Dept of Psychiatry

DEPT OF PSYCHIATRY

Researcher : Chan SY

List of Research Outputs

Lee A.M., Lam T.P., Chong C.S.Y., Chu L.W. and Chan S.Y., A study of androgen deficiency and its relationship with psychological factors in Hong Kong, Poster presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Researcher : Chen EYH

Project Title:	Outcome of an early intervention programme for psychosis (EASY): a case controlled study
Investigator(s):	Chen EYH, Chan RCK
Department:	Psychiatry
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	09/2005

Abstract:

The study will help identify the effectiveness of early intervention for psychosis in Hong Kong. In addition to a broad range of outcome asssessment, it will provide service utilization and functioning data for cost effectiveness evaluation. The study will also identify areas of unmet needs and provide guidance for future service development.

Project Title:	Duration of maintenance anti-psychotic therapy after first-episode schizophrenia: a double-blind randomized placebo-control relapse prevention study
Investigator(s):	Chen EYH, Law CW, Chiu CPY
Department:	Psychiatry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2005

Abstract:

To study the efficacy of relapse prevetion by maintenance antipsychotic therapy in patients who had responded well and remained well for 12 months following a first-episode schizophrenia.

List of Research Outputs

Chan W.S.C., Yip P.S.F., Wong P.W.C. and Chen E.Y.H., Suicide and Unemployment: What are the Missing Links?, Archives of Suicide Research. 2007, 11: 327-335.

Chen E.Y.H., Hui C.L.M., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., A double-blind randomized placebo-controlled study of relapse prevention in remitted first-episode psychosis patients following one year of maintenance therapy, Schizophrenia Research. 2008, 98: 11.

Chen E.Y.H., A double-blind randomized placebo-controlled study for relapse prevention with quetiapine (400mg/d) in remitted 1st episode psychosis, AstraZeneca Neuroscience Investigator Sponsored Studies Meeting, Stockholm, Nov 28-30, 2007. 2007.

Chen E.Y.H., Editorial Board (2003-present), Schizophrenia Research. 2008.

Chen E.Y.H., Editorial Board (2005-present), Chinese Medical Journal. 2008.

Chen E.Y.H., Editorial Board (2006), Hong Kong Journal of Psychiatry. 2008.

Chen E.Y.H., Editorial Board (from 2006-present), Early Intervention in Psychiatry. 2008.

Chen E.Y.H., Relapse and maintenance therapy for first episode psychosis: critical issues: east and west, The 3rd Annual Meeting of Japanese Society of Schizophrenia Research, Tokyo, Mar 13-16, 2008. 2008.

Chen E.Y.H., Relapse prevention in Early Psychosis: a phase specific approach, The 10th Annual Meeting of the Korean Academy of Schizophrenia, Seoul, May 29-30, 2008. 2008.

Chen E.Y.H., Reviewer (1997-present), Psychological Medicine. 2008.

Chen E.Y.H., Reviewer (2000-present), Biological Psychiatry. 2008.

Chen E.Y.H., Reviewer (2001-present), Acta Psychiatrica Scandinavica. 2008.

Chen E.Y.H., Reviewer (2001-present), Journal of Abnormal Psychology. 2008.

Chen E.Y.H., Reviewer (2002-present), Schizophrenia Research. 2008.

Chen E.Y.H., Reviewer (2005-present), British Journal of Psychiatry. 2008.

Chen E.Y.H., Reviewer (2005-present), Cognitive Neuropsychiatry. 2008.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Hui C.L.M., Wong G.H.Y., Lam Y.K., Chow P.P.L. and Chen E.Y.H., Patient-clinician Communication and Needs Identification for Outpatients with Schizophrenia in Hong Kong: Role of the 2-COM Instrument, Hong Kong Journal of Psychiatry. 2008, 18(2): 69-75.

Hui C.L.M., Chen E.Y.H., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., Predictors for relapse in a double-blind randomized placebo-controlled discontinuation study of remitted first-episode psychosis patients, Schizophrenia Research. 2008, 98: 13.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Ng R.M.K., Pearson V.J., Lam M., Law C.W., Chiu C.P.Y. and Chen E.Y.H., What Does Recovery From Schizophrenia Mean? Perceptions of Long-Term Patients, International Journal of Social Psychiatry. SAGE Publications, 2008, 54: 118-130.

Ran M.S., Chan C.L.W., Chen E.Y.H., Tang C.P., Lin F.R., Li L., Li S.G., Mao W.J., Hu S.H., Schwab G. and Conwell Y., Mortality of Geriatric and Young Patients with Schizophrenia in the Community, Suicide and Life Threatening Behaviour. 2008, 38(2): 143-151.

Ran M.S., Mao W.J., Hu S.H., Tang C.P., Lin F.R., Li L., Li S.G., Chen E.Y.H., Chan C.L.W. and Conwell Y., Never-treated patients with schizophrenia in rural China, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 76.

Ran M.S., Mao W.J., Hu S.H., Tang C.P., Lin F.R., Li L., Li S.G., Chen E.Y.H., Chan C.L.W. and Conwell Y., Never-treated patients with schizophrenia in rural china, Schizophrenia Research. 2008, 98: 76.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 181.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 181.

Wong P.W.C., Chan W.S.C., Chen E.Y.H., Chan S.S.M., Law Y.W. and Yip P.S.F., Suicide among adults aged 30-49: a psychological autopsy study in Hong Kong, BMC Public Health. Biomed Central Ltd, 2008, 8:147: 1471-2458.

Researcher : Chen RYL

Project Title:	Psychological and biological risk factors associated with Pathological Gambling
Investigator(s):	Sham PC
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To identify psychological risk factors in terms of personality traits as well as genetic risk factors in terms of genetic polymorphisms with respects to certain candidate genes associated with Pathological Gambling (PG) in Hong Kong Chinese; to figure out the patterns in terms of the risk factors mentioned in pathological gamblers engaging in different forms of gambling.

Researcher : Cherny SS

List of Research Outputs

Cherny S.S., Associate Editor (from 1997 to present), Behavior Genetics. 2008.

Cherny S.S., Associate Editor, Behavior Genetics. Springer, 2007.

Cherny S.S., Chapter 9: Regression methods for linkage analysis, In: B. M. Neale, M. A. R. Ferreira, S. E. Medland, and D. Posthuma, Statistical genetics: Gene Mapping through Linkage and Association. Abingdon, U.K., Taylor & Francis Group, 2008, 153-179.

Cherny S.S., Garcia-Barcelo M.M., Tang S.M., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung’s disease, 38th Annual meeting of the Behavior Genetics Association (abstract appears in Volume 38 of Behavior Genetics). 2008, 38.

Cherny S.S., Member, Advisory Board (from 2004 - present), Journal of Child Psychology and Psychiatry. 2008.

Cherny S.S., Member, Advisory Board, Journal of Child Psychology & Psychiatry. 2007.

Cherny S.S., Member, Editorial Advisory Board, Open Genetics Reviews. Bentham Science, 2007.

Cherny S.S., Member, Editorial Advisory Board, The Open Genomics Journal. Bentham Science, 2007.

Dyment D.A., Cader M.Z., Datta A., Broxholme S.J., Cherny S.S., Willer C.J., Ramagopalan S., Herrera B.M., Orton S., Chao M., Sadovnick A.D., Hader M., Hader W. and Ebers G.C., A ﬁrst stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2008, 147B: 467-472.

Garcia-Barcelo M.M., Tang S.M., Cherny S.S., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung's disease, 57th Annual Meeting of the American Society of Human Genetics. 2007.

Gayan J., Brocklebank D., Andresen J.M., Alkorta-Aranburu G., The US-Venezuela Collaborative Research Group .., Cader M.Z., Roberts S.A., Cherny S.S., Wexler N.S., Cardon L.R. and Housman D.E., Genomewide Linkage Scan Reveals Novel Loci Modifying Age of Onset of Huntington's Disease in the Venezuelan HD Kindreds, Genetic Epidemiology. 2008, 32: 445-453.

Goode E.L., Cherny S.S., Christian J.C., Jarvik J.P. and de Andrade M., Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins, Twin Research and Human Genetics. 2007, 10: 703-711.

Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32.

Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45.

Tam P.K.H., Tang S.M., Garcia-Barcelo M.M., Cherny S.S. and Sham P.C., Genome-wide association analysis of Hirschsprung's disease, The 9th International Meeting on Human Genome Variation and Complex Genome Analysis. 2007.

Willer C.J., Dyment D.A., Cherny S.S., Ramagopalan S.V., Herrera B.M., Morrison K.M.E., Sadovnick A.D., Risch N.J. and Ebers G.C., A genome-wide scan in forty large pedigrees with multiple sclerosis, Journal of Human Genetics. 2007, 52: 955-962.

Researcher : Cheung C

List of Research Outputs

Cheung C., Diffusion tensor imaging pre-procsssing methods and application in autism research, 2008.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Researcher : Cheung V

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Cheung V., Structural white matter abnormalities in never-medicated patients WITH first-episode schizophrenia: a diffusion tensor imaging study, 2008.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Toulopoulou T., Chua S.E., Lam I., Cheung V., Murray R. and David A.S., Evidence of normal hearing laterality in familial schizophrenia patients and their relatives, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007, 147(1): 73-76.

Researcher : Chiu CPY

List of Research Outputs

Chen E.Y.H., Hui C.L.M., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., A double-blind randomized placebo-controlled study of relapse prevention in remitted first-episode psychosis patients following one year of maintenance therapy, Schizophrenia Research. 2008, 98: 11.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Hui C.L.M., Chen E.Y.H., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., Predictors for relapse in a double-blind randomized placebo-controlled discontinuation study of remitted first-episode psychosis patients, Schizophrenia Research. 2008, 98: 13.

Ng R.M.K., Pearson V.J., Lam M., Law C.W., Chiu C.P.Y. and Chen E.Y.H., What Does Recovery From Schizophrenia Mean? Perceptions of Long-Term Patients, International Journal of Social Psychiatry. SAGE Publications, 2008, 54: 118-130.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 181.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 181.

Researcher : Chua SE

Project Title:	Brain mapping social impairment in autism
Investigator(s):	Chua SE, Fung PCW, Tai KS, McAlonan GM
Department:	Psychiatry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To determine what regions of brain contribute to social impairment in children with autism; the results of the study will help elucidate the causes of autism, and perhaps lead to more effective treatments.

Project Title:	Anatomy and connectivity in Attention Deficit-Hyperactivity Disorder (ADHD). A voxel based morphometry and diffusion tensor imaging study.
Investigator(s):	Chua SE, McAlonan GM, Khong PL, Tai KS, Cheung V
Department:	Psychiatry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

1) To assess the integrity of white matter tracts connecting regions of neuropathology considered important to control of attention and executive processes. With the advent of Diffusion Tensor Imaging (DTI) we are now in a position to do this and in the current project will apply this "cutting-edge" technology to the problem of ADHD 2) This study will rescan the children scanned 4 years ago in our first investigation and examine brain maturational progress in conjunction with symptom rating.

Project Title:	Early effects of anti-psychotic drugs on brain growth and gene expression in schizophrenia. A pilot study.
Investigator(s):	Chua SE, McAlonan GM, Chen EYH, Wong JGWS, Law CW, Chiu CPY
Department:	Psychiatry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2006

Abstract:

OBJECTIVES : This is a pilot study to investigate the feasibility of using MRI and microarray to study the early effects of anti-psychotic drugs on brain growth and gene expression. Since microarray is expensive, with budget constraints it is fair to adopt a sample size of n=6. Our project objectives are to determine the feasibility of : (1) recruitment of subjects with first-onset schizophrenia (n=12) for MRI brain scan at time 0 and 3 weeks, (2) peripheral blood taking of these subjects at weeks 0, 3(3) microarray analysis protocol (n=6, see below) at the Genome Research Centre . SUMMARY : Schizophrenia is a heritable, serious mental disorder, affecting 1% people worldwide. It usually presents in young adults with psychosis i.e. hallucinations or delusions. Anti-psychotic drugs classically block dopamine receptors in the basal ganglia (striatum) in the brain and take effect after 3 weeks (Johnstone et al 1978). There are a range of brain morphological abnormalities in schizophrenia including ventricular enlargement, smaller brain volume, reduced fronto-temporal volume, increased caudate volume (Wright et al 2000) but these have mainly been studied in chornic patients who have been treated with neuroleptic medication. Chronicity and neuroleptic treatment are known to affect interpretation of brain morphological differences. Thus, in recent years, the research focus in brain imaging has turned to newly-ill and neuroleptic-naïve patients. In the first comprehensive voxel-based MRI study of never-medicated patients with first episode of schizophrenia, we reported significantly smaller volumes of caudate nuclei of the dopamine-rich basal ganglia (Chua et al, 2005a, in submission). Current evidence suggests anti-psychotics reverse this abnormality after 3 (Massana et al 2005) to 15 months (Chakos 1994). However, our pilot data comparing medicated and never-medicated patients with schizophrenia clearly suggested caudate volume normalization as early as 3 weeks post-treatment (Chua et al, 2005b, in submission). Coinciding with clinical recovery, it suggests a role for anti-psychotic agents in gene expression controlling brain growth. We now ask : (1) Can this novel effect be confirmed in a single cohort of individuals pre and post treatment and what is its genetic basis? We propose a prospective longitudinal MRI and gene expression study of a single patient cohort with first-episode schizophrenia (n=20). Each will have MRI brain scan before and 3 weeks after treatment to assess brain morphology, with blood samples drawn at weekly intervals for microarray analysis of genetic markers for brain growth. No previous study has examined such early treatment-induced brain changes. This will help to provide a benchmark for assessing effectiveness of drugs in the early treatment of schizophrenia and open new avenues for drug development. PURPOSE : We propose to use MRI brain in a single group of patients with schizophrenia to demonstrate that a robust neurotrophic effect occurs within 3 weeks of treatment as symptoms improve. In addition, we shall perform a microarray analysis to study candidate gene markers which govern brain neurotrophic changes and clinical response. KEY ISSUES & PROBLEMS ADDRESSED : 1. Anti-psychotic drugs markedly reduce symptoms within the first 3 weeks of treatment (Johnstone et al 1978) and 68% of the improvement at 1 year is achieved within the 1st month (Leucht et al 2005). However, the underlying mechanism for this time lag to clinical effect is not understood. 2. In a recent study, our group found that patients with schizophrenia (n=29) who had never previoulsy been exposed to any medication, have smaller regional brain volumes compared to typically developing individuals (n=40) (Chua et al, a, in submission). In another related study, we found that a similar group of schizophrenic patients (n=12) who had received antipsychotic medication for 3 weeks showed early "normalisation" of these above brain volume deficits ie the deficits appeared to reverse especially in the (dopamine-rich) basal ganglia (striatum) of the brain. Therefore the issue is whether this represents an early neurotrophic effect which corresponds to clinical response. 3. Therefore this pilot study addresses the feasibility of recruiting a single cohort (n=12) of patients who will (i) undergo MRI brain scan at weeks 0 and 3 and (ii) have perpheral whole blood-taking at weekly intervals for gene expression pattern changes during early 3 weeks of treatment. The purpose of this is (iii) to identify genes which may be involved in early symptom response and be involved in control of early brain volume changes. In other words, this project addresses the core question of whether treatment effectiveness might depend on neural circuity "re-wiring" (Konradi & Heckers 2001).

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Chua S.E., A DTI Study of first-episode schizophrenia., The Institute of Psychiatry, London, UK. . 2007.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Chung A.K.K. and Chua S.E., Acute urinary retention associated with SSRI and Ziprasidone, Journal of Clinical Psychopharmacology. 2007, 27(5): 517-518.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Toulopoulou T., Chua S.E., Lam I., Cheung V., Murray R. and David A.S., Evidence of normal hearing laterality in familial schizophrenia patients and their relatives, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007, 147(1): 73-76.

Researcher : Chui HW

List of Research Outputs

Chui H.W., Lee A.M., Lau S.M.S.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Family factors, depression and high-risk behaviours among Chinese adolescents in Hong Kong, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Moderating effects of family factors on the relationship between traditionality-modernity and high-risk behaviours, Paper presented at the 12th Postgraduate Symposium, Dec 14, 2007, Hong Kong. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Stewart S.M., Lee P.W.H. and Lam T.H., The impact of traditionality and individualism on problem behaviors among Hong Kong adolescents, World Mental Health Conference. 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chui H.W., Fong D.Y.T., Kwan C.W., Chong C.S.Y. and Tang L.C.H., Prevalence, course and risk factors of disordered eating during pregnancy and in the postpartum period, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chong C.S.Y., Chui H.W. and Fong D.Y.T., Prevalence, course, and risk factors of antenatal anxiety and depression, Obstetrics & Gynecology. 2007, 110 (5): 1102-1112.

Researcher : Chung AKK

List of Research Outputs

Chung A.K.K. and Chua S.E., Acute urinary retention associated with SSRI and Ziprasidone, Journal of Clinical Psychopharmacology. 2007, 27(5): 517-518.

Researcher : Chung KF

Project Title:	Seizure threshold of unilateral electroconvulsive therapy
Investigator(s):	Chung KF, Wong SJ
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/2001

Abstract:

To find out the seizure threshold of electroconvulsive therapy and its predictors in Chinese.

Project Title:	Influence of a psychiatric clerkship on medical students' attitudes toward psychiatry and mental patients
Investigator(s):	Chung KF
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/2002

Abstract:

To compare the effect of a standard clerkship with one augmented with a 1-hour stigma-changing programme on students' attitudes toward mental illness.

Project Title:	Response to moderately suprathreshold unilateral (UL) electroconvulsive therapy (ECT): an examination of possible predictors
Investigator(s):	Chung KF, Irwin MG
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2002

Abstract:

To examine factors that associate with response to moderately suprathereshold unilateral ECT.

List of Research Outputs

Chung K.F., Pharmacological treatment for insomnia, Sleeplessness in Hong Kong - from infancy to old age, Hong Kong, Mar 29-30, 2008.

Chung K.F. and Cheung M.M., Sleep-wake patterns and sleep disturbance among Hong Kong Chinese adolescents, Sleep. 2008, 31(2): 185-94.

Chung K.F., Validity of the Mood Disorder Questionnaire (MDQ) in the general population in Hong Kong, 3rd Biennial Conference of the International Society for Bipolar Disorders, India, Jan 2008 . 2008.

Chung K.F., Tso K.F., Wong M.M.C. and Chung T.Y., Validity of the Mood Disorder Questionnaire (MDQ) in the general population in Hong Kong, 3rd Biennial Conference of the International Society for Bipolar Disorders, India, January 28-29, 2008.

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial of Acupuncture for Primary Insomnia, 12th Research Postgraduate Symposium, the University of Hong Kong, Li Ka Shing Facutly of Medicine, Hong Kong, Dec 12 & 14, 2007.

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., Acupuncture for Primary Insomnia: A Randomized Placebo-Controlled Trial, T.W.G.H.S. Eddie Wang Symposium on Integrated Chinese and Western Medicine, Hong Kong, Nov 2-3, 2007.

Researcher : Deng Y

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Researcher : Deng Y

List of Research Outputs

Researcher : Fung PCW

Project Title:	Development of a novel natural antioxidant with strong anti-aging and protective properties for skin
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	07/2002

Abstract:

To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.

Project Title:	Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.

Project Title:	High level brain activity studies and applications
Investigator(s):	Fung PCW
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2004

Abstract:

To better understand and utilize the functioning of the brain.

Researcher : Helmeste DM

List of Research Outputs

Tang S.W., Chu E., Hui T.C.K., Helmeste D.M. and Law C.L.P., Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects, Neuroscience Letters. Ireland, 2007 Elsevier Ireland Ltd, 2007, 431: 62-65.

Researcher : Ho TP

List of Research Outputs

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Researcher : Hui CLM

List of Research Outputs

Chen E.Y.H., Hui C.L.M., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., A double-blind randomized placebo-controlled study of relapse prevention in remitted first-episode psychosis patients following one year of maintenance therapy, Schizophrenia Research. 2008, 98: 11.

Hui C.L.M., Wong G.H.Y., Lam Y.K., Chow P.P.L. and Chen E.Y.H., Patient-clinician Communication and Needs Identification for Outpatients with Schizophrenia in Hong Kong: Role of the 2-COM Instrument, Hong Kong Journal of Psychiatry. 2008, 18(2): 69-75.

Hui C.L.M., Chen E.Y.H., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., Predictors for relapse in a double-blind randomized placebo-controlled discontinuation study of remitted first-episode psychosis patients, Schizophrenia Research. 2008, 98: 13.

Researcher : Hui TCK

List of Research Outputs

Tang S.W., Chu E., Hui T.C.K., Helmeste D.M. and Law C.L.P., Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects, Neuroscience Letters. Ireland, 2007 Elsevier Ireland Ltd, 2007, 431: 62-65.

Researcher : Khong PL

Project Title:	To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies
Investigator(s):	Khong PL, Cheung PT
Department:	Diagnostic Radiology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2002

Abstract:

To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone.

Project Title:	Whole body magnetic resonance (MR) screening in primary plasmacytomas
Investigator(s):	Khong PL
Department:	Diagnostic Radiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas.

Project Title:	Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury
Investigator(s):	Khong PL, Kwong DLW, Chan GCF
Department:	Diagnostic Radiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2005

Abstract:

Treatment-induced neurotoxicity is prevalant and impacts significantly on the lives of childhood brain tumour survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to be the major contributory factor that causes these deficits (Johnson et al., 1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that white matter is predisposed to radiation-induced injury and that it may be the substrate of neurocognitive deterioration. There is emerging evidence that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is sensitive in detecting and monitoring white matter injury in these patients. (Khong et al., 2005b; Khong et al., 2003; Khong et al., 2005a; Leung et al., 2004b). We aim to explore and describe an optimal method to map whole brain radiation dose distribution to the FA images of childhood brain tumour survivors.

Project Title:	Whole body MR imaging of bone marrow in children with Acute Lymphoblastic Leukemia (ALL): evaluation of its role in diagnosis, treatment monitoring and response prediction.
Investigator(s):	Khong PL, Chan GCF, Kwong DLW
Department:	Diagnostic Radiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2006

Abstract:

We aim to determine the role of whole body MRI, a relatively new technique in MRI, in the evaluation of the bone marrow in children with acute lymphoblastic leukaemia (ALL). MRI is the most sensitive technique for the detection of bone marrow pathologies and has become the method of choice for bone marrow imaging. However, prior to the advent of whole body MRI, imaging the marrow has been restricted to selected areas of the bony skeleton because of long imaging times. Recent advances in MRI, particularly the development of fast imaging sequences have significantly reduced imaging times so that the whole body can now be imaged in 15-30 mins without compromising image quality. These advances have led to novel clinical applications of whole body MRI, including tumour staging. To date, there are no reports which have evaluated the role of this new technique in ALL. ALL is the most common tumour in children accounting for about 30% of all newly diagnosed childhood cancer patients. In Hong Kong, there are approximately 40-50 new ALL patients per year. Whole body MRI provides a means for screening the marrow of the entire skeleton, such that the full extent of disease and treatment complications can be evaluated. This is especially important in haematologic disorders which may be spatially heterogeneous like ALL. In a longitudinal study of children diagnosed with ALL, we aim to determine:1)Whole body MRI patterns at diagnosis and subsequent treatment2)If disease load/extent quantified by whole body MRI will contribute to patient management for treatment monitoring and response prediction3)The role of whole body MRI in the screening of early AVN (secondary aim)We hypothesize that this non-invasive technique will provide complementary information to conventional ways of diagnosis and monitoring treatment response i.e. peripheral blood sampling and bone marrow aspiration.We expect to be able to define the clinical usefulness of whole body MRI in leukemia patients. This method of imaging is increasingly available in MRI scanners and especially advantageous in paediatric patients whereby a non-invasive, fast, one-stop imaging modality is desirable

Project Title:	Diffusion tensor MRI imaging (DTI) of radiation-induced white matter injury in a rat model
Investigator(s):	Khong PL, Wu EX, Cheung PT, Kwong DLW
Department:	Diagnostic Radiology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2007

Abstract:

To test the following hypotheses: (1) diffusion anisotropy quantitative index, fractional anisotropy (FA) is more sensitive than T2 relaxometry in detecting radiation-induced white matter damage; FA and the diffusion tensor matrix components, radial diffusivity and axial diffusivity, correlate with histological findings of radiation-induced injury, namely demyelination; changes in diffusion anisotropy are dose and time dependent and occur in parallel with histological evidence of demyelination; DTI can accurately detect and monitor the degree of demyelination in-vivo and can be used as a biomarker for the non-invasive evaluation of radiation-induced brain injury.

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Researcher : Lam YK

List of Research Outputs

Hui C.L.M., Wong G.H.Y., Lam Y.K., Chow P.P.L. and Chen E.Y.H., Patient-clinician Communication and Needs Identification for Outpatients with Schizophrenia in Hong Kong: Role of the 2-COM Instrument, Hong Kong Journal of Psychiatry. 2008, 18(2): 69-75.

Researcher : Lau SMSM

List of Research Outputs

Chui H.W., Lee A.M., Lau S.M.S.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Family factors, depression and high-risk behaviours among Chinese adolescents in Hong Kong, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chui H.W., Fong D.Y.T., Kwan C.W., Chong C.S.Y. and Tang L.C.H., Prevalence, course and risk factors of disordered eating during pregnancy and in the postpartum period, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chong C.S.Y., Chui H.W. and Fong D.Y.T., Prevalence, course, and risk factors of antenatal anxiety and depression, Obstetrics & Gynecology. 2007, 110 (5): 1102-1112.

Lee A.M., Chan C.L.W., Ho A.H.Y., Wang C.N., Tang Y.H., Lau S.M.S.M., Leung P.P.Y., Fu Y.T., Yau Y.T. and Ho J.W.C., The Efficacy of the Body-Mind-Spirit Intervention Model on improving the quality of life and psychological well-being of Chinese patients with colorectal cancer, Health Research Symposium 2007: Building bridges between research, practice & policy. 2007.

Researcher : Lau WM

List of Research Outputs

Lau W.M., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Differential effect of chronic corticosterone and antidepressant treatment on amygdale cell proliferation and depression-like behavior, Hong Kong Society of Biological Psychiatry Conference 2007, October 18-20, 2007, Hong Kong. 2007, 20 A0007.

Lau W.M., Qiu G., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Neuroprotection in steroid therapy: An animal model, Health Research Symposium 2007: Building bridges between research, practice & policy, HKSAR, PRC . 2007.

Lau W.M., Qiu G., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Neuroprotection in steroid therapy: An animal model, Health Research symposium 2007, September 29, 2007. Poster P10.

You S., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of different doses of corticosterone on hippocampal cell proliferation, Hong Kong Society of Biological Psychiatry Conference 2007, October 18-20, 2007, Hong Kong. 2007, 19 A0006.

Researcher : Lau WM

List of Research Outputs

Researcher : Law ACK

List of Research Outputs

Law A.C.K., One Disease, Many Nations: A discussion on apporaches to Alzheimer's Disease treatment., State Key Laboratory of Brain & Cognitive Sciences, HKU and The University of Paris 7 Denis Diderot. 2008.

Researcher : Law CLP

List of Research Outputs

Tang S.W., Chu E., Hui T.C.K., Helmeste D.M. and Law C.L.P., Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects, Neuroscience Letters. Ireland, 2007 Elsevier Ireland Ltd, 2007, 431: 62-65.

Researcher : Law CW

List of Research Outputs

Chen E.Y.H., Hui C.L.M., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., A double-blind randomized placebo-controlled study of relapse prevention in remitted first-episode psychosis patients following one year of maintenance therapy, Schizophrenia Research. 2008, 98: 11.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Hui C.L.M., Chen E.Y.H., Lam M., Law C.W., Chiu C.P.Y., Chung D.W.S., Tso S., Pang E.P.F., Chan K.T., Wong Y.C., Mo F., Chan K.P.M., Hung S.F. and Honer W.G., Predictors for relapse in a double-blind randomized placebo-controlled discontinuation study of remitted first-episode psychosis patients, Schizophrenia Research. 2008, 98: 13.

Ng R.M.K., Pearson V.J., Lam M., Law C.W., Chiu C.P.Y. and Chen E.Y.H., What Does Recovery From Schizophrenia Mean? Perceptions of Long-Term Patients, International Journal of Social Psychiatry. SAGE Publications, 2008, 54: 118-130.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 181.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 181.

Researcher : Lee AM

Project Title:	Psychosocial Group Therapy for Menopausal Women: A model for the non-pharmacological management of menopausal distress
Investigator(s):	Lee AM
Department:	Psychiatry
Source(s) of Funding:	Centre on Behavioral Health Seed Funding Scheme - General Award
Start Date:	07/2003

Abstract:

The study aims at developing and evaluating the efficacy of a psychosocial group therapy approach to the management of menopausal problems among Hong Kong women.

Project Title:	The efficacy of group psychosocial intervention on psychological distress, quality of life, and post-traumatic growth among patients with gynaecological cancers: a randomized controlled trial
Investigator(s):	Lee AM, Ngan HYS, Chan YM, Tam KF, Lee PWH
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To systematically test the efficacy of group psychosocial intervention in reducing psychological distress, and improving quality of life and adjustment among patients with gynaecological cancers; to examine the usefulness of group psychosocial intervention in bringing about post-traumatic growth among patients with gynaecological cancers; to examine the course of changes in psychological distress, quality of life, and post-traumatic growth over time; to examine the ability of psychological distress in predicting quality of life, adjustment, and post-traumatic growth at post-intervention and three-month follow-up; to identify therapeutic elements of the group psychosocial intervention programme.

Project Title:	A prospective longitudinal study of high-risk behaviors among adolescents in Hong Kong: the effects of modernization and culture
Investigator(s):	Lee AM, Stewart SM, Lam TH, Lee PWH
Department:	Psychiatry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

Obtain baseline information on the rates, forms, and patterns of high-risk behaviors among adolescents in Hong Kong; to empirically test the hypothesis that high-risk behaviors (such as smoking, substance abuse, and early sex) represent a single core construct versus the competing hypothesis that they represent multiple constructs or even distinct and isolated behavioral entities; to identify a set of risk and protective factors that may predispose (or protect) adolescents to (from) high-risk behaviors. These risk factors include individual factors as well as measurable vulnerabilities associated with modernization; to understand the developmental trajectories and causative influences of risk factors identified; to examine the longer term consequences (adverse end-points) of high-risk behaviors in terms of a broad range of mental and physical health problems problems as well as functioning.

Project Title:	An exploratory study of the male climacteric and its relationship with psychological factors
Investigator(s):	Lee AM, Leung SSK, Chen RYL
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

The document the level of ADAM among middle- and old-aged males between the ages of 40 and 80 in Hong Kong; to examine the multidimensional nature of male climacteric problems and its relation to androgen deficiency; to identify the psychological risk factors of male climacteric problems and ADAM; to compare the relative contribution of psychological factors and androgen deficiency to male climacteric problems; to examine the impact of climacteric problems and ADAM on quality of life among males.

Project Title:	A randomized contolled trial of the efficacy of a model of psychosocial intervention in improving quality of life and psychological well-being of Chinese patients with colorectal cancer
Investigator(s):	Lee AM, Chan CLW, Ho JWC
Department:	Psychiatry
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	02/2005

Abstract:

The study uses a prospective randomized controlled trial design to systematically assess the efficacy of an Eastern Body-Mind-Spirit (BMS) approach in improving the quality of life and psychological well-being among a sample of colorectal cancer patients in Hong Kong. Its specific objectives are as follows: (i) To examine the efficacy of BMS intervention in improving quality of life and psychological well-being outcomes among CRC patients against a control group that receives no active psychosocial intervention; (ii) To monitor the effectiveness of BMS intervention over time;

Project Title:	Translation of the Depression Anxiety and Stress Scales 21- item version (DASS-21) into Chinese and Validation of the Chinese DASS-21 among Clinical and Non-Clinical Samples in Hong Kong
Investigator(s):	Lee AM, Wong JGWS, Lam TP, Tang SW
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2006

Abstract:

PURPOSE OF PROPOSED STUDY:The Depression Anxiety Stress Scales (DASS) (1) has been widely evaluated and shown to be a high quality self-report measure of depression, anxiety, and stress. Its unique capacity to define and distinguish between these three negative emotional states renders it a valuable tool in both research and clinical practice. It is superior to traditional measures of depression, most of which are less pure measures of depression by containing a mixture of depressive and anxiety symptoms; the same being true for traditional measures of anxiety (2,3,4). The DASS-21 is a 21-item short version of the DASS with equally satisfactory psychometric properties (1). It has been translated into a number of different languages, and used among diverse populations (5,6). In Hong Kong, where over 95% of the population are ethnic Chinese, and Chinese is the dominant language of communication, a conceptually equivalent and validated Chinese version the DASS-21 is much needed. The proposed study aims to translate the 21-item version of the Depression Anxiety and Stress Scales (DASS-21) into Chinese and validate it among clinical and non-clinical samples of Hong Kong Chinese. Sepcifically, the proposed study purports to use an established and systematic approach to translate the DASS-21 into Chinese, the product of which will be compared to the original English version by testing on bilingual subjects. Its psychometric properties will then be further examined in both clinical and non-clinical samples with regard to reliability (internal consistency and test-retest reliability), factorial validity, concurrent validity, and convergent and discriminant validity. LITERATURE REVIEW AND KEY ISSUES:The Depression Anxiety Stress Scales (DASS) (1) is a 42-item questionnaire developed to measure the three negative emotional states of depression, anxiety, and stress. It is widely used among Caucasian populations for both clinical and research purposes. The DASS-21 is a short version of the DASS, with three subscales each consisting of 7 items to measure the three negative emotional states. The psychometric properties of both the 42-item original version and the 21-item short version have been examined in non-clinical and clinical samples. Reliability in terms of internal consistency and temporal stability is high across the board. Moreover, convergent and discriminant validity as examined by correlation with other self-report measures of depression and anxiety are consistently satisfactory (2,3,7). The DASS and DASS-21 differ from traditional measures in their proven capacity to distinguish well between anxiety and depressive symptoms, and providing a measure of stress at the same time (2,3,4).Developing suitable instruments for assessing depression and anxiety poses great challenge. This is because although depression and anxiety disorders are conceptualized as distinct clinical entities, there is substantial overlap between the two conditions, and they often co-occur clinically (8). Among non-clinical populations, levels of depression and anxiety also correlate significantly and strongly with each other (9). Existing measures of depression and anxiety fare poorly in distinguishing between these two negative emotional states (3).Clark and Watson (10) developed the tripartite model of anxiety and depression in an attempt to explain the overlap between depression and anxiety. They argued that depression and anxiety have both unique and shared characteristics, with the shared component being elevated negative affect such as irritability and general distress. Based on this model, there are three interrelated negative emotional states, namely, anhedonia, physiological arousal, and general distress. Anhedonia or the absence of positive affect is unique to depression, physiological arousal is unique to anxiety, and general distress is common to both depression and anxiety. Within this theoretical framework, only anhedonia and physiological arousal are specific negative emotional states; general distress represents a non-specific component shared by both depression and anxiety . Lovibond and Lovibond (1,7,11) further identified a third specific and distinct negative emotional state, stress, that is distinct from depression and anxiety on the one hand, and differs from the non-specific symptoms shared by both depression and anxiety (general distress) on the other. This negative emotional state relates to general hyperarousal and is characterized by tension, inability to relax, and overreaction to stressful events.The DASS was conceptually and psychometrically consistent with the tripartite model of anxiety and depression but extends beyond it to include a measure of stress. The Depression scale (DASS-D) measures symptoms unique to depression, and includes items that are associated with dysphoria or an absence of positive affect. The Anxiety scale (DASS-A) measures symptoms unique to anxiety, and includes items that assess symptoms of physiological hyperarousal. Studies clarifying the nature of these symptoms found that symptoms on this scale are particularly characteristic of those experienced by patients with panic disorder (2). The Stress scale (DASS-S) includes items measuring symptoms such as tension, irritability, and tendency to overreact to stressful events. The symptoms on the Stress scale, being characteristic symptoms associated with chronic worry, have been found to be most associated with symptoms of Generalized Anxiety Disorder (GAD), a particular form of anxiety disorder (2).The 21-item version has the obvious advantage of being shorter and quicker to administer, hence more suitable as a screening instrument for assessing primary care patients and community population. Clara et al (12) have used a predominantly depressed sample and shown, through confirmatory factor analysis, support for a 3-factor model for the DASS-21 which was not improved by the 42-item version. Furthermore, the 21-item DASS provided clearer distinction between the anxiety and depression symptoms compared with the 42-item DASS. These results point to the value of DASS-21 as the instrument of choice over its 42-item counterpart. A Chinese version of DASS-21 was developed and tested on an Australian immigrant sample by Taouk et al (13). Factor loadings were found to be generally comparable to those reported by Lovibond and Lovibond using the English DASS (1,3), but the discrimination between the depression, anxiety and stress scales was significantly poorer. This study represents only a preliminary validation of the Chinese DASS-21, and the value of this translated measure in the Hong Kong population remains questionable, especially since there are subtle differences in the use of the Chinese language by Chinese in different parts of the world. Data from Chinese-speaking Australian immigrants cannot be readily generalizable to Hong Kong Chinese. Indeed, experience by local clinicians found parts of the scale poorly understood by some patients in Hong Kong. Further study is called for to formally translate the DASS-21 into Chinese, to test the psychometric properties of the Chinese version on a clinical sample, and to perform a more thorough evaluation of its psychometric properties among non-clinical samples of Hong Objectives of Study:This study aims to use a systematic and methodical approach to translate the DASS-21 into Chinese, and to validate it on non-clinical and clinical samples of Hong Kong Chinese. Specifically, the proposed study aims to achieve the following two main objectives:(i) To produce a conceptually and linguistically equivalent Chinese translation of the original English DASS- 21.(ii) To evaluate the psychometric properties of the Chinese DASS-21 among non-clinical and clinical populations in Hong Kong in terms of reliability, factorial validity, convergent and discriminant validity, and concurrent validity.

Project Title:	A multidimensional longitudinal study of disordered eating attitudes and behaviours and its risk factors and outcome among pregnant women
Investigator(s):	Lee AM, Leung KY, Lao TTH, Fong DYT
Department:	Psychiatry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	04/2007

Abstract:

Primary objectives: (1) To test the association of pregnancy-related risk factors (ambivalence towards pregnancy, pregnancy abuse, depression, and anxiety) with disordered eating attitudes and behaviours during pregnancy. (2) To test the association of pre-pregnancy related risk factors (pre-pregnant maladaptive eating attitudes and behaviours, and body dissatisfaction) with disordered eating attitudes and behaviours during pregnancy. Secondary objectives: (3) To establish the prevalence of disordered eating attitudes and behaviors among pregnant women in Hong Kong.

List of Research Outputs

Chu L.W., Tam S., Kung A.W.C., Lam T.P., Lee A.M., Wong R.L.C., Lo S., Fan S., Chung C.P., Morley J.E. and Lam K.S.L., A short version of the ADAM questionnaire for androgen deficiency in Chinese men. , Journal of Gerontology. Series A, Biological Sciences and Medical Sciences . 2008, 63(4): 426-431.

Chui H.W., Lee A.M., Lau S.M.S.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Family factors, depression and high-risk behaviours among Chinese adolescents in Hong Kong, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Moderating effects of family factors on the relationship between traditionality-modernity and high-risk behaviours, Paper presented at the 12th Postgraduate Symposium, Dec 14, 2007, Hong Kong. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Stewart S.M., Lee P.W.H. and Lam T.H., The impact of traditionality and individualism on problem behaviors among Hong Kong adolescents, World Mental Health Conference. 2007.

Lau P.W.C., Lee A.M. and Ransdell L., Parenting Style and Cultural Influences on Overweight Children's Attraction to Physical Activity, Obesity Research. 2007, 15(9): 2293-2302.

Lee A.M., A Prospective Longitudinal Study of High-Risk Behaviors among Adolescents in Hong Kong: The Effects of Modernization and Culture. , Final report submitted to the Research Grants Council. 2008.

Lee A.M., Ho J.W.C. and Chan C.L.W., A randomized controlled trial of the efficacy of a model of psychosocial intervention in improving quality of life and psychological well-being of Chinese patients with colorectal cancer, Health and Health Services Research Fund, the Food and Health Bureau, HKSAR, Apr 30, 2008. 2008.

Lee A.M., Lam T.P., Chong C.S.Y., Chu L.W. and Chan S.Y., A study of androgen deficiency and its relationship with psychological factors in Hong Kong, Poster presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Lee A.M., Depression, Headline Daily (Mar 27, 2008) (HKU LKS Faculty of Medicine column - page 44). 2008.

Lee A.M., Eating Disorders, Metro Daily (Sep 14, 2007) (HKU LKS Faculty of Medicine column). 2007.

Lee A.M., Family's Role in Helping Patients with Alcoholism, Oriental Daily (Aug 5, 2007) (HKU LKS Faculty of Medicine column - page A6). 2007.

Lee A.M., Invited Speaker for "Sexual Well-Being of Asian Menopausal Women" (Hong Kong Association of Sexuality Educators, Researchers and Therapists, Press Conference, Oct 16, 2007). 2007.

Lee A.M., Invited Workshop Speaker for workshop "Eating Disorders and Self-Esteem Problems among Adolescents" (Hospital Authority - Jardines Mindset Health in Mind Youth Mental Health Promotion Programme) October 13, 2007. 2007.

Lee A.M., Positive Cognitions and Exercise in Stress Management, AM730 (Aug 27, 2007) (HKU LKS Faculty of Medicine column - page 5). 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chui H.W., Fong D.Y.T., Kwan C.W., Chong C.S.Y. and Tang L.C.H., Prevalence, course and risk factors of disordered eating during pregnancy and in the postpartum period, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Lee A.M., Lam S.K., Lau S.M.S.M., Chong C.S.Y., Chui H.W. and Fong D.Y.T., Prevalence, course, and risk factors of antenatal anxiety and depression, Obstetrics & Gynecology. 2007, 110 (5): 1102-1112.

Lee A.M., Psychological Aspects of Premenstrual Syndrome, I-cable interview (8:00 pm - 9:00 pm) (May 13, 2008). 2008.

Lee A.M., Psychological Dimensions of Menopausal Symptoms and Its Management, RTHK programme '健康大道' broadcasted on ATV from 7:00 pm to 7:30 pm (Feb 12, 2008). 2008.

Lee A.M., Research Subcommittee member, Family Planning Association. 2008.

Lee A.M., Chan C.L.W., Ho A.H.Y., Wang C.N., Tang Y.H., Lau S.M.S.M., Leung P.P.Y., Fu Y.T., Yau Y.T. and Ho J.W.C., The Efficacy of the Body-Mind-Spirit Intervention Model on improving the quality of life and psychological well-being of Chinese patients with colorectal cancer, Health Research Symposium 2007: Building bridges between research, practice & policy. 2007.

Lee K.Y., Wong G.C.Y., Lee A.M. and Ng M.L., Women's sexuality after termination of pregnancy in Hong Kong Chinese , Hong Kong Practitioner. 2007, 29: 452-462.

Researcher : Lee PWH

Project Title:	A study of risk factors for exposure to AIDS in high risk adolescent Chinese females
Investigator(s):	Lee PWH
Department:	Psychiatry
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/1997

Abstract:

To study the prevailing pattern of knowledge, practice and attitudes towards sexual intimacy and behaviours in teenage secondary school female students; to study common misconceptions and risks of teenage secondary school students towards developing STDs and AIDs; to study factors associated with increased risk for exposure to STDs and AIDs.

Project Title:	Psychological adjustment and stresses of nurses working in acute hospital
Investigator(s):	Lee PWH
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Abstract:

To study the prevalence of psychological malaise in a representative group of registered nurses working in acute general hospital; to identify factors associated with increases stress and strain in registered nurses in acute general hospital.

Project Title:	The psychosocial outcomes and well-being of living related donors involved in liver transplantation surgery: a follow-up study of risk factors, resilience, and outcome predictors
Investigator(s):	Lee PWH, Fan ST, Fung ASM
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To trace the natue and course of psycholsocial adjustment of living related donors through a retrospective study on their adjustment in the pre-transplanation, post-transplantation and rehabilitation phases; to identify areas of concerns, difficulties, physical malaise, and psychosocial distress in donors during the different phases of the transplantation procedure and its rehabilitation; to study the relationship between pre-transplantation variables of the living related donors and their levels of post-transplantation functioning and adjustment; to identify predictors of high-risk characteristics and situations likely to be encountered by living related donors and consider ways of reducing such risks; on the basis of data gathered and analyzed, to consider cost-effective avenues, format and focus of psychosocial interventions to enable potential living related donors to achieve an all round better immediate and long-term outcome; to look into the differences in decision making processes and adjustment of living related donors with different relationship with the recipients.

List of Research Outputs

Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98.

Chui H.W., Lee A.M., Lau S.M.S.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Family factors, depression and high-risk behaviours among Chinese adolescents in Hong Kong, Paper presented at the World Psychiatric Association International Congress 2007, Nov 28 - Dec 1, 2007, Melbourne, Australia. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Lee P.W.H., Stewart S.M. and Lam T.H., Moderating effects of family factors on the relationship between traditionality-modernity and high-risk behaviours, Paper presented at the 12th Postgraduate Symposium, Dec 14, 2007, Hong Kong. 2007.

Chui H.W., Lee A.M., Fong D.Y.T., Stewart S.M., Lee P.W.H. and Lam T.H., The impact of traditionality and individualism on problem behaviors among Hong Kong adolescents, World Mental Health Conference. 2007.

Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232.

Lam C.L.K., Lee P.W.H., Fong D.Y.T. and Lam T.P., A randomised controlled trial on the effectiveness of screening and brief problem-solving counselling for elderly patients with undiagnosed psychological problems in primary care., Hong Kong Medical Journal. HK Academy of Medicine Press, 2008, 14: 31-35.

Lam C.L.K., Lee P.W.H., Fong D.Y.T. and Lam C.L.K., “Screening and Brief Problem-solving Counselling had Short-term Benefit for Elderly Patients with Undiagnosed Psychological Problems in Primary Care”. , Vancourver, Canada , 35th NAPCRG Annual Meeting, October 20-23, 2007.

Lau K.S., Siong K.H., Tang H.Y., Cheng P.W., Cheung K.S., Chan S.W., Lee P.W.H. and Wong J.G.W.S., An innovative web-based peer support system for medical students in Hong Kong, Medical Teacher. 2007, 29: 984-986.

Lee P.W.H., Beliefs about cervical cancer and human papillomavirus (HPV) and acceptability of HPV vaccination among Chinese women in Hong Kong, Preventive Medicine. US, Elsevier Inc., 2007, 45: 130-134.

Lee P.W.H., Living life fully: positive approaches in combating negative emotions, World Federation of Mental Health: 2007 World Mental Health Congress . 2007.

Lee P.W.H., Psychological management of breast cancer : longitudinal considerations , the 6th Biannual Meeting of the Asian Breast Cancer Society:. 2007.

Lee P.W.H., Supporting the needs of women with breast cancer across time, The 6th Biennial Meeting of the Asian Breast Cancer Society, September 20-22, 2007, Hong Kong. 2007.

Lee W., Ho D.S.Y., Stewart S.M., Leung G.M., Lee S., Mak K.H., Lee P.W.H., Wong J.P.S., Striegel-Moore R.H., Fung S.S.W., Lo W.S., Mak K.K. and Lam T.H., Correlates of body image disturbances in Hong Kong Chinese girls and boys (abstract), 2nd International Conference on Child and Adolescent Psychopathology, 5-6 July 2007, London. London, Whitelands College, Roehampton University, 2007, 23.

Lee W., Stewart S.M., Byrne B.M., Wong J.P.S., Ho D.S.Y., Lee P.W.H. and Lam T.H., Factor structure of the center for epidemiological studies depression scale in Hong Kong adolescents, Journal of Personality Assessment. 2008, 90(2): 175-184.

Lee W., Ho D.S.Y., Stewart S.M., Leung G.M., Lee S., Mak K.H., Lee P.W.H., Wong P.S.J., Striegel-Moore R.H., Lo W.S., Mak K.K. and Lam T.H., Relation of early sexual maturation to body image disturbance and depressive symptoms in Hong Kong Chinese girls and boys: A prospective study (abstract and oral presentation), 12th Research Postgraduate Symposium, 12 & 14 December 2007, Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2007, 148.

Lee W., Stewart S.M., Striegel-Moore R.H., Lee S., Ho D.S.Y., Lee P.W.H., Katzman M.A. and Lam T.H., Validation of the eating disorder diagnostic scale for use with Hong Kong adolescents, International Journal of Eating Disorders. 2007, 40: 569-574.

Mok P.W.K., Wong W.H.S., Lee P.W.H. and Low L.C.K., Is Teenage Obesity Associated with Depression and Low Self-Esteem?: A Pilot Study, Hong Kong Journal of Paediatrics. 2008, 13: 30-38.

Ngan H.Y.S., Kwan T.T.C., Tam K.F., Chan K.K.L., Young P.M., Lo S.S., Cheung A.N.Y. and Lee P.W.H., Knowledge and attitute of Chinese women on cervical cancer and human papillomavirus, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007.

Wong P.S.J., Stewart S.M., Claassen C.A., Lee P.W.H., Rao U. and Lam T.H., Repeat suicide attempts in Hong Kong community adolescents, Social Science & Medicine. 2008, 66: 232-241.

Researcher : Lee TMC

Project Title:	Memory deficits following unilateral frontal or temporal brain lesion
Investigator(s):	Lee TMC, Fan YW
Department:	Psychology
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	05/2000

Abstract:

To develop an instrument for assessment of confabulation in prose memory.

Project Title:	Deception and its detection: brain activities associated with faking memory problems
Investigator(s):	Lee TMC, Broadhurst RG, Yang ES
Department:	Psychology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2002

Abstract:

The project attempts to investigate the potential application of brain activities to understand the phenomenon of deception and its detection. It will examine the generalizability of forced-choice testing situations, and also different brain activities associated with making genuine errors and feigning memory impairment.

Project Title:	Selective attention biases of people with major depressive disorder, and its relationship with brain damages.
Investigator(s):	Lee TMC, Leung KK
Department:	Psychology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Attention bias towards mood-congruent information has been postulated to be one of the essential psychological substrates of major depressive disorder. Attention biases could have at least two levels of meanings: a) initial orienting, i.e. attention being captured involuntarily to certain types of information; and b) difficulties in inhibiting or shifting the attention from the current attentional focus once certain types of information has been attended to, either voluntarily or involuntarily. However, research findings are inconsistent in demonstrating these phenomena in people with major depressive disorder. This study aims to investigate whether people with major depressive disorder exhibit these two types of attention biases. In addition, it has been postulated that major depressive disorder is associated with frontal-limbic dysregulation. In particular, various studies suggest that amygdala, prefrontal cortex, anterior cingulate cortex, and hippocampus are involved in depression. This study also attempts to investigate whether people with brain lesions arising from stroke or brain trauma at the above areas also exhibit the attention biases to depression-related information. It also follows that question of whether those who show these attention biases due to brain lesions also exhibit depressive features will also be examined.

Project Title:	Brain processes underlying deception
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2007

Abstract:

The purpose of this study is to understand the neuroscientific mechanisms and the pattern of brain activities associated with the faking of memory impairment. In recent years, we have been working on delineating the cognitive processes and on possible neural markers for feigning memory impairment. Our preliminary findings, together with data obtained by other research teams, have suggested possible markers of deceptive behaviors. Nonetheless, simple experimental tasks were adopted in these functional magnetic resonance imaging (fMRI) studies to control for the unwanted confound introduced by task difficulty. One serious limitation of the findings is that the observed different brain activities between honest correct answers to tasks of low level of difficulty and feigned errors (which required mental effort) could be due to the difference in cognitive load of the two conditions. It is therefore informative to compare feigned errors with honest responses, correct or not, caused by a more challenging task to learn if feigning behavior could be identified using functional imaging technology. We therefore proposed this study, with increased task difficulty that encourages the occurrence of errors, to study if errors committed when people attempt to respond honestly can be distinguished from intentionally faked responses. The Key Objectives: 1. To identify the pattern of brain activities that best differentiates accurate honest versus intentionally faked responses. We anticipate activation of the prefrontal-cingulate-parietal areas based on the findings of previous studies. 2. To identify the pattern of brain activities that best differentiates (a) genuine errors versus faked response and (b) false memory (a subset of genuine errors) versus intentionally faked responses. We speculate that different brain activities will be observed in the medial temporal regions known for mediating memory, accurate as well as false memory.

Researcher : Leung MK

List of Research Outputs

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

Researcher : Leung MK

List of Research Outputs

Researcher : Li Q

List of Research Outputs

Li Q. and Yew D.T., A Review of the Dopamine System in the Animal Models of Attention-deficit Hyperactivity Disorder, NOVA. 2008.

Li Q., Zhang L., Forster E.L. and Yew D.T., Dementia in the middle aged in China, Alzheimer's Disease in the Middle-Aged. Nova Science Publishers, Inc, 2008.

Li Q., Sp W., Wp L., Dt Y. and McAlonan G.M., Ketamine abuse and apoptosis in the cortex in monkeys and mice, The International Journal of Neuropsychopharmacology. 2008, 11: 236.

Researcher : Mak KY

Project Title:	Program enhancement for the mental-ill patients at the S.K. Yee Mental Health Resource and Rehabilitation Centre
Investigator(s):	Mak KY, Wong MMC, Mak-Lieh F, Yau EFY
Department:	Psychiatry
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2000

Abstract:

To facilitate psychiatric patients to return to work and re-integrate into society through widening the present service scope by providing sufficient equipment to meet the increasing demand in work training and offer wider range of therapeutic programs to improve the domestic living skill of patients; to provide professional development and training to psychiatrists and paramedical staff in Hong Kong and China.

Researcher : McAlonan GM

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Chua S.E., Deng Y., Chen E.Y.H., Law C.W., Chiu C.P.Y., Cheung C., Wong J.C.H., Lienenkaemper N., Cheung V., Suckling J. and McAlonan G.M., Early striatal hypertrophy in first-episode psychosis within three weeks of initiating antipsychotic drug treatment, Psychological Medicine. 2008, 1-8.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naive, newly diagnosed schizophenia, Schizophrenia Research. 2008, 98: 38.

Deng Y., Merali H.S., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Early evidence of cerebral grey matter voulume changed after treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 38.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., GREY MATTER VOLUME INCREASE AFTER EARLY ANTIPSYCHOTIC TREATMENT IN DRUG NAÏVE, FIRST EPISODE SCHIZOPHRENIC COHORT., NeuroImage. 2008, 41: s82.

Deng Y., McAlonan G.M., Merali H., Cheung C., Cheung V., Chen E.Y.H. and Chua S.E., Grey matter volume increase after early antipsychotic treatment in drug naïve, first episode schizophrenic cohort, NeuroImage. 2008, 41(S1): 203.

Deng Y., McAlonan G.M., Merali H.S., Cheung C., Chen E.Y.H., Cheung V. and Chua S.E., Matter volume increase after early antipsychotic treatment in drug naive, first episode schizophrenic cohort, 14th Annual Meeting Human Brain Mapping, Melbourne, Australia, June 15-19, 2008.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., EFFECT OF EARLY ANTIPSYCHOTIC TREATMENT ON CAUDATE AND AMYGDALA VOLUME IN NEUROLEPTIC NAÏVE, NEWLY DIAGNOSED SCHIZOPHRENIA , NeuroImage. 2008, 41: s83.

Leung M.K., Chua S.E., Merali H., Deng Y., Cheung C., Cheung V., Chen E.Y.H. and McAlonan G.M., Effect of Early Antipsychotic Treatment on Caudate and Amygdala Volume in Neuroleptic Naïve, Newly Diagnosed Schizophrenia, NeuroImage. 2008, 41(S1): 219.

Li Q., Sp W., Wp L., Dt Y. and McAlonan G.M., Ketamine abuse and apoptosis in the cortex in monkeys and mice, The International Journal of Neuropsychopharmacology. 2008, 11: 236.

McAlonan G.M., King's College/HKU Fellowship for collaborative study on brain biology in autism. 2008.

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, Schizophrenia Research. 2008, 98: 128.

Merali H.S., Deng Y., Cheung C., Chen E.Y.H., Cheung V., McAlonan G.M., Chua S.E. and Chua S.E., Grey matter excess in basal ganglia after early treatment in neuroleptic naive, newly diagnosed schizophrenia, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 128.

Researcher : Ng ML

Project Title:	Chaos in psychotherapy
Investigator(s):	Ng ML
Department:	Psychiatry
Source(s) of Funding:	Department of Psychiatry - General Award
Start Date:	09/1998

Abstract:

To look for chaos patterns in the communication procedures in psychotherapy using mathematical or physical modelling.

Project Title:	Violence on male genitalia - a ten year review of cases in Hong Kong
Investigator(s):	Ng ML
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/2002

Abstract:

To review and investigate into the demographic, psychological and social characteristics of the victims and the offenders involved in cases of violent male genital injury in the last ten years in Hong Kong.

List of Research Outputs

Lee K.Y., Wong G.C.Y., Lee A.M. and Ng M.L., Women's sexuality after termination of pregnancy in Hong Kong Chinese , Hong Kong Practitioner. 2007, 29: 452-462.

Researcher : Ran M

Project Title:	A long-term prospective follow-up study of suicide among persons with affective disorders in a chinese rural area
Investigator(s):	Ran M, Chan CLW, Yip PSF, Chen EYH
Department:	Social Sciences Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To explore the characteristics of suicide among 196 individuals with affective disorders in a 10-year prospective follow-up study in a Chinese rural community.

Researcher : Sham PC

Project Title:	An association screen for schizophrenia susceptibility loci in a high-LD, gene-rich region of chromosome 3p
Investigator(s):	Sham PC
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	07/2004

Abstract:

To identify novel susceptibility loci for schizophrenia, by conducting a high-density SNP screen of a region recently identified by a meta-analysis of 20 genome-wide linkage scans.

Project Title:	A systematic screen for schizophrenia susceptibility loci in high-LD, gene-rich chromosomal regions implicated by meta-analysis of whole genome linkage scans
Investigator(s):	Sham PC, Chen RYL, Ng KP
Department:	Psychiatry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2006

Abstract:

To identify novel susceptibility loci for schizophrenia, by conducting a high-density SNP screen of a number of chromosomal regions that are (a) identified as linkage hotspots by a recent meta-analysis of 20 genome-wide scans of schizophrenia, (b) gene-rich and (c) high in the level of linkage disequilibrium (LD). Optimal marker sets that tag all common variation in these regions will be selected using HapMap data on the Chinese population. These regions will be screened in 489 cases of DSM-IV schizophrenia and 520 controls recruited from Hong Kong; significant associations will be replicated on 500 cases and both parents recruited from Chengdu.

Project Title:	Optimal design of genome-wide association studies for multifactorial diseases
Investigator(s):	Sham PC, Ng MKP, Tang NLS
Department:	Psychiatry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2007

Abstract:

To focus on the following issues in the design of genome-wide association studies: (1) multi-stage, multi-platform study designs; (2) function-informed selection of tag SNPs and haplotype tagging; to quantitative evaluation of subject informativeness; marker-based derivation of homogeneous sub-populations.

List of Research Outputs

Andreou P., Neale B.M., Chen W., Christiansen H., Gabriels I., Heise A., Meidad S., Muller U.C., Uebel H., Banaschewski T., Manor I., Oades R., Roeyers H., Rothenberger A., Sham P.C., Steinhausen H.C., Asherson P. and Kuntsi J., Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects., Psychological Medicine. 2007, 37: 1703-1715.

Ao S.I., Ng M.K. and Sham P.C., Constrained unidimensional scaling with application to genomics., Computational Statistics & Data Analysis. 2007, 52: 201-210.

Chan Y.K., Ching C.Y.J., Xu M.S., Cheung A.N.Y., Yip S.P., Lam L.Y.C., Lai S.T., Chu C.M., Wong A.T.Y., Song Y., Huang F., Liu W., Chung P.H., Leung G.M., Chow E.Y.D., Chan E.Y.T., Chan J.C.K., Ngan H.Y.S., Tam P.K.H., Chan L.C., Sham P.C., Chan V.S.F., Peiris J.S.M., Lin S.C.L. and Khoo U.S., Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome, The Journal of Infectious Diseases. 2007, 196: 271-280.

Cherny S.S., Garcia-Barcelo M.M., Tang S.M., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung’s disease, 38th Annual meeting of the Behavior Genetics Association (abstract appears in Volume 38 of Behavior Genetics). 2008, 38.

Cheung B.M.Y., Ong K.L., Leung Y.H., Wong Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study. , J Hum Hypertens. . 2007, [Epub ahead of print].

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Age-related changes versus degenerative disc disease. World Forum for Spine Research, World Forum for Spine Research - The Intervertebral Disc. Kyoto, Japan, January 23-26, 2008. . 2008.

Cheung K.M.C., Song Y., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007.

Ferreira M.A.R., Sham P.C., Daly M.J. and Purcell S., Ascertainment through family history of disease often decreases the power of family-based association studies., Behavior Genetics. 2007, 37: 631-636.

Fogh L., Rijsdijk F., Andersen P.M., Sham P.C., Knight J., Neale B., McKenna-Yasek D., Silani V., Brown R.H., Powell J.F. and Al-Chalabi A., Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality., Neurogenetics. 2007, 8: 235-236.

Frazer K.A., Ballinger D.G., Cox D.R., Hinds D.A., Stuve L.L., Gibbs R.A., Belmont J.W. and Sham P.C., A second generation human haplotype map of over 3.1 million SNPs., Nature. 2007, 449: 851-U853.

Garcia-Barcelo M.M., Tang S.M., Cherny S.S., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung's disease, 57th Annual Meeting of the American Society of Human Genetics. 2007.

He Q., Zhu R., Lei T., Ng M.Y.M., Luk J.M.C., Sham P.C., Lau G. and Chiu J., Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma, Journal of Cellular Biochemistry. 2008, 103: 740-752.

Ho D.W.H., Chan D., Cheung K.M.C., Sham P.C. and Song Y., Family-base linkage and case control association studies, Current Orthopaedics. 2008, 22: 245-250.

Ho D.W.H., Cheung K.M.C., Chan D., Cheah K.S.E., Karppinen J., Sham P.C. and Song Y., LINKAGE ANALYSIS WITH SUBSEQUENT FINE-MAPPING ON FAMILIAL EARLY ONSET-DEGENERATIVE DISC DISEASE, SpineWeek 2008, Geneva, SWITZERLAND. 2008.

Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S...P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early-onset degenerative disc disease. World Forum for Spine Research., The Intervertebral Disc. Kyoto, Japan, January 23-26, 2008.. 2008.

Ho D.W.H., Cheung K.M.C., Chan D., Cheah K.S.E., Karppinen J., Sham P.C. and Song Y., Linkage analysis with subsequent fine-mapping on familial early onset-degenerative disc disease., Spine Week 2008, Geneva, May 26-31, 2008.

Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of the CACNA2D2 gene on chromosome 3p21 as a novel susceptibility gene for osteoporosis, 29th Annual Meeting of the American Society for Bone and Mineral Research. 2007, 22(suppl): M282.

Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S...P., Cheah K.S.E., Song Y. and Sham P.C., Genome-wide association study of degenerative disc disease (DDD)., Spine Week 2008, Geneva, May 26-31, 2008. . 2008.

Kao P.Y.P., Chan D., Cheah K.S.E., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S...P., Song Y. and Sham P.C., Genome-wide association study of degenerative disc disease (DDD)., World Forum for Spine Research - The Intervertebral Disc. Kyoto, Japan, January 23-26, 2008.. 2008.

Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y., Sham P.C. and Sham P.C., Genome-wide association study of degenerative disc disease, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008.

Lee P.Y., Leung K.W., Cheung N., Lam B.Y., Xu Z., Sham P.C., Lau G., Poon R.T.P., Fan S.T. and Luk J.M.C., Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma, Proteomics. 2008, 8(10): 2136-2149.

Li M., Jiang L., Ho S.L., Song Y. and Sham P.C., IGG: A tool to integrate GeneChips for genetic studies. , Bioinformatics. 2007, 23(22): 3105-3107.

Luk J.M.C., Lam B.Y.H., Lee P.Y., Ho D.W.Y., Sham P.C., Chen L., Peng J.R., Leng X.S., Day P.J. and Fan S.T., Artificial neural networks and decision tree model analysis of liver cancer proteomes, Biochemical and Biophysical Research Communications. 2007, 361(1): 68-73.

Neale B.M., Sham P.C., Purcell S., Banaschewski T., Buitelaar J., Franke B., Sonuga-Barke E., Ebstein R., Eisenberg J., Mulligan A., Gill M., Manor L., Miranda A., Mulas F., Oades R.D., Roeyers H., Rothenberger A., Sergeant J., Steinhausen H.C., Taylor E., Thompson M., Zhou K., Asherson P. and Faraone S.V., Population differences in the International Multi-Centre ADHD Gene project., Genetic Epidemiology. 2008, 32: 98-107.

O'Gara C., Knight J., Stapleton J., Luty J., Neale B., Nash M., Heuzo-Diaz P., Hoda F., Cohen S., Sutherland G., Collier D., Sham P.C., Ball D., McGuffin P. and Craig L., Association of the serotonin transporter gene, neuroticism and smoking behaviours., Journal of Human Genetics. 2008, 53: 239-246.

Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of F11 receptor gene polymorphisms with central obesity and blood pressure, J Intern Med.. 2008, 263: 322-32.

Ong K.L., Leung Y.H., Wong L.Y.F., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens. 2008, 21: 539-45.

Proitsi P., Li T., Hamilton G., Di Forti M., Collier D., Killick R., Chen R., Sham P.C., Murray R., Powell J. and Lovestone S., Positional pathway screen of wnt signaling genes in schizophrenia: Association with DKK4., Biological Psychiatry. 2008, 63: 13-16.

Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A.R., Bender D., Maller J., Sklar P., de Bakker P.I.W., Daly M.J. and Sham P.C., PLINK: A tool set for whole-genome association and population-based linkage analyses., American Journal of Human Genetics. 2007, 81: 559-575.

Saunders C.L., Chiodini B.D., Sham P.C., Lewis C.M., Abkevich V. and Adeyemo AA D.E. .A.M., Meta-analysis of genome-wide linkage studies in BMI and obesity., Obesity. 2007, 15: 2263-2275.

Simpson C.L., Hysi P., Bhattacharya S.S., Hammond C.J., Webster A., Packham C.S., Sham P.C. and Rahi J.S., The roles of PAX6 and SOX2 in myopia: Lessons from the 1958 British birth cohort., Investigative Ophthalmology & Visual Science. 2007, 48: 4421-4425.

Song Y., Ho D.W.H., Karppinen J., Kao P.Y.P., Fan B.J., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C., Chan D. and Cheung K.M.C., Association between promoter-1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese, BMC Medical Genetics. 2008, 9(1): 38.

Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration in Asians, American Journal of Human Genetics. 2008, 82(3): 744-747.

Song Y., Huang Y., Liu D., Kwan J.S.H., Zhang F., Sham P.C. and Tang S.W., Depression in college: depressive symptoms and personality factors in Beijing and Hong Kong college freshmen, Comprehensive Psychiatry. 2008, 49: 496-502.

Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Genetic Risk Factors For Intervertebral Disc Degeneration, 7th Pan Pacific Connective Tissue Societies Symposium 2007 - Shangri-La Resort, Cairns, Australia, 28 October - 1 November 2007.

Song Y., Sham P.C., Cheung K.M.C. and Chan D., Genetics of disc degeneration, Current Orthopaedics. 2008, 22: 259-266.

Song Y., Chan D., Kao P.Y.P., Ho D.W.H., Fan B., Karpinen J., Yip S...Y., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Cheung K.M.C., Three genes in the aggrecan degradation pathway act synergistically to predispose to degenerative disc disease., World Forum for Spine Research - The Intervertebral Disc. Kyoto, Japan, January 23-26, 2008.. 2008.

Tam P.K.H., Tang S.M., Garcia-Barcelo M.M., Cherny S.S. and Sham P.C., Genome-wide association analysis of Hirschsprung's disease, The 9th International Meeting on Human Genome Variation and Complex Genome Analysis. 2007.

Tomlinson I.P., Webb E., Carvajal-Carmona L., Broderick P., Howarth K., Pittman A.M., Spain S., Lubbe S., Walther A., Sullivan K., Jaeger E, Fielding S, Rowan A, C.O.R.G.I. .C.O.N.S., Ho J.W.C., cheng K.K. and Sham P.C., Luk J.M.C., Dunlop M.G., Houlston R.S., A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3, Nature Genetics. 2008, 40: 623-630.

Toulopoulou T., Picchioni M., Rijsdijk F., Hau-Hall M., Ettinger U., Sham P.C. and Murray R., Substantial genetic overlap between neurocognition and schizophrenia - Genetic modelling in twin samples, Archives of General Psychiatry. 2007, 64: 1348-1355.

Tso A.W.K., Xu A., Sham P.C., Wat N.M.S., Wang Y., Fong C.H., Cheung B.M.Y., Janus E.D. and Lam K.S.L., Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort, Diabetes Care. 2007, 30: 2667-72.

Vermeulen S., Den Heijer M., Sham P.C. and Knight J., Application of multi-locus analytical methods to identify interacting loci in case-control studies, Annals of Human Genetics. 2007, 71: 689-700.

Wang Y., Fong P.Y., Leung F.C.C., Mak W. and Sham P.C., Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome, Genetics and Molecular Research. 2007, 6: 1131-1141.

Xu J.Y., Sham P.C., Xu A.M., Tso A.W.K., Wat N.M.S., Cheng K.Y., Fong C.H.Y., Janus E.D. and Lam K.S.L., Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study., Clinical Endocrinology. 2007, 66: 211-217.

Yang B.R., Chan R.C.K., Jing J., Li T., Sham P.C. and Chen R.Y.L., A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder., American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2007, 144B: 541-550.

Yang W., Sham P.C., Wang Z., Wang L., Huang P. and Lau Y.L., Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies , European Journal of Human Genetics. 2008, doi:10.1038/ejhg.2008.116: 1-9.

Researcher : So KF

Project Title:	Molecular signaling of PKR/EiF2-[alpha] and GSK3[beta] in the pathophysiology of glaucoma
Investigator(s):	So KF, Hugon J, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

N/A

Project Title:	Neuroprotection in steroid therapy: an animal model
Investigator(s):	So KF, Lee TMC, Tang SW
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2005

Abstract:

To investigate the effect of Lithium and paroxetine in arresting hippocampal damages associated with high dosage of steroid through quantitative neuro-anatomical and immunohistochemical methods.

Project Title:	Nanobiomedical manufacturing: the workforce of tomorrow
Investigator(s):	So KF, Ellis-Behnke RG, Tay DKC, Liang Y
Department:	Anatomy
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	09/2006

Abstract:

The goal is to not only understand the variation in the manufacturing process, but to understand how to remove that variation. At the same time the process needs to be optimized for cost, purity and the quantities that will be needed for use in humans.

Project Title:	Hemostasis and Hong Kong: The future hub of Nanomedicine
Investigator(s):	So KF, Ellis-Behnke RG, Liang Y, Tay DKC
Department:	Anatomy
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	09/2006

Abstract:

In order to progress the work to humans we need to perform four additional experiements: 1. Identify the mechanism of action 2. Perform large animal trials in pigs with a liver laceration model 3. Determine the best way to measure the quality of the material during manufacturing 4. Follow up the breakdown of the material by radio labeling the material in the brain and liver

Project Title:	The role of endothelin-1 in chronic ocular hypertension and retinal ischemia-reperfusion
Investigator(s):	So KF, Chung SK
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2007

Abstract:

Glaucoma is an ocular degenerative disease and characterized by progressive damage of optic nerve fibers and retinal ganglion cells (RGC), resulting in progressive visual field loss and excavation of the optic nerve head. As a leading cause of blindness worldwide, glaucoma continues to be a clinical problem. Optic nerve damage in most forms of glaucoma is commonly associated with increased intraocular pressure (IOP) caused by impairment in the normal aqueous humor outflow pathway. Yet, increased IOP may not be the sole risk factor for glaucomatous disease, and because the eye is a highly perfused organ, the vascular system may also play a key role in disease progression. Indeed, death of RGC is thought to be initiated after ischemia resulting from a prolonged vasoconstriction and/or vasospasms from abnormal auto-regulation of the retinal microcirculation. Recent experimental evidence suggests that endothelin-1 (ET-1), a potent vasoconstrictor, may be an important contributor to glaucoma pathophysiology. Studies indicate that perfusion instability, resulted from a disturbed auto-regulation in the context of a general vascular dysregulation, might contribute to glaucoma. Indeed, ET-1 levels in the aqueous humor and plasma are higher in patients with primary open-angle glaucoma. Both vascular (endothelial) and glial (astrocytic) ET-1 are involved in the regulation of retinal micro-circulation; yet, the involvement of these two components in pathophysiology of glaucoma retinopathy is poorly understood. Transient ischemia-related diseases, such as central retinal artery occlusion, angle-closure glaucoma and carotid artery disease, also affect vision. Various methods, such as raising the IOP through cannulation of the eye and ligation of the central retinal artery together with the optic nerve, have been used to create a model of retinal ischemia-reperfusion, but they have drawbacks and limitations. In light of this, we decided to investigate the contribution of vascular and glial ET-1 to the pathogenesis of glaucoma and retinal ischemia-reperfusion using animal models. As validation and interpretation of the published data on human studies are difficult, animal systems may provide insights into exploring the underlying molecular mechanisms of development of glaucoma. Dogs and rats have provided valuable information on the pathogenesis of experimental glaucoma in the form of ocular hypertension, but they are poorly suited for these studies using modern methods of genetic manipulations. Building on our longstanding expertise in studies using transgenic mice, we propose to use transgenic mouse models to study the involvement of ET-1 in retinal structural and functional lesions in ocular hypertension. With the availability of the Tie1-ET-1 (TET-1) and GFAP-ET1 (GET-1) transgenic mice that we generated, we plan to use these animals in our experiments proposed below. The TET-1 mice over-express ET-1 in the endothelial cells under the control of the tie-1 promoter whereas the GET-1 mice carry a transgene in which ET-1 expression is targeted by the GFAP promoter to the astrocytes and Muller cells. Here, we propose to challenge these two lines of transgenic mice to ocular hypertension and assay for retinal structural lesions and functional deficits. In addition, we will challenge these mice with middle cerebral artery occlusion (MCAO) using the intraluminal method, a well established model that is shown to result in retinal ischemia. In so doing, we will be able to investigate the differential contribution of vascular and glial ET-1 in experimental glaucoma and retinal ischemia-reperfusion. Our approach is outlined as follows: 1.To determine the expression of ET-1 and its related genes in chronic ocular hypertension and retinal ischemia-reperfusion. 2.To determine the effects of vascular ET-1 and glial ET-1 in retinal development using transgenic mouse models. 3.To determine the effects of vascular ET-1 and glial ET-1 in ocular hypertension and retinal ischemia-reperfusion. 4.To understand the underlying mechanism behind the observed effects of endothelial and astrocytic ET-1 in chronic ocular hypertension and retinal ischemia-reperfusion using proteomics analyses

List of Research Outputs

Lau W.M., Qiu G., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Neuroprotection in steroid therapy: An animal model, Health Research Symposium 2007: Building bridges between research, practice & policy, HKSAR, PRC . 2007.

Researcher : Song Y

List of Research Outputs

Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98.

Song Y., Huang Y., Liu D., Kwan J.S.H., Zhang F., Sham P.C. and Tang S.W., Depression in college: depressive symptoms and personality factors in Beijing and Hong Kong college freshmen, Comprehensive Psychiatry. 2008, 49: 496-502.

Song Y., Zhou D., Guan Z. and Wang X., Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China, Neuroimmunomodulation. 2007, 14-5: 248-254.

Song Y., Zhou D. and Wang X., Increased serum cortisol and growth hormone levels in earthquake survivors with PTSD or subclinical PTSD, Psychoneuroendocrinology. 2008, 33: 1155-1159.

Researcher : Tai KS

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in ADHD: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research: Neuroimaging. 2008, 154-2: 171-180.

Researcher : Tang SM

List of Research Outputs

Cherny S.S., Garcia-Barcelo M.M., Tang S.M., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung’s disease, 38th Annual meeting of the Behavior Genetics Association (abstract appears in Volume 38 of Behavior Genetics). 2008, 38.

Garcia-Barcelo M.M., Tang S.M., Cherny S.S., Sham P.C. and Tam P.K.H., Genome-wide association study of Hirschsprung's disease, 57th Annual Meeting of the American Society of Human Genetics. 2007.

Tam P.K.H., Tang S.M., Garcia-Barcelo M.M., Cherny S.S. and Sham P.C., Genome-wide association analysis of Hirschsprung's disease, The 9th International Meeting on Human Genome Variation and Complex Genome Analysis. 2007.

Researcher : Tang SW

List of Research Outputs

Lau W.M., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Differential effect of chronic corticosterone and antidepressant treatment on amygdale cell proliferation and depression-like behavior, Hong Kong Society of Biological Psychiatry Conference 2007, October 18-20, 2007, Hong Kong. 2007, 20 A0007.

Lau W.M., Qiu G., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Neuroprotection in steroid therapy: An animal model, Health Research Symposium 2007: Building bridges between research, practice & policy, HKSAR, PRC . 2007.

Lau W.M., Qiu G., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Neuroprotection in steroid therapy: An animal model, Health Research symposium 2007, September 29, 2007. Poster P10.

Lee T.M.C., Ng E.H.H., Tang S.W. and Chan C.C.H., The effects of a sad mood on facial emotion recognition in Chinese people, Psychiatry Research. 2008, 159: 37-43.

Song Y., Huang Y., Liu D., Kwan J.S.H., Zhang F., Sham P.C. and Tang S.W., Depression in college: depressive symptoms and personality factors in Beijing and Hong Kong college freshmen, Comprehensive Psychiatry. 2008, 49: 496-502.

Tang S.W., Chu E., Hui T.C.K., Helmeste D.M. and Law C.L.P., Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects, Neuroscience Letters. Ireland, 2007 Elsevier Ireland Ltd, 2007, 431: 62-65.

You S., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of different doses of corticosterone on hippocampal cell proliferation, Hong Kong Society of Biological Psychiatry Conference 2007, October 18-20, 2007, Hong Kong. 2007, 19 A0006.

Researcher : Tsui WJC

List of Research Outputs

Chu L.W., Tam S., Lee P.W.H., Wong L.C., Yik P.Y., Tsui W.J.C., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men, Clin Endocrinol (Oxf). 2008, 68: 589-98.

Researcher : Wong GHY

List of Research Outputs

Hui C.L.M., Wong G.H.Y., Lam Y.K., Chow P.P.L. and Chen E.Y.H., Patient-clinician Communication and Needs Identification for Outpatients with Schizophrenia in Hong Kong: Role of the 2-COM Instrument, Hong Kong Journal of Psychiatry. 2008, 18(2): 69-75.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Ideas/delusions of reference: development and validation of a new rating scale, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Social anxiety and ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 182.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, Schizophrenia Research. 2008, 98: 181.

Wong G.H.Y., Chiu C.P.Y., Law C.W. and Chen E.Y.H., Themes and prevalence of ideas/delusions of reference in early psychosis, XIVth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Feb 3-7, 2008, Montreux, Switzerland. 2008, 98: 181.

Researcher : Wong JGWS

Project Title:	What makes a good clinical teacher in the new medical curriculum? A focus group study on student perception
Investigator(s):	Wong JGWS, Lam TP, Mak-Lieh F
Department:	Psychiatry
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/2002

Abstract:

To examine medical student perceptions on what makes a good clinical teacher; to explore the concept of a good role model.

Project Title:	A follow-up study on the severity of psychological sequelae in SARS patients
Investigator(s):	Wong JGWS, Sham PC, Wong PC, McAlonan GM, Chu CM, Lee AM, Lee PWH, Tsang KWT, Chua SE
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To assess severity of psychological sequelae in SARS patients (including infected HCWS after recovery from the infection; to assess severity of psychological sequelae in high risk and low risk HCWs after the SARS outbreak; to inform psychological intervention in the event of a future outbreak.

List of Research Outputs

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A DTI study of structural dysconnectivity in never-medicated, first-episode schizophrenia, Psychological Medicine. 2008, 38: 877-885.

Cheung V., Cheung C., McAlonan G.M., Deng Y., Wong J.G.W.S., Yip L., Tai K.S., Khong P.L., Sham P.C. and Chua S.E., A diffusion tensor imaging study of structural dysconnectivity in never-medicated first-episode schizophrenia. , Psychological Medicine. 2008, 38: 877-885.

Lau K.S., Siong K.H., Tang H.Y., Cheng P.W., Cheung K.S., Chan S.W., Lee P.W.H. and Wong J.G.W.S., An innovative web-based peer support system for medical students in Hong Kong, Medical Teacher. 2007, 29: 984-986.

Researcher : Wong MMC

Project Title:	Enrichment of collections in the library of the S.K. Yee Mental Health Resources and Rehabilitation Centre
Investigator(s):	Wong MMC, Mak KY, Mak-Lieh F, Yau EFY
Department:	Psychiatry
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2001

Abstract:

Taking care of mentally people in the community is often a great stress to the caregivers (including family members and staff of those agencies which are involved in the rehabilitation of the patients in the community). They often lack the knowledge in mental illness and are not equipped with the skills in taking care of the mentally ill patients. Therefore apart from offering services to the patients, the service should be extended to cover the caregivers. They should have easy access to information (including written and audio-visual material) so that they can have better knowledge on mental illness and can learn the skills in taking care of the mentally ill patients. It is also important to help the public to change their attitude towards the mentally ill through various public education materials which improve their awardness, understanding and acceptance of mental illness in the community.

List of Research Outputs

Chung K.F., Tso K.F., Wong M.M.C. and Chung T.Y., Validity of the Mood Disorder Questionnaire (MDQ) in the general population in Hong Kong, 3rd Biennial Conference of the International Society for Bipolar Disorders, India, January 28-29, 2008.

Researcher : Yeung WF

List of Research Outputs

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial of Acupuncture for Primary Insomnia, 12th Research Postgraduate Symposium, the University of Hong Kong, Li Ka Shing Facutly of Medicine, Hong Kong, Dec 12 & 14, 2007.

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., Acupuncture for Primary Insomnia: A Randomized Placebo-Controlled Trial, T.W.G.H.S. Eddie Wang Symposium on Integrated Chinese and Western Medicine, Hong Kong, Nov 2-3, 2007.

Researcher : Yu GKK

List of Research Outputs

Lee A.C.K., Tang S.W., Yu G.K.K. and Cheung R.T.F., The incidence and predictors of Depression After Stroke. , International Journal of Psychiatry in Clinical Practice.. 2007, 11: 200-206.

Researcher : Zhang SP

List of Research Outputs

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial of Acupuncture for Primary Insomnia, 12th Research Postgraduate Symposium, the University of Hong Kong, Li Ka Shing Facutly of Medicine, Hong Kong, Dec 12 & 14, 2007.

Yeung W.F., Chung K.F., Zhang S.P., Yap T.G. and Chan Y.P., Acupuncture for Primary Insomnia: A Randomized Placebo-Controlled Trial, T.W.G.H.S. Eddie Wang Symposium on Integrated Chinese and Western Medicine, Hong Kong, Nov 2-3, 2007.

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