DEPT OF MEDICINE
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Researcher
: Au KW |
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List of Research Outputs |
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Au K.W., Siu D.C.W., Lau C.P., Tse H.F. and Li R.A., Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions, American Journal of Physiology Cellular Physiology . 2007, 294(1): C136-144. |
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Siu D.C.W., Au K.W., Lau C.P., Tse H.F. and Li R.A., Dynamic Conformational changes of the P-S6 linker of the packemakers (HCN) Channels identified by sulfhydryl modification: Port-to-gate coupling model , Heart Rhythm . 2008, 5, No. 5 May Supplement. |
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List of Research Outputs |
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Au
W.Y., Lam W.M., |
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Au
W.Y., Lam W.W., |
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Au
W.Y., Lam W.W., |
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Au
W.Y., Lam W.W.M., |
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Au W.Y. and Kwong Y.L., Arsenic trioxide: safety issues and their management, Acta Pharmacologica Sinica. 2008, 29(3): 296-304. |
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Au W.Y., Lo S.H., Law W.L., Khong P.L., Shek T.W.H., Lau W.H. and Chan E.M.C., Concomitant EBER+ve lymphomatoid papulosis and malignant transformation of colonic polyposis in a heart transplant recipient, Journal of Heart and Lung Transplantation. 2008, 27: 575-576. |
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Au W.Y., Tam S. and Kwong Y.L., Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment , Leukemia Research. 2007, 32(2): 357-358. |
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Au W.Y., Leung R.Y.Y., Mok T., Fung T.K. and Liang R.H.S., Familial occurrence of sequential B-cell lymphoma and myeloproliferative disease , Annals of Hematology. 2008, Epub. |
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Au W.Y., Pang A.W.K., Lam K.Y., Song Y., Lam W.M., So J.C.C. and Kwong Y.L., G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors, Bone Marrow Transplantation. 2007, 40(7): 677-681. |
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Au W.Y., Chan E. and Lie A.K.W., Hemopoietic stem cell transplantation from a donor with indeterminate HTLV-1 status, American Journal of Hematology. 2007, 82(6): 495. |
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Au W.Y., Leung A.Y.H., Tse E.W.C., Cheung W.W., Shek T.W.H. and Kwong Y.L., High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients, Leukemia Research. 2007, 32(4): 547-551. |
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Au W.Y., Liu C.L., Tam S., Fong B.M., Shek T.W.H., Hui C.K. and Kwong Y.L., Oral arsenic trioxide therapy for acute promyelocytic leukemia before and after liver transplantation for hepatitis B virus-related liver failure, Annals of Hematology. 2007, 86(10): 771-2. |
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Au W.Y., Yeung C.K., Cheung M.C. and Trendell-Smith N.J., Penile lichen sclerosus after allogeneic stem cell transplantation, British Journal of Dermatology. EPub, 2008. |
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Au W.Y., Tam S., Fong B.M., Ho K.L., Tam P.C. and Kwong Y.L., Prolonged oral arsenic trioxide therapy and neprholithiasis, Leukemia and Lymphoma . 2007, 48(11): 2233-2234. |
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Au W.Y., Relevance of drug allergy history after allogeneic hemopoietic stem cell transplantation, Bone Marrow Transplantation. 2007, 40(2): 179-180. |
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Au W.Y., Tam S., Fong B.M., Wan T.S.K., Yip S.F. and Kwong Y.L., Second hematological malignancies during arsenic trioxide therapy of B-cell lymphomas , Leukemia Research. EPub, 2008. |
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Au W.Y., Lie A.K.W., Cheng V.C.C., Cheng L.C., Wang E.P. and Wong C.F., Successful Lung Transplantation for Post-BMT Bronchiolitis Obliterans and Lipoid Pneumonia Associated with Atypical Mycobacterium and Aspergillosis Infection , The Journal of Heart and Lung Transplantation. 2007, 26(8): 870-872. |
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Au
W.Y. and Liang
R.H.S., Thalassaemia management in |
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Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Wong H.M., Very late relapse of B cell lymphoma masquerading as blastic transformation of chronic myeloid leukemia, Leuk Lymphoma. 2007, 48(7): 1414-1416. |
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Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology. 2008, 13(4): 322-330. |
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Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology (Carlton). 2008, 13(4): 322-30. |
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Chan
G.S.W., Lam M.F., Au W.Y.,
Tse K.C., Chim S., Fung S.H., Lo
S.H.K., Lai K.N. and Chan K.W., Renal Pathology after
Haematopoietic Stem Cell Transplantation (HSCT): A study of 13 patients, 24th
World Congress of Pathology and Laboratory Medicine, 20-24 August 2007, |
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Chan K.K., Shen L., Guo T., Wong M.L.Y., Wong K.Y., Au W.Y., Lu L., Kwong Y.L., Liang R.H.S. and Srivastava G., IL2 induced NF-kB activation in nasal NK/T-cell lymphoma is mediated through Akt and BCL10, Keystone Symposia on Molecular and Cellular Biology: Lymphocyte Activation and Signaling, February 3-8, 2008, Snowbird Resort, Snowbird, Utah. 2008. |
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Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46. |
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He T., Kirk P., Firmin D.N., Lam W.M., |
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Hui C.K., Cheung W.W., Leung K.W., Cheng V.C.C., Tang S.F., Li W.S., Lee N.P., Kwong Y.L., Au W.Y., Yuen K.Y., Lau G. and Liang R.H.S., Outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen, Hepatology. EPub, 2008. |
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Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
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Hwang Y.Y., Fan K., Lam Y.M., Chan W.S., Cheung S.C.W., Wang E.P. and Au W.Y., Primary cardiac lymphoma presenting with right heart mass and bradycardia, Annals of Hematology. 2007, 86(9): 685-6. |
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Khong
P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18
fluorodeoxyglucose positron emission tomography in mature T-cell and antural
killer cell malignancies, 10th International Conference on Malignant
Lymphoma, |
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Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21. |
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Lam W.W., Au W.Y., |
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Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. |
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Shen L., Au W.Y., Guo T., Wong K.Y., Wong M.L.Y., Tsuchiyama J., Yuen P.W., Kwong Y.L., Liang R.H.S. and Srivastava G., Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: an in vitro and in vivo preclinical evaluation, Blood. 2007, 110(1): 469-70. |
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Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
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List of Research Outputs |
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Au
W.Y., Lam W.M., |
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Au
W.Y., Lam W.W., |
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Au
W.Y., Lam W.W., |
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Au
W.Y., Lam W.W.M., |
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Au W.Y. and Kwong Y.L., Arsenic trioxide: safety issues and their management, Acta Pharmacologica Sinica. 2008, 29(3): 296-304. |
|
Au W.Y., Lo S.H., Law W.L., Khong P.L., Shek T.W.H., Lau W.H. and Chan E.M.C., Concomitant EBER+ve lymphomatoid papulosis and malignant transformation of colonic polyposis in a heart transplant recipient, Journal of Heart and Lung Transplantation. 2008, 27: 575-576. |
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Au W.Y., Tam S. and Kwong Y.L., Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment , Leukemia Research. 2007, 32(2): 357-358. |
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Au W.Y., Leung R.Y.Y., Mok T., Fung T.K. and Liang R.H.S., Familial occurrence of sequential B-cell lymphoma and myeloproliferative disease , Annals of Hematology. 2008, Epub. |
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Au W.Y., Pang A.W.K., Lam K.Y., Song Y., Lam W.M., So J.C.C. and Kwong Y.L., G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors, Bone Marrow Transplantation. 2007, 40(7): 677-681. |
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Au W.Y., Chan E. and Lie A.K.W., Hemopoietic stem cell transplantation from a donor with indeterminate HTLV-1 status, American Journal of Hematology. 2007, 82(6): 495. |
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Au W.Y., Leung A.Y.H., Tse E.W.C., Cheung W.W., Shek T.W.H. and Kwong Y.L., High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients, Leukemia Research. 2007, 32(4): 547-551. |
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Au W.Y., Liu C.L., Tam S., Fong B.M., Shek T.W.H., Hui C.K. and Kwong Y.L., Oral arsenic trioxide therapy for acute promyelocytic leukemia before and after liver transplantation for hepatitis B virus-related liver failure, Annals of Hematology. 2007, 86(10): 771-2. |
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Au W.Y., Yeung C.K., Cheung M.C. and Trendell-Smith N.J., Penile lichen sclerosus after allogeneic stem cell transplantation, British Journal of Dermatology. EPub, 2008. |
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Au W.Y., Tam S., Fong B.M., Ho K.L., Tam P.C. and Kwong Y.L., Prolonged oral arsenic trioxide therapy and neprholithiasis, Leukemia and Lymphoma . 2007, 48(11): 2233-2234. |
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Au W.Y., Relevance of drug allergy history after allogeneic hemopoietic stem cell transplantation, Bone Marrow Transplantation. 2007, 40(2): 179-180. |
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Au W.Y., Tam S., Fong B.M., Wan T.S.K., Yip S.F. and Kwong Y.L., Second hematological malignancies during arsenic trioxide therapy of B-cell lymphomas , Leukemia Research. EPub, 2008. |
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Au W.Y., Lie A.K.W., Cheng V.C.C., Cheng L.C., Wang E.P. and Wong C.F., Successful Lung Transplantation for Post-BMT Bronchiolitis Obliterans and Lipoid Pneumonia Associated with Atypical Mycobacterium and Aspergillosis Infection , The Journal of Heart and Lung Transplantation. 2007, 26(8): 870-872. |
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Au
W.Y. and Liang
R.H.S., Thalassaemia management in |
|
Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Wong H.M., Very late relapse of B cell lymphoma masquerading as blastic transformation of chronic myeloid leukemia, Leuk Lymphoma. 2007, 48(7): 1414-1416. |
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Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology. 2008, 13(4): 322-330. |
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Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology (Carlton). 2008, 13(4): 322-30. |
|
Chan
G.S.W., Lam M.F., Au W.Y.,
Tse K.C., Chim S., Fung S.H., Lo
S.H.K., Lai K.N. and Chan K.W., Renal Pathology after
Haematopoietic Stem Cell Transplantation (HSCT): A study of 13 patients, 24th
World Congress of Pathology and Laboratory Medicine, 20-24 August 2007, |
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Chan K.K., Shen L., Guo T., Wong M.L.Y., Wong K.Y., Au W.Y., Lu L., Kwong Y.L., Liang R.H.S. and Srivastava G., IL2 induced NF-kB activation in nasal NK/T-cell lymphoma is mediated through Akt and BCL10, Keystone Symposia on Molecular and Cellular Biology: Lymphocyte Activation and Signaling, February 3-8, 2008, Snowbird Resort, Snowbird, Utah. 2008. |
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Cheuk D.K.L., Au W.Y., Ho M.H.K., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Neutropenia and Agranulocytosis Associated with the Use of Deferiprone in Patients with Thalassemia Major: The Expeerience of Queen Mary Hospital in Hong Kong, 17th International Conference on Chelation (ICOC) for the treatment of thalassaemia, cancer and other diseases related to metal and free radical imbalance and toxicity, Shenzhen, PR China, 23-26 November 2007. 46. |
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He T., Kirk P., Firmin D.N., Lam W.M., |
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Hui C.K., Cheung W.W., Leung K.W., Cheng V.C.C., Tang S.F., Li W.S., Lee N.P., Kwong Y.L., Au W.Y., Yuen K.Y., Lau G. and Liang R.H.S., Outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen, Hepatology. EPub, 2008. |
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Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
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Hwang Y.Y., Fan K., Lam Y.M., Chan W.S., Cheung S.C.W., Wang E.P. and Au W.Y., Primary cardiac lymphoma presenting with right heart mass and bradycardia, Annals of Hematology. 2007, 86(9): 685-6. |
|
Khong
P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18
fluorodeoxyglucose positron emission tomography in mature T-cell and antural
killer cell malignancies, 10th International Conference on Malignant
Lymphoma, |
|
Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21. |
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Lam W.W., Au W.Y., |
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Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. |
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Shen L., Au W.Y., Guo T., Wong K.Y., Wong M.L.Y., Tsuchiyama J., Yuen P.W., Kwong Y.L., Liang R.H.S. and Srivastava G., Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: an in vitro and in vivo preclinical evaluation, Blood. 2007, 110(1): 469-70. |
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Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
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Researcher
: Chan AOO |
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List of Research Outputs |
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Chan
A.O.O., Jim
M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
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Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
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Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
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Yee Y.K., Cheung T.K., Chan A.O.O., Yuen R.M.F. and Wong B.C.Y., Decreasing Trend Of
Esophageal Adenocarcinoma In |
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Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
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Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
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Researcher
: Chan BYY |
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List of Research Outputs |
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Chan B.Y.Y., Lau K.S., Jiang B., Kennelly E.J., Kronenberg F. and Kung A.W.C., Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells, BONE. 2008. |
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Researcher
: Chan C |
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List of Research Outputs |
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Shum D.K.Y., Chan C., Liu H.Y., Chau C.H. and Chan Y.S., Addressing the pericellular matrix of reactive astrocytes. , Abstracts of Croucher Advanced Study Institute: Innovative Therapies of Movement Disorders, D12. HK. Nov. 27-30. 2007. |
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Researcher
: Chan CF |
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List of Research Outputs |
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Chan C.F., Leung A.Y.H., Chan Y.S. and Cheung R.T.F., Central administration of granulocyte- colony stimulating factor in a mice middle cerebral artery occlusion stroke model reduces infarct volume and improves functional outcome, Soc. Neuroscience Abstract (U.S.A.): 598.1. 2007. |
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Researcher
: Chan CK |
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List of Research Outputs |
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Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
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Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
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Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
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Researcher
: Chan DTM |
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Project Title: |
Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells |
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Investigator(s): |
Chan DTM, Yung SSY |
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Department: |
Medicine |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
11/2003 |
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Abstract: |
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To characterize HMC membrane and intracellular molecules responsible for binding to anti-DNA antibodies-by trypsin, papain, or pepsin digestion, Western blotting, and protein sequencing; to examine the relationship between the properties of human anti-dsDNA antibodies (isoelectric point, binding to HMC, cellular internalization), their correlation with clinical disease activity, and their effects on cell function, morphology, proliferation, and apoptosis; to elucidate the mechanisms by which anti-dsDNA antibodies bind and penetrate plasma membrane, traverse the cytoplasm, and enter the nucleus of HMC. This will be achieved by kinetic studies using timed flow cytometry, immunohistochemistry, and confocal microscopy. The latter will also be used to investigate the binding between anti-dsDNA antibodies and cytoskeletal structures including myosin. The effects of anti-dsDNA antibodies in the presence or absence of DNA and histones on the synthesis of cytoskeletal molecules will be examined by radiolabelling and immunoprecipitation. |
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Project Title: |
Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis |
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Investigator(s): |
Chan DTM, Yung SSY |
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Department: |
Medicine |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
12/2004 |
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Abstract: |
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To assess the clinical effects of mycophenolate mofetil (MMF) and cyclophosphamide on disease manifestations in MRL/1pr mice with lupus nephritis; to determine the effects of MMF and cyclophosphamide on serum levels of anti-DNA antibodies, pro-inflammatory mediators, and markers of fibrosis; to examine the effects of MMF and cyclophosphamide on kidney histopathology in MRL/1pr mice with lupus nephritis, focusing on mesangial cell proliferation, synthesis of inflammatory/fibrosis mediators, and production of matrix components. The data will be analyzed in relation to corresponding changes in the parameters indicating disease activity, inflammatory cell infiltration, and immune complex deposition; to isolate mesangial cells from treated and control mice, and to assess in vitro mesangial cell activation and synthesis of inflammatory/fibrosis mediators and matrix components; to investigate whether the actions of MMF or cyclophosphamide on mesangial cells are mediated via the protein kinase C (PKC) pathway. |
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Project Title: |
TGF-beta1 bioactivation in human peritoneal mesothelial cells under elevated glucose concentration - the role of thrombospondin-1 |
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Investigator(s): |
Chan DTM, Yung SSY |
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Department: |
Medicine |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
12/2005 |
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Abstract: |
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Background In Hong Kong, 80% of patients
with end stage renal failure are managed with peritoneal dialysis (PD).
Normal structure and function of the peritoneum are essential to ensure
optimal long-term clinical outcome. Many patients on long-term PD however,
develop progressive thickening of the peritoneal membrane with altered
transport function. The peritoneum is the most extensive serous membrane in
the body, covering the visceral organs and lining the abdominal cavity. It
comprises a monolayer of mesothelial cells resting upon a thin basal lamina,
underneath which is the interstitium that contains a capillary network and
fibroblasts (1). Mesothelial cells are specialized epithelial cells that provide
an anatomical barrier and a frictionless interface for the movement of organs
and tissues (2). They also play a critical role in the control of peritoneal
homeostasis, permselectivity, inflammation and fibrosis. Moreover,
mesothelial cells synthesize and secrete multifunctional molecules including
matrix proteins and glycosaminoglycans including hyaluronan (HA) (3). During
PD a hyperosmolar dialysis solution is allowed to dwell in the peritoneal
cavity for several hours. Metabolic waste, electrolytes, and excessive water
are removed from the circulation by diffusion or convection across the
peritoneal membrane (4, 5). Conventional PD solutions utilize dextrose at
high concentrations, usually 15 to 40 times that of physiological levels, to
provide the osmotic drive for free water removal. This ‘bio-incompatible’
glucose milieu is a major insult to the structural and functional integrity
of the peritoneal membrane (6, 7). The peritoneum in long-term PD exhibits
re-duplication of the basal lamina, increased synthesis and deposition of
matrix within the submesothelium, and progressive subendothelial
hyalinization, with narrowing or obliteration of the vascular lumen (6-8).
These structural changes are accompanied by deranged transport properties. In
vitro studies have shown that high glucose concentrations alter cellular
proliferation and viability, and induce growth factor, cytokine and matrix
protein synthesis in human peritoneal mesothelial cells (HPMC) (9-13).
Repeated chemical or bacterial injury to the peritoneal mesothelium triggers
inflammatory responses and initiates a multitude of reparative processes that
aim to heal but which often result in fibrosis. The mechanisms leading to the
different outcomes are under intense investigation. In vitro studies have
demonstrated that high glucose concentration can modulate cell proliferation
and up-regulate matrix synthesis in HPMC. These changes are mediated through
protein kinase C, and bioactivation of TGF-beta1. TGF-beta1 is normally
synthesized and secreted in its latent form, and must be activated before it
can bind to its receptors and elicit functional changes to the cells.
Therefore, changes in the expression of latent TGF-beta1 will have no
biological effect on HPMC unless mechanisms are present to convert it to its
active form. Studies utilizing platelets and endothelial cells have
demonstrated that physiocochemical activation of TGF-beta1 can occur by
extreme pH or high temperature, limited proteolysis, or binding to various
membrane or extracellular matrix components (14, 15). Activation in vivo is
more complex and remains to be fully elucidated. Recent studies have
demonstrated that the extracellular matrix component thrombospondin-1 (TSP-1)
is a key activator of TGF-beta |
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Project Title: |
Synthesis of cytokines and growth factors during bacterial peritonitis complicating peritoneal dialysis - in vivo and in vitro studies |
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Investigator(s): |
Chan DTM, Yung SSY |
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Department: |
Medicine |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2006 |
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Abstract: |
|
The peritoneum is the most extensive
serous membrane in the body, covering the visceral organs and lining the
abdominal cavity (1). It comprises a monolayer of mesothelial cells
underneath which lies the interstitium that contains fibroblasts, collagen
fibrils, and a capillary network (1). Mesothelial cells are specialized
epithelial cells that provide an anatomical barrier and a frictionless
interface for the movement of organs and tissues. Moreover, they play a
critical role in peritoneal homeostasis, transport functions, inflammation
and tissue remodeling through its controlled synthesis of cytokines,
chemokines, growth factors and matrix proteins (2-6). Peritoneal dialysis
(PD) is recognized as an effective treatment modality for patients with
end-stage renal failure. Currently, 80% of patients with end-stage renal failure
in |
|
Project Title: |
Effect of rapamycin, alone or in combination with mycophenolate mofetil, in the treatment of murine lupus nephritis |
|
Investigator(s): |
Chan DTM, Lui SL, Yung SSY, Chan KW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To investigate and compare the effects of rapamycin and mycophenolate mofetil (MMF), alone or in combination, on phenotypic, serologic, molecular, and histopathologic manifestations of lupus nephritis in NZBWF1/J mice. Spectifically the expression of inflammatory or fibrosis mediators/markers IL-6, IL-2, IL-1β, TNF-α, IFN-γ, hyaluronan, fibronectin, collagen type I and TGF-&beta1 will be examined, especially in mesangial cell and tubular epithelial cells; to examine the effect of rapamycin and MMF on renal histopathology and immune deposits focusing on renal cell proliferation, inflammatory cell infiltration and renal expression of inflammatory/fibrosis markers; to investigate the correlation between therapeutic effects of these drugs and changes in signaling pathways (PKS-α, PKC-βI, PKC--βII, PKC-γ, p38 MAPK, JNK, and ERK pathways, and NF-κB activation) upstream of cytokine/growth factor induction. |
|
List of Research Outputs |
|
Chan
D.T.M., Ng Y.C.C. and Yung S.S.Y., Cytokine induction by
anti-DNA antibodies in proximal renal tubular epithelial cells is reduced by
mycophenolic acid, Journal of the American Society of Nephrology.
2007, 18: |
|
Chan D.T.M., Goals of treatment in lupus nephritis, at the XI Colombian Congress of Rheumatology, Colombian Association of Rheumatology, Medellin, Colombia, August 16-19. 2007. |
|
Chan
D.T.M., Guest Editor, Proceedings for the
11th Congress of the International Society for Peritoneal Dialysis, Peritoneal
Dialysis International. |
|
Chan D.T.M., Histopathological classification of lupus nephritis – implication on treatment, at the XI Colombian Congress of Rheumatology, Colombian Association of Rheumatology,Medellin, Colombia, August 16-19. 2007. |
|
Chan
D.T.M., Lupus Nephritis, 4th HuaXia
Congress on the Diagnosis and Management of Rheumatic Diseases, |
|
Chan D.T.M., Management of lupus nephritis – past, present, and future, at the XI Colombian Congress of Rheumatology, Colombian Association of Rheumatology, Medellin, Colombia, August 16-19. 2007. |
|
Chan D.T.M., Mycophenolate mofetil in the treatment of lupus nephritis - an appraisal of recent data, XI Colombian Congress of Rheumatology, Colombian Association of Rheumatology, 16-19 August, Medellin, Colombia . 2007. |
|
Chan
D.T.M., Mycophenolate mofetil in the
treatment of non-lupus renal diseases, at the 11th Asian Pacific Congress
of Nephrology, |
|
Chan
D.T.M., New treatments for lupus nephritis, at
the 11th Asian Pacific Congress of Nephrology, |
|
Chan D.T.M., Pathogenesis of systemic lupus erythematosus - the role of anti-DNA antibodies, Third Asian Autoimmunity Forum, 27-29 July, Singapore. 2007. |
|
Chan
D.T.M., Lin A.W., Tang S.C.W., Qian J.Q., Lam M.F., Ho
Y.W., Tse K.C., Chan K.W., Lai K.N. and Tang C.S.O., Prospective controlled
study on mycophenolate mofetil and prednisolone in the treatment of
membranous nephropathy with nephrotic syndrome, Nephrology. |
|
Chan
D.T.M., Renal preservatio in chronic
allograft dysfunction after kidney transplanation - immunosuppression vs
non-immunosuppression, Astellas Transplantation Asian-Pacific |
|
Chan
D.T.M., State-of-the-Art lecture: Management
of Lupus Nephritis, Annual Congress of the Chinese Society of Nephrology, |
|
Chan
D.T.M., Treatment of Lupus Nephritis, Roche
Asian Transplantation and Immunology Forum, |
|
Chan
D.T.M., Treatment of lupus nephritis – with
what and for how long, at the American Society of Nephrology Annual
Scientific Meeting, |
|
Chan
D.T.M., Viral hepatitis and kidney
transplantation, at the 10th Congress of the Asian Society of
Transplantation, |
|
Lui
S.L., Tsang R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates
the severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Tse K.C., Yung S.S.Y., Tang S.C.W., Tam S., Lai K.N. and Chan D.T.M., Atorvastatin at conventional dose did not reduce C-reactive protein in patients on peritoneal dialysis, Journal of Nephrology. 2008, 21: 283. |
|
Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
|
Yung S.S.Y. and Chan D.T.M., Anti-DNA antibodies in the pathogenesis of lupus nephritis - the emerging mechanisms [invited review], Autoimmunity Reviews. 2008, 7: 317-321. |
|
Yung
S.S.Y., Tsang R.C.W., Chen X.R.
and Chan D.T.M., Heparin
ameliorates peritoneal dialysate-induced reduction of perlecan synthesis and
cellular transdifferentiation in human peritoneal mesothelial cells, Journal
of the American Society of Nephrology. 2007, 18: |
|
Yung S.S.Y. and Chan D.T.M., Peritoneal proteoglycans: much more than ground substance [invited editorial], Peritoneal Dialysis International. 2007, 27: 375-390. |
|
Researcher
: Chan HHL |
|
Project Title: |
The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota |
|
Investigator(s): |
Chan HHL, Lam LK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2000 |
|
Abstract: |
|
To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota. |
|
Project Title: |
The use of vascular lasers in the treatment of port wine stain in chinese |
|
Investigator(s): |
Chan HHL, Wei WI |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To establish the importance of epidermal cooling when 585nm pulse dye laser is used for the treatment of port wine stain in Chinese; to compare the clinical efficacy, patients' tolerability and complications of two commerical available vascular lasers that are equipped with different cooling devices in the treatment of port wine stain in Chinese. |
|
List of Research Outputs |
|
Yu C.S., Yeung C.K., Shek S.Y.N., Tse R.K., Kono T... and Chan H.H.L., Combined infrared light and bipolar radiofrequency for skin tightening in Asians., Lasers in Surgery and Medicine. 2007, 39(6): 471-5. |
|
Researcher
: Chan JCK |
|
Project Title: |
Application of
the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care
Unit at |
|
Investigator(s): |
Chan JCK, Lam WK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Health Services Research Fund - Full Grants |
|
Start Date: |
07/1995 |
|
Abstract: |
|
To evaluate the usefulness of the APACHE
II and III prognostic scoring methods in the 14-bed ICU at |
|
Researcher
: Chan KH |
|
List of Research Outputs |
|
Chan K.H., Tsang K.L., Fong C.Y., Mak W. and Ho S.L., Clinical Outcome Of Relapsing Remitting Multiple Sclerosis In Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Clinical Outcome of Relapsing Remitting Multiple Sclerosis in Hong Kong Chinese, THe Hong Kong Neurological Scoiety, Multiple Sclerosis Preceptorship Workshop. 2008. |
|
Chan K.H., Pittock S.J. and Lennon V.A., Coexisting autoimmune channelopathies: Neuromyelitis optica (NMO) with myasthenia gravis (MG), Neurology. 2008, 70 (Suppl 1): A236 (Abstract). |
|
Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
|
Chan K.H., Lachance D.H., Harper C.M. and Lennon V.A., Frequency of seronegativity in adult-acquired generalized myasthenia gravis, Muscle & Nerve. 2007, 36: 651-658. |
|
Chan K.H., Inflammatory Myopathies, Metro Daily. 2008. |
|
Chan K.H., Introduction to Multiple Sclerosis (II), Sing Tao Daily. 2008. |
|
Chan K.H., Introduction to Mutliple Sclerosis (I), Sing Tao Daily. 2008. |
|
Chan K.H., Ramsden D.B., Chu A.C.Y., Kwok H.H. and Ho S.L., NMO-IgG in idiopathic inflammatory demyelinating disorders in Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Chan K.H., Cheung R.T.F., Mak W. and Ho S.L., Nonthymoma early-onset and late-onset generalized myasthenia gravis - a retrospective hospital based study, Clinical Neurology and Neurosurgery. 2007, 109: 686-691. |
|
Chan K.H., Pharmacological Treatment of Relapsing Remitting Multiple Sclerosis, Hospital Authority Chief Pharmacist's Office. 2008. |
|
Chan
K.H., Two Forms of Channelopathies, Research
Meeting of the Department of Medicine, LKS Faculty of Medicine, the |
|
Chan K.H., Update on the clinical efficacy of beta-interferon in relapsing remitting multiple sclerosis, Hong Kong Neuromuscular Association. 2008. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Researcher
: Chan KH |
|
List of Research Outputs |
|
Chan K.H., Tsang K.L., Fong C.Y., Mak W. and Ho S.L., Clinical Outcome Of Relapsing Remitting Multiple Sclerosis In Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Clinical Outcome of Relapsing Remitting Multiple Sclerosis in Hong Kong Chinese, THe Hong Kong Neurological Scoiety, Multiple Sclerosis Preceptorship Workshop. 2008. |
|
Chan K.H., Pittock S.J. and Lennon V.A., Coexisting autoimmune channelopathies: Neuromyelitis optica (NMO) with myasthenia gravis (MG), Neurology. 2008, 70 (Suppl 1): A236 (Abstract). |
|
Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
|
Chan K.H., Lachance D.H., Harper C.M. and Lennon V.A., Frequency of seronegativity in adult-acquired generalized myasthenia gravis, Muscle & Nerve. 2007, 36: 651-658. |
|
Chan K.H., Inflammatory Myopathies, Metro Daily. 2008. |
|
Chan K.H., Introduction to Multiple Sclerosis (II), Sing Tao Daily. 2008. |
|
Chan K.H., Introduction to Mutliple Sclerosis (I), Sing Tao Daily. 2008. |
|
Chan K.H., Ramsden D.B., Chu A.C.Y., Kwok H.H. and Ho S.L., NMO-IgG in idiopathic inflammatory demyelinating disorders in Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Chan K.H., Cheung R.T.F., Mak W. and Ho S.L., Nonthymoma early-onset and late-onset generalized myasthenia gravis - a retrospective hospital based study, Clinical Neurology and Neurosurgery. 2007, 109: 686-691. |
|
Chan K.H., Pharmacological Treatment of Relapsing Remitting Multiple Sclerosis, Hospital Authority Chief Pharmacist's Office. 2008. |
|
Chan
K.H., Two Forms of Channelopathies, Research
Meeting of the Department of Medicine, LKS Faculty of Medicine, the |
|
Chan K.H., Update on the clinical efficacy of beta-interferon in relapsing remitting multiple sclerosis, Hong Kong Neuromuscular Association. 2008. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Researcher
: Chan MMW |
|
Project Title: |
A surveillance program of tuberculosis in old age homes in Hong Kong |
|
Investigator(s): |
Chan MMW, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Government Tuberculosis and Chest Service (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects to evaluate the effectiveness of the program. |
|
Project Title: |
A surveillance program of tuberculosis in old age homes in Hong Kong |
|
Investigator(s): |
Chan MMW, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
01/2004 |
|
Abstract: |
|
To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Tuberculosis and Chest Service, Department of Health (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects; to evaluate the effectiveness of the program. |
|
List of Research Outputs |
|
Becker A. and Chan M.M.W., Primary asthma prevention: is it possible? (Review), Curr Allergy Asthma Rep. 2008, 8(3): 255-61. |
|
Beyers N., Pierard C., Enarson D.A. and Chan M.M.W., What new knowledge did we gain through The International Journal of Tuberculosis and Lung Disease in 2007? (Review) , Int J Tuberc Lung Dis. . 2008, 12(4): 347-57. |
|
Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A., Zuberbier T., Baena-Cagnani C.E., Canonica G.W., van Weel C., Agache I., Ait-Khaled N., Bachert C., Blaiss M.S., Bonini S., Boulet L.P., Bousquet P.J., Camargos P., Carlsen K.H., Chen Y., Custovic A., Dahl R., Demoly P., Douagui H., Durham S.R., van Wijk R.G., Kalayci O., Kaliner M.A., Kim Y.Y., Kowalski M.L., Kuna P., Le L.T., Lemiere C., Li J., Lockey R.F., Mavale-Manuel S., Meltzer E.O., Mohammad Y., Naclerio R., O'Hehir R.E., Ohta K., Ouedraogo S., Palkonen S., Papadopoulos N., Passalacqua G., Pawankar R., Popov T.A., Rabe K.F., Rosado-Pinto J., Scadding G.K., Sinons F.E., Toskala E., Valovirta E., van Cauwenberge P., Wang D.Y., Wickman M., Yawan B.P., Yorgancioglu A., Yusuf O.M., Zar H., Annesi-Maesano I., Bateman E.D., Ben Kheder A., Boakye D.A., Bouchard J., Burney P., Busse W.W. and Chan M.M.W., Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Review, Allergy. 2008, 63 Suppl 86: 8-160. |
|
Chan
M.M.W. and Ip
M.S.M., Asthma, In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Chan M.M.W., Dimich-Ward H. and Becker A., Atopy in early life and effect of a primary prevention program for asthma in a high-risk cohort. , J Allergy Clin Immunol. 2007, 120(5): 1221-3. |
|
Chan
M.M.W., Dai D.L., Cheung A.H.K., Chan F.H., Kam K.M., Tam
C.M. and Leung C.C., Tuberculin skin test reaction and body mass index in old
age home residents in |
|
Dimich-Ward H., Taliadouros V., Teschke K., Chow Y., Abboud R. and Chan M.M.W., Quality of life and employment status of workers with Western red cedar asthma. , Occup Environ Med J. 2007, 49(9): 1040-5. |
|
Ho P.L., Becker M. and Chan M.M.W., Emerging occupational lung infections. , Int J Tuberc Lung Dis. 2007, Jul;11(7): 710-21. |
|
Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L., Tang
K.S., Yam L.Y.C. and Chan M.M.W., Variability of the
prevalence of undiagnosed airflow obstruction in smokers using different
diagnostic criteria, 12th Congress of the Asian Pacific Society of
Respirology / 2nd Joint Congress of the Asian Pacific Society of
Respirology/American College of Chest Physicians, Queensland, Australia.
Respirology. 2007, 12 (supp 4): A115 ( |
|
Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L., Tang K.S., Yam L.Y.C. and Chan M.M.W., Variability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteria, Chest. 2008, 133: 42-48. |
|
Mak
J.C.W., Leung H.C.M., Sham A.S., Mok T.Y., Poon Y.N., Ling S.O., Wong
K.C. and Chan M.M.W., Genetic
polymorphisms and plasma levels of transforming growth factor-beta |
|
Mak J.C.W., Ho S.P., Ho A.S.S., Law B.K., Ho J.C.M. and Chan M.M.W., Increased oxidative stress during acute asthma exacerbation in Hong Kong Chinese asthmatics, Pro Am Thorac Soc. 2008, 3: A472. |
|
Mak
J.C.W., Ho S.P., Yu W.C., Choo
K.L., |
|
Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
|
Marks G. and Chan M.M.W., COPD: a new global challenge to lung health. , Int J Tuberc Lung Dis. 2008, 12(1): 2. |
|
Wong M.K.Y., Ho J.C.M. and Chan M.M.W., Interstitial and
occupational lung diseases, In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical
Respiratory Medicine. |
|
Researcher
: Chan MW |
|
List of Research Outputs |
|
Malo J.L. and Chan M.W., Asthma in the workplace: a Canadian contribution and perspective. (Review) , Can Respir J. 2007, 14(7): 407-13. |
|
Researcher
: Chan TK |
|
List of Research Outputs |
|
Chan V.N.Y., Chan J., Chim J.C.S., Ooi C.G.C. and Chan T.K., Iron overload in Hb H disease, Fourth International Eijkman Conference, Bali, Indonesia, November 15-18. 2007. |
|
Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
|
Researcher
: Chan VNY |
|
Project Title: |
Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis |
|
Investigator(s): |
Chan VNY, Chan K, Luk KDK, Cheng CK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To identify genes along the mouse chromosome 17 (which is in synteny to human chromosome 19p), that are expressed in tissues associated with AIS phenotype, such as muscle, bone, cartilage, tendon, etc; to identify by differential gene expression analysis those genes along human chromosome 19p13, expressed (differently- decreased or increased) in AIS patients compared to human control subjects; to sequence those genes of interest in genomic DNA of the indexed patients in the relevant AIS families, in order to identify the causative mutations. |
|
Project Title: |
Epigenetic and genetic regulation of the AMIGO3 gene in carcinoma of the breast |
|
Investigator(s): |
Chan VNY, Chow LWC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
We have identified in breast tumours
several aberrantly methylated DNA fragments, one of which corresponds to the
5' flanking region of the amphoterin-induced gene and ORF3 (AMIGO3). It is a
member of a novel family of transmembrane proteins containing six leucine
rich repeats and one immunoglobulin-like domain [1]. We observed that AMIGO3
5' flanking region is frequently methylated in primary breast cancers (40.4%)
and in 4 breast cancer cell lines. Furthermore, AMIGO3 5' flanking region
methylation is associated with over-expression of mRNA and correlated
positively with lymph node metastasis (p=0.037). The mechanism for this
unexpected epigenetic or genetic effects required further elucidation.
Recently another member of this family, AMIGO2 has been found to be
associated with human gastric adenocarcinoma, with effects on ploidy,
chromosomal stability, cell adhesion/migration and tumorigenicity [2]. A
homophilic and heterophilic binding mechanism exists between the members of
the AMIGO family. AMIGO expression can be induced by ligation of the Ig
superfamily protein RAGE by amphoterin[1]. Since RAGE is known to play a role
in tissue injury and in regulation of cell motility [3,4], it is possible
that AMIGO3 plays a significant role in cancer cell metastasis. We hope to
study the epigenetic and genetic regulation of AMIGO3 and explore its
usefulness as a possible molecular marker in breast cancer. References:- [1]
Kuja-Panula J, Kiiltomaki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a
transmembrane protein implicated in axon tract development, defines a novel
protein family with leucine-rich repeats. J Cell Biol 2003; 160:963-973. [2]
Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS.
DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed
in human gastric adenocarcinoma: effects on ploidy, chromosomal stability,
cell adhesion/migration and tumorigenicity. Oncogene 2004; 23:5056-5067. [3]
Rauvala H, Huttunen HJ, Fages C, Kaksonen M, Kinnunen T, Imai S, Raulo E,
Kilpelainen I. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin
in the regulation of cell motility. Matrix Biol 2000; 19:377-387. [4] Schmidt
AM, |
|
Project Title: |
Hepatitis B virus array for genotyping and mutation detection |
|
Investigator(s): |
Chan VNY, Lai CL, Chan K, Yuen RMF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
11/2006 |
|
Abstract: |
|
To design a comprehensive hepatitis B virus array for the simultaneous analysis of 8 HBV genotypes, 5 precore, 4 core promoter, 23 S gene and 44 polymerase gene mutations. A total of 88 variants will be assessed; to assess the sensitivity of the system; to monitor 50 patients on anti-viral therapy over a period of 18 months to detect any development of drug resistance by detection of viral mutants in their serum sample |
|
Project Title: |
A simplified, non-fluorescent based microarray system for Thalassaemia screening and mutation detection |
|
Investigator(s): |
Chan VNY, Chan K |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2006 |
|
Abstract: |
|
The proposal is to devise another means
of signal detection, without using fluorescein label in the AS-APEX reaction
on the thalassaemia array, obviating the need for a laser scanner. Hence,
this will allow the thalassaemia array screening and mutation detection
procedure to be implemented in many more laboratories.This will be a very affordable
and rapid method for thal screening and mutation detection that is much
needed in many countries in |
|
List of Research Outputs |
|
Chan
V.N.Y., Co-chairman, 11th Congress
of the International Society of Hematology, Asian-Pacific Division
(ISH-APD2007), Session 3 on “Hemorrage/Thrombosis, Erythroid Disorders”, |
|
Chan V.N.Y., Core Member, Global Burden of Disease Project Group (jointly organized by the World Health Organization, Harvard School of Public Health and the World Bank) [since 2007] . 2008. |
|
Chan
V.N.Y., Iron overload in Hb H disease, Fourth
International Eijkman Conference, |
|
Chan V.N.Y., Chan J., Chim J.C.S., Ooi C.G.C. and Chan T.K., Iron overload in Hb H disease, Fourth International Eijkman Conference, Bali, Indonesia, November 15-18. 2007. |
|
Chan
V.N.Y., Member, Central Committee on Clinical
Genetics, Hospital Authority, |
|
Chan
V.N.Y., Member, International Advisory
Committee, 11th Congress of the International Society of Hematology,
Asian-Pacific Division (ISH-APD2007), |
|
Chan V.N.Y., Member, International Scientific Committee, 17th International Conference on Chelation (ICOC) for the Treatment of Thalassaemia, Cancer and other Diseases related to Metal and Free Radical Imbalance and Toxicity, Shenzhen, China, November. 2007. |
|
Chan
V.N.Y., Preimplantation Genetic Diagnosis of
Thalassaemias, Invited Speaker at the 11th Congress of the International
Society of Hematology, Asian-Pacific Division (ISH-APD2007), |
|
Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
|
Chan
V.N.Y., Preimplantation genetic diagnosis of
thalassaemias, 11th Congress of the International
Society of Hematology, Asian-Pacific Division (ISH-APD2007), |
|
Chan
V.N.Y., Preimplantation genetic diagnosis, Postgraduate
Study Day, Department of Obstetrics & Gynaecology, The |
|
Chan V.N.Y., Prevention and control of thalassemia, Invited by the Ministry of Health, Thailand to speak at the Second Asian Thalassemia Network Meeting, Bangkok, Thailand on October 18. 2007. |
|
Chan V.N.Y., Prevention and control of thalassemias in Hong Kong, Second Asian Network for Thalassemia Control Meeting, Bangkok, Thailand, October 18. 2007. |
|
Chan
V.N.Y., Recent advances in molecular
diagnosis of thalassemia, 7th Human Genome
Organization – Asia Pacific |
|
Chan
V.N.Y., Taught at Master of Public Health
Modules, CME06216 Public Health Genetics Course organized by Department of
Community Medicine, Faculty of Medicine, |
|
Cheung C.L., Chan V.N.Y. and Kung A.W.C., A differential association of ALOX15 polymorphisms with bone mineral density in pre- and postmenopausal women., Human Heredity. 2008, 65(1): 1-8. |
|
Cheung C.L., Huang Q., Chan V.N.Y. and Kung A.W.C., Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women., Hum Hered. 2007, 65(4): 232-239. |
|
Cheung C.L., Sham P.C., Chan V.N.Y., Paterson A.D., Luk K.D.K. and Kung A.W.C., Identification of LTBP2 on chromosome 14q as a novel candidate gene for BMD variation and fracture risk association, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
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Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282. |
|
Leung K.Y., Cheong K.B., Tang M.H.Y. and Chan V.N.Y., Prenatal diagnosis of thalassemia, Journal of Paediatrics, Obstetrics & Gynaecology. 2008, 34: 37-42. |
|
Researcher
: Chan WL |
|
List of Research Outputs |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Leung J.C.K., Tang S.C.W., Chan Y.Y., Chan W.L. and Lai K.N., Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA-role of MAPK and NFkB, Nephrology Dialysis Transplantation. 2008, 23: 72-81. |
|
Researcher
: Chan WM |
|
List of Research Outputs |
|
Chan
W.M. and Lam
W.K., Respiratory failure and acute respiratory distress syndrome, In
Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory Medicine, 3rd
Edition, 2007. |
|
Wang J.K.L. and Chan W.M., Practical principles on
ventilatory support, In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Researcher
: Chan YH |
|
List of Research Outputs |
|
Lau
G.K.K., Chan Y.H.,
Yiu K.H., Tam S., Li S.W., Lau C.P.
and Tse H.F., Incremental predictive
value of vascular assessments with |
|
Researcher
: Chan YY |
|
List of Research Outputs |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Lai K.N., Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Lai F.M. and Tang S.C.W., Activation of podocytes by mesangial-derived TNF-{alpha}: glomerulo-podocytic communication in IgA nephropathy, American Journal of Physiology Renal Physiology. 2008, 294: F945-F955. |
|
Leung
J.C.K., Tang S.C.W., Lam M.F., Chan Y.Y. and Lai K.N., Serum and spent peritonitis
fluid concentration of neutrophil gelatinase-associated lipocalin (NGAL) in
peritonitis, Peritoneal Dialysis International. |
|
Leung J.C.K., Tang S.C.W., Chan Y.Y., Chan W.L. and Lai K.N., Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA-role of MAPK and NFkB, Nephrology Dialysis Transplantation. 2008, 23: 72-81. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Eddy A.A. and Lai K.N., Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy, Kidney International. 2008, 73: 288-299. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Researcher
: Chang PCM |
|
List of Research Outputs |
|
Mak C.M., Kwong Y.L., Lam C.W., Chan S.C., Lo C.M., Fan S.T., Chang P.C.M., Lau Y.K., Lok Sun U. and Tam S., Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese, Amyloid. 2007, 14(4): 293-297. |
|
Ng
F.H., Wong S.Y., Lam K.F., Chang P.C.M., Lau Y.K., |
|
Ng
F.H., Lam K.F., Wong S.Y., Chang P.C.M., Lau Y.K., Yuen W.C., |
|
Researcher
: Chao DVK |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Hong T.C., Lam T.P. and Chao D.V.K., 2008 Hong Kong College
of Family Physicians Best Research Award for a study on " Barriers for
primary care physicians in providing palliative care service in Hong
Kong".. , |
|
Hong T.C., Lam T.P. and Chao D.V.K., 41. Barriers for
Primary Care Physicians in providing Palliative Care Service in Hong Kong,, 14th
|
|
Researcher
: Chau MC |
|
List of Research Outputs |
|
Chau M.C., Chow W.H., Wang E. and Kwong Y.L., Cardiac amyloidosis - experience in a tertiary cardiac referral centre, International journal of cardiology. 2008, 124(2): 264-6. |
|
Researcher
: Chen H |
|
List of Research Outputs |
|
Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells in patients with type II diabetes. , Mol Nutr Food Res (in press). 2008. |
|
Zhang X., Chen H., Siu D.C.W., Yiu K.H., Chan W.S., Lee K.L., Chan H.W., Lee S.W., Fu G.S., Lau C.P. and Tse H.F., New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function., Journal of Cardiovascular Electrophysiology. 2008, 19(2): 136-141. |
|
Researcher
: Chen J |
|
List of Research Outputs |
|
Chen J., Lau C.P. and Li G.R., Characterization of Ca2+ signaling pathways in human cardiac fibroblast, 12th Research postgraduate symposium, HKU.. 2007, 46. |
|
Chen J., Lau C.P. and Li G.R., Characterization of calcium signaling pathways in human cardiac fibroblast., FEBS J/33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 350. |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Researcher
: Chen JY |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Ip M.S.M., Patil N.G., Chen J.Y. and Chan L.K., Advantages of video trigger in problem-based learning, In: , The 4th Congress of the Asian Medical Education Association. 2007. |
|
Researcher
: Chen WH |
|
Project Title: |
Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition |
|
Investigator(s): |
Chen WH, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
06/2001 |
|
Abstract: |
|
To compare the safety, efficacy, anticoagulation profile and level of platelet inhibition in patients undergoing percutaneous coronary intervention using enoxaparin/eptifibatide, unfractionated heparin/epitfibatide, enoxaparin/abciximab, and unfractionated heparin/abciximab. |
|
Project Title: |
A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention |
|
Investigator(s): |
Chen WH, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To identity the clinical and lesion characteristics that determine the quantity of embolized debris captured by a distal protection device during native vessel PCI. |
|
Project Title: |
A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention |
|
Investigator(s): |
Chen WH, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To compare the incidence and magnitude of myoecrosis between aspirin-sensitive and -resistant patients undergoing PCI. |
|
List of Research Outputs |
|
Chen W.H., Cheng X., Lee P.Y., Ng W., Kwok J.Y., Tse H.F. and Lau C.P., Aspirin resistance and adverse clinical events in patients with coronary artery disease., Am J Med. 2007, 120(7): 631-5. |
|
Researcher
: Chen Y |
|
List of Research Outputs |
|
Chen Y., Zhang H., Lu L. and Lau G., Role of Regulatory T cells in Natural Immunity and Sustained Pharmacological Control of Chronic HBV, 2007 Liver Meeting/American Association for the Study of Liver Diseases. 2008. |
|
Researcher
: Cheng C |
|
Project Title: |
Cultural differences in adaptation to the changing environment: A cultural-moderational model of coping flexibility |
|
Investigator(s): |
Cheng C |
|
Department: |
Psychology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To expand the scope of the current conceptualization of coping flexibility from an intra-personal to an interpersonal perspective; to formulate a new conceptual model to explicate cultural differences in coping flexibility and why such cultural differences exist; to develop and validate the various constructs of the proposed model; to adopt a multimethod approach for testing the assumptions and hypotheses of the new model with sophisticated methods. |
|
Project Title: |
The Role of Dialectical Thinking in Flexible Coping |
|
Investigator(s): |
Cheng C |
|
Department: |
Psychology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
10/2006 |
|
Abstract: |
|
Purpose of Proposed Project The proposed
project will seek to explore the cognitive underpinning underlying flexible
coping processes. Dialectical thinking style is proposed to be a cognitive
mechanism underlying coping flexibility. Dialectical thinking is a cognitive
style characterized by a set of principles related to dialectic perspectives
on change, contradiction, and meaning of events (see e.g., Basseches, 1984;
Peng, Spencer-Rodgers, & Nian, 2006). Two studies will be conducted to
address this unexplored issue. The major aim of Study 1 will examine the
hypothesized link between dialectical thinking and coping flexibility in a
cross-sectional design. Study 2 will seek to clarify the direction of this
link in an experimental setting. Key Issues and Problems Being Addressed Most
previous studies examined the personality characteristics and psychological
consequences related to coping flexibility, but not much effort has been made
in exploring the cognitive underpinnings of coping flexibility. The
mechanisms underlying flexible coping processes thus remained unknown.
Exploring the thinking style that influences coping flexibility may help to
distinguish flexible copers from inflexible ones, thus enhancing the
explanatory and predictive power of findings. In addition, most existing
studies have adopted only questionnaires in a cross-sectional design, thus
leaving the direction of relationships among the variables unknown. The
experimental approach can fill this gap by manipulating the cognitive
variables and examining possible changes in behaviors in response to these
manipulations. The cognitive variables that constitute such behavioral changes
can be clarified in a laboratory setting. References Basseches, M. (1984).
Dialectical thinking and adult development. |
|
Researcher
: Cheng CH |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Researcher
: Cheng CTK |
|
List of Research Outputs |
|
Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
|
Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
|
List of Research Outputs |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis , 13 th Medical Research Conference, The University of Hong Kong. 2008. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis, 13th Medical Research Conference, HKU, 19 Jan 2008, Hong Kong. 2008. |
|
Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
|
Zhu
W., Cheng K.Y., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Vascular effects of adiponectin:
molecular mechanisms and potential therapeutic intervention, Clin Sci ( |
|
List of Research Outputs |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis , 13 th Medical Research Conference, The University of Hong Kong. 2008. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis, 13th Medical Research Conference, HKU, 19 Jan 2008, Hong Kong. 2008. |
|
Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
|
Zhu
W., Cheng K.Y., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Vascular effects of adiponectin:
molecular mechanisms and potential therapeutic intervention, Clin Sci ( |
|
Researcher
: Cheng YY |
|
List of Research Outputs |
|
Cheng Y.Y., Yu J., Wong Y.P., Man E.P., To K.F., Jin V.X., Li J., Tao Q., Sung J.J., Chan F.K. and Leung W.K., Frequent Epigenetic Inactivation Of Secreted Frizzled-related Protein 2 (SFRP2) By Promoter Methylation In Human Gastric Cancer, In: Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK, British Journal Of Cancer . 2007, 97(7): 895-901. |
|
Researcher
: Cheung AHK |
|
List of Research Outputs |
|
Chan
M.M.W., Dai D.L., Cheung A.H.K.,
Chan F.H., Kam K.M., Tam C.M. and Leung C.C., Tuberculin skin test reaction
and body mass index in old age home residents in |
|
Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
|
Researcher
: Cheung BMY |
|
Project Title: |
Detection of human body temperature with infrared thermographic imaging: accuracy and feasibility in detection of fever in human subjects |
|
Investigator(s): |
Cheung BMY, Chan LS, Kumana CR |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
09/2005 |
|
Abstract: |
|
The study will provide crucially needed information for the refinement and optimization of the application of the infrared thermography (IRT) technique as a fever screening mechanism. |
|
Project Title: |
Identifying a new gene for hypertension on chromosome 17 |
|
Investigator(s): |
Cheung BMY, Wong LYF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
ObjectivesTo identify a new gene for
hypertension in the 17p12 region on chromosome 17BackgroundPrimary or
essential hypertension results from the interaction between genetic
predisposition and environmental factors. The leading environmental factor is
obesity [1]. We have found this both in cross-sectional studies and in the
Hong Kong Cardiovascular Risk Factor Prevalence Study cohort [2]. In the last
decade, many promising candidate genes for hypertension have been examined.
We believe that a gene that causes hypertension is likely to be associated
with obesity and other components of the metabolic syndrome.A genome scan of
blood pressure-regulating genes done in Chinese sib pairs undertaken in Anhui
in collaboration with Harvard University showed that the microsatellite
marker D17S1303, which consists of GATA repeats, had a high LOD score [3].
This marker lies close to a quantitative trait locus for abdominal
obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17 [4]. We
confirmed that D17S1303 was associated with hypertension in Hong Kong Chinese
[5]. The number of GATA repeats correlated inversely with diastolic blood
pressure and BMI. Nine GATA repeats were associated with hypertension whilst
14 GATA repeats were associated with normotension. Next, we studied SNPs
around D17S1303 and their association with hypertension (CRCG small project
grant 2004 (completed); Title: A gene locus for hypertension and obesity on
chromosome 17) [6]. Candidate SNPs within 3kb of D17S1303 were selected from
an SNP database (Fig. 1). High-throughput genotyping of the SNPs was
performed using the Sequenom MassARRAY system (Sequenom, |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Diabetes: The Asian Epidemic of CV Risk, Leaders Program in CV Risk Management 2007. |
|
Cheung
B.M.Y., Hypertension in |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
|
Chu L.W., Li Y., Tang A.Y.B., Cheung B.M.Y., Leung Y.H., Yik P.Y., Jin D. and Song Y., A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer' s disease in Chinese, Am J Med Genet B. 2007, 144(8): 1007-13. |
|
Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
|
Epstein R. and Cheung B.M.Y., Loading doses for costly cancer biologicals: sound pharmacology or unnecessary extravagance? , Eur J Cancer. 2008, 44(11): 1488-92. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
|
Ong K.L., Tso A.W.K., Lam K.S.L. and Cheung B.M.Y., Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension, Hypertension. 2008, 51: 1142-8. |
|
Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
|
Song L., Koo M.W.L., Cheung B.M.Y. and Lau C.P., Effects of green tea on hypercholesterolemia induced hypertension in rats, Southeast Asian Western Pacific Regional Federation of Pharmacologists and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Meeting. 2007. |
|
Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72. |
|
Woo J., Cheung B.M.Y., Ho S., Sham A. and Lam T.H., Influence of dietary pattern on the development of overweight in a Chinese population, European Journal of Clinical Nutrition. 2008, online: 1-8. |
|
Researcher
: Cheung CL |
|
List of Research Outputs |
|
Cheung C.L., Chan V.N.Y. and Kung A.W.C., A differential association of ALOX15 polymorphisms with bone mineral density in pre- and postmenopausal women., Human Heredity. 2008, 65(1): 1-8. |
|
Cheung C.L., Huang Q., Chan V.N.Y. and Kung A.W.C., Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women., Hum Hered. 2007, 65(4): 232-239. |
|
Cheung C.L., Tang L.F., Sham P.C., McClug P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide Haplotype Association Mapping (HAM) in Mice Leads to an Identification of a Genetic Variant in CER1 Associated with Bone Mineral Density in Premenopausal Women, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. |
|
Cheung C.L., Tang P.L.F., Sham P.C., McClurg P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping (HAM) in mice leads to an identification of a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Cheung C.L., Sham P.C., Chan V.N.Y., Paterson A.D., Luk K.D.K. and Kung A.W.C., Identification of LTBP2 on chromosome 14q as a novel candidate gene for BMD variation and fracture risk association, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
|
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282. |
|
Ip P.P.C., Lam K.W., Cheung C.L., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid-associated Necrosis and Intralesional Thrombosis of Uterine Leiomyomas: A Clinicopathologic Study of 147 Cases Emphasizing the Importance of Drug-induced Necrosis and Early Infarcts in Leiomyomas , American Journal of Surgical Pathology. 2007, 31(8): 1215-1224. |
|
Lai M.H., Cheung C.L., Luk K.D.K. and Kung A.W.C., Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women, Osteoporosis International. 2007, 19: 571-9. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese population., 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Annul Scientific Meeting, Hong Kong. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Multifactor Dimensionality Reduction Reveals Antagonistic Epistasis Between ESR1 and ESR2 with BMD Variation in Southern Chinese Women, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Researcher
: Cheung CL |
|
List of Research Outputs |
|
Cheung C.L., Chan V.N.Y. and Kung A.W.C., A differential association of ALOX15 polymorphisms with bone mineral density in pre- and postmenopausal women., Human Heredity. 2008, 65(1): 1-8. |
|
Cheung C.L., Huang Q., Chan V.N.Y. and Kung A.W.C., Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women., Hum Hered. 2007, 65(4): 232-239. |
|
Cheung C.L., Tang L.F., Sham P.C., McClug P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide Haplotype Association Mapping (HAM) in Mice Leads to an Identification of a Genetic Variant in CER1 Associated with Bone Mineral Density in Premenopausal Women, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. |
|
Cheung C.L., Tang P.L.F., Sham P.C., McClurg P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping (HAM) in mice leads to an identification of a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Cheung C.L., Sham P.C., Chan V.N.Y., Paterson A.D., Luk K.D.K. and Kung A.W.C., Identification of LTBP2 on chromosome 14q as a novel candidate gene for BMD variation and fracture risk association, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
|
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282. |
|
Ip P.P.C., Lam K.W., Cheung C.L., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid-associated Necrosis and Intralesional Thrombosis of Uterine Leiomyomas: A Clinicopathologic Study of 147 Cases Emphasizing the Importance of Drug-induced Necrosis and Early Infarcts in Leiomyomas , American Journal of Surgical Pathology. 2007, 31(8): 1215-1224. |
|
Lai M.H., Cheung C.L., Luk K.D.K. and Kung A.W.C., Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women, Osteoporosis International. 2007, 19: 571-9. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese population., 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Annul Scientific Meeting, Hong Kong. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Multifactor Dimensionality Reduction Reveals Antagonistic Epistasis Between ESR1 and ESR2 with BMD Variation in Southern Chinese Women, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Researcher
: Cheung KF |
|
List of Research Outputs |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Researcher
: Cheung MS |
|
List of Research Outputs |
|
Li
S.K.M., Smith D.K., Leung G.W.Y., Cheung M.S., Lam E.W., Dimri G.P.
and Yao K.M., FoxM |
|
Researcher
: Cheung RTF |
|
Project Title: |
Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits |
|
Investigator(s): |
Cheung RTF, Li LSW, Yang ES, Leung KP, Li G |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To use functional magnetic resonance imaging (MRI) to identify stroke patients with or without activations of brain sites relevant to their persistent arm paralysis or language impairment during stimulation of the deficit-implicated acupoints and then apply randomized, double-blinded, acupoint-controlled clinical trials to confirm the benefits of acupuncture in post-stroke rehabilitation of the deficit. The results will confirm the value of functional MRI in identifying responders to acupuncture in post-stroke motor or language rehabilitation and reveal the benefit of acupuncture treatment over certain disease-implicated acupoints. |
|
Project Title: |
Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice |
|
Investigator(s): |
Cheung RTF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To study (1) the influence of genotype on the cerebral blood flow and infarct volume of transgenic mice overexpressing amyloid precursor protein (APP) alone or with human mutant presenilin-1 (PS-1) gene following photothrombotic stroke, and to study (2) the effects of photothrombotic stroke on the sensorimotor functions and visuospatial memory in the APP transgenic mice and APP/PS-1 double transgenic mice. |
|
Project Title: |
Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients |
|
Investigator(s): |
Cheung RTF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
04/2005 |
|
Abstract: |
|
To develop Chinese-language versions of internationally-accepted stroke training materials, and to make them available to healthcare professionals treating Chinese stroke patients. |
|
Project Title: |
Effects of neuropeptide Y-Y1 and Y2 receptor activation or inhibition on free radical generation and intracellular calcium concentration |
|
Investigator(s): |
Cheung RTF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Purpose (1) To study the effects of neuropeptide Y (NPY) and its Y1 or Y2 agonists and antagonists on generation of nitric oxide (NO) and superoxide anion as well as intracellular calcium ion concentration in in vivo and in vitro stroke models (2) To study the interactions of NPY and its Y1 or Y2 agonists and antagonists with inhibitors of NO synthase or NO donor in in vivo and in vitro stroke models Key Issues There is evidence that NPY mediates ischemic damage via its Y1 receptors during focal cerebral ischemia and that inhibition of the Y1 receptors may confer neuroprotection against ischemic injury. The underlying mechanisms are unknown, and preliminary information suggests that the opposite actions of NPY on neuronal and endothelial NO synthase may be relevant. According to the literature, generation of free radicals, such as NO and superoxide anion, mediates ischemic injury. Elevation of intracellular calicum concentration also lead to ischemic damage via activation of intracellular enzymes, including neuronal NOS. On the other hand, activation of endothelial NOS maintains microcirculation and lessens the ischemic injury. Problems being addressed (1) Ability of NPY Y1 or Y2 agonist/antagonist to attenuate/augment ischemia-stimulated increase in brain levels of NO and superoxide anion (2) Ability of NPY Y1 or Y2 agonist/antagonist to attenuate/augment ischemia-stimulated rise in intracellular calcium ion concentration (3) Interactions between NPY Y1 or Y2 agonist/antagonist and NO donor or NO synthase inhibitor in stroke models |
|
Project Title: |
Study of bone marrow-derived stem cell transplantation in rodent stroke models |
|
Investigator(s): |
Cheung RTF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2006 |
|
Abstract: |
|
Objectives: (1) To evaluate the functional and histological benefits of peripheral blood progenitor cells (PBPC; bone marrow-derived stem cells) mobilized by granulocyte-colony stimulating factor (G-CSF) in an in vivo mice stroke model. (2) To compare among different route of administration of G-CSF-mobilized PBPC in an in vivo mice stroke model. Key issues: (1) Stem cell transplantation can theoretically restore some of the lost brain functions and reconstruct the damaged neuronal circuitry after stroke. (2) The desirable site of transplantation and source of stem cells await clarification. (3) There is preliminary evidence of neuroprotective potentials of G-CSF. (4) G-CSF can mobilize PBPC, a form of pluripotent stem cells derived from the bone marrow. Problems addressed: (1) Potential benefits of autologous bone marrow-derived stem cells in post-stroke functional and histological recovery. (2) Comparing different route of administration of bone marrow-derived stem cells. |
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List of Research Outputs |
|
Chan C.F., Leung A.Y.H., Chan Y.S. and Cheung R.T.F., Central administration of granulocyte- colony stimulating factor in a mice middle cerebral artery occlusion stroke model reduces infarct volume and improves functional outcome, Soc. Neuroscience Abstract (U.S.A.): 598.1. 2007. |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Chan K.H., Cheung R.T.F., Mak W. and Ho S.L., Nonthymoma early-onset and late-onset generalized myasthenia gravis - a retrospective hospital based study, Clinical Neurology and Neurosurgery. 2007, 109: 686-691. |
|
Cheung R.T.F., A patient with hemiplegia and aphasia; Advances in stroke treatment and prevention, Case & Mini-lecture IX, Beijing-Hong Kong Medical Forum 2008, Beijing, China. 2008. |
|
Cheung
R.T.F., Academic Committee Member, Scientific
Session Chairman, Beijing-Hong Kong Medical Forum 2008, Presidential
Hotel, |
|
Cheung
R.T.F., Acupuncture in Stroke Rehabilitation,
Theme on New Research Methodology in Chinese Medicine, Symposium on Global
Development in Chinese Medicine, |
|
Cheung
R.T.F., Acute Management of Ischemic Stroke, Symposium
on Stroke, |
|
Cheung R.T.F., Acute Stroke Management: An Appraisal of Current and Developing Therapeutic Options, Neurology / Medical Ophthalmology Session, 13th Hong Kong Medical Forum, Hong Kong Convention & Exhibition Centre, Wanchai, Hong Kong. 2008. |
|
Cheung
R.T.F., Acute Stroke Management, Symposium
on Cardiovascular Risks, The Association of Private Medical Specialists of |
|
Cheung
R.T.F., Acute stroke management: an appraisal
of current and developing therapeutic options, 13th |
|
Cheung
R.T.F., Advances in stroke treatment and
prevention, Beijing-Hong Kong Medical Forum 2008. |
|
Cheung
R.T.F., An overview of stroke, 中風淺析, 戰勝中風症, |
|
Cheung
R.T.F., An overview on Parkinsonism in
Chinese, Metro Daily. |
|
Cheung
R.T.F., An overview on Parkinsonism in
English, Metro Daily. |
|
Cheung
R.T.F., Cardiac and Cerebral Mechanisms of
Sudden Death, Conference for Clinical Advance in Neurology, |
|
Cheung
R.T.F., Chairman of Organizing Committee, The
First International Symposium on Visually Induced Motion Sickness, Fatigue,
and Photosensitive Epileptic Seizures, VIMS 2007, HKUST, |
|
Cheung R.T.F., Chairman, Multidisciplinary CME-accredited Meeting, The Primary Care Clinic, Kowloon Shangri-La Hotel, Tsimshatsui. 2007. |
|
Cheung R.T.F., Chairman, Second Quarterly Scientific Meeting of Hong Kong Stroke Society, Seminar Room 1, M/F, HAHO. 2008. |
|
Cheung
R.T.F., Congratulatory message to Hong Kong
Stroke Association, 10th Anniversary Special Publication, |
|
Cheung
R.T.F., Convenor, Selected Topics of
Current Clinical Practice – Stroke & Cardiovascular Risk Management,
Association of Private Medical Specialists of Hong Kong, Ballroom, Langham
Hotel, Tsimshatsui, |
|
Cheung
R.T.F., Diagnosis and Management of Migraine,
Continued Medical Education Programme, Department of Anaesthesiology, |
|
Cheung
R.T.F., Diagnosis and Management of Migraine,
Hong Kong Pain Society Healthcare Education Events 2007, |
|
Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2008. |
|
Cheung R.T.F., Editorial Board, MIMS Neurology & Psychiatry Guide, Second Edition. Medimedia Asia, 2007. |
|
Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2007. |
|
Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2008. |
|
Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2008. |
|
Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2008. |
|
Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2008. |
|
Cheung
R.T.F., Editorial Comment, 編者的話, 戰勝中風症, |
|
Cheung R.T.F., Endocannabinoid System and Cardiovascular Risk, Symposium VIII, Third International Symposium on Healthy Aging, Research Centre of Heart, Brain, Hormone and Healthy Aging. 2008. |
|
Cheung
R.T.F., Endocannabinoid system and
cardiovascular risk, Third International Symposium on Healthy Aging:
Improving the Health of an Aging Population. |
|
Cheung
R.T.F., Foreword, MIMS Neurology &
Psychiatry Guide ( |
|
Cheung
R.T.F., International Advisory Committee
Member, Plenary Session Chairman, The 5th Asia Pacific Conference Against
Stroke (APCAS 2008), |
|
Cheung R.T.F., Managing Lipids for Stroke Prevention, Scientific Symposium 2 on Risk Factors and Stroke Prevention, 4th Asia Pacific Conference Against Stroke, Crown Plaza Hotel, Manila, Philippines. 2008. |
|
Cheung R.T.F., Managing lipids for stroke prevention, The Philippine Journal of Neurology. Philippine, 2008, 11 [Suppl 1]: 14-15. |
|
Cheung R.T.F., Melatonin and cerebrovascular disease, In: Pandi-Perumal SR, Cardinali DP, Melatonin: from Molecules to Therapy. Nova Publishers, 2007. |
|
Cheung R.T.F., Moderator, The 2007 Annual Scientific Meeting, The Hong Kong Pain Society Limited, Sheraton Hong Kong Hotel & Tower, Tsimshatsui. 2007. |
|
Cheung R.T.F., Organizing Committee Member & Chairman of Stroke Symposium, The 2007 Annual Scientific Meeting, The Hong Kong Neurological Society Limited, Kowloon Shangri-La Hotel, Tsimshatsui. 2007. |
|
Cheung R.T.F., Organizing Committee Member, Session Chairman, The 13th Medical Research Conference, Department of Medicine, HKU, LT1, Faculty of Medicine Building. 2008. |
|
Cheung R.T.F., Program Coordinator & Moderator, Joint Sichuan – Hong Kong Neurology Forum, The Hong Kong Neurological Society Limited & West China Hospital of Sichuan University, Sheraton Resorts, Jiuzhaigou, Sichuan, China. 2007. |
|
Cheung R.T.F., Stroke & Rehabilitation, Clinical Teaching in Integrative Medicine for TCM Graduates, Cardio/Cerebro Vascular Diseases & Rehabilitation (Hypertension & Stroke) PBL and Case Study, HAHO. 2007. |
|
Cheung
R.T.F., Stroke Prevention, The
Twenty-eighth Members’ Meeting, Worldwide Chinese Investors Association, The
Racing Club, Hong Kong Jockey Club, |
|
Cheung R.T.F., Stroke – Causes, Prevention & Management, Public Lecture Series, Health Commission of Medical Students’ Union, University of Hong Kong Students Union, St. James’s Settlement. 2008. |
|
Cheung R.T.F., Stroke, Public Lecture for 2008 Stroke Awareness Week of Hong Kong, Hong Kong Stroke Society, Hong Kong Neurological Society, Hong Kong Stroke Association, Jointpublishing Ltd & HK ET Press. 2008. |
|
Cheung
R.T.F., The use of fMRI in directing
acupuncture treatment – Stroke rehabilitation, Symposium of Global
Development on Chinese Medicine Proceedings. |
|
Cheung R.T.F., Update of lipid management for ischaemic stroke prevention, First Scientific Session, Second Quarterly Scientific Meeting of Hong Kong Stroke Society, Seminar Room 1, M/F, HAHO. 2008. |
|
Cheung
R.T.F., Update on Stroke Prevention, 51st
Anniversary Scientific Program: Advances in Clinical Medicine, The Society of
Physicians of Hong Kong, The Langham Hotel, |
|
Cheung R.T.F., Update on medical and surgical management of intracerebral hemorrhage, Reviews on Recent Clinical Trials. 2007, 2: 174-181. |
|
Cheung
R.T.F., Update on stroke prevention, 51st
Anniversary Scientific Program: Advances in Clinical Medicine, The |
|
Cheung
R.T.F., Use of Functional MRI in Guiding
Acupuncture, Update on Brain Disorders, |
|
Cheung R.T.F., Visiting Lecturer, Joint Final Master of Medicine (Internal Medicine) / MRCP (UK) PACES Examination Preparatory Course, National University of Singapore. 2008. |
|
Cheung R.T.F., Welcome Address, 10th International Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy. 2008. |
|
Cheung
R.T.F., 戰勝中風症, |
|
Chow E.H.C., Li J.T.T., So R.H.Y. and Cheung R.T.F., The effects of visual
stimulus oscillation frequency on postural disturbance in roll and in
fore-and-aft direction, Proceedings of VIMS 2007. |
|
Gao
J., Lee T.M.C., Chan Y.S., Chu L.W. and Cheung R.T.F., Cognitive assessments
of prospective memory and arrowhead tasks in patients with mild Alzheimer’s
disease and in healthy elderly, Third International Symposium on Healthy
Aging - Improving the Health of an Aging Population: 44. March 1-2. |
|
Ji J.T.T., Chow E., Lor F., So R.H.Y., Cheung R.T.F., Stanney K. and
Howarth P., A biologically inspired computational model relating vection and
visually induced motion sickness: individual differences and sensitivity
analysis, Proceedings of VIMS 2007. |
|
Lee A.C.K., Tang S.W., Yu G.K.K. and Cheung R.T.F., The incidence and predictors of Depression After Stroke. , International Journal of Psychiatry in Clinical Practice.. 2007, 11: 200-206. |
|
So R.H.Y., Cheung R.T.F., Chow E.H.C., Li J.T.T. and Lam A.K.C., Final Program and Proceedings, The First International Symposium on Visually Induced Motion Sickness, Fatigue, and Photosensitive Epileptic Seizure. 12/2007, 2007, 1-200. |
|
Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., Neurology in Practice 4th edition , Hong Kong, Hong Kong University Press, 2008, In press. |
|
Researcher
: Cheung RV |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Researcher
: Cheung TK |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Cheung T.K., Lam B., Ip M.S.M., Kung R., Ng C.Y.C. and Wong B.C.Y., Gastro-esophageal reflux disease negatively impacted on asthma control, quality of life and psychological status in Chinese asthma patients, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Cheung T.K. and Wong B.C.Y., Gastro-oesophageal Reflux Disease In Asia : Birth Of A 'new' Disease? , Drugs. 2008, 68(4): 399-406. |
|
Cheung T.K., Lim P.W. and Wong B.C.Y., Noncardiac Chest Pain-An Asia-Pacific Survey on the Role of the Cardiologist., J Clin Gastroenterol. . 2008, Epub ahead of print. |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Cheung
T.K., Lim P.W. and Wong B.C.Y., The view of
gastroenterologists on non-cardiac chest pain in |
|
Cheung T.K. and Wong B.C.Y., Treatment Of Helicobacter Pylori And Prevention Of Gastric Cancer., J Dig Dis.. 2008, 9(1): 8-13. |
|
Fung J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management, American Journal of Gastroenterology. 2008, 103: 1421-1426. |
|
Fung
J.Y.Y., Lai C.L., But D., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis
in chronic hepatitis B: implications for treatment and management, Hepatology.
2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, The
58th Annual Meeting of the American Association of the Study of Liver
Diseases, Boston, USA. 2007, |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Wong
B.C.Y. and Cheung T.K.,
Approach to the patient with gastrointestinal and liver disease, In: Wang JY,
Wong BCY, Textbook of Internal Medicine.. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yee Y.K., Cheung T.K., Chan A.O.O., Yuen R.M.F. and Wong B.C.Y., Decreasing Trend Of Esophageal
Adenocarcinoma In |
|
Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
|
Researcher
: Cheung WMW |
|
List of Research Outputs |
|
Fan
N.Y., Cheung W.M.W. and Kung A.W.C., Protein Kinase D Is an
Essential Mediator During Osteoblast Differentiation, 29th Annual Meeting
of the American Society for Bone and Mineral Research, |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease gene identification strategy, 57th Annual Meeting of The American Society of Human Genetics. 2007, 80(suppl): T2119. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease-gene identification strategy, J Hum Genet. 2008, 53: 644-655. |
|
Researcher
: Chim JCS |
|
List of Research Outputs |
|
Chan V.N.Y., Chan J., Chim J.C.S., Ooi C.G.C. and Chan T.K., Iron overload in Hb H disease, Fourth International Eijkman Conference, Bali, Indonesia, November 15-18. 2007. |
|
Chim J.C.S., 全港首宗輸血染菌, Apple Daily News. 2008. |
|
Chim J.C.S. and Wong L.G., Deafness associated with the use of Bortezomib in multiple myeloma, Acta Oncologica. 2008, 47(2): 232-4. |
|
Chim
J.C.S., Defeating Leukaemia and Multiple
Myeloma, 治療骨髓癌及白血病新知 , 1st series of Public
Lecture Series 2008, The |
|
Chim
J.C.S., Emerging concepts in the management
of multiple myeloma, Centro Hospitalar Conde de S. Januario, |
|
Chim
J.C.S., Epigenetic alterations in haemic
cancers, Cancer Centre, The |
|
Chim J.C.S., Epigenetic alterations in the pathogenesis of multiple myeloma , Hong Kong International Cancer Congress . 2007. |
|
Chim J.C.S., Pang R.W.C., Fung T.K., Choi C.L. and Liang R.H.S., Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma, Leukemia. 2007, 21: 2527–2536. |
|
Chim J.C.S., Essential Thrombocythemia: risk factors to thrombosis, bleeding myelofibrosis and leukemia , 南方醫科大學珠江醫院 , 2008. |
|
Chim J.C.S., Experience of Complete Remission and update on ATOM trial in multiple myeloma, Hong Kong Society of Haematology, Sheraton Hotel. 2007. |
|
Chim
J.C.S., Fellow of the |
|
Chim
J.C.S., Wong
K.Y., Loong F., Lam W.W. and Srivastava G., Frequent epigenetic
inactivation of Rb |
|
Chim
J.C.S., Wong
K.Y., Loong F., Lam W.W. and Srivastava G., Frequent epigenetic
inactivation of Rb |
|
Chim
J.C.S., Impact of allogeneic bone marrow
transplantation in adult ALL , |
|
Chim
J.C.S., Multiple myeloma in |
|
Chim
J.C.S., PUO : Catastrophic anti-phospholipid
antibody syndrome, Grand Rounds, University Department of Medicine, |
|
Chim J.C.S., Yiu C.P.B. and Shek T.W.H., Pathological bone fracture in non-Hodgkin's lymphoma, Journal of Clinical Oncology. 2007, 25(21): 3175-6. |
|
Chim J.C.S., Pollution a risk factor in blood clots, study finds, South China Morning Post. 2008. |
|
Chim J.C.S., Wong M.A.T.T.H.E.W. and Fan P.Y.S., Pulmonary interstitial amyloidosis complicating multiple myeloma, Journal Clinical Oncology: official Journal of the American Society of Clinical Oncology. 2008, 26(3): 504-6. |
|
Chim J.C.S., Rapid complete remission in multiple myeloma with bortezomib/thalidomide/dexamethasone combination therapy following development of tumor lysis syndrome, Cancer Chemotherapy & Pharmacology. 2008, 62(1): 181-2. |
|
Chim J.C.S., 標靶治療血癌痊愈率高, Sing Pao Daily News. 2008. |
|
Chim J.C.S., Targeted therapy in Haemic malignancies , Annual Scientific Meeting of the Federation of Medical Societies of Hong Kong . 2007. |
|
Chim
J.C.S., The |
|
Chim J.C.S., The Open Pathology Journal. 2008. |
|
Chim J.C.S., The Open Surgical Oncology Journal. 2008. |
|
Fan Y.S., Ng W.K., Chan A., Chan G.S., Tsang J., Chim J.C.S. and Ip P., Fine needle aspiration cytology in follicular dendritic cell sarcoma: a report of two cases, Acta cytologica. 2007, 51(4): 642-647. |
|
Hwang Y.Y., Chim J.C.S., Chan G., Loong F. and Yau T., Breast and pelvic
masses in a myeloma patient, Annals of Hematology. Springer |
|
Hwang Y.Y., Chim J.C.S. and Shek T.W.H., Multiple myeloma with testicular involvement, Journal of Clinical Oncology: official Journal of the American Society of Clinical Oncology. 2008, 26(9): 1558-9. |
|
Researcher
: Choi CL |
|
List of Research Outputs |
|
Chim J.C.S., Pang R.W.C., Fung T.K., Choi C.L. and Liang R.H.S., Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma, Leukemia. 2007, 21: 2527–2536. |
|
Researcher
: Chow WH |
|
List of Research Outputs |
|
Chau M.C., Chow W.H., Wang E. and Kwong Y.L., Cardiac amyloidosis - experience in a tertiary cardiac referral centre, International journal of cardiology. 2008, 124(2): 264-6. |
|
Researcher
: Chow WS |
|
List of Research Outputs |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Tam H.L., Shiu S.W.M., Chow W.S., Wong Y. and Tan K.C.B., Effect of atorvastatin on serum soluble receptor for advanced glycation end products in type 2 diabetes, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Tan K.C.B., Shiu S.W.M., Chow W.S., Leng L., Bucala R. and Betteridge D.J., Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 49: 2756-62. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Tso A.W.K., Xu A., Chow W.S. and Lam K.S.L., Adipose tissue and the metabolic syndrome: focusing on adiponectin and several novel adipokines, Biomarkers in Medicine. 2008, 2: 239-52. |
|
Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
|
List of Research Outputs |
|
Yang J., Khong P.L., Wang Y., Chu A.C.Y., Ho S.L., Cheung P.T. and Wu E.X., Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury, Magnetic Resonance in Medicine. 2008, 59: 1329. |
|
Project Title: |
A dementia outreach programme in Central, Western and Southern districts of Hong Kong |
|
Investigator(s): |
|
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To achieve early detection of dementia, through an outreach dementia-screening programme. |
|
List of Research Outputs |
|
Chu L.W., Li Y., Tang A.Y.B., Cheung B.M.Y., Leung Y.H., Yik P.Y., Jin D. and Song Y., A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer' s disease in Chinese, Am J Med Genet B. 2007, 144(8): 1007-13. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
|
Chu L.W., Tam S., Kung A.W.C., Lo S., Fan S., Wong L.C., Morley J.E. and Lam K.S.L., Serum total and bioavailable testosterone levels, central obestiy and muscle strength changes with aging in healthy Chinese men, Journal of American Geriatrics Society. 2008, 56(7): 1286-1291. |
|
Gao
J., Lee T.M.C., Chan Y.S., Chu L.W. and Cheung R.T.F., Cognitive assessments of
prospective memory and arrowhead tasks in patients with mild Alzheimer’s
disease and in healthy elderly, Third International Symposium on Healthy
Aging - Improving the Health of an Aging Population: 44. March 1-2. |
|
Lee A.M., Lam T.P., Chong C.S.Y., Chu L.W. and Chan S.Y., A study of androgen deficiency and its relationship with psychological factors in Hong Kong, Poster presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007. |
|
List of Research Outputs |
|
Chu
Y.W., McManus
A.M. and Yu C.W., Calibration Of
The Rt3 Accelerometer For Ambulation And Nonambulation In Children, Medicine
And Science In Sports And Exercise. |
|
Chu Y.W., McManus A.M. and Hu Y., Short-duration patterning of physical activity and biomechanical walking efficiency in lean and overweight children., Short-duration patterning of physical activity and biomechanical walking efficiency in lean and overweight children.. 2007. |
|
Chu
Y.W., The Role Of Traditional Chinese
Medicine In Bone Fracture Healing, The City |
|
Chu
Y.W., McManus
A.M. and Hu Y., The Young
Investigator Award (Short-duration Patterning Of Physical Activity And
Biomechanical Walking Efficiency In Lean And Overweight Children), The
24th Pediatric Work Physiology Meeting (Children And Exercise) XXIV, |
|
Researcher
: Chung ACK |
|
Project Title: |
Involvement of PPAR interacting protein (PRIP) in the kidney complication during diabletic nephropathy |
|
Investigator(s): |
Chung ACK, Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
Diabetes nephropathy (DN) is the leading cause of end stage renal failure (ESRF) and a major complication of diabetes (1). It results in significant morbidity as well as social and economic costs to the community. Peroxisome proliferator-activated receptor (PPAR) agonists have recently been used to cure DN (2) although the means by which this is achieved remains unclear. In addition, major drawbacks of PPAR agonists include hepatotoxicity and fluid retention. Further studies should be performed to search for an alternative therapeutic agent that demonstrates similar benefit to renal function without severe adverse effects. PPARs are members of the nuclear receptor superfamily of ligand-binding transcription factors (3,4). The principal function of three subtypes of this receptor that are differentially expressed in kidneys, PPAR-α, -β, -γ, is to control metabolic mechanisms (3,5). In diabetic kidneys, PPAR-α expression is elevated in the glomeruli, cortical tubules, and renal arterial vessels but mice lacking PPAR-α develop accelerated DN (6,7). The detailed function of PPARs in the kidney is still unclear. After binding to a ligand, PPARs form heterodimers with retinoid X receptor alpha (RXRα) (Fig. 1) (4). These PPAR:RXRα heterodimers bind to a specific DNA motif, PPRE, in the promoter region of target genes to activate gene transcription. Evidence indicates that transcriptional activation of nuclear receptors after ligand binding involves the participation of coactivators (8). These coactivators are recruited to PPAR:RXRα heterodimers to modulate the transcriptional activity of PPAR by remodeling chromatin and establishing physical contact with basal transcriptional initiation machinery (8). Thus the expression of PPAR, availability of PPAR ligands, and presence of coactivators will contribute to the biologic effects of PPAR activity. After PPAR-interacting protein (PRIP) was initially cloned using PPARγ as bait in the yeast two-hybrid system (9), PRIP (otherwise referred to as ASC-2, AIB3, RAP250, NRC, TRBP, or NcoA6) was characterized as a strong transcriptional coactivator for PPAR-α, PPAR-γ, RXRα, ER, and TRβ1 (9,11). PRIP can also bind to basal transcriptional factors TBP and TFIIA (11) and may thus function through bridging the nuclear receptors to the basal transcriptional factors. Noticeably, PRIP is required for proper function of PPAR-γ: mice that lack either PPAR-γ or PRIP die at a similar age (embryonic day 9.5 to 11.5) and possess similar placental phenotypes (12,14). PRIP binds to PPAR-γ through one of its nuclear receptor binding motifs, LXXLL and can potentiate the transcriptional activities of PPAR-γ in mammalian cells (9). In mouse embryonic fibroblast (MEF) cells, inactivation of the PRIP gene significantly attenuates PPAR-γ transcriptional activity (12,14,15). Therefore the presence of PRIP is essential for PPAR-γ transcriptional activation. In the kidney, PRIP is strongly expressed in proximal and distal convoluted tubules in the cortex (16): expression is significantly reduced in the diabetic kidney of the KK/Ta mouse model of type 2 diabetes (17). This suggests that, although not yet proven, the presence of PRIP may play a role in DN. In our preliminary study by the realtime RT-PCR analyses (Fig. 2), PRIP expression in WT MEF cells was significantly decreased after the MEF cells was treated with advanced glycation end (AGE) for 12 hours to develop a DN condition, suggesting that PRIP may play a role in DN. The expression levels of fibrosis-related genes, such as collagan-I, MCP-1, and TNF-α, were also upregulated (Fig. 2), suggesting TGF-β related fibrosis may occur. Loss of PRIP function in MEF cells is able to upregulate more smad3, collagan-I, IL-8, MCP-1, and TNF-α expression (Fig. 2), suggesting fibrosis becomes more severe. These results support the speculation that loss of PRIP function should resemble the mice deficiency of PPAR-α gene in which DN is accelerated. Based on these preliminary observations, our hypothesis is as follows (Fig. 3): In the normal kidney, PRIP coactivates PPAR to control the TGF-β function in the repair of acute injury. In the presence of diabetes, AGE products or high glucose (HG) will induce TGF-β function on fibrosis. AGE or HG may reduce PRIP expression by the kidney and this reduction may impede PPAR function on TGF-β induced fibrosis with resultant DN. During treatment, PPAR agonists can activate PPAR function to suppress DN. Studies on the role of PRIP in DN should clarify and clearly establish the therapeutic role of PRIP in diabetic disease states, and benefit the understanding of DN. The objective of this study is to determine the specific role of PRIP in DN under HG and AGE products by in vitro cell culture approach. This will be achieved by the execution of the two following specific aims: 1. To characterize the specific role of PRIP in MEF cells under DN condition 2. To characterize the specific role of PRIP in kidney cells under DN condition. Ultimately, this study will enable us to explore the new role and novel mechanisms of PRIP in DN, and may provide new information that will aid in the design of a novel therapy for DN. |
|
List of Research Outputs |
|
Chung A.C.K., Lan X.R., Zhou L., Heuchel R. and Lan H.Y., Loss of Smad7 Promotes Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 11th Asian Pacific Congress of Nephrology. 2008. |
|
Chung
A.C.K., Lan
X.R., Zhou L. and Lan H.Y., Loss of Smad7 Promotes Renal
Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 13th
Medical Research Conference of Department of Medicine ( |
|
Lan X.R., Chung A.C.K., Wang X.J., Lai K.N. and Lan H.Y., Mice Overexpressing Latent TGF-{beta}1 Are Protected against Renal Fibrosis in Obstructive Kidney Disease., American journal of physiology. Renal physiology. 2008, 295: F118-27. |
|
Lan X.R., Chung A.C.K., Zhou L., Li A.G., Wang X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis., 43th Annual Meeting Of Australian New Zealand Society Of Nephrology, Gold Coast, Australia (8-12 Sep, 2007). 2007. |
|
Lan X.R., Chung A.C.K., Zhou L., Wong X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis, Journal Of American Society Of Nephrology. 2008, 19: 233-242. |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective Role Of Latent
Tgf-beta |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective role of latent
Transformating Growth Factor-beta |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Angiotensin II Induces
Epithelial-Mesenchymal Transition (EMT) via the TGF-beta/Smad3-Dependent and
ERK/p38 MAP Kinase-Smad3 Crosstalk Pathways: Essential Role of Smad3, 13th
Medical Research Conference of Department of Medicine ( |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Signaling Mechanisms of
Angiotensin II-Induced EMT in Tubular Epithelial Cells, The 12th Research
Postgraduate Symposium, HKU, 12- |
|
Researcher
: Chung SSM |
|
Project Title: |
Osmoregulation in lens |
|
Investigator(s): |
Chung SSM |
|
Department: |
|
|
Source(s) of Funding: |
Outstanding RGC Projects |
|
Start Date: |
09/1998 |
|
Abstract: |
|
It is imperative to have a better understanding of the mechanisms leading to various cataracts such that preventive measures can be developed. Since maintaining the ionic strength and ionic composition in the lens is essential for the transparency of the lens, we plan to study the mechanism of osmoregulation in this organ. Transgenic mice that over-express aldose reductase and sodium dependent myoinositol transporter in their lenses will be used to increase the lens' level of sorbitol and myoinositol, respectively. We will determine if high level of these osmolytes causes cataract development, and see when the level of one osmolyte is high, will the lens compensate by reducing the level of other osmolytes. We will also determine whether high intracellular osmotic pressure affects the regulation of expression of genes that control the level of osmolytes such as aldose reductase, sodium dependent myoinositol transporter, and taurine transporter. |
|
Project Title: |
Effects of early postnatal feeding on fatty acid metabolism |
|
Investigator(s): |
Chung SSM, Sheng HP |
|
Department: |
|
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2002 |
|
Abstract: |
|
Both epidemiological studies and animal studies have shown that prenatal and early postnatal nutrition not only affects infant growth and development, it also predetermines future metabolism, performance adn morbidity. This study addresses the problems of nutritional environment during the sucking period on lipid metabolism and later-life obesity. |
|
Project Title: |
Polyol pathway in diabetic dyslipidemia |
|
Investigator(s): |
Chung SSM |
|
Department: |
|
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To determine if AR null mutation reduces plasma TG levels in diabetic mice; to determine if ARI reduces plasma TG in diabetic mice; to determine if AR null mutation or ARI nor ARI normalizes LDL and HDL leviabetic mice. |
|
Project Title: |
Mechanism of Nogo-A inhibition of axonal regeneration |
|
Investigator(s): |
Chung SSM, Chung SK |
|
Department: |
|
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To develop Nogo gene knockout mice to determine the role of this gene in the inhibition of axonal regeneration and its physiological functions; to develop transgenic mice that overexpress Nogo-A in their Schwann cells to determine if that would make their PNS non-permissive for axonal regeneraton; to develop transgenic mice that overexpress mutant Nogo-A with the Nogo-66 or aa623-640 region deleted to determine which domain is responsible for the inhibitory effect of Nogo-A. |
|
Project Title: |
The polyol pathway as a thrifty pathway promoting energy storage |
|
Investigator(s): |
Chung SSM |
|
Department: |
Physiology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To determine the in vivo conversion of glucose to fatty acids and triglycerides in normal mice and mice deficient in AR; to determine if AR deficiency affects the activities of lipogenic/adipogenic transcriptional factors including ADD1/SREBP-1 and CHOP-C/EBP-[alpha], anti-obesity transcriptional factor FOXC2, and enzymes fatty acid synthase (FAS) and stearoyl CoA desaturase (SCD); to assess whether administration of inhibitors of aldose reductase (ARI) will affect obesity and improve glucose tolerance in the agouti yellow mice; to determine whether the effects of aldose reductase deficiency on agouti-induced lipogenesis and obesity can be duplicated in diet-induced obesity models. |
|
Project Title: |
Aldose reductase in diabetic cataract |
|
Investigator(s): |
Chung SSM |
|
Department: |
|
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To determine if the antioxidant can prevent AR-induced slow-developing cataract; to determine the osmolyte content and oxidative status of the slow-developing cataract; to compare the morphological changes in the acute diabetic cataract and the slow developing cataract; to determine if there is apoptosis in the epithelial cells of the precataractous lenses. |
|
Researcher
: Dai Y |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
|
Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Researcher
: Dai Z |
|
List of Research Outputs |
|
Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
|
Researcher
: Deng X |
|
List of Research Outputs |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Researcher
: Dong M |
|
List of Research Outputs |
|
Tang Q., Jin M.W., Xiang J.Z., Dong M., Sun H., Lau C.P. and Li G.R., The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. , Biochem Pharmacol. 2007, 74(11): 1596-607. |
|
Researcher
: Eddy AA |
|
List of Research Outputs |
|
Tang S.C.W., Leung J.C.K., Chan L.Y., Eddy A.A. and Lai K.N., ACEi suppresses angiotensin II-induced MAPK activation and TGF-β secretion in cultured PTEC, Proceedings of The World Congress of Nephrology. 2007, 368. |
|
Researcher
: Epstein R |
|
Project Title: |
Evolutionarily conserved patterns of synonymous codon bias in wild-type orthologous and paralogous gene sequences, and comparison with patterns of bias in human tumour genomes |
|
Investigator(s): |
Epstein R |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding for New Staff |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To clarify whether these evident associations of synonymous codon bias with function and/or with methylation are interdependent or independent. |
|
Project Title: |
Environmental and therapeutic modulation of tumour suppressor gene methylation |
|
Investigator(s): |
Epstein R, Smith DK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
Lifestyle changes in |
|
List of Research Outputs |
|
Campone M., |
|
Epstein R., Best Presentation, 6th Asia-Pacific Bioinformatics Conference. 2008. |
|
Epstein R., Clinical use of VEGF signal inhibitors., Plenary Lecture 12th Annual Scientific Symposium, Hong Kong Cancer Institute, Prince of Wales Hospital, Shatin. 2007. |
|
Epstein R., Growth of the Asian health-care market: global implications for the pharmaceutical industry, Nature Reviews Drug Discovery. 2007, 6: 785-92. |
|
Epstein R. and Cheung B.M.Y., Loading doses for costly cancer biologicals: sound pharmacology or unnecessary extravagance? , Eur J Cancer. 2008, 44(11): 1488-92. |
|
Epstein
R., Molecular evolution of tumour suppressor
genes. , XIV Hong Kong International Cancer Congress, The |
|
Epstein R., Symposium Chairman: Advances in colorectal cancer drug therapy. , Sanofi-Aventis Asian Oncology Conference . 2007. |
|
Epstein
R., Target-specifc anticancer therapy:
overview and application to breast cancer. , Plenary Lecutre, |
|
Epstein R. and Leung T.W.T., Tumor resensitization to erlotinib following brief substitution of cetuximab., Cancer Chemother Pharmacol. 2008. |
|
Epstein R., VEGF signaling inhibitors: More pro-apoptotic than anti-angiogenic, Cancer Metastasis Rev. 2007, 26: 443-52. |
|
Hsu C., Yang T., Toh H. and Epstein R., Phase II study of
bevacizumab plus capecitabine in patients with advanced hepatocellular
carcinoma: final report. , Proc ASCO 2008, |
|
Tang S.M. and Epstein R., A structural split in the human genome, PLoS ONE. 2007, 2(7): e603. |
|
Tang
S.M. and Epstein R.,
Divergent roles of intron size and intron number in genetic evolution. , The
Sixth Asia-Pacific Bioinformatics Conference, |
|
Yau T., Chan P., Wong H., Ng K.K.C., Chok K.S.H., Cheung T.T., Lam V.W.T., Epstein R., Fan S.T. and Poon R.T.P., Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma, Oncology. 2007, 72 Suppl 1: 67-71. |
|
Yau T., Chan P., Chan Y., Wong B.C.Y., Liang R.H.S. and Epstein R., Review article: current management of metastatic colorectal cancer - the evolving impact of targeted drug therapies. , Aliment Pharmacol Ther. 2008, 27(11): 997-1005. |
|
Yau T.C., Chan P., Chan R., Wong B.C.Y., Liang R.H.S. and Epstein R., Current management of metastatic colorectal cancer: the evolving impact of targeted drug therapies., Aliment Pharm Ther. 2008, 27: 997-1005. |
|
List of Research Outputs |
|
Fan
N.Y., Cheung
W.M.W. and Kung A.W.C., Protein
Kinase D Is an Essential Mediator During Osteoblast Differentiation, 29th
Annual Meeting of the American Society for Bone and Mineral Research, |
|
Researcher
: Fong CY |
|
List of Research Outputs |
|
Chan K.H., Tsang K.L., Fong C.Y., Mak W. and Ho S.L., Clinical Outcome Of Relapsing Remitting Multiple Sclerosis In Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Fong C.Y., Kwan P., Hui A.C.F., Lui C.H.T., Fong K.Y. and Wong V.C.N., An epidemiological study of epilepsy in Hong Kong SAR, China, Seizure. 2008, 17: 457-464. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Researcher
: Fong HY |
|
List of Research Outputs |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Lam
K.S.L., Wat N.M.S., Tso A.W.K., Fong H.Y. and Xu A., Additive effects of adiponectin
and C-reactive protein in predicting the risk of type 2 diabetes: a 10-year
prospective study. , 43rd Annual Meeting of the EASD,17-21 September 2007,
|
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Yeung C.Y., Xu A., Cheung C.W.S., Wat N.M.S., Yau J.M.H., Fong H.Y., Chau M.T. and Lam K.S.L., Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology.. US, American Heart Association, 2007, 27: 1796-1802. |
|
List of Research Outputs |
|
Fong C.Y., Kwan P., Hui A.C.F., Lui C.H.T., Fong K.Y. and Wong V.C.N., An epidemiological study of epilepsy in Hong Kong SAR, China, Seizure. 2008, 17: 457-464. |
|
Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., Neurology in Practice 4th edition , Hong Kong, Hong Kong University Press, 2008, In press. |
|
Researcher
: Fung FKC |
|
List of Research Outputs |
|
Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Researcher
: Fung JYY |
|
List of Research Outputs |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Fung J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis, Liver International. 2008. |
|
Fung
J.Y.Y., Current Treatment Recommendations for
Chronic Hepatitis B, |
|
Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
|
Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
|
Fung J.Y.Y., Yuen R.M.F., Yuen J.C.H., Wong D.K.H. and Lai C.L., Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study. , Aliment Pharmacol Ther. 2007, 26: 377-382. |
|
Fung
J.Y.Y., Lai
C.L. and Yuen R.M.F., New
paradigms for the treatment of chronic hepatitis B, Journal
of Gastroenterology and Hepatology. 2008, 23( |
|
Fung
J.Y.Y., Lai
C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, Hepatology. 2007, 6(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai
C.L., Fong D.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management, American Journal of Gastroenterology. 2008, 103: 1421-1426. |
|
Fung
J.Y.Y., Lai
C.L., But D., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, Hepatology.
2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai
C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, The
58th Annual Meeting of the American Association of the Study of Liver
Diseases, Boston, USA. 2007, |
|
Fung
J.Y.Y., Lai
C.L., Tanaka Y., Mizokami M., Yuen
J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT
and HBeAG status after stopping lamivudine in patients with HBeAg
seroconversion, Hepatology. 2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai
C.L., Tanaka Y., Mizokami M., Yuen
J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT,
and HBeAg status after stopping lamivudine in patients with HBeAg
seroconversion, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Significance of HBeAg seroconversion in patients with genotype B & C, International Liver Congress. 2008. |
|
Fung J.Y.Y., Transient Elastography in Clinical Practice, International Liver Congress 2008. 2008. |
|
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment of Chronic Hepatitis C with Different Genotypes, In: Emilio Jirrilo, Hepatitis C Virus Disease. Springer, 2007. |
|
Fung K.T.T., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Etiologies of chronic liver diseases in Hong Kong, Eur J Gastroen Hepat. 2007, 19(8): 659-64. |
|
Hung I.F.N., Poon R.T.P., Lai C.L., Fung J.Y.Y., Fan S.T. and Yuen R.M.F., Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection., American Journal of Gastroenterology. 2008, 103(7): 1663-1673. |
|
Lai
C.L., Fung J.Y.Y. and Yuen R.M.F., Updates in the Treatment of
Chronic Hepatitis B., The |
|
Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Updates in the treatment of chronic hepatitis B, The Hong Kong Medical Diary. 2008, 13: 15-19. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S375. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S375. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B Virus Core-related Antigens as a Marker for Monitoring of Chronic Hepatitis B Infection, Journal of Clinical Microbiology. 2007, 45: 3942-3947. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B virus core-related antigens as a marker for monitoring of chronic hepatitis B infection., J Clin Microbiol . 2007, 45(12): 3942-7. |
|
Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
|
Yuen R.M.F., Fong D.Y.T., Wong D.K.H., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response, Hepatology. 2007, 46: 1695-1703. |
|
Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
|
Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels, Gut. 2008, 57(1): 98-102. |
|
Researcher
: Fung PCW |
|
Project Title: |
Development of a novel natural antioxidant with strong anti-aging and protective properties for skin |
|
Investigator(s): |
Fung PCW, Shen J |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
|
Start Date: |
07/2002 |
|
Abstract: |
|
To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin. |
|
Project Title: |
Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke |
|
Investigator(s): |
Fung PCW, Shen J |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke. |
|
Project Title: |
High level brain activity studies and applications |
|
Investigator(s): |
Fung PCW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2004 |
|
Abstract: |
|
To better understand and utilize the functioning of the brain. |
|
List of Research Outputs |
|
Chang
C., Ding Z., Hung Y.S. and Fung P.C.W., Fast network component
analysis (FastNCA) for gene regulatory network reconstruction from microarray
data, Bioinformatics. |
|
Chang
C., Ding Z., Hung Y.S. and Fung P.C.W., Fast network component
analysis for gene regulation networks, IEEE International Workshop on
Machine Learning for Signal Processing. |
|
Chang C., Fung P.C.W. and Hung Y.S., Improved Gene Prediction by Resampling-based Spectral Analysis of DNA Sequence, 5th International Conference on Information Technology and Application in Biomedicine (ITAB 2008). 2008. |
|
Mok
T.M.Y., Fung P.C.W., Ooi
C., Tse H.F., Wong Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
|
Ren J., Fung P.C.W., Chang C., Shen G.G., Chan F.H.Y., Liu K.J. and Shen J., A comparative ESR study on blood and tissue nitric oxide concentration during renal ischemia-reperfusion injury , Applied Magnetic Resonance. Springer-Verlag, 2007, 32: 243-255. |
|
Xu W.,
Chang C., Hung Y.S. and Fung P.C.W., Asymptotic Properties of
Order Statistics Correlation Coefficient in the |
|
Xu W., Chang C., Hung Y.S., Kwan S.K. and Fung P.C.W., Order statistics correlation coefficient as a novel association measurement with applications to biosignal analysis, IEEE Transactions on Signal Processing. IEEE, 2007, 55: 5552-5563. |
|
Xu W., Chang C., Hung Y.S. and Fung P.C.W., Quantifying organization during atrial fibrillation based on order statistics correlation coefficient, ITAB 2008/ISSSBHE2008. |
|
Researcher
: Fung TK |
|
List of Research Outputs |
|
Au W.Y., Leung R.Y.Y., Mok T., Fung T.K. and Liang R.H.S., Familial occurrence of sequential B-cell lymphoma and myeloproliferative disease , Annals of Hematology. 2008, Epub. |
|
Chim J.C.S., Pang R.W.C., Fung T.K., Choi C.L. and Liang R.H.S., Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma, Leukemia. 2007, 21: 2527–2536. |
|
Researcher
: Gao J |
|
List of Research Outputs |
|
Gao J.,
Lee T.M.C., Chan Y.S., Chu L.W. and Cheung R.T.F., Cognitive assessments of
prospective memory and arrowhead tasks in patients with mild Alzheimer’s
disease and in healthy elderly, Third International Symposium on Healthy
Aging - Improving the Health of an Aging Population: 44. March 1-2. |
|
Researcher
: Gu Q |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
|
Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Researcher
: Guo H |
|
List of Research Outputs |
|
Cheung S.C., Guo H., Leung J.C.K., Man K., Lai K.N. and Wu E.X., MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement, Magnetic Resonance in Medicine. 2008, 59: 1170-4. |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Researcher
: Ho AYY |
|
List of Research Outputs |
|
Kung A.W.C., Lee K.K., Ho A.Y.Y., Tang G.W.K. and Luk K.D.K., Ten-Year Risk of Osteoporotic Fractures in Postmenopausal Chinese Women According to Clinical Risk Factors and BMD T Scores: A Prospective Study, Journal of Bone and Mineral Research. 2007, 22: 1080-7. |
|
Researcher
: Ho JCM |
|
List of Research Outputs |
|
Ho J.C.M., Wang J., Wong M. and Lam W.K., A phase II study of vinorelbine monotherapy in the treatment of advanced non-small cell lung cancer in elderly Chinese population. 12th World Conference on Lung Cancer., Journal of Thoracic Oncology 2007;2(8) Suppl 4.. 2007, S675. |
|
Ho
J.C.M., Approach to a solitary pulmonary
nodule, In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory Medicine.
|
|
Ho J.C.M., Approach to patients with interstitial lung disease, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU, 23rd September. 2007. |
|
Ho J.C.M., Lam B., Ip M.S.M. and Lam W.K., Clinical Respiratory Medicine, 3rd edition, Hong Kong, 2007. |
|
Ho
J.C.M., Cryptogenic organizing pneumonia:
mimic with CAP, (invited overseas speaker) Critical Care and Lung Infection
Symposium 2008, |
|
Ho
J.C.M., Cryptogenic organizing pneumonia:
mimic with CAP, Critical Care and Lung Infection Symposium 2008. |
|
Ho J.C.M., Lo R.L.K., Lam W.K. and Kwong Y.L., Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., AJRCCM 2008;177(10) Suppl. 2008, A463. |
|
Ho J.C.M., HK: Panel Member for the Meeting, 25 Aug, NSCLC Diagnosis and Management Group, Pharma Frontiers . 2007. |
|
Ho J.C.M., Iternal Medicine (Respiratory Medicine) Panel Member for e-Knowledge Gateway, Hospital Authority (since 2008). 2008. |
|
Ho
J.C.M., Lessons from severe acute
respiratory syndrome (SARS): preparing for the next epidemic, (invited
overseas speaker) Critical Care and Lung Infection Symposium 2008, |
|
Ho
J.C.M., Lessons from severe acute respiratory
syndrome (SARS): preparing for the next epidemic, Critical Care and Lung
Infection Symposium 2008. |
|
Ho
J.C.M., Lunger cancer: the facts to know in
2007, Macau patient pulick talk, AstraZeneca, |
|
Ho J.C.M., Management of pleural diseases and pulmonary embolism, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU, 23rd September . 2007. |
|
Ho
J.C.M., Molecular targeting treatment in lung
cancer. Plenary IV-Advances in Treatment of Advanced Diseases, The William
and Elizabeth Davies Foundation Trust International Meeting 10th-11th May
2008. |
|
Ho J.C.M., Recent advances in the management of CA lung, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU, 23rd September. 2007. |
|
Ho J.C.M., Respiratory infections (II), Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU. 22nd September. 2007. |
|
Ho
J.C.M., Targeted therapy for lung cancer,
Public talk for |
|
Ho J.C.M., Targeted therapy for lung cancer, The Federation’s Annual Scientific Meeting 2007, Federation of Medical Societies of Hong Kong, 20th October. 2007. |
|
Ho J.C.M., Targeted therapy for lung cancer, Hong Kong Anti-Cancer Society. 2008. |
|
Ho
J.C.M., Targeted therapy for non-small
cell lung cancer,14th |
|
Lam D.C.L., Ho J.C.M. and Lam W.K., Carcinoma of the bronchus, In:
JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory Medicine. |
|
Lo R.L.K., Lam W.K., Kwong Y.L. and Ho J.C.M., Best poster - Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., 13th Medical Research Conference. 2008. |
|
Mak J.C.W., Ho S.P., Ho A.S.S., Law B.K., Ho J.C.M. and Chan M.M.W., Increased oxidative stress during acute asthma exacerbation in Hong Kong Chinese asthmatics, Pro Am Thorac Soc. 2008, 3: A472. |
|
Wong M.K., Wong M.P., Lam D.C., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2008. |
|
Wong M.K.Y. and Ho J.C.M., Diseases of the pleura,
In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory Medicine. |
|
Wong M.K.Y., Ho J.C.M. and Chan M.M.W., Interstitial and
occupational lung diseases, In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical
Respiratory Medicine. |
|
Wong M.K.Y., Pang C.B.Y. and Ho J.C.M., Respiratory
investigations, In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory
Medicine. |
|
Researcher
: Ho JCY |
|
List of Research Outputs |
|
Watts F.Z., Skilton A., Ho J.C.Y., Boyd L.K., Trickey M.A., Gardner L., Ogi F.X. and Outwin E.A., The role of Schizosaccharomyces pombe SUMO ligases in genome stability, Biochemical Society Transactions. 2007, 35: 1379-1384. |
|
Researcher
: Ho SL |
|
List of Research Outputs |
|
Chan K.H., Tsang K.L., Fong C.Y., Mak W. and Ho S.L., Clinical Outcome Of Relapsing Remitting Multiple Sclerosis In Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Ramsden D.B., Chu A.C.Y., Kwok H.H. and Ho S.L., NMO-IgG in idiopathic inflammatory demyelinating disorders in Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Chan K.H., Cheung R.T.F., Mak W. and Ho S.L., Nonthymoma early-onset and late-onset generalized myasthenia gravis - a retrospective hospital based study, Clinical Neurology and Neurosurgery. 2007, 109: 686-691. |
|
Ho
S.L., Associate Editor, In: In:
Editor-inchief: Professor Peter Lewitt, Clinical
Neuropharmacology. |
|
Ho
S.L., Neuroprotection in Parkinson’s disease,
Invited Speaker, International Movement Disorder Society CME &
Parkinson’s Disease Symposium, Shanghai, PR China. |
|
Ho
S.L., Neuroprotection in Parkinson’s disease,
Invited speaker and Co-chairman, 1st Asian & Oceanian Parkinson’s
Disease & Movement Disorders Congress (AOPMC) Singapore . |
|
Ho
S.L., Non-motor complications in Parkinson’s
disease, Invited speaker and Co-chairman , 6th International Symposium of
the Asian & Pacific Parkinsons Association (APPA) Singapore. |
|
Ho
S.L., Overview of movement disorders:
classification and phenomenology, Invited speaker and Co-chairman , 1st
Asian & Oceanian Parkinson’s Disease & Movement Disorders Congress
(AOPMC) Singapore. |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Li M., Jiang L., Ho S.L., Song Y. and Sham P.C., IGG: A tool to integrate GeneChips for genetic studies. , Bioinformatics. 2007, 23(22): 3105-3107. |
|
Li M., Ho S.L., Sham P.C. and Song Y., In Silico Mapping of a Charcot-marie-tooth Disease Gene in a Pedigree of Hong Kong Chinese, 12th Research Postgraduate Symposium, December 12 & 14, 2007. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Yang J., Khong P.L., Wang Y., Chu A.C.Y., Ho S.L., Cheung P.T. and Wu E.X., Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury, Magnetic Resonance in Medicine. 2008, 59: 1329. |
|
Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., Neurology in Practice 4th edition , Hong Kong, Hong Kong University Press, 2008, In press. |
|
Researcher
: Ho SP |
|
List of Research Outputs |
|
Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
|
Mak J.C.W., Ho S.P., Ho A.S.S., Law B.K., Ho J.C.M. and Chan M.M.W., Increased oxidative stress during acute asthma exacerbation in Hong Kong Chinese asthmatics, Pro Am Thorac Soc. 2008, 3: A472. |
|
Mak
J.C.W., Ho S.P., Yu W.C.,
Choo K.L., |
|
Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
|
Researcher
: Ho WL |
|
List of Research Outputs |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Researcher
: Ho WM |
|
List of Research Outputs |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Researcher
: Hoo RLC |
|
Project Title: |
Role of adiponectin in mediating the therapeutic actions of the anti-diabetic drug thiazolidinediones |
|
Investigator(s): |
Hoo RLC, Xu A, Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2005 |
|
Abstract: |
|
Thiazolidinediones (TZDs), such as rosiglitazone and pioglitazone, are peroxisome-proliferator-activated receptor gamma (PPAR-gamma) agonists widely used in the treatment of type 2 diabetes. The cellular mechanism of action of TZDs involves binding to the PPAR-gamma, thus altering the expression of PPAR-gamma responsive gene in fat cells, as well as other cell types such as endothelial cells, macrophage, monocytes, vascular smooth cells (1,2). We and others have shown that they can reduce insulin resistance, hyperglycaemia, and endothelial dysfunction, an early change in atherosclerosis (3-6). However, the mechanism underlying the ability of PPAR-gamma agonists to improve in vivo hyperglycemia and insulin resistance is not well understood. Adipose tissue is now recognized as an important endocrine organ as it can secrete a variety of biologically active peptides such as adiponectin, plasminogen activated inhibitor I (PAI-1), resistin, leptin, TNF-alpha and IL-6. These adipokines are suggested to be critically involved in regulating systemic energy metabolism, insulin sensitivity, cardiovascular tone and immune response (6,7). Our group has been actively studying the regulation and function of adiponectin in recent years. We have shown that treatment with adiponectin can result in direct beneficial effects on insulin resistance, hyperglycaemia, dyslipidaemia and atherogenesis. Many pharmacological studies showed that TZDs, including rosiglitazone, can elevate the mRNA expression and plasma levels of adiponectin in animals and in patients with type 2 diabetes (10,11). However, whether adiponectin mediates the TZD's metabolic effects in T2DM and its related metabolic syndrome remains uncertain. Therefore, in the present study, we seek to investigate the mechanism of metabolic action of a potent TZD, rosiglitazone, in the presence or absence of adiponectin, by using a genetically modified mouse model that lacks both the adiponectin gene and leptin receptor. Major Objectives: The major aim of this study is to elucidate the involvement of adiponectin in the therapeutic function of the potent TZD, rosigltiazone, in the treatment of T2DM. The specific objectives are: 1. To knockout the adiponectin gene from the db/db diabetic mouse model. 2. To use the double knockout mice generated in Objective 1 to investigate whether adiponectin is required for the anti-diabetic action of rosiglitazone. |
|
List of Research Outputs |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis , 13 th Medical Research Conference, The University of Hong Kong. 2008. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis, 13th Medical Research Conference, HKU, 19 Jan 2008, Hong Kong. 2008. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Hoo R.L.C., Yeung C.Y., Lam K.S.L. and Xu A., Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid binding protein, In: Future drugs Ltd, Expert Rev. Endocrinol. Metab.. 2008, 3: 29-41. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Zhou
M., Wang Y., Lam K.S.L., Tam P.K.H., Hoo R.L.C., Liu J. and Xu A., Increased Vulnerability to Liver
Injury is Associated with Decreased Mitochondrial Activities in Adiponectin
Knockout Mice: Potential Roles of UCP |
|
Researcher
: Hu HC |
|
Project Title: |
A study to validate a symptom severity questionnaire for patents with functional dyspepsia |
|
Investigator(s): |
Hu HC, Lam CLK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Health Services Research Fund - Full Grants |
|
Start Date: |
10/1998 |
|
Abstract: |
|
To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia. |
|
Researcher
: Huang J |
|
Project Title: |
Hepatitis B or Hepatitis C viral infection and genotypes - which subgroup is more prone to the development of hepatocellular carcinoma? A systematic review |
|
Investigator(s): |
Huang J, Wong BCY, Lai CL, Yuen RMF |
|
Department: |
Clinical Trials Ctr |
|
Source(s) of Funding: |
Health and Health Services Research Fund - Full Grants |
|
Start Date: |
01/2004 |
|
Abstract: |
|
To identify which subgroups of population infected with HBV/HCV are at higher risk for developing hepatocellular carcinoma (HCC). |
|
Researcher
: Huang Q |
|
Project Title: |
Powerful and robust association studies of six positional and functional candidate genes with bone mass in Southern Chinese |
|
Investigator(s): |
Huang Q, Kung AWC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Background Osteoporosis is a skeletal
disease characterized by low bone mineral density (BMD) and microarchitectural
deterioration of bone tissue, with a consequent increase in bone fragility
and susceptibility to fracture. The most common clinical outcomes of
osteoporosis are fracture of the spine, hip and wrist. Of these, hip
fractures are the most severe, leading to a 12-20% reduction of expected
survival. The direct cost for hip fractures was around $13.8 billion in the |
|
Project Title: |
Systematic evaluation and screen of the regions previously linked to osteoporosis in Southern Chinese |
|
Investigator(s): |
Huang Q, Kung AWC, Sham PC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2006 |
|
Abstract: |
|
To determine whether the genomic regions previously identified in genome scans contribute to osteoporosis/BMD in Southern Chinese by performing genetic linkage analyses; to investigate whether genetic variability in candidate genes in the region of linkage is associated with BMD variation. |
|
Project Title: |
To evaluate the contribution of six monogenic bone disease genes to common osteoporosis in Chinese |
|
Investigator(s): |
Huang Q, Kung AWC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Complex diseases such as osteoporosis
result from the combined effects of variation in a number of genes as well as
environmental factors (1-2). Identification of susceptibility gene(s)
underlying complex diseases remains a difficult challenge in the genome era.
Previous efforts to identify osteoporosis genes have focused on three
approaches: genome-wide scans, candidate gene study, and animal models (2).
Although genome-wide linkage scans in human have identified a few significant
or suggestive linkage regions for bone mineral density (BMD), the responsible
genes in these linkage regions have not been identified. Previous association
studies of functional candidate genes based on one or a few markers have
generated inconsistent results. Alox15, the first gene that regulates BMD and
is identified by positional cloning in mice has not been consistently
confirmed in humans (1). Limited success in identifying osteoporosis
susceptibility gene(s) might necessitate the development of new gene
identification strategies. Accumulating evidence shows that genes that cause
monogenic diseases also contribute to similar complex disease in the general
population, and identification and characterization of monogenic disease
genes can provides new clues for understanding complex diseases (3-4). A
well-known example in the study of bone is the identification of LPR5 gene
mutations. Inactivating mutations of the LRP5 gene are the cause of
osteoporosis pseudoglioma syndrome (5), whereas activating mutations in the
same gene causes autosomal dominant inheritance of high bone mass (6-7).
Follow-up studies have shown that LRP5 polymorphisms may also contribute to
normal variation in BMD in the general population (1). LPR5 is a co-receptor
for Wnt. Of the pathways activated by Wnts, it is signaling through the
canonical (i.e., Wnt/beta-catenin) pathway that increases bone mass through a
number of mechanisms including renewal of stem cells, stimulation of
preosteoblast replication, induction of osteoblastogenesis, and inhibition of
osteoblast and osteocyte apoptosis (8). Identification of the LPR5 gene has
provided insight into the regulation of bone mass by Wnt signaling, paving
the way towards understanding of the molecular mechanism behind common
osteoporosis. The discovery of the LRP5 gene as a genetic element in BMD
regulation in monogenic bone disease as well as BMD variation in the normal
population indicates that 'Mendelian' strategy may be a powerful approach for
searching for susceptibility genes that affect complex diseases such as osteoporosis.
Osteoporosis is a disease characterized by low BMD, deterioration in bone
microarchitecture and increased fracture risk. Osteoporosis and fragility
fractures are features of several rare monogenic bone diseases. Spectacular
progress has been made in the past few years in identifying genes for rare
monogenic bone diseases (1): osteogenesis imperfecta, COLIA1;
osteoporosis-pseudoglioma syndrome, LRP5; osteopetrosis, TCIRGI;
Camurati-Engelmann disease, TGFß-1; sclerosteosis/van Buchem disease, SOST;
severe infantile osteopetrosis, CLCN7; osteopetrosis with renal tubular
acidosis, CA2; pyknodysostosis, CTSK; McCune-Albright syndrome, GNAS1;
diastrophic dysplasia, DTDST; multiple epiphyseal dysplasia, COMP; and
cleidocranial dysplasia, CBFA1. If severe mutations lead to rare monogenic
disease, more subtle mutations might play a role in determining
susceptibility to common complex diseases. Preliminary studies in Caucasians
indicate that some genes that are mutated in rare bone diseases also contribute
to the regulation of BMD in the normal population (1). Therefore, mutant
genes that give rise to monogenic bone diseases provide a unique opportunity
to understand the allelic variability for susceptibility to osteoporosis. The
purpose of this project is to determine whether the allelic variation in six
monogenic bone disease genes (CLCN7, TCIRGI, SOST, CA2, CSTK, and DTDST)
contributes to osteoporosis / BMD variation in the normal Chinese population
by performing gene-wide and tag SNP-based association analyses. Preliminary
data from this study will provide strong support in using 'Mendelian'
strategy to identify the genes/variants involved in susceptibility to
osteoporosis in Chinese in future RGC application. References 1. Huang QY,
Kung AWC. Genetics of osteoporosis. Mol Genet Metab, 2006, 88: 295-306 2.
Huang QY, Recker RR, Deng HW. Searching for the osteoporosis gene(s) in the
post-genome era: progress and challenge. Osteoporos Int, 2003, 14(9):701-715
3. Peltonen L, Perola M, Naukkarinen J, Palotie A. Lessons from studying
monogenic disease for common disease. Hum Mol Genet, 2006,15: R67-74 4.
Antonarakis SE, Beckmann JS. Mendelian disorders deserve more attention. Nat
Rev Genet, 2006, 7(4):277-82 5. Gong Y, Slee RB, Fukai N, et al.
Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related
protein 5 (LRP5) affects bone accrual and eye development. Cell, 2001, 107:
513-523 6. Little RD, Carulli JP, Del Mastro RG, et al. A mutation in the LDL
receptor-related protein 5 gene results in the autosomal dominant
high-bone-mass trait. Am J Hum Genet, 2002, 70: 11-19 7. Boyden LM, Mao J,
Belsky J, et al. High bone density due to a mutation in LDL-receptor-related
protein 5. |
|
List of Research Outputs |
|
Cheung C.L., Huang Q., Chan V.N.Y. and Kung A.W.C., Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women., Hum Hered. 2007, 65(4): 232-239. |
|
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease gene identification strategy, 57th Annual Meeting of The American Society of Human Genetics. 2007, 80(suppl): T2119. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease-gene identification strategy, J Hum Genet. 2008, 53: 644-655. |
|
Huang Q. and Kung A.W.C., The association of common polymorphisms in the QPCT gene with bone mineral density in Chinese population, J Hum Genet. 2007, 52(9): 757-762. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Prediction of candidate genes for osteoporosis by a combination of computational disease gene prioritization methods, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Prediction of osteoporosis susceptibility genes by computational disease gene identification strategy., 3rd International Symposium on Healthy Aging, 1-2 March 2008, Hong Kong. 2008. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Quantity trait loci
influencing bone mineral density variation were mapped to 7p14 and 7p |
|
Researcher
: Hui CK |
|
Project Title: |
Significance of occult hepatitis B infection in patients undergoing autologous HSCT |
|
Investigator(s): |
Hui CK, Liang RHS, Lau G, Lie AKW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
10/2006 |
|
Abstract: |
|
(1) The occurrence of de novo HBV or occult HBV infection with or without clinical hepatitis after HSCT in HBsAg negative patients pre-HSCT; (2) the risk of transmitting de novo or occult HBV from occult HBV infected blood products to HBsAg negative immunocompromised patients. |
|
List of Research Outputs |
|
Au W.Y., Liu C.L., Tam S., Fong B.M., Shek T.W.H., Hui C.K. and Kwong Y.L., Oral arsenic trioxide therapy for acute promyelocytic leukemia before and after liver transplantation for hepatitis B virus-related liver failure, Annals of Hematology. 2007, 86(10): 771-2. |
|
Chen Y., Lin M.C., Yao H., Wang H., Zhang A.Q., Yu J., Hui C.K., Lau G., He M.L., Sung J. and Kung H.F., Lentivirus-mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-regulation of Stathmin (Erratum in: Hepatology. 2007 Oct;46(4):1314), Hepatology. 2007, 46(1): 200-208. |
|
Hui C.K., Leung N., Shek T.W.H., Zhang H., Luk J.M.C., Poon R.T.P., Lo C.M., Fan S.T. and Lau G., Changes in liver histology as a surrogate endpoint of antiviral therapy for chronic HBV can predict progression to liver complications, Journal of Clinical Gastroenterology. 2008, 42(5): 533-538. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Lau G., Zhang H., Li J., Hui C.K., Yeung Y.H., Wang Y.D. and Yie D.W., IL-17 stimulating HBV leaving from PBMC may help HBV clearance in serum of chronic HBV patients under pegylated interferon., In: Zhang HY, Li J, Hui CK, Yeung YH, Wang YD, Yie DW, Lau GK. , J Hepatol 2008. 48: S219. |
|
Luk J.M.C., Wang X., Liu P., Wong K.F., Chan K.L., Tong Y., Hui C.K., Lau G. and Fan S.T., Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation, Liver International. 2007, 27(7): 879-890. |
|
Researcher
: Hui WM |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Lam T.J., Wong B.C.Y., Mulder C.J., Pena A.S. and Hui W.M., Increasing Prevalence Of Advanced Colonic Polyps In Young Patients Undergoing Colonoscopy In A Referral Academic Hospital In Hong Kong., World J Gastroenterol . 2007, 13(28): 3873-7. |
|
Researcher
: Hung IFN |
|
List of Research Outputs |
|
Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
|
Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
|
Hung I.F.N., Poon R.T.P., Lai C.L., Fung J.Y.Y., Fan S.T. and Yuen R.M.F., Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection., American Journal of Gastroenterology. 2008, 103(7): 1663-1673. |
|
Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
|
Researcher
: Ip MSM |
|
Project Title: |
The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea |
|
Investigator(s): |
Ip MSM |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
02/1997 |
|
Abstract: |
|
To assess the efficacy, side effects and patient acceptance of an oral appliance in the treatment of obstructive sleep apnoea; to define the clinical, anthropometric, polysomnographic and cephalometric characteristics that determine treatment response. |
|
Project Title: |
The effect of oral appliance (OA) in treatment of obstructive sleep apnoea |
|
Investigator(s): |
Ip MSM, Peh WCG, Cooke MS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
06/1997 |
|
Abstract: |
|
To study the efficacy of OA in teatment of mild/moderate OSA; to study the safety profile of OA. |
|
Project Title: |
Role of adiponectin in obstructive sleep apnoea |
|
Investigator(s): |
Ip MSM, Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To investigate serum adiponectin levels in OSA patients with a spectrum of body mass index (BMI) and sleep disordered breathing (no OSA to severe OSA) and define correlative parameters; to investigate for any difference in adiponectin levels in patients with OSA and BMI-matched subjects with no OSA (3) the impact of nasal Continuous Positive Airway pressure (nCPAP) treatment on adiponectin secretion in subjects with OSA. |
|
Project Title: |
Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese |
|
Investigator(s): |
Ip MSM, Lam KSL, Song Y, Sham PC, Lam CL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Abstract: |
|
The main objectives of this project are: 1) To study the presence and role of genetic polymorphism of selected candidate genes relating to the obesity phenotypes in the OSA patients in Hong Kong 2) As an initiating project, to provide pilot data on the role of genetic changes in selected candidate genes in Chinese OSA patients, and to prepare for future in-depth studies in family cohorts |
|
Project Title: |
Endothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products |
|
Investigator(s): |
Ip MSM, Tse HF, Tan KCB, Ooi CGC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To explore the relationship between insulin resistance and the formation of advanced glycation end products (AGE) in obstructive sleep apnea (OSA); to evaluate the role of AGE in vascular endothelial damage in OSA; to investigate the relationship between AGE and atherosclerosis in OSA. |
|
List of Research Outputs |
|
Chan C.H., Shum D.K.Y., Tipoe G.L., Mak J.C.W., Leung T.M. and Ip M.S.M., Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis, Respiratory Medicine. 2008, 102: 287-298. |
|
Chan
M.M.W. and Ip M.S.M.,
Asthma, In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory
Medicine, 3rd Edition, 2007. |
|
Cheung T.K., Lam B., Ip M.S.M., Kung R., Ng C.Y.C. and Wong B.C.Y., Gastro-esophageal reflux disease negatively impacted on asthma control, quality of life and psychological status in Chinese asthma patients, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Fong D.Y.T., Lau A.C. and Ip M.S.M., Substantial differences in percentage of predicted FEV, Chest. 2008, 133: 1289. |
|
Ho J.C.M., Lam B., Ip M.S.M. and Lam W.K., Clinical Respiratory Medicine, 3rd edition, Hong Kong, 2007. |
|
Ip
M.S.M., Chairperson, Symposium, Annual
Scientific Meeting, |
|
Ip
M.S.M., Chairperson, Symposium, Annual
Scientific Meeting, |
|
Ip
M.S.M., Circulating nitric oxide is
supporessed in OSA and is reversed by nCPAP, International Symposium on
the Chinese Sleep Disorder, |
|
Ip
M.S.M., Development of sleep medicine in Hong
Kong, 2008 |
|
Ip
M.S.M., Insulin resistance and the metabolic
syndrome in OSAS, 5th World Sleep Congress of the WFSRSMS, |
|
Ip M.S.M., OSA and Atherosclerosis - Ready For Prime Time, XI "Hot topics" in Sleep Apnea, Lleida, Spain. 2008. |
|
Ip
M.S.M., Obstructive sleep apnea and the
metabolic consequences, American Thoracic Society International
Conference, |
|
Ip
M.S.M., Obstructive sleep apnoea and aging
diseases, 3rd International Symposium on Healthy Aging: "Improving
the Health of an Aging Population", LKS Faculty of Medicine, The |
|
Ip
M.S.M., Open Forum on Euthanasia at |
|
Ip
M.S.M., Oxidative stress and systemic
inflammation, XI "Hot topics" in Sleep Apnea, Lleida, |
|
Ip M.S.M. and Mokhlesi B., Sleep and glucose intolerance/diabetes mellitus, Sleep Medicine Clinic. 2007, 2: 19-29. |
|
Ip
M.S.M., Sleep apnea, Radio Television |
|
Ip M.S.M., Ten years On: Where are we now, Frontiers in Medical Education, LKS Faculty of Medicine, HKU. 2007. |
|
Ip
M.S.M., Update on obstructive sleep apnoea
and the metabolic syndrome, 2008 |
|
Lam
B., Fung S.L., Lam D.C.L., Lui M.M.S., Yew W.W., Ip M.S.M. and Lam W.K., Initial experience of using
flexi-rigid pleuroscopy for the diagnosis of exudative pleural effusion in |
|
Lam B., Sam K., Lai A.Y.K., Lam J.C.M., Lam D.C.L. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Lam D.C.L., Lam B. and Ip M.S.M., Chronic obstructive
pulmonary disease. In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Lam D.C.L. and Ip M.S.M., Musculoskeletal
restrictive pulmonary disease. In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Lam J.C.M. and Ip M.S.M., An update on obstructive sleep apnea and the metabolic syndrome, Current Opinion in Pulmonary Medicine. 2007, 13: 484-489. |
|
Lam J.C.M. and Ip M.S.M., Bronchiectasis. In: Eds.
Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory Medicine, 3rd Edition,
2007. |
|
Lam J.C.M., Lam B. and Ip M.S.M., Sleep apnea hypopnea
syndrome. In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory
Medicine, 3rd Edition, 2007. |
|
Lam
W.K. and Ip M.S.M., Clinical
curriculum, In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory
Medicine, 3rd Edition, 2007 . |
|
Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L.,
Tang K.S., Yam L.Y.C. and Chan M.M.W., Variability of the
prevalence of undiagnosed airflow obstruction in smokers using different
diagnostic criteria, 12th Congress of the Asian Pacific Society of
Respirology / 2nd Joint Congress of the Asian Pacific Society of
Respirology/American College of Chest Physicians, Queensland, Australia.
Respirology. 2007, 12 (supp 4): A115 ( |
|
Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L., Tang K.S., Yam L.Y.C. and Chan M.M.W., Variability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteria, Chest. 2008, 133: 42-48. |
|
Leung O.Y.V., Chan C.H., Ip M.S.M. and Shum D.K.Y., Development of heparin and heparan sulfate from recombinant syndecan-1 as a potential therapeutic for bronchiectasis, Third International Symposium on Healthy Aging: “Improving the Health of an Aging Population” March 1-2, 2008. |
|
Leung S.K., Yew W.W., Wong P.C., Fong D.Y.T., Lau A.C. and Ip M.S.M., Lung function testing prediction equations: do they fit all?, Chest. 2008, 133: 1288-1289. |
|
Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481. |
|
Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
|
Tasali E. and Ip M.S.M., Obstructive sleep apnea and metabolic syndrome: Alterations in glucose metabolism and inflammation, Proceedings of the American Thoracic Society. 2008, 5: 207-217. |
|
Wang J. and Ip M.S.M., Approach to respiratory
symptoms: IV: chest pain. In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Wong M.K., Wong M.P., Lam D.C., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2008. |
|
Researcher
: Jim MH |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Researcher
: Jin O |
|
List of Research Outputs |
|
Sun L.Y., Zhou K.X., Feng X.B., Zhang
H.Y., Ding X.Q., Jin O., Lu L., Lau W.C.S., Hou Y.Y. and Fan L.M.,
Abnormal Surface Markers Expression on Bone Marrow CD34+ cells and
Correlation with Disease Activity in Patients with Systemic Lupus
Erythematosus, Clinical Rheumatology. |
|
Researcher
: Jin Y |
|
Project Title: |
Cytogenetic and molecular genetic characterization of esophageal carcinomas |
|
Investigator(s): |
Jin Y, Kwong YL, Tsao GSW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
10/2002 |
|
Abstract: |
|
To identify, by cytogenetic, fluorescence in situ hybridization (FISH), and molecular genetic approaches, the genetic changes that are important in the malignant transformation of esophageal epithelium; to investigate genetic differences and similarity between immortalized, preneoplastic esophageal epithelial cells and aquamous cell carcinoma (SCC) of the esophagus. |
|
Researcher
: Kung AWC |
|
Project Title: |
Evaluation of maternal and fetal modulators in the development of postpartum autoimmune thyroiditis in a murine model of experimental autoimmune thyroiditis induced by thyroid peroxidase |
|
Investigator(s): |
Kung AWC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To determine the incidence of pregnancy outcome in a murine model of AITD induced by immunizing C57B/6(H2[b]) mice with homologous mouse TPO, and to determine the pathogenicity of anti-TPO Ab against placental and fetal antigen; to determine the severity of postpartum thyroiditis in allogeneic C57B/6(H2[b]) x CBA/J(H2[d]) versus synergeneic C57B/6(H2[b]) x C57B/6(H2[b]) and CBA/J(H2[d]) x CBA/J(H2[d]) animals; to determine the cytokine profile in the above animals during pregnancy and postpartum period |
|
Project Title: |
To discover new genes in chromosome 14q11-32 for the determination of osteoporosis and boen mineral density |
|
Investigator(s): |
Kung AWC, Luk KDK, Chan VNY, Sham PC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
08/2005 |
|
Abstract: |
|
Phase I: to determine the linkage and association of markers in the chromosomal region 14q11-32 with bone mineral density (BMD) at the spine and hip using two approaches: (1) linkage analysis by multipoint allele-sharing methods in 250 extended southern Chinese families. (2) case-control association study using haploytpe-tagging SNPs in southern Chinese subjects. Phase II: to identify the candidate gene(s) by differential gene expression method. |
|
Project Title: |
Analysis of Na+/myo-inositol cotransporter (SMIT1) as a regulator of bone growth and bone mass |
|
Investigator(s): |
Kung AWC, Chung SK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
OBJECTIVESa. To characterize the bone
abnormality of SMIT1-/-knockout mice.b. To identify the embryonic stage that
is critical for myo-Inositol (Ins) and SMIT1 involvement in bone development.
c. To determine the cellular pathway of SMIT |
|
List of Research Outputs |
|
Adachi J.D., Chesnut C.H., Brown J.P., Christiansen C., Russo L.A., Fernandes C.E., Menegoci J.C., Kung A.W.C., Chines A.A., Bessac L. and Chakrabarti D., Safety and Tolerability of Bazedoxifene in Postmenopausal Women with Osteoporosis: Results from a 3-Year, Randomized, Placebo- and Active-Controlled Clinical Trial, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Chan B.Y.Y., Lau K.S., Jiang B., Kennelly E.J., Kronenberg F. and Kung A.W.C., Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells, BONE. 2008. |
|
Cheung C.L., Chan V.N.Y. and Kung A.W.C., A differential association of ALOX15 polymorphisms with bone mineral density in pre- and postmenopausal women., Human Heredity. 2008, 65(1): 1-8. |
|
Cheung C.L., Huang Q., Chan V.N.Y. and Kung A.W.C., Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women., Hum Hered. 2007, 65(4): 232-239. |
|
Cheung C.L., Tang L.F., Sham P.C., McClug P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide Haplotype Association Mapping (HAM) in Mice Leads to an Identification of a Genetic Variant in CER1 Associated with Bone Mineral Density in Premenopausal Women, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. |
|
Cheung C.L., Tang P.L.F., Sham P.C., McClurg P., Chan S.Y., Smith D.K., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping (HAM) in mice leads to an identification of a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Cheung C.L., Sham P.C., Chan V.N.Y., Paterson A.D., Luk K.D.K. and Kung A.W.C., Identification of LTBP2 on chromosome 14q as a novel candidate gene for BMD variation and fracture risk association, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Chu L.W., Tam S., Kung A.W.C., Lo S., Fan S., Wong L.C., Morley J.E. and Lam K.S.L., Serum total and bioavailable testosterone levels, central obestiy and muscle strength changes with aging in healthy Chinese men, Journal of American Geriatrics Society. 2008, 56(7): 1286-1291. |
|
Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
|
Fan
N.Y., Cheung W.M.W. and Kung A.W.C., Protein Kinase D Is an
Essential Mediator During Osteoblast Differentiation, 29th Annual Meeting
of the American Society for Bone and Mineral Research, |
|
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease gene identification strategy, 57th Annual Meeting of The American Society of Human Genetics. 2007, 80(suppl): T2119. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease-gene identification strategy, J Hum Genet. 2008, 53: 644-655. |
|
Huang Q. and Kung A.W.C., The association of common polymorphisms in the QPCT gene with bone mineral density in Chinese population, J Hum Genet. 2007, 52(9): 757-762. |
|
Kung
A.W.C., Asian therapeutic recommendation, Strong
Bone Asia 2007, |
|
Kung
A.W.C., Yates
S.J. and Wong V.K.H., Changing
epidemiology of osteoporotic hip fracture rates in |
|
Kung
A.W.C., |
|
Kung A.W.C., Chinese Journal of Osteoporosis and Bone Mineral Research. 2008. |
|
Kung A.W.C., Chinese Medical Journal. 2007. |
|
Kung
A.W.C., Choice of medication for osteoporosis
in Asia, Strong Bone Asia 2007, |
|
Kung
A.W.C., Clinical evaluation, IOF
Osteoporosis Diagnosis Course with Densitometry Certification, 2-3 Aug 2007, |
|
Kung
A.W.C., Clinical management: Prevention., IOF
Osteoporosis Diagnosis Course with Densitometry Certification, 2-3 Aug 2007, |
|
Kung
A.W.C., Diagnostic use of densitometry II:
Interpretation and pitfalls, IOF Osteoporosis Diagnosis Course with
Densitometry Certification, 2-3 Aug 2007, |
|
Kung A.W.C. and Lee K.K., Effect of anti-resorptive agents on fracture rates in subjects selected for therapy on the basis of clinical risk factors or low bone mineral density, American Society for Bone and Mineral Research 29th Annual Meeting, Hawaii, USA. 2007. |
|
Kung A.W.C. and Lee K.K., Effect of bisphosphonates on bone mineral density in subjects with normocalcaemic primary hyperparathyroidism, 29th Annual Meeting of the American Society for Bone and Mineral Research, Hawaii, USA. 2007. |
|
Kung A.W.C., Genetics and osteoporosis, CMED 6212 Public Health Genetics, School of Public Health, HKU, Hong Kong. 2007. |
|
Kung
A.W.C., Genetics of osteoporosis, The 3rd
International Conference on Osteoporosis and Bone Research, |
|
Kung A.W.C., Incidence & Impact of Ostroporosis in Hong Kong, Hong Kong Baptist Hospital CME Programme, Hong Kong. 2007. |
|
Kung
A.W.C., Iodine nutrition of pregnant and
lactating women in |
|
Kung A.W.C., Journal of Clinical Endocrinology & Metabolism. 2007. |
|
Kung
A.W.C., MIMS Endocrinology |
|
Kung
A.W.C., Male osteoporosis, AFES 2007, 14th
Congress of the ASEAN Federation of Endocrine Societies, |
|
Kung
A.W.C., Monitoring skeletal changes, IOF
Osteoporosis Diagnosis Course with Densitometry Certification, 2-3 Aug 2007, |
|
Kung
A.W.C., Osteoporosis in Asia Pacific, Asia
Pacific Bone VIP User Meeting Provisional Programme, |
|
Kung
A.W.C., Osteoporosis: The scope of the
problem, IOF Osteoporosis Diagnosis Course with Densitometry
Certification, 2-3 Aug 2007, |
|
Kung A.W.C., Osteroporosis International. 2007. |
|
Kung
A.W.C., Risk assessment, IOF Osteoporosis
Diagnosis Course with Densitometry Certification, 2-3 Aug 2007, |
|
Kung A.W.C., Lee K.K., Ho A.Y.Y., Tang G.W.K. and Luk K.D.K., Ten-Year Risk of Osteoporotic Fractures in Postmenopausal Chinese Women According to Clinical Risk Factors and BMD T Scores: A Prospective Study, Journal of Bone and Mineral Research. 2007, 22: 1080-7. |
|
Kung
A.W.C., Unmet need in osteoporosis, Aclasta
Asia Pacific Go-to-launch Meeting, |
|
Kung
A.W.C., Updates on the diagnosis and
management of osteoporosis, 2007 |
|
Lai M.H., Cheung C.L., Luk K.D.K. and Kung A.W.C., Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women, Osteoporosis International. 2007, 19: 571-9. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Prediction of candidate genes for osteoporosis by a combination of computational disease gene prioritization methods, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Prediction of osteoporosis susceptibility genes by computational disease gene identification strategy., 3rd International Symposium on Healthy Aging, 1-2 March 2008, Hong Kong. 2008. |
|
Li G.H.Y., Kung A.W.C. and Huang Q., Quantity trait loci
influencing bone mineral density variation were mapped to 7p14 and 7p |
|
Lim S.K., Kung A.W.C., Sompongse S., Soontrapa S. and Tsai K.S., Vitamin D inadequacy in postmenopausal women in eastern Asia, Current Medical Research and Opinion. 2008, 24: 99-106. |
|
Siu D.C.W., Zhang X., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., Recurrence of Atrial Fibrillation in hyperthyroidism related atrial fibrillation: A matched case-control study., Heart Rhythm Society Scientific Meeting 2008. |
|
Tsang S.W.Y., Kung A.W.C., Kanis J.A., Johansson H. and Oden A., Application of WHO fracture prediction algorithm to estimate the 10-year osteoporotic fracture probability in Hong Kong southern Chinese, 9th Regional Osteoporosis Conference, Osteoporosis Society of Hong Kong, Hong Kong, May 17-18. 2008. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese population., 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Annul Scientific Meeting, Hong Kong. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Multifactor Dimensionality Reduction Reveals Antagonistic Epistasis Between ESR1 and ESR2 with BMD Variation in Southern Chinese Women, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Researcher
: Kung MHW |
|
List of Research Outputs |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Researcher
: Kwok HH |
|
List of Research Outputs |
|
Chan K.H., Ramsden D.B., Chu A.C.Y., Kwok H.H. and Ho S.L., NMO-IgG in idiopathic inflammatory demyelinating disorders in Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Researcher
: Kwok HH |
|
List of Research Outputs |
|
Chan K.H., Ramsden D.B., Chu A.C.Y., Kwok H.H. and Ho S.L., NMO-IgG in idiopathic inflammatory demyelinating disorders in Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
|
Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Ho W.L., Garner C.E., Ho W.M., Leung K.C., Chu A.C.Y., Kwok H.H., Kung M.H.W., Burka L.T., Ramsden D.B. and Ho S.L., Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk., Current Drug Metabolism. 2008, 9(4): 304-309. |
|
Researcher
: Kwong YL |
|
Project Title: |
Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies |
|
Investigator(s): |
Kwong YL, Liang RHS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
07/1997 |
|
Abstract: |
|
To provide purine analogues for the treatment of patients with chronic lymphoid malignancies who cannot otherwise afford the drugs. |
|
Project Title: |
Molecular
mechanisms and consequences of downregulation of p |
|
Investigator(s): |
Kwong YL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To define if p73 acts as a tumor
suppressor gene in natural killer (NK) cell lymphomas; to define the biologic
significance of re-expression of p |
|
Project Title: |
Molecular basis of arsenic resistance in tumours |
|
Investigator(s): |
Kwong YL, Tse EWC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To define the molecular basis of arsenic resistance in tumour cells. |
|
Project Title: |
Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation |
|
Investigator(s): |
Kwong YL, Liang RHS, Lie AKW, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To establish provisions of (a) free molecular / cytogenetic tests for monitoring of BMT patients, (b) free molecular / cytogenetic tests for BMT patients who have relapsed, so that their treatment can be guided and optimized, (c) free molecular / cytogenetic tests for referral patients from other hospitals. |
|
List of Research Outputs |
|
Au W.Y. and Kwong Y.L., Arsenic trioxide: safety issues and their management, Acta Pharmacologica Sinica. 2008, 29(3): 296-304. |
|
Au W.Y., Tam S. and Kwong Y.L., Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment , Leukemia Research. 2007, 32(2): 357-358. |
|
Au W.Y., Pang A.W.K., Lam K.Y., Song Y., Lam W.M., So J.C.C. and Kwong Y.L., G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors, Bone Marrow Transplantation. 2007, 40(7): 677-681. |
|
Au W.Y., Leung A.Y.H., Tse E.W.C., Cheung W.W., Shek T.W.H. and Kwong Y.L., High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients, Leukemia Research. 2007, 32(4): 547-551. |
|
Au W.Y., Liu C.L., Tam S., Fong B.M., Shek T.W.H., Hui C.K. and Kwong Y.L., Oral arsenic trioxide therapy for acute promyelocytic leukemia before and after liver transplantation for hepatitis B virus-related liver failure, Annals of Hematology. 2007, 86(10): 771-2. |
|
Au W.Y., Tam S., Fong B.M., Ho K.L., Tam P.C. and Kwong Y.L., Prolonged oral arsenic trioxide therapy and neprholithiasis, Leukemia and Lymphoma . 2007, 48(11): 2233-2234. |
|
Au W.Y., Tam S., Fong B.M., Wan T.S.K., Yip S.F. and Kwong Y.L., Second hematological malignancies during arsenic trioxide therapy of B-cell lymphomas , Leukemia Research. EPub, 2008. |
|
Chan K.K., Shen L., Guo T., Wong M.L.Y., Wong K.Y., Au W.Y., Lu L., Kwong Y.L., Liang R.H.S. and Srivastava G., IL2 induced NF-kB activation in nasal NK/T-cell lymphoma is mediated through Akt and BCL10, Keystone Symposia on Molecular and Cellular Biology: Lymphocyte Activation and Signaling, February 3-8, 2008, Snowbird Resort, Snowbird, Utah. 2008. |
|
Chau M.C., Chow W.H., Wang E. and Kwong Y.L., Cardiac amyloidosis - experience in a tertiary cardiac referral centre, International journal of cardiology. 2008, 124(2): 264-6. |
|
Ho J.C.M., Lo R.L.K., Lam W.K. and Kwong Y.L., Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., AJRCCM 2008;177(10) Suppl. 2008, A463. |
|
Hui C.K., Cheung W.W., Leung K.W., Cheng V.C.C., Tang S.F., Li W.S., Lee N.P., Kwong Y.L., Au W.Y., Yuen K.Y., Lau G. and Liang R.H.S., Outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen, Hepatology. EPub, 2008. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Khong
P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18 fluorodeoxyglucose
positron emission tomography in mature T-cell and antural killer cell malignancies,
10th International Conference on Malignant Lymphoma, |
|
Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21. |
|
Le Coutre P., Ottmann O.G., Giles F., Kim D.W., Cortes J., Gattermann N., Apperley J.F., Larson R.A., Abruzzese E., O'Brien S.G., Kuliczkowski K., Hochhaus A., Mahon F.X., Saglio G., Gobbi M., Kwong Y.L., Baccarani M., Hughes T., Martinelli G., Radich J.P., Zheng M., Shou Y. and Kantarjian H., Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia, Blood. 2008, 111(4): 1834-1839. |
|
Lo R.L.K., Lam W.K., Kwong Y.L. and Ho J.C.M., Best poster - Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., 13th Medical Research Conference. 2008. |
|
Mak C.M., Kwong Y.L., Lam C.W., Chan S.C., Lo C.M., Fan S.T., Chang P.C.M., Lau Y.K., Lok Sun U. and Tam S., Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese, Amyloid. 2007, 14(4): 293-297. |
|
Man
C.W.Y., Rosa J., Yip Y.L., Cheung A., Kwong Y.L., Doxsey S.J. and Tsao G.S.W., Id1 overexpression induces
tetraploidization and multiple abnormal mitotic phenotypes by modulating
Aurora A , Molecular Biology Of The Cell. |
|
Pang R.W.C., Kwong Y.L. and Tse E.W.C., Pin1-HBx interaction: a step toward understanding the significance of hepatitis B virus genotypes in hepatocarcinogenesis., Gastroenterology. Elsevier, 2007, 133(2): 728-729. |
|
Shen L., Au W.Y., Guo T., Wong K.Y., Wong M.L.Y., Tsuchiyama J., Yuen P.W., Kwong Y.L., Liang R.H.S. and Srivastava G., Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: an in vitro and in vivo preclinical evaluation, Blood. 2007, 110(1): 469-70. |
|
Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
|
Tse H.F., Thambar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohon J., Bastian B., Chan J.K., Lo G., Ho C.L., Parker A., Hauser T.H. and Lau C.P., Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease, American Heart Journal. 2007, 154(5): 982.e1-982.e6. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Tse H.F., Thambsar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohn J., Thomas P., Bastian B., Chan J.K.F., Lo G., Ho C.L., Chan W.S., Kwong R.Y., Parker A., Hauser T., Chan J., Fong Y.T. and Lau C.P., Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases, European Heart Journal. 2007, 28: 2998-3005. |
|
Wong K.F., Tam S. and Kwong Y.L., Diagnosis of familial amyloidotic polyneuropathy by bone marrow biopsy, British Journal of Haematology. 2007, 139(4): 517. |
|
Yamaguchi M., Suzuki R., Kwong Y.L., Kim W.S., Hasegawa Y., Izutsu K., Suzumiya J., Okamura T., Nakamura S., Kawa K. and Oshimi K., Phase I study of dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia, Cancer Science. 2008, 99(5): 1016 - 1020. |
|
Researcher
: Lai AYK |
|
List of Research Outputs |
|
Lam B., Sam K., Lai A.Y.K., Lam J.C.M., Lam D.C.L. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Researcher
: Lai CL |
|
List of Research Outputs |
|
But D., Lai C.L. and Yuen R.M.F., Hepatitis virus related hepatocellular carcinoma., World J Gastroenterol. 2008, 14(11): 1652-1656. |
|
But D.Y., Lai C.L. and Yuen R.M.F., Natural history of hepatitis-related hepatocellular carcinoma, World Journal of Gastroenterology. 2008, 14: 1652-6. |
|
Chan H.L., Heathcote E.J., Marcellin P., Lai C.L., Cho M., Moon Y.M., Chao Y.C., Mayers R.P., Minuk G.Y., Jeffers L., Sievert W., Bzowej N., Harb G., Kaiser R., Qiao X.J., Brown N.A. and 018 Study Group , Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial, Annals of Internal Medicine. 2007, 147: 745-54. |
|
Chan P., Yuen R.M.F. and Lai C.L., Chemotherapy and radiotherapy for the treatment of hepatocellular carcinoma., In: In McCulloch P ed, Gastrointestinal Oncology: Evidence and analysis.. 2007, 309-316. |
|
Fung J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis, Liver International. 2008. |
|
Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
|
Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
|
Fung J.Y.Y., Yuen R.M.F., Yuen J.C.H., Wong D.K.H. and Lai C.L., Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study. , Aliment Pharmacol Ther. 2007, 26: 377-382. |
|
Fung
J.Y.Y., Lai C.L. and Yuen R.M.F., New paradigms for the
treatment of chronic hepatitis B, Journal
of Gastroenterology and Hepatology. 2008, 23( |
|
Fung
J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, Hepatology. 2007, 6(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., Fong
D.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management, American Journal of Gastroenterology. 2008, 103: 1421-1426. |
|
Fung
J.Y.Y., Lai C.L., But D., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, Hepatology.
2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., But D.Y.,
Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, The
58th Annual Meeting of the American Association of the Study of Liver
Diseases, Boston, USA. 2007, |
|
Fung
J.Y.Y., Lai C.L., Tanaka
Y., Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT
and HBeAG status after stopping lamivudine in patients with HBeAg
seroconversion, Hepatology. 2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., Tanaka
Y., Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT,
and HBeAg status after stopping lamivudine in patients with HBeAg
seroconversion, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment of Chronic Hepatitis C with Different Genotypes, In: Emilio Jirrilo, Hepatitis C Virus Disease. Springer, 2007. |
|
Fung K.T.T., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Etiologies of chronic liver diseases in Hong Kong, Eur J Gastroen Hepat. 2007, 19(8): 659-64. |
|
|
|
Hung I.F.N., Poon R.T.P., Lai C.L., Fung J.Y.Y., Fan S.T. and Yuen R.M.F., Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection., American Journal of Gastroenterology. 2008, 103(7): 1663-1673. |
|
Lai C.L., 96 weeks of Entecavir (ETV) re-treatment of HBeAg(-) ETV patients who previously discontinued treatment, 18th Conference of the Asian Pacific Association for the Study of the Liver (APASL) in Seoul, Korea. 2008. |
|
Lai C.L., A man with worsening jaundice and confusion, In: Mark Strachan, Surendra Sharma and John Hunter ed., Davidson’s Clinical Cases. Edinburgh, UK, Elsevier Ltd, 2008, Chap 64: pp 222-224. |
|
Lai
C.L., Advances in the CHB treatment strategy,
Hongkong-shenzhen communication conference on CHB management in |
|
Lai C.L., CHB natural history and treatment paradigm, Baraclude (Entecavir) Speaker Training Program ‘Evolving treatment paradigms in CHB’. 2008. |
|
Lai C.L., CHB treatment guidelines: do they advance or represent roadblocks to appropriate treatment of patients?, CME-accredited satellite symposium ‘Chronic HBV infection: Navigating the road to successful patient outcomes’ during the 58th Annual Meeting of the American Association for the Study of Liver Diseases at Boston, USA. 2007. |
|
Lai C.L., Chronic hepatitis B infection: (a) critical approach to treatment guidelines; (b) the telbivudine (GLOBE) trial, Round Table Discussion Meeting on ‘The latest approach for the management of chronic hepatitis B’ organized by the Infection Control Committee of Macau Government Hospital, Macau. 2007. |
|
Lai
C.L., Co-chairman, Postgraduate Course 2:
Overview of Hepatitis B and Poster Presentation & Exhibition I: Poster
Presentation 2: Hepatitis B (II) at the 18th Conference of the Asian Pacific
Association for the Study of the Liver (APASL) in |
|
Lai
C.L., Current and future strategies in
improving treatment outcomes In chronic hepatitis B, Inaugural Conference
of the Hepatology Society of |
|
Lai
C.L., Currently licensed agents and their
comparison, BMS sponsored satellite symposium in in the |
|
Lai C.L., Discovery and prospects for new HBV therapy, 18th Conference of the Asian Pacific Association for the Study of the Liver (APASL) in Seoul, Korea. 2008. |
|
Lai C.L., Emerging therapy for chronic hepatitis B, APASL Single Topic Conference on Innovative of CHB Management in Pattaya, Thailand. 2007. |
|
Lai
C.L., Emerging therapy for chronic hepatitis
B, International Symposium on Hepatology |
|
Lai C.L., Emerging therapy for chronic hepatitis B” at the Postgraduate Course 2: Overview of Hepatitis B, 18th Conference of the Asian Pacific Association for the Study of the Liver (APASL) in Seoul, Korea. 2008. |
|
Lai
C.L., Mapping the Future – Resistance Forum, Educational
Forum, Asia Pacific Resistance Advisory Board Meeting in |
|
Lai C.L., Member of the Editorial Advisory Board, Medical Tribune Hong Kong. 2007. |
|
Lai C.L., Member of the Editorial Board, Current Hepatitis B Reports. 2007. |
|
Lai C.L., Member of the Editorial Board, Hepatology International. 2007. |
|
Lai C.L., Member of the Editorial Board, Journal of Viral Hepatitis. 2007. |
|
Lai C.L., Optimal screening programme for HCC in endemic areas” at the session ‘Plenary I – Early diagnosis of prevalent cancers: screening amd imaging, Inaugural William and Elizabeth Davies Foundation Trust International Meeting jointly organized by the Royal College of Physicians and Surgeons of Glasgow and the Hong Kong College of Physicians in Hong Kong. 2008. |
|
Lai C.L., Review of telbivudine GLOBE trial (year 1 and year 2) and using baseline predictive results to optimize results in HBV pos & neg patients, Hong Kong Association for the Study of Liver Diseases symposium on ‘Bridges to new ways on HBV care’ . 2007. |
|
Lai C.L., Gane E., Liaw Y.F., Hsu C.W., Thongsawat S., Wang Y., Chen Y., Heathcote E.J., Rasenack J., Bzowej N., Naoumov N.V., Di Bisceglie A.M., Zeuzem S., Moon Y.M., Goodman Z., Chao G., Constance B.F., Brown N.A. and Globe Study Group , Telbivudine versus lamivudine in patients with chronic hepatitis , New England Journal of Medicine. 2007, 357: 2576-88. |
|
Lai C.L. and Yuen R.M.F., The natural history and treatment of CHB: critical evaluation of treatment criteria and endpoints, Ann Intern Med. 2007, 147(1): 58-61. |
|
Lai C.L. and Yuen R.M.F., The natural history of chronic hepatitis B., J Viral Hepatitis . 2007, 14 (Suppl 1): 6-10. |
|
Lai C.L., Treatment goals: can CHB be cured?, APASL Single Topic Conference on Innovative of CHB Management in Pattaya, Thailand. 2007. |
|
Lai C.L., Treatment paradigms in CHB, Singapore Physicians Symposium in Singapore. 2008. |
|
Lai
C.L., Two-Year Results from the GLOBE Trial:
Telbivudine (LdT) vs Lamivudine, Novartis (Sebivo) Launch Symposium of
Hepatology Society of |
|
Lai C.L., Update on chronic hepatitis B, 9th Joint Annual Scientific Meeting of The Hong Kong Society of Gastroenterology, The Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, Hong Kong Association for the Study of Liver Diseases and The Hong Kong Society of Gastrointestinal Motility. 2007. |
|
Lai
C.L., Update on hepatitis B, Medical Grand
Round of |
|
Lai
C.L., Fung
J.Y.Y. and Yuen R.M.F., Updates
in the Treatment of Chronic Hepatitis B., The |
|
Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Updates in the treatment of chronic hepatitis B, The Hong Kong Medical Diary. 2008, 13: 15-19. |
|
Lai C.L. and Yuen R.M.F., What is the best end point for hepatitis B treatment? , Ann Intern Med. 2008, 148: 560. |
|
Lai
C.L., 介紹各類型肝炎, 全港十八區巡迴健康展覧及講座
「與我何肝」之丙型肝炎 organized by the |
|
Lam
T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., Leung G.M. and McGhee S.M., Health-related Quality of
Life of Patients with Chronic Hepatitis B Infection. Oral, 2008 Asian
Chinese Quality of Life Conference. |
|
Lam
T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics
of the Chinese (Hong Kong) version of the chronic liver disease
questionnaire. Poster, 2007 International Society for Quality of Life
Research Annual meeting. |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics of the Chinese (Hong Kong) version of the chronic liver disease questionnaire, Quality of Life Research. 2007, A-48, Abstract #1472. |
|
Libbrecht E., Doutreloigne J., Van de Velde H., Yuen R.M.F. and Lai C.L., Evolution of Primary and Compensatory Lamivudine-Resistance Mutations during Long-term Lamivudine Treatment in Chronic HBV-Infected Patients Assessed by a Line Probe Assay., J Clin Microbiol. 2007, 45(12): 3935-41. |
|
Mak C.M., Lam C.W., Tam S., Lai C.L., Chan L.Y., Fan S.T., Lau Y.L., Lai J.Y., Yuen P., Hui J., Fu C.C., Wong K.S., Mak W.L., Tze K., Tong S.F., Lau A., Leung N., Hui A., Cheung K.M., Ko C.H., Chan Y.K., Ma O., Chau T.N., Chiu A. and Chan Y.W., Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: identification of 17 novel mutations and its genetic heterogeneity, Journal of Human Genetics. 2008, 53(1): 55-63. |
|
Sherman M., Rizzetto M., Lai C.L., Liaw Y.F., Gadano A.,
Jacobson I.M., Schiff E.R., Yang J., Colonno R., Kreter B. and Hindes R.,
Long-term follow-up of entecavir treated protocol-defined non responders in
rollover study ETV-901, Hepatology. 2007, 46(4):Suppl 1: |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S375. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S375. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B Virus Core-related Antigens as a Marker for Monitoring of Chronic Hepatitis B Infection, Journal of Clinical Microbiology. 2007, 45: 3942-3947. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B virus core-related antigens as a marker for monitoring of chronic hepatitis B infection., J Clin Microbiol . 2007, 45(12): 3942-7. |
|
Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yuan H.J., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E., Lai C.L. and Yuen R.M.F., Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B, J Infect . 2007, 54: 497-503. |
|
Yuen R.M.F. and Lai C.L., HBV genotypes: implications for treatment and management. , Expert Rev Gastroenterol Hepatol . 2007, 1(2): 321-328. |
|
Yuen R.M.F., Fong D.Y.T., Wong D.K.H., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response, Hepatology. 2007, 46: 1695-1703. |
|
Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
|
Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
|
Yuen R.M.F. and Lai C.L., Prediction of treatment outcome for lamivudine., Journal of Gastroenterology and Hepatology. 2007, 22(7): 964-5. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels, Gut. 2008, 57(1): 98-102. |
|
Yuen R.M.F. and Lai C.L., Telbivudine for chronic hepatitis B: The GLOBE trial. 2008;3(4):317-323., Future Virology. 2008, 3(4): 317-323. |
|
Researcher
: Lai KC |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Researcher
: Lai KN |
|
Project Title: |
The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN) |
|
Investigator(s): |
Lai KN, Leung JCK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To define the role of RAS in inducing PTEC/MC damage and; to elucidate the cross-talk between resident cells and infiltrating cells (T-cells/monocytes). |
|
Project Title: |
The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN) |
|
Investigator(s): |
Lai KN, Leung JCK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To determine whether there are known IgA receptors in the renal tubules; to determine the presence of any specific binding of pIgA from patients with IgAN to renal tubular epithelial cells; if there is no specific binding of IgA from IgAN to renal tubular epithelial cells, to find out where there are humoral or soluble factors from activated mesangial cells that induce tubular expression of proinflammatory mediators and the subsequent development of tubular epithelial-mesenchymal transdifferentiation; to explore which receptors for these proinflammatory mediators are present in renal tubules; to find out whether tubular damage is mediated via soluble factors alone or infiltrating T-cells/monocytes are also required. |
|
Project Title: |
Crosstalk between Podocytes and Mesangial Cells in IgAN |
|
Investigator(s): |
Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
IgA nephropathy (IgAN) is the major
leading cause of kidney failure worldwide. The disease is characterized by
the deposition of "pathogenetic" polymeric immunoglobulin A (pIgA)
in the glomerular mesangium followed by proliferation of the mesangial cell
(HMC) and infiltration of immunocompetent cells including T-cells and
monocytes. [1] IgAN runs a highly variable clinical course that is often
associated with progressive tubulointerstitial damage and subsequent renal
failure. The severity of tubulo- interstitial damage is a better prognostic
indicator of renal function than glomerular sclerosis, yet IgA deposits are
seldom detected in the tubulointerstitium. Although high-grade proteinuria
can lead to tubulointerstitial damage and progressive kidney failure in
glomerular disease, heavy proteinuria, notably, is not a common feature of
IgAN. Hence, the puzzling question is how do IgA deposits in glomerular
mesangial cells lead to subsequent tubulointerstitial damage and result in
terminal renal failure. Although the causes of kidney failure are diverse,
the glomerular filtration barrier is often the target of injury. This barrier
separates the blood from urinary spaces, and selectivity permits the removal
of excess water and solute while preventing the loss of critical blood
proteins such as albumin, immunoglobulins and clotting factors. The
filtration barrier consists of glomerular visceral epithelial cells
(podocytes) that are in intimate association with fenestrated glomerular
capillary endothelial cells, and are separated from each other by a thin
glomerular basement membrane (GBM) that measures only 0.3 micron. Glomerular
podocytes are highly differentiated cells that play a key role in maintaining
the integrity of the glomerular filtration barrier. Their interdigitating
foot processes cover the exterior surface of the glomerular basement membrane
and, in turn, stabilize the glomerular architecture. In glomerular diseases,
podocyte damage is associated with proteinuria and progressive loss of kidney
function. [2] Recent genetic studies have highlighted the importance of the
podocyte in disease processes that affect the glomerulus. A number of
podocyte proteins have been identified and genetic mutations of these podocyte
proteins are associated with congenital forms of nephrotic syndrome.[3,4]
These genetic breakthroughs have stimulated renewed interest in glomerular
epithelial cell biology, both in normal, congenital and acquired disease
states. As a consequence of the high degree of differentiation of podocytes
in analogy to neurons, these cells are unable to proliferate. An inability to
repopulate a damaged glomerulus with functional podocytes corresponds with
the progressive ultrastructural lesions seen in podocyte during filtration
barrier failure. Investigators from |
|
Project Title: |
The tubular peroxisome proliferator - activated receptors (PPAR) -γ system in IgA nephropathy: a potential therapeutic target |
|
Investigator(s): |
Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To test whether the PPAR system in renal
tubules is suppressed due to the glomerulo-tubular "cross-talk"
that operates in IgAN; to test whether PPAR-γ agonist suppresses the
expression of ATR |
|
List of Research Outputs |
|
Chan B.C.L., Ching A.K.K., To K.F., Leung J.C.K., Chen S., Li Q., Lai P.B.S., Tang N.L.S., Shaw P.C., Chan J.Y.H., James A.E., Lai K.N., Lim P.L., Lee K.K.H. and Chui Y.L., BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma, Oncogene. 2007, 27: 1208-17. |
|
Chan
D.T.M., Lin A.W., Tang S.C.W.,
Qian J.Q., Lam M.F., Ho Y.W., Tse K.C., Chan
K.W., Lai K.N. and Tang C.S.O., Prospective controlled
study on mycophenolate mofetil and prednisolone in the treatment of
membranous nephropathy with nephrotic syndrome, Nephrology. |
|
Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology. 2008, 13(4): 322-330. |
|
Chan G.S.W., Lam M.F., Au W.Y., Chim S., Tse K.C., Lo S.H., Fung S.H., Lai K.N. and Chan K.W., Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation, Nephrology (Carlton). 2008, 13(4): 322-30. |
|
Chan
G.S.W., Lam M.F., Au W.Y., Tse
K.C., Chim S., Fung S.H., Lo S.H.K., Lai K.N. and Chan K.W., Renal Pathology after
Haematopoietic Stem Cell Transplantation (HSCT): A study of 13 patients, 24th
World Congress of Pathology and Laboratory Medicine, 20-24 August 2007, |
|
Chan L.Y., Leung J.C.K., Zhang C., Tang S.C.W. and Lai K.N., Angiotensin II type 2
receptor-mediated ERK inhibition protects tubular epithelial cells from
pro-inflammatory damage, Journal of American Society of Nephrology.
2007, 18: |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Chan W.L., Leung J.C.K., Chan L.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects polymeric
IgA induced mesangial cells injury in IgAN: roles of smad6 and PPAR-gamma, Journal
of American Society of Nephrology. 2007, 18: |
|
Cheung S.C., Guo H., Leung J.C.K., Man K., Lai K.N. and Wu E.X., MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement, Magnetic Resonance in Medicine. 2008, 59: 1170-4. |
|
Feldt-Rasmussen B., Lange M., Sulowicz W., Gafter U., Lai K.N., Wiedemann J., Christiansen J.S., Nahas M.E. and and the APCD Study Group , Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk, Journal of American Society of Nephrology. 2007, 18: 2161-2171. |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Lai K.N., Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Lai F.M. and Tang S.C.W., Activation of podocytes by mesangial-derived TNF-{alpha}: glomerulo-podocytic communication in IgA nephropathy, American Journal of Physiology Renal Physiology. 2008, 294: F945-F955. |
|
Lai
K.N., B cell modulation in glomerular
disease, 11th Asian Pacific Congress of Nephrology, |
|
Lai K.N., Editorial Advisory Board, International Journal of Artificial Organs. 2008. |
|
Lai
K.N., Hepatitis C virus glomerulopathies, 11th Asian
Pacific Congress of Nephrology, |
|
Lai
K.N., Honorary Advisory Board, Australian
and |
|
Lai K.N., Managing Editor, Nephrology [Blackwell] (since 1999). 2008. |
|
Lai
K.N., Medicine [ |
|
Lai K.N., Member, Editorial Board, Nephron (Clinical Practice). 2008. |
|
Lan X.R., Chung A.C.K., Wang X.J., Lai K.N. and Lan H.Y., Mice Overexpressing Latent TGF-{beta}1 Are Protected against Renal Fibrosis in Obstructive Kidney Disease., American journal of physiology. Renal physiology. 2008, 295: F118-27. |
|
Leung
J.C.K., Tang S.C.W., Chan L.Y.,
Lam M.F. and Lai K.N., CTGF
regulation amongst peritoneal cells under the context of CAPD, Journal of
American Society of Nephrology. 2007, 18: |
|
Leung J.C.K., Chan L.Y., Tang S.C.W., Tam P.C., Fenn J. and Lai K.N., Glycosylation profile of differently charged IgA1 and their binding characteristics to cultured mesangial cells in IgA nephropathy, Nephron Experimental Nephrology . 2007, 107: 107-118. |
|
Leung
J.C.K., Tang S.C.W., Lam M.F., Chan Y.Y. and Lai K.N., Serum and spent peritonitis
fluid concentration of neutrophil gelatinase-associated lipocalin (NGAL) in
peritonitis, Peritoneal Dialysis International. |
|
Leung J.C.K., Tang S.C.W., Chan Y.Y., Chan W.L. and Lai K.N., Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA-role of MAPK and NFkB, Nephrology Dialysis Transplantation. 2008, 23: 72-81. |
|
Tang S.C.W., Leung J.C.K., Chan L.Y., Eddy A.A. and Lai K.N., ACEi suppresses angiotensin II-induced MAPK activation and TGF-β secretion in cultured PTEC, Proceedings of The World Congress of Nephrology. 2007, 368. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Eddy A.A. and Lai K.N., Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy, Kidney International. 2008, 73: 288-299. |
|
Tang S.C.W., Ho Y.W., Tang A.W.C., Cheng Y.Y., Chiu F.H., Lo W.K., Lai K.N. and and for the HK PDSG , Delaying initiation of dialysis till symptomatic uraemia--is it too late? , Nephrology Dialysis Transplantation. 2007, 22: 1926-1932. |
|
Tang S.C.W. and Lai K.N., Does automated peritoneal dialysis provide better outcomes than continuous ambulatory peritoneal dialysis?, Nature Clinical Practice Nephrology. 2007, 3: 596-597. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Tang
S.C.W., Leung J.C.K., Chan L.Y.,
Yuen Y.M. and Lai K.N.,
PPAR-gamma agonist reduces intrarenal injury and inflammation in genetically
diabetic db/db mice with accelerated glomerular and tubulo-interstitial
lesions, Journal of American Society of Nephrology. 2007, 18: |
|
Tang S.C.W. and Lai K.N., Tired but can’t sleep, Peritoneal Dialysis International. 2007, 27: 647-650. |
|
Tse K.C., Yung S.S.Y., Tang S.C.W., Tam S., Lai K.N. and Chan D.T.M., Atorvastatin at conventional dose did not reduce C-reactive protein in patients on peritoneal dialysis, Journal of Nephrology. 2008, 21: 283. |
|
Wang A.Y.M. and Lai K.N., Use of cardiac biomarkers in end-stage renal disease, Journal of American Society of Nephrology. 2008, 19: 1643-52. |
|
Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
|
Researcher
: Lai KWH |
|
List of Research Outputs |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Researcher
: Lai MH |
|
List of Research Outputs |
|
Lai M.H., Cheung C.L., Luk K.D.K. and Kung A.W.C., Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women, Osteoporosis International. 2007, 19: 571-9. |
|
Researcher
: Lam B |
|
List of Research Outputs |
|
Cheung T.K., Lam B., Ip M.S.M., Kung R., Ng C.Y.C. and Wong B.C.Y., Gastro-esophageal reflux disease negatively impacted on asthma control, quality of life and psychological status in Chinese asthma patients, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Ho J.C.M., Lam B., Ip M.S.M. and Lam W.K., Clinical Respiratory Medicine, 3rd edition, Hong Kong, 2007. |
|
Lam
B. and Lam
W.K., Approach to respiratory symptoms: III: haemoptysis, In Eds. Ho JCM,
Lam B, Ip MSM, Lam WK , Clinical Respiratory Medicine, 3rd Edition, 2007.
|
|
Lam B., Fung S.L., Lam D.C.L., Lui M.M.S., Yew W.W., Ip M.S.M. and Lam W.K., Initial experience of using flexi-rigid pleuroscopy for the diagnosis of exudative pleural effusion in Hong Kong, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Lam B., Medical approach on smoking cessation, Hospital Authority Steering Committee on Smoking Counseling and Cessation Programme, HAHO. 2007. |
|
Lam
B. and Ho
P.L., Opportunistic pulmonary infections, In Eds. Ho JCM, Lam B, Ip MSM,
Lam WK, Clinical Respiratory Medicine, 3rd Edition, 2007. |
|
Lam B., Practical tips to help patients to quit smoking in primary care setting, CME lecture for NTWC family doctors, Gold Coast Country & Yacht Club. 2007. |
|
Lam B., The Challenge of quitting : Strategies in Primary Care for Smoking Cessation, The Primary Care Clinic. 2007. |
|
Lam B., Sam K., Lai A.Y.K., Lam J.C.M., Lam D.C.L. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
|
Lam B., The leading role of doctors in in-patient smoking cessation, IANS Seminar in Promotion of In-patient Smoking Cessation, HAHO. 2007. |
|
Lam D.C.L. and Lam B., Approach to respiratory
Symptoms: I: cough, In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine,3rd Edition, 2007. |
|
Lam D.C.L., Lam B. and Ip M.S.M., Chronic obstructive pulmonary
disease. In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory
Medicine, 3rd Edition, 2007. |
|
Lam J.C.M., Lam B. and Ip M.S.M., Sleep apnea hypopnea
syndrome. In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory
Medicine, 3rd Edition, 2007. |
|
Wang J.K.L. and Lam B., Bronchopulmonary infections,
In Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical Respiratory Medicine, 3rd
Edition, 2007. |
|
Wong M.K., Wong M.P., Lam D.C., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2008. |
|
Researcher
: Lam CLK |
|
Project Title: |
Effectiveness of Traditional Chinese Medicine in Primary Care |
|
Investigator(s): |
Lam CLK, Leung KF |
|
Department: |
Med - Family Medicine Unit |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Primary health care has important
contributions to the health of the population by managing over 90%of the
illnesses of the population. Although Western medicine is the established
system of health care in Hong Kong, 50 to 60% of people in |
|
Project Title: |
A randomized, double blind, placebo-controlled clinical trial of Chinese herbal medicine in the treatment of acute upper respiratory infections |
|
Investigator(s): |
Lam CLK, Wong W, Fong DYT |
|
Department: |
Med - Family Medicine Unit |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The aim of this study is to test if Chinese herbal medicine (CHM) guided by Traditional Chinese medicine (TCM) diagnosis will significantly increase recovery rate, and reduce the duration and/or severity of symptoms, and improve the quality of life of patients with URTIs in primary care. |
|
Project Title: |
Translation and Validation of the Chronic Liver Disease Questionnaire (CLDQ) for Chinese patients with Chronic Hepatitis B Infection in Hong Kong |
|
Investigator(s): |
Lam CLK, Lai CL, Yuen RMF |
|
Department: |
Med - Family Medicine Unit |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
Introduction More than 2 billion people
have been infected with hepatitis B in the world[1], with an estimated 350
million being chronic carriers and approximately 250-300 million of whom are
Chinese. Without treatment, infected individuals may progress through the
different stages of liver disease from uncomplicated HB carriers, to chronic
hepatitis, to cirrhosis, liver failure and/ or hepatocellular carcinoma
(HCC). Chronic hepatitis infection can adversely affect mental and physical
health leading to impairment of quality of life (QOL)[2-4]. Younossi et al
found an association between scores in HRQOL and the severity of the liver
disease[4]. HRQOL has become an important outcome indicator in clinical
services and health policies in the last two decades. HRQOL measures can be
categorized broadly into two types: generic and disease-specific. Generic
measures are applicable to people of all health status and allow comparison
between different types of diseases. However, they may not be able to detect
small but clinically important differences in HRQOL that are specific to
certain diseases, such as fatigue in chronic liver disease. Therefore, a
disease-specific measure may be needed to supplement a generic measure to
assess the HRQOL of patients with a particular disease. Several HRQOL
measures have been developed specific for chronic liver disease patients,
such as the Chronic Liver Disease Questionnaire (CLDQ)[5], the Hepatitis
Quality of Life (HQLQ)[6], and the Liver Disease Quality of Life (LDQOL)[7].
The Chronic Live Disease Quality of Life (CLDQ) is the first available
disease specific HRQOL measure for chronic liver disease (CLD) developed by
Younossi et al. It is applicable to patients with different types of chronic
liver diseases. It has been shown to have good reliability, validity and
sensitivity, and has been validated in different cultures including Italian,
German, Chinese (Simplified format) and Thai [8-12]. Therefore, the CLDQ has
been shown to be suitable for cross-cultural adaptation. It captures
important areas and problems relating to HBV infection, such as, fatigue. The
CLDQ has only 29 items and can be completed in less than 15 minutes. The
other two liver disease specific HRQOL measures are less widely used because
they are much longer, have less validation data and have been tested only on
patients with specific types of chronic liver diseases. In |
|
List of Research Outputs |
|
Chen
R.Q., Lam C.L.K., Wong C.M., Cao K. and Lam T.H., The HRQoL measured by SF |
|
Fong D.Y.T., Ho D.S.Y., Mak K.K., Lo W.S., Lai Y.K., Lam T.H. and Lam C.L.K., Confirmatory Factor Analysis of the SF-12 Health Survey in Chinese Adolescents, Asian Chinese Quality of Life Conference. 2008. |
|
Lam
C.L.K., Lee
P.W.H., Fong D.Y.T. and Lam T.P., A randomised controlled trial
on the effectiveness of screening and brief problem-solving counselling for
elderly patients with undiagnosed psychological problems in primary care., Hong
Kong Medical Journal. HK |
|
Lam
C.L.K., Invited Workshop on ‘
Preference-based Measure of Health (PBMH) by Standard Gamble’. , Asian
Chinese Quality of Life Conference, |
|
Lam C.L.K., Member, Editorial Board, Cases Journal. Biomed Central, 2008. |
|
Lam
C.L.K., Paper on ‘MUS of Chinese Patients
Presenting to Primary Care’. , MUS in Family Medicine-the State of |
|
Lam
C.L.K., Plenary paper on "Clinical and
Interpersonal Skills - Tricks of the Trade"., Frontiers in Medical
Education HKU 2007. Li Ka Shing Faculty of Medicine. |
|
Lam
C.L.K., Plenary paper on "Family
Medicine Research in Asia", 23rd Annual Scientific Assembly of the |
|
Lam
C.L.K., Plenary paper on
"Preference-based Measure of the 'Q' of QALYs., Asian Chinese Quality
of Life Conference. |
|
Lam
C.L.K., Plenary paper on "The
Contribution of Research to the Roles of Family Doctors", 23rd Annual
Scientific Assembly of the |
|
Lam
C.L.K., Plenary paper on "The Family in
Family Medicine"., Inaugural Symposium, Consortium of Institutes on
Family in Asian Region. |
|
Lam
C.L.K., Quality Primary Health Care. , Forum
on the Health Care Reform Consultation Document. |
|
Lam
C.L.K., Symposium presentation on ‘Education
in FM/GP- The Asia-Pacific Perspective’, , 18th WONCA World Conference,
July 24-27, 2007, |
|
Lam C.L.K., Brazier J. and McGhee S.M., Valuation of the SF-6D Health States is Feasible, Acceptable, Reliable, and Valid in a Chinese Population. , Value in Health. 2008, 11: 295-303. |
|
Lam
C.L.K., Lee
P.W.H., Fong D.Y.T. and Lam C.L.K., “Screening and Brief
Problem-solving Counselling had Short-term Benefit for Elderly Patients with
Undiagnosed Psychological Problems in Primary Care”. , |
|
Lam
C.L.K., Plenary lecture on 家庭醫學中的科研 - 與眾不同., 中華醫學會全科醫學分會學術年會, |
|
Lam C.L.K., 全科医疗中的临床診断與处理。, In: 梁万年主编, 全科医學概论, Beijing,China, 中国北京人民卫生出版社, 2007, 第äºç: 第十二章. |
|
Lam
T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., Leung G.M. and McGhee S.M., Health-related Quality of
Life of Patients with Chronic Hepatitis B Infection. Oral, 2008 Asian
Chinese Quality of Life Conference. |
|
Lam
T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics
of the Chinese (Hong Kong) version of the chronic liver disease
questionnaire. Poster, 2007 International Society for Quality of Life
Research Annual meeting. |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics of the Chinese (Hong Kong) version of the chronic liver disease questionnaire, Quality of Life Research. 2007, A-48, Abstract #1472. |
|
Wong
O.L., Kuntz K.M., Cowling B.J., Lam C.L.K. and Leung G.M., Cost effectiveness of
mammography screening for Chinese women in Hong Kong (abstract), Hong
Kong College of Community Medicine Annual Scientific Meeting, 8 September
2007, Hong Kong. Hong Kong, |
|
Wong O.L., Kuntz K.M., Cowling B.J., Lam C.L.K. and Leung G.M., Cost effectiveness of mammography screening for Chinese women, cancer. 2007, 110: 885-895. |
|
Wong
O.L., Cowling B.J., Kuntz K.M., Schooling C.M., Lam C.L.K. and Leung G.M., How will future changes in
breast cancer incidence affect the cost-effectiveness of mammography
screening in |
|
Wong
W., Lam C.L.K. and Fong D.Y.T., A Randomized, Double Blind,
Placebo-controlled Clinical Trial of Chinese Herbal Medicine in the Treatment
of Acute Upper Respiratory Infections, 3rd
International Congress on Complementary Medicine Research. |
|
Wong
W. and Lam C.L.K., Chinese
Patients' Experience in Randomized Clinical Trail-A Comparison of Western
Medicine and Chinese Medicine Clinical Trials, 3rd
International Congress on Complementary Medicine Research. |
|
Wong
W. and Lam C.L.K., Chinese
patients' experience in clinical trial-A comparison of Western medicine and
Chinese medicine clinical trials, Postgraduate Symposium of the 2007 TWGHs
Eddie Wang Symposium on Integrated Chinese and Western Medicine. |
|
Wong
W. and Lam C.L.K., Did the
Chinese Quality of Life Instrument applicable to Western medicine health
services in Chinese population?, 2008 Asian Chinese Quality of Life Conference.
|
|
Wong W., Lam C.L.K., Leung K.F. and Zhao L., Is the Content of the Chinese Quality of Life Instrument (ChQOL) Really Valid in the Context of Traditional Chinese Medicine in Hong Kong?, Complementary Therapies in Medicine . 2008. |
|
Wong
W. and Lam C.L.K.,
Presentation award from the scholarship of the |
|
Wun Y.T., Tse E.Y.Y., Lam T.P. and Lam C.L.K., PBL Curriculum Improves Medical Students' Participation in Small-group Tutorials., Medical Teachers. 2007, 29: e198 - e203 (I.F. 1.229). |
|
Researcher
: Lam CW |
|
List of Research Outputs |
|
Mak C.M., Kwong Y.L., Lam C.W., Chan S.C., Lo C.M., Fan S.T., Chang P.C.M., Lau Y.K., Lok Sun U. and Tam S., Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese, Amyloid. 2007, 14(4): 293-297. |
|
Researcher
: Lam KSL |
|
Project Title: |
Genetic and hormonal influences on phenotypic expression of apolipoprotein (a) |
|
Investigator(s): |
Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Outstanding RGC Projects |
|
Start Date: |
11/1998 |
|
Abstract: |
|
To enhance research level. |
|
Project Title: |
Linking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones |
|
Investigator(s): |
Lam KSL, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2004 |
|
Abstract: |
|
To determine whether serum levels of adiponectin are predictive of progressive atherosclerosis in man in a 5-year prospective study; to establish a sensitive ELISA method for accurate quantification of human PGAR and investigate the relationship of serum PGAR levels with obesity, insulin resistance, glucose tolerance, blood pressure, lipid levels and progression in carotid atherosclerosis; to investigate the effects of adenovirus-mediated chronic administration of adiponectin or PGAR on glucose and lipid metabolism, and development of atherosclerosis in db/db mice, an animal model of the metabolic syndrome. |
|
Project Title: |
Application for seed fund for the strategic theme on healthy ageing |
|
Investigator(s): |
Lam KSL, Che CM, Lee TMC, Lee WWM, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
05/2005 |
|
Abstract: |
|
To integrate the existing strengths in aging related research within HKU through the identification of important themes of common interest; to provide core platforms for interdisciplinary research on aging diseases; to develop novel therapeutic approaches for the promotion of healthy aging. |
|
Project Title: |
Macrophage-adipocyte cross-talk in the initiation of obesity-related insulin resistance and type 2 diabetes: role of adiponectin |
|
Investigator(s): |
Lam KSL, Xu A, Lao TTH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To determine the time course and magnitude of macrophage infiltration in fat tissue, changes in the blood and fat tissue levels of adiponectin, pro-inflammatory cytokines and other adipocyte-derived hormones, in relation to changes in glucose tolerance and insulin sensitivity, in db/db mice; to investigate, in db/db mice, an animal model of genetically predisposed obesity and type 2 diabetes, whether the therapeutic use of adiponectin can prevent or reduce the above pro-inflammatory changes, insulin resistance and/or type 2 diabetes; to confirm whether the inflammatory and hormonal changes in the blood and fat tissue of obese mice, and their correlation with glucose tolerance and insulin sensitivity, are also observed in overweight or obese Chinese subjects; to determine, in type 2 diabetic patients, the contribution of changes in circulating adiponectin to the anti-inflammatory and insulin-sensitizing actions of rosiglitazone, a PPAR-γ agonist which can increase adiponectin expression |
|
Project Title: |
Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese |
|
Investigator(s): |
Lam KSL, Xu J, Xu A |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2005 |
|
Abstract: |
|
The angiopoietin like protein-4 (ANGPTL4) is a hormone, predominantly derived from fat cells, which has been recently shown by our group to decrease blood glucose and hepatic insulin resistance in rodents. The purpose of this project is to determine whether the ANGPTL4 gene plays a significant role in the genetic susceptibility to diabetes and other insulin resistance related traits in humans, using blood and DNA samples collected from on-going cross-sectional and prospective studies.Objectives1. To systematically search for polymorphisms in the human ANGPTL4 gene in southern Chinese2. To perform case control association studies of ANGPTL4 polymorphisms and haplotypes with the risk of T2DM, obesity, insulin resistance, and hyperlipidemia 3. To investigate the role of ANGPTL4 polymorphisms and haplotypes in predicting the development of diabetes in a 10- year prospective follow-up study of 600 non-diabetic subjects4. To determine the role of genetic polymorphisms in regulating circulating ANGPTL4 levels |
|
Project Title: |
Adipocyte fatty acid binding proteins: new mediators of the metabolic syndrome and coronary atherosclerosis |
|
Investigator(s): |
Lam KSL, Xu A, Sham PC, Lao TTH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
08/2006 |
|
Abstract: |
|
(1) To investigate the genetic regulation of circulating FABP4 and FABP5 levels in man by examining the effects of genetic variants detected from a systematic analysis of the two genes (2) To investigate (a) the associations of genetic variants/serum levels of FABP4 and FABP5 with the metabolic syndrome or its components (Obesity, insulin resistance, dyslipidaemia, glucose intolerance/diabetes, hypertension, chronic inflammation), and coronary atherosclerosis, in cross-sectional and prospective studies, and (b) whether FABP4 and FABP5 interact at genetic or circulating protein levels in such associations (3) To examine the relationship of circulating FABP4 and FABP5 levels with their gene and protein expressions in visceral and subcutaneous adipose tissues, and insulin sensitivity indices (4) To investigate why circulating FABP4 levels are higher in women. |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, 2nd Joint Scientific Meeting of the Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, 27-28 October 2007, Hong Kong. 2007. |
|
Chiu S.S.H., Pang C.B.Y., Lam K.S.L. and Khong P.L., Variability of coronary artery calcium scoring using 64-slice MDCT, Best Poster Award at 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. 2007. |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
|
Chu L.W., Tam S., Kung A.W.C., Lo S., Fan S., Wong L.C., Morley J.E. and Lam K.S.L., Serum total and bioavailable testosterone levels, central obestiy and muscle strength changes with aging in healthy Chinese men, Journal of American Geriatrics Society. 2008, 56(7): 1286-1291. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis , 13 th Medical Research Conference, The University of Hong Kong. 2008. |
|
Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis, 13th Medical Research Conference, HKU, 19 Jan 2008, Hong Kong. 2008. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Hoo R.L.C., Yeung C.Y., Lam K.S.L. and Xu A., Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid binding protein, In: Future drugs Ltd, Expert Rev. Endocrinol. Metab.. 2008, 3: 29-41. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Lam
K.S.L., Wat
N.M.S., Tso A.W.K., Fong H.Y. and
Xu A., Additive effects of
adiponectin and C-reactive protein in predicting the risk of type 2 diabetes:
a 10-year prospective study. , 43rd Annual Meeting of the EASD,17-21
September 2007, |
|
Lam
K.S.L., Advances in the management of
diabetes. (Plenary lecture), 1st Beijing-Hong Kong Medical Forum, |
|
Lam K.S.L., Associate Editor, Chinese Journal of Diabetes. 2007. |
|
Lam K.S.L., Associate Editor, Diabetes Research & Clinical Practice. 2007. |
|
Lam K.S.L., Associate Editor, Diabetes, Obesity & Metabolism. 2007. |
|
Lam
K.S.L., Associate Editor, Diabetic
Medicine. |
|
Lam K.S.L., Associate Editor, Obesity Research & Clinical Practice. 2007. |
|
Lam K.S.L., Associate Editor, The Diabetic Foot. 2007. |
|
Lam
K.S.L., Diabetes in Chinese: Changing
Epidemiology, Prediction and Preventive Measures. , Magnuson Congress, |
|
Lam K.S.L., Editorial Board Member, Diabetes, Obesity & Metabolism. Blackwell, 2008. |
|
Lam K.S.L., Excellent Research Award, Health Services Research Fund, HKSAR Food & Health Burea. 2007. |
|
Lam
K.S.L., Novel adipokines in the prediction
and treatment of cardiometabolic risk., 2007 Annual Symposium of Korean
Society for the Study of Obesity, |
|
Lam
K.S.L., Obesity and cardiometabolic risk in
diabetes. (Keynote lecture), 7th IDF-WPR Congress, |
|
Lam
K.S.L., Predicting the development of
diabetes in Hong Kong Chinese., |
|
Lau
T.Y.I., Ye H.Y., Xu A. and Lam K.S.L., Macrophage-adipocyte
cross-talk in the initiation of obesity-related insulin resistance and type
2diabetes. , 43rd Annual Meeting of the EASD, 17-21 September 2007, |
|
Li H., Li X., Lam K.S.L., Tam S., Xiao W. and Xu R., Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats, J Biomed Sci.. 2008, Epub ahead of print. |
|
Liu L., Wang Y., Lam K.S.L. and Xu A., Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications, Endocr Metab Immune Disord Drug Targets (Invited review). 2008, 8: 89-98. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
|
Ong K.L., Tso A.W.K., Lam K.S.L. and Cheung B.M.Y., Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension, Hypertension. 2008, 51: 1142-8. |
|
Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Tso A.W.K., Xu A., Chow W.S. and Lam K.S.L., Adipose tissue and the metabolic syndrome: focusing on adiponectin and several novel adipokines, Biomarkers in Medicine. 2008, 2: 239-52. |
|
Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72. |
|
Wang Y., Lam K.S.L. and Xu A., Adipokines at the crossroad of obesity, inflammation and type 2 diabetes, Annual Meeting of Korean Endocrine Society. 2008. |
|
Wang Y., Lam K.S.L. and Xu A., Post-translational modifications of adiponectin: mechanisms and functional implications. , Biochemical Journal. 2008, 409: 623-33. |
|
Wat N.M.S., Lam T.H., Janus E.D. and Lam K.S.L., Impaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the Hong Kong Chinese population: a 5-year prospective study, Hong Kong Medical Journal. 2008, 14 (Suppl 3): S20-S22. |
|
Xu J.Y., Sham P.C., Xu A.M., Tso A.W.K., Wat N.M.S., Cheng K.Y., Fong C.H.Y., Janus E.D. and Lam K.S.L., Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study., Clinical Endocrinology. 2007, 66: 211-217. |
|
Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Yeung C.Y., Xu A., Cheung C.W.S., Wat N.M.S., Yau J.M.H., Fong H.Y., Chau M.T. and Lam K.S.L., Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology.. US, American Heart Association, 2007, 27: 1796-1802. |
|
Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
|
Zhou
M., Wang Y., Lam K.S.L., Tam P.K.H., Hoo R.L.C., Liu J. and Xu A., Increased Vulnerability to Liver
Injury is Associated with Decreased Mitochondrial Activities in Adiponectin
Knockout Mice: Potential Roles of UCP |
|
Zhu
W., Cheng K.Y., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Vascular effects of adiponectin:
molecular mechanisms and potential therapeutic intervention, Clin Sci ( |
|
List of Research Outputs |
|
Au W.Y., Pang A.W.K., Lam K.Y., Song Y., Lam W.M., So J.C.C. and Kwong Y.L., G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors, Bone Marrow Transplantation. 2007, 40(7): 677-681. |
|
Project Title: |
Chemoprevention of gastric cancer by intervention with Helicobacter pylori and cyclooxygenase pathway |
|
Investigator(s): |
|
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2001 |
|
Abstract: |
|
To assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors in asymptomatic individuals can reduce the incidence of gastric cancer in a high risk area over a five to ten year period; to assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors will lead to progression or regression of various precancerous gastric conditions including gastric atrophy, intestinal metaplasia and dysplasia over a three year period; to assess the long term sequelae of Helicobacter pylori eradication and use of specific cyclooxygenase-2 inhibitors histologically, including changes in cell proliferation, apoptosis and oncogene expressions. |
|
Project Title: |
Biotech Company
in the Faculty of Medicine, The University of |
|
Investigator(s): |
|
|
Department: |
Medicine |
|
Source(s) of Funding: |
The |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To enable the Faculty of Medicine of The University of Hong Kong to establish itself as the regional centre of excellence in the provision of complete solutions to industry from laboratory research services to clinical trials, setting standards and quality benchmarks comparable to the best international practices for other similar centres in the region to follow. |
|
Project Title: |
Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system |
|
Investigator(s): |
|
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2004 |
|
Abstract: |
|
To elucidate the molecular mechanisms of survivin in tumor angiogenesis, to will investigater the effect of overexpression of survivin on the migration and capillary tuber-like networks of endothelial cells, expression of angiogenic factors in gastrointestinal cancer cells and angiogenesis in Chorioallantoic membrane angiogenesis (CAM) model and nude mice xenograft; to establish a novel gene therapy for gastrointestinal cancer by targeting survivin gene with adeno-associated virus vector. We will further study the therapeutic effect of rAAV-mediated survivin mutant on gastrointestinal cancer in vivo and evaluate long-term effect and safety of the rAAV virus. |
|
Project Title: |
The prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in Hong Kong Chinese |
|
Investigator(s): |
|
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To study the prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in Chinese patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in patients with GERD. |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Lee A.M., Lam S.K., Lau S.M.S.M., Chui H.W., Fong D.Y.T., Kwan C.W., Chong C.S.Y. and Tang L.C.H., Prevalence, course and risk factors of disordered eating during pregnancy and in the postpartum period, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007. |
|
Researcher
: Lam TP |
|
Project Title: |
What are the
stigmatizing opinions about people with mental health problems among |
|
Investigator(s): |
Lam TP |
|
Department: |
Med - Family Medicine Unit |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Objectives of the proposed study:1. To
investigate the stigmatizing opinions towards patients of different common
mental illnesses e.g. anxiety related conditions, depression, schizophrenia,
drug and alcohol abuse, and dementia.2. To investigate if health care
attendance by family physicians with special training in mental health
instead of specialist psychiatrists for minor mental illnesses e.g. anxiety,
depression, would affect the readiness of some Hong Kong patients to seek
treatment and to continue follow up for their illnesses.According to the US
Surgeon General, stigma is the number one barrier to mental health care and
this has been supported by recent studies (1). There is also evidence that
stigmatizing opinions about people with psychiatric disorders are widely held
in the |
|
Project Title: |
Is there a need
to promote family medicine concept in |
|
Investigator(s): |
Lam TP, Li DKT, Lam KF |
|
Department: |
Med - Family Medicine Unit |
|
Source(s) of Funding: |
Public Policy Research |
|
Start Date: |
04/2007 |
|
Abstract: |
|
1) To collect in-depth views of some members of the public towards family medicine through focus group interviews. 2) To describe the general public views towards family medicine through a territory wide cross-sectional study, with specific reference to treatment of depression. 3) To describe the relationship between the demographic factors of the public and their views towards family medicine. 4) To describe the doctors' views towards family medicine concept. 5) To describe the relationship between the demographic factors of the doctors and their views towards family medicine. |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Hong T.C., Lam T.P. and Chao D.V.K., 2008 Hong Kong College of
Family Physicians Best Research Award for a study on " Barriers for
primary care physicians in providing palliative care service in Hong
Kong".. , |
|
Hong T.C., Lam T.P. and Chao D.V.K., 41. Barriers for Primary
Care Physicians in providing Palliative Care Service in Hong Kong,, 14th |
|
Lam
C.L.K., Lee P.W.H., Fong D.Y.T. and Lam T.P., A randomised controlled
trial on the effectiveness of screening and brief problem-solving counselling
for elderly patients with undiagnosed psychological problems in primary
care., Hong Kong Medical Journal. HK |
|
Lam
T.P., 5-year Experience of a Postgraduate
Diploma Course in Psychological Medicine, 13th |
|
Lam T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., Leung G.M. and McGhee S.M., Health-related Quality of
Life of Patients with Chronic Hepatitis B Infection. Oral, 2008 Asian
Chinese Quality of Life Conference. |
|
Lam T.P., Researching psychological problems in primary care., Society of Bipolar and Affective Disorder. 2008. |
|
Lam T.P., Scholarship at the Asian Chinese Quality of Life Conference for being one of the best five abstracts. 2007. |
|
Lam T.P., The award of the best poster presentation at the
International Society for Quality of Life Conference. |
|
Lam
T.P., Lam
K.F. and Tse E.Y.Y., The
preferred mode of teaching and examination of primary care doctors
undertaking postgraduate diploma studies in Hong Kong., Hong Kong
Practitioner . Hong Kong, The |
|
Lam
T.P., Training of general practitioners in
psychological medicine: experience at the |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics
of the Chinese (Hong Kong) version of the chronic liver disease
questionnaire. Poster, 2007 International Society for Quality of Life
Research Annual meeting. |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics of the Chinese (Hong Kong) version of the chronic liver disease questionnaire, Quality of Life Research. 2007, A-48, Abstract #1472. |
|
Lam
T.P., In: Co-Editor of |
|
Luke
K.K., Lam T.P. and Zhang
W., Electronic Medical Record Keeping and Doctor-Patient Interaction: An
Analysis of Medical Consultation in |
|
Wun Y.T., Tse E.Y.Y., Lam T.P. and Lam C.L.K., PBL Curriculum Improves Medical Students' Participation in Small-group Tutorials., Medical Teachers. 2007, 29: e198 - e203 (I.F. 1.229). |
|
Researcher
: Lam TP |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Hong T.C., Lam T.P. and Chao D.V.K., 2008 Hong Kong College of
Family Physicians Best Research Award for a study on " Barriers for
primary care physicians in providing palliative care service in Hong
Kong".. , |
|
Hong T.C., Lam T.P. and Chao D.V.K., 41. Barriers for Primary
Care Physicians in providing Palliative Care Service in Hong Kong,, 14th |
|
Lam
C.L.K., Lee P.W.H., Fong D.Y.T. and Lam T.P., A randomised controlled
trial on the effectiveness of screening and brief problem-solving counselling
for elderly patients with undiagnosed psychological problems in primary
care., Hong Kong Medical Journal. HK |
|
Lam
T.P., 5-year Experience of a Postgraduate
Diploma Course in Psychological Medicine, 13th |
|
Lam T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., Leung G.M. and McGhee S.M., Health-related Quality of
Life of Patients with Chronic Hepatitis B Infection. Oral, 2008 Asian
Chinese Quality of Life Conference. |
|
Lam T.P., Researching psychological problems in primary care., Society of Bipolar and Affective Disorder. 2008. |
|
Lam T.P., Scholarship at the Asian Chinese Quality of Life Conference for being one of the best five abstracts. 2007. |
|
Lam T.P., The award of the best poster presentation at the
International Society for Quality of Life Conference. |
|
Lam
T.P., Lam
K.F. and Tse E.Y.Y., The
preferred mode of teaching and examination of primary care doctors
undertaking postgraduate diploma studies in Hong Kong., Hong Kong
Practitioner . Hong Kong, The |
|
Lam
T.P., Training of general practitioners in
psychological medicine: experience at the |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics
of the Chinese (Hong Kong) version of the chronic liver disease
questionnaire. Poster, 2007 International Society for Quality of Life
Research Annual meeting. |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics of the Chinese (Hong Kong) version of the chronic liver disease questionnaire, Quality of Life Research. 2007, A-48, Abstract #1472. |
|
Lam
T.P., In: Co-Editor of |
|
Luke
K.K., Lam T.P. and Zhang
W., Electronic Medical Record Keeping and Doctor-Patient Interaction: An
Analysis of Medical Consultation in |
|
Wun Y.T., Tse E.Y.Y., Lam T.P. and Lam C.L.K., PBL Curriculum Improves Medical Students' Participation in Small-group Tutorials., Medical Teachers. 2007, 29: e198 - e203 (I.F. 1.229). |
|
Researcher
: Lam WK |
|
List of Research Outputs |
|
Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
|
Chan
W.M. and Lam W.K.,
Respiratory failure and acute respiratory distress syndrome, In Eds. Ho JCM,
Lam B, Ip MSM, Lam WK, Clinical Respiratory Medicine, 3rd Edition, 2007.
|
|
Ho J.C.M., Wang J., Wong M. and Lam W.K., A phase II study of vinorelbine monotherapy in the treatment of advanced non-small cell lung cancer in elderly Chinese population. 12th World Conference on Lung Cancer., Journal of Thoracic Oncology 2007;2(8) Suppl 4.. 2007, S675. |
|
Ho J.C.M., Lam B., Ip M.S.M. and Lam W.K., Clinical Respiratory Medicine, 3rd edition, Hong Kong, 2007. |
|
Ho J.C.M., Lo R.L.K., Lam W.K. and Kwong Y.L., Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., AJRCCM 2008;177(10) Suppl. 2008, A463. |
|
Lam B.
and Lam W.K., Approach to
respiratory symptoms: III: haemoptysis, In Eds. Ho JCM, Lam B, Ip MSM, Lam WK
, Clinical Respiratory Medicine, 3rd Edition, 2007. |
|
Lam
B., Fung S.L., Lam D.C.L., Lui M.M.S., Yew W.W., Ip M.S.M. and Lam W.K., Initial experience of using
flexi-rigid pleuroscopy for the diagnosis of exudative pleural effusion in |
|
Lam D.C.L., Ho J.C.M. and Lam W.K., Carcinoma of the bronchus,
In: JCM Ho, B Lam, MSM Ip, WK Lam, Clinical Respiratory Medicine. |
|
Lam J.C.M. and Lam W.K., Approach to respiratory
symptoms: II: dyspnoea, In: Eds Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007. |
|
Lam
W.K. and Ip
M.S.M., Clinical curriculum, In: Eds. Ho JCM, Lam B, Ip MSM, Lam WK, Clinical
Respiratory Medicine, 3rd Edition, 2007 . |
|
Lo R.L.K., Lam W.K., Kwong Y.L. and Ho J.C.M., Best poster - Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., 13th Medical Research Conference. 2008. |
|
Mak
J.C.W., Ho S.P., Yu W.C., Choo
K.L., |
|
Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
|
Wong M.K., Wong M.P., Lam D.C., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2008. |
|
Researcher
: Lam YM |
|
List of Research Outputs |
|
Hwang Y.Y., Fan K., Lam Y.M., Chan W.S., Cheung S.C.W., Wang E.P. and Au W.Y., Primary cardiac lymphoma presenting with right heart mass and bradycardia, Annals of Hematology. 2007, 86(9): 685-6. |
|
Mok
T.M.Y., Fung P.C.W., Ooi C., Tse H.F., Wong Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
|
Researcher
: Lan HY |
|
Project Title: |
Role of smad signaling in regulation of CTGF expression under diabetic conditions |
|
Investigator(s): |
Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2006 |
|
Abstract: |
|
The main objectives of this project are
to: (1) examine the regulating role of Smad signaling in CTGF expression
under diabetic; (2) dissect the specific role of Smad2 and Smad |
|
Project Title: |
Regulation of immune response in glomerulonephritis by TGF-β/smad signaling |
|
Investigator(s): |
Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
(1) To demonstrate that Smad3 plays a pivotal role in the pathogenesis of anti-GBM GN. (2) To determine the mechanisms by which Smad3 regulates T cell immune responses in vivo and in vitro. |
|
Project Title: |
C-Reactive Protein in hypertensive cardiovascular disease |
|
Investigator(s): |
Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
Cardiovascular disease (CVD) is the most severe complication in hypertension. Recent studies have suggested that a native protein within the body called c-reactive protein (CRP) is markedly increased in patients with coronary heart disease and atherosclerosis and is a marker of CVD. Thus, the serum levels of CRP have been used clinically as diagnostic and predictor marker of CVD. However, it remains uncertain that CRP is causally related to CVD and the functional role of this molecule in CVD is largely unknown. We hypothesize that CRP may function as either pro-inflammatory or anti-inflammatory molecule in causing or counter-regulating the development of CVD. We plan to test this hypothesis in a mouse model of angiotensin II-induced hypertensive CVD in mice that do or do not over expressed CRP. The potential role of CRP in hypertensive CVD will be studied by examining cardiac function, inflammatory response, and fibrosis. We expect CVD to be promoted in mice that are overexpressing CRP, demonstrating a pathogenic role of CRP in CVD. However, it is also possible that CVD is protected in CRP Tg mice. If this occurs, it will indicate that CRP may act as an antagonist of inflammatory mediator and plays a protective role in angiotensin II-induced hypertensive CVD. In both cases, what mechanisms by which CRP exerts its pathogenic or protective role in CVD will be further investigated. Furthermore, it is also possible that CRP Tg mice cause no difference in terms of cardiovascular injury. This will suggest that CRP may service as a reactive protein and has no role in CVD. Nevertheless, whatever the results are, they are novel and meaningful. |
|
List of Research Outputs |
|
Chung A.C.K., Lan X.R., Zhou L., Heuchel R. and Lan H.Y., Loss of Smad7 Promotes Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 11th Asian Pacific Congress of Nephrology. 2008. |
|
Chung
A.C.K., Lan X.R., Zhou L. and Lan H.Y., Loss of Smad7 Promotes
Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in
Mice, 13th Medical Research Conference of Department of Medicine ( |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Lan H.Y., Immunopathologic Mechanisms Relevant to Disease, In: Richard Bucala, MIF, A Most Interesting Factor. Word Scientific Publishing Co Pte Ltd, 2007, 35-50. |
|
Lan
H.Y., Ace2, A Good Guy In Hypertensive Kidney
Disease, Dialysis Forum, |
|
Lan
H.Y., Advances In Gene Therapy And Targeting Using
Ultrasound-microbubble Delivery System, IEEE International Conference on
Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2007). 2007, |
|
Lan
H.Y., Advances In Molecular Pathology And
Therapy For Hypertensive Cardiovascular Disease, The 16th Asian Pacific
Congress of Cardiology (16th APCC), |
|
Lan H.Y., Associate Editor, Nephron Experimental Nephrology. 2007. |
|
Lan
H.Y., Latent Tgf-1
Is A Good Guy In Kidney Disease, Renal Grand Rounds, Baylor College of
Medicine, Houston, USA, |
|
Lan H.Y., Mechanisms Of Hypertensive And Diabetic Nephropathy, Southern Guandong Society of Nephrology, Kaiping, Guangdon, 13/10//2007. . 2007. |
|
Lan H.Y. and Johnson R.J., Mechanisms of tissue scarring: role of Smad signaling, In: William Mitch , Principles of Molecular Medicine. The Humana Press Inc, 2007. |
|
Lan H.Y., Molecular Pathology And Gene Therapy For Hypertensive Vascular Disease, The 10th South China International Congress of Cardiology (SCICC), Guangzhou, China, 10-13/4, 2008. 2008. |
|
Lan
H.Y., Molecular Pathology of Diabetic
Nephropathy, Guangxi Society of Nephrology, Naning, |
|
Lan
H.Y., Regulation Of T Cell-mediated Immune
Response By Tgf-1, |
|
Lan
H.Y., Regulation of renal inflammation and
fibrosis by TGF-beta, O’Brien Kidney Research Center, Baylor College of
Medicine, Houston, USA, |
|
Lan H.Y., Smad7 as a therapeutic agent for chronic kidney diseases, Front Biosci. 2008, 13: 4984-92. |
|
Lan H.Y., TGF-β Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7, In: Sonia B. Jakowlew, Cancer Drug Discovery and Development: Transforming Growth Factor-β in Cancer Therapy. Totowa, NJ, Humana Press Inc., 2007, Vol.1: 607-617. |
|
Lan
H.Y., Tgf-beta Is Not Always A Bad Guy In
Kidney Disease, West China Hospital, Sichuan University. 2007, |
|
Lan X.R., Chung A.C.K., Wang X.J., Lai K.N. and Lan H.Y., Mice Overexpressing Latent TGF-{beta}1 Are Protected against Renal Fibrosis in Obstructive Kidney Disease., American journal of physiology. Renal physiology. 2008, 295: F118-27. |
|
Lan X.R., Chung A.C.K., Zhou L., Li A.G., Wang X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis., 43th Annual Meeting Of Australian New Zealand Society Of Nephrology, Gold Coast, Australia (8-12 Sep, 2007). 2007. |
|
Lan X.R., Chung A.C.K., Zhou L., Wong X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis, Journal Of American Society Of Nephrology. 2008, 19: 233-242. |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective Role Of Latent
Tgf-beta |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective role of latent
Transformating Growth Factor-beta |
|
Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Menke J., Zeller G.C., Kikawada E., Means T.K., Lan X.R., Lan H.Y., Lu B., Farber J., Luster A.D. and Kelley V.R., CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease, J Am Soc Nephrol.. 2008, 19: 1177-89. |
|
Menke J., Lucas J.A., Zeller G.C., |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
|
Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Wang W., Sltero L., Zhang P., Lan X.R., Lan H.Y. and Adrogue H.J., Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7, Am J Physiol Renal Physiol. 2007, 293: 1123-1130. |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Angiotensin II Induces
Epithelial-Mesenchymal Transition (EMT) via the TGF-beta/Smad3-Dependent and
ERK/p38 MAP Kinase-Smad3 Crosstalk Pathways: Essential Role of Smad3, 13th
Medical Research Conference of Department of Medicine ( |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Signaling Mechanisms of
Angiotensin II-Induced EMT in Tubular Epithelial Cells, The 12th Research
Postgraduate Symposium, HKU, 12- |
|
Zhang
R., Li M., |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Researcher
: Lan XR |
|
Project Title: |
Regulation of ACE2 expression in hypertension |
|
Investigator(s): |
Lan XR |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2007 |
|
Abstract: |
|
The recent discovery of the Ang II
breakdown enzyme ACE2 and alternative Ang II generating pathways such as
chymase in addition to ACE has increased the complexity of our understanding
of Ang II generation and degradation in hypertension (1, 2). ACE2 is a
breakdown enzyme responsible for the degradation of AngII to Angiotensin 1-7
peptide The later has vasodilatory properties and has its own unique receptor
the Mas Receptor. (2). Emerging evidence shows that ACE2 plays an important
role in negatively regulating hypertension (3). In rat models of
hypertension, renal ACE2 mRNA and protein are decreased, although this could
not be confirmed in human hypertensive nephropathy in a prior study (4, 5).
Further, in rats treated with ACE inhibitors and angiotensin receptor
blockers, an increase in local renal ACE2 activity was noted (6). We have
earlier shown that ACE is upregulated in human diabetic nephropathy
accompanied with hypertension, a condition associated with high AngII levels
(7). In preliminary studies, we also found that upregulation of ACE was
associated with downregulation of ACE |
|
List of Research Outputs |
|
Chung A.C.K., Lan X.R., Zhou L., Heuchel R. and Lan H.Y., Loss of Smad7 Promotes Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 11th Asian Pacific Congress of Nephrology. 2008. |
|
Chung
A.C.K., Lan X.R., Zhou L. and Lan H.Y., Loss of Smad7 Promotes Renal
Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 13th
Medical Research Conference of Department of Medicine ( |
|
Lan X.R., Chung A.C.K., Wang X.J., Lai K.N. and Lan H.Y., Mice Overexpressing Latent TGF-{beta}1 Are Protected against Renal Fibrosis in Obstructive Kidney Disease., American journal of physiology. Renal physiology. 2008, 295: F118-27. |
|
Lan X.R., Chung A.C.K., Zhou L., Li A.G., Wang X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis., 43th Annual Meeting Of Australian New Zealand Society Of Nephrology, Gold Coast, Australia (8-12 Sep, 2007). 2007. |
|
Lan X.R., Chung A.C.K., Zhou L., Wong X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis, Journal Of American Society Of Nephrology. 2008, 19: 233-242. |
|
Lan
X.R., Chung
A.C.K., Zhou L., Wang X.J.
and Lan H.Y., Protective Role Of
Latent Tgf-beta |
|
Lan
X.R., Chung
A.C.K., Zhou L., Wang X.J.
and Lan H.Y., Protective role of
latent Transformating Growth Factor-beta |
|
Menke J., Zeller G.C., Kikawada E., Means T.K., Lan X.R., Lan H.Y., Lu B., Farber J., Luster A.D. and Kelley V.R., CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease, J Am Soc Nephrol.. 2008, 19: 1177-89. |
|
Menke J., Lucas J.A., Zeller G.C., |
|
Wang W., Sltero L., Zhang P., Lan X.R., Lan H.Y. and Adrogue H.J., Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7, Am J Physiol Renal Physiol. 2007, 293: 1123-1130. |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Angiotensin II Induces
Epithelial-Mesenchymal Transition (EMT) via the TGF-beta/Smad3-Dependent and
ERK/p38 MAP Kinase-Smad3 Crosstalk Pathways: Essential Role of Smad3, 13th
Medical Research Conference of Department of Medicine ( |
|
Yang
F., Chung A.C.K., Lan X.R. and Lan H.Y., Signaling Mechanisms of
Angiotensin II-Induced EMT in Tubular Epithelial Cells, The 12th Research
Postgraduate Symposium, HKU, 12- |
|
Researcher
: Lau CP |
|
Project Title: |
Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals |
|
Investigator(s): |
Lau CP, Lee KLF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
05/2000 |
|
Abstract: |
|
To demonstrate the non-inferiority of invabradine 7.5mg b.i.d then 10mg b.i.d in improving exercise capacity in comparison to atenolol given by oral route for 4 and a half months to out-patients with chronic stable angina; to determine pharmacokinetic parameters. |
|
Project Title: |
Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction |
|
Investigator(s): |
Lau CP, Yu CM, Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2000 |
|
Abstract: |
|
To investigate the pathogenic role and mechanism of macrophage migration inhibitory factor (MIF) after myocardial infarction (AMI). |
|
List of Research Outputs |
|
Au K.W., Siu D.C.W., Lau C.P., Tse H.F. and Li R.A., Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions, American Journal of Physiology Cellular Physiology . 2007, 294(1): C136-144. |
|
Chan
S.S.C., Leung Y.P., Lau C.P., Wong V. and Lam T.H., A randomized controlled trial
on a smoking cessation intervention among cardiac outpatients: Stage of
readiness to quit smoking over time, 8th |
|
Chan
S.S.C., Leung Y.P., Lau C.P., Wong V. and Lam T.H., Evaluating the effectiveness of
a stage-specific smoking cessation intervention for cardiac outpatients: A
randomized controlled trial, 8th |
|
Chan S.S.C., Leung Y.P., Lau C.P., Wong V. and Lam T.H., Relationship between previous quit attempts and psychology in quitting among Chinese smoking cardiac patients in Hong Kong, Society for Research on Nicotine and Tobacco 14th Annual Meeting, February 27 to March 1, 2008, Portland, Oregon, USA. 2008, 6. |
|
Chan W.C.W., Zhang J.C.L., Dung W.F., Wong Q., Parmacek M...S., Lau C.P. and Cheah K.S.E., Functional analysis of SM22β by targeted gene deletion in mice. , ACGA-HKSMG International Conference on Genetic and Genomic Medicine, Hong Kong. June 8-11, 2008. . 2008. |
|
Chan
W.C.W., Zhang J.C.L., Dung W.F., Wong Q., Parmacek M...S., Lau C.P. and Cheah K.S.E., Functional analysis of
SM22β by targeted gene deletion in mice., ACGA-HKSMG International
Conference on Genetic and Genomic Medicine, |
|
Chen J., Lau C.P. and Li G.R., Characterization of Ca2+ signaling pathways in human cardiac fibroblast, 12th Research postgraduate symposium, HKU.. 2007, 46. |
|
Chen J., Lau C.P. and Li G.R., Characterization of calcium signaling pathways in human cardiac fibroblast., FEBS J/33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 350. |
|
Chen W.H., Cheng X., Lee P.Y., Ng W., Kwok J.Y., Tse H.F. and Lau C.P., Aspirin resistance and adverse clinical events in patients with coronary artery disease., Am J Med. 2007, 120(7): 631-5. |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Lau C.P., Zhang X., Miao L. and Tse H.F., 频率适应性起搏, In: 陈新, 临床心律失常学-电生理和治疗, 北京, 人民卫生出版社, 2007. |
|
Lau C.P., Tse H.F. and Zhang X., 频率适应性起搏, 中华心律失常学杂志, 2007, 10. |
|
Lau G.K.K., Chan Y.H., Yiu K.H., Tam S., Li S.W., Lau C.P. and Tse H.F., Incremental predictive value of vascular assessments with Framingham risk score for prediction of coronary events in low-intermediate risk subjects. , Postgrad Med J (in press) . 2008. |
|
Leung Y.P., Chan S.S.C., Lau C.P., Wong V. and Lam T.H., Confirmatory factor analyses of three versions of the perceived stress scale (PSS) in Chinese smoking cardiac patients, 8th Asia Pacific Conference on Tobacco or Health. 18 October. 2007, pp01-08. |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Li
G.R., Sun H. and Lau C.P., Characterization of ion
channels in human cardiac fibroblasts. , Biophys J / 52nd Annual Meeting
and 16th International Biophysical Congress, |
|
Li G.R. and Lau C.P., Recent advances in the development of selective anti-atrial fibrillation drugs, Touching Briefings. 2007, Asia-Pacific Cardiology: 52-53. |
|
Li
G.R., Jin M.W., Tang Q., Qin
G.W., Wang H.B., Zhang X.H., Tse H.F.
and Lau C.P., The natural
compound acacetin prolongs refractory period and prevents experimental atrial
fibrillation in anesthetized dogs. , Am J Coll Cardiol/ACC.08, |
|
Siu D.C.W., Au K.W., Lau C.P., Tse H.F. and Li R.A., Dynamic Conformational changes of the P-S6 linker of the packemakers (HCN) Channels identified by sulfhydryl modification: Port-to-gate coupling model , Heart Rhythm . 2008, 5, No. 5 May Supplement. |
|
Siu D.C.W., Zhang X., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., Recurrence of Atrial Fibrillation in hyperthyroidism related atrial fibrillation: A matched case-control study., Heart Rhythm Society Scientific Meeting 2008. |
|
Song L., Koo M.W.L., Cheung B.M.Y. and Lau C.P., Effects of green tea on hypercholesterolemia induced hypertension in rats, Southeast Asian Western Pacific Regional Federation of Pharmacologists and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Meeting. 2007. |
|
Tang Q., Jin M.W., Xiang J.Z., Dong M., Sun H., Lau C.P. and Li G.R., The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. , Biochem Pharmacol. 2007, 74(11): 1596-607. |
|
Tang
Q., Jin M.W., Xiang J.Z., Dong M.Q., Lau C.P. and Li G.R., The membrane permeable calcium
shelator BAPTA-AM directly blocks hERG channels stably expressed in HEK 293
cells. , 9th National Symposium of Chinese Cardiovascular Pharmacological
Society. |
|
Tao R., Lau C.P., Lee H.C. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cell proliferation through the modulation of spontaneous Ca2+ oscillations. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 295. |
|
Tao R., Lau C.P. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cells proliferation through modulation of spontaneous Ca2+ oscillation, 13th Medical Research Conference, LKS Faculty of Medicine, HKU. 2008. |
|
Tao R., Lau C.P., Tse H.F. and Li G.R., Functional Ion Channels in Mouse Bone Marrow Mesenchymal Stem Cells. , Am J Physiol Cell Physiol. 2007, 293(5): C1561-7. |
|
Tse H.F., Thambar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohon J., Bastian B., Chan J.K., Lo G., Ho C.L., Parker A., Hauser T.H. and Lau C.P., Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease, American Heart Journal. 2007, 154(5): 982.e1-982.e6. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Tse H.F., Thambsar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohn J., Thomas P., Bastian B., Chan J.K.F., Lo G., Ho C.L., Chan W.S., Kwong R.Y., Parker A., Hauser T., Chan J., Fong Y.T. and Lau C.P., Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases, European Heart Journal. 2007, 28: 2998-3005. |
|
Tse H.F., Kwok K.W., Siu D.C.W., Tang M.O., Ho W.Y. and Lau C.P., Ventricular Rate regularization with right ventricular septal pacing preserves left ventricular function and improves exercise capacity in patients with permanent atrial fibrillation , Heart Rhythm . 2008, 5,No. 5 May Supplement. |
|
Wang
M.M., Tse H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in
Inter-atrial Dyssynchrony and Atrial Mechanical Function in Sick Sinus
Syndrome with or without Paroxysmal Atrial Fibrillation (Oral presentation), The
American Heart Assosiation Scientific Sessions |
|
Wang M.M., Lau C.P., Siu D.C.W., Lee K.L.F. and Tse H.F., Differential in inter-atrial dyssynchrony and atrial mechanical function in sick sinus syndrome with or without paroxysmal atrial fibrillation., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang M.M., Tse H.F., Siu D.C.W., Lee K.L.F. and Lau C.P., Improvement of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang
M.M., Siu D.C.W., Zhang X., Lau C.P. and Tse H.F., Is atrial dyssynchrony
important in sinus node disease with or without atrial fibrillation?, The
American Society of Echocardiography, |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
|
Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
|
Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells in patients with type II diabetes. , Mol Nutr Food Res (in press). 2008. |
|
Wu E.X., Wu Y., Nicholls J.M., Liao S., Lau C.P. and Tse H.F., MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model, In: Wu EX, Magn Reson Med. . 58(4), 2007, 687-95. |
|
Wu
W., Lau C.P., Tse T.F. and Li G.R., Epidermal growth factor
receptor kinase and human ether a-go-go gene potassium channels. , 3rd
International Symposium on health aging. The |
|
Yiu K.H., Lau G.K.K., Lau C.P. and Tse H.F., A review of surrogate markers for atherosclerosis: flow mediated dilatation, carotid intima media thickness, pulse wave velocity and ankle brachial index. , Vasc Disease Prevention (in press). 2008. |
|
Zhan H., Tse H.F., |
|
Zhang
D., Lau C.P. and Li G.R., Regulation of hERG potassium
channel by EGFR and scr-related Tyrosiner kinases. , 9th National
Symposium of Chinese Cardiovascular Pharmacological Society. |
|
Zhang D., Lau C.P. and Li G.R., Regulation of human ether-a-go-go-related gene potassium channels by EGFR kinase and Src-related tyrosine. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 323. |
|
Zhang X., Chen H., Siu D.C.W., Yiu K.H., Chan W.S., Lee K.L., Chan H.W., Lee S.W., Fu G.S., Lau C.P. and Tse H.F., New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function., Journal of Cardiovascular Electrophysiology. 2008, 19(2): 136-141. |
|
de Voogt W., van Hemel N., de Vusser P., Mairesse G.H., van Mechelen R., Koistinen J., van den B.O.S. .A., Roose I., Voitk J., Yli-Maryry S., Stockman D., EI Allaf D., Tse H.F. and Lau C.P., No evidence of automatic atrial overdrive pacing efficacy on reduction of paroxysmal atrial fibrillation, Europace . 2007, 9(9): 798-804. |
|
Researcher
: Lau G |
|
Project Title: |
Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy |
|
Investigator(s): |
Lau G, Liang RHS, He ML |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection. |
|
Project Title: |
Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection |
|
Investigator(s): |
Lau G, Lin CL, Zhang H |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon. |
|
Project Title: |
Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese |
|
Investigator(s): |
Lau G |
|
Department: |
Medicine |
|
Source(s) of Funding: |
|
|
Start Date: |
02/2005 |
|
Abstract: |
|
To define teh prevalence of non-alcoholic fatty liver diseases (NAFLD) in Hong Kong Chinese; to charaterize the natural history of NAFLD in patients with and without chronic HBV infection. |
|
Project Title: |
Role of upregulation of toll-like receptor 7 and functional polymorphisms within the toll-like receptor 7 gene in inducing sustained disease remission in chronic hepatitis B infection |
|
Investigator(s): |
Lau G, Hui CK, Luk JMC, Sham PC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2006 |
|
Abstract: |
|
To determine if upregulation of toll-like receptor 7 (TLR7) by interferon-based therapy will lead to activation of HBV specific T cell response via cytokine mediated pathway; to study the genetic variations in the TLR7 gene in Chinese chronic hepatitis B patients which are indicative of the serological clearance of hepatitis B surface antigen (HBsAg) after treatment with pegylated interferon-α. |
|
List of Research Outputs |
|
Chen Y., Lin M.C., Yao H., Wang H., Zhang A.Q., Yu J., Hui C.K., Lau G., He M.L., Sung J. and Kung H.F., Lentivirus-mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-regulation of Stathmin (Erratum in: Hepatology. 2007 Oct;46(4):1314), Hepatology. 2007, 46(1): 200-208. |
|
Chen Y., Zhang H., Lu L. and Lau G., Role of Regulatory T cells in Natural Immunity and Sustained Pharmacological Control of Chronic HBV, 2007 Liver Meeting/American Association for the Study of Liver Diseases. 2008. |
|
Chen Y.X., Man K., Ling G.S., Chen Y., Sun B., Cheng Q., Wong O.H., Lo C.K., Ng I.O.L., Chan L.C., Lau G., Lin S.C.L., Huang F. and
Huang F.P., A crucial role for dendritic cell (DC) IL |
|
He Q., Zhu R., Lei T., Ng M.Y.M., Luk J.M.C., Sham P.C., Lau G. and Chiu J., Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma, Journal of Cellular Biochemistry. 2008, 103: 740-752. |
|
Hui C.K., Zhang H., Bowden S., Locarnini S., Luk J.M.C., Leung K.W., Yueng Y.H., Wong A., Rousseau F., Yuen K.Y., Naoumov N.N. and Lau G., 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B, Journal of Hepatology. 2008, 48(5): 714-720. |
|
Hui C.K., Leung N., Shek T.W.H., Zhang H., Luk J.M.C., Poon R.T.P., Lo C.M., Fan S.T. and Lau G., Changes in liver histology as a surrogate endpoint of antiviral therapy for chronic HBV can predict progression to liver complications, Journal of Clinical Gastroenterology. 2008, 42(5): 533-538. |
|
Hui C.K., Cheung W.W., Leung K.W., Cheng V.C.C., Tang S.F., Li W.S., Lee N.P., Kwong Y.L., Au W.Y., Yuen K.Y., Lau G. and Liang R.H.S., Outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen, Hepatology. EPub, 2008. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Hui C.K., Leung N., Shek T.W.H., Yao H., Lee W.K., Lai J.Y., Lai S.T., Wong W.M., Lai S.L., Poon R.T.P., Lo C.M., Fan S.T. and Lau G., Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients , Hepatology. 2007, 46(3): 690-698. |
|
Lau
G., "Entering a new era for hepatitis
viral load measurement”, |
|
Lau G., Zhang H., Li J., Hui C.K., Yeung Y.H., Wang Y.D. and Yie D.W., IL-17 stimulating HBV leaving from PBMC may help HBV clearance in serum of chronic HBV patients under pegylated interferon., In: Zhang HY, Li J, Hui CK, Yeung YH, Wang YD, Yie DW, Lau GK. , J Hepatol 2008. 48: S219. |
|
Lau G., Illustration of FDA requirements fo new discovery/classical formulation., In: Lau GK., Symposium of Global Development on Chinese Medicine Proceedings 2008. Chapter 18: 61-62. |
|
Lau G., The impact of viral resistance on the natural history of chronic hepatitis B infection., In: Lau GK. , BC)VH viral hepatitis. 2008. |
|
Lau G., 世界肝炎日籲人人做檢查, am730. 2008. |
|
Lau G., 納米銀顆粒抑制乙肝病毒助研發新藥減副作用, am730. 2008. |
|
Lau G., 40萬港人患乙肝不自知(10:51), 明報即時新聞, 2008. |
|
Lau G., 納米銀顆粒抑制乙肝病毒複製, 都市日報, 2008. |
|
Lau G., 納米銀顆粒增負重 打殘乙肝病毒, 太陽報, 2008. |
|
Lau G., 港大納米銀粒治乙肝, 星島日報, 2008. |
|
Lau G., 納米銀顆粒能抑制乙肝病毒, 深圳特區報, 2008. |
|
Lau G., 「納米銀顆粒」可遏乙肝病毒 港大首發現 阻複製減襲細胞速度, 香港經濟日報, 2008. |
|
Lau G., 納米銀兵醫乙肝, 明報, 2008. |
|
Lau G., 年輕乙肝帶菌者數量驚人, 東方日報, 2008. |
|
Lau G., 注射疫苗乙肝帶菌者未減, 太陽報, 2008. |
|
Lau G., 港大研治療肝病新發現 納米銀顆粒抑乙肝病毒, 大公報, 2008. |
|
Lau G., 40萬港人不知已染乙肝, 蘋果日報, 2008. |
|
Lau G., 40萬港人患乙肝不自知, 大公報, 2008. |
|
Lau G., 40萬港人患乙肝不自知, 澳門日報, 2008, C10. |
|
Lau G., 港大研納米抑制乙肝, 香港商報, 2008. |
|
Lau G., 新藥可追殺乙肝病毒10分鐘減四成最快三年後面世, 蘋果日報, 2008. |
|
Lau G., 專家倡全民乙肝檢查, 香港商報, 2008. |
|
Lau G., 60 萬人料帶乙肝七成不知早檢查服藥可癒免變肝癌, 明報, 2008. |
|
Lau G., 納米銀顆粒」助抑乙肝病毒, 新報, 2008. |
|
Lau G., 慢性乙型肝炎可致肝癌, 成報, 2008. |
|
Lau G., 納米銀粒防乙肝抗藥, 東方日報, 2008. |
|
Lau G., 港大新發現 無抗藥性 最快3年臨床應用納米銀粒醫乙肝 1小時殺毒9成, 文匯報, 2008. |
|
Lau G., 港大納米技術治乙肝, 頭條日報, 2008. |
|
Lee
D.C.W., Chik S.C.C., Yang L.H., Li C.B., Rong J., Lau G., Tam P.K.H. and Lau A.S.Y., Application of Microarray
and Gas Chromatography-Mass Spectrometry Technologies to Investigate the
Immunomodulatory Effects of Ginseng on Human Monocytic Cells, The Sixth
Meeting of Consortium for Globalization of Chinese Medicine (CGCM). |
|
Lee P.Y., Leung K.W., Cheung N., Lam B.Y., Xu Z., Sham P.C., Lau G., Poon R.T.P., Fan S.T. and Luk J.M.C., Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma, Proteomics. 2008, 8(10): 2136-2149. |
|
Lu L., Sun R.W., Chen R., Hui C.K., Ho C.M., Luk J.M.C., Lau G. and Che C.M., Silver nanoparticles inhibit hepatitis B virus replication, Antivir. Ther.. 2008, 13(2): 253-262. |
|
Luk J.M.C., Wang X., Liu P., Wong K.F., Chan K.L., Tong Y., Hui C.K., Lau G. and Fan S.T., Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation, Liver International. 2007, 27(7): 879-890. |
|
Sun S., Lee P.Y., Poon R.T.P., Fan S.T., He Q., Lau G. and Luk J.M.C., Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways (Review Article), Liver International. 2007, 27(8): 1021-1038. |
|
Yi X., Luk J.M.C., Lee P.Y., Peng J., Leng X., Guan X.Y., Lau G., Beretta L. and Fan S.T., Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence, Molecular and Cellular Proteomics. 2008, 7(2): 315-325 (corresponding author). |
|
Researcher
: Lau GKK |
|
Project Title: |
Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy |
|
Investigator(s): |
Lau G, Liang RHS, He ML |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection. |
|
Project Title: |
Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection |
|
Investigator(s): |
Lau G, Lin CL, Zhang H |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon. |
|
Project Title: |
Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese |
|
Investigator(s): |
Lau G |
|
Department: |
Medicine |
|
Source(s) of Funding: |
|
|
Start Date: |
02/2005 |
|
Abstract: |
|
To define teh prevalence of non-alcoholic fatty liver diseases (NAFLD) in Hong Kong Chinese; to charaterize the natural history of NAFLD in patients with and without chronic HBV infection. |
|
Project Title: |
Role of upregulation of toll-like receptor 7 and functional polymorphisms within the toll-like receptor 7 gene in inducing sustained disease remission in chronic hepatitis B infection |
|
Investigator(s): |
Lau G, Hui CK, Luk JMC, Sham PC |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2006 |
|
Abstract: |
|
To determine if upregulation of toll-like receptor 7 (TLR7) by interferon-based therapy will lead to activation of HBV specific T cell response via cytokine mediated pathway; to study the genetic variations in the TLR7 gene in Chinese chronic hepatitis B patients which are indicative of the serological clearance of hepatitis B surface antigen (HBsAg) after treatment with pegylated interferon-α. |
|
List of Research Outputs |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Lau G.K.K., Chan Y.H., Yiu
K.H., Tam S., Li S.W., Lau C.P. and Tse H.F., Incremental predictive value
of vascular assessments with |
|
Yiu K.H., Lau G.K.K., Lau C.P. and Tse H.F., A review of surrogate markers for atherosclerosis: flow mediated dilatation, carotid intima media thickness, pulse wave velocity and ankle brachial index. , Vasc Disease Prevention (in press). 2008. |
|
Researcher
: Lau GKK |
|
List of Research Outputs |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Lau G.K.K., Chan Y.H., Yiu
K.H., Tam S., Li S.W., Lau C.P. and Tse H.F., Incremental predictive value
of vascular assessments with |
|
Yiu K.H., Lau G.K.K., Lau C.P. and Tse H.F., A review of surrogate markers for atherosclerosis: flow mediated dilatation, carotid intima media thickness, pulse wave velocity and ankle brachial index. , Vasc Disease Prevention (in press). 2008. |
|
List of Research Outputs |
|
Chan B.Y.Y., Lau K.S., Jiang B., Kennelly E.J., Kronenberg F. and Kung A.W.C., Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells, BONE. 2008. |
|
Researcher
: Lau TYI |
|
List of Research Outputs |
|
Lau T.Y.I., Ye H.Y., Xu A. and Lam K.S.L., Macrophage-adipocyte
cross-talk in the initiation of obesity-related insulin resistance and type
2diabetes. , 43rd Annual Meeting of the EASD, 17-21 September 2007, |
|
Researcher
: Lau WCS |
|
Project Title: |
Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong |
|
Investigator(s): |
Lau WCS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1993 |
|
Abstract: |
|
To study the clinical pattern of systemic
lupus erythematosus in |
|
Project Title: |
Effects of sex hormones on lymphocyte function in systemic lupus erythematosus |
|
Investigator(s): |
Lau WCS, Mok TMY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To examine the effects of estrogen, testrogen, testosterone and prolactin on SLE peripheral T- and B-lymphocyte apoptosis and function. Menstruating and postmenopausal female patients and male patients will be studied. |
|
Project Title: |
A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome |
|
Investigator(s): |
Lau WCS, Chan EYT, Cheung BMY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To investigate the time course of changes in cytokines in patients with SARS; to investigate the relationship between clinical deterioration and changes in the serum/plasma levels of cytokines; to evaluate the cytokine expression in post-mortem lung tissues of patients with SARS will be studied. |
|
Project Title: |
Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus |
|
Investigator(s): |
Lau WCS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To study the effects of oestrogen and progesterone on the rate of apoptosis and secondary necrosis of PMN and M[phi] in SLE patients and controls; to study the effects of oestrogen and progesterone on the ability of phagocytic M[phi] to clear apoptotic bodies in patients with SLE and controls. |
|
Project Title: |
Complement deficiency and dendritic cell function in the pathogenesis of systemic lupus erythematosus |
|
Investigator(s): |
Lau WCS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To determine their phenotypic expression i.e. stage of maturity; to study their functional activity through intracellular cytokine detection; to study their capability to phagocytose apoptotic cells and their subsequent functional changes; to evaluate the effects of various complement factors including C1q, C2, C3, C4 and mannose binding lectin on their uptake of apoptotic cells; to determine their interactions with T-cells following ingestion of apoptotic cells and to delineate the subsequent changes in T-cell activity through intracellular cytokine detection. |
|
Project Title: |
Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus |
|
Investigator(s): |
Lau WCS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Disturbances in the process of apoptosis
and the clearance of apoptotic cells, a major source of auto-antigens, have
been suggested as the fundamental pathoaetiological mechanism of systemic
lupus erythematosus (SLE) which is characterised by T and B cell activation.
Excess apoptotic cells may be captured by dendritic cells (DCs) which may
then undergo functional changes and influence the activity of other immune
cells, particularly T cells. Previous studies on DCs in SLE have yielded
conflicting results with some demonstrating a deficiency in DC function,
particularly CD |
|
List of Research Outputs |
|
Ho Y.W., Yeung J.S.L., Chiu P.K.Y., Tang W.M., Lin Z.B., Man R.Y.K. and Lau W.C.S., Ganoderma lucidum polysaccharide peptide reduced the production of pro-inflammatory cytokines in activated rheumatoid synovial fibroblast, Molecular & Cellular Biochemistry. 2007, 301(1-2): 173-179. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Mok
T.M.Y., Fung P.C.W., Ooi C., Tse H.F., Wong Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
|
Sun L.Y., Zhou K.X., Feng X.B., Zhang
H.Y., Ding X.Q., Jin O., Lu L., Lau W.C.S., Hou Y.Y. and Fan L.M.,
Abnormal Surface Markers Expression on Bone Marrow CD34+ cells and
Correlation with Disease Activity in Patients with Systemic Lupus
Erythematosus, Clinical Rheumatology. |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Mak C.M., Kwong Y.L., Lam C.W., Chan S.C., Lo C.M., Fan S.T., Chang P.C.M., Lau Y.K., Lok Sun U. and Tam S., Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese, Amyloid. 2007, 14(4): 293-297. |
|
Ng
F.H., Wong S.Y., Lam K.F., Chang P.C.M., Lau Y.K., |
|
Ng
F.H., Lam K.F., Wong S.Y., Chang P.C.M., Lau Y.K., Yuen W.C., |
|
Researcher
: Lee KK |
|
List of Research Outputs |
|
Kung A.W.C. and Lee K.K., Effect of anti-resorptive agents on fracture rates in subjects selected for therapy on the basis of clinical risk factors or low bone mineral density, American Society for Bone and Mineral Research 29th Annual Meeting, Hawaii, USA. 2007. |
|
Kung A.W.C. and Lee K.K., Effect of bisphosphonates on bone mineral density in subjects with normocalcaemic primary hyperparathyroidism, 29th Annual Meeting of the American Society for Bone and Mineral Research, Hawaii, USA. 2007. |
|
Researcher
: Lee KLF |
|
List of Research Outputs |
|
Wang
M.M., Tse H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in Inter-atrial
Dyssynchrony and Atrial Mechanical Function in Sick Sinus Syndrome with or
without Paroxysmal Atrial Fibrillation (Oral presentation), The American
Heart Assosiation Scientific Sessions |
|
Wang M.M., Lau C.P., Siu D.C.W., Lee K.L.F. and Tse H.F., Differential in inter-atrial dyssynchrony and atrial mechanical function in sick sinus syndrome with or without paroxysmal atrial fibrillation., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang M.M., Tse H.F., Siu D.C.W., Lee K.L.F. and Lau C.P., Improvement of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
|
Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
|
Researcher
: Lee SWL |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Researcher
: Leung AYH |
|
Project Title: |
A study of normal and deregulated haematopoiesis in zebrafish, with special reference to the role of BMP signaling in haematopoietic stem cell proliferation |
|
Investigator(s): |
Leung AYH, Liang RHS, Kung H |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
07/2004 |
|
Abstract: |
|
To characterize the cellular features of expanded haematopoietic cells, i.e. do they contain HSC or lineage-committed progenitors or do they contain both? to understand the key signal(s) that drive(s) haematopoietic cell proliferation in the developing embryos in relation to a heightened BMP signaling due to reduced antagonism by chordin. |
|
Project Title: |
The roles of survivin in hematopoiesis, angiogenesis and tumorigenesis in a zebrafish knock-down and transgenic model |
|
Investigator(s): |
Leung AYH, Wong BCY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
07/2006 |
|
Abstract: |
|
(1) To study the role of survivin in primitive hematopoiesis and angiogenesis (i) Effects of survivin knock-down on hematopoiesis and angiogenesis (ii) Mechanism of action with reference to anti-apoptotic function (iii) To prove the specificity of survivin knock-down phenotype (iv) To distinguish cell autonomous (or non cell autonomous) function of survivin (2) To over-express survivin in hematopoietic cells to investigate the anti-apoptotic and leukemic potential of survivin over-expression (i) Transient expression of survivin in zebrafish embryos (ii) Generation of stable transgenic fish-line over-expressing survivin |
|
Project Title: |
Establish a blood cancer model of polycythemia vera in zebrafish to facilitate drug screening targeting at Jak2 activation |
|
Investigator(s): |
Leung AYH, Liang RHS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
|
Start Date: |
11/2006 |
|
Abstract: |
|
Human polycythemia vera and Janus Kinase
2 (Jak2) In human polycythemia vera (PV), a clonal disorder arising from
hematopoietic stem cells in the bone marrow, there is abnormal increase in
red cell production, resulting in thrombosis and bleeding which are common
causes of morbidity and mortality in this group of patients. Recent studies
showed that more than 90% patients with PV carry a gain-of-function mutation
at the JH2 pseudokinase domain of the Janus kinase 2 gene (Jak2) in which
valine is substituted with phenylalanine (V |
|
Project Title: |
The roles of Jak |
|
Investigator(s): |
Leung AYH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2007 |
|
Abstract: |
|
1. Background: a. The Janus kinase 2
(Jak2) The Janus kinase/signal transducers and activation of transcription
(JAK/STAT) cascade is a ubiquitous signal transduction in responses to
extracellular ligands. The Jak family consists of four members in mammals
(Jak1-3, Tyk2). In particular, Jak2 has been shown to transduce signals of
various hematopoietic cytokines, including erythropoietin, thrombopoietin,
granulocyte/macrophage colony-stimulating-factor and interleukin-3. b.
Embryonic hematopoiesis occurs in distinct waves – primitive and definitive
During embryonic development, hematopoiesis occurs in two successive waves
known as primitive and definitive hematopoiesis. The former is primarily
erythroid in lineage and is transitory whereas the latter is multi-lineages
and persists throughout life. In mammals, primitive hematopoiesis occurs in
the extra-embryonic yolk-sac. Definitive hematopoiesis is initiated in the
aorto-gonado-mesonephros followed by fetal liver and spleen and eventually
the bone marrow (BM). In zebrafish, primitive hematopoiesis occurs in an
intra-embryonic structure known as the intermediate cell mass (ICM) whereas
definitive hematopoiesis arises from the ventral wall of dorsal aorta and
thence the kidney in which it continues throughout life. c. The role of Jak |
|
List of Research Outputs |
|
Au W.Y., Leung A.Y.H., Tse E.W.C., Cheung W.W., Shek T.W.H. and Kwong Y.L., High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients, Leukemia Research. 2007, 32(4): 547-551. |
|
Chan C.F., Leung A.Y.H., Chan Y.S. and Cheung R.T.F., Central administration of granulocyte- colony stimulating factor in a mice middle cerebral artery occlusion stroke model reduces infarct volume and improves functional outcome, Soc. Neuroscience Abstract (U.S.A.): 598.1. 2007. |
|
Leung
A.Y.H., Zebrafish model of human blood
cancers, 14th |
|
Leung A.Y.H., Zebrafish model of human leukemia, Stem cell in Leukemia and Lymphoma, Biology, Animal Models and Future Directions, Croucher Foundation Conference. 2008. |
|
Ma
C.H., Ward A.C., Liang R.H.S. and
Leung A.Y.H., The role of jak |
|
Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
|
Researcher
: Leung JCK |
|
Project Title: |
Peritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF) |
|
Investigator(s): |
Leung JCK, Li FK, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To examine the pathophysiological effects of PDFs and their components on peritoneal cells; to understand the mechanism of CTGF expression and its regulation in peritoneal cells; to explore the feasibility of treating peritoneal membrane dysfunction by blocking CTGF. |
|
Project Title: |
Is there a
reno-protective role of bone morphogenetic protein |
|
Investigator(s): |
Leung JCK, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To examine the renal expression and
regulation of BMP-7 and its receptors in human IgAN; to explore the mechanism
of BMP |
|
Project Title: |
The role of leptin on peritoneal mesothelial cell under high glucose |
|
Investigator(s): |
Leung JCK, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
Continuous ambulatory peritoneal dialysis
(CAPD) is an important treatment modality of the renal replacement therapy.
Unfortunately, the peritoneal membrane frequently exhibits structural and
functional changes following long-term dialysis [1]. During CAPD, peritoneal
cells are repeatedly exposed to a non-physiological hypertonic environment
that may lead to peritoneal fibrosis and, ultimately, ultrafiltration failure
[2].Peritoneal adipocytes, previously regarded as of less importance in
peritoneal physiology during CAPD, are ubiquitously found in peritoneal
tissues. Contrary to the prevailing view that adipose tissues merely function
as energy storage depot, there is now compelling evidence suggesting
adipocytes can mediate various physiologic processes through secretion of an
array of adipokines including leptin, adiponectin, resistin, tumour necrosis
factor-alpha (TNF-alpha), interleukin (IL)-6, transforming growth factor-beta
(TGF-beta), tissue factors and other growth factors [3, 4]. Adipocytes also
express receptors for leptin, insulin growth factor-1 (IGF-1), TNF-alpha,
IL-6, TGF-beta that orchestrate a network of autocrine, paracrine and
endocrine signals [4]. In parietal peritoneum, adipocytes lie deep underneath
the mesothelium and connective tissue. During the fluid dwell in CAPD,
solutes in peritoneal dialysis fluid (PDF) are transported by passive
diffusion through the peritoneal barrier and come into contact with the
adipocytes. In the omentum, adipocytes are in close contact with mesothelial
cells. Ultrastructural study reveals that a portion of adipocytes are
protruded from the mesothelial surface suggesting that omental adipocytes may
be directly exposed to dialysate [5]. In addition, dialysate can also reach
the parietal adipose tissue when there is junctional damage or denudation of
the mesothelial monolayer. It is therefore logical to postulate that under
repeated exposure to PDF and the continuous changes of the physiologic milieu
of the peritoneal cavity during CAPD, peritoneal adipocytes will inevitably
be "activated". Yet, study on any impact of CAPD on peritoneal
adipocytes is scarce.Leptin, an adipocytes-derived 16-kDa hormone, exerts
many biological effects through leptin receptor including regulation of food
intake, modification of insulin action, induction of angiogenesis and
modulation of the immune system [4, 6]. Leptin receptors belong to the class
I cytokine family with six spliced isoforms (Ob-Ra to Ob-Rf) [4]. Only the
full-length isoform, Ob-Rb, contains the intracellular motifs essential for
the Janus kinase-signal transducers and activation (JAK-STAT) signal
transduction pathway [4, 7]. Accumulating evidence for systemic effects of
leptin on specific tissues and metabolic pathways indicates that leptin
operates both directly and indirectly to orchestrate complex
pathophysiological processes [6, 8]. Leptin is cleared principally by the
kidney and the serum leptin concentration is increased in patients with
chronic renal failure or undergoing dialysis [9]. Marked increase in leptin
concentration in serum as well as spent peritoneal dialysate has been
reported following CAPD treatment [10]. It is now clear that leptin in
peritoneal dialysate is derived not only from plasma but also locally from
peritoneal adipose tissue. In vitro experiments using murine adipocyte cell
line 3T3-L1 showed glucose-based PDFs induce a higher leptin secretion [11].
The present proposal was designed to determine whether functional leptin
receptor is expressed by human peritoneal mesothelial cells (HPMC) and if so,
the possible implication in CAPD. We set out to determine whether functional
leptin receptors are expressed by HPMC and if so, whether these mesothelial
leptin receptors could be triggered by leptin to modulate local TGF-beta
production.We hypothesize that:a) Exposure of the peritoneum to PDF and its
components will increase leptin synthesis by peritoneal adipocytes.b) Leptin,
once released from adipocytes, will act on specific leptin receptors on
mesothelial cells or adipocytes and trigger TGF-beta production by means of a
specific signal transduction pathway.Specific aims:(i) To examine the
pathophysiological effects of glucose on leptin synthesis by peritoneal
adipocytes.(ii) To understand the mechanism of leptin regulation and its
signaling pathways in peritoneal adipocytes under high glucose.References1.
Di Paolo N, Sacchi G, De Mia M, Gaggiotti E, Capotondo L, Rossi P, Bernini M,
Pucci AM, Ibba L, Sabatelli P, et al.: Morphology of the peritoneal membrane
during continuous ambulatory peritoneal dialysis. Nephron 44:204-211, 19862.
Rubin J, |
|
List of Research Outputs |
|
Chan B.C.L., Ching A.K.K., To K.F., Leung J.C.K., Chen S., Li Q., Lai P.B.S., Tang N.L.S., Shaw P.C., Chan J.Y.H., James A.E., Lai K.N., Lim P.L., Lee K.K.H. and Chui Y.L., BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma, Oncogene. 2007, 27: 1208-17. |
|
Chan L.Y., Leung J.C.K., Zhang C., Tang S.C.W. and Lai K.N., Angiotensin II type 2
receptor-mediated ERK inhibition protects tubular epithelial cells from
pro-inflammatory damage, Journal of American Society of Nephrology.
2007, 18: |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Chan W.L., Leung J.C.K., Chan L.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects polymeric IgA
induced mesangial cells injury in IgAN: roles of smad6 and PPAR-gamma, Journal
of American Society of Nephrology. 2007, 18: |
|
Cheung S.C., Guo H., Leung J.C.K., Man K., Lai K.N. and Wu E.X., MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement, Magnetic Resonance in Medicine. 2008, 59: 1170-4. |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Lai K.N., Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Lai F.M. and Tang S.C.W., Activation of podocytes by mesangial-derived TNF-{alpha}: glomerulo-podocytic communication in IgA nephropathy, American Journal of Physiology Renal Physiology. 2008, 294: F945-F955. |
|
Leung
J.C.K., Tang
S.C.W., Chan L.Y., Lam M.F. and Lai
K.N., CTGF regulation amongst peritoneal cells under the context of CAPD,
Journal of American Society of Nephrology. 2007, 18: |
|
Leung J.C.K., Chan L.Y., Tang S.C.W., Tam P.C., Fenn J. and Lai K.N., Glycosylation profile of differently charged IgA1 and their binding characteristics to cultured mesangial cells in IgA nephropathy, Nephron Experimental Nephrology . 2007, 107: 107-118. |
|
Leung
J.C.K., Tang
S.C.W., Lam M.F., Chan Y.Y. and Lai K.N., Serum and spent peritonitis
fluid concentration of neutrophil gelatinase-associated lipocalin (NGAL) in
peritonitis, Peritoneal Dialysis International. |
|
Leung J.C.K., Tang S.C.W., Chan Y.Y., Chan W.L. and Lai K.N., Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA-role of MAPK and NFkB, Nephrology Dialysis Transplantation. 2008, 23: 72-81. |
|
Tang S.C.W., Leung J.C.K., Chan L.Y., Eddy A.A. and Lai K.N., ACEi suppresses angiotensin II-induced MAPK activation and TGF-β secretion in cultured PTEC, Proceedings of The World Congress of Nephrology. 2007, 368. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Eddy A.A. and Lai K.N., Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy, Kidney International. 2008, 73: 288-299. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Tang
S.C.W., Leung J.C.K., Chan
L.Y., Yuen Y.M. and Lai K.N.,
PPAR-gamma agonist reduces intrarenal injury and inflammation in genetically
diabetic db/db mice with accelerated glomerular and tubulo-interstitial
lesions, Journal of American Society of Nephrology. 2007, 18: |
|
Researcher
: Leung KW |
|
List of Research Outputs |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Researcher
: Leung TWT |
|
List of Research Outputs |
|
Epstein R. and Leung T.W.T., Tumor resensitization to erlotinib following brief substitution of cetuximab., Cancer Chemother Pharmacol. 2008. |
|
Researcher
: Leung YH |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
|
Chu L.W., Li Y., Tang A.Y.B., Cheung B.M.Y., Leung Y.H., Yik P.Y., Jin D. and Song Y., A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer' s disease in Chinese, Am J Med Genet B. 2007, 144(8): 1007-13. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
|
Researcher
: Leung YH |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
|
Chu L.W., Li Y., Tang A.Y.B., Cheung B.M.Y., Leung Y.H., Yik P.Y., Jin D. and Song Y., A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer' s disease in Chinese, Am J Med Genet B. 2007, 144(8): 1007-13. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
|
Researcher
: Li DKT |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Researcher
: Li G |
|
Project Title: |
The
Neuroprotective Effect of Coenzyme Q |
|
Investigator(s): |
Li G, Yang ES, Jack Jr CR |
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
Alzheimer's disease (AD) and ischemic
cerebrovascular disease are two main causes of dementia in elderly people.
Recent basic and clinical investigations demonstrate that AD and vascular
dementia (VaD), traditionally considered two independent neurological
disorders, may interact in an additive manner. In clinical studies, the presence
of ischemic lesions enhances the cognitive deficits in patients with AD
pathology. Mutations in the genes of beta-amyloid precursor protein (APP),
presenilin 1 (PS1) and presenilin 2 (PS2) cause familial AD. In transgenic
mice with overexpressed APP, susceptibility to ischemic brain damage caused
by middle cerebral artery occlusion (MCAO) is increased. In AD patients, the
extent of AD pathology is increased if ischemic stroke coexists. Elderly
subjects are more likely to have been demented in life if both AD pathology
and ischemic cerebrovascular disease are present at autopsy than if either is
pathology is found in isolation. Several studies suggest a possible role of
increased oxidative stress and impairment of mitochondrial energy metabolism
in the pathogenesis of both AD and stroke. A number of investigators have
identified a deficiency in the complex VI, cytochrome c oxidase (COX) of the
mitochondrial electron transport chain in AD patients and a reduced activity
of complexes I and III in ischemic conditions. Coenzyme Q10 (CoQ10) is an
essential biological cofactor produced endogenously in the body and provided
in the food chain. As the electron acceptor for mitochondrial complexes I and
II, it has an essential role in cellular energy production as an electron and
proton carrier. Complex I or II dysfunction are found in neurological
disorders such as Parkinson’s disease and Huntington disease. Shults et al.
reported a correlation between mitochondrial CoQ10 level and the biological
activity of complexes I - IV Parkinson’s disease patients who were
administered the highest dose of CoQ10 showed the greatest clinical benefit.
Oral CoQ10 supplementation increases brain mitochondrial concentrations and
exerts neuroprotective effects. A neuroprotective effect of CoQ10 has been
found in various animal models of stroke and this has been attributed to its
role as a potent antioxidant and an oxygen derived free radical scavenger.
This finding has not been universally replicated, however, as Li and his
colleagues found that immediate treatment with CoQ10 via intraperitoneal
injection did not prevent neuronal injuries following global and focal
ischemia. Mitochondrial abnormalities have been found in human AD patients,
and there are a few reports about the therapeutic effect of CoQ |
|
Project Title: |
Effect of imbalance of kinases and protein phosphatases on deposit of B amyloid and Tau Pathology in double transgenic APP/PS1 Mice |
|
Investigator(s): |
Li G, Yang X, Yang ES |
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Germany/Hong Kong Joint Research Scheme |
|
Start Date: |
01/2007 |
|
Abstract: |
|
1. To investigate the effect of the
overactivation of GSK-3 on deposit of amyloid and tau pathology in APP/PS1
double transgenic mice 2. To investigate the effect of the suppression of the
two major proteins - phosphatase |
|
List of Research Outputs |
|
Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
|
Zheng Y., Chan C.C., Li G., Lam E.Y.M. and Yang E.S., A study of femoral artery by twin drivers in Magnetic Resonance Interference Elastography, 29th International Conference of the IEEE Engineering in Medicine and Biology Society. 2007. |
|
Zheng Y., Li G., Chen M., Hu S., Zhao X., Ehman L., Lam E.Y.M. and Yang E.S., Magnetic Resonance Elastography with twin pneumatic drivers for wave compensation, 29th International Conference of the IEEE Engineering in Medicine and Biology Society. 2007. |
|
Researcher
: Li G |
|
List of Research Outputs |
|
Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
|
Zheng Y., Chan C.C., Li G., Lam E.Y.M. and Yang E.S., A study of femoral artery by twin drivers in Magnetic Resonance Interference Elastography, 29th International Conference of the IEEE Engineering in Medicine and Biology Society. 2007. |
|
Zheng Y., Li G., Chen M., Hu S., Zhao X., Ehman L., Lam E.Y.M. and Yang E.S., Magnetic Resonance Elastography with twin pneumatic drivers for wave compensation, 29th International Conference of the IEEE Engineering in Medicine and Biology Society. 2007. |
|
Researcher
: Li GR |
|
Project Title: |
Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
|
Investigator(s): |
Li GR, Lau CP, Chiu SW, Tse HF |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2001 |
|
Abstract: |
|
To determine the intracellular signaling pathways that regulate ICl.vol and cell volume in human atrium; to determine whether ICl.vol is persistently activated in atrial myocytes from patients with dilated atrial cardiomyopathy. |
|
Project Title: |
Studies on Ion Channels in Human Pre-adipocytes |
|
Investigator(s): |
Li GR, Lau CP |
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2006 |
|
Abstract: |
|
Ion channels play an important role in the physiological activities of many types of cells. In excitable cells, activation of ion channels generates action potentials and participates in excitation-contraction (muscles), excitation-secretion (glands), and impulse conduction (nerve and muscles), as well as repolarizing cell membrane potential. In proliferative cells, ion channels are found to be required for cell proliferation. Recent studies have demonstrated that several K channels, eg. inward rectifier K channels (IKir), delayed rectifier K channels (IKDR), ATP-sensitive K channel (IKATP), are involved in the cell cycling of lymphocytes, neuronal glial cells (e.g. astrocytes), epithelial cells, and cancer cells. Blockade of IKDR is believed to inhibit cell proliferation, whereas inhibition of IKIR promotes proliferation in rat spinal cord astrocytes. In addition, volume-sensitive chloride current (ICl.vol) is involved in the proliferation of several types of cells including vascular smooth muscle and endothelial cells, cancer cells etc. These studies indicate an important relationship between ion channels and cell proliferation. There has been a dramatic increase in the incidence of obesity resulting from an excess of white adipose tissue. Obesity is a prevalent health hazard in industrial countries, and is closely associated with the occurrence of type 2 diabetes and cardiovascular disease. Preadipocytes are the origin of fat cells of white adipose tissue. For the past two decades, in vitro systems have been extensively used to study adipocyte differentiation with preadipocytes. Although significant progress has been made in the dissection of the molecular and cellular events taking place during the transition from undifferentiated preadipocytes into mature round fat cells, control of adipocyte differentiation is not completely understood, especially ion channels and thire physiological roles in proliferation/differentiation have not been studied. The present proposal was to study ion channel expression and thire molecular identidies in human pre-adipocytes commercially obtained from CellSicence using whole-cell patch clamp and RT-PCR techniques, and to provide the experimental data for obtaining external RGC grant to further study whether/how ion channels are involved in proliferation/differentiation in human pre-adipocytes. |
|
Project Title: |
Studies on ion channels and cell proliferation in human cardiac fibroblasts |
|
Investigator(s): |
Li GR, Lau CP |
|
Department: |
Medical Faculty |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To analyze the molecular identities of IKCa, IKDR, ICI.vol, and INa, in human cardiac fibroblasts with RT-PCR, Western blot analysis, and patch clamp technique; to test the hypothesis that these four types of channels (IKCa, IKDR, ICI.vol, and INa are involved in the proliferation of human cardiac fibroblasts. Cell proliferation assays will be conducted in the absence and presence of channel blockers, short interfering RNA (siRNA) oligos targeted to IKDR, IKCa, ICI.vol, and INa and channels, and/or signal modulators. |
|
List of Research Outputs |
|
Chen J., Lau C.P. and Li G.R., Characterization of Ca2+ signaling pathways in human cardiac fibroblast, 12th Research postgraduate symposium, HKU.. 2007, 46. |
|
Chen J., Lau C.P. and Li G.R., Characterization of calcium signaling pathways in human cardiac fibroblast., FEBS J/33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 350. |
|
Deng X., Lau C.P., Lai K.W.H., Cheung K.F., Lau G.K.K. and Li G.R., Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. , Cell Prolif. 2007, 40(5): 656-670. |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Li
G.R., Sun
H. and Lau C.P., Characterization
of ion channels in human cardiac fibroblasts. , Biophys J / 52nd Annual
Meeting and 16th International Biophysical Congress, |
|
Li
G.R., Protein tyrosine kinases and regulation
of cardiac ion channels. , Basic & Clinical Medicine / 6th Scientific
Conference on Cardiovascular Science Across the Strait, Uromuqi, |
|
Li G.R. and Lau C.P., Recent advances in the development of selective anti-atrial fibrillation drugs, Touching Briefings. 2007, Asia-Pacific Cardiology: 52-53. |
|
Li
G.R., Studies on acacetin from the
traditional Chinese medicine Xue Lian Hua: Cardiac ion channel selectivity
and anti-atrial fibrillation. , 9th National Conference on Cardiovascular
Pharmacology. |
|
Li
G.R., Jin M.W., Tang Q., Qin G.W., Wang H.B., Zhang
X.H., Tse H.F. and Lau C.P., The natural compound acacetin
prolongs refractory period and prevents experimental atrial fibrillation in
anesthetized dogs. , Am J Coll Cardiol/ACC.08, |
|
Li
G.R., The natural flavone acacetin from TCM
targets to atrial repolarization currents. , 2nd International
Cardiovascular Target Therapy Forum, |
|
Tang Q., Jin M.W., Xiang J.Z., Dong M., Sun H., Lau C.P. and Li G.R., The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. , Biochem Pharmacol. 2007, 74(11): 1596-607. |
|
Tang
Q., Jin M.W., Xiang J.Z., Dong M.Q., Lau
C.P. and Li G.R., The
membrane permeable calcium shelator BAPTA-AM directly blocks hERG channels
stably expressed in HEK 293 cells. , 9th National Symposium of Chinese
Cardiovascular Pharmacological Society. |
|
Tao R., Lau C.P., Lee H.C. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cell proliferation through the modulation of spontaneous Ca2+ oscillations. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 295. |
|
Tao R., Lau C.P. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cells proliferation through modulation of spontaneous Ca2+ oscillation, 13th Medical Research Conference, LKS Faculty of Medicine, HKU. 2008. |
|
Tao R., Lau C.P., Tse H.F. and Li G.R., Functional Ion Channels in Mouse Bone Marrow Mesenchymal Stem Cells. , Am J Physiol Cell Physiol. 2007, 293(5): C1561-7. |
|
Wu
W., Lau C.P., Tse T.F. and Li G.R., Epidermal growth factor
receptor kinase and human ether a-go-go gene potassium channels. , 3rd
International Symposium on health aging. The |
|
Wu W.K., Li G.R., Wong T.M., Wang J.Y., Yu L. and Cho C.H., Involvement of voltage-gated K(+) and Na (+) channels in gastric epithelial cell migration. , Mol Cell Biochem. 2008, 308(1-2): 219-26. |
|
Zhang
D., Lau C.P. and Li G.R., Regulation of hERG
potassium channel by EGFR and scr-related Tyrosiner kinases. , 9th
National Symposium of Chinese Cardiovascular Pharmacological Society. |
|
Zhang D., Lau C.P. and Li G.R., Regulation of human ether-a-go-go-related gene potassium channels by EGFR kinase and Src-related tyrosine. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 323. |
|
Zhang X., Li G.R. and Bourreau J.P., The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway. , Am J Physiol Heart Circ Physiol. 2007, 293(5): H2888-93. |
|
Researcher
: Li HY |
|
List of Research Outputs |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease gene identification strategy, 57th Annual Meeting of The American Society of Human Genetics. 2007, 80(suppl): T2119. |
|
Huang Q., Li H.Y., Cheung W.M.W., Song Y. and Kung A.W.C., Prediction of osteoporosis candidate genes by computational disease-gene identification strategy, J Hum Genet. 2008, 53: 644-655. |
|
Qiao
L., Li H.Y., Li Z., Zou B. and Wong B.C.Y., Gene expression profile in
colon cancer cells in response to troglitazone: impact of XIAP expression, Digestive
Disease Week, |
|
Researcher
: Li J |
|
List of Research Outputs |
|
Lau G., Zhang H., Li J., Hui C.K., Yeung Y.H., Wang Y.D. and Yie D.W., IL-17 stimulating HBV leaving from PBMC may help HBV clearance in serum of chronic HBV patients under pegylated interferon., In: Zhang HY, Li J, Hui CK, Yeung YH, Wang YD, Yie DW, Lau GK. , J Hepatol 2008. 48: S219. |
|
Researcher
: Li LSW |
|
List of Research Outputs |
|
Lee T.M.C., Li L.S.W. and Chan C.C.H., Functional reorganization of the human brain., Journal of Rehabilitation Medicine. 2008, Suppl. 46: 46. |
|
Leung K.K., Lee T.M.C., Xiao Z.W., Zhang J.X.X., Yip P.S.F. and Li L.S.W., Neural activities for negative priming with affective stimuli: An fMRI study., Neuroscience Letters. 2008, 433: 194-198. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Researcher
: Li RA |
|
List of Research Outputs |
|
Au K.W., Siu D.C.W., Lau C.P., Tse H.F. and Li R.A., Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions, American Journal of Physiology Cellular Physiology . 2007, 294(1): C136-144. |
|
Moore J.C., Fu J., Chan Y.C., Lin D., Tran H., Tse H.F. and Li R.A., Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state, Biochem Biophys Res Commun. . 2008, 372($): 553-8. |
|
Siu D.C.W., Au K.W., Lau C.P., Tse H.F. and Li R.A., Dynamic Conformational changes of the P-S6 linker of the packemakers (HCN) Channels identified by sulfhydryl modification: Port-to-gate coupling model , Heart Rhythm . 2008, 5, No. 5 May Supplement. |
|
Tam
K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Cloning, recombinant
expression and digestion product characterization of chondroitinse ABC I and
II, Seventh IBRO World Congress of Neuroscience, Melbourne, Australia,
July 12-17. |
|
Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Effects of oligosaccharide products on activity of chondroitin sulphate ABC lyase I – Towards improving the efficacy of the enzyme for in vivo treatment, Abstracts of Third International Symposium on Healthy Aging - Improving the Health of an Aging Population: 4. March 1-2. 2008. |
|
Researcher
: Li Z |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Li
Z., Qiao
L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Qiao
L., Li H.Y., Li Z., Zou B. and Wong B.C.Y., Gene expression profile in
colon cancer cells in response to troglitazone: impact of XIAP expression, Digestive
Disease Week, |
|
Researcher
: Liang RHS |
|
Project Title: |
Quantification of circulating Epstein Barr viral DNA in patients with malignant lymphoma: diagnostic and prognostic significance |
|
Investigator(s): |
Liang RHS, Kwong YL, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To define if circulating Epstein-Barr viral (EBV) DNA can be correlated with tumor load in patients with malignant lymphoma; to define the biologic significance and propgnostic value of circulating EBV DNA in malignant lymphoma. |
|
Project Title: |
Molecular determinants of arsenic resistance in APL and prognostic factors of APL in the post arsenic era |
|
Investigator(s): |
Liang RHS, Kwong YL, |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To define the relative significance of FLT-3 mutation and aberrant p15 methylation in prognostication of acute promyelocytic leukaemia (APL) in the era of arsenic salvage; to define the molecular role of molecular transport proteins, protein kinase and tumor suppressor genes in arsenic resistant APL. |
|
Project Title: |
Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine |
|
Investigator(s): |
Liang RHS, Leung AYH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To study whether the use of live-attenuated VZV vaccine in VZV-seropositive donors prior to BMT achieves three objectives: boosts the cellular and humoral immunity of the donors, transfers immunity to patients post BMT, and protects BMT patients from the development of HZ after transplantation. |
|
Project Title: |
Effects of all-trans retinoic acid (ATRA) on stromal cells and haematopoietic stem cell engraftment |
|
Investigator(s): |
Liang RHS, Leung AYH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To focus on AFT024 stromal cells but not primary bone marrow stromal cells; to perform one set of microarray and conform the gene expression profile using RT-PCR for those that show differential expression; to focus on the effects of ATRA on human bone marrow cell engraftment in the NOD/SCID mouse model. |
|
Project Title: |
Roles of survivin in the pathogenesis of multiple myeloma and the therapeutic implication of dominant negative survivin in a murine model of human multiple myeloma |
|
Investigator(s): |
Liang RHS |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Background: Multiple myeloma (MM) is a common blood cancer to which there is no effective cure at present. It is characterized by the presence of abnormal plasma cells which are resistant to apoptotic signals. Angiogenesis in the tumor is also increased. The pathogenesis of MM involves multiple ligand (from microenvironment) and receptors\ (on MM cell surface) interactions, resulting in activation of major signaling pathways, notably the STAT-3, PI3K/Akt and NFkB pathways. These pathways overlap to a considerable extend and targeting any one of them may not impact significantly to the eradication of disease. These have led us to investigate whether a downstream component common to these pathways may provide us with an alternative therapeutic target. In particular, survivin, a member of the inhibitor of apoptotic gene family, is one of the downstream mediators of these pathways and may endow MM cells both with their resistance to apoptosis and increased angiogenesis. Preliminary studies showed that survivin is robustly expressed in both primary MM tissues as well as in a MM cell-line U266. The proposed studies have the following objectives: 1. Investigate the effects of transducing myeloma cells with a dominant negative form of survivin (SurDN) with particular reference to apoptosis and cell-cycle status. Recombinant adeno-associated virus (rAAV) will be used for viral transduction. 2. Establish an in-vivo xenogeneic transplantation model in which eGFP+ MM cells are transplanted into NOD/SCID mice via an intra-femoral route. 3. Investigate the effects of injecting rAAV carrying SurDN on the tumorigenesis of MM cells in this model. Information derived from this project will enable us to address the following issues: 1. Is survivin involved in the pathogenesis of MM, if so, how? 2. Is anti-survivin strategy feasible and efficacious in the treatment of this condition? Results of this project will have important impacts on the following aspects: 1. Explore the therapeutic potential of anti-survivin strategy in the treatment of MM 2. Establish a xenogeneic MM transplantation model that is also important for various therapeutic trials for the treatment of this condition. |
|
Project Title: |
The roles of
aldehyde dehydrogenase |
|
Investigator(s): |
Liang RHS, Leung AYH |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2007 |
|
Abstract: |
|
Objectives of the research proposal: 1.
BACKGROUND a. Concept of Leukemia Initiating Cell (LIC) in Acute Myeloblastic
Leukemia (AML) AML is defined morphologically by an abnormal increase in
myeloblasts in the bone marrow (BM). They are heterogeneous in morphologic
and cytogenetic features as well as prognoses. Recent advances in stem cell
biology have led to an analogous hierarchical model in which a rare
population known as the leukemia initiating cells (LIC) gives rise to
clonogenic leukemic progenitors and leukemia. LIC are derived from
transformation of normal hematopoietic stem cells (HSC) as a result of
cumulated mutations, but share stem cell features of replicative quiescence and
self-renewal potential. The proposition of LIC may explain the late relapses
commonly seen in AML after intensive chemotherapy (which targets at leukemic
blasts but not LIC) and has made it an ideal target for anti-leukemia
therapy. b. Isolation and purification of LIC LIC are characterized by their
ability to recapitulate the leukemic phenotypes in xenogeneic NOD/SCID mouse
transplantation assay. However, the identification of LIC has remained
elusive and was mostly based on strategies adopted for HSC. i. Surface
phenotype may not reliably define LIC. Previous studies have shown that like
HSC, LIC are enriched in the CD34+CD38- fraction of the AML cells. Further
studies have refined the LIC phenotype as CD34+CD38-CD90-CD117-, in contrast
to HSC which are mostly CD34+CD38-CD90+CD117+. However, leukemic cells
bearing these phenotypes are dissimilar functionally only a small fraction of
which contains LIC. Discordant results have been reported in which LIC may be
CD34+CD90+ or even CD34-. Therefore, surface phenotype alone may not reliably
define LIC. ii. Aldehyde dehydrogenase (ALDH) – a conserved functional and
potentially targetable marker of stem cells. This is a family of enzymes
involved in the metabolism of aldehydes to their corresponding carboxylic acids.
In liver, cytosolic ALDH |
|
List of Research Outputs |
|
Au
W.Y., Lam W.M., |
|
Au
W.Y., Lam W.W., |
|
Au
W.Y., Lam W.W., |
|
Au
W.Y., Lam W.W.M., |
|
Au W.Y., Leung R.Y.Y., Mok T., Fung T.K. and Liang R.H.S., Familial occurrence of sequential B-cell lymphoma and myeloproliferative disease , Annals of Hematology. 2008, Epub. |
|
Au
W.Y. and Liang R.H.S.,
Thalassaemia management in |
|
Chan K.K., Shen L., Guo T., Wong M.L.Y., Wong K.Y., Au W.Y., Lu L., Kwong Y.L., Liang R.H.S. and Srivastava G., IL2 induced NF-kB activation in nasal NK/T-cell lymphoma is mediated through Akt and BCL10, Keystone Symposia on Molecular and Cellular Biology: Lymphocyte Activation and Signaling, February 3-8, 2008, Snowbird Resort, Snowbird, Utah. 2008. |
|
Chim J.C.S., Pang R.W.C., Fung T.K., Choi C.L. and Liang R.H.S., Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma, Leukemia. 2007, 21: 2527–2536. |
|
Fung
K.L., Li J., Liang R.H.S. and Chan G.C.F., The Effect of
Microtubule-targeting Chemotherapeutic Agents on the Surival of Bone-marrow
Derived Mesenchymal Stem Cell, 12th Research Postgraduate
Symposium, Hong Kong, 14 December 2007. |
|
Hui C.K., Cheung W.W., Leung K.W., Cheng V.C.C., Tang S.F., Li W.S., Lee N.P., Kwong Y.L., Au W.Y., Yuen K.Y., Lau G. and Liang R.H.S., Outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen, Hepatology. EPub, 2008. |
|
Khong
P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L. and Au W.Y., Fluorine-18 fluorodeoxyglucose
positron emission tomography in mature T-cell and antural killer cell
malignancies, 10th International Conference on Malignant Lymphoma, |
|
Khong P.L., Pang C.B.Y., Liang R.H.S., Kwong Y.L., Au W.Y. and Au W.Y., Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell , Annals of Hematology. E Pub, 2008, 87(8): 613-21. |
|
Ma
C.H., Ward A.C., Liang R.H.S.
and Leung A.Y.H., The role of jak |
|
Pang C.B.Y., Au W.Y., Chiu S.S.H., Liang R.H.S., Chan H.L.H. and Khong P.L., 18-F FDG PET-CT in mature T-cell and Natural-Keller (NK) cell lymphomas, 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007. |
|
Shen L., Au W.Y., Guo T., Wong K.Y., Wong M.L.Y., Tsuchiyama J., Yuen P.W., Kwong Y.L., Liang R.H.S. and Srivastava G., Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: an in vitro and in vivo preclinical evaluation, Blood. 2007, 110(1): 469-70. |
|
Yau T., Chan P., Chan Y., Wong B.C.Y., Liang R.H.S. and Epstein R., Review article: current management of metastatic colorectal cancer - the evolving impact of targeted drug therapies. , Aliment Pharmacol Ther. 2008, 27(11): 997-1005. |
|
Yau T.C., Chan P., Chan R., Wong B.C.Y., Liang R.H.S. and Epstein R., Current management of metastatic colorectal cancer: the evolving impact of targeted drug therapies., Aliment Pharm Ther. 2008, 27: 997-1005. |
|
Researcher
: Liao S |
|
List of Research Outputs |
|
Wu E.X., Wu Y., Nicholls J.M., Liao S., Lau C.P. and Tse H.F., MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model, In: Wu EX, Magn Reson Med. . 58(4), 2007, 687-95. |
|
Researcher
: Lie AKW |
|
List of Research Outputs |
|
Au
W.Y., Lam W.M., |
|
Au W.Y., Chan E. and Lie A.K.W., Hemopoietic stem cell transplantation from a donor with indeterminate HTLV-1 status, American Journal of Hematology. 2007, 82(6): 495. |
|
Au W.Y., Lie A.K.W., Cheng V.C.C., Cheng L.C., Wang E.P. and Wong C.F., Successful Lung Transplantation for Post-BMT Bronchiolitis Obliterans and Lipoid Pneumonia Associated with Atypical Mycobacterium and Aspergillosis Infection , The Journal of Heart and Lung Transplantation. 2007, 26(8): 870-872. |
|
Researcher
: Lin MC |
|
Project Title: |
Basic research on systemic damage in early stage and wound-healing after severe trauma |
|
Investigator(s): |
Lin MC |
|
Department: |
|
|
Source(s) of Funding: |
Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
|
Start Date: |
04/2001 |
|
Abstract: |
|
To study basic research on systemic damage in early stage and wound-healing after severe trauma. |
|
Project Title: |
Basic research on the mechanism of aging and the prevention of geriatric disease |
|
Investigator(s): |
Lin MC |
|
Department: |
|
|
Source(s) of Funding: |
Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
|
Start Date: |
12/2001 |
|
Abstract: |
|
To study the mechanism of aging and the prevention of geriatric disease. |
|
Project Title: |
Characterization of a novel cell cycle related kinase in glioblastoma |
|
Investigator(s): |
Lin MC, Leung SY, Ching YP |
|
Department: |
|
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2002 |
|
Abstract: |
|
The project aims at characterizing the role of cell cycle related kinase (CCRK) in cell cycle control, apoptosis, cell division and cell proliferation. Potential tumorigenic function of CCRK in human glioblastoma, fibroblast cell lines, and nude mice xenograft will also be investigated. |
|
Project Title: |
Molecular basis of alcohol-induced birth defects, the critical role of Pax 6 |
|
Investigator(s): |
Lin MC, Wong BCY, Yang JY, Peng Y |
|
Department: |
|
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To elucidate the signaling pathways leading to alcohol-mediated inhibition of Pax6 expression and to identify the targets downstream of Pax6 responsible for microcephaly. We are particularly interested in the involvements of the PI3 kinase pathways and the reactive oxygen species and reactive nitrogen species; to investigate the molecular mechanisms for alcohol-induced growth retardation, in particular its relationship with gut development; to study alcohol induced eye deformation; to screen for agents that protect against alcohol induced birth defects. |
|
Project Title: |
Characterization of HNF-1 Cis-element as a novel insulin negative responsive element and identification of a new anti-diabetic drug targeting this element |
|
Investigator(s): |
Lin MC, Lu L, Tam S |
|
Department: |
|
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To determine if the consensus HNF-1 element also displays negative insulin responsiveness; to determine the role of HNF1α versus HNF1β and mutant HNF-1α in this transcription regulation; to evaluate the therapeutic effects / molecular mechanisms of a new anti-diabetic drug targeting this INRE. |
|
Project Title: |
System biology study of a novel anti-angiogenesis polypeptide kringle 1 domain of hepatocyte growth factor |
|
Investigator(s): |
Lin MC, Yiu SM |
|
Department: |
Chemistry |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
Kringle domain, a protein module consists of 80 amino acids, function as recognition units for binding of other proteins in solution and on cells. Several of the kringle domain peptide including Angiostatin has been shown to exhibit anti-angiogenesis effect. Recently, my laboratory studied the cancer therapeutic effect of a novel anti-angiogenesis polypeptide, kringle 1 domain of human hepatocyte growth factor (HGFK1). We demonstrated that using a recombinant adeno-associated virus (AAV) carrying the HGFK1 gene (rAAV-HGFK1), we can significantly inhibited the proliferation, migration, and vessel tube formation of mice microvascular endothelial cells in vitro. More importantly, in an in vivo preclinical study conducted in rat orthotropic model of hepatocellular carcinoma (HCC), we showed that rAAV-HGFK1 is more potent than rAAV-Endostatin, the leading anti-angiogenesis gene, in prolonging the survival rate of the tumor bearing rats. Furthermore, rAAV-HGFK1 effectively inhibits tumor growth and metastasis. The objectives of the research proposal is to elucidate the molecular mechanisms underlie the anti-angiogenesis effect of HGFK1 polypeptide using System Biology approach, which will use bioinformatics to integrate data obtained from cDNA microarray experiments, Yeast two hybrid and Proteomic study. Multiple anti-angiogenesis molecules with different efficacies have been identified, however their underlying molecular mechansims remain elusive. These molecules potentially exert their effects through different signal pathways, with different interacting proteins and downstream targets. Information gained from this study will allow us to compare the molecular mechanisms of HGFK1 to that of the current leading anti-angiogenesis polypeptide Endostatin which has recently been reported using similar approaches (Abdollahi, A et al. Molecular Cell 13: 649-663, 2004). |
|
Project Title: |
Integrative
Cancer Biology: Study the Novel Function of Makorin |
|
Investigator(s): |
Lin MC |
|
Department: |
Chemistry |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Many of the developmental genes also play
important roles in carcinogenesis. Makorin-2 (HSPC070), originally isolated
from hematopoietic stem/progenitor cells, belongs to the makorin family of
genes that encode putative ribonucleoproteins. The function of makorin-2 is
not known. We have recently shown that Xenopus Makorin-2 (Xmakorin-2) is expressed
throughout embryonic development. Embryos over-expressing Xmakorin-2 mRNA
exhibited enhanced ventralization and knockdown of Xmakorin-2 caused
embryonic death. We further showed that expression of Xmakorin-2 induced
hematopoietic markers α-globin and GATA-1. As such, knockdown of Xmakorin-2
suppressed the expressions of α-globin and GATA-2. Furthermore, knockdown of Xmakorin-2
completely blocked BMP-4 induced α-globin expression. These results suggest
for the first time that Xmakorin-2 plays an important role in BMP-4 signaling
during Xenopus embryonic development (manuscript in preparation). Makorin-2
is characterized by a variety of zinc-finger motifs. To date, nine makorin
family loci have been identified and located throughout the human genome [1].
Makorin-2, located on chromosome 3p25, contains 8 exons and its nucleotide
sequence shares a sequence of 105bp in 3' UTR with the oncogene c-RAF gene in
reversed transcription orientation [2], suggesting that these two proteins
may regulate each other. Northern blot analysis showed that makorin-2 was
expressed in a variety of tissues, as well as in many of the cancer cell lines
examined [2]. These raised the possibility that makorin-2 may have important
roles in carcinogenesis. The objective is to use integrative cancer biology
approaches to explore the potential role of makorin |
|
Researcher
: Liu H |
|
List of Research Outputs |
|
Ho W.L., Ho W.M., Kwok H.H., Chu A.C.Y., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Brain uncoupling protein-2 mediates neuronal survival by leptin against mitochondrial dysfunction and ATP deficiency, 12th International Congress of Parkinson's disease and Movement Disorders, Chicago, USA. The Movement Disorder Society. 2008. |
|
Ho W.L., Chu A.C.Y., Kwok H.H., Liu H., Kung M.H.W., Ramsden D.B. and Ho S.L., Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells., Current Drug Metabolism. 2008, 9(4): 276-279. |
|
Researcher
: Liu L |
|
List of Research Outputs |
|
Liu L., Wang Y., Lam K.S.L. and Xu A., Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications, Endocr Metab Immune Disord Drug Targets (Invited review). 2008, 8: 89-98. |
|
Researcher
: Lo RLK |
|
List of Research Outputs |
|
Ho J.C.M., Lo R.L.K., Lam W.K. and Kwong Y.L., Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., AJRCCM 2008;177(10) Suppl. 2008, A463. |
|
Lo R.L.K., Lam W.K., Kwong Y.L. and Ho J.C.M., Best poster - Growth inhibitory activity of arsenic trioxide in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations., 13th Medical Research Conference. 2008. |
|
Researcher
: Lo WK |
|
List of Research Outputs |
|
Tang S.C.W., Ho Y.W., Tang A.W.C., Cheng Y.Y., Chiu F.H., Lo W.K., Lai K.N. and and for the HK PDSG , Delaying initiation of dialysis till symptomatic uraemia--is it too late? , Nephrology Dialysis Transplantation. 2007, 22: 1926-1932. |
|
Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
|
Researcher
: Lo Y |
|
List of Research Outputs |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Researcher
: Lo YYC |
|
List of Research Outputs |
|
Lo
Y.Y.C., Can West meet East?, In: Dr. E.Y.Y.
Tse, The Hong Kong Practitioner. Hong Kong, The |
|
Lo
Y.Y.C., Doctor, I was thinking the other
day..., In: Dr. E.Y.Y.Tse, The Hong Kong Practitioner. Hong Kong, The |
|
Lo
Y.Y.C., member, In: Dr. E.Y.Y.Tse, The
Hong Kong Practitioner. The |
|
Researcher
: Lu L |
|
List of Research Outputs |
|
Chen Y., Zhang H., Lu L. and Lau G., Role of Regulatory T cells in Natural Immunity and Sustained Pharmacological Control of Chronic HBV, 2007 Liver Meeting/American Association for the Study of Liver Diseases. 2008. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Lu L., Sun R.W., Chen R., Hui C.K., Ho C.M., Luk J.M.C., Lau G. and Che C.M., Silver nanoparticles inhibit hepatitis B virus replication, Antivir. Ther.. 2008, 13(2): 253-262. |
|
Researcher
: Lu L |
|
List of Research Outputs |
|
Chen Y., Zhang H., Lu L. and Lau G., Role of Regulatory T cells in Natural Immunity and Sustained Pharmacological Control of Chronic HBV, 2007 Liver Meeting/American Association for the Study of Liver Diseases. 2008. |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Lu L., Sun R.W., Chen R., Hui C.K., Ho C.M., Luk J.M.C., Lau G. and Che C.M., Silver nanoparticles inhibit hepatitis B virus replication, Antivir. Ther.. 2008, 13(2): 253-262. |
|
Researcher
: Lui SL |
|
List of Research Outputs |
|
Lui
S.L., Tsang
R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the
severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
|
Researcher
: Ma CH |
|
List of Research Outputs |
|
Ma
C.H., Ward A.C., Liang R.H.S. and Leung A.Y.H., The role of jak |
|
Researcher
: Ma J |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
|
Ma
J., Yang X.Y., Qiao L., Liang L.Q. and Chen M.H., CYP |
|
Ma
J., Yang X.Y., Qiao L., Liang L.Q. and Chen M.H., CYP |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
|
Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Researcher
: Mak JCW |
|
Project Title: |
Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro |
|
Investigator(s): |
Mak JCW, Tsang KWT |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To evaluate the effects of Pseudomonas aeruginosa (PA) exotoxins, pyocyanin (PYO) and 1-hydroxyphenazine (1-HP), on the functional and immunological aspects of human airway epithelial cells in vitro, and examine the signaling pathways involved in PYO- or 1-HP-induced responses; to assess the efficacy of various potential novel therapeutic and chemical agents on the effects of these toxins. |
|
Project Title: |
Role of
transforming growth factor-beta1 variants in susceptibility to tuberculosis
in |
|
Investigator(s): |
Mak JCW, Chan MMW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2005 |
|
Abstract: |
|
i) To study the role of two common single
nucleotide polymorphisms (SNPs) at the promoter (C-509T) and coding regions
(T |
|
Project Title: |
Role of
senescence marker protein |
|
Investigator(s): |
Mak JCW, Chan MMW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2007 |
|
Abstract: |
|
Chronic obstructive pulmonary disease
(COPD) is a major public health concern worldwide, and is projected to be the
third leading cause of mortality worldwide within 10 years [1]. COPD is a
disease characterized by slowly progressive development of airflow limitation
that is not fully reversible. The airflow limitation is associated with an
abnormal inflammatory response of the lungs to noxious particles or gases,
mainly from cigarette smoke [2]. Smoking accounts for 90% of cases of COPD,
but only 15% of smokers develop clinically symptomatic COPD [3]. There are no
therapies that can reduce the inevitable progression of this disease at
present. COPD is an age-related lung disease that occurs after a prolonged
period of cigarette smoking. Oxidative stress is an important feature of
COPD. Cigarette smoke is a rich source of oxidants containing over 1015 free
radicals/puff in both the gaseous and tar phase [4]. In patients with COPD,
biomarkers of oxidative stress, such as protein carbonyls and lipid
peroxidation products, are reported to be elevated in the lungs and
respiratory muscles [5,6]. Senescence marker protein-30 (SMP30) Senescence
marker protein-30 (SMP30), a 34-kD protein that decreases with age, is a
multifunctional protein providing protection to cellular functions from
age-associated deterioration [7]. It has been proposed as an important aging
marker and is functionally identified as a Ca2+ binding protein. In mice,
SMP30 transcripts are detected in various organs including lung [8]. In
humans, the SMP30 gene is located in the p11.3-q11.2 segment of the X
chromosome [9]. The SMP30 knockout (SMP30Y/-) mouse has been developed with
gene targeting from C57BL6 mice [10]. Recent findings showed that SMP30
protects mice lungs from oxidative stress, aging and smoking [11]. However,
the precise function of SMP |
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List of Research Outputs |
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Chan C.H., Shum D.K.Y., Tipoe G.L., Mak J.C.W., Leung T.M. and Ip M.S.M., Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis, Respiratory Medicine. 2008, 102: 287-298. |
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Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
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Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481. |
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Mak
J.C.W., Leung H.C.M., Sham A.S., Mok T.Y.,
Poon Y.N., Ling S.O., Wong K.C. and Chan
M.M.W., Genetic polymorphisms and plasma levels of transforming growth
factor-beta |
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Mak J.C.W., Ho S.P., Ho A.S.S., Law B.K., Ho J.C.M. and Chan M.M.W., Increased oxidative stress during acute asthma exacerbation in Hong Kong Chinese asthmatics, Pro Am Thorac Soc. 2008, 3: A472. |
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Mak J.C.W., Oxidant and antioxidant status in airway diseases, 2007. |
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Mak J.C.W., Pathogenesis of COPD. Part II. Oxidative-antioxidative imbalance, Int J Tuberc Lung Dis. 2008, 12: 368-374. |
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Mak
J.C.W., Ho
S.P., Yu W.C., Choo K.L., |
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Mak J.C.W., Ho S.P., Leung H.C., Cheung A.H.K., Law B.K., So L.K., Chan J.W., Chau C.H., Lam W.K., Ip M.S.M. and Chan M.M.W., Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. , Clin Exp Allergy. 2007, 37(8): 1150-7. |
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Researcher
: Mak W |
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List of Research Outputs |
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Chan K.H., Tsang K.L., Fong C.Y., Mak W. and Ho S.L., Clinical Outcome Of Relapsing Remitting Multiple Sclerosis In Hong Kong Chinese, Journal of Neurology. 2008, 255 (Suppl 2): 208 (Abstract). |
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Chan K.H., Chu A.C.Y., Kwok H.H., Ramsden D.B., Ho W.L., Kung M.H.W., Cheung R.T.F., Mak W. and Ho S.L., NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
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Chan K.H., Cheung R.T.F., Mak W. and Ho S.L., Nonthymoma early-onset and late-onset generalized myasthenia gravis - a retrospective hospital based study, Clinical Neurology and Neurosurgery. 2007, 109: 686-691. |
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Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
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Researcher
: Man YB |
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List of Research Outputs |
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Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
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Researcher
: Mok TMY |
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List of Research Outputs |
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Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436. |
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Mok T.M.Y., A patient with refractory mycobacterial disease, Commissioned Training in Pathology 2008. 2008. |
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Mok T.M.Y., A young patient presented with right leg swelling after recent airtravel, Beijing-Hong Kong Medical Forum 2008. 2008. |
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Mok
T.M.Y., Anti-cyclic citrullinated antibodies
, 3rd |
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Mok
T.M.Y., Anti-cyclic citrullinated antibodies
in the diagnosis and prognosis of rheumatoid arthritis , 3rd Conference of
Autoantibody |
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Mok
T.M.Y., Anti-cyclic citrullinated peptide
antibodies: novel diagnostic marker in rheumatoid arthritis, 7.5.2008 The |
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Mok T.M.Y., Anti-cytokine therapy in inflammatory arthritis, COC Pathology Commissioned Training Programme 2007/8 – Emerging trends in laboratory monitoring of infectious and inflammatory diseases. 2008. |
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Mok T.M.Y., Biologic therapy in treatment of rheumatoid arthritis, Beijing-Hong Kong Medical Forum 2008. 2008. |
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Mok T.M.Y., Cable TV: 致Fit男女 類風濕關節炎. 2008. |
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Mok
T.M.Y., Editor (2005-2009), In: The |
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Mok T.M.Y., Editor (since 2007), In: 《医学参考 - 风湿免疫专刊》, 中华人民共和国卫生部, 2007. |
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Mok T.M.Y., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis. , Annals of the Rheumatic diseases . 2008, 67: 499. |
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Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
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Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
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Mok T.M.Y., RTHK broadcast: 「陽光會館」年青人患風濕病. 2007. |
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Mok T.M.Y., Role of Cox-2 specific inhibitors in management of patients with arthritis , Annual Scientific Meeting 2007 of the Hong Kong Pain Society. 2007. |
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Mok
T.M.Y., Selection of serological test for
rheumatic complaints, Rheumatology Core Course, The |
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Mok
T.M.Y., Fung
P.C.W., Ooi C., Tse H.F., Wong
Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
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Mok T.M.Y., Update on Cox-2 inhibitors in the management of patients with arthritis, The Macau Orthopaedic Association. 2007. |
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Mok T.M.Y., What you need to know about SLE as a nursing professional, Hong Kong Association of Nursing Studies. 2008. |
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Mok T.M.Y., 健康創富. 2007. |
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Nie Y. and Mok T.M.Y., Immunosuppressive effects of human mesenchymal stem cells on systemic lupus erythematosus (SLE) T- and B- cells. , Annals of the Rheumatic diseases . 2008, 67: 350. |
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Researcher
: Ng CYC |
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List of Research Outputs |
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Cheung T.K., Lam B., Ip M.S.M., Kung R., Ng C.Y.C. and Wong B.C.Y., Gastro-esophageal reflux disease negatively impacted on asthma control, quality of life and psychological status in Chinese asthma patients, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
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Researcher
: Ng FH |
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List of Research Outputs |
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Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
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Ng
F.H., Wong
S.Y., Lam K.F., Chang P.C.M., Lau Y.K., |
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Ng
F.H., Lam
K.F., Wong S.Y., Chang P.C.M., Lau Y.K., Yuen W.C., |
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Researcher
: Ng MMT |
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List of Research Outputs |
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Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
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Researcher
: Ng MYM |
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List of Research Outputs |
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He Q., Zhu R., Lei T., Ng M.Y.M., Luk J.M.C., Sham P.C., Lau G. and Chiu J., Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma, Journal of Cellular Biochemistry. 2008, 103: 740-752. |
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Researcher
: Ng YCC |
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List of Research Outputs |
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Chan
D.T.M., Ng Y.C.C. and
Yung S.S.Y., Cytokine induction by
anti-DNA antibodies in proximal renal tubular epithelial cells is reduced by
mycophenolic acid, Journal of the American Society of Nephrology.
2007, 18: |
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Researcher
: Ngai WS |
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List of Research Outputs |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
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Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
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Researcher
: Nie Y |
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List of Research Outputs |
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Nie Y. and Mok T.M.Y., Immunosuppressive effects of human mesenchymal stem cells on systemic lupus erythematosus (SLE) T- and B- cells. , Annals of the Rheumatic diseases . 2008, 67: 350. |
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Researcher
: Ong KL |
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List of Research Outputs |
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Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
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Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
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Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
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Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
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Ong K.L., Tso A.W.K., Lam K.S.L. and Cheung B.M.Y., Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension, Hypertension. 2008, 51: 1142-8. |
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Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
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Researcher
: Ong KL |
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List of Research Outputs |
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Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
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Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
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Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
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Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
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Ong K.L., Tso A.W.K., Lam K.S.L. and Cheung B.M.Y., Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension, Hypertension. 2008, 51: 1142-8. |
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Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
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Researcher
: Pang AWK |
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List of Research Outputs |
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Au W.Y., Pang A.W.K., Lam K.Y., Song Y., Lam W.M., So J.C.C. and Kwong Y.L., G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors, Bone Marrow Transplantation. 2007, 40(7): 677-681. |
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Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
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Researcher
: Pang RWC |
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List of Research Outputs |
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Chim J.C.S., Pang R.W.C., Fung T.K., Choi C.L. and Liang R.H.S., Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma, Leukemia. 2007, 21: 2527–2536. |
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Pang R.W.C., Best Free Paper Award, Inaugural William and Elizabeth Dabies Foundation Trust International Meeting . 2008. |
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Pang R.W.C., Johnson P.J., Pawlik T.M., Monden M., Joh J.W. and Poon R.T.P., Biology of hepatocellular carcinoma, Annals of Surgical Oncology. Springer, 2008, 15(4): 962-971. |
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Pang R.W.C. and Poon R.T.P., From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now, Oncology. 2007, 72 Suppl 1: 30-44. |
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Pang R.W.C., Identification and characterization of tumorigenic and metastatic cancer stem cells in colorectal cancer. , Joint Research Retreat of Centres for Cancer Research, University of Hong Kong and Hong Kong University of Science and Technology . 2008. |
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Pang R.W.C., Identification and characterization of tumorigenic and metastatic cancer stem cells in colorectal cancer., Centres for Cancer Research HKU - HKUST Joint Retreat 2008, Centre for Cancer Research, HKU. 2008. |
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Pang R.W.C., Law W.L., Poon J.T.C., Fan J., Choi C.Y., Poon R.T.P. and Wong B.C.Y., Isolation and characterization of tumorigenic and metastatic cancer stem cells from human colorectal cancer, 13th Medical Research Conference, Department of Medicine, HKUHong Kong . 2008. |
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Pang R.W.C., Law W.L., Poon J.T.C., Fan J., Choi C.Y., Poon R.T.P. and Wong B.C.Y., Isolation and characterization of tumorigenic and metastatic cancer stem cells from human colorectal cancer, Inaugural William and Elizabeth Dabies Foundation Trust International Meeting. 2008. |
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Pang
R.W.C., Li Ka Shing Prize, The |
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Pang R.W.C., Kwong Y.L. and Tse E.W.C., Pin1-HBx interaction: a step toward understanding the significance of hepatitis B virus genotypes in hepatocarcinogenesis., Gastroenterology. Elsevier, 2007, 133(2): 728-729. |
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Pang R.W.C., Postgraduate Course Lecture. Searching for novel therapeutic agents in hepatocellular carcinoma. , Shanghai-Hong Kong International Liver Congress. 2008. |
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Pang R.W.C., Symposium Lecture. Signaling Catastrophy in Hepatocarcinogenesis: The Role of Hepatitis B and Beyond. , 2008. |
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Pang
R.W.C., Symposium Lecture. Signaling
catastrophy in hepatocelluar carcinoma: The role of hepatitis B and beyond. ,
Hong Kong International Cancer Congress 2007, |
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Pang
R.W.C., The role of helicobacter pylori in
the eradication of gastric cancer., Annual Meeting of American Association
of Cancer Research, |
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Poon R.T.P., Tso W.K., Pang R.W.C., Ng K.K.C., Woo R., Tai K.S. and Fan S.T., A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead, Clinical Gastroenterology and Hepatology. 2007, 5(9): 1100-1108. |
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Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
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Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Researcher
: Qiao L |
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Project Title: |
Simultaneous activation of PPARgamma and inhibition of XIAP in human colorectal cancer cells: effects on apoptosis and angiogenesis |
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Investigator(s): |
Qiao L, Wong BCY |
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Department: |
Medicine |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
05/2006 |
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Abstract: |
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Colorectal cancer (CRC) is the fourth
most common malignancies world wide. The estimated annual incidence of CRC is
1 million cases. Although the highest incidences of CRC are in developed
countries such North America, Australia/New Zealand, Western Europe, and |
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List of Research Outputs |
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Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
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Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
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Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
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Ma J.,
Yang X.Y., Qiao L., Liang L.Q.
and Chen M.H., CYP |
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Ma J.,
Yang X.Y., Qiao L., Liang L.Q.
and Chen M.H., CYP |
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Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
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Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
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Qiao
L., Li
H.Y., Li Z., Zou B. and Wong B.C.Y., Gene expression profile in
colon cancer cells in response to troglitazone: impact of XIAP expression, Digestive
Disease Week, |
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Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
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Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
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Song Y., Liu Q., Shen H., Jia X., Zhang H. and Qiao L., Diagnosis and management of primary aortoenteric fistulas--experience learned from eighteen patients, Surgery. 2008, 143: 43-50. |
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Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
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Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
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Zhou Y.N., Zhang Z.H.I.Y.I., Zhang Z.K., Wu J., Ren D.X., Yan X., Wang Q., Wang Y.L., Wang H.Z., Zhang J., Zhu X.L., Yang Y.C., Luo C., Guo X., Tang C.W. and Qiao L., A rising trend of gastric cardia cancer in Gansu Province., Cancer Letters. 2008, 269: 18-25. |
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Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Researcher
: Qiuwaxi J |
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List of Research Outputs |
|
Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells in patients with type II diabetes. , Mol Nutr Food Res (in press). 2008. |
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Researcher
: Ren Y |
|
Project Title: |
Proteomics computational analysis of Severe Acute Respiratory Syndrome |
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Investigator(s): |
Ren Y, Tam PKH, Peiris JSM, He Q |
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Department: |
Surgery |
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Source(s) of Funding: |
VCO SARS Research Fund |
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Start Date: |
07/2003 |
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Abstract: |
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To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells. |
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Researcher
: Shek SYN |
|
List of Research Outputs |
|
Yu C.S., Yeung C.K., Shek S.Y.N., Tse R.K., Kono T... and Chan H.H.L., Combined infrared light and bipolar radiofrequency for skin tightening in Asians., Lasers in Surgery and Medicine. 2007, 39(6): 471-5. |
|
Researcher
: Shen J |
|
Project Title: |
Effects of Buyang Huanwu Decoction on neuronal regeneration after ischemic brain injury |
|
Investigator(s): |
Shen J, Fung PCW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To evaluate the effects of Buyang Huanwu Decoction, a classical formula of Traditional Chinese Medicine (TCM), and its major component Astragalus membranaceus on the regeneration of neurons after ischemic brain injury. |
|
Researcher
: Shiu SWM |
|
List of Research Outputs |
|
Tam H.L., Shiu S.W.M., Chow W.S., Wong Y. and Tan K.C.B., Effect of atorvastatin on serum soluble receptor for advanced glycation end products in type 2 diabetes, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Tan K.C.B., Shiu S.W.M., Chow W.S., Leng L., Bucala R. and Betteridge D.J., Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 49: 2756-62. |
|
Tan K.C.B., Shiu S.W.M., Huang Y. and Wong Y., Effect of insulin on endothelial lipase in type 2 diabetes, The 7th International Diabetes Federation Western Pacific Region Congress, Wellington, New Zealand. 2008. |
|
Tan K.C.B., Zhou H., Shiu S.W.M. and Wong Y., Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus, American Diabetes Association 68th Scientific Sessions, San Francisco, USA. 2008. |
|
Researcher
: Shiu WMS |
|
List of Research Outputs |
|
Shiu W.M.S., Wong Y., Bucala R. and Tan K.C.B., Glyoxidized low-density
lipoprotein upregulates soluble lectin-like oxidized ldl receptor |
|
Shiu W.M.S., Tan K.C.B., Huang Y. and Wong Y., Type 2 diabetes mellitus and endothelial lipase, Atherosclerosis . 2008, 198: 441-7. |
|
Zhou H., Tan K.C.B., Shiu W.M.S. and Wong Y., Increased serum advanced glycation end products is associated with impairment in HDL antioxidative capacity in diabetic nephropathy, Nephrol Dial Transplant. 2008, 23: 927-33. |
|
Researcher
: Siu DCW |
|
List of Research Outputs |
|
Au K.W., Siu D.C.W., Lau C.P., Tse H.F. and Li R.A., Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions, American Journal of Physiology Cellular Physiology . 2007, 294(1): C136-144. |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Siu D.C.W., Au K.W., Lau C.P., Tse H.F. and Li R.A., Dynamic Conformational changes of the P-S6 linker of the packemakers (HCN) Channels identified by sulfhydryl modification: Port-to-gate coupling model , Heart Rhythm . 2008, 5, No. 5 May Supplement. |
|
Siu D.C.W., Zhang X., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., Recurrence of Atrial Fibrillation in hyperthyroidism related atrial fibrillation: A matched case-control study., Heart Rhythm Society Scientific Meeting 2008. |
|
Tse
H.F. and Siu D.C.W.,
Ground-breaking Paper of 2006 (one of three chosen) in American Heart
Association Annual Scientific Meeting 2007: “Bioartificial sinus node
constructed via in vivo gene transfer of an engineered pacemaker HCN channel
reduces the dependence on electronic pacemaker in a sick sinus syndrome
model. Circulation. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Tse H.F., Kwok K.W., Siu D.C.W., Tang M.O., Ho W.Y. and Lau C.P., Ventricular Rate regularization with right ventricular septal pacing preserves left ventricular function and improves exercise capacity in patients with permanent atrial fibrillation , Heart Rhythm . 2008, 5,No. 5 May Supplement. |
|
Wang
M.M., Tse H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in Inter-atrial
Dyssynchrony and Atrial Mechanical Function in Sick Sinus Syndrome with or
without Paroxysmal Atrial Fibrillation (Oral presentation), The American
Heart Assosiation Scientific Sessions |
|
Wang M.M., Lau C.P., Siu D.C.W., Lee K.L.F. and Tse H.F., Differential in inter-atrial dyssynchrony and atrial mechanical function in sick sinus syndrome with or without paroxysmal atrial fibrillation., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang M.M., Tse H.F., Siu D.C.W., Lee K.L.F. and Lau C.P., Improvement of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang
M.M., Siu D.C.W., Zhang X., Lau C.P. and Tse H.F., Is atrial dyssynchrony
important in sinus node disease with or without atrial fibrillation?, The
American Society of Echocardiography, |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
|
Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
|
Zhang X., Chen H., Siu D.C.W., Yiu K.H., Chan W.S., Lee K.L., Chan H.W., Lee S.W., Fu G.S., Lau C.P. and Tse H.F., New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function., Journal of Cardiovascular Electrophysiology. 2008, 19(2): 136-141. |
|
Researcher
: Song L |
|
List of Research Outputs |
|
Song L., Koo M.W.L., Cheung B.M.Y. and Lau C.P., Effects of green tea on hypercholesterolemia induced hypertension in rats, Southeast Asian Western Pacific Regional Federation of Pharmacologists and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Meeting. 2007. |
|
Researcher
: Sum SM |
|
List of Research Outputs |
|
Yuan H.J., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E., Lai C.L. and Yuen R.M.F., Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B, J Infect . 2007, 54: 497-503. |
|
Researcher
: Sun H |
|
List of Research Outputs |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Li
G.R., Sun H. and Lau C.P., Characterization of ion
channels in human cardiac fibroblasts. , Biophys J / 52nd Annual Meeting
and 16th International Biophysical Congress, |
|
Tang Q., Jin M.W., Xiang J.Z., Dong M., Sun H., Lau C.P. and Li G.R., The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. , Biochem Pharmacol. 2007, 74(11): 1596-607. |
|
Researcher
: Sun Y |
|
List of Research Outputs |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Researcher
: Tam HL |
|
List of Research Outputs |
|
Tam H.L., Shiu S.W.M., Chow W.S., Wong Y. and Tan K.C.B., Effect of atorvastatin on serum soluble receptor for advanced glycation end products in type 2 diabetes, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
List of Research Outputs |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Chan W.L., Leung J.C.K., Chan L.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects polymeric IgA
induced mesangial cells injury in IgAN: roles of smad6 and PPAR-gamma, Journal
of American Society of Nephrology. 2007, 18: |
|
Researcher
: Tam S |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431. |
|
Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
|
Chu L.W., Tam S., Kung A.W.C., Lo S., Fan S., Wong L.C., Morley J.E. and Lam K.S.L., Serum total and bioavailable testosterone levels, central obestiy and muscle strength changes with aging in healthy Chinese men, Journal of American Geriatrics Society. 2008, 56(7): 1286-1291. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Li H., Li X., Lam K.S.L., Tam S., Xiao W. and Xu R., Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats, J Biomed Sci.. 2008, Epub ahead of print. |
|
Researcher
: Tan KCB |
|
Project Title: |
Advanced glycation end products and diabetic complications |
|
Investigator(s): |
Tan KCB |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2002 |
|
Abstract: |
|
Hyperglycaemia leading to the increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in causing many of the complications of diabetes. In this project, the research team plan to explore the underlying mechanisms whereby AGEs may cause defective endothelium-dependent vasodilation. |
|
Project Title: |
HDL dysfunction and diabetes mellitus |
|
Investigator(s): |
Tan KCB |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Background Epidemiological studies have
shown that plasma HDL cholesterol levels are strongly inversely associated
with cardiovascular disease and HDL is thought to play a protective role
against atherosclerosis. The antiatherogenic properties of HDL include
promotion of cellular cholesterol efflux and reverse cholesterol transport,
as well as antioxidant, anti-inflammatory and anticoagulant properties (1).
In addition to promoting efflux of excess cholesterol from cells in the
arterial wall and returning cholesterol to the liver for excretion into the
bile, HDL inhibits lipid oxidation, reduces the inflammatory response of
endothelial cells, promotes the availability of nitric oxide, and inhibits
the coagulation pathway. The magnitude of these protective effects of HDL are
determined not only by its circulating levels, but also in part by the
qualitative function of the HDL species (1,2), and compositional changes in
HDL can result in a loss of many of its antiatherogenic properties (3).
Functional assays have recently been developed to determine the
antiatherogenic profile of an individual’s HDL by measuring the ability of
HDL to inactivate and/or to prevent the formation of oxidized lipids (4). HDL
dysfunction has been reported in subjects with coronary heart disease (5) and
we have recently demonstrated HDL dysfunction in subjects with obstructive
sleep apnoea (6). Problems to be addressed and objectives: Patients with type
2 diabetes mellitus frequently have low HDL cholesterol levels and studies
involving small number of diabetic subjects have suggested that HDL is
dysfunctional in diabetes mellitus. Gowri et al showed that HDL2 exhibited
decreased protection against THP1 macrophage-mediated LDL oxidation in 10
poorly controlled type 2 diabetic patients (7), whereas Nobecourt et al
reported that it was the antioxidative activity of small dense HDL3 (and not
HDL2) that was deficient in 20 well-controlled type 2 diabetic patients (8).
What accounts for the observed differences between these studies is not clear
and whether HDL dysfunction is related to glycaemic control and/or to the
presence of diabetic complications has not been investigated. Functional
abnormalities in HDL have also been described in non-diabetic patients with
chronic kidney disease (9). Hence, the objectives of this study are (i) to
determine whether HDL dysfunction is related to the presence of diabetic
nephropathy (both incipient and overt) and its association with the degree of
albuminuria. If HDL dysfunction is found to relate to the severity of
diabetic nephropathy, does HDL dysfunction improve when diabetic nephropathy
is being treated with agents that block the renin-angiotensin system? (ii) Is
HDL dysfunction more severe in poorly controlled type 2 diabetic patients?
Can it be reversed by improving glycaemic control and is HDL dysfunction due
to abnormalities in the intrinsic physicochemical properties of HDL and/or to
changes in HDL associated enzymes such as paraoxonase and platelet-activating
factor acetylhydrolase which are involved in catalyzing the breakdown of
oxidized phospholipids? References: 1) Wang M, Briggs MR. HDL: The
metabolism, function, and the therapeutic importance. Chem Rev 2004;104:119-37
2) Rohrer L, Hersberger M, von Eckardstein A. High density lipoproteins in
the intersection of diabetes mellitus, inflammation and cardiovascular
disease. Curr Opin Lipidol. 2004;15:269-78. 3) Van Lenten BJ, Hama SY, de
Beer FC et al. Anti-inflammatory HDL becomes pro-inflammatory during the
acute phase response. Loss of protective effect of HDL against LDL oxidation
in aortic wall cell cocultures. J Clin Invest. 1995;96:2758-67. 4) Navab M, |
|
Project Title: |
Glycosidized LDL and atherosclerosis |
|
Investigator(s): |
Tan KCB, Tam S |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2005 |
|
Abstract: |
|
To investigate the effects of glycosidized LDL on foam cell formation and reverse cholesterol transport; to evaluate glycosidized LDL as an inflammatory stimulus; to test clinical strategies to lower glycosidized LDL. |
|
Project Title: |
Adenosine triphosphate-binding cassette transporters and cholesterol efflux in diabetes |
|
Investigator(s): |
Tan KCB |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
A low high density lipoprotein (HDL)
level is an important risk factor for coronary heart disease and HDL plays a
protective role against atherosclerosis by promoting cellular cholesterol
efflux and reverse cholesterol transport (RCT). Reverse cholesterol transport
is a pathway which transports cholesterol from extrahepatic cells and tissues
to the liver for excretion, and consists of multiple steps involving a number
of HDL subclasses, lipolytic enzymes, lipid transfer proteins, cellular
receptors and transporters [1]. Efflux of cholesterol from macrophages is
particularly important with regard to atherosclerosis and is mediated by
lipid transporters/receptors including adenosine triphosphate-binding
cassette transporters (ATP-binding cassette transporters) and scavenger
receptor class B, type 1 (SR-B1) [2]. The recent discovery that mutations in
the human ATP-binding cassette transporter ABCA1 gene are the underlying molecular
defect in HDL deficiency syndromes such as Tangier disease has improved our
understanding of the role of lipid transporters in RCT [3,4]. Targeted
disruption of ABCA1 results in a virtual absence of HDL cholesterol while
ABCA1 overexpression increases HDL levels [2-4]. ABCA1 mainly mediates the
efflux of cholesterol from cells to apolipoprotein (apo) A1 and a newly
discovered ATP-binding cassette transporters ABCG1 has been shown to mediate
net mass efflux of cellular cholesterol to mature HDL but not to lipid-poor
apo A1 [4,5]. ABCG1 knockout mice have marked macrophage cholesterol
accumulation whereas ABCG1 overexpression protects tissues from cholesterol
accumulation [6]There are recent data suggesting that ABCA1-mediated
cholesterol efflux may be impaired in diabetes mellitus. Due to
hyperglycaemia and enhanced oxidative stress, there is increased formation of
advanced glycation end products in diabetes and Passarelli et al have shown
that the advanced glycation end product precursors impair ABCA1-dependent
cholesterol removal from cells in vitro [7]. Albrecht et al have reported
that leucocyte ABCA1 gene expression was inversely associated with indices of
glycemia in non-diabetic normoglycemic men in vivo [8]. Taken together, these
data suggest that ABCA1-mediated cholesterol efflux may potentially be
abnormal in diabetes mellitus. Whether ABCG1-mediated cholesterol efflux is
similarly affected is not known. The rate of cellular cholesterol efflux is
dependent not only on the lipid transporters but also on the availability of
acceptors of cholesterol in the circulation. Plasma HDL has in the past been
viewed as a universal plasma acceptor lipoprotein for cholesterol removed
from cells. However, it is increasingly being recognized that plasma level of
HDL cholesterol or apolipoprotein (apo) AI per se does not reflect the
capacity or efficiency of cholesterol efflux [9]. For instance, in patients
with type IIb and type IV hypertriglyceridaemia associated with low HDL, it
has been shown that the capacity of sera from these subjects to induce efflux
of cholesterol from SR-B1 rich Fu5AH cells was not reduced and type IV
patients' sera in fact induced a markedly higher increase in ABCA1-mediated
efflux compared to that of control [10]. The regulation of cholesterol efflux
in vivo remains poorly understood. Despite the high cardiovascular risk in
patients with diabetes, current knowledge about abnormalities in cholesterol
efflux in diabetes is limited. De Vries et al reported that in type 1
diabetic patients with moderate hypercholesterolaemia, the capacity of plasma
to induce cholesterol efflux out of Fu5AH cells via SR-B1 and out of
fibroblasts expressing ABCA1 was enhanced. The relatively higher stimulatory
effect of diabetic plasma on cholesterol efflux out of Fu5AH cells compared
to fibroblasts suggested that plasma from type 1 diabetic patients
predominantly enhanced SR-B1-mediated efflux [11]. On the other hand, in type
2 diabetes, Syvanne et al demonstrated that cholesterol efflux from Fu5AH
cells induced by plasma was impaired in diabetic patients with coronary heart
disease [12]. There are no data on whether ABCA1 or ABCG1-mediated
cholesterol efflux is abnormal in type 2 diabetes or whether it is in fact
enhanced to compensate for the reduction in the SR-B1 pathway. The objectives
of this study are: 1) to investigate whether monoctye/macrophage ABCA1 and
ABCG1 expression is reduced in patients with type 2 diabetes and its
relationship to hyperglycaemia; 2) to determine whether there are changes in
the capacity of plasma to induce cholesterol efflux via ABCA1 and ABCG |
|
List of Research Outputs |
|
Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
|
Shiu
W.M.S., Wong Y., Bucala R. and Tan K.C.B., Glyoxidized low-density
lipoprotein upregulates soluble lectin-like oxidized ldl receptor |
|
Shiu W.M.S., Tan K.C.B., Huang Y. and Wong Y., Type 2 diabetes mellitus and endothelial lipase, Atherosclerosis . 2008, 198: 441-7. |
|
Tam H.L., Shiu S.W.M., Chow W.S., Wong Y. and Tan K.C.B., Effect of atorvastatin on serum soluble receptor for advanced glycation end products in type 2 diabetes, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Tan
K.C.B., Achieving Glycemic Control without
Therapeutic Compromises, he Hong Kong |
|
Tan K.C.B., Shiu S.W.M., Chow W.S., Leng L., Bucala R. and Betteridge D.J., Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 49: 2756-62. |
|
Tan K.C.B., Board Member, Specialty Board in Endocrinology, Diabetes and Metabolism, Hong Kong College of Physicians. 2007. |
|
Tan
K.C.B., Chairman of symposium “Hong Kong
Atheroslcerosis Society Symposium”, The 9th Hong Kong Diabetes and
Cardiovascular Risk Factors - East Meets West Symposium, |
|
Tan
K.C.B., Chairman of symposium “What clinical
trials are needed ?”, The 7th International Diabetes Federation Western
Pacific Region Congress, |
|
Tan K.C.B., Chairman of the Organising Committee, 3rd International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Tan
K.C.B., Convenor, |
|
Tan K.C.B., Council Member, Asian Pacific Society of Atherosclerosis and Vascular Disease. 2007. |
|
Tan
K.C.B., Council Member, Diabetes Division
of |
|
Tan K.C.B., Council Member, Institute of Cardiovascular Science and Medicine. 2007. |
|
Tan K.C.B., Shiu S.W.M., Huang Y. and Wong Y., Effect of insulin on endothelial lipase in type 2 diabetes, The 7th International Diabetes Federation Western Pacific Region Congress, Wellington, New Zealand. 2008. |
|
Tan K.C.B., From Science to Clinical Application: Sitagliptin, a Selective DPP-4 Inhibitor in Diabetes Management, CME Meeting for Physicians, Hong Kong. 2007. |
|
Tan
K.C.B., Honorary Treasurer and Council
Member, |
|
Tan K.C.B., Zhou H., Shiu S.W.M. and Wong Y., Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus, American Diabetes Association 68th Scientific Sessions, San Francisco, USA. 2008. |
|
Tan K.C.B., Management of Dyslipidaemia: What is new in current management strategy?, Advances in Medicine, Hong Kong. 2008. |
|
Tan K.C.B., New Pharmaological Treatment in Obesity, Certificate Course on Update on Diabetes Management, Hong Kong. 2007. |
|
Tan
K.C.B., New trends and paradigms of using ARB
in hypertension, Macau Diabetes Association, |
|
Tan K.C.B., Reviewer, Atheroscleorsis. 2007. |
|
Tan K.C.B., Reviewer, British Journal of Clinical Pharmacology. 2007. |
|
Tan K.C.B., Reviewer, Circulation. 2007. |
|
Tan K.C.B., Reviewer, Clinical Chemistry. 2007. |
|
Tan K.C.B., Reviewer, Diabetes. 2007. |
|
Tan K.C.B., Reviewer, Diabetes Research and Clinical Practice. 2007. |
|
Tan K.C.B., Reviewer, Diabetes, Obesity and Metabolism. 2007. |
|
Tan K.C.B., Reviewer, Diabetic Medicine. 2007. |
|
Tan K.C.B., Reviewer, Hong Kong Medcial Journal. 2007. |
|
Tan
K.C.B., Reviewer, |
|
Tan
K.C.B., Reviewer, Journal of American
Medical Association ( |
|
Tan K.C.B., Reviewer, Journal of Clincial Endocrinology and Metabolism. 2007. |
|
Tan K.C.B., Reviewer, QJM - An International Journal of Medicine. 2007. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Tan K.C.B., Treating dyslipidemia in the metabolic syndrome, Invited commentary for the International Atherosclerosis Society Website www.athero.org and Metabolic Syndrome Institute Website www.metabolic-syndrome-institute.com. 2007. |
|
Tan
K.C.B., Type I diabetes mellitus: updates on
aetiology and management, 2007 |
|
Tan
K.C.B., Vice President, |
|
Zhou H., Tan K.C.B., Shiu W.M.S. and Wong Y., Increased serum advanced glycation end products is associated with impairment in HDL antioxidative capacity in diabetic nephropathy, Nephrol Dial Transplant. 2008, 23: 927-33. |
|
Researcher
: Tang CSO |
|
List of Research Outputs |
|
Chan
D.T.M., Lin A.W., Tang S.C.W.,
Qian J.Q., Lam M.F., Ho Y.W., Tse K.C., Chan
K.W., Lai K.N. and Tang C.S.O., Prospective controlled
study on mycophenolate mofetil and prednisolone in the treatment of membranous
nephropathy with nephrotic syndrome, Nephrology. |
|
Researcher
: Tang CW |
|
Project Title: |
Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors |
|
Investigator(s): |
Tang SCW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To explore in vitro the effect of ACEI, ARB, and statins, either singly or in combination, on albumin-induced expression of IL-8, MCP-1 RANTES, and MIF incultured human PTEC; to dissect the intracellular signal transduction pathway governing the anti-inflammatory effects of these pharmacological agents; to investigate the I>in vitro impact of applying combined a ngiotensin II b blockade and statin treatment on enphrotic mice. |
|
Project Title: |
Measurement of upper airway water content in continuous ambulatory or nocturnal peritoneal dialysis and after renal transplantation: implications on sleep apnea |
|
Investigator(s): |
Tang SCW, Lam B, Khong PL, Pang CBY, Ku PP, Ip MSM, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2007 |
|
Abstract: |
|
In developed countries, sleep apnea has
emerged as an important health hazard with serious socioeconomic
implications. Sleep apnea is an important risk factor for stroke and sudden
cardiac death (1), and is strongly associated with the risk of road traffic
accidents (2). The issue may be even more relevant in nephrology because some
of the factors involved in the pathogenesis of renal disease are the same
that cause, or are associated with, sleep apnea. Indeed, sleep disorders such
as daytime sleepiness, insomnia, restless legs syndrome, and obstructive
sleep apnea syndrome are common in patients with end-stage renal disease
(ESRD) (3-5). In patients on continuous ambulatory peritoneal dialysis
(CAPD), the prevalence of sleep apnea ranges from 61 to 67% (6,7). In
patients on stable maintenance conventional hemodialysis, conversion to
nocturnal hemodialysis has been shown to correct sleep apnea associated with
chronic renal failure (8). However, this may not be practical in places where
nocturnal hemodialysis facilities are not readily available, or where
peritoneal dialysis (PD) is the predominant mode of renal replacement
therapy, such as |
|
List of Research Outputs |
|
Tse H.F., Kwok K.W., Siu D.C.W., Tang M.O., Ho W.Y. and Lau C.P., Ventricular Rate regularization with right ventricular septal pacing preserves left ventricular function and improves exercise capacity in patients with permanent atrial fibrillation , Heart Rhythm . 2008, 5,No. 5 May Supplement. |
|
Researcher
: Tang Q |
|
List of Research Outputs |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Li
G.R., Jin M.W., Tang Q.,
Qin G.W., Wang H.B., Zhang X.H., Tse H.F.
and Lau C.P., The natural compound
acacetin prolongs refractory period and prevents experimental atrial
fibrillation in anesthetized dogs. , Am J Coll Cardiol/ACC.08, |
|
Tang Q., Jin M.W., Xiang J.Z., Dong M., Sun H., Lau C.P. and Li G.R., The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. , Biochem Pharmacol. 2007, 74(11): 1596-607. |
|
Tang
Q., Jin M.W., Xiang J.Z., Dong M.Q., Lau C.P. and Li G.R., The membrane permeable calcium
shelator BAPTA-AM directly blocks hERG channels stably expressed in HEK 293
cells. , 9th National Symposium of Chinese Cardiovascular Pharmacological
Society. |
|
Researcher
: Tang SCW |
|
Project Title: |
Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors |
|
Investigator(s): |
Tang SCW |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To explore in vitro the effect of ACEI, ARB, and statins, either singly or in combination, on albumin-induced expression of IL-8, MCP-1 RANTES, and MIF incultured human PTEC; to dissect the intracellular signal transduction pathway governing the anti-inflammatory effects of these pharmacological agents; to investigate the I>in vitro impact of applying combined a ngiotensin II b blockade and statin treatment on enphrotic mice. |
|
Project Title: |
Measurement of upper airway water content in continuous ambulatory or nocturnal peritoneal dialysis and after renal transplantation: implications on sleep apnea |
|
Investigator(s): |
Tang SCW, Lam B, Khong PL, Pang CBY, Ku PP, Ip MSM, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2007 |
|
Abstract: |
|
In developed countries, sleep apnea has
emerged as an important health hazard with serious socioeconomic
implications. Sleep apnea is an important risk factor for stroke and sudden
cardiac death (1), and is strongly associated with the risk of road traffic
accidents (2). The issue may be even more relevant in nephrology because some
of the factors involved in the pathogenesis of renal disease are the same
that cause, or are associated with, sleep apnea. Indeed, sleep disorders such
as daytime sleepiness, insomnia, restless legs syndrome, and obstructive
sleep apnea syndrome are common in patients with end-stage renal disease
(ESRD) (3-5). In patients on continuous ambulatory peritoneal dialysis (CAPD),
the prevalence of sleep apnea ranges from 61 to 67% (6,7). In patients on
stable maintenance conventional hemodialysis, conversion to nocturnal
hemodialysis has been shown to correct sleep apnea associated with chronic
renal failure (8). However, this may not be practical in places where
nocturnal hemodialysis facilities are not readily available, or where
peritoneal dialysis (PD) is the predominant mode of renal replacement
therapy, such as |
|
List of Research Outputs |
|
Chan
D.T.M., Lin A.W., Tang S.C.W.,
Qian J.Q., Lam M.F., Ho Y.W., Tse K.C., Chan
K.W., Lai K.N. and Tang C.S.O., Prospective controlled
study on mycophenolate mofetil and prednisolone in the treatment of
membranous nephropathy with nephrotic syndrome, Nephrology. |
|
Chan L.Y., Leung J.C.K., Zhang C., Tang S.C.W. and Lai K.N., Angiotensin II type 2
receptor-mediated ERK inhibition protects tubular epithelial cells from
pro-inflammatory damage, Journal of American Society of Nephrology.
2007, 18: |
|
Chan W.L., Leung J.C.K., Chan Y.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects mesangial cells from injury by polymeric IgA, Kidney International. 2008, Epub May 2008. |
|
Chan W.L., Leung J.C.K., Chan L.Y., Tam K.Y., Tang S.C.W. and Lai K.N., BMP-7 protects polymeric IgA
induced mesangial cells injury in IgAN: roles of smad6 and PPAR-gamma, Journal
of American Society of Nephrology. 2007, 18: |
|
Lai K.N., Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Lai F.M. and Tang S.C.W., Activation of podocytes by mesangial-derived TNF-{alpha}: glomerulo-podocytic communication in IgA nephropathy, American Journal of Physiology Renal Physiology. 2008, 294: F945-F955. |
|
Leung
J.C.K., Tang S.C.W., Chan
L.Y., Lam M.F. and Lai K.N., CTGF
regulation amongst peritoneal cells under the context of CAPD, Journal of
American Society of Nephrology. 2007, 18: |
|
Leung J.C.K., Chan L.Y., Tang S.C.W., Tam P.C., Fenn J. and Lai K.N., Glycosylation profile of differently charged IgA1 and their binding characteristics to cultured mesangial cells in IgA nephropathy, Nephron Experimental Nephrology . 2007, 107: 107-118. |
|
Leung
J.C.K., Tang S.C.W., Lam
M.F., Chan Y.Y. and Lai K.N., Serum and spent peritonitis
fluid concentration of neutrophil gelatinase-associated lipocalin (NGAL) in
peritonitis, Peritoneal Dialysis International. |
|
Leung J.C.K., Tang S.C.W., Chan Y.Y., Chan W.L. and Lai K.N., Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA-role of MAPK and NFkB, Nephrology Dialysis Transplantation. 2008, 23: 72-81. |
|
Tang S.C.W., Leung J.C.K., Chan L.Y., Eddy A.A. and Lai K.N., ACEi suppresses angiotensin II-induced MAPK activation and TGF-β secretion in cultured PTEC, Proceedings of The World Congress of Nephrology. 2007, 368. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Eddy A.A. and Lai K.N., Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy, Kidney International. 2008, 73: 288-299. |
|
Tang
S.C.W., Best Presenter Medal, Annual Scientific
Meeting, |
|
Tang S.C.W., Chronic Kidney Disease, Hospital Authority Strategic Renal Service Planning Workshop. 2008. |
|
Tang S.C.W., Ho Y.W., Tang A.W.C., Cheng Y.Y., Chiu F.H., Lo W.K., Lai K.N. and and for the HK PDSG , Delaying initiation of dialysis till symptomatic uraemia--is it too late? , Nephrology Dialysis Transplantation. 2007, 22: 1926-1932. |
|
Tang
S.C.W., Development of Nephrology Research in
Hong Kong, |
|
Tang
S.C.W., Distinguished Research Paper Award
for Young Clinicians. Cash Prize: HK$ 5,000, |
|
Tang S.C.W. and Lai K.N., Does automated peritoneal dialysis provide better outcomes than continuous ambulatory peritoneal dialysis?, Nature Clinical Practice Nephrology. 2007, 3: 596-597. |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Tang S.C.W., Improving Bone and Cardiovascular Outcomes in Chronic Dialysis, HA-commissioned Renal Training Programme 2008. 2008. |
|
Tang
S.C.W., Leung
J.C.K., Chan L.Y., Yuen Y.M. and Lai
K.N., PPAR-gamma agonist reduces intrarenal injury and inflammation in
genetically diabetic db/db mice with accelerated glomerular and
tubulo-interstitial lesions, Journal of American Society of Nephrology.
2007, 18: |
|
Tang S.C.W., Subject Editor, Nephrology. Blackwell Publishing, 2008. |
|
Tang S.C.W., Targeting the renin-angiotensin system, Hong Kong Journal of Nephrology . 2007, 9: 1-2. |
|
Tang
S.C.W., Ten Outstanding Young Persons Award ,
Junior Chamber International |
|
Tang S.C.W. and Lai K.N., Tired but can’t sleep, Peritoneal Dialysis International. 2007, 27: 647-650. |
|
Tse K.C., Yung S.S.Y., Tang S.C.W., Tam S., Lai K.N. and Chan D.T.M., Atorvastatin at conventional dose did not reduce C-reactive protein in patients on peritoneal dialysis, Journal of Nephrology. 2008, 21: 283. |
|
Yip T., Tse K.C., Lam M.F., Cheng S.W., Lui S.L., Tang S.C.W., Ng M.M.T., Chan D.T.M., Lai K.N. and Lo W.K., Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients, Peritoneal Dialysis International. 2007, 27: 560-564. |
|
Researcher
: Tang SM |
|
List of Research Outputs |
|
Tang S.M. and Epstein R., A structural split in the human genome, PLoS ONE. 2007, 2(7): e603. |
|
Tang
S.M. and Epstein
R., Divergent roles of intron size and intron number in genetic
evolution. , The Sixth Asia-Pacific Bioinformatics Conference, |
|
Researcher
: Tang SM |
|
List of Research Outputs |
|
Tang S.M. and Epstein R., A structural split in the human genome, PLoS ONE. 2007, 2(7): e603. |
|
Tang
S.M. and Epstein
R., Divergent roles of intron size and intron number in genetic
evolution. , The Sixth Asia-Pacific Bioinformatics Conference, |
|
Researcher
: Tao R |
|
List of Research Outputs |
|
Tao R., Lau C.P., Lee H.C. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cell proliferation through the modulation of spontaneous Ca2+ oscillations. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 295. |
|
Tao R., Lau C.P. and Li G.R., Cyclic ADP-ribose increases human mesenchymal stem cells proliferation through modulation of spontaneous Ca2+ oscillation, 13th Medical Research Conference, LKS Faculty of Medicine, HKU. 2008. |
|
Tao R., Lau C.P., Tse H.F. and Li G.R., Functional Ion Channels in Mouse Bone Marrow Mesenchymal Stem Cells. , Am J Physiol Cell Physiol. 2007, 293(5): C1561-7. |
|
Researcher
: Tong SM |
|
List of Research Outputs |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Researcher
: Tsang KWT |
|
Project Title: |
Could gastro-oesphageal reflux be a cause of continued airway damage in bronchiectasis? |
|
Investigator(s): |
Tsang KWT |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2002 |
|
Abstract: |
|
The study is to determine the prevalence and severity of gastro-oesophageal reflux (GOR) in patients with bronchiectasis, the relationship of GOR with airway inflammation parameters, and identify clinical an dother parameters which predict the presence of GOR in patients with bronchiectasis with and without upper abdominal symptoms. |
|
List of Research Outputs |
|
Ho P.L., Poon W.W.N., Loke S.L., Leung M.S.T., Chow K.H., Wong R.C.W., Yip K.S., Lai E.L.Y. and Tsang K.W.T., Community emergence of CTX-M type extended-spectrum beta-lactamases among urinary Escherichia coli from women. , Journal of Antimicrobial Chemotherarpy. 2007, 60(1): 140-144. |
|
Researcher
: Tsang RCW |
|
List of Research Outputs |
|
Lui
S.L., Tsang R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the
severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Yung
S.S.Y., Tsang R.C.W., Chen
X.R. and Chan D.T.M., Heparin
ameliorates peritoneal dialysate-induced reduction of perlecan synthesis and
cellular transdifferentiation in human peritoneal mesothelial cells, Journal
of the American Society of Nephrology. 2007, 18: |
|
Researcher
: Tsang SWY |
|
List of Research Outputs |
|
Tsang S.W.Y., Kung A.W.C., Kanis J.A., Johansson H. and Oden A., Application of WHO fracture prediction algorithm to estimate the 10-year osteoporotic fracture probability in Hong Kong southern Chinese, 9th Regional Osteoporosis Conference, Osteoporosis Society of Hong Kong, Hong Kong, May 17-18. 2008. |
|
Researcher
: Tsang WL |
|
List of Research Outputs |
|
Guo H., Leung J.C.K., Lam M.F., Chan Y.Y., Tsang W.L., Lan H.Y. and Lai K.N., Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis., Journal of American Society of Nephrology. 2007, 18: 2689-2703. |
|
Guo H., Leung J.C.K., Chan Y.Y., Tsang W.L., Lam M.F., Lan H.Y. and Lai K.N., Ultrasound-contrast agent mediated naked gene delivery into the peritoneal cavity in adult rat, Gene Therapy. 2007, 14: 1712-1720. |
|
Researcher
: Tse EWC |
|
Project Title: |
The role of LIM-only protein, LM04, in the pathogenesis of sporadic ovarian cancer in Chinese |
|
Investigator(s): |
Tse EWC, Kwong YL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To assess the level of expression of LMO |
|
Project Title: |
Characterization of the interaction between Pin1 and HBx in human hepatocellular carcinoma |
|
Investigator(s): |
Tse EWC, Wong KB |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To characterize the interaction between Pin1 and HBx; to investigate the role of this interaction in the pathogenesis of HCC; to understand the structural basis of this interaction. |
|
List of Research Outputs |
|
Au W.Y., Leung A.Y.H., Tse E.W.C., Cheung W.W., Shek T.W.H. and Kwong Y.L., High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients, Leukemia Research. 2007, 32(4): 547-551. |
|
Pang R.W.C., Kwong Y.L. and Tse E.W.C., Pin1-HBx interaction: a step toward understanding the significance of hepatitis B virus genotypes in hepatocarcinogenesis., Gastroenterology. Elsevier, 2007, 133(2): 728-729. |
|
Tse E.W.C., Editorial Board Member, The Open Gastroenterology Journal. 2008. |
|
Tse E.W.C., Cheung J.C.W., Pang A.W.K., Au W.Y., Leung A.Y.H., Lam C.C.K. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia, Leukemia. 2007, 21(10): 2225-2226. |
|
Tse E.W.C., Molecular basis for arsenic as an anti-cancer agent, Croucher Foundation Conference: Stem Cells in Leukaemia and Lymphoma. 2008. |
|
Tse E.W.C., Stem cells in leukemia and lymphoma, hong kong, "Molecular basis for arsenic as an anti-cancer agent" at Croucher Foundation Conference. HK, 2008. |
|
Researcher
: Tse EYY |
|
List of Research Outputs |
|
Chen J.Y., Tse E.Y.Y., Lam T.P., Li D.K.T., Chao D.V.K. and Kwan C.W., Doctors’ personal health care choices: a cross-sectional survey in a mixed public/private setting, BMC Public Health. 2008, 8. |
|
Lam
T.P., Lam K.F. and Tse E.Y.Y., The preferred mode of
teaching and examination of primary care doctors undertaking postgraduate
diploma studies in Hong Kong., Hong Kong Practitioner . Hong Kong, The
|
|
Wun Y.T., Tse E.Y.Y., Lam T.P. and Lam C.L.K., PBL Curriculum Improves Medical Students' Participation in Small-group Tutorials., Medical Teachers. 2007, 29: e198 - e203 (I.F. 1.229). |
|
Researcher
: Tse HF |
|
Project Title: |
Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease |
|
Investigator(s): |
Tse HF, Lau CP, Kwong YL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
01/2004 |
|
Abstract: |
|
To determine the safety and efficacy of direct intramyocardial delivery of bone marrow cells using electromechanical guided injection; to investigate the angiogenic ability of implanting autologous bone marrow cells in patients with end-stage coronary artery disease. |
|
Project Title: |
Relationship between endothelial progenitor cells and markers of thrombogenesis and platelet activation in atrial fibrillation |
|
Investigator(s): |
Tse HF, Lip GYH, Lau CP, Kwong YL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
We hypothesise a relationship between the numbers of circulating EPCs and the markers of coagulation, platelet activiation and inflammation in patients with AF; we hypothesis that the numbers of circulating EPCs and vascular endothelial function predicts the outcome of cardioversion for AF. |
|
Project Title: |
Hypoxia-mediated differentiation of murine and human embryonic stem cells into cardiomyocytes: mechanistic roles of calcium and ion channels |
|
Investigator(s): |
Tse HF, Li RA, Fung ML, Wong TM, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The main objectives of this project are:
1/ To determine whether hypoxia is a critical physiological stimulus for the
differentiation of CMCs 2/ To determine the role of calcium and its key
regulatory protein RyR |
|
Project Title: |
Relationship between Endothelial Progenitor Cells and Initiation, Progression and Clinical Manifestation of Atherosclerosis |
|
Investigator(s): |
Tse HF, Lau CP, Kwong YL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Background: - Cardiovascular risk factors, such as hypertension and smoking, induce endothelial injury and inflammatory response, leading to formation of atherosclerotic lesions. The erosion and rupture of atherosclerotic plaque cause myocardial infarction, sudden cardoiac death and stroke. - Endothelial dysfunction and cell loss are prominent features in atherosclerosis (1). Therefore, maintenance of endothelial integrity is critical for the prevention of athersclerotic diseases. - Endothelial progenitor cells (EPCs) originating from the bone marrow derived cells, which express a variety of endothelial cell markers (2), play a significant role in repair (re-endothelialization) of injured blood vessels (3-5) and neovascularization of ischemic tissues (6-8). - Recent clinical studies demonstrated that cardiovacular risk factors are associated with reduced levels of circulating EPC (9), and the functional integrity of the endothelium correlated with the activities of EPCs (10). - Furthermore, continuous endothelial depletion or exhaustion of a presumed finite supply of EPC in patients with chronic diseases may reduce the number of circulating EPC. Indeed, in patients with chronic diseases, such as heart failure or diabetes, the number of EPC decreased and their function were impaired (9). - Circulating EPC provide an endogenous repair mechanism to counteract ongoing endothelial injury induced by atherosclerotic risk factor and to replace dysfunctional endothelium to prevent the progression of atherosclerosis. - On the other hand, the level of circulating mature endothelial cells may reflect the degree of ongoing endothelium loss from the damage vasculture. - Therefore, detection and quantification of circulating EPCs and mature endothelial cells may provide a novel marker for vascular function in patients with cardiovascular diseases. Whether this novel index of EPCs count reflects the atherosclerotic burden remains not clear. Objective: The aim of this study are - to investigate whether the ratio of the levels of circulating EPCs versus the level of circulating endothlial cells correlate with the amount of atherosclerotic burdens. - to evulate the interaction between atherosclerotic burden and systemic platelet and coagulation activation and inflammation in patients with cardiovascular diseases. References: 1. Drexler H, et al. J Mol Cell Cardiol. 1999;31:51-60. 2. Peichev M, et al. Blood 2000;95:952-8. 3. Kong D, et al. Circulation 2004;110:2039-46. 4. Fuujiyama S, et al. Circ Res. 2003;93:980-9. 5. Werner N, et al. Circ Res. 2003;93:e17-24. 6. Raffi S, et al. Nat Med 2003;9:702-12. 7. Takahashi T, et al. Nat Med. 1999;5:434-8. 8. Dzau VJ, et al. Hypertension 2005/46:7-18. 9. Vasa M, et al. Circ Res 2001;89:e1-7. 10. Hill JM, et al. N Engl J Med 2003;348:593-600. |
|
Project Title: |
Embryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling |
|
Investigator(s): |
Tse HF, Li GR, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To determine whether the differentiation status of embryonic stem cells is important in salvaging heart function in chronic heart failure; to determine whether the timing of embryonic stem cell transplantation is important in salvaging heart function in chronic heart failure. |
|
Project Title: |
Genetic enrichment of cardiac derivatives from human embryonic stem cells and their bioengineering for cell-based heart therapies |
|
Investigator(s): |
Tse HF, Li RA, Lau CP |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To generate genetically-engineered nESC lines whose heart derivatives are selectively labeled with a fluorescent protein (e.g. GEP) using lentivirus-mediated gene transfer techniques, followed by FACS-sorted purification; to genetically engineer the electrical phenotypes of nESC-derived CMs by delivering specific normal or engineered ion channel genes in a cardiac-specific manner via lentivirus-mediated gene transfer (for subsequent transplantation); to characterize the gene expression profiles of the FACS-purified nESC-derived CMs at both the transcriptional and translational levels using oligonucleotide array analysis, then compare and contrast to those of mESCs to reveal any species similarities and differences so as to better understand the poorly-studied process of human cardiogenesis. |
|
List of Research Outputs |
|
Au K.W., Siu D.C.W., Lau C.P., Tse H.F. and Li R.A., Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions, American Journal of Physiology Cellular Physiology . 2007, 294(1): C136-144. |
|
Chen W.H., Cheng X., Lee P.Y., Ng W., Kwok J.Y., Tse H.F. and Lau C.P., Aspirin resistance and adverse clinical events in patients with coronary artery disease., Am J Med. 2007, 120(7): 631-5. |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Lau C.P., Tse H.F. and Zhang X., 频率适应性起搏, 中华心律失常学杂志, 2007, 10. |
|
Lau C.P., Zhang X., Miao L. and Tse H.F., 频率适应性起搏, In: 陈新, 临床心律失常学-电生理和治疗, 北京, 人民卫生出版社, 2007. |
|
Lau
G.K.K., Chan Y.H., Yiu K.H.,
Tam S., Li S.W., Lau C.P. and Tse H.F., Incremental predictive
value of vascular assessments with |
|
Lee M.Y.K., Tse H.F., Zhu S., Man R.Y.K. and Vanhoutte P.M.G.R., Genomic changes in regenerated porcine coronary arterial endothelial cells , Arterioscler Thromb Vasc Biol. 2007, 27: 2443-2449. |
|
Li G.R., Wang H.B., Qin G.W., Jin M.W., Tang Q., Sun H., Du X.L., Deng X., Zhang X.H., Chen J., Chen L., Xu X.H., Cheng L.C., Chiu S.W., Tse H.F., Vanhoutte P.M.G.R. and Lau C.P., Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs., Circulation. 2008, 117(19): 2449-57. |
|
Li
G.R., Jin M.W., Tang Q., Qin
G.W., Wang H.B., Zhang X.H., Tse H.F.
and Lau C.P., The natural compound
acacetin prolongs refractory period and prevents experimental atrial
fibrillation in anesthetized dogs. , Am J Coll Cardiol/ACC.08, |
|
Lim H.S., Lip G.Y. and Tse H.F., Implantable cardioverter defibrillator following acute myocardial infarction: the '48-hour' and '40-day' rule. , Europace. . 2008, 10: 536-9. |
|
Mok
T.M.Y., Fung P.C.W., Ooi C., Tse H.F., Wong Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
|
Moore J.C., Fu J., Chan Y.C., Lin D., Tran H., Tse H.F. and Li R.A., Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state, Biochem Biophys Res Commun. . 2008, 372($): 553-8. |
|
Rubboli A., Halperin J.L., Airaksinen K.E., Buerke M., Eeckhout E., Freedman S.B., Gershlick A.H., Schlitt A., Tse H.F. and Lip G.Y., Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation. , Ann Med. (in press). 2008. |
|
Shantsila E., Watson T., Tse H.F. and Lip G.Y., New insights on endothelial progenitor cell subpopulations and their angiogenic properties ( In press), J Am Coll Cardiol 2007. 2007. |
|
Shantsila E., Watson T., Tse H.F. and Lip G.Y., New insights on endothelial progenitor cell subpopulations and their angiogenic properties. , J Am Coll Cardiol . 2008, 51: 669-71. |
|
Siu D.C.W., Au K.W., Lau C.P., Tse H.F. and Li R.A., Dynamic Conformational changes of the P-S6 linker of the packemakers (HCN) Channels identified by sulfhydryl modification: Port-to-gate coupling model , Heart Rhythm . 2008, 5, No. 5 May Supplement. |
|
Siu D.C.W., Zhang X., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., Recurrence of Atrial Fibrillation in hyperthyroidism related atrial fibrillation: A matched case-control study., Heart Rhythm Society Scientific Meeting 2008. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Tao R., Lau C.P., Tse H.F. and Li G.R., Functional Ion Channels in Mouse Bone Marrow Mesenchymal Stem Cells. , Am J Physiol Cell Physiol. 2007, 293(5): C1561-7. |
|
Tse
H.F., Gene Therapy, ”How to Detect
Recurrences AF and how important of Asymptomatic AF?”Biological therapies for
cardiac arrhythmias””Patient Selection”, The 3rd Asia-Pacific AF
Symposium, |
|
Tse
H.F., " Stem Cell Therapy in
Cardiovascular Diseases”, Vascular Leaders |
|
Tse
H.F., Advances in Arrhythmia Management”, The
South China International Congress of Cardiology, |
|
Tse
H.F., Biological Therapies for Cardiac
Arrhythmias, |
|
Tse
H.F., Biological Therapy for Cardiac
Arrhythmia”, 4th |
|
Tse H.F., Thambar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohon J., Bastian B., Chan J.K., Lo G., Ho C.L., Parker A., Hauser T.H. and Lau C.P., Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease, American Heart Journal. 2007, 154(5): 982.e1-982.e6. |
|
Tse H.F., Koh S., Lau E., Yang M. and Park E.R.L.I.J.O.O.N., Do HF Patients with Chronotropic incompetence benefit from higher rate pacing during exercise? , Heart Rhythm . 2008, 5. NO. 5 May supplement. |
|
Tse
H.F., Elite Reviewer 2007 for the Journal of
the |
|
Tse
H.F. and Siu
D.C.W., Ground-breaking Paper of 2006 (one of three chosen) in American
Heart Association Annual Scientific Meeting 2007: “Bioartificial sinus node constructed
via in vivo gene transfer of an engineered pacemaker HCN channel reduces the
dependence on electronic pacemaker in a sick sinus syndrome model.
Circulation. |
|
Tse H.F., Late-breaking Basic Science (Stem Cells) Study of 2007 (one of five chosen) in American Heart Association Annual Scientific Meeting 2007: ”Genetically-driven Maturation of hESC-derived cardiomyocytes completely ablates post-transplantation arrhythmias” , 2007. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Tse H.F., Thambsar S., Kwong Y.L., Rowlings P., Bellamy G., McCrohn J., Thomas P., Bastian B., Chan J.K.F., Lo G., Ho C.L., Chan W.S., Kwong R.Y., Parker A., Hauser T., Chan J., Fong Y.T. and Lau C.P., Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases, European Heart Journal. 2007, 28: 2998-3005. |
|
Tse H.F., Remove Barriers to Your EP Practice Growth: Education of your referring physicians and your patients”, Heart Rhythm 2008. 2008. |
|
Tse
H.F., The Present and Future for
Biopacemaker” “New Implantable Devices for Heart Failure and Rhythm
Disorders”, |
|
Tse H.F., Kwok K.W., Siu D.C.W., Tang M.O., Ho W.Y. and Lau C.P., Ventricular Rate regularization with right ventricular septal pacing preserves left ventricular function and improves exercise capacity in patients with permanent atrial fibrillation , Heart Rhythm . 2008, 5,No. 5 May Supplement. |
|
Tse H.F., 至Fit男女, ICABLE. 2008. |
|
Wang
M.M., Tse H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in Inter-atrial
Dyssynchrony and Atrial Mechanical Function in Sick Sinus Syndrome with or
without Paroxysmal Atrial Fibrillation (Oral presentation), The American
Heart Assosiation Scientific Sessions |
|
Wang M.M., Lau C.P., Siu D.C.W., Lee K.L.F. and Tse H.F., Differential in inter-atrial dyssynchrony and atrial mechanical function in sick sinus syndrome with or without paroxysmal atrial fibrillation., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang M.M., Tse H.F., Siu D.C.W., Lee K.L.F. and Lau C.P., Improvement of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang
M.M., Siu D.C.W., Zhang X., Lau C.P. and Tse H.F., Is atrial dyssynchrony
important in sinus node disease with or without atrial fibrillation?, The
American Society of Echocardiography, |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
|
Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
|
Wang S., Tse H.F., Khong P.L. and Ooi C.G.C., High prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients, RSNA 93rd Scientific Assembly and Annual Meeting, Chicago, U.S.A., 25-30 November 2007. |
|
Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells in patients with type II diabetes. , Mol Nutr Food Res (in press). 2008. |
|
Wu E.X., Wu Y., Nicholls J.M., Liao S., Lau C.P. and Tse H.F., MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model, In: Wu EX, Magn Reson Med. . 58(4), 2007, 687-95. |
|
Yiu K.H. and Tse H.F., Hypertension and cardiac arrhythmias: A review of the epidemiology, pathophysiology and clinical implications. , J Hum Hypertens 2008 . 2008, 22: 380-8. |
|
Yiu K.H., Lau G.K.K., Lau C.P. and Tse H.F., A review of surrogate markers for atherosclerosis: flow mediated dilatation, carotid intima media thickness, pulse wave velocity and ankle brachial index. , Vasc Disease Prevention (in press). 2008. |
|
Zhan H., Tse H.F., |
|
Zhang X., Chen H., Siu D.C.W., Yiu K.H., Chan W.S., Lee K.L., Chan H.W., Lee S.W., Fu G.S., Lau C.P. and Tse H.F., New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function., Journal of Cardiovascular Electrophysiology. 2008, 19(2): 136-141. |
|
de Voogt W., van Hemel N., de Vusser P., Mairesse G.H., van Mechelen R., Koistinen J., van den B.O.S. .A., Roose I., Voitk J., Yli-Maryry S., Stockman D., EI Allaf D., Tse H.F. and Lau C.P., No evidence of automatic atrial overdrive pacing efficacy on reduction of paroxysmal atrial fibrillation, Europace . 2007, 9(9): 798-804. |
|
Researcher
: Tse TF |
|
List of Research Outputs |
|
Wu
W., Lau C.P., Tse T.F. and Li G.R., Epidermal growth factor
receptor kinase and human ether a-go-go gene potassium channels. , 3rd
International Symposium on health aging. The |
|
Researcher
: Tso AWK |
|
List of Research Outputs |
|
Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
|
Ong K.L., Tso A.W.K., Lam K.S.L. and Cheung B.M.Y., Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension, Hypertension. 2008, 51: 1142-8. |
|
Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
|
Tso A.W.K., Xu A., Chow W.S. and Lam K.S.L., Adipose tissue and the metabolic syndrome: focusing on adiponectin and several novel adipokines, Biomarkers in Medicine. 2008, 2: 239-52. |
|
Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72. |
|
Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
|
Researcher
: Tsui Y |
|
List of Research Outputs |
|
Ao Q., Wang A.J., Chen G.Q., Zuo H.C., Zhang X.F., Fung C.K., Tsui Y., Shum D.K.Y. and Chan Y.S., Fabrication and characterization of multi-channel chitosan nerve conduit and its potential application, Abstracts of Third International Symposium on Healthy Aging - Improving the Health of an Aging Population: 30. March 1-2. 2008. |
|
Shea G.K.H., Tsui Y., Chan Y.S. and Shum D.K.Y., Functional study of stem-cell-derived Schwann cells using an in-vitro dorsal root ganglia model. Abstracts of Third International Symposium on Healthy Aging, Improving the Health of an Aging Population. 2008, 17. |
|
Tsui Y., Shea G.K.H., Chan Y.S. and Shum D.K.Y., Schwann cells derived from bone marrow stromal cells – in vitro study with dorsal root ganglia and in vitro study with peripheral nerve conduits, Abstracts of Third International Symposium on Healthy Aging - Improving the Health of an Aging Population: 19. March 1-2. 2008. |
|
Researcher
: Wang AYM |
|
Project Title: |
Endothelial progenitor cells in renal failure patients and its modulation by treatment with the peroxisome proliferator-activated receptor-gamma agonist in relation to clinical atherosclerosis |
|
Investigator(s): |
Wang AYM, Lai KN |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To test the hypothesis that endothelial progenitor cells (EPCs) are reduced and show impaired angiogenic function and that contribute to endothelial dysfunction and atherosclerosis in chronic renal failure (CRF) patients; to test the hypothesis that the number and functional activity of EPCs increase with amelioration of uremia by dialysis and that correspond to an improvement in flow-mediated dilatation in CRF patients; to study the short-term and longer-term effects of treatment with the peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist on the proliferation and functional activity of EPCs in relation to endothelial dysfunction and progression of atherosclerosis in chronic renal failure patients. |
|
List of Research Outputs |
|
Wang A.Y.M. and Lai K.N., Use of cardiac biomarkers in end-stage renal disease, Journal of American Society of Nephrology. 2008, 19: 1643-52. |
|
Researcher
: Wang J |
|
List of Research Outputs |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Researcher
: Wang MM |
|
List of Research Outputs |
|
Wang
M.M., Tse
H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in Inter-atrial
Dyssynchrony and Atrial Mechanical Function in Sick Sinus Syndrome with or
without Paroxysmal Atrial Fibrillation (Oral presentation), The American
Heart Assosiation Scientific Sessions |
|
Wang M.M., Lau C.P., Siu D.C.W., Lee K.L.F. and Tse H.F., Differential in inter-atrial dyssynchrony and atrial mechanical function in sick sinus syndrome with or without paroxysmal atrial fibrillation., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang
M.M., Improvement of Left Ventricular
Diastolic Dyssynchrony and Function after Upgrade of Longstanding Right
Ventricular Apical to Septal Pacing, The 12th Asian-Pacific Congress on
Doppler & Echocardiography. Oct. 28-30, |
|
Wang M.M., Tse H.F., Siu D.C.W., Lee K.L.F. and Lau C.P., Improvement of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., The 3rd Asia-Pacific Atrial Fibrillation Symposium, Taiwan. October 18-20. 2007. |
|
Wang
M.M., Siu
D.C.W., Zhang X., Lau C.P. and Tse H.F., Is atrial dyssynchrony
important in sinus node disease with or without atrial fibrillation?, The
American Society of Echocardiography, |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
|
Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Researcher
: Wat NMS |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Cheung B.M.Y., Wat N.M.S., Tam S., Thomas G.N., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese, Clin Endocrinol (Oxf). 2008, 68: 730-7. |
|
Cheung B.M.Y., Wat N.M.S., Man Y.B., Tam S., Cheng C.H., Leung G.M., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2), Am J Hypertens. 2008, 21: 17-22. |
|
Lam
K.S.L., Wat N.M.S., Tso
A.W.K., Fong H.Y. and Xu A., Additive effects of adiponectin
and C-reactive protein in predicting the risk of type 2 diabetes: a 10-year
prospective study. , 43rd Annual Meeting of the EASD,17-21 September 2007,
|
|
Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
|
Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72. |
|
Wat N.M.S., Lam T.H., Janus E.D. and Lam K.S.L., Impaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the Hong Kong Chinese population: a 5-year prospective study, Hong Kong Medical Journal. 2008, 14 (Suppl 3): S20-S22. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
|
Yeung C.Y., Xu A., Cheung C.W.S., Wat N.M.S., Yau J.M.H., Fong H.Y., Chau M.T. and Lam K.S.L., Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology.. US, American Heart Association, 2007, 27: 1796-1802. |
|
Researcher
: Wong BCY |
|
Project Title: |
Effect of XAF1 gene on tumor growth in gastric and colon cancer |
|
Investigator(s): |
Wong BCY, Tu S |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To study the effect of XAF1 on tumor growth. |
|
Project Title: |
Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer |
|
Investigator(s): |
Wong BCY, Xia HHX |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To clarify the role of Bcl-2 family proteins in NSAID-induced apoptosis in vitro in this proposal using gastric cancer cell lines. |
|
Project Title: |
Helicobacter pylori infection and CpG island methylation in gastric carcinogenesis |
|
Investigator(s): |
Wong BCY, Epstein R, Chan AOO |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To investigate if CpG island methylation at E-cadherin, as well as other tumor suppressor genes, in normal human gastric mucosa can be reversed by eradicating H. pylori; to establish an animal model to study the regulatory mechnaism of CpG island methylation at E-cadherin in gastirc cancer cell lines by Helicobacter pylori and interleukin 1. |
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Project Title: |
Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis |
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Investigator(s): |
Wong BCY, Xia HHX |
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Department: |
Medicine |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To determine the differences in gastric epithelial proliferation and apoptosis as well as in the incidence of gastric precancerous and cancerous lesions between COX deficient mice and wild-type mice after long-term infection with H. pylori; to determine the effects of NSAIDs and specific COX2 inhibitors on gastric proliferation and apoptosis, and their potential role in the prevention of gastric precancerous and cancerous lesions in H. pylori infected Mongolian gerbils. |
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List of Research Outputs |
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Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
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Cheung T.K., Lam B., Ip M.S.M., Kung R., Ng C.Y.C. and Wong B.C.Y., Gastro-esophageal reflux disease negatively impacted on asthma control, quality of life and psychological status in Chinese asthma patients, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract. |
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Cheung T.K. and Wong B.C.Y., Gastro-oesophageal Reflux Disease In Asia : Birth Of A 'new' Disease? , Drugs. 2008, 68(4): 399-406. |
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Cheung T.K., Lim P.W. and Wong B.C.Y., Noncardiac Chest Pain-An Asia-Pacific Survey on the Role of the Cardiologist., J Clin Gastroenterol. . 2008, Epub ahead of print. |
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Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
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Cheung
T.K., Lim P.W. and Wong B.C.Y.,
The view of gastroenterologists on non-cardiac chest pain in |
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Cheung T.K. and Wong B.C.Y., Treatment Of Helicobacter Pylori And Prevention Of Gastric Cancer., J Dig Dis.. 2008, 9(1): 8-13. |
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Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
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Farrell G.C., Desmond P.V. and Wong B.C.Y., the Editors of Journal of Gastroenterology and Hepatology.Agent Orange: Your new look JGH (the improvements go deeper than the cover), J Gastroenterol Hepatol . 2007, 22(8): 1167-8. |
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Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
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Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
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Hui S.K., Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Funtional Study of a 9kDa a-heical Domain of BIR3-RING Linker Region in XIAP Protein by NMR Spectroscopy, Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E21. |
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Lam T.J., Wong B.C.Y., Mulder C.J., Pena A.S. and Hui W.M., Increasing Prevalence Of Advanced Colonic Polyps In Young Patients Undergoing Colonoscopy In A Referral Academic Hospital In Hong Kong., World J Gastroenterol . 2007, 13(28): 3873-7. |
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Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
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Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
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Liu E.S.L., Ye Y., Shin V.Y., Wu W.K., Wong B.C.Y. and Cho C.H., Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice., Cancer Invest.. 2007, 25(8): 750-7. |
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Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
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Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Ng
F.H., Wong S.Y., Lam K.F., Chang P.C.M., Lau Y.K., |
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Ng
F.H., Lam K.F., Wong S.Y., Chang P.C.M., Lau Y.K., Yuen W.C., |
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Pang R.W.C., Law W.L., Poon J.T.C., Fan J., Choi C.Y., Poon R.T.P. and Wong B.C.Y., Isolation and characterization of tumorigenic and metastatic cancer stem cells from human colorectal cancer, 13th Medical Research Conference, Department of Medicine, HKUHong Kong . 2008. |
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Pang R.W.C., Law W.L., Poon J.T.C., Fan J., Choi C.Y., Poon R.T.P. and Wong B.C.Y., Isolation and characterization of tumorigenic and metastatic cancer stem cells from human colorectal cancer, Inaugural William and Elizabeth Dabies Foundation Trust International Meeting. 2008. |
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Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
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Qiao
L., Li H.Y., Li Z., Zou B. and Wong B.C.Y., Gene expression profile
in colon cancer cells in response to troglitazone: impact of XIAP expression,
Digestive Disease Week, |
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Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
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Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
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Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
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Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
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Tse M.K., Wong B.C.Y. and Sze K.H., Biophysical Characterization of a 13kDa Structural Domain in XAF1 Protein , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-20. |
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Tse
M.K., Wong B.C.Y. and Sze K.H., Structural and Functional
Study of XIAP-Associated Factor 1 (XAF1) - Identification and
Characterization of a 13kDa Structural Domain , 16th Triennial Conference
for the International Society of Magnetic Resonance, |
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Tse M.K., Wong B.C.Y. and Sze K.H., Structural and function Stude of XIAP-Associated Flactor1 (SFA__P), International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A37. |
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Tulassay Z., Stolte M., Sjölund M., Engstrand L., Butruk E., Malfertheiner P., Dite P., Tchernev K., Wong B.C.Y., Gottlow M., Eklund S., Wrangstadh M. and Nagy P., Effect Of Esomeprazole Triple Therapy On Eradication Rates Of Helicobacter Pylori, Gastric Ulcer Healing And Prevention Of Relapse In Gastric Ulcer Patients., Eur J Gastroenterol Hepatol.. 2008, 20(6): 526-36. |
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Wong
B.C.Y., Advance in Helicobacter pylori
research, Endoscopy Festival on Gastroenterology Beijing 2007 and 9th
Digestive Endoscopy Conference of |
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Wong
B.C.Y. and Cheung
T.K., Approach to the patient with gastrointestinal and liver disease,
In: Wang JY, Wong BCY, Textbook of Internal Medicine.. |
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Wong B.C.Y., Aspirin and peptic ulcers, Apple Daily, 13 May. 2008, A16. |
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Wong B.C.Y., Associate Editor, since 2004, Digestive Disease Watch. 2008. |
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Wong B.C.Y., Associate Editor-in-chief, since 2002, Chinese Journal of Gastroenterology. 2008. |
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Wong B.C.Y., Associate Editor-in-chief, since 2007, Forum of Gastroenterology and Hepatology. 2008. |
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Wong
B.C.Y., Associate Editor, Textbook of
Internal Medicine. |
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Wong B.C.Y., Bile reflux and GERD, Apple Daily, 19 February . 2008, A14. |
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Wong
B.C.Y., Capsule endoscopy and double balloon
enteroscopy, Macau International Surgical Forum 2008, |
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Wong
B.C.Y., Chemoprevention of gastric cancer
with aspirin: from bench to bedside, UCLA visiting professor program
lecture, |
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Wong
B.C.Y., |
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Wong
B.C.Y., |
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Wong
B.C.Y., |
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Wong B.C.Y., ERCP complications, Apple Daily, 19 August . 2007, A2. |
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Wong B.C.Y., Early bird dinner and health, TV Baby of TVB Magazine, 30,June. 2008, 039. |
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Wong B.C.Y., Editor, since 2003, Journal of Gastroenterology and Hepatology. 2008. |
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Wong B.C.Y., Editorial Board, since 1999, Chinese Journal of Gastroenterology. 2008. |
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Wong B.C.Y., Editorial Board, since 1999, Journal of Clinical Oncology, Chinese edition. 2008. |
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Wong B.C.Y., Editorial Board, since 2000, Journal of Gastroenterology and Hepatology. 2008. |
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Wong B.C.Y., Editorial Board, since 2001, Digestive Endoscopy. 2008. |
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Wong B.C.Y., Editorial Board, since 2002, Journal of Digestive Diseases. 2008. |
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Wong B.C.Y., Editorial Board, since 2002, MIMS Gastroenterology Guide. 2008. |
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Wong B.C.Y., Editorial Board, since 2003, Modern Digestion and Intervention. 2008. |
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Wong B.C.Y., Editorial Board, since 2004, Alimentary Pharmacology and Therapeutics. 2008. |
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Wong B.C.Y., Editorial Board, since 2004, European Review for Medical and Pharmacological Sciences. 2008. |
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Wong B.C.Y., Editorial Board, since 2004, Gastrointestinal endoscopy. 2008. |
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Wong B.C.Y., Editorial Board, since 2004, World Journal of Gastroenterology. 2008. |
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Wong B.C.Y., Editorial Board, since 2005, Carcinogenesis. 2008. |
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Wong B.C.Y., Editorial Board, since 2007, Cancer Epidemiology, Biomarkers & Prevention. 2008. |
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Wong
B.C.Y., Editorial Board, since 2007, Frontiers
of Medicine in |
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Wong B.C.Y., Editorial Board, since 2007, Medical Progress. 2008. |
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Wong B.C.Y., Editorial Board, since 2008, Cancer Prevention Research. 2008. |
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Wong B.C.Y., Editorial Board, since 2008, Clinical Journal of Gastroenterology. 2008. |
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Wong B.C.Y., Editorial Board, since 2008, Clinical and Experimental Gastroenterology. 2008. |
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Wong B.C.Y., Editorial Board, since 2008, Therapeutic Advances in Gastroenterology. 2008. |
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Wong
B.C.Y., Emerging Issues in management of acid
related diseases, Astrazeneca Symposium, |
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Wong
B.C.Y., Eradication of H pylori for gastric
cancer prevention., Proceedings of Cross Straits Digestive Forum, |
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Wong
B.C.Y., Eradication of H pylori: is it
necessary for gastric cancer prevention?, Proceedings of Asian Pacific
Digestive Week, |
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Wong
B.C.Y., Eradication of H. pylori for gastric
cancer prevention, Cross-Straits Digestive Forum, |
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Wong B.C.Y., Esophagitis management, Sing Pao, 15 August . 2007, A9. |
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Wong B.C.Y., Food poisoning, Oriental Daily, 10 August. 2007, A4. |
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Wong B.C.Y., Functional GI diseases, Ming Pao Daily, 14 Sept. 2007, A23. |
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Wong B.C.Y., GERD and cardiac pain, Medical Tribune, March 2008. 2008, V. |
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Wong B.C.Y., GERD and non cardiac chest pain, Mingpao, 2 August . 2007, A20. |
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Wong B.C.Y., GERD and vocal cord polyps, TVB Pleasure and Leisure 1:15pm- 2:00pm, March 10. 2008. |
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Wong
B.C.Y., GERD in |
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Wong B.C.Y., GERD-related non cardiac chest pain as distressing as cardiac chest pain, Press conference, Faculty of Medicine, HKU, 7 Jan. 2008. |
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Wong B.C.Y., Gastroenteritis, Apple Daily, 12 March. 2008, A1. |
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Wong
B.C.Y., H. pylori eradication in the
prevention of gastric cancer, |
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Wong
B.C.Y., H. pylori eradication in the
prevention of gastric cancer, Proceedings, Sixth Annual AACR international
Conference: Frontiers in Cancer Prevention Research, |
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Wong
B.C.Y., H. pylori eradication in the
prevention of gastric cancer, Sixth Annual AACR international Conference:
Frontiers in Cancer Prevention Research, |
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Wong B.C.Y., Heartburn, Health Plus Magazine, February. 2008, 30-31. |
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Wong
B.C.Y., Helicobacter pylori and gastric
cancer, Asia Pacific Digestive Week 2007, |
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Wong
B.C.Y., Honorary Professor, The |
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Wong
B.C.Y., Human Intervention trials on
Helicobacter pylori and gastric cancer, Human Intervention trials on
Helicobacter pylori and gastric cancer. Proceedings of 66th Annual Meeting of
the Japanese Cancer Association, |
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Wong
B.C.Y., Human intervention trials on
Helicobacter pylori and gastric cancer, 66th Annual Meeting of Japanese
Cancer Association, |
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Wong
B.C.Y., Influenza, HHCKLA Buddhist Ma |
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Wong B.C.Y., Liver cirrhosis, Sun Daily, 25 July . 2007, S2. |
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Wong B.C.Y., Molecular targets of GI cancer, Frontiers in Biomedical Research, HKU 2007, 13 December. 2007. |
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Wong B.C.Y., Molecular targets of GI cancer, Proceedings, Frontiers in Biomedical Research, HKU . 2007, pp60-61. |
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Wong B.C.Y., Oyster and gastroenteritis, Sun Daily, 10 August . 2007, A1. |
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Wong B.C.Y., PPI failure for GERD management, Eisai Symposium, Ho Chi Minh, Vietnam, 11 July. 2007. |
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Wong B.C.Y., Prevalence of GERD in southeast Asian countries., Proceedings of Asian Pacific Digestive Week, Kobe, Japan, 15-18 October 2007.J Gastroenterol Hepatol 2007 Oct, Vol 22 Supp 2, pp A107.. 2007. |
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Wong
B.C.Y., Prevention of stomach and colon
cancer, Luncheon talk, Zonta Club of Hong Kong East, |
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Wong B.C.Y., Screening of digestive cancers, Next magazine, 20 Sept. 2007, 134-138. |
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Wong B.C.Y., Spice and peptic diseases, Mingpao, 1 Aug. 2007, A22. |
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Wong B.C.Y., Star Mentorship Program, HKU SPACE Alumni Association, 11 April . 2008. |
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Wong
B.C.Y., Stomach cancer: molecular targets for
prevention and treatment, Keystone Symposium on Frontiers in
Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection
and Therapy, October 14 - 19, |
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Wong B.C.Y., Targeted therapy in GI cancers., Proceedings of Annual scientific meeting of The Federation of Medical Societies of Hong Kong, Hong Kong, 20 October 2007.. 2007. |
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Wong
B.C.Y., Targeted therapy in gastrointestinal
cancers, Annual scientific meeting of The Federation of Medical Societies
of Hong Kong, |
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Wong
B.C.Y., The evidence base medicine for use of
PPI in patients with functional dyspepsia, |
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Wong B.C.Y., The role of Helicobater pylori eradication in the prevention of gastric cancer, In Symposium: New Concepts in Gastric Cancer, In Annual Meeting of the American Association for Cancer Research 2008, 12-16 April. 2008. |
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Wong
B.C.Y., The spectrum of GERD: chest pain or
more, Grand Round, Dept of Medicine, |
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Wong
B.C.Y., Treatment of Helicobacter pylori for
Prevention of gastric cancer, UCLA visiting professor program lecture, |
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Wong B.C.Y., Use of probiotics in GI diseases, HK Economic Times, 26 Jan. 2008, A16. |
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Wong
B.C.Y., Visiting Professor, |
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Wong
B.C.Y., Visiting Professor, |
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Yau T., Chan P., Chan Y., Wong B.C.Y., Liang R.H.S. and Epstein R., Review article: current management of metastatic colorectal cancer - the evolving impact of targeted drug therapies. , Aliment Pharmacol Ther. 2008, 27(11): 997-1005. |
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Yau T.C., Chan P., Chan R., Wong B.C.Y., Liang R.H.S. and Epstein R., Current management of metastatic colorectal cancer: the evolving impact of targeted drug therapies., Aliment Pharm Ther. 2008, 27: 997-1005. |
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Yee Y.K., Cheung T.K., Chan A.O.O., Yuen R.M.F. and Wong B.C.Y., Decreasing Trend Of
Esophageal Adenocarcinoma In |
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Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
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Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
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Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
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Zou B. and Wong B.C.Y., Do serrated adenomas have higher malignant potential than traditional adenomas? , J Gastroenterol Hepatol. . 2007, 22 (11): 1701–1703. |
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Zou
B., Yang Y., Zeng H., Wong L.W., Jiang S. and Wong B.C.Y., New function of Krit 1
and as a New Interactor of XAF |
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Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Researcher
: Wong BLW |
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List of Research Outputs |
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Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
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Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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Researcher
: Wong CY |
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List of Research Outputs |
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Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells in patients with type II diabetes. , Mol Nutr Food Res (in press). 2008. |
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Researcher
: Wong DKH |
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List of Research Outputs |
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Fung J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis, Liver International. 2008. |
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Fung J.Y.Y., Yuen R.M.F., Yuen J.C.H., Wong D.K.H. and Lai C.L., Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study. , Aliment Pharmacol Ther. 2007, 26: 377-382. |
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Fung
J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, Hepatology. 2007, 6(4):Suppl 1:: |
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Fung
J.Y.Y., Lai C.L., Fong D.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
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Fung J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management, American Journal of Gastroenterology. 2008, 103: 1421-1426. |
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Fung
J.Y.Y., Lai C.L., But D., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, Hepatology.
2007, 46(4):Suppl 1:: |
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Fung
J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and
cirrhosis in chronic hepatitis B: implications for treatment and management, The
58th Annual Meeting of the American Association of the Study of Liver
Diseases, Boston, USA. 2007, |
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Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT
and HBeAG status after stopping lamivudine in patients with HBeAg
seroconversion, Hepatology. 2007, 46(4):Suppl 1:: |
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Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT,
and HBeAg status after stopping lamivudine in patients with HBeAg
seroconversion, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
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Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S375. |
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Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S375. |
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Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B Virus Core-related Antigens as a Marker for Monitoring of Chronic Hepatitis B Infection, Journal of Clinical Microbiology. 2007, 45: 3942-3947. |
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Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B virus core-related antigens as a marker for monitoring of chronic hepatitis B infection., J Clin Microbiol . 2007, 45(12): 3942-7. |
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Wong
D.K.H., Lai
C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
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Wong
D.K.H., Presidential Poster of Distinction, The
58th Annual Meeting of the American Association for the Study of Liver
Diseases, |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yuan H.J., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E., Lai C.L. and Yuen R.M.F., Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B, J Infect . 2007, 54: 497-503. |
|
Yuen R.M.F., Fong D.Y.T., Wong D.K.H., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response, Hepatology. 2007, 46: 1695-1703. |
|
Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
|
Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels, Gut. 2008, 57(1): 98-102. |
|
Researcher
: Wong LC |
|
List of Research Outputs |
|
Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
|
Chu L.W., Tam S., Kung A.W.C., Lo S., Fan S., Wong L.C., Morley J.E. and Lam K.S.L., Serum total and bioavailable testosterone levels, central obestiy and muscle strength changes with aging in healthy Chinese men, Journal of American Geriatrics Society. 2008, 56(7): 1286-1291. |
|
Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
|
Researcher
: Wong LW |
|
List of Research Outputs |
|
Zou
B., Yang Y., Zeng H., Wong L.W., Jiang S. and Wong B.C.Y., New function of Krit 1 and
as a New Interactor of XAF |
|
Researcher
: Wong LYF |
|
Project Title: |
Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages |
|
Investigator(s): |
Wong LYF, Cheung BMY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To assess the involvement of |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Cheung R.V., Wong L.Y.F., Wat N.M.S., Tam S., Leung G.M., Cheng C.H., Woo J., Janus E.D., Lau C.P., Lam T.H. and Lam K.S.L., Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese, Clin Chem Lab Med. 2008, 46: 523-7. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32. |
|
Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45. |
|
Ong K.L., Cheung B.M.Y., Wong L.Y.F., Wat N.M.S., Tan K.C.B. and Lam K.S.L., Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004, Ann Epidemiol. 2008, 18: 222-9. |
|
Researcher
: Wong PC |
|
List of Research Outputs |
|
Leung S.K., Yew W.W., Wong P.C., Fong D.Y.T., Lau A.C. and Ip M.S.M., Lung function testing prediction equations: do they fit all?, Chest. 2008, 133: 1288-1289. |
|
Researcher
: Wong RWM |
|
List of Research Outputs |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Researcher
: Wong RWS |
|
List of Research Outputs |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis, Medical Research Conference. 2008. |
|
Mok T.M.Y., Cheung B.M.Y., Lo Y., Leung Y.H., Wong R.W.S. and Lau W.C.S., Elevated plasma adrenomedullin in patients with systemic sclerosis with pulmonary hypertension, Journal of rheumatology. 2007, 34: 2224-2229. |
|
Mok
T.M.Y., Fung P.C.W., Ooi C., Tse H.F., Wong Y.I.K., Lam Y.M., Wong R.W.S. and Lau W.C.S., Serum Nitric Oxide
Metabolites and Disease Activity in Patients with Systemic Sclerosis, Clinical
Rheumatology. |
|
Siu H.O., Yang W., Lau C.S., Chan T.M., Wong R.W.S., Wong W.H.S. and Lau Y.L., Association of a Haploytpe of IRF5 Gene with Systemic Lupus Erythematosus in Chinese, Journal of Rheumatology. 2008, 35(2): 360-362. |
|
Researcher
: Wong SY |
|
List of Research Outputs |
|
Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
|
Ng
F.H., Wong S.Y., Lam K.F., Chang P.C.M., Lau Y.K., |
|
Ng
F.H., Lam K.F., Wong S.Y., Chang P.C.M., Lau Y.K., Yuen W.C., |
|
Researcher
: Wong VKH |
|
List of Research Outputs |
|
Kung
A.W.C., Yates S.J. and Wong V.K.H., Changing epidemiology
of osteoporotic hip fracture rates in |
|
Researcher
: Wong W |
|
List of Research Outputs |
|
Wong W.,
Lam C.L.K. and Fong D.Y.T., A Randomized, Double Blind,
Placebo-controlled Clinical Trial of Chinese Herbal Medicine in the Treatment
of Acute Upper Respiratory Infections, 3rd
International Congress on Complementary Medicine Research. |
|
Wong W.
and Lam C.L.K., Chinese Patients'
Experience in Randomized Clinical Trail-A Comparison of Western Medicine and
Chinese Medicine Clinical Trials, 3rd International
Congress on Complementary Medicine Research. |
|
Wong W.
and Lam C.L.K., Chinese patients'
experience in clinical trial-A comparison of Western medicine and Chinese
medicine clinical trials, Postgraduate Symposium of the 2007 TWGHs Eddie
Wang Symposium on Integrated Chinese and Western Medicine. |
|
Wong W.
and Lam C.L.K., Did the Chinese
Quality of Life Instrument applicable to Western medicine health services in
Chinese population?, 2008 Asian Chinese Quality of Life Conference. |
|
Wong W., Lam C.L.K., Leung K.F. and Zhao L., Is the Content of the Chinese Quality of Life Instrument (ChQOL) Really Valid in the Context of Traditional Chinese Medicine in Hong Kong?, Complementary Therapies in Medicine . 2008. |
|
Wong W.,
Measuring health related quality of life in the context of Traditional
Chinese Medicine-The way forward?, 2008 Asian Chinese Quality of Life
Conference. |
|
Wong W.
and Lam C.L.K., Presentation award
from the scholarship of the |
|
Researcher
: Wong Y |
|
List of Research Outputs |
|
Shiu
W.M.S., Wong Y., Bucala R.
and Tan K.C.B., Glyoxidized
low-density lipoprotein upregulates soluble lectin-like oxidized ldl receptor |
|
Shiu W.M.S., Tan K.C.B., Huang Y. and Wong Y., Type 2 diabetes mellitus and endothelial lipase, Atherosclerosis . 2008, 198: 441-7. |
|
Tam H.L., Shiu S.W.M., Chow W.S., Wong Y. and Tan K.C.B., Effect of atorvastatin on serum soluble receptor for advanced glycation end products in type 2 diabetes, Third International Symposium on Healthy Aging, Hong Kong. 2008. |
|
Tan K.C.B., Shiu S.W.M., Huang Y. and Wong Y., Effect of insulin on endothelial lipase in type 2 diabetes, The 7th International Diabetes Federation Western Pacific Region Congress, Wellington, New Zealand. 2008. |
|
Tan K.C.B., Zhou H., Shiu S.W.M. and Wong Y., Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus, American Diabetes Association 68th Scientific Sessions, San Francisco, USA. 2008. |
|
Zhou H., Tan K.C.B., Shiu W.M.S. and Wong Y., Increased serum advanced glycation end products is associated with impairment in HDL antioxidative capacity in diabetic nephropathy, Nephrol Dial Transplant. 2008, 23: 927-33. |
|
Researcher
: Wong YF |
|
List of Research Outputs |
|
Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print]. |
|
Researcher
: Wong YH |
|
List of Research Outputs |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Researcher
: Wu CH |
|
List of Research Outputs |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S375. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S375. |
|
Researcher
: Wu W |
|
List of Research Outputs |
|
Wu W., Lau C.P., Tse T.F. and Li G.R., Epidermal growth factor
receptor kinase and human ether a-go-go gene potassium channels. , 3rd
International Symposium on health aging. The |
|
List of Research Outputs |
|
Wun Y.T., Tse E.Y.Y., Lam T.P. and Lam C.L.K., PBL Curriculum Improves Medical Students' Participation in Small-group Tutorials., Medical Teachers. 2007, 29: e198 - e203 (I.F. 1.229). |
|
Researcher
: Xia HHX |
|
Project Title: |
Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study |
|
Investigator(s): |
Xia HHX, Wong BCY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To investigate the expression of gastric-related homeobox genes in human normal, precancerous and cancerous gastric tissues in vivo, and in non-malignant and malignant gastric cancer cell lines in vitro; to determine the effect of gastric-related homeobox genes on the secretion of gastric endocrine hormones. |
|
Project Title: |
Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis |
|
Investigator(s): |
Xia HHX, Wong BCY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2004 |
|
Abstract: |
|
To reveal the precise mechanism of COX and interrelationship between COX and H. pylori infection in the pathogenesis of gastric cancer; to provide insights into whether specific targets can be dealth with by new drugs, or a combination of drugs on different cellular targets to potentiate the chemoprevention effects; to develop effective strategies in the prevention of gastric cancer, for which no active agent or drug is available at present. |
|
Project Title: |
Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis |
|
Investigator(s): |
Xia HHX, Wong BCY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2005 |
|
Abstract: |
|
To determine the effect of MIF deficiency on H. pylori-induced inflammation and expression of inflammatory cytokines, cell proliferation and apoptosis and expression of related genes; to determine the difference in the incidence of gastric precancerous and cancerous lesions between MIF-knockout mice and wild-type mice after long-term infection with H. pylori. |
|
Project Title: |
Expression and
role of homeobox gene PDX |
|
Investigator(s): |
Xia HHX, Wong BCY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2006 |
|
Abstract: |
|
Homeobox genes encoding homeodomain
transcription factors are involved in establishing gradients of
differentiation during development of embryo and in maintaining these
patterns in adult tissue [1,2]. Dysregulation of homeobox gene expression in
cancer conforms to a simple rule: homeobox genes that are upregulated in
cancer are normally expressed during development and/or in undifferentiated
cells, whereas homeobox genes that are downregulated in cancer are normally
expressed in adulthood and/or in differentiated tissues [3]. For example, two
genes, CDX1 and CDX2, are normally expressed only in the intestine, and
downregulation of CDX1 and CDX2 expression is associated with colorectal
cancer. Pancreatic duodenal homeobox-1 protein (PDX-1), also known as IPF-1,
STF1, or IDX-1 is one transcription factor in the ParaHox gene family.
Generally, PDX1 gene is found normally in endocrine glands such as pancreatic
beta-cells, Brunner's glands of the duodenum, and pyloric glands of the
stomach [4,5]. PDX1 was confirmed to be a key regulator of pancreatic islet
development and insulin gene transcription in beta-cells [6]. Recently, the
association between PDX1 and gastric development is paid attention. Similar
to expression of CDX2, PDX1 which is found in gastric endocrine glands, may
be aberrantly expressed in hyperplasia, pancreatic or/and intestinal
metaplasia and even gastric cancer.However, few recent studies involving PDX1
and gastric precancerous and cancer lesions produced different results.
Whereas our previous study showed that, gastric expression of PDX1 was
down-regulated in H pylori infected gastric mucosa and intestinal metaplasia
with compared to normal mucosa [7], another recent study reported that PDX1
was frequently expressed in pseudopyloric glands and intestinal metaplasia
[8]. Moreover, the exact regulatory function of PDX1 gene in gastric
carcinogenesis is unknown.Purpose:1. To investigate the expression of PDX1
gene in human normal, precancerous and cancerous gastric tissues in vivo;2.
To investifgate the expression of PDX1 gene in non-malignant and malignant
gastric cancer cell lines in vitro. 3. To determine the effect of PDX1 gene
on the secretion of gastric endocrine cells since PDX1 has been implicated in
the regulation of G (gastrin-producing), D (somatostatin-producing) and EC
(serotonin producing) cells in gastric antral mucosa [9].Key issues and
problems addressed1. Whether PDX1 expression is dysregulaetd in gastric
carcinogenesis;2. Whether PDX1 plays an role in gastric
carcinogenesis.Reference1.Byrd JC, Yan P, Sternberg L, Yunker CK, Scheiman
JM, Bresalier RS. Gastroenterology 1997;113:455-64.2.Pitera JE, Smith VV,
Thorogood P, Milla PJ. Gastroenterology 1999;117:1339-51.3.Cory Abate-Shen.
Nature Reviews/Cancer.2002;2:777-785.4.Stoffers DA, Heller RS, Miller CP, et
al. Endocrinology 1999;140:5374-81.5.Larsson LI, Madsen OD, Serup P, et al.
Mech Dev 1996;60:175-84.6. Wang XP, Li Zh.J, Magnusson J, Brunicardi FC.
World J. Surg. 2005;29:334-338.7. Zhu S, Xia HHX., |
|
List of Research Outputs |
|
Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Researcher
: Xiao S |
|
List of Research Outputs |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese population., 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Annul Scientific Meeting, Hong Kong. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Multifactor Dimensionality Reduction Reveals Antagonistic Epistasis Between ESR1 and ESR2 with BMD Variation in Southern Chinese Women, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Researcher
: Xiao S |
|
List of Research Outputs |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese population., 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Epistasis analysis of estrogen receptor 1 and estrogen receptor 2 with BMD variation in southern Chinese women, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Annul Scientific Meeting, Hong Kong. 2007. |
|
Xiao S., Cheung C.L. and Kung A.W.C., Multifactor Dimensionality Reduction Reveals Antagonistic Epistasis Between ESR1 and ESR2 with BMD Variation in Southern Chinese Women, 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, 16-19 September 2007, Hawaii, USA. 2007. |
|
Researcher
: Xu A |
|
Project Title: |
Characterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin |
|
Investigator(s): |
Xu A, Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
The proposal seeks to address the following three questions: (1) how does adiponectin activate its receptors? (2) what are the membrane proximal down-stream signaling events of adiponectin receptors? how does adiponectin exert its anti-atherogenic actions via macrophage cells? |
|
Project Title: |
Angiopoitein-like protein 4 (ANGPTL4) as a novel therapeutic target for the treatment of insulin resistance and hyperglycemia |
|
Investigator(s): |
Xu A, Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2005 |
|
Abstract: |
|
To investigate the direct metabolic effects of angiopoietin-like protein 4 on liver and muscle, the two major organs involved in the regulation of systemic energy metabolism and insulin sensitivity; to elucidate the detailed metabolic pathways and signal transduction events that mediate the hypoglycemia and insulin-sensitizing effects of angiopoietin-like protein 4..; to study whether oligomerization and/or proteolysis plays a role in modulating the biological activities of angiopoietin-like protein 4. |
|
Project Title: |
The use of adiponectin as a biomarker to identify novel anti-diabetic and anti-atherogenic agents from Chinese herbs |
|
Investigator(s): |
Xu A, Qin GW, Lam KSL |
|
Department: |
Medicine |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To determine and optimize the chemical structures for the three bioactive compounds isolated from Rhizoma Dioscoreae and Radix Astragali; to study the molecular mechanisms by which the three bioactive compounds induce adiponectin production from fat cells; to explore the therapeutic potentials of the three bioactive compounds in the treatment of T2DM, endothelial dysfunction, atherosclerosis and other obesity-related metabolic disorders in several well-established animal models. |
|
Project Title: |
Inflammation in adipose tissue as a novel mechanism that link obesity with insulin reistance and type 2 diabetes |
|
Investigator(s): |
Xu A, Lam KSL, Chung SK |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
Obesity and its associated pathologies, including Type 2 Diabetes Mellitus (T2DM) and atherosclerosis, are chronic inflammatory diseases, characterized by elevated plasma concentrations of pro-inflammatory biomarkers, such as C-reactive proteins, TNF alpha and interleulin (IL) 6 (Bouloumie, Curat et al. 2005). Recent studies have found that adipose tissue (fat) is the predominant site that contributes to obesity-associated systemic inflammation and metabolic disorders (Wellen and Hotamisligil 2005). Macrophage infiltration and up-regulation of the inflammation-related genes in obese adipose tissue occur at the early phase of obesity and precede the development of insulin resistance (Xu, Barnes et al. 2003). It is suggested that activated macrophages in obese adipose tissue, in concert with the enlarged adipocytes, secrete a variety of pro-inflammatory adipokines/cytokines, which either act locally to perpetuate adipose tissue inflammation, or are released into the blood stream to induce systemic inflammation, insulin resistance and metabolic disorders in the periphery organs. Nevertheless, the mechanism responsible for triggering and perpetuating macrophage infiltration into obese adipose tissue remains poorly understood. It is also unclear whether inhibition of local inflammation in adipose tissue is sufficient to alleviate obesity-induced systemic inflammation and insulin resistance. Hypoxia inducible factor (HIF) 1alpha, a major transcription factor involved in the cellular response to hypoxia, has recently neen shown to be an important player in the inflammatory process (Paul, Simons et al. 2004). Studies in both human subjects and rodents have found that the expressions of HIF 1alpha in obese adipose tissue are substantially elevated (Trayhurn and Wood 2004; Cancello, Henegar et al. 2005). Weight loss, on the other hand, results in decreased expression of this transcription factor as well as reduced adipose tissue inflammation. Our in vitro studies showed that hypoxia, via induction of HIF 1alpha, could inhibit the production of the anti-inflammatory hormone adiponectin, but increase the expression of a cluster of pro-angiogenic and pro-inflammatory mediators from adipocytes, including leptin, VEGF, PAI-1 and IL6 (Chen, Wang et al.). In addition, we also demonstrated that HIF 1alpha activation could significantly enhance adipocyte-mediated adhesion and transmigration of human blood monocytes to/through the endothelial cells, the key step involved in macrophage tissue infiltration. Based on these evidences, we propose that HIF 1alpha plays a key role in initiating and/or maintaining chronic inflammation of adipose tissue and in triggering aberrant production of adipokines in obesity. As obesity develops, enlarged fat mass causes local micro-hypoxia and oxidative stress, both of which can induce HIF 1alpha accumulation and activation. Activated HIF 1alpha can decrease production of adiponectin and increase expression of macrophage attractants (such as leptin, VEGF, PAI-1, IL6, proteases and other chemokines). These changes can stimulate transport of monocytes to adipose tissue and promote adhesion and transmigration of monocytes to/through endothelial cells. Infiltrated monocytes in adipose tissue can be differentiated into macrophages by other locally produced inflammatory mediators. Activated macrophages in turn secrete a cluster of pro-inflammatory cytokines (such as IL1, TNFalpha and MCP1), which can act in a paracrine manner to induce further accumulation of HIF 1alpha in adipocytes, macrophage infiltration and aberrant production of adipokines. The macrophage-adipocyte interaction will perpetuate a viscous cycle that aggravates inflammatory responses in adipose tissue, and eventually induces systemic inflammation and insulin resistance. To test this hypothesis, the major objectives of this study are:1. To generate the transgenic mice with adipose tissue specific over-expression of dominant negative or constitutively active forms of HIF 1alpha; 2. To investigate the role of HIF 1alpha in obesity-induced macrophage infiltration and aberrant production of adipokines in adipose tissue, systemic inflammation and insulin resistance in the transgenic mouse models;3. To elucidate the molecular mechanisms by which HIF 1alpha induces endothelial cell activation and monocyte recruitment in adipose tissue; 4. To evaluate whether berberine, a compound with potent HIF 1alpha inhibitor activity, has therapeutic effects on obesity-associated chronic inflammation, insulin resistance and other metabolic abnormalities in mice. |
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Project Title: |
Hypoxia inducible factor 1α as a mediator of obesity-induced chronic inflammation, aberrant production of adipokines, and insulin resistance |
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Investigator(s): |
Xu A, Lam KSL, Chung SK |
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Department: |
Medicine |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2007 |
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Abstract: |
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To generate the transgenic mice with adipose tissue specific over-expression of the dominant negative form of HIF 1α to investigate the role of HIF 1α in obesity-induced macrophage infiltration and aberrant production of adipokines in adipose tissue, systemic inflammation and insulin resistance in the transgenic mouse models; to evaluate whether berberine, a compound with potent HIF 1α inhibitor activity, has therapeutic effects on obesity-associated chronic inflammation, insulin resistance and other metabolic abnormalities in mice. |
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Project Title: |
Endoplasmic reticulum (ER) stress alleviators as the novel therapeutic agents for treatment of obesity-related metabolic diseases |
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Investigator(s): |
Xu A, Lam KSL, Hoo RLC, Wang Y |
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Department: |
Medicine |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
05/2007 |
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Abstract: |
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The dramatic increase in the incidence of obesity becomes a major public health concern worldwide. Obesity is the main risk factor for a cluster of inter-related metabolic and cardiovascular diseases, including insulin resistance, dyslipidemia, type 2 diabetes, non-alcoholic steatohepatitis (NASH), hypertension and coronary heart diseases, which are the major contributors to the mortality and morbidity in our aging population. Although the detailed mechanisms that link obesity with its associated pathologies is not fully understood, growing evidence suggest that chronic inflammation within adipose tissue is a key culprit (1,2). Both clinical and experimental studies have demonstrated that obese adipose tissue is characterized by increased macrophage infiltration and activation of the inflammatory pathways, such c-Jun NH2-terminal kinase (JNK) and NF-kB (3-5). The number of macrophages present in adipose tissue is closely correlated with adiposity and adipocyte size in both humans and animal models (4). Notably, inflammation in adipose tissue preceded the development of hyperinsulinemia in high fat diet-induced obese mice, suggesting that adipose inflammation is causally linked with systemic insulin resistance (3). The causal link between inflammation of adipose tissue and insulin resistance is also supported by the findings that weight reduction and anti-inflammatory drugs can reduce adipose macrophage infiltration and currently improve systemic insulin sensitivity (3,6). Adipose tissue is a major endocrine organ that secretes a wide spectrum of bioactive molecules (such as adipokines, cytokines and acute phase proteins) into the blood stream (7). Some of the “good” adipokines, such as adiponectin, visfatin and recently characterized vaspin, can increase insulin sensitivity, improve glucose tolerance and vascular reactivity. We and others have demonstrated that adiponectin possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory activities, and also protects against obesity-associated nonalcoholic fatty liver diseases (8-10). On the other hand, “noxious” adipokines and cytokines, such as TNFa, PAI-1, resistin, adipocyte-fatty acid binding protein (A-FABP) and lipocalin-2, possesses adverse effects. As obesity develops, macrophage infiltration and interactions between macrophages and adipocytes cause abnormal production of these secretory proteins from adipose tissue, such as decreased adiponectin and increased TNFa, lipocalin-2, A-FABP, IL6 and PAI-1 (1,2). Discordant production of adipokines/cytokines from inflamed adipose tissue is a central mediator in the pathogenesis of obesity-related insulin resistance and metabolic abnormalities. Endoplasmic reticulum (ER) stress has recently been shown to play a central role in triggering inflammation in obese adipose tissue (11,12). The ER is a critical organelle where all secreted and transmembrane proteins are synthesized, folded into their correct three-dimensional structures, posttranslationally modified, and transported to their final cellular destinations. Pathological conditions, such as nutrient overloads, viral infections, hypoxia and metabolic stress, cause the accumulation of misfolded or unfolded proteins in the ER lumen which known as ER stress. The unfolded protein response (UPR) is the mechanism to alleviate ER stress by activating the synthesis of proteins that can facilitate folding of protein in ER lumen. On the other hand, ER stress can induce activation of several major inflammatory pathways, including JNK and NF-kB (11). In both dietary and genetic animal models of obesity, the biochemical parameters of ER stress were detected in both adipose tissue and liver (12). Transgenic studies have demonstrated that the ER stress responses might be responsible for activation of the JNK inflammatory pathway in obese adipose tissue and causation of obesity-linked insulin resistance (12), suggesting that alleviation of ER stress may offer novel therapeutic or preventive strategies for obesity-related metabolic diseases, especially type 2 diabetes. Indeed, a latest study published in Science has identified two small chemical compounds (4-phenyl butyric acid (PBA) and taurine-conjugated ursodeoxycholic acid (TUDCA)) that can alleviate the ER stress in cells and whole animals(13). Remarkably, oral administration of PBA or TUDCA into obese and diabetic mice leads to the normalization of hyperglycemia, restoration of the systemic insulin sensitivity and resolution of fatty liver disease within 4 days after treatment (13). This exciting finding suggests that ER chemical chaperones, such as PBA and TUDCA, represent a novel class of drugs for the treatment of obesity-related disorders. In this study, we will further explore the therapeutic potentials of these two ER chemical chaperones (PBA and TUDCA), and investigate the detailed cellular mechanisms underlying the therapeutic actions of PBA and TUDCA. Our specific objectives are: 1. To evaluate the therapeutic effects of PBA and TUDCA in both dietary and genetic obese mouse models, with particular focus on their roles in alleviation of adipose tissue inflammation; 2. To comprehensively analyze the effects of PBA and TUDCA on circulating levels of adipokines, cytokines and metabolic hormones using antibody suspension array-based multiplex immunoassays. 3. To elucidate the cellular pathways by which the two ER chemical chaperones (PBA and TUDCA) increase insulin sensitivity in liver and muscle tissues. PLEASE REFER TO SECTION VII for the references cited. |
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List of Research Outputs |
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Chow W.S., Hoo R.L.C., Yau M.H., Xu A., Tse H.F., Tso A.W.K., Fong H.Y., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on PAI-1 production, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
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Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis , 13 th Medical Research Conference, The University of Hong Kong. 2008. |
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Hoo R.L.C., Cheng K.Y., Xu A. and Lam K.S.L., Adipocyte-fatty acid binding protein (A-FABP) as a novel player in the pathogenesis of non-alcoholic steatohepatitis, 13th Medical Research Conference, HKU, 19 Jan 2008, Hong Kong. 2008. |
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Hoo R.L.C., Chow W.S., Yau J.M.H., Xu A., Tso A.W.K., Tse H.F., Fong C.H., Tam S., Chan L. and Lam K.S.L., Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production, Arterioscler Thromb Vasc Biol. 2007, 27: 2777-82. |
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Hoo R.L.C., Yeung C.Y., Lam K.S.L. and Xu A., Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid binding protein, In: Future drugs Ltd, Expert Rev. Endocrinol. Metab.. 2008, 3: 29-41. |
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Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
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Krause M...P..., Liu Y..., Vu V., Chan L., Xu A., Riddle M...C..., Sweeney G. and Hawke T...G..., Adiponectin is Expressed by Skeletal Muscle Fibers and Influences Muscle Phenotype and Function., Am J Physiol Cell Physiol. 2008, 295: C203-12. |
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Lam
K.S.L., Wat N.M.S., Tso A.W.K., Fong H.Y. and Xu A., Additive effects of
adiponectin and C-reactive protein in predicting the risk of type 2 diabetes:
a 10-year prospective study. , 43rd Annual Meeting of the EASD,17-21
September 2007, |
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Lau
T.Y.I., Ye H.Y., Xu A. and
Lam K.S.L., Macrophage-adipocyte
cross-talk in the initiation of obesity-related insulin resistance and type
2diabetes. , 43rd Annual Meeting of the EASD, 17-21 September 2007, |
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Liu L., Wang Y., Lam K.S.L. and Xu A., Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications, Endocr Metab Immune Disord Drug Targets (Invited review). 2008, 8: 89-98. |
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Lui M.M.S., Lam J.C.M., Mak H.K.F., Xu A., Ooi C.G.C., Lam D.C.L., Mak J.C.W., Khong P.L. and Ip M.S.M., C-reactive protein is associated with sleep disordered breathing independent of obesity, American Thoracic Society International Conference, Toronto, Canada, American Thoracic Society Program and Abstracts. 2008, pA481. |
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Palanivel R., Eguchi M., Liu Y., Wang Y., Xu A. and Sweeney G., Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. , Cardiovasc Res. . 2007, 75: 148-57. |
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Palanivel R., Fang X., Park M., Eguchi M., Pallan S., De Girolamo S., Liu Y., Wang Y., Xu A. and Sweeney G., Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes., Cardiovascular Research. 2007, 75: 148-57. |
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Tan K.C.B., Chow W.S., Tso A.W.K., Xu A., Tse H.F., Hoo R.L.C., Betteridge D.J. and Lam K.S.L., Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes, Diabetologia. 2007, 50: 1819-25. |
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Tso A.W.K., Xu A., Chow W.S. and Lam K.S.L., Adipose tissue and the metabolic syndrome: focusing on adiponectin and several novel adipokines, Biomarkers in Medicine. 2008, 2: 239-52. |
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Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72. |
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Vu V., Kim W., Fang X., Liu Y.T., Xu A. and Sweeney G., Coculture with primary visceral rat adipocytes from control but not streptozotocin-induced diabetic animals increases glucose uptake in rat skeletal muscle cells: role of adiponectin, Endocrinology. 2007, 148: 4411-9. |
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Wang Y., Lam K.S.L. and Xu A., Post-translational modifications of adiponectin: mechanisms and functional implications. , Biochemical Journal. 2008, 409: 623-33. |
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Xu
A., Adipocytokines as Biomarkers for
Obesity-related Diseases: From Risk Prediction to Therapeutic Intervention, 5th
Adipocytokine Research Symposium, |
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Xu A., As a member of editorial board, Journal of Diabetes. 2008. |
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Xu A., Rosiglitazone improves vascular dysfunction through inducing the production of high molecular weight oligomeric adiponectin in db/db diabetic mice, 3rd Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group. 2007. |
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Xu A., Vascular complications of obesity: role of novel adipokines, The fourth International Symposium on Diabetes and Immunology, Nanling. 2008. |
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Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
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Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
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Yeung C.Y., Xu A., Cheung C.W.S., Wat N.M.S., Yau J.M.H., Fong H.Y., Chau M.T. and Lam K.S.L., Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology.. US, American Heart Association, 2007, 27: 1796-1802. |
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Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
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Zhou
M., Wang Y., Lam K.S.L., Tam P.K.H., Hoo R.L.C., Liu J. and Xu A., Increased Vulnerability to
Liver Injury is Associated with Decreased Mitochondrial Activities in
Adiponectin Knockout Mice: Potential Roles of UCP |
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Zhu W., Cheng K.Y., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention, Clin Sci (London). 2008, 114: 361-74 (Invited Review). |
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Researcher
: Xu J |
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Project Title: |
Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese |
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Investigator(s): |
Xu J, Lam KSL, Sham PC |
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Department: |
Medicine |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2004 |
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Abstract: |
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To further study the extended MODYX families recruited from our previous project and screen for MODY loci in Southern Chinese, starting with MODY loci reported in other populations; to investigate whether there is overlap between MODY loci and reported T2DM loci in Chinese, based on studies with predilection of early onset T2DM diagnosed before 40 years of age. |
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Researcher
: Yam IYL |
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List of Research Outputs |
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Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
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Researcher
: Yam LYC |
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List of Research Outputs |
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Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L., Tang
K.S., Yam L.Y.C. and Chan M.M.W., Variability of the
prevalence of undiagnosed airflow obstruction in smokers using different
diagnostic criteria, 12th Congress of the Asian Pacific Society of
Respirology / 2nd Joint Congress of the Asian Pacific Society of Respirology/American
College of Chest Physicians, Queensland, Australia. Respirology. 2007, 12
(supp 4): A115 ( |
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Lau A.C.W., Ip M.S.M., Lai C.K.W., Choo K.L., Tang K.S., Yam L.Y.C. and Chan M.M.W., Variability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteria, Chest. 2008, 133: 42-48. |
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Researcher
: Yang F |
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List of Research Outputs |
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Yang F.,
Chung A.C.K., Lan X.R. and Lan H.Y., Angiotensin II Induces
Epithelial-Mesenchymal Transition (EMT) via the TGF-beta/Smad3-Dependent and
ERK/p38 MAP Kinase-Smad3 Crosstalk Pathways: Essential Role of Smad3, 13th
Medical Research Conference of Department of Medicine ( |
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Yang F.,
Chung A.C.K., Lan X.R. and Lan H.Y., Signaling Mechanisms of
Angiotensin II-Induced EMT in Tubular Epithelial Cells, The 12th Research
Postgraduate Symposium, HKU, 12- |
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Researcher
: Yang Y |
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List of Research Outputs |
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Zou
B., Yang Y., Zeng H., Wong L.W., Jiang S. and Wong B.C.Y., New function of Krit 1 and
as a New Interactor of XAF |
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Researcher
: Yates SJ |
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List of Research Outputs |
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Kung
A.W.C., Yates S.J. and Wong V.K.H., Changing epidemiology of
osteoporotic hip fracture rates in |
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Researcher
: Yeung CK |
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List of Research Outputs |
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Au W.Y., Yeung C.K., Cheung M.C. and Trendell-Smith N.J., Penile lichen sclerosus after allogeneic stem cell transplantation, British Journal of Dermatology. EPub, 2008. |
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Yu C.S., Yeung C.K., Shek S.Y.N., Tse R.K., Kono T... and Chan H.H.L., Combined infrared light and bipolar radiofrequency for skin tightening in Asians., Lasers in Surgery and Medicine. 2007, 39(6): 471-5. |
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Researcher
: Yeung CY |
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List of Research Outputs |
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Hoo R.L.C., Yeung C.Y., Lam K.S.L. and Xu A., Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid binding protein, In: Future drugs Ltd, Expert Rev. Endocrinol. Metab.. 2008, 3: 29-41. |
|
Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Wat N.M.S., Yau M.H., Zhang J., Fong H.Y., Chau M.T. and Lam K.S.L., Epidermal fatty acid-binding protein is a novel circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, 11 Nov 2007, Hong Kong. 2007. |
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Yeung C.Y., Xu A., Cheung C.W.S., Wat N.M.S., Yau J.M.H., Fong H.Y., Chau M.T. and Lam K.S.L., Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology.. US, American Heart Association, 2007, 27: 1796-1802. |
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Zhang X., Yeung C.Y., Karpisek M., Stejskal D., Zhou Z., Feng L., Wong L.C., Chow W.S., Tso A.W.K., Lam K.S.L. and Xu A., Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans, Diabetes. 2008, 57(5):1246-53. |
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Researcher
: Yeung JSL |
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List of Research Outputs |
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Ho Y.W., Yeung J.S.L., Chiu P.K.Y., Tang W.M., Lin Z.B., Man R.Y.K. and Lau W.C.S., Ganoderma lucidum polysaccharide peptide reduced the production of pro-inflammatory cytokines in activated rheumatoid synovial fibroblast, Molecular & Cellular Biochemistry. 2007, 301(1-2): 173-179. |
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List of Research Outputs |
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Chan K.H., Ho S.P., Yeung S.C., Cho C.H., Koo M.W.L., Lam W.K., Man R.Y.K. and Mak J.C.W., Effects of Lung Chen tea on antioxidant enzyme activity in rat lungs after exposure to cigarette smoke, Pro Am Thorac Soc. 2008, 3: A241. |
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Researcher
: Yew WW |
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List of Research Outputs |
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Leung S.K., Yew W.W., Wong P.C., Fong D.Y.T., Lau A.C. and Ip M.S.M., Lung function testing prediction equations: do they fit all?, Chest. 2008, 133: 1288-1289. |
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Mak
J.C.W., Ho S.P., Yu W.C., Choo
K.L., |
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Researcher
: Yik PY |
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List of Research Outputs |
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Chu L.W., Li Y., Tang A.Y.B., Cheung B.M.Y., Leung Y.H., Yik P.Y., Jin D. and Song Y., A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer' s disease in Chinese, Am J Med Genet B. 2007, 144(8): 1007-13. |
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Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98. |
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Researcher
: Young JLP |
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List of Research Outputs |
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Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
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Researcher
: Yu CS |
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List of Research Outputs |
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Yu C.S., Yeung C.K., Shek S.Y.N., Tse R.K., Kono T... and Chan H.H.L., Combined infrared light and bipolar radiofrequency for skin tightening in Asians., Lasers in Surgery and Medicine. 2007, 39(6): 471-5. |
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Researcher
: Yu YL |
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List of Research Outputs |
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Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., Neurology in Practice 4th edition , Hong Kong, Hong Kong University Press, 2008, In press. |
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Researcher
: Yuen JCH |
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List of Research Outputs |
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Fung J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis, Liver International. 2008. |
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Fung J.Y.Y., Yuen R.M.F., Yuen J.C.H., Wong D.K.H. and Lai C.L., Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study. , Aliment Pharmacol Ther. 2007, 26: 377-382. |
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Fung
J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, Hepatology. 2007, 6(4):Suppl 1:: |
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Fung
J.Y.Y., Lai C.L., Fong D.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
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Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT
and HBeAG status after stopping lamivudine in patients with HBeAg
seroconversion, Hepatology. 2007, 46(4):Suppl 1:: |
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Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA, ALT,
and HBeAg status after stopping lamivudine in patients with HBeAg
seroconversion, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
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Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale longitudinal
study of chronic hepatitis B patients with hepatitis B surface antigen
seroclearance, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
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Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
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Yuen R.M.F., Fong D.Y.T., Wong D.K.H., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response, Hepatology. 2007, 46: 1695-1703. |
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Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
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Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
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Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels, Gut. 2008, 57(1): 98-102. |
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Researcher
: Yuen RMF |
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List of Research Outputs |
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But D., Lai C.L. and Yuen R.M.F., Hepatitis virus related hepatocellular carcinoma., World J Gastroenterol. 2008, 14(11): 1652-1656. |
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But D.Y., Lai C.L. and Yuen R.M.F., Natural history of hepatitis-related hepatocellular carcinoma, World Journal of Gastroenterology. 2008, 14: 1652-6. |
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Chan
A.O.O., Jim M.H., Lam K.F., Morris J.S., Siu D.C.W., Tong T., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Szeto M.L., Wong B.C.Y. and Lam S.K., Prevalence of Colorectal
Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease, In:
Catherine D. DeAngelis, Journal of the American Medical Association.
|
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Chan P., Yuen R.M.F. and Lai C.L., Chemotherapy and radiotherapy for the treatment of hepatocellular carcinoma., In: In McCulloch P ed, Gastrointestinal Oncology: Evidence and analysis.. 2007, 309-316. |
|
Cheung T.K., Wong R.W.M., Wong Y.H., Chan C.K., Fung J.Y.Y., Yuen R.M.F., Chan A.O.O., Tong S.M. and Wong B.C.Y., Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese, Digestion. 2007, 75(2-3): 128-134. |
|
Fung J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis, Liver International. 2008. |
|
Fung J.Y.Y., But D.Y., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, S242. |
|
Fung J.Y.Y., But D., Hsu A., Cheng C.T.K., Hung I.F.N., Seto W.K., Wong B.C.Y., Lai C.L. and Yuen R.M.F., Increase in liver stiffness measurements in severe hepatitis B flares, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S242. |
|
Fung J.Y.Y., Yuen R.M.F., Yuen J.C.H., Wong D.K.H. and Lai C.L., Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study. , Aliment Pharmacol Ther. 2007, 26: 377-382. |
|
Fung
J.Y.Y., Lai C.L. and Yuen R.M.F., New paradigms for the
treatment of chronic hepatitis B, Journal
of Gastroenterology and Hepatology. 2008, 23( |
|
Fung
J.Y.Y., Lai C.L., Fong D.Y.T., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for fibrosis
and cirrhosis in chronic hepatitis B using liver stiffness measurement, Hepatology.
2007, 6(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., Fong D.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Predictive model for
fibrosis and cirrhosis in chronic hepatitis B using liver stiffness
measurement, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management, American Journal of Gastroenterology. 2008, 103: 1421-1426. |
|
Fung
J.Y.Y., Lai C.L., But D., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis
and cirrhosis in chronic hepatitis B: implications for treatment and
management, Hepatology. 2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., But D.Y., Wong D.K.H., Cheung T.K. and Yuen R.M.F., Prevalence of fibrosis
and cirrhosis in chronic hepatitis B: implications for treatment and
management, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA,
ALT and HBeAG status after stopping lamivudine in patients with HBeAg
seroconversion, Hepatology. 2007, 46(4):Suppl 1:: |
|
Fung
J.Y.Y., Lai C.L., Tanaka Y.,
Mizokami M., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA,
ALT, and HBeAg status after stopping lamivudine in patients with HBeAg
seroconversion, The 58th Annual Meeting of the American Association of the
Study of Liver Diseases, Boston, USA. 2007, |
|
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment of Chronic Hepatitis C with Different Genotypes, In: Emilio Jirrilo, Hepatitis C Virus Disease. Springer, 2007. |
|
Fung K.T.T., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Etiologies of chronic liver diseases in Hong Kong, Eur J Gastroen Hepat. 2007, 19(8): 659-64. |
|
Hung I.F.N., Poon R.T.P., Lai C.L., Fung J.Y.Y., Fan S.T. and Yuen R.M.F., Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection., American Journal of Gastroenterology. 2008, 103(7): 1663-1673. |
|
Lai C.L. and Yuen R.M.F., The natural history and treatment of CHB: critical evaluation of treatment criteria and endpoints, Ann Intern Med. 2007, 147(1): 58-61. |
|
Lai C.L. and Yuen R.M.F., The natural history of chronic hepatitis B., J Viral Hepatitis . 2007, 14 (Suppl 1): 6-10. |
|
Lai
C.L., Fung J.Y.Y. and Yuen R.M.F., Updates in the
Treatment of Chronic Hepatitis B., The |
|
Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Updates in the treatment of chronic hepatitis B, The Hong Kong Medical Diary. 2008, 13: 15-19. |
|
Lai C.L. and Yuen R.M.F., What is the best end point for hepatitis B treatment? , Ann Intern Med. 2008, 148: 560. |
|
Lam
T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., Leung G.M. and McGhee S.M., Health-related Quality of
Life of Patients with Chronic Hepatitis B Infection. Oral, 2008 Asian
Chinese Quality of Life Conference. |
|
Lam
T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics
of the Chinese (Hong Kong) version of the chronic liver disease
questionnaire. Poster, 2007 International Society for Quality of Life
Research Annual meeting. |
|
Lam T.P., Lam C.L.K., Leung G.M., McGhee S.M., Lai C.L., Yuen R.M.F. and Fong D.Y.T., Validity and psychometrics of the Chinese (Hong Kong) version of the chronic liver disease questionnaire, Quality of Life Research. 2007, A-48, Abstract #1472. |
|
Li G., Xia H.H.X., Chen M.H., Tsukamoto T., Tatematsu T., Gu Q., Qiao L., Cho C.H., So W.H., Yuen R.M.F., Hu P.J., Liang Y.J., Lin H.L., Chan A.O. and Wong B.C.Y., Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils, Helicobacter. 2008, 13: 20-9. |
|
Libbrecht E., Doutreloigne J., Van de Velde H., Yuen R.M.F. and Lai C.L., Evolution of Primary and Compensatory Lamivudine-Resistance Mutations during Long-term Lamivudine Treatment in Chronic HBV-Infected Patients Assessed by a Line Probe Assay., J Clin Microbiol. 2007, 45(12): 3935-41. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S375. |
|
Wong D.K.H., Yuen R.M.F., Fung J.Y.Y., Wu C.H. and Lai C.L., Decline of HBV covalently closed circular DNA during telbivudine and lamivudine therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S375. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B Virus Core-related Antigens as a Marker for Monitoring of Chronic Hepatitis B Infection, Journal of Clinical Microbiology. 2007, 45: 3942-3947. |
|
Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M., Fung J.Y.Y. and Yuen R.M.F., Hepatitis B virus core-related antigens as a marker for monitoring of chronic hepatitis B infection., J Clin Microbiol . 2007, 45(12): 3942-7. |
|
Wong
D.K.H., Lai C.L., Fung J.Y.Y., But D.Y., Hung I.F.N., Yuen J.C.H., Fung F.K.C., Young J.L.P. and Yuen R.M.F., Large scale
longitudinal study of chronic hepatitis B patients with hepatitis B surface
antigen seroclearance, The 58th Annual Meeting of the American Association
of the Study of Liver Diseases, Boston, USA. 2007, 46: |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy. 2008, 48: S250. |
|
Wong D.K.H., Lai C.L., Fung J.Y.Y., Lee C.K., Lin C.K., Hung I.F.N., But D., Hsu A., Chan P., Cheung T.K., Fung F.K.C., Yuen J.C.H., Young J.L.P., Ngai W.S. and Yuen R.M.F., Screening of occult HBV infection in blood donors in Hong Kong using nucleic acid testing, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl) 2: S250. |
|
Yee Y.K., Cheung T.K., Chan A.O.O., Yuen R.M.F. and Wong B.C.Y., Decreasing Trend Of
Esophageal Adenocarcinoma In |
|
Yee Y.K., Cheung T.K., Chu K.M., Chan C.K., Fung J.Y.Y., Chan P., But D., Hung I.F.N., Chan A.O.O., Yuen R.M.F., Hsu A. and Wong B.C.Y., Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection., Aliment Pharmacol Ther . 2007, 26(7): 1063-1067. |
|
Yuan H.J., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E., Lai C.L. and Yuen R.M.F., Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B, J Infect . 2007, 54: 497-503. |
|
Yuen
R.M.F., A patient with lamivudine-resistant
hepatitis B (case presentation) and How to manage drug resistance in
hepatitis B (lecture)., Beijing-Hong Kong Medical Forum 2008, |
|
Yuen
R.M.F., Achieving chronic hepatitis B
management endpoint by potent antiviral treatment with minimal drug
resistance. , |
|
Yuen
R.M.F., Antiviral resistance prevention in
chronic hepatitis B treatment. , North Asia Hepatitis B Advisory Board
Meeting: Antiviral-Drug Resistance in CHB, |
|
Yuen
R.M.F., Antiviral resistance prevention in
chronic hepatitis B treatment., Annual Convention Symposium, Philippine
Society of Gastroenterology, |
|
Yuen
R.M.F., Evolving options for treatment of
chronic hepatitis B. , BMS Symposium, |
|
Yuen
R.M.F., Future treatment landscape – pipeline
drugs. , The 11th Asia Pacific Advisory Board Meeting, |
|
Yuen R.M.F. and Lai C.L., HBV genotypes: implications for treatment and management. , Expert Rev Gastroenterol Hepatol . 2007, 1(2): 321-328. |
|
Yuen
R.M.F., Hepatitis B infection in Asia
Pacific, HBV NAT testing in an endemic region: approaching a rational
algorithm., XVIIIth Regional Congress of the International Society of
Blood Transfusion (ISBT), Asia, |
|
Yuen R.M.F., Fong D.Y.T., Wong D.K.H., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response, Hepatology. 2007, 46: 1695-1703. |
|
Yuen
R.M.F., Hepatitis B virus treatment update., Chinese
Doctors and Professional Association of Macau, |
|
Yuen
R.M.F., Hepatitis B – The way forward.
Liver Update 2007, |
|
Yuen
R.M.F., Hepatitis B – The way forward. Liver
Update 2007. , Liver Update Symposium. |
|
Yuen
R.M.F., Impact of antiviral resistance in
chronic hepatitis B management. , BMS symposium: Chronic treatment
paradigm: Thai experience, |
|
Yuen R.M.F., Tanaka Y., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., But D., Chan A.O.O., Wong B.C.Y., Mizokami M. and Lai C.L., Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2008, 48 (Suppl 2): S252. |
|
Yuen R.M.F., Liver Cancer Symposium: a critical reappraisal of current practice: Issues on screening and surveillance for HCC. , The 18th Conference of Asian Pacific Association for the Study of the Liver (APASL) Seoul, Korea, 23 – 26 March 2008.. 2008. |
|
Yuen R.M.F., Seto W.K., Chow D.H., Tsui K., Wong D.K.H., Ngai W.S., Wong B.C.Y., Fung J.Y.Y., Yuen J.C.H. and Lai C.L., Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease, Antiviral Therapy. 2007, 12: 1295-1303. |
|
Yuen
R.M.F., Management of chronic hepatitis B in
the era of potent antiviral. , The Society of Hospital Phamarcists of |
|
Yuen
R.M.F., Management of drug resistant HBV. , Cross-straits
Digestive Forum, |
|
Yuen R.M.F. and Lai C.L., Prediction of treatment outcome for lamivudine., Journal of Gastroenterology and Hepatology. 2007, 22(7): 964-5. |
|
Yuen
R.M.F., Reducing disease progression in
chronic hepatitis B – Theory meets practice. GSK symposium, |
|
Yuen
R.M.F., Reducing disease progression in
chronic hepatitis B – Theory meets practice. , Liver Update Symposium, |
|
Yuen
R.M.F., Revisiting the natural history of
chronic hepatitis B. , Annual Convention Symposium, Philippine Society of
Gastroenterology, |
|
Yuen R.M.F., Revisiting the natural history of chronic hepatitis B. , Scientific symposium, The Hong Kong Association for the Study of Liver Diseases, 3 September 2007. 2007. |
|
Yuen R.M.F., Revisiting the natural history of chronic hepatitis B., First Guangzhou-Hong Kong Joint International Symposium on Hepatology 2007, Guangahou, China, 25 November 2007.. 2007. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels, Gut. 2008, 57(1): 98-102. |
|
Yuen R.M.F., Spectrum of underlying chronic liver disease – fatty liver to chronic hepatitis to compensated cirrhosis to decompensated cirrhosis., Asian Pacific Association for the Study to Liver Working Party on Acute on Chronic Liver Failure, New Delhi, India, 22-23 January 2008. 2008. |
|
Yuen R.M.F. and Lai C.L., Telbivudine for chronic hepatitis B: The GLOBE trial. 2008;3(4):317-323., Future Virology. 2008, 3(4): 317-323. |
|
Yuen
R.M.F., Treatment Paradigms for Chronic HBV
Infection in |
|
Researcher
: Yuen YM |
|
List of Research Outputs |
|
Tang S.C.W., Leung J.C.K., Chan Y.Y., Yuen Y.M., Lan H.Y. and Lai K.N., Generating a model of accelerated murine diabetic nephropathy, Nephrology. 2008, 13: A3. |
|
Researcher
: Yueng YH |
|
List of Research Outputs |
|
Hui C.K., Zhang H.Y., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B, Journal of Hepatology. 2007, 47(2): 191-202. |
|
Researcher
: Yung SSY |
|
Project Title: |
The role of heparan sulfate proteoglycans in the pathogenesis of diabetic nephropathy and the effects of Sulodexide |
|
Investigator(s): |
Yung SSY, Chan DTM |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To study the changes in heparan sulfare proteoglycan (HSPG) biosynthesis (including separate studies on its core protein, HS chain, and charge density), the expression of sulfotransferases (enzymes that add sulfate groups to the HS chains), and HSPG degradation in db/db mice; to examine whether the changes HSPG are related to altered sequestration of growth factors that are relevant to the progression of kidney damage, namely TGF-β1, VEGF, IGF and bFGF; to determine the relationship between altered PG expression and phenotypic manifestations of DN, including proteinuria and renal function impairment; to investigate the effects of Sulodexide on disease manifestation, renal histopathology, and PG expression in db/db mice with DN. |
|
Project Title: |
The effect of mycophenolic acid on the synthesis of matrix proteins and cytokines in proximal tubular epithelial cells |
|
Investigator(s): |
Yung SSY, Chan DTM |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Background Lupus nephritis is a severe
organ manifestation of systemic lupus erythematosus (SLE) and a major cause
of morbidity worldwide. Anti-DNA antibodies are implicated in the
pathogenesis of lupus nephritis since their levels correlate with disease
activity, and they deposit in the glomerulus and tubular basement membrane of
kidneys (1-3). To date, much of the research has focused on the immunopathogenesis
of glomerular dysfunction in lupus nephritis whilst limited data is currently
available on the consequence of tubulo-interstitial injury despite the
frequent occurrence of tubulo-interstitial disease and their strong
association with less favorable renal prognosis (4). Renal proximal tubular
epithelial cells constitute the predominant cell type in the
tubulo-interstitium. Although previously considered to be mainly involved in
the transport of fluids and electrolytes, there is now compelling evidence to
suggest a critical role of proximal tubular epithelial cells in the
immunopathogenesis of various renal parenchymal diseases, undertaking an
effector role during immune-mediated inflammation and fibrosis (5, 6). In
this respect, our studies have demonstrated increased expression of IL-6
within the tubulo-interstitium of renal biopsies obtained from patients with
lupus nephritis (7). The conventional treatment for severe lupus nephritis
entails the use of corticosteroids and cyclophosphamide (8). Despite its
efficacy, prolonged or repeated use of cyclophosphamide is associated with
adverse effects, attributed in part to the metabolite acrolein, which has
genotoxic and mutagenic properties (9). Mycophenolate mofetil (MMF) is a
morpholinoethyl ester pro-drug that is converted after gastrointestinal
absorption to its active metabolite mycophenolic acid (MPA) (10). It has
established efficacy in the prevention and treatment of acute rejection after
kidney transplantation. We have recently performed the first prospective
randomized controlled study to determine the role of MMF in the treatment of
severe proliferative lupus nephritis (11). We demonstrated that MMF is as
effective as the regimen of cyclophosphamide and prednisolone in inducing
remission, but has the distinct advantage of fewer side effects (11).
Although the role of MMF/MPA on the inhibition of lymphocyte proliferation is
well known, limited data is currently available on its effect on non-immune
cells. Results from animal and in vitro studies show that MMF/MPA can inhibit
platelet derived growth factor-induced proliferation of endothelial and
vascular smooth muscle cells, decreases renal myofibroblast infiltration and
collagen deposition, and inhibits cell proliferation and matrix synthesis in
FCS-stimulated kidney mesangial cells (12-14). The mechanism by which MMF
abrogates matrix synthesis has not been elucidated. In this regard, we and
others have shown that chemical or inflammatory stimulation of mesothelial,
epithelial, or mesangial cells can induce matrix protein synthesis through
activation of protein kinase C (PKC) isomers (15-17). PKC has at least twelve
isomeric forms and plays a pivotal role in intracellular signal transduction
of hormones, cytokines and growth factors. We hypothesize that the PKC
pathway may also be involved in the modulation of cellular functions by MPA.
In an animal model of lupus nephritis, p38 MAPK contributes to autoimmune
renal injury, and plays a pivotal role in cell proliferation and induction of
cytokines (18). Whether MPA modulates MAPK in lupus nephritis remains to be
determined. The Objectives of this project: 1. To assess the role of MPA on
anti-DNA antibody mediated cell proliferation and viability in proximal
tubular epithelial cells. 2. To assess the role of MPA on anti-DNA antibody
mediated induction of cytokines, chemokines and matrix proteins in proximal
tubular epithelial cells. 3. To ascertain the mechanisms through which
anti-DNA antibodies and MPA mediate their actions on proximal tubular epithelial
cells. References 1. Tan EM. Autoantibodies to nuclear antigens (ANA): Their
immunobiology and medicine. Adv Immunol 1982; 33: 167-240. 2. Winfield JB,
Faiferman I, Koffler D. Avidity of anti-DNA antibodies in serum and IgG
glomerulate eluates from patients with systemic lupus erythematosus. J Clin
Invest 1977; 59: 90-96. 3. Magil AB, Tyler M. Tubulo-interstitial disease in
lupus nephritis. A morphometric study. Histopathology 1984; 8: 81-87. 4. Nath
KA. Tubulointerstitial changes as a major determinant in the progression of
renal damage. Am J Kidney Dis 1992; 20: 1-17. 5. Dai C, Liu Z, Zhou H, Li L.
Monocyte chemoattractant protein-1 expression in renal tissue is associated
with monocyte recruitment and tubulo-interstitial lesions in patients with
lupus nephritis. Chin Med J 2001; 114: 864-868. 6. Tang WW, Feng L, Xia Y, |
|
List of Research Outputs |
|
Chan
D.T.M., Ng Y.C.C. and Yung S.S.Y., Cytokine induction by
anti-DNA antibodies in proximal renal tubular epithelial cells is reduced by
mycophenolic acid, Journal of the American Society of Nephrology.
2007, 18: |
|
Lui
S.L., Tsang R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the
severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Tse K.C., Yung S.S.Y., Tang S.C.W., Tam S., Lai K.N. and Chan D.T.M., Atorvastatin at conventional dose did not reduce C-reactive protein in patients on peritoneal dialysis, Journal of Nephrology. 2008, 21: 283. |
|
Yung S.S.Y. and Chan D.T.M., Anti-DNA antibodies in the pathogenesis of lupus nephritis - the emerging mechanisms [invited review], Autoimmunity Reviews. 2008, 7: 317-321. |
|
Yung
S.S.Y., Tsang
R.C.W., Chen X.R. and Chan D.T.M.,
Heparin ameliorates peritoneal dialysate-induced reduction of perlecan
synthesis and cellular transdifferentiation in human peritoneal mesothelial
cells, Journal of the American Society of Nephrology. 2007, 18: |
|
Yung S.S.Y., Intrinsic cells: mesothelial cells - central player in regulating inflammation and resolution, The 12th Congress of the International Society for Peritoneal Dialysis. 2008. |
|
Yung S.S.Y. and Chan D.T.M., Peritoneal proteoglycans: much more than ground substance [invited editorial], Peritoneal Dialysis International. 2007, 27: 375-390. |
|
Researcher
: Zhang C |
|
List of Research Outputs |
|
Chan L.Y., Leung J.C.K., Zhang C., Tang S.C.W. and Lai K.N., Angiotensin II type 2
receptor-mediated ERK inhibition protects tubular epithelial cells from
pro-inflammatory damage, Journal of American Society of Nephrology.
2007, 18: |
|
Researcher
: Zhang D |
|
List of Research Outputs |
|
Zhang D., Lau C.P. and Li G.R., Regulation of hERG potassium
channel by EGFR and scr-related Tyrosiner kinases. , 9th National
Symposium of Chinese Cardiovascular Pharmacological Society. |
|
Zhang D., Lau C.P. and Li G.R., Regulation of human ether-a-go-go-related gene potassium channels by EGFR kinase and Src-related tyrosine. , FEBS J / 33rd FEBS Congress and 11th IUBMB Conference, Athens, Greece. . 2008, 275(suppl 1): 323. |
|
Researcher
: Zhang H |
|
List of Research Outputs |
|
Chen Y., Zhang H., Lu L. and Lau G., Role of Regulatory T cells in Natural Immunity and Sustained Pharmacological Control of Chronic HBV, 2007 Liver Meeting/American Association for the Study of Liver Diseases. 2008. |
|
Hui C.K., Zhang H., Bowden S., Locarnini S., Luk J.M.C., Leung K.W., Yueng Y.H., Wong A., Rousseau F., Yuen K.Y., Naoumov N.N. and Lau G., 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B, Journal of Hepatology. 2008, 48(5): 714-720. |
|
Hui C.K., Leung N., Shek T.W.H., Zhang H., Luk J.M.C., Poon R.T.P., Lo C.M., Fan S.T. and Lau G., Changes in liver histology as a surrogate endpoint of antiviral therapy for chronic HBV can predict progression to liver complications, Journal of Clinical Gastroenterology. 2008, 42(5): 533-538. |
|
Lau G., Zhang H., Li J., Hui C.K., Yeung Y.H., Wang Y.D. and Yie D.W., IL-17 stimulating HBV leaving from PBMC may help HBV clearance in serum of chronic HBV patients under pegylated interferon., In: Zhang HY, Li J, Hui CK, Yeung YH, Wang YD, Yie DW, Lau GK. , J Hepatol 2008. 48: S219. |
|
Researcher
: Zhang J |
|
List of Research Outputs |
|
Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
|
Researcher
: Zhang Q |
|
List of Research Outputs |
|
Lui
S.L., Tsang R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the
severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Researcher
: Zhang Q |
|
List of Research Outputs |
|
Lui
S.L., Tsang R.C.W., Zhang Q., Chan K.W., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the
severity of established nephritis in NZB/W F1 mice, Journal of the
American Society of Nephrology. 2007, 18: |
|
Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice, Nephrology Dialysis Transplantation. 2008, 23: 2768-2776. |
|
Lui S.L., Yung S.S.Y., Tsang R.C.W., Zhang Q., Chan K.W., Tam S. and Chan D.T.M., Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice, Lupus. 2008, 17: 305-313. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Researcher
: Zhang R |
|
Project Title: |
Modulation of dedritic cell by tumor associate protein S100P |
|
Investigator(s): |
Zhang R, Lan HY |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
S100 is a multigenic family with
intracellular and extracellular regulatory activities. S100P, a 95-amino-acid
member of the S100 family of proteins that was first purified from placenta
(1), is overexpressed in pancreatic cancer (2-4) and is consider to be an
early developmental marker of pancreatic carcinogenesis (5). It was also
found that S100P promotes pancreatic cancer growth, survival, and invasion
(6). S100P is also expressed in other human cancers, including breast, colon,
prostate, and lung. The elevated levels of S100P in breast cancer are
associated with cellular immortalization (7). In colon cancer cell lines, its
expression level was correlated with resistance to chemotherapy (8). In
prostate tumors, S100P levels were found to be androgen sensitive (9). In
lung cancer, S100P expression correlated with decreased patient survival
(10). However, despite these observations, the extracellular immunological
functions of S100P in tumorgenesis remain unknown. Dendritic cells (DCs) are
professional antigen presenting cells which not only initiate T cell immunity
by uptake, processing and presentation of specific antigens, but also induce
immune tolerance by deletion of T cells and/or induction of regulatory T
cells (T regs). (CD4+)CD25+ T regs maintain immune tolerance by suppressing
the function of CD4+ and CD8+ T cells, B cells, macrophages, DCs and NK
cells. Therefore, the crosstalk between DCs and (CD4+) CD25+ T regs play
important role in balancing of immunity and tolerance. Transforming growth
factor-beta (TGF-β) serving as a potential link between these two
professionals cells (11). Recent studies show that colon tumor cell can
convert immature dendritic cells into TGF-β-secreting cells inducing
CD4+CD25+regulatory T cell proliferation (12). Recently, we found that
BxPC-3, a S100P highly expressed human pancreatic cancer cell line,
significantly supresse DC differentiation, maturation, antigen-presentation,
and allostimulatory activity (Bharadwaj, U et al, unpublished results).
However, mechnisims of how the cancer cell suppress DC function and convert
DC inducing the T regulatory cell proliferation are yet unknown. We recently
found that S100P modulate the DC surface molecules expression and cytokine
production. This preliminary data indicates that the S100P may mediate tumor
immune escape by modulating the function of DCs. Therefore, we hypothesize
that S100P may play important role in inducing T regulatory cell
proliferation and maintain immune tolerance to pancreatic cancer by
modulating the function of DC and suppressing the function of CD4+ and CD8+ T
cells. S100P could be a potential siRNA therapeutic target and vaccine
candidate for cancer immunotherapy. There are two objectives in this proposed
study. I, To determine the role of S100P in influencing DC activation and
antigen presentation. Our working hypothesis in this specific aim is that
S100P will influence the activation of DC, resulting in the changes in DC
phenotypes and antigen presentation activities. II, To study the role of
S100P in modulating DC cytokine profiles and inducing Foxp3+CD4+CD25+ T
regulatory cell proliferation. Our working hypothesis in this specific aim is
that S100P will change the cytokine profiles of DC, specifically enhancing
TGF-β and/or IL-10 production, thereby inducing the Foxp3+CD4+CD25+ T
regulatory cell-dependent immune tolerance. The future studies will focus on
the in vivo studies in mouse. We will test the DC profiles and T regs
proliferation in mouse (or S100P transgenic mouse) bearing with S100P
overexpressed tumor cells and S100P silenced tumor cells. Reference: 1.
Becker T, Gerke V, Kube E, Weber K. S100P, a novel Ca(2+)-binding protein
from human placenta. cDNA cloning, recombinant protein expression and Ca2+
binding properties. Eur J Biochem. 1992; 207(2):541-7. 2. Logsdon CD, Simeone
DM, Arumugam T, et al. Molecular profiling of pancreatic adenocarcinoma and
chronic pancreatitis identifies multiple genes differentially regulated in
pancreatic cancer. Cancer Res 2003;63:2649–57. 3. Crnogorac-Jurcevic T, Missiaglia
E, Blaveri E, et al. Molecular alterations in pancreatic carcinoma:
expression profiling shows that dysregulated expression of S100 genes is
highly prevalent. J Pathol 2003;201:63–74. 4. Sato N, Fukushima N,
Matsubayashi H, Goggins M. Identification of maspin and S100P as novel
hypomethylation targets in pancreatic cancer using global gene expression
profiling. Oncogene 2004;26:1531–8. 5. Ohuchida K, Mizumoto K, Egami T,
Yamaguchi H, Fujii K, Konomi H, Nagai E, Yamaguchi K, Tsuneyoshi M, Tanaka M.
S100P is an early developmental marker of pancreatic carcinogenesis. Clin
Cancer Res. 2006;12(18):5411-6. 6. Arumugam T, Simeone DM, Van Golen K,
Logsdon CD. S100P promotes pancreatic cancer growth, survival, and invasion.
Clin Cancer Res. 2005; 11(15):5356-64. 7. Guerreiro DS, Hu YF, Russo IH, et
al. S100P calcium-binding protein overexpression is associated with
immortalization of human breast epithelial cells in vitro and early stages of
breast cancer development in vivo. Int J Oncol 2000; 16:231–40 8. Bertram J,
Palfner K, Hiddemann W, Kneba M. Elevated expression of S100P, CAPL and MAGE |
|
List of Research Outputs |
|
Zhang
R., Editor, Asian Pacific Journal of
Tropical Medicine. |
|
Zhang
R., Li M., Chen C. and Yao Q., Enhancement of
SHIV Virus-like Particles Induced Dendritic Cell Activation and Boost Immune
Responses against HIV by CD |
|
Zhang
R., Li M., |
|
Researcher
: Zhang X |
|
List of Research Outputs |
|
Lau C.P., Zhang X., Miao L. and Tse H.F., 频率适应性起搏, In: 陈新, 临床心律失常学-电生理和治疗, 北京, 人民卫生出版社, 2007. |
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Lau C.P., Tse H.F. and Zhang X., 频率适应性起搏, 中华心律失常学杂志, 2007, 10. |
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Siu D.C.W., Zhang X., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., Recurrence of Atrial Fibrillation in hyperthyroidism related atrial fibrillation: A matched case-control study., Heart Rhythm Society Scientific Meeting 2008. |
|
Wang
M.M., Tse H.F., Lee K.L.F., Zhang X., Siu D.C.W. and Lau C.P., Differential in Inter-atrial
Dyssynchrony and Atrial Mechanical Function in Sick Sinus Syndrome with or
without Paroxysmal Atrial Fibrillation (Oral presentation), The American
Heart Assosiation Scientific Sessions |
|
Wang
M.M., Siu D.C.W., Zhang X., Lau C.P. and Tse H.F., Is atrial dyssynchrony
important in sinus node disease with or without atrial fibrillation?, The
American Society of Echocardiography, |
|
Wang M.M., Zhang X., Lee K.L.F., Siu D.C.W., Lau C.P. and Tse H.F., Is atrial electromechanical dyssynchrony important in sick sinus syndrome patients with or without paroxysmal atrial fibrillation?, XIII World Congress on Cardiac Pacing and electrophysiology, Italy, December 2-6. 2007. |
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Wang M.M., Lau C.P., Zhang X., Siu D.C.W., Lee K.L.F. and Tse H.F., Reversal of left ventricular diastolic dyssynchrony and function after upgrade of longstanding right ventricular apical to septal pacing., XIII World Congress on Cardiac Pacing and electrophysiology, Italy. December 2-6,. 2007. |
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Zhang X., Chen H., Siu D.C.W., Yiu K.H., Chan W.S., Lee K.L., Chan H.W., Lee S.W., Fu G.S., Lau C.P. and Tse H.F., New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function., Journal of Cardiovascular Electrophysiology. 2008, 19(2): 136-141. |
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Researcher
: Zhang Y |
|
List of Research Outputs |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Researcher
: Zhao Y |
|
Project Title: |
Development of an in vitro assay for methylation-dependent genetic mutation based on linking in-frame CGA polynucleotides to the alpha-lacZ reporter gene system |
|
Investigator(s): |
Zhao Y, Epstein R |
|
Department: |
Medicine |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2005 |
|
Abstract: |
|
CpG dinucleotides in human DNA can be
uniquely modified by cytosine methyltransferases, yielding the 'fifth base'
of DNA, 5-methylcytosine (5MC). 5MC residues clustered within CpG islands act
as binding sites for linker proteins that recruit histone deacetylases, thus
triggering chromatin condensation and transcriptional repression that is
epigenetically transmissible via either germline or somatic cells. If the
cell tolerates longterm transcriptional repression of such genes, 5MC
residues within the coding sequence may persist in the absence of transcription-coupled
repair; since oxidant deamination of 5MC yields thymidine (T), CpG
methylation predisposes to a ten-fold excess of CG to TA transitional
mutations within the coding sequence as a 'marker' or 'fossil' of repressed
transcription (Rideout et al, 1990; Soussi, et al, 2003). Yet despite this
insight, little is known as to the dynamics and function of CpG sites in the
open reading frame of tumor suppressor genes (TSGs, e.g., p53; Rodin et al,
1998). Our recent work has confirmed that the CGA codon specifying arginine
is specifically associated with a pronounced mutational asymmetry in TSGs
associated with familial cancer syndromes, consistent with the observation
that this codon is unique in its ability to undergo a single-base
methylation-dependent mutation to a stop codon (viz., CGA TGA; Table 1). Table 1 Asymmetry pattern of CGN germline
mutations in human TSGs Gene CGA CGT CGC CGG TGA CAA TGT CAT TGC CAC TGG CAG
APC 125** 0 0 0 1 0 3 0 TP53 10** 0 12 10 38 3 16 17 RB1 126** 0 0 0 0 0 0 0
MLH1 26** 0 0 0 0 0 0 0 VHL 18* 7 0 0 1 0 24 28 ATM 4 0 0 0 4 0 0 2 MSH2 6* 0
0 0 0 0 0 0 ** p < 0.001, p < 0.05, based on binomial
distribution.Further evidence for the biological significance of the CGA
codon is the finding that it is topographically clustered within TSGs such as
p53, unlike other arginine-encoding codons: Table 2 Clustered CGA(CGN) codons
in TP53 gene*Codons CGA CGG AGA AGG Codon position 196, 213, 306, 342 248,
267, 282 65, 209, 280 174, 249, 363 Cluster parameter h(2,4,392,18)
h(3,3,392,99) h(2,3,392,145) h(2,3,392,76) and p value 0.0110 0.0157 0.2588
0.0904 h(2,4,392,37) h(2,3,392,72) h(2,3,392,114) 0.0432 0.0821 0.1797
h(4,4,392,147) h(3,3,392,216) h(3,3,392,189) 0.0193 0.1663 0.1112 (*Data
calculated without assuming a hypergeometric distribution) Such CGA
clustering is similarly evident in other TSGs such as RB1 and APC, with the
distribution of clusters suggesting a 'mutational splicing' significance
(data not shown). Hence, the position of the CGA clusters tends to separate
the gene into loss-of-function subunits (e.g., in TP53, the 196/212 and
306/342 CGA clusters demarcate the DNA-binding domain, which also
participates in mitochondrial apoptosis). We therefore speculate that CGA
clustering represents a methylation-dependent genotype that is evolutionarily
advantageous for the species (favouring adaptability) but hazardous for
individuals (favouring genetic instability and, hence, loss of TSG function
leading to clonal microevolution of cancer).Hence, in this small project
application, we seek to explore a new hypothesis: namely, that the unique
vulnerability of CGA codons to methylation-dependent nonsense (TGA) mutation
can be exploited (i) to form the basis for a mutational assay based on the
well-known alpha-lacZ reporter gene system used to investigate cancer and
ageing in transgenic mouse models, and thus (ii) to clarify the oncogenetic
role of CGA. The objectives of this funding application are:1. To exploit the
foregoing insights regarding the CGA codon to develop a useful, and potentially
patentable, in vitro assay system for methylation-dependent mutation;2. To
exemplify the assay using conditions that will putatively favour or inhibit
DNA methylation, forming the basis of a peer-reviewed publication in the
epigenetic field;3. To use this assay (+/- patent) and submission/publication
to compete for a 2006 RGC grant in which we will propose to develop an in
vivo CGA-LacZ-based transgenic mouse model system of methylation-dependent
mutation and/or ageing;4. To permit continuation of the laboratory programme
over the next 12 months while awaiting publication of manuscripts to support
external funding applications in 2006.References1. Soussi T, Beroud C. (2003)
Significance of TP53 mutations in human cancer: a critical analysis of mutations
at CpG dinucleotides. Hum Mutat. 21(3):192-200. 2. Rideout WM 3rd, Coetzee
GA, Olumi AF, Jones PA.(1990) 5-Methylcytosine as an endogenous mutagen in
the human LDL receptor and p53 genes. Science. 249(4974):1288-90. 3. Rodin
SN, Rodin AS.(1998) |
|
Researcher
: Zhou H |
|
List of Research Outputs |
|
Tan K.C.B., Zhou H., Shiu S.W.M. and Wong Y., Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus, American Diabetes Association 68th Scientific Sessions, San Francisco, USA. 2008. |
|
Zhou H., Tan K.C.B., Shiu W.M.S. and Wong Y., Increased serum advanced glycation end products is associated with impairment in HDL antioxidative capacity in diabetic nephropathy, Nephrol Dial Transplant. 2008, 23: 927-33. |
|
Researcher
: Zhou L |
|
List of Research Outputs |
|
Chung A.C.K., Lan X.R., Zhou L., Heuchel R. and Lan H.Y., Loss of Smad7 Promotes Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 11th Asian Pacific Congress of Nephrology. 2008. |
|
Chung
A.C.K., Lan X.R., Zhou L. and Lan H.Y., Loss of Smad7 Promotes Renal
Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice, 13th
Medical Research Conference of Department of Medicine ( |
|
Lan X.R., Chung A.C.K., Zhou L., Li A.G., Wang X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis., 43th Annual Meeting Of Australian New Zealand Society Of Nephrology, Gold Coast, Australia (8-12 Sep, 2007). 2007. |
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Lan X.R., Chung A.C.K., Zhou L., Wong X.J. and Lan H.Y., Mice Overexpressing Tgf-beta1 Are Protected Against Crescentic Glomerulonephritis, Journal Of American Society Of Nephrology. 2008, 19: 233-242. |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective Role Of Latent
Tgf-beta |
|
Lan
X.R., Chung A.C.K., Zhou L., Wang X.J. and Lan H.Y., Protective role of latent
Transformating Growth Factor-beta |
|
Researcher
: Zhu S |
|
List of Research Outputs |
|
Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, The Eighth International Conference on Systems Biology; 1-6 October, 2007; California, USA. . 2007. |
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Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007. |
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Lee M.Y.K., Tse H.F., Zhu S., Man R.Y.K. and Vanhoutte P.M.G.R., Genomic changes in regenerated porcine coronary arterial endothelial cells , Arterioscler Thromb Vasc Biol. 2007, 27: 2443-2449. |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Researcher
: Zhu S |
|
List of Research Outputs |
|
Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, The Eighth International Conference on Systems Biology; 1-6 October, 2007; California, USA. . 2007. |
|
Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007. |
|
Lee M.Y.K., Tse H.F., Zhu S., Man R.Y.K. and Vanhoutte P.M.G.R., Genomic changes in regenerated porcine coronary arterial endothelial cells , Arterioscler Thromb Vasc Biol. 2007, 27: 2443-2449. |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Tse H.F., Siu D.C.W., Zhu S., Songyan L., Zhang Q., Lai W.H., Kwong Y.L., Nicholls J. and Lau C.P., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium, European journal of heart failure. 2007, 9(8): 747-753. |
|
Researcher
: Zhu W |
|
List of Research Outputs |
|
Yang Y.H., Wang Y., Lam K.S.L., Yao M.H., Cheng K.Y., Zhang J., Zhu W., Wu D. and Xu A., Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4., Arterioscler Thromb Vasc Biol. . 2008, 28: 835-40. |
|
Zhu W., Cheng K.Y., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention, Clin Sci (London). 2008, 114: 361-74 (Invited Review). |
|
Researcher
: Zou B |
|
List of Research Outputs |
|
Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., Gu Q., Li Z., Wang Y., Wong B.L.W. and Wong B.C.Y., Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo, Int J Cancer. 2008, 122: 2858-63. |
|
Li Z.,
Qiao L., Dai Y., Zou B., Ma J., Lan H.Y. and Wong B.C.Y., Role of cIAP |
|
Ma J., Chen M., Wang J., Xia H.H.X., Zhu S., Liang Y., Gu Q., Qiao L., Dai Y., Zou B., Li Z., Zhang Y., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Carcinogenesis. 2008, 29: 1327-33. |
|
Ma J., Chen M.H., Liang Y.J., Gu Q., Wang J., Qiao L., Dai Y., Zou B., Lan H.Y. and Wong B.C.Y., Pancreatic-duodenal homeobox 1 (PDX1) functions as a tumor suppressor in gastric cancer, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Zou B., Ma J., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor {gamma} ligand-induced growth inhibition in colon cancer, Mol Cancer Ther. 2008, 7: 2203-2211. |
|
Qiao
L., Li H.Y., Li Z., Zou B. and Wong B.C.Y., Gene expression profile in
colon cancer cells in response to troglitazone: impact of XIAP expression, Digestive
Disease Week, |
|
Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., Zou B., Rocken C , Ebert MP and Wong B.C.Y., Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. , Cancer Lett. 2008, 268: 260-71. |
|
Qiao L., Gu Q., Dai Y., Shen Z., Liu X.Y., Qi R., Ma J., Zou B., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 suppresses angiogenesis in mouse endothelial cells, Tumor Biology. 2008, 29: 122-129. |
|
Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86. |
|
Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71. |
|
Zou B. and Wong B.C.Y., Do serrated adenomas have higher malignant potential than traditional adenomas? , J Gastroenterol Hepatol. . 2007, 22 (11): 1701–1703. |
|
Zou
B., Yang
Y., Zeng H., Wong L.W.,
Jiang S. and Wong B.C.Y., New
function of Krit 1 and as a New Interactor of XAF |
|
Zou B., Pang R.W.C., Qiao L., Wong B.L.W., Ma J., Wang Y., Zeng H.U.I., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1) regulates p53-mediated apoptosis by a negative feedback loop, Digestive Disease Week, San Diego, CA, USA, May 17-22. 2008. |
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