DEPT OF PHARMACOLOGY & PHARMACY
| Researcher : Anand S |
| List of Research Outputs |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015. |
| He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300. |
| Researcher : BARETELLA OM |
| List of Research Outputs |
| BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Vascular responses in ageing: effects of obesity and/or constitutive activation of adenosine monophosphate-activated protein kinase (CA-AMPK), a TCM target, in endothelial cells, The 11th International Postgraduate Symposium on Chinese Medicine, August 14, 2015, Hong Kong. 2015. |
| Researcher : Bai B |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| Man W.C., Bai B. and Wang Y., Cloning and Characterization of Sirtuin3 (SIRT3) , Methods in Molecular Biology. 2016, 1436: 201-11. |
| Wang Y., Song E., Bai B. and Vanhoutte P.M.G.R., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes., Pharmacology & Therapeutics. 2016, 158: 91-100. |
| YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Researcher : CAI Y |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592. |
| YING F., Cai Y. and Tang E.H.C., Deliciency of Prostaglandin E2 Receptor Subtype 4 Causes Dysregulation of Cholesterol Homeeostasis in Mice, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Researcher : CHEN J |
| List of Research Outputs |
| CHEN J., The Metabolic Function of TIR-Domain-Containing Adapter-Inducing Interferon-b (TRIF) in Hepatocytes, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2015. |
| Woo W.H.C., CHEN J., LI J., YIU J.H.C. and Xu A., Metabolic Function of Toll like Receptor mediated by TRIF, In: Federation of American Societies for Experimental Biology, FASEB Summer Research Conference 2015, Nutritional Immunology: Role in Health and Disease. 2015. |
| Researcher : CHENG KF |
| List of Research Outputs |
| CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015. |
| Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18. |
| SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54. |
| Researcher : CHEONG LY |
| List of Research Outputs |
| SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015. |
| Researcher : CHEUNG C |
| List of Research Outputs |
| Li W.S.R., Yang C., Shan L., Zhang Z., Wang Y., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., CHEUNG C. and Leung G.P.H., Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries, European Journal of Pharmacology. 2015, 761: 153-160. |
| Researcher : CHOW YT |
| List of Research Outputs |
| CHOW Y.T. and Lam J.K.W., Dry powder formulation of plasmid DNA and siRNA for inhalation, Current Pharmaceutical Design. 2015, 21: 3854-3866. |
| CHOW Y.T., Formulation of Inhalable Dry Powder of Naked siRNA by Spray Drying, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2016. 2015. |
| Kwok P.C.L., Grabarek A., CHOW Y.T., Lan Y., Li J.C.W., Casettari L., Mason A.J. and Lam J.K.W., Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis, International Journal of Pharmaceutics. 2015, 491: 367-374. |
| Lam J.K.W., CHOW Y.T., ZHANG Y. and Leung S.W.S., siRNA Versus miRNA as Therapeutics for Gene Silencing, Molecular Therapy—Nucleic Acids. 2015, 4: e252. |
| MAN K.W.D., CHOW Y.T., Casettari L., Gonzalez-Juarrero M. and Lam J.K.W., Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis, Advanced Drug Delivery Reviews. 2016, 102: 21-32. |
| Researcher : CHUI SLC |
| List of Research Outputs |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Researcher : Cai Y |
| Project Title: | Experimental Biology 2016; Inhibition Of COX-2/PGE2/EP4 Signaling Protects Against Post-hypoxic Apoptosis In H9C2 Cardiomyocytes |
| Investigator(s): | Cai Y |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592. |
| YING F., Cai Y. and Tang E.H.C., Deliciency of Prostaglandin E2 Receptor Subtype 4 Causes Dysregulation of Cholesterol Homeeostasis in Mice, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Researcher : Chan EW |
| Project Title: | Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial. |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2014 |
| Project Title: | Young adult patient experiences in clinical management of ADHD in Hong Kong |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Janssen Pharmaceutica - General Award |
| Start Date: | 01/2014 |
| Project Title: | Mother’s preferences and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment in Hong Kong |
| Investigator(s): | Chan EW, McGhee S, Wong CKH, Ip DKM, Chau J, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2014 |
| Project Title: | Pharmacoepidemiology of oral anticoagulation agents – a comparison of dabigatran etexilate, warfarin and dual-antiplatelet therapy in patients with atrial fibrillation |
| Investigator(s): | Chan EW, Cheung BMY, Leung WK, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | Cardiovascular outcomes associated with use of clarithromycin |
| Investigator(s): | Chan EW, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Completion Date: | 05/2016 |
| Project Title: | 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Suboptimal management of patients with non-valvular atrial fibrillation: real-world clinical setting |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department ??a multicentre randomised clinical trial. |
| Investigator(s): | Chan EW, Leung LP |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 06/2016 |
| List of Research Outputs |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Chan E.W., Incentive award for successful grant applicants for 2014/15 RGC/GRF funding., Faculty of Medicine, The University of Hong Kong. 2015. |
| Chan E.W., Tang C., LAO S., Leung L.P., Tsui S.H., Ho H.F., Wong G., Kong D.C.M., Knott J.C. and Wong I.C.K., Management of acute agitation in Hong Kong and comparisons with Australasia, Emerg Med Australas. 2015, 27(6): 542-548. |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272. |
| Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272. |
| Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016. |
| Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73. |
| Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015. |
| Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| Garriga M., Pacchiarotti I., Kasper S., Zeller S.L., Allen M.H., Vázquez G., Baldacara L., San L., McAllister-Williams H., Fountoulakis K., Courtet P., Naber D., Chan E.W., Fagiolini A., Möller H.J., Grunze H., Llorca P.M., Jaffe R.L., Yatham L.L., Mazzei D.H., Passamar M., Messer T., Bernardo M. and Vieta E., Assessment and management of agitation in Psychiatry: Expert consensus., World J. Biol. Psychiatry. 2016, 17(2): 86-128. |
| HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015. |
| He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| LAU C.Y., Chan E.W. and Wong I.C.K., Efficacy and safety of dabigatran versus warfarin in patients with non-valvular atrial fibrillation., The Queen Elizabeth II Conference Centre, London, UK. 2015. |
| Leung A.Y.M., Lau H.F., Chau P.H. and Chan E.W., Chinese Health Literacy Scale for Diabetes – Multiple-choice version (CHLSD-MC): A Validation Study, Journal of Clinical Nursing. John Wiley & Sons Ltd., 2015, 24(17-18): 2679-2682. |
| Leung B., Jokanovic N., Tan E.C., Jamsen K.M., Emery T., Robson L., Manias E., Pitkälä K.H., Chan E.W. and Bell J.S., Prescribed Doses of Opioids in Long-Term Care Facilities., J Am Med Dir Assoc.. 2015, 16(12): 1100-1102. |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Li X., Tse V.C., Au-Doung L.W., Wong I.C.K. and Chan E.W., The impact of ischaemic stroke on atrial fibrillation-related healthcare cost: a systematic review., Europace. 2016, pii: euw093. |
| Man K.C.K., Chan E.W., Coghill D., Ip P., Simonoff E., Chan P., LAU C.Y. and Wong I.C.K., Prenatal Antidepressant Exposure and the Risk of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder, 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 2015. |
| Roughead E.E., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Nguyen T.A., Ooba N., Park B.J., Sato T., Shin J.Y., Wang T., Griffiths J., Wong I.C.K., Kao Yang Y.H. and Pratt N.L., Variation in association between thiazolidinediones and heart failure across ethnic groups: Retrospective analysis of large healthcare claims databases in six countries, Drug Safety. 2015, 38 (9): 823-831. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Chan E.W., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November (oral).. 2015. |
| Taylor D.M.C.D., Yap C., Knott J.C., Taylor S., Phillips G.A., Karro J., Chan E.W., Kong D.C.M. and Castle D.J., Intravenous Midazolam-Droperidol (combination), Droperidol (only) or Olanzapine (only) for the acutely agitated patient: A multi-centred, randomised, double-blind, triple-dummy, clinical trial., 16th ICEM, Cape Town, South Africa, 18-21st April.. 2016. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Yap Y.L., Taylor D.M.C.D., Knott J.C., Taylor S.E., Phillips G.A., Karro J., Chan E.W., Kong D.C.M. and Castle D.J., Intravenous Midazolam-Droperidol (combination), Droperidol or Olanzapine for Methamphetamine-related Agitation in the Emergency Department., 169th APA Annual Meeting, Atlanta, Georgia, United States, 14-18th May (Poster).. 2016. |
| Researcher : Chan HK |
| List of Research Outputs |
| Wong J., Kwok P.C.L., Niemelä V., Heng D., Crapper J. and Chan H.K., Bipolar electrostatic charge and mass distributions of powder aerosols – Effects of inhaler design and inhaler material, Journal of Aerosol Science. 2016, 95: 104-117. |
| Wong J., Lin Y.-.W., Kwok P.C.L., Niemelä V., Crapper J. and Chan H.K., Measuring bipolar charge and mass distributions of powder aerosols by a novel tool (BOLAR), Molecular Pharmaceutics. 2015, 12: 3433-3440. |
| Researcher : Chan WLP |
| List of Research Outputs |
| Chan W.L.P., Faculty Teaching Medal, LKS Faculty of Medicine, University of Hong Kong. 2016. |
| Chan W.L.P., IT Enhanced Pharmacy Education - Two Sides of the Coin, 7th Asian Association of School of Pharmacy Conference. 2015. |
| Chan W.L.P., Improving Medication Safety and Diabetes Management in Hong Kong - A Multi-disciplinary Approach, 17th Diabetes and Cardiovascular Risk Factors East Meets West Symposium. 2015. |
| Researcher : Chan WYE |
| Project Title: | Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial. |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2014 |
| Project Title: | Young adult patient experiences in clinical management of ADHD in Hong Kong |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Janssen Pharmaceutica - General Award |
| Start Date: | 01/2014 |
| Project Title: | Mother’s preferences and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment in Hong Kong |
| Investigator(s): | Chan EW, McGhee S, Wong CKH, Ip DKM, Chau J, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2014 |
| Project Title: | Pharmacoepidemiology of oral anticoagulation agents – a comparison of dabigatran etexilate, warfarin and dual-antiplatelet therapy in patients with atrial fibrillation |
| Investigator(s): | Chan EW, Cheung BMY, Leung WK, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | Cardiovascular outcomes associated with use of clarithromycin |
| Investigator(s): | Chan EW, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Completion Date: | 05/2016 |
| Project Title: | 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Suboptimal management of patients with non-valvular atrial fibrillation: real-world clinical setting |
| Investigator(s): | Chan EW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department ??a multicentre randomised clinical trial. |
| Investigator(s): | Chan EW, Leung LP |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Researcher : Cheung CL |
| Project Title: | Epidemiological study of serious adverse drug reactions in Hong Kong |
| Investigator(s): | Cheung CL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Genetics and genomics of anti-thyroid drug induced agranulocytosis |
| Investigator(s): | Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study |
| Investigator(s): | Cheung CL, Tan KCB, Kung AWC, Cheung BMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2015 |
| Project Title: | Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study |
| Investigator(s): | Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | American Society of Bone and Mineral Research (ASBMR) 2015 Annual Meeting; Evaluation of cutpoints for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004 |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Precision Medicine of Osteoporosis Medication in Chinese (PreMOMiC): A retrospective and prospective pharmacogenomic study of denosumab |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed only in the presence of peripheral vascular disease., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17. |
| Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed when peripheral artery disease is present, Journal of Diabetes and its Complications. 2015, 30: 306-11. |
| Cheung C.L., Editorial Board, Osteoporosis and Sarcopenia. 2015. |
| Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of Cutpoints for Low Lean Mass and Slow Gait Speed in Predicting Death in the National Health and Nutrition Examination Survey 1999-2004, J Gerontol A Biol Sci Med Sci.. 2016, 71: 90-5. |
| Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17. |
| Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61. |
| Cheung C.L., Potential Application of Genetic Testing to the Diagnosis of Osteoporosis, The 4th Scientific Meeting of the Asian Federation of Osteoporosis Societies cum the 16th Regional Osteoporosis Conference. 2015. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18. |
| Cheung C.L. and Cheung B.M.Y., Relationship between serum beta-2-microglobulin and cardiovascular risk factors., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18. |
| Cheung C.L. and Cheung B.M.Y., Relationship between serum beta-2-microglobulin and cardiovascular risk factors., Presented at the European Society of Cardiology Congress 2015, London. 2015. |
| Cheung C.L., Vitamin D in Endocrine diseases, The 7th AASD Scientific Meeting and Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction (AASD 2015). 2015. |
| Dalgaard K., Landgraf K., Heyne S., Lempradl A., Loninotto J., Gossens K., Ruf M., Orthofer M., Strogantsev R., Selvaraj M., Lu T.T., Casas E., Teperino R., Surani M.A., Zvetkova I., Rimmington D., Tung Y.C., Lam B., Larder R., Yeo G.S., O'Rahilly S., Vavouri T., Whitelaw E., Penninger J.M., Jenuwein T., Cheung C.L., Ferguson-Smith A.C., Coll A.P., Korner A. and Pospisilik J.A., Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity, Cell. 2016, 164: 353-364. |
| HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in Prescriptions for Osteoporosis and Reduction in Hip Fracture Incidence in Hong Kong 2005-2014., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 25. |
| HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in prescriptions for osteoporosis and reduction in hip fracture incidence in Hong Kong 2005-2014., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015. |
| Han Y., Leung Y.H., Cheung B.M.Y. and Cheung C.L., Relationship of serum vitamin D status and risk of stroke., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016. |
| Leung Y.H., Cheung B.M.Y., Kung A.W.C., Tan K.C.B. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 35. |
| Leung Y.H., Cheung B.M.Y. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern Chinese., Presented at the ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern chinese, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2016. 2015. |
| SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54. |
| TSOI M.F., Cheung C.L., Cheung T.T. and Cheung B.M.Y., Continual Decrease in Blood Lead Level in Americans: United States National Health Nutrition and Examination Survey 1999-2014, The American Journal of Medicine. 2016. |
| TSOI M.F., Cheung A.J., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Decrease in blood lead level in the United States Population: United States National Health Nutrition and Examination Survey (NHANES) 1999-2014., Presented at the11th International Symposium on Healthy Aging 2016, Hong Kong. 2016. |
| TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204. |
| Researcher : Cho CH |
| Project Title: | Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats |
| Investigator(s): | Cho CH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2004 |
| Project Title: | Adrenaline and its receptor activation on colon cancer growth |
| Investigator(s): | Cho CH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2006 |
| Researcher : Chui SLC |
| List of Research Outputs |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Researcher : Chung CK |
| List of Research Outputs |
| CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015. |
| Researcher : DETREMMERIE CMS |
| List of Research Outputs |
| DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Biased Activation of Soluble Guanylyl Cyclase Can Cause Contraction of Isolated Arteries, Experimental Biology 2016, San Diego, California, U.S.A. FASEB J, 2016, 30. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Concentration-dependent vascular effects of divalent manganese, The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine & 10th Across the Strait Scientific Conference on Cardiovascular Science, 21 November 2015, Hong Kong. Journal of Hong Kong College of Cardiology, 2015, 23: 92. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions of isolated arteries to thymoquinone require biased activation of soluble guanylyl cyclase with resulting production of cyclic IMP, Pharmacology 2015, 15-17 December 2015, London, United Kingdom. 2015. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Vascular Effects of Divalent Manganese as a Cofactor of Soluble Guanylyl Cyclase, Experimental Biology 2016, San Diego, California, U.S.A.. FASEB J, 2016, 30. |
| Researcher : Deng H |
| Project Title: | Does adiponectin facilitate the detoxification of oxidised low density lipoprotein in adipose tissue through clusterin (ApoJ)? |
| Investigator(s): | Deng H, Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 02/2016 |
| List of Research Outputs |
| Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced clusterin (ApoJ) content of low density lipoproteins contribute to endothelial dysfunction in adiponectin-deficient mice, 83rd European Atherosclerosis Society Congress. ELSEVIER, 2015, 16(S2). |
| Researcher : Dufay S |
| Project Title: | Quantitation of Dexmedetomidine in plasma for pharmacokinetic study after intranasal administration in healthy volunteers |
| Investigator(s): | Dufay S, Irwin MG, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2013 |
| Researcher : FENG T |
| List of Research Outputs |
| Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015. |
| Researcher : GUO Y |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| GUO Y., WANG L., Huang M., LEE I., Xu A. and Wang Y., Overexpression of SIRT1 in Adipose tissue Induces Clusterin-mediated Beneficial Metabolic Effects on Adiponectin Knockout Mice during Obesity, 76th Scientific sessions New Orleans, LA, June 10-14, 2016. |
| Guo Y., Xu A. and Wang Y., SIRT1 in endothelial cells as a novel target for the prevention of early vascular ageing, Journal of Cardiovascular Pharmacology. 2016, 67: 465-73. |
| Researcher : Guo Y |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| GUO Y., WANG L., Huang M., LEE I., Xu A. and Wang Y., Overexpression of SIRT1 in Adipose tissue Induces Clusterin-mediated Beneficial Metabolic Effects on Adiponectin Knockout Mice during Obesity, 76th Scientific sessions New Orleans, LA, June 10-14, 2016. |
| Guo Y., Xu A. and Wang Y., SIRT1 in endothelial cells as a novel target for the prevention of early vascular ageing, Journal of Cardiovascular Pharmacology. 2016, 67: 465-73. |
| Researcher : HE Y |
| List of Research Outputs |
| HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015. |
| Researcher : He YH |
| List of Research Outputs |
| He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300. |
| Researcher : Ho KC |
| List of Research Outputs |
| SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54. |
| Researcher : Huang B |
| List of Research Outputs |
| Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced clusterin (ApoJ) content of low density lipoproteins contribute to endothelial dysfunction in adiponectin-deficient mice, 83rd European Atherosclerosis Society Congress. ELSEVIER, 2015, 16(S2). |
| Researcher : Huang M |
| List of Research Outputs |
| GUO Y., WANG L., Huang M., LEE I., Xu A. and Wang Y., Overexpression of SIRT1 in Adipose tissue Induces Clusterin-mediated Beneficial Metabolic Effects on Adiponectin Knockout Mice during Obesity, 76th Scientific sessions New Orleans, LA, June 10-14, 2016. |
| Researcher : Kwok PCL |
| Project Title: | Inhalable dry powder aerosols for influenza prevention or treatment |
| Investigator(s): | Kwok PCL, Yen H, Peiris JSM |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2012 |
| Project Title: | Inhalable macromolecule dry powder for asthma treatment in children |
| Investigator(s): | Kwok PCL, Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 01/2014 |
| Project Title: | Inhalable antimicrobial peptide dry powder for tuberculosis treatment |
| Investigator(s): | Kwok PCL, Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Project Title: | Aerosol performance of generic pharmaceutical combination inhalers |
| Investigator(s): | Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Project Title: | Dexmedetomidine buccal spray solution for premedication in children |
| Investigator(s): | Kwok PCL, Dufay S, Yuen VMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 05/2015 |
| Project Title: | Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery |
| Investigator(s): | Kwok PCL, Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | 3rd Annual International Conference on Pharmaceutical Sciences; Inhaled lidocaine powder for oropharyngeal anaesthesia |
| Investigator(s): | Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| Project Title: | Transport of dexmedetomidine across the nasal mucosa |
| Investigator(s): | Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Kwok P.C.L., Anatomy and physiology of the respiratory tract, Inhalation Asia Autumn School 2015, Shenyang Pharmaceutical University, Shenyang, China. 2015. |
| Kwok P.C.L., Electrostatics of pharmaceutical aerosols II, Inhalation Asia Autumn School 2015, Shenyang Pharmaceutical University, Shenyang, China. 2015. |
| Kwok P.C.L., Electrostatics of pharmaceutical aerosols I, Inhalation Asia Autumn School 2015, Shenyang Pharmaceutical University, Shenyang, China. 2015. |
| Kwok P.C.L., Electrostatics of pharmaceutical aerosols for pulmonary delivery, Current Pharmaceutical Design. 2015, 21: 3945-3954. |
| Kwok P.C.L., Grabarek A., CHOW Y.T., Lan Y., Li J.C.W., Casettari L., Mason A.J. and Lam J.K.W., Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis, International Journal of Pharmaceutics. 2015, 491: 367-374. |
| Kwok P.C.L., Respiratory drug delivery and aerosols as medicines, Inhalation Asia Autumn School 2015, Shenyang Pharmaceutical University, Shenyang, China. 2015. |
| Kwok P.C.L., Respiratory drug delivery: The fundamentals, Inhalation 101 Workshop, Inhalation Asia 2015, Shenyang, China. 2015. |
| Wong J., Kwok P.C.L., Niemelä V., Heng D., Crapper J. and Chan H.K., Bipolar electrostatic charge and mass distributions of powder aerosols – Effects of inhaler design and inhaler material, Journal of Aerosol Science. 2016, 95: 104-117. |
| Wong J., Lin Y.-.W., Kwok P.C.L., Niemelä V., Crapper J. and Chan H.K., Measuring bipolar charge and mass distributions of powder aerosols by a novel tool (BOLAR), Molecular Pharmaceutics. 2015, 12: 3433-3440. |
| Researcher : LAO S |
| List of Research Outputs |
| Chan E.W., Tang C., LAO S., Leung L.P., Tsui S.H., Ho H.F., Wong G., Kong D.C.M., Knott J.C. and Wong I.C.K., Management of acute agitation in Hong Kong and comparisons with Australasia, Emerg Med Australas. 2015, 27(6): 542-548. |
| LAO S., Antipsychotic Prescription Trend in Hong Kong from 2004 to 2014, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2015. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| Researcher : LAU CY |
| List of Research Outputs |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| LAU C.Y., Chan E.W. and Wong I.C.K., Efficacy and safety of dabigatran versus warfarin in patients with non-valvular atrial fibrillation., The Queen Elizabeth II Conference Centre, London, UK. 2015. |
| LAU C.Y., Murry M.L., El-Turki A., Saxena S., Ladhani S., Long P., Sharland M., Wong I.C.K. and Hsia Y., Impact of pneumococcal conjugate vaccines on childhood otitis media in the United Kingdom, Vaccine. 2015. |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Man K.C.K., Chan E.W., Coghill D., Ip P., Simonoff E., Chan P., LAU C.Y. and Wong I.C.K., Prenatal Antidepressant Exposure and the Risk of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder, 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 2015. |
| Researcher : LIU Q |
| List of Research Outputs |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Researcher : Lam JKW |
| Project Title: | The use of N-acetyl cysteine grafted chitosan as mucosal adjuvant in intranasal formulation of DNA vaccine |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2013 |
| Completion Date: | 03/2016 |
| Project Title: | Intravaginal delivery of antiretroviral drug using polymeric micelle gel formulation to prevent HIV infection |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Completion Date: | 03/2016 |
| Project Title: | Intranasal Delivery of DNA Vaccine using Oligochitosan/PLGA Nanoparticles |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Completion Date: | 08/2016 |
| Project Title: | Development of a highly effective, pH responsive peptide, siRNA delivery system to the respiratory tract to combat influenza virus infections |
| Investigator(s): | Lam JKW, Poon LML |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Formulation of carrier-free inhalable siRNA powders for the treatment of respiratory diseases |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Project Title: | Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier |
| Investigator(s): | Lam JKW, Chen Z, Kwok PCL, Lan Y, Chu YJ |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Inhalable dry powder formulation of naked siRNA using spray-drying and spray freeze-drying technologies for the treatment of respiratory infections |
| Investigator(s): | Lam JKW, Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | Role of pulmonary surfactants on siRNA delivery to the airway |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| List of Research Outputs |
| CHOW Y.T. and Lam J.K.W., Dry powder formulation of plasmid DNA and siRNA for inhalation, Current Pharmaceutical Design. 2015, 21: 3854-3866. |
| Kwok P.C.L., Grabarek A., CHOW Y.T., Lan Y., Li J.C.W., Casettari L., Mason A.J. and Lam J.K.W., Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis, International Journal of Pharmaceutics. 2015, 491: 367-374. |
| Lam J.K.W., Antimicrobial peptides against Mycobacterium tuberculosis, 3rd International TB-Meeting, Inhaled therapeutics for tuberculosis and other infectious diseases, Parma, Italy. 2015. |
| Lam J.K.W., CHOW Y.T., ZHANG Y. and Leung S.W.S., siRNA Versus miRNA as Therapeutics for Gene Silencing, Molecular Therapy—Nucleic Acids. 2015, 4: e252. |
| MAN K.W.D., CHOW Y.T., Casettari L., Gonzalez-Juarrero M. and Lam J.K.W., Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis, Advanced Drug Delivery Reviews. 2016, 102: 21-32. |
| Martarelli D., Casettari L., Shalaby K.S., Soliman M.E., Cespi M., Bonacucina G., Fagioli L., Perinelli D.R., Lam J.K.W. and Palmieri G.F., Optimization of melatonin dissolution from extended release matrices using artificial neural networking, Current Drug Delivery. 2016, 13: 565-573. |
| Perinelli D.R., Casettari L., Cespi M., Fini F., MAN K.W.D., Giorgioni G., Canala S., Lam J.K.W., Bonacucina G. and Palmieri G.F., Chemical–physical properties and cytotoxicity of N-decanoyl amino acid-based surfactants: Effect of polar heads, Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016, 492: 38-46. |
| Perinelli D.R., Cespi M., Bonacucina G., Naylor A., Whitakier M., Lam J.K.W., Howdle S.M., Casettari L. and Palmieri G.F., PEGylated Biodegradable Polyesters for PGSS Microparticles Formulation: Processability, Physical and Release Properties, Current Drug Delivery. 2016, 13: 673-681. |
| Rajabnezhad S., Casettari L., Lam J.K.W., Nomani A., Torkamani M.R., Palmieri G.F., Rajabnejad M.R. and Darbandi M.A., Pulmonary delivery of rifampicin microspheres using lower generation polyamidoamine dendrimers as a carrier, Powder Technology. 2016, 291: 366-374. |
| WANG S., Tong Y., Ng T.B., Lao L., Lam J.K.W., Zhang Y., Zhang Z. and Sze C.W.S., Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms, Chinese Medicine. 2015, 10: 19. |
| WONG K.L., Lai Y.M., Li K.W., Lee C.K.F., Ng T.B., CHEUNG H.P., Zhang Y., Lao L., Wong R.N.S., Shaw P.C., Wong J.H., Zhang Z., Lam J.K.W., Ye W. and Sze C.W.S., A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome, Scientific Reports. 2015, 5: 10179. |
| XU Y. and Lam J.K.W., Development of pH responsive cationic amphipathic LAH4-L1 peptide as a novel DNA vaccine delivery system, The 2015 Vaccine Summit, 13-15 Oct 2015, London, UK. 2015. |
| Researcher : Lam MPS |
| List of Research Outputs |
| Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Prevalence of Potentially Inappropriate Prescribing Among Hong Kong Older Adults: A Comparison of the Beers 2003, Beers 2012, and Screening Tool of Older Person's Prescriptions and Screening Tool to Alert doctors to Right Treatment Criteria, Journal of the American Geriatrics Society . 2015, 63: 1471-2. |
| Lam M.P.S., Teaching and learning methodology to advance pharmacy education in Hong Kong, 7th Asian Association of Schools of Pharmacy (AASP) Conference, Taipei. 2015. |
| Lam M.P.S., Wong I.C.K. and Cheung B.M.Y., Using the prevalence of potentially inappropriate prescribing in Hong Kong as an example to illustrate the importance of content validation, 11th International Symposium on Healthy Aging, Hong Kong. 2016. |
| Researcher : Lan Y |
| List of Research Outputs |
| Kwok P.C.L., Grabarek A., CHOW Y.T., Lan Y., Li J.C.W., Casettari L., Mason A.J. and Lam J.K.W., Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis, International Journal of Pharmaceutics. 2015, 491: 367-374. |
| Researcher : Lau CY |
| List of Research Outputs |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| LAU C.Y., Chan E.W. and Wong I.C.K., Efficacy and safety of dabigatran versus warfarin in patients with non-valvular atrial fibrillation., The Queen Elizabeth II Conference Centre, London, UK. 2015. |
| LAU C.Y., Murry M.L., El-Turki A., Saxena S., Ladhani S., Long P., Sharland M., Wong I.C.K. and Hsia Y., Impact of pneumococcal conjugate vaccines on childhood otitis media in the United Kingdom, Vaccine. 2015. |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Man K.C.K., Chan E.W., Coghill D., Ip P., Simonoff E., Chan P., LAU C.Y. and Wong I.C.K., Prenatal Antidepressant Exposure and the Risk of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder, 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 2015. |
| Researcher : Leung GPH |
| Project Title: | Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4) |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2005 |
| Project Title: | Vascular protective effect of narirutin |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Effects of novel Rho kinase inhibitors on human nucleoside transporters |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Protective effects of Pleurotus ostreatus (Oyster mushroom) and ergothioneine against doxorubicin-induced cardiotoxicity |
| Investigator(s): | Leung GPH, Xia Z, Zhang Y, So TH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | Role of equilibrative nucleoside transporter-2 in the development of neonatal heart cells |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Cui G.Q., Shan L.C., Chu I.K., LI G.H., Leung G.P.H., Wang Y.Q., Kwan Y.W., Chan S.W., Hoi P.M. and Lee M.Y., Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents, RSC Adv.. 2015, 5: 74605-74610. |
| Li S., Dang Y., Zhou X., Huang B., Zhang Z., Kwan Y.W., Chan S.W., Leung G.P.H., Lee S.M. and Hoi M.P., Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway, Scientific Reports . 2015, 5: 16815. |
| Li W.S.R., Yang C., Shan L., Zhang Z., Wang Y., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., CHEUNG C. and Leung G.P.H., Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries, European Journal of Pharmacology. 2015, 761: 153-160. |
| Poon C.C., Li W.S.R., Seto S.W., Kong S.K., Ho H.P., Hoi M.P., Lee S.M., Ngai S.M., Chan S.W., Leung G.P.H. and Kwan Y.W., In vitro vitamin K2 and 1α,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice, European Journal of Pharmacology . 2015, 767: 30-40. |
| TANG C.T.P. and Leung G.P.H., Characterization of 4-([4-(2-fluorophenyl) piperazin-1-yl] methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) as a Novel ENT2-Selective Inhibitor, Pharmacology 2015, London, United Kingdom,.15-17 December, 2015. |
| Researcher : Leung SWS |
| Project Title: | Therapeutic potential of herbal flavonoids in the management of chronic obstructive pulmonary disease |
| Investigator(s): | Leung SWS, Mak JCW, Man RYK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Regulation of endothelium-derived contracting factor release by nitric oxide |
| Investigator(s): | Leung SWS, Man RYK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 11/2015 |
| Project Title: | Vasoconstrictor signals in hypoxia: role of soluble guanylyl cyclase |
| Investigator(s): | Leung SWS, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Effect s of different components of the Chinese medicine, Astragali Radix (Huangqi), on angiogenic and inflammatory responses of endothelial cells to atherogenic lipoproteins |
| Investigator(s): | Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Project Title: | Endothelium‐Dependent Hyperpolarizations in Health and Disease (EDH2015); Endothelium-dependent hyperpolarization: age, gender and high blood pressure, does it matter? |
| Investigator(s): | Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2015 |
| Completion Date: | 09/2015 |
| Project Title: | Vascular effect of thymoquinone, a natural product used in humans as a folk medicine |
| Investigator(s): | Leung SWS, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Biased Activation of Soluble Guanylyl Cyclase Can Cause Contraction of Isolated Arteries, Experimental Biology 2016, San Diego, California, U.S.A. FASEB J, 2016, 30. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Concentration-dependent vascular effects of divalent manganese, The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine & 10th Across the Strait Scientific Conference on Cardiovascular Science, 21 November 2015, Hong Kong. Journal of Hong Kong College of Cardiology, 2015, 23: 92. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions of isolated arteries to thymoquinone require biased activation of soluble guanylyl cyclase with resulting production of cyclic IMP, Pharmacology 2015, 15-17 December 2015, London, United Kingdom. 2015. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Vascular Effects of Divalent Manganese as a Cofactor of Soluble Guanylyl Cyclase, Experimental Biology 2016, San Diego, California, U.S.A.. FASEB J, 2016, 30. |
| Lam J.K.W., CHOW Y.T., ZHANG Y. and Leung S.W.S., siRNA Versus miRNA as Therapeutics for Gene Silencing, Molecular Therapy—Nucleic Acids. 2015, 4: e252. |
| Leung S.W.S. and Vanhoutte P.M.G.R., Endothelium-dependent hyperpolarization: age, gender and high blood pressure , Endothelium-Dependent Hyperpolarizations in Health and Disease, 14 -17 September, 2015, Nyborg, Funen, Denmark . Acta Physiologica, 2015, 215 (Suppl. 703): 11. |
| Mokhtar S.S., Vanhoutte P.M.G.R., Leung S.W.S., Yusof M.I., Wan Sulaiman W.A., Suppian R. and Rasool A.H., Endothelium dependent hyperpolarization-type relaxation compensates for attenuated nitric oxide-mediated responses in subcutaneous arteries of diabetic patients., Nitric Oxide. 2016, 53: 35-44. |
| Mokhtar S.S., Vanhoutte P.M.G.R., Leung S.W.S., Suppian R., Yusof M.I. and Rasool A.H., Reduced nitric oxide-mediated relaxation and endothelial nitric oxide synthase expression in the tail arteries of streptozotocin-induced diabetic rats., Eur J Pharmacol. 2016, 773: 78-84. |
| Vanhoutte P.M.G.R., Zhao Y., Xu A. and Leung S.W.S., Thirty Years of Saying NO, Circulation Research. 2016, 119: 375-396. |
| ZHANG P., Mak J.C.W., Man R.Y.K. and Leung S.W.S., Structure-activity relationships for anti-inflammatory effect of flavonoids, The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, 22-24 July 2015, National University of Singapore. 2015. |
| ZHAO Y., Vanhoutte P.M.G.R. and Leung S.W.S., α1-Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats , British Journal of Pharmacology. 2015, 172: 3687-3701. |
| Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Vascular nitric oxide: Beyond eNOS, Journal of Pharmacological Sciences. 2015, 129: 83-94. |
| Researcher : Li WSR |
| List of Research Outputs |
| Li W.S.R., Yang C., Shan L., Zhang Z., Wang Y., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., CHEUNG C. and Leung G.P.H., Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries, European Journal of Pharmacology. 2015, 761: 153-160. |
| Poon C.C., Li W.S.R., Seto S.W., Kong S.K., Ho H.P., Hoi M.P., Lee S.M., Ngai S.M., Chan S.W., Leung G.P.H. and Kwan Y.W., In vitro vitamin K2 and 1α,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice, European Journal of Pharmacology . 2015, 767: 30-40. |
| Researcher : Li X |
| List of Research Outputs |
| HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015. |
| He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300. |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Li X., Tse V.C., Au-Doung L.W., Wong I.C.K. and Chan E.W., The impact of ischaemic stroke on atrial fibrillation-related healthcare cost: a systematic review., Europace. 2016, pii: euw093. |
| Luk A.O.Y., Li X. and Chan J.C., Quality of care in patients with diabetic kidney disease in Asia: The Joint Asia Diabetes Evaluation (JADE) Registry, Diabetic Medicine. 2015. |
| Researcher : Lui WYV |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Lui WYV |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Completion Date: | 04/2016 |
| Project Title: | ALK inhibitors for head and neck cancer therapy |
| Investigator(s): | Lui WYV, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 07/2014 |
| Completion Date: | 04/2016 |
| Project Title: | MAPK1 Genomic Alterations as Predictor of Treatment Response and Driver for Tumor Growth in Head and Neck Cancer |
| Investigator(s): | Lui WYV, Chan YW, Sham PC, Wong TS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2014 |
| Completion Date: | 04/2016 |
| Project Title: | A Precision Therapeutic Tool for Head and Neck Cancer (HNC) |
| Investigator(s): | Lui WYV |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 03/2015 |
| Project Title: | HKU Overseas Fellowship Awards 2015-16 |
| Investigator(s): | Lui WYV |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 06/2015 |
| Researcher : Luo C |
| List of Research Outputs |
| YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Researcher : MAN KWD |
| List of Research Outputs |
| MAN K.W.D., CHOW Y.T., Casettari L., Gonzalez-Juarrero M. and Lam J.K.W., Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis, Advanced Drug Delivery Reviews. 2016, 102: 21-32. |
| Perinelli D.R., Casettari L., Cespi M., Fini F., MAN K.W.D., Giorgioni G., Canala S., Lam J.K.W., Bonacucina G. and Palmieri G.F., Chemical–physical properties and cytotoxicity of N-decanoyl amino acid-based surfactants: Effect of polar heads, Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016, 492: 38-46. |
| Researcher : MAN WC |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| Man W.C., Bai B. and Wang Y., Cloning and Characterization of Sirtuin3 (SIRT3) , Methods in Molecular Biology. 2016, 1436: 201-11. |
| Researcher : Man KCK |
| List of Research Outputs |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| Jin S., Boktor R.R., Man K.C.K. and Pitman A.G., Normal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy, Nuclear Medicine Communications. 2016, 1. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| Man K.C.K., Chan E.W., Coghill D., Ip P., Simonoff E., Chan P., LAU C.Y. and Wong I.C.K., Prenatal Antidepressant Exposure and the Risk of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder, 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 2015. |
| Roughead E.E., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Nguyen T.A., Ooba N., Park B.J., Sato T., Shin J.Y., Wang T., Griffiths J., Wong I.C.K., Kao Yang Y.H. and Pratt N.L., Variation in association between thiazolidinediones and heart failure across ethnic groups: Retrospective analysis of large healthcare claims databases in six countries, Drug Safety. 2015, 38 (9): 823-831. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Chan E.W., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November (oral).. 2015. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November (oral).. 2015. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November.. 2015. |
| Researcher : Man RYK |
| Project Title: | Vascular effects of 8-pCPT, an Epac activator |
| Investigator(s): | Man RYK, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 12/2015 |
| List of Research Outputs |
| ZHANG P., Mak J.C.W., Man R.Y.K. and Leung S.W.S., Structure-activity relationships for anti-inflammatory effect of flavonoids, The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, 22-24 July 2015, National University of Singapore. 2015. |
| Researcher : Man WC |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| Man W.C., Bai B. and Wang Y., Cloning and Characterization of Sirtuin3 (SIRT3) , Methods in Molecular Biology. 2016, 1436: 201-11. |
| Researcher : SING CW |
| List of Research Outputs |
| CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015. |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94. |
| Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern Chinese., Presented at the ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern chinese, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2016. 2015. |
| SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54. |
| Researcher : SONG E |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Wang Y., Song E., Bai B. and Vanhoutte P.M.G.R., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes., Pharmacology & Therapeutics. 2016, 158: 91-100. |
| Researcher : Song E |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Wang Y., Song E., Bai B. and Vanhoutte P.M.G.R., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes., Pharmacology & Therapeutics. 2016, 158: 91-100. |
| Researcher : TANG CTP |
| List of Research Outputs |
| TANG C.T.P. and Leung G.P.H., Characterization of 4-([4-(2-fluorophenyl) piperazin-1-yl] methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) as a Novel ENT2-Selective Inhibitor, Pharmacology 2015, London, United Kingdom,.15-17 December, 2015. |
| Researcher : Tang EHC |
| Project Title: | Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications. |
| Investigator(s): | Tang EHC, Vanhoutte PMGR, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2012 |
| Completion Date: | 07/2015 |
| Project Title: | Telomere-independent Rap1 contributes to inflammation during atherosclerosis |
| Investigator(s): | Tang EHC, Man RYK, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 12/2014 |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592. |
| Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomere-independent Rap1 Induces Cytokine Production In Pro-inflammatory Macrophages Through NFκB Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z., Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy, Journal of Diabetes Research. 2016, 2016: 1-10. |
| Vanhoutte P.M.G.R., Shimokawa H., Feletou M. and Tang E.H.C., Endothelial dysfunction and vascular disease – a thirtieth anniversary update. , Acta Physiol (Oxf). . 2015. |
| WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen species, Frontiers in Cardio Vascular Biology, Biennial meeting of the ESC Council on Basic Cardiovascular Science, Florence, Italy, July 8-10, 2016. |
| YING F., Cai Y. and Tang E.H.C., Deliciency of Prostaglandin E2 Receptor Subtype 4 Causes Dysregulation of Cholesterol Homeeostasis in Mice, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Ying F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype (EP4) regulates lipid droplet size and mitochondrial activity via FSP27 in white adipose tissue, 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine and the 10th Across the Strait Scientific Conference on Cardiovascular Science.. 2015. |
| Researcher : Tang HC |
| Project Title: | Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications. |
| Investigator(s): | Tang EHC, Vanhoutte PMGR, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2012 |
| Completion Date: | 07/2015 |
| Project Title: | Telomere-independent Rap1 contributes to inflammation during atherosclerosis |
| Investigator(s): | Tang EHC, Man RYK, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 12/2014 |
| List of Research Outputs |
| Researcher : Tom WM |
| Project Title: | VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning |
| Investigator(s): | Tom WM |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Researcher : Tse VC |
| List of Research Outputs |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Li X., Tse V.C., Au-Doung L.W., Wong I.C.K. and Chan E.W., The impact of ischaemic stroke on atrial fibrillation-related healthcare cost: a systematic review., Europace. 2016, pii: euw093. |
| Researcher : Vanhoutte P.M.G. |
| Project Title: | Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence |
| Investigator(s): | Vanhoutte PMGR, Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Project Title: | Human Prostacyclin Receptors and Endothelial Dysfunction |
| Investigator(s): | Vanhoutte PMGR, Xu A, Wang Y, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| List of Research Outputs |
| Researcher : Vanhoutte PMGR |
| Project Title: | Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence |
| Investigator(s): | Vanhoutte PMGR, Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Project Title: | Human Prostacyclin Receptors and Endothelial Dysfunction |
| Investigator(s): | Vanhoutte PMGR, Xu A, Wang Y, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| List of Research Outputs |
| BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Vascular responses in ageing: effects of obesity and/or constitutive activation of adenosine monophosphate-activated protein kinase (CA-AMPK), a TCM target, in endothelial cells, The 11th International Postgraduate Symposium on Chinese Medicine, August 14, 2015, Hong Kong. 2015. |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592. |
| Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomere-independent Rap1 Induces Cytokine Production In Pro-inflammatory Macrophages Through NFκB Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Biased Activation of Soluble Guanylyl Cyclase Can Cause Contraction of Isolated Arteries, Experimental Biology 2016, San Diego, California, U.S.A. FASEB J, 2016, 30. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Concentration-dependent vascular effects of divalent manganese, The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine & 10th Across the Strait Scientific Conference on Cardiovascular Science, 21 November 2015, Hong Kong. Journal of Hong Kong College of Cardiology, 2015, 23: 92. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions of isolated arteries to thymoquinone require biased activation of soluble guanylyl cyclase with resulting production of cyclic IMP, Pharmacology 2015, 15-17 December 2015, London, United Kingdom. 2015. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Vascular Effects of Divalent Manganese as a Cofactor of Soluble Guanylyl Cyclase, Experimental Biology 2016, San Diego, California, U.S.A.. FASEB J, 2016, 30. |
| Hansen P.B.L., DE MEY J.G.R. and Vanhoutte P.M.G.R., Endothelium-Dependent Hyperpolarizations from Health to Disease, Acta Physiologica. 2016. |
| LI J., Lin S., Vanhoutte P.M.G.R., Woo W.H.C. and Xu A., Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice , Circulation. 2016, 133: 2434-2446. |
| Leung S.W.S. and Vanhoutte P.M.G.R., Endothelium-dependent hyperpolarization: age, gender and high blood pressure , Endothelium-Dependent Hyperpolarizations in Health and Disease, 14 -17 September, 2015, Nyborg, Funen, Denmark . Acta Physiologica, 2015, 215 (Suppl. 703): 11. |
| Ling W.C., Lau Y.S., Murugan D.D., Vanhoutte P.M.G.R. and Mustafa M.R., Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle, Vascular Pharmacology. 2015, 74: 87-92. |
| Loh W.M., Ling W.C., Murugan D.D., Lau Y.S., Achike F.I., Vanhoutte P.M.G.R. and Mustafa M.R., Des-aspartate angiotensin I (DAA-I) reduces endothelial dysfunction in the aorta of the spontaneously hypertensive rat through inhibition of angiotensin II-induced oxidative stress, Vascular Pharmacology. 2015, 71: 151-158. |
| Mokhtar S.S., Vanhoutte P.M.G.R., Leung S.W.S., Yusof M.I., Wan Sulaiman W.A., Suppian R. and Rasool A.H., Endothelium dependent hyperpolarization-type relaxation compensates for attenuated nitric oxide-mediated responses in subcutaneous arteries of diabetic patients., Nitric Oxide. 2016, 53: 35-44. |
| Mokhtar S.S., Vanhoutte P.M.G.R., Leung S.W.S., Suppian R., Yusof M.I. and Rasool A.H., Reduced nitric oxide-mediated relaxation and endothelial nitric oxide synthase expression in the tail arteries of streptozotocin-induced diabetic rats., Eur J Pharmacol. 2016, 773: 78-84. |
| Vanhoutte P.M.G.R., Endothelial Lessons, Current Vascular Pharmacology. 2016, 14: 175-180. |
| Vanhoutte P.M.G.R., Shimokawa H., Feletou M. and Tang E.H.C., Endothelial dysfunction and vascular disease – a thirtieth anniversary update. , Acta Physiol (Oxf). . 2015. |
| Vanhoutte P.M.G.R., Kuala Lumpur Emerging in Vascular Biology, J Cardiovasc Pharmacol. 2015, 65: 297-298. |
| Vanhoutte P.M.G.R., Regenerated Endothelium and Its Senescent Response to Aggregating Platelets, Circulation Journal. 2016, 80: 783-790. |
| Vanhoutte P.M.G.R., Zhao Y., Xu A. and Leung S.W.S., Thirty Years of Saying NO, Circulation Research. 2016, 119: 375-396. |
| WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen species, Frontiers in Cardio Vascular Biology, Biennial meeting of the ESC Council on Basic Cardiovascular Science, Florence, Italy, July 8-10, 2016. |
| YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| ZHAO Y., Vanhoutte P.M.G.R. and Leung S.W.S., α1-Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats , British Journal of Pharmacology. 2015, 172: 3687-3701. |
| Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Vascular nitric oxide: Beyond eNOS, Journal of Pharmacological Sciences. 2015, 129: 83-94. |
| Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559. |
| Researcher : WONG HK |
| List of Research Outputs |
| Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592. |
| WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen species, Frontiers in Cardio Vascular Biology, Biennial meeting of the ESC Council on Basic Cardiovascular Science, Florence, Italy, July 8-10, 2016. |
| Researcher : WONG YS |
| List of Research Outputs |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Researcher : Wang Y |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | HERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis |
| Investigator(s): | Wang Y, Tse HF |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Activation of lipocalin-2 by deamidation in peri-vascular adipose tissues |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2 |
| Investigator(s): | Wang Y, Yuen KY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Regulation of T-cell maturation by adiponectin in thymus - role of CD100 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Timely resetting of mitochondrial function and mitonuclear protein balance by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice |
| Investigator(s): | Wang Y, Xu A, Xu C |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2015 |
| Completion Date: | 11/2015 |
| Project Title: | Breast Cancer Symposium; Modulation of breast cancer development in MMTV-PyVT mice by adiponectin: a perspective on tumor microenvironment |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2015 |
| Completion Date: | 09/2015 |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced clusterin (ApoJ) content of low density lipoproteins contribute to endothelial dysfunction in adiponectin-deficient mice, 83rd European Atherosclerosis Society Congress. ELSEVIER, 2015, 16(S2). |
| GUO Y., WANG L., Huang M., LEE I., Xu A. and Wang Y., Overexpression of SIRT1 in Adipose tissue Induces Clusterin-mediated Beneficial Metabolic Effects on Adiponectin Knockout Mice during Obesity, 76th Scientific sessions New Orleans, LA, June 10-14, 2016. |
| Guo Y., Xu A. and Wang Y., SIRT1 in endothelial cells as a novel target for the prevention of early vascular ageing, Journal of Cardiovascular Pharmacology. 2016, 67: 465-73. |
| Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015. |
| Man W.C., Bai B. and Wang Y., Cloning and Characterization of Sirtuin3 (SIRT3) , Methods in Molecular Biology. 2016, 1436: 201-11. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1& Epac2) in Inflammatory Pain, 11th International Symposium on Healthy Aging. 2016. |
| Wang Y., Adiponectin in regulating the lymphostromal interactions in thymus. Beijing Symposium on obesity and diabetes. April 9, 2016, 2016. |
| Wang Y., Anti-vascular ageing effects of endothelial SIRT1 - communicating with smooth muscle cells of the arteries. Experimental Biology, San Diego, CA, USA, April 2-6. 2016 FASEB J April 2016 30:1201.1, Experimental Biology. 2016. |
| Wang Y., Anti-vascular ageing effects of endothelial SIRT1. , 2015 Singapore Symposium on Metabolic Diseases. 2015. |
| Wang Y., Modulation of breast cancer development in MMTV-PyVT mice by adiponectin: A perspective on tumor microenvironment. Breast Cancer Symposium, San Francisco, CA, USA, September 25-27, 2015, 2015. |
| Wang Y., Song E., Bai B. and Vanhoutte P.M.G.R., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes., Pharmacology & Therapeutics. 2016, 158: 91-100. |
| YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776. |
| Ye D., Yang K.A.N.G.M.I.N., Chau H.A.U. .T.A.K., Xu A. and Wang Y., Lipocalin-2 Mediates Nonalcoholic Steatohepatitis by Promoting Neutrophil-Macrophage Crosstalk via The Induction of CXCR2, In: Rajiv Jalan, Journal of Hepatology. 2016. |
| Researcher : Wang Y. |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | HERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis |
| Investigator(s): | Wang Y, Tse HF |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Activation of lipocalin-2 by deamidation in peri-vascular adipose tissues |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2 |
| Investigator(s): | Wang Y, Yuen KY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Regulation of T-cell maturation by adiponectin in thymus - role of CD100 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Timely resetting of mitochondrial function and mitonuclear protein balance by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice |
| Investigator(s): | Wang Y, Xu A, Xu C |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2015 |
| Completion Date: | 11/2015 |
| Project Title: | Breast Cancer Symposium; Modulation of breast cancer development in MMTV-PyVT mice by adiponectin: a perspective on tumor microenvironment |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2015 |
| Completion Date: | 09/2015 |
| List of Research Outputs |
| Researcher : Wong ICK |
| Project Title: | Feasibility study of the effects of clonidine and melatonin treatment on sleep architecture of children with ADHD. |
| Investigator(s): | Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2015 |
| List of Research Outputs |
| CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015. |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chan E.W., LIU Q., CHUI S.L.C., SING C.W. and Wong I.C.K., Adverse Drug Reactions - Examples of detection of rare events using databases, B J Clin Pharmacol. 2015, 80: 855-861. |
| Chan E.W., Tang C., LAO S., Leung L.P., Tsui S.H., Ho H.F., Wong G., Kong D.C.M., Knott J.C. and Wong I.C.K., Management of acute agitation in Hong Kong and comparisons with Australasia, Emerg Med Australas. 2015, 27(6): 542-548. |
| Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588. |
| Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272. |
| Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272. |
| Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016. |
| Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73. |
| Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015. |
| Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674. |
| Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015. |
| He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300. |
| LAO S., CHUI S.L.C., Man K.C.K., LAU C.Y., Chan E.W. and Wong I.C.K., Medication safety research by observational study design, International Journal of Clinical Pharmacy. 2016, 38(3): 676-684. |
| LAU C.Y., Chan E.W. and Wong I.C.K., Efficacy and safety of dabigatran versus warfarin in patients with non-valvular atrial fibrillation., The Queen Elizabeth II Conference Centre, London, UK. 2015. |
| LAU C.Y., Murry M.L., El-Turki A., Saxena S., Ladhani S., Long P., Sharland M., Wong I.C.K. and Hsia Y., Impact of pneumococcal conjugate vaccines on childhood otitis media in the United Kingdom, Vaccine. 2015. |
| Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Prevalence of Potentially Inappropriate Prescribing Among Hong Kong Older Adults: A Comparison of the Beers 2003, Beers 2012, and Screening Tool of Older Person's Prescriptions and Screening Tool to Alert doctors to Right Treatment Criteria, Journal of the American Geriatrics Society . 2015, 63: 1471-2. |
| Lam M.P.S., Wong I.C.K. and Cheung B.M.Y., Using the prevalence of potentially inappropriate prescribing in Hong Kong as an example to illustrate the importance of content validation, 11th International Symposium on Healthy Aging, Hong Kong. 2016. |
| Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129. |
| Li X., Tse V.C., Au-Doung L.W., Wong I.C.K. and Chan E.W., The impact of ischaemic stroke on atrial fibrillation-related healthcare cost: a systematic review., Europace. 2016, pii: euw093. |
| Man K.C.K., Chan E.W., Coghill D., Ip P., Simonoff E., Chan P., LAU C.Y. and Wong I.C.K., Prenatal Antidepressant Exposure and the Risk of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder, 31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 2015. |
| Roughead E.E., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Nguyen T.A., Ooba N., Park B.J., Sato T., Shin J.Y., Wang T., Griffiths J., Wong I.C.K., Kao Yang Y.H. and Pratt N.L., Variation in association between thiazolidinediones and heart failure across ethnic groups: Retrospective analysis of large healthcare claims databases in six countries, Drug Safety. 2015, 38 (9): 823-831. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern Chinese., Presented at the ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern chinese, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2016. 2015. |
| SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Chan E.W., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November (oral).. 2015. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November (oral).. 2015. |
| Schuemie M., Man K.C.K., Park R.W., Kubota K., Cho S.Y., Ryan P. and Wong I.C.K., Mapping of drug coding system in Asia: South Korea, Hong Kong and Japan., 9th ISPE, Bangkok, Thailand, 14-16th November.. 2015. |
| TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Researcher : Wong KC |
| List of Research Outputs |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Wong K.C., NG W.H., Wong W.T. and Chiu P., Copper Hydride Catalyzed Reductive Claisen Rearrangements, Chemistry - A European Journal. 2016, 22: 3709-3712. |
| Researcher : Wong YS |
| List of Research Outputs |
| CHUI S.L.C., WONG Y.S., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Potential association between the use of oral fluoroquinolones and acute neuropsychiatric disorders in Hong Kong: A self-controlled case series study, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand November 14-16, 2015. |
| CHUI S.L.C., Chan E.W., WONG Y.S., ROOT A., DOUGLAS I.J. and Wong I.C.K., The Association Between Oral Fluoroquinolones and Seizures: A Hong Kong and United Kingdom Population-Based Self-Controlled Case Series Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| Chui S.L.C., Chan E.W., Wong Y.S., Root A., Douglas I.J. and Wong I.C.K., Association between oral fluoroquinolones and seizures: a self-controlled case series study., Neurology. 2016, 86(18): 1708-15. |
| WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., WEIDESELASSIE Y.G., SMEETH L. and Wong I.C.K., Myocardial Infarction Associated With Current Use of Helicobacter Pylori Eradication regimen Containing Clarithromycin: Self-Controlled Case Series, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., ROOT A., DOUGLAS I., CHUI S.L.C., Chan E.W., SMEETH L. and Wong I.C.K., Myocardial Infarction and Cardiac Death Associated with current Use of Clarithromycin: Cohort Study, 31st ICPE, Boston, MA USA, August 23-26, 2015. |
| WONG Y.S., CHUI S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Wong I.C.K. and Chan E.W., Neuropsychiatric disorders associated with the use of helicobacterpylori eradication therapy containing-clarithromyclin_self-controlled case series, The ISPE's 9th Asian Conference on Pfharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015. |
| Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926. |
| Researcher : Woo WHC |
| Project Title: | Role of Toll-like Receptor in Obesity-induced Non-Alcohol Fatty Liver Disease |
| Investigator(s): | Woo WHC, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2014 |
| Project Title: | Role of gut microbiota and prebiotics on glucose metabolism during pregnancy |
| Investigator(s): | Woo WHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Maternal Lipid Trafficking mediated by Gut Microbiota and TLR5 |
| Investigator(s): | Woo WHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| LI J., Lin S., Vanhoutte P.M.G.R., Woo W.H.C. and Xu A., Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice , Circulation. 2016, 133: 2434-2446. |
| Woo W.H.C., Interaction between Gut microbiota and Toll-like Receptor beyond Immunity, In: IPSEN/Science AAAS/HKU, 2016 Bridging Biomedical Worlds: Frontiers in Human Microbiota Symbiotic Interactions. 2016. |
| Woo W.H.C., CHEN J., LI J., YIU J.H.C. and Xu A., Metabolic Function of Toll like Receptor mediated by TRIF, In: Federation of American Societies for Experimental Biology, FASEB Summer Research Conference 2015, Nutritional Immunology: Role in Health and Disease. 2015. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Involvement of Toll-Like Receptor 5 Pathway in Hepatic Lipid Export, In: AAAS/Science Translational Medicine, IPSEN, HKU, Bridging Biomedical Worlds: Frontiers in Human Microbiota Symbiotic Interactions. 2016. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis by Toll-like Receptor 5 Pathway, Keystone Symposium on Molecular and Cellular Biology, Banff, Alberta, Canada, February 15-19, 2016. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis in Visceral Adipose Tissue by Toll-like Receptor 5 Pathway, In: Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong , 11th International Symposium on Healthy Aging. 2016. |
| Researcher : XU Y |
| List of Research Outputs |
| XU Y. and Lam J.K.W., Development of pH responsive cationic amphipathic LAH4-L1 peptide as a novel DNA vaccine delivery system, The 2015 Vaccine Summit, 13-15 Oct 2015, London, UK. 2015. |
| XU Y., Incorporation of Nuclear Translocation Signal in pH Responsive LAH4-L1 Peptide Enhanced DNA Transfection Efficiency, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2015. |
| Researcher : Xu C |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced clusterin (ApoJ) content of low density lipoproteins contribute to endothelial dysfunction in adiponectin-deficient mice, 83rd European Atherosclerosis Society Congress. ELSEVIER, 2015, 16(S2). |
| Researcher : YANG K |
| List of Research Outputs |
| Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687.. |
| YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| YANG K., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages via Inhibiting Mineralocorticoid Receptor Signaling, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2016. 2015. |
| YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Researcher : YING F |
| List of Research Outputs |
| CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936. |
| YING F., Cai Y. and Tang E.H.C., Deliciency of Prostaglandin E2 Receptor Subtype 4 Causes Dysregulation of Cholesterol Homeeostasis in Mice, Experimental Biology 2016, San Diego, April 2-6, 2016. |
| Ying F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype (EP4) regulates lipid droplet size and mitochondrial activity via FSP27 in white adipose tissue, 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine and the 10th Across the Strait Scientific Conference on Cardiovascular Science.. 2015. |
| Researcher : YIU JHC |
| List of Research Outputs |
| Woo W.H.C., CHEN J., LI J., YIU J.H.C. and Xu A., Metabolic Function of Toll like Receptor mediated by TRIF, In: Federation of American Societies for Experimental Biology, FASEB Summer Research Conference 2015, Nutritional Immunology: Role in Health and Disease. 2015. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Involvement of Toll-Like Receptor 5 Pathway in Hepatic Lipid Export, In: AAAS/Science Translational Medicine, IPSEN, HKU, Bridging Biomedical Worlds: Frontiers in Human Microbiota Symbiotic Interactions. 2016. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis by Toll-like Receptor 5 Pathway, Keystone Symposium on Molecular and Cellular Biology, Banff, Alberta, Canada, February 15-19, 2016. |
| YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis in Visceral Adipose Tissue by Toll-like Receptor 5 Pathway, In: Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong , 11th International Symposium on Healthy Aging. 2016. |
| Researcher : Ye D |
| Project Title: | Lipocalin-2 in acute and chronic liver diseases: focusing on neutrophil-mediated innate immune responses |
| Investigator(s): | Ye D, Wang Y, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 10/2013 |
| Project Title: | Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota |
| Investigator(s): | Ye D |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Researcher : ZHANG P |
| List of Research Outputs |
| ZHANG P., Effect of Flavonoids on the Release of Inflammatory Mediators in Airway Epithelial Cells, 20th Research Postgraduate Symposium, Hong Kong, December 2-3, 2016. 2015. |
| ZHANG P., Mak J.C.W., Man R.Y.K. and Leung S.W.S., Structure-activity relationships for anti-inflammatory effect of flavonoids, The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, 22-24 July 2015, National University of Singapore. 2015. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| Lam J.K.W., CHOW Y.T., ZHANG Y. and Leung S.W.S., siRNA Versus miRNA as Therapeutics for Gene Silencing, Molecular Therapy—Nucleic Acids. 2015, 4: e252. |
| Researcher : ZHAO Y |
| List of Research Outputs |
| Vanhoutte P.M.G.R., Zhao Y., Xu A. and Leung S.W.S., Thirty Years of Saying NO, Circulation Research. 2016, 119: 375-396. |
| ZHAO Y., Vanhoutte P.M.G.R. and Leung S.W.S., α1-Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats , British Journal of Pharmacology. 2015, 172: 3687-3701. |
| Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Vascular nitric oxide: Beyond eNOS, Journal of Pharmacological Sciences. 2015, 129: 83-94. |
| Researcher : Zhao Y |
| List of Research Outputs |
| Vanhoutte P.M.G.R., Zhao Y., Xu A. and Leung S.W.S., Thirty Years of Saying NO, Circulation Research. 2016, 119: 375-396. |
| ZHAO Y., Vanhoutte P.M.G.R. and Leung S.W.S., α1-Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats , British Journal of Pharmacology. 2015, 172: 3687-3701. |
| Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Vascular nitric oxide: Beyond eNOS, Journal of Pharmacological Sciences. 2015, 129: 83-94. |