DEPT OF CLINICAL ONCOLOGY



Researcher : Au GKH
List of Research Outputs

Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.


Researcher : Chan HM
List of Research Outputs

Chan H.M., Chen L. and Guan X., CHD1L upregulates TCTP and induce mitotic defects and chromosome missegregation through decreasing Cdk1 activity by Cdc25C ubiquitination, American Association for Cancer Research - Annual Meeting 2011.
Chen L., Chan H.M. and Guan X.Y., Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma., Acta Pharmacologica Sinica. 2010, 31(9): 1165-1171.
Chen L., Yuen Y.F., Li Y., Chan H.M., Zheng B., Huang J. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion., Gut. 2011, 60(4):: 534-43.
Chen L., Chan H.M. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion, American Association for Cancer Research - Annual Meeting 2011.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Li Y., Chan H.M., Chen L. and Guan X., Identification and characterization of SPOCK1 in HCC development, American Association for Cancer Research - Annual Meeting 2011.


Researcher : Chen J
List of Research Outputs

Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Guan X., Fu L., Zhang C., Dong S., Li Y. and Chen J., Wnt2 secreted by tumor fibroblasts promotes tumor growth and cell motility in esophageal carcinoma., 102nd AACR Annual Meeting. 2011.


Researcher : Chen L
Project Title:Clinical Significance of CHD1L and Therapeutic potentials of Virus-mediated CHD1L Depletion in Hepatocellular Carcinoma
Investigator(s):Chen L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:01/2012


Project Title:AACR 102nd Annual Meeting 2011 Clinical Significance of CHD1L in Hepatocellular Carcinoma and Therapeutic potentials of Virus-mediated CHD1L Depletion
Investigator(s):Chen L
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:04/2011
Completion Date:04/2011


List of Research Outputs

Chan H.M., Chen L. and Guan X., CHD1L upregulates TCTP and induce mitotic defects and chromosome missegregation through decreasing Cdk1 activity by Cdc25C ubiquitination, American Association for Cancer Research - Annual Meeting 2011.
Chen L., Chan H.M. and Guan X.Y., Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma., Acta Pharmacologica Sinica. 2010, 31(9): 1165-1171.
Chen L., Yuen Y.F., Li Y., Chan H.M., Zheng B., Huang J. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion., Gut. 2011, 60(4):: 534-43.
Chen L., Chan H.M. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion, American Association for Cancer Research - Annual Meeting 2011.
Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Li Y., Nie C.J., Hu L., Qin Y., Liu H.B., Zeng T.T., Chen L., Fu L., Deng W., Chen S.P., Jia W.H., Zhang C., Xie D. and Guan X.Y., Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers. , Cancer Research. 2010, 70: 5695-5705.
Li Y., Chan H.M., Chen L. and Guan X., Identification and characterization of SPOCK1 in HCC development, American Association for Cancer Research - Annual Meeting 2011.
Wang Z., Wang D., LOO W., Cheng Y., Chen L., Shen J., Yang D., Chow L., Guan X. and Chen J., LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis , Breast cancer research and treatment . Epub, 2011, 2012: 131: 791-800.
Wang Z., Wang D., Loo T.Y., Cheng Y., Chen L., Shen J., yang D., Chow L., Guan X. and Chen J., Spatholobus sub erectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint, 2010.
Xie F., Liu H.B., Zhu Y.H., Qin Y.R., Zeng T.T., Dai Y.D., Chen L., Nie C.J., Tang H., Li Y., Fu L. and Guan X., Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. , BMC Cancer. 2011, 11: 86.


Researcher : Cheng CYH
List of Research Outputs

Kwong D.L.W., Cheng C.Y.H., Wu V.W. and Liu E.S., Evaluation of radiation dose and image quality for the Varian cone beam computed tomography system, International Journal of Radiation Oncology, Biology, Physics. 2011, 80(1): 291-300.


Researcher : Cheng Y
Project Title:Reprogramming of nasopharyngeal carcinoma cells by genetic correction after chromosome transfer
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2010


List of Research Outputs

Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.


Researcher : Cheung AKL
Project Title:Functional investigation of candidate tumor suppressor gene, Protein tyrosine phosphatase receptor type G functional domains and angiogenesis effect.
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2010
Completion Date:06/2011


List of Research Outputs

Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D., Tsao G.S.W. and Lung M.L., Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich intestinal protein 2 in nasopharyngeal carcinoma, The 14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK, 2010.
Cheung A.K.L., New Secondary School Curriculum of Biology and Liberal Studies : Molecular Genetics and Public Health., T.W.G.Hs, Mrs Wu York Yu Memoral College. 2010.
Ko J.M.Y., Cheung A.K.L. and Lung M.L., THSD1: a candidate tumor suppressor attenuates angiogenesis, migratory and invasive potential of endothelial cells, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Clinical Advances in the Study of Esophageal and Gastric Cancers”. The University of Hong Kong, Hong Kong, 2011.
Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.


Researcher : Chua DTT
Project Title:2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/2000


Project Title:2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:11/2001


Project Title:The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:11/2003


Project Title:46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/2004


Project Title:Nasopharyngeal Carcinoma (NPC)
Investigator(s):Chua DTT, Nicholls JM
Department:Clinical Oncology
Source(s) of Funding:Croucher Foundation - Research Grants
Start Date:01/2007


List of Research Outputs

Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010.
Chau J., Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer in Hong Kong (abstract), 7th Annual Conference Organisation for Oncology and Translational Research, 13-14 May 2011, Hong Kong. Hong Kong, Organisation for Oncology and Translational Research, 2011, 46.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.
Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.
Zhang W., Zheng L., Chua D.T.T. and Cheung L.K., Bone regeneration after radiotherapy in an animal model, J Oral Maxillofac Surg. 2010, 68: 2802-9.


Researcher : Dong S
List of Research Outputs

Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199.
Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Guan X., Fu L., Zhang C., Dong S., Li Y. and Chen J., Wnt2 secreted by tumor fibroblasts promotes tumor growth and cell motility in esophageal carcinoma., 102nd AACR Annual Meeting. 2011.
Lee N.P.Y., Tsang F.H., Shek F.H., Mao M., Dai H., Zhang C., Dong S., Guan X.Y., Poon R.T.P. and Luk J.M.C., Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma., International Journal of Cancer. 2010, 127: 968-976.


Researcher : Fu L
Project Title:The role of tumor fibroblasts secreted Wnt2 in esophageal squamous cell carcinoma
Investigator(s):Fu L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009
Completion Date:03/2011


Project Title:9th Asia-Pacific Conference on Human Genetics EPIGENETIC ALTERATION OF ORGANIC CATION TRANSPORTER GENE SLC22A3 CONFERS SUSCEPTIBILITY TO ESOPHAGEAL CANCER IN THE HIGH-RISK NORTHERN CHINESE
Investigator(s):Fu L
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:11/2010
Completion Date:12/2010


Project Title:Characterization of a novel tumor susceptibility gene PSCA in esophageal squamous cell carcinoma
Investigator(s):Fu L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011


List of Research Outputs

Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Guan X., Fu L., Zhang C., Dong S., Li Y. and Chen J., Wnt2 secreted by tumor fibroblasts promotes tumor growth and cell motility in esophageal carcinoma., 102nd AACR Annual Meeting. 2011.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Li Y., Nie C.J., Hu L., Qin Y., Liu H.B., Zeng T.T., Chen L., Fu L., Deng W., Chen S.P., Jia W.H., Zhang C., Xie D. and Guan X.Y., Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers. , Cancer Research. 2010, 70: 5695-5705.
Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562.
Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.
Qin Y.R., Tang H., Xie F., Liu H.B., Zhu Y.H., Li Y., Kwong D.L.W., Fu L. and Guan X., Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma. , Clinical Cancer Research. 2011, 17: 46-55.
Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010.
Xie F., Liu H.B., Zhu Y.H., Qin Y.R., Zeng T.T., Dai Y.D., Chen L., Nie C.J., Tang H., Li Y., Fu L. and Guan X., Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. , BMC Cancer. 2011, 11: 86.


Researcher : Guan X
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/2001


Project Title:Characterization of role and mechanism of eIF-5A2 in tumor metastasis
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2007
Completion Date:09/2010


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:102nd Annual Meeting of American ASSociation for Cancer Research Wnt2 Secreted by Tumor Fibroblasts Promotes Tumor Growth and Cell Motility in Esophageal Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:04/2011
Completion Date:04/2011


List of Research Outputs

Cai M.Y., Tong Z.T., Zheng F., Liao Y.J., Wang Y., Rao H.L., Chen Y.C., Wu Q.L., Liu Y.H., Guan X., Lin M.C., Zeng Y.X., Kung H.F. and Xie D., EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies, Gut. 2011, 60: 967-76.
Cai M.Y., Hou J.H., Rao H.L., Luo R.Z., Li M., Pei X.Q., Lin M.C., Guan X., Kung H.F., Zeng Y.X. and Xie D., High expression of H3K27me3 in human hepatocellular carcinoma correlates closely with vascular invasion and predicts patients worse prognosis, Mol Med . 2010, 17: 12-20.
Chan H.M., Chen L. and Guan X., CHD1L upregulates TCTP and induce mitotic defects and chromosome missegregation through decreasing Cdk1 activity by Cdc25C ubiquitination, American Association for Cancer Research - Annual Meeting 2011.
Chen L., Yuen Y.F., Li Y., Chan H.M., Zheng B., Huang J. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion., Gut. 2011, 60(4):: 534-43.
Chen L., Chan H.M. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion, American Association for Cancer Research - Annual Meeting 2011.
Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199.
Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Guan X., Fu L., Zhang C., Dong S., Li Y. and Chen J., Wnt2 secreted by tumor fibroblasts promotes tumor growth and cell motility in esophageal carcinoma., 102nd AACR Annual Meeting. 2011.
He L.R., Zhao H.Y., Li B.K., Liu Y.H., Liu M.Z., Guan X., Bian X.W., Zeng Y.X. and Xie D., Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients, Int J Cancer. 2010, 129: 143-50.
Li Y., Chan H.M., Chen L. and Guan X., Identification and characterization of SPOCK1 in HCC development, American Association for Cancer Research - Annual Meeting 2011.
Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562.
Ma S.K.Y. and Guan X., MiRegulators in cancer stem cells of solid tumors, Cell Cycle. 2011, 15: 571-2.
Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.
Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.
Qin Y.R., Tang H., Xie F., Liu H.B., Zhu Y.H., Li Y., Kwong D.L.W., Fu L. and Guan X., Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma. , Clinical Cancer Research. 2011, 17: 46-55.
Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010.
Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.
Tong M., Tang K.H., Guan X. and Ma S.K.Y., Loss of Rab25 Expression Promotes Tumor Formation and Angiogenesis in Esophageal Squamous Cell Carcinoma , American Association for Cancer Research - Annual Meeting 2011.
Wang Z., Wang D., LOO W., Cheng Y., Chen L., Shen J., Yang D., Chow L., Guan X. and Chen J., LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis , Breast cancer research and treatment . Epub, 2011, 2012: 131: 791-800.
Wang Z., Wang D., Loo T.Y., Cheng Y., Chen L., Shen J., yang D., Chow L., Guan X. and Chen J., Spatholobus sub erectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint, 2010.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.
Xie F., Liu H.B., Zhu Y.H., Qin Y.R., Zeng T.T., Dai Y.D., Chen L., Nie C.J., Tang H., Li Y., Fu L. and Guan X., Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. , BMC Cancer. 2011, 11: 86.
Yang G., He W., Cai M., Luo F., Kung H., Guan X., Zeng Y. and Xie D., Loss/down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinoma, Int J Gynecol Cancer . 2011, 21: 486-93.


Researcher : Guan X.
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/2001


Project Title:Characterization of role and mechanism of eIF-5A2 in tumor metastasis
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2007
Completion Date:09/2010


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:102nd Annual Meeting of American ASSociation for Cancer Research Wnt2 Secreted by Tumor Fibroblasts Promotes Tumor Growth and Cell Motility in Esophageal Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:04/2011
Completion Date:04/2011


List of Research Outputs

Deng W..., Tsao G...S...W..., Mak W...Y...G..., Tsang C...M..., Ching Y...P..., Guan X..., Huen M...S...Y... and Cheung A..., Impact of G2 checkpoint defect on centromeric instability, Oncogene. 2011, 30: 1281-1289.


Researcher : Guan XY
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:10/2001


Project Title:Characterization of role and mechanism of eIF-5A2 in tumor metastasis
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2007
Completion Date:09/2010


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:102nd Annual Meeting of American ASSociation for Cancer Research Wnt2 Secreted by Tumor Fibroblasts Promotes Tumor Growth and Cell Motility in Esophageal Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:04/2011
Completion Date:04/2011


List of Research Outputs

Chen L., Chan H.M. and Guan X.Y., Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma., Acta Pharmacologica Sinica. 2010, 31(9): 1165-1171.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Li Y., Nie C.J., Hu L., Qin Y., Liu H.B., Zeng T.T., Chen L., Fu L., Deng W., Chen S.P., Jia W.H., Zhang C., Xie D. and Guan X.Y., Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers. , Cancer Research. 2010, 70: 5695-5705.
Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.
Rao Z.Y., Cai M.Y., Yang G.F., He L.R., Mai S.J., Hua W.F., Liao Y.J., Deng H.X., Chen Y.C., Guan X.Y., Zeng Y.X., Kung H.F. and Xie D., EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients., Carcinogenesis. 2010, 31(9): 1576-1583.


Researcher : Hu L
List of Research Outputs

Li Y., Nie C.J., Hu L., Qin Y., Liu H.B., Zeng T.T., Chen L., Fu L., Deng W., Chen S.P., Jia W.H., Zhang C., Xie D. and Guan X.Y., Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers. , Cancer Research. 2010, 70: 5695-5705.


Researcher : Huang Z
List of Research Outputs

Huang Z., Lung H.L. and Lung M.L., Potential Tumor Suppressor Alpha B-Crystallin (CRYAB) Suppresses Tumor Formation and Impairs Cell Invasion and Epithelial-MesenchymalTransition (EMT) In Nasopharyngeal Carcinoma, The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.


Researcher : Ko JMY
Project Title:Mutations in PALB2 in Chinese esophageal cancer families
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:12/2009
Completion Date:05/2011


List of Research Outputs

Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010.
Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM portein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129: 565-573.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D., Tsao G.S.W. and Lung M.L., Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich intestinal protein 2 in nasopharyngeal carcinoma, The 14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK, 2010.
Ko J.M.Y., Cheung A.K.L. and Lung M.L., THSD1: a candidate tumor suppressor attenuates angiogenesis, migratory and invasive potential of endothelial cells, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Clinical Advances in the Study of Esophageal and Gastric Cancers”. The University of Hong Kong, Hong Kong, 2011.
Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Wong V.C., Ko J.M.Y., Qi R.Z., Li P.J., Wang L.D., Li J.L., Chan Y.P., Chan K.W., Stanbridge E.J. and Lung M.L., Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis, British journal of cancer. 2011, 104(5): 841-9.
Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.


Researcher : Kong KL
List of Research Outputs

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.


Researcher : Kong KL
List of Research Outputs

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.


Researcher : Kwan PS
List of Research Outputs

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.


Researcher : Kwong DLW
Project Title:Delineating PET active target in radiotherapy of nasopharyngeal carcinoma
Investigator(s):Kwong DLW, Khong PL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010


List of Research Outputs

Chan K.S., Kwong D.L.W., Yeung D.W.C., Huang B. and Khong P.L., Prognostic impact of standardized uptake value of F-18 FDG PET-CT in nasopharyngeal carcinoma, Clinical Nuclear Medicine (in press). 2011.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D., Tsao G.S.W. and Lung M.L., Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich intestinal protein 2 in nasopharyngeal carcinoma, The 14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK, 2010.
Chung M.F.Y., Law S.Y.K., Kwong D.L.W. and Luk J.M.C., Serum soluble E-cadherin is a potential prognostic marker in esophageal squamous cell carcinoma, Diseases of the Esophagus. 2011, 24(1): 49-55.
Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.
Huang B., Khong P.L., Kwong D.L.W. and Chan K.S., Investigation of Intratumoral Heterogeneity in Nasopharyngeal Carcinoma: A Distinct Role of PET-CT from MRI, 18th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 30-31 October 2010.
Huang B., Kwong D.L.W., Chan K.S. and Khong P.L., Investigation of intratumoral heterogeneity in nasopharyngeal carcinoma using 18F-FDG PET-CT, and comparisons with MRI, World Molecular Imaging Congress 2010, Kyoto, Japan, 7-11 September 2010.
Huang B., Khong P.L., Kwong D.L.W. and Chan K.S., Investigation of ntratumoral heterogeneity in nasopharyngeal carcinoma: a distinct role of PET-CT from MRI, Best Poster Award at 18th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 30-31 October 2010. 2010.
Huang B., Khong P.L., Wong C.S., Kwong D.L.W. and Chan Q., Semi-Quantitative Analysis of Dynamic Contrast-enhanced MRI for characterizing Nasopharyngeal Carcinoma, and Comparison with 18F-FDG PET-CT, ISMRM 19th Annual Meeting & Exhibition, Montreal, Canada, 7-13 May 2011.
Kong K.L., Kwong D.L.W., Fu L., Chan H.M., Chen L., Liu H., Li Y., Zhu Y.H., Bi J., Qin Y.R., Law S.Y.K. and Guan X.Y., Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma, Cancer Reserach. 2010, 70(21): 8832-8841.
Kwong D.L.W., Cheng S.C., Wu V.W. and Ying M.T., Assessment of post-radiotherapy salivary glands, The British Journal of Radiology. 2011, 84(1001): 393-402.
Kwong D.L.W., Cheng C.Y.H., Wu V.W. and Liu E.S., Evaluation of radiation dose and image quality for the Varian cone beam computed tomography system, International Journal of Radiation Oncology, Biology, Physics. 2011, 80(1): 291-300.
Kwong D.L.W., Wu V.W. and Ying M.T., Evaluation of radiation-induced changes to parotid glands following conventional radiotherapy in patients with nasopharygneal carcinoma, The British Journal of Radiology. 2011, 84(1005): 843-9.
Kwong D.L.W., Medical management of Nasopharygneal Carcinoma, Continuous Nursing Education Program. 2011.
Kwong D.L.W., Oncologist management of Nasopharygneal Carcinoma, Continuous Nursing Education Program, 7 July 2010. 2010.
Kwong D.L.W., Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast, Journal of the National Cancer Institute Monographs. 2010, 2010(41): 162-77.
Kwong D.L.W., Cheng S.C., Ying M.T. and Wu V.W., Sonographic appearance of parotid glands in patients treated with intensity-modulated radiotherapy or conventional radiotherapy for nasopharyngeal carcinoma , Ultrasound in Medicine & Biology. 2011, 37(2): 220-30.
Kwong D.L.W., Special lecture: Reflections from the Japan Earthquake – Radiation Exposure: hazards and treatment, 16th Hong Kong Medical Forum, Hong Kong Convention and Exhibition Centre. 2011.
Kwong D.L.W., The day after tomorrow – consequences after nuclear crisis, St. Paul’s Hospital CME/CNE Programme 2011. 2011.
Kwong D.L.W., Treatment for Radiation Exposure, The University of Hong Kong Special Public Seminars – Japan M=9 Earthquake. 2011.
Pow E.H.N., McMillan A.S., Leung K.C.M. and Kwong D.L.W., Oral health-related quality of life following radiotherapy for nasopharyngeal carcinoma, Journal of Dental Research. 2010, 89(Spec Iss B): 2453.
Pow E.H.N., McMillan A.S., Leung K.C.M. and Kwong D.L.W., Oral health-related quality of life following radiotherapy for nasopharyngeal carcinoma, The University of Hong Kong – Sun-Yat-Sen University Conjoint Scientific Meeting. 2010.
Qin Y.R., Tang H., Xie F., Liu H.B., Zhu Y.H., Li Y., Kwong D.L.W., Fu L. and Guan X., Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma. , Clinical Cancer Research. 2011, 17: 46-55.
Tong D.K.H., Law S.Y.K., Kwong D.L.W., Wei W.I., Ng W.M. and Wong K.H., Current management of cervical esophageal cancer, World Journal of Surgery. 2011, 35(3): 600-607.
Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan K.W., Lam A.K.Y. and Wong K.H., Histological regression of squamous esophageal carcinoma assessed by percentage of residual viable cells after neoadjuvant chemoradiation is an important prognostic factor, Ann Surg Oncol. 2010, 17(8): 2184-92.
Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.
Wei W.I. and Kwong D.L.W., Recurrent nasopharyngeal carcinoma: Surgical salvage vs. additional chemoradiation, Current Opinion in Otolaryngology & Head and Neck Surgery. 2011, 19(2): 82-86.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.
Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.


Researcher : Kwong FM
List of Research Outputs

Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.


Researcher : Lai TL
List of Research Outputs

Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.


Researcher : Lee VHF
Project Title:A retrospective analysis of genetic aberrations as predictors of relapse and survival outcomes in completely resected stage III adenocarcinoma of colon after the use of oxaliplatin-based regimen as adjuvant chemotherapy
Investigator(s):Lee VHF, Chua DTT, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2009


Project Title:Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:A prospective study on the anatomical and physiological changes of carotid arteries by doppler ultrasonography after Intensity Modulated Radiation Therapy (IMRT) for untreated nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Wong CS, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


List of Research Outputs

Chau J., Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer in Hong Kong (abstract), 7th Annual Conference Organisation for Oncology and Translational Research, 13-14 May 2011, Hong Kong. Hong Kong, Organisation for Oncology and Translational Research, 2011, 46.
Lee V.H.F., Brain tumour: presentation, investigation and management, Hong Kong Anti-Cancer Society, 2011, Hong Kong Anti-cancer Society. 2011.
Lee V.H.F., Case Sharing, Asia Pacific Lung Conference 2010. 2010.
Lee V.H.F., Management of Hand-foot Syndrome, Hong Kong Society of Clinical Oncology. 2010.
Lee V.H.F., Management of nasopharyngeal carcinoma and its complications, Department of Speech Therapy, Hong Kong East and Hong Kong West Clusters, Hospital Authority. 2011.
Lee V.H.F., Management of nasopharyngeal carcinoma and other head and neck cancers, Institute of Advanced Nursing Studies, Hospital Authority. 2010.
Lee V.H.F., Managment of Oesophageal and Gastric Cancer, Department of Clinical Oncology, Queen Mary Hospital. 2011.
Lee V.H.F., Shifting the paradigm for maintenance therapy for non-small cell lung cancer, Hong Kong College of Radiologists. 2010.
Lee V.H.F., Shifting the paradigm for maintenance therapy for non-small cell lung cancer, Journal of Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2010, 13(Suppl): S16.
Lee V.H.F., Targeted therapy for non-small cell lung cancer, Department of Clinical Oncology, Queen Mary Hospital. 2011.


Researcher : Li VWK
List of Research Outputs

Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.


Researcher : Li Y
List of Research Outputs

Li Y., Chan H.M., Chen L. and Guan X., Identification and characterization of SPOCK1 in HCC development, American Association for Cancer Research - Annual Meeting 2011.


Researcher : Liu KY
List of Research Outputs

Gu J., Khong P.L., Wang S., Chan Q., Wu E.X., Law W.L., Liu K.Y. and Zhang J., Dynamic contrast-enhanced MRI of primary rectal cancer: quantitative correlation with positron emission tomography/computed tomography, Journal of Magnetic Resonance Imaging. 2011, 33(2): 340-347.


Researcher : Lo HYP
List of Research Outputs

Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.


Researcher : Lo PHY
List of Research Outputs

Lo P.H.Y. and Lung M.L., Candidate Tumor Suppressor Gene, CRIP2, Induces Apoptosis In Esophageal Squamous Cell Carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.


Researcher : Lu L
List of Research Outputs

Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.


Researcher : Lung HL
Project Title:The involvement of hypoxic tumor micro-environment in nasopharyngeal carcinoma (NPC) tumorigenesis
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2009
Completion Date:02/2011


Project Title:The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma
Investigator(s):Lung HL, Chua DTT
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2009


Project Title:The functional role of the chromosome X gene, thymosin beta 15, in nasopharyngeal carcinoma
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:02/2011


List of Research Outputs

Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D., Tsao G.S.W. and Lung M.L., Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich intestinal protein 2 in nasopharyngeal carcinoma, The 14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK, 2010.
Huang Z., Lung H.L. and Lung M.L., Potential Tumor Suppressor Alpha B-Crystallin (CRYAB) Suppresses Tumor Formation and Impairs Cell Invasion and Epithelial-MesenchymalTransition (EMT) In Nasopharyngeal Carcinoma, The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.
Lung H.L., Invited lecture-as a guest speaker, Tung Wah Group of Hospitals, Mrs Wu York Yu Memorial College. 2010.
Lung H.L., Reviewer, Journal of Biomedicine and Biotechnology for manuscript . 2010.
Lung H.L. and Lung M.L., The functional role of the chromosome X gene, thymosin beta 15, in nasopharyngeal carcinoma, Small Project Funding, HKU. 2011.
Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.
Yeung M.C., Lung H.L. and Lung M.L., Study of candidate tumor suppressor gene, Serum Amyloid A1 (SAA1), in nasopharyngeal carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.


Researcher : Lung ML
Project Title:Molecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2007
Completion Date:08/2010


Project Title:Molecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2009


Project Title:Centre for Nasopharyngeal Carcinoma Research
Investigator(s):Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:Clinical Oncology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2010


Project Title:14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich instetine protein 2 in nasopharyngeal carcinoma
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:09/2010
Completion Date:09/2010


List of Research Outputs

Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010.
Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM portein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129: 565-573.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.
Cheung A.K.L., Ko J.M.Y., Lung H.L., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D., Tsao G.S.W. and Lung M.L., Functional investigation of tumor and angiogenesis suppressive candidate tumor suppressor, Cysteine-rich intestinal protein 2 in nasopharyngeal carcinoma, The 14th Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK, 2010.
Fu L., Qin Y.R., Tang H., Ai J.Y., Dong S., Lu L., Chen J., Lung M.L., Kwong D.L.W. and Guan X., Epigenetic alteration of organic cation transporter gene SLC22A3 confers susceptibility to esophageal cancer in the high-risk northern Chinese. , The 9th Asia Pacific Conference on Human Genetics.. 2010.
Huang Z., Lung H.L. and Lung M.L., Potential Tumor Suppressor Alpha B-Crystallin (CRYAB) Suppresses Tumor Formation and Impairs Cell Invasion and Epithelial-MesenchymalTransition (EMT) In Nasopharyngeal Carcinoma, The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.
Ko J.M.Y., Cheung A.K.L. and Lung M.L., THSD1: a candidate tumor suppressor attenuates angiogenesis, migratory and invasive potential of endothelial cells, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Clinical Advances in the Study of Esophageal and Gastric Cancers”. The University of Hong Kong, Hong Kong, 2011.
Koon H.K., Lo K.W., Leung K.N., Lung M.L., Chang C.C., Wong R.N., Leung W.N. and Mak N.K., Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein-Barr virus-infected nasopharyngeal carcinoma cells., Cell Mol Immunol.. 2010, 7: 323-6.
Koon H.K., Chan P.S., Wu A.G., Wong R.N., Lung M.L., Chang C.K. and Mak N.K., Role of mitogen-activated protein kinase in Zn-BC-AM PDT-induced apoptosis in nasopharyngeal carcinoma cells., Cell Biochem Funct.. 2010, 28: 239-248.
Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.
Lo P.H.Y. and Lung M.L., Candidate Tumor Suppressor Gene, CRIP2, Induces Apoptosis In Esophageal Squamous Cell Carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.
Lung H.L., Cheung A.K.L., Cheng Y., Kwong F.M., Lo P.H.Y., Law E.W., Chua D.T.T., Zabarovsky E.R., Wang N., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma, International journal of cancer. . 2010, 127(2): 304-12.
Lung H.L. and Lung M.L., The functional role of the chromosome X gene, thymosin beta 15, in nasopharyngeal carcinoma, Small Project Funding, HKU. 2011.
Lung M.L., Genetics of nasopharyngeal carcinoma: approaches and current status, 5th International Symposium on Nasopharyngeal Carcinoma. Penang, Malaysia, 2011.
Lung M.L., Identification and functional analysis of tumor suppressor genes in nasopharyngeal carcinoma, National Health Research Institute and HKU Scientific meeting. Taipei, Taiwan, 2011.
Lung M.L., Identification and functional analysis of tumor suppressor genes in nasopharyngeal carcinoma, National University of Taiwan. Taipei, Taiwan, 2011.
Wong V.C., Ko J.M.Y., Qi R.Z., Li P.J., Wang L.D., Li J.L., Chan Y.P., Chan K.W., Stanbridge E.J. and Lung M.L., Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis, British journal of cancer. 2011, 104(5): 841-9.
Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.
Yeung M.C., Lung H.L. and Lung M.L., Study of candidate tumor suppressor gene, Serum Amyloid A1 (SAA1), in nasopharyngeal carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.
Yip Y.L., Tsang C.M., Deng W., Cheung P.P.Y., Jin Y., Cheung A., Lung M.L. and Tsao G.S.W., Expression of Epstein-Barr Virus-encoded LMP1 and hTERT extends the life span and immortalizes primary cultures of nasopharyngeal epithelial cells. , Journal of Medical Virology. 2010, 10: 1711-23.
Yu Z., Wong C.L. and Lung M.L., Role of DNAJB6 in epithelial-mesenchymal transition in esophageal squamous cell carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.
Yu Z., Wong V. and Lung M.L., The role of DNAJB6 in esophageal squamous cell carcinoma metastasis, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Clinical Advances in the Study of Esophageal and Gastric Cancers”. Hong Kong, 2011.
Zabarovsky E.R., Senchenko V., Loginov V., Pavlova T., Zabarovska V., Dmitriev A., Lung M.L., Panda C.K., Kashuba V., Lerman M.I. and Braga E.A., Positional cloning of tumor suppressor genes from 3p21.3 involved in major human cancers, Horizons in Cancer Research . NY, Nova Science Publishers, 2010, 42: 103-127.


Researcher : Sham JST
List of Research Outputs

Wong W., Lam C.L.K., Sham J.S.T. and Fong D.Y.T., Effectiveness of Traditional Chinese Medicine in Primary Care, Chinese Medicine. InTech, 2011.


Researcher : Tsang JWH
Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang JWH, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang JWH, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


List of Research Outputs

Au A.H.Y., Lam W.W.T., Kwong A., Suen D.T.K., Tsang J.W.H., Yeo W., Suen J., Ho W.M., Yau T.K., Soong I., Wong K.Y., Sze W.K., Ng A., Girgis A. and Fielding R., Prevalence of psychosocial unmet needs of Chinese women facing advanced breast cancer (abstract and poster presentation), The 2nd Meeting of East Asia Psycho-Oncology Society, 23-24 August 2010, Hong Kong. Hong Kong, School of Public Health, University of Hong Kong, 2010, 31.
Au H.Y.A., Lam W.W.T., Kwong A., Suen D.T.K., Tsang J.W.H., Yeo W., Suen J., Ho W.M., Yau T.K., Soong I., Wong K.Y., Sze W.K., Ng A., Girgis A. and Fielding R., Validation of the supportive care needs survey (SCNS-SF34): the Chinese version (Ch-SCNS-SF34) (abstract), 17th Hong Kong International Cancer Congress, 3-5 November 2010, Hong Kong. Hong Kong, University of Hong Kong, 2010.
Chu J.P., Mak H.K.F., Yau K.K.W., Zhang L., Tsang J.W.H., Chan Q. and Leung G.K.K., A Pilot Study On Correlation Of Mr Perfusion (ktrans) And Diffusion (apparent Diffusion Coefficient) Parameters In Brain Tumors , Radiological Society of North America. 2010.
Tsang J.W.H., Antiangiogenesis in Glioblastoma Multiforme (GBM) - Progress & Promise, 2010 Annual Scientific Meeting, organized by the Hong Kong College of Radiologists. 2010.
Tsang J.W.H., Biology and Fundamentals of Triple Negative Breast Cancer, 2010 Asia Pacific Oncology Conference, Hong Kong. 2010.
Tsang J.W.H., Emerging Therapeutics In Colorector Cancer - New Horizons And New Challenges, 2010 Annual Scientific Meeting, organized by the Hong Kong College of Physians. 2010.
Tsang J.W.H., HER-2 positive breast cancer and its predisposition to brain metastasis, Health Column, Oriental Daily. 2010.
Tsang J.W.H., Her-2 Metastatic Breast Cancer Case Sharing, Metastatic Breast Cancer Case Sharing Meeting for Breast Oncologists. 2010.
Tsang J.W.H., How To Further Improve Neoadjuvant Treatment Of Her-2 Positive Breast Cancer, Hong Kong College of Radiologists. 2011.
Tsang J.W.H., Management Of Common Breast Cancer Treatment-related Side Effects -invited By The Hong Kong Breast Cancer Foundation, Hong Kong Breast Cancer Foundation. 2010.
Tsang J.W.H., New Horizons In The Management Of Glioblastoma Multiforme - The End Of The Beginning?, Hong Kong First Oncology Forum Organized by the Hong Kong Society of Clinical Oncology. 2010.
Tsang J.W.H., Patient-centred Personalised Treatment For Her-2 Positive Metastatic Breast Cancer Case Sharing, Asia Oncology Summit 2011, Hong Kong. 2011.
Tsang J.W.H., Personalised Management For Breast Cancer - "one-size-fits-all" Approach Is Over, But What Next?, The Hong Kong Medical Diary. 2011, 16: 23-26.
Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.
Tsang J.W.H., The Cutting Edge In Breast Cancer Treatment: From Hormone, Chemotherapy To Targeted Therapy - Invited Lecture From The Hong Kong Polytechnic University, 2010.
Tsang J.W.H., The Era Of Targeted Therapy And Beyond - Matching Science With The Affordability, The Multi-Specialty Medical MEGA Conference. 2011.
Tsang J.W.H., The Physicians' Perspectives On Discussing Self-financed Cancer Treatment With Cancer Patients, 17th Hong Kong International Cancer Congress. 2010.
Tsang J.W.H., Understanding Geriatric Oncology - invited lecture by the Hong Kong Nurses General Union, 2010.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.


Researcher : Wong AMG
List of Research Outputs

Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562.
Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.


Researcher : Wong AMG
List of Research Outputs

Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562.
Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010.
Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2011, Epub ahead of print.


Researcher : Wong CL
List of Research Outputs

Yu Z., Wong C.L. and Lung M.L., Role of DNAJB6 in epithelial-mesenchymal transition in esophageal squamous cell carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.


Researcher : Yeung MC
List of Research Outputs

Yeung M.C., Lung H.L. and Lung M.L., Study of candidate tumor suppressor gene, Serum Amyloid A1 (SAA1), in nasopharyngeal carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.


Researcher : Yu Z
List of Research Outputs

Yu Z., Wong C.L. and Lung M.L., Role of DNAJB6 in epithelial-mesenchymal transition in esophageal squamous cell carcinoma, The 15th Research Postgraduate Symposium. Hong Kong SAR, China, 2010.
Yu Z., Wong V. and Lung M.L., The role of DNAJB6 in esophageal squamous cell carcinoma metastasis, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Clinical Advances in the Study of Esophageal and Gastric Cancers”. Hong Kong, 2011.


Researcher : Yung ST
List of Research Outputs

Tsang J.W.H., Yung S.T., Li V.W.K., Lai T.L., Au G.K.H. and Kwong D.L.W., Revealing the attitudes towards community belief, empowering oncologists and cancer carers: using breast cancer as an illustration, East Asia Psycho-Oncology 2 Meeting 2010.


Researcher : Zhang L
List of Research Outputs

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/{beta}-catenin signalling pathway. , Gut. 2011.


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