DEPT OF CLINICAL ONCOLOGY
Researcher : Au GKH |
List of Research Outputs |
Chua D.T.T., Sham J.S.T. and Au G.K.H., A phase II study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma. , Oral Oncology. 2005, 41(6): 589-595. |
Chua D.T.T., Sham J.S.T. and Au G.K.H., Induction chemotherapy with cisplatin and gemcitabine followed by reirradiation for locally recurrent nasopharyngeal carcinoma, American Journal of Clinical Oncology. 2005, 28: 464-471. |
Chua D.T.T., Sham J.S.T., Leung L.H.T. and Au G.K.H., Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy. , Radiotherapy & Oncology. 2005, 77(3): 290-294. |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Au SK |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Chen M |
List of Research Outputs |
Tai L.S., Mak W.W., Ng P.K.M., Chua D.T.T., Fu L., Chu K.W., Song Y. and Chen M., High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers, In: Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan X , Cancer Research. 2006, 66(8): 4133-4138. |
Researcher : Chu KW |
List of Research Outputs |
Tai L.S., Mak W.W., Ng P.K.M., Chua D.T.T., Fu L., Chu K.W., Song Y. and Chen M., High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers, In: Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan X , Cancer Research. 2006, 66(8): 4133-4138. |
Researcher : Chua DTT |
List of Research Outputs |
Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Sarraf M., Chi K.H., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J.P., Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. , International Journal of Radiation Oncology Biology Physcis. 2006, 64(1): 47-56. |
Chua D.T.T., Sham J.S.T. and Au G.K.H., A phase II study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma. , Oral Oncology. 2005, 41(6): 589-595. |
Chua D.T.T., Sham J.S.T. and Au G.K.H., Induction chemotherapy with cisplatin and gemcitabine followed by reirradiation for locally recurrent nasopharyngeal carcinoma, American Journal of Clinical Oncology. 2005, 28: 464-471. |
Chua D.T.T., Sham J.S.T., Leung L.H.T. and Au G.K.H., Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy. , Radiotherapy & Oncology. 2005, 77(3): 290-294. |
Ho J.C.M., Chua D.T.T., Cheng A.C., Sham J.S.T., Lam W.K. and Wong M.P., Predictive role of mutational status of epidermal growth factor receptor in clinical response to gefitinib in advanced non-small cell lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2006, Abstract Book: pp. 58. |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Lin S.S., Chua D.T.T., Lee C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression., In: Belinda S.S. Lin, Daniel T.T. Chua, Davy C.W. Lee, Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005. |
Su C., Peng L., Sham J.S.T., Wang X., Zhang Q., Chua D.T.T., Liu C., Cui Z., Xue H., Wu H., Yang Q., Zhang B., Liu X., Wu M. and Qian Q., Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice. , Molecular Therapy. 2006, 13(5): 918-927. |
Tai L.S., Mak W.W., Ng P.K.M., Chua D.T.T., Fu L., Chu K.W., Song Y. and Chen M., High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers, In: Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan X , Cancer Research. 2006, 66(8): 4133-4138. |
Tian Y., Chua D.T.T. and Sham J.S.T., Concomitant chemo-radiotherapy for locoregionally advanced nasopharygeal carcinoma, Zhonghua Zhong Liu Za Zhi. 2005, 27(7): 429-431. |
Wong M.P., Chua D.T.T., Ho J.C.M., Tam I.Y.S., Lam W.K. and Chung L.P., Mutational status of epidermal growth factor receptor is the only predictor of clinical response to gefitinib treatment in non-small cell lung cancer, 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006 . 2006. |
Zheng Y., Cao K., Ng S.P., Chua D.T.T., Sham J.S.T., Kwong D.L.W., Ng M.H., Lu L. and Zheng B., Complementary activation of peripheral natural killer cell immunity in nasopharyngeal carcinoma, Cancer Science. 2006, 97(9): 912-9. |
Researcher : Fu L |
List of Research Outputs |
Tai L.S., Mak W.W., Ng P.K.M., Chua D.T.T., Fu L., Chu K.W., Song Y. and Chen M., High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers, In: Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan X , Cancer Research. 2006, 66(8): 4133-4138. |
Researcher : Guan XY |
Project Title: | Isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
Start Date: | 05/2001 |
Abstract: |
To study isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis. |
Project Title: | Basic research for the mechanisms of development and progression of malignant tumors |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
Start Date: | 03/2002 |
Abstract: |
To identify recurrent genomic alterations in 30 primary adenocarcinomas of lung and carcinomas using CGH technology; to establish gene expression profiles for lung cancer using cDNA microarray technique; to establish 10 pairs of xenografts of primary and their matched metastatic lung cancer by transplanting tumor cells into nude mice; to study the differences between primary and metastasis lung cancer with mentioned xenografts. |
Project Title: | Characterization of roles of a new candidate oncogene eIF-5A2 in cancer development |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
Start Date: | 10/2002 |
Completion Date: | 09/2005 |
Abstract: |
The project is proposed to understand the tumorigenicity of the eIF-5A2 gene by in vitro assays (soft-agar assay and focus-formation assay) and in vivo approach (tumour formation in nude mouse). A broad survey using high-throughput tissue microarray will be employed to investigate the association of eIF-5A2 amplification and clinical features of various cancers by fluorescence in situ hybridization (FISH). |
Project Title: | Identification of the mechanism of hepatitis B virus (HBV) integration in the development of hepatocellular carcinoma (HCC) |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Seed Funding Programme for Basic Research |
Start Date: | 01/2003 |
Abstract: |
Although the integration of HBV has been associated with the development of HCC, the molecular mehanism remains unclear. It is believed that HBV and host factors (e.g. inflammatory/genetic factors) may contribute together to the process of HCC development. Although the association of HBV and HCC development has been widely studied, only a limited number of integrated HBV have been completely analyzed. Therefore, additional studies with more cases are needed to understand roles of HBV integrants involved in the HCC development. In order to obtain additional insight into the correlation of HBV integration and HCC development, integrated HBV in 10-20 HCC cases will be isolated and characterized by sequencing analysis. findings in this project may greatly facilitate the early diagnosis and prevention of HCC. |
Project Title: | Characterization of oncogenic role of SEI-1 in the development of ovarian cancer |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Seed Funding Programme for Basic Research |
Start Date: | 02/2004 |
Abstract: |
To study the tumorigenisity of SEI-1 using both in vitro and in vivo approaches; to define the clinical and pathological significance of the amplification of SEI-1 in ovarian cancer. |
Project Title: | Characterization of roles of a novel oncogene ALC-1 in the development of hepatocellular carcinoma |
Investigator(s): | Guan XY, Huang J |
Department: | Clinical Oncology |
Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
Start Date: | 10/2004 |
Abstract: |
To confirm the tumorigenic role of ALC-1; to investigate the biochemical properties of ALC-1; to study the functions of ALC-1 in vivo by the generation and characterization of transgenic mice overexpressing the ALC-1 gene; to define the clinical and pathological significance of the amplification of ALC-1 in HCC using high-throughput tissue microarray. |
Project Title: | Oncogeneic role of hepatitis B Virus (HBV) X gene in the development of hepatocellular carcinoma |
Investigator(s): | Guan XY, Sham JST |
Department: | Clinical Oncology |
Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: | 01/2005 |
Abstract: |
To investigate three aspect: 1) characterization of biological role of full-length X and truncated HBx in cell proliferation and apoptosis; 2) identification and characterization of genes regulated by full-length X and truncated HBx using cDNA microarray; 3) construction of an HCC tissue microarray (TMA) with HBV-positive and HBV-negative HCC cases, and application of the TMA in the characterization of candidate genes correlated with HCC carcinogenesis. |
Project Title: | Characterization of roles of a novel oncogene ALC-1 in the development of hepatocellular carcinoma |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
Start Date: | 01/2005 |
Abstract: |
N/A |
Project Title: | Characterization of
tumor suppressing role of tyrosine aminotransferase
gene ( |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
Start Date: | 07/2005 |
Completion Date: | 06/2006 |
Abstract: |
N/A |
Project Title: | Characterization of Tumor Suppressing Role of Tyrosine Aminotransferase in HCC |
Investigator(s): | Guan XY |
Department: | Clinical Oncology |
Source(s) of Funding: | Small Project Funding |
Start Date: | 09/2005 |
Abstract: |
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, especially in Asia including China, and its prognosis has been very poor. It is believed that the pathogenesis of HCC is a long-term process that involves multiple genetic alterations. Deletion of 16q is one of the most frequent chromosomal alterations in primary HCC, as observed in studies using loss of heterozygosity (LOH) and comparative genomic hybridization (CGH). In our previous CGH study, the loss of 16q was observed at a strikingly high rate of 70% in 50 primary HCC cases and this deletion may be an early event in the pathogenesis of HCC. These results strongly suggest that 16q may harbor one or more tumor suppressor genes. Recently, a candidate tumor suppressor gene, Tyrosine aminotransferase (TAT), at 16q22.1 was isolated by cDNA subtraction. Our preliminary work showed that absence and marked reduction expression of TAT was frequently observed in HCC. In addition, homo-deletion of TAT gene was detected in 2/24 HCC cases. TAT encodes the enzyme tyrosine aminotransferase which controls the rate-limiting step for tyrosine catabolism. Many studies have demonstrated that defects in tyrosine catabolism are associated with liver cirrhosis and HCC development. These results suggest that TAT is a candidate tumor suppressor gene and may play an important role in the pathogenesis of HCC. The key objective of this proposal is to investigate the tumor suppressing function of TAT and its role in HCC development. Objectives 1) To investigation of the loss of DNA copy-number in TAT region at 16q22.1 in primary HCC cases. Deletion of DNA copy-number will be studied by real-time PCR. 2) To study TAT expression level in primary HCC cases. TAT expression level in primary HCCs will be compared with their matched non-tumor liver tissues by Northern blot analysis. 3) Mutation analysis of TAT gene and characterization of methylation status at promoter region of TAT gene. |
List of Research Outputs |
Cheung A., Deng W., Tsao G.S.W. and Guan X.Y., Chromosome/DNA: aneuploidy and centromeres/kinetochores, and cohesion/chromosome condensation, The FASEB Journal. 2006, 20 No. 5: A894 No.587.1. |
Cheung H.W., Chun C.S., Wang Q., Deng W., Hu L., Guan X.Y., Nicholls J.M., Ling M.T., Wong Y.C., Tsao G.S.W., Jin D. and Wang X., Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents, Cancer Research. 2006, 66(8): 4357-4367. |
Guan X.Y., Lau B.S.H. and Wang Y., Role of Hepatitis B Surface Antigen in Hepatocarcinogenesis, In: Hayat MA, Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas. Elsevier Inc., 2005, 3: 229-236. |
Hui A.B., Or Y.Y., Takano H., Tsang R.K., To K.F., Guan X.Y., Sham J.S.T., Hung K.W., Lam C.N., van Hasselt C.A., Kuo W.L., Gray J.W., Huang D.P. and Lo K.W., Array-based comparative genomic hybridization analysis identified Cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma., Cancer Research. 2005, 65: 8125-8133. |
Lee K.W., Poon R.T.P., Man K., Guan X.Y. and Fan S.T., Identification of biomarkers for metastatic hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006. |
Liu B., Wang J., Chan K.M.J., Tjia W.M., Deng W., Guan X.Y., Huang J., Li S.K.M., Chau P.Y.P., Chen D., Pei D., Pendas A., Cadiñanos J., López-Otín C., Tse H.F., Hutchison C., Chen J., Cao Y., Cheah K.S.E., Tryggvason K. and Zhou Z., Genomic Instability In Laminopathy-based Premature Aging, Nature Medicine. 2005, 11 (7): 780-785. |
Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006. |
Qiao G.B., Wu Y.L., Yang X.N., Zhong W.Z., Xie D., Guan X.Y., Fischer D., Kolberg H.C., Kruger S. and Stuerzbecher H.W., High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients, British Journal of Cancer. 2005, 93(1): 137-143. |
Tai L.S., Sham J.S.T., Xie D., Fang Y., Wu Y.L., Hu L., Deng W., Tsao G.S.W., Qiao G.B., Cheung A. and Guan X.Y., Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma, Cancer. 2006, 106: 146-155. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Sham J.S.T., Zeng W.F., Lin H.L., Bi J., Che L.H., Hu L. and Guan X.Y., Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma, Human Pathology. 2005, 36(7): 777-783. |
Xie D., Zeng Y.X., Wang H.J., Wen J.M., Tao Y., Sham J.S.T. and Guan X.Y., Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma., British Journal of Cancer. 2006, 94: 108-114. |
Researcher : Hu L |
List of Research Outputs |
Cheung H.W., Chun C.S., Wang Q., Deng W., Hu L., Guan X.Y., Nicholls J.M., Ling M.T., Wong Y.C., Tsao G.S.W., Jin D. and Wang X., Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents, Cancer Research. 2006, 66(8): 4357-4367. |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Tai L.S., Sham J.S.T., Xie D., Fang Y., Wu Y.L., Hu L., Deng W., Tsao G.S.W., Qiao G.B., Cheung A. and Guan X.Y., Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma, Cancer. 2006, 106: 146-155. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Sham J.S.T., Zeng W.F., Lin H.L., Bi J., Che L.H., Hu L. and Guan X.Y., Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma, Human Pathology. 2005, 36(7): 777-783. |
Researcher : Hu L |
List of Research Outputs |
Cheung H.W., Chun C.S., Wang Q., Deng W., Hu L., Guan X.Y., Nicholls J.M., Ling M.T., Wong Y.C., Tsao G.S.W., Jin D. and Wang X., Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents, Cancer Research. 2006, 66(8): 4357-4367. |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Tai L.S., Sham J.S.T., Xie D., Fang Y., Wu Y.L., Hu L., Deng W., Tsao G.S.W., Qiao G.B., Cheung A. and Guan X.Y., Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma, Cancer. 2006, 106: 146-155. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Sham J.S.T., Zeng W.F., Lin H.L., Bi J., Che L.H., Hu L. and Guan X.Y., Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma, Human Pathology. 2005, 36(7): 777-783. |
Researcher : Kwong DLW |
Project Title: | A pilot study for radiosensitization with COX-2 inhibitor for nasopharyngeal carcinoma |
Investigator(s): | Kwong DLW, Nicholls JM |
Department: | Clinical Oncology |
Source(s) of Funding: | Small Project Funding |
Start Date: | 12/2005 |
Completion Date: | 11/2006 |
Abstract: |
1. To assess feasibility and toxicity of COX-2 inhibition in addition to radiotherapy/chemoradiation for nasopharyngeal carcinoma. 2. To assess molecular response in tumor to COX-2 inhibition by biopsies taken during treatment. Markers for COX-2, angiogenesis and proliferation will be studied by immunochemistry and RNA microarray. |
List of Research Outputs |
Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Sarraf M., Chi K.H., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J.P., Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. , International Journal of Radiation Oncology Biology Physcis. 2006, 64(1): 47-56. |
Khong P.L., Leung L.H.T., Fung A.S.M., Fong D.Y.T., Qiu D., Kwong D.L.W., Ooi C.G.C., McAlonan G.M., Cao G. and Chan G.C.F., White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function, Journal of Clinical Oncology. 2006, 24(6): 884-890. |
Kwong D.L.W., Advance in radiotherapy for nasopharyngeal carcinoma, Frontiers in Biomedical Research, HKU. 2005. |
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Neoadjuvant chemoradiation changes the relationship between pT and pN status, and their prognostic significance in esophageal cancer (Abstract), Forty-Seventh Annual Meeting of The Society for Surgery of the Alimentary Tract (DDW), Los Angeles, 20-24 May. 2006. |
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., The effects of neoadjuvant chemoradiation on the relationship between PT and PN status, and their prognostic significance in esophageal cancer (Poster Abstract), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006. |
Li J., Kwong D.L.W. and Chan G.C.F., Short term and prolonged effects of irradiation on human mesenchymal stem cells, Biology of Blood and Marrow Transplantation (Abstracts from the 2006 BMT Tandem Meetings), Honolulu, Hawaii, February 2006. 12(2): 108. |
Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Discrepant FA reduction between the frontal and parietal lobes of post irradiation medulloblastoma survivors: preliminary findings of regional susceptibility?, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
Qiu D., Leung L.H.T., Kwong D.L.W., Chan G.C.F. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, NeuroImage. 2006, 31: 109-115. |
Zheng Y., Cao K., Ng S.P., Chua D.T.T., Sham J.S.T., Kwong D.L.W., Ng M.H., Lu L. and Zheng B., Complementary activation of peripheral natural killer cell immunity in nasopharyngeal carcinoma, Cancer Science. 2006, 97(9): 912-9. |
Researcher : Lau BSH |
List of Research Outputs |
Guan X.Y., Lau B.S.H. and Wang Y., Role of Hepatitis B Surface Antigen in Hepatocarcinogenesis, In: Hayat MA, Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas. Elsevier Inc., 2005, 3: 229-236. |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Researcher : Lau WH |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Law CK |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Lee AWM |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Leung TW |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Liu KY |
List of Research Outputs |
Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006. |
Researcher : Ma N |
List of Research Outputs |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Researcher : Ngan KC |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Qian Q |
List of Research Outputs |
Su C., Peng L., Sham J.S.T., Wang X., Zhang Q., Chua D.T.T., Liu C., Cui Z., Xue H., Wu H., Yang Q., Zhang B., Liu X., Wu M. and Qian Q., Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice. , Molecular Therapy. 2006, 13(5): 918-927. |
Researcher : Sham JST |
List of Research Outputs |
Chan C.H.Y., Ho T.H., Chan C.L.W., Sham J.S.T. and Chow L.W.C., Regaining Coherence: Towards an Outcome Measurement for Meaning-making Intervention with Chinese Cancer Patients, 12th Hong Kong International Cancer Congress, Hong Kong. 2005. |
Chua D.T.T., Sham J.S.T. and Au G.K.H., A phase II study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma. , Oral Oncology. 2005, 41(6): 589-595. |
Chua D.T.T., Sham J.S.T. and Au G.K.H., Induction chemotherapy with cisplatin and gemcitabine followed by reirradiation for locally recurrent nasopharyngeal carcinoma, American Journal of Clinical Oncology. 2005, 28: 464-471. |
Chua D.T.T., Sham J.S.T., Leung L.H.T. and Au G.K.H., Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy. , Radiotherapy & Oncology. 2005, 77(3): 290-294. |
Ho J.C.M., Chua D.T.T., Cheng A.C., Sham J.S.T., Lam W.K. and Wong M.P., Predictive role of mutational status of epidermal growth factor receptor in clinical response to gefitinib in advanced non-small cell lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2006, Abstract Book: pp. 58. |
Hui A.B., Or Y.Y., Takano H., Tsang R.K., To K.F., Guan X.Y., Sham J.S.T., Hung K.W., Lam C.N., van Hasselt C.A., Kuo W.L., Gray J.W., Huang D.P. and Lo K.W., Array-based comparative genomic hybridization analysis identified Cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma., Cancer Research. 2005, 65: 8125-8133. |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Neoadjuvant chemoradiation changes the relationship between pT and pN status, and their prognostic significance in esophageal cancer (Abstract), Forty-Seventh Annual Meeting of The Society for Surgery of the Alimentary Tract (DDW), Los Angeles, 20-24 May. 2006. |
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., The effects of neoadjuvant chemoradiation on the relationship between PT and PN status, and their prognostic significance in esophageal cancer (Poster Abstract), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006. |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Lo P.H.Y., Ho T.H., Chan C.L.W., Lee P.W.H., Chow L.W.C., Ho M.Y. and Sham J.S.T., Differences in coping styles of breast cancer patients undergoing total or partial mastectomy, 12th Hong Kong International Cancer Congress, Hong Kong. 2005. |
Su C., Peng L., Sham J.S.T., Wang X., Zhang Q., Chua D.T.T., Liu C., Cui Z., Xue H., Wu H., Yang Q., Zhang B., Liu X., Wu M. and Qian Q., Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice. , Molecular Therapy. 2006, 13(5): 918-927. |
Tai L.S., Sham J.S.T., Xie D., Fang Y., Wu Y.L., Hu L., Deng W., Tsao G.S.W., Qiao G.B., Cheung A. and Guan X.Y., Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma, Cancer. 2006, 106: 146-155. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Tian Y., Chua D.T.T. and Sham J.S.T., Concomitant chemo-radiotherapy for locoregionally advanced nasopharygeal carcinoma, Zhonghua Zhong Liu Za Zhi. 2005, 27(7): 429-431. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Sham J.S.T., Zeng W.F., Lin H.L., Bi J., Che L.H., Hu L. and Guan X.Y., Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma, Human Pathology. 2005, 36(7): 777-783. |
Xie D., Zeng Y.X., Wang H.J., Wen J.M., Tao Y., Sham J.S.T. and Guan X.Y., Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma., British Journal of Cancer. 2006, 94: 108-114. |
Zheng Y., Cao K., Ng S.P., Chua D.T.T., Sham J.S.T., Kwong D.L.W., Ng M.H., Lu L. and Zheng B., Complementary activation of peripheral natural killer cell immunity in nasopharyngeal carcinoma, Cancer Science. 2006, 97(9): 912-9. |
Researcher : Sze WM |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |
Researcher : Tai LS |
List of Research Outputs |
Tai L.S., Sham J.S.T., Xie D., Fang Y., Wu Y.L., Hu L., Deng W., Tsao G.S.W., Qiao G.B., Cheung A. and Guan X.Y., Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma, Cancer. 2006, 106: 146-155. |
Tai L.S., Mak W.W., Ng P.K.M., Chua D.T.T., Fu L., Chu K.W., Song Y. and Chen M., High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers, In: Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan X , Cancer Research. 2006, 66(8): 4133-4138. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Researcher : Tang D |
List of Research Outputs |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Researcher : Tang D |
List of Research Outputs |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Tang D., Hu L., Xie D., Wu Q.L., Fang Y., Zeng Y., Sham J.S.T. and Guan X.Y., Oncogenic transformation by SEI-1 is associated with chromosomal instability, Cancer Research. 2005, 65(15): 6504-6508. |
Researcher : Tjia WM |
List of Research Outputs |
Liu B., Wang J., Chan K.M.J., Tjia W.M., Deng W., Guan X.Y., Huang J., Li S.K.M., Chau P.Y.P., Chen D., Pei D., Pendas A., Cadiñanos J., López-Otín C., Tse H.F., Hutchison C., Chen J., Cao Y., Cheah K.S.E., Tryggvason K. and Zhou Z., Genomic Instability In Laminopathy-based Premature Aging, Nature Medicine. 2005, 11 (7): 780-785. |
Researcher : Xie D |
List of Research Outputs |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Qiao G.B., Wu Y.L., Yang X.N., Zhong W.Z., Xie D., Guan X.Y., Fischer D., Kolberg H.C., Kruger S. and Stuerzbecher H.W., High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients, British Journal of Cancer. 2005, 93(1): 137-143. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Zeng Y.X., Wang H.J., Wen J.M., Tao Y., Sham J.S.T. and Guan X.Y., Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma., British Journal of Cancer. 2006, 94: 108-114. |
Researcher : Xie D |
List of Research Outputs |
Lau B.S.H., Sham J.S.T., Xie D., Tzang C.H., Tang D., Ma N., Hu L., Wen J.M. and Xiao G., Clusterin plays an important role in hepatocellular carcinoma metastasis., Oncogene. 2006, 25: 1242-1250. |
Qiao G.B., Wu Y.L., Yang X.N., Zhong W.Z., Xie D., Guan X.Y., Fischer D., Kolberg H.C., Kruger S. and Stuerzbecher H.W., High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients, British Journal of Cancer. 2005, 93(1): 137-143. |
Xie D., Tai L.S., Ma N., Hu L., Sham J.S.T. and Guan X.Y., Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway, In: Xie D, Zeng YX, Wang HJ, Tai LS, Wen JM, Tao Y, Ma NF, Hu L, Sham JS, Guan XY, Acta Neuropathol (Berl). 2005, 110(5): 481-489. |
Xie D., Zeng Y.X., Wang H.J., Wen J.M., Tao Y., Sham J.S.T. and Guan X.Y., Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma., British Journal of Cancer. 2006, 94: 108-114. |
Researcher : Yau TK |
List of Research Outputs |
Lee A.W.M., Lau W.H., Tung S.Y., Chua D.T.T., Chappell R., Xu L., Siu L., Sze W.M., Leung T.W., Sham J.S.T., Ngan K.C., Law C.K., Yau T.K., Au S.K., O'Sullivan B., Pang E.S., O S.K., Au G.K.H. and Lau J.T., Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group., Journal of Clinical Oncology. 2005, 23(28): 6966-6975. |