Dept of Clinical Oncology

DEPT OF CLINICAL ONCOLOGY

Researcher : Au GKH

List of Research Outputs

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Researcher : Au SK

List of Research Outputs

Cheng H.C., Wu V.W., Ngan K.C., Tang K.W., Chan C.C., Wong K.H., Au S.K. and Kwong D.L.W., A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients, Radiother Oncol. 2012.

Researcher : Chan HM

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Fan H., Chen L., Zhang F., Quan Y., Su X., Qiu X., Zhao Z., Kong K.L., Song Y., Chan H.M. and Guan X., MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. , Oncogene. 2012, 31: 2298-2308.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Researcher : Chen J

List of Research Outputs

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Researcher : Chen L

Project Title:	Clinical Significance of CHD1L and Therapeutic potentials of Virus-mediated CHD1L Depletion in Hepatocellular Carcinoma
Investigator(s):	Chen L, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	01/2012

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Fan H., Chen L., Zhang F., Quan Y., Su X., Qiu X., Zhao Z., Kong K.L., Song Y., Chan H.M. and Guan X., MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. , Oncogene. 2012, 31: 2298-2308.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Li J., Yang H., Chen L., Li Y., Zhu Y., Dai Y., Chen K., Ai J., Zeng T., Mao X., Liu L., Li X. and Guan X., Establishment and characterization of human non-small cell lung cancer cell lines. , Mol Med Report. 2012, 5(1): 114-117.

Li J., Lau G.K., Chen L., Dong S., Lan H.Y., Huang X.R., Li Y., Luk J.M., Yuan Y.F. and Guan X., Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression, PLoS One. 2011, 6: e21816.

Li Y., Chen L., Nie C.J., Zeng T.T., Liu H., Mao X., Qin Y., Zhu Y.H., Fu L. and Guan X., Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2011, 71(19): 6106-6115.

Lin H., Hu L., Chen L., Yu H., Wang Q., Chen P., Hu X.T., Cai X.J. and Guan X., Chemically-induced cancers do not originate from bone marrow-derived cells., PLoS One. 2012, 7: e30493.

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Wang J., Chen L., Li Y. and Guan X., Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. , PLoS One. 2011, 6(9): e24967.

Researcher : Cheng Y

Project Title:	Reprogramming of nasopharyngeal carcinoma cells by genetic correction after chromosome transfer
Investigator(s):	Cheng Y, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	08/2010
Completion Date:	07/2012

Project Title:	Wnt-signaling defines cancer stem cells and epithelial-mesenchymal transition
Investigator(s):	Cheng Y, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2012

Project Title:	American Association for Cancer Research Annual Meeting Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids
Investigator(s):	Cheng Y
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	04/2012

List of Research Outputs

Cheng Y., In: Cheng Yue , Name of Book: Tumor Suppressor Genes . 肿瘤抑制基因, Rijeka, Croatia, InTech, 2011, 13 chapters: 332 pages.

Cheng Y., Cheung A.K.L., Ko J.M.Y., Phoon Y.P. and Lung M.L., Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids , American Association for Cancer Research 103rd Annual Meeting. AACR, 2012.

Huang Z., Cheng Y., Chiu P.M., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2011.

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Deciphering the molecular genetic basis of NPC through functional approaches, Semin Cancer Biol. 2012.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer. , In: Peter Yue Cheng , Tumor Suppressor Genes . InTech Open Access Publisher, 2011.

Researcher : Cheung AKL

Project Title:	Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):	Cheung AKL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Cheng Y., Cheung A.K.L., Ko J.M.Y., Phoon Y.P. and Lung M.L., Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids , American Association for Cancer Research 103rd Annual Meeting. AACR, 2012.

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Deciphering the molecular genetic basis of NPC through functional approaches, Semin Cancer Biol. 2012.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer. , In: Peter Yue Cheng , Tumor Suppressor Genes . InTech Open Access Publisher, 2011.

Lung H.L., Cheung A.K.L., Chung Y.M., Liu E.T.B., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma (NPC), Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Ip J.C.Y., Zabarovsky E. and Stanbridge E.J., Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago. 2012.

Researcher : Cheung WY

List of Research Outputs

Lung M.L., Ko J.M.Y., Cheung W.Y. and Yu Z., Characterization of PHF11, a candidate tumor suppressor gene, in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Researcher : Chiu PM

List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2011.

Researcher : Choy TS

List of Research Outputs

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Researcher : Chua DTT

Project Title:	2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2000

Project Title:	2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2004

Project Title:	Nasopharyngeal Carcinoma (NPC)
Investigator(s):	Chua DTT, Nicholls JM
Department:	Clinical Oncology
Source(s) of Funding:	Croucher Foundation - Research Grants
Start Date:	01/2007

List of Research Outputs

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.

Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T., Chau J. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement, BMC Cancer. 2011, 11: 288.

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Researcher : Dong S

List of Research Outputs

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Li J., Lau G.K., Chen L., Dong S., Lan H.Y., Huang X.R., Li Y., Luk J.M., Yuan Y.F. and Guan X., Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression, PLoS One. 2011, 6: e21816.

Ma N.F., Lau B.S.H., Hu L., Dong S. and Guan X., Hepatitis B virus X gene in the development of hepatocellular carcinoma. , Hong Kong Med J . 2011, 17 Suppl 6: 44-47.

Zhu W., Cai M.Y., Tong Z.T., Dong S., Mai S.J., Liao Y.J., Bian X.W., Lin M.C., Kung H.F., Zeng Y.X., Guan X. and Xie D., Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. , Gut. 2012, 61: 562-575.

Researcher : Dong S

List of Research Outputs

Ma N.F., Lau B.S.H., Hu L., Dong S. and Guan X., Hepatitis B virus X gene in the development of hepatocellular carcinoma. , Hong Kong Med J . 2011, 17 Suppl 6: 44-47.

Researcher : Fu L

Project Title:	Characterization of a novel tumor susceptibility gene PSCA in esophageal squamous cell carcinoma
Investigator(s):	Fu L, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011

Project Title:	Epigenetic Alteration of Organic Cation Transporter Gene SLC22A3 Confers Susceptibility To Esophageal Cancer in The High-Risk Northern Chinese
Investigator(s):	Fu L, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Li Y., Chen L., Nie C.J., Zeng T.T., Liu H., Mao X., Qin Y., Zhu Y.H., Fu L. and Guan X., Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2011, 71(19): 6106-6115.

Liu H., Qin Y.R., Bi J., Guo A., Fu L. and Guan X., Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma., Dis Esophagus. 2011.

Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.

Xie F.J., Zhao P., Kou J.Y., Hong W., Fu L., Hu L., Hong D., Su D., Gao Y. and Zhang Y.P., The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum., Cancer Chemotherapy and Pharmacology. Springerlink, 2012, 69: 1443-1448.

Researcher : Guan X

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2011

Project Title:	Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011

Project Title:	Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Cai M.Y., Tong Z.T., Zhu W., Wen Z.Z., Rao H.L., Kong L.L., Guan X., Kung H.F., Zeng Y.X. and Xie D., H3K27me3 Protein Is a Promising Predictive Biomarker of Patients' Survival and Chemoradioresistance in Human Nasopharyngeal Carcinoma. , Mol Med . 2011, 17: 1137-1145.

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Fan H., Chen L., Zhang F., Quan Y., Su X., Qiu X., Zhao Z., Kong K.L., Song Y., Chan H.M. and Guan X., MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. , Oncogene. 2012, 31: 2298-2308.

Fang J.H., Zhou H.C., Zeng C., Yang J., Liu Y., Huang X., Zhang J.P., Guan X. and Zhuang S.M., MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. , Hepatology. 2011, 54(5): 1729-1740.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Li J., Yang H., Chen L., Li Y., Zhu Y., Dai Y., Chen K., Ai J., Zeng T., Mao X., Liu L., Li X. and Guan X., Establishment and characterization of human non-small cell lung cancer cell lines. , Mol Med Report. 2012, 5(1): 114-117.

Li J., Lau G.K., Chen L., Dong S., Lan H.Y., Huang X.R., Li Y., Luk J.M., Yuan Y.F. and Guan X., Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression, PLoS One. 2011, 6: e21816.

Li Y., Chen L., Nie C.J., Zeng T.T., Liu H., Mao X., Qin Y., Zhu Y.H., Fu L. and Guan X., Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2011, 71(19): 6106-6115.

Lin H., Hu L., Chen L., Yu H., Wang Q., Chen P., Hu X.T., Cai X.J. and Guan X., Chemically-induced cancers do not originate from bone marrow-derived cells., PLoS One. 2012, 7: e30493.

Liu H., Qin Y.R., Bi J., Guo A., Fu L. and Guan X., Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma., Dis Esophagus. 2011.

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Lu S., Lu L.Y., Yuan Q.J., Sham M.H., Guan X. and Huang J., Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood, Neurobiology of Disease. 2011, 45: 219-233.

Ma N.F., Lau B.S.H., Hu L., Dong S. and Guan X., Hepatitis B virus X gene in the development of hepatocellular carcinoma. , Hong Kong Med J . 2011, 17 Suppl 6: 44-47.

Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.

Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.

Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.

Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.

Tong M., Ma S.K.Y. and Guan X., Biology of hepatic cancer stem cells, Journal of Gastroenterology and Hepatology. 2011, 26: 1229-37.

Wang Z., Cheng Y., Wang N., Wang D.M., Li Y.W., Han F., Shen J., Yang D.P., Guan X. and Chen J., Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins., Cancer Biology & Therapy . 2012, 13(3): 138-147.

Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. , Cancer. 2012, 118: 698-710.

Wong A.M.G., Guan X. and Tsang J.W.H., Response to "Potential of circulating viral microRNAs as novel biomarkers for nasopharyngeal carcinomas", Cancer. 2011.

Yeung W.H., Lee K.W., Geng W., Li C., Ng K.T.P., Lo C.M., Guan X., Poon R.T.P., Fan S.T. and Man K., M2 macrophages promotes tumor growth and invasion in hepatocellular carcinoma, The 18th Annual International Congress of the International Liver Transplantation Society, San Francisco, California, U.S.A., 16 - 19 May 2012.

Zhang F., Liao Y.J., Cai M.Y., Liu Y.H., Liu T.H., Chen S.P., Bian X.W., Guan X., Lin M.C., Zeng Y.X., Kung H.F. and Xie D., The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. , Gut. 2012, 61: 278-289.

Zhu W., Cai M.Y., Tong Z.T., Dong S., Mai S.J., Liao Y.J., Bian X.W., Lin M.C., Kung H.F., Zeng Y.X., Guan X. and Xie D., Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. , Gut. 2012, 61: 562-575.

Researcher : Guan X.

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2011

Project Title:	Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011

Project Title:	Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Researcher : Guan XY

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2011

Project Title:	Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011

Project Title:	Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Researcher : Hu L

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Lin H., Hu L., Chen L., Yu H., Wang Q., Chen P., Hu X.T., Cai X.J. and Guan X., Chemically-induced cancers do not originate from bone marrow-derived cells., PLoS One. 2012, 7: e30493.

Ma N.F., Lau B.S.H., Hu L., Dong S. and Guan X., Hepatitis B virus X gene in the development of hepatocellular carcinoma. , Hong Kong Med J . 2011, 17 Suppl 6: 44-47.

Researcher : Huang Z

List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2011.

Researcher : Ip JCY

List of Research Outputs

Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Ip J.C.Y., Zabarovsky E. and Stanbridge E.J., Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago. 2012.

Researcher : Ko JMY

Project Title:	AACR Annual Meeting 2012 in Chicago, IL Application of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysis
Investigator(s):	Ko JMY
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	04/2012

Project Title:	A multigenic SNP association study of DNA repair genes on Chinese esophageal squamous cell carcinoma risk in moderate (Hong Kong) and high risk (Henan) regions
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.

Cheng Y., Cheung A.K.L., Ko J.M.Y., Phoon Y.P. and Lung M.L., Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids , American Association for Cancer Research 103rd Annual Meeting. AACR, 2012.

Ko J.M.Y., Wang L.D., Song Y.Q., Lung M.L. and Song X., Application of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysis, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Deciphering the molecular genetic basis of NPC through functional approaches, Semin Cancer Biol. 2012.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer. , In: Peter Yue Cheng , Tumor Suppressor Genes . InTech Open Access Publisher, 2011.

Lung M.L., Ko J.M.Y., Cheung W.Y. and Yu Z., Characterization of PHF11, a candidate tumor suppressor gene, in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Ip J.C.Y., Zabarovsky E. and Stanbridge E.J., Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago. 2012.

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Researcher : Kong KL

List of Research Outputs

Fan H., Chen L., Zhang F., Quan Y., Su X., Qiu X., Zhao Z., Kong K.L., Song Y., Chan H.M. and Guan X., MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. , Oncogene. 2012, 31: 2298-2308.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. , Cancer. 2012, 118: 698-710.

Researcher : Kong KL

List of Research Outputs

Researcher : Kwong DLW

Project Title:	Delineating PET active target in radiotherapy of nasopharyngeal carcinoma
Investigator(s):	Kwong DLW, Khong PL
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2010
Completion Date:	01/2012

Project Title:	ESTRO 31 IMRT for NPC
Investigator(s):	Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012
Completion Date:	05/2012

List of Research Outputs

Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary Epidemiology of Nasopharyngeal Carcinoma: A Life Course Perspective, 18th Hong Kong International Cancer Congress. 2011.

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary epidemiology of nasopharyngeal carcinoma: A life course perspective (abstract), 18th Hong Kong International Cancer Congress, 3-5 November 2011, Hong Kong. Hong Kong, Centre for Cancer Research, University of Hong Kong, 2011, 26.

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Cheng H.C., Wu V.W., Ngan K.C., Tang K.W., Chan C.C., Wong K.H., Au S.K. and Kwong D.L.W., A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients, Radiother Oncol. 2012.

Fang W.J., Xu N., Lam K.O., Ng S., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Comparison of Volumetric Evaluation for Tumor Response with RECIST for Metastatic Colorectal Cancer with Liver Metastases Only, Asian Oncology Summit 2012.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Ho C.W.A., Lee V.H.F., To V.S.H., Kwong D.L.W. and Wei W.I., Natural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patients, Oral oncology. Elsevier, 2011, 47(8): 742-6.

Huang B., Khong P.L., Kwong D.L.W., Hung B., Wong C.S. and Wong C.Y., Dynamic PET-CT studies for characterizing nasopharyngeal carcinoma metabolism: comparison of analytical methods, Nuclear Medicine Communications . 2012, 33: 191-197.

Huang B., Khong P.L., Wong C.S., Wong O.C.Y. and Kwong D.L.W., Quantitative multiparametric imaging for the evaluation of nasopharyngeal carcinoma (NPC) using FDG PET-CT and DCE-MRI, 16th Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 7-8 December, 2011.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Kwok H., Tong A.H.Y., Kwong D.L.W., Farrell P.J., Lin C., Lok S. and Chiang A.K.S., Genomic Sequencing and Comparative Analysis of Epstein-Barr Virus Genome Isolated from Primary Nascopharyngeal Carcinoma Biopsy, PLoS ONE. 2012, 7: e36939.doi:10.1371/journal.pone.0036939.

Kwong D.L.W., 1. PET/CT for IMRT Contouring in Nasopharyngeal Carcinoma 2. Setting up a Bio-Bank for Nasopharyngeal Carcinoma, Tri-society Head and Neck Oncology Meeting, 1-3 September, 2011, Singapore. 2011.

Kwong D.L.W., Advances in chemo-irradiation for oral malignancies, Head & Neck Course 2011: Common Intraoral Pathologies. 2011.

Kwong D.L.W., Darby S., McGale P., Correa C., Taylor C., Arriagada R., Clarke M., Cutter D., Davies C., Ewertz M., Godwin J., Gray R., Pierce L., Whelan T., Wang Y. and Peter R., Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials, Lancet. 2011, 378(9804): 1707-1716.

Kwong D.L.W., Effects of chemotherapy and radiotherapy on fertility, Hong Kong College of Obstetricians and Gynaecologists (HKCOG) Postgraduate Seminar. 2012.

Kwong D.L.W., IMRT for NPC, ESTRO31 (European Society for Therapeutic Radiology and Oncology Annual Scientific Meeting), Barcelona, 10-13 May, 2012 - Symposium on Head and Neck New Trials Design: Radiotherapy Techniques Requirements. 2012.

Kwong D.L.W., Non-surgical treatment: current progress in chemoradiotherapy in localized esophageal cancer , The 5th Meeting of the Society of Gastrointestinal Intervention (SGI 2011), 14-15 October, 2011, Seoul, Korean. 2011.

Kwong D.L.W., Radiation Oncology for Paediatric Oncology Patients and TBI, Post-registration certificate course in Paediatric Oncology Nursing. 2011.

Kwong D.L.W., Radiotherapy and Chemotherapy for Head and Neck Cancer, 18th ENT Course. 2012.

Kwong D.L.W., Radiotherapy for paediatric cancer, Continuous Nursing Education Program, Queen Mary Hospital. 2011.

Kwong D.L.W., Davies C., Godwin J., Gray R., Clarke M., Cutter D., Darby S., McGale P., Pan H.C., Taylor C., Wang Y.C., Dowsett M., Ingle J. and Peto R., Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials, Lancet. 2011, 378(9793): 771-784.

Lam K.O., Lee V.H.F., Choi C.W., Liu K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab After Cetuximab Failure In Kras Wild-type Metastatic Colorectal Carcinoma (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23; suppl 4: iv100; P-0248.

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Lee V.H.F., Fang W.J., Lam K.O., Choi C.W., Ng S., Ho G., Cheng T., Liu K.Y., Leung T.W., Kwong D.L.W. and Zheng S.S., Addition of Cetuximab to Oxaliplatin-based chemotherapy on Liver and Spleen Size and Thrombocytopenia in Patients with Metastatic Colorectal Cancer (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23: suppl 4: iv94; P-0224.

Lee V.H.F., Ng C.Y., Ng M.C., Ho P.P.Y., Leung T.W. and Kwong D.L.W., Change in Volumes and Radiation Doses of Parotid and Submandibular Glands during Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma., American Society for Radiation Oncology. 2011.

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Li J., Pow E.H.N., Cheung L.K., Zheng L. and Kwong D.L.W., Effects of calcium phosphate nanocrystals on osseointegration in irradiated animal., Journal of Dental Research. 2011, 90(Spec Iss B): 89.

Pow E.H.N., Kwong D.L.W., Sham J.S.T., Lee V.H.F. and Ng C.Y., Can intensity-modulated radiotherapy preserve oral-health related quality of life of nasopharyngeal carcinoma patients?, International Journal of Radiation Oncology, Biology, Physics. 2012, 83: e213-e221.

Pow E.H.N. and Kwong D.L.W., Changes of salivary function and quality of life of nasopharyngeal carcinoma patients after radiotherapy., Faculty of Dentistry, The University of Hong Kong West China College of Stomatology, Sichuan University Conjoint Scientific Meeting and Research Day of State Key Laboratory of Oral Diseases.. 2011.

Pow E.H.N., Law M.Y.T., Tsang P.C.S., Perera R.A.P.M. and Kwong D.L.W., Salivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy, Oral Oncology. 2011, 47(9): 879-882.

Pow E.H.N., Chen Z. and Kwong D.L.W., Salivary anionic changes after radiotherapy for nasopharyngeal carcinoma, Journal of Dental Research. 2012, 1219.

Pow E.H.N. and Kwong D.L.W., Salivary function and quality of life after intensity-modulated radiotherapy., Journal of Dental Research. 2011, 90(Spec Iss B): 37.

Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.

Szeto C.Y.Y., Kwong D.L.W., Lee A., Ng W.T., Lee V.H.F. and Lung M.L., Evaluation of micro-RNA biomarker panel on biopsies and non-invasive samples in nasopharyngeal carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan S.Y. and Wong K.H., Extra Free Paper Session: What is the appropriate timing for surgery after neoadjuvant chemoradiation for esophageal cancer? (Abstract), Annual Scientific Meeting 2011, The College of Surgeons of Hong Kong and Macau Surgical Association, Hong Kong, 17 - 18 September 2011.

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan S.Y. and Wong K.H., What is the appropriate timing for surgery after neoadjuvant chemoradiation for esophageal cancer, Session on "ISDS Free Papers, Esophagus 1: Malignant", (Abstract), The International Surgical Week 2011, Yokohama, Japan, 28 August - 1 September 2011.

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan S.Y. and Wong K.H., What is the appropriate timing for surgery after neoadjuvant chemoradiation for esophageal cancer?, Surgical Practice. 2011, 15(Suppl 2): B7.

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan S.Y. and Wong K.H., What is the appropriate timing for surgery after neoadjuvant chemoradiation for esophageal cancer, World Journal of Surgery. 2011, 35(Suppl 1): S172.

Tsang J.W.H., Kwong D.L.W., Beh S.L., Fielding R., Chow A.Y.M., Ho A.H.Y. and Chan L.C., We cannot love to live if we cannot bear to die: a pilot medical humanities programme for medical students to understand death, dying and bereavement., 4th Frontiers in Medical & Health Sciences Annual Meeting 2011.

Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. , Cancer. 2012, 118: 698-710.

Wong C.K.H., Lam C.L.K., Poon T.C.J., McGhee S., Law W.L., Kwong D.L.W., Tsang J.W.H. and Chan P., Direct medical costs of care for Chinese patients with colorectal neoplasia: a health care service provider perspective, Journal of Evaluation in Clinical Practice. Blackwell Publishing, 2011, 18: 1186-1195.

Wong C.K.H., Lam C.L.K., Rowen D., McGhee S., Ma K.P., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W. and Tsang J.W.H., Mapping the functional assessment of cancer therapy-general or -colorectal to SF-6D in Chinese patients with colorectal neoplasm, Value in Health. Elsevier, 2012, 15(3): 495-503.

Wong C.K.H., Lam C.L.K., McGhee S., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W., Tsang J.W.H., Rowen D.L. and Brazier J., Mapping the functional assessment of cancer therapy-general or -colorectal to preference-based values measured by SF-6D in patients with colorectal neoplasm, 18th Annual Conference of the International Society for Quality of Life Research, Denver, Colorado, USA, 28 October 2011.

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Wong K.H., Lam C.L.K., Law W.L., Poon J.T.C., Chan P., Kwong D.L.W. and Tsang J.W.H., Validity and reliability study on traditional Chinese FACT-C in Chinese patients with colorectal neoplasm., Journal of Evaluation in Clinical Practice. 2011.

Researcher : Lam KO

Project Title:	A prospective study on the predictive and prognostic value of baseline biomarker expressions in locally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine
Investigator(s):	Lam KO, Kwong DLW, Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

List of Research Outputs

Fang W.J., Xu N., Lam K.O., Ng S., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Comparison of Volumetric Evaluation for Tumor Response with RECIST for Metastatic Colorectal Cancer with Liver Metastases Only, Asian Oncology Summit 2012.

Lam K.O., Lee V.H.F., Choi C.W., Liu K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab After Cetuximab Failure In Kras Wild-type Metastatic Colorectal Carcinoma (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23; suppl 4: iv100; P-0248.

Lam K.O. and Lee V.H.F., Kras Wild-Type Metastatic Colorectal Cancer Treated with Cetuximab at First-Line, Merch Oncology Summit 2012.

Lee V.H.F., Fang W.J., Lam K.O., Choi C.W., Ng S., Ho G., Cheng T., Liu K.Y., Leung T.W., Kwong D.L.W. and Zheng S.S., Addition of Cetuximab to Oxaliplatin-based chemotherapy on Liver and Spleen Size and Thrombocytopenia in Patients with Metastatic Colorectal Cancer (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23: suppl 4: iv94; P-0224.

Researcher : Lau BSH

List of Research Outputs

Ma N.F., Lau B.S.H., Hu L., Dong S. and Guan X., Hepatitis B virus X gene in the development of hepatocellular carcinoma. , Hong Kong Med J . 2011, 17 Suppl 6: 44-47.

Researcher : Law WL

List of Research Outputs

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Researcher : Lee AWM

List of Research Outputs

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary Epidemiology of Nasopharyngeal Carcinoma: A Life Course Perspective, 18th Hong Kong International Cancer Congress. 2011.

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary epidemiology of nasopharyngeal carcinoma: A life course perspective (abstract), 18th Hong Kong International Cancer Congress, 3-5 November 2011, Hong Kong. Hong Kong, Centre for Cancer Research, University of Hong Kong, 2011, 26.

Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T., Chau J. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement, BMC Cancer. 2011, 11: 288.

Researcher : Lee VHF

Project Title:	A retrospective analysis of genetic aberrations as predictors of relapse and survival outcomes in completely resected stage III adenocarcinoma of colon after the use of oxaliplatin-based regimen as adjuvant chemotherapy
Investigator(s):	Lee VHF, Chua DTT, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2009

Project Title:	Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):	Lee VHF, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	A prospective study on the anatomical and physiological changes of carotid arteries by doppler ultrasonography after Intensity Modulated Radiation Therapy (IMRT) for untreated nasopharyngeal carcinoma (NPC)
Investigator(s):	Lee VHF, Wong CS, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

Project Title:	Host, Salivary, Virulent and Molecular Attributes to the Development of Oral Candidiasis During Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma (NPC) – A Prospective Study
Investigator(s):	Lee VHF, Seneviratne CJ, Samaranayake LP, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2012

Project Title:	Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):	Lee VHF, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

List of Research Outputs

Chan Y.W., Lee V.H.F., Chow V.L.Y., To V.S.H. and Wei W.I., Extracapsular lymph node spread in recurrent nasopharyngeal carcinoma, Laryngoscope. 2011, 121(12): 2576-2580.

Fang W.J., Xu N., Lam K.O., Ng S., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Comparison of Volumetric Evaluation for Tumor Response with RECIST for Metastatic Colorectal Cancer with Liver Metastases Only, Asian Oncology Summit 2012.

Ho C.W.A., Lee V.H.F., To V.S.H., Kwong D.L.W. and Wei W.I., Natural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patients, Oral oncology. Elsevier, 2011, 47(8): 742-6.

Lam K.O., Lee V.H.F., Choi C.W., Liu K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab After Cetuximab Failure In Kras Wild-type Metastatic Colorectal Carcinoma (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23; suppl 4: iv100; P-0248.

Lam K.O. and Lee V.H.F., Kras Wild-Type Metastatic Colorectal Cancer Treated with Cetuximab at First-Line, Merch Oncology Summit 2012.

Lee V.H.F., Fang W.J., Lam K.O., Choi C.W., Ng S., Ho G., Cheng T., Liu K.Y., Leung T.W., Kwong D.L.W. and Zheng S.S., Addition of Cetuximab to Oxaliplatin-based chemotherapy on Liver and Spleen Size and Thrombocytopenia in Patients with Metastatic Colorectal Cancer (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23: suppl 4: iv94; P-0224.

Lee V.H.F., Ng C.Y., Ng M.C., Ho P.P.Y., Leung T.W. and Kwong D.L.W., Change in Volumes and Radiation Doses of Parotid and Submandibular Glands during Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma., American Society for Radiation Oncology. 2011.

Lee V.H.F. and Chan Y.W., Chemoradiation for recurrent head and neck cancers in Head and Neck Course, Department of Surgery, The University of Hong Kong, Head and Neck Course, Department of Surgery, The University of Hong Kong. The University of Hong Kong, 2012.

Lee V.H.F., Common Cancers in Hong Kong, University Health Service, The University of Hong Kong. Hong Kong, University Health Service, The University of Hong Kong, 2011.

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Lee V.H.F., Going Through Lung Cancer, Queen Mary Hospital. 2011.

Lee V.H.F., Medical management of brain tumors, Institute of Advanced Nursing Studies, Hospital Authority. Hong Kong, Institute of Advanced Nursing Studies, Hospital Authority, 2012.

Lee V.H.F., Nasopharyngeal Cancer: signs/ symptoms, investigation, treatment & prevention , Hong Kong Anti-cancer Society. Hong Kong Anti-cancer Society, 2012.

Lee V.H.F., Palliative chemotherapy and radiotherapy for lung cancer, Macau Chest Diseases and Tuberculosis Association. 2011.

Pow E.H.N., Kwong D.L.W., Sham J.S.T., Lee V.H.F. and Ng C.Y., Can intensity-modulated radiotherapy preserve oral-health related quality of life of nasopharyngeal carcinoma patients?, International Journal of Radiation Oncology, Biology, Physics. 2012, 83: e213-e221.

Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.

Szeto C.Y.Y., Kwong D.L.W., Lee A., Ng W.T., Lee V.H.F. and Lung M.L., Evaluation of micro-RNA biomarker panel on biopsies and non-invasive samples in nasopharyngeal carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Taw B.T., Lee V.H.F., Hung K.N., Ng C.Y. and Lui W.M., The efficacy and safety of LINAC stereotactic radiosurgery booster after whole brain radiotherapy for cerebral metastases , XXth ESSFN conference in 2011.

Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T., Chau J. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement, BMC Cancer. 2011, 11: 288.

Researcher : Leung TW

List of Research Outputs

Lam K.O., Lee V.H.F., Choi C.W., Liu K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab After Cetuximab Failure In Kras Wild-type Metastatic Colorectal Carcinoma (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23; suppl 4: iv100; P-0248.

Lee V.H.F., Fang W.J., Lam K.O., Choi C.W., Ng S., Ho G., Cheng T., Liu K.Y., Leung T.W., Kwong D.L.W. and Zheng S.S., Addition of Cetuximab to Oxaliplatin-based chemotherapy on Liver and Spleen Size and Thrombocytopenia in Patients with Metastatic Colorectal Cancer (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23: suppl 4: iv94; P-0224.

Lee V.H.F., Ng C.Y., Ng M.C., Ho P.P.Y., Leung T.W. and Kwong D.L.W., Change in Volumes and Radiation Doses of Parotid and Submandibular Glands during Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma., American Society for Radiation Oncology. 2011.

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Siu S.W.K., Leung P.P.Y., Liu K.Y. and Leung T.W., Patients’ views on failure to gain expected clinical beneficial outcomes from participation in palliative medicine clinical trials, American Journal of Hospice & Palliative Medicine. 2012, online first.

Researcher : Li J

List of Research Outputs

Li J., Lau G.K., Chen L., Dong S., Lan H.Y., Huang X.R., Li Y., Luk J.M., Yuan Y.F. and Guan X., Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression, PLoS One. 2011, 6: e21816.

Researcher : Li VWK

List of Research Outputs

Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.

Researcher : Li Y

List of Research Outputs

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Kong K.L., Kwong D.L.W., Chan H.M., Law S.Y.K., Chen L., Li Y., Qin Y.R. and Guan X., MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor, Gut. 2012, 61(1): 33-42.

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Researcher : Liu KY

List of Research Outputs

Lam K.O., Lee V.H.F., Choi C.W., Liu K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab After Cetuximab Failure In Kras Wild-type Metastatic Colorectal Carcinoma (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23; suppl 4: iv100; P-0248.

Lee V.H.F., Fang W.J., Lam K.O., Choi C.W., Ng S., Ho G., Cheng T., Liu K.Y., Leung T.W., Kwong D.L.W. and Zheng S.S., Addition of Cetuximab to Oxaliplatin-based chemotherapy on Liver and Spleen Size and Thrombocytopenia in Patients with Metastatic Colorectal Cancer (Abstract), Annals of Oncology. UK, Oxford University Press, 2012, 23: suppl 4: iv94; P-0224.

Siu S.W.K., Leung P.P.Y., Liu K.Y. and Leung T.W., Patients’ views on failure to gain expected clinical beneficial outcomes from participation in palliative medicine clinical trials, American Journal of Hospice & Palliative Medicine. 2012, online first.

Wan H.Y.A., Leung P.P.Y., Liu K.Y. and Zhou P., Psychological Coping Outcomes of Chinese Breast Cancer Survivors: The Role of Trait Resilience and Cognitive Appraisals, The 18th Hong Kong International Cancer Congress, Hong Kong, 3-5 November. 2011.

Researcher : Liu M

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Researcher : Lo PHY

List of Research Outputs

Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45.

Researcher : Lu L

List of Research Outputs

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

Researcher : Lung HL

Project Title:	The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma
Investigator(s):	Lung HL, Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2009

Project Title:	The functional role of the chromosome X gene, thymosin beta 15, in nasopharyngeal carcinoma
Investigator(s):	Lung HL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	02/2012

Project Title:	Investigation of the X-linked candidate genes which escape the X-inactivation in nasopharyngeal carcinoma
Investigator(s):	Lung HL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2011.

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Deciphering the molecular genetic basis of NPC through functional approaches, Semin Cancer Biol. 2012.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer. , In: Peter Yue Cheng , Tumor Suppressor Genes . InTech Open Access Publisher, 2011.

Lung H.L., Reviewer, BMC cancer for manuscript, 2012.

Lung H.L., Cheung A.K.L., Chung Y.M., Liu E.T.B., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma (NPC), Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Ip J.C.Y., Zabarovsky E. and Stanbridge E.J., Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago. 2012.

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Researcher : Lung ML

Project Title:	Molecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	12/2011

Project Title:	Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2009

Project Title:	Centre for Nasopharyngeal Carcinoma Research
Investigator(s):	Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:	Clinical Oncology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2010

Project Title:	Role of DNAJB6 epithelial-mesenchymal transition in esophageal squamous cell carcinoma tumorigenesis and metastasis
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	AACR 103rd Annual Meeting 2012 Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	04/2012

List of Research Outputs

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary Epidemiology of Nasopharyngeal Carcinoma: A Life Course Perspective, 18th Hong Kong International Cancer Congress. 2011.

Chan Y.H., Liang J., Lung M.L., Kwong D.L.W., Lee A.W.M. and Lam T.H., Contemporary epidemiology of nasopharyngeal carcinoma: A life course perspective (abstract), 18th Hong Kong International Cancer Congress, 3-5 November 2011, Hong Kong. Hong Kong, Centre for Cancer Research, University of Hong Kong, 2011, 26.

Cheng Y., Cheung A.K.L., Ko J.M.Y., Phoon Y.P. and Lung M.L., Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids , American Association for Cancer Research 103rd Annual Meeting. AACR, 2012.

Huang Z., Cheng Y., Chiu P.M., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2011.

Ko J.M.Y., Wang L.D., Song Y.Q., Lung M.L. and Song X., Application of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysis, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272.

Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Deciphering the molecular genetic basis of NPC through functional approaches, Semin Cancer Biol. 2012.

Lung H.L., Cheung A.K.L., Ko J.M.Y., Cheng Y. and Lung M.L., Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer. , In: Peter Yue Cheng , Tumor Suppressor Genes . InTech Open Access Publisher, 2011.

Lung H.L., Cheung A.K.L., Chung Y.M., Liu E.T.B., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma (NPC), Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lung M.L., Ko J.M.Y., Cheung W.Y. and Yu Z., Characterization of PHF11, a candidate tumor suppressor gene, in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Lung M.L., Deciphering the molecular genetic basis of nasopharyngeal carcinoma through functional approaches, Guangxi, China. 2011.

Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Ip J.C.Y., Zabarovsky E. and Stanbridge E.J., Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago. 2012.

Lung M.L., NPC studies in Hong Kong, Cancer Research Institute of Zhongshan. Zhongshan, China, 2011.

Lung M.L., Tumor suppressor gene discovery in nasopharyngeal carcinoma, Croucher Advanced Study Institute, “Tumour Microenvironment – New Concepts and Molecular Mechanisms”. 2012.

Lung M.L., Unlocking the Rosetta Stone enigma for nasopharyngeal carcinoma: genetics, viral infection, and epidemiological factors, Seminars in Cancer Biology. 2012, 22: 77-78.

Szeto C.Y.Y., Kwong D.L.W., Lee A., Ng W.T., Lee V.H.F. and Lung M.L., Evaluation of micro-RNA biomarker panel on biopsies and non-invasive samples in nasopharyngeal carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012.

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Yu Z., Wong V.C.L., Chan K.W. and Lung M.L., Identification of DEC1-interacting protein DNAJB6 and its role in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Researcher : Ng CY

List of Research Outputs

Lee V.H.F., Ng C.Y., Ng M.C., Ho P.P.Y., Leung T.W. and Kwong D.L.W., Change in Volumes and Radiation Doses of Parotid and Submandibular Glands during Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma., American Society for Radiation Oncology. 2011.

Pow E.H.N., Kwong D.L.W., Sham J.S.T., Lee V.H.F. and Ng C.Y., Can intensity-modulated radiotherapy preserve oral-health related quality of life of nasopharyngeal carcinoma patients?, International Journal of Radiation Oncology, Biology, Physics. 2012, 83: e213-e221.

Taw B.T., Lee V.H.F., Hung K.N., Ng C.Y. and Lui W.M., The efficacy and safety of LINAC stereotactic radiosurgery booster after whole brain radiotherapy for cerebral metastases , XXth ESSFN conference in 2011.

Researcher : Ng WT

List of Research Outputs

Tse V.C., Ng W.T., Lee V.H.F., Lee A.W.M., Chua D.T.T., Chau J. and McGhee S., Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement, BMC Cancer. 2011, 11: 288.

Researcher : Ngan KC

List of Research Outputs

Cheng H.C., Wu V.W., Ngan K.C., Tang K.W., Chan C.C., Wong K.H., Au S.K. and Kwong D.L.W., A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients, Radiother Oncol. 2012.

Researcher : Phoon YP

List of Research Outputs

Cheng Y., Cheung A.K.L., Ko J.M.Y., Phoon Y.P. and Lung M.L., Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids , American Association for Cancer Research 103rd Annual Meeting. AACR, 2012.

Researcher : Sham JST

List of Research Outputs

Chan J.S.M., Yuen L.P., Chan H.Y., Ho T.H., Sham J.S.T. and Chan C.L.W., Effects of qigong exercise and its dose-response relationship in reducing fatigue for patients with chronic fatigue syndrome: a randomized waitlist-controlled trial., Annals of Behavioral Medicine. 2012, S282.

Ho T.H., Chan J.S.M., Wang C., Lau B.W., So K.F., Yuen L.P., Sham J.S.T. and Chan C.L.W., A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome, Ann Behav Med. 2012, Jun 27. [Epub ahead of print].

Ho T.H., Chan H.Y., Yuen L.P., Chan H.Y., Sham J.S.T. and Chan C.L.W., The long-term and anti-aging effects of qigong for the patients with chronic fatigue syndrome, Annals of Behavioral Medicine. 2012, 43 (Suppl.1): S283.

Pow E.H.N., Kwong D.L.W., Sham J.S.T., Lee V.H.F. and Ng C.Y., Can intensity-modulated radiotherapy preserve oral-health related quality of life of nasopharyngeal carcinoma patients?, International Journal of Radiation Oncology, Biology, Physics. 2012, 83: e213-e221.

Wong W., Lam C.L.K., Sham J.S.T. and Fong D.Y.T., Effectiveness of Traditional Chinese Medicine in Primary Care., In: Kuang H., Recent Advances in Theories and Practice of Chinese Medicine.. Rijeka, Croatia, In Tech, 2012, Chapter 9.

Researcher : Siu SWK

List of Research Outputs

Siu S.W.K., Leung P.P.Y., Liu K.Y. and Leung T.W., Patients’ views on failure to gain expected clinical beneficial outcomes from participation in palliative medicine clinical trials, American Journal of Hospice & Palliative Medicine. 2012, online first.

Researcher : Song Y

List of Research Outputs

Fan H., Chen L., Zhang F., Quan Y., Su X., Qiu X., Zhao Z., Kong K.L., Song Y., Chan H.M. and Guan X., MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. , Oncogene. 2012, 31: 2298-2308.

Researcher : Soong SI

List of Research Outputs

Au A.H.Y., Lam W.W.T., Tsang J.W.H., Yau T.K., Soong S.I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng A., Girgis A. and Fielding R., Support care needs in Hong Kong Chinese women confronting advanced breast cancer, Psychooncology. 2012.

Researcher : Szeto CYY

Project Title:	Critical genomic regions and mi-RNA regulation in nasopharyngeal carcinoma
Investigator(s):	Szeto CYY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

Project Title:	AACR Annual Meeting 2012 Evaluation of micro-RNA biomarker panel on biopsies and non-invasive samples in nasopharyngeal carcinoma
Investigator(s):	Szeto CYY
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	04/2012

List of Research Outputs

Szeto C.Y.Y., Kwong D.L.W., Lee A., Ng W.T., Lee V.H.F. and Lung M.L., Evaluation of micro-RNA biomarker panel on biopsies and non-invasive samples in nasopharyngeal carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Researcher : Tsang JWH

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang JWH, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2008

Project Title:	Training Oncology Interns in Patient-centred Communication
Investigator(s):	Tsang JWH, Lam WWT, Fielding R
Department:	Clinical Oncology
Source(s) of Funding:	Hong Kong Cancer Fund - General Award
Start Date:	04/2011

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang JWH, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

List of Research Outputs

Au A.H.Y., Lam W.W.T., Tsang J.W.H., Yau T.K., Soong S.I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng A., Girgis A. and Fielding R., Support care needs in Hong Kong Chinese women confronting advanced breast cancer, Psychooncology. 2012.

Au H.Y.A., Lam W.W.T., Tsang J.W.H., Yau T.K., Yau T.K., Soong I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen D.T.K., Sze W.K., Ng A., Girgis A. and Fielding R., Change patterns in supportive care needs among women diagnosed with advanced breast cancer (abstract), 18th Hong Kong International Cancer Congress, 3-5 November 2011, Hong Kong. Hong Kong, Centre for Cancer Research, University of Hong Kong, 2011, A76.

Au H.Y.A., Lam W.W.T., Tsang J.W.H., Yau T.K., Soong I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen D.T.K., Sze W.K., Ng A., Girgis A. and Fielding R., Change patterns of supportive care needs among women diagnosed with advanced breast cancer (abstract and powerpoint presentation), 18th Hong Kong International Cancer Congress, 3-5 November 2011, Hong Kong. Hong Kong, Centre for Cancer Research, University of Hong Kong, 2011.

Au H.Y.A., Lam W.W.T., Cheung O.K.Y., Tsang J.W.H., Yau T.K., Soong I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen D.T.K., Sze W.K., Ng A., Girgis A. and Fielding R., Unmet supportive care needs in Hong Kong Chinese women confronting advanced breast cancer (abstract and poster presentations), Psycho-Oncology Supplement: Abstracts for the 13th World Congress of Psycho-Oncology, 16–20 October 2011, Antalya, Turkey. 2011, 20(Suppl 2): 198-199.

Au H.Y.A., Lam W.W.T., Kwong A., Suen D.T.K., Tsang J.W.H., Yeo W., Suen J., Ho W.M., Yau T.K., Soong I., Wong K.Y., Sze W.K., Ng A., Girgis A. and Fielding R., Validation of the Chinese version of the short-form supportive Care Needs Survey Questionnaire (SCNS-SF34-C), Psycho-Oncology. 2011, 20(12): 1292-1300.

Chen J.Y. and Tsang J.W.H., Editor, In: Julie Chen (editor) Janice Tsang (co-editor), One moment in time: a photo-reflective journey from suffering to wellbeing. 2011.

Chen J.Y. and Tsang J.W.H., One moment in time - a photo reflective journey from suffering to well-being by students and staff of the Li Ka Shing Faculty of Medicine, In: Dr. Julie Chen & Dr. Janice Tsang, One moment in time - a photo reflective journey from suffering to well-being by students and staff of the Li Ka Shing Faculty of Medicine. 2011.

Chu J.P., Mak H.K.F., Yau K.K.W., Zhang L., Tsang J.W.H., Chan Q. and Leung G.K.K., Chu JP, Mak HK*, Yau KK, Zhang L, Tsang J, Chan Q, Leung KK. A pilot study on correlation of MR perfusion (Ktrans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3Tesla. Cancer Imaging , 2012, 12: 1-6.

Gradishar W., Kahan Z., Tsang J.W.H., Timcheva C., Tjulandin S., Cardoso F., Grigiene R., Iwata H., Keane M., Luebbe K., Neskovic-Konstantinovic Z., Simon S., Stemmer S.M., Vrbanec D., Arbani T., Florance A., Huang Y., Leigh M., Wroblewski S. and Johnston S., ALTERNATIVE (EGF 114299): a study of lapatinib, trastuzumab, endocrine therapy in patients who received neo/adjuvant trastuzumab and endocrine therapy., American Society of Clinical Oncology Annual Meeting 2012.

Hickish T., Tseng L.M., Mehta A., Tsang J.W.H., Kovalenko D., Udovitsa D., Pelling K., Uttenreuther-Fischer M. and Huang C.S.T., LUX-Breast 2: Phase II open label study of oral afatinib in HER2-overexpressing metastatic breast cancer patients who progressed on prior trastuzumab and.or lapatinib., American Society of Clinical Oncology Annual Meeting 2012.

Karadedou C.T., Gomes A.R., Chen J., Petkovic M., Ho K.K., Zwolinska A.K., Feltes A., Wong S.Y., Chan Y.K., Cheung Y.N., Tsang J.W.H., Brosens J.J., Khoo U.S. and Lam E.W., FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer, Oncogene. 2012, 31(14): 1845-58.

Lee V.H.F., Chan A.S.Y., Choy T.S., Tsang J.W.H., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of sequence of chemotherapy and targeted therapy for non-small cell lung cancer, Roche Asia Oncology Forum 2010. 2011.

Paik S.Y., Gong G., Yap Y.S., Kim T.Y., Cornelio G., Kim S.B., Tsang J.W.H., Kwon H.C., Ng T.Y. and Ro J., P95her2 And Pten As Supplemental Predictive Markers To Anti-her2 Therapy: Interim Analysis Of An Observational Biomarker Study , Global Breast Cancer Conference 2011.

Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.

Tsang J.W.H., Challenging Cases in Breast Cancer, Asia Pacific Oncology Conference 2011, Nanjing. 2011.

Tsang J.W.H., Clinical Utility of Genomic Profiling in Making Adjuvant Treatment Decision for Hormone Positive Node Negative Early Breast Cancer - Case Sharing, Oncotype Dx Dinner Sharing Symposium. 2012.

Tsang J.W.H., Effects of Translational Research in the last Decade: Discovery of Gene Expression Signatures Prognostication and Prediction., Global Breast Cancer Conference, Seoul, Korea, 2011. 2011.

Tsang J.W.H., Local Experience Sharing On Glioblastoma Multiforme, The Second Annual Antiangiogenesis Workshop. 2011.

Tsang J.W.H., Medical Therapeutic Options For Metastatic Renal Cell Carcinoma : Nuts And Bolts, Hong Kong Sanatorium Hospital. 2011.

Tsang J.W.H., Modern Chemotherapy, In: Dr. Janice Tsang, Modern Chemotherapy. Scientific Research Publishing, 2012.

Tsang J.W.H., Outstanding Team Award (Comprehensive Breast Oncology Care, Tung Wah Hospital) for the Hong Kong West Cluster, Hospital Authority, Hong Kong Wester Cluster, Hospital Authority. 2011.

Tsang J.W.H., Overview of Targeted Therapy , Hong Kong College of Radiologists Training Workshop. 2012.

Tsang J.W.H., Palliative Care in the Asia-Pacific Region, Asia-Pacific Organization for Cancer Prevention 6th General Assembly, Kuching, Malaysia. 2012.

Tsang J.W.H., Kwong D.L.W., Beh S.L., Fielding R., Chow A.Y.M., Ho A.H.Y. and Chan L.C., We cannot love to live if we cannot bear to die: a pilot medical humanities programme for medical students to understand death, dying and bereavement., 4th Frontiers in Medical & Health Sciences Annual Meeting 2011.

Tsang J.W.H., We cannot love to live if we cannot bear to die: a pilot medical humanities programme for medical students to understand death, dying and bereavement, Frontiers in Medical and Health Sciences Education Annual Meeting 2011: Holistic Approach in Medical and Health Sciences Education. 2011.

Tsang J.W.H., What's hot in breast cancer - from a common single disease to a rare heterogeneous disease, Hong Kong Medical Forum 2012. 2012.

Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. , Cancer. 2012, 118: 698-710.

Wong A.M.G., Guan X. and Tsang J.W.H., Response to "Potential of circulating viral microRNAs as novel biomarkers for nasopharyngeal carcinomas", Cancer. 2011.

Wong C.K.H., Lam C.L.K., Poon T.C.J., McGhee S., Law W.L., Kwong D.L.W., Tsang J.W.H. and Chan P., Direct medical costs of care for Chinese patients with colorectal neoplasia: a health care service provider perspective, Journal of Evaluation in Clinical Practice. Blackwell Publishing, 2011, 18: 1186-1195.

Wong C.K.H., Lam C.L.K., Rowen D., McGhee S., Ma K.P., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W. and Tsang J.W.H., Mapping the functional assessment of cancer therapy-general or -colorectal to SF-6D in Chinese patients with colorectal neoplasm, Value in Health. Elsevier, 2012, 15(3): 495-503.

Wong C.K.H., Lam C.L.K., McGhee S., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W., Tsang J.W.H., Rowen D.L. and Brazier J., Mapping the functional assessment of cancer therapy-general or -colorectal to preference-based values measured by SF-6D in patients with colorectal neoplasm, 18th Annual Conference of the International Society for Quality of Life Research, Denver, Colorado, USA, 28 October 2011.

Wong K.H., Lam C.L.K., Law W.L., Poon J.T.C., Chan P., Kwong D.L.W. and Tsang J.W.H., Validity and reliability study on traditional Chinese FACT-C in Chinese patients with colorectal neoplasm., Journal of Evaluation in Clinical Practice. 2011.

Wong O.L., Tsang J.W.H., Cowling B.J. and Leung G.M., Resource allocation for breast cancer prevention and care in Hong Kong: A generalized cost-effectiveness analysis (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Researcher : Wang J

List of Research Outputs

Liu M., Chen L., Chan H.M., Wang J., Li Y., Li Y., Zeng T.T., Yuan Y.F. and Guan X., Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma., Hepatology. 2012, 55: 1754-1765.

Wang J., Chen L., Li Y. and Guan X., Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. , PLoS One. 2011, 6(9): e24967.

Researcher : Wang J

List of Research Outputs

Researcher : Wong AMG

List of Research Outputs

Wong A.M.G., Kong K.L., Tsang J.W.H., Kwong D.L.W. and Guan X., Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. , Cancer. 2012, 118: 698-710.

Wong A.M.G., Guan X. and Tsang J.W.H., Response to "Potential of circulating viral microRNAs as novel biomarkers for nasopharyngeal carcinomas", Cancer. 2011.

Researcher : Wong CL

List of Research Outputs

Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.

Researcher : Wong KY

List of Research Outputs

Au A.H.Y., Lam W.W.T., Tsang J.W.H., Yau T.K., Soong S.I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng A., Girgis A. and Fielding R., Support care needs in Hong Kong Chinese women confronting advanced breast cancer, Psychooncology. 2012.

Researcher : Yau TK

List of Research Outputs

Au A.H.Y., Lam W.W.T., Tsang J.W.H., Yau T.K., Soong S.I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng A., Girgis A. and Fielding R., Support care needs in Hong Kong Chinese women confronting advanced breast cancer, Psychooncology. 2012.

Researcher : Yu Z

List of Research Outputs

Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45.

Lung M.L., Ko J.M.Y., Cheung W.Y. and Yu Z., Characterization of PHF11, a candidate tumor suppressor gene, in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Yu Z., Wong V.C.L., Chan K.W. and Lung M.L., Identification of DEC1-interacting protein DNAJB6 and its role in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.

Researcher : Yu Z

List of Research Outputs

Researcher : Zhang L

List of Research Outputs

Chen J., Fu L., Zhang L., Kwong D.L.W., Li Y. and Guan X., Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma, Chinese Journal of Cancer. 2012, 31(5): 215-222.

Fu L., Zhang C., Zhang L., Dong S., Lu L., Chen J., Dai Y., Li Y., Kong K.L., Kwong D.L.W. and Guan X., Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. , Gut. 2011, 60: 1635-1643.

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