Dept of Paediatrics & Adolescent Med

DEPT OF PAEDIATRICS & ADOLESCENT MED

Researcher : Bhatia I

List of Research Outputs

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis for putative transcription factor binding sites of a novel hypoxic-ischaemic regulated gene - HID-1, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 61.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis of putative promoter sequences of known and novel genes identified by hpoxic-ischaemic insult, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 118.

Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54.

Researcher : Chan CH

List of Research Outputs

Lee R.H.K., Wong W.L., Chan C.H. and Chan S.Y., Differential Effects of Glial Cell Line-Derived Neurotrophic Factor and Neurturin in RET / GFRa1-Expressing Cells, Journal of Neuroscience Research. Wiley InterScience, 2006, 83: 80-90.

Researcher : Chan GCF

Project Title:	Review of local experience in the management of childhood myelodysplastic syndrome
Investigator(s):	Chan GCF,
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/2001

Abstract:

To study the local incidence and outcome of this rare type of childhood maliquancy.

Project Title:	Treatment protocol for childhood medulloblastoma in Hong Kong
Investigator(s):	Chan GCF,
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/2001

Abstract:

To study the treatment outcome of this most common form of childhood brain tumour in Hong Kong.

Project Title:	Survey on the prevalence on use of alternative medical treatment in paediatric patients
Investigator(s):	Chan GCF
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	09/2001

Abstract:

To study the prevalence, pattern of usage and the underlying predisposing factors on the use of alternative medicine in children.

Project Title:	Direct generation and functional characterization of human dendritic cells derived from bone marrow cells of leukemic origins
Investigator(s):	Chan GCF, Chiu CSW, Ma ESK, Huang F
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/2002

Abstract:

To determine the implication of dentritic cells generated from leukaemic cellls on the host immune system.

Project Title:	Exploring the chemo-resistant mechanisms of human mesenchymal stem cells: the roles of genetic and epigenetic events involved in the apoptosis pathway
Investigator(s):	Chan GCF
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To examine the chemo-resistant mechanisms involved including: a) the methylation status of the apoptotic genes in the extrinsic apoptotic pathway (eg. caspases) and the expression level of anti-apoptotic molecules in the intrinsic apoptotic pathway (eg. BC1-2 family) and anti-oxidative species (eg. glutathione).

Project Title:	Health-related quality of life measures for Hong Kong Chinese children with cancer
Investigator(s):	Chan GCF, Fielding R, Lam WWT, Ng MW
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	01/2005

Abstract:

Children under age 5 constiture >50% of new paediatric cancer cases. HRQoL impacts on these children are currently arbitrarily assessed (in HK) or use proxy measures which lack reliability and are subject to significant bias. A tool measuring changes in HRQoL would be of great value to paediatric oncologists to better and more consistently address HRQoL impacts, facilitating optimized paediatric cancer care. Such a tool is currently lacking and is badly needed

Project Title:	Influence of MYCN amplification on the response of neuroblastoma to arsenic trioxide (As₂O₃) in-vitro and in-vivo
Investigator(s):	Chan GCF
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2005

Abstract:

N/A

Project Title:	Influence of MYCN amplification on the response of neuroblastoma to arsenic trioxide (As₂O₃) in-vitro and in-vivo
Investigator(s):	Chan GCF, Schwab M, Thomas W
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2005

Abstract:

To find out whether As₂O₃ can induce apoption on both MYCN amplified and non-amplified neuroblastoma cells; to identify the in reinstance pattern to As₂O₃ and replace whether resistant clones may generate faster from neuroblastoma cells with MYCN amplification; to established a dose limiting toxicity profile of As₂O₃ in vivo and study the toxicity, bio-availability and bio-distribution of arsenical compounds.

Project Title:	Comparing the effect of different purified beta-glucans on the maturation and function of human dendritic cells (DC) in vitro
Investigator(s):	Chan GCF, Chan Wing Keung
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Abstract:

We will investigate and compare the effect of different beta-glucans on human immune cells in particularly on the dendritic cells (DC) in vitro.

List of Research Outputs

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

Chan B.P., Leung M.K.H., Yeung C.W., Li J., Mo I. and Chan G.C.F., A novel 3-dimensiona culture system for human mesenchymal stem cells, International Society for Stem Cell Research 4th Annual Meeting. Toronto, Ontario, Canada, 2006, 98.

Chan C., Chan W.K., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium extract can enhance maturation of human monocyte-derived dendritic cells, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 577.

Chan C., Chan G.C.F., Shing M.M.K., Luk C.W., Lee A.C.W. and Ling S.C., Outcome of using stratified treatment approach based on inss staging in childhood neuroblastoma: The Hong Kong Experience, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 534.

Chan G.C.F., Applying Experimental Treatments to Metastatic Neurobloastoma: the Hong Kong Experience, Japanese Journal 0f Pediatric Oncology. 2005, 42(3): 516.

Chan G.C.F., As Chairperson for Session 20: State-of-the-Art Lecture Bone Marrow Transplantation, 12^th Hong Kong International Cancer Congress, HKU, 8-10 December 2005. 2005.

Chan G.C.F., Mo F.Y., Yip H.K., Li J., Law H.K.W. and Lau Y.L., Bacterial Endotoxin LPS but Not LTA Can Enhance Osteogenic Differentiation of Human Mesenchymal Stell Cells, Blood. 2005, 106(11): 138b.

Chan G.C.F., Effects of Extrinsic Factors on the Growth and Differentiation of Human Mesenchymal Stem Cells, 12^th Hong Kong International Cancer Congress, Faculty of Medicine, HKU, 8-10 December 2005. 16.2.

Chan G.C.F., Global Research Fellowship Award, Advance in Neuroblastoma Research Meeting 2006, Los Angeles, USA. 2006.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Immunopotent Polysaccharides of Different Sources Selectively Activate Human Dendritic Cells, Blood. 2005, 106(11): 49b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Lingzhi polysaccharides can activate human dendritic cells maturation, 2005年全國小兒血液/腫瘤學術會議, Hangzhou, PR China, 9-13 October 2005, Hangzhou, PR China, 2005, 84-85.

Chan G.C.F., Recent Advances in Childhood Brain Tumours, Hong Kong Journal of Paediatrics (new series). 2006, 11: 3-12.

Chan G.C.F., Shing M.M.K., Luk C.W., Lee A.C.W., Ling S.C., Li C.K. and Ha S.Y., Treatment Outcome of Childhood Neuroblastoma: the Hong Kong Experience, 4^th Congress of the International Society of Pediatric Oncology-Asia, Shanghai, PR China, 6-8 April 2006.

Chan G.C.F., Use of "Adult Stem Cells" in Children: the Current Status and Future Potentials, Stem Cells From Bench to Bedside (Abstract book of "The Federation's Annual Scientific Meeting 2006", Hong Kong, 10 June 2006. 15.

Chan G.C.F., 認識兒童癌症, 兒童癌病基金, Hong Kong, Children's Canceer Foundation, 2006, 50-60,97-105,106-112.

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Cheuk D.K.L., Lee T.L., Ha S.Y., Chan G.C.F., Lau Y.L. and Chiang A.K.S., Bone Marrow Transplantation for Hepatitis-associated Aplastic Anaemia: Case Reports and a Review of the Literature, Hong Kong Journal of Paediatrics (new series). 2006, 11: 32-38.

Cheuk D.K.L., Lee A.C.W., Chiang A.K.S., Ho M.H.K., Ha S.Y., Chan G.C.F. and Lau Y.L., Quality of life study on transfusion-dependent thalassemic patients in Hong Kong, 10^th International Conference on Thalassaemia & Haemoglobinopathies & 12^th International TIF Conference for Thalassaemia Patients and Parents, Dubai, United Arab Emirates, 7-10 January 2006. 148.

Chow I.P.S., Fielding R., Lam W.W.T., Byrne J. and Chan G.C.F., Association of colour with emotional state and sensation among Cantonese speaking children aged 3 - 8 years., Annual conference, Hong Kong Paediatrics Society, HKSAR, January 8th, . 2006.

Chow I.P.S., Fielding R., Lam W.W.T., Byrne J. and Chan G.C.F., Assoication of colour with emotional state and sensation among Cantonese speaking children aged 3-8 years, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 13.

Chu C.H., Nair G.R. and Chan G.C.F., Orofacial complications in children undergoing cancer therapy in Hong Kong, Hong Kong Dental Journal. 2005, 2: 102-105.

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Genetic thrombophilic risk factors in Chinese children with malignant illness, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 66.

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilia Does Not Increase Catheter Thrombosis in Chinese Children with malignancies, 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 82.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Ha S.Y., Chik K.W., Ling S.C., Lee A.C.W., Luk C.W., Lam C.W.K., Ng I.O.L. and Chan G.C.F., A randomized controlled study evaluating the safety and efficacy of deferiprone treatment in thalassemia major patients from Hong Kong, Hemoglobin. 2006, 30(2): 263-274.

Ha S.Y., Chan G.C.F., Chiang A.K.S., Lee A.C.W., Lee T.L. and Lau Y.L., Bone Marrow Transplantation for Fanconi Anaemia Using a Fludarabine-based Preparative Regimen with CD34+ Cell Selection, Hong Kong Journal of Paediatrics (new series). 2006, 11: 39-44.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Khong P.L., Leung L.H.T., Fung A.S.M., Fong D.Y.T., Qiu D., Kwong D.L.W., Ooi C.G.C., McAlonan G.M., Cao G. and Chan G.C.F., White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function, Journal of Clinical Oncology. 2006, 24(6): 884-890.

Lee A.C.W., Shing M.M.K., Ling S.C., Chan G.C.F. and Yuen H.L., Haemophilia B: Should We Stop Using Prothrombin Complex Concentrates in Hong Kong?, Hong Kong Journal of Paediatrics (new series). 2006, 11: 50-54.

Leung A.Y.H., Wong A.S.Y., Chan G.C.F., Yuen K.Y. and Kwong Y.L., Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(6): 621-3.

Li C.K., Chik K.W., Ha S.Y., Lee A.C., Yuen H.L., Ling S.C., Lee V., Chan G.C.F., Shing M.M., Chan L.C. and Ng M.H., Improved outcome of acute lymphoblastic leukaemia treated by delayed intensification in Hong Kong children: HKALL97 study, Hong Kong Medical Journal. 2006, 12(1): 33-9.

Li J., Law H.K.W., Lau Y.L. and Chan G.C.F., Different in vitro effects of chemotherapeutic agents on human mesenchymal stem cells, The Proceedings of The 10^th Congress of Bone Marrow Transplant Centre, The First Affiliated Hospital of Zhejiang University, Hangzhou, China, 13-16 October 2005. 61.

Li J., Kwong D.L.W. and Chan G.C.F., Short term and prolonged effects of irradiation on human mesenchymal stem cells, Biology of Blood and Marrow Transplantation (Abstracts from the 2006 BMT Tandem Meetings), Honolulu, Hawaii, February 2006. 12(2): 108.

Ling S.C., Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Chan C.W., Lee C.Y., Kwong K.S. and Li C.K., Children and Adolescents with Haemophilia in Hong Kong: An Epidemiological and Clinical Review, Hong Kong Journal of Pediatrics (new series). 2006, 11: 13-19.

Ma E.S.K., Li Y.H., Kwok J.S.Y., Ling S.C., Yau P.W. and Chan G.C.F., ADAMTS13 Mutational Analysis in Chinese Patients with Chronic Relapsing Thrombotic Thrombocytopenic Purpura, Hong Kong Journal of Paediatrics (new series). 2006, 11: 22-27.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

Qiu D., Leung L.H.T., Kwong D.L.W., Chan G.C.F. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, NeuroImage. 2006, 31: 109-115.

Yip H.K., Jin C., Chan S., Zhang T., Wong W.H.S., Fang H.H.P. and Chan G.C.F., Titanium Surface Treatments and Growth of Human Mesenchyamal Stem Cells, Journal of Dental Research, 35th the AADR/CADR Annual Meeting & Exhibition, March 3-9, 2006, Orlando, Florida, USA. USA, International Association for Dental Research, 2006, abstract no. 2008.

Yip S.F., Wan T.S.K., Chan L.C. and Chan G.C.F., Trisomy 4 as sole karyotypic abnormality in acute lymphoblastic leukemia: Different clinical features and treatment response between B and T phenotypes?, Cancer Genetics and Cytogenetics. 2006, 164: 94-95.

Researcher : Chan GLH

List of Research Outputs

Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Discrepant FA reduction between the frontal and parietal lobes of post irradiation medulloblastoma survivors: preliminary findings of regional susceptibility?, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006.

Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006.

Researcher : Chan KW

List of Research Outputs

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Chan S.Y., Chan K.W., Yick L.W. and Fong S.W., Transgenic expression of testis specific protein Y-encoded-like 2 triggers developmental and behavioral changes, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S117.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Downregulation of Testis Specific Protein Y-encoded like 2 in neonatal heart development, 15^th International Soceity of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S54.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Regulation of testis specific protein Y-encoded like 2, a member of nucleosome assembly proteins, in neonatal heart development, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 105.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis for putative transcription factor binding sites of a novel hypoxic-ischaemic regulated gene - HID-1, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 61.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis of putative promoter sequences of known and novel genes identified by hpoxic-ischaemic insult, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 118.

Ip P., Goh W.H.S., Chan K.W. and Cheung P.T., A Chinese boy with progressing joint contractures, dystonia and psychomotor regression: A novel FUCA 1 mutation causing fucosidosis, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 56.

Yam J.W.P., Chan K.W., Ngan E.S.W. and Hsiao W.L., Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene., Gene. 2005, 357: 55-62.

Researcher : Chan KW

List of Research Outputs

Yam J.W.P., Chan K.W., Ngan E.S.W. and Hsiao W.L., Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene., Gene. 2005, 357: 55-62.

Researcher : Chan S

List of Research Outputs

Yip H.K., Jin C., Chan S., Zhang T., Wong W.H.S., Fang H.H.P. and Chan G.C.F., Titanium Surface Treatments and Growth of Human Mesenchyamal Stem Cells, Journal of Dental Research, 35th the AADR/CADR Annual Meeting & Exhibition, March 3-9, 2006, Orlando, Florida, USA. USA, International Association for Dental Research, 2006, abstract no. 2008.

Researcher : Chan SY

Project Title:	Functional studies of the role of NAP79 in the development of the heart
Investigator(s):	Chan SY, Zhang JCL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

To test the function of NAP79 in heart development by the generation of null-mutant mice. The focus of the phenotype analysis will be on cardiomyocyte proliferation and terminal differentitation.

Project Title:	Functional studies of the role of NAP79 in the development of the heart
Investigator(s):	Chan SY, Zhang JCL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

Project Title:	Signal transduction by RET receptor tyrosine kinase and MEN2B-RET
Investigator(s):	Chan SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To investigate some proteins which are phosphorylated at the tyrosine residue after stimulation by RET ligands, are bona fide RET downstream signalling molecules by various approaches; to use the approach of mass spectrometry to search for serine-, tyrosine- phosphorylated proteins that are substrates for RET-MEN2B, the mutant RET found in MEN2B patients.

Project Title:	Expression and function of NAP79 during brain development.
Investigator(s):	Chan SY, Yick LW
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

Background: Our group has identified a novel 79 kDa nucleosome assembly protein, NAP79, from human heart cDNAs. We have generated transgenic lines of mice expressing human NAP79 in the heart and brain. Nucleosome assembly proteins (NAPs) deposit histones onto DNA, which is important in nucleosome remodelling during DNA replication and gene transcription, and in controlling mitotic events. A role of NAPs in inhibiting cell proliferation is demonstrated by the inactivation of NAP1-like-2 in mice, which leads to an opened neural tube, and exposed brain. These defects are associated with overproduction of neuronal precursor cells. A few months ago, NAP79 is found to form a complex with CASK and Tbr-1 to modulate the expression of NMDA receptor subunit 2B (NR2b) in cultured hippocampal neurons. NAP79 encodes a novel protein containing a conserved NAP domain, potential phosphorylation sites for casein kinase II, cyclin-dependent kinases, and cAMP- and cGMP-dependent kinases. During postnatal development, we have found that NAP79 expression in cardiomyocytes changes as they exit from the cell cycle. Furthermore, NAP79 arrests cell proliferation when transfected into HeLa cells or yeast. These data suggest that NAP79 plays a role in regulating the proliferation and differentiation of cardiomyocytes. Also, our northern and western blot data has shown that NAP79 is highly expressed in the adult brain but not in other organs. Like the heart, the adult brain consists mostly of non-dividing post-mitotic cells. Objectives: We hypothesize that (1) NAP79 is essential for switching off cell proliferation during brain development; and/or (2) NAP79 controls brain function through controlling the expression of specific target genes. In this proposal we seek to investigate the expression and function of NAP79 during the development of the mammalian central nervous system (CNS). We shall also characterize the cell types expressing human NAP79 in the transgenic mouse brain. For elucidation of gene function, phenotype analysis of the NAP79 transgenic animals including expression of target genes (eg. NR2b), behavioural, learning and memory test will form the basis of a new RGC proposal.

Project Title:	Role of NAP79 in cardiomyocyte proliferation and differentiation
Investigator(s):	Chan SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

List of Research Outputs

Chan S.Y., External Adviser, Fourth Research Postgraduate Retreat, Department of Pathology, HKU, 22 April 2006. 2006.

Chan S.Y., Microinjection And Transgenesis, Final year coruse on 'Reproduction' offered by the Department of Zoology . 2005.

Chan S.Y., Stem Cells And Animal Cloning, Final year coruse on 'Reproduction' offered by the Department of Zoology . 2005.

Chan S.Y., Chan K.W., Yick L.W. and Fong S.W., Transgenic expression of testis specific protein Y-encoded-like 2 triggers developmental and behavioral changes, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S117.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Downregulation of Testis Specific Protein Y-encoded like 2 in neonatal heart development, 15^th International Soceity of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S54.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Regulation of testis specific protein Y-encoded like 2, a member of nucleosome assembly proteins, in neonatal heart development, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 105.

Lee R.H.K., Wong W.L., Chan C.H. and Chan S.Y., Differential Effects of Glial Cell Line-Derived Neurotrophic Factor and Neurturin in RET / GFRa1-Expressing Cells, Journal of Neuroscience Research. Wiley InterScience, 2006, 83: 80-90.

Liang Y. and Chan S.Y., SUN2, a nuclear envelope protein protein associated with muscuclar disorders, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 76.

Liang Y. and Chan S.Y., Subcellular localization of sun2 is mediated by lamin and rab5, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 107.

Researcher : Chan WK

List of Research Outputs

Chan C., Chan W.K., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium extract can enhance maturation of human monocyte-derived dendritic cells, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 577.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Immunopotent Polysaccharides of Different Sources Selectively Activate Human Dendritic Cells, Blood. 2005, 106(11): 49b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Lingzhi polysaccharides can activate human dendritic cells maturation, 2005年全國小兒血液/腫瘤學術會議, Hangzhou, PR China, 9-13 October 2005, Hangzhou, PR China, 2005, 84-85.

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Researcher : Chau AKT

List of Research Outputs

Chau A.K.T., Chung B.H.Y., Lun K.S., Cheung Y.F. and Yung T.C., Midterm Outcomes of Transcatheter Closure of Atrial Septal Defect Using the Amplatzer Septal Occluder in Children, Hong Kong Journal of Paediatrics (new series). 2005, 10: 251-256.

Chau A.K.T., Stent Implantation in Congenital Heart Disease: A New Therapeutic Modality, Hong Kong Journal of Paediatrics (new series). 2005, 10: 286-298.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 54-55.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 48.

Cheung E.W.Y., Chiu S.W., Chau A.K.T. and Cheung Y.F., Plasma brain natriuretic peptide level relates to pulmonary regurgitation, right ventricular dilation and exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 69.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 2005 年全國小兒心血管疾病學術會議, 海南, 中國, 2005, 44-45.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 1^st Congress of Asiang Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 95.

Cheung Y.F., Chau A.K.T., Yung T.C. and Lun K.S., Transcatheter Closure of Right-to-Left Atrial Shunts Using Amplatzer Septal Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 265-270.

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Chow P.C., Lun K.S. and Chau A.K.T., Pulmonary vascular complications in children with chronic liver diseases, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 57.

Hui L., Chau A.K.T., Leung M.P. and Cheung Y.F., Dobutamine stress echocardiographic assessment of left ventricular function long after intervention for coronary artery fistula, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(SupplA): 243A.

Lun K.S., Chau A.K.T., Yung T.C., Cheung Y.F., Cheng L.C. and Chiu C.S.W., Are we aggressive enough to treat acute fulminant myocarditis?, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 72.

Lun K.S., Chiu C.S.W., Yung T.C., Cheung Y.F., Cheng L.C., Chau A.K.T. and Chau A.K.T., Intermediate-term Results of Repair of Congenital Heart Diseases Using Pulmonary Homografts, Hong Kong Journal of Paediatrics (new series). 2005, 10: 271-281.

Tam C.K.M., Lun K.S., Chau E.M.C. and Chau A.K.T., Sildenafil in the Management of Childhood Severe Idiopathic Pulmonary Arterial Hypertension: A Case Report, Hong Kong Journal of Paediatrics (new series). 2005, 10: 307-310.

Tsang F.H.F., Cheng L.C., Yung T.C., Chau A.K.T. and Chiu C.S.W., Ligation of Patent Ductus Arteriosus for Premature Infants in Intensive Care Unit, Hong Kong Journal of Paediatrics (new series). 2005, 10: 282-285.

Wong K.T., Chau A.K.T., Cheung Y.F., Yung T.C. and Lun K.S., Midterm Results of Transcatheter Closure of Moderate to Large-sized Patent Ductus Arteriosus Using the Amplatzer Duct Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 245-250.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Wong K.T., Yung T.C., Lun K.S., Fan K.Y.Y. and Chau A.K.T., Ten-year Experience of Radiofrequency Catheter Ablation of Accessory Pathways in Children and Young Adults, Hong Kong Journal of Paediatrics (new series). 2005, 10: 257-264.

Wong K.T., Yung T.C., Lun K.S., Fan K. and Chau A.K.T., Transcatheter radiofrequency ablation of supraventricular tachycardia in children and adolescents - immediate results and mid-term follow-up, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 71.

Researcher : Chay GW

List of Research Outputs

Cheung E.W.Y., Chay G.W., Ma E.S.K. and Cheung Y.F., Systemic Oxygen Saturation and Coagulation Factor Abnormalities Before and After the Fontan Procedure, The American Journal of Cardiology. 2005, 96: 1571-1575.

Cheung Y.F., Chay G.W. and Ma E.S.K., Ethnic Differences in Coagulation Factor Abnormalities After the Fontan Procedure, Pediatric Cardiology. 2006, 27: 96-101.

Researcher : Chen T

List of Research Outputs

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Researcher : Chen W

List of Research Outputs

Chen W., Wong V.C.N. and Wong K.Y., Electrophysiologic and neurodevelopmental outcomes in neonate with hyperbilirubinemia, 10th Research Postgraduate Symposium, organized by the Faculty of Medicine, HKU (3 December, 2005). 2005.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental Outcome of Severe Neonatal Hemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(6): 474-479.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 39.

Chen W. and Wong V.C.N., Prognosis of Bell's Palsy in children - an analysis of 29 cases, Brain & Development. 2005, 27(7): 504-508.

Chen W. and Wong V.C.N., Prognosis of Bell's palsy in children - Analysis of 29 cases, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 41.

Chen W., Wong V.C.N. and Wong K.Y., Short and long term outcome of severe neonatal non-hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 40.

Chen W. and Wong V.C.N., Visual Evoked Potentials in Neonatal Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(1): 58-62.

Chen W. and Wong V.C.N., Visual evoked potentials in neonatal hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 42.

Wong V.C.N., Chen W. and Wong K.Y., Short- and Long-Term Outcome of Severe Neonatal Nonhemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21: 309-315.

Researcher : Chen W

List of Research Outputs

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental Outcome of Severe Neonatal Hemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(6): 474-479.

Chen W. and Wong V.C.N., Prognosis of Bell's Palsy in children - an analysis of 29 cases, Brain & Development. 2005, 27(7): 504-508.

Chen W. and Wong V.C.N., Visual Evoked Potentials in Neonatal Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(1): 58-62.

Wong V.C.N., Chen W. and Wong K.Y., Short- and Long-Term Outcome of Severe Neonatal Nonhemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21: 309-315.

Researcher : Cheng M

Project Title:	The role of pro-inflammatory cytokines in matrix metalloproteinase (MMP) expression
Investigator(s):	Cheng M, Lau ASY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	10/2005
Completion Date:	09/2006

Abstract:

Objectives: 1. To characterize matrix metalloproteinases (MMPs) expression of tumor cell lines in response to various cytokines 2. To understand the effects of cytokine interactions on MMPs expression and tumor cell invasion Background and Significance: Matrix metalloproteinases (MMPs) (1) have gained considerable attention in cancer research due to their capabilities of degrading the ECM and thus facilitating tumor cell invasion (2). As excess MMPs production and activation have been implicated to play pathological roles in a variety of disease processes, including rheumatoid arthritis, atherosclerosis, and tumor invasion or metastasis (3-5), strict regulation of MMPs expression is therefore critical in maintaining the proper ECM homeostasis. Various tissue derived factors including cytokines have been implicated to play a role in the regulatory process. Cytokine including interferon (IFN) and tumor necrosis factor (TNF) are signaling molecules that are released in response to a diverse range of cellular stresses, including inflammation, infection, and immunity (6). Previous reports including ours have demonstrated that TNF functions as a tumor suppressor and an inducer of apoptosis (7, 8). Recently, several lines of evidence suggested that cytokines produced by infiltrating leukocytes can modulate tumor cells to produce more MMPs (9, 10). In addition, a growing evidence in clinical data suggested a correlation between leukocyte infiltration with poor outcome (11, 12) and cancer dissemination (13, 14). These observations suggested the possibility that host-derived cytokines may facilitate invasion and metastasis. Is it possible that the interaction of pro-inflammatory cytokines, produced in the tumor microenvironment, has an important role in cancer dissemination? If so, can therapies that are directed at reducing or inhibiting the function of inflammatory cytokines in attempts to reduce tumor cell invasion? Here, we hypothesize that (i) cytokines present in the microenvironment can facilitate the spread of tumor cells by induction of different MMPs. (ii) Therapeutic manipulations that are aimed to attenuate excessive cytokine action which might reduce the rate of tumor cell invasion. In delineating the interactions of this proteolytic system (i.e. MMP) and cytokines, we will gain better insights into the cause of cancer cell metastasis. In addition, the results can help us to clarify whether cytokine-mediated MMP-inhibition can be a part of future strategies against cancer invasion. References: 1. Brinckerhoff, C. E., and L. M. Matrisian. 2002. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3:207. 2. Friedl, P., and K. Wolf. 2003. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3:362. 3. Ye, S., P. Eriksson, A. Hamsten, M. Kurkinen, S. E. Humphries, and A. M. Henney. 1996. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J Biol Chem 271:13055. 4. Dayer, J. M., R. Graham, G. Russell, and S. M. Krane. 1977. Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science 195:181. 5. Lynch, C. C., and L. M. Matrisian. 2002. Matrix metalloproteinases in tumor-host cell communication. Differentiation 70:561. 6. Balkwill, F. R., and F. Burke. 1989. The cytokine network. Immunol Today 10:299. 7. Yeung, M. C., J. Liu, and A. S. Lau. 1996. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells. Proc Natl Acad Sci U S A 93:12451. 8. Clemens, M. J., and U. A. Bommer. 1999. Translational control: the cancer connection. Int J Biochem Cell Biol 31:1. 9. Warner, R. L., N. Bhagavathula, K. C. Nerusu, H. Lateef, E. Younkin, K. J. Johnson, and J. Varani. 2004. Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro. Exp Mol Pathol 76:189. 10. Witek-Zawada, B., and A. Koj. 2003. Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes. J Physiol Pharmacol 54:489. 11. Coussens, L. M., and Z. Werb. 2001. Inflammatory cells and cancer: think different! J Exp Med 193:F23. 12. Coussens, L. M., and Z. Werb. 2002. Inflammation and cancer. Nature 420:860. 13. Perissinotto, E., G. Cavalloni, F. Leone, V. Fonsato, S. Mitola, G. Grignani, N. Surrenti, D. Sangiolo, F. Bussolino, W. Piacibello, and M. Aglietta. 2005. Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. Clin Cancer Res 11:490. 14. Prime, S. S., J. W. Eveson, A. M. Stone, S. P. Huntley, M. Davies, I. C. Paterson, and C. M. Robinson. 2004. Metastatic dissemination of human malignant oral keratinocyte cell lines following orthotopic transplantation reflects response to TGF-beta 1. J Pathol 203:927. 15. Li, J. C., D. C. Lee, B. K. Cheung, and A. S. Lau. 2005. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response. FEBS Lett 579:3055.

List of Research Outputs

Researcher : Cheung BKW

List of Research Outputs

Cheung B.K.W., Lee D.C.W., Li C.B., Lau Y.L. and Lau Y.L., A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression, Journal of Immunology. 2005, 175(11): 7218-7225.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-Stranded RNA-Activated Protein Kinase PKR in Bacillus Calmette Guerin (BCG)-Induced Cell Death, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 289.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-stranded RNA-activated Protein Kinase PKR in Bacillus Calmétte Guerin (BCG)-induced Cell Death., In: Benny K.W. Cheung, Davy C.W. Lee and Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Cheung B.K.W. and Lau A.S.Y., Signaling pathways in mycobacterial infection: Involvement of Toll-like receptors., In: BKW Cheung, and AS Lau., 10th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong.. 2005.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 211.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Resersch (Program & Abstracts from the 2005 Annual meeting of International Society for Interferon and cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10): 211.

Researcher : Cheung EWY

List of Research Outputs

Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., Cardiovascular magnetic resonance imaging derived right ventricular volume and pulmonary regurgitant fraction relate to exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 70.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 54-55.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 48.

Cheung E.W.Y., Chiu S.W., Chau A.K.T. and Cheung Y.F., Plasma brain natriuretic peptide level relates to pulmonary regurgitation, right ventricular dilation and exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 69.

Cheung E.W.Y. and Cheung Y.F., Relation between plasma brain natriuretic peptide, right ventricular function and exercise capacity in patients after surgical repair of tetralogy of fallot, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4), (SupplA): 240A-241A.

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 55-56.

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Cheung E.W.Y., Chay G.W., Ma E.S.K. and Cheung Y.F., Systemic Oxygen Saturation and Coagulation Factor Abnormalities Before and After the Fontan Procedure, The American Journal of Cardiology. 2005, 96: 1571-1575.

Cheung E.W.Y. and Cheung Y.F., Systemic oxygen saturation and coagulation factor abnormalities before and after the fontan procedure, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(Suppl A): 244A.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 2005 年全國小兒心血管疾病學術會議, 海南, 中國, 2005, 44-45.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 1^st Congress of Asiang Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 95.

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Researcher : Cheung PT

Project Title:	Delineation of molecular genetic basis for patients with idiopathic short stature
Investigator(s):	Cheung PT, Low LCK
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Abstract:

To determine the measurable biochemical profile in a group of patients with ISS and delineate the detailed genetic workup of the stated target genes.

List of Research Outputs

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Automated method for the identification of conserved non-coding regions in hypoxic-ischaemic regulated genes in different species, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic piepline for the identification of transcription factor binding sites in mouse and human, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 93.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic pipeline for the identification of transcription factor binding sites in mouse and human, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 58.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis for putative transcription factor binding sites of a novel hypoxic-ischaemic regulated gene - HID-1, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 61.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis of putative promoter sequences of known and novel genes identified by hpoxic-ischaemic insult, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 118.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Ip P., Goh W.H.S., Chan K.W. and Cheung P.T., A Chinese boy with progressing joint contractures, dystonia and psychomotor regression: A novel FUCA 1 mutation causing fucosidosis, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 56.

Khong P.L., Wang Y., Qiu D., Shen G.G., Wu E.X. and Cheung P.T., MRI for the prediction of irreversible infarct size in neonatal rat brain after hypoxic-ischemic injury, Society of Paediatric Radiology and European Society of Paediatric Radiology's Fifth Conjoint Meeting, Montreal, Canada, 18-20 May 2006.

So K.F., Yick L.W., Cheung P.T. and Wu W., Combined treatment of lithium chloride and chondroitinase ABC, First International Spinal Cord Injury Treatments & Trials Symposium (ISCITT), December 17-20, Hong Kong. 2005, 43.

Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54.

Researcher : Cheung YF

Project Title:	CSX/NKX2.5 mutations in patients with pulmonary atresia and intact ventricular septum
Investigator(s):	Cheung YF, Chan SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To determine the possible genetic cause of PAIVS, which is a relatively common cyanotic congenital heart disease in this locality.

Project Title:	Development of a multimedia tool for teaching of paediatric cardiology
Investigator(s):	Cheung YF
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Run Run Shaw Research and Teaching Endowment Fund - Teaching Grants
Start Date:	04/2004

Abstract:

To improve the knowledge on congenital heart disease of medical students; thier skills in the evaluation of children with congenital heart disease, and their skills in counseling of parents of paediatric cardiac patients.

Project Title:	Modulating effects of body defense molecule and inflammatory gene polymorphisms on arterial stiffness in Kawasaki disease
Investigator(s):	Cheung YF, Lau YL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To test the hypothesis that polymorphisms of these candidate genes, in isolation or combination, modulate systemic arterial stiffness in patients with a history of KD.

Project Title:	Association and linkage studies between arterial stiffness and the Fibrillin-1 gene
Investigator(s):	Cheung YF
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

Project Title:	Association and Linkage Studies Between Arterial Stiffness and the Fibrillin-1 Gene
Investigator(s):	Cheung YF, Lau YL, Sham PC
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Arterial stiffness is recently recognized as an independent cardiovascular risk factor. With arterial stiffening, the left ventricular afterload is increased while coronary perfusion is altered. The secondary increase in pulse pressure has further been shown to be an independent predictor of cardiovascular mortality and future cardiovascular events. Although arterial stiffening has traditionally been regarded as part of the normal aging process, there is growing evidence that it may precede clinical disease and predict a higher risk for developing atherosclerosis, hypertension and stroke. Recently, the genetic aspect of arterial stiffness is beginning to unveil. In particular, there is a growing body of evidence that suggests a contributory role of genetic variations in extracellular matrix proteins to arterial stiffening. Fibrillin-1, being a matrix glycoprotein and the principal constituent of microfibrils that provide load-bearing and anchoring functions within the arterial wall, is particularly relevant in this context. Indeed, mutation and polymorphism of the fibrillin-1 gene has been associated with aortic stiffening in patients with Marfan syndrome and brachial pulse pressure in a healthy middle-aged male population, respectively. Nonetheless, whether variations in the fibrillin-1 genotype contribute to arterial stiffness in the general population have hitherto remained unknown. The primary objective of the proposed study is to test the hypothesis that arterial stiffness in the general population is associated with variations in the fibrillin-1 genotype. To test the hypothesis, sibling pair association and linkage studies between arterial stiffness and fibrillin-1 gene will be performed. The central (aortic and carotid) and peripheral (brachio-radial) arterial stiffness will be related to demographic variables, cardiovascular risk factors and a variable nucleotide tandem repeat polymorphism in intron 28 of the fibrillin-1 gene. Additionally, the single nucleotide polymorphism at intron C in the upstream region of the fibrillin-1 gene will be determined. Based on findings of these studies, the following issues will be addressed: - heritability of central and peripheral conduit arterial stiffness - association between variations in fibrillin-1 genotypes and arterial stiffness - linkage between fibrillin-1 gene and arterial stiffness - gene-environment interaction of fibrillin-1 genotypic variations in relation to arterial stiffness

List of Research Outputs

Chau A.K.T., Chung B.H.Y., Lun K.S., Cheung Y.F. and Yung T.C., Midterm Outcomes of Transcatheter Closure of Atrial Septal Defect Using the Amplatzer Septal Occluder in Children, Hong Kong Journal of Paediatrics (new series). 2005, 10: 251-256.

Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., Cardiovascular magnetic resonance imaging derived right ventricular volume and pulmonary regurgitant fraction relate to exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 70.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 54-55.

Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 48.

Cheung E.W.Y., Chiu S.W., Chau A.K.T. and Cheung Y.F., Plasma brain natriuretic peptide level relates to pulmonary regurgitation, right ventricular dilation and exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 69.

Cheung E.W.Y. and Cheung Y.F., Relation between plasma brain natriuretic peptide, right ventricular function and exercise capacity in patients after surgical repair of tetralogy of fallot, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4), (SupplA): 240A-241A.

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 55-56.

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Cheung E.W.Y., Chay G.W., Ma E.S.K. and Cheung Y.F., Systemic Oxygen Saturation and Coagulation Factor Abnormalities Before and After the Fontan Procedure, The American Journal of Cardiology. 2005, 96: 1571-1575.

Cheung E.W.Y. and Cheung Y.F., Systemic oxygen saturation and coagulation factor abnormalities before and after the fontan procedure, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(Suppl A): 244A.

Cheung Y.F., Aortic Root of Dilation After Surgical Repair of Tetralogy of Fallot, Hong Kong College of Cardiology, Fourteenth Annual Scientific Congress Proceedings, Hong Kong, 5-7 May 2006.

Cheung Y.F., Arterial Stiffness in Children and Teenagers: An Emerging Cardiovascular Risk Factor, Hong Kong Journal of Paediatrics (new series). 2005, 10: 299-306.

Cheung Y.F., Chay G.W. and Ma E.S.K., Ethnic Differences in Coagulation Factor Abnormalities After the Fontan Procedure, Pediatric Cardiology. 2006, 27: 96-101.

Cheung Y.F., Karmin O., Tam S. and Siow Y.L., Induction of MCP1, CCR2, and iNOS Expression in THP-1 Macrophages by Serum of Children Late After Kawasaki Disease, Pediatric Research. 2005, 58(6): 1306-1310.

Cheung Y.F., Karmin O., Tam S. and Siow Y.L., MCP1, CCR2 and iNOS Induction in THP-1 Macrophages by Serum of Children Late After Kawasaki Disease, 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 91.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 2005 年全國小兒心血管疾病學術會議, 海南, 中國, 2005, 44-45.

Cheung Y.F., Cheung E.W.Y., Chau A.K.T. and Chiu C.S.W., Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair, 1^st Congress of Asiang Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 95.

Cheung Y.F., Chau A.K.T., Yung T.C. and Lun K.S., Transcatheter Closure of Right-to-Left Atrial Shunts Using Amplatzer Septal Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 265-270.

Cheung Y.F., Vascular Dysfunction after Kawasaki Disease: Implications for Long-term Follow-up, 6^th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 7-8.

Cheung Y.F., 川崎病患兒動脈僵硬度及影響因素, 上海市小兒心血管學術交流會, 上海, 中國, 15-17 December 2005, 2005.

Chong W.P., Wong W.H.S., Chiu C.S. and Cheung Y.F., Aortic Root Dilation is Related to Aortic Stiffening in Children after Repair of Tetralogy of Fallot, Supplement to Circulation (Abstract from American Heart Association, Scientific sessions 2005, Dallas, Texas, USA), 13-16 November 2005. 112(17): 2288.

Chong W.Y., Wong W.H.S., Chiu C.S.W. and Cheung Y.F., Aortic Root Dilation and Aortic Elastic Properties in Children After Repair of Tetralogy of Fallot, The American Journal of Cardiology. 2006, 97: 905-909.

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 56.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Hui L., Chau A.K.T., Leung M.P. and Cheung Y.F., Dobutamine stress echocardiographic assessment of left ventricular function long after intervention for coronary artery fistula, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(SupplA): 243A.

Lun K.S., Chau A.K.T., Yung T.C., Cheung Y.F., Cheng L.C. and Chiu C.S.W., Are we aggressive enough to treat acute fulminant myocarditis?, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 72.

Lun K.S., Chiu C.S.W., Yung T.C., Cheung Y.F., Cheng L.C., Chau A.K.T. and Chau A.K.T., Intermediate-term Results of Repair of Congenital Heart Diseases Using Pulmonary Homografts, Hong Kong Journal of Paediatrics (new series). 2005, 10: 271-281.

Mi Y. and Cheung Y.F., Assessment of right and left ventricular function by tissue Doppler echocardiography in patients after biventricular repair of pulmonary atresia with intact ventricular septum, International Journal of Cardiology. 2006, 109: 329-334.

Wong K.T., Chau A.K.T., Cheung Y.F., Yung T.C. and Lun K.S., Midterm Results of Transcatheter Closure of Moderate to Large-sized Patent Ductus Arteriosus Using the Amplatzer Duct Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 245-250.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Researcher : Chiang AKS

Project Title:	Experimental immunotherapy of tumours
Investigator(s):	Chiang AKS
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Research Initiation Programme
Start Date:	04/2001

Abstract:

To develop strategies in enhancing the host immune response against tumours.

Project Title:	Genetic studies of tubercubosis
Investigator(s):	Chiang AKS, Tang N., Yew W.W., Tam C.M.
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	03/2002

Abstract:

To host susceptibility genes in tubercubosis; to study pharmacogenomics in anti-tubercubosis drug metabolism.

Project Title:	Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children
Investigator(s):	Chiang AKS, Chan KH
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2003

Abstract:

An unresolved issue in EBV immunology concerns the relationship between clinical IM-like symtoms, virus DNA load and CD8+ T cell lymphocytosis; Acute IM in adolescents is associated with large expansions of EBV lytic epitope reactivities which are followed by a later expansion of latent epitope responses. The magnitude of the EBV lytic and latent epitope reactivities would be studied and compared in both IM and non-IM patients; likewise, is there a difference in the rate of emergence of latent epitope responses bewteen the IM and non -IM patients? The kinetics and evolution of the EBV epitope-specific cytotoxic T-lymphocyte (CTL) responses from primary to persistent phases of EBV infection would be compared between the two groups of children.

Project Title:	Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children
Investigator(s):	Chiang AKS, Chan KH
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	10/2003

Abstract:

N/A

Project Title:	Host susceptibility genes in tuberculosis
Investigator(s):	Chiang AKS, Lau YL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To investigate the genetic susceptibility of the Chinese population to tuberculosis.

Project Title:	Prospective study of Epstein-Barr virus (EBV) strains in primary EBV infection
Investigator(s):	Chiang AKS
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study the occurrence of Epstein-Barr virus (EBV) diversity and coinfection in a prospective study of primary Epstein-Barr virus infection in Chinese children.

Project Title:	Longitudinal study of Epstein-Barr virus specific antibody responses in childhood infectious mononucleosis
Investigator(s):	Chiang AKS, Chan KH
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Abstract:

The purpose of the proposed study is to compare the evolution of Epstein-Barr virus (EBV) specific antibody responses in a longitudinal followup study of symptomatic and asymptomatic primary EBV infection. What is known about EBV antibody responses in the literature? Epstein-Barr virus (EBV) infects greater than 90% of all human populations and establishes a lifelong persistence within the host. Primary infections by EBV may remain silent or induce a self-limiting lymphoproliferative disorder, infectious mononucleosis (IM). EBV-encoded antigens are divided into those expressed in the viral replicative cycle, i.e., the viral capsid antigen (VCA) and the early amtigens (EA) of the diffuse (D) and the restricted (R) varieties and those expressed in the viral latent cycle, the EBV-determined nuclear antigen (EBNA). The different timing of emergence between the antibodies to VCA and EA and those to EBNA indicates that the two sets of antigens are likely expressed on separate types of cells which become available to stimulate antibody responses under different circumstances. The laboratory diagnosis of EBV infection is based on serological tests to detect both specific antibodies to EBV antigens (1, 2) and heterophile antibodies (3, 4). At the onset of symptoms of IM, the humoral response to EBV infection is characterized by the presence of VCA IgM antibodies and the concurrent rise of VCA IgG antibodies (5). Antibodies to diffuse early antigen (anti-EA-D) are transitory and are detected in about 80% of infected persons. Antibodies to EA-R may become detectable in protracted cases of the disease after the anti-D titres have subsided. Anti-EBNA IgG can usually be detected at a later stage at several weeks to months after the the onset of symptoms. The majority of adult IM patients also develop IgM heterophile antibodies of the Paul-Bunnell type but the reason for their transient emergence is unknown. However, these heterophile antibodies are absent in the majority of children under 4 years of age (6). The antibody responses in silent primary EBV infections (more frequently occurred in children than adults) largely conform to those seen in IM except that antibodies to the EA complex are directed against R instead of D (7, 8). The early EBV-specific IgG antibody response after primary infection is made up of low avidity antibodies. The avidity increases in the few weeks to several months after the infection (9, 10). This property of the humoral IgG response has been employed in serological assays to distinguish between primary and re-infection or reactivation of different viruses such as rubella, CMV and parvovirus (11, 12, 13). Key issues: The pattern of antibody responses and the antibody levels to EBV-encoded antigens are largely derived from cross sectional studies of large number of individuals. Longitudinal serology data of persons recovering from IM is seldom available and information on the humoral response in asymptomatic EBV infection is scanty. I have followed a large number of Chinese children presenting with infectious mononucleosis and some children who are found to have asymptomatic primary EBV infection from the time of onset of infection through convalescence to persistence. It offers an opportunity to compare the natural evolution of antibody responses against EBV in symptomatic and asymptomatic infections. Project objectives: 1. To define the evolution of the humoral response against a human persistent virus. 2. To study the maturation of the humoral response against a persistent virus in terms of antibody avidity. 3. To compare the magnitude and the quality of the humoral response against viral lytic and latent EBV antigens from acute phase through convalescent to persistent phase in symptomatic and asymptomatic infections. References: 1.Henle W and Henle G: Epstein-Barr virus specific serology in immunologically compromized individuals. Cancer Res 41: 4222-4225, 1981 2.Henle W and Henle G: Immunology of Epstein-Barr virus. In: B, Roizman (Ed.), The Herpsesviruses, Vol. 1. Plenum Publishing Corp., Ne York, pp 209-252, 1982 3.Paul JR and Bunnell WW: The presence of heterophile antibodies in infecetious mononucleosis. Am J Med Sci 183: 90-104, 1932 4.Davidsohn I and Lee CL: The clinical serology of infectious mononucleosis. In: RL Carter and HG Penman (Eds.), Infectious Mononucleosis. Blackwell Scientific Publications, Ltd., Oxford, pp 177-200, 1969 5.Okano M, Thiele GM, Davis JR, Grierson HL, Purtilo DT: Epstein-Barr virus and human diseases: recent advances in disgnosis. Clin Microbiol Rev 1: 300-312, 1988 6.Sumaya CV: Infectious mononucleosis and other EBV infections: diagnostic factors. Lab Manag 24: 37-45, 1986 7.Biggar RJ, Henle G, Bocker J, Lennette ET, Fleisher G, Henle W: Primary Epstein-Barr virus infections in African infacnts. II. Clinical and serological obsevations during seroconversion. Int J cancer 22: 244-250, 1978 8.Fleisher G, Henle W, Henle G, Lennette ET, Biggar RJ: Primary Epstein-Barr virus infection in American infants: clinical and serological observations. J Infect Dis 139: 553-558, 1979 9.Inouye S, Hasegawa A, MAtsuno S, Katwo S: Changes in antibody avidity after virus infections: detection by an immunosorbent assay in which a mild protein-denaturing agent is employed. J Clin Microbiol 20: 525-529, 1984 10.Kocks C and Rajewsky K: Stepwise intracloncal maturation of antibody affinity through somatic hypermutation. Proc Nat Acad Sci USA 85: 8206-8210, 1988 11.Thomas HIJ and Morgan-Capner P: Rubella-specific IgG subclass avidity and its role in differenetiation between primary rubella and rubella reinfection. Epidemiol Infect 101: 591-598, 1988 12.Lutz E, Ward KN, Gray JJ: Maturation of antibody avidity after primary human cytomegalovirus infection is delayed in immunosuppressed solid organ transplant patients. J Med Virol 44: 317-322, 1994 13.Gray JJ, Cohen BJ, Dresselberger U: Detection of human parvirus B19-specific IgM and IgG sntibodies using a recombinant viral VP1 antigen expressed in insect cells and estimation of time of infection by testing for antibody avidity. J Virol Methods 44: 11-24, 1993

List of Research Outputs

Cheuk D.K.L., Lee T.L., Ha S.Y., Chan G.C.F., Lau Y.L. and Chiang A.K.S., Bone Marrow Transplantation for Hepatitis-associated Aplastic Anaemia: Case Reports and a Review of the Literature, Hong Kong Journal of Paediatrics (new series). 2006, 11: 32-38.

Cheuk D.K.L., Lee A.C.W., Chiang A.K.S., Ho M.H.K., Ha S.Y., Chan G.C.F. and Lau Y.L., Quality of life study on transfusion-dependent thalassemic patients in Hong Kong, 10^th International Conference on Thalassaemia & Haemoglobinopathies & 12^th International TIF Conference for Thalassaemia Patients and Parents, Dubai, United Arab Emirates, 7-10 January 2006. 148.

Chiang A.K.S., Wong O.H. and Huang F., Functional Comparison of Cord and Adult Blood-Derived Dendritic Cells, Journal of Pediatric Haematology Oncology (Abstract published in the conference proceedings for 1^st Annual Fall Conference, Vancouver, Canada, 19-22 September 2005. 27(9): 463.

Chiang A.K.S., Infectious Mononucleosis in Hong Kong Chinese Children, Symposium on Epstein Barr Virus - associated Chronic Active Infection and Hemophagocytic Syndrome, National Health Research Institutes, Chunan, Taiwan, 10 October 2005. A-1.

Chiang A.K.S., Paediatric lymphoma & solid tumour II: soft tissue sarcoma, renal tumour, liveer tumour in children, "Pediatric Oncology for Health Care Professionals" course organized by SPACE, HKU, 8 June 2006. 2006.

Chiang A.K.S. and Chan K.H., Prospective studies on primary EBV infection in Chinese children, The Croucher Foundation Advanced Study Institute on Epstein-Barr Virus and Nasopharyngeal Carcinoma organized by The University of Hong Kong and The Hong Kong University of Science and Technology, Hong Kong, 23-27 January 2006.

Chiang A.K.S., Review of malignant liver tumours, Hong Kong Paediatric Haematology & Oncology Study Group, Hong Kong, 5 December 2005. 2005.

Chiang A.K.S., Lee P.P.W., Li C.K., Yuen H.L., Lee A.C.W. and Li C.K., Treatment outcome of hepatocellular carcinoma and hepatoblastoma in children in Hong Kong, The 4^th congress of the International Society of Pediatric Oncology-Asia, Shanghai, PR China, 6-8 April 2006. 68.

Chiang A.K.S., Lee A.C.W., Shing M.M.K., Yuen H.L. and Li C.K., Treatment outcome of lymphoblastic lymphomas in children in Hong Kong, Pediatric Blood & Cancer (Abstracts published for Second International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma, New York, USA, 18-20 May 2006). 2006, 46: 866.

Chiang A.K.S., Two pediatric liver cancers respond very differently to chemotherapy, Oncology Times. USA, 2006, XXXVIII(11): 26.

Chiang A.K.S., Wong O.H. and Huang F., Update on non-Hodgkin lymphomas, The Hong Kong Society of Haematology Monthly Scientific Meeting, Hong Kong, 15 August 2005.

Ha S.Y., Chan G.C.F., Chiang A.K.S., Lee A.C.W., Lee T.L. and Lau Y.L., Bone Marrow Transplantation for Fanconi Anaemia Using a Fludarabine-based Preparative Regimen with CD34+ Cell Selection, Hong Kong Journal of Paediatrics (new series). 2006, 11: 39-44.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Lee A.C.W., Chiang A.K.S., Shing M.M.K., Yuen H.L. and Li C.K., Treatment of Paediatric Non-Hodkin's Lymphoma: A Report of the Hong Kong Paediatric Haematology & Oncology Study Group, Turkish Journal of Haematology (Abstract published in the conference proceedings for XXXth World Congress of the International Society of Haematology 2005, Istanbul, Turkey, 28 September - 2 October 2005. 22(suppl): 245.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

To K.W., Wong O.H., Li H.B., Chan S.F., Ma L., Cheung Y.L., Ko K.H., Chiang A.K.S. and Huang F., The effects of Bergapten in modulating dendritic cells (DC) functions for DC-based tumor vaccines, 10th Research Postgraduate Symposium, Hong Kong. December 3. 2005.

Wong O.H., Huang F. and Chiang A.K.S., Differential responses of cord and adult blood-derived dendritic cells to dying cells, Immunology (Cover Story). 2005, 116: 13-20.

Researcher : Chim S

List of Research Outputs

Chan S.Y. and Chim S., An infant became dialysis dependent after streptococcus pneumoniae induced haemolytic uraemic syndrome. A case report and literature review, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 54.

Chim S., Lee T.L., Chan S.Y. and Chan K.W., A case of tubulointerstitial nephritis and uveitis (TINU) syndrome treated with corticosteroid and mycophenolate mofetil, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 53.

Researcher : Chiu SSS

Project Title:	Streptococcus pneumoniae carriage in young children in Hong Kong
Investigator(s):	Chiu SSS, Ho PL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1999

Abstract:

To study the serotypes and the incidence of antibiotic resistant Streptococcus pneumoniae in young children in the community.

Project Title:	A population based study of hospitalization disease burden for respiratory viral infections in children
Investigator(s):	Chiu SSS, Lau YL, McGhee SM, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

To define the population based disease burden of influenzavirus and other respiratory viruses including RSV, adenovirus, parainfluenzae types I,II and III, rhinovirus, hMPV and the newly discovered SARS associated coronavirus in children hospitalized for acute respiratory infections; to define the role of influenza A in children hospitalized for febrile seizures and encephalopathy; to define the impact of these respiratory viruses on children with asthma exacerbations; to document the socio-economic impact of these respiratory viral infections on families with children hospitalized in Hong Kong; to perform phylogenetic analysis of hMPV in Asia.

Project Title:	A population based study of hospitalization disease burden for respiratory viral infections in children
Investigator(s):	Chiu SSS, Lau YL, McGhee SM, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

List of Research Outputs

Chiu S.S.S. and Lau Y.L., Review of the Varilrix varicella vaccine, Expert Rev Vaccines. 2005, 4: 629-643.

Ho P.L., Que T.L., Ng T.K., Chiu S.S.S., Yung R.W.H. and Tsang K.W.T., Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance, European Journal of Clinical Microbiology and Infectious Diseases. 2006, 25(5): 323-7.

Ho P.L., Chiu S.S.S., Cheung C.H., Lee R.A., Tsai T.F. and Lau Y.L., Invasive pneumococcal disease burden in Hong Kong children, The Pediatric Infectious Disease Journal. 2006, 25(5): 454-5.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong, Pediatrics. 2006, 117(6): e1156-1162.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-stratified seroperevalence of SARS-coronarvirus (SARS-CoV) among children in Hong Kong, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 44.

Researcher : Chong WP

List of Research Outputs

Chong W.P., Wong W.H.S., Chiu C.S. and Cheung Y.F., Aortic Root Dilation is Related to Aortic Stiffening in Children after Repair of Tetralogy of Fallot, Supplement to Circulation (Abstract from American Heart Association, Scientific sessions 2005, Dallas, Texas, USA), 13-16 November 2005. 112(17): 2288.

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Researcher : Chong WP

List of Research Outputs

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Researcher : Chow CB

List of Research Outputs

Henter J.I., Chow C.B., Leung C.W. and Lau Y.L., Cytotoxic therapy for severe avian influenza A (H5N1) infection, Lancet. 2006, 367(9513): 870-873.

Researcher : Chow IPS

List of Research Outputs

Chow I.P.S., Fielding R., Lam W.W.T., Byrne J. and Chan G.C.F., Association of colour with emotional state and sensation among Cantonese speaking children aged 3 - 8 years., Annual conference, Hong Kong Paediatrics Society, HKSAR, January 8th, . 2006.

Chow I.P.S., Fielding R., Lam W.W.T., Byrne J. and Chan G.C.F., Assoication of colour with emotional state and sensation among Cantonese speaking children aged 3-8 years, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 13.

Researcher : Chow PC

List of Research Outputs

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Chow P.C., Lun K.S. and Chau A.K.T., Pulmonary vascular complications in children with chronic liver diseases, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 57.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 56.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Researcher : Chung BHY

Project Title:	Identification of mutation in Chinese patients with marfan syndrome using denaturing high performance liquid chromatography (DHPLC) and study on its genotype-phenotype correlation
Investigator(s):	Chung BHY, Lau YL, Lun KS
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	02/2006

Abstract:

To apply and evaluate the use of DHPLC in detecting mutations in our local Chinese Marfan patients, with a view to establish genotype-phenotype correlation as well as to evaluate possibility of prenatal diagnosis in the future when mutation in a family is identified and prenatal diagnosis is sought.

List of Research Outputs

Chau A.K.T., Chung B.H.Y., Lun K.S., Cheung Y.F. and Yung T.C., Midterm Outcomes of Transcatheter Closure of Atrial Septal Defect Using the Amplatzer Septal Occluder in Children, Hong Kong Journal of Paediatrics (new series). 2005, 10: 251-256.

Chung B.H.Y., Ip P., Wong V.C.N., Lo J., Nicholls J.M. and Khong P.L., Acute fulminant SSPE with absent measels and PCR studies in cerebrospinal fluid, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Case Writer "Koo Lee Yan" for Integrated Block for PBL Group (Year 3), August - September 2005. 2005.

Chung B.H.Y., Lo I.F.M., Tong T.M.F., Chan W.K. and Lam S.T.S., Chromosome 15-derived marker chromosome: clinical outcomes and molecular findings in local patients, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 70-71.

Chung B.H.Y. and Wong V.C.N., Clinical Markers Useful in Enhancing Diagnostic Yield for children with Global Developmental Delay (GDD), 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 134.

Chung B.H.Y. and Wong V.C.N., Clinical markers that enhance etiologic yield in global developmental delay (GDD), 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 60.

Chung B.H.Y., Wat L.C.Y. and Wong V.C.N., Febrile Seizures in Southern Chinese Children: Incidence and Recurrence, Pediatric Neurology. 2006, 34(2): 121-126.

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Genetic thrombophilic risk factors in Chinese children with malignant illness, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 66.

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 25 novel and 2 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 62-63.

Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilia Does Not Increase Catheter Thrombosis in Chinese Children with malignancies, 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 82.

Chung B.H.Y., Wong V.C.N. and Wat L., Outcome of children with first febrile seizure – A local cohort study of 565 cases, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y. and Wong V.C.N., Pediatric Stroke in Southern Chinese, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Chung B.H.Y. and Wong V.C.N., Pediatric stroke in Southern Chinese, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal Muscular Atrophy (SMA) - Natural history and functional status in Hong Kong children, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006) Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal muscular atrophy (SMA) – Natural history and functional status in Hong Kong Children, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Study discussion: Catheter and thrombosis, HKPHOSG Annual Workshop 2006, 28 June 2006.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Automated method for the identification of conserved non-coding regions in hypoxic-ischaemic regulated genes in different species, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Fu W., Chung B.H.Y. and Smith D.K., Bioinformatic Pipeline for the Identification of Transciption Factor Binding Sites in Mouse and Human, Human Genome Meeting (HGM) 2006, Helsinki, Finland, 31 May - 3 June 2006. 59.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic piepline for the identification of transcription factor binding sites in mouse and human, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 93.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic pipeline for the identification of transcription factor binding sites in mouse and human, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 58.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis for putative transcription factor binding sites of a novel hypoxic-ischaemic regulated gene - HID-1, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 61.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis of putative promoter sequences of known and novel genes identified by hpoxic-ischaemic insult, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 118.

Fung C.W., Chung B.H.Y. and Wong V.C.N., Myasthenia gravis in Chinese children: Hong Kong perspective, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Ip P., Chung B.H.Y. and Wong V.C.N., Neuromuscular disorders in Chinese children: Hong Kong's experience in past 17 years, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 42.

Ip P., Chung B.H.Y., Wong V.C.N., Chan K.Y., Wong T., Sugnan V.K., Wu S.P., Liu K.T., Yeung W.L. and Ieong K.M., Subacute Sclerosing Panencephalitis (SSPE) – prevalence in Southern China, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Lun K.S., Lam S.T.S., Tong T.M.F., Chung B.H.Y., Li Y.H., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 88.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N. and Chung B.H.Y., Causes of global developmental delay (GDD) in Southern Chinese, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., Causes of global developmental delay (GDD) in southern Chinese, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 59.

Wong V.C.N. and Chung B.H.Y., Clinical markers useful in enhancing diagnostic yield for children with global developmental delay (GDD), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., Clinical markers useful in enhancing diagnostic yield for children with global developmental delay (GDD), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 60.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 133.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., Evaluating a Child with Partial Developmental Delay (ParDD), Global Developmental Delay (GDD) / Mental Retardation (MR): Clinical Expertise Based or Evidence-Based?, Current Pediatric Reviews. Bentham Science Publishers, 2006, 292): 143-153.

Wong V.C.N., Chung B.H.Y., Li Y.H., Goh W.H.S. and Lee S.L., Mutation of Gene in Spinal Muscular Atrophy Respiratory Distress Type I, Pediatric Neurology. 2006, 34(6): 474-477.

Wong V.C.N. and Chung B.H.Y., Pediatric Stroke in Southern Chinese, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 186.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W. and Goh W.H.S., Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation (SMARD1) in Chinese Boy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Wong V.C.N. and Chung B.H.Y., Survey of public awareness, understanding, and attitudes towards epilepsy in Hong Kong – A comparison of Chinese and Western culture, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., To identify causes and clinical markers for increasing diagnostic yield for children with global developmental delay (GDD), 10th International Child Neurology Congress, Montreal, Canada, 11-16 June 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S96.

Researcher : Fok SFS

List of Research Outputs

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Researcher : Fong SW

List of Research Outputs

Chan S.Y., Chan K.W., Yick L.W. and Fong S.W., Transgenic expression of testis specific protein Y-encoded-like 2 triggers developmental and behavioral changes, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S117.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Downregulation of Testis Specific Protein Y-encoded like 2 in neonatal heart development, 15^th International Soceity of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S54.

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Regulation of testis specific protein Y-encoded like 2, a member of nucleosome assembly proteins, in neonatal heart development, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 105.

Researcher : Fu W

List of Research Outputs

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Automated method for the identification of conserved non-coding regions in hypoxic-ischaemic regulated genes in different species, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Fu W., Chung B.H.Y. and Smith D.K., Bioinformatic Pipeline for the Identification of Transciption Factor Binding Sites in Mouse and Human, Human Genome Meeting (HGM) 2006, Helsinki, Finland, 31 May - 3 June 2006. 59.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic piepline for the identification of transcription factor binding sites in mouse and human, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 93.

Fu W., Chung B.H.Y., Smith D.K. and Cheung P.T., Bioinformatic pipeline for the identification of transcription factor binding sites in mouse and human, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 58.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis for putative transcription factor binding sites of a novel hypoxic-ischaemic regulated gene - HID-1, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 61.

Fu W., Chung B.H.Y., Chan K.W., Bhatia I., Smith D.K. and Cheung P.T., Sequence analysis of putative promoter sequences of known and novel genes identified by hpoxic-ischaemic insult, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 118.

Researcher : Fung CW

List of Research Outputs

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Fung C.W., Goh W.H.S. and Wong V.C.N., 2 patients with paroxysmal kinesigenic dyskinesia treatable with low dose carbamazepine, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Fung C.W. and Wong V.C.N., A child with recurrent ataxia and lactic acidosis due to pyruvate dehydrogenase deficiency (PDH), DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new Cause of Mental Retardation in a Young Chinese Girl: Congenital Disorder of Glycosylation, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 231.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new cause of mental retardation in a young Chinese girl: congenital disorder of glycosylation (CDG), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W. and Wong V.C.N., Children with mesial temporal sclerosis (MTS) in an epilepsy cohort - a different clinical spectrum?, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 Mutation: From Asymptomatic Carrier to Stiff Man Syndrome, 4^th World Congress for NeuroRehabilitation (Abstract in Neurorehabilitation & Neural Repair). 2006, 20(1): 231.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 mutation: from asymptomatic carrier to stiff man syndrome, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 mutation: from asymptomatic carrier to stiff man syndrome, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Chung B.H.Y. and Wong V.C.N., Myasthenia gravis in Chinese children: Hong Kong perspective, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Fung C.W. and Wong V.C.N., Program for Chinese Children with Developmental Disabilities - The Hong Kong Model, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 203.

Fung C.W. and Wong V.C.N., Program for Chinese Children with Developmental Disabilities - The Hong Kong Model, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Goh W.H.S. and Wong V.C.N., Suspected Leigh's disease: clinical spectrum in 2 cases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N., Lam C.W. and Fung C.W., An unusual phenotype in DYT1 dystonia: stiff man syndrome, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W. and Goh W.H.S., Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation (SMARD1) in Chinese Boy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Wong V.C.N., Lam C.W. and Fung C.W., Stiff Child Syndrome with Mutatin of DYT1 gene, Neurology. 2005, 65(9): 1465-1466.

Researcher : Goh WHS

List of Research Outputs

Fung C.W., Goh W.H.S. and Wong V.C.N., 2 patients with paroxysmal kinesigenic dyskinesia treatable with low dose carbamazepine, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new Cause of Mental Retardation in a Young Chinese Girl: Congenital Disorder of Glycosylation, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 231.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new cause of mental retardation in a young Chinese girl: congenital disorder of glycosylation (CDG), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Goh W.H.S. and Wong V.C.N., Suspected Leigh's disease: clinical spectrum in 2 cases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Goh W.H.S., Chan K.W. and Cheung P.T., A Chinese boy with progressing joint contractures, dystonia and psychomotor regression: A novel FUCA 1 mutation causing fucosidosis, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 56.

Leung C., Zhou S.Z., Wong V.C.N. and Goh W.H.S., A comparative study of the quality of life of children with epilepsy in Shanghai and Hong Kong, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Leung C., Zhou S.Z., Wong V.C.N. and Goh W.H.S., A comparative study of the quality of life of children with epilepsy in Shanghai and Hong Kong, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Leung C., Goh W.H.S., Khong P.L. and Wong V.C.N., Thalamic T2 hyperintensities and cognitive function in Chinese children with neurofibromatosis, Type I, DK 50th Anniversary Symposium on Paediatric Neuroloyg and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ng P.K., Hui Y., Lam B.C.C., Goh W.H.S. and Yeung C.Y., Feasibility of implementing a universal neonatal hearing screening program by dpoae detection at a university hospital in Hong Kong, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 41.

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N., Leung C., Zhou S.Z. and Goh W.H.S., A Comparative Study of the Quality of Life of Children with Epilepsy in Shanghai and Hong Kong, 4^th World Congress for NeuroRehabilitation, Hong Kong, February 12-16, 2006, Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 181.

Wong V.C.N., Chung B.H.Y., Li Y.H., Goh W.H.S. and Lee S.L., Mutation of Gene in Spinal Muscular Atrophy Respiratory Distress Type I, Pediatric Neurology. 2006, 34(6): 474-477.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W. and Goh W.H.S., Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation (SMARD1) in Chinese Boy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005.

Researcher : Ha SY

List of Research Outputs

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

Chan G.C.F., Shing M.M.K., Luk C.W., Lee A.C.W., Ling S.C., Li C.K. and Ha S.Y., Treatment Outcome of Childhood Neuroblastoma: the Hong Kong Experience, 4^th Congress of the International Society of Pediatric Oncology-Asia, Shanghai, PR China, 6-8 April 2006.

Chan V.N.Y., Ha S.Y., Au P., Lam C.C.K. and Chan T.K., A Chinese Family With Hemophilia B Leyden Due To T-->A Transition At Position +6 Of The FIX Gene, American Journal of Hematology. 2006, 81(4): 300-301.

Cheuk D.K.L., Lee T.L., Ha S.Y., Chan G.C.F., Lau Y.L. and Chiang A.K.S., Bone Marrow Transplantation for Hepatitis-associated Aplastic Anaemia: Case Reports and a Review of the Literature, Hong Kong Journal of Paediatrics (new series). 2006, 11: 32-38.

Cheuk D.K.L., Lee A.C.W., Chiang A.K.S., Ho M.H.K., Ha S.Y., Chan G.C.F. and Lau Y.L., Quality of life study on transfusion-dependent thalassemic patients in Hong Kong, 10^th International Conference on Thalassaemia & Haemoglobinopathies & 12^th International TIF Conference for Thalassaemia Patients and Parents, Dubai, United Arab Emirates, 7-10 January 2006. 148.

Ha S.Y., Chik K.W., Ling S.C., Lee A.C.W., Luk C.W., Lam C.W.K., Ng I.O.L. and Chan G.C.F., A randomized controlled study evaluating the safety and efficacy of deferiprone treatment in thalassemia major patients from Hong Kong, Hemoglobin. 2006, 30(2): 263-274.

Ha S.Y., As Chairperson for Session 16: Bone Marrow Transplantation, 12^th Hong Kong International Cancer Congress, HKU, 8-10 December 2005. 2005.

Ha S.Y., Chan G.C.F., Chiang A.K.S., Lee A.C.W., Lee T.L. and Lau Y.L., Bone Marrow Transplantation for Fanconi Anaemia Using a Fludarabine-based Preparative Regimen with CD34+ Cell Selection, Hong Kong Journal of Paediatrics (new series). 2006, 11: 39-44.

Ha S.Y., Leukaemia, histiocytosis, "Pediatric Oncology for Health Care Professionals" course organized by SPACE, HKU, 11 May 2006. 2006.

Ha S.Y., Overview of childhood cancer: epidemiology, etiology, diagnosis and advances in paediatric cancers, "Pediatric Oncology for Health Care Professionals" course organized by SPACE, HKU, 11 May 2006. 2006.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Li C.K., Chik K.W., Ha S.Y., Lee A.C., Yuen H.L., Ling S.C., Lee V., Chan G.C.F., Shing M.M., Chan L.C. and Ng M.H., Improved outcome of acute lymphoblastic leukaemia treated by delayed intensification in Hong Kong children: HKALL97 study, Hong Kong Medical Journal. 2006, 12(1): 33-9.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

Researcher : Ho JCS

List of Research Outputs

Ng D.K.K., Cheung J.M., Leung S.Y., Chow P.Y., Wong W.H.S., Chan C.H. and Ho J.C.S., Prevalence of Sleep Problems in Hong Kong Primary School Children - A Community-Based Telephone Survey, Chest. 2005, 128: 1315-1323.

Researcher : Ho MHK

List of Research Outputs

Cheuk D.K.L., Lee A.C.W., Chiang A.K.S., Ho M.H.K., Ha S.Y., Chan G.C.F. and Lau Y.L., Quality of life study on transfusion-dependent thalassemic patients in Hong Kong, 10^th International Conference on Thalassaemia & Haemoglobinopathies & 12^th International TIF Conference for Thalassaemia Patients and Parents, Dubai, United Arab Emirates, 7-10 January 2006. 148.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 56.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Ho M.H.K., Heine R.G., Wong W.H.S. and Hill D.J., Diagnostic accuracy of skin prick testing in children with tree nut allergy, Journal of Allergy Clinical Immunology. 2006, 117(6): 1506-1508.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Ho M.H.K. and Hill D.J., White button mushroom food hypersensitivity in a child, Journal of Paediatrics and Child Health. 2006, 42: 555-556.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Environmental mercury exposure in children - South China's experience, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Wong V.C.N., Ho M.H.K., Lee J. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A Case-Control Study, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 171.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 45.

Ng Y.M., Sung R.Y.T., So L.Y., Fong N.C., Ho M.H.K., Cheng Y.W., Lee S.H., Mak W.C., Wong D.M.L., Yam M.C., Kwok K.L. and Chiu W.K., Kawasaki disease in Hong Kong, 1994 to 2000, Hong Kong Medical Journal. 2005, 11(5): 331-335.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

Sung R.Y.T., Ng Y.M., Choi K.C., Mok G.C.F., Cheng Y.W. and Ho M.H.K., Lack of Associaton of Cervical Lymphadenopathy and Coronary Artery Complications in Kawasaki Disease, The Pediatric Infectious Disease Journal. 2006, 25(6): 521-525.

Researcher : Hui L

List of Research Outputs

Hui L., Chau A.K.T., Leung M.P. and Cheung Y.F., Dobutamine stress echocardiographic assessment of left ventricular function long after intervention for coronary artery fistula, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(SupplA): 243A.

Researcher : Hui LH

List of Research Outputs

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal Muscular Atrophy (SMA) - Natural history and functional status in Hong Kong children, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006) Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal muscular atrophy (SMA) – Natural history and functional status in Hong Kong Children, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 133.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Researcher : Ip EWK

List of Research Outputs

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Researcher : Ip P

List of Research Outputs

Chung B.H.Y., Ip P., Wong V.C.N., Lo J., Nicholls J.M. and Khong P.L., Acute fulminant SSPE with absent measels and PCR studies in cerebrospinal fluid, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal Muscular Atrophy (SMA) - Natural history and functional status in Hong Kong children, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006) Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal muscular atrophy (SMA) – Natural history and functional status in Hong Kong Children, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Ip P., Goh W.H.S., Chan K.W. and Cheung P.T., A Chinese boy with progressing joint contractures, dystonia and psychomotor regression: A novel FUCA 1 mutation causing fucosidosis, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 56.

Ip P., Attention Deficit - Hyperactivity Disorder and Learning Disabilities - Are They Related? What Is the Treatment?, 4^th World Congress for NeuroRehabilitation (Abstract in Neurorehabilitation & Neural Repair). 2006, 20(1): 170.

Ip P., Attention-deficit / hyperactivity disorder and learning disabilities, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 33.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Environmental mercury exposure in children - South China's experience, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Wong V.C.N., Ho M.H.K., Lee J. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A Case-Control Study, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 171.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Chung B.H.Y. and Wong V.C.N., Neuromuscular disorders in Chinese children: Hong Kong's experience in past 17 years, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 42.

Ip P., Knight R., Dokal I., Manzur A. and Muntoni F., Peripheral Neuropathy - A Novel Finding in Dyskeratosis Congenita, 4^th World Congress for NeuroRehabilitation (Abstract in Neurorehabilitation & Neural Repair). 2006, 20(1): 170.

Ip P., Knight R., Dokal I., Manzur A.Y. and Muntoni F., Peripheral neuropathy - A novel finding in dyskeratosis congenita, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 43.

Ip P., Chung B.H.Y., Wong V.C.N., Chan K.Y., Wong T., Sugnan V.K., Wu S.P., Liu K.T., Yeung W.L. and Ieong K.M., Subacute Sclerosing Panencephalitis (SSPE) – prevalence in Southern China, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Researcher : Ip WKE

List of Research Outputs

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Researcher : Jiang L

List of Research Outputs

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Researcher : Karlberg JPE

Project Title:	Long-term health consequences of insults in early life
Investigator(s):	Karlberg JPE, Low LCK
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	11/1995

Abstract:

To understand the impact of early insults for health in adult-hood.

List of Research Outputs

Researcher : Kwan EYW

List of Research Outputs

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Researcher : Lam BCC

List of Research Outputs

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C. and Lam B.C.C., Regional white matter anisotropy and general intelligence in preterm born children: a voxelwise analysis, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Lam B.C.C., Tsao Y.C. and Hui Y., Clinical Practice Guideline on the Diagnosis and Management of Acute Otitis Media, Hong Kong Journal of Paediatrics. 2006, 11(1): 76-83.

Lam B.C.C., Newborn hearing screening in Hong Kong, Hong Kong Medical Journal. 2006, 12(3): 212-218.

Lam B.C.C., Survey Findings and Insight on Workplace Violence, 1^st International Conference of Asia Pacific Society for Healthcare Quality, 5-7 January 2006. 17.

Lam B.C.C., Universal vs high risk screening - experience in Hong Kong, Proceedings of the Advances in Deafness Management, Hong Kong, 8-9 October 2005. 15-17.

Lam B.C.C., 香港新生兒聽力篩查的現狀, 中華兒科雜誌, 2006, 44(1): 64-67.

Ng P.K., Hui Y., Lam B.C.C., Goh W.H.S. and Yeung C.Y., Feasibility of implementing a universal neonatal hearing screening program by dpoae detection at a university hospital in Hong Kong, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 41.

Ting J.Y., Lam B.C.C., Ngai C.S.W., Leung W.C. and Chau K.L., Splenic rupture in a premature neonate, Hong Kong Medical Journal. 2006, 12(1): 68-70.

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005.

Researcher : Lam TW

List of Research Outputs

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Researcher : Lau ASY

Project Title:	Mechanism of SARS-coronavirus pathogenesis - identification of viral genes implicated in immune dysregulation
Investigator(s):	Lau ASY, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate the pathogenesis of SARS-Coronavirus-induced pulmonary injury and multi-organ dysfunctions in humans: (a) to identify the viral determinants of proinflammatory cytokine induction: candidate envelope genes to be examined include Spike (S), Envelope (E) and Membrane (M); (b) to investigate the signaling pathways including kinases and transcription factors involved in the cytokine induction.

Project Title:	A role for apoptogenic gene PKR in regulating TNF and cytokine expression in Avian influenza H5N1 infections
Investigator(s):	Lau ASY, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2003

Abstract:

To investigate whether H5N1/97 is a potent inducer of specific signaling kinases, compared to H1N1 or H3N2, leading to enhanced cytotoxicity in the host cell; to investigate whether H5N1/97 induction of TNF-[alpha] and related proinflammatory cytokines is dependent on the expression of these signaling kinases; the mechanism of H5N1/97-induced TNF-[alpha] and related cytokine expression; to identify transcription factors (TF) operative in H5N1-induced and kinase-mediated pathways; the role of these signaling kinases in H5N1/97-induced cytotoxicity: to identify kinase-regulated downstream pathways and induction of apoptogenic genes.

Project Title:	A role for apoptogenic gene PKR in regulating TNF and cytokine expression in Avian influenza H5N1 infections
Investigator(s):	Lau ASY, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	10/2003

Abstract:

N/A

Project Title:	Immune dysregulation in HIV infection - mechanism of mycobacterial pathogenesis
Investigator(s):	Lau ASY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	Immune dysregulation in HIV infection - mechanism of mycobacterial pathogenesis
Investigator(s):	Lau ASY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To confirm the role of HIV tat on monocytic cells in TH2 cytokine induction and TH1 reponse suppression; to identify the signaling pathways and transcription factors operative in Tat activation of IL-10 promoter; to investigate the effects of BCG or mycobacterial cell wall submits on IL-10 induction; to examine whether Tat interacts with TLR-associated kinases and factors directly or via PKR; to delineate whether exogenous IFN-[gamma] and other TH1 cytokines can counteract the effects of Tat and MTB in IL-10 induction.

Project Title:	Immunotherapy of mycobacterial infections: a cell and molecular model
Investigator(s):	Lau ASY, Lee DCW
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2005

Abstract:

To examine the profile of cytokine expression including proinflammatory cytokines and anti-inflammatory cytokines in BCG and mycobacterial cell wall subunits-treated cells; to confirm the role of PKR and related kinases in signaling pathways operative in the BCG- and cell wall subunit-induced cytokine expression; to examine the role of IL-10 in inhibition of IFN signaling and macrophage functions; to examine whether IL-10 induces the expression of SOCS to inhibit IFN-gamma signaling; to delineate whether exogenous IFN-gamma and other TH1 cytokines can modulate and reverse the effects of BCG and IL-10 in SOCS induction and restore the effects of IFN-gamma macrophage function.

Project Title:	Cytokine Dysregulation and Virus-Induced Cell Death in Avian Influenza Virus Infections
Investigator(s):	Lau ASY, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Abstract:

Objectives: In this project, we will use H9N2 as prototypes to examine the cellular effects of TNF and IFN induction by avian influenza viruses. We will delineate whether there is differential induction of cytotoxicity by the avian viruses from the human ones. We will also examine the consequences of simultaneous induction of TNF and IFN on cell survival and expression of apoptotic genes. Our Specific Aims are 1) We will delineate whether there is a differential induction of cytotoxicity by the avian viruses (H9N2) compared to the human ones (H1N1 or H3N2). 2) We will examine the consequences of simultaneous induction of TNF and IFN on cell survival and expression of apoptotic genes. Background Influenza A virus infects a wide range of species, including poultry, swine, horses, seals and humans. Of the 15 hemagglutinins (HA) subtypes of influenza A, only H1, H2 and H3 had been known to cause significant morbidity and mortality in humans (1-3). The 1997 outbreak of avian influenza H5N1/97 in Hong Kong was the first documented cases of primary pneumonia rapidly progressing to adult respiratory distress syndrome and multiple organ dysfunctions in humans. In light of the high mortality of H5N1/97 infection, it would be desirable to understand the pathogenesis in order to enhance the development of novel therapy. Influenza A viruses are known to replicate in epithelial cells and leukocytes, resulting in induction of cytokines(4). During influenza virus infection, a multiple array of cytokines, including chemokines (Rantes, MIP-1), and interferons (IFN-α and –β), is induced (5,6). The biological actions of IFNs are mediated by multiple pathways resulting in mRNA degradation by ribonuclease L and inhibition of translation by a dsRNA-activated kinase, PKR. PKR is inducible by IFN, TNF-α, and dsRNA [viral RNA analogue] (7,8). We have previously shown that PKR mediates the cytotoxicity of TNF-α in cells of diverse tissue origins including fibroblasts and monocytes (9). It has been proposed that PKR serves as a common pattern-recognition molecule responsible for mediating these virus-induced antiviral effects (8-11). We previously demonstrated PKR serves multiple roles in the cell including the mediation of TNF-induced cytotoxicity, and induction of apoptotic gene p53 and IFN expression (9, 12-16). The signal transduction role of PKR is further confirmed by its effects on the induction of Fas and NF-kB, following TNF-α or endotoxin treatment. TNF-α is a potent, cytotoxic molecule induced in response to invasion by infectious pathogens or cancer cells. Elevated levels of TNF-α in the serum have been correlated to and predictive of morbidity and mortality in patients with meningococcemia. To unravel the pathogenesis of fulminant H5N1/97 disease in humans, we have developed a H5N1/97-blood macrophage (BMac) model to examine the interactions of H5N1/97-encoded genes and cellular factors which may result in immune dysregulation (17: Peiris as PI and Lau as co-I). Using our model, we have previously demonstrated that H5N1/97 induced dramatically higher levels of cytokine expression when compared to those elicited by “conventional” human H1N1 or H3N2 viruses (17). TNF-α protein levels in H5N1/97-infected macrophage culture supernatants were comparable to those induced by stimulation with E. coli endotoxin, and much higher than those in H1N1 or H3N2 infections (17). Recently, we further demonstrated that the TNF induction and its cytotoxicity are mediated, at least in part, by mitogen-activated protein (MAP) kinases including p38 and ERK (18: J Virol 2005, accepted May 2005, Lau as PI). Induction of proinflammatory cytokines is a major defense mechanism of the host to mobilize the immune system and to combat the invading pathogen. We hypothesize the high mortality associated with H5N1/97 infections may be due to an uncontrolled induction of IFN and TNF, consequent to virus interactions with cellular signaling pathways, leading to dysregulated immune response and differential effects on cell death.

List of Research Outputs

Chan C., Chan W.K., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium extract can enhance maturation of human monocyte-derived dendritic cells, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 577.

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-Stranded RNA-Activated Protein Kinase PKR in Bacillus Calmette Guerin (BCG)-Induced Cell Death, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 289.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-stranded RNA-activated Protein Kinase PKR in Bacillus Calmétte Guerin (BCG)-induced Cell Death., In: Benny K.W. Cheung, Davy C.W. Lee and Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Cheung B.K.W. and Lau A.S.Y., Signaling pathways in mycobacterial infection: Involvement of Toll-like receptors., In: BKW Cheung, and AS Lau., 10th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong.. 2005.

Lau A.S.Y., Immunological effects of TCM and herbal extracts, Visit to manufacturing and research facilities of PuraPharm International (HK) Ltd., Nanning, PR China, 26-28 April 2006. 2006.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 211.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Resersch (Program & Abstracts from the 2005 Annual meeting of International Society for Interferon and cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10): 211.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of H5N1 Avian Influenza Virus Induced TNF-alpha dysregulation and a Delay in Apoptosis in Primary Blood Macrophages, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 100.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis. * Recipient of 2nd Prize Young Investigator Award., In: Davy C.W. Lee, Chris K.P. Mok, Chung-Yan Cheung, Anna H.Y. Law, Malik Peiris and Allan S.Y. Lau., 7th World Congress on Inflammation, 20 - 24 August 2005 in Melbourne, Australia.. 2005.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis, Inflammation Research (Official Journal of The International Societies, The European Histamine Research Society), 23 August 2005. 54: S181.

Lee D.C.W., Cheung C.Y., Law H.Y., Mok K.P., Peiris J.S.M. and Lau A.S.Y., p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Reponse to Avian Influenza Virus H5N1, Journal of Virology. 2005, 79(16): 10147-10154.

Lin S.S., Chua D.T.T., Lee C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression., In: Belinda S.S. Lin, Daniel T.T. Chua, Davy C.W. Lee, Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Lin S.S., Lee D.C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) suppl: 218.

Ng K.M., Che C.M., Wo S.K., Tam P.K.H. and Lau A.S.Y., Analytical Application of Acetate Anion in Negative Electrospray Ionization Mass Spectrometry for the Analysis of Triterpenoid Saponins - Ginsenosides , Rapid Communications in Mass Spectrometry. John Wiley and Sons, 2006, 20: 1545 - 1550.

Yim H.C.H., Li C.B. and Lau A.S.Y., Mechanism of HIV-Regulated Toll-like receptors expression., In: H.C.H. Yim, J.C.B. Li, A.S.Y. Lau., 10th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong. December 2005.

Researcher : Lau KS

List of Research Outputs

Lau K.S., Hung C.N., Shum S., Ngai C.F., Ho S.L., Ng K.S. and Wong V.C.N., Identifying prenatal, perinatal and environmental risk factors to autism spectrum disorder: case-control study, 10th Research Postgraduate Symposium. 2005.

Wong V.C.N., Lau K.S., Hung C.N., Shum T., Ngai C.F., Ho S.L. and Ng K.S., Identifying prenatal, perinatal and environmental risk factors for autism spectrum disorder (ASD): a case-control study, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S168.

Researcher : Lau YL

Project Title:	A community-based educational program on thalassaemias to enhance awareness with the aim to reduce burden of thalassaemia related health problems in Hong Kong
Investigator(s):	Lau YL, Ha SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health Promotion Projects
Start Date:	09/1997

Abstract:

To enhance the awareness of the community regarding thalassaemias; to counsel, screen and/or refer clinets who come forward to the Unit after the educational sessions; to decrease the disease burden of thalassaemias in Hong Kong as well as to serve as a possible model for southern China.

Project Title:	Comparison of process upgrade varicella vaccine (Puvv) with VARILRIX-TM
Investigator(s):	Lau YL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1999

Abstract:

To evaluate and provide information on the safety, tolerability, and immunogenicity of the Process Upgrade Varicella Vaccine (PUVV) at ~16,000 or ~50,000 PFU/0.5ml compared to VARILRIX ( estimated at a release dosage of ~50,000PFU/dose) when they are concomitantly with MMRII at separate injection sites.

Project Title:	Seroepidemiological prevalence survey of SARS-associated coronavirus antibody in children residing in Amoy Garden compared to a control group in southern district
Investigator(s):	Lau YL, Peiris JSM, Chiu SSS, Lam TH
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	05/2004

Abstract:

To define the seropositive rate of SARS-associated coronavirus (CV) infection among children who are household contacts or community contacts of SARS cases; to ascertain the full clinical spectrum of SARS-associated CV infection among chldren in Amoy Garden.

Project Title:	Interferon-gamma gene polymorphism in systemic lupus erythematosus and rheumatoid arthritis
Investigator(s):	Lau YL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To study the association of IFN-γ gene polymorphism (+874 A/T) with SLE and RA (case-control study); to investigate the association of this polymorphism with the clinical manifestation in patients with SLE and RA.

Project Title:	Joint Course on Molecular Medicine under the Joint Centre for Advanced Study
Investigator(s):	Lau YL
Department:	Medical Faculty
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/2005

Abstract:

To carry out a joint course on molecular medicine under the Joint Centre for Advanced Study.

Project Title:	The role of dentritic cells in SARS coronavirus infection
Investigator(s):	Lau YL, Peiris JSM, Law HKW
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	08/2005

Abstract:

Despite the SARS epidemic being controlled by case isolation, neither an effective treatment nor an efficacious vaccine is available. Our study will shed lights on the pathogenesis and the immune evasion of SARS-CoV and the knowledge gained may facilitate the development of new treatment protocols and vaccines for SARS.

Project Title:	Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS
Investigator(s):	Lau YL, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2005

Abstract:

To test the association of single nucleotide polymorphisms (SNPs) and microsatellites of 6 cytokine and chemokine genes, i.e. interferon-gamma (IFN-gamma), interluekin-12 (IL-12), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and interferon gamma-induced protein-10 (IP-10) with susceptibility to SARS; To test the association of these SNPs and microsatellites with mortality from SARS.

Project Title:	Immune response of cord blood macrophages and dendritic cells to the 1997 and 2004 strains of avian influenza viruses
Investigator(s):	Lau YL, Peiris JSM
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2005

Abstract:

(1) To determine the host response against human/avian viruses infection. In particular, we will focus on: host immune responses; mechanism of lymphopenia;evolution of H5N1; (2) to campare the cytokine/chemokine expression in antigen presenting cell infected by different influenza viruses; (3) to determine the expression of death receptor ligands in influenza infected APCs and subsequent effect on T cell priming and polarisation.

Project Title:	p21 gene polymorphism with systemic lupus erythematosus and rheumatoid arthritis
Investigator(s):	Lau YL, Lau WCS
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Systemic lupus erythematosus (SLE ) is a complex, multifactorial autoimmune disease that is characterized by the production of various autoantibodies. Dysregulated T cell-dependent induction of autoreactive B cells is considered to play a critical role in the development of SLE (1). The etiology and pathogenesis of SLE remain unclear, but the increased concordance rate in monozygotic twins, familial aggregation and high heritability suggested that the genetic factor is involved in the development of SLE (2-4). Cyclin-dependent kinase inhibitor 1A (also known as p21, WAF1 or CDKN1A) is a negative regulator of cyclin dependent kinases (CDKs) (5). The p21 protein encodes a 21 kDa cell cycle regulatory protein that forms quaternary complexes with the entire cyclin/CDK holoenzyme and acts as pancyclin inhibitors (6). It interacts with CDK2, CDK3, CDK4 and CDK6, thereby inhibiting the progression from the G1 to the S phase of the cell cycle (7-9). It can also bind to the replication factor proliferating cell nuclear antigen (PCNA) and inhibit DNA replication (10). The p21 gene contains the p53 binding site that is localized at 2.4 kb upstream from the translational start site and expression of p21 gene was found to be inducible by wild-type p53 gene expression (11). Moreover, several growth factors and cytokines, including interferon (IFN)-α and -γ, can modify p21 expression (12,13). As p21 is an important molecule in mediating cell cycle arrest, loss of function in p21 may favor cell proliferation. Mutations in the p21 gene have been reported to associate with development of various cancers (14-17). And cells lacking p21 gene are defective in DNA repair, which might induce impaired regulation in cell proliferation (18). Inactivating mutations of p21 lead to overexpression and hyperactivation of low-avidity, autoreactive T cells that are found in abundance in the peripheral lymphoid organs of normal individuals (19). These findings suggested that dysregulated p21 gene expression might contribute to defective cell cycle regulation and therefore lead to excessive cell proliferation and activation. The human p21 gene maps on chromosome 6p21.2 (11), which is a susceptibility region for SLE (20,21). A significant reduction in p21 gene expression is found in SLE patients as compared to controls (22). A lower expression in SLE patients is detected at various points from the G1 to G2/M phase through the S phase when compared with controls (22). Therefore, malfunction of p21 protein may contribute to the pathogenesis of systemic autoimmunity through a variety of primary or secondary mechanisms. Indeed, the p21-/- female mice with 129/Sv x C57BL/6 mixed backgrounds show development of severe lupus-like diseases followed by early mortality, high levels of anti-dsDNA antibodies and kidney immune complex deposits (23). However, the p21-/- lupus-prone BXSB mice show inhibition for the development of systemic autoimmunity (24). The p21-/- BXSB lupus-prone mice show enhancement of the Fas/FasL-mediated activation-induced T cell death and therefore promote the apoptosis of the accumulated autoreactive T and B cells, which inhibit spontaneous systemic autoimmunity (24). Although the above findings showed conflicting results for p21 deficiency, they suggested p21 gene is involved in the pathogenesis of SLE. Similar to SLE, rheumatoid arthritis (RA) is also a complex autoimmune diseases that involves genetic factors. Although disease pathogenesis remains unclear, we have previously identified the mannose binding lectin (MBL) gene as susceptibility gene in both SLE and RA (25-27) and recently, we have demonstrated that the low producing genotype of IL-10 promoter is associated with disease susceptibility and serositis in Hong Kong Chinese patients with SLE (28). The identification of susceptibility allele in SLE and RA by case-control study offers the potential for early prediction of risk of disease progression. This should also provide an approach to select the most appropriate candidate genes for intervention with new biological agents which may prevent or arrest disease progression in those at highest risk. References: Please refer to attachment [05-CRCG-SLE-References.doc]

Project Title:	Immune response of cord blood macrophages and dendritic cells to the 1997 and 2004 strains of avian influenza viruses
Investigator(s):	Lau YL
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2005

Abstract:

N/A

List of Research Outputs

Chan C., Chan W.K., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium extract can enhance maturation of human monocyte-derived dendritic cells, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 577.

Chan G.C.F., Mo F.Y., Yip H.K., Li J., Law H.K.W. and Lau Y.L., Bacterial Endotoxin LPS but Not LTA Can Enhance Osteogenic Differentiation of Human Mesenchymal Stell Cells, Blood. 2005, 106(11): 138b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Immunopotent Polysaccharides of Different Sources Selectively Activate Human Dendritic Cells, Blood. 2005, 106(11): 49b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Lingzhi polysaccharides can activate human dendritic cells maturation, 2005年全國小兒血液/腫瘤學術會議, Hangzhou, PR China, 9-13 October 2005, Hangzhou, PR China, 2005, 84-85.

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Chan S.S.C., Lam T.H., Salili F., Leung G.M., Wong C.N., Botelho R.J., Lo S.L. and Lau Y.L., A randomized controlled trial of an individualized motivational intervention on smoking cessation for parents of sick children: a pilot study, In: Chan SS, Lam TH, Salili F, Leung GM, Wong DC, Botelho RJ, Lo SL, Lau YL, Applied Nursing Research. 2005, 18: 178-181.

Chan S.S.C., Leung D.Y.K., Wong E.M.Y., Tiwari A.F.Y., Wong C.N., Lo S.L. and Lau Y.L., Balancing infection control practices and family-centred care in a cohort of paediatric suspected severe acute respiratory syndrome patients in Hong Kong, Journal of Paediatrics and Child Health. Blackwell Publishing Ltd, 2006, 42 (1-2): 20-27.

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Cheuk D.K.L., Lee T.L., Ha S.Y., Chan G.C.F., Lau Y.L. and Chiang A.K.S., Bone Marrow Transplantation for Hepatitis-associated Aplastic Anaemia: Case Reports and a Review of the Literature, Hong Kong Journal of Paediatrics (new series). 2006, 11: 32-38.

Cheuk D.K.L., Lee A.C.W., Chiang A.K.S., Ho M.H.K., Ha S.Y., Chan G.C.F. and Lau Y.L., Quality of life study on transfusion-dependent thalassemic patients in Hong Kong, 10^th International Conference on Thalassaemia & Haemoglobinopathies & 12^th International TIF Conference for Thalassaemia Patients and Parents, Dubai, United Arab Emirates, 7-10 January 2006. 148.

Cheung B.K.W., Lee D.C.W., Li C.B., Lau Y.L. and Lau Y.L., A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression, Journal of Immunology. 2005, 175(11): 7218-7225.

Chiu S.S.S. and Lau Y.L., Review of the Varilrix varicella vaccine, Expert Rev Vaccines. 2005, 4: 629-643.

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 56.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 25 novel and 2 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 62-63.

Ha S.Y., Chan G.C.F., Chiang A.K.S., Lee A.C.W., Lee T.L. and Lau Y.L., Bone Marrow Transplantation for Fanconi Anaemia Using a Fludarabine-based Preparative Regimen with CD34+ Cell Selection, Hong Kong Journal of Paediatrics (new series). 2006, 11: 39-44.

Henter J.I., Chow C.B., Leung C.W. and Lau Y.L., Cytotoxic therapy for severe avian influenza A (H5N1) infection, Lancet. 2006, 367(9513): 870-873.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Ho P.L., Chiu S.S.S., Cheung C.H., Lee R.A., Tsai T.F. and Lau Y.L., Invasive pneumococcal disease burden in Hong Kong children, The Pediatric Infectious Disease Journal. 2006, 25(5): 454-5.

Kwok J.S.Y., Hui K.H., Lee T.L., Wong W.H.S., Lau Y.L., Wong W.S., Kim D.L. and Jones B.M., Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population, Scandinavian Journal of Rheumatology. 2005, 34(5): 359-366.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Tse H., Tsoi H.W., Cheng V.C.C., Lee P., Tang S.F., Cheung C.H.Y., Lee R.A., So L.Y., Lau Y.L., Chan K.H. and Yuen K.Y., Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong, Journal of Clinical Microbiology. 2006, 44(6): 2063-2071.

Lau Y.L., Advances in the treatment of juvenile arthritis, Asia Autoimmunity Forum 2006, Hong Kong, 4 March 2006.

Lau Y.L., Approach to a child with recurrent infections - Is it primary immunodeficiencies?, 順德婦幼保健院, 順德, 中國, 1-2 April 2006, 2006.

Lau Y.L., Approach to a child with recurrent infections - Is it primary immunodeficiency?, National Taiwan University Hospital, Taipei, Taiwan, 9-11 June 2006. 2006.

Lau Y.L., Approach to a child with recurrent infections Is it primary immunodeficiency?, University of Malaya, Kuala Lumpur, 5-15 March 2006. 2006.

Lau Y.L., Chairman, In: Lau YL, Scientific Committee on AIDS and STI. 2005.

Lau Y.L., Genetic susceptibility and immune evasion in SARS and avian influenza, 109^th Annual Meeting, Japan Pediatric Society, Kanazawa, Japan, 21 April 2006.

Lau Y.L., Immune evasion and genetic susceptibility in SARS, Institute of Chile Health, Alder Hey Children's Hospital, Liverpool, UK, 19 October 2005. 2005.

Lau Y.L., Immune evasion in SARS and Avian influenza, In: Lau YL, 小兒免疫臨床與研究進展專題研討會, 2005.

Lau Y.L., Innate Immunity in SARS: Genetics and Developmental Immunology, In: Lau YL, World Society for Pediatric Infectious Diseases. 2005.

Lau Y.L., Ng M.W., Peiris J.S.M., Pak S., Yung W.H., Chow Y., Au K.L., Chan Y.T., Lim W., Bonnevie-Nielsen V. and Field L.L., Innate immune response genes polymorphisms in SARS, 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 50.

Lau Y.L., Is monogenic disease monogenic?, University of Malaya, Kuala Lumpur, 5-15 March 2006. 2006.

Lau Y.L., Mannose binding lectin in SARS, HBV and tuberculosis, 1^st International Symposium on Primary Immunodeficiency and Related Disorders, Beijing, PRC, 10-12 May 2006.

Lau Y.L., Member, In: Lau YL, Ad Hoc Working Group on the UGC Mission Statement (MSAG), University Grants Committee. 2005.

Lau Y.L., Network of PID Diagnostic Service in China, 1^st International Symposium on Primary Immunodeficiency and Related Disorders, Beijing, PRC, 10-12 May 2006.

Lau Y.L. and Peiris J.S.M., Pathogenesis of severe acute respiratory syndrome, In: Lau YL, Peiris JS, Current Opinion in Immunology. 2005, 17(4): 404-410.

Lau Y.L., SARS and Avian Flu: What have we learnt?, 1^st Annual Scientific Meeting & Inauguration Ceremony of Macau Pediatric Society, Macau, PRC, 20-21 May 2006. 2006.

Lau Y.L., SARS and Avian Influenza - what have we Learnt?, University of Malaya, Kuala Lumpur, 5-15 March 2006. 2006.

Lau Y.L., The role of MBL in SARS and HBV infection - The Hong Kong connection, Festschrift for Prof M Turner, Institute of Child Health, London, UK, 18 October 2005. 2005.

Lau Y.L., The role of mannose binding lectin in Tuberculosis, SARS and HBV infection, University of Toyama, Toyama, Japan, 18 April 2006. 2006.

Lau Y.L., Update on juvenile idiopathic arthritis, University of Malaya, Kuala Lumpur, 5-15 March 2006. 2006.

Lau Y.L., What do we need to know to support the use of Rotavirus vaccine in Asia?, 2006 台灣小兒消化醫學會, Taipei, Taiwan, 9-11 June 2006, Taipei, Taiwan, 2006.

Lau Y.L., What do we need to know to support the use of Rotavirus vaccine in Asia?, Mini-Forum on "A new human strain vaccine (RIX 4414) preventing rotavirus infection and diarrhoeal disease", Taipei, Taiwan, 9-11 June 2006. 2006.

Lau Y.L., 原發性免疫缺陷病, 2006 中國兒科中青年學者論壇, Shanghai, PRC, 15 May 2006, 2006.

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 45.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong, Pediatrics. 2006, 117(6): e1156-1162.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-stratified seroperevalence of SARS-coronarvirus (SARS-CoV) among children in Hong Kong, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 44.

Lee S.L., Wong W.H.S. and Lau Y.L., Association between air pollution and asthma admission among children in Hong Kong, Clinical and Experimental Allergy. Blackwell Publishing, 2006, 36: 1138-1146.

Li J., Law H.K.W., Lau Y.L. and Chan G.C.F., Different in vitro effects of chemotherapeutic agents on human mesenchymal stem cells, The Proceedings of The 10^th Congress of Bone Marrow Transplant Centre, The First Affiliated Hospital of Zhejiang University, Hangzhou, China, 13-16 October 2005. 61.

Lo A.K.F., Lo K.W., Tsao G.S.W., Wong H.L., Hui J.W.Y., To K.F., Hayward S.D., Chui Y.L., Lau Y.L., Takada K. and Huang D.P., Epstein-Barr Virus Infection Alters Cellular Signal Cascades in Human Nasopharyngeal Epithelial Cells, Neoplasia. 2006, 8(3): 173-180.

Lu Y.B., Kobayashi K., Ushikai M., Tabata A., Kawabe K., Taura S., Yang Y., Chiang S.H., Hsiao K.J., Lau Y.L., Tsui L.C. and Lee D.H., Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency, In: Lu YB, Kobayashi K, Ushikai M, Tabata A, Iijima M, Li MX, Lei L, Kawabe K, Taura S, Yang Y, Liu TT, Chiang SH, Hsiao KJ, Lau YL, Tsui LC, Lee DH, Saheki T, Journal of Human Genetics. 2005, 50: 338-346.

Lun K.S., Lam S.T.S., Tong T.M.F., Chung B.H.Y., Li Y.H., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 88.

Ng M.W., Lau W.C.S., Chan D.T.M., Wong W.H.S. and Lau Y.L., Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese., Rheumatology. 2005, 44(11): 1456-1457.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

Zhang M., Ko K.H., Lam Q.L.K., Srivastava G., Zheng B., Lau Y.L. and Lu L., Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis, International Immunology. 2005, 17(8): 1081-1092.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses, 6^th Guangdong - Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006 (2^nd Prize in Poster Presentation). 2006, 38.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Functional Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Production by Avian Influenza Virus-Infected Macrophages, The Journal of Infectious Diseases. 2006, 193(7): 945-953.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Impairment of T lymphocytes activation in avian influenza: an in vitro study, 6th Guangdong – Hong Kong Paediatric Exchnage Meeting. China, 2006, 39.

Zhou J. and Lau Y.L., 變種病毒人傳人之謎, 流感, 禽流感真貌, Hong Kong, 明窗, 2006, Chapter 4: 29-38.

Researcher : Law HKW

List of Research Outputs

Chan C., Chan W.K., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium extract can enhance maturation of human monocyte-derived dendritic cells, 37^th Annual Conference of The International Society of Paediatric Oncology SIOP 2005, Vancouver, Canada, 21-24 September 2005 (Abstract in Pediatric Blood & Cancer). 2005, 45(4): 577.

Chan G.C.F., Mo F.Y., Yip H.K., Li J., Law H.K.W. and Lau Y.L., Bacterial Endotoxin LPS but Not LTA Can Enhance Osteogenic Differentiation of Human Mesenchymal Stell Cells, Blood. 2005, 106(11): 138b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Immunopotent Polysaccharides of Different Sources Selectively Activate Human Dendritic Cells, Blood. 2005, 106(11): 49b.

Chan G.C.F., Chan W.K., Law H.K.W., Lin Z.B. and Lau Y.L., Lingzhi polysaccharides can activate human dendritic cells maturation, 2005年全國小兒血液/腫瘤學術會議, Hangzhou, PR China, 9-13 October 2005, Hangzhou, PR China, 2005, 84-85.

Chan W.K., Lam T.W., Law H.K.W., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, The Journal of Alternative and Complementary Medicine. 2005, 11(6): 1047-1057.

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Law H.K.W., Flow cytometry applications in infection and immunity research: a personal experience, 11^th Annual General Meeting and Scientific Meeting, Hong Kong Society of Flow Cytometry, Hong Kong, 4 March 2006.

Li J., Law H.K.W., Lau Y.L. and Chan G.C.F., Different in vitro effects of chemotherapeutic agents on human mesenchymal stem cells, The Proceedings of The 10^th Congress of Bone Marrow Transplant Centre, The First Affiliated Hospital of Zhejiang University, Hangzhou, China, 13-16 October 2005. 61.

Liu S., Chan Y.K., Leung C.Y., Law H.K.W., Leung T.W. and Ngan H.Y.S., Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73a, Molecular Cancer Therapeutics. USA, American Association of Cancer Research, 2006, 5: 1209-1215.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses, 6^th Guangdong - Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006 (2^nd Prize in Poster Presentation). 2006, 38.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Functional Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Production by Avian Influenza Virus-Infected Macrophages, The Journal of Infectious Diseases. 2006, 193(7): 945-953.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Impairment of T lymphocytes activation in avian influenza: an in vitro study, 6th Guangdong – Hong Kong Paediatric Exchnage Meeting. China, 2006, 39.

Researcher : Law HY

List of Research Outputs

Law H.Y., 2005 Ferid Murad Award, 2005 Annual meeting of International Society for Interferon and cytokine Research, Shanghai, PR China, 20-24 October 2005. 2005.

Law H.Y., 2005 Milstein Travel Award, 2005 Annual meeting of International Society for Interferon and cytokine Research, Shanghai, PR China, 20-24 October 2005. 2005.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 211.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Resersch (Program & Abstracts from the 2005 Annual meeting of International Society for Interferon and cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10): 211.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of H5N1 Avian Influenza Virus Induced TNF-alpha dysregulation and a Delay in Apoptosis in Primary Blood Macrophages, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 100.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis. * Recipient of 2nd Prize Young Investigator Award., In: Davy C.W. Lee, Chris K.P. Mok, Chung-Yan Cheung, Anna H.Y. Law, Malik Peiris and Allan S.Y. Lau., 7th World Congress on Inflammation, 20 - 24 August 2005 in Melbourne, Australia.. 2005.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis, Inflammation Research (Official Journal of The International Societies, The European Histamine Research Society), 23 August 2005. 54: S181.

Lee D.C.W., Cheung C.Y., Law H.Y., Mok K.P., Peiris J.S.M. and Lau A.S.Y., p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Reponse to Avian Influenza Virus H5N1, Journal of Virology. 2005, 79(16): 10147-10154.

Researcher : Lee CW

List of Research Outputs

Lin S.S., Chua D.T.T., Lee C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression., In: Belinda S.S. Lin, Daniel T.T. Chua, Davy C.W. Lee, Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Researcher : Lee DCW

List of Research Outputs

Cheung B.K.W., Lee D.C.W., Li C.B., Lau Y.L. and Lau Y.L., A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression, Journal of Immunology. 2005, 175(11): 7218-7225.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-Stranded RNA-Activated Protein Kinase PKR in Bacillus Calmette Guerin (BCG)-Induced Cell Death, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 289.

Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Involvement of Double-stranded RNA-activated Protein Kinase PKR in Bacillus Calmétte Guerin (BCG)-induced Cell Death., In: Benny K.W. Cheung, Davy C.W. Lee and Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 211.

Law H.Y., Cheung B.K.W., Lee D.C.W. and Lau A.S.Y., Differential Regulation of Chemokine Expression by SARS-Coronavirus Genes, Cell Resersch (Program & Abstracts from the 2005 Annual meeting of International Society for Interferon and cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10): 211.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of H5N1 Avian Influenza Virus Induced TNF-alpha dysregulation and a Delay in Apoptosis in Primary Blood Macrophages, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 100.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis. * Recipient of 2nd Prize Young Investigator Award., In: Davy C.W. Lee, Chris K.P. Mok, Chung-Yan Cheung, Anna H.Y. Law, Malik Peiris and Allan S.Y. Lau., 7th World Congress on Inflammation, 20 - 24 August 2005 in Melbourne, Australia.. 2005.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis, Inflammation Research (Official Journal of The International Societies, The European Histamine Research Society), 23 August 2005. 54: S181.

Lee D.C.W., Cheung C.Y., Law H.Y., Mok K.P., Peiris J.S.M. and Lau A.S.Y., p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Reponse to Avian Influenza Virus H5N1, Journal of Virology. 2005, 79(16): 10147-10154.

Lin S.S., Lee D.C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) suppl: 218.

Researcher : Lee PPW

List of Research Outputs

Chan L.C., Lee P.P.W. and Patil N.G., Monograph 2: Problem-based Learning (PBL): Everything you want to know and are not afraid to ask, PBL - Its role and place in the medical curriculum. Institute of Medical and Health Scienced Education, HKU, 2006, 7-11.

Chiang A.K.S., Lee P.P.W., Li C.K., Yuen H.L., Lee A.C.W. and Li C.K., Treatment outcome of hepatocellular carcinoma and hepatoblastoma in children in Hong Kong, The 4^th congress of the International Society of Pediatric Oncology-Asia, Shanghai, PR China, 6-8 April 2006. 68.

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 45.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong, Pediatrics. 2006, 117(6): e1156-1162.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-stratified seroperevalence of SARS-coronarvirus (SARS-CoV) among children in Hong Kong, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 44.

Researcher : Lee RHK

List of Research Outputs

Lee R.H.K., Wong W.L., Chan C.H. and Chan S.Y., Differential Effects of Glial Cell Line-Derived Neurotrophic Factor and Neurturin in RET / GFRa1-Expressing Cells, Journal of Neuroscience Research. Wiley InterScience, 2006, 83: 80-90.

Researcher : Lee SL

List of Research Outputs

Lee L.L., Choi S.W.C., Hui C.C.K. and Lee S.L., Effect of insufflation exercise on force vital capacity and maximum insufflation capacity of patients with neuromuscular diseaes after spinal surgery, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 25.

Lee S.L., Wong W.H.S. and Lau Y.L., Association between air pollution and asthma admission among children in Hong Kong, Clinical and Experimental Allergy. Blackwell Publishing, 2006, 36: 1138-1146.

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N., Chung B.H.Y., Li Y.H., Goh W.H.S. and Lee S.L., Mutation of Gene in Spinal Muscular Atrophy Respiratory Distress Type I, Pediatric Neurology. 2006, 34(6): 474-477.

Researcher : Lee TL

List of Research Outputs

Chan K.W., Chen T., Jiang L., Fok S.F.S., Lee T.L., Lee B.W., Yang X. and Lau Y.L., Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing, International Journal of Immunogenetics. 2006, 33(3): 205-209.

Cheuk D.K.L., Lee T.L., Ha S.Y., Chan G.C.F., Lau Y.L. and Chiang A.K.S., Bone Marrow Transplantation for Hepatitis-associated Aplastic Anaemia: Case Reports and a Review of the Literature, Hong Kong Journal of Paediatrics (new series). 2006, 11: 32-38.

Chim S., Lee T.L., Chan S.Y. and Chan K.W., A case of tubulointerstitial nephritis and uveitis (TINU) syndrome treated with corticosteroid and mycophenolate mofetil, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 53.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 56.

Chow P.C., Ho M.H.K., Lee T.L., Lau Y.L. and Cheung Y.F., Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with systemic lupus erythematosus, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46.

Ha S.Y., Chan G.C.F., Chiang A.K.S., Lee A.C.W., Lee T.L. and Lau Y.L., Bone Marrow Transplantation for Fanconi Anaemia Using a Fludarabine-based Preparative Regimen with CD34+ Cell Selection, Hong Kong Journal of Paediatrics (new series). 2006, 11: 39-44.

Ho M.H.K., Chan G.C.F., Jones B.M., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Juvenile Pernicious Anaemia in Association with Vitiligo, Selective IgA Deficiency, Defective Interleukin 12 Production and T Cell Dysfunction, Hong Kong Journal of Paediatrics (new series). 2006, 11: 59-63.

Kwok J.S.Y., Hui K.H., Lee T.L., Wong W.H.S., Lau Y.L., Wong W.S., Kim D.L. and Jones B.M., Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population, Scandinavian Journal of Rheumatology. 2005, 34(5): 359-366.

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 45.

Lee T.L., Care of immuno-compromised patient, "Pediatric Oncology for Health Care Professionals" course organized by SPACE, HKU, 22 June 2006. 2006.

Lee T.L., Haematopoietic stem cell transplantation, "Pediatric Oncology for Health Care Professionals" course organized by SPACE, HKU, 22 June 2006. 2006.

Lee T.L., Prevention of Infection in Ummunocompromised Children, Crystal in Paediatrics. 2005, 6: 29-32.

Lee T.L., 東方日報, 幼年皮肌炎可致命, 2006.

Persquera-Lepatan L.M., Chan G.C.F., Lam C.C.K., Ho M.H.K., Lee T.L., Chiang A.K.S., Ha S.Y. and Lau Y.L., Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase, Hong Kong Journal of Paediatrics (new series). 2006, 11: 69-72.

Researcher : Leung MP

List of Research Outputs

Hui L., Chau A.K.T., Leung M.P. and Cheung Y.F., Dobutamine stress echocardiographic assessment of left ventricular function long after intervention for coronary artery fistula, 55^th Annual Scientific Session (Supplement to Journal of the American College of Cardiology), Atlanta, 11-14 March 2006. 47(4)(SupplA): 243A.

Researcher : Li CB

List of Research Outputs

Cheung B.K.W., Lee D.C.W., Li C.B., Lau Y.L. and Lau Y.L., A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression, Journal of Immunology. 2005, 175(11): 7218-7225.

Yim H.C.H., Li C.B. and Lau A.S.Y., Mechanism of HIV-Regulated Toll-like receptors expression., In: H.C.H. Yim, J.C.B. Li, A.S.Y. Lau., 10th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong. December 2005.

Researcher : Li CK

List of Research Outputs

Lee A.C.W., Chiang A.K.S., Shing M.M.K., Yuen H.L. and Li C.K., Treatment of Paediatric Non-Hodkin's Lymphoma: A Report of the Hong Kong Paediatric Haematology & Oncology Study Group, Turkish Journal of Haematology (Abstract published in the conference proceedings for XXXth World Congress of the International Society of Haematology 2005, Istanbul, Turkey, 28 September - 2 October 2005. 22(suppl): 245.

Ling S.C., Chan G.C.F., Shing M.M.K., Yuen H.L., Lee A.C.W., Chan C.W., Lee C.Y., Kwong K.S. and Li C.K., Children and Adolescents with Haemophilia in Hong Kong: An Epidemiological and Clinical Review, Hong Kong Journal of Pediatrics (new series). 2006, 11: 13-19.

Researcher : Li J

List of Research Outputs

Chan B.P., Leung M.K.H., Yeung C.W., Li J., Mo I. and Chan G.C.F., A novel 3-dimensiona culture system for human mesenchymal stem cells, International Society for Stem Cell Research 4th Annual Meeting. Toronto, Ontario, Canada, 2006, 98.

Chan G.C.F., Mo F.Y., Yip H.K., Li J., Law H.K.W. and Lau Y.L., Bacterial Endotoxin LPS but Not LTA Can Enhance Osteogenic Differentiation of Human Mesenchymal Stell Cells, Blood. 2005, 106(11): 138b.

Li J., Law H.K.W., Lau Y.L. and Chan G.C.F., Different in vitro effects of chemotherapeutic agents on human mesenchymal stem cells, The Proceedings of The 10^th Congress of Bone Marrow Transplant Centre, The First Affiliated Hospital of Zhejiang University, Hangzhou, China, 13-16 October 2005. 61.

Li J., Kwong D.L.W. and Chan G.C.F., Short term and prolonged effects of irradiation on human mesenchymal stem cells, Biology of Blood and Marrow Transplantation (Abstracts from the 2006 BMT Tandem Meetings), Honolulu, Hawaii, February 2006. 12(2): 108.

Researcher : Li YH

List of Research Outputs

Cheuk D.K.L., Wong V.C.N. and Li Y.H., No Association between VNTR Polymorphisms of Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder in Chinese Children, American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2006, 141B: 123-125.

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 25 novel and 2 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 62-63.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Lun K.S., Lam S.T.S., Tong T.M.F., Chung B.H.Y., Li Y.H., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 88.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N., Chung B.H.Y., Li Y.H., Goh W.H.S. and Lee S.L., Mutation of Gene in Spinal Muscular Atrophy Respiratory Distress Type I, Pediatric Neurology. 2006, 34(6): 474-477.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W. and Goh W.H.S., Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation (SMARD1) in Chinese Boy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Researcher : Liang Y

List of Research Outputs

Liang Y. and Chan S.Y., SUN2, a nuclear envelope protein protein associated with muscuclar disorders, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 76.

Liang Y. and Chan S.Y., Subcellular localization of sun2 is mediated by lamin and rab5, 10^th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 107.

Researcher : Lin SS

List of Research Outputs

Lin S.S., Chua D.T.T., Lee C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression., In: Belinda S.S. Lin, Daniel T.T. Chua, Davy C.W. Lee, Allan S.Y. Lau. , The 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR), Shanghai, China Oct. 20-24, 2005.. 2005.

Lin S.S., Lee D.C.W. and Lau A.S.Y., The Essential Role of Protein Kinase R in Mediating Latent Membrane Protein 1-regulated Cytokine Expression, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) suppl: 218.

Researcher : Low LCK

Project Title:	IDF WPR Childhood and Adolescence Diabcare 2003 - an audit and benchmarking study on Type 2 diabetes management in childhood and adolescence in Western Pacific region countries
Investigator(s):	Low LCK, Wong G.W.K., But B., Tse W., Cheng A., Lam Y.Y., Yu A., Wong L.M.
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2003

Abstract:

To describe diabetes control, diabetes management and complication status in children and adolescents with Type 2 diabetes mellitus in the WPR: a) to investigate the relationship between the above factors; b) to provide means of measuring the quality of diabetes management.

List of Research Outputs

Eppens M.C., Craig M.E., Jones T.W., Silink M., Ong S., Yeo J.P. and Low L.C.K., Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications (Acknowledgements - Members of the steering panel: Prof Louis Low (China-Hong Kong), Current Medical Research and Opinion. 2006, 22(5): 1013-1020.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Low L.C.K., 2nd National Thalassaemia Seminar 2006. Kuala Lumpur, Malaysia, 6-7 May 2006. 2006.

Low L.C.K., Approach to the Management of Short Normal Children, 河北醫學院大學第二醫院, 中國, Hebei University of Medical Sciences, 28-29 October 2005, Hebei University of Medical Sciences, 2005.

Low L.C.K., Board Director, Paediatrics, Journal of Paediatrics, Obstetrics & Gynaecology, (1997-date). 2006.

Low L.C.K., Chairman, Oral Session 4 "Diabetes complications", 31^st Annual Meeting of ISPAD, Krakow, Poland, 31 August 2005 - 3 September 2005. 2005.

Low L.C.K., Chairman, Organizing Committee , Asia Pacific Paediatric Endocrine Society Fellows Meeting. Wuhan PRC 4-6 Nov 2005. 2005.

Low L.C.K., 客座教授, Chongqing Children's Hospital, Chongqing University of Medical Society, Chongqing, PR China. 2005.

Low L.C.K., Convenor, FMSHK Members' Journal Abstract, Federation of Medical Societies of Hong Kong, (2000-date). 2006.

Low L.C.K., Diagnosis and management of congenital adrenal hyperplasia, National Endocrine Training Course, Children's Hospital of Fudan University, Shanghai PR China. 4-9 June 2006. Shanghai PR China, 2006.

Low L.C.K., Editorial Board Member (Jan 2005 - date), Pediatric Endocrinology Reviews. 2006.

Low L.C.K., Editorial Board Member, 2^nd Editorial Borad of the Chinese Journal of Contemporary Pediatrics. 2006.

Low L.C.K., Editorial Board Member, Expert Review of Endocrinology & Metabolism (March 2005-date). 2006.

Low L.C.K., Editorial Board Member, Journal of Paediatric Endocrinology & Metabolism (JPEM), (1997-date). 2006.

Low L.C.K., Editorial Board Member, Journal of Pediatric Endocrinology and Metabolism. 2006.

Low L.C.K., Editorial Director, Pediatric Endocrinology Reviews, Journal of Obstetrics Pediatrics and Gynecology. 2006.

Low L.C.K., Editorial and Metabolism Board Member, Pediatric Diabetes. 2006.

Low L.C.K., 客座教授, Hebei University of Medical Sciences, Habei. 2005.

Low L.C.K., Hyperandrogenism, Insulin Resistance and PCOS, Asia Pacific Paediatric Endocrine Society, Wuhan, PR China, 3-5 November 2005. 2005.

Low L.C.K., Hypogonadisom and its Management, Chongqing Children Hospital, Chongqing University of Medical Sciences, 31 October 2005. 2005.

Low L.C.K., Management of Precocious Puberty , Hebei University of Medical Sciences, 28-29 October 2005. 河北醫學院大學第二醫院, 中國, Hebei University of Medical Sciences, Hebei, China, 2005.

Low L.C.K., Meet-the-expert session, 2^nd National Thalassaemia Seminar, Kuala Lumpur, 7 May 2006. 2006.

Low L.C.K., Member of the Second Editorial Board of the Chinese Journal of Contemporary Pediatrics since (November 2003-date). 2006.

Low L.C.K., Member, Editorial Board (1999-date), Pediatric Diabetes. 2006.

Low L.C.K., Member, Scientific Committee,, 31st Annual Meeting of ISPAD, Krakow, Poland, 31 August 2005 - 3 September 2005. 2005.

Low L.C.K., Member, Scientific Committee, International Society for Pediatric and Adolescent Diabetes 2005-2006. 2006.

Low L.C.K., Pediatric Research (Nov 2003-date), Editorial Board Member, Combined Editorial Board . 2006.

Low L.C.K., Update of precocious puberty, 10th Anniversary Symposium of the Korean Society of Pediatric Endocrinology, Korea, 7-9 October . 2005.

Low L.C.K., 性早熟的診斷和治療, 全國兒科遺傳代謝 - 內分泌疾病診療新進展，武漢，中國， 4-8 July 2005, 2005.

Low L.C.K., 全國{兒科內分泌新理論, 新技術, 新進展} 學習班, 復旦大學附屬醫院, 上海, 中國, 4-11 June 2006, 2006.

Researcher : Lun KS

List of Research Outputs

Chau A.K.T., Chung B.H.Y., Lun K.S., Cheung Y.F. and Yung T.C., Midterm Outcomes of Transcatheter Closure of Atrial Septal Defect Using the Amplatzer Septal Occluder in Children, Hong Kong Journal of Paediatrics (new series). 2005, 10: 251-256.

Cheung Y.F., Chau A.K.T., Yung T.C. and Lun K.S., Transcatheter Closure of Right-to-Left Atrial Shunts Using Amplatzer Septal Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 265-270.

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Chow P.C., Lun K.S. and Chau A.K.T., Pulmonary vascular complications in children with chronic liver diseases, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 57.

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan H.C., Or S.F. and Lau Y.L., Identification of 25 novel and 2 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 62-63.

Lun K.S., Chau A.K.T., Yung T.C., Cheung Y.F., Cheng L.C. and Chiu C.S.W., Are we aggressive enough to treat acute fulminant myocarditis?, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 72.

Lun K.S., Lam S.T.S., Tong T.M.F., Chung B.H.Y., Li Y.H., Chan H.C., Or S.F. and Lau Y.L., Identification of 21 novel and 3 known FBN1 mutations in 66 unrelated Chinese probands with Marfan syndrome or Marfan-like phenotypes, Joint 6^th Human Genome Organization (HUGO) Pacific Meeting & 7^th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 88.

Lun K.S., Chiu C.S.W., Yung T.C., Cheung Y.F., Cheng L.C., Chau A.K.T. and Chau A.K.T., Intermediate-term Results of Repair of Congenital Heart Diseases Using Pulmonary Homografts, Hong Kong Journal of Paediatrics (new series). 2005, 10: 271-281.

Tam C.K.M., Lun K.S., Chau E.M.C. and Chau A.K.T., Sildenafil in the Management of Childhood Severe Idiopathic Pulmonary Arterial Hypertension: A Case Report, Hong Kong Journal of Paediatrics (new series). 2005, 10: 307-310.

Wong K.T., Chau A.K.T., Cheung Y.F., Yung T.C. and Lun K.S., Midterm Results of Transcatheter Closure of Moderate to Large-sized Patent Ductus Arteriosus Using the Amplatzer Duct Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 245-250.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Wong K.T., Yung T.C., Lun K.S., Fan K.Y.Y. and Chau A.K.T., Ten-year Experience of Radiofrequency Catheter Ablation of Accessory Pathways in Children and Young Adults, Hong Kong Journal of Paediatrics (new series). 2005, 10: 257-264.

Wong K.T., Yung T.C., Lun K.S., Fan K. and Chau A.K.T., Transcatheter radiofrequency ablation of supraventricular tachycardia in children and adolescents - immediate results and mid-term follow-up, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 71.

Researcher : Mi Y

List of Research Outputs

Mi Y. and Cheung Y.F., Assessment of right and left ventricular function by tissue Doppler echocardiography in patients after biventricular repair of pulmonary atresia with intact ventricular septum, International Journal of Cardiology. 2006, 109: 329-334.

Researcher : Mo FY

List of Research Outputs

Chan G.C.F., Mo F.Y., Yip H.K., Li J., Law H.K.W. and Lau Y.L., Bacterial Endotoxin LPS but Not LTA Can Enhance Osteogenic Differentiation of Human Mesenchymal Stell Cells, Blood. 2005, 106(11): 138b.

Researcher : Mok KP

List of Research Outputs

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., Mechanisms of H5N1 Avian Influenza Virus Induced TNF-alpha dysregulation and a Delay in Apoptosis in Primary Blood Macrophages, Cell Research (The 2005 Annual Meeting of International Society for Interferon & Cytokine Research), Shanghai, PR China, 20-24 October 2005. 15(10) Suppl: 100.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis. * Recipient of 2nd Prize Young Investigator Award., In: Davy C.W. Lee, Chris K.P. Mok, Chung-Yan Cheung, Anna H.Y. Law, Malik Peiris and Allan S.Y. Lau., 7th World Congress on Inflammation, 20 - 24 August 2005 in Melbourne, Australia.. 2005.

Lee D.C.W., Mok K.P., Cheung C.Y., Law H.Y., Peiris J.S.M. and Lau A.S.Y., The Paradox of H5N1 Avian Influenza Virus Infection in Primary Blood macrophages: TNF-alpha Hyper-induction and a Delay in Apoptosis, Inflammation Research (Official Journal of The International Societies, The European Histamine Research Society), 23 August 2005. 54: S181.

Lee D.C.W., Cheung C.Y., Law H.Y., Mok K.P., Peiris J.S.M. and Lau A.S.Y., p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Reponse to Avian Influenza Virus H5N1, Journal of Virology. 2005, 79(16): 10147-10154.

Researcher : Ng DKK

List of Research Outputs

Ng D.K.K., Cheung J.M., Leung S.Y., Chow P.Y., Wong W.H.S., Chan C.H. and Ho J.C.S., Prevalence of Sleep Problems in Hong Kong Primary School Children - A Community-Based Telephone Survey, Chest. 2005, 128: 1315-1323.

Researcher : Ng MW

List of Research Outputs

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Lau Y.L., Ng M.W., Peiris J.S.M., Pak S., Yung W.H., Chow Y., Au K.L., Chan Y.T., Lim W., Bonnevie-Nielsen V. and Field L.L., Innate immune response genes polymorphisms in SARS, 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 50.

Ng M.W., Lau W.C.S., Chan D.T.M., Wong W.H.S. and Lau Y.L., Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese., Rheumatology. 2005, 44(11): 1456-1457.

Researcher : Ng YM

List of Research Outputs

Ng Y.M., Sung R.Y.T., So L.Y., Fong N.C., Ho M.H.K., Cheng Y.W., Lee S.H., Mak W.C., Wong D.M.L., Yam M.C., Kwok K.L. and Chiu W.K., Kawasaki disease in Hong Kong, 1994 to 2000, Hong Kong Medical Journal. 2005, 11(5): 331-335.

Sung R.Y.T., Ng Y.M., Choi K.C., Mok G.C.F., Cheng Y.W. and Ho M.H.K., Lack of Associaton of Cervical Lymphadenopathy and Coronary Artery Complications in Kawasaki Disease, The Pediatric Infectious Disease Journal. 2006, 25(6): 521-525.

Researcher : Poon GWK

List of Research Outputs

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C. and Lam B.C.C., Regional white matter anisotropy and general intelligence in preterm born children: a voxelwise analysis, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005.

Researcher : So LY

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Tse H., Tsoi H.W., Cheng V.C.C., Lee P., Tang S.F., Cheung C.H.Y., Lee R.A., So L.Y., Lau Y.L., Chan K.H. and Yuen K.Y., Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong, Journal of Clinical Microbiology. 2006, 44(6): 2063-2071.

Ng Y.M., Sung R.Y.T., So L.Y., Fong N.C., Ho M.H.K., Cheng Y.W., Lee S.H., Mak W.C., Wong D.M.L., Yam M.C., Kwok K.L. and Chiu W.K., Kawasaki disease in Hong Kong, 1994 to 2000, Hong Kong Medical Journal. 2005, 11(5): 331-335.

Researcher : Tam THY

List of Research Outputs

Chan R.K.Y., Chu M., Ng M., Wong V., Tam T.H.Y., Tse G. and Wong V.C.N., Pilot study on the fine motor development of premature infants, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Wong V., Chan R.K.Y., Chu M., Tam T.H.Y., Cheung P. and Wong V.C.N., A review on sensory profile of children with developmental disabilities, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Researcher : To RWY

List of Research Outputs

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Yung A.W.Y., Ho W., To R.W.Y., Yuen S.M., Sze A. and Wong V.C.N., Developmental profiles of children with benign epilepsy wiht centro-temporal spikes, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Researcher : To YF

List of Research Outputs

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Researcher : Tsao YC

List of Research Outputs

Lam B.C.C., Tsao Y.C. and Hui Y., Clinical Practice Guideline on the Diagnosis and Management of Acute Otitis Media, Hong Kong Journal of Paediatrics. 2006, 11(1): 76-83.

Researcher : Tso HW

List of Research Outputs

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Researcher : Wong KT

List of Research Outputs

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Wong K.T., Chau A.K.T., Cheung Y.F., Yung T.C. and Lun K.S., Midterm Results of Transcatheter Closure of Moderate to Large-sized Patent Ductus Arteriosus Using the Amplatzer Duct Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 245-250.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Wong K.T., Yung T.C., Lun K.S., Fan K.Y.Y. and Chau A.K.T., Ten-year Experience of Radiofrequency Catheter Ablation of Accessory Pathways in Children and Young Adults, Hong Kong Journal of Paediatrics (new series). 2005, 10: 257-264.

Wong K.T., Yung T.C., Lun K.S., Fan K. and Chau A.K.T., Transcatheter radiofrequency ablation of supraventricular tachycardia in children and adolescents - immediate results and mid-term follow-up, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 71.

Researcher : Wong KY

List of Research Outputs

Chen W., Wong V.C.N. and Wong K.Y., Electrophysiologic and neurodevelopmental outcomes in neonate with hyperbilirubinemia, 10th Research Postgraduate Symposium, organized by the Faculty of Medicine, HKU (3 December, 2005). 2005.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental Outcome of Severe Neonatal Hemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(6): 474-479.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 39.

Chen W., Wong V.C.N. and Wong K.Y., Short and long term outcome of severe neonatal non-hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 40.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new Cause of Mental Retardation in a Young Chinese Girl: Congenital Disorder of Glycosylation, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 231.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new cause of mental retardation in a young Chinese girl: congenital disorder of glycosylation (CDG), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Leung K.Y., Chan K.L., Leung W.C., Lee C.P., Wong K.Y. and Tang M.H.Y., Endoscopic laser therapy for severe twin-twin transfusion syndrome: A case report, Journal of Paediatrics, Obstetrics and Gynaecology. 2005, Sep/Oct: 202-203.

Wong V.C.N., Chen W. and Wong K.Y., Short- and Long-Term Outcome of Severe Neonatal Nonhemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21: 309-315.

Researcher : Wong KY

List of Research Outputs

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental Outcome of Severe Neonatal Hemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(6): 474-479.

Wong V.C.N., Chen W. and Wong K.Y., Short- and Long-Term Outcome of Severe Neonatal Nonhemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21: 309-315.

Researcher : Wong OH

List of Research Outputs

Chiang A.K.S., Wong O.H. and Huang F., Functional Comparison of Cord and Adult Blood-Derived Dendritic Cells, Journal of Pediatric Haematology Oncology (Abstract published in the conference proceedings for 1^st Annual Fall Conference, Vancouver, Canada, 19-22 September 2005. 27(9): 463.

Chiang A.K.S., Wong O.H. and Huang F., Update on non-Hodgkin lymphomas, The Hong Kong Society of Haematology Monthly Scientific Meeting, Hong Kong, 15 August 2005.

To K.W., Wong O.H., Li H.B., Chan S.F., Ma L., Cheung Y.L., Ko K.H., Chiang A.K.S. and Huang F., The effects of Bergapten in modulating dendritic cells (DC) functions for DC-based tumor vaccines, 10th Research Postgraduate Symposium, Hong Kong. December 3. 2005.

Wong O.H., Huang F. and Chiang A.K.S., Differential responses of cord and adult blood-derived dendritic cells to dying cells, Immunology (Cover Story). 2005, 116: 13-20.

Researcher : Wong RMS

List of Research Outputs

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new Cause of Mental Retardation in a Young Chinese Girl: Congenital Disorder of Glycosylation, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 231.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new cause of mental retardation in a young Chinese girl: congenital disorder of glycosylation (CDG), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Researcher : Wong VCN

Project Title:	Functional polymorphism of the transporter gene MDR1 in epilepsy-gene frequency and relation with multi-drug resistance: a pharmaco-genetic study in Chinese epileptics
Investigator(s):	Wong VCN, Kwan P.
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To determine the gene frequency of MDR1 C3435T genotype in Chinese epileptics; to correlate the frequency of MDR1 C3435T genotype with clinical features including drug response in Chinese epileptic patients.

Project Title:	Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2
Investigator(s):	Wong VCN
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	01/2006

Abstract:

Rett syndrome (RTT) is an X-linked dominant neurodegenerative disorder characterized by a period of early normal growth and development followed by regression with loss of speech, acquired motor skills, stereotypic hand movement, and seizures. RTT affects 1 in 15,000 females and is the second leading cause of profound mental retardation in females. RTT is a clinical syndrome without any diagnostic biologic markers and the pathophysiologic changes has not been identified. The diagnosis of RTT is still reliant on clinical criteria. Early diagnosis of RS in the normal developmental period is still impossible. The disease is caused by mutations in the methyl-CpG-binding protein 2 gene (MECP2), and various mutations have been reported. The phenotypic spectrum in both female and male patients is diverse, ranging from very mild to congenital encephalopathy and prenatal lethality. Methyl-CpG binding protein 2 (MECP2) The responible gene, encoding Methyl-CpG binding protein 2 (MECP2) is discovered (1999 Sept 30). (1,2) MECP2 mutations is detected in < 50% of girls with RS by PCR amplification of the coding region. The RTT phenotype of MECP2 mutation is broad with lethality and normality in the two extremes. Findings have suggested that X-Chromosome Inactivation (XCI) pattern is the major determinant of the phenotype in females. MECP2 is an abundant chromosome-binding protein that selectively binds 5-methyl cytosine residues in CpG dinucleotides of mammalian genome. MECP2 has a role as a global transcriptional repressor in vertebrate genome. However, how MECP2 mutation cause RTT is still unclear as only 50% of RS girls has the mutation. MECP2 mutations has been detected by PCR amplification of the coding region. As MECP2 mutations could also involve the highly conserved regions within the 8.5-kb 3’UTR, mutational analysis should expand to include this region as well. Until now, MECP2 mutations has been detected by PCR amplification of the coding region in 60% of girls with RS. Possibly MECP2 mutations in the highly conserved regions within the 8.5-kb 3’UTR are currently underway. Both nonsense and missense mutations have been found. Different single-nucleotide deletion or insertion was found in patients with RS. Others are the nucleotide substitutions, which involve C-T transitions at CpG hotspots except one variant (G-A). Clinical Spectrum of Rett syndrome: The spectrum of phenotypes of MECP2 mutations seems to be much broader. R168X mutation was found in 2 affected sisters and their normal mother. In one family, an 806 del G deletion causing a V288X stop in the transcription-repression domain was identified in a woman with mild neuropyschological problems and skewed X inactivation; in her sister and daughter with classic RS and in her hemizygous son, who died from congenital encephalopathy. This finding suggested that X-chromosome inactivation (XCI) pattern could be the major determinant of the phenotype in females. The severity of RS is believed to be a function of the percentage of cells with active, mutated MECP2 genes. MECP2 gene encodes a protein called MeCP2 that helps to orchestrate the “rests” that certain genes must take during the developmental symphony. If a defective MeCP2 protein is unable to “conduct” gene expression, then a neural chaos will result.MeCP2 is actually just a member of a family of methyl-binding proteins, all of which may help to regulate gene function. Mutations in any of these proteins or their interacting partners may be responsible for atypical RS, autism, severe neonatal encephalopathy, and non-syndromal mental retardation. The spectrum of phenotypes of MECP2 mutations is surprisingly wide with lethality to normality in the two extremes. (3) Even though the mutational types could have contributed to the phenotypes, some findings suggested that the X-chromosome inactivation (XCI) pattern may be the major determinant of the phenotype in females. We had reported MECP2 mutation in a cohort of Chinese girls with RS and autism (2000). (4, 5) We hope to explore the spectrum of phenotypes resulting from MECP2 mutations in the Chinese population. We hope to establish a systemic way of mutational analysis of the gene in RS and its possible variant including girls with autism or autistic features, developmental stagnancy or regression in girls with unknown etiology, and severe neonatal encephalopathy. XCI pattern will be examined in the family in which the mutation has been detected. We aim to study mutational analysis of the MECP2 gene in other related neurodevelopmental disorder with similar core autistic or neurological regression features, e.g. girls with autism or autistic features, developmental stagnancy or regression girls without unknown etiology, and newborn with unexplained severe encephalopathy and non-syndromal mental retardation. XCI pattern will be examined in family members if mutation is detected. Long term objective: We hope that prenatal test to detect RS families can be available in families with affected daughters (though the risk is < 1%). We hope to test for asymptomatic daughters in RTT families early on (prefebly in stage 1) (< 12 months) such that an early diagnosis can be made or refuted to alleviate parental anxiety. Objective: To detect MECP2 mutation in children with Autistic traits including Rett syndrome, atypical Rett Syndrome, Autism, unexplained mental retardation and infantile epileptic encephalopathy

List of Research Outputs

Chan R.K.Y., Chu M., Ng M., Wong V., Tam T.H.Y., Tse G. and Wong V.C.N., Pilot study on the fine motor development of premature infants, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Chan T.Y.P. and Wong V.C.N., Recurrent Headache in Chinese Children: Any Agreement Between Clinician Diagnosis and Symptom-Based Diagnoses Using the International Classification of Headache Disorders (Second Edition)?, Journal of Child Neurology. 2006, 21(2): 132-138.

Chen W., Wong V.C.N. and Wong K.Y., Electrophysiologic and neurodevelopmental outcomes in neonate with hyperbilirubinemia, 10th Research Postgraduate Symposium, organized by the Faculty of Medicine, HKU (3 December, 2005). 2005.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental Outcome of Severe Neonatal Hemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(6): 474-479.

Chen W., Wong V.C.N. and Wong K.Y., Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 39.

Chen W. and Wong V.C.N., Prognosis of Bell's Palsy in children - an analysis of 29 cases, Brain & Development. 2005, 27(7): 504-508.

Chen W. and Wong V.C.N., Prognosis of Bell's palsy in children - Analysis of 29 cases, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 41.

Chen W., Wong V.C.N. and Wong K.Y., Short and long term outcome of severe neonatal non-hemolytic hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 40.

Chen W. and Wong V.C.N., Visual Evoked Potentials in Neonatal Hyperbilirubinemia, Journal of Child Neurology. 2006, 21(1): 58-62.

Chen W. and Wong V.C.N., Visual evoked potentials in neonatal hyperbilirubinemia, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 42.

Cheuk D.K.L. and Wong V.C.N., Acupuncture for epilepsy (Review), Cochrane Database Syst Rev. Wiley, 2006, 2: CD005062.

Cheuk D.K.L. and Wong V.C.N., Comorbidity pattern in Chinese children with attention deficit hyperactivity disorder, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Cheuk D.K.L., Wong V.C.N. and Leung G.M., Multilingual home environment and specific language impairment: a case-control study in Chinese children, Paediatric and Perinatal Epidemiology. Blackwell Publishing Ltd, 2005, 19(4): 303-314.

Cheuk D.K.L., Wong V.C.N. and Li Y.H., No Association between VNTR Polymorphisms of Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder in Chinese Children, American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2006, 141B: 123-125.

Cheuk D.K.L. and Wong V.C.N., Specific language impairment and child care by a domestic helper - A case-control study in Chinese children, Archives of Pediatrics & Adolescent Medicine. 2005, 159: 714-720.

Cheuk D.K.L. and Wong V.C.N., Specific language impairment and childcare by domestic helper: a case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Cheuk D.K.L., Wong V.C.N., Wraige E., Baxter P., Cole A., Elliott T. and Mayowe V., Surgery for scoliosis in duchenne muscular dystrophy (Protocol), The Cochrane Database of Systematic Reviews. 2005, 3: CD005375.

Cheuk D.K.L. and Wong V.C.N., To study the relationship of exposure to multilingual home environment and specific language impairment : a case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Cheuk D.K.L. and Wong V.C.N., Use of psychostimulant in Chinese children with attention deficit hyperactivity disorder, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Cheung K., Siu F. and Wong V.C.N., Medical Social Worker - a helping hand to the families in need, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Chung B.H.Y., Ip P., Wong V.C.N., Lo J., Nicholls J.M. and Khong P.L., Acute fulminant SSPE with absent measels and PCR studies in cerebrospinal fluid, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y. and Wong V.C.N., Clinical Markers Useful in Enhancing Diagnostic Yield for children with Global Developmental Delay (GDD), 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 134.

Chung B.H.Y. and Wong V.C.N., Clinical markers that enhance etiologic yield in global developmental delay (GDD), 1^st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 60.

Chung B.H.Y., Wat L.C.Y. and Wong V.C.N., Febrile Seizures in Southern Chinese Children: Incidence and Recurrence, Pediatric Neurology. 2006, 34(2): 121-126.

Chung B.H.Y., Wong V.C.N. and Wat L., Outcome of children with first febrile seizure – A local cohort study of 565 cases, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y. and Wong V.C.N., Pediatric Stroke in Southern Chinese, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Chung B.H.Y. and Wong V.C.N., Pediatric stroke in Southern Chinese, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal Muscular Atrophy (SMA) - Natural history and functional status in Hong Kong children, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006) Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Chung B.H.Y., Wong V.C.N., Ip P. and Hui L.H., Spinal muscular atrophy (SMA) – Natural history and functional status in Hong Kong Children, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease Type A (NPD-A), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Chung B.H.Y., Fung C.W., Li Y.H., Wong K.Y., Chan G.C.F. and Wong V.C.N., Two novel mutations of SMPD1 gene from a Chinese family with Niemann Pick Disease type A (NPD-A), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 64.

Fung C.W., Goh W.H.S. and Wong V.C.N., 2 patients with paroxysmal kinesigenic dyskinesia treatable with low dose carbamazepine, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency, a potentially treatable cause of dystonia, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Cheung P.T., Kwan E.Y.W., Poon G.W.K., Low L.C.K. and Wong V.C.N., 6-pyruvoyl-tetrahydropterin synthase deficiency: the clinical spectrum in 3 Chinese patients, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Fung C.W. and Wong V.C.N., A child with recurrent ataxia and lactic acidosis due to pyruvate dehydrogenase deficiency (PDH), DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new Cause of Mental Retardation in a Young Chinese Girl: Congenital Disorder of Glycosylation, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 231.

Fung C.W., Wong K.Y., Wong R.M.S., Goh W.H.S. and Wong V.C.N., A new cause of mental retardation in a young Chinese girl: congenital disorder of glycosylation (CDG), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W. and Wong V.C.N., Children with mesial temporal sclerosis (MTS) in an epilepsy cohort - a different clinical spectrum?, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 Mutation: From Asymptomatic Carrier to Stiff Man Syndrome, 4^th World Congress for NeuroRehabilitation (Abstract in Neurorehabilitation & Neural Repair). 2006, 20(1): 231.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 mutation: from asymptomatic carrier to stiff man syndrome, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S99.

Fung C.W., Lam C.W. and Wong V.C.N., DYT1 mutation: from asymptomatic carrier to stiff man syndrome, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Chung B.H.Y. and Wong V.C.N., Myasthenia gravis in Chinese children: Hong Kong perspective, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Fung C.W. and Wong V.C.N., Program for Chinese Children with Developmental Disabilities - The Hong Kong Model, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 203.

Fung C.W. and Wong V.C.N., Program for Chinese Children with Developmental Disabilities - The Hong Kong Model, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Fung C.W., Goh W.H.S. and Wong V.C.N., Suspected Leigh's disease: clinical spectrum in 2 cases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ho D. and Wong V.C.N., Visual development on premature infants in Hong Kong, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Environmental mercury exposure in children - South China's experience, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Wong V.C.N., Ho M.H.K., Lee J. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A Case-Control Study, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 171.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Chung B.H.Y. and Wong V.C.N., Neuromuscular disorders in Chinese children: Hong Kong's experience in past 17 years, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 42.

Ip P., Chung B.H.Y., Wong V.C.N., Chan K.Y., Wong T., Sugnan V.K., Wu S.P., Liu K.T., Yeung W.L. and Ieong K.M., Subacute Sclerosing Panencephalitis (SSPE) – prevalence in Southern China, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Kennerknecht I., Raman R., Wong V.C.N. and Edwards S., Hereditary prosopagnosia as a very common deficit - first worldwide survey, European Human Genetics Conference 2006, Amsterdam, The Netherlands, 6-9 May, 2006 (Abstract #P1143 in European Journal of Human Genetics). 2006, 14(Suppl 1): 350.

Lau K.S., Hung C.N., Shum S., Ngai C.F., Ho S.L., Ng K.S. and Wong V.C.N., Identifying prenatal, perinatal and environmental risk factors to autism spectrum disorder: case-control study, 10th Research Postgraduate Symposium. 2005.

Leung C., Zhou S.Z., Wong V.C.N. and Goh W.H.S., A comparative study of the quality of life of children with epilepsy in Shanghai and Hong Kong, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Leung C., Zhou S.Z., Wong V.C.N. and Goh W.H.S., A comparative study of the quality of life of children with epilepsy in Shanghai and Hong Kong, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Leung C., Goh W.H.S., Khong P.L. and Wong V.C.N., Thalamic T2 hyperintensities and cognitive function in Chinese children with neurofibromatosis, Type I, DK 50th Anniversary Symposium on Paediatric Neuroloyg and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Lui C.H.T., Kwan P., Wong V.C.N. and Yeung J.H.M., Mortality of Epilepsy - A retrospective cohort analysis in Hong Kong, 18th Annual Scientific Meeting of the Hong Kong Neurological Society (Hong Kong, October 29-30, 2005). 2005.

Ma Y.M. and Wong V.C.N., Clinical spectrum of Guillain Barre syndrome: a twenty-nine-year experience (1977-2005), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Martins S., Calafell F., Wong V.C.N., Sequeiros J. and Amorim A., A multistep mutation mechanism drives the evolution of the CAG repeat at MJD/SCA3 locus, European Journal of Human Genetics. 2006, 14: 932-940.

Ng S.M., Chow B.K.C. and Wong V.C.N., The human secretin gene in children with autistic spectrum disorder: screening for polymorphisms and mutations., Journal of Child Neurology. 2005, 20(8): 701-704.

Siu F., Cheung K. and Wong V.C.N., Respite care for disabled child at the Children Habilitation Institute (CHI), DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Wong V., Chan R.K.Y., Chu M., Tam T.H.Y., Cheung P. and Wong V.C.N., A review on sensory profile of children with developmental disabilities, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation in Chinese Boy, 4th World Congress for NeuroRehabilitation (Hong Kong, 12-16 February, 2006). 2006.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W., Ip P., Goh W.H.S. and Lee S.L., (SMARD1) Spinal Muscular Atrophy with respiratory distress type 1 mutation in Chinese boy, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 65.

Wong V.C.N., Leung C., Zhou S.Z. and Goh W.H.S., A Comparative Study of the Quality of Life of Children with Epilepsy in Shanghai and Hong Kong, 4^th World Congress for NeuroRehabilitation, Hong Kong, February 12-16, 2006, Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 181.

Wong V.C.N., Lam C.W. and Fung C.W., An unusual phenotype in DYT1 dystonia: stiff man syndrome, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Wong V.C.N. and Chung B.H.Y., Causes of global developmental delay (GDD) in Southern Chinese, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., Causes of global developmental delay (GDD) in southern Chinese, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 59.

Wong V.C.N., Chairperson, Organizing Committee of DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (16-17 September, 2005). 2005.

Wong V.C.N. and Chung B.H.Y., Clinical markers useful in enhancing diagnostic yield for children with global developmental delay (GDD), DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., Clinical markers useful in enhancing diagnostic yield for children with global developmental delay (GDD), Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 60.

Wong V.C.N., Co-Chair person in Symposium on Epilepsy (3 Dec), Brain 2005 (2-3 December). 2005.

Wong V.C.N., Co-Chairperson for Plenary Session on "Complementary/Alternative Medicine", 10th International Child Neurology Congress (Montreal, Canada, 11-16 June, 2006). 2006.

Wong V.C.N., Au-Yeung T.Y.C. and Law P.K., Correlation of Functional Independence Measure for Children (WeeFIM) with Developmental Language Tests in children with developmental delay, Journal of Child Neurology. 2005, 20(7): 613-616.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 133.

Wong V.C.N., Chung B.H.Y., Hui L.H., Fong A., Lau C., Law B., Lo K., Sham T. and Wong R., Correlation of functional assessment with risk factors in children with cerebral palsy, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N., Duchenne Muscular Dystrophy And Spinal Muscular Atrophy, 2005.

Wong V.C.N., Epidemiology and Risk Factors for Childhood Stroke in Chinese Children, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26(Supple): S2.

Wong V.C.N. and Chung B.H.Y., Evaluating a Child with Partial Developmental Delay (ParDD), Global Developmental Delay (GDD) / Mental Retardation (MR): Clinical Expertise Based or Evidence-Based?, Current Pediatric Reviews. Bentham Science Publishers, 2006, 292): 143-153.

Wong V.C.N., Examiner, MRCPCH Clinical Exam (31 October - 1 November 2005). 2005.

Wong V.C.N., Lau K.S., Hung C.N., Shum T., Ngai C.F., Ho S.L. and Ng K.S., Identifying prenatal, perinatal and environmental risk factors for autism spectrum disorder (ASD): a case-control study, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S168.

Wong V.C.N., Integration of Traditional Chinese Medicine (Acupuncture) & Western Medicine in Child Neurology, 10th International Child Neurology Congress, Montreal, Canada, 11-16 June, 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S111.

Wong V.C.N., Moderator, Session on "Paediatric Movement Disorders I" in DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation (16-17 September, 2005). 2005.

Wong V.C.N., Chung B.H.Y., Li Y.H., Goh W.H.S. and Lee S.L., Mutation of Gene in Spinal Muscular Atrophy Respiratory Distress Type I, Pediatric Neurology. 2006, 34(6): 474-477.

Wong V.C.N., Organizer, Symposium on Autism 2006: Diagnosis & Management (Hong Kong, 14-19 January, 2006). 2006.

Wong V.C.N. and Chung B.H.Y., Pediatric Stroke in Southern Chinese, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 186.

Wong V.C.N., Sun J.G. and Yeung D.W., Pilot Study of Positron Emission Tomography (PET) Brain Glucose Metabolism to Assess the Efficacy of Tongue and Body Acupuncture in Cerebral Palsy, Journal of Child Neurology. 2006, 21(6): 456-462.

Wong V.C.N., Sun J.G. and Yeung D.W., Pilot study of efficacy of tongue and body acupuncture in children with visual impairment, Journal of Child Neurology. 2006, 21(6): 462-473.

Wong V.C.N., Sensory Integration Therapy For Children With Developmental Disabilities. 2005.

Wong V.C.N., Chen W. and Wong K.Y., Short- and Long-Term Outcome of Severe Neonatal Nonhemolytic Hyperbilirubinemia, Journal of Child Neurology. 2006, 21: 309-315.

Wong V.C.N., Chung B.H.Y., Li Y.H., Fung C.W. and Goh W.H.S., Spinal Muscular Atrophy with Respiratory Distress Type 1 Mutation (SMARD1) in Chinese Boy, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 112.

Wong V.C.N., Lam C.W. and Fung C.W., Stiff Child Syndrome with Mutatin of DYT1 gene, Neurology. 2005, 65(9): 1465-1466.

Wong V.C.N., Study of the relationship between tuberous sclerosis complex and autistic disorder, Journal of Child Neurology. 2006, 21: 199-204.

Wong V.C.N. and Chung B.H.Y., Survey of public awareness, understanding, and attitudes towards epilepsy in Hong Kong – A comparison of Chinese and Western culture, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005.

Wong V.C.N. and Chung B.H.Y., To identify causes and clinical markers for increasing diagnostic yield for children with global developmental delay (GDD), 10th International Child Neurology Congress, Montreal, Canada, 11-16 June 2006 (Abstract published in Neuropediatrics). 2006, 26 (Supple): S96.

Wong V.C.N. and Khong P.L., Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings with Comorbidities, Journal of Child Neurology. 2006, 21(2): 99-105.

Yung A.W.Y., Ho W., To R.W.Y., Yuen S.M., Sze A. and Wong V.C.N., Developmental profiles of children with benign epilepsy wiht centro-temporal spikes, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Researcher : Wong WHS

List of Research Outputs

Chong W.P., Wong W.H.S., Chiu C.S. and Cheung Y.F., Aortic Root Dilation is Related to Aortic Stiffening in Children after Repair of Tetralogy of Fallot, Supplement to Circulation (Abstract from American Heart Association, Scientific sessions 2005, Dallas, Texas, USA), 13-16 November 2005. 112(17): 2288.

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Chong W.P., Ip E.W.K., Tso H.W., Ng M.W., Wong W.H.S., Law H.K.W., Yung R.W.H., Chow E.Y., Au K.L., Chan E.Y.T., Lim W., Peiris J.S.M. and Lau Y.L., The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome, BMC Infectious Diseases. 2006, 6: 82.

Chong W.Y., Wong W.H.S., Chiu C.S.W. and Cheung Y.F., Aortic Root Dilation and Aortic Elastic Properties in Children After Repair of Tetralogy of Fallot, The American Journal of Cardiology. 2006, 97: 905-909.

Ho M.H.K., Heine R.G., Wong W.H.S. and Hill D.J., Diagnostic accuracy of skin prick testing in children with tree nut allergy, Journal of Allergy Clinical Immunology. 2006, 117(6): 1506-1508.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Environmental mercury exposure in children - South China's experience, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Ip P., Wong V.C.N., Ho M.H.K., Lee J. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A Case-Control Study, 4^th World Congress for NeuroRehabilitation (Hong Kong, February 12-16, 2006), Abstract in Neurorehabilitation & Neural Repair, 20(1). 2006, 20(1): 171.

Ip P., Wong V.C.N., Ho M.H.K., Lee J.S.K. and Wong W.H.S., Mercury Exposure in Children with Autistic Spectrum Disorder: A case-control study, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Kwok J.S.Y., Hui K.H., Lee T.L., Wong W.H.S., Lau Y.L., Wong W.S., Kim D.L. and Jones B.M., Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population, Scandinavian Journal of Rheumatology. 2005, 34(5): 359-366.

Lee P.P.W., Lee T.L., Ho M.H.K., Wong W.H.S. and Lau Y.L., Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 45.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-Stratified Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus Among Children in Hong Kong, Pediatrics. 2006, 117(6): e1156-1162.

Lee P.P.W., Wong W.H.S., Leung G.M., Chiu S.S.S., Chan K.H., Peiris J.S.M., Lam T.H. and Lau Y.L., Risk-stratified seroperevalence of SARS-coronarvirus (SARS-CoV) among children in Hong Kong, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, 7 January 2006, Queen Elizabeth Hospital. 2006, 44.

Lee S.L., Wong W.H.S. and Lau Y.L., Association between air pollution and asthma admission among children in Hong Kong, Clinical and Experimental Allergy. Blackwell Publishing, 2006, 36: 1138-1146.

Ng D.K.K., Cheung J.M., Leung S.Y., Chow P.Y., Wong W.H.S., Chan C.H. and Ho J.C.S., Prevalence of Sleep Problems in Hong Kong Primary School Children - A Community-Based Telephone Survey, Chest. 2005, 128: 1315-1323.

Ng M.W., Lau W.C.S., Chan D.T.M., Wong W.H.S. and Lau Y.L., Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese., Rheumatology. 2005, 44(11): 1456-1457.

To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005.

Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54.

Wong W.H.S. and Fong D.Y.T., Statistical Corner, Journal of Paediatric Respirology and Critical Care. Hong Kong, Hong Kong Society of Paediatric Respirology, 2006, 2(1): 14.

Wong W.H.S. and Fong D.Y.T., Statistical Corner, Journal of Paediatric Respirology and Critical Care. Hong Kong, Hong Kong Society of Paediatric Respirology, 2005, 1(4): 14.

Wong W.H.S. and Fong D.Y.T., Statistical Corner, In: Daniel Ng, Journal of Paediatric Respirology and Critical Care. Hong Kong, Hong Kong Society of Paediatric Respirology, 2005, 1(3): 14.

Yip H.K., Jin C., Chan S., Zhang T., Wong W.H.S., Fang H.H.P. and Chan G.C.F., Titanium Surface Treatments and Growth of Human Mesenchyamal Stem Cells, Journal of Dental Research, 35th the AADR/CADR Annual Meeting & Exhibition, March 3-9, 2006, Orlando, Florida, USA. USA, International Association for Dental Research, 2006, abstract no. 2008.

Researcher : Yeung CY

List of Research Outputs

Fung Y.S., Sun D. and Yeung C.Y., Capillary electrophoresis for binding study of bilirubin to human serum proteins, Abstract of 8^th Asian Conference on Analytical Sciences (Asianalysis VIII), Taipei, Taiwan, October 16-20, 2005. KA-06: 62.

Fung Y.S., Sun D. and Yeung C.Y., Capillary electrophoresis for binding study of bilirubin to human serum proteins, Invited Lecture at 8^th Asian Conference on Analytical Science (Asianalysis VIII), Taipei, Taiwan, October 16-20, 2005. 2005.

Ng P.K., Hui Y., Lam B.C.C., Goh W.H.S. and Yeung C.Y., Feasibility of implementing a universal neonatal hearing screening program by dpoae detection at a university hospital in Hong Kong, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 41.

Researcher : Yick LW

Project Title:	Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation
Investigator(s):	Yick LW, Chan SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To understand the role of EGF in chondrocyte differentiation using our 'knock-in mice' with targeted expression of EGF in prehypertrophic chondrocytes.

List of Research Outputs

Chan S.Y., Chan K.W., Yick L.W. and Fong S.W., Transgenic expression of testis specific protein Y-encoded-like 2 triggers developmental and behavioral changes, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S117.

Researcher : Yim HCH

List of Research Outputs

Yim H.C.H., Li C.B. and Lau A.S.Y., Mechanism of HIV-Regulated Toll-like receptors expression., In: H.C.H. Yim, J.C.B. Li, A.S.Y. Lau., 10th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong. December 2005.

Researcher : Yung AWY

List of Research Outputs

Hui C.C.K., Lee L.L., Choi S.W.C. and Yung A.W.Y., Rehabilitative outcome and subjective feedback of patients having epilepsy surgery, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 29.

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C. and Lam B.C.C., Regional white matter anisotropy and general intelligence in preterm born children: a voxelwise analysis, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14^th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.

Yung A.W.Y., Leung C., Sze A., Khong P.L., Ho W.Y., Yuen S.M. and Fan Y.W., Clinical outcome in four patients after epilepsy surgery, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 49.

Yung A.W.Y., Ho W., To R.W.Y., Yuen S.M., Sze A. and Wong V.C.N., Developmental profiles of children with benign epilepsy wiht centro-temporal spikes, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005.

Yung A.W.Y., Talk on post-surgical rehabilitation management of Wing Tung to all therapists, childcare workers and nurses, Jockey Club Marion Fang Conductive Learning Centre, The Spastics Association of Hong Kong, 27 April 2006. 2006.

Yung A.W.Y., Chan J., Sze A. and Yuen S.M., The use of ketogenic diet program in the treatment of children with intractable epilepsy: A local experience, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 53.

Yung A.W.Y., Video highlight of Wing Tung's training program and discussion with the childcare and therapist in-charge of the child, Jockey Club Marion Fang Conductive Learning Centre, The Spastics Association of Hong Kong, 27 April 2006. 2006.

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005.

Yung A.W.Y., 癲癇及腦性癱瘓對學習的影響, 明愛樂勤學校 – 邀請家長講座, 25 April 2006, 2006.

Researcher : Yung TC

List of Research Outputs

Chau A.K.T., Chung B.H.Y., Lun K.S., Cheung Y.F. and Yung T.C., Midterm Outcomes of Transcatheter Closure of Atrial Septal Defect Using the Amplatzer Septal Occluder in Children, Hong Kong Journal of Paediatrics (new series). 2005, 10: 251-256.

Cheung Y.F., Chau A.K.T., Yung T.C. and Lun K.S., Transcatheter Closure of Right-to-Left Atrial Shunts Using Amplatzer Septal Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 265-270.

Chow P.C., Cheung E.W.Y., Chong C.Y., Lun K.S., Yung T.C., Wong K.T., Chau A.K.T. and Cheung Y.F., Brain Natriuretic Peptide as a Biomarker of Systemic Ventricular Function in Patients with Transposition of Great Arteries after Senning or Mustard Operation, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Lun K.S., Chau A.K.T., Yung T.C., Cheung Y.F., Cheng L.C. and Chiu C.S.W., Are we aggressive enough to treat acute fulminant myocarditis?, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 72.

Lun K.S., Chiu C.S.W., Yung T.C., Cheung Y.F., Cheng L.C., Chau A.K.T. and Chau A.K.T., Intermediate-term Results of Repair of Congenital Heart Diseases Using Pulmonary Homografts, Hong Kong Journal of Paediatrics (new series). 2005, 10: 271-281.

McManus A.M., Cheng C.H., Leung M.P., Yung T.C. and Macfarlane D.J., Improving aerobic power in primary school boys: a comparison of continuous and interval training. , International Journal of Sports Medicine. Germany, Thieme, 2005, 26: 781-786.

Tsang F.H.F., Cheng L.C., Yung T.C., Chau A.K.T. and Chiu C.S.W., Ligation of Patent Ductus Arteriosus for Premature Infants in Intensive Care Unit, Hong Kong Journal of Paediatrics (new series). 2005, 10: 282-285.

Wong K.T., Chau A.K.T., Cheung Y.F., Yung T.C. and Lun K.S., Midterm Results of Transcatheter Closure of Moderate to Large-sized Patent Ductus Arteriosus Using the Amplatzer Duct Occluder, Hong Kong Journal of Paediatrics (new series). 2005, 10: 245-250.

Wong K.T., Chow P.C., Chong C.Y., Yung T.C., Lun K.S., Chau A.K.T. and Cheung Y.F., Relation of QRS duration and QT dispersion to Right Ventricular Function in Patients Late After Atrial Switch Operation for Transposition of Great Arteries, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 47.

Wong K.T., Yung T.C., Lun K.S., Fan K.Y.Y. and Chau A.K.T., Ten-year Experience of Radiofrequency Catheter Ablation of Accessory Pathways in Children and Young Adults, Hong Kong Journal of Paediatrics (new series). 2005, 10: 257-264.

Wong K.T., Yung T.C., Lun K.S., Fan K. and Chau A.K.T., Transcatheter radiofrequency ablation of supraventricular tachycardia in children and adolescents - immediate results and mid-term follow-up, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 71.

Researcher : Zhou J

List of Research Outputs

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses, 6^th Guangdong - Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006 (2^nd Prize in Poster Presentation). 2006, 38.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Functional Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Production by Avian Influenza Virus-Infected Macrophages, The Journal of Infectious Diseases. 2006, 193(7): 945-953.

Zhou J., Law H.K.W., Cheung C.Y., Ng I.H.Y., Peiris J.S.M. and Lau Y.L., Impairment of T lymphocytes activation in avian influenza: an in vitro study, 6th Guangdong – Hong Kong Paediatric Exchnage Meeting. China, 2006, 39.

Zhou J. and Lau Y.L., 變種病毒人傳人之謎, 流感, 禽流感真貌, Hong Kong, 明窗, 2006, Chapter 4: 29-38.

Researcher : Zhou J

List of Research Outputs

Zhou J. and Lau Y.L., 變種病毒人傳人之謎, 流感, 禽流感真貌, Hong Kong, 明窗, 2006, Chapter 4: 29-38.

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