Dept of Anaesthesiology

DEPT OF ANAESTHESIOLOGY

Researcher : Cai Y

Project Title:	Experimental Biology 2016; Inhibition Of COX-2/PGE2/EP4 Signaling Protects Against Post-hypoxic Apoptosis In H9C2 Cardiomyocytes
Investigator(s):	Cai Y
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomere-independent Rap1 Induces Cytokine Production In Pro-inflammatory Macrophages Through NFκB Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016.

Cai Y., Young Scientist Award, American Society of Pharmacology & Experimental Therapeutics. 2016.

Pang L., Cai Y., Ma H., Irwin M.G. and Xia Z., Inhibition of COX-2/PGE2/EP4 signaling protects against cell apoptosis during hypoxia/reoxygenation in H9C2 cardiomyocytes, Experimental Biology 2016.

Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z., Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy, Journal of Diabetes Research. 2016, 2016: 1-10.

Ying F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype (EP4) regulates lipid droplet size and mitochondrial activity via FSP27 in white adipose tissue, 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine and the 10th Across the Strait Scientific Conference on Cardiovascular Science.. 2015.

Researcher : Chan TCW

List of Research Outputs

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

Researcher : Cheung CW

Project Title:	Implantation of intrathecal pump for cancer pain patients
Investigator(s):	Cheung CW, Tsang WHJ
Department:	Anaesthesiology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

Project Title:	Cash donation to support service and clinical research (Pain Management)
Investigator(s):	Cheung CW, Irwin MG
Department:	Anaesthesiology
Source(s) of Funding:	Cash donation for supporting service and clinical research
Start Date:	11/2013

Project Title:	CXCL12/CXCR4 chemokine signaling in astrocytes following noxious stimulation
Investigator(s):	Cheung CW, Irwin MG
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Central CXCL12/CXCR4 axis contributes to the induction of peripheral neuropathic pain
Investigator(s):	Cheung CW, Irwin MG, Wong SCS
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	11th Annual Scientific Meeting of Neuromodulation Society of Australia and New Zealand; Endocannabinoid Activation of CB1 Receptors Contributes to Spinal Cord Stimulation-Induced Reversal of Neuropathic Pain
Investigator(s):	Cheung CW
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2016
Completion Date:	03/2016

List of Research Outputs

Chan A., QIU Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study, PlOS One. 2016, 11: e0149753.

Cheung C.W., Peer Reviewer, Clinical Neuropharmacology. 2016.

Cheung C.W., Peer Reviewer, Cochrane Review . 2016.

Cheung C.W., Peer Reviewer, Current Medicinal chemistry. 2016.

Cheung C.W., Peer Reviewer, IBRO Report. 2016.

Cheung C.W., Peer Reviewer, Journal of Oral and Facial Pain and Headache. 2016.

Cheung C.W., Peer Reviewer, Medicine. 2016.

Cheung C.W., Peer Reviewer, Progress in Neurobiology. 2016.

Cheung C.W., Speaker, 英國研究生教育與住院醫師培訓的現狀與思考, 徐州醫科大學2016屆麻醉學碩士研究生畢業答辯暨研究生教育研討會, 3 June 2016, Xuezhou, China. 2016.

Cheung C.W., Speaker, Acute Neuropathic Pain, Pain Association of Singapore Annual Scientific Meeting 2016, 5-6 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Acute Neuropathic Pain, Plenary talk from PAS, 5 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Analgesic Effects of Propofol: Evidence from Basic and Clinical Research, , The 5th Oriental Congress of Anaesthesiology and Preioperative Medicine, 17-19 June 2016, Shanghai, China. 2016.

Cheung C.W., Speaker, Audit in Pain Management: Can it help to improve postoperative pain?, 第五屆兩岸四地麻醉安全學術交流會. 30 October 2015 - 1 November 2015, Changzhou, China. 2015.

Cheung C.W., Speaker, Buprenorphine: The novel treatment for pain management, Pain and Geriatric Department, 4 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Chronic Pain in children, Pediatric Anesthesia and Anaglesia Forum 2015, 19 Sept 2015, Macau. 2015.

Cheung C.W., Speaker, ERAS 的內涵是甚麼? 怎麼做? 舒適化醫療的內涵是甚麼? 實施舒適化醫療麻醉醫師能做甚麼? 怎麼做?, 2016 Congress of Chinese Society of Integrative Anaesthesiology (CSIA), 23-26 June 2016, Chengzhou, China.. 2016.

Cheung C.W., Speaker, Effects and mechanisms of epidural spinal cord stimulation in neuropathic pain, The EU - China (Sichuan) Translational Neuroscience and Sichuan - Limburg Health Cooperation Seminar, 8-11 November 2015, Chengdu, China. 2015.

Cheung C.W., Speaker, Mix Pathology of Pain: Recognizing and establishing treatment strategy, Pain Summit 17 October 2015, HK. 2015.

Cheung C.W., Speaker, Moving Forward: The next generation opioids and its implication in our practice, Mundipharma sponsored tea time talk, 5 March 2016, Singapore . 2016.

Cheung C.W., Speaker, Optimizing opioid therapy and reducing side effects: Managing short and long term treatment outcome, NCCS Palliative Centre Talk 4 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Optimizing opioid therapy and reducing side effects: Managing short and long term treatment outcome, KTPH Geriatric Department talk, 3 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Optimizing opioid therapy and reducing side effects: Managing short and long term treatment outcome, NUH Pain Centre talk, 3 March 2016, Singapore. 2016.

Cheung C.W., Speaker, Propofol and Pain: the evidence, 2016 Congress of Chinese Society of Integrative Anaesthesiology, 23-26 June 2016, Chengzhou, China. 2016.

Cheung C.W., Speaker, Randomized Controlled Trail: How to plan and organise, 安徽省醫師協會麻醉科醫師分會第一次學術會議, 6-7 November 2015, Heifei, China. 2015.

Cheung C.W., Speaker, Role of oral opioid in post-operative pain management, Pain Sumit 17 October 2015, HK. 2015.

Cheung C.W., Speaker, Spinal Cord Stimulation for Chronic Pain, Annual Scientific Meeting in Anaesthesiology 2015 , 14-15 November 2015, HK. 2015.

Cheung C.W., Speaker, Spinal Cord Stimulator - Application and Limitation, The 11th Rehabilitation Symposium cum the 4th Sir Harry Fang Oration, 11 Oct 2015, HK. 2015.

Cheung C.W., Speaker, TIVA & Precision Medicine, In: 27-29 November 2015, Shanghai, China, 2015 Shanghai-Singapore-Taiwan-Hong Kong-Macao Anesthetic Symposium 2015. 2015.

Cheung C.W., speaker, Review on Cancer Pain Management, Continuing Medical Education, 18 November 2015, HK. 2015.

Cheung C.W., 使用脊柱神經刺激治療長期背神經失敗綜合症, 第五屆粵港澳台麻醉學學術會議暨2015廣東省醫學會麻醉學學術年會, 7th-9th August, 2015, Dongguan, China. 2015.

LUO X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. , In: Xin Luo, Xiaoming Amy Wang, Zhengyuan Xia, Sookja Kim Chung and Chi Wai Cheung, Review in Neurosciences. 2015, 27(1): 83-92.

Lam D., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories, Medicine. 2015, 94: e1944.

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

Sun L.T. and Cheung C.W., Effects and mechanisms of epidural spinal cord stimulation in neuropathic pain, 2015.

Sun L.T. and Cheung C.W., Effects and mechanisms of epidural spinal cord stimulation in neuropathic pain, EU-CHINA Symposium in Translational Neuroscience. 2015.

Sun L.T., TAI W.L., Mitchell R., Fleetwood-Walker S., Joosten E. and Cheung C.W., Endocannabinoid Activation of CB1 Receptors Contributes to Spinal Cord Stimulation-Induced Reversal of Neuropathic Pain, International Neuromodulation Society . 2016.

Sun L.T., Tai W.L., Mitchell R., Fleetwood-Walker S., Joosten E.A.J. and Cheung C.W., Endocannabinoid Activation of CB1 receptors contributes to spinal cord stimulation-induced reversal of neuropathic pain., 11th Annual Scientific Meeting, Neuromodulation Mainstream Medicine, Neuromodulation Society of Australia and New Zealand 2016. 12-13 March 2016.

Wong K.L., Cheung C.W., Chao C.C., Tzu H.S. and Leung Y.M., The Protective Effects of Catechin on Palmitic Acid-Induced Cytotoxicity in Mouse Brain Endothelial Cell, In: Kar Lok Wong, Chi Wai Cheung, C C Chao, Tzu Hui Su, Y M Leung, INTERNATIONAL ACADEMY OF CARDIOLOGY, ANNUAL SCIENTIFIC SESSIONS 2015, 20th WORLD CONGRESS ON HEART DISEASE, VANCOUVER, BC, CANADA,. 2015.

Researcher : Choi SW

List of Research Outputs

Chan A., QIU Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study, PlOS One. 2016, 11: e0149753.

Choi S.W., Lam D.M. and Irwin M.G., Ghost in the machine, Hong Kong Medical Journal. 2016, 22(3): 292-293.

Lam D., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories, Medicine. 2015, 94: e1944.

Researcher : Chu MT

List of Research Outputs

Wong G.T.C., HUANG C., Ng T.W., Chu M.T. and Chang R.C.C., Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery, Euroanaesthesia 2016.

Researcher : HUANG C

List of Research Outputs

HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship between tau protein phosphorylation and surgical trauma in post operative cognitive dysfunction., The 11th International Conference on Healthy Aging. 2016, 62.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship of tau protein and inflammation within cognitive dysfunction induced by laparotomy, International Alzheimer’s Disease Conference 2016. 63.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The role of tau protein and inflammation within cognitive dysfunction induced by laparotomy in young animal. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 36.

Wong G.T.C., HUANG C., Ng T.W., Chu M.T. and Chang R.C.C., Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery, Euroanaesthesia 2016.

Researcher : Irwin MG

Project Title:	A comparative study of hydroxyethyl starch (130/0.4) and gelatin on the immune response in paediatric scoliosis surgery
Investigator(s):	Irwin MG, Wylie SJ
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	Radiofrequency therapy for chronic and cancer pain patient
Investigator(s):	Irwin MG, Cheung CW
Department:	Anaesthesiology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Effects of ketamine on the CGRP-CRLR ligand-receptor complex and pain signaling
Investigator(s):	Irwin MG, Cheung CW
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	The effect of over-expression of astrocytic ET-1 on Complex Regional Pain Syndrome I in a chronic post-ischaemia pain model.
Investigator(s):	Irwin MG, Cheung CW, Wong SCS
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3
Investigator(s):	Irwin MG, Xia Z, Vanhoutte PMGR, Wong GTC
Department:	Anaesthesiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

List of Research Outputs

Chan A., QIU Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study, PlOS One. 2016, 11: e0149753.

Choi S.W., Lam D.M. and Irwin M.G., Ghost in the machine, Hong Kong Medical Journal. 2016, 22(3): 292-293.

Chow K.Y., Liu S.E. and Irwin M.G., New therapy in cardioprotection, Curr Opin Anaesthesiol. 2015, 28(4): 417-423.

Gan X., Xing D., Su G., Li S., Luo G., Irwin M.G., Xia Z., LI H. and Hei Z., Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation, Oxidative Medicine and Cellular Longevity. 2015, 2015: 1-15.

HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226.

He S.F., Jin S.Y., Wu H., Wang B., Wu Y.X., Zhang S.J., Irwin M.G., Wong T.M. and Zhang Y., Morphine preconditioning confers cardioprotection in doxorubicine-induced failing rat hearts via ERK/GSK3b pathway independent of P13K/Akt., Toxicol appl Pharmacol. 2015, 288(3): 349-358.

Irwin M.G., Advisory Board Member, Medical Grapevine . 2016.

Irwin M.G., Annual Scientific Meeting, Association of Anaesthetists Great Britain and Ireland, Edinburgh. 2015.

Irwin M.G., Annual Scientific Meeting, European Society of anaesthesia, London. 2016.

Irwin M.G., Association of Anaesthetists Great Britain and Ireland, Annual Scientific Meeting. 2015.

Irwin M.G., Board Member, Children's Surgical Centre, Cambodia. 2016.

Irwin M.G., Committee Member, Health Services Research Committee. 2016.

Irwin M.G., Editorial Board Member, Acta Anaesthesia Taiwanica. 2016.

Irwin M.G., Editorial Board Member, Anaesthesia. 2016.

Irwin M.G., Editorial Board Member, Anaesthesia and Intensive Care Medicine. 2016.

Irwin M.G., Editorial Board Member, CPD Anaesthesia (UK). 2016.

Irwin M.G., Editorial Board Member, Expert Opinion on Pharmacotherapy. 2016.

Irwin M.G., Editorial Board Member, Journal of International Medical Research. 2016.

Irwin M.G., Editorial Board Member, Perioperative Medicine. 2016.

Irwin M.G., Editorial Board Memebr, Pain Research and Treatment. 2016.

Irwin M.G., Grants reviewer, ANZCA Clinical Trials Network. 2016.

Irwin M.G., Grants reviewer, Australian Academy of Health and Medical Sciences. 2016.

Irwin M.G., Grants reviewer, Health Services Research Committee/Health Care & Promotion Fund. 2016.

Irwin M.G., Grants reviewer, Hong Kong Research Grants Council. 2016.

Irwin M.G., Grants reviewer, National Institute of Academic Anaesthesia, UK. 2016.

Irwin M.G., Grants reviewer, National Natural Science Foundation of China. 2016.

Irwin M.G., Grants reviewer, SK Yee Medical Foundation. 2016.

Irwin M.G., Grants reviewer, The Netherlands Organisation for Health Research and Development . 2016.

Irwin M.G., Guest Editor, British Journal of Anaestheisa (Vascular Anaesthesia Supplement 2016). 2016.

Irwin M.G., In Fleisher: Essence of Anesthesia Practice, 4e. Springer, In: Irwin MG, Non-Statin Hypolipidemic Agents. 2016.

Irwin M.G., Meeting, Forum on Intravenous Anaesthesia, Taiwan. 2016.

Irwin M.G., Member, General Medical Council, UK. 2016.

Irwin M.G., Member, HK Hospital Authority Expert Panel in Anaesthesiology. 2016.

Irwin M.G., Member, Royal College of Anaesthetists. 2016.

Irwin M.G., Members meeting, American Society of Anesthesiologists, San Diego. 2015.

Irwin M.G., Pediatric Sedation: The Asian Approach. , Pediatric Sedation Outside of the Operating Room.. 2016.

Irwin M.G., Peer Reviewer, In: Journal of Paediatrics, Obstetrics and Gynaecology, 2016.

Irwin M.G., Peer Reviewer, Asean Journal of Anaesthesiology. 2016.

Irwin M.G., Peer Reviewer, Asian Journal of Maxillofacial Surgery. 2016.

Irwin M.G., Peer Reviewer, British Journal of Anesthesia. 2016.

Irwin M.G., Peer Reviewer, British Journal of Surgery. 2016.

Irwin M.G., Peer Reviewer, Canadian Journal of Anaesthesia. 2016.

Irwin M.G., Peer Reviewer, Canadian Journal of Physiology & Pharmacology. 2016.

Irwin M.G., Peer Reviewer, Diabetes. 2016.

Irwin M.G., Peer Reviewer, European Journal of Pharmacology. 2016.

Irwin M.G., Peer Reviewer, Expert Opinion on Investigational Drugs. 2016.

Irwin M.G., Peer Reviewer, International Immuopharmacology. 2016.

Irwin M.G., Peer Reviewer, Journal of Cardiothoracic and Vascular Anesthesia. 2016.

Irwin M.G., Peer Reviewer, Journal of Molecular and Cellular Cardiology. 2016.

Irwin M.G., Peer Reviewer, Journal of Neuroscience Methods. 2016.

Irwin M.G., Peer Reviewer, Journal of Pharmaceutical & Biomedical Analysis. 2016.

Irwin M.G., Peer Reviewer, Journal of clinical Anaesthesia. 2016.

Irwin M.G., Peer Reviewer, Medical Science Monitor. 2016.

Irwin M.G., Peer Reviewer, Oncotarget. 2016.

Irwin M.G., Peer Reviewer, Surgical Practice. 2016.

Irwin M.G., Peer reviewer, Anaesthesia. 2016.

Irwin M.G., Peer reviewer, Anaesthesia and Intensive Care. 2016.

Irwin M.G., Peer reviewer, Anesthesia and Analgesia. 2016.

Irwin M.G., Peer reviewer, Anesthesiology. 2016.

Irwin M.G., Peer reviewer, Lancet. 2016.

Irwin M.G., Perioperartive Fluid Therapy, In: Irwin MG, Lui SE, Ward P. , Fluid therapy for the high risk surgery patient. 2016.

Irwin M.G., President, Asia-Oceanic Society for Intravenous Anaesthesia. 2016.

Irwin M.G., Reviewer, Innovational Research Incentives Scheme Veni, Netherlands Organisation. 2015.

Irwin M.G., Senior Editor, Hong Kong Medical Journal. 2016.

Irwin M.G., Winter Scientific Meeting, Association of Anaesthetist Great Britain and Ireland, London. 2016.

KANDULA V., Kosuru R., Li H., YAN D., Zhu Q., Lian Q., Ge R., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetiol . 2016, 15: 44.

Lam D., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories, Medicine. 2015, 94: e1944.

Li B.L., Zhang N., Huang J.X., QIU Q., Tian H., Ni J., Song X.R., Yuen V.M.Y. and Irwin M.G., A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops, Anaesthesia. 2016, 71(5): 522-528.

Li H., Irwin M.G. and Xia Z., Caveolin-3/AdipoR1 dependent mitochondrial STAT3 activation in ischemic postconditioning cardioprotection in diabetes, The 18th South China International Congress of Cardiology. 2016.

Li H., Yao W., LIU Z., Wang S., Irwin M.G. and Xia Z., Diabetes abrogates the cardioprotective effects of ischemic postconditioning by impairing AdipoR1/Caveolin-3/STAT3 signaling, American Heart Association Scientific Sessions. 2015.

Li H., Yao W., LIU Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats, Diabetes. 2016, 65: 942-955.

Li H., WANG C., Chen C., Irwin M.G. and Xia Z., Repeated non-invasive limb ischemic preconditioning confers cardioprotection in diabetes by reducing necroptosis through STAT3 activation that is PKCɛ/Caveolin-3 dependent, Experimental Biology. 2016.

Li H., Irwin M.G. and Xia Z., Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection: The Importance of AdipoR1/Caveolin-3-dependent STAT3 Activation, The 1st Annual Meeting of the Chinese Society of Cardiothoracic and Vascular Anesthesiology/ 10th International Chinese Cardiovascular Anesthesia Forum. 2015.

Li S., Xu J., Yao W., Li H., Liu Q., Xiao F., Irwin M.G., Xia Z. and Ruan W., Sevoflurane pretreatment attenuates TNF-a-induced human endothelial cell dysfunction through activating eNOS/NO pathway, Biochem Biophys Res Commun. 2015, 460(3): 879-886.

Lin J., Wang T., Li Y., Wang M., Li H., Xia Z. and Irwin M.G., N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats, J Diabetes Res . 2016, 2016: 9213034.

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

McLintic A.J. and Irwin M.G., Is the injury out on consensus opinion?, Anaesthesia. 2016, 71(3): 256-260.

Pang L., Cai Y., Ma H., Irwin M.G. and Xia Z., Inhibition of COX-2/PGE2/EP4 signaling protects against cell apoptosis during hypoxia/reoxygenation in H9C2 cardiomyocytes, Experimental Biology 2016.

Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z., Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy, Journal of Diabetes Research. 2016, 2016: 1-10.

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

Tian Y., LI H., Liu P., Xu J.M., Irwin M.G., Xia Z. and Tian G., Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans, Mediators of Inflammation. 2015, 2015: 1-12.

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

WANG Y., Li H., Huang H., Liu S., Irwin M.G. and Xia Z., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/STAT3 signaling, Clin Sci (Lond). 2016, 130: 801-12.

Wong S.C.S. and Irwin M.G., Anaesthesia for fractured neck femur, Anaesthesia & Intensive Care Medicine. 2015, 16: 103-107.

Wong S.C.S. and Irwin M.G., Peri-operative cardiac protection for non-cardiac surgery, Anaesthesia. 2016, 71: 29-39.

Researcher : Joosten EAJ

List of Research Outputs

Sun L.T., Tai W.L., Mitchell R., Fleetwood-Walker S., Joosten E.A.J. and Cheung C.W., Endocannabinoid Activation of CB1 receptors contributes to spinal cord stimulation-induced reversal of neuropathic pain., 11th Annual Scientific Meeting, Neuromodulation Mainstream Medicine, Neuromodulation Society of Australia and New Zealand 2016. 12-13 March 2016.

Researcher : KANDULA V

List of Research Outputs

KANDULA V., Kosuru R., Li H., YAN D., Zhu Q., Lian Q., Ge R., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetiol . 2016, 15: 44.

Researcher : LEUNG WYY

List of Research Outputs

LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71.

LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64.

Researcher : LI H

List of Research Outputs

Gan X., Xing D., Su G., Li S., Luo G., Irwin M.G., Xia Z., LI H. and Hei Z., Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation, Oxidative Medicine and Cellular Longevity. 2015, 2015: 1-15.

Gao S., Yang Z., Shi R., Xu D., Li H., Xia Z., Wu Q., Yao S., Wang T. and Yuan S., Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling, Eur J Pharmacol. 2016, 779: 111-21.

Gao S., Zhu Y., Li H., Xia Z., Wu Q., Yao S. and Wang T., Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation, Int Immunopharmacol. 2016, 38: 395-401.

Han X., Yao W., LIU Z., Li H., Zhang Z., Hei Z. and Xia Z., Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner, Oxid Med Cell Longev . 2016, 2016: 9303606.

KANDULA V., Kosuru R., Li H., YAN D., Zhu Q., Lian Q., Ge R., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetiol . 2016, 15: 44.

Li H., Irwin M.G. and Xia Z., Caveolin-3/AdipoR1 dependent mitochondrial STAT3 activation in ischemic postconditioning cardioprotection in diabetes, The 18th South China International Congress of Cardiology. 2016.

Li H., Yao W., LIU Z., Wang S., Irwin M.G. and Xia Z., Diabetes abrogates the cardioprotective effects of ischemic postconditioning by impairing AdipoR1/Caveolin-3/STAT3 signaling, American Heart Association Scientific Sessions. 2015.

Li H., Yao W., LIU Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats, Diabetes. 2016, 65: 942-955.

Li H., WANG C., Chen C., Irwin M.G. and Xia Z., Repeated non-invasive limb ischemic preconditioning confers cardioprotection in diabetes by reducing necroptosis through STAT3 activation that is PKCɛ/Caveolin-3 dependent, Experimental Biology. 2016.

Li H., Irwin M.G. and Xia Z., Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection: The Importance of AdipoR1/Caveolin-3-dependent STAT3 Activation, The 1st Annual Meeting of the Chinese Society of Cardiothoracic and Vascular Anesthesiology/ 10th International Chinese Cardiovascular Anesthesia Forum. 2015.

Lin J., Wang T., Li Y., Wang M., Li H., Xia Z. and Irwin M.G., N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats, J Diabetes Res . 2016, 2016: 9213034.

Tian Y., LI H., Liu P., Xu J.M., Irwin M.G., Xia Z. and Tian G., Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans, Mediators of Inflammation. 2015, 2015: 1-12.

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

WANG Y., Li H., Huang H., Liu S., Irwin M.G. and Xia Z., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/STAT3 signaling, Clin Sci (Lond). 2016, 130: 801-12.

Wang L., Wang T., Li H., Liu Q., Zhang Z., Xie W., Feng Y., Socorburam T., Wu G. and Xia Z., Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice, PloS One. 2016, 11(5): e0155723.

Xia R., Xu J., Yin H., Wu H.Z., Xia Z., Zuo D., Xia Z.Y., Zhang L.P., LI H. and Xiao X., Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients, Mediators of Inflammation. 2015, 2015: 1-7.

Zhao W., Liu Z., Yu X., Lai L., Li H., LIU Z., Li L., Jiang S., Xia Z. and Xu S., iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways, Proteomics. 2015, 16: 564-75.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Researcher : LIU Y

List of Research Outputs

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Researcher : LIU Z

List of Research Outputs

Han X., Yao W., LIU Z., Li H., Zhang Z., Hei Z. and Xia Z., Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner, Oxid Med Cell Longev . 2016, 2016: 9303606.

Li H., Yao W., LIU Z., Wang S., Irwin M.G. and Xia Z., Diabetes abrogates the cardioprotective effects of ischemic postconditioning by impairing AdipoR1/Caveolin-3/STAT3 signaling, American Heart Association Scientific Sessions. 2015.

Li H., Yao W., LIU Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats, Diabetes. 2016, 65: 942-955.

Zhao W., Liu Z., Yu X., Lai L., Li H., LIU Z., Li L., Jiang S., Xia Z. and Xu S., iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways, Proteomics. 2015, 16: 564-75.

Researcher : LUO X

List of Research Outputs

LUO X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. , In: Xin Luo, Xiaoming Amy Wang, Zhengyuan Xia, Sookja Kim Chung and Chi Wai Cheung, Review in Neurosciences. 2015, 27(1): 83-92.

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Researcher : Law Min J

List of Research Outputs

Samartzis D., Bow H.Y.C., Cheung J.P.Y., Sham P.L.M., Mak K.C., Cheung W.Y., Wong Y.W., Luk K.D.K., Cheung K.M.C. and Law Min J., Efficacy of Postoperative Pain Management Using Continuous Local Anesthetic Infusion at the Iliac Crest Bone Graft Site in Patients with Adolescent Idiopathic Scoliosis: A Parallel, Double-Blinded, Randomized Controlled Pilot Trial, Global Spine Journal. Global Spine Journal, 2015, 6(3): 220-8.

Researcher : Lee Y

List of Research Outputs

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

Researcher : Lei S

List of Research Outputs

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Xue R., Lei S., Xia Z., Wu Y., Meng Q., Zhan L., Su W., Liu H., Xu J., Liu Z., Zhou B. and Xia Z., Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways, Clinical Science. 2016, 130: 377-392.

Researcher : Li H

Project Title:	Experimental biology 2016; Repeated Non-invasive Limb Ischemic Preconditioning Confers Cardioprotection in Diabetes by Reducing Necroptosis Through STAT3 Activation That is PKCepsilon/Caveolin-3 Dependent'
Investigator(s):	Li H
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Researcher : Liu SE

List of Research Outputs

Chow K.Y., Liu S.E. and Irwin M.G., New therapy in cardioprotection, Curr Opin Anaesthesiol. 2015, 28(4): 417-423.

Researcher : Low SJ

List of Research Outputs

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

Researcher : MAO X

List of Research Outputs

Cao S., Liu Y., Wang H., MAO X., Chen J., Liu J., Xia Z., Zhang L., Liu X. and YU T., Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts, PeerJ. 2016, 4: e1706.

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

Researcher : Ng JKF

Project Title:	The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):	Ng KFJ, Leung SWS
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2012

Researcher : Ng KFJ

Project Title:	The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):	Ng KFJ, Leung SWS
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2012

Researcher : Ng TW

Project Title:	Evaluating the effect of prostaglandin-E2 EP4 receptor signaling
Investigator(s):	Ng TW, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

List of Research Outputs

Wong G.T.C., HUANG C., Ng T.W., Chu M.T. and Chang R.C.C., Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery, Euroanaesthesia 2016.

Researcher : QIU Q

List of Research Outputs

Chan A., QIU Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study, PlOS One. 2016, 11: e0149753.

Li B.L., Zhang N., Huang J.X., QIU Q., Tian H., Ni J., Song X.R., Yuen V.M.Y. and Irwin M.G., A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops, Anaesthesia. 2016, 71(5): 522-528.

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

Researcher : Rodrigo MRC

Project Title:	4th South Asian Confederation of Anaesthesiologists Congress Anaesthesia for Orthognathic Surgery
Investigator(s):	Rodrigo MRC
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/1999

Project Title:	The Association of Dental Anaesthetists 25th Anniversary Summer Scientific Meeting Patient Controlled Sedation with Propolfol
Investigator(s):	Rodrigo MRC
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2002

Researcher : Sun LT

List of Research Outputs

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Sun L.T. and Cheung C.W., Effects and mechanisms of epidural spinal cord stimulation in neuropathic pain, 2015.

Sun L.T. and Cheung C.W., Effects and mechanisms of epidural spinal cord stimulation in neuropathic pain, EU-CHINA Symposium in Translational Neuroscience. 2015.

Sun L.T., TAI W.L., Mitchell R., Fleetwood-Walker S., Joosten E. and Cheung C.W., Endocannabinoid Activation of CB1 Receptors Contributes to Spinal Cord Stimulation-Induced Reversal of Neuropathic Pain, International Neuromodulation Society . 2016.

Sun L.T., Tai W.L., Mitchell R., Fleetwood-Walker S., Joosten E.A.J. and Cheung C.W., Endocannabinoid Activation of CB1 receptors contributes to spinal cord stimulation-induced reversal of neuropathic pain., 11th Annual Scientific Meeting, Neuromodulation Mainstream Medicine, Neuromodulation Society of Australia and New Zealand 2016. 12-13 March 2016.

Researcher : TAI WL

List of Research Outputs

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Sun L.T., TAI W.L., Mitchell R., Fleetwood-Walker S., Joosten E. and Cheung C.W., Endocannabinoid Activation of CB1 Receptors Contributes to Spinal Cord Stimulation-Induced Reversal of Neuropathic Pain, International Neuromodulation Society . 2016.

Sun L.T., Tai W.L., Mitchell R., Fleetwood-Walker S., Joosten E.A.J. and Cheung C.W., Endocannabinoid Activation of CB1 receptors contributes to spinal cord stimulation-induced reversal of neuropathic pain., 11th Annual Scientific Meeting, Neuromodulation Mainstream Medicine, Neuromodulation Society of Australia and New Zealand 2016. 12-13 March 2016.

Researcher : Tai WL

List of Research Outputs

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Researcher : Vanhoutte PMGR

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Human Prostacyclin Receptors and Endothelial Dysfunction
Investigator(s):	Vanhoutte PMGR, Xu A, Wang Y, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Wang Y., Song E., Bai B. and Vanhoutte P.M.G.R., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes., Pharmacology & Therapeutics. 2016, 158: 91-100.

Researcher : WANG C

List of Research Outputs

Li H., WANG C., Chen C., Irwin M.G. and Xia Z., Repeated non-invasive limb ischemic preconditioning confers cardioprotection in diabetes by reducing necroptosis through STAT3 activation that is PKCɛ/Caveolin-3 dependent, Experimental Biology. 2016.

Researcher : WANG Y

List of Research Outputs

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

WANG Y., Li H., Huang H., Liu S., Irwin M.G. and Xia Z., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/STAT3 signaling, Clin Sci (Lond). 2016, 130: 801-12.

Researcher : Wang XMA

List of Research Outputs

LUO X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. , In: Xin Luo, Xiaoming Amy Wang, Zhengyuan Xia, Sookja Kim Chung and Chi Wai Cheung, Review in Neurosciences. 2015, 27(1): 83-92.

Researcher : Wong GTC

Project Title:	The cardiac preconditioning effect of surgery patients
Investigator(s):	Wong GTC, Irwin MG, Hiong YT, Das SR
Department:	Anaesthesiology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	10/2007

Project Title:	Evaluation of the association between the stress and inflammatory response with cognitive function after surgery in aged mice
Investigator(s):	Wong GTC, Chang RCC
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2014

Project Title:	The impact of preoperative and postoperative haemoglobin level on rehabilitation duration in fracture hip patients
Investigator(s):	Wong GTC, Leung FKL
Department:	Anaesthesiology
Source(s) of Funding:	AOTrauma
Start Date:	09/2014

Project Title:	The evaluation of insulin resistance as a precipitating factor for postoperative cognitive dysfunction
Investigator(s):	Wong GTC, Chang RCC
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Euroanaesthesia 2016; Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery
Investigator(s):	Wong GTC
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016
Completion Date:	05/2016

Project Title:	Forced resistant exercise preconditioning reduces postoperative cognitive dysfunction in mice
Investigator(s):	Wong GTC, Chang RCC
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chu M.T., Lee D.K.M., Wong D.P.K., Wong G.T.C. and Yue K.K.M., Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals, Metabolic Brain Disease. 2016.

HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship between tau protein phosphorylation and surgical trauma in post operative cognitive dysfunction., The 11th International Conference on Healthy Aging. 2016, 62.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship of tau protein and inflammation within cognitive dysfunction induced by laparotomy, International Alzheimer’s Disease Conference 2016. 63.

HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The role of tau protein and inflammation within cognitive dysfunction induced by laparotomy in young animal. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 36.

LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71.

LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64.

LIU K.L., Hurry M.E.D., DeFelice J., Lai H.M., Pearce R.K.B., Wong G.T.C., Chang R.C.C. and Gentleman S.M., Bringing CLARITY to human brain: visualisation of Lewy pathology in three-dimensions. , Neuropathology and Applied Neurobiology. 2015, 1-15.

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

Wong G.T.C., HUANG C., Ng T.W., Chu M.T. and Chang R.C.C., Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery, Euroanaesthesia 2016.

Wong G.T.C., Examiner For Phd Thesis Titled "role And Mechanism Of Adiponectin In Ishemic Postconditioning Cardioprotection Against Myocardial Ischemic Reperfusion Injury In Type 1 Diabetes, 2015.

Wong G.T.C., External Examiner for PhD Thesis titled "Delirium in the Intensive Care Unit after Cardiac Surgery", Chinese University of Hong Kong. 2015.

Wong G.T.C., Integrative Medicine and Global Health, 2015 East-West Alliance Global Symposium. 2015.

Wong G.T.C., Internal Examiner of PhD thesis titled, The Role of PKC-Epsilon in Non-invasive Limb Ischemic Preconditioning Against Myocardial Ischemia Reperfusion Injury in Diabetes. 2016.

Wong G.T.C., Journal of Alzheimer's Disease, Associate Editor , 2016.

Wong G.T.C., Perioperative Cerebral Protection, Asian Anaesthesia Forum Chulalongkorn Hospital. 2016.

Wong G.T.C., Reviewer for manuscript number JNIP-D-15-00058 Journal of Neuroimmune Pharmacology , 2015.

Wong G.T.C., Reviewer of manuscript number HKMJ-4661, 2015.

Wong G.T.C., TIVA and Cerebral Protection, TCI conference,T aiwan Society of Anesthesiologists. 2016.

Researcher : Wong SCS

Project Title:	Spinal neuron plasticity following propofol treatment in vitro
Investigator(s):	Wong SCS, Cheung CW
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Intrathecal administration of RhoA, ROCK and ERK inhibitors reduces thermal and inflammatory hyperalgesia in DLC2-/- (knockout) mice
Investigator(s):	Wong SCS, Chung SK, Cheung CW
Department:	Anaesthesiology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Chan A., QIU Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study, PlOS One. 2016, 11: e0149753.

Lam D., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories, Medicine. 2015, 94: e1944.

Low S.J., Wong S.C.S., QIU Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last two decades, In: Sheng Jia Low, Stanley Sau Ching Wong, Qiu Qiu, Yvonne Lee, Timmy Chi Wing Chan, Michael G Irwin, Chi Wai Cheung, Medicine. 2015, 2015 (in press).

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

Wong S.C.S. and Irwin M.G., Anaesthesia for fractured neck femur, Anaesthesia & Intensive Care Medicine. 2015, 16: 103-107.

Wong S.C.S. and Irwin M.G., Peri-operative cardiac protection for non-cardiac surgery, Anaesthesia. 2016, 71: 29-39.

Researcher : Wong TM

Project Title:	First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2000

Project Title:	Outstanding Research Student Supervisor Award 2001-2002
Investigator(s):	Wong TM
Department:	Anaesthesiology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	06/2002

Project Title:	XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2004

Project Title:	CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

List of Research Outputs

He S.F., Jin S.Y., Wu H., Wang B., Wu Y.X., Zhang S.J., Irwin M.G., Wong T.M. and Zhang Y., Morphine preconditioning confers cardioprotection in doxorubicine-induced failing rat hearts via ERK/GSK3b pathway independent of P13K/Akt., Toxicol appl Pharmacol. 2015, 288(3): 349-358.

Researcher : Xia Z

Project Title:	Nitrate tolerance compromises propofol protection of the endothelium against inflammation: The role of PKC-beta2 and NADPH oxidase interaction
Investigator(s):	Xia Z
Department:	Anaesthesiology
Source(s) of Funding:	SCA Research Starter and MidCareer Grants
Start Date:	07/2008

Project Title:	PKC-β2 through downregulating Caveolin-3 increases diabetic heart vulnerability to ischemia-reperfusion injury
Investigator(s):	Xia Z, Irwin MG, Vanhoutte PMGR
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	The role of FoxO1 in diabetic heart susceptibility to ischemia/reperfusion injury and sensitivity to ischemic postconditioning and its interplay with adiponectin
Investigator(s):	Xia Z, Vanhoutte PMGR, Xu A, Irwin MG
Department:	Anaesthesiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014

Project Title:	Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Normal and Diabetic rodents and its interplay with STAT3
Investigator(s):	Xia Z, Irwin MG, Wong GTC, Xu A, Wang JJ
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Experimental Biology 2015; Dexmedetomidine enhances cerebral cortex GIRK1 protein expression and attenuates Acute Postoperative Pain in rats.
Investigator(s):	Xia Z
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

Project Title:	Sevoflurance cardiopulmonary protection and mechanism
Investigator(s):	Xia Z
Department:	Anaesthesiology
Source(s) of Funding:	The First Hospital of Jilin University
Start Date:	08/2015

Project Title:	PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy
Investigator(s):	Xia Z, Xu A, Vanhoutte PMGR, Wang JJ, Irwin MG
Department:	Anaesthesiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	PKCε over-activation by down-regulating caveolin-3 compromises adiponectin-mediated ischemic postconditioning cardioprotection in diabetes
Investigator(s):	Xia Z, Irwin MG, Vanhoutte PMGR, Xu A
Department:	Anaesthesiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	SCA (Society of Cardiovascular Anesthesiologists) Annual Meeting 2016; Propofol Confers Postconditioning Cardioprotection Against Myocardial Ischemia Reperfusion Injury Via Modulation Of Caveolin1/endothelial Nitric Oxide Synthase Interaction
Investigator(s):	Xia Z
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

CHENG Y., Xia Z., Han Y. and Rong J., Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3 β Phosphorylation , Oxidative Medicine and Cellular Longevity. 2016, 2016: 1-11.

CHENG Y., Tse H.F., Xia Z. and Rong J., Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction: a possible role for leukotriene B4-12-hydroxydehydrogenase?, The 11th International Postgraduate Symposium on Chinese Medicine, Hong Kong Convention and Exhibition Center, Hong Kong, August 15, 2015.

Cao S., Liu Y., Wang H., MAO X., Chen J., Liu J., Xia Z., Zhang L., Liu X. and YU T., Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts, PeerJ. 2016, 4: e1706.

Chi X., Yao W., Zhang A., Ge M., Cai J., Zhou S., Xia Z., Luo G. and Hei Z., Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion, Mediators of Inflammation. 2015, 2015: 1-12.

Gan X., Xing D., Su G., Li S., Luo G., Irwin M.G., Xia Z., LI H. and Hei Z., Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation, Oxidative Medicine and Cellular Longevity. 2015, 2015: 1-15.

Gao S., Yang Z., Shi R., Xu D., Li H., Xia Z., Wu Q., Yao S., Wang T. and Yuan S., Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling, Eur J Pharmacol. 2016, 779: 111-21.

Gao S., Zhu Y., Li H., Xia Z., Wu Q., Yao S. and Wang T., Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation, Int Immunopharmacol. 2016, 38: 395-401.

Han X., Yao W., LIU Z., Li H., Zhang Z., Hei Z. and Xia Z., Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner, Oxid Med Cell Longev . 2016, 2016: 9303606.

KANDULA V., Kosuru R., Li H., YAN D., Zhu Q., Lian Q., Ge R., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetiol . 2016, 15: 44.

LUO X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. , In: Xin Luo, Xiaoming Amy Wang, Zhengyuan Xia, Sookja Kim Chung and Chi Wai Cheung, Review in Neurosciences. 2015, 27(1): 83-92.

Li H., Irwin M.G. and Xia Z., Caveolin-3/AdipoR1 dependent mitochondrial STAT3 activation in ischemic postconditioning cardioprotection in diabetes, The 18th South China International Congress of Cardiology. 2016.

Li H., Yao W., LIU Z., Wang S., Irwin M.G. and Xia Z., Diabetes abrogates the cardioprotective effects of ischemic postconditioning by impairing AdipoR1/Caveolin-3/STAT3 signaling, American Heart Association Scientific Sessions. 2015.

Li H., Yao W., LIU Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats, Diabetes. 2016, 65: 942-955.

Li H., WANG C., Chen C., Irwin M.G. and Xia Z., Repeated non-invasive limb ischemic preconditioning confers cardioprotection in diabetes by reducing necroptosis through STAT3 activation that is PKCɛ/Caveolin-3 dependent, Experimental Biology. 2016.

Li H., Irwin M.G. and Xia Z., Role and Mechanism of Adiponectin in Ischemic Postconditioning Cardioprotection: The Importance of AdipoR1/Caveolin-3-dependent STAT3 Activation, The 1st Annual Meeting of the Chinese Society of Cardiothoracic and Vascular Anesthesiology/ 10th International Chinese Cardiovascular Anesthesia Forum. 2015.

Li M.J., Liu Z., Wang P., Wong M.P., Nelson M., Kocher J.P.A., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J., GWASdb v2: an update database for human genetic variants identified by genome-wide association studies, Nucleic Acids Research. 2016, 44: D869-D876.

Li S., Xu J., Yao W., Li H., Liu Q., Xiao F., Irwin M.G., Xia Z. and Ruan W., Sevoflurane pretreatment attenuates TNF-a-induced human endothelial cell dysfunction through activating eNOS/NO pathway, Biochem Biophys Res Commun. 2015, 460(3): 879-886.

Lin J., Wang T., Li Y., Wang M., Li H., Xia Z. and Irwin M.G., N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats, J Diabetes Res . 2016, 2016: 9213034.

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016.

Pang L., Cai Y., Ma H., Irwin M.G. and Xia Z., Inhibition of COX-2/PGE2/EP4 signaling protects against cell apoptosis during hypoxia/reoxygenation in H9C2 cardiomyocytes, Experimental Biology 2016.

Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z., Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy, Journal of Diabetes Research. 2016, 2016: 1-10.

Qiao S., MAO X., WANG Y., Lei S., LIU Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats, Critical Care Medicine. 2016, 44: e131-e145.

Qiao S., MAO X., WANG Y., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the Janus activated kinase-2/Signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3b in rats, Crit Car Med. 2016, 44(3):3: 131-145.

Tian Y., LI H., Liu P., Xu J.M., Irwin M.G., Xia Z. and Tian G., Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans, Mediators of Inflammation. 2015, 2015: 1-12.

WANG Y., LI H., Huang H., Liu S., MAO X., Wang S., Wong S.C.S., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clinical Science. 2016, 130: 801-812.

WANG Y., Li H., Huang H., Liu S., Irwin M.G. and Xia Z., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/STAT3 signaling, Clin Sci (Lond). 2016, 130: 801-12.

Wang D.L., Zhan L., Zhang J. and Xia Z., Nurses’ blame attributions towards different types of cancer: A cross-sectional study, International Journal of Nursing Studies. 2015, 52: 1600-1606.

Wang L., Wang T., Li H., Liu Q., Zhang Z., Xie W., Feng Y., Socorburam T., Wu G. and Xia Z., Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice, PloS One. 2016, 11(5): e0155723.

Xia R., Xu J., Yin H., Wu H.Z., Xia Z., Zuo D., Xia Z.Y., Zhang L.P., LI H. and Xiao X., Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients, Mediators of Inflammation. 2015, 2015: 1-7.

Xia Z., Chinese Society of Anesthesiology (CSA), Challenges and progress of myocardial protection in diabetes patients. 2015.

Xia Z., Chinese Society of Anesthesiology (CSA), Pharmacology and Mechanism of Remifentanil induced cardioprotection and hyperalgesia. 2015.

Xia Z., Editorial Board Member, Frontiers in Medicine. 2016.

Xia Z., Editorial Board Member, Liver Research. 2016.

Xia Z., Executive Editor, Journal of Diabetes & Metabolism. 2016.

Xia Z., Guest Editor, Journal of Diabetes Research. 2016.

Xia Z., Ischemic Preconditioning for cardiac and neuronal protection during surgery, 2015 Guangzhou Medial University Anesthesiology Forum. 2015.

Xia Z., Journal Reviewer for research paper, Diabetes. 2015.

Xia Z., Myocardial Ischemia-reperfusion injury: Perioperative application of Danshen and Shen-fu preparations , Chinese Society of Integrated Anesthesiology. 2016.

Xia Z., Opioid Mediated Cardioprotection and hyperalgesia after cardiac surgery, The 3rd Sino-China Anesthesia Quality Control Expert Symposium (Hangzhou, China, Sept. 9, 2015). 2015.

Xia Z., Opioid mediated cardioprotection and hyperalgesia after cardiac surgery: Its mechanism and prevention, 2015 Hunan Provincial Anesthesiologist Society Annual Meeting, Hunan, China. 2015.

Xia Z., Chen Y., Fan Q., Xue M.Z. and Liu K.X., Oxidative Stress-Mediated Reperfusion Injury 2014, Oxidative Medicine and Cellular Longevity. 2015, 2015: 1-2.

Xia Z., Peer Reviewer for Journal (reviewed 3 papers in 2016), Plos ONE. 2016.

Xia Z., Peer Reviewer for Journal, Journal of Cardiovascular Pharmacology (reviewed 2 papers in 2016). 2016.

Xia Z., Peer Reviewer for journal, Biochemical Pharmacology. 2016.

Xia Z., Peer Reviewer for journal, J of Cellular and Molecular Medicine (1 paper reviewed). 2015.

Xia Z., Peer reviewer for academic journal, PLOS ONE (reviewed 4 papers in 2016). 2016.

Xia Z., Peer reviewer for journal "Diabetes", Diabetes. 2016.

Xia Z., Peer reviewer for journal (Am J Physiol), 2 papers reviewed, Am Journal of Physiology. 2015.

Xia Z., Peer reviewer for journal (J Surg Res, reviewed 2 papers), Journal of Surgical Research. 2015.

Xia Z., Peer reviewer for journal (J of Cellular and Molecular Medicine, reviewed 1 paper), Journal of Cellular and Molecular Medicine, reviewed 1 paper). 2015.

Xia Z., Peer reviewer for journal (Mediators of Inflammation, reviewed 3 papers), Mediators of Inflammation. 2015.

Xia Z., Remote ischemic preconditioning and its perioperative application, 2016 Congress of Chinese Society of Anesthesiologists. 2016.

Xia Z., The 5th Guangdong-Hong Kong/Taiwan Anesthesiology Meeting and 2015 Guangdong Anesthesia Society Meeting, Strategies to protect functionally impaired diabetic hearts. 2015.

Xia Z., Translational research for anesthetic organ protection, Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Anesthesia Research Symposium (Sept 10, 2015) . 2015.

Xia Z., Yichang District Anesthesiologist Annual Meeting, Yichang, Hubei, Synergy of isoflurane and propofol cardioprotection in cardiac surgery patients. 2015.

Xue R., Lei S., Xia Z., Wu Y., Meng Q., Zhan L., Su W., Liu H., Xu J., Liu Z., Zhou B. and Xia Z., Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways, Clinical Science. 2016, 130: 377-392.

Yao H., Chi X., Jin Y., Wang Y., Huang P., Wu S., Xia Z. and Cai J., Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats, Scientific Reports. 2015, 5: 16849.

Ye X., He Y., Xia Z. and Wang S., Fetal descending aortic flow and heart rate monitoring with transesophageal echocardiography during maternal cardiac surgery, Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 2016, 63: 492-494.

Yu H.P., Chaudry I.H., Choudhry M.A., Hsing C.H., Liu F.C. and Xia Z., Inflammatory Response to Traumatic Injury: Clinical and Animal Researches in Inflammation., Mediators of Inflammation. 2015, 2015;: 729637.

Yu X., Chi X., Wu S., Jin Y., Yao H., Wang Y., Xia Z. and Cai J., Dexmedetomidine Pretreatment Attenuates Kidney Injury and Oxidative Stress during Orthotopic Autologous Liver Transplantation in Rats, Oxidative Medicine and Cellular Longevity. 2015, 2016: 1-10.

Zhao W., Liu Z., Yu X., Lai L., Li H., LIU Z., Li L., Jiang S., Xia Z. and Xu S., iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways, Proteomics. 2015, 16: 564-75.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Zhuang H., Tian W., Li W., Zhang X., Wang J., Yang Y., Liu X., Xia Z., Feng D. and Zhang L., Autophagic Cell Death and Apoptosis Jointly Mediate Cisatracurium Besylate-Induced Cell Injury, International Journal of Molecular Sciences. 2016, 17: 515.

Researcher : Xiao F

List of Research Outputs

Li S., Xu J., Yao W., Li H., Liu Q., Xiao F., Irwin M.G., Xia Z. and Ruan W., Sevoflurane pretreatment attenuates TNF-a-induced human endothelial cell dysfunction through activating eNOS/NO pathway, Biochem Biophys Res Commun. 2015, 460(3): 879-886.

Researcher : Xu J

List of Research Outputs

Xia R., Xu J., Yin H., Wu H.Z., Xia Z., Zuo D., Xia Z.Y., Zhang L.P., LI H. and Xiao X., Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients, Mediators of Inflammation. 2015, 2015: 1-7.

Xue R., Lei S., Xia Z., Wu Y., Meng Q., Zhan L., Su W., Liu H., Xu J., Liu Z., Zhou B. and Xia Z., Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways, Clinical Science. 2016, 130: 377-392.

Researcher : YAN D

List of Research Outputs

KANDULA V., Kosuru R., Li H., YAN D., Zhu Q., Lian Q., Ge R., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetiol . 2016, 15: 44.

Researcher : Yao W

List of Research Outputs

Chi X., Yao W., Zhang A., Ge M., Cai J., Zhou S., Xia Z., Luo G. and Hei Z., Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion, Mediators of Inflammation. 2015, 2015: 1-12.

Researcher : Yuen VMY

Project Title:	Comparison of oral chloral hydrate and intranasal dexmedetomidine for sedation in children undergoing computerised tomography in Queen Mary Hospital
Investigator(s):	Yuen VMY, Hui TWC, Wong ICK, Irwin MG
Department:	Anaesthesiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

List of Research Outputs

Li B.L., Zhang N., Huang J.X., QIU Q., Tian H., Ni J., Song X.R., Yuen V.M.Y. and Irwin M.G., A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops, Anaesthesia. 2016, 71(5): 522-528.

Researcher : Zhang Y

List of Research Outputs

He S.F., Jin S.Y., Wu H., Wang B., Wu Y.X., Zhang S.J., Irwin M.G., Wong T.M. and Zhang Y., Morphine preconditioning confers cardioprotection in doxorubicine-induced failing rat hearts via ERK/GSK3b pathway independent of P13K/Akt., Toxicol appl Pharmacol. 2015, 288(3): 349-358.

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