DEPT OF PATHOLOGY



Researcher : Au LK

List of Research Outputs

Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.


Researcher : Au LKS

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.


Researcher : Beh SL

Project Title:The attitudes of doctors toward rape victims
Investigator(s):Beh SL
Department:Pathology
Source(s) of Funding:Other Funding Scheme
Start Date:06/1993


List of Research Outputs

Beh S.L., Asphyxia, In: Chen Xinshan, Forensic Medicine. China, Huazhong University of Science and Technolgy Press, 2011.
Beh S.L., Child Homicide & Child Abuse, In: Chen Xinshan, Forensic Medicine. Huazhong University of Science & Technology Press, 2011.
Beh S.L., Drowning, In: Chen Xinshan, Forensic Medicine. uazhong University of Science & Technology Press, 2011.
Beh S.L., How can education and research help to solidify and standardize forensic medicine?, 19th Triennial Meeting of The International Association of Forensic Sciences. 2011.
Beh S.L., Medical Issues Relevant To Restraint, In: Margaret M. Stark, Clinical Forensic Medicine - A Physician's Guide. New York, Dordrecht, Heideberg, London, Humana Press, 2011, 215-232.
Luk J.K.H., Liu A.N.C., Ng W.C., Beh S.L. and Chan F.H.W., End-of-life Care In Hong Kong, Asian Journal Of Gerontology & Geriatrics . 2011, 6 No. 2: 103-6.
Tsang J.W.H., Kwong D.L.W., Beh S.L., Fielding R., Chow A.Y.M., Ho A.H.Y. and Chan L.C., We cannot love to live if we cannot bear to die: a pilot medical humanities programme for medical students to understand death, dying and bereavement., 4th Frontiers in Medical & Health Sciences Annual Meeting 2011.


Researcher : Castilho AG

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.


Researcher : Chan ASY

List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Chan AYW

List of Research Outputs

Mak C.M., Lee C.Y., Lam C.W., Siu C.W.K., Hung V.C.N. and Chan A.Y.W., Personalized Medicine Switching from Insulin to Sulfonylurea in Permanent Neonatal Diabetes Mellitus Dictated by a Novel Activating ABCC8 Mutation, In: Chloe Miu Mak, Ching-yin Lee, Ching-wan LAM, Wai-Kwan Siu, Vanessa Ching-ngar Hung, Albert Yan-wo Chan, Diagnostic Molecular Pathology. 2012.


Researcher : Chan EYT

List of Research Outputs

Ho M.H.K., Aung K.P.P., Wong W.H.S., Chan E.Y.T., Lee T.L., Chong C.Y., Chow W.C., Lee P.P.W. and Lau Y.L., IgE Food Sensitization Amongst Children with Atopic Eczema, Hong Kong Journal of Paediatrics (new series). 2011, 16: 155-163.
Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.


Researcher : Chan GSW

List of Research Outputs

Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.


Researcher : Chan HY

List of Research Outputs

Zhao F., Siu M.K., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Histopathology, In: Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Chan HY, Cheung AN, Histopathology. 2011.


Researcher : Chan KW

Project Title:Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):Chan KW, Guan X
Department:Pathology
Source(s) of Funding:Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:01/2008


Project Title:The role of BARX2 in esophageal squamous cell carcinoma
Investigator(s):Chan KW
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


Project Title:The role of interleukin-8 (IL-8) and efficacy of IL-8 targeted therapy in CD133+ cancer stem cells-driven hepatocellular carcinoma
Investigator(s):Chan KW, Ma SKY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Characterization and evaluation of neuropilin-2 (NRP2) as a novel oncogene in esophageal squamous cell carcinoma (ESCC)
Investigator(s):Chan KW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.
Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.
Hui K.C., Lai K.Y., Chan K.W., Luk J.M., Lee N.P.Y., Chung Y., Cheung L.C., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Med Oncol.. 2012, [Epub ahead of print].
Hui K.C., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Cytoplasmic Forkhead Box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage, World Journal of Surgery. 2012, 36(1): 90-97.
Li B., Tsao G.S.W., Chan K.W. and Cheung A., Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis, In: Proceedings of the American Association for Cancer Research; 2012 March 31 - April 4; Chicago, IL. Philadelphia (PA): AACR. 2012, Abstract nr 4361.
Li Z., Chen J., Chan K.W., Qiao L. and Wong B.C.Y., A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Cancer Lett. 2011, 313(2): 192-200.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.
Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.
Yu Z., Wong V.C.L., Chan K.W. and Lung M.L., Identification of DEC1-interacting protein DNAJB6 and its role in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.
Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Chan KW

List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.
Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.
Hui K.C., Lai K.Y., Chan K.W., Luk J.M., Lee N.P.Y., Chung Y., Cheung L.C., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Med Oncol.. 2012, [Epub ahead of print].
Hui K.C., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Cytoplasmic Forkhead Box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage, World Journal of Surgery. 2012, 36(1): 90-97.
Li B., Tsao G.S.W., Chan K.W. and Cheung A., Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis, In: Proceedings of the American Association for Cancer Research; 2012 March 31 - April 4; Chicago, IL. Philadelphia (PA): AACR. 2012, Abstract nr 4361.
Li Z., Chen J., Chan K.W., Qiao L. and Wong B.C.Y., A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Cancer Lett. 2011, 313(2): 192-200.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.
Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.
Yu Z., Wong V.C.L., Chan K.W. and Lung M.L., Identification of DEC1-interacting protein DNAJB6 and its role in esophageal squamous cell carcinoma, Poster at 103rd Annual Meeting of American Association of Cancer Research, Chicago, USA. 2012.
Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Chan LC

Project Title:To develop a pilot humanities program in the first year undergraduate medical curriculum 2007-2008.
Investigator(s):Chan LC
Department:Pathology
Source(s) of Funding:Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:08/2007


Project Title:The 7th Asia Pacific IAP Congress 2011 Professionalism and the practice of Pathology - Key Issues and Challenges
Investigator(s):Chan LC
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2011


Project Title:King's/HKU Fellowship Awards 2011-12
Investigator(s):Chan LC
Department:Pathology
Source(s) of Funding:King's/HKU Fellowship Awards
Start Date:09/2011


List of Research Outputs

Cairns R.A., Iqbal J., Lemonnier F., Kucuk C., de Leval L., Jais J.P., Parrens M., Martin A., Xerri L., Brousset P., Chan L.C., Chan W.C., Gaulard P. and Mak T.W., IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma, Blood. 2012, 119(8): 1901-1903.
Chan L.C., Developming mindfulness in medical education – why it matters for teachers and learners , Symposium on Nurturing Lifelong Habits for Effective Future Practice: The Key to Transformative Education. 9th Asia Pacific Medical Education Conference. Singapore. 2012.
Chan L.C., Guest Speaker, The Orientation and Briefing Session for new MBS students. Centre of Buddhist Studies. The University of Hong Kong. 2011.
Chan L.C., Medical Humanities and the Development of Social Responsibility and Accountability of Health Care Professionals, 10th Anniversary Public Lecture, Universiti Tunku Abdul Rahman, Malaysia. 2012.
Chan L.C., Medical Humanities for Surgeons - A Story Worth Telling, International College of Surgeon vs Medical Education. Kiang Wu Hospital, Macau SAR. 2011.
Chan L.C., Medical Humanities, Faculty Orientation for new MBBS students, Li Ka Shing Faculty of Medicine. 2011.
Chan L.C., Peace, Religion and Health”, title: “How medical humanities and mindful practice make a better doctor, 43rd Asia Pacific Academic Consortium for Public Health Conference. Seoul, Korea. 2011.
Chan L.C., Plenary Session - Humanities in Medicine & Health Science: Medical humanities and the development of social responsibility and accountability of health care professionals, U21 Health Sciences Meeting 2011. 2011.
Chen J.Y., Chan L.K., Lam C.L.K. and Chan L.C., Medical student perception of suffering during the early clinical years, In: National University of Singapore, Singapore, 9th Asia-Pacific Medical Education Conference (APMEC). 2012.
Chen J.Y., Chan L.K., Lam C.L.K. and Chan L.C., Medical student perception of suffering during the early clinical years, In: Shortlisted for Best Oral Presentation, The 9th Asian Pacific Medical Education Conference, 11-15 January. Singapore, 2012.
Lam Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in Normal Hematopoietic Cells and Leukemic cells, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.
Lui W.C., Chan L.C. and Ng R.K., Cytokine Combinations on the Potential of ex vivo Expansion of Murine Hematopoietic Stem Cells, Days of Molecular Medicine 2011. Hong Kong.
Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Deregulation of Early Hematopoietic Genes In Mouse CD41+ Leukemia Cells Exhibiting Stem Cell Property, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.
Meyer C., Kowarz E., Yip S.F., Wan T.S.K., Chan T.K., Dingermann T., Chan L.C. and Marschalek R., A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia, Cancer Genetics . 2011, 204: 430-438.
So J.C.C., Wan T.S.K., Chow J.L., Hui K.C., Choi W.L., Lam C.C.K. and Chan L.C., A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia--evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients, Cancer Genet. 2011, 204: 430-8.
Tsang J.W.H., Kwong D.L.W., Beh S.L., Fielding R., Chow A.Y.M., Ho A.H.Y. and Chan L.C., We cannot love to live if we cannot bear to die: a pilot medical humanities programme for medical students to understand death, dying and bereavement., 4th Frontiers in Medical & Health Sciences Annual Meeting 2011.
Wong P.Y., Chen J.Y., Chan L.C. and Ho T.H., A path to bring empathy back to medical school - Mindfulness training for medical students , Frontiers in Medical and Health Sciences Education – HKU 2011 “Holistic Approaches in Medical and Health Sciences Education”. 2011.
Wong P.Y., Chen J.Y., Chan L.C. and Ho T.H., A path to bring empathy back to medical school – mindfulness training for medical students , In: The University of Hong Kong, Frontiers in Medical and Health Sciences Education. 2011.


Researcher : Chan LK

Project Title:Molecular dissection of the functional association of the PTEN and DLC1 tumor suppressors
Investigator(s):Chan LK, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


List of Research Outputs

Chan L.K., Ko F.C.F., Sze M.F., Ng I.O.L. and Yam J.W.P., Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo, PLoS ONE. 2011, 6(9): e25547.
Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.


Researcher : Chan TL

Project Title:Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):Chan TL, Leung SY, Yuen ST
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2005


Project Title:Outstanding Young Researcher Award 2007-2008
Investigator(s):Chan TL
Department:Pathology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:10/2008


Project Title:The Genome Wide Epigenetic study of Early-onset Colorectal Cancer Patients with CpG Island Methylator Phenotype (CIMP)
Investigator(s):Chan TL
Department:Pathology
Source(s) of Funding:Germany/Hong Kong Joint Research Scheme
Start Date:01/2010
Completion Date:12/2011


Project Title:AACR Annual Meeting 2012 in Chicago, Illinois Distinct Methylation Pattern in Early-Onset Colorectal Cancer Patients Without Detectable Germline Mutation
Investigator(s):Chan TL
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2012
Completion Date:04/2012


Project Title:The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):Chan TL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Chan WY

Project Title:The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract
Investigator(s):Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2011


Project Title:Neutrophil mediated host-responses during influenza A virus infection, an in vitro study
Investigator(s):Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


Project Title:Human primary lung microvascular endothelial responses to influenza A virus infection
Investigator(s):Chan WY, Nicholls JM
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Chan L.Y., Kwok H.H., Chan W.Y., Peiris J.S.M., Mak N.K., Wong R.N., Chan M.C.W. and Yue P.Y., Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis., J Ethnopharmacol.. 2011, 137(3): 1542-6.
Chan M.C.W., Chan W.Y., Tsao G.S.W. and Peiris J.S.M., Pathogenesis of SARS coronavirus infection using human lung epithelial cells: an in vitro model., Hong Kong Med J.. 2011, 17 Suppl 6: 31-5.
Chan M.C.W., Chan W.Y., Mak J.C.W., Peiris J.S.M. and Nicholls J.M., The influence of smoking on pulmonary influenza infection an ex vivo study, XIV International Symposium on Respiratory Viral Infections.. 2012.
Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.
Nicholls J.M., Chan W.Y., Li C.L., Yen H., Air G., Haslam S., Dell A., Walther T.J., Chan M.C.W. and Peiris J.S.M., Correlation of influenza infection with glycan array, The Fourth ESWI Conference, Malta.. 2011.
Nicholls J.M., Wong L.P., Chan W.Y., Poon L.L.M., So L.K.Y., Yen H., Fung K.H.Y., van Poucke S. and Peiris J.S.M., Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods., J Virol Methods.. 2012, 179(2): 409-13.
Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.
Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses. , Journal of Virology. 2011, 85 (14): 6844-6855.
Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses., J Virol. 2011, 85(14): 6844-55.


Researcher : Chan YF

List of Research Outputs

Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Deregulation of Early Hematopoietic Genes In Mouse CD41+ Leukemia Cells Exhibiting Stem Cell Property, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.


Researcher : Chan YK

Project Title:Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):Chan YK, Ng IOL, Wong CM
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010


List of Research Outputs

Cai Q., Long J., Lu W., Qu S., Wen W., Kang D., Lee J.Y., Chen K., Shen H., Shen C.Y., Sung H., Matsuo K., Haiman C.A., Khoo U.S., Ren Z., Iwasaki M., Gu K., Xiang Y.B., Choi J.Y., Park S.K., Zhang L., Hu Z., Wu P.E., Noh D.Y., Tajima K., Henderson B.E., Chan Y.K., Su F., Kasuga Y., Wang W., Cheng J.R., Yoo K.Y., Zheng H., Liu Y., Shieh Y.L., Kim S.W., Lee J.W., Iwata H., Le Marchand L., Chan S.Y., Xie X., Tsugane S., Lee M.H., Wang S., Li G., Levy S., Huang B., Shi J., Delahanty R., Zheng Y., Li C., Gao Y.T., Shu X.O. and Zheng W., Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium, Hum Mol Genet. 2011, 20(24): 4991-9.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Karadedou C.T., Gomes A.R., Chen J., Petkovic M., Ho K.K., Zwolinska A.K., Feltes A., Wong S.Y., Chan Y.K., Cheung Y.N., Tsang J.W.H., Brosens J.J., Khoo U.S. and Lam E.W., FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer, Oncogene. 2012, 31(14): 1845-58.
Liu S., Chan Y.K., Leung C.Y., Jiang L., Luk M.H.M., Lo S.T.S., Fong D.Y.T., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., HPV16 and HPV58 integrations in cervical cancer and premalignant lesions, 27th International Papillomavirus Conference, Berlin, Germany, Sept.16-22. 2011.
Yuen H.F., Zhang S.D., Wong S.Y., McCrudden C.M., Huang Y.H., Chan Y.K., El-Tanani M. and Khoo U.S., Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients", Breast Cancer Res Treat. 2012, 131(1): 351-2.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Chan YP

List of Research Outputs

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.
Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.
Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Chen SPL

List of Research Outputs

Mak C.M., Ko C.H., Lam C.W., Lau W.L., Siu C.W.K., Chen S.P.L., Law C.Y., Lai C.K., Yu C.M. and Chan A.Y., Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China, In: Mak CM, Ko CH, Lam CW, Lau WL, Siu WK, Chen SP, Law CY, Lai CK, Yu CM, Chan AY, Chin Med J (Engl). 2011, 124:2556-8.


Researcher : Chen WYW

Project Title:Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):Chen WYW
Department:Pathology
Source(s) of Funding:Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:09/2010


Project Title:Anti-tumor effects of IL2Rα (CD25) antagonists, either as single agents or in combination with a proteasome inhibitor, Bortezomib in NK-cell malignancies
Investigator(s):Chen WYW, Srivastava G
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:2011 ASH Annual Meeting and Exposition Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma
Investigator(s):Chen WYW
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:12/2011
Completion Date:12/2011


List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.


Researcher : Cheng HWG

List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Cheung ANY

Project Title:Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:Pathology
Source(s) of Funding:Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:02/2005


Project Title:Folate and folate receptor alpha in ovarian cancers
Investigator(s):Cheung ANY, Siu KY
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2007


Project Title:Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):Cheung ANY, Ngan HYS, Siu KY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2007


Project Title:Cervical cancer screening by enhanced cervical cytology-application of novel markers
Investigator(s):Cheung ANY, Ngan HYS, Guan X
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2007


Project Title:Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):Cheung ANY
Department:Pathology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2008


Project Title:Tropomyosin-related kinase B and Brain-derived neurotrophic factor in ovarian cancer
Investigator(s):Cheung ANY, Siu KY, Ngan HYS
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2008


Project Title:FBI-1 in ovarian carcinogenesis and progression
Investigator(s):Cheung ANY, Siu KY, Ngan HYS
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2009


Project Title:HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):Cheung ANY
Department:Pathology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2009


Project Title:Hedgehog pathway regulator Kif7 in gestational trophoblastic disease
Investigator(s):Cheung ANY, Ngan HYS, Siu KY, Wong GW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2010
Completion Date:02/2012


Project Title:DOCK180 in ovarian cancer progression
Investigator(s):Cheung ANY, Siu KY
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2011
Completion Date:12/2012


Project Title:XVITH WORLD CONGRESS ON GESTATIONAL TROPHOBLASTIC DISEASES p21-activated kinase signaling in Gestational Trophoblastic Diseases
Investigator(s):Cheung ANY
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:10/2011


Project Title:p21-activated kinase 4 in chemosensitivity of ovarian cancer
Investigator(s):Cheung ANY, Ngan HYS, Wong GW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2012


Project Title:FBI-1 (Pokemon) in Gestational Trophoblastic Disease
Investigator(s):Cheung ANY, Ngan HYS, Siu KY, Wong GW
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Tumour Microenvironment - New concepts and molecular mechanisms
Investigator(s):Cheung ANY, Ng IOL, Khoo US, Lung ML, Ngan HYS
Department:Pathology
Source(s) of Funding:Croucher Advanced Study Institute
Start Date:01/2012


Project Title:HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):Cheung ANY, Ngan HYS
Department:Pathology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2012


List of Research Outputs

Chan D.W., Liu V.W.S., Leung L.Y., Yao K.M., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells, J Pathol. 2011, 225(4): 525-34.
Cheung A.N.Y., 1. Cervical cancer screening in Hong Kong 2. Molecular methods in non-gynaecological cytology, Invited speaker in International Academy Cytology Tutorials, Hong Kong on February 24-27, 2012. 2012.
Cheung A.N.Y., A multi-center and multi-national retrospective study on the prognostic factors of sarcoma of uterus., Invited presentation on a trial in 2nd Asian Gynecologic Oncology Group (AGOG) Board Meeting and General Assembly and Annual Meeting, 3-4 Nov 2011, Seoul, Korea. 2011.
Cheung A.N.Y., Recent Advances on Clinical Cytology, CMAM, Associacao Chinesa does Profissionais de Medicina de Macau, Macau, July 10, 2011. 2011.
Cheung A.N.Y., Recent advances and Quality Assurance in cervical cytology, Invited plenary speaker in the 9th Annual Meeting of Chinese Society of Cytopathology, Changchun, August 27-28, 2011. 2011.
Cheung A.N.Y., Updates on Pathology of Uterine Sarcoma, Invited speaker in 2nd Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO), 3-5 Nov 2011, Seoul, Korea. 2011.
Cheung A.N.Y., p21-activated kinase signalling in Gestational Trophoblastic Diseases, Chairperson and Invited speaker in XVI World Congress on Gestational Trophoblastic Diseases, Budapest, 16-19 Oct, 2011. 2011.
Cheung P.F.Y., Cheng C.K.C., Wong C.L., Ho J.C.Y., Yip C.W., Lui V.C.H., Cheung A.N.Y., Fan S.T. and Cheung S.T., Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells, PLoS One. 2011, 6(12): e28246.
Fung K.C.F., Chan D.W., Liu V.W.S., Leung T.H.Y., Cheung A.N.Y. and Ngan H.Y.S., Increased expression of PITX2 transcription factor contributes to ovarian cancer progression, PLos One. PLos, 2012, 7: e37076.
Ip P.P.C. and Cheung A.N.Y., Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential, In: Ip PP, Cheung AN, Best Pract Res Clin Obstet Gynaecol. 2011.
Jiang L., Siu M.K., Wong O.G., Tam K.F., Lu X., Lam E.W., Ngan H.Y.S., Le X.F., Wong E.S., Monteiro L.J., Chan H.Y. and Cheung A.N.Y., iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe, Clinical Cancer Research. 2011, 17(21): 6924-33.
Kodithuwakkul S.P., Pang R.T.K., Ng E.H.Y., Cheung A.N.Y., Horne A.W., Ho P.C., Yeung W.S.B. and Lee C.K.F., Wnt activation downregulates Olfactomedin-1 (Olfm-1) in Fallopian tubal epithelial cells: an microenvironment predisposed to tubal ectopic pregnancy, Laboratory Investigation . 2012, 92: 256-264.
Leung O.N., Pang R.T.K., Ye T., Cheung A.N.Y. and Yeung W.S.B., MiR-135a involves in the formation of tumor-initiating cells in cervical cancer. , The Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual scientific meeting, 6 November 2011, Hong Kong. 2011.
Leung T.H.Y., Chan K.K.L., Chan D.W., Cheung A.N.Y. and Ngan H.Y.S., Indetification and characterization of cancer stem-like cells in cervical cancer, , Asia-Oceania Research Organization in Genital Infection and Neoplasia (AOGIN) 2012, Hong Kong. 2012.
Leung T.H.Y., Wong S.C.S., Chan K.K.L., Chan D.W., Cheung A.N.Y. and Ngan H.Y.S., Significance of p73 in the sensitivity of cancer treatment in gynaecological cancers, Tumor Microenvironment-New Concepts and Molecular Mechanisms, Croucher Advanced Study Institute 2012, Hong Kong. 2012.
Leung T.W., Liu S., Cheung A.N.Y. and Ngan H.Y.S., Methylation at HPV18 E2 binding sites increases during cervical carcinogenesis, 27th International Papillomavirus Conference, Berlin, Germany, Sept.16-22. 2011.
Liao S., Li R.H.W., Ho J.C.M., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy, Journal of Clinical Endocrinology and Metabolism . Journal of Clinical Endocrinolog and Metabolism, 2012, 97: 2105-2112.
Liu S., Chan Y.K., Leung C.Y., Jiang L., Luk M.H.M., Lo S.T.S., Fong D.Y.T., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., HPV16 and HPV58 integrations in cervical cancer and premalignant lesions, 27th International Papillomavirus Conference, Berlin, Germany, Sept.16-22. 2011.
Ngan H.Y.S., Liu S., Leung C.Y. and Cheung A.N.Y., Association between DeltaNp73 expression and HPV infection in cervical cancer, 27th International Papillomavirus Conference, Berlin, Germany, Sept.16-22, . 2011.
O W.S., Liao S., Li R.H.W., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., The role of adrenomedullin in tubal ectopic pregnancy, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 81 Abstract 124.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of GenoFlow HPV test and Linear Array in an Asian Screening Population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of HPV test in evaluation of atypical squamous cells of undetermined significance from Asian screening population, Scientific seminar of Hong Kong Society for Molecular Diagnostic Sciences Limited. 香港分子生物診斷學會, 2011.
Wong G.W., Jiang L. and Cheung A.N.Y., iASPP and Chemoresistance in Ovarian Cancers–Paclitaxel-Mediated Mitotic Catastrophe and Apoptosis, Croucher Advanced Study Institute 2012 Tumour Microenvironment - New Concepts and Molecular Mechanisms. 2012.
Xue W.C. and Cheung A.N.Y., Endometrial stromal sarcoma of uterus, In: Xue WC, Cheung AN, Best Pract Res Clin Obstet Gynaecol. 2011.
Zhao F., Siu M.K., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Histopathology, In: Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Chan HY, Cheung AN, Histopathology. 2011.


Researcher : Cheung CH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Lee K.W., Cheung C.H. and Ng I.O.L., Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma. , Cancer letters. 2012.


Researcher : Cheung CH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Lee K.W., Cheung C.H. and Ng I.O.L., Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma. , Cancer letters. 2012.


Researcher : Cheung KW

Project Title:Effect of HIV-1 infected gut mucosa-type monocyte/macrophage on CD4 T cell fate
Investigator(s):Cheung KW, Chen Z
Department:Medical Faculty
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.


Researcher : Cheung YN

Project Title:Examination of eIF4E level in human breast cancers and study the role of eIF4E in regulating translation of various splice variants of breast cancer genes
Investigator(s):Cheung YN, Khoo US, Chan YK
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2010


Project Title:AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):Cheung YN
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2010


List of Research Outputs

Karadedou C.T., Gomes A.R., Chen J., Petkovic M., Ho K.K., Zwolinska A.K., Feltes A., Wong S.Y., Chan Y.K., Cheung Y.N., Tsang J.W.H., Brosens J.J., Khoo U.S. and Lam E.W., FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer, Oncogene. 2012, 31(14): 1845-58.


Researcher : Ching YP

Project Title:Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):Ching YP, Ng IOL, Jin D, Yau TO
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2006


Project Title:The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease
Investigator(s):Ching YP
Department:Anatomy
Source(s) of Funding:Travel Grants for NSFC/RGC JRS
Start Date:12/2007


Project Title:The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease
Investigator(s):Ching YP, Jin D
Department:Anatomy
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2009
Completion Date:12/2011


Project Title:Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):Ching YP, Jin D
Department:Anatomy
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development
Investigator(s):Ching YP
Department:Anatomy
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Characterisation of the roles of LKB1 in liver cancer formation
Investigator(s):Ching YP
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:03/2012


Project Title:A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer
Investigator(s):Ching YP
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Regulation of p53 by PAK4 in hepatocellular carcinoma
Investigator(s):Ching YP
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012




Researcher : Choi WL

Project Title:Retrospective study on prevalence and prognostic significance of c-kit mutation in AML1-ETO acute myeloid leukemia (AML)
Investigator(s):Choi WL, So JCC, Chan LC, Leung AYH
Department:Pathology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:10/2008


Project Title:Postgraduate Studentship (PGS) using a Type B RPg place for the purpose of admission of a newly registered full-time MPhil
Investigator(s):Choi WL
Department:Pathology
Source(s) of Funding:School of Professional and Continuing Education - General Award
Start Date:09/2009


Project Title:The Effects of DNA Methylation Signature in t(8;21) Acute Myeloid Leukaemia Cells on Patient Outcome
Investigator(s):Choi WL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:09/2010
Completion Date:08/2011


Project Title:Investigation of the incidence and prognostic impact of common genetic mutations in acute myeloid leukaemia of local patients
Investigator(s):Choi WL, Chan LC
Department:Pathology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:02/2011


Project Title:Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:Pathology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:04/2011


Project Title:Identification of FOXP1 target genes in diffuse large B-cell lymphoma
Investigator(s):Choi WL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2012


List of Research Outputs

Au W.Y., Wai-Hung L., Wong K.Y. and Choi W.L., Concomitant plasmacytoma and B cell lymphoma with discordant light chain expression but clonal identity, Ann Hematol. 2012, 91: 1649-51.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Love C.L., Jima D., Zhang J., Grubor V., Miles R.R., Dunphy C.H., Richards K.L., Choi W.L., Au W.Y., Srivastava G., Chadburn A., Gordon L.I., Evens A.M., Hsi E.D., Czader M., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Sunay S., Flowers C.R., Naresh K., Thompson M.A., Gill J. and Dave S.S., Whole genome and exome sequencing reveals the genetic landscape of Burkitt lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.
Perpinan D., Costa T.P., Choi W.L., Caponetti G., Brodersen B.W. and Armstrong D.L., Clinical and pathologic characteristics of T-cell lymphoma with a leukemic phase in a raccoon dog (Nyctereutes Procyonoides), J Vet Diagn Invest. 2011, 23: 817-20.
So J.C.C., Wan T.S.K., Chow J.L., Hui K.C., Choi W.L., Lam C.C.K. and Chan L.C., A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia--evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients, Cancer Genet. 2011, 204: 430-8.
Visco C., Li Y., Xu-Monette Z.Y., Miranda R.N., Green T.M., Tzankov A., Wen W., Liu W.M., Kahl B.S., d'Amore E.S., Montes-Moreno S., Dybkaer K., Chiu A., Tam W., Orazi A., Zu Y., Bhagat G., Winter J.N., Wang H.Y., O'Neill S., Dunphy C.H., Hsi E.D., Zhao X.F., Go R.S., Choi W.L., Zhou F., Czader M., Tong J., Zhao X., van Krieken J.H., Huang Q., Ai W., Etzell J., Ponzoni M., Ferreri A.J., Piris M.A., Moller M.B., Bueso-Ramos C.E., Medeiros L.J., Wu L. and Young K.H., Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study, Leukemia. 2012, 26: 2103-13.
Visco C., Tzankov A., Xu-Monette Z.Y., Miranda R.N., d'Amore E.S.G., Montes-Moreno S., Dybkae K., Chiu A., Tam W., Orazi A., Zu Y., Bhagat G., Kahl B.S., Winter J.N., Wang H.-.Y., Dunphy C.H., Hsi E.D., Zhao F.X., Go R.S., Choi W.L., Zhou F., Czader M., Zhao X., Van Krieken J.H.J.M., Huang Q., Ai W., Etzell J.E., Ponzoni M., Ferreri A.J.M., Piris M.A., Møller M.B., Bueso-Ramos C.E., Medeiros L.J. and Young K.H., The t(14;18)(q32;q21) characterizes a subset of patients with diffuse large-B Cell lymphoma of germinal center origin with poor outcome: report from the International DLBCL Rituximab-CHOP Consortium Program Study, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Miezcowski P., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D.D., Luftig M., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B. and Dave S.S., The genetic landscape of immune-competent and HIV lymphoma, 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). 2012.


Researcher : Chow NK

List of Research Outputs

Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.


Researcher : Chu KY

List of Research Outputs

Sze M.F., Chu K.Y. and Ng I.O.L., C-terminus-truncated hepatitis B virus X protein enhances cell invasiveness in hepatocellular carcinoma, 103rd Annual Meeting of the American Association for Cancer Research, Chicago, USA, March 31-April 04. 2012. . 2012.


Researcher : Chung LP

List of Research Outputs

Lam C.L.D., Girard L., Beer D.G., Gerald W.L., Kris M., Sihoe A.D.L., Cheng L.C., Wong M.P., Chung L.P., Ip M.S.M., Lam W.K., Gazdar A.F., Wistuba I.I. and Minna J.D., Expression of LATS2 and STK17B distinguishes epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 from those in 18 and 20 in lung adenocarcinomas, World Congress of Lung Cancer 2011.


Researcher : Deng J

List of Research Outputs

Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Fan NY

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.


Researcher : Fung KHY

List of Research Outputs

Nicholls J.M., Wong L.P., Chan W.Y., Poon L.L.M., So L.K.Y., Yen H., Fung K.H.Y., van Poucke S. and Peiris J.S.M., Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods., J Virol Methods.. 2012, 179(2): 409-13.


Researcher : Guo T

List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.


Researcher : Ha SY

List of Research Outputs

Cheung Y.F., Chan G.C.F., Au W.Y., Lam W.W.M., Cheung W.W.W., Ho Y.C., Wong S.J. and Ha S.Y., Left ventricular torsional mechanics remains impaired in patients with beta-thalassaemia major despite bone marrow transplanation, American Heart Association Scientifice Sessions 2011, Orlando, Florida, USA 2011.


Researcher : Ho RSL

List of Research Outputs

Ho R.S.L., Chan G.C.F., Ha S.Y. and Ip P.P.C., Endometriosis associated serous borderline tumor and endometrial stromal sarcoma of the ovary: Report of a rare lesion in an infant, International Journal of Gynecological Pathology. 2012, 31(1): 98-102.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Ip PPC

List of Research Outputs

Ho R.S.L., Chan G.C.F., Ha S.Y. and Ip P.P.C., Endometriosis associated serous borderline tumor and endometrial stromal sarcoma of the ovary: Report of a rare lesion in an infant, International Journal of Gynecological Pathology. 2012, 31(1): 98-102.
Ip P.P.C. and Cheung A.N.Y., Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential, In: Ip PP, Cheung AN, Best Pract Res Clin Obstet Gynaecol. 2011.
Seto W.K., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.


Researcher : Ip YC

Project Title:Targeting Granulin for Breast Cancer Therapy
Investigator(s):Ip YC, Khoo US
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2008




Researcher : Jiang L

List of Research Outputs

Liu S., Chan Y.K., Leung C.Y., Jiang L., Luk M.H.M., Lo S.T.S., Fong D.Y.T., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., HPV16 and HPV58 integrations in cervical cancer and premalignant lesions, 27th International Papillomavirus Conference, Berlin, Germany, Sept.16-22. 2011.
Wong G.W., Jiang L. and Cheung A.N.Y., iASPP and Chemoresistance in Ovarian Cancers–Paclitaxel-Mediated Mitotic Catastrophe and Apoptosis, Croucher Advanced Study Institute 2012 Tumour Microenvironment - New Concepts and Molecular Mechanisms. 2012.


Researcher : Kan J

Project Title:The possible role and function of a histone H3K4 demethylase, JARID1B in defining colorectal cancer stem cells
Investigator(s):Kan J, Leung SY
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2011
Completion Date:09/2012


List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Khoo US

Project Title:Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):Khoo US, Cheung ANY, Chan YK
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):Khoo US
Department:Pathology
Source(s) of Funding:CGDN NCE Large Scale Collaborative Research Grant
Start Date:02/2005


Project Title:Promoter polymorphisms of L-SIGN in relation to host genetic susceptibility to SARS.
Investigator(s):Khoo US, Chan YK
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2006


Project Title:Splice variant expression in relation to Estrogen Receptor gene expression in Chinese breast cancer
Investigator(s):Khoo US, Chan YK, Kwong A
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2007


Project Title:Ubiquitination of Estrogen Receptor-alpha (ESR1) isoforms
Investigator(s):Khoo US, Chan YK
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2007


Project Title:The role of FOXO transcription factors in the development of hormone refractory breast cancer
Investigator(s):Khoo US, Chan YK, Ip YC
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2009


Project Title:A pre-neoplastic marker for basal-like breast cancer
Investigator(s):Khoo US, Chan YK
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2010


Project Title:HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:Pathology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Characterization of candidate microRNAs associated with Tamoxifen resistance in breast cancer
Investigator(s):Khoo US, Cheung YN
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


Project Title:The role of eIF4E in regulating translation of splice variants of breast cancer related genes
Investigator(s):Khoo US
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Cai Q., Long J., Lu W., Qu S., Wen W., Kang D., Lee J.Y., Chen K., Shen H., Shen C.Y., Sung H., Matsuo K., Haiman C.A., Khoo U.S., Ren Z., Iwasaki M., Gu K., Xiang Y.B., Choi J.Y., Park S.K., Zhang L., Hu Z., Wu P.E., Noh D.Y., Tajima K., Henderson B.E., Chan Y.K., Su F., Kasuga Y., Wang W., Cheng J.R., Yoo K.Y., Zheng H., Liu Y., Shieh Y.L., Kim S.W., Lee J.W., Iwata H., Le Marchand L., Chan S.Y., Xie X., Tsugane S., Lee M.H., Wang S., Li G., Levy S., Huang B., Shi J., Delahanty R., Zheng Y., Li C., Gao Y.T., Shu X.O. and Zheng W., Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium, Hum Mol Genet. 2011, 20(24): 4991-9.
Karadedou C.T., Gomes A.R., Chen J., Petkovic M., Ho K.K., Zwolinska A.K., Feltes A., Wong S.Y., Chan Y.K., Cheung Y.N., Tsang J.W.H., Brosens J.J., Khoo U.S. and Lam E.W., FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer, Oncogene. 2012, 31(14): 1845-58.
Long J., Cai Q., Sung H., Shi J., Zhang B., Choi J.Y., Wen W., Delahanty R.J., Lu W., Gao Y.T., Shen H., Park S.K., Chen K., Shen C.Y., Ren Z., Haiman C.A., Matsuo K., Kim M.K., Khoo U.S., Iwasaki M., Zheng Y., Xiang Y.B., Gu K., Rothman N., Wang W., Hu Z., Liu Y., Yoo K.Y., Noh D.Y., Han B.G., Lee M.H., Zheng H., Zhang L., Wu P.E., Shieh Y.L., Chan S.Y., Wang S., Xie X., Kim S.W., Henderson B.E., Le Marchand L., Ito H., Kasuga Y., Ahn S.H., Kang H.S., Chan Y.K., Iwata H., Tsugane S., Li C., Shu X.O., Kang D.H. and Zheng W., Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer, PLoS Genet. 2012, 8(2): e1002532.
Wong C.C.L., Gilkes D.M., Zhang H., Chen J., Wei H., Chaturvedi P., Fraley S.I., Wong C.M., Khoo U.S., Ng I.O.L., Wirtz D. and Semenza G.L., Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation, Proc Natl Acad Sci U S A. 2011, 108(39): 16369-74.
Yuen H.F., Zhang S.D., Wong S.Y., McCrudden C.M., Huang Y.H., Chan Y.K., El-Tanani M. and Khoo U.S., Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients", Breast Cancer Res Treat. 2012, 131(1): 351-2.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Ko FCF

Project Title:AACR 103rd Annual Meeting 2012 cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis
Investigator(s):Ko FCF
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2012
Completion Date:04/2012


Project Title:Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):Ko FCF, Yam JWP
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chan L.K., Ko F.C.F., Sze M.F., Ng I.O.L. and Yam J.W.P., Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo, PLoS ONE. 2011, 6(9): e25547.
Chen L., Liu C., Ko F.C.F., Xu N., Ng I.O.L., Yam J.W.P. and Zhu G., Solution structure of the PTB domain of human Tensin2 in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode, Journal of Biological Chemistry. 2012, 287(31): 26104-26114.
Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.


Researcher : Ko KH

List of Research Outputs

Wang S., Shi Y., Yang M., Ma J., Tian J., Chen J., Mao C., Jiao Z., Ko K.H., Baidoo S.E., Xu H., Hua Z. and Lu L., Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells, Am J Pathol. 2012, 180(3): 1059-67.
Wang X., Chan C.C., Yang M., Deng J., Poon V.K., Leung V.H., Ko K.H., Zhou J., Yuen K.Y., Zheng B.J. and Lu L., A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection, Cell Mol Immunol. 2011, 8(6): 462-8.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Kwan PS

List of Research Outputs

Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.


Researcher : Kwok JSY

List of Research Outputs

Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.


Researcher : Lai JCC

List of Research Outputs

Lai J.C.C., Garcia J.C., Dyason J.C., Böhm R., Madge P.D., Rose F.J., Nicholls J.M., Peiris J.S.M., Haselhorst T. and von Itzstein M., A secondary sialic acid binding site on influenza virus neuraminidase. Fact or fiction?, Angew Chem Int Ed Engl. . 2012, 51: 2221-4.


Researcher : Lam CCK

List of Research Outputs

Liu A.P.Y., So J.C.C., Lam C.C.K., Ha S.Y., Chan G.C.F. and Chung B.H.Y., Clinical Quiz: What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). 2011, 16: 292.
So J.C.C., Wan T.S.K., Chow J.L., Hui K.C., Choi W.L., Lam C.C.K. and Chan L.C., A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia--evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients, Cancer Genet. 2011, 204: 430-8.


Researcher : Lam CW

Project Title:Whole genome scan of genetic susceptibility for hepatitis B carries
Investigator(s):Lam CW
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2006


Project Title:Therapeutic antibodies against basal cell carcinomas of the skin
Investigator(s):Lam CW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2009


Project Title:Molecular basis of autism spectrum disorders in Chinese
Investigator(s):Lam CW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010


Project Title:Clinical Biomonitoring of Environmental Chemicals
Investigator(s):Lam CW
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2011
Completion Date:12/2012


List of Research Outputs

Cheung K.T., Leung A.Y.M., Chan S.S.C., Lie Ken Jie M.S.F., Chan F.H.W. and Lam C.W., Health Literacy, Knowledge in Vitamin D and Sunlight Exposure: A Cross-sectional Survey in Residential Care Homes, 16th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, December 7 & 8, 2011 . Hong Kong, 2011.
Lam C.W., Advances in Mass Spectrometry Symposium 2011, 25 Oct 2011, LKS Faculty of Medicine, The University of Hong Kong. 2011.
Lam C.W., Allied Health Committee of Pathology Commissioned Training Program 2011/12, 10-11 November 2011. 2011.
Lam C.W., Associate Editor, Clinical and Translational Medicine 2012. 2012.
Lam C.W., Invited speaker at the simultaneous session “Project development and promotion in translational medicine”, 2012 Sino-American Symposium on Clinical and Translational Medicine, 27-29 June 2012, Shanghai International Convention Centre, Shanghai, China. 2012.
Lam C.W., Microarrays for Genomic Medicine: Omics-based Medicine and Systems Pathology, Recent Advances in Genomics with Applications in Medicine Inaugural HKU-McGill Symposium, 3-4 May 2012, Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012.
Lam C.W., Proficiency Testing in Clinical Toxicology, International Symposium on Food and Health - from Measurement Science to Quality and Safety, 10 November 2011, Hotel Nikko Hongkong, Hong Kong. 2011.
Lam C.W., Recent Advances in the Genetic Basis of Autism, CRDG Symposium in Autism, 31 March - 1 April 2012, Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong . 2012.
Lam C.W., Symposium Lecture "DNA-based diagnosis of endocrine disease", Annual Scientific Meeting & Annual General Meeting Hong Kong Society of Endocrinology, Metabolism and Reproduction (6th November 2011). 2011.
Lee H.H.C., Lai C.K., Yau K.C., Siu T.S., Mak C.M., Yuen Y.P., Chan K.Y., Tam S., Lam C.W. and Chan A.Y., Non-invasive urinary screening for aromatic L-amino acid decarboxylase deficiency in high-prevalence areas: a pilot study, In: Lee HC, Lai CK, Yau KC, Siu TS, Mak CM, Yuen YP, Chan KY, Tam S, Lam CW, Chan AY, Clin Chim Acta. 2012, 413:126-30.
Leung A.Y.M., Cheung K.T., Chan S.S.C., Lie Ken Jie M.S.F., Chan F. and Lam C.W., Vitamin D deficiency in Hong Kong residential care homes for elderly: An explorative study., 8th World Congress on Long Term Care in Chinese Communities and Asian Ageing Development Conference. Hong Kong, 2011.
Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.
Mak C.M., Lee C.Y., Lam C.W., Siu C.W.K., Hung V.C.N. and Chan A.Y.W., Personalized Medicine Switching from Insulin to Sulfonylurea in Permanent Neonatal Diabetes Mellitus Dictated by a Novel Activating ABCC8 Mutation, In: Chloe Miu Mak, Ching-yin Lee, Ching-wan LAM, Wai-Kwan Siu, Vanessa Ching-ngar Hung, Albert Yan-wo Chan, Diagnostic Molecular Pathology. 2012.
Mak C.M., Ko C.H., Lam C.W., Lau W.L., Siu C.W.K., Chen S.P.L., Law C.Y., Lai C.K., Yu C.M. and Chan A.Y., Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China, In: Mak CM, Ko CH, Lam CW, Lau WL, Siu WK, Chen SP, Law CY, Lai CK, Yu CM, Chan AY, Chin Med J (Engl). 2011, 124:2556-8.
Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.
Wu J., Leung K.F., Tong S.F. and Lam C.W., Organochlorine isotopic pattern‐enhanced detection and quantification of triclosan and its metabolites in human serum by ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight/mass spectrometry, In: Jian‐lin Wu, Ka‐Fai Leung, Sui‐Fan Tong, Ching‐Wan Lam, Rapid Communications in Mass Spectrometry. 2012.
Zha Y., Chen X.M., Lam C.W., Lee S.C., Tong S.F. and Gao Z.Q., Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients, In: Zha Y, Chen XM, Lam CW, Lee SC, Tong SF, Gao ZQ, Laryngoscope. 2011, 121:1760-4.


Researcher : Lam YM

List of Research Outputs

Lam Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in Normal Hematopoietic Cells and Leukemic cells, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.


Researcher : Lau WH

List of Research Outputs

Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.


Researcher : Law CY

List of Research Outputs

Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.
Mak C.M., Ko C.H., Lam C.W., Lau W.L., Siu C.W.K., Chen S.P.L., Law C.Y., Lai C.K., Yu C.M. and Chan A.Y., Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China, In: Mak CM, Ko CH, Lam CW, Lau WL, Siu WK, Chen SP, Law CY, Lai CK, Yu CM, Chan AY, Chin Med J (Engl). 2011, 124:2556-8.
Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.


Researcher : Lee HHC

List of Research Outputs

Lee H.H.C., Lai C.K., Yau K.C., Siu T.S., Mak C.M., Yuen Y.P., Chan K.Y., Tam S., Lam C.W. and Chan A.Y., Non-invasive urinary screening for aromatic L-amino acid decarboxylase deficiency in high-prevalence areas: a pilot study, In: Lee HC, Lai CK, Yau KC, Siu TS, Mak CM, Yuen YP, Chan KY, Tam S, Lam CW, Chan AY, Clin Chim Acta. 2012, 413:126-30.
Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.


Researcher : Lee KW

Project Title:The significance of nucleophosmin phosphorylation (Threonine 234) in HCC metastasis
Investigator(s):Lee KW, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010
Completion Date:01/2012


Project Title:Clinical relevance and functional characterization of NEDD9 in hepatocellular carcinoma
Investigator(s):Lee KW, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2011


Project Title:The significance of Nucleophosmin (NPM) phosphorylation in the progression of hepatocellular carcinoma
Investigator(s):Lee KW, Wong CM
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


Project Title:Clinical relevance and functional characterization of CD47 in hepatocellular carcinoma
Investigator(s):Lee KW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


Project Title:Cold Spring Harbor Asia Conferences - Liver Metabolism, Diseases & Cancer Identification of CD47 as a novel therapeutic target for hepatocellular carcinoma
Investigator(s):Lee KW
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Lee K.W., Journal of Liver: Disease & Transplantation . 2012.
Lee K.W., Cheung C.H. and Ng I.O.L., Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma. , Cancer letters. 2012.
Shao Y., Li C., Ma Y.Y., Liu X., Ling C., Yeung W.H., Lee K.W., Fan S.T., Lo C.M. and Man K., The role of regulatory B cells during the progression of human hepatocellular carcinoma, Immunology 2012 Conference, Boston, Massachusetts, U.S.A., 4 - 8 May 2012. Journal of Immunology. 2012, 188(Suppl): 162.39.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.
Yau W.L., Pang R.W.C., Lee K.W., Lam C.S.C., Wo Y.H., Ng L., Chan J.Y.K., Chow A.K.M., Ng K.T.P., Man K. and Poon R.T.P., Overexpression of miR106b promotes metastasis in hepatocellular carcinoma by activating epithelial mesenchymal transition process, The 18th Hong Kong International Cancer Congress, Hong Kong, 3 - 5 November 2011.
Yeung W.H., Lee K.W., Geng W., Li C., Ng K.T.P., Lo C.M., Guan X., Poon R.T.P., Fan S.T. and Man K., M2 macrophages promotes tumor growth and invasion in hepatocellular carcinoma, The 18th Annual International Congress of the International Liver Transplantation Society, San Francisco, California, U.S.A., 16 - 19 May 2012.


Researcher : Lee MF

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781.
Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012.
Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.


Researcher : Lee SP

List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Lee SP

List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Leung KF

List of Research Outputs

Wu J., Leung K.F., Tong S.F. and Lam C.W., Organochlorine isotopic pattern‐enhanced detection and quantification of triclosan and its metabolites in human serum by ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight/mass spectrometry, In: Jian‐lin Wu, Ka‐Fai Leung, Sui‐Fan Tong, Ching‐Wan Lam, Rapid Communications in Mass Spectrometry. 2012.


Researcher : Leung SY

Project Title:Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):Leung SY, Yuen ST
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):Leung SY, Yuen ST
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2005


Project Title:Genomics, genetics and clinico-pathological study of gastrointestinal cancers
Investigator(s):Leung SY
Department:Pathology
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:07/2007


Project Title:Research Output Prize (Faculty of Medicine)
Investigator(s):Leung SY
Department:Pathology
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:11/2007


Project Title:Outstanding Researcher Award 2006-2007
Investigator(s):Leung SY
Department:Pathology
Source(s) of Funding:Outstanding Researcher Award
Start Date:11/2007


Project Title:Molecular and functional characterisation of novel tumour suppressor genes aberrantly down-regulated in colorectal cancer
Investigator(s):Leung SY, Chan TL, Yuen ST
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008
Completion Date:02/2012


Project Title:Research Output Prize
Investigator(s):Leung SY, Chan TL
Department:Pathology
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:12/2009


Project Title:Genomics study for new mechanism of tumour suppressor gene silencing by transcriptional interference in colorectal cancer
Investigator(s):Leung SY, Chan TL, Lok S, Yuen ST
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Investigator(s):Leung SY
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:10/2011


List of Research Outputs

Fan B., Dachrut S., Coral H., Yuen S.T., Chu K.M., Law S.Y.K., Zhang L., Ji J., Leung S.Y. and Chen X., Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer, PLoS One. 2012, 7(4): e29824.
Leung S.Y., Gastric Cancer Genomics and Genetics, Sage-Ruijin Joint Symposium in Cancer Research entitled “Translational Medicine: Use of Biomarkers and Models of Disease” organized by Sage Bionetworks, Seattle, USA, in Shanghai, China. 2012.
Leung S.Y., Genomics Study of Gastric Cancer, The 10th International Conference of the Asian Clinical Oncology Society, Seoul, South Korea. 2012.
Leung S.Y., Genomics and Genetics of Gastrointestinal Tract Cancers, The 38th Annual Meeting of Korean Cancer Association, Seoul, South Korea. 2012.
Leung S.Y., Journal Editorial Board Membership, Journal of Clinical Pathology. 2012.
Leung S.Y., Y W Kan Professorship in Natural Sciences, The University of Hong Kong. 2012.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Li CL

List of Research Outputs

Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.
Nicholls J.M., Chan W.Y., Li C.L., Yen H., Air G., Haslam S., Dell A., Walther T.J., Chan M.C.W. and Peiris J.S.M., Correlation of influenza infection with glycan array, The Fourth ESWI Conference, Malta.. 2011.


Researcher : Liu J

List of Research Outputs

Wong M.P., Lee V., Yeung R., Tin P.C., Choy G. and Liu J., Uncommon mutation types of Epidermal Growth Factor Receptor (EGFR) and tyrosine kinase inhibitor response in non-small cell lung carcinoma., In: Maria Wong, Victor Lee, Rebecca Yeung, Vicky Tin, Gigi Choy, Emily Liu Jing, AACR Conference on Molecularly Targeted Therapies: Mechanisms of Drug Resistance. San Diego. 2012.


Researcher : Liu Y

List of Research Outputs

Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Lo CK

List of Research Outputs

Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of GenoFlow HPV test and Linear Array in an Asian Screening Population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of HPV test in evaluation of atypical squamous cells of undetermined significance from Asian screening population, Scientific seminar of Hong Kong Society for Molecular Diagnostic Sciences Limited. 香港分子生物診斷學會, 2011.


Researcher : Lo CLR

Project Title:Study of the role of Dickkopf-1 (DKK1) in liver cancer
Investigator(s):Lo CLR, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:22nd Conference of the Asian Pacific Association for the Study of the Liver(APASL) Assessment of the 7th AJCC staging system in prognostic stratification of resected hepatocellular carcinoma
Investigator(s):Lo CLR
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2012
Completion Date:02/2012


Project Title:Study of testis-specific protein Y-encoded (TSPY) in hepatocellular carcinoma
Investigator(s):Lo CLR, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Lo C.L.R., Ng I.O.L. and Poon R.T.P., Assessment of the 7th AJCC staging system in prognostic stratification of resected hepatocellular carcinoma, APASL 2012.
Lo C.L.R. and Ng I.O.L., Hepatocellular Tumors-Immunohistochemical Analyses for Classification and Prognostication, Chinese Journal of Cancer Research. 2011, 23(4): 245-253.
Lo C.L.R., Invited slide seminar , Annual Scientific meeting, HKIAP. 2011.
Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.


Researcher : Loong F

List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.
Lee E.Y.P., Anthony M., Leung A.Y.H., Loong F. and Khong P.L., Utility Of FDG PET/CT In The Assessment Of Myeloid Sarcoma, AJR, American Journal of Roentgenology. 2012.


Researcher : Lu L

Project Title:Plasma cell development and its regulation in autoimmunity
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2007


Project Title:Role of leptin in regulating B cell maturation and function
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2009


Project Title:The role of IL-17 in modulating B cell functions duringin anti-viral immunity against H5N1 influenza infection in mice
Investigator(s):Lu L, Zheng B
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2011


Project Title:Role of regulatory B cells in modulating T cell functions
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2011
Completion Date:01/2012


Project Title:15th International Congress of Mucosal Immunology Role of IL-17 in modulating B cell response during influenza infection in mice
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2011
Completion Date:07/2011


Project Title:Roles of leptin in the regulation of T cell maturation and function
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2012
Completion Date:12/2012


Project Title:Roles of B cells in autoimmunity
Investigator(s):Lu L
Department:Pathology
Source(s) of Funding:Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:01/2012


List of Research Outputs

Che L.L., Xiao D.S., Xu H.X. and Lu L., Changes of iron stores and duodenal transepithelial iron transfer during regular exercise in rats, Biol Trace Elem Res. 2011, 143(2): 1044-53.
Che N., Li X., Zhou S., Liu R., Shi D., Lu L. and Sun L., Umbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation, Cell Immunol. 2012, 274(1-2): 46-53.
Li X., Liu L., Meng D., Wang D., Zhang J., Shi D., Liu H., Xu H., Lu L. and Sun L., Enhanced Apoptosis and Senescence of Bone-Marrow-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus, Stem Cells Dev. 2012.
Lu L., Role of IL-17 in modulating B cell response during influenza infection in mice, 15th International Congress of Mucosal Immunology, Paris, France . 2011.
Lu L., Roles of B cells in autoimmunity, Institute Pasteur, Paris, France. 2011.
Ma J., Zhu C., Ma B., Tian J., Baidoo S.E., Mao C., Wu W., Chen J., Tong J., Yang M., Jiao Z., Xu H., Lu L. and Wang S., Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis, Clin Dev Immunol. 2012, 2012: 827480.
Shi Y., Sandoghchian Shotorbani S., Su Z., Liu Y., Tong J., Zheng D., Chen J., Xu Y., Jiao Z., Wang S., Lu L., Huang X. and Xu H., Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis, Clin Dev Immunol. 2011, 2012: 295081.
Shotorbani S.S., He Z., Yang H., Sun Q., Xu Y., Su Z., Xue Y., Zheng D., Zhang Y., Wang S., Shao Q., Lu L. and Xu H., Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation, Cell Immunol. 2012, 275(1-2): 61-8.
Wang S., Shi Y., Yang M., Ma J., Tian J., Chen J., Mao C., Jiao Z., Ko K.H., Baidoo S.E., Xu H., Hua Z. and Lu L., Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells, Am J Pathol. 2012, 180(3): 1059-67.
Wang X., Chan C.C., Yang M., Deng J., Poon V.K., Leung V.H., Ko K.H., Zhou J., Yuen K.Y., Zheng B.J. and Lu L., A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection, Cell Mol Immunol. 2011, 8(6): 462-8.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.
Zhu C., Ma J., Liu Y., Tong J., Tian J., Chen J., Tang X., Xu H., Lu L. and Wang S., Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease, J Clin Endocrinol Metab. 2012, 97(3): 943-50.


Researcher : Lui WC

List of Research Outputs

Lui W.C., Chan L.C. and Ng R.K., Cytokine Combinations on the Potential of ex vivo Expansion of Murine Hematopoietic Stem Cells, Days of Molecular Medicine 2011. Hong Kong.
Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Deregulation of Early Hematopoietic Genes In Mouse CD41+ Leukemia Cells Exhibiting Stem Cell Property, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.


Researcher : Ma ESK

List of Research Outputs

Ng E.K.O., Leung P.H.C., Shin V.Y., Wong L.P., Ma E.S.K., Jin H.C., Chu K.M. and Kwong A., Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients, PLoS One. 2011, 6(7): e22233.
Verhovsek M., So J.C.C., O'Shea T., Gibney G.T., Ma E.S.K., Steinberg M.H. and Chui D.H., Is HbA2 level a reliable diagnostic measurement for β-thalassemia trait in people with iron deficiency?, Am J Hematol. 2012, 87(1): 114-6.


Researcher : Ma SKY

Project Title:The study of the interplay between microRNA-130b and TP53INP1 and their role in hepatocellular carcinoma
Investigator(s):Ma SKY, Guan X, Chan KW
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2010
Completion Date:07/2011


Project Title:Transcriptome sequencing (RNA-Seq) identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal carcinoma (ESCC)
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011
Completion Date:07/2012


Project Title:Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


Project Title:Cold Spring Harbor Asia Conferences - Liver Metabolism, Diseases & Cancer Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer stem cells
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


Project Title:Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):Ma SKY, Wong AST
Department:Pathology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2012


List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Ma S.K.Y., "Re-engineering Regenerative Medicine" of Days of Molecular Medicine 2011 Abstract Award, Days of Molecular Medicine. 2011.
Ma S.K.Y., Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer stem cells, Cold Spring Harbor Asia Conferences - Liver Metabolism, Diseases and Cancer. 2012.
Ma S.K.Y., Associate Editor, MicroRNA Journal. 2012.
Ma S.K.Y., Dissecting liver cancer stem cells - CD133 and beyond, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong. 2012.
Ma S.K.Y., Editorial Board, Conference Papers in Molecular Biology. 2012.
Ma S.K.Y., Editorial Board, Liver: Disease & Transplantation. 2012.
Ma S.K.Y., Faculty Outstanding Research Output Award, The University of Hong , Faculty of Medicine, The University of Hong Kong. 2011.
Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Ma S.K.Y., Liver cancer stem cells: The CD133 story, Institute of Digestive Disease (IDD) Lab Research Meeting, The Chinese University of Hong Kong. 2011.
Ma S.K.Y., Liver cancer stem cells, Karolinska Institutet – The University of Hong Kong Regenerative Medicine Workshop. 2011.
Ma S.K.Y., Young Researcher Career Development Scheme , State Key Laboratory for Liver Research, The University of Hong Kong. 2011.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.
Tong M., Ma S.K.Y. and Guan X., Biology of hepatic cancer stem cells, Journal of Gastroenterology and Hepatology. 2011, 26: 1229-37.


Researcher : Mak CM

List of Research Outputs

Lee H.H.C., Lai C.K., Yau K.C., Siu T.S., Mak C.M., Yuen Y.P., Chan K.Y., Tam S., Lam C.W. and Chan A.Y., Non-invasive urinary screening for aromatic L-amino acid decarboxylase deficiency in high-prevalence areas: a pilot study, In: Lee HC, Lai CK, Yau KC, Siu TS, Mak CM, Yuen YP, Chan KY, Tam S, Lam CW, Chan AY, Clin Chim Acta. 2012, 413:126-30.
Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.
Mak C.M., Lee C.Y., Lam C.W., Siu C.W.K., Hung V.C.N. and Chan A.Y.W., Personalized Medicine Switching from Insulin to Sulfonylurea in Permanent Neonatal Diabetes Mellitus Dictated by a Novel Activating ABCC8 Mutation, In: Chloe Miu Mak, Ching-yin Lee, Ching-wan LAM, Wai-Kwan Siu, Vanessa Ching-ngar Hung, Albert Yan-wo Chan, Diagnostic Molecular Pathology. 2012.
Mak C.M., Ko C.H., Lam C.W., Lau W.L., Siu C.W.K., Chen S.P.L., Law C.Y., Lai C.K., Yu C.M. and Chan A.Y., Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China, In: Mak CM, Ko CH, Lam CW, Lau WL, Siu WK, Chen SP, Law CY, Lai CK, Yu CM, Chan AY, Chin Med J (Engl). 2011, 124:2556-8.
Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.


Researcher : Mak KM

List of Research Outputs

Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.


Researcher : Mak TW

List of Research Outputs

Cairns R.A., Iqbal J., Lemonnier F., Kucuk C., de Leval L., Jais J.P., Parrens M., Martin A., Xerri L., Brousset P., Chan L.C., Chan W.C., Gaulard P. and Mak T.W., IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma, Blood. 2012, 119(8): 1901-1903.


Researcher : Nanji AA

Project Title:10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):Nanji AA
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2000




Researcher : Ng IOL

Project Title:Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):Ng IOL, Chan DW
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:09/2006


Project Title:Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):Ng IOL
Department:Pathology
Source(s) of Funding:Outstanding Research Student Supervisor Award
Start Date:10/2008


Project Title:Role of mitotic checkpoint gene MAD1 (mitotic arrest deficient 1) in liver cancer
Investigator(s):Ng IOL, Yam JWP
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Molecular Pathology of Liver Cancer - a Multidisciplinary Study
Investigator(s):Ng IOL, Cheung ST, Ching YP, Guan X, Jin D, Lee KW, Poon RTP, Wong CM
Department:Pathology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:05/2010


Project Title:Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):Ng IOL, Yam JWP
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010
Completion Date:05/2012


Project Title:Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):Ng IOL, Yam JWP
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:RhoE dysregulation in liver cancer and metastasis
Investigator(s):Ng IOL, Wong CM, Chan LK
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011
Completion Date:11/2012


Project Title:The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):Ng IOL, Tung KK
Department:Pathology
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:09/2011


Project Title:The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):Ng IOL
Department:Pathology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:10/2011


Project Title:The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):Ng IOL
Department:Pathology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2011


Project Title:Significance of RhoE dysregulation in liver cancer and metastasis
Investigator(s):Ng IOL, Chan LK, Wong CM
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2011


Project Title:Annual Meeting of Laennec Society Do primary HCCs already harbor specific genetic alterations that confer a metastatic capacity to the tumors?
Investigator(s):Ng IOL
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012


Project Title:Dissection of DLC1/Rho/ROCK2 signaling pathway in liver cancer
Investigator(s):Ng IOL, Chan LK
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Arzumanyan A., Friedman T., Kotei E., Ng I.O.L., Lian Z. and Feitelson M.A., Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer, Oncogene. 2012, 31(5): 563-72.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Chan K.C., Chung S.S., Ng I.O.L. and Chung S.K., The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli, Neurosignals. 2011, 20(2): 112-26.
Chan L.K., Ko F.C.F., Sze M.F., Ng I.O.L. and Yam J.W.P., Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo, PLoS ONE. 2011, 6(9): e25547.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Chen L., Liu C., Ko F.C.F., Xu N., Ng I.O.L., Yam J.W.P. and Zhu G., Solution structure of the PTB domain of human Tensin2 in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode, Journal of Biological Chemistry. 2012, 287(31): 26104-26114.
Chew V., Chen J., Lee D., Loh E., Lee J., Lim K.H., Weber A., Slankamenac K., Poon R.T.P., Yang H., Ooi L.L., Toh H.C., Heikenwalder M., Ng I.O.L., Nardin A. and Abastado J.P., Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma, Gut. 2011, 61(3): 427-438.
Chung H.Y., Chan K.L., Chan I.H.Y., Ng I.O.L., Chan G.C.F., Chan S.C. and Tam P.K.H., Clinical experience in managing post transplant lymphoproliferative disease (PTLD) in paediatric patients after liver transplant, The 45th Annual Meeting of Pacific Association of Pediatric Surgeons, Shanghai, China, 3-7 June 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Fatima S., Lee N.P.Y., Tsang F.H., Kolligs F.T., Ng I.O.L., Poon R.T.P., Fan S.T. and Luk J.M.C., Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma, Oncogene. 2012, Epub on 2012-01-16.
Hao K., Lamb J., Zhang C., Xie T., Wang K., Zhang B., Chudin E., Lee N.P.Y., Mao M., Zhong H., Greenawalt D., Ferguson M.D., Ng I.O.L., Sham P.C., Poon R.T.P., Molony C., Schadt E.E., Dai H. and Luk J.M.C., Clinicopathologic and gene expression parameters predict liver cancer prognosis, BMC Cancer. 2011, 11(1): 481.
Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781.
Lam C.Y., Yip C.W., Poon T.C.W., Cheng C.K.C., Ng E.W.Y., Wong C.L., Cheung P.F.Y., Lai P.B.S., Ng I.O.L., Fan S.T. and Cheung S.T., Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma, PLoS One. 2012, 7(7): e40324.
Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012.
Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Lee K.W., Cheung C.H. and Ng I.O.L., Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma. , Cancer letters. 2012.
Li R., Yang W., Zhang J., Hirankarn N., Pan H.F., Mok C.C., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Lee T.L., Ho M.H.K., Lee P.P.W., Chan T.M., Wong W.H.S., Wong C.M., Ng I.O.L., Yang J., Li P.H., Zhang Y., Zhang L., Li W., Baum L., Kwan P., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S., Shen N., Lau Y.L. and Ye D.Q., Association of CD247 with systemic lupus erythematosus in Asian populations, Lupus. 2012, 21(1): 75-83.
Lo C.L.R., Ng I.O.L. and Poon R.T.P., Assessment of the 7th AJCC staging system in prognostic stratification of resected hepatocellular carcinoma, APASL 2012.
Lo C.L.R. and Ng I.O.L., Hepatocellular Tumors-Immunohistochemical Analyses for Classification and Prognostication, Chinese Journal of Cancer Research. 2011, 23(4): 245-253.
Ng I.O.L., Academic Editor, PLoS ONE, 2011.
Ng I.O.L., Associate Editor, Liver International (Official journal of International Association for the Study of the Liver) . 2011.
Ng I.O.L., Do primary HCCs already harbor specific genetic alterations that confer a metastatic capacity to the tumors?, Laennec Liver Pathology Society Meeting, Heidelberg, Germany. 2012.
Ng I.O.L., Genes and Cancer, 2012.
Ng I.O.L., HCC: Biomarkers & Stratification, Fifth Annual Conference, International Liver Cancer Association, Hong Kong. 2011.
Ng I.O.L., Hepatology. 2011.
Ng I.O.L., Liver cancer stem cells in hepatocellular carcinoma, 2012 Cold Spring Harbor Asia Conference on Liver Metabolism, Disorders and Cancer, Suzhou, China. 2012.
Ng I.O.L., MicroRNA deregulation in multistep hepatocarcinogenesis, Symposium on Translational Medicine for Cancer of Digestive Systems, 2012 Forum of Sino-American Translational Medicine, Shanghai. 2012.
Ng I.O.L., Molecular & genetic advances in hepatocellular carcinoma - Molecular and genetic diagnostic and prognostic markers in HCC, International Liver Symposium 2011, Gurgaon, India. 2011.
Ng I.O.L., Molecular genetic study in HCC: MicroRNA deregulation in multistep hepatocarcinogenesis, Eastern Hepatobiliary Surgery Hospital, Shanghai. 2012.
Sze M.F., Chu K.Y. and Ng I.O.L., C-terminus-truncated hepatitis B virus X protein enhances cell invasiveness in hepatocellular carcinoma, 103rd Annual Meeting of the American Association for Cancer Research, Chicago, USA, March 31-April 04. 2012. . 2012.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.
Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.
Tung K.K., Wong Y.C., Yau T.O. and Ng I.O.L., Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion, PLoS One. 2012, 7(5): e36565.
Wong C.C.L., Gilkes D.M., Zhang H., Chen J., Wei H., Chaturvedi P., Fraley S.I., Wong C.M., Khoo U.S., Ng I.O.L., Wirtz D. and Semenza G.L., Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation, Proc Natl Acad Sci U S A. 2011, 108(39): 16369-74.
Wong C.C.L. and Ng I.O.L., Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma., Cold Spring Harbor Asia Conference. 2012.
Wong C.C.L. and Ng I.O.L., Roles and regulations of Rho-kinases in Hepatocellular Carcinoma Metastasis, Mini symposium on Cancer Cells and Stem Cells/ Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences. 2011.
Wong C.C.L. and Ng I.O.L., Roles and regulations of rho-kinases in hepatocellular carcinoma metastasis, 兩地三方會議/ The University of Hong Kong, Eastern Hepatobiliary Hospital, Shanghai Cancer Institute. 2011.
Wong C.M. and Ng I.O.L., Genomics of Hepatocellualr Carcinoma, In: Gu Jianren, Primary Liver Cancer-Challenges and Perspectives. Springer, 2012, 45-63.
Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.
Yuan K., Lian Z., Sun B., Clayton M.M., Ng I.O.L. and Feitelson M.A., Role of miR-148a in hepatitis B associated hepatocellular carcinoma, PLoS One. 2012, 7(4): e35331.


Researcher : Ng RK

Project Title:Genome-wide analysis of DNA methylation patterns in MLL-rearranged leukaemia stem cells
Investigator(s):Ng RK, Chan LC
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2009
Completion Date:03/2012


Project Title:The functional role of Bmi-1 in self-renewal of haematopoietic stem cell
Investigator(s):Ng RK
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010
Completion Date:06/2012


Project Title:The functional roles of histone H3K9 demethylase Jmjd2 family in determination of trophoblast lineages
Investigator(s):Ng RK, Lee CYL
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Role of RUNX1 in the establishment of leukemic stem cells in MLL-rearranged leukemia
Investigator(s):Ng RK
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Lam Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in Normal Hematopoietic Cells and Leukemic cells, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.
Lui W.C., Chan L.C. and Ng R.K., Cytokine Combinations on the Potential of ex vivo Expansion of Murine Hematopoietic Stem Cells, Days of Molecular Medicine 2011. Hong Kong.
Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Deregulation of Early Hematopoietic Genes In Mouse CD41+ Leukemia Cells Exhibiting Stem Cell Property, Annual meeting of International Society for Stem Cell Research 2012. Yokohama, Japan.
Ng R.K., Epigenetic dysregulation in leukemia, Karolinska Institutet - Hong Kong Regenerative Medicine Workshop. 2011.
Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.
Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011.
Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011.


Researcher : Ng TT

List of Research Outputs

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.


Researcher : Nicholls JM

Project Title:Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):Nicholls JM, Chan MCW, Kwong DLW
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2009


Project Title:Investigations into influenza receptor binding and novel therapies in an ex-vivo setting
Investigator(s):Nicholls JM
Department:Pathology
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:10/2009


Project Title:Influenza and sialic acid linked glycan interactions using virus like pseudoparticles (VLP) and STD-NMR
Investigator(s):Nicholls JM, Poon LLM
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2009


Project Title:Prevention and treatment of swine origin influenza virus (S-OIV) though the use of interferon - an in vivo and ex vivo study
Investigator(s):Nicholls JM
Department:Pathology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Sialoglyco2010 An update of inhibition of influenza infection by sialidase treatment
Investigator(s):Nicholls JM
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2010


List of Research Outputs

Chan M.C.W., Chan W.Y., Mak J.C.W., Peiris J.S.M. and Nicholls J.M., The influence of smoking on pulmonary influenza infection an ex vivo study, XIV International Symposium on Respiratory Viral Infections.. 2012.
Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.
Lai J.C.C., Garcia J.C., Dyason J.C., Böhm R., Madge P.D., Rose F.J., Nicholls J.M., Peiris J.S.M., Haselhorst T. and von Itzstein M., A secondary sialic acid binding site on influenza virus neuraminidase. Fact or fiction?, Angew Chem Int Ed Engl. . 2012, 51: 2221-4.
Nicholls J.M., Chan W.Y., Li C.L., Yen H., Air G., Haslam S., Dell A., Walther T.J., Chan M.C.W. and Peiris J.S.M., Correlation of influenza infection with glycan array, The Fourth ESWI Conference, Malta.. 2011.
Nicholls J.M., Wong L.P., Chan W.Y., Poon L.L.M., So L.K.Y., Yen H., Fung K.H.Y., van Poucke S. and Peiris J.S.M., Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods., J Virol Methods.. 2012, 179(2): 409-13.
Nicholls J.M., Lai J.C.C. and Garcia J.C., Investigating the interaction between influenza and sialic acid – making and breaking the link., In: M. von Itzstein , Milestones in Drug Therapy. Influenza Virus Sialidase - A Drug Discovery Target.. Basel, Springer Basel AG, 2011, 31-45.
Smith C., Tsang J.W.H., Beagley L., Chua D.T.T., Lee V.H.F., Li V.W.K., Moss D.J., Coman W., Chan K.H., Nicholls J.M., Kwong D.L.W. and Khanna R., Effective Treatment of Metastatic Forms of Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy , Cancer Research. 2012, 72(5): 1116-1125.
Van Poucke S., Uhlendorff J., Wang Z., Billiau V., Nicholls J.M., Matrosovich M. and Van Reeth K., Effect of receptor specificity of A/Hong Kong/1/68 (H3N2) influenza virus variants on replication and transmission in pigs, In: Van Poucke S, Uhlendorff J, Wang Z, Billiau V, Nicholls J, Matrosovich M, Van Reeth K, Influenza Other Respi Viruses. 2012.
Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.
Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses. , Journal of Virology. 2011, 85 (14): 6844-6855.
Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses., J Virol. 2011, 85(14): 6844-55.


Researcher : Poon DWT

List of Research Outputs

Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.


Researcher : Shen L

List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.


Researcher : Siu CWK

List of Research Outputs

Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.
Mak C.M., Lee C.Y., Lam C.W., Siu C.W.K., Hung V.C.N. and Chan A.Y.W., Personalized Medicine Switching from Insulin to Sulfonylurea in Permanent Neonatal Diabetes Mellitus Dictated by a Novel Activating ABCC8 Mutation, In: Chloe Miu Mak, Ching-yin Lee, Ching-wan LAM, Wai-Kwan Siu, Vanessa Ching-ngar Hung, Albert Yan-wo Chan, Diagnostic Molecular Pathology. 2012.
Mak C.M., Ko C.H., Lam C.W., Lau W.L., Siu C.W.K., Chen S.P.L., Law C.Y., Lai C.K., Yu C.M. and Chan A.Y., Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China, In: Mak CM, Ko CH, Lam CW, Lau WL, Siu WK, Chen SP, Law CY, Lai CK, Yu CM, Chan AY, Chin Med J (Engl). 2011, 124:2556-8.
Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.


Researcher : Siu KY

Project Title:Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):Siu KY, Cheung ANY
Department:Pathology
Source(s) of Funding:American Institute for Cancer Research (AICR) - General Award
Start Date:07/2006


Project Title:p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):Siu KY, Cheung ANY, Ngan HYS
Department:Pathology
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:10/2007


Project Title:Differential impact of reduced folate carrier and folate receptor alpha in ovarian cancer
Investigator(s):Siu KY, Cheung ANY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2010
Completion Date:08/2011


Project Title:Unraveling the role of Pak4 in ovarian cancer chemoresistance
Investigator(s):Siu KY, Cheung ANY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011
Completion Date:08/2011




Researcher : So JCC

Project Title:Role of chromosomal 6q23 region in the modulation of HbF production
Investigator(s):So JCC, Ma ESK, Song Y
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2007
Completion Date:09/2011


Project Title:Genetic diagnosis of hereditary spherocytosis in Chinese - a prototype for studying hereditary haemolytic anaemias
Investigator(s):So JCC
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Establishment of a Molecular Strategy for Direct Genotypic Characterisation of Moderate and Severe Haemophilia A in Hong Kong
Investigator(s):So JCC
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.
Liu A.P.Y., So J.C.C., Lam C.C.K., Ha S.Y., Chan G.C.F. and Chung B.H.Y., Clinical Quiz: What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). 2011, 16: 292.
Singh G.H., Ip A.H., So J.C.C., Cheng V.C.C., Wong C.S., Yuen K.Y. and Kwong Y.L., Disseminated cryptococcosis mimicking a lymphoma, Eur J Haematol. 2012, 88(3): 275-6.
So J.C.C., Wan T.S.K., Chow J.L., Hui K.C., Choi W.L., Lam C.C.K. and Chan L.C., A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia--evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients, Cancer Genet. 2011, 204: 430-8.
So J.C.C., Tang M.H.Y., Li C.H., Ha S.Y., Pissard S. and Chan L.C., The First Reported Case of Prenatal Diagnosis for Pyruvate Kinase Deficiency in a Chinese Family , Hematology. 2011, 16(6): 377-379.
Surapolchai P., Ha S.Y., Chiang A.K.S., Cheuk K.L.D., Li C.H., So J.C.C., Wan T.S.K. and Chan G.C.F., Challenges in the Management of Juvenile Myelomonocytic Leukaemia in Hong Kong over the Past Two Decades, HK J Paediatr . 2012, 2012;17:148-155.
Verhovsek M., So J.C.C., O'Shea T., Gibney G.T., Ma E.S.K., Steinberg M.H. and Chui D.H., Is HbA2 level a reliable diagnostic measurement for β-thalassemia trait in people with iron deficiency?, Am J Hematol. 2012, 87(1): 114-6.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.


Researcher : So LKY

List of Research Outputs

Nicholls J.M., Wong L.P., Chan W.Y., Poon L.L.M., So L.K.Y., Yen H., Fung K.H.Y., van Poucke S. and Peiris J.S.M., Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods., J Virol Methods.. 2012, 179(2): 409-13.


Researcher : Srivastava G

Project Title:Identification of direct and indirect targets of the del 6q putative tumor suppressor PRDM1 gene in NK cells, and the role of the aberrant expression of these PRDM1 downstream target genes in the pathogenesis of NK-cell malignancies
Investigator(s):Srivastava G, Liang RHS
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2009


Project Title:Inactivation of the transcriptional repressor PRDM1 and imbalance in the expression of PRDM1 ?and ?isoforms in NK-cell malignancies, and their roles in the pathogenesis
Investigator(s):Srivastava G, Liang RHS
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2009


Project Title:Tumor suppressor role of PRKCBP1, a novel translocation partner of IGH gene, in the pathogenesis of gastric and other B-cell non-Hodgkin’s lymphomas
Investigator(s):Srivastava G
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Molecular features and functional consequences of a novel recurrent t(14;20)(q32;q13.12)/IGHS?PRKCBP1 translocation in gastric and other B-cell non-Hodgkins lymphomas
Investigator(s):Srivastava G
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):Srivastava G
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Hui K.C., Lai K.Y., Chan K.W., Luk J.M., Lee N.P.Y., Chung Y., Cheung L.C., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Med Oncol.. 2012, [Epub ahead of print].
Hui K.C., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Cytoplasmic Forkhead Box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage, World Journal of Surgery. 2012, 36(1): 90-97.
Küçük C., Iqbal J., Hu X., Gaulard P., De Leval L., Srivastava G., Au W.Y., McKeithan T.W. and Chan W.C., PRDM1 is a tumor suppressor gene in natural killer cell malignancies, Proc Natl Acad Sci U S A . 2011, 108(50): 20119-24.
Li L., Ying J., Li H., Zhang Y., Shu X., Fan Y., Tan J., Cao Y., Tsao G.S.W., Srivastava G., Chan A.T. and Tao Q., The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas, Oncogene. 2011, [Epub ahead of print].
Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45.
Love C.L., Jima D., Zhang J., Grubor V., Miles R.R., Dunphy C.H., Richards K.L., Choi W.L., Au W.Y., Srivastava G., Chadburn A., Gordon L.I., Evens A.M., Hsi E.D., Czader M., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Sunay S., Flowers C.R., Naresh K., Thompson M.A., Gill J. and Dave S.S., Whole genome and exome sequencing reveals the genetic landscape of Burkitt lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Shu X.S., Geng H., Li L., Ying J., Ma C., Wang Y., Poon F.F., Wang X., Ying Y., Yeo W., Srivastava G., Tsao G.S.W., Yu J., Sung J.J., Huang S., Chan A.T. and Tao Q., The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors, PLoS One. 2011, 6(11): e27346.
Srivastava G., Editor & Editorial Board Member of International Journal of Medical Sciences. Ivyspring International Publisher, 2012.
Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.
Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Miezcowski P., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D.D., Luftig M., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B. and Dave S.S., The genetic landscape of immune-competent and HIV lymphoma, 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). 2012.


Researcher : Surapolchai P

List of Research Outputs

Surapolchai P., Ha S.Y., Chiang A.K.S., Cheuk K.L.D., Li C.H., So J.C.C., Wan T.S.K. and Chan G.C.F., Challenges in the Management of Juvenile Myelomonocytic Leukaemia in Hong Kong over the Past Two Decades, HK J Paediatr . 2012, 2012;17:148-155.


Researcher : Sze MF

Project Title:The functional characterizations of Proline Rich acidic protein 1 (PRAP1) in chromosomal segregation machinery via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):Sze MF, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2012


Project Title:AACR 103rd Annual Meeting 2012 C-terminus-truncated hepatitis B virus X protein enhances cell invasiveness in hepatocellular carcinoma
Investigator(s):Sze MF
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2012
Completion Date:04/2012


List of Research Outputs

Chan L.K., Ko F.C.F., Sze M.F., Ng I.O.L. and Yam J.W.P., Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo, PLoS ONE. 2011, 6(9): e25547.
Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Sze M.F., Chu K.Y. and Ng I.O.L., C-terminus-truncated hepatitis B virus X protein enhances cell invasiveness in hepatocellular carcinoma, 103rd Annual Meeting of the American Association for Cancer Research, Chicago, USA, March 31-April 04. 2012. . 2012.


Researcher : Szeto E

List of Research Outputs

Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of GenoFlow HPV test and Linear Array in an Asian Screening Population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.


Researcher : Szeto EF

List of Research Outputs

Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of HPV test in evaluation of atypical squamous cells of undetermined significance from Asian screening population, Scientific seminar of Hong Kong Society for Molecular Diagnostic Sciences Limited. 香港分子生物診斷學會, 2011.


Researcher : Tam HKA

List of Research Outputs

Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.


Researcher : Tam S

List of Research Outputs

Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Lee H.H.C., Lai C.K., Yau K.C., Siu T.S., Mak C.M., Yuen Y.P., Chan K.Y., Tam S., Lam C.W. and Chan A.Y., Non-invasive urinary screening for aromatic L-amino acid decarboxylase deficiency in high-prevalence areas: a pilot study, In: Lee HC, Lai CK, Yau KC, Siu TS, Mak CM, Yuen YP, Chan KY, Tam S, Lam CW, Chan AY, Clin Chim Acta. 2012, 413:126-30.
Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.


Researcher : Tang JCO

List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Hui K.C., Lai K.Y., Chan K.W., Luk J.M., Lee N.P.Y., Chung Y., Cheung L.C., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Med Oncol.. 2012, [Epub ahead of print].
Hui K.C., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Cytoplasmic Forkhead Box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage, World Journal of Surgery. 2012, 36(1): 90-97.
Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95.


Researcher : Tang KH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.


Researcher : Tang KH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation, Cell Stem Cell. 2011, 9: 50-63.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote angiogenesis and tumor growth through neurotensin-induced interleukin-8 signaling activation, Days of Molecular Medicine 2011 - "Re-engineering Regenerative Medicine". 2011.
Tang K.H., Ma S.K.Y., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through neurotensin-induced interleukin-8 signaling activation , International Liver Cancer Association - Annual Meeting 2011.


Researcher : Tin PC

List of Research Outputs

Wong M.P., Lee V., Yeung R., Tin P.C., Choy G. and Liu J., Uncommon mutation types of Epidermal Growth Factor Receptor (EGFR) and tyrosine kinase inhibitor response in non-small cell lung carcinoma., In: Maria Wong, Victor Lee, Rebecca Yeung, Vicky Tin, Gigi Choy, Emily Liu Jing, AACR Conference on Molecularly Targeted Therapies: Mechanisms of Drug Resistance. San Diego. 2012.


Researcher : Tong M

List of Research Outputs

Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tong M., Ma S.K.Y. and Guan X., Biology of hepatic cancer stem cells, Journal of Gastroenterology and Hepatology. 2011, 26: 1229-37.


Researcher : Tong M

List of Research Outputs

Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686.
Tang K.H., Ma S.K.Y., Lee K.W., Chan Y.P., Kwan P.S., Tong M., Ng I.O.L., Man K., To K.F., Lai P.B., Lo C.M., Guan X. and Chan K.W., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatology. 2011, 55(3): 807-820.
Tong M., Ma S.K.Y. and Guan X., Biology of hepatic cancer stem cells, Journal of Gastroenterology and Hepatology. 2011, 26: 1229-37.


Researcher : Tong SF

List of Research Outputs

Mak C.M., Lam C.W., Fong N.C., Siu C.W.K., Lee H.H.C., Siu T.S., Lai C.K., Law C.Y., Tong S.F., Poon D.W.T., Lam D.S., Ng H.L., Yuen Y.P., Tam S., Que T.L., Kwong N.S. and Chan A.Y., Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants, In: Mak CM, Lam CW, Fong NC, Siu WK, Lee HC, Siu TS, Lai CK, Law CY, Tong SF, Poon WT, Lam DS, Ng HL, Yuen YP, Tam S, Que TL, Kwong NS, Chan AY, J Hum Genet. 2011, 56:617-21.
Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.
Wu J., Leung K.F., Tong S.F. and Lam C.W., Organochlorine isotopic pattern‐enhanced detection and quantification of triclosan and its metabolites in human serum by ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight/mass spectrometry, In: Jian‐lin Wu, Ka‐Fai Leung, Sui‐Fan Tong, Ching‐Wan Lam, Rapid Communications in Mass Spectrometry. 2012.
Zha Y., Chen X.M., Lam C.W., Lee S.C., Tong S.F. and Gao Z.Q., Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients, In: Zha Y, Chen XM, Lam CW, Lee SC, Tong SF, Gao ZQ, Laryngoscope. 2011, 121:1760-4.


Researcher : Tsang FH

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.


Researcher : Tse EYT

List of Research Outputs

Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.


Researcher : Tsui WY

List of Research Outputs

Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Tsun OKL

List of Research Outputs

Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of GenoFlow HPV test and Linear Array in an Asian Screening Population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.


Researcher : Tung KK

Project Title:Characterization of Prickle2 in liver cancer
Investigator(s):Tung KK, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:12/2010
Completion Date:05/2012


List of Research Outputs

Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.
Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.
Tung K.K., Wong Y.C., Yau T.O. and Ng I.O.L., Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion, PLoS One. 2012, 7(5): e36565.


Researcher : Walther TJ

List of Research Outputs

Nicholls J.M., Chan W.Y., Li C.L., Yen H., Air G., Haslam S., Dell A., Walther T.J., Chan M.C.W. and Peiris J.S.M., Correlation of influenza infection with glycan array, The Fourth ESWI Conference, Malta.. 2011.


Researcher : Wan TSK

List of Research Outputs

Chim J.C.S., Wan T.S.K., Wong K.Y., Fung T.K., Drexler H.G. and Wong K.F., Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms, Journal of Translational Medicine. 2011, 197.
Meyer C., Kowarz E., Yip S.F., Wan T.S.K., Chan T.K., Dingermann T., Chan L.C. and Marschalek R., A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia, Cancer Genetics . 2011, 204: 430-438.
So J.C.C., Wan T.S.K., Chow J.L., Hui K.C., Choi W.L., Lam C.C.K. and Chan L.C., A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia--evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients, Cancer Genet. 2011, 204: 430-8.
Surapolchai P., Ha S.Y., Chiang A.K.S., Cheuk K.L.D., Li C.H., So J.C.C., Wan T.S.K. and Chan G.C.F., Challenges in the Management of Juvenile Myelomonocytic Leukaemia in Hong Kong over the Past Two Decades, HK J Paediatr . 2012, 2012;17:148-155.
Yung S.Y.J., Tse H.F., Wan T.S.K., Tam P.K.H. and Ngan E.S.W., Modelling Hirschsprung’s disease using patient-specific iPS cells, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25 - 28 March 2012.


Researcher : Wang X

List of Research Outputs

Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Wei L

List of Research Outputs

Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Wei L., Le X.C., Xia Z., Han Y. and Rong J., PHARMACOLOGICAL INDUCTION OF LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE (LTB4DH) IN HUMAN NEUTROPHILS AND ITS POTENTIAL IN THE TREATMENT OF MYOCARDIAL INJURY, the International Academy of Cardiology, 16th WORLD CONGRESS ON HEART DISEASE, Annual Scientific Sessions 2011. Vancouver, BC, Canada.


Researcher : Wong CCL

Project Title:Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):Wong CCL, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):Wong CCL
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012


List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Wong C.C.L., Gilkes D.M., Zhang H., Chen J., Wei H., Chaturvedi P., Fraley S.I., Wong C.M., Khoo U.S., Ng I.O.L., Wirtz D. and Semenza G.L., Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation, Proc Natl Acad Sci U S A. 2011, 108(39): 16369-74.
Wong C.C.L. and Ng I.O.L., Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma., Cold Spring Harbor Asia Conference. 2012.
Wong C.C.L. and Ng I.O.L., Roles and regulations of Rho-kinases in Hepatocellular Carcinoma Metastasis, Mini symposium on Cancer Cells and Stem Cells/ Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences. 2011.
Wong C.C.L. and Ng I.O.L., Roles and regulations of rho-kinases in hepatocellular carcinoma metastasis, 兩地三方會議/ The University of Hong Kong, Eastern Hepatobiliary Hospital, Shanghai Cancer Institute. 2011.
Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.


Researcher : Wong CL

Project Title:Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):Wong CCL, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):Wong CCL
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012


List of Research Outputs



Researcher : Wong CM

Project Title:Roles of histone methyltransferases SUV39H1 and SUV39H2 in liver cancer
Investigator(s):Wong CM, Ng IOL
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008
Completion Date:08/2011


Project Title:Epigenetic alteration and miRNA deregulation in liver cancer
Investigator(s):Wong CM, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010
Completion Date:05/2012


Project Title:Characterization of EZH2 mediated miRNA deregulation in liver cancer
Investigator(s):Wong CM, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2011


Project Title:Polycomb silencing and microRNA deregulation in liver cancer
Investigator(s):Wong CM
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2011


Project Title:Hypoxia and SETDB1 up-regulation in liver cancer
Investigator(s):Wong CM, Wong CCL, Ng IOL
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2012


Project Title:CSH-Asia Conference: Liver Metabolism, Diseases & Cancer Upregulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis
Investigator(s):Wong CM
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Tsang F.H., Ng I.O.L. and Wong C.M., Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis, Hepatology. 2012, 56: 622.
Au L.K.S., Wong C.C.L., Lee M.F., Fan N.Y., Ng I.O.L. and Wong C.M., Overexpression of Enhancer of Zeste homolog 2 (EZH2) promotes HCC metastasis via epigenetic silencing of multiple anti-metastatic microRNAs, 5th Annual Conference of International Liver Cancer Association. 2011.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Fan N.Y., Tsang F.H., Au L.K.S., Wei L., Tam H.K.A., Ng I.O.L. and Wong C.M., SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b, American Association for Cancer Research Annual Meeting 2012.
Fan N.Y., Tsang F.H., Au L.K.S., Tam H.K.A., Wong C.C.L., Wei L., Lee M.F., Ng I.O.L. and Wong C.M., Up-regulation of histone methyltransferase SUV39H1 promotes liver cancer growth and metastasis, Cold Spring Harbor Asia Conferences: Liver metabolism, Diseases and Cancer. 2012.
Lei Z., Li L., Li G., Leung C.W., Shi J., Wong C.M., Mak S.K., Chan S.B., Chan N., Leung C.H., Lai P.T. and Pong P.W.T., Liver Cancer Immunoassay with Magnetic Nanoparticles and MgO-Based Magnetic Tunnel Junction Sensors, 56th Annual Conference on Magnetism and Magnetic Materaisl. Scottsdale, Arizona, 2011, DV-07.
Li L., Lei Z., Mak K.Y., Leung C.W., Shi J., Wong C.M., Chan W.K., Lin K.W., Chan N.M.M., Leung C.H., Wu E.X. and Pong P.W.T., HIV Disease Detection Platform with Magnetic Nanoparticles and MgO-Based Magnetic Tunnel Junction Sensors, International Symposium on Integrated Functionalities. Hong Kong, 2012, P810.
Li L., Lei Z., Mak K.Y., Leung C.W., Shi J., Wong C.M., Chan W.K., Lin K.W., Chan N., Leung C.H., Wu E.X. and Pong P.W.T., HIV Disease Immunoassay with Magnetic Nanoparticles and MgO-Based Magnetic Tunnel Junction Sensors, IEEE International Magnetics Conference 2012. Vancouver, Canada, FF-09.
Li L., Mak K.Y., Shi J., Leung C.H., Wong C.M., Leung C.W., Mak S.K., Chan N.M.M., Chan S.B. and Pong P.W.T., In vitro Cytotoxicity Study of Magnetic Iron Oxide Nanoparticles on Normal Human Cells (RPE) and Cancer Cells (HeLa), 6th International Conference on Surfaces, Coatings and Nano-Structured Materials. Krakow, Poland, 2011, NANO-100.
Li R., Yang W., Zhang J., Hirankarn N., Pan H.F., Mok C.C., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Lee T.L., Ho M.H.K., Lee P.P.W., Chan T.M., Wong W.H.S., Wong C.M., Ng I.O.L., Yang J., Li P.H., Zhang Y., Zhang L., Li W., Baum L., Kwan P., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S., Shen N., Lau Y.L. and Ye D.Q., Association of CD247 with systemic lupus erythematosus in Asian populations, Lupus. 2012, 21(1): 75-83.
Mak K.Y., Li L., Wong C.M., Leung C.W., Chan S.B., Shi J., Koon H.K., Mak S.K., Chan M.M. and Pong P.W.T., Biocompatibility of PDMS Microgrooves and Nanoporous Anodized Aluminum Membrane to Bel-7402 Cells and Their Effects on Cell Adhesion, Cell Spreading and Cell Motility, 6th International Conference on Surfaces, Coatings and Nano-Structured Materials. Krakow, Poland, 2011, NANO-101.
Wong C.C.L., Gilkes D.M., Zhang H., Chen J., Wei H., Chaturvedi P., Fraley S.I., Wong C.M., Khoo U.S., Ng I.O.L., Wirtz D. and Semenza G.L., Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation, Proc Natl Acad Sci U S A. 2011, 108(39): 16369-74.
Wong C.M., Aberrant polycomb silencing and microRNA deregulation in hepatocellular carcinoma,, Shanghai Cancer Institute, Shanghai, China. 2011.
Wong C.M., Editoral Board Member, ISRN Genetics. 2012.
Wong C.M. and Ng I.O.L., Genomics of Hepatocellualr Carcinoma, In: Gu Jianren, Primary Liver Cancer-Challenges and Perspectives. Springer, 2012, 45-63.
Wong C.M., MicroRNA deregulation and HCC metastasis, State Key Laboratory for Liver Research (SKLLR) Symposium 2011. 2011.
Wong C.M., Wong C.C.L., Lee M.F., Fan N.Y., Au L.K. and Ng I.O.L., Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis, Hepatology. 2012, 55 (5): 1453-1461.
Wong C.M., The implications of microRNA deregulation in liver cancer metastasis , National Taiwan University and University of Southern California joint symposium on “Frontiers in Liver Disease Research: New Molecular Targets for Liver Fibrosis, Hepatitis, and Liver Cancer”. 2011.


Researcher : Wong ESY

List of Research Outputs

Zhao F., Siu M.K., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Histopathology, In: Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Chan HY, Cheung AN, Histopathology. 2011.


Researcher : Wong GW

Project Title:Adipokines contributing to endometrial carcinogenesis
Investigator(s):Wong GW, Cheung ANY
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


List of Research Outputs

Siu C.W.K., Law C.Y., Lam C.W., Mak C.M., Wong G.W., Ho A.Y., Ho K.Y., Loo K.T., Chiu S.C., Chow L.T., Tong S.F. and Chan A.Y., Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors, In: Siu WK, Law CY, Lam CW, Mak CM, Wong GW, Ho AY, Ho KY, Loo KT, Chiu SC, Chow LT, Tong SF, Chan AY, Fam Cancer. 2011, 10:695-9.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of GenoFlow HPV test and Linear Array in an Asian Screening Population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Chow N.K., Tsun O.K.L., Szeto E., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population., J Clin Microbiol.. 2012, 50(5): 1691-7.
Wong G.W., Lo C.K., Chow J.N., Tsun O.K.L., Szeto E., Liu S.S., Ngan H.Y.S. and Cheung A.N.Y., Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population, In: Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, Ngan HY, Cheung AN, J Clin Microbiol. 2012.
Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of HPV test in evaluation of atypical squamous cells of undetermined significance from Asian screening population, Scientific seminar of Hong Kong Society for Molecular Diagnostic Sciences Limited. 香港分子生物診斷學會, 2011.
Wong G.W., Jiang L. and Cheung A.N.Y., iASPP and Chemoresistance in Ovarian Cancers–Paclitaxel-Mediated Mitotic Catastrophe and Apoptosis, Croucher Advanced Study Institute 2012 Tumour Microenvironment - New Concepts and Molecular Mechanisms. 2012.
Zhao F., Siu M.K., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Histopathology, In: Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Chan HY, Cheung AN, Histopathology. 2011.
Zhou C., Wong G.W., Masters J. and Williamson M., Effect of cancer-associated mutations in the PlexinB1 gene, Molecular Cancer. 2012, 11.


Researcher : Wong KY

List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.


Researcher : Wong M.P.

Project Title:Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):Wong MP, Chua DTT
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2005


Project Title:Generation of a versatile and inducible EGFRL858R mouse lung cancer model and its application for studying gene collaboration in lung carcinogenesis
Investigator(s):Wong MP, Leung LH, Cai K
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:09/2011


Project Title:p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):Wong MP, Cai K
Department:Pathology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2011


Project Title:p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):Wong MP, Leung LH
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):Wong MP, Sham MH, Wang JJ
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Genetic causes of tyrosine kinase inhibitor resistance in advanced lung cancer patients
Investigator(s):Wong MP, Lee VHF
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:Moleculary targeted therapies: Mechanisms of Resistance Uncommon mutation types of Epidermal Growth Factor Receptor (EGFR) and tyrosine kinase inhibitor response in non-small cell lung carcinoma
Investigator(s):Wong MP
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


List of Research Outputs



Researcher : Wong MLY

List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S.Y.K., Srivastava G., Lappin T.R., Chan K.W. and EI-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, American Journal of Pathology. 2011, 179(2): 992-1003.


Researcher : Wong MP

Project Title:Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):Wong MP, Chua DTT
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:11/2005


Project Title:Generation of a versatile and inducible EGFRL858R mouse lung cancer model and its application for studying gene collaboration in lung carcinogenesis
Investigator(s):Wong MP, Leung LH, Cai K
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:09/2011


Project Title:p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):Wong MP, Cai K
Department:Pathology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2011


Project Title:p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):Wong MP, Leung LH
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):Wong MP, Sham MH, Wang JJ
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Genetic causes of tyrosine kinase inhibitor resistance in advanced lung cancer patients
Investigator(s):Wong MP, Lee VHF
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:Moleculary targeted therapies: Mechanisms of Resistance Uncommon mutation types of Epidermal Growth Factor Receptor (EGFR) and tyrosine kinase inhibitor response in non-small cell lung carcinoma
Investigator(s):Wong MP
Department:Pathology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


List of Research Outputs

Lam C.L.D., Girard L., Beer D.G., Gerald W.L., Kris M., Sihoe A.D.L., Cheng L.C., Wong M.P., Chung L.P., Ip M.S.M., Lam W.K., Gazdar A.F., Wistuba I.I. and Minna J.D., Expression of LATS2 and STK17B distinguishes epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 from those in 18 and 20 in lung adenocarcinomas, World Congress of Lung Cancer 2011.
Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.
Siu D.C.W., Wong M.P., Ho J.C.M., Lam C.L.D. and Tse H.F., Fatal lung toxicity related to Dronedarone use., Arch Int Med . 2012, 172 (6): 516 - 517.
Wong M.P., Lee V., Yeung R., Tin P.C., Choy G. and Liu J., Uncommon mutation types of Epidermal Growth Factor Receptor (EGFR) and tyrosine kinase inhibitor response in non-small cell lung carcinoma., In: Maria Wong, Victor Lee, Rebecca Yeung, Vicky Tin, Gigi Choy, Emily Liu Jing, AACR Conference on Molecularly Targeted Therapies: Mechanisms of Drug Resistance. San Diego. 2012.


Researcher : Wong SY

List of Research Outputs

Karadedou C.T., Gomes A.R., Chen J., Petkovic M., Ho K.K., Zwolinska A.K., Feltes A., Wong S.Y., Chan Y.K., Cheung Y.N., Tsang J.W.H., Brosens J.J., Khoo U.S. and Lam E.W., FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer, Oncogene. 2012, 31(14): 1845-58.
Yuen H.F., Zhang S.D., Wong S.Y., McCrudden C.M., Huang Y.H., Chan Y.K., El-Tanani M. and Khoo U.S., Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients", Breast Cancer Res Treat. 2012, 131(1): 351-2.


Researcher : Wong YC

List of Research Outputs

Tung K.K., Wong Y.C., Yau T.O. and Ng I.O.L., Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion, PLoS One. 2012, 7(5): e36565.


Researcher : Wu J

Project Title:Total triclosan in the plasma and urine samples in Hong Kong People
Investigator(s):Wu J, Lam CW
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:10/2011


List of Research Outputs

Wu J., Leung K.F., Tong S.F. and Lam C.W., Organochlorine isotopic pattern‐enhanced detection and quantification of triclosan and its metabolites in human serum by ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight/mass spectrometry, In: Jian‐lin Wu, Ka‐Fai Leung, Sui‐Fan Tong, Ching‐Wan Lam, Rapid Communications in Mass Spectrometry. 2012.


Researcher : Yam JWP

Project Title:Outstanding Young Researcher Award 2008-2009
Investigator(s):Yam JWP
Department:Pathology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2009


Project Title:Role of caveolin-1 in liver cancer metastasis through HGF/Met signaling pathway
Investigator(s):Yam JWP, Wong AST
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010
Completion Date:05/2012


Project Title:Interplay of caveolin-1 and met receptor in liver cancer metastasis
Investigator(s):Yam JWP, Wong AST
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Impact of nuclear translocation of Met receptor in liver cancer progression
Investigator(s):Yam JWP, Wong AST
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:Functional significance of nuclear Met-driven nuclear factor kappa B pathway in liver cancer
Investigator(s):Yam JWP, Wong AST
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan L.K., Ko F.C.F., Sze M.F., Ng I.O.L. and Yam J.W.P., Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo, PLoS ONE. 2011, 6(9): e25547.
Chen L., Liu C., Ko F.C.F., Xu N., Ng I.O.L., Yam J.W.P. and Zhu G., Solution structure of the PTB domain of human Tensin2 in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode, Journal of Biological Chemistry. 2012, 287(31): 26104-26114.
Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.
Tse E.Y.T., Ko F.C.F., Tung K.K., Chan L.K., Lee K.W., Ngan E.S.W., Man K., Wong A.S.T., Ng I.O.L. and Yam J.W.P., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis, Journal of Pathology. 2011, 226(4): 645-653.
Yam J.W.P., Academic Editor, PLoS ONE, Public Libraray of Science. 2012.
Yam J.W.P., Invited Lecture, Symposium 2011, State Key Laboratory for Liver Research (SKLLR), Advances in Liver Research and Liver Diseases: Frontiers in Liver Research – From Bench to Bedside. 2011.


Researcher : Yan HHN

Project Title:Roles of paracrine Hedgehog signaling on tumorigenesis and cancer stem cells in colorectal cancer
Investigator(s):Yan HHN, Leung SY
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:01/2012




Researcher : Yang M

List of Research Outputs

Ma J., Zhu C., Ma B., Tian J., Baidoo S.E., Mao C., Wu W., Chen J., Tong J., Yang M., Jiao Z., Xu H., Lu L. and Wang S., Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis, Clin Dev Immunol. 2012, 2012: 827480.
Wang S., Shi Y., Yang M., Ma J., Tian J., Chen J., Mao C., Jiao Z., Ko K.H., Baidoo S.E., Xu H., Hua Z. and Lu L., Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells, Am J Pathol. 2012, 180(3): 1059-67.
Wang X., Chan C.C., Yang M., Deng J., Poon V.K., Leung V.H., Ko K.H., Zhou J., Yuen K.Y., Zheng B.J. and Lu L., A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection, Cell Mol Immunol. 2011, 8(6): 462-8.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Yang M

List of Research Outputs

Ma J., Zhu C., Ma B., Tian J., Baidoo S.E., Mao C., Wu W., Chen J., Tong J., Yang M., Jiao Z., Xu H., Lu L. and Wang S., Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis, Clin Dev Immunol. 2012, 2012: 827480.
Wang S., Shi Y., Yang M., Ma J., Tian J., Chen J., Mao C., Jiao Z., Ko K.H., Baidoo S.E., Xu H., Hua Z. and Lu L., Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells, Am J Pathol. 2012, 180(3): 1059-67.
Wang X., Chan C.C., Yang M., Deng J., Poon V.K., Leung V.H., Ko K.H., Zhou J., Yuen K.Y., Zheng B.J. and Lu L., A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection, Cell Mol Immunol. 2011, 8(6): 462-8.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.


Researcher : Yau TO

Project Title:The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):Yau TO, Ng IOL
Department:Pathology
Source(s) of Funding:Small Project Funding
Start Date:10/2006


List of Research Outputs

Tung K.K., Wong Y.C., Yau T.O. and Ng I.O.L., Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion, PLoS One. 2012, 7(5): e36565.


Researcher : Yeung YS

List of Research Outputs

Ko F.C.F., Chan L.K., Tse E.Y.T., Yeung Y.S., Sze M.F., Ng I.O.L. and Yam J.W.P., cAMP/PKA signaling enhances activity of Deleted in Liver Cancer 1 (DLC1) tumor suppressor in suppressing liver cancer tumorigenesis, American Association for Cancer Research 103rd Annual Meeting, Chicago IL, USA. 2012.


Researcher : Yip SF

List of Research Outputs

Meyer C., Kowarz E., Yip S.F., Wan T.S.K., Chan T.K., Dingermann T., Chan L.C. and Marschalek R., A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia, Cancer Genetics . 2011, 204: 430-438.
Tse E.W.C., Leung A.Y.H., Sim P.Y.J., Lee H.K., Liu H.S., Yip S.F. and Kwong Y.L., Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia., ANNALS OF HEMATOLOGY. 2011, 90(11): 1277-81.


Researcher : Yu CL

List of Research Outputs

Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.
Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses., J Virol. 2011, 85(14): 6844-55.


Researcher : Yuen HF

List of Research Outputs

Yuen H.F., McCrudden C.M., Grills C., Zhang S.D., Huang Y.H., Chan K.K., Chan Y.P., Wong M.L.Y., Law S.Y.K., Srivastava G., Fennell D.A., Dickson G., El-Tanani M. and Chan K.W., Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression, Cancer Sci. 2012, 103(6): 1145-54.
Yuen H.F., Zhang S.D., Wong S.Y., McCrudden C.M., Huang Y.H., Chan Y.K., El-Tanani M. and Khoo U.S., Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients", Breast Cancer Res Treat. 2012, 131(1): 351-2.


Researcher : Yuen KM

List of Research Outputs

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.


Researcher : Yuen ST

List of Research Outputs

Fan B., Dachrut S., Coral H., Yuen S.T., Chu K.M., Law S.Y.K., Zhang L., Ji J., Leung S.Y. and Chen X., Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer, PLoS One. 2012, 7(4): e29824.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, AACR Special Conference on Translation of the Cancer Genome: Scientific, Clinical, and Operational Challenges, San Francisco, CA, U.S.A. October. 2011.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer, Nature Genetics. 2011, 43(12): 1219-1223.
Wang K., Kan J., Yuen S.T., Shi S.T., Chu K.M., Law S.Y.K., Chan T.L., Kan Z., Chan A.S.Y., Tsui W.Y., Lee S.P., Ho R.S.L., Chan K.W., Cheng H.W.G., Roberts P.C., Rejto P.A., Gibson N.W., Pocalyko D.J., Mao M., Xu J. and Leung S.Y., Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012, 43(12): 1219-23.


Researcher : Zhao F

List of Research Outputs

Zhao F., Siu M.K., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Histopathology, In: Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Chan HY, Cheung AN, Histopathology. 2011.


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