DEPT OF BIOCHEMISTRY
| Researcher : Agrawal KR |
| List of Research Outputs |
| Yang S., Agrawal K.R., Lam T.W., Sham P.C., Cheah K.S.E. and Wang J.J., A novel Profile Hidden Markov Model to predict microRNAs and their targets simultaneously. , 9th Annual International Conference on Computational Systems Bioinformatics, Stanford, United States. August 16-18. 2010. |
| Researcher : Au YK |
| List of Research Outputs |
| Cheah K.S.E., Guo S., Wynn S., Au Y.K., Aszodi A., Fassler R. and Chan D., Lack of 1 integrin in the developing mouse notochord results in hemivertebrae. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011.. 2011. |
| Cheah K.S.E., Au Y.K., Wynn S.A.R.A.H., Chan Y.S., Cheung K.M.C., Chan W...Y..., Lovell-Badge R.H., Chan D. and Fritzsch B..., Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation., The Fourth Annual Introductory Course on Skeletal Dysplasias, an international course for phycisians and scientists, Freiburg, Germany, 8 July, 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Guo S., Wynn S...L..., Au Y.K., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of beta1 integrin results in hemivertebrae development in mice, Functional Genomics Next Generation Applicaitons & Technologies, February 3-4, 2011, DECHEMA-Haus. Frankfurt am Main. Germany. 2011. |
| Researcher : Bao S |
| List of Research Outputs |
| Bao S., Jiang R. and Song Y., Evaluation of Next Generation Sequencing software in mapping and assembly, PRAGMA19. 2010. |
| Bao S., Jiang R., Kwan W.K., Wang B., Ma X. and Song Y., Evaluation of next-generation sequencing software in mapping and assembly, J Hum Genet. 2011, 56: 406-414. |
| Bao S. and Song Y., Identification of "Stemness" Genes by Integrating Differentially Expressed Genes from Multiple Stem Cell Microarray Databsets, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2011. HK, 2010. |
| Researcher : Boyde TRC |
| List of Research Outputs |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2010. |
| Researcher : Cai K |
| List of Research Outputs |
| Sham M.H. and Cai K., Angiogenesis and lung cancer: Antiangiogenic agent and therapy, In: Chatterjee M., Rana, A., Rana, B., Angiogenesis and Therapeutic Target of Cancer. Bentham Sci. Publ., 2010, 1. |
| Researcher : Cham WC |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th Int’l Symp. on Healthy Aging: 68. 2011. |
| Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 68. [HK. March 5-6, 2011]. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th Int’l Symp. on Healthy Aging: 57. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Researcher : Chan CCY |
| List of Research Outputs |
| Chan C.C.Y., Chan W.L., Tanner J.A., Chan D. and Cheah K.S.E., A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011. . 2011. |
| Researcher : Chan CH |
| List of Research Outputs |
| Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Chan C.H., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Use of sulfated maltoheptaose to lower neutrophilic inflammation in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Implication in the Role of Serglycin in Neutrophils: Retention of Neutrophil Elastase in Granules and Inhibition of Neutrophil Elastase Activity during Storage , American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Binds Serglycin During Storage in Granules and Changes its Binding Partner to Shed Syndecan-1 after Degranulation , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Changes its Binding Partner following Neutrophil Degranulation in Airway Inflammation , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Li C.H., Chik T.K., Ngan A.H.W., Chan C.H., Shum D.K.Y. and Chan B.P., Correlation between compositional and mechanical properties of human mesenchymal stem cell-collagen microspheres during chondrogenic differentiation., Tissue Engineering Part A . 2011, 17(5-6): 777-788. |
| Researcher : Chan CP |
| List of Research Outputs |
| Chan C.P., Kok K.H. and Jin D., CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models, Cell & Bioscience. 2011, 1: 6. |
| Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010. |
| Jin D., Chan C.P. and Siu Y.T., Group I p21-activated kinases are required for optimal activation of human T cell leukemia virus type 1 long terminal repeats by viral oncoprotein Tax, The American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, Montana, USA, July 17-21, 2010.. 2010. |
| Mak T.Y., Chan C.P. and Jin D., Comparative Analysis of bZIP Transcription Factors of the CREB3 Subfamily , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Chan CP |
| List of Research Outputs |
| Chan C.P., Kok K.H. and Jin D., CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models, Cell & Bioscience. 2011, 1: 6. |
| Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010. |
| Jin D., Chan C.P. and Siu Y.T., Group I p21-activated kinases are required for optimal activation of human T cell leukemia virus type 1 long terminal repeats by viral oncoprotein Tax, The American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, Montana, USA, July 17-21, 2010.. 2010. |
| Mak T.Y., Chan C.P. and Jin D., Comparative Analysis of bZIP Transcription Factors of the CREB3 Subfamily , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Chan CYT |
| List of Research Outputs |
| Chan C.Y.T. and Wong N.S., Evidence for Physical Interaction between CHOP/Gadd153 mRNA and Specific Intracellular Proteins , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Role of Indian hedgehog signaling in phalangeal joint formation and Brachydactylies |
| Investigator(s): | Chan D, Cheah KSE, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| List of Research Outputs |
| Chan C.C.Y., Chan W.L., Tanner J.A., Chan D. and Cheah K.S.E., A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011. . 2011. |
| Chan C.W., Lam S.K.L., Leung Y.L., Chan D., Luk K.D.K. and Cheung K.M.C., Minimizing Cryoperservation-Induced Loss of Disc Cell Activity for Storage of Whole Intervertebral Disc, Eur Cells and Materials. 2010, 19: 273-283. |
| Chan D., A basic review of genetics, Combined Scientific Meeting (CSM 2011), 14-17 May 2011, Hong Kong Convention and Exhibition Centre, Hong Kong. 2011. |
| Chan D., Bone and Development, JAMA. 2010, 304: 1498-1499. |
| Chan D., Genetics in the understanding of disc degeneration, World Forum for Spine Research 2010 - The Intervertebral Disc, Montreal, Canada, 5-8 July 2010. 2010. |
| Chan W.C.W., Zhang L., Chan T., Ikegawa S., Cheung K.M.C., Cheah K.S.E. and Chan D., ER-stress induces early onset intervertebral disc degeneration in a mouse model for metaphyseal chondrodysplasia type Schmid, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Chan W.C.W., Zhang L., Chan W.Y., Cheung K.M.C., Cheah K.S.E. and Chan D., Early onset intervertebral disc degeneration in a mouse model of Metaphysealchondrodysplasia type Schmid. , World Forum for Spine Research 2010—The Intervertebral Disc, Montreal, Canada, July 5 – 8, 2010. . 2010. |
| Chan W.L., Lau E., Chan D., Chu I., Cheah K.S.E. and Tanner J.A., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes. , Human Proteome Organization Meeting HUPO2010, Sydney, Australia, September 24, 2010.. 2010. |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Cheah K.S.E., Guo S., Wynn S., Au Y.K., Aszodi A., Fassler R. and Chan D., Lack of 1 integrin in the developing mouse notochord results in hemivertebrae. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011.. 2011. |
| Cheah K.S.E., Au Y.K., Wynn S.A.R.A.H., Chan Y.S., Cheung K.M.C., Chan W...Y..., Lovell-Badge R.H., Chan D. and Fritzsch B..., Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation., The Fourth Annual Introductory Course on Skeletal Dysplasias, an international course for phycisians and scientists, Freiburg, Germany, 8 July, 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Cheng H.W., Chan D., Cheung K.M.C. and Chan B.P., Generation of an osteochondral interface using rabbit mesenchymal stem cells (rMSCs) and collagen gel. , World Forum for Spine Research, 5-8 Jul, 2010, Montreal, Canada.. 2010, 1068. |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Gemome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in Southern China, 12th International Phillip Zorab Symposium, London, UK, March 16-18, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in southern China, 12th International Phillip Zorab Symposium, 2011 . 2011. |
| Feng C., Chan D., Hu J., Stricker S.I.G.M.A.R. and Mundlos S.T.E.F.A.N., Role of IHH Signaling in the Progression of Joint Formation in Digit Development , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2011. HK, 2010. |
| Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Necessary for Chondrocyte Cytokinesis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K.F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range, Research Output Prize, The University of Hong Kong. 2010. |
| Guo S., Wynn S...L..., Au Y.K., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of beta1 integrin results in hemivertebrae development in mice, Functional Genomics Next Generation Applicaitons & Technologies, February 3-4, 2011, DECHEMA-Haus. Frankfurt am Main. Germany. 2011. |
| Klopocki E., Lohan S., Brancati F., Koll R., Brehm A., Seemann P., Dathe K., Stricker S., Hecht J., Bosse K., Betz R.C., Garaci F.G., Dallapiccola B., Jain M., Muenke M., Ng V.C.W., Chan W.C.W., Chan D. and Mundlos S., Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis., Am J Hum Genet. 2011, 88(1): 70-5. |
| Kolanczyk M., Pech M., Zemojtel T., Yamamoto H., Mikula I., Calvaruso M.A., van den B.M., Richter R., Fischer B., Ritz A., Kossler N., Thurisch B., Spoerle R., Smeitink J., Kornak U., Chan D., Vingron M., Martasek V., Lightowlers R.N., Nijtmans L., Schuelke M., Nierhaus K.H. and Mundlos S., NOA1 is an essential GTPase required for mitochondrial protein synthesis, Mol. Biol. Cell. 2011, 22: 1-22. |
| Lam T.K., Au T.Y., Leung Y.L., Wynn S., Chan D., Cheah K.S.E. and Cheung K.M.C., Presence of notochord descendent cells in the nucleus pulposus of adult mice showing signs of intervertebral disc degeneration, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for Osteoarthritis and Degenerative Disc Disease. , 2010 World Forum of Spine Research, Montreal, Canada, July 5-8, 2010.. 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011. . 2011. |
| Leung W.L., Wong S.Y., Chan D., Tam P.P.L. and Cheah K.S.E., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain, Developmental Dynamics. 2010, 239: 2319-2329. |
| Leung Y.L., Lim F., Hung S., Tuan R., Chan D. and Cheung K.M.C., Defining the phenotype and molecular signatures of notochordal nucleus pulposus cells, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Leung Y.L., Tsui Y.K., Kao R.Y.T., Sun Y., Masuda K., Chan D. and Cheung K.M.C., Modulating proteoglycan metabolisum using small molecules as treatment for disc degeneratioin, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Leung Y.L., Hung S., Lau R., Tam V., Yang F., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Structural and functional evaluation of allogeneic MSC-based disc regeneration: implications of dosage and stage of degeneration with long-term follow-up, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Lim F.L., Cheung K.M.C., Chan D. and Leung Y.L., Spatiotemporal expression of cadherin 2 in the notochordal nucleus pulposus during development and aging of murine intervertebral disc, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Ma G., Yu J., Chan D., Gao B., Hu J., He Y., Guo S., Zhou J., Zhang L., Kang Y., Cheah K.S.E., Feng G., Guo X., Wang Y., Zhou C.Z. and He L., Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels, Cell Res (in press doi:10.1038/cr.2011.76) . 2011. |
| Pei S.L.C., Chan W.C.W., Tsang K.Y., Mills A.A., Cheung M.C.H. and Chan D., Role of p53/p63 in Chondrocyte Re-differentiation upon Activation of ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Samartzis D., Karppinen J., Chan D., Luk K.D.K. and Cheung K.M.C., The association of disc degeneration based on magnetic resonance imaging and the presence of low back pain, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Samartzis D., Karppinen J., Chan D., Luk K.D.K. and Cheung K.M.C., The association of disc degeneration based on magnetic resonance imaging and the presence of low back pain, World Forum for Spine Research: Intervertebral Disc. Montreal, Canada, 2010. |
| Shen Y., Ng V.C.W., Cheung S.K.C., Shen W., Lam Y.W., Agata K., Chan B.P. and Chan D., The Study of Extracellular Matrix and Stem Cell Niche in Planarian, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Generation of a mouse model to study ADAMTS-5 as a genetic risk factor for intervertebral disc degeneration, Basic science GSC2011-ABS-1530,Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011.. 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011. . 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D., Cheah K.S.E., Cheung K.M.C. and Chan D., Impact of activating ADAMTS-5 in cartilage-related degenerative disorders, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Sze K.L., Nagy A., Fosang A., McCulloch D., Cheah K.S.E., Cheung K.M.C. and Chan D., Poster presentation: Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders , World Forum for Spine Research, Montreal, Canada, 05 Jul 2010 - 08 Jul 2010. |
| Tam V., Cheung K.M.C. and Chan D., AOSpine East Asia Research Grant Award, AOSpine East Asia Council. 2011. |
| Tam V., Rogers I., Chan D. and Cheung K.M.C., Investigation of the homing ability of mesenchymal-like stem cells to sites of injury using a mouse model of IVD degeneration, 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Witte F., Chan D., Economides A.N., Mundlos S. and Stricker S., Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region, PNAS. 2010, 107: 14211-14216. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol Biosynthesis is a Potential Pathway Involved in the Degeneration of the Annulus Fibrosus, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol biosynthesis is a potential pathway involved in the degeneration of the annulus fibrosus, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Yee F.Y.A., Melhado I.G., Cheah K.S.E., Cheung K.M.C. and Chan D., Transcriptome of the Human Intervertebral Disc in Health and Disease, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Yu Y., Chan D. and Tanner J.A., Nucleic acid aptamers against ADAMTS as a new therapeutic approach against degenerative disc disease, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Zwolanek D., Velt G., Eble J...A..., Chan D., Stetefeld J... and Koch M., Collagen XXII interacts with integrins via new motifs and links tenocytes to myocytes, XXIInd Meeting on the Federation of European Connective Tissue Societies, Davos, Switzerland, July 3-7, 2010. |
| Researcher : Chan D. |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Role of Indian hedgehog signaling in phalangeal joint formation and Brachydactylies |
| Investigator(s): | Chan D, Cheah KSE, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| List of Research Outputs |
| Chan W...L..., Lau E., Chan D..., Chu I...K..., Cheah K...S...E... and Tanner J...A..., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes, Human Proteome Organization Meeting HUPO2010, Sydney. Australia, 2010. |
| Researcher : Chan JKM |
| List of Research Outputs |
| Sugiyama N., Varjosalo M., Meller P., Lohi J., Chan J.K.M., Zhou Z., Alitalo K., Taipale J., Keski-Oja J. and Lehti K., FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex., Proc Natl Acad Sci U S A. . 2010. |
| Researcher : Chan KMJ |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Chan L |
| List of Research Outputs |
| Zhang G.L., Chen X.C., Chan L., Zhang M.X., Zhu B.H., Wang L.T., Zhu Z.Y., Zhang J., Zhou B.P. and Wang J.J., An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese, Sci. Rep.. 2011, 1: 20. |
| Researcher : Chan SCL |
| List of Research Outputs |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Differential regulation of retinoic acid signaling in adult spinal cord neural progenitors., 9th Annual International Society of Stem Cell Research Meeting, Toronto, Canada, June 15-18, 2011. |
| Researcher : Chan SLC |
| List of Research Outputs |
| Shum K...T..., Chan S.L.C., Leung C...M... and Tanner J...A..., Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signaling, Biochemical Journal. 2011, 434: 501-510. |
| Shum K.T., Chan S.L.C. and Tanner J.A., Inhibiting sclerostin with a nucleic acid aptamer as a new approach to osteoporosis therapy, Johnson & Johnson Outstanding Graduate Thesis Award in Biotech One Day Symposium. 2011. |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, PCT Patent Application No. PCT/CN2011/000879 filed on 23 May 2011. 2011. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, U.S. Non-Provisional Application No. 13/116,244 filed on 26 May 2011. 2011. |
| Researcher : Chan W.L. |
| List of Research Outputs |
| Chan W...L..., Lau E., Chan D..., Chu I...K..., Cheah K...S...E... and Tanner J...A..., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes, Human Proteome Organization Meeting HUPO2010, Sydney. Australia, 2010. |
| Researcher : Chan WCW |
| List of Research Outputs |
| Chan W.C.W., Zhang L., Chan T., Ikegawa S., Cheung K.M.C., Cheah K.S.E. and Chan D., ER-stress induces early onset intervertebral disc degeneration in a mouse model for metaphyseal chondrodysplasia type Schmid, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Chan W.C.W., Zhang L., Chan W.Y., Cheung K.M.C., Cheah K.S.E. and Chan D., Early onset intervertebral disc degeneration in a mouse model of Metaphysealchondrodysplasia type Schmid. , World Forum for Spine Research 2010—The Intervertebral Disc, Montreal, Canada, July 5 – 8, 2010. . 2010. |
| Klopocki E., Lohan S., Brancati F., Koll R., Brehm A., Seemann P., Dathe K., Stricker S., Hecht J., Bosse K., Betz R.C., Garaci F.G., Dallapiccola B., Jain M., Muenke M., Ng V.C.W., Chan W.C.W., Chan D. and Mundlos S., Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis., Am J Hum Genet. 2011, 88(1): 70-5. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Pei S.L.C., Chan W.C.W., Tsang K.Y., Mills A.A., Cheung M.C.H. and Chan D., Role of p53/p63 in Chondrocyte Re-differentiation upon Activation of ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Researcher : Chan WL |
| List of Research Outputs |
| Chan C.C.Y., Chan W.L., Tanner J.A., Chan D. and Cheah K.S.E., A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011. . 2011. |
| Chan W.L., Lau E., Chan D., Chu I., Cheah K.S.E. and Tanner J.A., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes. , Human Proteome Organization Meeting HUPO2010, Sydney, Australia, September 24, 2010.. 2010. |
| Researcher : Chan WY |
| List of Research Outputs |
| Chan W.C.W., Zhang L., Chan W.Y., Cheung K.M.C., Cheah K.S.E. and Chan D., Early onset intervertebral disc degeneration in a mouse model of Metaphysealchondrodysplasia type Schmid. , World Forum for Spine Research 2010—The Intervertebral Disc, Montreal, Canada, July 5 – 8, 2010. . 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Researcher : Chan YTC |
| List of Research Outputs |
| Chan Y.T.C. and Wong N.S., Evidence for direct and specific physical interaction between the stress-inducible CHOP mRNA and intracellular proteins, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2011. |
| Researcher : Chang CN |
| List of Research Outputs |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Researcher : Cheah K.S.E. |
| Project Title: | The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Arthritis and Rheumatism Council (ARC) - General Award |
| Start Date: | 12/1993 |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 09/2008 |
| Completion Date: | 08/2011 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Genetic analyses of sensory fate determination in inner ear development |
| Investigator(s): | Cheah KSE, Lok S |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | 23rd Annual Meeting on Mouse Development, Genetics & Genomics Integration of pathways mediating chondrocyte adaptation to ER stress in vivo |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Chan W...L..., Lau E., Chan D..., Chu I...K..., Cheah K...S...E... and Tanner J...A..., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes, Human Proteome Organization Meeting HUPO2010, Sydney. Australia, 2010. |
| Researcher : Cheah KSE |
| Project Title: | The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Arthritis and Rheumatism Council (ARC) - General Award |
| Start Date: | 12/1993 |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 09/2008 |
| Completion Date: | 08/2011 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Genetic analyses of sensory fate determination in inner ear development |
| Investigator(s): | Cheah KSE, Lok S |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | 23rd Annual Meeting on Mouse Development, Genetics & Genomics Integration of pathways mediating chondrocyte adaptation to ER stress in vivo |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Chan C.C.Y., Chan W.L., Tanner J.A., Chan D. and Cheah K.S.E., A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011. . 2011. |
| Chan W.C.W., Zhang L., Chan T., Ikegawa S., Cheung K.M.C., Cheah K.S.E. and Chan D., ER-stress induces early onset intervertebral disc degeneration in a mouse model for metaphyseal chondrodysplasia type Schmid, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Chan W.C.W., Zhang L., Chan W.Y., Cheung K.M.C., Cheah K.S.E. and Chan D., Early onset intervertebral disc degeneration in a mouse model of Metaphysealchondrodysplasia type Schmid. , World Forum for Spine Research 2010—The Intervertebral Disc, Montreal, Canada, July 5 – 8, 2010. . 2010. |
| Chan W.L., Lau E., Chan D., Chu I., Cheah K.S.E. and Tanner J.A., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes. , Human Proteome Organization Meeting HUPO2010, Sydney, Australia, September 24, 2010.. 2010. |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Cheah K.S.E., Guo S., Wynn S., Au Y.K., Aszodi A., Fassler R. and Chan D., Lack of 1 integrin in the developing mouse notochord results in hemivertebrae. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011.. 2011. |
| Cheah K.S.E., Au Y.K., Wynn S.A.R.A.H., Chan Y.S., Cheung K.M.C., Chan W...Y..., Lovell-Badge R.H., Chan D. and Fritzsch B..., Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation., The Fourth Annual Introductory Course on Skeletal Dysplasias, an international course for phycisians and scientists, Freiburg, Germany, 8 July, 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Gemome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in Southern China, 12th International Phillip Zorab Symposium, London, UK, March 16-18, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in southern China, 12th International Phillip Zorab Symposium, 2011 . 2011. |
| Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Necessary for Chondrocyte Cytokinesis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K.F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range, Research Output Prize, The University of Hong Kong. 2010. |
| Guo S., Wynn S...L..., Au Y.K., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of beta1 integrin results in hemivertebrae development in mice, Functional Genomics Next Generation Applicaitons & Technologies, February 3-4, 2011, DECHEMA-Haus. Frankfurt am Main. Germany. 2011. |
| Ho B.S., Cheng C.C.W., Leung K.K.H., Cheah K.S.E. and Koopman P., The Role of Sox2 and Sox18 in Mouse Hair Cycle and Specification , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Lam T.K., Au T.Y., Leung Y.L., Wynn S., Chan D., Cheah K.S.E. and Cheung K.M.C., Presence of notochord descendent cells in the nucleus pulposus of adult mice showing signs of intervertebral disc degeneration, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for Osteoarthritis and Degenerative Disc Disease. , 2010 World Forum of Spine Research, Montreal, Canada, July 5-8, 2010.. 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011. . 2011. |
| Leung W.L., Wong S.Y., Chan D., Tam P.P.L. and Cheah K.S.E., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain, Developmental Dynamics. 2010, 239: 2319-2329. |
| Li J. and Cheah K.S.E., Tissue-specific Transcriptional Regulation of Sox2 Expression in Mouse Inner Ear Development, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Ma G., Yu J., Chan D., Gao B., Hu J., He Y., Guo S., Zhou J., Zhang L., Kang Y., Cheah K.S.E., Feng G., Guo X., Wang Y., Zhou C.Z. and He L., Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels, Cell Res (in press doi:10.1038/cr.2011.76) . 2011. |
| Scott C.E., Wynn S.L., Sesay A., Cruz C., Cheung M.C.H., Gaviro M.-.V. .G., Booth S., Gao B., Cheah K.S.E., Lovell-Badge R. and Briscoe J., Sox9 induces and maintains neural stem cells, Nature Neuroscience. 2010, 13: 1181-1189. |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Generation of a mouse model to study ADAMTS-5 as a genetic risk factor for intervertebral disc degeneration, Basic science GSC2011-ABS-1530,Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011.. 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011. . 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D., Cheah K.S.E., Cheung K.M.C. and Chan D., Impact of activating ADAMTS-5 in cartilage-related degenerative disorders, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Sze K.L., Nagy A., Fosang A., McCulloch D., Cheah K.S.E., Cheung K.M.C. and Chan D., Poster presentation: Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders , World Forum for Spine Research, Montreal, Canada, 05 Jul 2010 - 08 Jul 2010. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Yang S., Agrawal K.R., Lam T.W., Sham P.C., Cheah K.S.E. and Wang J.J., A novel Profile Hidden Markov Model to predict microRNAs and their targets simultaneously. , 9th Annual International Conference on Computational Systems Bioinformatics, Stanford, United States. August 16-18. 2010. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol Biosynthesis is a Potential Pathway Involved in the Degeneration of the Annulus Fibrosus, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol biosynthesis is a potential pathway involved in the degeneration of the annulus fibrosus, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Yee F.Y.A., Melhado I.G., Cheah K.S.E., Cheung K.M.C. and Chan D., Transcriptome of the Human Intervertebral Disc in Health and Disease, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Researcher : Chen L |
| List of Research Outputs |
| Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Researcher : Cheng CCW |
| List of Research Outputs |
| Choy S.W., Cheng C.C.W., Lee S.T., Li V.W.T., Hui M.N.Y., Hui C.C. and Cheng S.H., A cascade of irx1a and irx2a controls shh expression during retinogenesis, Developmetal Dynamics. 2010, 239: 3204-3214. |
| Ho B.S., Cheng C.C.W., Leung K.K.H., Cheah K.S.E. and Koopman P., The Role of Sox2 and Sox18 in Mouse Hair Cycle and Specification , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Researcher : Cheng LYL |
| Project Title: | A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community |
| Investigator(s): | Cheng LYL, Tan-Un KC |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| List of Research Outputs |
| Zhang W., Tian Z., Sha S., Cheng L.Y.L., Philipsen S. and Tan-Un K.C., Biochim Biophys Acta. , In: Zhang W, Tian Z, Sha S, Cheng LY, Philipsen S, Tan-Un KC., Functional and sequence analysis of human neuroglobin gene promoter region.. 2011, 1809(4-6): 236-244. |
| Zhang W., Cheng L.Y.L. and Tan-Un K.C., DNA methylation status influences expression of human neuroglobin gene, In: Wei Zhang, L.Y.L.Cheng, K.C.Tan-Un, Epigenetics and developmental programming conference (Newcastle, UK). 2011. |
| Researcher : Cheng MH |
| List of Research Outputs |
| Tam C.N., Cheng M.H., Tsang S.L., Sham M.H., Yam G.H.F. and Pang C.P., A Mutant gA-crystallin Leads to Cataractogenesis through the Unfolded Protein Response, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Researcher : Cheung MCH |
| Project Title: | In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development |
| Investigator(s): | Cheung MCH, Zhou G |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | 2011 Gordon Research Conference on Cartilage Biology and Pathology Generation of induced pluripotent stem (iPS) cells from bone forming cells |
| Investigator(s): | Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 03/2011 |
| Completion Date: | 03/2011 |
| List of Research Outputs |
| Cheung M.C.H., Developing Strategies to generate osteochondroprogenitors for skeletal regeneration, Stem Cell & Regenerative Medicine Consortium HKU. 2011. |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K.F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range, Research Output Prize, The University of Hong Kong. 2010. |
| Kwok C.S.T., Wu M.H., Cheung M.C.H., Herve A. and Nieto M.A., The Role of SoxE Transcription Factors in Melanoma Development , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Pei S.L.C., Chan W.C.W., Tsang K.Y., Mills A.A., Cheung M.C.H. and Chan D., Role of p53/p63 in Chondrocyte Re-differentiation upon Activation of ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Scott C.E., Wynn S.L., Sesay A., Cruz C., Cheung M.C.H., Gaviro M.-.V. .G., Booth S., Gao B., Cheah K.S.E., Lovell-Badge R. and Briscoe J., Sox9 induces and maintains neural stem cells, Nature Neuroscience. 2010, 13: 1181-1189. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Researcher : Cheung YW |
| List of Research Outputs |
| Cheung Y.W. and Tanner J.A., Development of Nucleic Acid Aptamers against Plasmodium falciparum lactate dehydrogenase for improving the diagnosis of malaria, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Cheung Y.W. and Tanner J...A..., New avenues to malaria diagnosis – aptamers against P. falciparum histidine rich protein 2, FEBS Congress 2010, Gothenburg. 2010. |
| Cheung Y.W. and Tanner J...A..., Targeting glutamate synthase for tuberculosis drug development, Hong Kong Medical Journal. 2011, 17: 32-34. |
| Researcher : Chow MZY |
| List of Research Outputs |
| Krishnan V. and Chow M.Z.Y., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. , PNAS. 2011, 108(30): 12325-12330. |
| Researcher : Chu KH |
| List of Research Outputs |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Liu Y., Chu K.H. and Sham M.H., The /Irx3 /and /Irx5 /genes in inner ear development,, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Researcher : Cui J |
| List of Research Outputs |
| Cui J., Kinesin-1 in Pancreatic Beta Cell and Renal Epithelial Cell . 2011. |
| Cui J., Wang Z., Cheng Q., Lin R., Zhang X.M., Leung P.S., Copeland N.G., Jenkins N.A., Yao K.M. and Huang J., Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. , Diabetes. 2011, 60 (1): 320-330. |
| Researcher : Fan Y |
| List of Research Outputs |
| Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Gemome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in Southern China, 12th International Phillip Zorab Symposium, London, UK, March 16-18, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in southern China, 12th International Phillip Zorab Symposium, 2011 . 2011. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010. |
| Researcher : Fan Y |
| List of Research Outputs |
| Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Gemome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in Southern China, 12th International Phillip Zorab Symposium, London, UK, March 16-18, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in southern China, 12th International Phillip Zorab Symposium, 2011 . 2011. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010. |
| Researcher : Feng C |
| List of Research Outputs |
| Feng C., Chan D., Hu J., Stricker S.I.G.M.A.R. and Mundlos S.T.E.F.A.N., Role of IHH Signaling in the Progression of Joint Formation in Digit Development , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2011. HK, 2010. |
| Researcher : Gan H |
| List of Research Outputs |
| Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Necessary for Chondrocyte Cytokinesis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Gao Y |
| List of Research Outputs |
| Gao Y., Type IIA Procollagen and the Regulation of Nodal Signaling. 2011. |
| Researcher : Guan XY |
| Project Title: | 49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 10/1999 |
| Project Title: | 51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 10/2001 |
| Project Title: | Characterization of role and mechanism of eIF-5A2 in tumor metastasis |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2007 |
| Completion Date: | 09/2010 |
| Project Title: | Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 03/2009 |
| Project Title: | Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 03/2009 |
| Project Title: | Characterization of metastatic role of CHD1L in hepatocellular carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Project Title: | Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2011 |
| Project Title: | 102nd Annual Meeting of American ASSociation for Cancer Research Wnt2 Secreted by Tumor Fibroblasts Promotes Tumor Growth and Cell Motility in Esophageal Carcinoma |
| Investigator(s): | Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 04/2011 |
| Completion Date: | 04/2011 |
| List of Research Outputs |
| He L.R., Liu M.Z., Li B.K., Jia W.H., Zhang Y., Liao Y.J., Chen Y.C., Zhang L.G., Guan X.Y., Zeng Y.X., Kung H.F. and Xie D., High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy., International Journal of Cancer. 2010, 127: 138-147. |
| He L.R., Zhao H.Y., LI B.K., Zhang L.J., Liu M.Z., Kung H.F., Guan X.Y., Bian X.W., Zeng Y.X. and Xie D., Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients., Ann Oncol . 2010, 21: 1675-1681. |
| Lee N.P.Y., Tsang F.H., Shek F.H., Mao M., Dai H., Zhang C., Dong S., Guan X.Y., Poon R.T.P. and Luk J.M.C., Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma., International Journal of Cancer. 2010, 127: 968-976. |
| Researcher : Guo S |
| Project Title: | Investigating the role of cell-matrix interactions mediated by ß1 integrin in notochord cell polarity and cell migration |
| Investigator(s): | Guo S, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Cheah K.S.E., Guo S., Wynn S., Au Y.K., Aszodi A., Fassler R. and Chan D., Lack of 1 integrin in the developing mouse notochord results in hemivertebrae. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011.. 2011. |
| Guo S., Wynn S...L..., Au Y.K., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of beta1 integrin results in hemivertebrae development in mice, Functional Genomics Next Generation Applicaitons & Technologies, February 3-4, 2011, DECHEMA-Haus. Frankfurt am Main. Germany. 2011. |
| Researcher : Ho BS |
| List of Research Outputs |
| Ho B.S., Cheng C.C.W., Leung K.K.H., Cheah K.S.E. and Koopman P., The Role of Sox2 and Sox18 in Mouse Hair Cycle and Specification , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Researcher : Ho DWH |
| List of Research Outputs |
| Cheung K.M.C., Ho D.W.H. and Song Y., Genetics: Evaluation of the Growing Child, In: Behrooz A. Akbarnia, MD Muharrem Yazici, MD George H. Thompson, MD , Growing Spine: Management of Spinal Disorders in young child . 2010. |
| Cheung K.M.C., Samartzis D., Karppinen J., Mok P.S., Ho D.W.H. and Fong D.Y.T., Invertebral disc degeneration: new insights based on "skipped" level disc pathology, Arthritis & Rheumatism. 2010, 62(8): 2392-2400. |
| Researcher : Hor HH |
| List of Research Outputs |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Researcher : Hu J |
| List of Research Outputs |
| Feng C., Chan D., Hu J., Stricker S.I.G.M.A.R. and Mundlos S.T.E.F.A.N., Role of IHH Signaling in the Progression of Joint Formation in Digit Development , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2011. HK, 2010. |
| Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K.F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range, Research Output Prize, The University of Hong Kong. 2010. |
| Ma G., Yu J., Chan D., Gao B., Hu J., He Y., Guo S., Zhou J., Zhang L., Kang Y., Cheah K.S.E., Feng G., Guo X., Wang Y., Zhou C.Z. and He L., Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels, Cell Res (in press doi:10.1038/cr.2011.76) . 2011. |
| Researcher : Hua Y |
| List of Research Outputs |
| Zheng S., Yu B., Hua Y., Yuen K.Y., Zheng B. and Huang J., Development of Live Recombinant Salmonella Oral Vaccine against Avian Influenza Viruses, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Huang J |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of bacteria-mediated oral vaccine against highly pathogenic avian influenza viruses for veterinary use |
| Investigator(s): | Huang J, Yuen KY, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2007 |
| Project Title: | Toward a Bioshield against Influenza Virus Infection by Commensal Bacteria Secreting Antiviral Peptide |
| Investigator(s): | Huang J, Yuen KY, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2008 |
| Project Title: | Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 04/2009 |
| Completion Date: | 03/2012 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Study of kinesin-1-dependent transport of α-sarcomeric actin for myofibril assembly |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2011 |
| Project Title: | Programming Tumor-targeting Bacteria by Combinatorial Control |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2010 |
| Completion Date: | 06/2011 |
| Project Title: | Mechanistic study of the roles of kinesin-1 in myofibril assembly |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Programming the Second Generation Tumor-targeting Bacteria |
| Investigator(s): | Huang J, Cui X, Man K |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2011 |
| Project Title: | American Physical Society March Meeting 2011 A tunable sequential and periodic pattern formed by coupling cell motility with density |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 03/2011 |
| Completion Date: | 03/2011 |
| Project Title: | Mechanistic study of reprogramming epithelial cells to form mesenchymal stem cells |
| Investigator(s): | Huang J, Cui J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199. |
| Chen W., Ho J.W.S., Huang J. and Watt R.M., Functional characterization of an alkaline exonuclease and single strand annealing protein from the SXT genetic element of Vibrio cholerae, BMC Molecular Biology. 2011, 12(1): 16. |
| Cui J., Wang Z., Cheng Q., Lin R., Zhang X.M., Leung P.S., Copeland N.G., Jenkins N.A., Yao K.M. and Huang J., Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. , Diabetes. 2011, 60 (1): 320-330. |
| Durairajan S.S.K., Liu L.F., Lu J.H., Koo I., Maruyama K., Chung S.K., Huang J. and Li M., Stimulation of non-amyloidogenic processing of amyloid-b protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-a, Journal of Alzheimer's Disease. 2011, 25: 245-262. |
| Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Necessary for Chondrocyte Cytokinesis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Huang J., Frontiers in Predictive Toxicity, Frontiers Media S.A., 2010. |
| Lin R., Huang J. and Fung M.L., KIF5b Interaction with NMDA Receptor Mediates NO Production in Neuron, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lu J.H., Ardah M.T., Durairajan S.S.K., Liu L.F., Xie L.X., Fong W.F.D., Hasan M.Y., Huang J., El-Agnaf O.M.A. and Li M., Baicalein Inhibits Formation of a-Synuclein Oligomers within Living Cells and Prevents Ab Peptide Fibrillation and Oligomerisation. , Chem BioChem . 2011, 12: 615-624. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Yu B., Yang M. and Huang J., Engineering Tumor Targeting Salmonella , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zheng S., Yu B., Hua Y., Yuen K.Y., Zheng B. and Huang J., Development of Live Recombinant Salmonella Oral Vaccine against Avian Influenza Viruses, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Huang J. |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of bacteria-mediated oral vaccine against highly pathogenic avian influenza viruses for veterinary use |
| Investigator(s): | Huang J, Yuen KY, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2007 |
| Project Title: | Toward a Bioshield against Influenza Virus Infection by Commensal Bacteria Secreting Antiviral Peptide |
| Investigator(s): | Huang J, Yuen KY, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2008 |
| Project Title: | Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 04/2009 |
| Completion Date: | 03/2012 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Study of kinesin-1-dependent transport of α-sarcomeric actin for myofibril assembly |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2011 |
| Project Title: | Programming Tumor-targeting Bacteria by Combinatorial Control |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2010 |
| Completion Date: | 06/2011 |
| Project Title: | Mechanistic study of the roles of kinesin-1 in myofibril assembly |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Programming the Second Generation Tumor-targeting Bacteria |
| Investigator(s): | Huang J, Cui X, Man K |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2011 |
| Project Title: | American Physical Society March Meeting 2011 A tunable sequential and periodic pattern formed by coupling cell motility with density |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 03/2011 |
| Completion Date: | 03/2011 |
| Project Title: | Mechanistic study of reprogramming epithelial cells to form mesenchymal stem cells |
| Investigator(s): | Huang J, Cui J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Researcher : Hui CC |
| List of Research Outputs |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Researcher : Ikegawa S |
| List of Research Outputs |
| Chan W.C.W., Zhang L., Chan T., Ikegawa S., Cheung K.M.C., Cheah K.S.E. and Chan D., ER-stress induces early onset intervertebral disc degeneration in a mouse model for metaphyseal chondrodysplasia type Schmid, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Researcher : Ip CH |
| List of Research Outputs |
| Ip C.H., Chan C.H. and Shum D.K.Y., Implication in the Role of Serglycin in Neutrophils: Retention of Neutrophil Elastase in Granules and Inhibition of Neutrophil Elastase Activity during Storage , American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Binds Serglycin During Storage in Granules and Changes its Binding Partner to Shed Syndecan-1 after Degranulation , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Changes its Binding Partner following Neutrophil Degranulation in Airway Inflammation , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Researcher : Ip CH |
| List of Research Outputs |
| Ip C.H., Chan C.H. and Shum D.K.Y., Implication in the Role of Serglycin in Neutrophils: Retention of Neutrophil Elastase in Granules and Inhibition of Neutrophil Elastase Activity during Storage , American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Binds Serglycin During Storage in Granules and Changes its Binding Partner to Shed Syndecan-1 after Degranulation , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Changes its Binding Partner following Neutrophil Degranulation in Airway Inflammation , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Researcher : Jia Y |
| List of Research Outputs |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Clustering Ortholog Groups in Transcript Level, International Conference on Bioinformatics (InCoB 2010). 2010. |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Investigation of the Lineage and Tissue Specificity of Genes, The 11th International Conference on Bioinformatics and Computational Biology (BIOCOMP ’10). 2010. |
| Jia Y., Wong K.F., Song Y., Yiu S.M. and Smith D., Refining Ortholog Groups at the Transcript Level, BMC Genomics. 2010, 11 (Suppl 4): S11. |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis |
| Investigator(s): | Jin D, Ching YP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Roles and regulation of yeast peroxiredoxins in antioxidant defense and in the maintenance of genome stability |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Completion Date: | 12/2010 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | Roles and regulation of MIP-T3 in centrosomal and ciliary function |
| Investigator(s): | Jin D, Ching YP, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2009 |
| Completion Date: | 12/2011 |
| Project Title: | Posttranslational modifications of TORC transcriptional coactivators and implications in HTLV-1 pathogenesis |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Characterization of a novel cellular target of Epstein-Barr virus-encoded miRNA miR-BART3 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2009 |
| Completion Date: | 04/2011 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Identification and characterization of the cellular targets of miR-BART5, an Epstein-Barr virus-encoded microRNA |
| Investigator(s): | Jin D, Kok KH, Tsao GSW |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Regulatory roles of dsRNA-binding proteins PACT and TRBP in antiviral innate immunity |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | The 29th Annual Metting of the American Society for Virology Group I p21-activated kinases are required for optimal activation of human T cell leukemia virus type 1 long terminal repeats by viral oncoprotein Tax |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2010 |
| Completion Date: | 07/2010 |
| Project Title: | Roles of dsRNA-binding protein PACT in RIG-I dependent innate antiviral immunity |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Modulation of cell signalling by human coronavirus HKU1 S and M proteins |
| Investigator(s): | Jin D, Woo PCY |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Kinetochore localization and function of a structural component of the nuclear pore complex |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | RIG-I and MDA5 agonists as vaccine adjuvants |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2011 |
| List of Research Outputs |
| Chan C.P., Kok K.H. and Jin D., CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models, Cell & Bioscience. 2011, 1: 6. |
| Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010. |
| Jin D., Chan C.P. and Siu Y.T., Group I p21-activated kinases are required for optimal activation of human T cell leukemia virus type 1 long terminal repeats by viral oncoprotein Tax, The American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, Montana, USA, July 17-21, 2010.. 2010. |
| Kok K.H. and Jin D., Double-stranded RNA-binding protein PACT is a potent activator of RIG-I-dependent innate antiviral response, American Society for Virology, 29th Annual Meeting, Montana State University, Bozeman Montana, USA. 2010. |
| Kok K.H., Lei T. and Jin D., Identification and Validation of the Cellular Targets of Virus-Encoded MicroRNAs, In: Silvia Monticelli, MicroRNAs and the Immune System: Methods and Protocols, Methods in Molecular Biology. Springer, 2010, 667. |
| Kok K.H., Lui P.Y., Ng M.H., Siu K.L., Au S.W. and Jin D., The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response, Cell Host Microbe. 2011, 9: 299-309. |
| Li Y., Chu L.W., Wang B., Yik P.Y., Huriletemuer I., Jin D., Ma X. and Song Y., Cyp46a1 Functional Promoter Haplotypes Decipher Genetic Susceptibility To Alzheimer's Disease, Journal Of Alzheimer's Disease. IOS Press, 2010, 21(4): 1311-23. |
| Mak T.Y., Chan C.P. and Jin D., Comparative Analysis of bZIP Transcription Factors of the CREB3 Subfamily , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tang V.H.M., Siu K.L., Wong C.M. and Jin D., Role of yeast peroxiredoxin, Tsa1p, in DNA damage response, Keystone Symposia Conference, Genomic Instability and DNA Repair. Keystone Symposia, Keystone, Colorado, USA.. 2011. |
| Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4). |
| Wong K.Y., Liang R.H.S., So J.C.C., Jin D., Costello J.F. and Chim J.C.S., Epigenetic silencing of MIR203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print]. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 and c-Myb in Beta-Amyloid Toxicity and Alzheimer’s Disease, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid Toxicity and Alzheimer’s Disease, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Jin G |
| Project Title: | MT1-MMP in the regulation of stem cell niches |
| Investigator(s): | Jin G, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| Researcher : Jin G |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Jin Y |
| Project Title: | Cell-to-cell coupling mediated seamless genetic engineering |
| Investigator(s): | Jin Y, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 07/2010 |
| Researcher : Kao PYP |
| List of Research Outputs |
| Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., A knowledge-based weighting approach to boost power of genome-wide association studies., PlosOne. 2010, 5(12): e14480. |
| Researcher : Kok KH |
| Project Title: | 29th Annual Meeting of the American Society for Virology Double-stranded RNA-binding protein PACT is a potent activator of RIG-I-dependent innate antiviral response |
| Investigator(s): | Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2010 |
| Completion Date: | 07/2010 |
| Project Title: | Dominant negative role of a naturally-occurring alternatively spliced variant of TAR-binding protein in miRNA-mediated gene silencing |
| Investigator(s): | Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2011 |
| Project Title: | Inhibition of RIG-I-dependent innate immunity by herpes simplex virus type 1 Us11 protein |
| Investigator(s): | Kok KH, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Chan C.P., Kok K.H. and Jin D., CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models, Cell & Bioscience. 2011, 1: 6. |
| Kok K.H., Academic editor, PLoS ONE. 2011. |
| Kok K.H., Double-stranded RNA binding protein PACT is a potent activator of RIG-I-dependent innate antiviral response., American Society for Virology Postdoctoral Travel Award. 2010. |
| Kok K.H. and Jin D., Double-stranded RNA-binding protein PACT is a potent activator of RIG-I-dependent innate antiviral response, American Society for Virology, 29th Annual Meeting, Montana State University, Bozeman Montana, USA. 2010. |
| Kok K.H., Lei T. and Jin D., Identification and Validation of the Cellular Targets of Virus-Encoded MicroRNAs, In: Silvia Monticelli, MicroRNAs and the Immune System: Methods and Protocols, Methods in Molecular Biology. Springer, 2010, 667. |
| Kok K.H., Postdoctoral Travel Award, American Society for Virology. 2010. |
| Kok K.H., Lui P.Y., Ng M.H., Siu K.L., Au S.W. and Jin D., The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response, Cell Host Microbe. 2011, 9: 299-309. |
| Researcher : Kwok CST |
| List of Research Outputs |
| Kwok C.S.T., Wu M.H., Cheung M.C.H., Herve A. and Nieto M.A., The Role of SoxE Transcription Factors in Melanoma Development , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Lam D |
| List of Research Outputs |
| Lam D. and Wong N.S., A Proposed Model for UPR-mediated Cellular Survival and Cell Death , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lam D. and Wong N.S., Intracellular ROS enhances the survival of cells under the conditions of ER stress, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium . 2011. |
| Researcher : Lam D |
| List of Research Outputs |
| Lam D. and Wong N.S., A Proposed Model for UPR-mediated Cellular Survival and Cell Death , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lam D. and Wong N.S., Intracellular ROS enhances the survival of cells under the conditions of ER stress, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium . 2011. |
| Researcher : Lam TK |
| List of Research Outputs |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Researcher : Lam VMS |
| Project Title: | 18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2000 |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 04/2002 |
| Project Title: | 7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2003 |
| Researcher : Lam YL |
| List of Research Outputs |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th Int’l Symp. on Healthy Aging: 68. 2011. |
| Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 68. [HK. March 5-6, 2011]. 2011. |
| Researcher : Lam YM |
| List of Research Outputs |
| Lam Y.M., Tang D., Chu S.L., Nal-Rogier B.T.M., Bruzzone R. and Lam C.H.P., Identification of Molecular Determinants for Efficient H5pp, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Lee KS |
| List of Research Outputs |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for Osteoarthritis and Degenerative Disc Disease. , 2010 World Forum of Spine Research, Montreal, Canada, July 5-8, 2010.. 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011. . 2011. |
| Researcher : Lee KS |
| List of Research Outputs |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for Osteoarthritis and Degenerative Disc Disease. , 2010 World Forum of Spine Research, Montreal, Canada, July 5-8, 2010.. 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011. . 2011. |
| Researcher : Lei IL |
| List of Research Outputs |
| Lei I.L., Gao X.L., Sham M.H. and Wang Z., BAF250a is Required for Secondary Heart Field Development , 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Researcher : Lei T |
| Project Title: | A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis |
| Investigator(s): | Lei T, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| Project Title: | 29th Annual Meeting of the American Society for Virology Epstein-Barr virus-encoded microRNA miR-BART3 targets tumor suppressor INTS6 to stimulate host cell proliferation |
| Investigator(s): | Lei T |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2010 |
| Completion Date: | 07/2010 |
| List of Research Outputs |
| Kok K.H., Lei T. and Jin D., Identification and Validation of the Cellular Targets of Virus-Encoded MicroRNAs, In: Silvia Monticelli, MicroRNAs and the Immune System: Methods and Protocols, Methods in Molecular Biology. Springer, 2010, 667. |
| Lei T., Epstein-Barr virus encoded microRNA miR-BART3 targets tumor suppressor INTS6 to stimulate host cell proliferation, American Society for Virology Postdoctoral Travel Award. 2010. |
| Researcher : Leung C |
| List of Research Outputs |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Differential regulation of retinoic acid signaling in adult spinal cord neural progenitors., 9th Annual International Society of Stem Cell Research Meeting, Toronto, Canada, June 15-18, 2011. |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Beverly McKinnell Award , The 16th International Conference of the International Society of Differentiation. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 mutation affects enteric neural crest cell migration in a cell autonomous manner, Differentiation. 2010, 80: S23. |
| Researcher : Leung C.M. |
| List of Research Outputs |
| Shum K...T..., Chan S.L.C., Leung C...M... and Tanner J...A..., Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signaling, Biochemical Journal. 2011, 434: 501-510. |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Researcher : Leung GWY |
| List of Research Outputs |
| Ma R.Y., Tong T.H., Leung G.W.Y. and Yao K.M., Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1, In: Paul J. Higgins, Methods Mol Biol. Springer New York, Humana Press, 2010, 647: 113-123. |
| Researcher : Leung HY |
| List of Research Outputs |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Cell-intrinsic switch to the fate commitment of bone marrow-derived Schwann cells, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 59. [HK. March 5-6, 2011]. 2011. |
| Researcher : Leung KKH |
| List of Research Outputs |
| Ho B.S., Cheng C.C.W., Leung K.K.H., Cheah K.S.E. and Koopman P., The Role of Sox2 and Sox18 in Mouse Hair Cycle and Specification , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Leung K.K.H., Transgenic Mouse Technology, Laboratory Animail Unit, The University of Hong Kong. 2011. |
| Researcher : Leung VOY |
| List of Research Outputs |
| Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Researcher : Leung WL |
| List of Research Outputs |
| Leung W.L., Wong S.Y., Chan D., Tam P.P.L. and Cheah K.S.E., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain, Developmental Dynamics. 2010, 239: 2319-2329. |
| Researcher : Li J |
| List of Research Outputs |
| Li J., Sham P.C. and Wang J.J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, Bioinformatics. 2010, 26: 2897-2899. |
| Li J. and Cheah K.S.E., Tissue-specific Transcriptional Regulation of Sox2 Expression in Mouse Inner Ear Development, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor, Nucleic Acids Research. 2011, 39: W430-W436. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Researcher : Li J |
| List of Research Outputs |
| Li J., Sham P.C. and Wang J.J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, Bioinformatics. 2010, 26: 2897-2899. |
| Li J. and Cheah K.S.E., Tissue-specific Transcriptional Regulation of Sox2 Expression in Mouse Inner Ear Development, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor, Nucleic Acids Research. 2011, 39: W430-W436. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Researcher : Li L |
| List of Research Outputs |
| Li L., Lui E.L.H. and Tanner J.A., Inorganic polyphosphate and bone - new roles for an ancient molecule, 无机多磷酸盐和骨－一种古老分子的新作用, University Lyon 1. 里昂第一大学, 2011. |
| Lui E.L.H., Li L. and Tanner J.A., Inorganic Polyphosphate and its Impact on Osteoblast Function, Signaling and Gene Expression , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Li L. |
| List of Research Outputs |
| Lui L.H.E., Li L... and Tanner J...A..., Impact of Extracellular Inorganic Polyphosphate on Osteoblast Proliferation, Differentiation and Apoptosis, International Biotechnology Innovation Conference, Cairo. Egypt, 2011. |
| Researcher : Li M |
| List of Research Outputs |
| Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., A knowledge-based weighting approach to boost power of genome-wide association studies., PlosOne. 2010, 5(12): e14480. |
| Li M., Chan Y.S. and Shum D.K.Y., Expression of chondroitin sulfotransfgerases in relation to cranial motor neuron migration, Abstracts of 6th International Symposium on on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010. |
| Researcher : Li M |
| List of Research Outputs |
| Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., A knowledge-based weighting approach to boost power of genome-wide association studies., PlosOne. 2010, 5(12): e14480. |
| Li M., Chan Y.S. and Shum D.K.Y., Expression of chondroitin sulfotransfgerases in relation to cranial motor neuron migration, Abstracts of 6th International Symposium on on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010. |
| Researcher : Li Y |
| List of Research Outputs |
| Li Y., Chu L.W., Wang B., Yik P.Y., Huriletemuer I., Jin D., Ma X. and Song Y., Cyp46a1 Functional Promoter Haplotypes Decipher Genetic Susceptibility To Alzheimer's Disease, Journal Of Alzheimer's Disease. IOS Press, 2010, 21(4): 1311-23. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Researcher : Lie YS |
| List of Research Outputs |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Researcher : Lie YS |
| List of Research Outputs |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Researcher : Lin R |
| List of Research Outputs |
| Lin R., Huang J. and Fung M.L., KIF5b Interaction with NMDA Receptor Mediates NO Production in Neuron, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Liu B |
| Project Title: | Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice |
| Investigator(s): | Liu B, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2008 |
| Project Title: | Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2009 |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Liu B |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Liu D |
| List of Research Outputs |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Liu Y |
| List of Research Outputs |
| Liu Y., Chu K.H. and Sham M.H., The /Irx3 /and /Irx5 /genes in inner ear development,, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Researcher : Lovell-Badge RH |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Wynn S.A.R.A.H., Chan Y.S., Cheung K.M.C., Chan W...Y..., Lovell-Badge R.H., Chan D. and Fritzsch B..., Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation., The Fourth Annual Introductory Course on Skeletal Dysplasias, an international course for phycisians and scientists, Freiburg, Germany, 8 July, 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Researcher : Lu L |
| List of Research Outputs |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Researcher : Lui E.L.H. |
| List of Research Outputs |
| Shum K...T..., Lui E...L...H..., Wong C...K...S..., Yeung P..., Sam L..., Wang Y..., Watt R...M... and Tanner J...A..., Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2, Biochemistry. 2011, 50: 3261-3271. |
| Researcher : Lui ELH |
| List of Research Outputs |
| Li L., Lui E.L.H. and Tanner J.A., Inorganic polyphosphate and bone - new roles for an ancient molecule, 无机多磷酸盐和骨－一种古老分子的新作用, University Lyon 1. 里昂第一大学, 2011. |
| Lui E.L.H., Li L. and Tanner J.A., Inorganic Polyphosphate and its Impact on Osteoblast Function, Signaling and Gene Expression , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Lui LHE |
| List of Research Outputs |
| Lui L.H.E., Li L... and Tanner J...A..., Impact of Extracellular Inorganic Polyphosphate on Osteoblast Proliferation, Differentiation and Apoptosis, International Biotechnology Innovation Conference, Cairo. Egypt, 2011. |
| Researcher : Lui PY |
| List of Research Outputs |
| Kok K.H., Lui P.Y., Ng M.H., Siu K.L., Au S.W. and Jin D., The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response, Cell Host Microbe. 2011, 9: 299-309. |
| Researcher : Lui TW |
| List of Research Outputs |
| Lui T.W. and Wong N.S., The Role of the AU-rich Element in the mRNA of the Stress-inducible Protein CHOP/Gadd153, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Lui WT |
| List of Research Outputs |
| Lui W.T. and Wong N.S., Functional significance of the 3’-UTR in the mRNA of the stress-inducible protein CHOP/Gadd153, HK Inter-University Biochemistry Postgraduate Symposium HK Inter-University Biochemistry Postgraduate Symposium 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium . 2011. |
| Researcher : Mak TY |
| List of Research Outputs |
| Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010. |
| Mak T.Y., Chan C.P. and Jin D., Comparative Analysis of bZIP Transcription Factors of the CREB3 Subfamily , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Mak TY |
| List of Research Outputs |
| Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010. |
| Mak T.Y., Chan C.P. and Jin D., Comparative Analysis of bZIP Transcription Factors of the CREB3 Subfamily , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Melhado IG |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol Biosynthesis is a Potential Pathway Involved in the Degeneration of the Annulus Fibrosus, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol biosynthesis is a potential pathway involved in the degeneration of the annulus fibrosus, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Yee F.Y.A., Melhado I.G., Cheah K.S.E., Cheung K.M.C. and Chan D., Transcriptome of the Human Intervertebral Disc in Health and Disease, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Researcher : Ng MH |
| Project Title: | Roles of Flightless-I associated proteins LRRFIP1 and LRRFIP2 in type-I interferon production |
| Investigator(s): | Ng MH, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Kok K.H., Lui P.Y., Ng M.H., Siu K.L., Au S.W. and Jin D., The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response, Cell Host Microbe. 2011, 9: 299-309. |
| Researcher : Ng VCW |
| List of Research Outputs |
| Klopocki E., Lohan S., Brancati F., Koll R., Brehm A., Seemann P., Dathe K., Stricker S., Hecht J., Bosse K., Betz R.C., Garaci F.G., Dallapiccola B., Jain M., Muenke M., Ng V.C.W., Chan W.C.W., Chan D. and Mundlos S., Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis., Am J Hum Genet. 2011, 88(1): 70-5. |
| Shen Y., Ng V.C.W., Cheung S.K.C., Shen W., Lam Y.W., Agata K., Chan B.P. and Chan D., The Study of Extracellular Matrix and Stem Cell Niche in Planarian, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Researcher : Ni Y |
| Project Title: | Novel role of Kif5b in clathrin uncoating |
| Investigator(s): | Ni Y, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2010 |
| Researcher : Niu B |
| Project Title: | Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate |
| Investigator(s): | Niu B, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Osorio Da Silva LA |
| Project Title: | Isthmin in early embryonic development and gastrulation |
| Investigator(s): | Osorio Da Silva LA, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2010 |
| Completion Date: | 10/2011 |
| Project Title: | Gordon Research Conference Developmental Biology Role of Isthmin in chick spinal cord development |
| Investigator(s): | Osorio Da Silva LA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 06/2011 |
| List of Research Outputs |
| Wu X., Osorio Da Silva L.A. and Zhou Z., Isthmin, a Novel Extracellular Regulator of Nodal Signaling , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Pei SLC |
| List of Research Outputs |
| Pei S.L.C., Chan W.C.W., Tsang K.Y., Mills A.A., Cheung M.C.H. and Chan D., Role of p53/p63 in Chondrocyte Re-differentiation upon Activation of ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Qi S |
| List of Research Outputs |
| Qi S., UreE-Hpn/Hpnl interaction in H. pylori, and the role of cysteines in Hpn. 2010. |
| Researcher : Qin J |
| List of Research Outputs |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Combinatory Analysis of ChIP-seq/chip and Microarray Gene Expression Data, High Throughput Biology, Cold Spring Harbor Asia, Suzhou, China, Apr 19-23. 2011. |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, Hong Kong, Jun 11 . 2011. |
| Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor, Nucleic Acids Research. 2011, 39: W430-W436. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Researcher : Sham MH |
| Project Title: | International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 09/2000 |
| Project Title: | Sonic hedgehog signaling and cross talks with Hox genes in hindbrain neurogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2008-2009 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2009 |
| Project Title: | The role of Irx3 and Irx5 homeobox genes in motor neurone specification |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2011 |
| Project Title: | Visiting Research Professors Scheme 2010-11 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2010 |
| Project Title: | Enteric neural crest cell migration in the developing gut: Molecular and cellular analyses of a Sox10 mouse mutant |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | International Society of Stem Cell Research 9th Annual Meeting DIFFERENTIAL REGULATION OF RETINOIC ACID SIGNALING IN ADULT SPINAL CORD NEURAL PROGENITORS |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 06/2011 |
| List of Research Outputs |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Lei I.L., Gao X.L., Sham M.H. and Wang Z., BAF250a is Required for Secondary Heart Field Development , 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Differential regulation of retinoic acid signaling in adult spinal cord neural progenitors., 9th Annual International Society of Stem Cell Research Meeting, Toronto, Canada, June 15-18, 2011. |
| Liu Y., Chu K.H. and Sham M.H., The /Irx3 /and /Irx5 /genes in inner ear development,, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Ma L., Zheng L., Sham M.H., Lam C.C.K., Zwahlen R.A. and Cheung L.K., Effect of platelet rich plasma on a rabbit model of nicotine compromised bone healing , J Oral Maxillofac Surg. 2010, 69: 28-35. |
| Ma L., Zwahlen R.A., Zheng L. and Sham M.H., Influence of nicotine on the biological activity of rabbit osteoblasts, Clin Oral Implants Res. 2011, 22: 338-42. |
| Sham M.H., A Sox10-GFP mouse model of Waardenburg-Hirschsprung syndrome. School of Life Sciences, Peking University, Beijing, PR China, April 30, 2011 (Invited Speaker). 2011. |
| Sham M.H. and Cai K., Angiogenesis and lung cancer: Antiangiogenic agent and therapy, In: Chatterjee M., Rana, A., Rana, B., Angiogenesis and Therapeutic Target of Cancer. Bentham Sci. Publ., 2010, 1. |
| Sham M.H., Member of the Academic Editorial Board, PLoS ONE. PLoS, 2010. |
| Sham M.H., Review Editor, Frontiers in Autonomic Neuroscience. 2011. |
| Sham M.H., Sox10 mutation affects enteric neural crest cell migration. 44th Annual Meeting for the Japanese Society of Developmental Biologist, Okinawa, Japan, May 18-21, 2011 (Invited Speaker). 2011. |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Tam C.N., Cheng M.H., Tsang S.L., Sham M.H., Yam G.H.F. and Pang C.P., A Mutant gA-crystallin Leads to Cataractogenesis through the Unfolded Protein Response, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang X., Chan A.K., Sham M.H., Burns A.J. and Chan W.Y., Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo, Gastroenterology. 2011, Epub ahead of print. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Wong E.Y.M., Wang X., Mak S.S., Sae-Pang J.J., Ling K.W., Fritzsch B. and Sham M.H., Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning, Developmental Biology. 2011, 352: 382-392. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Beverly McKinnell Award , The 16th International Conference of the International Society of Differentiation. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 mutation affects enteric neural crest cell migration in a cell autonomous manner, Differentiation. 2010, 80: S23. |
| Researcher : Shea GKH |
| List of Research Outputs |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Shea G.K.H., ErbB receptor modulation by the Notch pathway as a means to fate commitment in bone marrow-derived Schwann cells. 2011. |
| Shea G.K.H., Chan Y.S. and Shum D.K.Y., ErbB receptor modulation controls the fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 45. 2010. |
| Shum D.K.Y., Shea G.K.H., Tsui Y.P. and Chan Y.S., Directed differentiation of bone marrow stromal cells to fate commitment of Schwann cells for remyelination therapy. Annals Neuroscience, 17: 27. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies, Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Cell-intrinsic switch to the fate commitment of bone marrow-derived Schwann cells, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 59. [HK. March 5-6, 2011]. 2011. |
| Researcher : Shen Y |
| List of Research Outputs |
| Shen Y., Ng V.C.W., Cheung S.K.C., Shen W., Lam Y.W., Agata K., Chan B.P. and Chan D., The Study of Extracellular Matrix and Stem Cell Niche in Planarian, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 10/2007 |
| Project Title: | Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways |
| Investigator(s): | Shum DKY, Ip MSM, Chan CH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 12/2008 |
| Project Title: | Role of heparanase in synaptic plasticity at the vestibular nucleus |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | From bone marrow stromal cells to Schwann cells an in vitro route to specification |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | 40th Annual Meeting of Society for Neuroscience 2010 The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2010 |
| Completion Date: | 11/2010 |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan Conduits Seeded With Bone Marrow Stromal Cell-derived Schwann Cells Enhance Regeneration Of Rat Sciatic Nerve, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 65. 2010. |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Cai S., Ao Q., Chan Y.S. and Shum D.K.Y., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/ CXCR4, Annals Neuroscience, 17: 103. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Chan C.H., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Use of sulfated maltoheptaose to lower neutrophilic inflammation in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Chan Y.S., Lai S.K., Yamaguchi K. and Shum D.K.Y., Attentuation of cerebellar plasticity after neonatal perturbation of NMDA receptors in the vestibular nucleus., Journal of Neurochemistry, 115 (Suppl 1): 29-30. [10th Biennial Meeting of The Asia-Pacific Society for Neurochemistry. Phuket, Thailand. Oct. 17-20, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Implication in the Role of Serglycin in Neutrophils: Retention of Neutrophil Elastase in Granules and Inhibition of Neutrophil Elastase Activity during Storage , American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Binds Serglycin During Storage in Granules and Changes its Binding Partner to Shed Syndecan-1 after Degranulation , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Ip C.H., Chan C.H. and Shum D.K.Y., Neutrophil Elastase Changes its Binding Partner following Neutrophil Degranulation in Airway Inflammation , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011. |
| Lai S.K., Shum D.K.Y., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function, Society of Neuroscience Abstract (USA), 786.17/TT20. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th Int’l Symp. on Healthy Aging: 68. 2011. |
| Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 68. [HK. March 5-6, 2011]. 2011. |
| Li C.H., Chik T.K., Ngan A.H.W., Chan C.H., Shum D.K.Y. and Chan B.P., Correlation between compositional and mechanical properties of human mesenchymal stem cell-collagen microspheres during chondrogenic differentiation., Tissue Engineering Part A . 2011, 17(5-6): 777-788. |
| Li M., Chan Y.S. and Shum D.K.Y., Expression of chondroitin sulfotransfgerases in relation to cranial motor neuron migration, Abstracts of 6th International Symposium on on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Perineuronal net regulates synaptic plasticity of central circuitry, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60. 2010. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th Int’l Symp. on Healthy Aging: 57. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Shea G.K.H., Chan Y.S. and Shum D.K.Y., ErbB receptor modulation controls the fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 45. 2010. |
| Shum D.K.Y., Shea G.K.H., Tsui Y.P. and Chan Y.S., Directed differentiation of bone marrow stromal cells to fate commitment of Schwann cells for remyelination therapy. Annals Neuroscience, 17: 27. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies, Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Cell-intrinsic switch to the fate commitment of bone marrow-derived Schwann cells, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 59. [HK. March 5-6, 2011]. 2011. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Overcoming axon-restrictive chondroitin supphates with chondroitin sulphate lyases, Abstracts of 6th Int’l Symp. on Healthy Aging: A New Golden Age: 56. 2011. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyase subtypes to overcome molecular barriers of reactive glia: Implication for nerve regeneration, Proceedings of CSFR Neuroscience Summit, p. 32-33. [Beijing. Aug. 20-22, 2010]. 2010. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in combination for achieving maximal activity: Implication for nerve regeneration, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60-61. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: New perspective in CNS myelin repair, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 61-62. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards Myelin and Functional Recovery in the Injured CNS: Derivation of Oligodendrocyte Precursor Cells from Adult Bone Marrow Stromal Cells , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards functional recovery in the injured CNS: Generating oligodendrocyte precursors from bone marrow stromal cells for remyelination, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 63. [HK. March 5-6, 2011]. 2011. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards myelin repair in the CNS: Oligodendrocyte precursors derived from bone marrow stromal cells, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-e02. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Zhang F.X., Pang Y.W., Zhang M.M., Zhang T., Dong Y.L., Lai C.H., Shum D.K.Y., Chan Y.S., Li J.L. and Li Y.Q., Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat. , Neuroscience. 2011, 173: 179-189. |
| Researcher : Shum K.T. |
| List of Research Outputs |
| Shum K...T..., Lui E...L...H..., Wong C...K...S..., Yeung P..., Sam L..., Wang Y..., Watt R...M... and Tanner J...A..., Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2, Biochemistry. 2011, 50: 3261-3271. |
| Shum K...T..., Chan S.L.C., Leung C...M... and Tanner J...A..., Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signaling, Biochemical Journal. 2011, 434: 501-510. |
| Researcher : Shum KT |
| List of Research Outputs |
| Shum K.T., 2011 Johnson & Johnson Asia Outstanding Graduate Thesis Award in Bio-tech 2nd Prize , Johnson & Johnson Corporate Office of Science and Technology . 2011. |
| Shum K.T., A Comparative Study of G-Quadruplex Aptamers Against Multiple Protein Targets . 2010. |
| Shum K.T., Chan S.L.C. and Tanner J.A., Inhibiting sclerostin with a nucleic acid aptamer as a new approach to osteoporosis therapy, Johnson & Johnson Outstanding Graduate Thesis Award in Biotech One Day Symposium. 2011. |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, PCT Patent Application No. PCT/CN2011/000879 filed on 23 May 2011. 2011. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, U.S. Non-Provisional Application No. 13/116,244 filed on 26 May 2011. 2011. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Researcher : Shum KT |
| List of Research Outputs |
| Shum K.T., 2011 Johnson & Johnson Asia Outstanding Graduate Thesis Award in Bio-tech 2nd Prize , Johnson & Johnson Corporate Office of Science and Technology . 2011. |
| Shum K.T., A Comparative Study of G-Quadruplex Aptamers Against Multiple Protein Targets . 2010. |
| Shum K.T., Chan S.L.C. and Tanner J.A., Inhibiting sclerostin with a nucleic acid aptamer as a new approach to osteoporosis therapy, Johnson & Johnson Outstanding Graduate Thesis Award in Biotech One Day Symposium. 2011. |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, PCT Patent Application No. PCT/CN2011/000879 filed on 23 May 2011. 2011. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, U.S. Non-Provisional Application No. 13/116,244 filed on 26 May 2011. 2011. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Researcher : Siu KL |
| List of Research Outputs |
| Kok K.H., Lui P.Y., Ng M.H., Siu K.L., Au S.W. and Jin D., The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response, Cell Host Microbe. 2011, 9: 299-309. |
| Lin Y., Siu K.L., Tanner J.A. and Zheng B., Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein., 3rd International Conference on Drug Discovery & Therapy. . Dubai, UAE., 2011. |
| Tang V.H.M., Siu K.L., Wong C.M. and Jin D., Role of yeast peroxiredoxin, Tsa1p, in DNA damage response, Keystone Symposia Conference, Genomic Instability and DNA Repair. Keystone Symposia, Keystone, Colorado, USA.. 2011. |
| Researcher : Siu YT |
| List of Research Outputs |
| Jin D., Chan C.P. and Siu Y.T., Group I p21-activated kinases are required for optimal activation of human T cell leukemia virus type 1 long terminal repeats by viral oncoprotein Tax, The American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, Montana, USA, July 17-21, 2010.. 2010. |
| Researcher : Smith DK |
| Project Title: | Patterns in proteins with unusual flexibility profiles |
| Investigator(s): | Smith DK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 08/2002 |
| List of Research Outputs |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Clustering Ortholog Groups in Transcript Level, International Conference on Bioinformatics (InCoB 2010). 2010. |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Investigation of the Lineage and Tissue Specificity of Genes, The 11th International Conference on Bioinformatics and Computational Biology (BIOCOMP ’10). 2010. |
| Researcher : Song Y |
| Project Title: | A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Fine mapping candidate loci for nasopharyngeal carcinoma (NPC) in southern Chinese specifically linked to EBV aetiopathogenesis |
| Investigator(s): | Song Y, Guan X, Chua DTT |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2009 |
| Project Title: | Detecting genes and functional analysis of a novel gene (Cer1) significantly associated with bone mineral density (BMD) in mice. |
| Investigator(s): | Song Y, Chan D, Sham PC, Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Whole Genome-wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese |
| Investigator(s): | Song Y, Cheung KMC, Sham PC, Chan D, Luk KDK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2009 |
| Completion Date: | 04/2011 |
| Project Title: | The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis in Alzheimer's Disease |
| Investigator(s): | Song Y, Chu LW |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2010 |
| Completion Date: | 12/2010 |
| Project Title: | 60th Annual Meeting of the American Society of Human Genetics Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2010 |
| Completion Date: | 11/2010 |
| Project Title: | Identification of small molecule inhibitors of Pax6 in neuronal apoptosis of Alzheimer’s Disease |
| Investigator(s): | Song Y, Kao RYT, Chu LW, Zhang Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 12/2010 |
| Completion Date: | 11/2011 |
| Project Title: | Identification of a genetic variant for heart defects (CHD) in mice, which is a susceptibility factor for CHD in human |
| Investigator(s): | Song Y, Cheah KSE, Sham PC |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Bao S., Jiang R. and Song Y., Evaluation of Next Generation Sequencing software in mapping and assembly, PRAGMA19. 2010. |
| Bao S., Jiang R., Kwan W.K., Wang B., Ma X. and Song Y., Evaluation of next-generation sequencing software in mapping and assembly, J Hum Genet. 2011, 56: 406-414. |
| Bao S. and Song Y., Identification of "Stemness" Genes by Integrating Differentially Expressed Genes from Multiple Stem Cell Microarray Databsets, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2011. HK, 2010. |
| Chai L., Song Y., Zee K.Y. and Leung W.K., SNPs of Fc-gamma receptor genes and chronic periodontitis, J Dent Res. 2010, 89(7):: 705-10. |
| Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Cheung K.M.C., Ho D.W.H. and Song Y., Genetics: Evaluation of the Growing Child, In: Behrooz A. Akbarnia, MD Muharrem Yazici, MD George H. Thompson, MD , Growing Spine: Management of Spinal Disorders in young child . 2010. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Gemome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in Southern China, 12th International Phillip Zorab Symposium, London, UK, March 16-18, 2011. |
| Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-wide association study of adolescent idiopathic scoliosis in southern China, 12th International Phillip Zorab Symposium, 2011 . 2011. |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Clustering Ortholog Groups in Transcript Level, International Conference on Bioinformatics (InCoB 2010). 2010. |
| Jia Y., Wong K.F., Song Y., Smith D.K. and Yiu S.M., Investigation of the Lineage and Tissue Specificity of Genes, The 11th International Conference on Bioinformatics and Computational Biology (BIOCOMP ’10). 2010. |
| Jia Y., Wong K.F., Song Y., Yiu S.M. and Smith D., Refining Ortholog Groups at the Transcript Level, BMC Genomics. 2010, 11 (Suppl 4): S11. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In Vivo Study of Asporin, A Genetic Risk Factor Associated with Degenerative Disc Diseases , 15th Research Postgraduate Symposium, HKU, Dec 1 & 2, 2010. HK. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for Osteoarthritis and Degenerative Disc Disease. , 2010 World Forum of Spine Research, Montreal, Canada, July 5-8, 2010.. 2010. |
| Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011. . 2011. |
| Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., A knowledge-based weighting approach to boost power of genome-wide association studies., PlosOne. 2010, 5(12): e14480. |
| Li Y., Chu L.W., Wang B., Yik P.Y., Huriletemuer I., Jin D., Ma X. and Song Y., Cyp46a1 Functional Promoter Haplotypes Decipher Genetic Susceptibility To Alzheimer's Disease, Journal Of Alzheimer's Disease. IOS Press, 2010, 21(4): 1311-23. |
| Li Y., Fu L., Wong A.M.G., Fan Y., Li M., Bei J.X., Jia W.H., Zeng Y.X., Chan D., Cheung K.M.C., Sham P.C., Chua D.T.T., Guan X. and Song Y., Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. , PLoS One. 2011, 6(1): e14562. |
| Song Y., Fu L., Fan Y., Wong A.M.G., Li M., Guan X. and Song Y., Association of Chromosome 6p Multiple Regions with Nasopharyngeal Carcinoma and Gene Expression Changes in Cancer Tissue, ASHG 2010 Annual Meeting. 2010. |
| Song Y., Genome-wide association study of Scoliosis in Southern Chinese. , Annual Meeting of the Fondation Cotrel - Institut de France , 2010. 2010. |
| Song Y., Genome‐Wide Association Study (GWAS) of Adolescent Idiopathic Scoliosis (AIS), Forum on Strategic Research Themes in Biomedicine. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 and c-Myb in Beta-Amyloid Toxicity and Alzheimer’s Disease, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid Toxicity and Alzheimer’s Disease, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Sze KL |
| List of Research Outputs |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Generation of a mouse model to study ADAMTS-5 as a genetic risk factor for intervertebral disc degeneration, Basic science GSC2011-ABS-1530,Global Spine Congress 2011, Barcelona, Spain, March 23-26, 2011.. 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D.R., Cheah K.S.E., Cheung K.M.C. and Chan D., Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011. . 2011. |
| Sze K.L., Nagy A., Fosang A., McCulloch D., Cheah K.S.E., Cheung K.M.C. and Chan D., Poster presentation: Impact of Activating ADAMTS-5 in Cartilage-related Degenerative Disorders , World Forum for Spine Research, Montreal, Canada, 05 Jul 2010 - 08 Jul 2010. |
| Researcher : Szeto YY |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Researcher : Tam CN |
| List of Research Outputs |
| Tam C.N., Cheng M.H., Tsang S.L., Sham M.H., Yam G.H.F. and Pang C.P., A Mutant gA-crystallin Leads to Cataractogenesis through the Unfolded Protein Response, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Researcher : Tam JWO |
| Project Title: | 14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis |
| Investigator(s): | Tam JWO |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/1999 |
| Researcher : Tam PPL |
| List of Research Outputs |
| Leung W.L., Wong S.Y., Chan D., Tam P.P.L. and Cheah K.S.E., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain, Developmental Dynamics. 2010, 239: 2319-2329. |
| Researcher : Tan Z |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Tan Z |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Tang HC |
| List of Research Outputs |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Researcher : Tang VHM |
| Project Title: | 2011 Keystone Symposia Conference on Genomic Instability and DNA Repair (B4) Role of yeast peroxiredoxin, Tsa1p, in DNA damage response |
| Investigator(s): | Tang VHM |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 01/2011 |
| Completion Date: | 02/2011 |
| List of Research Outputs |
| Tang V.H.M., Siu K.L., Wong C.M. and Jin D., Role of yeast peroxiredoxin, Tsa1p, in DNA damage response, Keystone Symposia Conference, Genomic Instability and DNA Repair. Keystone Symposia, Keystone, Colorado, USA.. 2011. |
| Researcher : Tanner J.A. |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Identification, validation and characterization of the eukaryotic enzymes and regulators of inorganic polyphosphate metabolism |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Development of an Aptamer-Nanoparticle Based Rapid Diagnostic Test for Malaria |
| Investigator(s): | Tanner JA, Sun H |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis |
| Investigator(s): | Tanner JA, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Investigation of the interplay of polyphosphates and matrix vesicles in bone mineralization |
| Investigator(s): | Tanner JA, Li L |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Albano D.R.B., Tanner J...A... and Fung Y...S..., Aptamer-based piezoelectric quartz crystal biosensor for the SARS coronavirus helicase, 17th Symposium on Chemistry Postgraduate Research. Hong Kong, 2010. |
| Albano D.R.B., Tanner J...A... and Fung Y...S..., Piezoelectric quartz crystal biosensor for SARS coronavirus helicase based on aptamer, 10th Asia-Pacific International Symposium on Microscale Separation and Analysis. Hong Kong, 2010. |
| Chan W...L..., Lau E., Chan D..., Chu I...K..., Cheah K...S...E... and Tanner J...A..., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes, Human Proteome Organization Meeting HUPO2010, Sydney. Australia, 2010. |
| Cheung Y.W. and Tanner J...A..., New avenues to malaria diagnosis – aptamers against P. falciparum histidine rich protein 2, FEBS Congress 2010, Gothenburg. 2010. |
| Cheung Y.W. and Tanner J...A..., Targeting glutamate synthase for tuberculosis drug development, Hong Kong Medical Journal. 2011, 17: 32-34. |
| Lui L.H.E., Li L... and Tanner J...A..., Impact of Extracellular Inorganic Polyphosphate on Osteoblast Proliferation, Differentiation and Apoptosis, International Biotechnology Innovation Conference, Cairo. Egypt, 2011. |
| Shum K...T..., Lui E...L...H..., Wong C...K...S..., Yeung P..., Sam L..., Wang Y..., Watt R...M... and Tanner J...A..., Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2, Biochemistry. 2011, 50: 3261-3271. |
| Shum K...T..., Chan S.L.C., Leung C...M... and Tanner J...A..., Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signaling, Biochemical Journal. 2011, 434: 501-510. |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Tucker W.O. and Tanner J...A..., Inhibition of E3 Ubiquitin Ligase WWP1 with Selective DNA Aptamers, 3rd International Conference on Drug Discovery & Therapy, Dubai. UAE, 2011. |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Researcher : Tanner JA |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Identification, validation and characterization of the eukaryotic enzymes and regulators of inorganic polyphosphate metabolism |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Development of an Aptamer-Nanoparticle Based Rapid Diagnostic Test for Malaria |
| Investigator(s): | Tanner JA, Sun H |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis |
| Investigator(s): | Tanner JA, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Investigation of the interplay of polyphosphates and matrix vesicles in bone mineralization |
| Investigator(s): | Tanner JA, Li L |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Chan C.C.Y., Chan W.L., Tanner J.A., Chan D. and Cheah K.S.E., A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function. , The 44th Annual Meeting for the Japanese Society for Developmental Biologists, Okinawa, Japan, May 18-22, 2011. . 2011. |
| Chan W.L., Lau E., Chan D., Chu I., Cheah K.S.E. and Tanner J.A., Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes. , Human Proteome Organization Meeting HUPO2010, Sydney, Australia, September 24, 2010.. 2010. |
| Cheung Y.W. and Tanner J.A., Development of Nucleic Acid Aptamers against Plasmodium falciparum lactate dehydrogenase for improving the diagnosis of malaria, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Li L., Lui E.L.H. and Tanner J.A., Inorganic polyphosphate and bone - new roles for an ancient molecule, 无机多磷酸盐和骨－一种古老分子的新作用, University Lyon 1. 里昂第一大学, 2011. |
| Lin Y., Siu K.L., Tanner J.A. and Zheng B., Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein., 3rd International Conference on Drug Discovery & Therapy. . Dubai, UAE., 2011. |
| Lui E.L.H., Li L. and Tanner J.A., Inorganic Polyphosphate and its Impact on Osteoblast Function, Signaling and Gene Expression , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Shum K.T., Chan S.L.C. and Tanner J.A., Inhibiting sclerostin with a nucleic acid aptamer as a new approach to osteoporosis therapy, Johnson & Johnson Outstanding Graduate Thesis Award in Biotech One Day Symposium. 2011. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, PCT Patent Application No. PCT/CN2011/000879 filed on 23 May 2011. 2011. |
| Tanner J.A., Shum K.T. and Chan S.L.C., High-Affinity Nucleic Acid Aptamers against Sclerostin Protein, U.S. Non-Provisional Application No. 13/116,244 filed on 26 May 2011. 2011. |
| Tanner J.A., Nucleic Acids for Therapeutics and Diagnostics, University of Lyon, France. 2011. |
| Tucker W. and Tanner J.A., Inhibition of E3 Ubiquitin Ligase WWP1 with SELEX Generated DNA Aptamers , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tucker W.O. and Tanner J.A., DNA aptamer selection and cellular delivery for the inhibition of E3 ubiquitin ligase WWP1, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Yu Y., Chan D. and Tanner J.A., Nucleic acid aptamers against ADAMTS as a new therapeutic approach against degenerative disc disease, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Researcher : Tsang KY |
| Project Title: | The Role of Fibroblast Growth Factor 21 in ER Stress-Induced Skeletal Dysplasia |
| Investigator(s): | Tsang KY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | 2011 Gordon Research Conference on Cartilage Biology and Pathology Lineage reprogramming of hypertrophic chondrocytes in vivo |
| Investigator(s): | Tsang KY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 03/2011 |
| Completion Date: | 03/2011 |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., The Role of Autophagy in Determining Chondrocyte Cell Fates in Response to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Pei S.L.C., Chan W.C.W., Tsang K.Y., Mills A.A., Cheung M.C.H. and Chan D., Role of p53/p63 in Chondrocyte Re-differentiation upon Activation of ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M., Chan D. and Cheah K.S.E., Best Poster Prize: Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress. , Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D., Cheah K.S.E. and Zhang M., Mechanistic Insight into Chondrocyte Adaptation to ER Stress, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Researcher : Tsang SL |
| List of Research Outputs |
| Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199. |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Differential regulation of retinoic acid signaling in adult spinal cord neural progenitors., 9th Annual International Society of Stem Cell Research Meeting, Toronto, Canada, June 15-18, 2011. |
| Tam C.N., Cheng M.H., Tsang S.L., Sham M.H., Yam G.H.F. and Pang C.P., A Mutant gA-crystallin Leads to Cataractogenesis through the Unfolded Protein Response, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Researcher : Tsui MG |
| List of Research Outputs |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Researcher : Tsui MG |
| List of Research Outputs |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Researcher : Tsui YP |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan Conduits Seeded With Bone Marrow Stromal Cell-derived Schwann Cells Enhance Regeneration Of Rat Sciatic Nerve, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 65. 2010. |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Shum D.K.Y., Shea G.K.H., Tsui Y.P. and Chan Y.S., Directed differentiation of bone marrow stromal cells to fate commitment of Schwann cells for remyelination therapy. Annals Neuroscience, 17: 27. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies, Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: New perspective in CNS myelin repair, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 61-62. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards Myelin and Functional Recovery in the Injured CNS: Derivation of Oligodendrocyte Precursor Cells from Adult Bone Marrow Stromal Cells , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards functional recovery in the injured CNS: Generating oligodendrocyte precursors from bone marrow stromal cells for remyelination, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 63. [HK. March 5-6, 2011]. 2011. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards myelin repair in the CNS: Oligodendrocyte precursors derived from bone marrow stromal cells, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-e02. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Researcher : Tucker W |
| List of Research Outputs |
| Tucker W. and Tanner J.A., Inhibition of E3 Ubiquitin Ligase WWP1 with SELEX Generated DNA Aptamers , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Researcher : Tucker WO |
| List of Research Outputs |
| Shum K.T., Tucker W.O., Chan S.L.C., Leung C...M... and Tanner J...A..., New Approaches to Osteoporosis Therapy with Aptamer-Based Inhibitors, 6th Annual Meeting of the Oligonucleotide Therapeutics Society, Dana Point. California, 2010. |
| Tucker W.O. and Tanner J.A., DNA aptamer selection and cellular delivery for the inhibition of E3 ubiquitin ligase WWP1, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Tucker W.O. and Tanner J...A..., Inhibition of E3 Ubiquitin Ligase WWP1 with Selective DNA Aptamers, 3rd International Conference on Drug Discovery & Therapy, Dubai. UAE, 2011. |
| Researcher : Wang C |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Chan D. and Zhang M., Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo, XXIInd Meeting of the Federation of European Connective Tissue Societies, July 3 - 7, 2010, Davos, Switzerland. 2010. |
| Cheah K.S.E., Tan Z., Niu B., Tsang K.Y., Chan D., Zhang M., Ron D. and Wang C., Integration of Pathways Mediating Chondrocyte Adaptation to ER Stress in VIVO, Cold Spring Harbor Meeting on Mouse Development, Genetics & Genomics, New York, USA, Oct 26-30, 2010. New York. |
| Lie Y.S., Chan W.C.W., Tsang K.Y., Wang C., Tan Z., Cheah K.S.E. and Chan D., The role of autophagy in ER-stress induced chondrocyte re-differentiation, Gordon Conference: Cartilage Biology and Pathology, Ventura, U.S. March 6-11, 2011.. 2011. |
| Researcher : Wang J |
| List of Research Outputs |
| Li M.J., Sham P.C. and Wang J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, Bioinformatics. 2010, 26 (22): 2897-2899. |
| Researcher : Wang JJ |
| Project Title: | A systems biology's approach to understand calorie restriction and aging |
| Investigator(s): | Wang JJ, Huang J, Sham PC, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 09/2008 |
| Completion Date: | 08/2010 |
| Project Title: | Evolution and functional specialization of alternative promoters in humans |
| Investigator(s): | Wang JJ, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2009 |
| Project Title: | FastPval: a fast and memory efficient program to calculate very low p-values from empirical distribution |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2011 |
| Project Title: | A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus |
| Investigator(s): | Wang JJ, Tsao GSW |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Understanding genetic and epigenetic features of active promoters in human/mouse embryonic stem cells |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Li J., Sham P.C. and Wang J.J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, Bioinformatics. 2010, 26: 2897-2899. |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Combinatory Analysis of ChIP-seq/chip and Microarray Gene Expression Data, High Throughput Biology, Cold Spring Harbor Asia, Suzhou, China, Apr 19-23. 2011. |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, Hong Kong, Jun 11 . 2011. |
| Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor, Nucleic Acids Research. 2011, 39: W430-W436. |
| Wang J.J., Application of bioinformatics in stem cell study, Stem Cell & Regenerative Medicine Consortium (SCRMC), The University of Hong Kong, Hong Kong, China, Oct. 12. 2010. |
| Wang J.J., Co-evolution of Transcription Factors and Their Binding Sites, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. May. 20. 2011. |
| Wang J.J., Co-evolution of Transcription Factors and Their Binding Sites, TNLIST, Tsinghua University, Beijing, China. Mar. 23. 2011. |
| Wang J.J., Gene regulation, stem cells and cancer genomics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. Nov. 24. 2010. |
| Wang J.J., IEEE International Conference on Bioinformatics & Biomedicine 2010, 18-21 Dec., 2010, Hong Kong, China, PC Member, 2010. |
| Wang J.J., Prediction of transcription factor binding sites from protein sequence through protein-DNA co-evolution, CSH-Asia Conferences, Computational Biology. Cold Spring Harbor Asia, Suzhou, China. Oct. 1. 2010. |
| Wang W., Wei Z., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China. Jun 11 . 2011. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Yalamanchili H.K., Xiao Q.W. and Wang J.J., ProF: Neural Response Based Protein Function Prediction Algorithm, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Yang S., Agrawal K.R., Lam T.W., Sham P.C., Cheah K.S.E. and Wang J.J., A novel Profile Hidden Markov Model to predict microRNAs and their targets simultaneously. , 9th Annual International Conference on Computational Systems Bioinformatics, Stanford, United States. August 16-18. 2010. |
| Zhang G.L., Chen X.C., Chan L., Zhang M.X., Zhu B.H., Wang L.T., Zhu Z.Y., Zhang J., Zhou B.P. and Wang J.J., An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese, Sci. Rep.. 2011, 1: 20. |
| Researcher : Wang P |
| List of Research Outputs |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Combinatory Analysis of ChIP-seq/chip and Microarray Gene Expression Data, High Throughput Biology, Cold Spring Harbor Asia, Suzhou, China, Apr 19-23. 2011. |
| Qin J., Li M.J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, Hong Kong, Jun 11 . 2011. |
| Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor, Nucleic Acids Research. 2011, 39: W430-W436. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Researcher : Wang W |
| List of Research Outputs |
| Wang W., Wei Z., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China. Jun 11 . 2011. |
| Researcher : Wang X |
| List of Research Outputs |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Wang X., Cross talk between Hox genes and sonic hedgehog signalling during mouse hindbrain neurogenesis. 2010. |
| Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Wong E.Y.M., Wang X., Mak S.S., Sae-Pang J.J., Ling K.W., Fritzsch B. and Sham M.H., Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning, Developmental Biology. 2011, 352: 382-392. |
| Researcher : Wang X |
| List of Research Outputs |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Wang X., Cross talk between Hox genes and sonic hedgehog signalling during mouse hindbrain neurogenesis. 2010. |
| Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Wong E.Y.M., Wang X., Mak S.S., Sae-Pang J.J., Ling K.W., Fritzsch B. and Sham M.H., Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning, Developmental Biology. 2011, 352: 382-392. |
| Researcher : Wang X |
| List of Research Outputs |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Differential Requirement of Suppressor of Fused (Su (fu)) in Mammalian Hedgehog Signaling and Neural Development , 15th Research Postgraduate Symposium, HKU, December 1 & 2, 2010. |
| Hor H.H., Wang X., Hui C.C. and Sham M.H., Functions of Suppressor of fused (Su(fu)) in Mammalian Midbrain and Hindbrain Neurogenesis, The 2nd Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. |
| Wang X., Cross talk between Hox genes and sonic hedgehog signalling during mouse hindbrain neurogenesis. 2010. |
| Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Wong E.Y.M., Wang X., Mak S.S., Sae-Pang J.J., Ling K.W., Fritzsch B. and Sham M.H., Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning, Developmental Biology. 2011, 352: 382-392. |
| Researcher : Wang Y |
| Project Title: | Molecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2 |
| Investigator(s): | Wang Y, Xu A |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Elucidation of the molecular mechanisms underlying endothelial aging using integrated proteomic profiling approaches |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2009 |
| Completion Date: | 09/2010 |
| Project Title: | Discovery of novel inhibitors targeting lipocalin-2 for the treatment of obesity-related diabetes and cardiovascular diseases |
| Investigator(s): | Wang Y, Vanhoutte PMGR, Xu A |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2010 |
| Completion Date: | 05/2011 |
| Project Title: | Lipocalin-2 and myocardial remodeling in response to ischemia-reperfusion injury |
| Investigator(s): | Wang Y, Vanhoutte PMGR, Xu A |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2010 |
| Completion Date: | 06/2011 |
| Project Title: | Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | 10th International Symposium on Resistance Arteries SIRT1 and AMPK: the Seesaw Effect in Regulating Endothelial Senescence |
| Investigator(s): | Wang Y |
| Department: | Pharmacology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2011 |
| Completion Date: | 05/2011 |
| Project Title: | YY1 as a negative regulator of WNT1 gene expression: a role in mammary carcinogenesis |
| Investigator(s): | Wang Y, Xu A |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2011 |
| Researcher : Wang Y |
| List of Research Outputs |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Researcher : Wang Y |
| List of Research Outputs |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for humans, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Researcher : Wang Z |
| List of Research Outputs |
| Cui J., Wang Z., Cheng Q., Lin R., Zhang X.M., Leung P.S., Copeland N.G., Jenkins N.A., Yao K.M. and Huang J., Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. , Diabetes. 2011, 60 (1): 320-330. |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Researcher : Wong C.K.S. |
| List of Research Outputs |
| Shum K...T..., Lui E...L...H..., Wong C...K...S..., Yeung P..., Sam L..., Wang Y..., Watt R...M... and Tanner J...A..., Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2, Biochemistry. 2011, 50: 3261-3271. |
| Researcher : Wong EYM |
| List of Research Outputs |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wong E.Y.M., Wang X., Mak S.S., Sae-Pang J.J., Ling K.W., Fritzsch B. and Sham M.H., Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning, Developmental Biology. 2011, 352: 382-392. |
| Researcher : Wong HLX |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Jin G., Zhang F.J., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X.G., Mauch C. and Liu D., MT1-MMP inhibits Notch signaling to maintain normal B cell development. , EMBO Journal . 2011, 30(11): 2281-93. |
| Researcher : Wong NS |
| Project Title: | Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol |
| Investigator(s): | Wong NS, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2002 |
| Project Title: | Redox-mediated posttranscriptional regulation of CHOP expression: its implication in CHOP-mediated pathologies |
| Investigator(s): | Wong NS, Wang Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Completion Date: | 12/2010 |
| Project Title: | The role of protein phosphatase on the regulation of messenger RNA translation in response to cellular stress |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Completion Date: | 03/2011 |
| Project Title: | The role of glutathione metabolism in causing stress resistance of cancer cells |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Chan C.Y.T. and Wong N.S., Evidence for Physical Interaction between CHOP/Gadd153 mRNA and Specific Intracellular Proteins , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Chan Y.T.C. and Wong N.S., Evidence for direct and specific physical interaction between the stress-inducible CHOP mRNA and intracellular proteins, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2011. |
| Lam D. and Wong N.S., A Proposed Model for UPR-mediated Cellular Survival and Cell Death , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lam D. and Wong N.S., Intracellular ROS enhances the survival of cells under the conditions of ER stress, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium . 2011. |
| Lui T.W. and Wong N.S., The Role of the AU-rich Element in the mRNA of the Stress-inducible Protein CHOP/Gadd153, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Lui W.T. and Wong N.S., Functional significance of the 3’-UTR in the mRNA of the stress-inducible protein CHOP/Gadd153, HK Inter-University Biochemistry Postgraduate Symposium HK Inter-University Biochemistry Postgraduate Symposium 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium . 2011. |
| Wong N.S., Academic Editor, PlosONE. 2010. |
| Wong N.S., Faculty of Medicine Teaching Medal, 2011. |
| Researcher : Wong XHL |
| List of Research Outputs |
| Wong X.H.L. and Zhou Z., The Role of Farnesyltransferase Inhibitor in the Treatment of Hutchinson Gilford Progeria Syndrome, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Wu MH |
| List of Research Outputs |
| Cheung M.C.H., Wang Y., Wu M.H., Sham M.H., Chan D. and Cheah K.S.E., Generation of induced pluripotent stem (iPS) cells from bone forming cells., Gordon Conference on Cartilage Biology & Pathology, Ventura, USA, March 6-11, 2011. |
| Kwok C.S.T., Wu M.H., Cheung M.C.H., Herve A. and Nieto M.A., The Role of SoxE Transcription Factors in Melanoma Development , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E., Sham M.H. and Cheung M.C.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 15 th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Sham M.H., Generation of Induced Pluripotent Stem (iPS) Cells from Bone-forming Cells, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Wang Y., Cheung M.C.H., Wu M.H., Sham M.H. and Chan D., Generation of induced pluripotent stem (iPS) cells from bone forming cells, Cold Spring Harbor meeting on Molecular Switches and Genome Function in Stem Cells & Development, Suzhou, China, September 21- 25, 2010. |
| Researcher : Wu X |
| List of Research Outputs |
| Wu X., Osorio Da Silva L.A. and Zhou Z., Isthmin, a Novel Extracellular Regulator of Nodal Signaling , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Yalamanchili HK |
| List of Research Outputs |
| Yalamanchili H.K. and Xiao Q.W., NRProF: Neural Response Based Protein Function Prediction Algorithm, , Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11th, 2011. . 2011. |
| Yalamanchili H.K., Xiao Q.W. and Wang J.J., ProF: Neural Response Based Protein Function Prediction Algorithm, 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong SAR, China, June 11. 2011. |
| Researcher : Yang L |
| List of Research Outputs |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Researcher : Yang L |
| List of Research Outputs |
| Yang L., Hui W...S..., Chan W.C.W., Ng V.C.W., Yam T...H..., Leung H...C..., Huang J., Shum D.K.Y., Jie Q..., Cheung K...M...C..., Cheah K.S.E., Luo Z... and Chan D., A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas , Journal of Orthopaedic Research. 2010, 28(11): 1522-30. |
| Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Best Poster Prize: Lineage reprogramming of hypertrophic chondrocytes in vivo , Gordon Research Conference on Cartilage Biology & Pathology 2011. 2011. |
| Researcher : Yang M |
| List of Research Outputs |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Yu B., Yang M. and Huang J., Engineering Tumor Targeting Salmonella , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Yang S |
| List of Research Outputs |
| Yang S., Agrawal K.R., Lam T.W., Sham P.C., Cheah K.S.E. and Wang J.J., A novel Profile Hidden Markov Model to predict microRNAs and their targets simultaneously. , 9th Annual International Conference on Computational Systems Bioinformatics, Stanford, United States. August 16-18. 2010. |
| Researcher : Yao KM |
| Project Title: | Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2007 |
| Project Title: | Test of FoxM1 as an enhancer of induced pleuripotent stem cell production |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2011 |
| List of Research Outputs |
| Chan D.W., Liu V.W.S., Leung L.Y., Yao K.M., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells, In: Peter A Hall, Journal of Pathology. Pathological Society of Great Britain an, John Wiley & Sons, Ltd, 2011, 225: 525-34. |
| Cui J., Wang Z., Cheng Q., Lin R., Zhang X.M., Leung P.S., Copeland N.G., Jenkins N.A., Yao K.M. and Huang J., Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. , Diabetes. 2011, 60 (1): 320-330. |
| Ma R.Y., Tong T.H., Leung G.W.Y. and Yao K.M., Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1, In: Paul J. Higgins, Methods Mol Biol. Springer New York, Humana Press, 2010, 647: 113-123. |
| Shiu S.Y.W., Pang B., Tam C.W. and Yao K.M., Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Ga(s) and Ga(q) proteins, Journal of Pineal Research. 2010, 49: 301-311. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK. |
| Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2, a Novel Modulator in Hedgehog Signaling, 15th Research Postgraduate Symposium, The University of Hong Kong, Li Ka Shing Faculty of Medicine, December 2, 2010. . 2010. |
| Tsui M.G., Cheung M.C.H., Cheah K.S.E., Chan D. and Yao K.M., sPDZD2, a novel modulator in Hedgehog signaling, Japan Society of Developmental Biology 2011 at Okinawa, Japan, 2011. |
| Researcher : Yee FYA |
| List of Research Outputs |
| Yee F.Y.A., Melhado I.G., Grad S., Alini M., Cheah K.S.E., Chan D. and Cheung K.M.C., Cholesterol Biosynthesis is a Potential Pathway Involved in the Degeneration of the Annulus Fibrosus, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Yee F.Y.A., Melhado I.G., Cheah K.S.E., Cheung K.M.C. and Chan D., Transcriptome of the Human Intervertebral Disc in Health and Disease, World Forum for Spine Research - The Intervertebral Disc. July 5-8, 2010. Montreal, Canada . 2010. |
| Researcher : Yu B |
| List of Research Outputs |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Yu B., Yang M. and Huang J., Engineering Tumor Targeting Salmonella , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhang K., Yu B., Lou Y.S. and Zheng B., A Pilot Study of Oral Vaccine Development against H5N1 Avian Flu Using Salmonella asdA Mutant as Delivery System., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zheng S., Yu B., Hua Y., Yuen K.Y., Zheng B. and Huang J., Development of Live Recombinant Salmonella Oral Vaccine against Avian Influenza Viruses, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Yu B |
| List of Research Outputs |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Yu B., Yang M. and Huang J., Engineering Tumor Targeting Salmonella , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhang K., Yu B., Lou Y.S. and Zheng B., A Pilot Study of Oral Vaccine Development against H5N1 Avian Flu Using Salmonella asdA Mutant as Delivery System., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zheng S., Yu B., Hua Y., Yuen K.Y., Zheng B. and Huang J., Development of Live Recombinant Salmonella Oral Vaccine against Avian Influenza Viruses, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Yu Y |
| List of Research Outputs |
| Yu Y., Chan D. and Tanner J.A., Nucleic acid aptamers against ADAMTS as a new therapeutic approach against degenerative disc disease, Hong Kong Inter-University Biochemistry Postgraduate Symposium. 2011. |
| Researcher : Yuan QJ |
| List of Research Outputs |
| Yuan Q.J., Hu B., Chu T.H., Su H., Zhang W., So K.F., Lin Z. and Wu W., Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration, Nitric Oxide. 2010, 23: 258-263. |
| Researcher : Zhang L |
| List of Research Outputs |
| Chan W.C.W., Zhang L., Chan W.Y., Cheung K.M.C., Cheah K.S.E. and Chan D., Early onset intervertebral disc degeneration in a mouse model of Metaphysealchondrodysplasia type Schmid. , World Forum for Spine Research 2010—The Intervertebral Disc, Montreal, Canada, July 5 – 8, 2010. . 2010. |
| Researcher : Zhang M |
| List of Research Outputs |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Zhang M., A Sox10-GFP mutant mouse model for the study of abnormal enteric nervous system development in Hirschsprung Disease. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Beverly McKinnell Award , The 16th International Conference of the International Society of Differentiation. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 mutation affects enteric neural crest cell migration in a cell autonomous manner, Differentiation. 2010, 80: S23. |
| Researcher : Zhang M |
| List of Research Outputs |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Sham M.H., Zhang M., Leung C., Chu K.H., Chang C.N., Lui V.C.H. and Tam P.K.H., Sox10 mutation affects enteric neural crest cell migration, 44th Annual Meeting for the Japanese Society of Deveopmental Biologists, Okinawa, Japan, May 18-21, 2011. |
| Zhang M., A Sox10-GFP mutant mouse model for the study of abnormal enteric nervous system development in Hirschsprung Disease. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Beverly McKinnell Award , The 16th International Conference of the International Society of Differentiation. 2010. |
| Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 mutation affects enteric neural crest cell migration in a cell autonomous manner, Differentiation. 2010, 80: S23. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Zhang Y., Best Paper Presentation Award, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Outstanding Poster Presentation Award, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 and c-Myb in Beta-Amyloid Toxicity and Alzheimer’s Disease, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid Toxicity and Alzheimer’s Disease, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhang Y., Winner of Three Minute Thesis (3MTTM) Competition of HKU, 2011. 2011. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Zhang Y., Best Paper Presentation Award, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Outstanding Poster Presentation Award, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 and c-Myb in Beta-Amyloid Toxicity and Alzheimer’s Disease, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid Toxicity and Alzheimer’s Disease, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhang Y., Winner of Three Minute Thesis (3MTTM) Competition of HKU, 2011. 2011. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Zhang Y., Best Paper Presentation Award, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Outstanding Poster Presentation Award, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 and c-Myb in Beta-Amyloid Toxicity and Alzheimer’s Disease, Croucher Foundation - Alzheimer's Disease Conference, The University of Hong Kong, 2011. 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid Toxicity and Alzheimer’s Disease, Hong Kong Inter-University Biochemistry Postgraduate, June 11, 2011 . 2011. |
| Zhang Y., Zhang Y., Jin D. and Song Y., The Role of Pax6 in Beta-Amyloid-induced Neuronal Apoptosis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhang Y., Winner of Three Minute Thesis (3MTTM) Competition of HKU, 2011. 2011. |
| Researcher : Zheng S |
| List of Research Outputs |
| Zheng S., Yu B., Hua Y., Yuen K.Y., Zheng B. and Huang J., Development of Live Recombinant Salmonella Oral Vaccine against Avian Influenza Viruses, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Researcher : Zhou Z |
| Project Title: | Understanding the regulation of MT1-MMP activity in tumorigenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2006 |
| Project Title: | Lamin C in development and tumorigenesis |
| Investigator(s): | Zhou Z, Chan LC |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2007 |
| Completion Date: | 08/2010 |
| Project Title: | Screening anti-ageing substances in small chemical library using premature ageing animals |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2007 |
| Project Title: | Aging: epigenetic regulation, cell cycle checkpoint control and stem cell potency |
| Investigator(s): | Zhou Z, Cheah KSE, Chu IK, Smith DK, Lui VCH |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2008 |
| Completion Date: | 02/2011 |
| Project Title: | Regulation of FGFR signaling by MT1-MMP |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2008 |
| Project Title: | Epigenetics and Stem Cells Conference Stem cell decline contributes to accelerated aging |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2010 |
| Completion Date: | 08/2010 |
| Project Title: | Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Jin G., Zhang F., Chan K.M.J., Wong H.L.X., Liu B., Cheah K.S.E., Liu X., Mauch C., Liu D. and Zhou Z., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development., EMBO J. 2011, 30: 2281-93. |
| Lau E., Lam P.Y., Siu S.O., Kong P.W., Chan W.L., Zhou Z., Huang J., Lo C.S.C. and Chu I.K., Combinatorial Use of Offline SCX and Online RP–RP Liquid Chromatography for iTRAQ-based Quantitative Proteomics Applicationsw, Molecular BioSystems. 2011, 7: 1399-1408. |
| Sugiyama N., Varjosalo M., Meller P., Lohi J., Chan J.K.M., Zhou Z., Alitalo K., Taipale J., Keski-Oja J. and Lehti K., FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex., Proc Natl Acad Sci U S A. . 2010. |
| Wong X.H.L. and Zhou Z., The Role of Farnesyltransferase Inhibitor in the Treatment of Hutchinson Gilford Progeria Syndrome, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Wu X., Osorio Da Silva L.A. and Zhou Z., Isthmin, a Novel Extracellular Regulator of Nodal Signaling , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Zhou Z., Academic Editor, PLoS ONE. 2011. |
| Zhou Z., Stem Cells and Aging , Dasan Conference 2010 Translational Research in Aging Science KOREA 2010 Nov 3-5. 2010. |
| Researcher : Zhu G |
| List of Research Outputs |
| Chen M.H., Huang J., Deng H.K., Dong S., Deng W., Tsang S.L., Huen M.S.Y., Chen L., Zan T., Zhu G. and Guan X., Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. , BMC Cancer . 2011, 11: 199. |
| Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Necessary for Chondrocyte Cytokinesis, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |