W.K.L., Ronen G.M., Cherk S.W.W., Rosenbaum P., Chan K.Y., Streiner D.L., Cheng S.W.W., Fung C.W., Ho J.C.S., Kwong K.L., Ma L.C.K., Ma D.K.H., Tsui K.W., Wong V.C.N. and Wong T.Y.L., Health-related quality of life of children with epilepsy in Hong Kong: How does it compare with that of youth with epilepsy in Canada?, Epilepsy & Behavior. 2008, 12: 419-426.

 

Yung A.W.Y., Fung C.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Wong WHS

List of Research Outputs

 

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Peiris J.S.M. and Lau Y.L., Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS, Health Symposium 2007, 29th September, 2007, Hong Kong. 2007.

 

Chu S.F., Tam C.M., Wong W.H.S., Kam K.M., Lau Y.L. and Chiang A.K.S., Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese, Genes and Immunity. Nature, 2007, 8: 475-479.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK) (poster presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Wong W.H.S. and Lau Y.L., Contribution of birth defects (BDs) and genetic diseases (GDs) to paediatric hospitalization in Hong Kong (HK), The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Dong J., Lee T.L., Lee P.P.W., Ho M.H.K., Wong W.H.S. and Lau Y.L., Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 143.

 

Ho M.H.K., Wong W.H.S., Heine R.G., Hosking C.S., Hill D.J. and Allen K.J., Early clinical predictors of remission of peanut allergy in children, Journal of Allergy Clinical Immunology. 2008, 121: 731-736.

 

Ho M.H.K., Wong W.H.S., Heine R.G., Hosking C.S., Hill D.J. and Allen K.J., Reply - How predictive are predictors of remission of peanut allergy?, Journal of Allergy Clinical Immunology. 2008, 121(6): 1517-1518.

 

Lau Y.L., Dong J., Lee T.L., Lee P.P.W., Ho M.H.K. and Wong W.H.S., Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus, Pediatrics. 2008, 121: S161-2.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 142.

 

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Recurrent major infections in juvenile-onset systemic lupus erythematosus: A close link with long-term disease damage, Pediatrics. 2008, 121 (Suppl 2): S162.

 

Low L.C.K., Wong W.H.S., Lam B.C.C., Sheng H.P. and Wong W., Role of nutritional intake and total energy expenditure on growth of babies born with intrauterine growth retardation, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007. 2007-8-30, 59.

 

Mok P.W.K., Wong W.H.S., Lee P.W.H. and Low L.C.K., Is Teenage Obesity Associated with Depression and Low Self-Esteem?: A Pilot Study, Hong Kong Journal of Paediatrics. 2008, 13: 30-38.

 

Siu H.O., Yang W., Lau C.S., Chan T.M., Wong R.W.S., Wong W.H.S. and Lau Y.L., Association of a Haploytpe of IRF5 Gene with Systemic Lupus Erythematosus in Chinese, Journal of Rheumatology. 2008, 35(2): 360-362.

 

Researcher : Xu X

List of Research Outputs

 

Xu X., Chan K.H. and Chiang A.K.S., Development of Latent and Lytic Epstein-barr Virus (EBV)-specific CD8+ Cytotoxic Lymphocyte Responses in Primary EBV Infection, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14, 158.

 

Researcher : Yang LH

List of Research Outputs

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H. and Lau A.S.Y., Application of Genomics and cell signaling technologies to investigate traditional Chinese medicine: Panex Ginseng and its immunomodulatory effects, NHClaims 2007 Congress, Naantali, Finland, November 7-9. 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray and Gas Chromatography-Mass Spectrometry Technologies to Investigate the Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China, 2007.

 

Lee D.C.W., Chik S.C.C., Li C.B., Yang L.H., Rong J., Tam P.K.H. and Lau A.S.Y., Application of Platform Technologies to Investigate the Immunomodulatory Effects of Ginseng, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November 2007.

 

Lee D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Tam P.K.H. and Lau A.S.Y., Application of platform technologies to investigate the immunomodulatory effects of Ginseng, 4th International Think Tank Forum, Faculty of Medicine, The University of Hong Kong, November 14-16. 2007.

 

Researcher : Yang M

List of Research Outputs

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J.Y., Lau Y.L. and Yang M., Effects of Serotonin on Proplatelet Formation and F-actin Reorganization in Human Megakaryocytes, 49th ASH Annual Meeting, Atlanta, Georgia, USA, 8-11 December 2007 (Abstract in Blood - Journal of the American Society of Hematology). 2007, 110(10): 628a.

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J., Lau A.S.Y. and Yang M., Effects of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes. , Blood 2007. 2007, 118(11):628a.

 

Mo S., Yu J. and Yang M., Comparison Of The Effect Of Angelica Polysaccharide, Platelet-derived Growth Factor And Thrombopoietin On Megakaryocytopoiesis, Zhonghua Er Ke Za Zhi. 2008, 46(1): 45-48.

 

Yang M., Advances In Tpo Research, 2007 Annual Meeting Of Chinese Society For Experimental Hematology. 2007.

 

Yang M., Editorial Board Member (2000-2003, 2004-2007,2008-2012), Journal Of Experimental Hematology--the Official Journal Of Chinese Society For Experimental Hematology. . 2007.

 

Yang M., Editorial Board Member (2004-), "chinese Journal Of Thromb & Haemostasis" --the Official Journal Of Chinese Society For Thromb & Haemostasis.. 2007.

 

Yang M., Editorial Board Member (2005-), "chinese Journal Of Pediatric Hematology And Oncology".. 2007.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Yang M., Stem Cell Research And Its Application, 2007 Annual Meeting Of National Pediatric Hematology And Oncology. 2007.

 

Yang M., The New Role Of Tpo And Its Regulation, Jinan University. 2007.

 

Yang M., Ng M.H., Li C.K., Chan P.K., Liu C., Ye J. and Chong B.H., Thrombopoietin Levels Increased In Patients With Severe Acute Respiratory Syndrome. , Thrombosis Research. 2008, 122: 473-7.

 

Yang M., Thrombopoietin, 2007 Annual Meeting Of Chinese Society For Thrombosis And Haemostasis. 2007.

 

夏 文.杰., 項 鵬. and Yang M., 血小板生成素thrombopoietin對神經保護作用的體外研究, 熱帶醫學雜志, 2007, 7: 05－09.

 

Researcher : Yang W

Project Title:

Linkage Analysis of Spondylo-Metaphyseal Dysplasia(SMD) using Pedigrees in Hong Kong

Investigator(s):

Yang W

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

12/2006

 

Abstract:

Small family cases of SMD "Corner Fracture" type have been reported around the world, but the genetic mutation and the linked genomic region have never been identified. A large pedigree for this disease and 5 smaller families have been collected in Hong Kong. The size of the large pedigree collected contains 14 informative individuals, sufficient to allow us to locate the genomic region containing the mutation for this disease for the first time using linkage analysis method (see Analysis of Human Genetic Linkage, 3rd edition, by Jurg Ott).

 

List of Research Outputs

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 (Transforming Growth Factor-Beta Receptor 2) mutations in Chinese with Marfan syndrome (MFS) and related phenotypes using denaturing high performance liquid chromatography (DHPLC) (oral presentation), 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel TGFBR2 mutations in Chinese with marfan syndrome (MFS) and related phenotypes using DHPLC, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 123.

 

Chung B.H.Y., Li Y.H., Lam S.T.S., Yang W., Lun K.S. and Lau Y.L., Identification of 7 novel transforming growth factor2 receptor 2 mutations in Chinese patients with marfan syndrome, Pediatrics. 2008, 121: s116.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Lee P.P.W., Chen T.X., Yang W., Jiang L.P., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-Linked Agammaglobulinemia, The 4th Congress of Asian Society for Pediatric Research (ASPR), Honolulu, Hawaii, USA (3-6 May 2008). 2008, 78.

 

Lee P.P.W., Chen T.X., Jiang L.P., Chan K.W., Yang W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lee P.P.W., Chen T.X., Jiang L.P., Yang W., Chan K.W., Fok S.F.S., Lee T.L. and Lau Y.L., Clinical, Immunological and Molecular Characteristics of 67 Chinese Patients with X-linked Agammaglobulinemia (Young Investigator Award) , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. Awarding body: Asian Society for Pediatric Research. 2008.

 

Lee P.P.W., Chung B.H.Y., Chan S.Y., Yang W. and Lau Y.L., Teaching and Learning Medical Genetics – An Interactive Genetics Workshop for Pediatric Clerkship Students , Pediatric Academic Societies and Asian Society for Pediatric Research 2008 Joint Meeting, May 3-6 2008. . 2008.

 

Lin G., Wang Z., Wang L., Lau Y.L. and Yang W., Identification Of Linked Regions Using High-density Snp Genotype Data In Linkage Analysis, Bioinformatics. Oxford press, 2008, 24(1): 86-93.

 

Ng P., Yang W. and Lau Y.L., Systemic Lupus Erythematosus In Hong Kong Chinese, 12th Research Postgraduate Symposium, Hong Kong, 11 Dec, 2007.

 

Siu H.O., Yang W., Lau C.S., Chan T.M., Wong R.W.S., Wong W.H.S. and Lau Y.L., Association of a Haploytpe of IRF5 Gene with Systemic Lupus Erythematosus in Chinese, Journal of Rheumatology. 2008, 35(2): 360-362.

 

Willcocks L.C., Lyons P.A., Clatworthy M.R., Robinson J.I., Yang W., Lau Y.L. and Smith K.G.C., 8. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake, Journal of Experimental Medicine. 2008, 10.1084/jem.20072413: 1-9.

 

Yang W., Huang P., Zhao M. and Lau Y.L., Biomarker Identification For Early Tumor Detection Aided By Bioinformatics Gene Expression Analysis, The International Conference On Biomedical Engineering And Informatics (bmei2008), Sanya, Hainan, China. 2008.

 

Yang W., Zhao M. and Lau Y.L., Biomarker Identification for Early Tumor Detection Aided by Bioinformatics Gene Expression Analysis, 2008 International Conference on BioMedical Engineering and Informatics. 2008, 1: 469-473.

 

Yang W., Sham P.C., Wang Z., Wang L., Huang P. and Lau Y.L., Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies , European Journal of Human Genetics. 2008, doi:10.1038/ejhg.2008.116: 1-9.

 

Yang W., Wang Z., Wang L., Huang P. and Lau Y.L., Prediction of the linked regions and exclusion probabilities -- requirement on family sizes in linkage analyses , 57th annual meeting of the american society of human genetics, Oct 23-27, 2007, SanDiego, USA . 2007.

 

Yu F., Chen M.H., Kuo L. and Yang W., A New Multilevel Nonlinear Mixture Dirichlet Model For Expressed Sequence Tag Data, Conference On Emerging Design And Analysis Issues In Genomic Studies In Population Sciences, Harvard Medical School, Oct 11-12, 2007. Harvard Medical School.

 

Researcher : Ye J

List of Research Outputs

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J., Lau A.S.Y. and Yang M., Effects of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes. , Blood 2007. 2007, 118(11):628a.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Yang M., Ng M.H., Li C.K., Chan P.K., Liu C., Ye J. and Chong B.H., Thrombopoietin Levels Increased In Patients With Severe Acute Respiratory Syndrome. , Thrombosis Research. 2008, 122: 473-7.

 

Researcher : Ye J

List of Research Outputs

 

Cheng Y.S., Liu Y.S., Chan G.C.F., Ye J., Lau A.S.Y. and Yang M., Effects of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes. , Blood 2007. 2007, 118(11):628a.

 

Yang M., Zhou M., Cheung Y.F., Ye J., Chan S. and Chan G.C.F., Effect Of Melatonin On Iron-induced Apoptosis In Megakaryocytic Cells , 15th International Vascular Biology Meeting. 2008, 2008: P321.

 

Yang M., Ng M.H., Li C.K., Chan P.K., Liu C., Ye J. and Chong B.H., Thrombopoietin Levels Increased In Patients With Severe Acute Respiratory Syndrome. , Thrombosis Research. 2008, 122: 473-7.

 

Researcher : Yick LW

Project Title:

Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation

Investigator(s):

Yick LW, Chan SY

Department:

Paediatrics & Adolescent Med

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To understand the role of EGF in chondrocyte differentiation using our 'knock-in mice' with targeted expression of EGF in prehypertrophic chondrocytes.

 

 

Researcher : Yim HCH

List of Research Outputs

 

Cheung B.K.W., Chan L.L.Y., Yim H.C.H., Chan M.P., Li C.B., Lee D.C.W. and Lau A.S.Y., Immunotherapy of mycobacterial infections: a cell and molecular model, Health Research Symposium 2007, Hong Kong Academy of Medicine, September 29. 2007.

 

Li C.B., Yim H.C.H., Lee D.C.W. and Lau A.S.Y., Best Abstract Award at the Annual Scientific Meeting and General Meeting 2008, Hong Kong Society for Immunology. 2008.

 

Li C.B., Yim H.C.H. and Lau A.S.Y., Cellualr Signaling Events In Cytokines And Sulphamethoxasole Interactions, The First Scientific Meeting And The Second Annual General Meeting, The Hong Kong Society For Paediatric Immunology And Infectious Diseases . 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Li C.B., Lee D.C.W., Yim H.C.H. and Lau A.S.Y., Mechanism of HIV Tat-regulated immune response and cytokine dysregulation, Annual Scientific Meeting and General Meeting of Hong Kong Society for Immunology 2008 . 2008.

 

Li C.B., Yim H.C.H. and Lau A.S.Y., Runner-up Oral Presentation Award At The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases, The Hong Kong Society For Paediatric Immunology And Infectious Diseases. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Best Oral Presentation Award, The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases, The Hong Kong Society For Paediatric Immunology And Infectious Diseases. 2008.. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., Cellular signaling events in cytokines and sulphamethoxasole interactions, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 Tat Plays a Role in Dysregulating Lipopolysaccharide-Induced Cytokine Expression: Implications for Immune Defects in Aids, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 15 March. 2008.

 

Yim H.C.H., Li C.B., Lau A.S.Y. and Lee D.C.W., HIV-1 Tat plays a role in dysregulating lipopolysaccharide-induced cytokine expression: implications for immune defects in AIDS, 1st Annual Scientific Meeting & 2nd Annual General Meeting, Hong Kong Society for Paediatric Immunology and Infectious Diseases, 17 May 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune response induced by lipopolysaccharides, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, Hong Kong, 19 April. 2008.

 

Yim H.C.H., Li C.B. and Lau A.S.Y., HIV-1 regulation of immune responses induced by lipopolysaccharides, 2008 Annual General Meeting and Scientific Meeting, Hong Kong Society for Immunology, 19 April 2008.

 

Researcher : Yip MS

List of Research Outputs

 

Yip M.S., Law H.K.W., Tu W. and Lau Y.L., Immune responses of human respiratory epithelia cells to human metapneumovirus and respiratory syncytial virus. IMMUNORIO 2007, 13th International Congress of Immunology, Rio de Janeiro-Brazil, 21-25 August 2007.

 

Researcher : Yung AWY

List of Research Outputs

 

Chee Y.Y., Yung A.W.Y. and Tsang A.M.C., Review of do-not-resusciate orders in paediatric patients, A Joint Annual Scientific Meeting for Paediatricians and Paediatric Nurses, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd., Hong Kong, 27 October 2007. 41.

 

Yung A.W.Y., Fung C.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Yung A.W.Y., Hung K.N., Khong P.L., Ho W.Y., Fung C.W., Leung C.S.Y., Fan Y.W. and Wong V.C.N., Comprehensive Paediatric Epilepsy Program in Hong Kong West Cluster: Queen Mary Hospital/Duchess of Kent Children's Hospital - Development of Paediatric Epilepsy Surgery Program 1997-2007, 12th National Child Neurology Congress (第十二届全國小兒神經學術會議), Wuyishan, China, 27-29 October, 2007.

 

Researcher : Yung TC

List of Research Outputs

 

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation, International Journal of Cardiology. 2008, 127: 192-197.

 

Koh C., Yung T.C., Lun K.S. and Cheung Y.F., Left Ventricular Noncompaction in Children, 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008. 2008.

 

Koo S.D., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Cardiovascular symptoms and signs in evaluating cardiac murmurs in children, Pediatrics International. 2008, 50: 145-149.

 

Researcher : Zhao M

List of Research Outputs

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Yang W., Huang P., Zhao M. and Lau Y.L., Biomarker Identification For Early Tumor Detection Aided By Bioinformatics Gene Expression Analysis, The International Conference On Biomedical Engineering And Informatics (bmei2008), Sanya, Hainan, China. 2008.

 

Yang W., Zhao M. and Lau Y.L., Biomarker Identification for Early Tumor Detection Aided by Bioinformatics Gene Expression Analysis, 2008 International Conference on BioMedical Engineering and Informatics. 2008, 1: 469-473.

 

Researcher : Zhao M

List of Research Outputs

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, ACGA-HKSMG International Conference on Genetic and Genomic Medicine, HK, 8-11 June 2008. 105.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese Family, Association of Chinese Geneticists in America – Hong Kong Society of Medical Genetics International Conference on Genetic and Genomic Medicine, Hong Kong, 8-11 June, 2008.

 

Chung B.H.Y., Fung C.W., Ng P., Zhao M., Yang W. and Wong V.C.N., Infantile convulsion choreoathetosis syndrome in a Hong Kong Chinese family, 7th & Oceanian Epilepsy Congress, Xiamen International Conference and Exhibition Centre, Xiamen, PR China, 15-18 May 2008.

 

Yang W., Huang P., Zhao M. and Lau Y.L., Biomarker Identification For Early Tumor Detection Aided By Bioinformatics Gene Expression Analysis, The International Conference On Biomedical Engineering And Informatics (bmei2008), Sanya, Hainan, China. 2008.

 

Yang W., Zhao M. and Lau Y.L., Biomarker Identification for Early Tumor Detection Aided by Bioinformatics Gene Expression Analysis, 2008 International Conference on BioMedical Engineering and Informatics. 2008, 1: 469-473.

 

Researcher : Zheng J

List of Research Outputs

 

Mao H., Tu W., Qin G., Chan P.L., Law H.K.W., Zheng J., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Enhanced activation and cytotoxicity of natural killer cells by influenza H5N1 virus-infected macrophages, Hong Kong Society for Immunology 2008 Annual General Meeting and Scientific Meeting, 19th April, 2008, HKSAR. 2008, 38.

 

Researcher : Zhou J

List of Research Outputs

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.

 

Researcher : Zhou J

List of Research Outputs

 

Mao H., Zhou J., Tu W., Law H.K.W. and Lau Y.L., Anti-viral activities of mannose binding lectin against avian influenza virus, 25th International Congress of Pediatrics, Athens, Greece, 25-30 August 2007 (oral presentation). 2007.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential expressions of cytokines and chemokines in macrophages infected with 483/97 and 1203/04 H5N1 viruses, The 3rd Congress of Asian Society for Pediatric Research, Tokyo, Japan, 6-9 October 2007. 104.

 

Mao H., Zhou J., Tu W., Law H.K.W., Cheung C.Y., Sia S.F., Peiris J.S.M. and Lau Y.L., Differential proinflammatory responses in macrophages infected with 483/97 and 1203/04 H5N1 viruses, 12nd Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 12-14 December, 2007. 114.



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