Dept of Medicine

DEPT OF MEDICINE

Researcher : Au KW

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Researcher : Bow HYC

List of Research Outputs

Samartzis D., Borthakur A., Belfer I., Bow H.Y.C., Lotz J.C., Wang H., Cheung K.M.C., Carragee E. and Karppinen J.I., Novel diagnostic and therapeutic methods for intervertebral disc degeneration and low back pain, Spine J. 2015, 1919-1932.

Researcher : Bu L

Project Title:	Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):	Bu L, Li RA
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2012

Researcher : CHAN KW

List of Research Outputs

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Researcher : CHAU HWD

List of Research Outputs

CHAU H.W.D., NG K., Chan S.Y.T., Cheng Y.Y., Fong B., Tam S., Kwong Y.L. and Tse E.W.C., Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9, Journal of Hematology & Oncology. 2015, 8.

Researcher : CHEN Y

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : CHIU SM

List of Research Outputs

Sun Y., Zhang Y., Li X., Deng M., Gao W., Yao Y., CHIU S.M., LIANG X., GAO F., Chan C.W.Y., Tse H.F., Shi J., Fu Q. and Lian Q., Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice, STEM CELLS. 2015, n/a-n/a.

Zhang Y., CHIU S.M., LIANG X., GAO F., ZHANG Z., Liao S., LIANG Y., Low D. .J. .H., Tse H.F., Lian Q. and Tergaonkar V., Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction, CELL DEATH DISCOVERY. 2015.

Researcher : CHOI MYO

List of Research Outputs

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Researcher : CHONG CK

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Researcher : CUI Y

List of Research Outputs

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). ATS, 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The Presence Of Serotonin In Cigarette Smoke - A Possible Mechanism In Cigarette Smoke-Induced Airway Inflammation, Am J Respir Crit Care Med . 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanism in cigarette smoke-induced airway inflammation, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 21.

Lau K.W., CUI Y., Chan C.H., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation, Free Radical Research. 2016, 50: 495-502.

Liu W.K.K., CUI Y., Liang Y., Ip M.S.M. and Mak J.C.W., Age difference in responses to cigarette smoke-induced injury in a rat model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 41.

Researcher : Chan AOO

List of Research Outputs

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Researcher : Chan CYJ

List of Research Outputs

Chan C.Y.J., Advances in Therapies of Psoriasis, Annual Scientific Meeting 2015; Hong Kong Woman Doctors' Association. 2015.

Chan C.Y.J., Approaches to treatment-refractory seborrheic dermatitis, Asia Pacific Dermatitis Leaders’ Summit 2015. 2015.

SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern Chinese., Presented at the ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015.

SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern chinese, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2016. 2015.

Researcher : Chan DTM

Project Title:	Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	The Role of Annexin II in the Regulation of Inflammation and Fibrosis in Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Gut Microbiota Products in the Pathogenesis of Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY, Yap YHD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

Project Title:	The Role of CD44 in the Pathogenesis of Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	The role of hepatocyte growth factor in lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	The role of Ku70 and Ku80 in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Measurement of inflammatory and fibrotic mediators in serum and their association with vascular injury in patients with lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015

Project Title:	The Role of Major Vault Protein in Tubulo-interstitial Injury during Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	ASN Kidney Week 2015 Annual Meeting; Serum Acetate and Lipopolysaccharide Levels Correlate with Disease Activity in Patients with Lupus Nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015

Project Title:	The roles of lipopolysaccharide, lipopolysaccharide binding protein and CD14 in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	The role of lysophosphatidic acid in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

List of Research Outputs

Besarab A., Chernyavskaya E., Motylev I., Shutov E., Kumbar L.M., Gurevich K., Chan D.T.M., Leong R., Poole L., Zhong M., Saikali K.G., Franco M., Hemmerich S., Yu K.H.P. and Neff T.B., Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients, Journal of the American Society of Nephrology. 2016, 27(4): 1225-1233.

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Chan K.Y., Yip T., Yap Y.H.D., Sham M.K., Wong Y.C., Lau W.K., Li C.W., Cheng H.W., Lo W.K. and Chan D.T.M., Enhanced Psychosocial Support for Caregiver Burden for Patients With Chronic Kidney Failure Choosing Not to Be Treated by Dialysis or Transplantation: A Pilot Randomized Controlled Trial, American Journal of Kidney Diseases. 2016, 67(4): 585-92.

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Lam K.S.L., Chow C.C., Tan K.C.B., Ma R.C., Kong A.P., Tong P.C., Tsang M.W., Chan D.T.M., Tang S.C.W., Lee K.K., So W.Y. and Tomlinson B., Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes, Current Medical Research and Opinion. 2016, 32: 1097-1108.

Liao J., Liu Y., Wu H., Zhao M., Tan Y., Li D., Long H., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q.J., The role of icaritin in regulating Foxp3/IL17a balance in systemic lupus erythematosus and its effects on the treatment of MRL/lpr mice, Clinical Immunology. 2016, 162: 74-83.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Sham H.P., Kong H.H.Y., Chan K.C., Yan W.W. and Chan D.T.M., Septic acute kidney injury in critically ill patients – a single-center study on its incidence, clinical characteristics, and outcome predictors, Renal Failure. 2016, 38(5): 706-716.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Shun H.P., Yan W.W. and Chan D.T.M., Recent knowledge on the pathophysiology of septic acute kidney injury: A narrative review, Journal of Critical Care. 2016, 31(1): 82-89.

Tang Q., Yang Y., Zhao M., Liang G., Wu H., Liu Q., Xie Y., Li D., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., Mycophenolic acid upregulates miR-142-3P/5P and miR-146a in lupus CD4+T cells, Lupus. 2015, 24: 935-942.

Yap Y.H.D., Tse H., Mok M.M., Chan G.C., Yip T., Lui S.L., Lo W.K. and Chan D.T.M., Arthrobacter sanguinis: an uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2015, 20(11): 868.

Yap Y.H.D., Mok M.M., Chan G.C., Choy B.Y. and Chan D.T.M., Kidney Allograft Abscess: An Unusual Cause of Peritonitis in a Patient on Peritoneal Dialysis, Nephrology (Carlton). 2016, 21(3): 266.

Yap Y.H.D. and Chan D.T.M., Lupus Nephritis in Asia: Clinical Features and Management, Kidney Diseases. 2015, 1(2): 100-109.

Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang C. and Chan D.T.M., Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis, Lupus. 2016, 25(1): 46-53.

Yap Y.H.D. and Chan D.T.M., Use of telbivudine in kidney transplant recipients with chronic hepatitis B virus infection: A preliminary experience., Nephrology (Carlton). 2016, 21(5): 438-41.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yung S.S.Y. and Chan D.T.M., Mechanisms of Kidney Injury in Lupus Nephritis - the Role of Anti-dsDNA Antibodies, Frontiers in Immunology. 2015, 6.

Yung S.S.Y. and Chan D.T.M., Molecular and Immunological Basis of Tubulo-Interstitial Injury in Lupus Nephritis: a Comprehensive Review, Clinical Reviews in Allergy & Immunology. 2016.

Yung S.S.Y., LI N., Chau K.M., Kam K.M. and Chan D.T.M., Peritonitis induces native and EDA+ fibronectin synthesis in human peritoneal mesothelial cells through PI3K and MAPK activation, ASN Kidney Week 2015.

ZHANG J., ZHANG L., ZHANG Y., Yang J., GUO M., Sun L., Pan H.F., Hirankarn N., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W.G., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong W.S.R., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Cui Y., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations , Arthritis & Rheumatology. 2015, 67(11): 2966-77.

Researcher : Chan GCW

List of Research Outputs

Chan G.C.W. and Tang S.C.W., Diabetic Nephropathy: Landmark: clinical trials and tribulations, Nephrol Dial Transplant. 2016, 31: 359-368.

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Tang S.C.W., Chan G.C.W. and Lai K.N., Recent advances in managing and understanding diabetic nephropathy, F1000Research. 2016, 5: 1044.

Researcher : Chan GCW

List of Research Outputs

Chan G.C.W. and Tang S.C.W., Diabetic Nephropathy: Landmark: clinical trials and tribulations, Nephrol Dial Transplant. 2016, 31: 359-368.

Tang S.C.W., Chan G.C.W. and Lai K.N., Recent advances in managing and understanding diabetic nephropathy, F1000Research. 2016, 5: 1044.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Chan HHL, Lam LK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2000

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Chan HHL, Wei WI
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	11/2001

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Chan JCK, Lam WK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	07/1995

Researcher : Chan KH

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, APAC MS Summit 2015.

Chan K.H., Guillain-Barre Syndrome, Annual Neurology Conference, HKU-Shenzhen Hospital. 2015.

Chan K.H., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Ng C.L., Novel manifestations of anti-myelin–associated glycoprotein (MAG) antibodies neuropathy, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 11.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Lam C.L.D., Luo Y., Fu K.H., Lui M.M.S., Chan K.H., Wistuba I.I., Gao B., Tsao G.S.W., Ip M.S.M. and Minna J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310: L232-L239.

Lee C.Y., Lam C.L.D., Pang S.Y.Y., Lau G.K.K., Teo K.C., Chang S.K.R. and Chan K.H., Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese, Journal of Neuroimmunology. 2015, 289: 177-181.

Leung S.T.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Chan K.H., Efficacy of beta-interferon in relapsing multiple sclerosis among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 36.

Researcher : Chan KH

Project Title:	Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	01/2008

Project Title:	Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):	Chan KH, Ho SL
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	03/2008

Project Title:	The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):	Chan KH, Ho WL
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	04/2009

Project Title:	Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):	Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2010

Project Title:	Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):	Chan KH, Ho WL
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	06/2011

Project Title:	Adiponectin gene therapy in mouse model of Alzheimer’s disease (CRF)
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015

List of Research Outputs

Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, APAC MS Summit 2015.

Chan K.H., Guillain-Barre Syndrome, Annual Neurology Conference, HKU-Shenzhen Hospital. 2015.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan MMW

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2001

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Researcher : Chan P

List of Research Outputs

Lam C.L.K., Law W.L., Poon T.C.J., Chan P., Wong C.K.H., McGhee S. and Fong D.Y.T., Health-related quality of life in patients with colorectal neoplasm and cost-effectiveness of colorectal cancer screening in Hong Kong, Hong Kong Medical Journal. Hong Kong, Hong Kong Academy of Medicine, 2015, 21(Suppl 6): S4–8.

Researcher : Chan PHM

Project Title:	Left Atrial Volume by Computed Tomography in prediction of New onset Atrial Fibrillation
Investigator(s):	Chan PHM, Siu DCW, She HLH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease
Investigator(s):	Chan PHM, She HLH, Tse HF, Chan WS, Siu DCW, Cheung CWS
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management
Investigator(s):	Chan PHM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease
Investigator(s):	Chan PHM, Ng MY, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk
Investigator(s):	Chan PHM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

List of Research Outputs

Chan P.H.M., Advances in Hypertension and Heart Failure Management, The HKMA Yau Tsim Mong Community Network CME Lecture. 2015.

Chan P.H.M., Approach to specific coronary lesion - Thrombotic lesion (AMI), Transcatheter Therapeutics Course 2015. 2015.

Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Lip G.Y., Lam K.S.L., Tse H.F. and Siu D.C.W., Benefit of Anticoagulation Therapy in Hyperthyroidism-Related Atrial Fibrillation, Clin Cardiol. 2015, 38(8): 476-82.

Chan P.H.M., Lau C.P., Tse H.F., Chiang C.E. and Siu D.C.W., CHA2DS2-VASc Recalibration With an Additional Age Category (50-64 Years) Enhances Stroke Risk Stratification in Chinese Patients With Atrial Fibrillation, Canadian Journal of Cardiology. 2016.

Chan P.H.M. and Siu D.C.W., Clinical Benefit of Warfarin in Dialysis Patients With Atrial Fibrillation, J Am Coll Cardiol. 2015, 66(11): 1310-1.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Chan P.H.M., Left main intervention, Cardiovascular Interventional Summit 2015. 2015.

Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016.

Chan P.H.M., Real world experience of SPAF management in Hong Kong, 3rd TCM SPAF Academy. 2016.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Chan P.H.M., Tackling Atrial Fibrillation at the Population Level, 19th Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine (ICSM). 2015.

Chan P.H.M., The Role of Aquaresis in Heart Failure, Hong Kong Pharmacy Conference 2016. 2016.

Chan P.H.M., The Role of Aquaresis in Heart Failure, Macau Cardiology Association Annual General Assembly 2015. 2015.

Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015.

Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

Huang D., Chan P.H.M., Lam C.C., Shea P.C., Yiu K.H., Tse H.F. and Siu D.C.W., Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction, J Heart Valve Dis. 2015, 24(4): 433-5.

Loh P.H., Bourantas C.V., Chan P.H.M., Ihlemann N., Gustafsson F., Clark A.L., Price S., Mario C.D., Moat N., Alamgir F., Estevez-Loureiro R., Sondergaard L. and Franzen O., Catheter-based intervention for symptomatic patient with severe mitral regurgitation and very poor left ventricular systolic function - Safe but no room for complacency, World J Cardiol. 2015, 7(11): 817-21.

Researcher : Chan PL

List of Research Outputs

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Researcher : Chan SYT

List of Research Outputs

CHAU H.W.D., NG K., Chan S.Y.T., Cheng Y.Y., Fong B., Tam S., Kwong Y.L. and Tse E.W.C., Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9, Journal of Hematology & Oncology. 2015, 8.

Chan S.Y.T., Marcella S.W., Singh G.H.H., Hwang Y.Y.G. and Kwong Y.L., Posaconazole versus fluconazole or itraconazole for prevention of invasive fungal diseases in patients with acute myeloid leukemia or myelodysplastic syndrome: a cost-effectiveness analysis in an Asian teaching hospital, Journal of Medical Economics. 2015, 1-22.

Iu L.P.L., Fan C.Y., Lau K.P., Chan S.Y.T., Kwong Y.L. and Wong Y.H.I., Long-term Follow-up of Cytomegalovirus Retinitis in Non-HIV Immunocompromised Patients: Clinical Features and Visual Prognosis, American Journal of Ophthalmology. 2016, 165: 145-153.

Marinelli M., Ilari I., Xia Y., Giudice I.D., Cafforio L., Starza I.D., Raponi S., Mariglia P., Bonina S., YU Z., YANG W., QIU L., Chan S.Y.T., Piciocchi A., Kwong Y.L., Tse E.W.C., Li J., Guarini A., XU W. and Foà R., Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia, Oncotarget. 2016.

Researcher : Chan TCI

List of Research Outputs

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Researcher : Chan VNY

Project Title:	Hepatitis B virus array for genotyping and mutation detection
Investigator(s):	Chan VNY, Lai CL, Chan K, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2006

Researcher : Chan VSF

Project Title:	Proteomic analysis of CLEC16A interacting partners in autophagy
Investigator(s):	Chan VSF, Tam CY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	A study of interferon-induced chemokines signature in lupus nephritis development
Investigator(s):	Chan VSF, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chan V.S.F., Editorial Board Member, International Journal of Molecular Sciences. Basel, Switzerland, MPDI AG, 2016, Molecular Diagnostics.

LEUNG W.H., Lau B.W.M., Chan V.S.F., Lau W.C.S. and So K.F., Abnormal increase of neuronal precursor cells and exacerbated neuroinflammation in the corpus callosum in murine model of systemic lupus erythematosus, Restorative Neurology and Neuroscience. 2016, 34: 443-453.

Researcher : Chan WK

List of Research Outputs

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. Annual Scientific meeting of the American College of Rheumatology 2015. Arthritis Rheum 2015, 2015.

Researcher : Chan WS

List of Research Outputs

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : Chan YCC

List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Researcher : Chan YY

List of Research Outputs

Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Tang S.C.W. and Lai K.N., Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells, Apoptosis [IF 3.614]. 2015, 20(7): 907-920.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Chang SKR

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Chan K.H., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Ng C.L., Novel manifestations of anti-myelin–associated glycoprotein (MAG) antibodies neuropathy, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 11.

Ho S.L., Chang S.K.R., Pang S.Y.Y., Li L.S.W., Chen J. and Lee M.C., Visual motor control in patients with Parkinson's disease., Journal of Vision. United States, Association for Research in Vision and Ophthalmology, 2015, 15(12): 593.

Lee C.Y., Lam C.L.D., Pang S.Y.Y., Lau G.K.K., Teo K.C., Chang S.K.R. and Chan K.H., Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese, Journal of Neuroimmunology. 2015, 289: 177-181.

Leung S.T.S., Lee J.C.Y., Lau G.K.K., Chang S.K.R., Pang S.Y.Y. and Ng C.L., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 37.

Leung S.T.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Chan K.H., Efficacy of beta-interferon in relapsing multiple sclerosis among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 36.

YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Inhibition Impairments in Temporal Lobe Epilepsy (TLE) Patients: Electroencephalography (EEG) Evidence from a Go/Nogo Study, 21st Medical Research Conference (HKU) . 2016, 60.

Researcher : Chau KM

List of Research Outputs

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Yung S.S.Y., LI N., Chau K.M., Kam K.M. and Chan D.T.M., Peritonitis induces native and EDA+ fibronectin synthesis in human peritoneal mesothelial cells through PI3K and MAPK activation, ASN Kidney Week 2015.

Researcher : Chau WK

List of Research Outputs

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

Researcher : Chen WH

Project Title:	Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2001

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Researcher : Cheng CW

Project Title:	Role of PIN1 in the promotion of DNA double-strand break repair through interaction with ATM protein
Investigator(s):	Cheng CW, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014
Completion Date:	05/2016

Researcher : Cheng CYS

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Researcher : Cheng KY

Project Title:	The role of hypothalamic APPL2 in energy metabolism
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	The adaptor protein APPL2 as a physiological modulator of pancreatic β-cell functions in mice
Investigator(s):	Cheng KY, Cheung YY
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	The MDM2-p53 pathway as a novel regulator of glucose-stimulated insulin secretion in pancreatic beta cells
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in adipose tissues
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	APPL2 as a key mediator of white-to-beige fat transdifferentiation
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	The novel role of hematopoietic APPL1 in regulating adipose tissue inflammation and insulin resistance in obesity
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	The role of adipocyte turnover in regulation of systemic energy and glucose homeostasis
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Researcher : Cheng YY

Project Title:	The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):	Cheng YY, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008

Researcher : Cheung AJ

List of Research Outputs

Cheung A.J. and Cheung B.M.Y., Association of increased systolic blood pressure in children with obesity and the metabolic syndrome., Presented at the British Hypertension Society Annual Scientific Meeting 2015, Stratford-upon-Avon, England. 2015.

Cheung A.J. and Cheung B.M.Y., Association of increased systolic blood pressure in children with obesity and the metabolic syndrome, Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

Cheung A.J. and Cheung B.M.Y., Systolic blood pressure is strongly related to body weight in children., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population 1999-2012., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the Symposium on Environmental Health and Food Safety, University of Hong Kong, 2016.

TSOI M.F., Cheung A.J., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Decrease in blood lead level in the United States Population: United States National Health Nutrition and Examination Survey (NHANES) 1999-2014., Presented at the11th International Symposium on Healthy Aging 2016, Hong Kong. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Fall in blood lead level in the US population 1999-2012., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 122.

Researcher : Cheung BMY

Project Title:	Does an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?
Investigator(s):	Cheung BMY, Lam KSL, Tse HF, Wang Y
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012
Completion Date:	09/2015

Project Title:	Accelerating the Development of Pharmacogenomics at HKU through a Systems Biology Approach
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Innovative Research Grants
Start Date:	07/2013

Project Title:	The pharmacoepidemiology of serious adverse drug reactions due to colchicine in Hong Kong
Investigator(s):	Cheung BMY, Cheung CL, Wong ICK, Lam MPS, Hung FNI, Cheung TT
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Use of medications for osteoporosis in Hong Kong
Investigator(s):	Cheung BMY, Cheung CL, Cheung TT, Woo YC
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Cheung A.J. and Cheung B.M.Y., Association of increased systolic blood pressure in children with obesity and the metabolic syndrome., Presented at the British Hypertension Society Annual Scientific Meeting 2015, Stratford-upon-Avon, England. 2015.

Cheung A.J. and Cheung B.M.Y., Association of increased systolic blood pressure in children with obesity and the metabolic syndrome, Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

Cheung A.J. and Cheung B.M.Y., Systolic blood pressure is strongly related to body weight in children., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

Cheung B.M.Y., Evolution of the Postgraduate Medical Journal , Postgraduate Medical Journal. 2015, 91: 539-539.

Cheung B.M.Y., Woo Y.C., Fong C.H.Y., Xu A. and Lam K.S.L., Blood level of fibroblast growth factor 21 and blood pressure. , Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

Cheung B.M.Y., Editor in Chief, Postgraduate Medical Journal. 2015.

Cheung B.M.Y., Editor-in-Chief, World Journal of Diabetes (1 Jan 2016 to 31 Dec 2019). 2016.

Cheung B.M.Y., Specialty Programme Director in the Subcommittee in Clinical Pharmacology & Therapeutics, Hong Kong College of Physicians. 2015.

Cheung B.M.Y., What is clinical pharmacology?, Medical Diary. 2016, 21(2): 6-7.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed only in the presence of peripheral vascular disease., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed when peripheral artery disease is present, Journal of Diabetes and its Complications. 2015, 30: 306-11.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of Cutpoints for Low Lean Mass and Slow Gait Speed in Predicting Death in the National Health and Nutrition Examination Survey 1999-2004, J Gerontol A Biol Sci Med Sci.. 2016, 71: 90-5.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17.

Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61.

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94.

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18.

Cheung C.L. and Cheung B.M.Y., Relationship between serum beta-2-microglobulin and cardiovascular risk factors., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18.

Cheung C.L. and Cheung B.M.Y., Relationship between serum beta-2-microglobulin and cardiovascular risk factors., Presented at the European Society of Cardiology Congress 2015, London. 2015.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Compliance of disease modifying anti-rheumatic drugs in rheumatoid arthritis patients: a longitudinal study., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF-alpha inhibitor on subclinical atherosclerosis in rheumatoid arthritis patients: a meta-analysis., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury due to cosmetic cream in Hong Kong: a retrospective case series., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 21.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 24th Annual Scientific Congress of the Hong Kong College of Cardiology. J Hong Kong Coll Cardiol 2016. 24: 26.

FU S.N. and Cheung B.M.Y., Psychological insulin resistance among older patients with type 2 diabetes mellitus., Presented at 5th Asia Pacific Primary Care Research Conference, Putrajaya, Malaysia 2015.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in Prescriptions for Osteoporosis and Reduction in Hip Fracture Incidence in Hong Kong 2005-2014., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 25.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in prescriptions for osteoporosis and reduction in hip fracture incidence in Hong Kong 2005-2014., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Han Y., Leung Y.H., Cheung B.M.Y. and Cheung C.L., Relationship of serum vitamin D status and risk of stroke., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

Kumana C.R., Cheung B.M.Y., Siu D.C.W., Tse H.F. and Lauder I.J., Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights, Cardiovascular Therapeutics. 2016, 34: 100-106.

Kunutsor S.K., Apekey T.A. and Cheung B.M.Y., Gamma-glutamyltransferase and risk of hypertension, Journal of Hypertension. 2015, 33: 2373-2381.

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Prevalence of Potentially Inappropriate Prescribing Among Hong Kong Older Adults: A Comparison of the Beers 2003, Beers 2012, and Screening Tool of Older Person's Prescriptions and Screening Tool to Alert doctors to Right Treatment Criteria, Journal of the American Geriatrics Society . 2015, 63: 1471-2.

Lam M.P.S., Wong I.C.K. and Cheung B.M.Y., Using the prevalence of potentially inappropriate prescribing in Hong Kong as an example to illustrate the importance of content validation, 11th International Symposium on Healthy Aging, Hong Kong. 2016.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Leung Y.H., Cheung B.M.Y., Kung A.W.C., Tan K.C.B. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 35.

Leung Y.H., Cheung B.M.Y. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

Li X., Tse V.C., Lau C.Y., Cheung B.M.Y., Lip G.Y.H., Wong I.C.K. and Chan E.W., Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis., Plos One. 2016, 11(6): e0157129.

SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern Chinese., Presented at the ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2015.

SING C.W., Cheung B.M.Y., Wong I.C.K., Chan C.Y.J. and Cheung C.L., Epidemiological study of non-chemotherapy drug-induced agranulocytosis in southern chinese, The ISPE's 9th Asian Conference on Pharmacoepidemiology, Bangkok, Thailand, November 14-16, 2016. 2015.

SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54.

Samartzis D., Bow H.Y.C., Karppinen J., Luk K.D.K., Cheung B.M.Y. and Cheung K.M.C., Family history of low back pain is a significant predictor of pain and disability between extreme stages of lumbar disc degeneration, Spineweek 2016, Singapore, May 16-20, 2016.

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population 1999-2012., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the Symposium on Environmental Health and Food Safety, University of Hong Kong, 2016.

TSOI M.F., Cheung C.L., Cheung T.T. and Cheung B.M.Y., Continual Decrease in Blood Lead Level in Americans: United States National Health Nutrition and Examination Survey 1999-2014, The American Journal of Medicine. 2016.

TSOI M.F., Cheung A.J., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Decrease in blood lead level in the United States Population: United States National Health Nutrition and Examination Survey (NHANES) 1999-2014., Presented at the11th International Symposium on Healthy Aging 2016, Hong Kong. 2016.

TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Fall in blood lead level in the US population 1999-2012., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 122.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016.

YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016.

Researcher : Cheung CL

Project Title:	Epidemiological study of serious adverse drug reactions in Hong Kong
Investigator(s):	Cheung CL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	05/2016

Project Title:	Genetics and genomics of anti-thyroid drug induced agranulocytosis
Investigator(s):	Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study
Investigator(s):	Cheung CL, Tan KCB, Kung AWC, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

Project Title:	Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study
Investigator(s):	Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	American Society of Bone and Mineral Research (ASBMR) 2015 Annual Meeting; Evaluation of cutpoints for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2015
Completion Date:	10/2015

Project Title:	Precision Medicine of Osteoporosis Medication in Chinese (PreMOMiC): A retrospective and prospective pharmacogenomic study of denosumab
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Researcher : Cheung CYS

List of Research Outputs

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Researcher : Cheung KF

Project Title:	Serum levels and intra-renal expression of annexin II in patients and mice with lupus nephritis, and their correlation with disease activity
Investigator(s):	Cheung KF, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	11/2015

List of Research Outputs

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Cheung RTF

Project Title:	Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2005

Project Title:	Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

Project Title:	Adverse effects of up-regulated adiponectin level on immune system in mice stroke models. Part I: effects of exogenous PPARgamma antagonist (BADGE) in wide type and transgenic mice.
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2013

Project Title:	Neuroprotection of melatonin and calpeptin in a rat ischemic stroke model
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Cheung R.T.F., Associate Editor, Advances in Alzheimer's Disease. Scientific Research Publishing, 2016.

Cheung R.T.F., Editorial Board, Asian Journal of Neuroscience. Hindawi Publishing, 2016.

Cheung R.T.F., Editorial Board, Austin Journal of Anatomy. Austin Publishing Group, 2015.

Cheung R.T.F., Editorial Board, Austin Journal of Cerebrovascular Disease & Stroke. Austin Publishing Group, 2016.

Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2016.

Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2016.

Cheung R.T.F., Editorial Board, Edorium Journal of Neurology. Edorium Journal, 2016.

Cheung R.T.F., Editorial Board, JSM Ophthalmology. JSciMedCentral, 2016.

Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2016.

Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2016.

Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2016.

Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2016.

Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2016.

Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2016.

Cheung R.T.F., Editorial Board, World Journal of Biological Chemistry. Baishideng Publishing Group, 2016.

Cheung R.T.F., Honorary Editorial Advisory Board in Asia, MIMS Neurology & Psychiatry Guide Fifth Edition. 2015.

Cheung R.T.F., Journal editor, SM Journal of Neurology and Neuroscience. SM Group, 2016.

Cheung R.T.F., Laboratory Diagnosis in Neurological Problems, Module: Laboratory Diagnosis, Certificate Course of Primary Healthcare for Chinese Medicine Practitioners, Hong Kong Association for Integration of Chinese-Western Medicine. 2016.

Cheung R.T.F., Regional Editor, Cardiovascular & Hematological Agents in Medicinal Chemistry. Bentham Science Publishers, 2015.

Cheung R.T.F., one of six International Editors, In: Clarke C, Howard R, Rossor M, Shorvon S, Neurology – A Queen Square Textbook . Wiley-Blackwell, 2016, 1-1074.

Cheung R.T.F., 學生自殺個案急升, 希期創刊號：學生自殺, 2016, 1.

FENG Y. and Cheung R.T.F., Neuroprotection of melatonin and/or calpeptin in a rat experimental cerebral ischaemia and reperfusion model, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 22.

GAO Y., Cheung R.T.F., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok M.Y.T., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 56.

LEUNG W.H. and Cheung R.T.F., Potential use of melatonin as a therapy for intracerebral haemorrhage, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 34.

Li C.M., Yuan W.Z., Cheung R.T.F., Liu S.M. and Liu Z., Mainland medicine inspired by Hong Kong medicine from the view of clinical doctors, Modern Hospital Management. 2016, 14: 59-61.

YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Inhibition Impairments in Temporal Lobe Epilepsy (TLE) Patients: Electroencephalography (EEG) Evidence from a Go/Nogo Study, 21st Medical Research Conference (HKU) . 2016, 60.

Researcher : Cheung TT

Project Title:	Cost of illness of Ankylosing Spondylitis in Hong Kong
Investigator(s):	Cheung TT, Lau WCS, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Correlation of Fibroblast Growth Factor 21 (FGF21) with paracetamol levels in patients with paracetamol poisoning
Investigator(s):	Cheung TT, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Relationship between drug levels of tutor necrosis factor inhibitors and the clinical and radiological response in patients with axial spondyloarthritis
Investigator(s):	Cheung TT, Cheung BMY, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

List of Research Outputs

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Compliance of disease modifying anti-rheumatic drugs in rheumatoid arthritis patients: a longitudinal study., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF-alpha inhibitor on subclinical atherosclerosis in rheumatoid arthritis patients: a meta-analysis., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury due to cosmetic cream in Hong Kong: a retrospective case series., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 21.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 24th Annual Scientific Congress of the Hong Kong College of Cardiology. J Hong Kong Coll Cardiol 2016. 24: 26.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in Prescriptions for Osteoporosis and Reduction in Hip Fracture Incidence in Hong Kong 2005-2014., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 25.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in prescriptions for osteoporosis and reduction in hip fracture incidence in Hong Kong 2005-2014., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population 1999-2012., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the Symposium on Environmental Health and Food Safety, University of Hong Kong, 2016.

TSOI M.F., Cheung C.L., Cheung T.T. and Cheung B.M.Y., Continual Decrease in Blood Lead Level in Americans: United States National Health Nutrition and Examination Survey 1999-2014, The American Journal of Medicine. 2016.

TSOI M.F., Cheung A.J., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Decrease in blood lead level in the United States Population: United States National Health Nutrition and Examination Survey (NHANES) 1999-2014., Presented at the11th International Symposium on Healthy Aging 2016, Hong Kong. 2016.

TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Fall in blood lead level in the US population 1999-2012., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 122.

Researcher : Cheung YY

Project Title:	Causal effect of adiposity in diabetic retinopathy: a Mendelian randomisation analysis
Investigator(s):	Cheung YY, Lam KSL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	Impact of genetic variants identified in genome-wide association studies and their possible interaction with hypertension on the risk of diabetic retinopathy
Investigator(s):	Cheung YY, Lam KSL, Sham PC, Wong DSH, Gangwani RA, Yuen MAM
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Researcher : Chim JCS

Project Title:	FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Lee Hysan Foundation - General Award
Start Date:	07/2008

Project Title:	Study of methylation of microRNA in mantle cell lymphoma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012
Completion Date:	12/2015

Project Title:	Genetic study (FISH study) for personalized treatment of multiple myeloma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2012

Project Title:	Epigenetic silencing of tumour suppressor miR-212/132 cluster in Philadelphia-negative myeloproliferative neoplasm
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2013

Project Title:	Use of Bortezomib during conditioning of autologous stem cell transplantation of international stage III myeloma
Investigator(s):	Chim JCS, Kwong YL, Lie AKW
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2014

Project Title:	Epigenetic silencing of MIR-340 in haematological malignancies
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Mechanism study of the effect of microenviroment on RANKL expression in myeloma cells
Investigator(s):	Chim JCS, Wong KY
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chim J.C.S., American Journal of Molecular Biology, 2015.

Chim J.C.S., Austin Biomarkers & Diagnosis, 2015.

Chim J.C.S., Case Reports in Oncological Medicine . 2015.

Chim J.C.S., Clinical Epigenetics, 2015.

Chim J.C.S., Current Advances in Chemistry Research (CACR). 2015.

Chim J.C.S., Editor-in-Chief, Journal of Genetics Study . 2015.

Chim J.C.S., Epigenomics (impact factor:3.429), 2015.

Chim J.C.S., Frontiers in Epigenomics, 2015.

Chim J.C.S., Health (http://www.scirp.org/journal/health), 2015.

Chim J.C.S., International Journal of Advanced Chemistry Research (IJACR) . 2015.

Chim J.C.S., International Journal of Cancer Immunology & Immunotherapy. 2015.

Chim J.C.S., International Journal of Hematology Research (IJHR). 2015.

Chim J.C.S., Journal of Applied Scientific Reports . 2015.

Chim J.C.S., Journal of Cancer Metastasis and Treatment, 2015.

Chim J.C.S., Journal of cancer studies and therapy, 2015.

Chim J.C.S., Modern Chemotherapy . 2015.

Chim J.C.S., PLoS ONE (impact factor: 4.41), 2015.

Chim J.C.S., Senior Editor, Journal of Gene Therapy . 2015.

Chim J.C.S., The Hong Kong Medical Diary. 2016.

Chim J.C.S., The Open Access Journal of Science and Technology, 2015.

Chim J.C.S., The Open Leukemia Journal. 2015.

Chim J.C.S., The Open Pathology Journal. 2016.

Chim J.C.S., The Open Translational Medicine Journal. 2015.

Gupta N., Goh Y.T., Min C., Lee J.H., Kim K., Wong R.S.M., Chim J.C.S., Hanley M.J., Yang H., Venkatakrishnan K., Hui A., Esseltine D. and Chng W.J., Pharmacokinetics and safety of the proteasome inhibitor Ixazomib plus lenalidomide-dexamethasone in Asian patients with relapsed/refractory multiple myeloma, 2015.

Wong K.Y. and Chim J.C.S., DNA methylation of tumor suppressor protein-coding and non-coding genes in multiple myeloma, Epigenomics. 2015, in press.

Wong K.Y., LI Z., ZHANG X., Leung G.K.K., Chan G.C.F. and Chim J.C.S., Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma, Molecular Cancer. 2015, Epub on 2015-09-26.

Zhang Q., WANG L., Wong K.Y., Li Z.Y. and Chim J.C.S., Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma, J Clin Pathol. 2015, 68(7): 557-561.

Researcher : Chiu JWY

Project Title:	A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):	Chiu WYJ, Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Researcher : Chiu WYJ

Project Title:	A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):	Chiu WYJ, Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Chiu W.Y.J., Hotte S.J., Kollmannsberger C.K., Renouf D.J., Cescon D.W., Hedley D., Chow S., Moscow J., Perry M., Diaz-Padilla I., Tan D., Hirte H., McWhirter E., Chen H., Siu L.L. and Bedard P.L., A phase 1b trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in patients with advanced solid tumor, Invest New Drugs . 2016, 34(1): 204-211.

Chiu W.Y.J., Leung R.C.Y., Cheuk I., Lo J., Wong H.Y.H., Kwok G., Suen T.K.D., Chen T.H.C., Ma K.K., Chow L., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong, European Society for Medical Oncology Asia (ESMO ASIA) 2015 Congress (18-22 December, 2015). 2015.

Chiu W.Y.J., Going beyond androgen deprivation therapy: changing treatments paradigm for advanced prostate cancer , 10th Annual Scientific Meeting of Macau Urological Association 2015. 2015.

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk I., Lo J., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Intensifying taxane-carboplatin-containing neoadjuvant chemotherapy (NAC) increased response in locally advanced HER2-positive breast cancer patients with hormone receptor expression, Global Breast Cancer Conference (GBCC) 2015 (28-30 April 2016). 2016.

Chiu W.Y.J., Phase 1 Oncology Drug Trials in Hong Kong - Opportunities and Challenges, Hospital Authority Commissioned Seminar - Phase 1 Clinical Trials in Hong Kong. 2015.

Chiu W.Y.J., Recent Advancement in Cancer Immunotherapy - Transforming Cancer Treatment Paradigm with Immunotherapy, Scientific Meeting of The Society of Hospital Pharmacists of Hong Kong. 2016.

Chiu W.Y.J., The latest development of CDK4/6 inhibitor in breast cancer, Chinese Society of Clinical Oncology (CSCO) Annual Meeting. 2015.

Chiu W.Y.J., Transforming Cancer Treatment Paradigm with Immunotherapy, The University of Hong Kong Staff Clinic Invited Lecture. 2016.

Chiu W.Y.J., Update on Oncology Medicines for Breast Cancer, The Pharmaceutical Society AGM Educational Talk. 2015.

Chiu W.Y.J., update from ASCO 2016 - Systemic treatment of breast cancer, Hong Kong Breast Cancer Foundation Dinner Symposium 2016. 2016.

Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.

Yau T.C.C., Chiu W.Y.J. and Cheung T.T., What determines treatment success and future perspectives?, Postgraduate Medical Journal. 2016, 92(1085): 123-124.

Researcher : Chow WS

List of Research Outputs

Lee C.H.P., Cheung C.Y., Chow W.S., Woo Y.C., Yeung C.Y., Lang H.H.B., Fong C.H., Kwok K.H., Chen S.P. and Mak C.M., Genetics of apparently sporadic pheochromocytomaand paraganglioma in a Chinese population, Hormone and Metabolic Research. 2015, Epub on 2015-08-12.

Researcher : Chu JYS

List of Research Outputs

Chu J.Y.S., Phua Y.L., Marrone A.K., Bodnar A.J., Sims-Lucas S. and Ho J., Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival, Physiological reports. 2015, 3: 12537.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Chu LW, Lam KSL, Lee WHP
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2003

List of Research Outputs

Chiu P.W., Hui S.K., Chan Q., Azman R.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices, The 24th Annual Meeting of ISMRM, Singapore. 2016, 3219.

Chiu P.W., Hui S.K., Chan Q., Aman R.R.A.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Alterations In Glutamatergic Neurotransmission In The Anterior And Posterior Cingulate Cortices Of The Normal Aging Brain, International Alzheimer’s Disease Conference 2016. Hong Kong.

Chiu P.W., Hui S.K., Chan Q., Aman R.R.A.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Selected Proffered Paper: Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices, In: Prof. Peter B. Barker, The 24th Annual Meeting of ISMRM: Psychiatric MR Spectroscopy & Imaging Study Group. 2016.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

ZHANG Z., Shea Y.F., Chu L.W. and Song Y., Circulating MicroRNAs in Plasma as Novel Biomarkers for Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016.

Researcher : Chung ACK

Project Title:	Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):	Chung ACK, Lan HY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2008

Researcher : FEI Y

List of Research Outputs

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 21.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 24th Annual Scientific Congress of the Hong Kong College of Cardiology. J Hong Kong Coll Cardiol 2016. 24: 26.

Researcher : FENG Y

List of Research Outputs

FENG Y. and Cheung R.T.F., Neuroprotection of melatonin and/or calpeptin in a rat experimental cerebral ischaemia and reperfusion model, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 22.

Researcher : FU SN

List of Research Outputs

FU S.N., Wong C.K.H., Chin W.Y. and Luk W., Association of More Negative Attitude towards Commencing Insulin with Lower Glycosylated Hemoglobin (HbA1c) Level: A survey on Insulin-naïve Type 2 Diabetes Mellitus Chinese Patients, Journal of Diabetes & Metabolic Disorders. 2016, 15: 3.

FU S.N. and Cheung B.M.Y., Psychological insulin resistance among older patients with type 2 diabetes mellitus., Presented at 5th Asia Pacific Primary Care Research Conference, Putrajaya, Malaysia 2015.

Researcher : Fan KYY

List of Research Outputs

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Researcher : Feng Z

Project Title:	30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):	Feng Z
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Researcher : Fong HY

List of Research Outputs

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Researcher : Fung JYY

List of Research Outputs

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Chan A.C.Y., Fung J.Y.Y. and Lo C.M., Liver transplantation and hepatitis B virus infection: toward an immunoglobulin-free antiviral treatment after transplantation, Current Opinion in Organ Transplantation. 2016, 21(2): 219-223.

Chan S.C., Cheung T.T., Chan A.C.Y., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu C.L., Fan S.T. and Lo C.M., New insights after the first 1000 liver transplantations at The University of Hong Kong, Asian Journal of Surgery. 2015, Epub on 2015-07-02.

Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Cheung T.T., Wong C.L.T., Chan S.C. and Lo C.M., Comparable short and long term outcomes in living and deceased donor liver transplantation for patients with MELD score >= 35, AASLD Liver Meeting 2015, the 66th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, USA, 13-17 November 2015.

Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Dai W.C., Sharr W.W., Cheung T.T., Chan S.C. and Lo C.M., Comparable short- and long-term outcomes in living donor and deceased donor liver transplantations for patients with Model for End-stage Liver Disease scores ≥35 in a hepatitis-B endemic area, Annals of Surgery. 2016, Epub on 2016-02-17.

Fung J.Y.Y., Advances In Liver Transplantation For Hepatitis B, 14th Congress of the Asian Society of Transplantation (Singapore). 2015.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W. and Yuen R.M.F., Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases:The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 963A.

Fung J.Y.Y., Best Practices In The Management Of Hepatic Encephalopathy and Hepatorenal Syndrome, Symposium on Hepatic Encephalopathy and Hepatorenal Syndrome (Singapore). 2015.

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Emerging drugs for the treatment of hepatitis B, Expert Opinion on Emerging Drugs. 2016, 21(2): 183-193.

Fung J.Y.Y., Era of direct acting antivirals in chronic hepatitis C: Who will benefit?, World Journal of Hepatology. 2015, 7: 2543.

Fung J.Y.Y., Hepatitis B: Whats Left To Conquer, International Liver Transplant Society 21st Annual International Congress (Chicago). 2015.

Fung J.Y.Y., High Prevalence of Non-Alcoholic Fatty Liver Disease In The Chinese - Results From The Hong Kong Liver Health Census, The State Key Laboratory For Liver Research Sympsium. 2015.

Fung J.Y.Y., Is 3rd Generation NUCS Alone Prophylaxis After LT A Safe Option, European Liver & Intestine Transplant Association (ELITA) / European Society of Transplantation (ESOT) Monothematic Conference (Milan, Italy). 2016.

Fung J.Y.Y., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Long-term outcome of hepatitis b e-antigen seroclearance in chronic hepatitis B – results from the C.H.E.S.S. cohort. Poster presentation THU-125, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Supp 2): S363.

Fung J.Y.Y., Management of Special Hepatitis C Groups, Hong Kong Association for the Study of Liver Diseases and Hong Kong Society for Infectious Diseases Scientific Symposium. 2015.

Fung J.Y.Y., New And Emerging Treatments For Chronic Hepatitis B, The Society Of Physicians Of Hong Kong - Hepatitis Symposium. 2016.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Wong C.L.T., Sharr W.W., Cheung T.T., Chan A.C.Y., Dai W.C., Sin S.L., Ng I.O.L., Lai C.L., Yuen R.M.F. and Lo C.M., Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone, Liver Transplantation. 2015, 21(12): 1504-10.

Fung J.Y.Y., Peri-transplant Management of Hepatorenal Syndrome, The Liver Transplant Symposium (Singapore). 2015.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

Wong C.L.T., Fung J.Y.Y., Chan S.C. and Lo C.M., Excellent outcomes of hepatitis B core antibody positive donors with oral antiviral agent alone in liver transplantation , The Liver Meeting 2015, San Francisco, USA, 13-17 November 2015.

Wong C.L.T., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Sharr W.W., Dai W.C., Chan S.C. and Lo C.M., Excellent outcomes of liver transplantation using severely steatotic grafts from brain-dead donors, Liver Transplantation. 2015, 22(2): 226-236.

Wong C.L.T., Fung J.Y.Y., Chan M.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C., Chan S.C. and Lo C.M., Long-term outcomes of entecavir monotherapy after liver transplantation for hepatitis B – 5 years data, The 21st International Liver Transplantation Society (ILTS) Annual International Congress, Chicago, USA, 8-11 July 2015.

Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., COLD-PCR for early detection of hepatitis B virus antiviral drug resistance mutations, Hong Kong Med J. 2015, Suppl 7: 8-10.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

Yip V.S.K., Cheung T.T., Poon R.T.P., Yau T.C.C., Fung J.Y.Y., Dai W.C., Chan A.C.Y., Chok K.S.H., Chan S.C. and Lo C.M., Does hepatitis B seroconversion affect survival outcome in patients with hepatitis B related hepatocellular carcinoma?, Translational Gastroenterology and Hepatology. 2016, 1: 51.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Researcher : GAO Y

List of Research Outputs

GAO Y., Cheung R.T.F., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok M.Y.T., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 56.

GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. International Lupus Congress, 2015, Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Lau E.Y.Y., WAN H.Y., Lau W.C.S. and Mok M.Y.T., Systemic lupus erythematosus patients with past neuropsychiatric involvement are associated with worse cognitive impairment: a longitudinal study, Lupus. 2016, 25: 637-644.

GAO Y., Lau E.Y.Y., WAN H.Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. International Lupus Congress,Clin Exp Rheumatol 2015; 33 (Supp 90), , 2015, S-40.

Researcher : Gu P

List of Research Outputs

Gu P. and Hui X., Elevating circulation chemerin level is associated with endothelial dysfunction and early atherosclerotic changes in essential hypertensive patients, J Hypertens. 2015, 33: 1624.

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

Researcher : HAN HC

List of Research Outputs

Ma C.H., Man C.H., HAN H.C. and Leung A.Y.H., A novel role of Aldh16a1 in vertebrate erythropoiesis, The 8th Annual Zebrafish Disease Models ConferenceA novel role of Aldh16a1 in vertebrate erythropoiesis. 2015.

Researcher : HO KC

List of Research Outputs

CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94.

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in Prescriptions for Osteoporosis and Reduction in Hip Fracture Incidence in Hong Kong 2005-2014., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 25.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in prescriptions for osteoporosis and reduction in hip fracture incidence in Hong Kong 2005-2014., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Researcher : Hai SHJJ

Project Title:	Effect of a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist on Hypertension-Induced Atrial Remodelling
Investigator(s):	Hai SHJJ, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Lip G.Y., Lam K.S.L., Tse H.F. and Siu D.C.W., Benefit of Anticoagulation Therapy in Hyperthyroidism-Related Atrial Fibrillation, Clin Cardiol. 2015, 38(8): 476-82.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015.

Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

Hai S.H.J.J., EGM Interpretation, Practical Arrhythmic Management – Module ll : Catheter Ablation, Hong Kong Cardiac Nursing Association Ltd cum Hong Kong College of Cardiac Nursing Ltd. 2016.

Hai S.H.J.J., Elderly heart failure with preserved ejection fraction showed different predictors for cardiovascular mortality than their younger counterparts, European Society of Cardiology Congress 2015, UK. 2015.

Hai S.H.J.J., Lim E.T., Chan C.P., Chan Y.S., Chan K.K., Chong D., Ho K.L., Tan B.Y., Teo W.S., Ching C.K. and Tse H.F., First clinical experience of the safety and feasibility of total subcutaneous implantable defibrillator in an Asian population, Europace. 2015, 17: Suppl 2:ii63-8.

Hai S.H.J.J. and Tse H.F., Phrenic nerve palsy in cryoballoon ablation: Can it be prevented? , Heart Rhythm. 2016, 13(2): 352-3.

Hai S.H.J.J., Predictors of stroke in heart failure patients without atrial fibrillation, The 37th Heart Rhythm Annual Scientific Session, USA. 2016.

Hai S.H.J.J., The value of the ‘SAME-TT2R2’ score in predicting good anticoagulation control in an Asian population” and “Long QT and Brugada syndromes – a coincidence?”, The 8th Asia-Pacific Heart Rhythm Society Annual Scientific Session, Australia. 2015.

Hai S.H.J.J., Use of intracardiac ultrasound to assist ablation; An elderly AF patient with frequent falls; Anticoagulation in a patient with prior intracranial hemorrhage, The 8th Asia-Pacific Heart Rhythm Society Annual Scientific Session, Australia. 2015.

Researcher : Har WYA

List of Research Outputs

Har W.Y.A. and Kwan S.K.J., Prevalence of psychotic symptoms in patients presenting to a geriatric memory clinic in Hong Kong, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Mak S.F., Hui R., So K., Har W.Y.A., Azman R. and Mak H.K.F., Effects of small vessel disease on post-stroke clinical outcomes, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Mak S.F., Hui R., So K., Har W.Y.A., Azman R. and Mak H.K.F., Prevalence and clinical impact of white matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy on short and long term outcomes after stroke rehabilitation, 21st Medical Research Conference. 2016, 22: 28.

Kwan S.K.J., Mak S.F., Har W.Y.A., Azman R. and Mak H.K.F., White matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy in high-risk non-demented adults: prevalence and progression over 2 years, 21st Medical Research Conference. 2016, 22: 42.

Researcher : Ho JCM

Project Title:	MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:	07/2005

Project Title:	A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):	Ho JCM, Wong KYM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	02/2007

Project Title:	A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2007

Project Title:	The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Lee Wing Tat Fund
Start Date:	08/2007

Project Title:	A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	11/2007

Project Title:	A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	06/2008

Project Title:	A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	12/2008

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Hong Kong Lung Foundation Research Grant
Start Date:	02/2009

Project Title:	A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):	Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2009

Project Title:	Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2010

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	03/2011

Project Title:	A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2011

Project Title:	Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	05/2011

Project Title:	In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):	Ho JCM, Lam SK
Department:	Medicine
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2011

Project Title:	A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	02/2012

Project Title:	In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma
Investigator(s):	Ho JCM, Lam SK
Department:	Medicine
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2015

List of Research Outputs

Bai C., Choi C.M., Chu C.M., Anantham D., Ho J.C.M., Khan A.Z., Lee J.M., Li S.Y., Saenghirunvattana S. and Yim A., Evaluation of pulmonary nodules: clinical practice consensus guidelines for Asia, Chest. 2016.

Chan H.Y., Tsoi A., Wong M.P., Ho J.C.M. and Lee E.Y.P., Utility of 18F-FDG PET/CT in the assessment of lymphoepithelioma-like carcinoma, Nuclear Medicine Communications. 2016, 37(5): 437-45.

Ho J.C.M., Lam S.K., U K.P. and Cheng P.N., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft model, American Society of Clinical Oncology. 2016.

Ho J.C.M., Local news on an incident about inappropriate lung surgery in a patient with TB [in Apple Daily], 27 Aug, 2015.

Ho J.C.M., Lam S.K., U K.P. and Cheng P.N., Pegylated arginase treatment in mesothelioma xenograft models, American Society of Clinical Oncology. 2016.

Lam S.K. and Ho J.C.M., Degradation of FGFR1/Akt/Src/c-Raf/Erk by arsenic trioxide and FGFR inhibitor in squamous cell lung cancer, 16th World Conference on Lung Cancer. 2015.

Lam S.K., XU S. and Ho J.C.M., In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 30.

Price D., David-Wang A., Cho S.H., Ho J.C.M., Jeong J.W., Liam C.K., Lin J., Muttalif A.R., Perng D.W., Tan T.L., Yunus F. and Neira G., Time for a new language for asthma control: results from REALISE Asia, Journal of Asthma and Allergy. 2015, 8: 93-103.

SONG T., CHEN X., Tang S.C.W., Ho J.C.M., Lao L., Ng T.B., Lee C.K.F., Sze C.W.S. and Zhang Y., Dendrobium officinale polysaccharides ameliorated pulmonary function while inhibiting mucin-5AC and stimulating aquaporin-5 expression., Journal of functional foods. 2016, 21: 359-371.

Song T., Yang H., Ho J.C.M., Tang S.C.W., Sze C.W.S., Lao L., Wang Y. and Zhang Y., Expression of aquaporin 5 (AQP5) in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer., In: Tianhe Song, Hong Yang, James Chung Man Ho, Sydney Chi Wai Tang, Stephen Cho Wing SZE, Lixing Lao, Ying Wang, Zhang Yanbo. , Oncology Letter [IF 0.987] . 2015, 9: 2799-2804.

XU S., Lam S.K. and Ho J.C.M., The Effect of Arginase on Small Cell Lung Cancer, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 55.

Researcher : Ho JCY

List of Research Outputs

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Researcher : Ho SL

Project Title:	Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):	Ho SL, Song Y, Wang Y
Department:	Medicine
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	04/2007

Project Title:	Pathophysiological study of Parkinson's disease associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation
Investigator(s):	Ho SL, Ho WL, Siu DCW
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

List of Research Outputs

Cai J.F., Ho W.W.S., Leung G.K.K. and Ho S.L., Neuro-endovascular service in The University of Hong Kong Shenzhen Hospital, Hong Kong Neurosurgical Society 2015 Conjoint Annual Scientific Meeting, Hong Kong, 20-21 November 2015.

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Ho S.L., Chang S.K.R., Pang S.Y.Y., Li L.S.W., Chen J. and Lee M.C., Visual motor control in patients with Parkinson's disease., Journal of Vision. United States, Association for Research in Vision and Ophthalmology, 2015, 15(12): 593.

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Ho W.L., Ho S.L. and Leung K.M.Y., Risk assessment of estrogenic endocrine disruptors on adult brain dopamine homeostasis, Symposium on Environmental Health and Food Safety, Faculty of Science & Faculty of Medicine, The University of Hong Kong. 2016.

LI T.H., Hui S.K., Chan Q., McAlonan G., Ho S.L. and Mak H.K.F., Association of Brain Iron Deposition in Parkinson’s Disease with Comorbidities of Visual Hallucinations: An ROI-based Quantitative Susceptibility Mapping Study, The 24th Annual Meeting of ISMRM, Singapore. 2016, 4946.

LI T.H., Hui S.K., Chan Q., McAlonan G., Ho S.L. and Mak H.K.F., Nigral Iron Distribution in Brain of Parkinson’s Disease: A Combined Structural Voxel-wise and ROI-based Study with Quantitative Susceptibility Mapping, The 24th Annual Meeting of ISMRM, Singapore. 2016, 4958.

LI T.H., Hui S.K., Chan Q., McAlonan G., Ho S.L. and Mak H.K.F., Quantitative Susceptibility Mapping for the Evaluation of Subcortical Iron Abnormality in Parkinson’s Disease with Dementia, The 24th Annual Meeting of ISMRM, Singapore. 2016, 165.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

XU G., Ho W.L., Tse H.M., Ho S.L. and Leung K.M.Y., Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach, Environmental Pollution. 2016, 215: 103-112.

Researcher : Ho WL

Project Title:	Pathogenic mechanism of leucine-rich repeat kinase 2 (LRRK2) R1441G mutation on synaptic mitochondrial dysfunction associated with Parkinson’s disease
Investigator(s):	Ho WL, Ho SL, Liu H
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Neurotoxic effects of environmental estrogenic endocrine disruptive compounds on brain dopamine homeostasis
Investigator(s):	Ho WL, Ho SL, Leung KMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Ho W.L., Ho S.L. and Leung K.M.Y., Risk assessment of estrogenic endocrine disruptors on adult brain dopamine homeostasis, Symposium on Environmental Health and Food Safety, Faculty of Science & Faculty of Medicine, The University of Hong Kong. 2016.

Ho W.L., Understanding mitochondrial dysfunction against energy deficiency and neurodegeneration, Monthly Research Seminar, School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong. 2015.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

XU G., Ho W.L., Tse H.M., Ho S.L. and Leung K.M.Y., Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach, Environmental Pollution. 2016, 215: 103-112.

Researcher : Hong X

List of Research Outputs

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Researcher : Hoo RLC

Project Title:	The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation
Investigator(s):	Hoo RLC, Zhang J
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Interplay between adipocyte fatty acid binding protein and endoplasmic reticulum stress in toxic lipids-induced inflammation in macrophages
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Adipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity
Investigator(s):	Hoo RLC, Xia Z, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	The pathological role of adipocyte fatty acid binding protein in alcoholic fatty liver disease.
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2014
Completion Date:	09/2015

Project Title:	Deciphering the role of lipid chaperone fatty acid binding protein 4 in the development of obesity-induced diabetic nephropathy
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of ischemic stroke associating with obesity
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction.
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

List of Research Outputs

Hoo R.L.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) potentiates toxic lipids-induced endoplasmic reticulum stress and inflammation in macrophages via inhibition of Janus Kinase 2-dependent autophagy, 脂肪细胞型脂肪酸结合蛋白（A-FABP）在毒性脂质诱导的巨噬细胞炎症反应中的作用机制研究, 广东省继续医学教育项目 “血液净化临床技术的进展与应用”学习班《两岸三地粤港澳台学者研讨会, 2015.

Hoo R.L.C., Direct submission editor , Proceedings of the National Academy of Sciences . 2016.

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Hu HC, Lam CLK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1998

Researcher : Huang D

List of Research Outputs

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

Huang D., Chan P.H.M., Lam C.C., Shea P.C., Yiu K.H., Tse H.F. and Siu D.C.W., Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction, J Heart Valve Dis. 2015, 24(4): 433-5.

Researcher : Huang FY

Project Title:	Role of estorgen-inducible MiR23a in hepatocellular carcinoma
Investigator(s):	Huang FY, Wong DKH, Fung JYY, Seto WKW, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014
Completion Date:	10/2015

Project Title:	20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine; Sequence variations of full-length hepatitis B virus genomes in Chinese patients with HBsAg-negative hepatitits B infection
Investigator(s):	Huang FY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2015
Completion Date:	10/2015

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development, Oncotarget. New York, Impact Journals, LLC, 2015, 6(33): 34941-52.

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Researcher : Hui CK

Project Title:	Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):	Hui CK, Liang RHS, Lau G, Lie AKW
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Hui KMC

List of Research Outputs

Hui K.M.C., Management of COPD: experience from UK and Hong Kong, AstraZeneca Respiratory Annual Forum, Shenzhen China. 2015.

LUI M.M.S., Mak J.C.W., Lai Y.K.A., Hui K.M.C., Lam J.C.M., Lam C.L.D. and Ip M.S.M., The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration. 2016, 91: 124-131.

Liu H.L., Shih K.C., Shum J.W.H., Hui K.M.C., Lai J.S.M. and Ip M.S.M., A retrospective study on the prevalence of normal-tension glaucoma among patients with obstructive sleep apnea syndrome, Hong Kong Ophthalmological Symposium 2015.

Shih K.C., Hui K.M.C., Shum J.W.H. and Ip M.S.M., A Retrospective Study on the Prevalence of Normal Tension Glaucoma Among Patients with Obstructive Sleep Apnea Syndrome, Asia Pacific Academy of Ophthalmology 2016.

Researcher : Hui X

Project Title:	SIRT1 in perivascular adipose tissues(PVAT) as a mediator of obesity-induced endothelial dysfunction by controlling brown-to-white transition of PVAT: Molecular mechanisms and therapeutic interventions
Investigator(s):	Hui X, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	METABOLIC SIGNALING & DISEASE: FROM CELL TO ORGANISM; Adipocyte SIRT1 protects against obesity-induced endothelial dysfunction via enhancing brown-remodeling of perivascular adipose tissue in mice
Investigator(s):	Hui X
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

List of Research Outputs

Gu P. and Hui X., Elevating circulation chemerin level is associated with endothelial dysfunction and early atherosclerotic changes in essential hypertensive patients, J Hypertens. 2015, 33: 1624.

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

Hui X. and Xu A., The FGF21–adiponectin axis in controlling energy and vascular homeostasis, J Mol Cell Biol. 2016, 8: 110.

Researcher : Hui YLE

Project Title:	Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes
Investigator(s):	Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2013

Researcher : Hung FNI

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Hung F.N.I., Appropriate use of oseltamivir in the treatment and prophylaxis for influenza , Lunch symposium, APCMV Congress, Taiwan, 16 Oct 2015. (Invited speaker). 2015.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Hung F.N.I., Updated management of skin and soft tissue infection, Central surgeon group lunch meeting, AstraZeneca Hong Kong Ltd, Hong Kong, 24 September 2015. (Invited speaker). 2015.

Lam Y.F., Tong S.M., Lo O.S.H., Seto W.K.W., Hung F.N.I., Law W.L. and Leung W.K., Different adenoma recurrence rates on surveillance colonoscopy in patients with right- or left-sided colonic cancer after curative colectomy, Digestive Disease Week, San Diego, USA, 21-24 May 2016.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Shi H.Y., Chan F.K., Leung W.K., Li M.K.K., Leung C.M., Sze S.F., Ching J.Y.L., Lo F.H., Tsang S.W.C., Shan E.H.S., Mak L.Y., Lam B.C.Y., Hui A.J., Wong S.H., Wong M.T.L., Hung F.N.I., Hui Y.T., Chan Y.K., Chan K.H., Loo C.K., Tong R.W.H., Chow W.H., Ng C.K.M., Lao W.C., Harbord M., Wu J.C.Y., Sung J.J.Y. and Ng S.C., Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry, Journal of Crohn's and Colitis. 2016, 10: 176-185.

Sridhar S., Fung K.S., Chan J.F.W., Lam J.Y., Yip E.K., Hung F.N.I., Wu A.K., Que T.L., Lau S.K.P. and Woo P.C.Y., High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study., BMC Infectious Diseases. 2016, 16: 74.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Researcher : Hung I.F.N.

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Researcher : Hung IFN

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan T.C., Cheng V.C.C., Hung I.F.N., Chan F.H.W., Ng W.C. and Yuen K.Y., The Association Between Methicillin Resistant Staphylococcus aureus Colonization and Mortality in Chinese Nursing Home Older Adults: A 2-Year Prospective Cohort, Journal of the American Medical Directors Association. 2015, 16: 796-797.

Cheng V.C.C., Chau P.H., So S.Y.C., Chen J.H.K., Poon R.W.S., Wong S.C.Y., Hung I.F.N., Lee W.M., Tai J.W.M., Ho P.L., Yam W.C. and Yuen K.Y., Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1381-1386.

Cheng V.C.C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Viral Infections, an Overview with a Focus on Prevention of Transmission, Reference Module in Biomedical Sciences. Elsevier Inc., 2015.

Hung I.F.N., Invited Session Chairman of Case Discussion, Advances in Endoscopic Imaging and Diagnosis, The University of Hong Kong-Shenzhen Hospital, 29 Aug 2015.. 2015.

Hung I.F.N., The New Era of Pneumonia Management , Luncheon Meeting, Pfizer Corporation Hong Kong Limited, 10 July 2015. 2015.

Researcher : Hwang YYG

List of Research Outputs

Chan S.Y.T., Marcella S.W., Singh G.H.H., Hwang Y.Y.G. and Kwong Y.L., Posaconazole versus fluconazole or itraconazole for prevention of invasive fungal diseases in patients with acute myeloid leukemia or myelodysplastic syndrome: a cost-effectiveness analysis in an Asian teaching hospital, Journal of Medical Economics. 2015, 1-22.

Li L.F., Taw B.T.B., Pu K.S.J., Hwang Y.Y.G., Lui W.M. and Leung G.K.K., Primary CNS NK-cell lymphoma in a Chinese woman with atypical C11-choline PET and MR spectrometry findings, World Neurosurgery. 2015, Epub on 2015-07-02.

Researcher : Ip MSM

Project Title:	The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):	Ip MSM
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1997

Project Title:	The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):	Ip MSM, Peh WCG, Cooke MS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Ip MSM, Lam KSL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):	Ip MSM, Lam KSL, Song Y, Sham PC
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Impact of intermittent hypoxia on adipose tissue function in mice
Investigator(s):	Ip MSM, Mak JCW, Xu A, Lee YKM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2015
Completion Date:	11/2015

List of Research Outputs

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). ATS, 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The Presence Of Serotonin In Cigarette Smoke - A Possible Mechanism In Cigarette Smoke-Induced Airway Inflammation, Am J Respir Crit Care Med . 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanism in cigarette smoke-induced airway inflammation, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 21.

Chan G.C., Lam B., Yap Y.H.D., Ip M.S.M., Lai K.N. and Tang S.C.W., Proteinuria is associated with sleep apnea in chronic kidney disease., Nephrol Dial Transplant. 2016, 31(5): 772-9.

Han Q., Li G., Mak J.C.W., Zhang Y., Ip M.S.M. and Zhang N., The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo, Zhonghua Jie He He Hu Xi Za Zhi. 2015, 38: 516-519.

Ip M.S.M., Mehra R. and Lam K.S.L., Associations between Obstructive Sleep Apnea and Glucose Metabolism. More Than Meets the Eye, American Journal of Respiratory and Critical Care Medicine. 2015, 192: 656-658.

Ip M.S.M., Bronchiectasis, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU & QMH, Oct 2015. 2015.

Ip M.S.M., Co-chairman , Symposium on Sleep Apnoea, Autumn Respiratory Seminar cum 4th Cross-Strait 4-Region COPD Symposium, HKTS/ACCP (HK & Macau Chapter), Hong Kong, Nov 2015. 2015.

Ip M.S.M., Co-chairman, Symposium VI: Lung Pathology - Pulmonary Complications in Organ Transplant Recipients, Hong Kong Pathology Forum 2016, Jan 2016. 2016.

Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2015.

Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2015.

Ip M.S.M., Member of Editorial Board, Sleep Medicine Research of Korean Society of Sleep Medicine. 2016.

Ip M.S.M., Moderator, Poster Session "Sleep Disorders II", Chest World Congress, Shanghai, China, Apr 2016. 2016.

Ip M.S.M., Non-infectious complications post-hematopoietic stem cell transplanation, Hong Kong Pathology Forum 2016, Jan 2016. 2016.

Ip M.S.M., Oral Appliance For Obstructive Sleep Apnea, Chest World Congress 2016, Shanghai, China, April 2016. 2016.

Ip M.S.M., Updates in Clinical Respiratory Medicine, 21st Hong Kong Medical Forum, Hong Kong, May 2016. 2016.

Ip M.S.M., Updates on treatment of sleep apnea, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, Department of Medicine, HKU & QMH, Oct 2015. 2015.

LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells attenuate cigarette smoke-induced mitochondrial dysfunction and apoptosis in airway smooth muscle cells, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 39.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Poster Presentation Award at the 20th Research Postgraduate Symposium, The University of Hong Kong, Faculty of Medicine. 2015.

LUI M.M.S., Mak J.C.W., Lai Y.K.A., Hui K.M.C., Lam J.C.M., Lam C.L.D. and Ip M.S.M., The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration. 2016, 91: 124-131.

Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.W. and Ip M.S.M., A pathway underlying the effects of CPAP adherence on intimate and sexual relationships in men with obstructive sleep apnea., Sleep and Breathing. 2015.

Lam C.L.D., Luo Y., Fu K.H., Lui M.M.S., Chan K.H., Wistuba I.I., Gao B., Tsao G.S.W., Ip M.S.M. and Minna J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310: L232-L239.

Lam C.L.D., Chan C.H., Mak J.C.W., Freeman C., Ip M.S.M. and Shum D.K.Y., S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation., Scientific Reports. 2015, 5: 12945.

Lau K.W., CUI Y., Chan C.H., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation, Free Radical Research. 2016, 50: 495-502.

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Frequency Intermittent Hypoxia Reduces Endothelium-Dependent Contraction In C57 Mice With Diet-Induced Obesity, Am J Respir Crit Care Med. 2016, 193: A7734.

Lee Y.K.M., WANG Y., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators, Am J Physiol Cell Physiol. 2016, 310: C446-C455.

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low frequency intermittent hypoxia reduces endothelium-dependent contraction in C57 mice with diet-induced obesity, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 33.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Liu H.L., Shih K.C., Shum J.W.H., Hui K.M.C., Lai J.S.M. and Ip M.S.M., A retrospective study on the prevalence of normal-tension glaucoma among patients with obstructive sleep apnea syndrome, Hong Kong Ophthalmological Symposium 2015.

Liu W.K.K., CUI Y., Liang Y., Ip M.S.M. and Mak J.C.W., Age difference in responses to cigarette smoke-induced injury in a rat model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 41.

Shih K.C., Hui K.M.C., Shum J.W.H. and Ip M.S.M., A Retrospective Study on the Prevalence of Normal Tension Glaucoma Among Patients with Obstructive Sleep Apnea Syndrome, Asia Pacific Academy of Ophthalmology 2016.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). 2016, 193: A7736.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Macrophage polarization plays a role in intermittent hypoxia (IH)-impaired subcutaneous adipogensis in an IH-exposed mouse model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 51.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Various Degrees Of Intensities Of Intermittent Hypoxia On Adipogenesis In Diet-Induced Obese Mouse Model, Am J Respir Crit Care Med. 2016, 193: A7736.

Wong W.M., Tam T.C., Wong M.K., Lui M.M., Ip M.S.M. and Lam C.L.D., Managing malignant pleural effusion with an indwelling pleural catheter: factors associated with spontaneous pleurodesis, Hong Kong Medical Journal. 2016.

Researcher : Jiang X

List of Research Outputs

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Researcher : Jim MH

List of Research Outputs

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Jim M.H., Wu E.B., Fung R.C., Ng A.K., Yiu K.H., Siu D.C.W. and Ho H.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Heart Vessels.. 2015, 30(4): 427-431.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Jin Y, Kwong YL, Tsao GSW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2002

Researcher : KWOK HM

List of Research Outputs

KWOK H.M., Lam K.S.L. and Xu A., Heterogeneity of white adipose tissue: molecular basis and clinical implications, Experimental & Molecular Medicine. 2016, 48: e215.

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Researcher : Kam KM

List of Research Outputs

Yung S.S.Y., LI N., Chau K.M., Kam K.M. and Chan D.T.M., Peritonitis induces native and EDA+ fibronectin synthesis in human peritoneal mesothelial cells through PI3K and MAPK activation, ASN Kidney Week 2015.

Researcher : Kong MCW

List of Research Outputs

chen G., Karakilkes I., Chow M.Z.Y., Chopra A., Keung W., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs., 2015, 8.

Researcher : Kumana CR

List of Research Outputs

Kumana C.R., Cheung B.M.Y., Siu D.C.W., Tse H.F. and Lauder I.J., Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights, Cardiovascular Therapeutics. 2016, 34: 100-106.

TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204.

Researcher : Kung AWC

Project Title:	Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):	Kung AWC, McGhee S
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	10/2009

List of Research Outputs

Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61.

Leung Y.H., Cheung B.M.Y., Kung A.W.C., Tan K.C.B. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 35.

SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54.

Researcher : Kung MHW

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

Researcher : Kwan PYL

List of Research Outputs

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Researcher : Kwan SKJ

Project Title:	Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG
Investigator(s):	Kwan SKJ, Lee TMC, Law ACK, Mak HKF, Cheung RTF, Chang RCC, Lum TYS, Tang SCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2015

Project Title:	British Geriatrics Society Spring Meeting 2016; Communication with older Chinese patients on advanced directives: real life experience and predictive factors of successful acceptance
Investigator(s):	Kwan SKJ
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016
Completion Date:	05/2016

Project Title:	HKU Overseas Fellowship Awards 2016-17
Investigator(s):	Kwan SKJ
Department:	Medicine
Source(s) of Funding:	HKU Overseas Fellowship Awards
Start Date:	06/2016

List of Research Outputs

Cardoso I., Poynter L., Kwan S.K.J., Sharma J., Allen S. and Vassallo M., P-273: Body mass index, nutrition and rehabilitation outcome in elderly patients with cognitive impairment, European Geriatric Medicine. 2015, 6: S104-S105.

Cardoso I., Poynter L., Kwan S.K.J., Sharma J., Allen S. and Vassallo M., P-274: Should patients with severe cognitive impairment be offered rehabilitation after acute illness?, European Geriatric Medicine. 2015, 6: S105.

Chan C.F., Chiu P.K.C., Chan F.H.W., Chu L.W. and Kwan S.K.J., Communication with older Chinese patients on advance directives: real life experience and predictive factors of successful acceptance, British Geriatrics Society 2016 Spring Meeting. 2016.

Har W.Y.A. and Kwan S.K.J., Prevalence of psychotic symptoms in patients presenting to a geriatric memory clinic in Hong Kong, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Academic research: a survival guide, PhD Student Research Forum (Polytechnic University, HK). 2015.

Kwan S.K.J., Biology of Aging: Part I, Inter-hospital Geriatrics Meeting. 2016.

Kwan S.K.J., Biomarkers In Small Vessel Disease, International Alzheimer's Disease Conference 2016. 2016.

Kwan S.K.J., Xu L., Jiang C.Q., Zhang W.S., Cheung K.K. and Lam T.H., Depressive symptoms predict memory decline over subsequent 4 years: longitudinal analysis of the Guangzhou Biobank Cohort Study, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Mak S.F., Hui R., So K., Har W.Y.A., Azman R. and Mak H.K.F., Effects of small vessel disease on post-stroke clinical outcomes, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Lau H.P. and Cheung K.S.L., Frailty status influences the attitudes towards end-of-life care amongst Chinese centenarians in Hong Kong, 21st Medical Research Conference. 2016, 22: 29.

Kwan S.K.J., HKU Overseas Fellowship Award 2016-7 (UCSF Memory & Aging Center Overseas Scholarship), HKU. 2016.

Kwan S.K.J., Microparticles In Alzheimer’s Disease, Chinese Dementia Research Association. 2016.

Kwan S.K.J., Kai G., Ng B., Hui R., So K., Azman R. and Mak H.K.F., Prevalence and clinical impact of white matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy in Alzheimer's disease, 21st Medical Research Conference. 2016, 22: 28.

Kwan S.K.J., Ng B., Kai G., Hui R., So K., Azman R. and Mak H.K.F., Prevalence and clinical impact of white matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy in transient global amnesia, 21st Medical Research Conference. 2016, 22: 43.

Kwan S.K.J., Mak S.F., Hui R., So K., Har W.Y.A., Azman R. and Mak H.K.F., Prevalence and clinical impact of white matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy on short and long term outcomes after stroke rehabilitation, 21st Medical Research Conference. 2016, 22: 28.

Kwan S.K.J., Mak V.S.F., Azman R.R. and Mak H.K.F., Prevalence and risk factors for progression of structural MRI markers of cerebral aging and vascular damage in high-risk non-demented adults, VAS-COG World 2015 (Tokyo). 2015.

Kwan S.K.J., Kai G., Ng B., Hui R., So K., Azman R. and Mak H.K.F., Small vessel disease and hippocampal volume in Alzheimer's disease vs. controls, 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery". 2016.

Kwan S.K.J., Subacute (intermediate) Care In Geriatric Medicine:delivering Care Closer To Home, Korean Geriatric Society Annual Scientific Conference 2016. 2016.

Kwan S.K.J., Traumatic brain injury in older people, Inter-Hospital Geriatric Meeting (HK). 2015.

Kwan S.K.J., Mak S.F., Har W.Y.A., Azman R. and Mak H.K.F., White matter hyperintensities, cerebral microbleeds and medial temporal lobe atrophy in high-risk non-demented adults: prevalence and progression over 2 years, 21st Medical Research Conference. 2016, 22: 42.

Lau H.P., Kwan S.K.J. and Cheung K.S.L., Conceptualizing frailty as a multidimensional construct: findings from the Hong Kong Centenarian Study, Annual Meeting of Gerontological Society of America. 2015.

Lau H.P., Martin P., Kwan S.K.J. and Cheung K.S.L., Depression moderates the frailty-subjective health relationship among centenarians, Annual Meeting of Gerontological Society of America. 2015.

Lau H.P., Kwan S.K.J. and Cheung K.S.L., Overlap of Frailty, Comorbidity, Disability, and Poor Self-Rated Health in Community-Dwelling Near-Centenarians and Centenarians, Journal of the American Geriatrics Society. 2016, 64: 900-901.

Leung D.Y.P., Lo S.K.L., Leung Y.M.A., Lou V.W., Chong A.M.L., Kwan S.K.J., Chan W.C.H. and Chi I., Prevalence and correlates of abuse screening items among community-dwelling Hong Kong Chinese older adults, Geriatrics & Gerontology International. 2015, n/a-n/a.

Luo H., Lum T.Y.S., Wong G.H.Y., Kwan S.K.J., Tang Y.M.J. and Chi I., Predicting Adverse Health Outcomes in Nursing Homes: A 9-Year Longitudinal Study and Development of the FRAIL-Minimum Data Set (MDS) Quick Screening Tool, Journal of the American Medical Directors Association. 2015, 16: 1042-1047.

Price M., Günther A. and Kwan S.K.J., Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2016.

Tang W.H., Ma H.M., Lee J.S.W., Hui E., Woo J. and Kwan S.K.J., Quality of Care for Older Patients with Non-Cancer Diagnoses under the End-of-Life Care Program, Palliative Medicine and Hospice Care - Open Journal. 2016, 2: 7-13.

Vassallo M., Poynter L., Sharma J.C. and Kwan S.K.J., Nutritional risk, body mass index and rehabilitation outcome in cognitively impaired vs. cognitively normal patients, European Geriatric Medicine. 2016, 7: 122-126.

Researcher : Kwong A

Project Title:	Screening of founder and recurrent BRCA mutations in Hong Kong and US Chinese populations
Investigator(s):	Kwong A, Shin VY, Ma ESK, Chan TL
Department:	Surgery
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	A new diagnostic tool in breast cancer: immunosequencing
Investigator(s):	Kwong A, Shin VY
Department:	Surgery
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2014

Project Title:	Epigenetic alteration in BRCA-negative breast cancer patients
Investigator(s):	Kwong A, Shin VY, Chen J
Department:	Surgery
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Risk assessment of hereditary breast and ovarian cancer syndrome in Chinese population by multiple-gene sequencing
Investigator(s):	Kwong A, Shin VY
Department:	Surgery
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Tumor-derived exosomes in patients with BRCA defects
Investigator(s):	Kwong A, Shin VY
Department:	Surgery
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Cheuk I., Lo J., Wong H.Y.H., Kwok G., Suen T.K.D., Chen T.H.C., Ma K.K., Chow L., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong, European Society for Medical Oncology Asia (ESMO ASIA) 2015 Congress (18-22 December, 2015). 2015.

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk I., Lo J., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Intensifying taxane-carboplatin-containing neoadjuvant chemotherapy (NAC) increased response in locally advanced HER2-positive breast cancer patients with hormone receptor expression, Global Breast Cancer Conference (GBCC) 2015 (28-30 April 2016). 2016.

Researcher : Kwong YL

Project Title:	Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):	Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Molecular basis of arsenic resistance in tumours
Investigator(s):	Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):	Kwong YL, Liang RHS, Lie AKW, Au WY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2004

Project Title:	Provision of ibritumomab for the treatment of lymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):	Kwong YL, Au WY, Chim JCS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	05/2010

Project Title:	Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):	Kwong YL, Leung AYH, Tse EWC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia
Investigator(s):	Kwong YL, Leung AYH, Tse EWC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Provision of free azacitidine for high-risk patient with myelodysplastic syndrome (MDS)
Investigator(s):	Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2014

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

CHAU H.W.D., NG K., Chan S.Y.T., Cheng Y.Y., Fong B., Tam S., Kwong Y.L. and Tse E.W.C., Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9, Journal of Hematology & Oncology. 2015, 8.

Chan S.Y.T., Marcella S.W., Singh G.H.H., Hwang Y.Y.G. and Kwong Y.L., Posaconazole versus fluconazole or itraconazole for prevention of invasive fungal diseases in patients with acute myeloid leukemia or myelodysplastic syndrome: a cost-effectiveness analysis in an Asian teaching hospital, Journal of Medical Economics. 2015, 1-22.

Cheung C.Y.M., Ip A.L.V.I.N., Iu P.L., Lee E.Y.P. and Kwong Y.L., Retinal and central nervous system involvement in T cell large granular lymphocyte leukaemia, Annals of Hematology. 2015, 94(7): 1245-6.

Iu L.P.L., Fan C.Y., Lau K.P., Chan S.Y.T., Kwong Y.L. and Wong Y.H.I., Long-term Follow-up of Cytomegalovirus Retinitis in Non-HIV Immunocompromised Patients: Clinical Features and Visual Prognosis, American Journal of Ophthalmology. 2016, 165: 145-153.

Lee E.Y.P., Singh G.H.H., Wang Y., Kwong Y.L. and Khong P.L., Bone marrow uptake of indolent non-Hodgkin lymphoma on PET/CT with histopathological correlation, Nuclear Medicine Communications. 2015, 36(10): 1035-41.

Marinelli M., Ilari I., Xia Y., Giudice I.D., Cafforio L., Starza I.D., Raponi S., Mariglia P., Bonina S., YU Z., YANG W., QIU L., Chan S.Y.T., Piciocchi A., Kwong Y.L., Tse E.W.C., Li J., Guarini A., XU W. and Foà R., Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia, Oncotarget. 2016.

Ondrejka S.L., Moffitt A.B., Tse E.W.C., Hsi E.D., Goodlad J.R., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Gascoyne R.D., Rajagopalan D., Love C. and Dave S., Whole Exome Sequencing of Type 1 and Type 2 Enteropathy-Associated T Cell Lymphoma Reveals Genetic Basis of Eatl Oncogenesis, 57th American Society of Hematology Annual Meeting. American Society of Hematology, 2015, 126: 575.

Singh G.H.H., Leung A.Y.H., Chan C.C., Lau J.S.M., Chan C., Yip S.F., Liu H., Kho B., Mak V., Lee H.K.K., Lin S.Y., Lau C.K. and Kwong Y.L., Clinicopathologic features and prognostic indicators in Chinese patients with myelofibrosis, Hematology. 2015, 150820070832008.

Singh G.H.H., Leung A.Y.H. and Kwong Y.L., Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy, International Journal of Molecular Sciences. 2016, 17: 440.

Singh G.H.H., Leung A.Y.H. and Kwong Y.L., Molecularly targeted therapy in acute myeloid leukemia, Future Oncology. 2016.

Singh G.H.H., Lie A.K.W., Kwong Y.L. and Leung A.Y.H., Prospective Evaluation of Azacitidine Maintenance Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome, 57th ASH Annual Meeting and Exposition 2015. Blood, 126 (23).

Singh G.H.H., Leung M.K.G., Lopes D. and Kwong Y.L., The thrombopoietin mimetics eltrombopag and romiplostim in the treatment of refractory aplastic anaemia, British Journal of Haematology. 2016.

Singh G.H.H., Ip H.W., Li J., Yim R.L.H., Panagiotou I., Leung A.Y.H. and Kwong Y.L., Whole exome sequencing identifies novel mutations in relapsed or refractory acute promyelocytic leukaemia failing treatment with oral arsenic trioxide, 21st Congress of the European Hematology Association. Haematologica, 2016.

Tse E.W.C. and Kwong Y.L., Nasal NK/T-cell lymphoma: RT, CT, or both, Blood. 2015, 126: 1400-1401.

Researcher : LAW CY

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Researcher : LEE PC

List of Research Outputs

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Researcher : LEUNG WH

List of Research Outputs

LEUNG W.H., Lau B.W.M., Chan V.S.F., Lau W.C.S. and So K.F., Abnormal increase of neuronal precursor cells and exacerbated neuroinflammation in the corpus callosum in murine model of systemic lupus erythematosus, Restorative Neurology and Neuroscience. 2016, 34: 443-453.

LEUNG W.H. and Cheung R.T.F., Potential use of melatonin as a therapy for intracerebral haemorrhage, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 34.

Researcher : LI J

List of Research Outputs

LI J., Lin S., Vanhoutte P.M.G.R., Woo W.H.C. and Xu A., Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice , Circulation. 2016, 133: 2434-2446.

Woo W.H.C., CHEN J., LI J., YIU J.H.C. and Xu A., Metabolic Function of Toll like Receptor mediated by TRIF, In: Federation of American Societies for Experimental Biology, FASEB Summer Research Conference 2015, Nutritional Immunology: Role in Health and Disease. 2015.

YIU J.H.C., LI J., Xu A. and Woo W.H.C., Involvement of Toll-Like Receptor 5 Pathway in Hepatic Lipid Export, In: AAAS/Science Translational Medicine, IPSEN, HKU, Bridging Biomedical Worlds: Frontiers in Human Microbiota Symbiotic Interactions. 2016.

YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis in Visceral Adipose Tissue by Toll-like Receptor 5 Pathway, In: Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong , 11th International Symposium on Healthy Aging. 2016.

Researcher : LI L

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

Researcher : LI N

List of Research Outputs

Yung S.S.Y., LI N., Chau K.M., Kam K.M. and Chan D.T.M., Peritonitis induces native and EDA+ fibronectin synthesis in human peritoneal mesothelial cells through PI3K and MAPK activation, ASN Kidney Week 2015.

Researcher : LI R

List of Research Outputs

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : LI X

List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells attenuate cigarette smoke-induced mitochondrial dysfunction and apoptosis in airway smooth muscle cells, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 39.

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative Stress-Induced Mitochondria Alteration In Human Airway Smooth Muscle Cells And Mesenchymal Stem Cells, Am J Respir Crit Care Med. 2016, 193: A5544.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Poster Presentation Award at the 20th Research Postgraduate Symposium, The University of Hong Kong, Faculty of Medicine. 2015.

Researcher : LI Z

List of Research Outputs

Wong K.Y., LI Z., ZHANG X., Leung G.K.K., Chan G.C.F. and Chim J.C.S., Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma, Molecular Cancer. 2015, Epub on 2015-09-26.

Researcher : LIANG X

List of Research Outputs

Lian Q., Zhang Y., Liang X., Gao F. and Tse H.F., Directed Differentiation of Human-Induced Pluripotent Stem Cells to Mesenchymal Stem Cells, Methods Mol Biol. 2016, 1416: 289-98.

Sun Y., Zhang Y., Li X., Deng M., Gao W., Yao Y., CHIU S.M., LIANG X., GAO F., Chan C.W.Y., Tse H.F., Shi J., Fu Q. and Lian Q., Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice, STEM CELLS. 2015, n/a-n/a.

Zhang Y., CHIU S.M., LIANG X., GAO F., ZHANG Z., Liao S., LIANG Y., Low D. .J. .H., Tse H.F., Lian Q. and Tergaonkar V., Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction, CELL DEATH DISCOVERY. 2015.

Researcher : LIANG Y

List of Research Outputs

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Liu W.K.K., CUI Y., Liang Y., Ip M.S.M. and Mak J.C.W., Age difference in responses to cigarette smoke-induced injury in a rat model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 41.

Zhang Y., CHIU S.M., LIANG X., GAO F., ZHANG Z., Liao S., LIANG Y., Low D. .J. .H., Tse H.F., Lian Q. and Tergaonkar V., Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction, CELL DEATH DISCOVERY. 2015.

Researcher : LIU Z

List of Research Outputs

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Researcher : LUK TW

List of Research Outputs

WU H., Lo Y., LUK T.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-21.

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. Annual Scientific meeting of the American College of Rheumatology 2015. Arthritis Rheum 2015, 2015.

Researcher : Lai CL

Project Title:	A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2003

Project Title:	Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	10/2003

Project Title:	A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Idenix Pharmaceuticals, Inc - General Award
Start Date:	01/2004

Project Title:	Outstanding Researcher Award 2003-2004
Investigator(s):	Lai CL
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	07/2004

List of Research Outputs

Asselah T., Shafran S., Bourgeois S., Lai C.L., Cramp M., Mathurin P., Willems B., Nguyen M.H., Davis M.N., Huang K.C., Svarovskaia E., Osinusi A., Mcnally J., Brainard D., McHutchison J., Shaikh O.S. and Tran T.T., Sofosbuvir/Velpatasvir fixed dose combination for 12 weeks in hcv infected patients previously treated with placebo: results of the deferred treatment study (GS-US-342-1446 study). Poster presentation SAT-279, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver.. 2016, 64(Suppl 2): S827-8.

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Chan H.L.Y., Feld J.J., Agarwal K., Hezode C., Asselah T., Ruane P.J., Gruener N., Abergel A., Mangia A., Lai C.L., Mazzotta F., Moreno C., Yoshida E., Shafran S.D., Towner W.J., Tran T.T., McNally J., Brainard D.M., Jacobson I.M. and Zeuzem S., Sofosbuvir/velpatasvir (SOF/VEL) for 12 weeks in genotype 1, 2, 4, 5, 6 HCV patients: ASTRAL-1 study. Oral presentation O-018, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International 2016. 10 (Suppl 1): S12-3.

Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Prevention and management of hepatitis B virus reactivation in cancer patients, Hepatology International. 2016, 10(3): 407-414.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in chronic hepatitis B patients who achieved undetectable serum HBV DNA while on long-term nucleoside analogue therapy. Oral presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 273A.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in patients with undetectable serum HBV DNA level while on nucleos(t)ide analogues, In: Masatoshi Kudo, The 6^th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2015), Evidence and Consensus on HCC Management, July 3-5, 2015, Osaka, Japan, Liver Cancer. Switzerland, S. Karger AG, 2015, 4 (Suppl 1): 162.

Cheung K.S.M., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HCC and serum markers in NA-treated patients with undetectable HBV DNA. Poster presentation P-0577, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S298.

Feld J.J., Jacobson I.M., Hézode C., Asselah T., Ruane P.J., Gruener N., Abergel A., Mangia A., Lai C.L., Chan H.L.Y., Mazzotta F., Moreno C., Yoshida E., Shafran S.D., Towner W.J., Tran T.T., McNally J., Osinusi A., Svarovskaia E., Zhu Y., Brainard D.M., McHutchison J.G., Agarwal K. and Zeuzem S., Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection, New England Journal of Medicine. 2015, 373(27): 2599-2607.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W. and Yuen R.M.F., Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases:The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 963A.

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Emerging drugs for the treatment of hepatitis B, Expert Opinion on Emerging Drugs. 2016, 21(2): 183-193.

Fung J.Y.Y., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Long-term outcome of hepatitis b e-antigen seroclearance in chronic hepatitis B – results from the C.H.E.S.S. cohort. Poster presentation THU-125, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Supp 2): S363.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Wong C.L.T., Sharr W.W., Cheung T.T., Chan A.C.Y., Dai W.C., Sin S.L., Ng I.O.L., Lai C.L., Yuen R.M.F. and Lo C.M., Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone, Liver Transplantation. 2015, 21(12): 1504-10.

Gane E.J., Chuang W.L., Hassanein T.I., Kowdley K.V., Lawitz E., Gao B., Mo H., Hyland R.H., Yang J.C., De-Oertel S., Brainard D.M., Knox S.J., McHutchison J.G., Lai C.L. and Chan H.L.Y., Sofosbuvir and Ledipasvir/Sofosbuvir for the Treatment of Patients with Chronic Genotype 6 Hepatitis C Virus Infection: Integrated Analysis of Phase 2 and Phase 3 Studies. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 761A.

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development, Oncotarget. New York, Impact Journals, LLC, 2015, 6(33): 34941-52.

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Lai C.L., Chuang W.L., Hassanein T., Kowdley K.V., Lawitz E., Gao B., Mo H.M., Hyland R., Yang J.C., De-Oertel S., Natha M., Brainard D., Knox S.J., McHutchison J.G., Chan H.L.Y. and Gane E.J., An Integrated analysis of Phase 2,3 SOF and LDV/SOF trials for the treatment of GT6 HCV Infection, Oral presentation at the 25^th Conference of the Asian Pacific Association for the Study of the Liver, February 20-24 (APASL 2016), Tokyo, Japan, February 20-24. India, Springer India, 2016, 10 (Suppl 1): S8.

Lai C.L., Chuang W.L., Hassanein T., Kowdley K.V., Lawitz E., Gao B., Mo H., Hyland R., Yang J.C., De-Oertel S., Natha M., Brainard D., Knox S.J., McHutchison J.G., Chan H.L.Y. and Gane E.J., An Integrated analysis of phase 2,3 SOF and LDV/SOF trials for the treatment of GT6 HCV infection. Oral presentation O-009, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S8.

Lai C.L., Case Discussion: a patient with severe abdominal distension following TCM ingestion, State Key Laboratory for Liver Research (SKLLR) Symposium 2015, Hong Kong, 17^th October. 2015.

Lai C.L., Chairman, Session II: Early Clinical Research on Asian Diseases, 2^nd International Conference on Phase 1 and Early Phase Clinical Trials (ICPOEP 2015), Hong Kong, November 20‐21. 2015.

Lai C.L., Challenges and Opportunities in the Management of Chronic Hepatitis B Infection, Plenary Lecture at the 17^th International Congress on Infectious Diseases, Hyderabad, India, March 2-5. 2016.

Lai C.L., Chronic Hepatitis C, Asia Pacific AIDS & Co-infections Conference 2016 (APACC 2016), Hong Kong Exhibition & Convention Centre, Hong Kong, May 17-19. 2016.

Lai C.L., Co-chair, Asia Pacific AIDS & Co-infections Conference 2016 (APACC 2016), Hong Kong Exhibition & Convention Centre, Hong Kong, May 17-19. 2016.

Lai C.L., Getting to know Viekira Pak, Meet the Expert Dinner Symposium, Hong Kong, 22^nd October. 2015.

Lai C.L., HBV viral load versus HBsAg seroclearance versus reduction of cccDNA as endpoint of treatment, Sanofi-Union Hospital HBV Symposium, Wuhan, China, 12^th September. 2015.

Lai C.L., Hepatitis B and Other Hepatitis, Health Exhibition organized by Medical Society, HKUSU, Ma On Shan Plaza, Shatin, Hong Kong,18^th October. 2015.

Lai C.L., Hepatitis B, Seminar for Department of Chemical Pathology of the Chinese University of Hong Kong”, Hong Kong, 20^th May. 2016.

Lai C.L., Latest developments of chronic hepatitis C treatment, Joint Scientific Meeting in Chronic Hepatitis C Management co-organized by Macao Society of Gastroenterology & Hepatology and Infection Control Association of Macao, Macau, 9^th December. 2015.

Lai C.L., Member of the International Advisory Board, The Lancet Gastroenterology & Hepatology. 2016.

Lai C.L., Hui A., Chan H.L.Y., Hemmerich S., Modelska K., Neff T.B., Imperial J.C., Porter S. and Valone F.H., Placebo-controlled trial of antibody to connective tissue growth factor (CTGF) in HBV liver fibrosis. Poster presentation P-0415, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S245-6.

Lai C.L., Real World Long-term Experience of CHB Management, 8^th Annual Scientific Symposium of the Infection Control Association of Macao (ICAM), 4^th July. 2015.

Lai C.L., Reduction of cccDNA with long-term nucleos/tide analogue treatment in chronic hepatitis, 28^th Annual Scientific Meeting of the Hong Kong Association for the Study of Liver Diseases, Hong Kong, 22^nd November. 2015.

Lai C.L., Review and update on the role of NAs in the prevention of mother to child transmission, Cross Strait China, Hong Kong and Taiwan Chronic Hepatitis B Forum, Chengdu, China, 8^th August. 2015.

Lai C.L., Wong V.W.S., Yuen R.M.F., Yang J.C., Knox S.J., Mo H., Han L.L., Brainard D.M. and Chan H.L.Y., Sofosbuvir plus ribavirin for the treatment of patients with chronic genotype 1 or 6 hepatitis C virus infection in Hong Kong, Alimentary Pharmacology & Therapeutics. 2016, 43(1): 96-101.

Lai C.L., Transforming your mind”, Medical Humanities Year 2 Conversations and Connections, Guest Lecture Series, Medical Ethics and Humanities Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, March 22. 2016.

Lai C.L., Treating Chronic Hepatitis B in 2015, Seminar on Viral Hepatitis for Nurses and Allied Health Professionals 2015, Department of Health, Hong Kong, May 12. 2016.

Lai C.L., Work Group Member on HCV guideline, Kidney Disease: Improving Global Outcomes (KDIGO), . 2016.

Lai C.L., 乙型及其他肝炎, 乙型及其他肝炎, Public Seminar jointly organized by Hong Kong Hep B Free Foundation and Kowloon Lok Sin Tong, Hong Kong, 2^nd July. 2015.

Lai C.L., 乙型及其他肝炎, Public Seminar jointly organized by the Hong Kong Hep B Free Foundation and 深水埗區議會, 深水埗大坑東社區中心, Kowloon, Hong Kong, 22^th July. 2015.

Lai C.L., 乙型及其他肝炎, Public Seminar jointly organized by the Hong Kong Hep B Free Foundation and 香港廣東社團總會 - 新界東辦事處及民建聯沙田支, Shatin, Hong Kong,19^th July. 2015.

Lai C.L., 乙型及其他肝炎, Public seminar jointly organized by the Hong Kong Hep B Free Foundation, 富息居民服務社 and 宏逸居民服務社, Hong Kong, 13^th March. 2016.

Lam W.W.T., Liao Q., Wong J.H.F., Lai C.L., Yuen R.M.F., Tsang J.W.H. and Fielding R., Measuring and validating a general cancer predisposition perception scale: an adaptation of the revised-IPQ-genetic predisposition scale, PLoS One. 2015, 10: e0142620.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., DNA polymerase inhibitors for treating hepatitis B: a safety evaluation, Expert Opinion on Drug Safety. 2016, 15(3): 383-392.

Sarin S.K., Kumar M., Lau G.K., Abbas Z., Chan H.L.Y., Chen C.J., Chen D.S., Chen H.L., Chen P.J., Chien R.N., Dokmeci A.K., Gane E.D., Hou J.L., Jafri W., Jia J., Kim J.H., Lai C.L., Lee H.C., Lim S.G., Liu C.J., Locarnini S., Al Mahtab M., Mohamed R., Omata M., Park J., Piratvisuth T., Sharma B.C., Sollano J., Wang F.S., Wei L., Yuen R.M.F., Zheng S.S. and Kao J.H., Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update, Hepatology International. 2016, 10(1): 1-98.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

Walsh R., Hammond R., Yuen L., Deerain J., Given B., Schluep T., Chan H.L.Y., Lai C.L., Hamilton J., Lau J.Y., Ferrari C., Gish R.G. and Locarnini S.A., Predicting HBsAg clearance responses during ARC-520 RNA interference (RNAi) therapy based on HBsAg epitope profile analysis. Poster presentation FRI-144, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S602.

Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., COLD-PCR for early detection of hepatitis B virus antiviral drug resistance mutations, Hong Kong Med J. 2015, Suppl 7: 8-10.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

Yuen R.M.F., Ahn S.H., Chen D.S., Chen P.J., Dusheiko G.M., Hou J.L., Maddrey W.C., Mizokami M., Seto W.K.W., Zoulim F. and Lai C.L., Chronic Hepatitis B Virus Infection, Journal of Clinical Gastroenterology. 2016, 50(4): 286-294.

Yuen R.M.F., Chan H.L.Y., Liu S.H.K., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lai J.Y.N., Ferrari C. and Gish R.G., Effective inhibition of cccDNA derived mRNA/viral antigens and tolerability with ARC-520. Oral Presentation O-103, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S44.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Zhu R.X., Seto W.K.W., Lai C.L. and Yuen R.M.F., Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region, Gut and Liver. 2016, 10(3): 332-9.

Researcher : Lai KN

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

List of Research Outputs

Lai K.N., Tang S.C.W., Schena F.P., Novak J., Tomino Y., Fogo A.B. and Glassock R.J., IgA nephropathy, Nature Reviews Disease Primers. 2016, 16001.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Clinical Features, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 568-573.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Overview, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 567.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Pathogenesis, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 589-594.

Lai K.N. and Tang S.C.W., Immunoglobulin a Nephropathy: Diagnosis, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 574-579.

Lai K.N. and Tang S.C.W., Immunoglobulin a Nephropathy: Treatment and Outcome, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, c. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford . 2015, 580-588.

Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in the understanding and management of IgA nephropathy, F1000Research. 2016.

Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Tang S.C.W. and Lai K.N., Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells, Apoptosis [IF 3.614]. 2015, 20(7): 907-920.

Serino G., Pesce F., Sallustio F., De Palma G., Cox S.N., Curci C., Zaza G., Lai K.N., Leung J.C.K., Tang S.C.W., Papagianni A., Stangou M., Goumenos D., Gerolymos M., Takahashi K., Yuzawa Y., Maruyama S., Imai E. and Schena F.P., In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy, Kidney International. 2016, 89: 683-692.

Tang S.C.W., Chan G.C.W. and Lai K.N., Recent advances in managing and understanding diabetic nephropathy, F1000Research. 2016, 5: 1044.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Lai KWH

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Researcher : Lai YKA

List of Research Outputs

LUI M.M.S., Mak J.C.W., Lai Y.K.A., Hui K.M.C., Lam J.C.M., Lam C.L.D. and Ip M.S.M., The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration. 2016, 91: 124-131.

Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.W. and Ip M.S.M., A pathway underlying the effects of CPAP adherence on intimate and sexual relationships in men with obstructive sleep apnea., Sleep and Breathing. 2015.

Researcher : Lam CL

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2011

Project Title:	Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):	Lam CLD, Wan SKT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2012

Project Title:	Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

List of Research Outputs

Researcher : Lam CLD

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2011

Project Title:	Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):	Lam CLD, Wan SKT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2012

Project Title:	Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

List of Research Outputs

Fung S.C.C., Yu Y.T.E., Guo Y., Wong C.K.H., Kung K., Ho S.Y., Lam L.Y., Ip P., Fong D.Y.T., Lam C.L.D., Wong W.C.W., Tsang S.K.M., Tiwari A.F.Y. and Lam C.L.K., Development of a Health Empowerment Programme to improve the health of working poor families: protocol for a prospective cohort study in Hong Kong, BMJ Open. 2016, 6: e010015.

LUI M.M.S., Mak J.C.W., Lai Y.K.A., Hui K.M.C., Lam J.C.M., Lam C.L.D. and Ip M.S.M., The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration. 2016, 91: 124-131.

Lam C.L.D., 香港肺癌真实世界研究经验分享, 4. Annual meeting of Guangdong GHMA (广东省健康管理学会呼吸病学专业委员会) Respiratory Summit, 26 Feb, 2016, Guangzhou, China. 2016.

Lam C.L.D., Advances in the management of obstructive lung disease, FMSHK Annual Scientific Meeting 2015.

Lam C.L.D., Biomarkers in lung cancer, 3. Japanese Respiratory Society Annual Scientific Meeting 2016, Kyoto, Japan.. 2016.

Lam C.L.D., Biomarkers in lung cancer: basic research and applications., Beijing-Hong Kong-Jinan Medical Forum, 20 – 21, May, 2016, Jinan, China. 2016.

Lam C.L.D., Biomarkers in lung cancer, Japanese Respiratory Society Annual Meeting 2016, Kyoto, Japan.. 2016.

Lam C.L.D., Deputy Editor, Respirology. 2016.

Lam C.L.D., Molecular testing for NSCLC, 2015.

Lam C.L.D., Molecular testing in advanced NSCLC, APSR Annual Congress 2015, Kuala Lumpur, Malaysia.. 2015.

Lam C.L.D., Luo Y., Fu K.H., Lui M.M.S., Chan K.H., Wistuba I.I., Gao B., Tsao G.S.W., Ip M.S.M. and Minna J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310: L232-L239.

Lam C.L.D., Real world experience in management of lung cancer in Hong Kong, GHMA meeting 2016, Guangzhou, China. 2016.

Lam C.L.D., Chan C.H., Mak J.C.W., Freeman C., Ip M.S.M. and Shum D.K.Y., S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation., Scientific Reports. 2015, 5: 12945.

Lam C.L.D., Update on Asian Lung Cancer Screening: randomized and non-randomized studies, APSR Annual Congress 2015, Kuala Lumpur, Malaysia.. 2015.

Lam C.L.D., Updates on lung cancer screening in Asia: randomized and non-randomized studies, 20th Congress of the Asian Pacific Society of Respirology (APSR), 3 – 6 Dec, 2015, Kuala Lumpur, Malaysia. 2015.

Lam C.L.D., Updates on management of COPD, Annual Scientific Meeting of Federation of Medical Societies of Hong Kong 2015. 2015.

Lee C.Y., Lam C.L.D., Pang S.Y.Y., Lau G.K.K., Teo K.C., Chang S.K.R. and Chan K.H., Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese, Journal of Neuroimmunology. 2015, 289: 177-181.

Prabhakar C.N., Fong K.M., Peake M.D., Lam C.L.D. and Barnes D.J., The effectiveness of lung cancer MDT and the role of respiratory physicians, Respirology. 2015, 20 (6): 884 - 888.

Wong W.M., Tam T.C., Wong M.K., Lui M.M., Ip M.S.M. and Lam C.L.D., Managing malignant pleural effusion with an indwelling pleural catheter: factors associated with spontaneous pleurodesis, Hong Kong Medical Journal. 2016.

Researcher : Lam CLK

Project Title:	Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):	Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):	Lam CLK, Wong W
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	Extended evaluation of quality of care of chronic disease management programmes and public-private partnership programmes of the Hospital Authority
Investigator(s):	Lam CLK, Wong WCW, Chin WY, Chen JY, Fung SCC, Fong DYT, Yu YTE
Department:	Family Med & Primary Care
Source(s) of Funding:	Commissioned Study on Enhanced Primary Care
Start Date:	07/2011

Project Title:	ISPOR 18th Annual European Congress; Health-related quality of life of people from low-income families in Hong Kong, China
Investigator(s):	Lam CLK
Department:	Family Med & Primary Care
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015
Completion Date:	11/2015

Researcher : Lam CMJ

List of Research Outputs

Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.W. and Ip M.S.M., A pathway underlying the effects of CPAP adherence on intimate and sexual relationships in men with obstructive sleep apnea., Sleep and Breathing. 2015.

Researcher : Lam CSC

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

Researcher : Lam KSL

Project Title:	The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2006

Project Title:	Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
Investigator(s):	Lam KSL, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011
Completion Date:	12/2015

Project Title:	To Establish a Metabolic Study Centre in Hong Kong: Focusing on the Emerging Metabolic Hormones
Investigator(s):	Lam KSL, Xu A, Wang Y, Cheung BMY, Wong CM
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Ageing
Investigator(s):	Lam KSL, Xu A, Lum TYS
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Establishing a Phase 1 Clinical Trials Centre in Queen Mary Hospital: Extending Hong Kong's Competitive Edges in Healthcare, Education and Life Sciences Research and Development
Investigator(s):	Lam KSL, Lau YL, Cheung BMY, Lam CW, Yau HKC
Department:	Medicine
Source(s) of Funding:	Commissioned Programme on Phase 1 Clinical Trials Centre
Start Date:	02/2014

Project Title:	98th Annual Meeting of the Endocrine Society; Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Lip G.Y., Lam K.S.L., Tse H.F. and Siu D.C.W., Benefit of Anticoagulation Therapy in Hyperthyroidism-Related Atrial Fibrillation, Clin Cardiol. 2015, 38(8): 476-82.

Cheung B.M.Y., Woo Y.C., Fong C.H.Y., Xu A. and Lam K.S.L., Blood level of fibroblast growth factor 21 and blood pressure. , Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed only in the presence of peripheral vascular disease., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Diabetes is associated with increased risks of low lean mass and slow gait speed when peripheral artery disease is present, Journal of Diabetes and its Complications. 2015, 30: 306-11.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of Cutpoints for Low Lean Mass and Slow Gait Speed in Predicting Death in the National Health and Nutrition Examination Survey 1999-2004, J Gerontol A Biol Sci Med Sci.. 2016, 71: 90-5.

Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Evaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 17.

Hoo R.L.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) potentiates toxic lipids-induced endoplasmic reticulum stress and inflammation in macrophages via inhibition of Janus Kinase 2-dependent autophagy, 脂肪细胞型脂肪酸结合蛋白（A-FABP）在毒性脂质诱导的巨噬细胞炎症反应中的作用机制研究, 广东省继续医学教育项目 “血液净化临床技术的进展与应用”学习班《两岸三地粤港澳台学者研讨会, 2015.

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

Ip M.S.M., Mehra R. and Lam K.S.L., Associations between Obstructive Sleep Apnea and Glucose Metabolism. More Than Meets the Eye, American Journal of Respiratory and Critical Care Medicine. 2015, 192: 656-658.

KWOK H.M., Lam K.S.L. and Xu A., Heterogeneity of white adipose tissue: molecular basis and clinical implications, Experimental & Molecular Medicine. 2016, 48: e215.

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Ko K.Y.J., Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Ho P.C. and Ng E.H.Y., Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome, Gynecological Endocrinology. 2016, 32: 390-394.

Lam K.S.L., Editor in Chief, The Lancet Diabetes & Endocrinology Hong Kong Edition. 2016.

Lam K.S.L., Editorial Board Member, Journal of Diabetes Investigation. 2015.

Lam K.S.L., Insights on the Roles of Adipokines in Clinical Diabetes. (Plenary), 7th Asian Association for the Study of Diabetes Scientific Meeting and Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 21-22 Nov 2015, Hong Kong. 2015.

Lam K.S.L., Markers for diabetic nephropathy, International Conference on Diabetes and Metabolism, 15-17 Oct 2015, Jeju Island, Korea. 2015.

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Lam K.S.L., Chow C.C., Tan K.C.B., Ma R.C., Kong A.P., Tong P.C., Tsang M.W., Chan D.T.M., Tang S.C.W., Lee K.K., So W.Y. and Tomlinson B., Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes, Current Medical Research and Opinion. 2016, 32: 1097-1108.

Lam K.S.L., Reviewer, Clinical Endocrinology. 2015.

Lang H.H.B., Yu H.W., Lo C.Y., Lee K.E., Garcia-Barcelo M.M., Woo Y.C., Lee C.H.P., Wong K.P., Tam P.K.H. and Lam K.S.L., Bilateral pheochromocytomas in MEN2A syndrome: a two-institution experience, World Journal of Surgery. 2015, 39(10): 2484-2491.

Lee C.H.P. and Lam K.S.L., Managing non-alcoholic fatty liver disease in diabetes: challenges and opportunities, Journal of Diabetes Investigation. 2016.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Best Poster Presentation Award (Clinical), HKU O&G 90th Anniversary Celebration. 2015.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Oral glucose tolerance test should be recommended as the screening method for dysglycaemia in all Southern Chinese women with polycystic ovary syndrome., The XXI FIGO World Congress of Gynecology and Obstetrics. 2015.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome, Human Reproduction. 2015, 30: 2178-2183.

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Researcher : Lam KYJ

List of Research Outputs

Lee A.C., Lam K.Y.J., Shiu S.W.M., Wong Y., Betteridge D.J. and Tan K.C.B., Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes., PLoS One. 2015, 10(9): e0137330.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

Researcher : Lam MF

List of Research Outputs

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Researcher : Lam SK

Project Title:	Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):	Lam SK
Department:	Medicine
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Project Title:	Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):	Lam SK, Wong BCY, Lin MC
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2004

Researcher : Lam SK

Project Title:	2015 World Conference on Lung Cancer; Degradation of FGFR1/Akt/Src/c-Raf/Erk by arsenic trioxide and FGFR inhibitor in squamous cell lung cancer
Investigator(s):	Lam SK
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

Project Title:	In Vitro and in vivo combination of arginase and chemotherapeutic drugs in squamous cell lung carcinoma
Investigator(s):	Lam SK, Ho JCM
Department:	Medicine
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	03/2016

List of Research Outputs

Ho J.C.M., Lam S.K., U K.P. and Cheng P.N., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft model, American Society of Clinical Oncology. 2016.

Ho J.C.M., Lam S.K., U K.P. and Cheng P.N., Pegylated arginase treatment in mesothelioma xenograft models, American Society of Clinical Oncology. 2016.

Lam S.K. and Ho J.C.M., Degradation of FGFR1/Akt/Src/c-Raf/Erk by arsenic trioxide and FGFR inhibitor in squamous cell lung cancer, 16th World Conference on Lung Cancer. 2015.

Lam S.K., XU S. and Ho J.C.M., In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 30.

XU S., Lam S.K. and Ho J.C.M., The Effect of Arginase on Small Cell Lung Cancer, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 55.

Researcher : Lam YF

List of Research Outputs

Lam Y.F., Tong S.M., Lo O.S.H., Seto W.K.W., Hung F.N.I., Law W.L. and Leung W.K., Different adenoma recurrence rates on surveillance colonoscopy in patients with right- or left-sided colonic cancer after curative colectomy, Digestive Disease Week, San Diego, USA, 21-24 May 2016.

Lam Y.F. and Leung W.K., The Importance of Increased Serrated Polyp Detection Rate, Current Colorectal Cancer Reports. 2016, 12: 81-87.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Researcher : Lan HY

Project Title:	Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Sun Chieh Yeh Heart Foundation - General Award
Start Date:	08/2006

Project Title:	Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Baxter Health Care Ltd. - General Award
Start Date:	05/2008

Project Title:	Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	05/2008

Researcher : Lan XR

Project Title:	Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):	Lan XR, Lan HY, Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Researcher : Lau CP

Project Title:	Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):	Lau CP, Lee KLF
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/2000

Project Title:	Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):	Lau CP, Yu CM, Lan HY
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Chan P.H.M., Lau C.P., Tse H.F., Chiang C.E. and Siu D.C.W., CHA2DS2-VASc Recalibration With an Additional Age Category (50-64 Years) Enhances Stroke Risk Stratification in Chinese Patients With Atrial Fibrillation, Canadian Journal of Cardiology. 2016.

Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

Lau C.P., Siu D.C.W., Yiu K.H., Lee K.L.F., Chan Y.H. and Tse H.F., Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices, Europace. 2015, 17: ii40-ii46.

Lau C.P. and Lee K.L.F., Transcatheter Leadless Cardiac Pacing with Limited Venous Access, Pacing and Clinical Electrophysiology. 2016.

Lau Y.M. and Lau C.P., Asystole during Pulse Generator Change: Unexpected Failure of Pacemaker Implant Autoinitialization, Pacing and Clinical Electrophysiology. 2016, 39: 194-197.

Wang M.P., Chen J., Lam T.H., Lau C.P. and Chan S.S.C., Impact of secondhand smoke exposure on smoking cessation in cardiac patients, Journal of the American College of Cardiology. 2015, 66(5): 592-593.

Researcher : Lau G

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

Researcher : Lau GKK

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

Researcher : Lau GKK

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Chan K.H., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Ng C.L., Novel manifestations of anti-myelin–associated glycoprotein (MAG) antibodies neuropathy, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 11.

Lee C.Y., Lam C.L.D., Pang S.Y.Y., Lau G.K.K., Teo K.C., Chang S.K.R. and Chan K.H., Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese, Journal of Neuroimmunology. 2015, 289: 177-181.

Leung S.T.S., Lee J.C.Y., Lau G.K.K., Chang S.K.R., Pang S.Y.Y. and Ng C.L., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 37.

Leung S.T.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Chan K.H., Efficacy of beta-interferon in relapsing multiple sclerosis among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 36.

XU X., Mak H.K.F., Azman R.R., Lau G.K.K. and Hui S.K., The effect of brain microbleeds on the structural brain network after stroke, The 24th Annual Meeting of ISMRM, Singapore. 2016, 2016.

Researcher : Lau KW

List of Research Outputs

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). ATS, 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The Presence Of Serotonin In Cigarette Smoke - A Possible Mechanism In Cigarette Smoke-Induced Airway Inflammation, Am J Respir Crit Care Med . 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanism in cigarette smoke-induced airway inflammation, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 21.

Lau K.W., CUI Y., Chan C.H., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation, Free Radical Research. 2016, 50: 495-502.

Researcher : Lau VYM

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Researcher : Lau WCS

Project Title:	Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1993

Project Title:	Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):	Lau WCS, Mok MYT
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):	Lau WCS, Chan YTE, Cheung BMY
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Project Title:	Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2012

Project Title:	The role of plasmacytoid dendritic cells in systemic lupus erythematosus
Investigator(s):	Lau WCS, Chan VSF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	The role of regulatory microRNAs in plasmacytoid dendritic cell functions in systemic lupus erythematosus immunopathogenesis
Investigator(s):	Lau WCS, Chan VSF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	10/2015

Project Title:	Advances in Immunology in Health and Disease
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Croucher Summer Courses
Start Date:	07/2014

Project Title:	Validation of a new definition of lupus low disease activity state (LLDAS): Clinical and management implications
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2016

List of Research Outputs

Chen Y.J., Wu L.Y., Mok M.Y.T., Wu J.Y.J., Lintner K.E., Wang C.M., Chung E.K., yang Y., Zhou B., Wang H., Yu D.J., Alhomosh A., Jones K., Spencer C.H., Nagaraja H.N., Lau Y.L., Lau W.C.S. and Yu Y.C., Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations , Arthritis & Rheumatology. 2016, 68: 1442-1453.

GAO Y., Lau E.Y.Y., WAN H.Y., Lau W.C.S. and Mok M.Y.T., Systemic lupus erythematosus patients with past neuropsychiatric involvement are associated with worse cognitive impairment: a longitudinal study, Lupus. 2016, 25: 637-644.

LEUNG W.H., Lau B.W.M., Chan V.S.F., Lau W.C.S. and So K.F., Abnormal increase of neuronal precursor cells and exacerbated neuroinflammation in the corpus callosum in murine model of systemic lupus erythematosus, Restorative Neurology and Neuroscience. 2016, 34: 443-453.

Lau W.C.S., APLAR Treatment Recommendations for Rheumatoid Arthritis., 17th Asia Pacific League of Associations for Rheumatology Congress, Chennai, India, 5-10 September 2015. 2015.

Lau W.C.S., Chia F., Harrison A., Hsieh T.Y., Hsieh R., Hsieh S.M., Kishimoto M., Kumar A., Leong K.P., Li S., Lichauco J.J., Louthrenoo W., Luo S.F., Nash P., Ng C.T., Park S.H., Suryana B.P., Suwannalai P., Wijaya L.K., Yamamoto K., Yang Y. and Yeap S.S., APLAR rheumatoid arthritis treatment recommendations, International Journal of Rheumatic Diseases. 2015, 18: 685-713.

Lau W.C.S., To prepare a competent doctor., " International Forum on Quality & Safety in Healthcare, Asia, Hong Kong Convention and Exhibition Centre, 28-30 September 2015. 2015.

Lau W.C.S., Training future doctors surgical safety., Hong Kong Surgical Forum , Li Ka Shing Faculty of Medicine, 10 October 201. 2015.

Lim K.K., Chan M., Navarra S., Haq S.A. and Lau W.C.S., Development and implementation of Models of Care for musculoskeletal conditions in middle-income and low-income Asian countries, Best Practice & Research Clinical Rheumatology. 2016, 30: 398-419.

Lui S.F., Berwick D., Chan L.K., Chau J., Chau P., Ganotice F.J.A., Lau W.C.S., Lee V., Leung A., Leung G.K.K., Perlo J., So H.Y., Strang C., Sun D.A.V.I.D., Tam I., Wong E. and Wong M., A novel way to engage healthcare students to explore patient safety – An inter-professional, interactive, experiential learning experience workshop, International Forum on Quality and Safety in Healthcare 2016 . 2016.

Ng M.Y., Liu J., Mak H.K.F., Lau W.C.S., Tse H.F. and Yiu K.H., CT Calcium Score of Coronary Artery Calcification Progression in Rheumatoid Arthritis over a 10-year period and Risk Factors for Progression, European Congress of Radiology 2016.

XU X., Mak H.K.F., Mok T.M.Y., Lau W.C.S. and Hui S.K., Impaired small-world structural brain network in patients with neuropsychiatric systemic lupus erythematosus, The 24th Annual Meeting of ISMRM, Singapore. 2016, 318.

ZHANG J., ZHANG L., ZHANG Y., Yang J., GUO M., Sun L., Pan H.F., Hirankarn N., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W.G., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong W.S.R., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Cui Y., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations , Arthritis & Rheumatology. 2015, 67(11): 2966-77.

Researcher : Lauder IJ

List of Research Outputs

Kumana C.R., Cheung B.M.Y., Siu D.C.W., Tse H.F. and Lauder I.J., Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights, Cardiovascular Therapeutics. 2016, 34: 100-106.

Researcher : Lee CH

List of Research Outputs

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

Researcher : Lee CHP

Project Title:	The Role of Novel Serum Biomarkers and Dietary Pattern in Non-Alcoholic Fatty Liver Disease among Chinese patients with Type 2 Diabetes in Hong Kong
Investigator(s):	Lee CHP, Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Lang H.H.B., Yu H.W., Lo C.Y., Lee K.E., Garcia-Barcelo M.M., Woo Y.C., Lee C.H.P., Wong K.P., Tam P.K.H. and Lam K.S.L., Bilateral pheochromocytomas in MEN2A syndrome: a two-institution experience, World Journal of Surgery. 2015, 39(10): 2484-2491.

Lee C.H.P., 2015 – A year of SGLT2 inhibitors in Hong Kong, The Federation of Medical Societies of Hong Kong. 2016.

Lee C.H.P., Best Abstract in Clinical Medicine (Poster)-21st Medical Research Conference, Department of Medicine, The University of Hong Kong, Department of Medicine, The University of Hong Kong. 2016.

Lee C.H.P., Each Step You Take Counts in the Managing Type 2 Diabetes. , The Macau AMCGM Dinner Meeting, Macau.. 2016.

Lee C.H.P., Cheung C.Y., Chow W.S., Woo Y.C., Yeung C.Y., Lang H.H.B., Fong C.H., Kwok K.H., Chen S.P. and Mak C.M., Genetics of apparently sporadic pheochromocytomaand paraganglioma in a Chinese population, Hormone and Metabolic Research. 2015, Epub on 2015-08-12.

Lee C.H.P. and Lam K.S.L., Managing non-alcoholic fatty liver disease in diabetes: challenges and opportunities, Journal of Diabetes Investigation. 2016.

Lee C.H.P., Metabolic syndrome in primary care settings. , HKWC Structured education program, Hong Kong. 2015.

Lee C.H.P., New trends in diabetes management. , 2015 Clinical Pharmacy Conference,Shenzhen, China. 2015.

Lee C.H.P., Novel Therapeutics in Type 2 Diabetes: Role of SGLT2 inhibitors. , The 21st Hong Kong Medical Forum, Hong Kong. 2016.

Lee C.H.P., Recent Advances in Diabetes Management. , The 3rd Kiang Wu Hospital Diabetes Seminar, Macau.. 2016.

Lee C.H.P., Recent advances in diabetes management., Continuing Medical Education Talk, Hong Kong. 2016.

Lee C.H.P., The Role of Adipokines in Cancer. , 2015 International Congress on Obesity & Metabolic Syndrome, Seoul, Korea. 2015.

Lee C.H.P., Update on the Clinical Management of Phaeochromocytoma & Paraganglioma. , The 9th Huaxia Congress of Endocrinology, Taipei, Taiwan. 2015.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Researcher : Lee KK

List of Research Outputs

Lam K.S.L., Chow C.C., Tan K.C.B., Ma R.C., Kong A.P., Tong P.C., Tsang M.W., Chan D.T.M., Tang S.C.W., Lee K.K., So W.Y. and Tomlinson B., Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes, Current Medical Research and Opinion. 2016, 32: 1097-1108.

Researcher : Lee KLF

List of Research Outputs

Lau C.P., Siu D.C.W., Yiu K.H., Lee K.L.F., Chan Y.H. and Tse H.F., Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices, Europace. 2015, 17: ii40-ii46.

Lau C.P. and Lee K.L.F., Transcatheter Leadless Cardiac Pacing with Limited Venous Access, Pacing and Clinical Electrophysiology. 2016.

Researcher : Lee KWG

List of Research Outputs

ZHANG J., ZHANG L., ZHANG Y., Yang J., GUO M., Sun L., Pan H.F., Hirankarn N., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W.G., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong W.S.R., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Cui Y., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations , Arthritis & Rheumatology. 2015, 67(11): 2966-77.

Researcher : Lee MKY

List of Research Outputs

LAM C.S., Lee M.K.Y., Mak J.C.W., Fung A.C.H., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates depressive-like behaviors in high fat diet-fed mice. The 19^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 97, CP5.

LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016.

Researcher : Lee YK

Project Title:	The role of LMNA/C in regulation of cardiac nodal cell survival and electrophysiological function
Investigator(s):	Lee YK, Tse HF, Siu DCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	10th International Meeting on Substrate-Integrated Microelectrode Arrays (MEA 2016); Investigation in the Role of Lamin A (LMNA) Deficiency in Heart Block and Dilated Cardiomyopathy (DCM) Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
Investigator(s):	Lee YK
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	07/2016

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Researcher : Lee YKM

Project Title:	Interaction of intermittent hypoxia and obesity on endothelium-dependent contraction
Investigator(s):	Lee YKM, Ip MSM
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	02/2016

List of Research Outputs

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Frequency Intermittent Hypoxia Reduces Endothelium-Dependent Contraction In C57 Mice With Diet-Induced Obesity, Am J Respir Crit Care Med. 2016, 193: A7734.

Lee Y.K.M., WANG Y., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators, Am J Physiol Cell Physiol. 2016, 310: C446-C455.

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low frequency intermittent hypoxia reduces endothelium-dependent contraction in C57 mice with diet-induced obesity, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 33.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). 2016, 193: A7736.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Macrophage polarization plays a role in intermittent hypoxia (IH)-impaired subcutaneous adipogensis in an IH-exposed mouse model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 51.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Various Degrees Of Intensities Of Intermittent Hypoxia On Adipogenesis In Diet-Induced Obese Mouse Model, Am J Respir Crit Care Med. 2016, 193: A7736.

Researcher : Leung AYH

Project Title:	Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):	Leung AYH, Kwong YL, Tang SCW
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2010

Project Title:	Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Study of Microglia and Myeloid Leukemia in Zebrafish
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2013

Project Title:	A novel role of ADP-ribosylation factors-like 4a (arl4a) in definitive hematopoiesis
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2013

Project Title:	Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2014

Project Title:	Provision of free next generation sequencing (NGS) service of prognostic and therapeutic values for patients with acute myeloid leukemia in Hong Kong
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2016

List of Research Outputs

Green A.S., Maciel T.T., Hospital M.A., Yin C., Mazed F., Townsend E.C., Pilorge S., Lambert M., Paubelle E., Jacquel A., Zylbersztejn F., Decroocq J., Poulain L., Sujobert P., Jacque N., Adam K., So J.C.C., Kosmider O., Auberger P., Hermine O., Weinstock D.M., Lacombe C., Mayeux P., Vanasse G.J., Leung A.Y.H., Moura I.C., Bouscary D. and Tamburini J., Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia, Science Advances. 2015, 1: e1500221-e1500221.

Ma K.M.M., Leung A.Y.H., Lo K.Y., Lio W.I., Chan H.W., Wong I., Hau A.K., Tam C.H., Wong A.K., Kuok U.I., Chau K.F., Fung S.K., Kwan T.H., Wong S.S. and Tang S.C.W., Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis, American Journal of Nephrology. 2016, 42: 410-417.

Singh G.H.H., Leung A.Y.H. and Kwong Y.L., Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy, International Journal of Molecular Sciences. 2016, 17: 440.

Singh G.H.H. and Leung A.Y.H., Polycythemia Vera: Current Management and Emerging Treatment, In: Leon V. Berhardt, Advances in Medicine and Biology. Nova Science Publishers, 2016, 95.

Singh G.H.H., Lie A.K.W., Kwong Y.L. and Leung A.Y.H., Prospective Evaluation of Azacitidine Maintenance Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome, 57th ASH Annual Meeting and Exposition 2015. Blood, 126 (23).

Singh G.H.H., Ip H.W., Li J., Yim R.L.H., Panagiotou I., Leung A.Y.H. and Kwong Y.L., Whole exome sequencing identifies novel mutations in relapsed or refractory acute promyelocytic leukaemia failing treatment with oral arsenic trioxide, 21st Congress of the European Hematology Association. Haematologica, 2016.

Zhou Z., SUN X., MA J., Man C.H., Wong A.S.T., Leung A.Y.H. and Ngan A.H.W., Mechanical oscillations enhance gene delivery into suspended cells, Scientific Reports. 2016, 6:22824: 1-9.

Researcher : Leung CTG

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

Researcher : Leung JCK

Project Title:	Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications
Investigator(s):	Leung JCK
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	The role of kidney injury molecule in the reparative process of injured kidney tubular epithelial cells
Investigator(s):	Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

List of Research Outputs

Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in the understanding and management of IgA nephropathy, F1000Research. 2016.

Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Tang S.C.W. and Lai K.N., Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells, Apoptosis [IF 3.614]. 2015, 20(7): 907-920.

Serino G., Pesce F., Sallustio F., De Palma G., Cox S.N., Curci C., Zaza G., Lai K.N., Leung J.C.K., Tang S.C.W., Papagianni A., Stangou M., Goumenos D., Gerolymos M., Takahashi K., Yuzawa Y., Maruyama S., Imai E. and Schena F.P., In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy, Kidney International. 2016, 89: 683-692.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Leung OY

List of Research Outputs

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

Researcher : Leung RCY

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Cheuk I., Lo J., Wong H.Y.H., Kwok G., Suen T.K.D., Chen T.H.C., Ma K.K., Chow L., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong, European Society for Medical Oncology Asia (ESMO ASIA) 2015 Congress (18-22 December, 2015). 2015.

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk I., Lo J., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Intensifying taxane-carboplatin-containing neoadjuvant chemotherapy (NAC) increased response in locally advanced HER2-positive breast cancer patients with hormone receptor expression, Global Breast Cancer Conference (GBCC) 2015 (28-30 April 2016). 2016.

Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.

Researcher : Leung STS

List of Research Outputs

Leung S.T.S., Lee J.C.Y., Lau G.K.K., Chang S.K.R., Pang S.Y.Y. and Ng C.L., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 37.

Leung S.T.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Chan K.H., Efficacy of beta-interferon in relapsing multiple sclerosis among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 36.

Researcher : Leung WK

Project Title:	A prospective randomized trial to compare the safety and immunogenicity of intradermal and intramuscular influenza vaccines in patients with inflammatory bowel disease in Hong Kong
Investigator(s):	Leung WK, Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	04/2016

Project Title:	Molecular characterization of gastric microbiome in individuals at different stages of H. pylori associated gastric carcinogenesis cascade
Investigator(s):	Leung WK, Sham PC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	10/2015

Project Title:	Detection of methylated Septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer
Investigator(s):	Leung WK, Shin VY, Law WL
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Use of Fecal Calprotection for Diagnosis and Monitoring of Patients with Inflammatory Bowel Disease
Investigator(s):	Leung WK, Hung FNI, Liu SHK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2016

List of Research Outputs

Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015.

He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300.

Ho Y.C., Lo O.S.H., Leung W.K., Law W.L. and Lam W.W.M., Snapshot of complex fistula of Crohn's disease by computed tomographic enterography (Poster Presentation), ESGAR 2016, Prague, Czech Republic, 14 - 17 June 2016.

Lam Y.F., Tong S.M., Lo O.S.H., Seto W.K.W., Hung F.N.I., Law W.L. and Leung W.K., Different adenoma recurrence rates on surveillance colonoscopy in patients with right- or left-sided colonic cancer after curative colectomy, Digestive Disease Week, San Diego, USA, 21-24 May 2016.

Lam Y.F. and Leung W.K., The Importance of Increased Serrated Polyp Detection Rate, Current Colorectal Cancer Reports. 2016, 12: 81-87.

Leung W.K., Advancement of capsule endoscopy, Asia Pacific Digestive Week 2015 in Taipei. 2015.

Leung W.K., Application of capsule endoscopy in GI tract, 1st Annual Meeting of the Digestive Endoscopy Society of Taiwan 2015, Taipei. 2015.

Leung W.K., Colonic Adenoma Surveillance, GUT 2015, Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Johor Bahru, Malaysia. 2015.

Leung W.K., Development of novel strategies or new regimes, Asia Pacific Digestive Week 2015 in Taipei. 2015.

Leung W.K., Editorial Board Member, Journal of Digestive Diseases. 2016.

Leung W.K., Functional Gi Disorders: Ibd&cc, Abbott Scientific Advisory Board Meeting: Theraputic Needs/ Desires And Hurdles/ Gaps For The Management Of Gi-disease: Inventory And Consensus Regarding Asia Needs. 2016.

Leung W.K., Journal Reviewer, American Journal of Gastroenterology. 2015.

Leung W.K., Journal Reviewer, Gastroenterology. 2015.

Leung W.K., Journal Reviewer, Gut. 2015.

Leung W.K., Journal Reviewer, Journal of Gastroenterology & Hepatology. 2015.

Leung W.K., Journal Reviewer, Lancet. 2015.

Leung W.K., Member, Grant Review Board, Health and Medical Research Fund, Hong Kong SAR Government. 2016.

Leung W.K., Optimization of Inflammatory Bowel Disease Cohort Studies in Asia, Intest Res. 2015, 13(3): 208-12.

Leung W.K., Optimizing quality of care for the IBD patient in evolving economies, GUT 2015, Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Johor Bahru, Malaysia. 2015.

Leung W.K., Portfolio Gaps-patient And Physician Need: Guidelines In Asia, Abbott Scientific Advisory Board Meeting: Theraputic Needs/ Desires And Hurdles/ Gaps For The Management Of Gi-disease: Inventory And Consensus Regarding Asia Needs. 2016.

Liu S.H.K., Wong O.L. and Leung W.K., Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance , World Journal of Gastroenterology. 2016, 22(3): 1311-20.

Ng L., Wan T.M.H., Chow K.M., Man H.W., IYER D.N., Leung W.K., Yau T.C.C., Lo O.S.H., Foo C.C., Poon T.C.J., Law W.L. and Pang R.W.C., Serum microRNAs as potential biomarker for screening colorectal cancer patients (Poster Presentation), ESMO (European Society for Medical Oncology) Asia 2015 Congress, Singapore, 18-21 December 2015.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Shi H.Y., Chan F.K., Leung W.K., Li M.K.K., Leung C.M., Sze S.F., Ching J.Y.L., Lo F.H., Tsang S.W.C., Shan E.H.S., Mak L.Y., Lam B.C.Y., Hui A.J., Wong S.H., Wong M.T.L., Hung F.N.I., Hui Y.T., Chan Y.K., Chan K.H., Loo C.K., Tong R.W.H., Chow W.H., Ng C.K.M., Lao W.C., Harbord M., Wu J.C.Y., Sung J.J.Y. and Ng S.C., Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry, Journal of Crohn's and Colitis. 2016, 10: 176-185.

WONG Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin , JAMA Internal Medicine. 2016, 176(6): 828-834.

Wong C.M., Tsang H., Lai H.K., Thach T.Q., Thomas G.N., Chan K.P., Lee S.Y., Ayres J.G., Lam T.H. and Leung W.K., STROBE-long-term exposure to ambient fine particulate air pollution and hospitalization due to peptic ulcers, Medicine (Baltimore). 2016, 95(18): e3543.

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Leung YH

List of Research Outputs

Han Y., Leung Y.H., Cheung B.M.Y. and Cheung C.L., Relationship of serum vitamin D status and risk of stroke., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

Leung Y.H., Cheung B.M.Y., Kung A.W.C., Tan K.C.B. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 35.

Leung Y.H., Cheung B.M.Y. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the Seoul International Congress of Endocrinology and Metabolism 2016 in conjunction with 35th Annual Meeting of Korean Endocrine Society. 2016.

Researcher : Li FYL

List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Researcher : Li G

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Researcher : Li GR

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Researcher : Li LSW

List of Research Outputs

Ho S.L., Chang S.K.R., Pang S.Y.Y., Li L.S.W., Chen J. and Lee M.C., Visual motor control in patients with Parkinson's disease., Journal of Vision. United States, Association for Research in Vision and Ophthalmology, 2015, 15(12): 593.

Lam O.L.T., McMillan A.S., Li L.S.W. and McGrath C.P.J., Oral health and post-discharge complications in stroke survivors, Journal of Oral Rehabilitation. 2016, 43(3): 238-40.

Researcher : Li R

List of Research Outputs

Researcher : Li RA

Project Title:	Cell-based Heart Regeneration
Investigator(s):	Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2011

Project Title:	Human WT1 epicardial progenitor cells
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	Physiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Engineering Calcium Homeostasis of hESC-derived cardiomyocytes
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2013

Project Title:	Ontogenic combinatorial conditioning of 3D human pluripotent stem cell ventricular models for facilitated maturation
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2014
Completion Date:	12/2015

List of Research Outputs

Wang R., Chen S., LI C., Ng K.T.P., Kong M.C.W., Cheng J., Cheng S.H., Li R.A., Lo C.M., Man K. and Sun D., Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells, BMC Cancer. 2016, 16(1): 56.

Researcher : Li W

List of Research Outputs

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015.

Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674.

Researcher : Li WHS

List of Research Outputs

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Researcher : Lian Q

Project Title:	The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2012

Project Title:	The Roles and Mechanisms of RAP1/NFkb signaling pathway in MSC-induced immunomodulation for organ transplantation
Investigator(s):	Lian Q, Poon MW, He J
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2013

Project Title:	Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease
Investigator(s):	Lian Q, Wong DSH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2013

Project Title:	International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2013

Project Title:	Functional roles of human ESC/iPSC-derived mesenchymal stem cell-deposited matrixes for improving survive and functions of retinal pigment epithelial cell (RPE)
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Direct Mitochondrial Transfer of Stem Cells Restores Ocular Mitochondrial Dysfunction: The Role of NF-κB Activation
Investigator(s):	Lian Q, Wong DSH
Department:	Ophthalmology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Project Title:	Functional Roles of Procollagen 2a1 in the Regulation of Nkx2.5+Cardiac Progenitor Cells for Myocardial Regeneration
Investigator(s):	Lian Q, Zhang Y
Department:	Ophthalmology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Human induced pluripotent stem cells derived-nucleus pulposus cells for intervertebral disc degeneration in rats
Investigator(s):	Lian Q, Zhang Y, Cheah KSE
Department:	Ophthalmology
Source(s) of Funding:	AO Spine Asia Pacific
Start Date:	06/2016

Project Title:	International Society of Stem Cell Research (ISSCR) 2016 annunal Meeting ; HUMAN-INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS RESCUE ANTHRACYCLINE-INDUCED CARDIOMYOPATHY: ROLES OF Miro1 EXPRESSION AND TUNNELING NANOTUBE
Investigator(s):	Lian Q
Department:	Ophthalmology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	06/2016

List of Research Outputs

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Sun Y., Zhang Y., Li X., Deng M., Gao W., Yao Y., CHIU S.M., LIANG X., GAO F., Chan C.W.Y., Tse H.F., Shi J., Fu Q. and Lian Q., Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice, STEM CELLS. 2015, n/a-n/a.

Researcher : Liang Y

List of Research Outputs

Researcher : Liao S

Project Title:	Efficacy and Safety of Human Embryonic Stem Cell-derived Cardiomyocytes in Post-Myocardial Infarction Heart Failure
Investigator(s):	Liao S, Zhu Z
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Project Title:	ESC CONGRESS 2015 ; Human iPSC-MSCs is superior to human ESC-CMs for improvement of left ventricular function in a porcine model of post-myocardial infarction heart failure
Investigator(s):	Liao S
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	09/2015

List of Research Outputs

Liao S. and Tse H.F., Human iPSC-MSCs is superior to ESC-CMs for improvement of LV function in a porcine model of post-MI heart failure, ESC CONGRESS 2105. 2015.

Zhang Y., CHIU S.M., LIANG X., GAO F., ZHANG Z., Liao S., LIANG Y., Low D. .J. .H., Tse H.F., Lian Q. and Tergaonkar V., Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction, CELL DEATH DISCOVERY. 2015.

Researcher : Lie AKW

List of Research Outputs

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Singh G.H.H., Lie A.K.W., Kwong Y.L. and Leung A.Y.H., Prospective Evaluation of Azacitidine Maintenance Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome, 57th ASH Annual Meeting and Exposition 2015. Blood, 126 (23).

Researcher : Lin M

List of Research Outputs

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

Researcher : Liu H

Project Title:	20th International Congress of Parkinson’s Disease and Movement Disorders; Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice
Investigator(s):	Liu H
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	06/2016

List of Research Outputs

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Liu H., Ho W.L., LI L., Leung C.T.G., Lam C.S.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Defective ubiquitinated mitochondria accumulation in aged parkinsonian LRRK2 R1441G knockin mice, The MDS 20th International Congress of Parkinson's Disease and Movement Disorders. Berlin, Germany 2016.

Researcher : Liu J

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

Ng M.Y., Liu J., Mak H.K.F., Lau W.C.S., Tse H.F. and Yiu K.H., CT Calcium Score of Coronary Artery Calcification Progression in Rheumatoid Arthritis over a 10-year period and Risk Factors for Progression, European Congress of Radiology 2016.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : Liu SHK

List of Research Outputs

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Liu S.H.K., Wong O.L. and Leung W.K., Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance , World Journal of Gastroenterology. 2016, 22(3): 1311-20.

Liu S.H.K., Seto W.K.W., Seto W.K.W. and Yuen R.M.F., Hepatitis B: treatment choice and monitoring for response and resistance, Expert Review of Gastroenterology & Hepatology. 2016, 10(6): 697-707.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

Yuen R.M.F., Chan H.L.Y., Liu S.H.K., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lai J.Y.N., Ferrari C. and Gish R.G., Effective inhibition of cccDNA derived mRNA/viral antigens and tolerability with ARC-520. Oral Presentation O-103, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S44.

Researcher : Liu WKK

Project Title:	Effects of aging on cigarette smoke-induced inflammation in airway epithelial cells
Investigator(s):	Liu WKK, Mak JCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

List of Research Outputs

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). ATS, 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The Presence Of Serotonin In Cigarette Smoke - A Possible Mechanism In Cigarette Smoke-Induced Airway Inflammation, Am J Respir Crit Care Med . 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanism in cigarette smoke-induced airway inflammation, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 21.

Liu W.K.K., CUI Y., Liang Y., Ip M.S.M. and Mak J.C.W., Age difference in responses to cigarette smoke-induced injury in a rat model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 41.

Researcher : Liu Y

Project Title:	Role of miR-34 on Apoptosis of Podocyte
Investigator(s):	Liu Y, Tang SCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	12/2015

List of Research Outputs

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Researcher : Lo WK

List of Research Outputs

Chen J.Y., Choi P.H., Wan Y.F., Chan K.C., Tsang J.P.Y., Chan K.H., Lo W.K., Lui S.L., Chu W.L. and Lam C.L.K., Validation of the disease-specific components of the Kidney Disease Quality of Life-36 (KDQOL-36) in Chinese patients undergoing maintenance dialysis., PLOS One. 2016.

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Researcher : Lo Y

List of Research Outputs

GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. International Lupus Congress, 2015, Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Lau E.Y.Y., WAN H.Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. International Lupus Congress,Clin Exp Rheumatol 2015; 33 (Supp 90), , 2015, S-40.

WU H., Lo Y., LUK T.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-21.

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. Annual Scientific meeting of the American College of Rheumatology 2015. Arthritis Rheum 2015, 2015.

Researcher : Lui SL

List of Research Outputs

Chen J.Y., Choi P.H., Wan Y.F., Chan K.C., Tsang J.P.Y., Chan K.H., Lo W.K., Lui S.L., Chu W.L. and Lam C.L.K., Validation of the disease-specific components of the Kidney Disease Quality of Life-36 (KDQOL-36) in Chinese patients undergoing maintenance dialysis., PLOS One. 2016.

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Researcher : Luo Y

List of Research Outputs

Lam C.L.D., Luo Y., Fu K.H., Lui M.M.S., Chan K.H., Wistuba I.I., Gao B., Tsao G.S.W., Ip M.S.M. and Minna J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310: L232-L239.

Researcher : MAN KF

List of Research Outputs

MAN K.F., Leung A.Y.H. and Ma C.H., The Role of Calreticulin (Calr) in Vertebrate Hematopoiesis, The 8th Annual Zebrafish Disease Models Conference. 2015.

Researcher : Ma CH

Project Title:	The role of inka1b in zebrafish hematopoiesis
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2014
Completion Date:	01/2016

Project Title:	The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms
Investigator(s):	Ma CH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	The 8th Annual Zebrafish Disease Models Conference ; A novel role of Aldh16a1 in vertebrate erythropoiesis
Investigator(s):	Ma CH
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

Project Title:	Generating transgenic zebrafish model to study the emerging role of autophagy and mitophagy in hematopoietic diseases
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

LEUNG K.C., Lo I., Luk H.M., Tang H.M.V., Gao W., Wong W.L., Chu W.Y., Lam S.T.S., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Chinese patients with rasopathies: Detection of 29 known and novel variants using next-generation sequencing (NGS), 2015 David W. Smith Workshop on Malformations and Morphogenesis, USA, August 2015. 91.

MAN K.F., Leung A.Y.H. and Ma C.H., The Role of Calreticulin (Calr) in Vertebrate Hematopoiesis, The 8th Annual Zebrafish Disease Models Conference. 2015.

Ma C.H., Man C.H., HAN H.C. and Leung A.Y.H., A novel role of Aldh16a1 in vertebrate erythropoiesis, The 8th Annual Zebrafish Disease Models ConferenceA novel role of Aldh16a1 in vertebrate erythropoiesis. 2015.

Researcher : Ma KMM

List of Research Outputs

Ma K.M.M., Leung A.Y.H., Lo K.Y., Lio W.I., Chan H.W., Wong I., Hau A.K., Tam C.H., Wong A.K., Kuok U.I., Chau K.F., Fung S.K., Kwan T.H., Wong S.S. and Tang S.C.W., Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis, American Journal of Nephrology. 2016, 42: 410-417.

Researcher : Mak JCW

Project Title:	Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):	Mak JCW, Chan MMW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2005

Project Title:	Investigating the mechanisms of cigarette smoke-induced disruption of serotonin homeostasis in the airways in vitro and in vivo - relevant to chronic obstructive pulmonary disease
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012
Completion Date:	12/2015

Project Title:	Therapeutic Potential of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells (hiPSC-MSCs) on oxidative stress-induced
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Biological roles of estrogen in the modulation of cigarette smoke-induced inflammation in human airway epithelial cells
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	The effect of cigarette smoke on the regulation of lipocalin 2 in airway cells in vitro and in vivo – relevant to chronic obstructive pulmonary disease
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). ATS, 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The Presence Of Serotonin In Cigarette Smoke - A Possible Mechanism In Cigarette Smoke-Induced Airway Inflammation, Am J Respir Crit Care Med . 2016, 193: A4099.

CUI Y., Lau K.W., Liu W.K.K., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanism in cigarette smoke-induced airway inflammation, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 21.

Grainge C., Thomas P.S., Mak J.C.W., Benton M.J., Lim T.K. and Ko F.W., Year in review 2015: Asthma and chronic obstructive pulmonary disease, Respirology. 2016, 21: 765-775.

Han Q., Li G., Mak J.C.W., Zhang Y., Ip M.S.M. and Zhang N., The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo, Zhonghua Jie He He Hu Xi Za Zhi. 2015, 38: 516-519.

LAM C.S., Lee M.K.Y., Mak J.C.W., Fung A.C.H., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates depressive-like behaviors in high fat diet-fed mice. The 19^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 97, CP5.

LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells attenuate cigarette smoke-induced mitochondrial dysfunction and apoptosis in airway smooth muscle cells, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 39.

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative Stress-Induced Mitochondria Alteration In Human Airway Smooth Muscle Cells And Mesenchymal Stem Cells, Am J Respir Crit Care Med. 2016, 193: A5544.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Poster Presentation Award at the 20th Research Postgraduate Symposium, The University of Hong Kong, Faculty of Medicine. 2015.

LUI M.M.S., Mak J.C.W., Lai Y.K.A., Hui K.M.C., Lam J.C.M., Lam C.L.D. and Ip M.S.M., The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration. 2016, 91: 124-131.

Lam C.L.D., Chan C.H., Mak J.C.W., Freeman C., Ip M.S.M. and Shum D.K.Y., S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation., Scientific Reports. 2015, 5: 12945.

Lau K.W., CUI Y., Chan C.H., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation, Free Radical Research. 2016, 50: 495-502.

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Frequency Intermittent Hypoxia Reduces Endothelium-Dependent Contraction In C57 Mice With Diet-Induced Obesity, Am J Respir Crit Care Med. 2016, 193: A7734.

Lee Y.K.M., WANG Y., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators, Am J Physiol Cell Physiol. 2016, 310: C446-C455.

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low frequency intermittent hypoxia reduces endothelium-dependent contraction in C57 mice with diet-induced obesity, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 33.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Liu W.K.K., CUI Y., Liang Y., Ip M.S.M. and Mak J.C.W., Age difference in responses to cigarette smoke-induced injury in a rat model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 41.

Mak J.C.W., Mesenchymal stem cell treatment in chronic obstructive airway disease, Session on "Controlling exacerbation of chronic respiratory disease: current and innovative approaches" at the 13th Asia Pacific Federation of Pharmacologist Meeting (APFP). 2016.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). 2016, 193: A7736.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Macrophage polarization plays a role in intermittent hypoxia (IH)-impaired subcutaneous adipogensis in an IH-exposed mouse model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 51.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Various Degrees Of Intensities Of Intermittent Hypoxia On Adipogenesis In Diet-Induced Obese Mouse Model, Am J Respir Crit Care Med. 2016, 193: A7736.

ZHANG P., Mak J.C.W., Man R.Y.K. and Leung S.W.S., Structure-activity relationships for anti-inflammatory effect of flavonoids, The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, 22-24 July 2015, National University of Singapore. 2015.

Researcher : Mak W

List of Research Outputs

YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Inhibition Impairments in Temporal Lobe Epilepsy (TLE) Patients: Electroencephalography (EEG) Evidence from a Go/Nogo Study, 21st Medical Research Conference (HKU) . 2016, 60.

Researcher : Man CH

List of Research Outputs

Ma C.H., Man C.H., HAN H.C. and Leung A.Y.H., A novel role of Aldh16a1 in vertebrate erythropoiesis, The 8th Annual Zebrafish Disease Models ConferenceA novel role of Aldh16a1 in vertebrate erythropoiesis. 2015.

Zhou Z., SUN X., MA J., Man C.H., Wong A.S.T., Leung A.Y.H. and Ngan A.H.W., Mechanical oscillations enhance gene delivery into suspended cells, Scientific Reports. 2016, 6:22824: 1-9.

Researcher : Mathieson PW

List of Research Outputs

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Mok MY

List of Research Outputs

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Researcher : Mok MYT

Project Title:	The role of IL-33 in the modulation of macrophage differentiation and immunoregulatory functions in systemic lupus erythematosus
Investigator(s):	Mok MYT, Lau WCS, Chan GCF, Chan KW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	07/2016

Project Title:	Subgingival microbiota in patients with early and established rheumatoid arthritis
Investigator(s):	Mok MYT, Leung WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	06/2016

Project Title:	Effect of RelB silenced dendritic cells on induction of immune tolerogenicity: perspectives from systemic lupus erythematosus
Investigator(s):	Mok MYT
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	05/2016

Project Title:	Working towards better oral health and dental care for underprivileged patients with chronic inflammatory arthritis
Investigator(s):	Mok MYT, Leung KCM, Chow MK
Department:	Medicine
Source(s) of Funding:	Health Care and Promotion Fund - Research Grant Projects
Start Date:	08/2015
Completion Date:	10/2016

List of Research Outputs

Chen Y.J., Wu L.Y., Mok M.Y.T., Wu J.Y.J., Lintner K.E., Wang C.M., Chung E.K., yang Y., Zhou B., Wang H., Yu D.J., Alhomosh A., Jones K., Spencer C.H., Nagaraja H.N., Lau Y.L., Lau W.C.S. and Yu Y.C., Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations , Arthritis & Rheumatology. 2016, 68: 1442-1453.

GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok M.Y.T., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement, Twenty-first Medical Research Conference, Department of Medicine, The University of Hong Kong, 16 January 2016, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2016, 22 (Suppl 1): 56.

GAO Y., Lau E.Y.Y., WAN H.Y., Lau W.C.S. and Mok M.Y.T., Systemic lupus erythematosus patients with past neuropsychiatric involvement are associated with worse cognitive impairment: a longitudinal study, Lupus. 2016, 25: 637-644.

Researcher : Mok TMY

Project Title:	The role of IL-33 in the modulation of macrophage differentiation and immunoregulatory functions in systemic lupus erythematosus
Investigator(s):	Mok MYT, Lau WCS, Chan GCF, Chan KW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	07/2016

Project Title:	Subgingival microbiota in patients with early and established rheumatoid arthritis
Investigator(s):	Mok MYT, Leung WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	06/2016

Project Title:	Effect of RelB silenced dendritic cells on induction of immune tolerogenicity: perspectives from systemic lupus erythematosus
Investigator(s):	Mok MYT
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	05/2016

Project Title:	Working towards better oral health and dental care for underprivileged patients with chronic inflammatory arthritis
Investigator(s):	Mok MYT, Leung KCM, Chow MK
Department:	Medicine
Source(s) of Funding:	Health Care and Promotion Fund - Research Grant Projects
Start Date:	08/2015
Completion Date:	10/2016

List of Research Outputs

GAO Y., Cheung R.T.F., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. International Lupus Congress, 2015, Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-40.

GAO Y., Lau E.Y.Y., WAN H.Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. International Lupus Congress,Clin Exp Rheumatol 2015; 33 (Supp 90), , 2015, S-40.

Mok T.M.Y., News and Views from the APLAR region. International Journal of Rheumatic Diseases 2015; July 2015, 2015.

WU H., Lo Y., LUK T.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-21.

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. Annual Scientific meeting of the American College of Rheumatology 2015. Arthritis Rheum 2015, 2015.

XU X., Mak H.K.F., Mok T.M.Y., Lau W.C.S. and Hui S.K., Impaired small-world structural brain network in patients with neuropsychiatric systemic lupus erythematosus, The 24th Annual Meeting of ISMRM, Singapore. 2016, 318.

ZHANG J., ZHANG L., ZHANG Y., Yang J., GUO M., Sun L., Pan H.F., Hirankarn N., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W.G., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong W.S.R., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Cui Y., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations , Arthritis & Rheumatology. 2015, 67(11): 2966-77.

Researcher : Ng CL

Project Title:	Adiponectin deficiency elicits neuroinflammation by overwhelmed microglia activation causing Alzheimer's disease and synaptic loss in aged mice
Investigator(s):	Ng CL, Chan KH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Chan K.H., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Ng C.L., Novel manifestations of anti-myelin–associated glycoprotein (MAG) antibodies neuropathy, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 11.

Leung S.T.S., Lee J.C.Y., Lau G.K.K., Chang S.K.R., Pang S.Y.Y. and Ng C.L., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 37.

Ng C.L., Outstanding Postgraduate Student, Department of Surgery, The University of Hong Kong. 2015.

Researcher : Ng FSK

List of Research Outputs

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

Researcher : Ng KM

Project Title:	Novel Therapeutic Approach for X-linked related Danon Disease Insight from Patient-specific Pluripotent Stem Cells Platform.
Investigator(s):	Ng KM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Pathological contribution of lysosomal instability in LAMP2-deficiency induced neural dysfunction
Investigator(s):	Ng KM, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Researcher : PAN Y

List of Research Outputs

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Researcher : Pang SYY

List of Research Outputs

Chan K.H., Teo K.C., Lau G.K.K., Leung W.I., Ho S.L., Cheung R.T.F., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y. and Ng C.L., Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 10.

Chan K.H., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Ng C.L., Novel manifestations of anti-myelin–associated glycoprotein (MAG) antibodies neuropathy, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. HKMJ, 2016, 22 (Suppl 1): 11.

Ho S.L., Chang S.K.R., Pang S.Y.Y., Li L.S.W., Chen J. and Lee M.C., Visual motor control in patients with Parkinson's disease., Journal of Vision. United States, Association for Research in Vision and Ophthalmology, 2015, 15(12): 593.

Ho W.L., Pang S.Y.Y., Liu H., Lam C.S.C., Leung C.T.G., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of chaperone-mediated autophagy prevents accumulation of oligomeric a-synuclein in LRRK2 R1441G knockin mice of Parkinson’s disease, The 68th AAN Annual Meeting, American Academy of Neurology, Vancouver BC Canada 2016.

Lee C.Y., Lam C.L.D., Pang S.Y.Y., Lau G.K.K., Teo K.C., Chang S.K.R. and Chan K.H., Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese, Journal of Neuroimmunology. 2015, 289: 177-181.

Leung S.T.S., Lee J.C.Y., Lau G.K.K., Chang S.K.R., Pang S.Y.Y. and Ng C.L., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 37.

Leung S.T.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Lau G.K.K., Teo K.C. and Chan K.H., Efficacy of beta-interferon in relapsing multiple sclerosis among Hong Kong Chinese, 21st Medical Research Conference, Department of Medicine, The University of Hong Kong. Hong Kong, HKMJ, 2016, 22 (Suppl 1): 36.

Researcher : SHU L

List of Research Outputs

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Researcher : Seto WKW

Project Title:	Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure
Investigator(s):	Seto WKW, Kwong YL, Lie AKW, Wong DKH, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2013

Project Title:	Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B
Investigator(s):	Seto WKW, Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2014

Project Title:	Provision of Controlled Attenuated Parameter Measurements for the Identification of Non-Alcoholic Fatty Liver Disease and Disease Monitoring of Liver Cirrhosis
Investigator(s):	Seto WKW, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Proteomic screening for potential protein biomarker(s) associated with spontaneous HBsAg seroclearance in patients with chronic hepatitis B infection
Investigator(s):	Seto WKW, Wong DKH, Huang FY, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Prevention and management of hepatitis B virus reactivation in cancer patients, Hepatology International. 2016, 10(3): 407-414.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in chronic hepatitis B patients who achieved undetectable serum HBV DNA while on long-term nucleoside analogue therapy. Oral presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 273A.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in patients with undetectable serum HBV DNA level while on nucleos(t)ide analogues, In: Masatoshi Kudo, The 6^th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2015), Evidence and Consensus on HCC Management, July 3-5, 2015, Osaka, Japan, Liver Cancer. Switzerland, S. Karger AG, 2015, 4 (Suppl 1): 162.

Cheung K.S.M., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HCC and serum markers in NA-treated patients with undetectable HBV DNA. Poster presentation P-0577, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S298.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W. and Yuen R.M.F., Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases:The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 963A.

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Emerging drugs for the treatment of hepatitis B, Expert Opinion on Emerging Drugs. 2016, 21(2): 183-193.

Fung J.Y.Y., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Long-term outcome of hepatitis b e-antigen seroclearance in chronic hepatitis B – results from the C.H.E.S.S. cohort. Poster presentation THU-125, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Supp 2): S363.

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development, Oncotarget. New York, Impact Journals, LLC, 2015, 6(33): 34941-52.

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Lam Y.F., Tong S.M., Lo O.S.H., Seto W.K.W., Hung F.N.I., Law W.L. and Leung W.K., Different adenoma recurrence rates on surveillance colonoscopy in patients with right- or left-sided colonic cancer after curative colectomy, Digestive Disease Week, San Diego, USA, 21-24 May 2016.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Liu S.H.K., Seto W.K.W., Seto W.K.W. and Yuen R.M.F., Hepatitis B: treatment choice and monitoring for response and resistance, Expert Review of Gastroenterology & Hepatology. 2016, 10(6): 697-707.

Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., DNA polymerase inhibitors for treating hepatitis B: a safety evaluation, Expert Opinion on Drug Safety. 2016, 15(3): 383-392.

Poh Z., Shen L., Yang H.I., Seto W.K.W., Wong V.W., Lin C.Y., Goh B.B., Chang P.E., Chan H.L.Y., Yuen R.M.F., Chen C.J. and Tan C.K., Real-world risk score for hepatocellular carcinoma (RWS-HCC): a clinically practical risk predictor for HCC in chronic hepatitis B, Gut. 2016, 65(5): 887-888.

Seto W.K.W., A new treatment option for chronic HCV infection, Macau Chinese Medical Association Symposium. 2015.

Seto W.K.W., Colonoscopy and quality assurance, Colonoscopy Quality Assurance Symposium, Shenzhen, China. 2016.

Seto W.K.W., Controlled attenuation parameter and liver stiffness measurements – partners in the assessment of NAFLD. 5th Conference of Macau Society of Gastroenterology, 2015.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Distinguished Research Paper Award for Young Investigator 2015, Hong Kong College of Physicians. 2015.

Seto W.K.W., H pylori eradication: optimized management, Round-table expert panel meeting, Huizhou, Guangdong province, China. 2016.

Seto W.K.W., HBV and immunosuppression: appropriate risk stratification, Hong Kong Association for the Study of Liver Disease Annual Scientific Meeting. 2015.

Seto W.K.W., HCV Direct-acting Antivirals: Real World Data, Hong Kong Association for the Study of Liver Disease Symposium. 2016.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Hepatology (Hong Kong Edition), Wiley Publishing Asia, 2015.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Management of chronic hepatitis C genotype 1b, Hepatitis C Direct-acting Antiviral Conference, Shenzhen. 2016.

Seto W.K.W., New treatment options for chronic HCV infection, Shenzhen Infectious Disease Annual Meeting. 2015.

Seto W.K.W., Optimized management of chronic hepatitis B during immunosuppressive therapy, Chengdu, China, 2015.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

Seto W.K.W., Traditional Chinese medicine induced liver toxicity, Hong Kong Hospital Authority Convention. 2016.

Seto W.K.W., Update on the treatment for HBV, State Key Laboratory for Liver Research Symposium. 2015.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

Yuen R.M.F., Ahn S.H., Chen D.S., Chen P.J., Dusheiko G.M., Hou J.L., Maddrey W.C., Mizokami M., Seto W.K.W., Zoulim F. and Lai C.L., Chronic Hepatitis B Virus Infection, Journal of Clinical Gastroenterology. 2016, 50(4): 286-294.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Zhu R.X., Seto W.K.W., Lai C.L. and Yuen R.M.F., Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region, Gut and Liver. 2016, 10(3): 332-9.

Researcher : Shea YF

List of Research Outputs

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

ZHANG Z., Shea Y.F., Chu L.W. and Song Y., Circulating MicroRNAs in Plasma as Novel Biomarkers for Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016.

Researcher : Shen J

Project Title:	Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):	Shen J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Project Title:	Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions
Investigator(s):	Shen J, Chung SK, So KF, Yang D
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012
Completion Date:	10/2015

Project Title:	Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions
Investigator(s):	Shen J, Yang D, Chen X
Department:	School of Chinese Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Exploration of dietary compound isoliquiritigenin in chemosensitizing breast cancer stem cells by targeting aberrant β–catenin signalling
Investigator(s):	Shen J, Chen J, Wang Z
Department:	School of Chinese Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural stem/progenitor cells through activating Notch signaling pathway
Investigator(s):	Shen J, So KF, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Roles of Caveolin-1 in Regulating T lymphocytes Infiltration through Blood Brain Barrier in Pathological Process of Experimental Autoimmune Encephalomyelitis
Investigator(s):	Shen J, Chan GCF, Wu W
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Exploring Caveolin-1 as a Novel Molecular Target for Hampering T lymphocytes Infiltration through Blood Brain Barrier and Attenuating Disease Progress in Experimental Autoimmune Encephalomyelitis
Investigator(s):	Shen J, Chan GCF, Wu W
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Elucidating the role of HMGB1in blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):	Shen J, Chen X, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Exploring the neuroprotective effect and toxickinetics of An-Gong-Niu-Huang Wan in ischemic rat stroke model
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	03/2015
Completion Date:	12/2016

Project Title:	Exploring HMGB1 signaling as molecular target in peroxynitrite-mediated blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):	Shen J, Yang D, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Elucidating Impacts of Reactive Nitrogen Species-mediated Excessive Mitophagy on Cerebral Ischemic-Reperfusion Injury and Exploring the Neuroprotective Mechanisms of Naringin for Inhibition of Excessive Mitophagy
Investigator(s):	Shen J, Chen X
Department:	School of Chinese Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Exploring Effects of Glycyrrhizin, an Active Compound from Glycyrrhizae Radix, on Attenuating Delayed Tissue-plasminogen Activator (t-PA) Treatment-induced Hemorrhagic Transformation in Ischemic Stroke
Investigator(s):	Shen J, Chen X, Fung ML, Chen H
Department:	School of Chinese Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Evaluating the neuroprotective effect and safety of An-Gong-Niu-Huang Wan and its ingredients in ischemic stroke
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	06/2016

Researcher : Shih AZL

List of Research Outputs

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

Researcher : Shiu SWM

List of Research Outputs

Lee A.C., Lam K.Y.J., Shiu S.W.M., Wong Y., Betteridge D.J. and Tan K.C.B., Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes., PLoS One. 2015, 10(9): e0137330.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Cholesterol efflux capacity in type 2 diabetic patients with advanced kidney disease., 23rd World Diabetes Congress, Vancouver, Dec 2015.. 2015.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Macrophage cholesterol efflux in type 2 diabetes mellitus., The Endocrine Society’s 98th Annual Meeting, Boston, Apr 2016.. 2016.

Researcher : Sin WC

List of Research Outputs

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

Researcher : Singh GHH

Project Title:	Mechanisms of leukaemic transformation from myelodysplastic syndromes (MDS) failing treatment with demethylating agents.
Investigator(s):	Singh GHH, Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Role of Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in relapsed acute promyelocytic leukaemia (APL) treated with oral arsenic trioxide
Investigator(s):	Singh GHH, Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2015
Completion Date:	02/2016

Project Title:	Mechanisms of resistance in acute promyelocytic leukaemia failing treatment with oral arsenic trioxide
Investigator(s):	Singh GHH, Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2015
Completion Date:	11/2015

Project Title:	Determination of Prognosis in Patients with Myelofibrosis Using Novel Molecular Markers
Investigator(s):	Singh GHH, Kwong YL, So JCC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan S.Y.T., Marcella S.W., Singh G.H.H., Hwang Y.Y.G. and Kwong Y.L., Posaconazole versus fluconazole or itraconazole for prevention of invasive fungal diseases in patients with acute myeloid leukemia or myelodysplastic syndrome: a cost-effectiveness analysis in an Asian teaching hospital, Journal of Medical Economics. 2015, 1-22.

Lee E.Y.P., Singh G.H.H., Wang Y., Kwong Y.L. and Khong P.L., Bone marrow uptake of indolent non-Hodgkin lymphoma on PET/CT with histopathological correlation, Nuclear Medicine Communications. 2015, 36(10): 1035-41.

Singh G.H.H., Leung A.Y.H., Chan C.C., Lau J.S.M., Chan C., Yip S.F., Liu H., Kho B., Mak V., Lee H.K.K., Lin S.Y., Lau C.K. and Kwong Y.L., Clinicopathologic features and prognostic indicators in Chinese patients with myelofibrosis, Hematology. 2015, 150820070832008.

Singh G.H.H., Management algorithm for MPN in Hong Kong, The Second Hong Kong Myeloproliferative Neoplasm (MPN) Working Group Meeting. 2016.

Singh G.H.H., Leung A.Y.H. and Kwong Y.L., Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy, International Journal of Molecular Sciences. 2016, 17: 440.

Singh G.H.H., Leung A.Y.H. and Kwong Y.L., Molecularly targeted therapy in acute myeloid leukemia, Future Oncology. 2016.

Singh G.H.H., Myelofibrosis - current data and prognostic assessment, The Second Hong Kong Myeloproliferative Neoplasm (MPN) Working Group Meeeting. 2016.

Singh G.H.H. and Leung A.Y.H., Polycythemia Vera: Current Management and Emerging Treatment, In: Leon V. Berhardt, Advances in Medicine and Biology. Nova Science Publishers, 2016, 95.

Singh G.H.H., Lie A.K.W., Kwong Y.L. and Leung A.Y.H., Prospective Evaluation of Azacitidine Maintenance Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome, 57th ASH Annual Meeting and Exposition 2015. Blood, 126 (23).

Singh G.H.H., The Role of Hematopoietic Stem Cell Transplant in the Treatment of Acute Promyelocytic Leukemia, Scientific Conference 2015, Princess Margaret Hospital, Hong Kong.. 2015.

Singh G.H.H., Leung M.K.G., Lopes D. and Kwong Y.L., The thrombopoietin mimetics eltrombopag and romiplostim in the treatment of refractory aplastic anaemia, British Journal of Haematology. 2016.

Singh G.H.H., Ip H.W., Li J., Yim R.L.H., Panagiotou I., Leung A.Y.H. and Kwong Y.L., Whole exome sequencing identifies novel mutations in relapsed or refractory acute promyelocytic leukaemia failing treatment with oral arsenic trioxide, 21st Congress of the European Hematology Association. Haematologica, 2016.

Researcher : Siu DCW

Project Title:	Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):	Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	Cardiac fibroblasts derived Human induced pluripotent cells for cardiac regeneration
Investigator(s):	Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

List of Research Outputs

Chan E.W., LAU C.Y., Siu D.C.W., Lip G.Y.H., Leung W.K., Anand S., Man K.C.K. and Wong I.C.K., The impact of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study, Heart Rhythm. 2016, 13 (8): 1581 -1588.

Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Lip G.Y., Lam K.S.L., Tse H.F. and Siu D.C.W., Benefit of Anticoagulation Therapy in Hyperthyroidism-Related Atrial Fibrillation, Clin Cardiol. 2015, 38(8): 476-82.

Chan P.H.M., Lau C.P., Tse H.F., Chiang C.E. and Siu D.C.W., CHA2DS2-VASc Recalibration With an Additional Age Category (50-64 Years) Enhances Stroke Risk Stratification in Chinese Patients With Atrial Fibrillation, Canadian Journal of Cardiology. 2016.

Chan P.H.M. and Siu D.C.W., Clinical Benefit of Warfarin in Dialysis Patients With Atrial Fibrillation, J Am Coll Cardiol. 2015, 66(11): 1310-1.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015.

Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674.

HE Y., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., Non-vitamin k antagonist oral anticoagulants and gastrointestinal bleeding: a systematic review with meta-analysis of observational studies., 9th ISPE, Bangkok, Thailand 14-16th November (oral).. 2015.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between Non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies., 2016, 82(1): 285-300.

Huang D., Chan P.H.M., Lam C.C., Shea P.C., Yiu K.H., Tse H.F. and Siu D.C.W., Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction, J Heart Valve Dis. 2015, 24(4): 433-5.

Jim M.H., Wu E.B., Fung R.C., Ng A.K., Yiu K.H., Siu D.C.W. and Ho H.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Heart Vessels.. 2015, 30(4): 427-431.

Kumana C.R., Cheung B.M.Y., Siu D.C.W., Tse H.F. and Lauder I.J., Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights, Cardiovascular Therapeutics. 2016, 34: 100-106.

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lau C.P., Siu D.C.W., Yiu K.H., Lee K.L.F., Chan Y.H. and Tse H.F., Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices, Europace. 2015, 17: ii40-ii46.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Liu C.C., Li L., Lam Y.W., Siu D.C.W. and Cheng S.H., Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation., Sci Rep. 2016, 6: 25073.

Siu D.C.W., 2015 Interviewee, RTHK: Doctor and You 2015"心律不正”, 2015.

Siu D.C.W., 2015 Interviewee,有線新聞《至FIT男女》Sudden Health, 2015.

Siu D.C.W., 2015 Interviewee,香港電台《健康大道》心律不正”, 2015.

Siu D.C.W., 2015 Interviewee,香港電台《精靈一點》心臟科檢查須知, 2015.

Siu D.C.W., 2015 Invited Speaker, Hong Kong Heart Foundation Lecture, Hong Kong College of Cardiology, Hong Kong: “Stroke prevention in atrial fibrillation amongst Chinese: A not-to-miss opportunity.”, 2015.

Siu D.C.W., 2015 Invited Speaker, Regional SPAF Academy in Beijing and Shanghai, “ SPAF strategy in Asian Patients with NOAC”, 2015.

Siu D.C.W., 2015 Invited Speaker, Sir David Todd Lecture, Hong Kong College of Physicians, Hong Kong: “Cardiac Arrhythmias: From fast to slow, from patients, gene to stem cells, from a clinician to a basic scientist.”, 2015.

Siu D.C.W., 2015 Public, HKU Press Conference: “Cardiovascular Research & Atrial Fibrillation Public Education and Screening Program.”, 2015.

Siu D.C.W., 2016 Interviewee,有線新聞《至FIT男女》靜脈栓塞, 2016.

Siu D.C.W., 2016 Invited Speaker, Macau Cardiology Association ASM 2016. Macau: “Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure.”, 2016.

Siu D.C.W., 2016 Invited Speaker, Pan Pearl River Delta Heart Failure Forum, Shenzhen, China “Focus on the HR Management, Optimize heart treatment”, 2016.

Siu D.C.W., 2016 Invited Speaker, Stroke Scientific Meeting and Taiwan Heart Rhythm Society Annual Meeting, Taipei, Taiwan: “The new World of anticoagulation: NOACs in 2016 and beyond.”, 2016.

Siu D.C.W., 2016 Invited Speaker, TCM Alliance Meeting, Chengdu, China.”SPAF Practical Consideration in Asian Patients.”, 2015.

Siu D.C.W., 2016 Invited Speaker, TCM Alliances Meeting, Kunming, China: “SPAF Practical Consideration in Asian Patients”, 2016.

Siu D.C.W., 2016 Invited Speaker, Thrombosis Forum, Taipei, Taiwan: “NOACS in clinical practice: Step into my world”, 2016.

Siu D.C.W., Distinguished Young Fellow (Medicine), Hong Kong Academy of Medicine, Hong Kong. 2015.

Siu D.C.W., HKU Press, HK successfully performs the first implantation of a newly developed defibrillator in Asia, 2015.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Wong Y.S., Root A., Douglas I., Chui S.L.C., Chan E.W., Ghebremichael-Weldeselassie Y., Siu D.C.W., Smeeth L. and Wong I.C.K., Cardiovascular outcomes associated with use of clarithromycin: population based study., BMJ. 2016, 352: h6926.

Xiao L., Siu D.C.W., Yeung K., Leung A., Yuen M.K. and Wong Y.C., MRI of the cervical spine with 3D gradient echo sequence at 3 T: initial experience., Clinical Radiology. 2015, 70(9): 926-931.

Researcher : Siu SC

List of Research Outputs

Wong C.K.H., JIAO F., Siu S.C., Fung S.C.C., Fong D.Y.T., Wong K.W., Yu Y.T.E., Lo Y.C.Y. and Lam C.L.K., Cost-Effectiveness of a Short Message Service Intervention to Prevent Type 2 Diabetes from Impaired Glucose Tolerance, Journal of Diabetes Research. Hindawi Publishing Corporation, 2016, 2016: 1219581.

Researcher : TSOI MF

List of Research Outputs

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 94.

Cheung C.L., HO K.C., SING C.W., TSOI M.F., CHENG K.F. and Cheung B.M.Y., Randomised controlled trial of the effect of phytosterol-enriched low-fat milk on lipid profile in Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 18.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Compliance of disease modifying anti-rheumatic drugs in rheumatoid arthritis patients: a longitudinal study., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF-alpha inhibitor on subclinical atherosclerosis in rheumatoid arthritis patients: a meta-analysis., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 19.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury due to cosmetic cream in Hong Kong: a retrospective case series., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 21.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: meta-analysis of randomized controlled trials., Presented at the 24th Annual Scientific Congress of the Hong Kong College of Cardiology. J Hong Kong Coll Cardiol 2016. 24: 26.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in Prescriptions for Osteoporosis and Reduction in Hip Fracture Incidence in Hong Kong 2005-2014., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 25.

HO K.C., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Increase in prescriptions for osteoporosis and reduction in hip fracture incidence in Hong Kong 2005-2014., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population 1999-2012., Presented at the 13th Asia Pacific Federation of Pharmacologist Meeting 2016, Bangkok. 2016.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 50.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Blood lead level in the US population: analysis of the US National Health Nutrition and Examination Survey 1999-2012., Presented at the Symposium on Environmental Health and Food Safety, University of Hong Kong, 2016.

TSOI M.F., Cheung C.L., Cheung T.T. and Cheung B.M.Y., Continual Decrease in Blood Lead Level in Americans: United States National Health Nutrition and Examination Survey 1999-2014, The American Journal of Medicine. 2016.

TSOI M.F., Cheung A.J., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Decrease in blood lead level in the United States Population: United States National Health Nutrition and Examination Survey (NHANES) 1999-2014., Presented at the11th International Symposium on Healthy Aging 2016, Hong Kong. 2016.

TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204.

TSOI M.F., Cheung A.J., Cheung T.T. and Cheung B.M.Y., Fall in blood lead level in the US population 1999-2012., Presented at the 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, and 10th Across the Strati Scientific Conference on Cardiovascular Science 2015, Hong Kong. J Hong Kong Coll Cardiol 2015. 23: 122.

Researcher : TSUN GS

List of Research Outputs

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Cholesterol efflux capacity in type 2 diabetic patients with advanced kidney disease., 23rd World Diabetes Congress, Vancouver, Dec 2015.. 2015.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Macrophage cholesterol efflux in type 2 diabetes mellitus., The Endocrine Society’s 98th Annual Meeting, Boston, Apr 2016.. 2016.

Researcher : Tan KCB

Project Title:	Advanced glycation end product receptors in diabetes
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Genetic Screening of Familial Hypercholesterolemia in Hong Kong
Investigator(s):	Tan KCB, Yeung CY, Siu DCW, Leung YYJ, Pang HK, Cheung CL
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

List of Research Outputs

CHENG K.F., SING C.W., HO K.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Chung C.K., Serum calcium and incident diabetes: a retrospective study in Hong Kong Chinese and meta-analysis., Presented at the ISPE 9th Asian Conference on Pharmacoepidemiology 2015, Bangkok. 2015.

Chau T.K., Fong D.Y.T., Chan S.S.C., Wong J.Y.H., Li W.H.C., Tan K.C.B., Leung A.Y.M., Wong C.N., Leung D.Y.P. and Lam T.H., Misconceptions about smoking in patients with type 2 diabetes mellitus: a qualitative analysis, Journal of Clinical Nursing. 2015, 24(17-18): 2545-2553.

Cheung C.L., SING C.W., Tang S.M., CHENG K.F., Pirmohamed M., Choi C.H., Hung C.S., Lau E.Y., Lee K.F., Mak M.W., Leung J.Y., Wong T.W., Ho A.Y., Chan K.W., Hung V.H., Tam V., Siu S.C., Sham P.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B. and Kung A.W.C., HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis , Clinical Pharmacology & Therapeutics. 2015, 99: 555-61.

Lam K.S.L., Chow C.C., Tan K.C.B., Ma R.C., Kong A.P., Tong P.C., Tsang M.W., Chan D.T.M., Tang S.C.W., Lee K.K., So W.Y. and Tomlinson B., Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes, Current Medical Research and Opinion. 2016, 32: 1097-1108.

Lee A.C., Lam K.Y.J., Shiu S.W.M., Wong Y., Betteridge D.J. and Tan K.C.B., Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes., PLoS One. 2015, 10(9): e0137330.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Leung Y.H., Cheung B.M.Y., Kung A.W.C., Tan K.C.B. and Cheung C.L., Vitamin binding protein, 25-hydroxyvitamin D and bioavailable vitamin D status in Hong Kong Chinese., Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 35.

SING C.W., CHENG K.F., Ho K.C., Kung A.W.C., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Salas-Salvadó J., Becerra-Tomas N. and Cheung C.L., Serum calcium and incident diabetes: an observational study and meta-analysis, Osteoporosis International. 2015, 27: 1747-54.

Tan K.C.B., Chairman of the Scientific Committee, 7th Scientific Meeting of the Asia Association for the Study of Diabetes, Nov 2015, Hong Kong. 2015.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Cholesterol efflux capacity in type 2 diabetic patients with advanced kidney disease., 23rd World Diabetes Congress, Vancouver, Dec 2015.. 2015.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Macrophage cholesterol efflux in type 2 diabetes mellitus., The Endocrine Society’s 98th Annual Meeting, Boston, Apr 2016.. 2016.

Tan K.C.B., “Hyperlipidaemia – how to treat ?"., 1st Chapter Meeting of the Hong Kong Edition of the Lancet Diabetes & Endocrinology- Optimizing Patient Care in Diabetes, Nov 2015, Hong Kong.. 2015.

Tan K.C.B., “Lipid management in diabetes – perspective from an endocrinologist”, A to Z Symposium on Diabetes, Apr 2016, Hong Kong.. 2016.

Tan K.C.B., “Role of the Advanced Glycation End Products Pathway in Diabetic Complications”., 9th International Huaxia Congress of Endocrinology, Dec 2015, Taipei. 2015.

Tan K.C.B., “SGLT2 inhibitors - a novel class for the treatment of type 2 diabetes”., 7th Scientific Meeting of the Asia Association for the Study of Diabetes, Nov 2015, Hong Kong.. 2015.

Tan K.C.B., “The glucose lowering effects of SGLT2 inhibitors”, Hongkong Adventist Hospital CME, Apr 2016, Hong Kong.. 2016.

Tan K.C.B., “Update on Treatment Guidelines in Diabetes – Lipid Targets”., 7th Scientific Meeting of the Asia Association for the Study of Diabetes, Nov 2015, Hong Kong.. 2015.

Tan K.C.B., “Weight management in diabetes with novel treatment"., Eleventh International Symposium on Healthy Aging, Mar 2016 , Hong Kong.. 2016.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

Researcher : Tan V.P.Y.

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):	Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

List of Research Outputs

Researcher : Tan VPY

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):	Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

List of Research Outputs

Iacovou M., Tan V.P.Y., Muir J.G. and Gibson P.R., The Low FODMAP Diet and Its Application in East and Southeast Asia, Journal of Neurogastroenterology and Motility. 2015.

Researcher : Tang CW

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):	Tang SCW, Yiu WH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012
Completion Date:	12/2015

Project Title:	King's/HKU Fellowship Awards 2012-13
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	07/2012

Project Title:	Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):	Tang SCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Wnt/beta-catenin signaling in kidney proximal tubular cells
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):	Tang SCW, Feng Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):	Tang SCW, Liu Y, Yiu WH
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

List of Research Outputs

Researcher : Tang SCW

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):	Tang SCW, Yiu WH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012
Completion Date:	12/2015

Project Title:	King's/HKU Fellowship Awards 2012-13
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	07/2012

Project Title:	Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):	Tang SCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Wnt/beta-catenin signaling in kidney proximal tubular cells
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):	Tang SCW, Feng Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):	Tang SCW, Liu Y, Yiu WH
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

List of Research Outputs

Chan G.C., Lam B., Yap Y.H.D., Ip M.S.M., Lai K.N. and Tang S.C.W., Proteinuria is associated with sleep apnea in chronic kidney disease., Nephrol Dial Transplant. 2016, 31(5): 772-9.

Chan G.C.W. and Tang S.C.W., Diabetic Nephropathy: Landmark: clinical trials and tribulations, Nephrol Dial Transplant. 2016, 31: 359-368.

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

Cheung C.Y.S., Chan G.C.W., Chan S.K., Ng F.S.K., Lam M.F., Wong S.H., Chak W.L., Chau K.F., Lui S.L., Lo W.K. and Tang S.C.W., Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study, American Journal of Nephrology. 2016, 43: 153-159.

LIU J., CHEN X., Tang S.C.W., Sze C.W.S., Feng Y., Lee C.K.F. and Zhang Y., Chinese medicines in the treatment of experimental diabetic nephropathy, Chinese Medicine. 2016, 11: 6.

Lai K.N., Tang S.C.W., Schena F.P., Novak J., Tomino Y., Fogo A.B. and Glassock R.J., IgA nephropathy, Nature Reviews Disease Primers. 2016, 16001.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Clinical Features, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 568-573.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Overview, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 567.

Lai K.N. and Tang S.C.W., Immunoglobulin A Nephropathy: Pathogenesis, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 589-594.

Lai K.N. and Tang S.C.W., Immunoglobulin a Nephropathy: Diagnosis, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, C. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford. 2015, 574-579.

Lai K.N. and Tang S.C.W., Immunoglobulin a Nephropathy: Treatment and Outcome, In: Oxford Textbook of Clinical Nephrology, 4th ed., Edited by N. Turner, D. Goldsmith, c. Winearls, N. Lameire, J. Himmelfarb, G. Remuzzi, Oxford University Press, Oxford . 2015, 580-588.

Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in the understanding and management of IgA nephropathy, F1000Research. 2016.

Lam K.S.L., Chow C.C., Tan K.C.B., Ma R.C., Kong A.P., Tong P.C., Tsang M.W., Chan D.T.M., Tang S.C.W., Lee K.K., So W.Y. and Tomlinson B., Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes, Current Medical Research and Opinion. 2016, 32: 1097-1108.

Leung J.C.K., Chan Y.Y., Saleem M.A., Mathieson P.W., Tang S.C.W. and Lai K.N., Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells, Apoptosis [IF 3.614]. 2015, 20(7): 907-920.

Ma K.M.M., Leung A.Y.H., Lo K.Y., Lio W.I., Chan H.W., Wong I., Hau A.K., Tam C.H., Wong A.K., Kuok U.I., Chau K.F., Fung S.K., Kwan T.H., Wong S.S. and Tang S.C.W., Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis, American Journal of Nephrology. 2016, 42: 410-417.

SONG T., CHEN X., Tang S.C.W., Ho J.C.M., Lao L., Ng T.B., Lee C.K.F., Sze C.W.S. and Zhang Y., Dendrobium officinale polysaccharides ameliorated pulmonary function while inhibiting mucin-5AC and stimulating aquaporin-5 expression., Journal of functional foods. 2016, 21: 359-371.

Serino G., Pesce F., Sallustio F., De Palma G., Cox S.N., Curci C., Zaza G., Lai K.N., Leung J.C.K., Tang S.C.W., Papagianni A., Stangou M., Goumenos D., Gerolymos M., Takahashi K., Yuzawa Y., Maruyama S., Imai E. and Schena F.P., In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy, Kidney International. 2016, 89: 683-692.

Song T., Yang H., Ho J.C.M., Tang S.C.W., Sze C.W.S., Lao L., Wang Y. and Zhang Y., Expression of aquaporin 5 (AQP5) in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer., In: Tianhe Song, Hong Yang, James Chung Man Ho, Sydney Chi Wai Tang, Stephen Cho Wing SZE, Lixing Lao, Ying Wang, Zhang Yanbo. , Oncology Letter [IF 0.987] . 2015, 9: 2799-2804.

Tang S.C.W., "Anti-inflammatory action of BMP7 in diabetic nephropathy: an emerging role?", Cross-Strait International Conference on Nephrology 兩岸四地腎臟病學術會議, Sun Yat-sen University, Guangzhou, China. 2015.

Tang S.C.W., "Is sleep apnea a really major problem in CKD? Hypotheses and observations" in a symposium titled "Lingering questions in CKD", Congress of the European Renal Association and European Dialysis and Transplant Association, Vienna Austria. 2016.

Tang S.C.W., "Role of the tubule in diabetic nephropathy" in a symposium titled "It's not just insulin: diabetic agents and amelioration of kidney injury", American Society of Nephrology Kidney Week, San Diego, CA, USA [top academic international conference in nephrology]*. 2015.

Tang S.C.W., "The role of kidney in glucose homeostasis in type 2 diabetes", CME lecture, Hong Kong Adventist Hospital. 2016.

Tang S.C.W., "Toll-like receptors in diabetic nephropathy", 深圳 - 香港醫學科學協同創新中心成立大會, Shenzhen, China. 2015.

Tang S.C.W., "Treatment of diabetic nephropathy - new perspectives", Nanjing International Nephrology Forum and National CME Program, Nanjing, China. 2015.

Tang S.C.W., "Update on Diabetic Nephropathy" , Update on Diabetes Management K.K. Leung Diabetes Centre, The University of Hong Kong . 2015.

Tang S.C.W., Biomedicine Hub, Editorial Board. KARGER, 2015.

Tang S.C.W., F1000Research, Editorial Advisory Board. Science Navigation Group, 2015.

Tang S.C.W., Immunosuppressive treatment for IgA nephropathy - when and how?", 1st International Congress for Chinese Nephrologists (ICCN), Hong Kong. 2015.

Tang S.C.W., Journal of the American Society of Nephrology, Guest Editor. American Society of Nephrology, 2016.

Tang S.C.W., Kidney Disease and Transplantation, Editorial Board. Biomed Central, 2015.

Tang S.C.W., Kidney Diseases, Editorial Board. KARGER, 2015.

Tang S.C.W., Pioneer in Kidney Diseases, Editorial Board. Whioce Publishing Pte. Ltd, 2015.

Tang S.C.W., Chan G.C.W. and Lai K.N., Recent advances in managing and understanding diabetic nephropathy, F1000Research. 2016, 5: 1044.

Tang S.C.W., Treatment of diabetic kidney disease: landmark studies and tribulations, CME Course at the Annual Scientific Meeting of the Japanese Society of Nephrology, Yokohama Japan. 2016.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Tang YFV

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk I., Lo J., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Intensifying taxane-carboplatin-containing neoadjuvant chemotherapy (NAC) increased response in locally advanced HER2-positive breast cancer patients with hormone receptor expression, Global Breast Cancer Conference (GBCC) 2015 (28-30 April 2016). 2016.

Researcher : Tong SM

List of Research Outputs

Lam Y.F., Tong S.M., Lo O.S.H., Seto W.K.W., Hung F.N.I., Law W.L. and Leung W.K., Different adenoma recurrence rates on surveillance colonoscopy in patients with right- or left-sided colonic cancer after curative colectomy, Digestive Disease Week, San Diego, USA, 21-24 May 2016.

Researcher : Tsang JJ

List of Research Outputs

Lam W.W.T., Yoon S.W., Sze W.K., Ng A.W., Soong I., Kwong A., Suen T.K.D., Tsang J.J., Yeo W., Wong K.Y. and Fielding R., Comparing the meanings of living with advanced breast cancer between women resilient to distress and women with persistent distress: a qualitative study, Psycho-Oncology. 2016, Epub on 2016-04-26.

Researcher : Tsang JWH

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang WHJ, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):	Tsang WHJ, Khoo US
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

Project Title:	Personalized Medicine for Elderly Breast Cancer Patients (CRF)
Investigator(s):	Tsang WHJ
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015
Completion Date:	02/2016

List of Research Outputs

Wong O.L., Tsang J.W.H., Cowling B.J. and Leung G.M., Generalised cost-effectiveness analysis for breast cancer prevention and care in Hong Kong Chinese, Hong Kong Medical Journal. 2015, 21(Suppl 6): S9-12.

Researcher : Tse EWC

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Extending the therapeutic application of arsenic trioxide in acute myeloid leukaemia
Investigator(s):	Tse EWC, Kwong YL
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

CHAU H.W.D., NG K., Chan S.Y.T., Cheng Y.Y., Fong B., Tam S., Kwong Y.L. and Tse E.W.C., Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9, Journal of Hematology & Oncology. 2015, 8.

Marinelli M., Ilari I., Xia Y., Giudice I.D., Cafforio L., Starza I.D., Raponi S., Mariglia P., Bonina S., YU Z., YANG W., QIU L., Chan S.Y.T., Piciocchi A., Kwong Y.L., Tse E.W.C., Li J., Guarini A., XU W. and Foà R., Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia, Oncotarget. 2016.

Ondrejka S.L., Moffitt A.B., Tse E.W.C., Hsi E.D., Goodlad J.R., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Gascoyne R.D., Rajagopalan D., Love C. and Dave S., Whole Exome Sequencing of Type 1 and Type 2 Enteropathy-Associated T Cell Lymphoma Reveals Genetic Basis of Eatl Oncogenesis, 57th American Society of Hematology Annual Meeting. American Society of Hematology, 2015, 126: 575.

Tse E.W.C. and Kwong Y.L., Nasal NK/T-cell lymphoma: RT, CT, or both, Blood. 2015, 126: 1400-1401.

Researcher : Tse HF

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):	Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan HWF, Lam L, Lee KLF, Chan WS, Lam YM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):	Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2012

Project Title:	Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention
Investigator(s):	Tse HF, Schooling CM, Cowling BJ, Sham PC, Lam TH, Chan YH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2012

Project Title:	Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells
Investigator(s):	Tse HF, Ho JCY
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013

Project Title:	Effects of Catheter-based Splanchnic Denervation on Blood Pressure Control and Left Ventricular Remodeling in Porcine Model of Hypertensive Cardiomyopathy
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management
Investigator(s):	Tse HF, Siu DCW, Lai KWH
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	12/2014

Project Title:	Lower Thoracic Spinal Cord Stimulation for Treatment of Heart Failure with Preserved Ejection Fraction: Insight from a Porcine Model of Hypertensive Cardiomyopathy
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

List of Research Outputs

Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687..

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

CHENG Y., ZHAO J., Tse H.F., Le X.C. and Rong J., Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?, Oxidative Medicine and Cellular Longevity. 2015, 2015: 434052.

CHENG Y., ZHAO J., Tse H.F., Le X.C. and Rong J., Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction: a possible role for leukotriene B4 12-hydroxydehydrogenase?, 14th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Western University, London ON, Canada, August 18 - 20, 2015.

CHENG Y., Tse H.F., Xia Z. and Rong J., Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction: a possible role for leukotriene B4-12-hydroxydehydrogenase?, The 11th International Postgraduate Symposium on Chinese Medicine, Hong Kong Convention and Exhibition Center, Hong Kong, August 15, 2015.

Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Lip G.Y., Lam K.S.L., Tse H.F. and Siu D.C.W., Benefit of Anticoagulation Therapy in Hyperthyroidism-Related Atrial Fibrillation, Clin Cardiol. 2015, 38(8): 476-82.

Chan P.H.M., Lau C.P., Tse H.F., Chiang C.E. and Siu D.C.W., CHA2DS2-VASc Recalibration With an Additional Age Category (50-64 Years) Enhances Stroke Risk Stratification in Chinese Patients With Atrial Fibrillation, Canadian Journal of Cardiology. 2016.

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Chan P.H.M., Li W., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, European Heart Journal - Cardiovascular Pharmacotherapy. 2015, 1: 265-272.

Chan P.H.M., Li W.H.S., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Leung W.K., Hung F.N.I. and Siu D.C.W., Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22 (1); suppl 1: 11.

Chan P.H.M., Huang D., Yip P.S., Hai S.H.J.J., Tse H.F., Chan D.T.M., Lip G.Y., Lo W.K. and Siu D.C.W., Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis, Europace. 2016, 18(5): 665-71.

Chan P.H.M., Huang D., Lau C.P., Chan E.W., Wong I.C.K., Lip G.Y., Tse H.F. and Siu D.C.W., Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range, Can J Cardiol. 2016.

Chan P.H.M., Huang D., Hai S.H.J.J., Li W., Yin L.X., Chan E.W., Wong I.C.K., Lau C.P., Chiang C.E., Zhu J., Tse H.F. and Siu D.C.W., Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation, Heart Rhythm. 2016, 13(2): 366-73.

Chan P.H.M., Li W., Hai S.H.J.J., Chan E.W., Wong I.C.K., Tse H.F., Lip G.Y. and Siu D.C.W., Time in Therapeutic Range and Percentage of International Normalized Ratio in the Therapeutic Range as a Measure of Quality of Anticoagulation Control in Patients With Atrial Fibrillation, Can J Cardiol. 2015.

Chan P.H.M., Hai S.H.J.J., Chan E.W., Li W., Tse H.F., Wong I.C.K., Lip G.Y. and Siu D.C.W., Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence, PLoS One. 2016, 24;11(3): e0150674.

GAO F., Chiu S.M., Motan D.A.L., ZHANG Z., CHEN L., Ji H.O.N.G.-.L.I.N., Tse H.F., Fu Q.I.N.F.-.L.I.N.G. and Lian Q., Mesenchymal stem cells and immunomodulation: current status and future prospects, Cell Death and Disease. 2016, 7: e2062.

Hai S.H.J.J., Chan P.H.M., Huang D., Ho M.H., Ho C.W., Cheung E., Lau C.P., Tse H.F. and Siu D.C.W., Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population-The Hong Kong Heart Failure Registry, J Card Fail. 2016.

Hai S.H.J.J., Lim E.T., Chan C.P., Chan Y.S., Chan K.K., Chong D., Ho K.L., Tan B.Y., Teo W.S., Ching C.K. and Tse H.F., First clinical experience of the safety and feasibility of total subcutaneous implantable defibrillator in an Asian population, Europace. 2015, 17: Suppl 2:ii63-8.

Hai S.H.J.J. and Tse H.F., Phrenic nerve palsy in cryoballoon ablation: Can it be prevented? , Heart Rhythm. 2016, 13(2): 352-3.

Huang D., Chan P.H.M., Lam C.C., Shea P.C., Yiu K.H., Tse H.F. and Siu D.C.W., Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction, J Heart Valve Dis. 2015, 24(4): 433-5.

Kumana C.R., Cheung B.M.Y., Siu D.C.W., Tse H.F. and Lauder I.J., Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights, Cardiovascular Therapeutics. 2016, 34: 100-106.

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Lau C.P., Siu D.C.W., Yiu K.H., Lee K.L.F., Chan Y.H. and Tse H.F., Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices, Europace. 2015, 17: ii40-ii46.

Lee Y.K., Lau V.Y.M., Ng K.M., Lai K.W.H., Ho S.L., Tse H.F., Siu D.C.W. and Ho W.L., Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-Human Induced Pluripotent Stem Cell (hiPSC) as a drug Screening Platform for FRDA, International Journal of Cardiology. 2015.

Lian Q., Zhang Y., Liang X., Gao F. and Tse H.F., Directed Differentiation of Human-Induced Pluripotent Stem Cells to Mesenchymal Stem Cells, Methods Mol Biol. 2016, 1416: 289-98.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Liao S. and Tse H.F., Human iPSC-MSCs is superior to ESC-CMs for improvement of LV function in a porcine model of post-MI heart failure, ESC CONGRESS 2105. 2015.

Lip G.Y., Fauchier L., Freedman S.B., Van G.E.L.D.E.R., Natale A., Gianni C., Nattel S., Potpara T., Rienstra M., Tse H.F. and Lane D.A., Atrial fibrillation., Nat Rev Dis Primers. 2016, 2: 16016.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

Ng M.Y., Liu J., Mak H.K.F., Lau W.C.S., Tse H.F. and Yiu K.H., CT Calcium Score of Coronary Artery Calcification Progression in Rheumatoid Arthritis over a 10-year period and Risk Factors for Progression, European Congress of Radiology 2016.

Poon M.W., He J., Fang X., Zhang Z., Wang W., Wang J., Qiu F., Tse H.F., Li W., Liu Z. and Lian Q., Human ocular epithelial cells endogenously expressing SOX2 and OCT4 yield high efficiency of pluripotency reprogramming, PLOS One. 2015, 10(7): e0131288.

Sun Y., Zhang Y., Li X., Deng M., Gao W., Yao Y., CHIU S.M., LIANG X., GAO F., Chan C.W.Y., Tse H.F., Shi J., Fu Q. and Lian Q., Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice, STEM CELLS. 2015, n/a-n/a.

TSOI M.F., Cheung C.L., Cheung T.T., Wong I.C.K., Kumana C.R., Tse H.F. and Cheung B.M.Y., Duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of large randomised controlled trials, Scientific Reports. 2015, 5: 13204.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Tse H.F., 2015 Press Conference HKU Faculty Public Lecture promotion newspaper column.” HKU developed the atrial fibrillation (AF) management apps and Launch of HKU –private doctors AF screening programme, 2015.

Tse H.F., 2015 Press Conference HKU performs the first-in-man restorative treatment – the dual-targeted thoracic spinal cord stimulation for heart failure, 2015.

Tse H.F., AF3 Device detected and silent atrial fibrillation Remote Device monitoring: is there a mortality benefit? Does clinical practice reflect the studies? Emerging registry data, APHRS, Melbourne, Australia. 2015.

Tse H.F., Invited Speaker, 2016 Satellite Symposium New Insights to SPAF from Global to Asia, Taipei, Taiwan, 'Recent Advances in stroke Prevention in NVAF: The role of NOACS in Asia", 2016.

Tse H.F., Invited Speaker, ACC 2016, Chicago, United States "Increasing ICD Adoption in Asia: Current Status and Challenges", 2016.

Tse H.F., Invited Speaker, American Heart Association Scientific Sessions 2015, Orlando, USA, "Catheter based Radiofrequency Renal Denervation Decreases Renal Norepinephrine Spillover and Improve Cardiac Contractile Function in Porcine Model of Ischemic heart failure", 2015.

Tse H.F., Invited Speaker, Bayer Xarelto Forum: Anticoagulation and Non-Valvular AF: the Practice, the patient, Taipei & Kaohsiung, Taiwan,"The latest sights from real-life settings on the prevention of atrial fibrillation related strokes", 2016.

Tse H.F., Invited Speaker, China International Pacing Summit (CIPS) Haikou China 2016, " Multiple point coronary sins pacing. Case Sharing on devices", 2016.

Tse H.F., Invited Speaker, MACI Forum 2016 ,Macau "Novel Lipid Management", 2016.

Tse H.F., Invited Speaker, Meet The Masters 2015, Thailand, “SICD: Clinical Evidence and Programming Considerations, 2015.

Tse H.F., Invited Speaker, Oriental Congress of Cardiology, Shanghai, China 2016,"High Density mapping and ablation of atrial tachyarrhythmias Human Stem cell platform for modeling and drug testing of inherited cardiomyopathy, 2016.

Tse H.F., Invited Speaker, Seminar for CHCSJ Cardiologists in Macau 2016, "Cardio-protection of beta-blockers along CV continuum", 2016.

Tse H.F., Invited Speaker, VAS China, Nanjing, China 2016,'Clinical application of SICD", 2016.

Tse H.F., Invited Speaker, Venice Arrhythmia, Italy,"The Asia Pacific Heart Rhythm Society Guidelines, Upgrading from conventional PM to CRT: When and how (CRT-P vs CRT-D)", 2015.

Tse H.F., Invited Speaker,The 9th Heart Rhythm Forum of Jiangsu Province, Nanjing, China 2016 " 生理性起搏未來方向", 2016.

Tse H.F., Invited Speaker: NANS Tonic Versus Burst Mode of Spinal Cord Stimulation for Treatment of Ischemic Heart Failure, Las Vegas, United States 2015,"Topic versus burst mode of spinal cord stimulation for treatment of ischemic heart failure, 2015.

Tse H.F. and Schwartz P.J., Neural and spinal stimulation. In Ellenbogen KA, Wilkoff BL, Kay GN, Lau CP (eds): Clinical Cardiac Pacing, Defibrillation, and Resynchronization Therapy., Saunders Elsevier, Philadelphia, USA, 2016.. 2016, 5th Edition.

Tse H.F., Spotlight on Apixaban in NVAF: randomized clinical trial data and real-world experience, Stroke Prevention in NVAF: The Asian perspective., SPNVAF Masterclass June 2016, Singapore. 2016.

Tse H.F., The usuage of Rhythmia 3D mapping system is Atrial arrhythmia: Hong Kong Expereience, Ventricular Arrhythmia 2016. Taipei, Taiwan. 2016.

WANG Y., Liu H.H.L., Zhen Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Periodontitis links with EPC counts in patients with T2 diabetes, Journal of Dental Research. 2016, 95 (Spec Iss B): 587.

Yiu K.H., Ninaber M.K., Kroft L.J., Schouffoer A.A., Stolk J., Scherer H.U., Meijs J., de Vries B.O.U.W.S.T.R.A. .J., Tse H.F., Delgado V., Bax J.J., Huizinga T.W. and Marsan N.A., Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis., Rheumatology (Oxford).. 2016, 55: 504-12.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Zhang Y., ZHANG Z., GAO F., Tse H.F., Tergaonkar V. and Lian Q., Paracrine regulation in mesenchymal stem cells: the role of Rap1, Cell Death and Disease. 2015, 6: e1932.

Zhang Y., CHIU S.M., LIANG X., GAO F., ZHANG Z., Liao S., LIANG Y., Low D. .J. .H., Tse H.F., Lian Q. and Tergaonkar V., Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction, CELL DEATH DISCOVERY. 2015.

Researcher : Tse HM

List of Research Outputs

XU G., Ho W.L., Tse H.M., Ho S.L. and Leung K.M.Y., Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach, Environmental Pollution. 2016, 215: 103-112.

Researcher : Tso AWK

Project Title:	A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):	Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	12/2008

Project Title:	Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):	Tso AWK, Lam KSL, Chan DTM, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2009

List of Research Outputs

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Researcher : Tsoi SY

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Researcher : WANG B

List of Research Outputs

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Researcher : WANG L

List of Research Outputs

Zhang Q., WANG L., Wong K.Y., Li Z.Y. and Chim J.C.S., Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma, J Clin Pathol. 2015, 68(7): 557-561.

Researcher : WANG Y

List of Research Outputs

Lee Y.K.M., WANG Y., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators, Am J Physiol Cell Physiol. 2016, 310: C446-C455.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). 2016, 193: A7736.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Macrophage polarization plays a role in intermittent hypoxia (IH)-impaired subcutaneous adipogensis in an IH-exposed mouse model, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.): 51.

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Various Degrees Of Intensities Of Intermittent Hypoxia On Adipogenesis In Diet-Induced Obese Mouse Model, Am J Respir Crit Care Med. 2016, 193: A7736.

Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776.

Researcher : WONG WLD

List of Research Outputs

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : WU H

List of Research Outputs

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

WU H., Lo Y., LUK T.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function. International Lupus Congress, 2015. Clin Exp Rheumatol 2015;33 (Supp 90), 2015, S-21.

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. Annual Scientific meeting of the American College of Rheumatology 2015. Arthritis Rheum 2015, 2015.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : WU H

List of Research Outputs

Researcher : WU X

List of Research Outputs

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Researcher : Wang AYM

Project Title:	An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):	Wang AYM, Kwan CW, Lai KN
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	07/2008

Project Title:	Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):	Wang AYM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

List of Research Outputs

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

Researcher : Wang J

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Researcher : Wang J.

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Researcher : Wang Y

List of Research Outputs

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., International Trainee Scholarship Award for 2016 International Conference, American Thoracic Society (ATS). 2016, 193: A7736.

Researcher : Wen L

List of Research Outputs

Chan P.H.M., Wen L., Hai S.H.J.J., Chan K.H., Tse H.F., Cheung B.M.Y., Chan E.W., Wong I.C.K., Leung W.K., Hung F.N.I., Lip G.Y.H. and Siu D.C.W., Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control., Eur Heart J. . 2015, 1: 265-272.

Researcher : Wong B.C.Y.

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Researcher : Wong BCY

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Researcher : Wong CM

Project Title:	Coupling of nuclear RNA surveillance with splicing
Investigator(s):	Wong CM, Chen C
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	To study the role of mouse G-protein couple receptor GPR110 in the pathogenesis of obesity related medical complication
Investigator(s):	Wong CM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	05/2016

Project Title:	Deciphering the role of the long noncoding RNA Maternally Expressed 3 (MEG3) in hepatic lipid metabolism
Investigator(s):	Wong CM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015
Completion Date:	05/2016

Project Title:	Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of cholesterol metabolism
Investigator(s):	Wong CM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	05/2016

List of Research Outputs

CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6.

Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776.

Researcher : Wong DKH

Project Title:	Mutational analysis of the hepatitis B core protein DNA-binding domain and its role in HBV transcription regulation
Investigator(s):	Wong DKH, Huang FY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	11/2016

Project Title:	Hepatitis B X protein primary structure and epigenetic regulation of HBV replication
Investigator(s):	Wong DKH, Huang FY, Seto WKW, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in chronic hepatitis B patients who achieved undetectable serum HBV DNA while on long-term nucleoside analogue therapy. Oral presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 273A.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in patients with undetectable serum HBV DNA level while on nucleos(t)ide analogues, In: Masatoshi Kudo, The 6^th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2015), Evidence and Consensus on HCC Management, July 3-5, 2015, Osaka, Japan, Liver Cancer. Switzerland, S. Karger AG, 2015, 4 (Suppl 1): 162.

Cheung K.S.M., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HCC and serum markers in NA-treated patients with undetectable HBV DNA. Poster presentation P-0577, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S298.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W. and Yuen R.M.F., Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases:The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 963A.

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Fung J.Y.Y., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Long-term outcome of hepatitis b e-antigen seroclearance in chronic hepatitis B – results from the C.H.E.S.S. cohort. Poster presentation THU-125, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Supp 2): S363.

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development, Oncotarget. New York, Impact Journals, LLC, 2015, 6(33): 34941-52.

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., COLD-PCR for early detection of hepatitis B virus antiviral drug resistance mutations, Hong Kong Med J. 2015, Suppl 7: 8-10.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

Wong D.K.H., Young Investigator Award, The 25th Conference of the Asian Pacific Association for the Study of the Liver, Tokyo, Japan. 2016.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Researcher : Wong HYH

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Cheuk I., Lo J., Wong H.Y.H., Kwok G., Suen T.K.D., Chen T.H.C., Ma K.K., Chow L., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong, European Society for Medical Oncology Asia (ESMO ASIA) 2015 Congress (18-22 December, 2015). 2015.

Researcher : Wong KY

List of Research Outputs

Wong K.Y. and Chim J.C.S., DNA methylation of tumor suppressor protein-coding and non-coding genes in multiple myeloma, Epigenomics. 2015, in press.

Wong K.Y., LI Z., ZHANG X., Leung G.K.K., Chan G.C.F. and Chim J.C.S., Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma, Molecular Cancer. 2015, Epub on 2015-09-26.

Zhang Q., WANG L., Wong K.Y., Li Z.Y. and Chim J.C.S., Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma, J Clin Pathol. 2015, 68(7): 557-561.

Researcher : Wong LY

List of Research Outputs

LAW C.Y., Siu D.C.W., Fan K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Ho J.C.Y., Lee Y.K., Tse H.F. and Ng K.M., Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons, Biochemistry and Biophysics Reports. 2016, 5: 335-345.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Researcher : Wong LYF

Project Title:	Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Wong WLD

List of Research Outputs

Researcher : Wong WSR

List of Research Outputs

ZHANG J., ZHANG L., ZHANG Y., Yang J., GUO M., Sun L., Pan H.F., Hirankarn N., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W.G., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong W.S.R., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Cui Y., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations , Arthritis & Rheumatology. 2015, 67(11): 2966-77.

Researcher : Wong Y

List of Research Outputs

Lee A.C., Lam K.Y.J., Shiu S.W.M., Wong Y., Betteridge D.J. and Tan K.C.B., Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes., PLoS One. 2015, 10(9): e0137330.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Cholesterol efflux capacity in type 2 diabetic patients with advanced kidney disease., 23rd World Diabetes Congress, Vancouver, Dec 2015.. 2015.

Tan K.C.B., TSUN G.S., Shiu S.W.M. and Wong Y., Macrophage cholesterol efflux in type 2 diabetes mellitus., The Endocrine Society’s 98th Annual Meeting, Boston, Apr 2016.. 2016.

Researcher : Woo YC

List of Research Outputs

Cheung B.M.Y., Woo Y.C., Fong C.H.Y., Xu A. and Lam K.S.L., Blood level of fibroblast growth factor 21 and blood pressure. , Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Lang H.H.B., Yu H.W., Lo C.Y., Lee K.E., Garcia-Barcelo M.M., Woo Y.C., Lee C.H.P., Wong K.P., Tam P.K.H. and Lam K.S.L., Bilateral pheochromocytomas in MEN2A syndrome: a two-institution experience, World Journal of Surgery. 2015, 39(10): 2484-2491.

Lee C.H.P., Cheung C.Y., Chow W.S., Woo Y.C., Yeung C.Y., Lang H.H.B., Fong C.H., Kwok K.H., Chen S.P. and Mak C.M., Genetics of apparently sporadic pheochromocytomaand paraganglioma in a Chinese population, Hormone and Metabolic Research. 2015, Epub on 2015-08-12.

Lee C.H.P., Woo Y.C., Lam K.Y.J., Fong H.Y., Cheung B.M.Y., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese, Journal of Clinical Lipidology. 2015, 9: 640-646.e2.

Shih A.Z.L., Leung O.Y., Lee C.H., Fong C.H.Y., Woo Y.C., Cheung B.M.Y. and Lam K.S.L., Optimal cut-offs of homeostasis model assessment of insulin resistance to identify dysglycaemia and diabetes, Presented at the Medical Research Conference 2016, Hong Kong Medical Journal. 2016, 22(1); suppl 1: 47.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Researcher : Wu H

List of Research Outputs

Researcher : XU S

List of Research Outputs

Lam S.K., XU S. and Ho J.C.M., In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 30.

XU S., Lam S.K. and Ho J.C.M., The Effect of Arginase on Small Cell Lung Cancer, 21st Medical Research Conference. Hong Kong, Medical Journal, 2016, 22: 55.

Researcher : Xia HHX

Project Title:	Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Project Title:	Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2005

Researcher : Xiong J

Project Title:	2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):	Xiong J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2008

Researcher : Xu A

Project Title:	Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2007

Project Title:	Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2011

Project Title:	71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2011

Project Title:	The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
Investigator(s):	Xu A, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012
Completion Date:	12/2015

Project Title:	The adaptor protein APPL1 as a physiological regulator of insulin secretion in pancreatic βcells
Investigator(s):	Xu A, Cheng KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Adipocyte fatty acid binding protein as a mediator of obesity-related medical complications
Investigator(s):	Xu A, Hoo RLC
Department:	Medicine
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2014

Project Title:	Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain
Investigator(s):	Xu A, Cheng KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes
Investigator(s):	Xu A, Lam KSL, Chan YCC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	04/2015

Project Title:	Neutrophil-derived proteinase 3 as a new player in the pathogenesis of obesity-induced non-alcoholic steatohepatitis
Investigator(s):	Xu A, Ye D
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	2015 51st EASD Annual Meeting ; Adiponectin is required for adaptive thermogenesis by enhancing the browning of white adipose tissues in mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015

Project Title:	Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2015

Project Title:	Frontiers in Immunometabolism
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	11/2015

Project Title:	Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Brown adipose tissue as a new weapon against obesity-related vascular disorders
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis
Investigator(s):	Xu A, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	FGF21 as a potential mediator for the anti-depressant effects of physical exercise
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism
Investigator(s):	Xu A, Woo WHC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

List of Research Outputs

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Vascular responses in ageing: effects of obesity and/or constitutive activation of adenosine monophosphate-activated protein kinase (CA-AMPK), a TCM target, in endothelial cells, The 11th International Postgraduate Symposium on Chinese Medicine, August 14, 2015, Hong Kong. 2015.

Bai B., MAN W.C., YANG K., Guo Y., Xu C., Tse H.F., Han W., Bloksgaard M., De Mey J.G., Vanhoutte P.M.G.R., Xu A. and Wang Y., Endothelial SIRT1 prevents arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. , Oncotarget. 2016, doi: 10.18632/oncotarget.9687..

CAI Y., YING F., SONG E., Wang Y., Xu A., Vanhoutte P.M.G.R. and Tang E.H.C., Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance, The FASEB Journal. 2015, 29: 4924-4936.

Cai Y., Sukhova G.K., WONG H.K., Xu A., Tergaonkar V., Vanhoutte P.M.G.R. and Tang E.H.C., Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions, Cell Cycle. 2015, 14: 3580-3592.

Chan S.M.H., Zeng X.Y., Sun R.Q., Jo E., Zhou X., Wang H., Li S., Xu A., Watt M.J. and Ye J.M., Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2015, 1852(7): 1511-1519.

Cheung B.M.Y., Woo Y.C., Fong C.H.Y., Xu A. and Lam K.S.L., Blood level of fibroblast growth factor 21 and blood pressure. , Presented at the 21st Medical Research Conference, 2016 Hong Kong. Hong Kong Med J 2016. 22(1) suppl 1: 16.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Biased Activation of Soluble Guanylyl Cyclase Can Cause Contraction of Isolated Arteries, Experimental Biology 2016, San Diego, California, U.S.A. FASEB J, 2016, 30.

Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced clusterin (ApoJ) content of low density lipoproteins contribute to endothelial dysfunction in adiponectin-deficient mice, 83rd European Atherosclerosis Society Congress. ELSEVIER, 2015, 16(S2).

Dong Z., Su L., Esmaili S., Iseli T.J., Ramezani-Moghadam M., Hu L., Xu A., George J. and Wang J., Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells, Journal of Molecular Medicine. 2015.

GUO Y., WANG L., Huang M., LEE I., Xu A. and Wang Y., Overexpression of SIRT1 in Adipose tissue Induces Clusterin-mediated Beneficial Metabolic Effects on Adiponectin Knockout Mice during Obesity, 76th Scientific sessions New Orleans, LA, June 10-14, 2016.

Guo Y., Xu A. and Wang Y., SIRT1 in endothelial cells as a novel target for the prevention of early vascular ageing, Journal of Cardiovascular Pharmacology. 2016, 67: 465-73.

Hoo R.L.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) potentiates toxic lipids-induced endoplasmic reticulum stress and inflammation in macrophages via inhibition of Janus Kinase 2-dependent autophagy, 脂肪细胞型脂肪酸结合蛋白（A-FABP）在毒性脂质诱导的巨噬细胞炎症反应中的作用机制研究, 广东省继续医学教育项目 “血液净化临床技术的进展与应用”学习班《两岸三地粤港澳台学者研讨会, 2015.

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

Hui X. and Xu A., The FGF21–adiponectin axis in controlling energy and vascular homeostasis, J Mol Cell Biol. 2016, 8: 110.

KWOK H.M., Lam K.S.L. and Xu A., Heterogeneity of white adipose tissue: molecular basis and clinical implications, Experimental & Molecular Medicine. 2016, 48: e215.

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Kim A.Y., Park Y.J., Pan X., Shin K.C., Kwak S.H., Bassas A.F., Sallam R.M., Park K.S., Alfadda A.A. and Xu A., Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance, Nature Communications. 2015, 6: 7585.

LI J., Lin S., Vanhoutte P.M.G.R., Woo W.H.C. and Xu A., Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice , Circulation. 2016, 133: 2434-2446.

Li A., Xu A., Zhou L. and So K.F., 运动干预神经精神疾病的整合生物学研究与中国“脑计划”, SCIENTIA SINICA Vitae. SCIENCE CHINA PRESS, 2015, 46 (2): 216-217.

Li C., Ling C., Shao Y., Xu A., Li X.C., Ng K.T.P., Liu X., Ma Y.Y., Qi X., LIU H., LIU J., Yeung W.H., Yang X., Liu Q., Lam Y.F., Zhai Y., Lo C.M. and Man K., CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation, Journal of Hepatology. 2016, 65(5): 944-952.

Li H., Yao W., LIU Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats, Diabetes. 2016, 65: 942-955.

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

SHU L., WU X., PAN Y., LEE P.C., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein Mediates Adaptive Thermogenesis via Inducing Intracellular Conversion of Thyroid Hormones , 13th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC). 2015.

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.

Vanhoutte P.M.G.R., Zhao Y., Xu A. and Leung S.W.S., Thirty Years of Saying NO, Circulation Research. 2016, 119: 375-396.

Woo W.H.C., CHEN J., LI J., YIU J.H.C. and Xu A., Metabolic Function of Toll like Receptor mediated by TRIF, In: Federation of American Societies for Experimental Biology, FASEB Summer Research Conference 2015, Nutritional Immunology: Role in Health and Disease. 2015.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Fibroblast Growth Factor 21 As a Biomarker Is Superior to Adiponectin in the Prediction of Incident Diabetes, Endocrine Society Annual Scientific Meeting, Boston, USA, Mar 31 - Apr 2016.

Xu A., Croucher Senior Researcher fellowship award, Croucher Foundation. 2016.

YANG K., Luo C., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 Deficiency Protects against Aldosterone-Induced Hypertension and Organ Damages by Inhibiting Mineralocorticoid Receptor Signaling, Experimental Biology 2016, San Diego, April 2-6, 2016.

YANG K., Luo C., Bai B., Cheung B.M.Y., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Mice Deficient with Lipocalin-2 are Protected from Both Angiotensin-II and Aldosterone-induced Cardiac and Renal Fibrosis, Experimental Biology 2016, San Diego, April 2-6, 2016.

YIU J.H.C., LI J., Xu A. and Woo W.H.C., Involvement of Toll-Like Receptor 5 Pathway in Hepatic Lipid Export, In: AAAS/Science Translational Medicine, IPSEN, HKU, Bridging Biomedical Worlds: Frontiers in Human Microbiota Symbiotic Interactions. 2016.

YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis by Toll-like Receptor 5 Pathway, Keystone Symposium on Molecular and Cellular Biology, Banff, Alberta, Canada, February 15-19, 2016.

YIU J.H.C., LI J., Xu A. and Woo W.H.C., Regulation of Adipogenesis in Visceral Adipose Tissue by Toll-like Receptor 5 Pathway, In: Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong , 11th International Symposium on Healthy Aging. 2016.

Yan C.H., LI T., ZHANG C., Xu A. and Chiu P.K.Y., Basic Science Award, 35th Hong Kong Orthopaedic Association Annual Congress, Hong Kong Orthopaedic Association. 2015.

Yan C.H., ZHANG C., LI T., Xu A. and Chiu P.K.Y., Fatty acid binding protein-4 as a biomarker in knee osteoarthritis, 36th Annual Congress of The Hong Kong Orthopaedic Association, Hong Kong. 2015.

Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776.

Ye D., Yang K.A.N.G.M.I.N., Chau H.A.U. .T.A.K., Xu A. and Wang Y., Lipocalin-2 Mediates Nonalcoholic Steatohepatitis by Promoting Neutrophil-Macrophage Crosstalk via The Induction of CXCR2, In: Rajiv Jalan, Journal of Hepatology. 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction, Clinical Science. 2015, 129(7): 547-559.

Researcher : YU H

List of Research Outputs

YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Inhibition Impairments in Temporal Lobe Epilepsy (TLE) Patients: Electroencephalography (EEG) Evidence from a Go/Nogo Study, 21st Medical Research Conference (HKU) . 2016, 60.

Researcher : Yam IYL

List of Research Outputs

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Yap YHD

Project Title:	A Therapeutic Drug Monitoring Program of Mycophenolic Acid in patients with Lupus Nephrities
Investigator(s):	Yap YHD
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2013

Project Title:	Relationship between Mycophenolic Acid Pharmacokinetics and Pharmacogenomics with treatment response and disease activity in lupus nephritis
Investigator(s):	Yap YHD, Ma KMM, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Lymphocyte subset profile and clinical phenotype in lupus nephritis
Investigator(s):	Yap YHD, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Chan G.C., Lam B., Yap Y.H.D., Ip M.S.M., Lai K.N. and Tang S.C.W., Proteinuria is associated with sleep apnea in chronic kidney disease., Nephrol Dial Transplant. 2016, 31(5): 772-9.

Chan K.Y., Yip T., Yap Y.H.D., Sham M.K., Wong Y.C., Lau W.K., Li C.W., Cheng H.W., Lo W.K. and Chan D.T.M., Enhanced Psychosocial Support for Caregiver Burden for Patients With Chronic Kidney Failure Choosing Not to Be Treated by Dialysis or Transplantation: A Pilot Randomized Controlled Trial, American Journal of Kidney Diseases. 2016, 67(4): 585-92.

Cheung K.C., Chan K.Y. and Yap Y.H.D., Disenfranchised Grief after the Death of a Palliative Care Colleague, J Palliat Med. 2016.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Yap Y.H.D., Tse H., Mok M.M., Chan G.C., Yip T., Lui S.L., Lo W.K. and Chan D.T.M., Arthrobacter sanguinis: an uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2015, 20(11): 868.

Yap Y.H.D., Best Oral Abstract Presentation - 21st Medical Research Conference, Department of Medicine, The University of Hong Kong, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. 2016.

Yap Y.H.D., Mok M.M., Chan G.C., Choy B.Y. and Chan D.T.M., Kidney Allograft Abscess: An Unusual Cause of Peritonitis in a Patient on Peritoneal Dialysis, Nephrology (Carlton). 2016, 21(3): 266.

Yap Y.H.D. and Chan D.T.M., Lupus Nephritis in Asia: Clinical Features and Management, Kidney Diseases. 2015, 1(2): 100-109.

Yap Y.H.D., Management of viral infections after kidney transplantation, Management of viral infections after kidney transplantation - Macau Society of Nephrology. 2016.

Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang C. and Chan D.T.M., Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis, Lupus. 2016, 25(1): 46-53.

Yap Y.H.D., Use of anti-viral treatment in renal transplant recipients with chronic hepatitis B infections, Cross Strait China, Hong Kong and Taiwan Chronic Hepatitis B Forum. 2015.

Yap Y.H.D., Use of erythropoietin-stimulating agents in dialysis patients. , Macau Society of Nephrology. 2016.

Yap Y.H.D. and Chan D.T.M., Use of telbivudine in kidney transplant recipients with chronic hepatitis B virus infection: A preliminary experience., Nephrology (Carlton). 2016, 21(5): 438-41.

Researcher : Yau TCC

Project Title:	The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):	Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:	Surgery
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	A Pilot Study to Evaluate the Prophylactic Effects of Telbivudine for Prevention of Hepatitis B Reactivation in HBsAg Positive Patients Receiving Sorafenib Treatment for Advanced Hepatocellular Carcinoma
Investigator(s):	Yau TCC, Poon RTP
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases
Investigator(s):	Yau TCC
Department:	Surgery
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients
Investigator(s):	Yau TCC, Poon RTP
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	A Phase II study of the safety and efficacy of PEG-BCT-100 combined with capecitabine/oxaliplatin in patients with advanced hepatocellular carcinoma (Part I)
Investigator(s):	Yau TCC
Department:	Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	04/2014

Project Title:	Randomized Phase II Trial of Sorafenib, Capecitabine and Oxaliplatin (SECOX) versus Single Agent Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Investigator(s):	Yau TCC, Poon RTP
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	04/2015

Project Title:	A Prospective Validation of the Hong Kong Liver Cancer (HKLC) Prognostic Staging System: A Multi-Centre Study in Hong Kong
Investigator(s):	Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Cheuk I., Lo J., Wong H.Y.H., Kwok G., Suen T.K.D., Chen T.H.C., Ma K.K., Chow L., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong, European Society for Medical Oncology Asia (ESMO ASIA) 2015 Congress (18-22 December, 2015). 2015.

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk I., Lo J., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Intensifying taxane-carboplatin-containing neoadjuvant chemotherapy (NAC) increased response in locally advanced HER2-positive breast cancer patients with hormone receptor expression, Global Breast Cancer Conference (GBCC) 2015 (28-30 April 2016). 2016.

Chow K.M., Yau T.C.C., Ng L., Chu A.C., Law W.L., Poon R.T.P. and Pang R.W.C., A preclinical study on the combination therapy of everolimus and transarterial chemoembolization in hepatocellular carcinoma, American Journal of Cancer Research. 2015, 5: 2376-2386.

Kang Y.K., Yau T.C.C., Park J.W., Lim H.Y., Lee T.Y., Obi S., Chan S.L., Qin S., Kim R.D., Casey M., Chen C., Bhattacharyya H., Williams J.A., Valota O., Chakrabarti D. and Kudo M., Randomised phase II study of axitinib versus placebo plus best supportive care in second-line treatment of advanced hepatocellular carcinoma, Annals of Oncology. 2015.

Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.

Yau T.C.C., Epidemiology and Standard of care for Colorectal Cancer in Asia Pacific, Expert Input Forum for Pembrolizumab(Biomarker Development), Tokyo, Japan. 2015.

Yau T.C.C., Examining the Current evidence for Treatment of NET: Clinical Insights, Philippine Society of Medical Oncology Annual Conference 2015, Manila, Philippine . 2015.

Yau T.C.C., Hepatocellular Carcinoma: Why aren’t We Making Progress with Systemic Treatment and What is the role of Ablative Strategies?, ESMO Asia 2015, Singapore. 2015.

Yau T.C.C., Hong Kong Liver Cancer Classification, The 7th Annual meeting of Asia Pacific Alliance of Liver Diseases, Qingdao, China. 2015.

Yau T.C.C., Hong Kong Liver Cancer Staging System, 2015 Seoul Liver Symposium, Seoul National University, Seoul, South Korea . 2015.

Yau T.C.C., New Perspectives in Cancer Therapy - Immunotherapy, Macau Oncology Association, Macau. 2015.

Yau T.C.C., Optimizing mCRC treatment with Regorafnib: Personalised Dosing and AE management, Macau Oncology Association, Macau . 2015.

Yau T.C.C., Staging of Hepatocellular Carcinoma: Hong Kong vs Barcelona, 28th Annual Scientific Meeting, Hong Kong Association for the Study of Liver Diseases, Hong Kong . 2015.

Yau T.C.C., Targeted Therapy in the Management of Advanced Colorectal Cancer, Novartis APECHO Meeting, Taipei, Taiwan . 2015.

Yau T.C.C., Treatment stratification for patients with hepatocellular carcinoma according to HCC stage, Asian Pacific Digestive Week 2015, Taipei, Taiwan . 2015.

Yau T.C.C., Chiu W.Y.J. and Cheung T.T., What determines treatment success and future perspectives?, Postgraduate Medical Journal. 2016, 92(1085): 123-124.

Yip V.S.K., Cheung T.T., Poon R.T.P., Yau T.C.C., Fung J.Y.Y., Dai W.C., Chan A.C.Y., Chok K.S.H., Chan S.C. and Lo C.M., Does hepatitis B seroconversion affect survival outcome in patients with hepatitis B related hepatocellular carcinoma?, Translational Gastroenterology and Hepatology. 2016, 1: 51.

Researcher : Ye D

Project Title:	Lipocalin-2 in acute and chronic liver diseases: focusing on neutrophil-mediated innate immune responses
Investigator(s):	Ye D, Wang Y, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013

Project Title:	Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota
Investigator(s):	Ye D
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Local Adipose Tissue Inflammation Promotes Atherosclerosis Development through a JNK-AFABP Axis, 4th International Congress on Lipid Metabolism and Atherosclerosis. 2015.

Ye D., Li H., Wang Y., Jia W., Zhou J., Fan J., Man K., Lo C.M., Wong C.M., Wang Y., Lam K.S.L. and Xu A., Circulating fibroblast growth factor 21 Is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation, Scientific Reports. 2016, 6: 19776.

Ye D., Yang K.A.N.G.M.I.N., Chau H.A.U. .T.A.K., Xu A. and Wang Y., Lipocalin-2 Mediates Nonalcoholic Steatohepatitis by Promoting Neutrophil-Macrophage Crosstalk via The Induction of CXCR2, In: Rajiv Jalan, Journal of Hepatology. 2016.

Researcher : Yeung CK

Project Title:	*HLA-B 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong**
Investigator(s):	Yeung CK, Tang SCW, Cheung BMY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2012

Researcher : Yeung CY

List of Research Outputs

Lee C.H.P., Cheung C.Y., Chow W.S., Woo Y.C., Yeung C.Y., Lang H.H.B., Fong C.H., Kwok K.H., Chen S.P. and Mak C.M., Genetics of apparently sporadic pheochromocytomaand paraganglioma in a Chinese population, Hormone and Metabolic Research. 2015, Epub on 2015-08-12.

Researcher : Yim RLH

List of Research Outputs

Singh G.H.H., Ip H.W., Li J., Yim R.L.H., Panagiotou I., Leung A.Y.H. and Kwong Y.L., Whole exome sequencing identifies novel mutations in relapsed or refractory acute promyelocytic leukaemia failing treatment with oral arsenic trioxide, 21st Congress of the European Hematology Association. Haematologica, 2016.

Researcher : Yip TPS

List of Research Outputs

Shea Y.F., Lam M.F., Lee M.S., Mok M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of Cognitive Impairment Among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis, Peritoneal Dialysis International. 2016, 36(3): 284-290.

Researcher : Yip WKG

List of Research Outputs

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Researcher : Yiu KH

Project Title:	Relationship between matrix G1a protein and osteogenic endothelial progenitor cells with vascular and valvular calcification in patients with rheumatoid arthritis: Potential therapeutic role of vitamin K
Investigator(s):	Yiu KH, Lau WCS, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Investigator(s):	Yiu KH, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Huang D., Chan P.H.M., Lam C.C., Shea P.C., Yiu K.H., Tse H.F. and Siu D.C.W., Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction, J Heart Valve Dis. 2015, 24(4): 433-5.

Jim M.H., Wu E.B., Fung R.C., Ng A.K., Yiu K.H., Siu D.C.W. and Ho H.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Heart Vessels.. 2015, 30(4): 427-431.

Lau C.P., Siu D.C.W., Yiu K.H., Lee K.L.F., Chan Y.H. and Tse H.F., Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices, Europace. 2015, 17: ii40-ii46.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

Ng M.Y., Liu J., Mak H.K.F., Lau W.C.S., Tse H.F. and Yiu K.H., CT Calcium Score of Coronary Artery Calcification Progression in Rheumatoid Arthritis over a 10-year period and Risk Factors for Progression, European Congress of Radiology 2016.

WANG Y., Liu H.H.L., Zhen Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Periodontitis links with EPC counts in patients with T2 diabetes, Journal of Dental Research. 2016, 95 (Spec Iss B): 587.

Yiu K.H., Ninaber M.K., Kroft L.J., Schouffoer A.A., Stolk J., Scherer H.U., Meijs J., de Vries B.O.U.W.S.T.R.A. .J., Tse H.F., Delgado V., Bax J.J., Huizinga T.W. and Marsan N.A., Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis., Rheumatology (Oxford).. 2016, 55: 504-12.

Yiu K.H., Invited Speaker, APHRS Cardiac Rhythm Device Therapy Module Heart Failure and Basics of CRT Virtual Reality and Programming Workshop 2015, “ Heart Failure and basics of CRT”, 2015.

Yiu K.H., Invited Speaker, European Society of Cardiology 2015,”Relationship of extracellular matrix regulation, collagen turnover and renin angiotensin system activity with myocardial function in patients with type 2 diabetes mellitus, 2015.

Yiu K.H., Invited Speaker, Health Exhibition 2015, 2015.

Yiu K.H., Invited Speaker,Society of Physicians Sunday Symposium Diabetic cardiomyopathy- Diagnosis and management, 2016.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : Yiu WH

Project Title:	ASN Kidney Week 2013 Annual Meeting ; Tissue Kallikrein Mediates Pro-inflammatory Pathways in Proximal Tubular Epithelial Cells
Investigator(s):	Yiu WH
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2013

List of Research Outputs

Chan G.C.W., Yiu W.H., Wu H., Wong W.L.D., Lin M., Huang X.R., Lan H.Y. and Tang S.C.W., N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice, Mediators Inflamm. 2015, 2015: 283123.

WONG W.L.D., Yiu W.H., WU H., LI R., Liu Y., CHAN K.W., Leung J.C.K., Chan L.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, American Journal of Nephrology. 2016, 26: 728A.

Wong W.L.D., Yiu W.H., Wu H., Li R., Liu Y., Chan K.W., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Downregulation of renal tubular Wnt/beta-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy, Cell Death Dis. 2016, 7: e2155.

Yiu W.H., WONG W.L.D., WU H., LI R., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin Protects Against Diabetic Nephropathy In Db/db Mice By Suppressing Age-rage-induced Oxidative Stress, J Am Soc Nephrol. 2015, 26: 169A.

Yiu W.H., Wong W.L.D., Wu H., Li R., Yam I.Y.L., Chan Y.Y., Leung J.C.K., Lan H.Y., Lai K.N. and Tang S.C.W., Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress, Kidney Int. 2015, doi: 10.1038/ki.2015.331.

Researcher : Yuen JCH

List of Research Outputs

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Researcher : Yuen MAM

List of Research Outputs

Lam K.S.L., Woo Y.C., Yuen M.A.M., Fong H.Y., Tso A.W.K. and Cheung B.M.Y., Obesity indices versus 2-hour plasma glucose for predicting incident diabetes in a 16-year prospective study of Hong Kong Chinese, 76th Scientific Sessions of the American Diabetes Association. 2016.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

Woo Y.C., Loong C.H., Chau W.K., Lam K.Y.J., Yuen M.A.M., Lee C.H.P., Lee A.C. and Tan K.C.B., Effect of denosumab on bone mineral density in patients with prior bisphosphonate exposure., 16th World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Malaga, Apr 2016.. 2016.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : Yuen MF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

Researcher : Yuen RMF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Effect of the hepatitis B core protein c-terminal domain mutations on HBV transcription. Poster presentation THU-181, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S386.

Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Prevention and management of hepatitis B virus reactivation in cancer patients, Hepatology International. 2016, 10(3): 407-414.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in chronic hepatitis B patients who achieved undetectable serum HBV DNA while on long-term nucleoside analogue therapy. Oral presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 273A.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Relationship between hepatocellular carcinoma development and serum viral markers in patients with undetectable serum HBV DNA level while on nucleos(t)ide analogues, In: Masatoshi Kudo, The 6^th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2015), Evidence and Consensus on HCC Management, July 3-5, 2015, Osaka, Japan, Liver Cancer. Switzerland, S. Karger AG, 2015, 4 (Suppl 1): 162.

Cheung K.S.M., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HCC and serum markers in NA-treated patients with undetectable HBV DNA. Poster presentation P-0577, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S298.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W. and Yuen R.M.F., Associated with the Development of Hepatocellular Carcinoma after HBeAg Seroclearance. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases:The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 963A.

Fung J.Y.Y., Seto W.K.W., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Corrigendum to “Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy” [J Hepatol 2011;54:195–200], Journal of Hepatology. 2016, 64(6): 1460.

Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Emerging drugs for the treatment of hepatitis B, Expert Opinion on Emerging Drugs. 2016, 21(2): 183-193.

Fung J.Y.Y., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Long-term outcome of hepatitis b e-antigen seroclearance in chronic hepatitis B – results from the C.H.E.S.S. cohort. Poster presentation THU-125, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Supp 2): S363.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Wong C.L.T., Sharr W.W., Cheung T.T., Chan A.C.Y., Dai W.C., Sin S.L., Ng I.O.L., Lai C.L., Yuen R.M.F. and Lo C.M., Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone, Liver Transplantation. 2015, 21(12): 1504-10.

Goel A., Eapen C.E., Choudhary A., Sharma M.K., Maiwall R., Al Mahtab M., Chawla Y.K., Tan S.S., Ning Q., Devarbhavi H., Amrapurkar D.N., Kim C.W., Hamid S.S., Butt A.S., Ghazinyan H., Duan Z., Yu C., Sood A., Lee G.H., Abbas Z., Shiha G., Lesmana L.A., Payawal D.A., Dokmeci A.K., Yuen R.M.F., Lau G.K., Karim M.F., Sollano J.D., Sarin S.K. and APASL-ACLF W.O.R.K.I.N.G. .P.A., Better survival in patients with hepatitis e virus c.f. to other acute insults causing acute-on-chronic liver failure (ACLF) – APASL-ACLF research consortium (AARC) database. Poster presentation THU-107., The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016. 64(Suppl 2): S355-6.

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development, Oncotarget. New York, Impact Journals, LLC, 2015, 6(33): 34941-52.

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Seto W.K.W., Cho C.H., Lai C.L. and Yuen R.M.F., Interleukin-1b increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model., Oncol Lett. Greece, Spandidos Publications, 2016, 11(4): 2919-2924.

Huang F.Y., Wong D.K.H., Seto W.K.W., Zhang A.Y., Lee C.K., Lin C.K., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Chan A.O.O., Sequence Variations of Full-length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-negative Hepatitis B Infection , Oral presentation at the 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. London, Spandidos Publications, 2015, 36, Supplement 1: S21.

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.

Kim Y.A., Estevez J., Le A., Israelski D., Baatarkhuu O., Sarantuya T., Narantsetseg S., Nymadawa P., Le H., Yuen R.M.F., Dusheiko G., Rizzetto M. and Nguyen H., Low liver disease screening and treatment rates in Mongolia: results from a physician survey. Poster presentation P-0307, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International 2016. 10 (Suppl 1): S208-9.

Lai C.L., Wong V.W.S., Yuen R.M.F., Yang J.C., Knox S.J., Mo H., Han L.L., Brainard D.M. and Chan H.L.Y., Sofosbuvir plus ribavirin for the treatment of patients with chronic genotype 1 or 6 hepatitis C virus infection in Hong Kong, Alimentary Pharmacology & Therapeutics. 2016, 43(1): 96-101.

Lam P.Y., Cheung F., TAN H.Y., Wang N., Yuen R.M.F. and Feng Y., Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities, International Journal of Molecular Sciences. 2016, 17: 465.

Lam W.W.T., Liao Q., Wong J.H.F., Lai C.L., Yuen R.M.F., Tsang J.W.H. and Fielding R., Measuring and validating a general cancer predisposition perception scale: an adaptation of the revised-IPQ-genetic predisposition scale, PLoS One. 2015, 10: e0142620.

Lee G.H., Tun T., Lim S.G., Choudhury A., Hamid S., Abbas Z., Amarapurkar D., Chawla Y.K., Dokmeci A.K., Ghazinyan H., Kim D.J., Tan S.S., Ning Q., Lesmana L.A., Mahtab M., Komolmit P., Yuen R.M.F., Yokosuka O., Moreau R. and Sarin S.K., Liver transplantation for patients with acute-on-chronic liver failure in Asia. Poster presentation P-0213, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International 2016. 10 (Suppl 1): S177-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Mak L.Y.L., Ko K.L.M., Lai C.L. and Yuen R.M.F., A population-based study on the seroprevalence of viral hepatitis in Hong Kong, China. Poster presentation P-0305, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): :S207-8.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S.M., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis b virus in the general population after universal hepatitis B immunization era in Hong Kong, China. Poster presentation THU-162, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S378.

Liu S.H.K., Seto W.K.W., Seto W.K.W. and Yuen R.M.F., Hepatitis B: treatment choice and monitoring for response and resistance, Expert Review of Gastroenterology & Hepatology. 2016, 10(6): 697-707.

Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., DNA polymerase inhibitors for treating hepatitis B: a safety evaluation, Expert Opinion on Drug Safety. 2016, 15(3): 383-392.

Poh Z., Shen L., Yang H.I., Seto W.K.W., Wong V.W., Lin C.Y., Goh B.B., Chang P.E., Chan H.L.Y., Yuen R.M.F., Chen C.J. and Tan C.K., Real-world risk score for hepatocellular carcinoma (RWS-HCC): a clinically practical risk predictor for HCC in chronic hepatitis B, Gut. 2016, 65(5): 887-888.

Sarin S.K., Kumar M., Lau G.K., Abbas Z., Chan H.L.Y., Chen C.J., Chen D.S., Chen H.L., Chen P.J., Chien R.N., Dokmeci A.K., Gane E.D., Hou J.L., Jafri W., Jia J., Kim J.H., Lai C.L., Lee H.C., Lim S.G., Liu C.J., Locarnini S., Al Mahtab M., Mohamed R., Omata M., Park J., Piratvisuth T., Sharma B.C., Sollano J., Wang F.S., Wei L., Yuen R.M.F., Zheng S.S. and Kao J.H., Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update, Hepatology International. 2016, 10(1): 1-98.

Seto W.K.W., Cheung K.S.M., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Leung W.K., Lai C.L. and Yuen R.M.F., Determinants for persistent fibrosis during nucleoside analogue therapy in chronic hepatitis B. Poster presentation P-0398, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan.. Hepatology International. 2016, 10 (Suppl 1): S239.

Seto W.K.W., Cheung K.S., Wong D.K.H., Huang F.Y., Fung J.Y.Y., Liu S.H.K., Lai C.L. and Yuen R.M.F., Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability, Journal of Gastroenterology. 2016, 51(5): 487-495.

Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance, Liver International. 2016, 36(5): 642-650.

Seto W.K.W., Wong D.K.H., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., The role of hepatitis B core-related antigen in predicting HBV reactivation among HBsAg-negative, anti-HBc-positive individuals undergoing immunosuppressive therapy. Poster presentation, 66^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. Hepatology. 2015, 62(Suppl 1): 966A.

TAN H.Y., Wang N., Tsao G.S.W., Che C.M., Yuen R.M.F. and Feng Y., IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma, Oncotarget. 2016.

Wang N., XU Q., TAN H.Y., HONG M., LI S., Yuen R.M.F. and Feng Y., Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells, Evidence-Based Complementary and Alternative Medicine. 2016, 2016: 1-11.

Wang N., TAN H.Y., LI L., Yuen R.M.F. and Feng Y., Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives, Journal of Ethnopharmacology. 2015, 176: 35-48.

Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., COLD-PCR for early detection of hepatitis B virus antiviral drug resistance mutations, Hong Kong Med J. 2015, Suppl 7: 8-10.

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

Wong D.K.H., Seto W.K.W., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Oral Presentation O-097, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan, Hepatology International. 2016, 10 (Suppl 1): S42.

Wong D.K.H., Fung J.Y.Y., Lee C.K., Seto W.K.W., Leung J., Huang F.Y., Lin C.K., Lai C.L. and Yuen R.M.F., Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection, Clinical Microbiology and Infection. 2016, 22(3): 290.e1-290.e3.

Yuen R.M.F., Anti-viral therapy in hepatitis B virus reactivation with acute-on-chronic liver failure, Hepatology International. 2015, 9: 373-377.

Yuen R.M.F., Antiviral therapy in hepatitis B virus reactivation with acute on chronic liver failure, Hepatology International. 2015, 9(3): 373-7.

Yuen R.M.F., Associate Editor, Hepatology International. 2015.

Yuen R.M.F., Associate Editor, Journal of Clinical and Translational Hepatology. 2015.

Yuen R.M.F., CHB: current guidelines and long-term benefits, National Training on Liver Diseases: Diagnosis, Linkage to Care, Treatment and Monitoring, Ulan Bataar, Mongolia, 21-22 September. 2015.

Yuen R.M.F., Ahn S.H., Chen D.S., Chen P.J., Dusheiko G.M., Hou J.L., Maddrey W.C., Mizokami M., Seto W.K.W., Zoulim F. and Lai C.L., Chronic Hepatitis B Virus Infection, Journal of Clinical Gastroenterology. 2016, 50(4): 286-294.

Yuen R.M.F., Chronic hepatitis B: whom to screen, how to evaluate, whom to treat, National Training on Liver Diseases: Diagnosis, Linkage to Care, Treatment and Monitoring, Ulan Bataar, Mongolia, 21-22 September. 2015.

Yuen R.M.F., Clinical implication of occult hepatitis B., 25^th Confrence of the Asian Pacific Association for the Study of the Liver, Tokyo, Japan, 20-24^th February 2016. 2016.

Yuen R.M.F., Cureent advancement on hepatitis C treatment, Society of Hospital Pharmacists of Hong Kong, 28 August, 2015, Hong Kong. 2015.

Yuen R.M.F., Current advancement on hepatitis C treatment, Annual Scientific Meeting, Macau Society of Gastroenterology and Hepatology, Macau, 18-19 July. 2015.

Yuen R.M.F., Current state of hepatitis B in Asia., 5^th Annual Asia Hepatology Perspective Forum, Hong Kong 19-20^th December 2015. 2015.

Yuen R.M.F., Chan H.L.Y., Given B.D., Schluep T., Hamilton J., Locarnini S.A., Lau J.Y.N., Ferrari C. and Gish R.G., Differential reductions in viral antigens expressed from cccDNAVS integrated DNA in treatment naïve HBeAg positive and negative patients with chronic HBV after RNA interference therapy with ARC-520. Poster presentation THU-193, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016. 64(Suppl 2): S390.

Yuen R.M.F., Early Clinical Research on Asian Diseases. New Drug Research for Tomorrow – in Asia and Worldside, 2^nd International Conference on Phase I and Early Phase Clinical Trials, hong Kong, 20-21^stNovember, 2015. 2015.

Yuen R.M.F., Early Clinical Research on Asian Diseases, New Drug Research for Tomorrow – in Asia and Worldside, 2nd International Conference on Phase I and Early Phase Clinical Trials, Hong Kong, 20-21 November. 2015.

Yuen R.M.F., Editor, Hepatology International. 2015.

Yuen R.M.F., Editor, Journal of Clinical and Translational Hepatology. 2015.

Yuen R.M.F., Editorial Board Member, Gut and Liver. 2015.

Yuen R.M.F., Editorial Board Member, World Journal of Hepatology. Elsevier, 2015.

Yuen R.M.F., Chan H.L.Y., Liu S.H.K., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lai J.Y.N., Ferrari C. and Gish R.G., Effective inhibition of cccDNA derived mRNA/viral antigens and tolerability with ARC-520. Oral Presentation O-103, The 25^th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. Hepatology International. 2016, 10 (Suppl 1): S44.

Yuen R.M.F., Epidemiology and risk factors: Current situation of HCC in Asian Pacific, 25^th Conference of the Asian Pacific Association for the Study of the Liver, Tokyo, Japan, 20-24 February. 2016.

Yuen R.M.F., HBV replication in HCC patients, Sanofi-Union Hospital HBV Symposium 12th September 2015, Wuhan China. 2015.

Yuen R.M.F., NVR 3-778, a first-in-class HBV core inhibitor, alone and in combination with peg-interferon (PegIFN), in treatment naïve HBeAg-positive patients: early reductions in HBV DNA and HBeAg, Oral presentation at the International Liver Congress, Barcelona, Spain, 13–17 April. 2016.

Yuen R.M.F., Kim D.J., Weilert F., Chan H.L.Y., Lalezari J.P., Hwang S.G., Nguyen T., Liaw S., Brown N., Klumpp K., Flores O., Hartman G. and Gane E., NVR 3-778, a first-in-class HBVCORE inhibitor, alone and incombination with peg-interferon (PEGIFN), in treatment naive HBeAg-positive patients: early reductions in HBV. Late breakers Oral presentation LBO6 DNA and HBeAg, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016. 64(Supp 2): S210-1.

Yuen R.M.F., Need to improve awareness and management of hepatitis B reactivation in patients receiving immunosuppressive therapy, Hepatology International. 2016, 10(1): 102-105.

Yuen R.M.F., RNAi therapeutics for chronic HBV – clinical data, 5^th Asian Conference on Hepatitis & AIDS. From Basic Science to Clinical Practice, Nanjing, China, 28–29 May. 2016.

Yuen R.M.F., Revisit quantitative HBsAg and cccDNA, The Liver Week 2015, Busan Korea, 10-12 September 2015. 2015.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Zeuzem S., Flisiak R., Vierling J.M., Mazur W., Mazzella G., Thongsawat S., Abdurakhmanov D., Van Kính N., Calistru P., Heo J., Stanciu C., Gould M., Makara M., Hsu S.J., Buggisch P., Samuel D., Mutimer D., Nault B., Merz M., Bao W., Griffel L.H., Brass C., Naoumov N.V., Yuen R.M.F. and ESSENTIAL II Study Group , Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (ESSENTIAL II), Alimentary Pharmacology & Therapeutics. 2015, 42(7): 829-844.

Zhu R.X., Seto W.K.W., Lai C.L. and Yuen R.M.F., Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region, Gut and Liver. 2016, 10(3): 332-9.

Researcher : Yung SSY

Project Title:	The Role of Fibronectin in Peritoneal Inflammation and Fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	The role of hyaluronan in peritoneal inflammation and fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Fibronectin fragments and isoforms in the pathogenesis of tubulo-interstitial damage in lupus nephritis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Changes in miR-200a and miR-200b expression in mesothelial cells with time on peritoneal dialysis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	The Role of miR-200c in Peritoneal Inflammation and Fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Persistent peritoneal inflammation and its effect on peritoneal fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

List of Research Outputs

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Liao J., Liu Y., Wu H., Zhao M., Tan Y., Li D., Long H., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q.J., The role of icaritin in regulating Foxp3/IL17a balance in systemic lupus erythematosus and its effects on the treatment of MRL/lpr mice, Clinical Immunology. 2016, 162: 74-83.

Tang Q., Yang Y., Zhao M., Liang G., Wu H., Liu Q., Xie Y., Li D., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., Mycophenolic acid upregulates miR-142-3P/5P and miR-146a in lupus CD4+T cells, Lupus. 2015, 24: 935-942.

Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang C. and Chan D.T.M., Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis, Lupus. 2016, 25(1): 46-53.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yung S.S.Y. and Chan D.T.M., Mechanisms of Kidney Injury in Lupus Nephritis - the Role of Anti-dsDNA Antibodies, Frontiers in Immunology. 2015, 6.

Yung S.S.Y. and Chan D.T.M., Molecular and Immunological Basis of Tubulo-Interstitial Injury in Lupus Nephritis: a Comprehensive Review, Clinical Reviews in Allergy & Immunology. 2016.

Yung S.S.Y., LI N., Chau K.M., Kam K.M. and Chan D.T.M., Peritonitis induces native and EDA+ fibronectin synthesis in human peritoneal mesothelial cells through PI3K and MAPK activation, ASN Kidney Week 2015.

Researcher : ZHANG A

List of Research Outputs

Wong D.K.H., ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Deep sequencing analysis of hepatitis B virus quasispecies characteristics in the pre-S region prior to development of hepatocellular carcinoma. Poster presentation THU-111, The International Liver Congress™ 2016 – 51^st Annual meeting of the European Association for the Study of the Liver, 13-17 April, 2016, Barcelona, Spain.. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2016, 64(Suppl 2): S357.

ZHANG A., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma, PLOS ONE. 2015, 10(9): e0139478.

ZHANG A., Lai C.L., Poon R.T.P., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma, Journal of Gastroenterology and Hepatology. 2016.

Researcher : ZHANG R

List of Research Outputs

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Researcher : ZHEN Z

List of Research Outputs

CHEN Y., Seto W.K.W., ZHEN Z., Liu J., Yuen M.F., Lau C.P., Tse H.F. and Yiu K.H., A Detailed Evaluation of the Relationship between Tricuspid Regurgitation and Liver Stiffness Measured by Transient Elastography, 20th Research Postgraduate Symposium. 2015.

CHEN Y., Chan A.C.Y., Chan S.C., Chok K.S.H., Sharr W.W., Fung J.Y.Y., Liu J., ZHEN Z., Sin W.C., Lo C.M., Tse H.F. and Yiu K.H., A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, Journal of Cardiology. 2015, 67(2): 140-146.

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

CHEN Y., Seto W.K.W., Ho L.M., Fung J.Y.Y., Jim M.H., Yip W.K.G., Fan K.Y.Y., ZHEN Z., Liu J., Yuen R.M.F., Lau C.P., Tse H.F. and Yiu K.H., Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. 2016, 117(4): 640-646.

Liu J., CHEN Y., Yuen M.A.M., ZHEN Z., Chan W.S., Lam K.S.L., Tse H.F. and Yiu K.H., Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2016, 15: 22.

WANG Y., Liu H.H.L., Zhen Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Periodontitis links with EPC counts in patients with T2 diabetes, Journal of Dental Research. 2016, 95 (Spec Iss B): 587.

ZHEN Z., CHEN Y., Shih K.C., Liu J., Yuen M.A.M., Wong D.S.H., Lam K.S.L., Tse H.F. and Yiu K.H., Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study, Cardiovascular Diabetology. 2015, 14: 123.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

ZHEN Z., CHEN Y., Liu J., Chan W.S., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Increased T-wave alternans is associated with subclinical myocardial structural and functional abnormalities in patients with type 2 diabetes, Journal of Cardiology. 2015.

Researcher : Zhang J

List of Research Outputs

Hui X., Gu P., Zhang J., Nie T., PAN Y., Wu D., FENG T., Zhong C., Wang Y., Lam K.S.L. and Xu A., Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation, Cell Metabolism. 2015.

Researcher : Zhang Q

List of Research Outputs

Chan D.T.M., Chan P.L., Yap Y.H.D., Zhang Q., Chau K.M. and Yung S.S.Y., Serum acetate and lipopolysaccharide levels correlate with disease activity in patients with lupus nephritis, ASN Kidney Week 2015.

Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang C. and Chan D.T.M., Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis, Lupus. 2016, 25(1): 46-53.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Zhang Y

Project Title:	Important roles of Rap1/NF-κB signal pathway in regulation of mesenchymal stem cells (MSCs)-secreted cytokines and survival in myocardial infarction
Investigator(s):	Zhang Y, Lian Q
Department:	Ophthalmology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015

Project Title:	ESC Congress 2015; Inhibition of Rap1 enhances mesenchymal stem cells-mediated heart protection following myocardial infarction
Investigator(s):	Zhang Y
Department:	Ophthalmology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	09/2015

List of Research Outputs

Han Q., Li G., Mak J.C.W., Zhang Y., Ip M.S.M. and Zhang N., The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo, Zhonghua Jie He He Hu Xi Za Zhi. 2015, 38: 516-519.

LI X., Michaeloudes C., Zhang Y., Lian Q., Bhavsar P.K., Ip M.S.M., Chung K.F. and Mak J.C.W., Poster Presentation Award at the 20th Research Postgraduate Symposium, The University of Hong Kong, Faculty of Medicine. 2015.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Paracrine effect of human mesenchymal stem cell on cigarette smoke medium-exposed human AC16 cardiomyocytes, 21st Medical Research Conference, The University of Hong Kong, Hong Kong Medical Journal. 2016, 22 (Suppl.1): 40.

Researcher : Zhen Z

List of Research Outputs

CHEN Y., ZHEN Z., Liu J., Tse H.F. and Yiu K.H., Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation, ESC CONGRESS 2015.

ZHEN Z., CHEN Y., Liu J., Lai I.A., Jin L., Tse H.F. and Yiu K.H., Association of periodontitis with asymptomatic cardiac dysfunction in patients with diabetes, European Society Congress 2015.

Researcher : Zhou Y

List of Research Outputs

Li X., Cheng K.Y., LIU Z., Yang J., WANG B., Jiang X., Zhou Y., Hallenborg P., Hoo R.L.C., Lam K.S.L., Ikeda Y., Gao X. and Xu A., The MDM2-p53-pyruvate carboxylase axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β cells., Nature Communications. Nature, 2016.

Researcher : Zhu CF

Project Title:	Deciphering the role of adipose tissue inflammation and adipokines in gut microbiota-induced systemic insulin resistance and metabolic dysregulation
Investigator(s):	Zhu CF, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

List of Research Outputs

Zhu C.F., 《The mechanism of marine collagen peptide reduced early injure of endothelial cells in diabetes mellitus rat》, 2016年第四届国际食源肽学术研讨会, 2016, 1.

Researcher : Zhu H

List of Research Outputs

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

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