DEPT OF ANATOMY
| Researcher : Chan CWY |
| Project Title: | Interferon-producing killer dendritic cells in infection |
| Investigator(s): | Chan CWY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 07/2010 |
| Completion Date: | 07/2011 |
| Project Title: | Pluripotent stem cells as source of dendritic cell-based immune therapy to induce tolerance. |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Chan C.W.Y., Dendritic cells and stem cells, Karolinska Institute, Sweden. 2011. |
| Chan C.W.Y., Immunology of Stem Cells, CAS-HKU Stem Cell Exchange. 2012. |
| Fu J.D., Rushing S.N., Lieu D.K., Chan C.W.Y., Kong M.C.W., Geng L., Wilson K.D., Chiamvimonvat N., Boheler K.R. and Wu J.C., Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes, PLoS One. 2011, 6(11): e27417. |
| Li R.A., Chan C.W.Y., Kong M.C.W., Kenneth R. Boheler K.B., Ji-Dong Fu J.D.F., Stephanie N. Rushing, S.R., Deborah K. Lie D.L., Geng L., Kitchener D. Wilson K.W., Nipavan Chiamvimonvat N.C. and Joseph C. Wu J.W., Gordon Keller G.K., Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes., PloS One. 6(11):e27417.. 2011. |
| Lui O.L.K., Bu L., Li R.A. and Chan C.W.Y., Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives. , Birth Defects Res C Embryo Today. 2012, 96. |
| Tso H.W., Yim L.Y., Lau K.L.K., Li R.A. and Chan C.W.Y., Distinct immunomodulatory effect of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells, Re-engineering Regenerative Medicine 2012. 2011. |
| Researcher : Chan KC |
| List of Research Outputs |
| Chan K.C., Chung S.S., Ng I.O.L. and Chung S.K., The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli, Neurosignals. 2011, 20(2): 112-26. |
| Researcher : Chan ML |
| List of Research Outputs |
| Chan M.L., A study of RhoV and PAK4 signaling in hepatocarcinogenesis. 2011, 103 pages. |
| Researcher : Chan PK |
| List of Research Outputs |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Researcher : Chan TF |
| List of Research Outputs |
| Chan T.F., Chiu K., Lok C.K.M., Ho W.L., So K.F. and Chang R.C.C., Morphometric analyses of retinal sections, Journal of Visualized Experiments. 2012, 60: pii 3377 doi: 10.3791/3377. |
| Chiu K., Chan T.F., Wu A.G.K., Leung I.Y.P., So K.F. and Chang R.C.C., Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?, Age. 2012, 34: 633-649. |
| Ho Y.S., Poon C.H., Chan T.F. and Chang R.C.C., From small to big molecules: How do we prevent and delay the progression of age-related neurodegeneration?, Current Pharmaceutical Design. 2012, 18: 15-26. |
| Researcher : Chan TK |
| Project Title: | Introduction of presumed consent and implementation of other measures to promote cadeveric kidney donation in Hong Kong: public attitudes and review of legal and ethical principles – implications of public health policy |
| Investigator(s): | Chan TK, Cowling BJ |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2012 |
| Researcher : Chang R.C.C. |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Investigating the efficacy of minocycline as neuroprotective agent against cytokine storm-mediated neurotoxicity |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Elucidating the pathophysiological significance of endoplasmic reticulum aggregation in neurons stressed by ?amyloid peptide and in Alzheimers disease' |
| Investigator(s): | Chang RCC, Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Elucidating pathophysiological mechanisms of synaptic and axonal degeneration in depression and Alzheimer's disease |
| Investigator(s): | Chang RCC, Ho YS, Law ACK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Completion Date: | 03/2012 |
| Project Title: | Society for Neuroscience Annual Meeting (Neuroscience 2011) Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric β-amyloid peptide-treated neurons |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2011 |
| Completion Date: | 11/2011 |
| Project Title: | Impact of tau protein on corticosterone-induced depression to synergize neurodegeneration in Alzheimer’s disease |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Investigating the efficacy of minocycline as neuroprotective agent against cytokine storm-mediated neurotoxicity |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Elucidating the pathophysiological significance of endoplasmic reticulum aggregation in neurons stressed by ?amyloid peptide and in Alzheimers disease' |
| Investigator(s): | Chang RCC, Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Elucidating pathophysiological mechanisms of synaptic and axonal degeneration in depression and Alzheimer's disease |
| Investigator(s): | Chang RCC, Ho YS, Law ACK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Completion Date: | 03/2012 |
| Project Title: | Society for Neuroscience Annual Meeting (Neuroscience 2011) Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric β-amyloid peptide-treated neurons |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2011 |
| Completion Date: | 11/2011 |
| Project Title: | Impact of tau protein on corticosterone-induced depression to synergize neurodegeneration in Alzheimer’s disease |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Chan K.H. and Chang R.C.C., Co-chairman of Organizing Committee of 7th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012. |
| Chan T.F., Chiu K., Lok C.K.M., Ho W.L., So K.F. and Chang R.C.C., Morphometric analyses of retinal sections, Journal of Visualized Experiments. 2012, 60: pii 3377 doi: 10.3791/3377. |
| Chang R.C.C., Advanced Understanding of Neurodegenerative Diseases. Croatia, InTech, 2011, 1-442. |
| Chang R.C.C., Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric beta-amyloid peptide-treated neurons., Society for Neuroscience, Washington DC, USA, 2011. 2011. |
| Chang R.C.C., Zhang Q., Hung H.L., Ho Y.S. and Wuwongse S., Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric b-amyloid peptide-treated neurons, Society for Neuroscience 2011. Program#/Poster#: 637.10. |
| Chang R.C.C., Anatomy of Dementia, Certificate Course of Dementia for Geriatrics, Academy for Geriatrics and Lundbeck Institute of Medicine Hong Kong. 2011. |
| Chang R.C.C., Co-Chairman of Organizing Committee, Alzheimer's Disease Conference 2012. 2012. |
| Chang R.C.C., Co-Chairman of Organizing Committee, The 7th International Symposium on Healthy Aging. 2012. |
| Chang R.C.C., Collapse of the endoplasmic reticulum triggers initiation of autophagy in neurons stressed by oligomeric beta-amyloid peptide., Department of Pathophysiology, Tongji College of Medicine, Huazhong University of Science and Technology, Wuhan, China. 2012. |
| Chang R.C.C., Editorial Board Member, American Journal of Alzheimer's Disease and Other Dementia. 2011. |
| Chang R.C.C., Editorial Board Member, Automated Experimentation. 2011. |
| Chang R.C.C., Editorial Board Member, Chinese Medicine. 2011. |
| Chang R.C.C., Editorial Board Member, Dataset Paper in Neuroscience. 2011. |
| Chang R.C.C., Editorial Board Member, Neural Regeneration Research. 2011. |
| Chang R.C.C., Editorial Board Member, The Open Enzyme Inhibition Journal. 2011. |
| Chang R.C.C., Editorial Board Memeber, Automated Experimentation. 2011. |
| Chang R.C.C., Editorial Board Memeber, International Journal of Clinical and Experimental Medicine. 2011. |
| Chang R.C.C., Editorial Board member, American Journal of Alzheimer's Disease and Other Dementias. 2011. |
| Chang R.C.C., Gouqizi (Wolfberry) as an example to promote the value of Chinese medicinal herbs development, Colloquium in the Development of Valuable Chinese Medicinal Herbs, Wuhan, China. 2012. |
| Chang R.C.C., Handling Associate Editor, Journal of Alzheimer's Disease. 2011. |
| Chang R.C.C., How do endoplasmic reticulum and mitochondria respond when neurons are in the emergency room?, The Fifth International Congress of the Asian Society Against Dementia - Action, Strategies & Developments, Hong Kong. 2011. |
| Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., How do endoplasmic reticulum and mitochondria respond when neurons are in the emergency room?, The Fifth International Congress of the Asian Society Against Dementia - Action, Strategies and Developments, Hong Kong, Nov. 5-6, 2011. 35. |
| Chang R.C.C., Modulation of neuroimmune responses to protect retinal ganglion cells in glaucoma. Can we open a new gate for therapeutic intervention?, Mini-symposium on Vision and Ophthalmology, JNU-HKU Joint Laboratory of Brain Function and Health, Ji-Nang University, Guangzhou, China. 2012. |
| Chang R.C.C., Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring. Croatia, InTech, 2011, 1-558. |
| Chang R.C.C., Potential of using anti-aging Wolfberry (Gouqizi) to prevent aging-related neurodegeneration. What do we know so far?, The First Symposium on Integrative Western and Chinese Medicine in Neurological Disorders, Beijing, China. 2011. |
| Chang R.C.C., Session Chair, Frontiers in Biomedical Sciences. 2011. |
| Chang R.C.C., Session Panelist for Mechanisms Study (Metabolic, Neural Diseases and Aging Process), The 10th Meeting of Consortium for Globalization of Chinese Medicine. 2011. |
| Chang R.C.C., The Open Enzyme Inhibition Journal. 2011, 1. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., So K.F. and Chang R.C.C., Immune modulation in glaucoma - can manipulation of microglial activation help?, In: Martina Kofronova and Tomas Kubena, The Mystery of Glaucoma. Croatia, InTech, 2011, Chapter 14: 257-268. |
| Chiu K., Chan T.F., Wu A.G.K., Leung I.Y.P., So K.F. and Chang R.C.C., Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?, Age. 2012, 34: 633-649. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64. |
| Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Ho Y.S., Poon C.H., Chan T.F. and Chang R.C.C., From small to big molecules: How do we prevent and delay the progression of age-related neurodegeneration?, Current Pharmaceutical Design. 2012, 18: 15-26. |
| Ho Y.S., Chiu K., Hung H.L., So K.F. and Chang R.C.C., Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?, In: Akhlaq A. Farooqui and Tahira Farooqui, Phytochemicals and Human Health. New York, Nova Science Publishers, Inc., 2011, Chapter VI: 157-186. |
| Ho Y.S., So K.F. and Chang R.C.C., Using Lycium Barbarum (Gouqizi) as an example to explain the holistic concept of anti-aging chinese medical herbs, The 10th Meeting of Consortium for Globalizaiton of Chinese Medicine, August 26-28, 2011, Shanghia, China. 2011, 104. |
| Hung H.L., Cheung Y.T., Wuwongse S., Zhang Q., Ho Y.S. and Chang R.C.C., Mitochondrial dynamics in Alzheimer's disease: When shape matters, 7th International Symposium on Healthy Aging. 2012, 50. |
| Lam C.S., Tipoe G.L., Chang R.C.C., Cheung K.H. and Fung M.L., Protective effect of Lycium barbarum polysaccharides against rat hippocampal injury induced by chronic intermittent hypoxia, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P31, 3/2012. |
| Lau C.F., Ho Y.S., Poon C.H., Wuwongse S., Chu L.W. and Chang R.C.C., Testosterone attenuated pre-synaptic disrutpion in beta-amyloid-treated rat hippocampal neurons, 7th International Symposium on Healthy Aging. 2012, 67. |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-fertility effect of Wolfberry polysaccharide against sexual inhibition caused by glucocorticoid, which is associated with adult neurogenesis, , The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, Ching. 2011, 106. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-sexual effect of polysaccharide from Wolfberry is associated with adult neurogenesis, 7th International Symposium on Healthy Aging. 2012, 60. |
| Li H., Chang R.C.C. and So K.F., Effects of Lycium Barbarum on the survival o retinal ganglion cells after optic nerve injuries, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 160. |
| Li H., Liang Y., Chiu K., Yuan Q. and Chang R.C.C., Effects of Lycium Barbarum on the survival of retinal ganglion cells after optic nerve injuries, 7th International Symposium on Healthy Aging. 2012, 71. |
| Li H.Y., Chang R.C.C. and So K.F., Effects of the extract from wolfberry on the survival of retinal ganglion cells after optic nerve transection, 8th IBRO, Itay, 2011. B363. |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Poon C.H., Ho Y.S. and Chang R.C.C., Mixed cytokines treatment causes neurodegeneraton-like changes in neurons and glia, 7th International Symposium on Healthy Aging. 2012, 65. |
| So K.F. and Chang R.C.C., Using Lycium barbarum (Gouqizi) as an example to explain the holistic concept of anti-aging Chinese medical herbs., Proceeding of The 10th Metting of Consortium for Globilization of Chinese Medicine.. 2011, p104. |
| Tsang A.W., Wong G.T.H., Wuwongse S., Ho Y.S., Law A.C.K., Chang R.C.C. and Wuwongse S., Corticosterone-induced changes to tau protein in a model of depression, 7th International Symposium on Healthy Aging. 2012, 64. |
| Wong G.T.H., Wuwongse S., Hung H.L., Law A.C.K., Chang R.C.C. and Wuwongse S., Similarity of dendritic regression in depression and Alzheimer's disease, 7th International Symposium on Healthy Aging. 2012, 61. |
| Wong T.H.G., Wuwongse S., Chang R.C.C. and Law A.C.K., Synaptic and cytoskeletal changes in Alzheimer's disease and depression, 12th International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. 2012, pp195. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Law A.C.K. and Chang R.C.C., Synaptic dysfunction in Alzheimer's disease and depression, 7th International Symposium on Healthy Aging. 2012, 67. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Chang R.C.C. and Law A., Synaptic vesicle protein pathology in Alzheimer's disease and depression, Alzheimer's and Dementia 2011. 7(4) Supp 1: S587. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum polysaccharides protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke, PLoS ONE. 2012, 7: e33596. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of Lycium Barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, 7th International Symposium on Healthy Aging. 2012, 60. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong 2012. |
| Yang D., Li S.Y., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Society for Neuroscience 2011. |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Zhang E., Chang R.C.C. and So K.F., Promotion of neurogenesis by Gouqizi (Wolfberry) in experimental depression, The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, China. 2011, 106. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of endoplasmic reticulum triggered slective autophagic degradation in primary cultures of rat hippocampal neurons stressed by oligomeric Ab, 7th International Symposium on Healthy Aging. 2012, 59. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of the endoplasmic reticulum triggered by oligomeric beta-amyloid peptides could initiate autophagy, Alzheimer's and Dementia. 2011, 794) Suppl. 1: S406. |
| Zhu Q., Zhang Q., Lau C.F., Chao J., Sun Z., Chang R.C.C., Chen F. and Wang M., In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple, Food Chemistry. 2012, 135: 1762-1768. |
| Researcher : Chau RMW |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 The Possible Mechanism of Action for Quinacrine Interacting the Scrapie Protein in Prion Disease |
| Investigator(s): | Chau RMW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Researcher : Chen AYS |
| Project Title: | Study of the role of polyol pathway activation the impaired nerve regeneration in diabetes |
| Investigator(s): | Chen AYS, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| List of Research Outputs |
| Hung K.L., Chen A.Y.S., Chen S.M.Y., Tai W.L., Chung S.K. and Cheung C.W., Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalininjection., The Twelfth Conference on Endothelin, 11-14 September 2011, Cambridge, U.K. 2011. |
| Researcher : Chen J |
| List of Research Outputs |
| Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., RNF169 antagonises the ubiquitin-dependentsignaling cascade at sites of DNA damage (Awarded the third place of poster abstracts) , The Chinese Biological Investigators Society & 4th International Conference on Biomedical and Environmental Sciences & Technology(icBEST-2012) . 2012. |
| Researcher : Chen Y |
| List of Research Outputs |
| Chen Y., Tai A. and Chung S.K., Epac1 is involved in beta-adrenergic induction of brown adipose tissue and white adipose tissue., The 16th Research Postgraduate Symposium, entitled Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose tissue in White Adipose Tissue. 2011. |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012. |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012. |
| Researcher : Cheng L |
| List of Research Outputs |
| Cheng L., The role of exchange protein directly activated by cyclic AMP 2-deficiency in ischemic stroke. 2011, 131 pages. |
| Researcher : Cheung A |
| Project Title: | Synergistic effect and molecular mechanisms of green tea (EGCG) and vitamin C in the prevention of esophageal cancer |
| Investigator(s): | Cheung A, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2012 |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Impact of replication fork stalling on centromeric instability |
| Investigator(s): | Cheung A, Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Completion Date: | 01/2012 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Cheung A., Applied Immunohistochemistry & Molecular Morphology, Editorial Board, Lippincott Williams & Wilkins, 2012. |
| Cheung A., The Open Pathology Journal, Editorial Board, Bentham Open, 2012. |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Li B., Li J., Tsao G.S.W. and Cheung A., PI3K/AKT pathway as a therapeutic target in human esophageal cancer, 21st Asia Pacific Cancer Conference 2011. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis, In: Proceedings of the American Association for Cancer Research; 2012 March 31 - April 4; Chicago, IL. Philadelphia (PA): AACR. 2012, Abstract nr 4361. |
| Researcher : Cheung A. |
| Project Title: | Synergistic effect and molecular mechanisms of green tea (EGCG) and vitamin C in the prevention of esophageal cancer |
| Investigator(s): | Cheung A, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2012 |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Impact of replication fork stalling on centromeric instability |
| Investigator(s): | Cheung A, Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Completion Date: | 01/2012 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Cheung ALM |
| Project Title: | Synergistic effect and molecular mechanisms of green tea (EGCG) and vitamin C in the prevention of esophageal cancer |
| Investigator(s): | Cheung A, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2012 |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Impact of replication fork stalling on centromeric instability |
| Investigator(s): | Cheung A, Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Completion Date: | 01/2012 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Cheung YT |
| List of Research Outputs |
| Hung H.L., Cheung Y.T., Wuwongse S., Zhang Q., Ho Y.S. and Chang R.C.C., Mitochondrial dynamics in Alzheimer's disease: When shape matters, 7th International Symposium on Healthy Aging. 2012, 50. |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Researcher : Ching Y.P. |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2007 |
| Project Title: | The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2009 |
| Completion Date: | 12/2011 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Project Title: | Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Characterisation of the roles of LKB1 in liver cancer formation |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2012 |
| Project Title: | A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | Regulation of p53 by PAK4 in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2007 |
| Project Title: | The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2009 |
| Completion Date: | 12/2011 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Project Title: | Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Characterisation of the roles of LKB1 in liver cancer formation |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2012 |
| Project Title: | A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | Regulation of p53 by PAK4 in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Ching Y.P., PAK in hepatocellular carcinoma metastasis, Symposium of State Key Laboratory for Liver Research, Sept. 2011 Hong Kong. 2011. |
| Ching Y.P., PAKs in hepatocellular carcinoma, Frontier in Biomedical Research 2011 The University of Hong Kong, Dec. 2011 Hong Kong. 2011. |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Mak W.Y.G. and Ching Y.P., CDK5RAP3 inhibits neuronal differentiation via downregulation of CDK5 activator, 5th Annual Exciting Biologies meeting “Cellular development: Biology at the interface” Kobe, Japan, Sept 2011 . 2011. |
| Tang V.H.M., Siu Y.T., Chan C.P., Ching Y.P., Kok K.H. and Jin D., LKB1 tumor suppressor is a negative regulator of Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats, 13th SCBA International Symposium. Society of Chinese Bioscientists in America (SCBA). Guangzhou, China. 2011. |
| Wang N., Feng Y., Lau E.P., Tsang C.M., Ching Y.P., Man K., Tong Y., Nagamatsu T., Su W. and Tsao G.S.W., F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration., Integrate Cancer Therapy. 2011. |
| Wong L.L.Y., Lam I.P.Y., Wong T.Y.N., Lai W.L., Zhou Y., Hung W.Y. and Ching Y.P., An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma, AACR, March, 2012. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2012, DOI 10.1007/s00394-012-0301-0. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Xiao J., Ching Y.P., Fung M.L. and Tipoe G.L., The protective mechanisms of Lycium Barbarum polysaccharides in non-alcoholic fatty liver disease, 16th Research Postgraduate Symposium, HKU, P2.24, 12/2011. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xu Y., Ching Y.P., Zhou Y., Chiu J. and He Q.Y., Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells, Journal of Proteomics. 2011, in press. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Researcher : Chiu J |
| List of Research Outputs |
| Xu Y., Ching Y.P., Zhou Y., Chiu J. and He Q.Y., Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells, Journal of Proteomics. 2011, in press. |
| Researcher : Chiu K |
| Project Title: | Significance of amyloid precursor protein processing and amyloid beta deposition in the retinal neurodegeneration: do ER-stress signaling or mitochondrial stress signaling involved? |
| Investigator(s): | Chiu K, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Project Title: | The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) in confunction with The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) The 1st Cross-Strait Biotechnology Forum Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells |
| Investigator(s): | Chiu K |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2012 |
| Completion Date: | 04/2012 |
| List of Research Outputs |
| Chan T.F., Chiu K., Lok C.K.M., Ho W.L., So K.F. and Chang R.C.C., Morphometric analyses of retinal sections, Journal of Visualized Experiments. 2012, 60: pii 3377 doi: 10.3791/3377. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., So K.F. and Chang R.C.C., Immune modulation in glaucoma - can manipulation of microglial activation help?, In: Martina Kofronova and Tomas Kubena, The Mystery of Glaucoma. Croatia, InTech, 2011, Chapter 14: 257-268. |
| Chiu K., Chan T.F., Wu A.G.K., Leung I.Y.P., So K.F. and Chang R.C.C., Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?, Age. 2012, 34: 633-649. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752. |
| Ho Y.S., Chiu K., Hung H.L., So K.F. and Chang R.C.C., Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?, In: Akhlaq A. Farooqui and Tahira Farooqui, Phytochemicals and Human Health. New York, Nova Science Publishers, Inc., 2011, Chapter VI: 157-186. |
| Li H., Liang Y., Chiu K., Yuan Q. and Chang R.C.C., Effects of Lycium Barbarum on the survival of retinal ganglion cells after optic nerve injuries, 7th International Symposium on Healthy Aging. 2012, 71. |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Researcher : Chung SK |
| Project Title: | Role of Epac1, cAMP-regulated guanine nucleotide exchange factor 1, in blood brain barrier maintenance, infarct and neurological deficits during ischemia/reperfusion injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Role of transcription factor NFAT5 target gene aldose reductase in inflammation, edema and oxidative stress after spinal cord injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2010 |
| Project Title: | Role of STARD13, Rho GTPase activating protein, in blood-brain barrier maintenance, infarct and dementia associated with brain injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2011 |
| Completion Date: | 05/2012 |
| Project Title: | The role of exchange protein directly activated by cAMP Epac in diabetic painless and painful neuropathy |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Baretella O.M., Li F.Y.L., Chung S.K. and Vanhoutte P.M.G.R., Reduction of contractions to phenylephrine by L-NAME in the carotid artery of mice with endothelial overexpression of endothelin-1, Experimental Biology 2012, April 21 - 25, 2012, San Diego, CA . 2012. |
| Chen Y., Tai A. and Chung S.K., Epac1 is involved in beta-adrenergic induction of brown adipose tissue and white adipose tissue., The 16th Research Postgraduate Symposium, entitled Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose tissue in White Adipose Tissue. 2011. |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012. |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012. |
| Cheung S.S.F., Leung J.W.C., Lam A.K.M., Lam K.S.L., Chung S.S.M., Lo A.C.Y. and Chung S.K., Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina, PLoS One . 2011, 6(10: e26184. |
| Chung S.K., Diabetes and Alzheimer's disease, Cardiovascular and Metaabolic Disease Center, Inje University college of Medicine, Busan, Korea. 2012. |
| Chung S.K., Genetically Manipulated Mouse Models for Human Diseases: Diabetes and its Complications, "COOL" lecture at Inje University College of Medicine, Busan, Korea. 2011. |
| Chung S.K., Genetically Manipulated Mouse Models for Human Diseases: Diabetes and its Complications, 14th Korean Society of Biochemistry and Molecular Biology meeting & BEST MISO, Busan, Korea. 2011. |
| Chung S.K., Genetically Manipulated Mouse Models for Human Diseases: Vascular Complications and Dementia, The 6th International Conference of the Asian Society Against Dementia (ASAD) and 17th Malaysian Conference on Psychological Medicine, Sheraton Imperial Kuala Lumpur Hotel. 2012. |
| Chung S.K., Genetically manipulated mouse models for diabetes, The 2nd International Diabetes, Obesity and Cardiovascular Disease, Hong Kong. 2011. |
| Chung S.K., Genetically manipulated mouse models for human diseases: diabetes and its complications, Center for Endocrin and Metabolic Diseases, Chungnam National University Hospital, Daejeon, Korea. 2012. |
| Chung S.K., Molecular Basis for Painful and Painless Neuropathy, Pain Genetics Symposium: From Basic Science to Clinical Applications, The University of Hong Kong, Hong Kong. 2012. |
| Chung S.K., Therapeutic Modalities to Correct Mitochondrial Dysfunction-KSMCB Mitochondrial section and KSMRM joint symposium, 25th Spring Congress of Korean Diabetes Association, Hotel Inter-Burgo, Daegu, Korea. 2012. |
| Durairajan S.S.K., Liu L., Lu J.H., Chen L.L., Yuan Q., Chung S.K., Huang L., Li X.S., Huang J.D. and Li M., Berberine ameliorates b-amyloid pathology, gliosis and cognitive impairment in an Alzheimer's disease transgenic mouse model , Neurobiology of Aging. 2012. |
| Feng Q., Chung S.K. and So K.F., Non-vascular NG2 expressing cells in adult mouse retina, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 80. |
| Fu Z., Li S.Y., Wong D.S.H., Chung S.K. and Lo A.C.Y., Aldose reductase deficiency protects the retinal neurons in a mouse model of retinopathy of prematurity, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong 2012. |
| Fu Z., Li S.Y., Wong D.S.H., Chung S.K. and Lo A.C.Y., Genetic Deletion or Pharmacological Inhibition of Aldose Reductase Protects the Retina in a Mouse Model of Ischemia induced Retinopathy, ARVO 2012 Annual Meeting. 2012. |
| Gu Y., Zheng G., Xu M., Li Y., Chen X., Zhu W., Tong Y., Chung S.K., Liu K.J. and Shen J., Caveolin-1 regulates nitric oxide mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury, Journal of Neurochemistry. 2012, 120(1): 147-156. |
| Hung K.L., Chen A.Y.S., Chen S.M.Y., Tai W.L., Chung S.K. and Cheung C.W., Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalininjection., The Twelfth Conference on Endothelin, 11-14 September 2011, Cambridge, U.K. 2011. |
| Hung K.L., Lai K.W., Lo A.C.Y., Lamb B.T., Chan K.C., Wu E.X., Cheung C.W., Chung S.S.M. and Chung S.K., Selective astrocytic ET-1 over-expression exacerbates cognitive deficit and cerebrovascular amyloid accumulation in animal models of stroke and Alzheimer's disease, The Twelfth Conference on Endothelin, 11-14 Sept 2011, Cambridge, UK. 2011. |
| Leung J.W.C., Wong W.T., Koon H.W., Mo F.M., Tam S., Huang Y., Vanhoutte P.M.G.R., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity, PLoS One. 2011, 6:11: 1-8. |
| Li Y., Luo J., Zheng G., Fu S., Wang T.T., Zeng H.P., So K.F., Chung S.K., Tong Y. and Shen J., Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway, PLoS One. 2011, 6(8): 22901. |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Mi X., Zhang X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, IOVS Papers in Press. 2012. |
| Tirrell L.S. and Chung S.K., Knockout of RhoGTPase Activating Protein DLC2 in Mice Causes Altered Pain Response and Impaired Glucose Tolerance, Anatomy Postgraduate Symposium. 2012. |
| Zhang L., Chung S.K. and Chow B.K.C., Knockout of Secretin in Purkinje Cells Changes Mouse Motor and Balance Behaviors, Endocrine Society Annual Meeting, ENDO 2012, Houston, TX, USA. 2012. |
| Researcher : Deng W |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Researcher : Deng W. |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Researcher : Dong S |
| List of Research Outputs |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Researcher : Ellis-Behnke RG |
| Project Title: | The ADME of Self-assembling Nanomaterials |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Incorporation Dynamics of Additives and Self-assembly peptides (SAPs) at Nanoscale for Central Nervous System (CNS) Regeneration |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Self-assembling Peptides (SAPs) at Nanoscale for Blood Preservation |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2009 |
| Researcher : Feng Q |
| List of Research Outputs |
| Feng Q., Chung S.K. and So K.F., Non-vascular NG2 expressing cells in adult mouse retina, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 80. |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Researcher : Feng W |
| List of Research Outputs |
| Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., RNF169 antagonises the ubiquitin-dependentsignaling cascade at sites of DNA damage (Awarded the third place of poster abstracts) , The Chinese Biological Investigators Society & 4th International Conference on Biomedical and Environmental Sciences & Technology(icBEST-2012) . 2012. |
| Researcher : Fu Z |
| List of Research Outputs |
| Fu Z., Li S.Y., Wong D.S.H., Chung S.K. and Lo A.C.Y., Aldose reductase deficiency protects the retinal neurons in a mouse model of retinopathy of prematurity, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong 2012. |
| Fu Z., Li S.Y., Wong D.S.H., Chung S.K. and Lo A.C.Y., Genetic Deletion or Pharmacological Inhibition of Aldose Reductase Protects the Retina in a Mouse Model of Ischemia induced Retinopathy, ARVO 2012 Annual Meeting. 2012. |
| Li S.Y., Yang D., Fu Z., Woo T., Wong D.S.H. and Lo A.C.Y., Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke, Neurobiology of Disease. 2012, 45: 624-32. |
| Researcher : Fung MY |
| List of Research Outputs |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-fertility effect of Wolfberry polysaccharide against sexual inhibition caused by glucocorticoid, which is associated with adult neurogenesis, , The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, Ching. 2011, 106. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-sexual effect of polysaccharide from Wolfberry is associated with adult neurogenesis, 7th International Symposium on Healthy Aging. 2012, 60. |
| Researcher : Guo A |
| List of Research Outputs |
| Guo A., Therapeutic potentials of oligodendrocyte precursors in the animal model of multiple sclerosis. 2011, 94 pages. |
| Researcher : Hau PM |
| Project Title: | The importance of ATM DNA damage signaling in Epstein-Barr virus lytic replication in infected epithelial cells |
| Investigator(s): | Hau PM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2011 |
| List of Research Outputs |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Hau P.M., Yip Y.L., Huen M.S.Y. and Tsao G.S.W., Loss of DNp63a promotes mitotic exit in epithelial cells, FEBS Letters. 2011. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Researcher : Ho YS |
| Project Title: | Investigating the potential of anti-inflammatory cytokine Interleukin-10 to attenuate synaptic degeneration in systemic inflammation-induced depression |
| Investigator(s): | Ho YS, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 08/2012 |
| List of Research Outputs |
| Chang R.C.C., Zhang Q., Hung H.L., Ho Y.S. and Wuwongse S., Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric b-amyloid peptide-treated neurons, Society for Neuroscience 2011. Program#/Poster#: 637.10. |
| Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., How do endoplasmic reticulum and mitochondria respond when neurons are in the emergency room?, The Fifth International Congress of the Asian Society Against Dementia - Action, Strategies and Developments, Hong Kong, Nov. 5-6, 2011. 35. |
| Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64. |
| Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Ho Y.S., Poon C.H., Chan T.F. and Chang R.C.C., From small to big molecules: How do we prevent and delay the progression of age-related neurodegeneration?, Current Pharmaceutical Design. 2012, 18: 15-26. |
| Ho Y.S., Chiu K., Hung H.L., So K.F. and Chang R.C.C., Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?, In: Akhlaq A. Farooqui and Tahira Farooqui, Phytochemicals and Human Health. New York, Nova Science Publishers, Inc., 2011, Chapter VI: 157-186. |
| Ho Y.S., So K.F. and Chang R.C.C., Using Lycium Barbarum (Gouqizi) as an example to explain the holistic concept of anti-aging chinese medical herbs, The 10th Meeting of Consortium for Globalizaiton of Chinese Medicine, August 26-28, 2011, Shanghia, China. 2011, 104. |
| Hung H.L., Cheung Y.T., Wuwongse S., Zhang Q., Ho Y.S. and Chang R.C.C., Mitochondrial dynamics in Alzheimer's disease: When shape matters, 7th International Symposium on Healthy Aging. 2012, 50. |
| Lau C.F., Ho Y.S., Poon C.H., Wuwongse S., Chu L.W. and Chang R.C.C., Testosterone attenuated pre-synaptic disrutpion in beta-amyloid-treated rat hippocampal neurons, 7th International Symposium on Healthy Aging. 2012, 67. |
| Poon C.H., Ho Y.S. and Chang R.C.C., Mixed cytokines treatment causes neurodegeneraton-like changes in neurons and glia, 7th International Symposium on Healthy Aging. 2012, 65. |
| Tsang A.W., Wong G.T.H., Wuwongse S., Ho Y.S., Law A.C.K., Chang R.C.C. and Wuwongse S., Corticosterone-induced changes to tau protein in a model of depression, 7th International Symposium on Healthy Aging. 2012, 64. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Law A.C.K. and Chang R.C.C., Synaptic dysfunction in Alzheimer's disease and depression, 7th International Symposium on Healthy Aging. 2012, 67. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Chang R.C.C. and Law A., Synaptic vesicle protein pathology in Alzheimer's disease and depression, Alzheimer's and Dementia 2011. 7(4) Supp 1: S587. |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of endoplasmic reticulum triggered slective autophagic degradation in primary cultures of rat hippocampal neurons stressed by oligomeric Ab, 7th International Symposium on Healthy Aging. 2012, 59. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of the endoplasmic reticulum triggered by oligomeric beta-amyloid peptides could initiate autophagy, Alzheimer's and Dementia. 2011, 794) Suppl. 1: S406. |
| Researcher : Huen M.S.Y. |
| Project Title: | Monitoring DNA damage Using a Novel Fluorescence-based Biosensor: A platform for Drug Discovery and Genotoxic Evaluations |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 09/2010 |
| Completion Date: | 08/2011 |
| Project Title: | Characterization of USP34, a novel ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Completion Date: | 07/2012 |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling. |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Huen MSY |
| Project Title: | Monitoring DNA damage Using a Novel Fluorescence-based Biosensor: A platform for Drug Discovery and Genotoxic Evaluations |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 09/2010 |
| Completion Date: | 08/2011 |
| Project Title: | Characterization of USP34, a novel ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Completion Date: | 07/2012 |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling. |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., RNF169 antagonises the ubiquitin-dependentsignaling cascade at sites of DNA damage (Awarded the third place of poster abstracts) , The Chinese Biological Investigators Society & 4th International Conference on Biomedical and Environmental Sciences & Technology(icBEST-2012) . 2012. |
| Hau P.M., Yip Y.L., Huen M.S.Y. and Tsao G.S.W., Loss of DNp63a promotes mitotic exit in epithelial cells, FEBS Letters. 2011. |
| Huen M.S.Y., Regulatory Ubiquitylation in DNA Damage Signaling and Repair, The University of Science and Technology of China. 2011. |
| Leung J.W., Wang Y., Fong K.W., Huen M.S.Y., Li L. and Chen J., A UBZ domain-containing protein FAAP20 binds to FANCA and participates in interstrand crosslink repair, PNAS. 2012, In Press. |
| Liu J., Ouyang M., Jiang J., Mu P., Wu J., Yang Q., Zhang C., Xu W., Wang L., Huen M.S.Y. and Deng Y., Mequindox induced cellular DNA damage via generation of reactive oxygen species., Mutat Res. 2012, 741(1-2): 70-5. |
| Liu T., Chen H., Kim H., Huen M.S.Y., Chen J. and Huang J., RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage., DNA Repair. 2011, In Press. |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Rai R., Li J.M., Zheng H., Lok T.M., Deng Y., Huen M.S.Y., Chen J., Jin J. and Chang S., The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection., Nat Struct Mol Biol. 2011, 18(12): 1400-7. |
| Shao Z., Li F., Sy M.H., Yan W., Zhang Z., Gong D., Wen B., Huen M.S.Y., Gong Q., Wu J. and Shi Y., Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure., J Struct Biol. 2011, In Press. |
| Researcher : Hugon J |
| Project Title: | Society for Neuroscience 30th Annual Meeting Tau Phosphorylation during neuronal Apoptosis Induced by NMDA Receptor Blockade: an in Vivo Study |
| Investigator(s): | Hugon J |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Researcher : Hung HL |
| List of Research Outputs |
| Chang R.C.C., Zhang Q., Hung H.L., Ho Y.S. and Wuwongse S., Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric b-amyloid peptide-treated neurons, Society for Neuroscience 2011. Program#/Poster#: 637.10. |
| Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., How do endoplasmic reticulum and mitochondria respond when neurons are in the emergency room?, The Fifth International Congress of the Asian Society Against Dementia - Action, Strategies and Developments, Hong Kong, Nov. 5-6, 2011. 35. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Ho Y.S., Chiu K., Hung H.L., So K.F. and Chang R.C.C., Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?, In: Akhlaq A. Farooqui and Tahira Farooqui, Phytochemicals and Human Health. New York, Nova Science Publishers, Inc., 2011, Chapter VI: 157-186. |
| Hung H.L., Characterization of Mitochondrial Morphology and Dynamics in Neurodegeneration. 2012, 197. |
| Hung H.L., Cheung Y.T., Wuwongse S., Zhang Q., Ho Y.S. and Chang R.C.C., Mitochondrial dynamics in Alzheimer's disease: When shape matters, 7th International Symposium on Healthy Aging. 2012, 50. |
| Wong G.T.H., Wuwongse S., Hung H.L., Law A.C.K., Chang R.C.C. and Wuwongse S., Similarity of dendritic regression in depression and Alzheimer's disease, 7th International Symposium on Healthy Aging. 2012, 61. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Law A.C.K. and Chang R.C.C., Synaptic dysfunction in Alzheimer's disease and depression, 7th International Symposium on Healthy Aging. 2012, 67. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Chang R.C.C. and Law A., Synaptic vesicle protein pathology in Alzheimer's disease and depression, Alzheimer's and Dementia 2011. 7(4) Supp 1: S587. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of endoplasmic reticulum triggered slective autophagic degradation in primary cultures of rat hippocampal neurons stressed by oligomeric Ab, 7th International Symposium on Healthy Aging. 2012, 59. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of the endoplasmic reticulum triggered by oligomeric beta-amyloid peptides could initiate autophagy, Alzheimer's and Dementia. 2011, 794) Suppl. 1: S406. |
| Researcher : Hung WY |
| List of Research Outputs |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Wong L.L.Y., Lam I.P.Y., Wong T.Y.N., Lai W.L., Zhou Y., Hung W.Y. and Ching Y.P., An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma, AACR, March, 2012. |
| Researcher : Jiang J |
| List of Research Outputs |
| Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., RNF169 antagonises the ubiquitin-dependentsignaling cascade at sites of DNA damage (Awarded the third place of poster abstracts) , The Chinese Biological Investigators Society & 4th International Conference on Biomedical and Environmental Sciences & Technology(icBEST-2012) . 2012. |
| Researcher : Kai KLA |
| List of Research Outputs |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012. |
| Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012. |
| Researcher : Kong LHM |
| List of Research Outputs |
| Liao S., Kong L.H.M., Tang F. and O W.S., Possible functions of adrenomedullin from the seminal fluid in the female reproductive tract of the rat, Informa Healthcare. 2012, 58: 306-312. |
| Researcher : Lai KW |
| List of Research Outputs |
| Hung K.L., Lai K.W., Lo A.C.Y., Lamb B.T., Chan K.C., Wu E.X., Cheung C.W., Chung S.S.M. and Chung S.K., Selective astrocytic ET-1 over-expression exacerbates cognitive deficit and cerebrovascular amyloid accumulation in animal models of stroke and Alzheimer's disease, The Twelfth Conference on Endothelin, 11-14 Sept 2011, Cambridge, UK. 2011. |
| Researcher : Lai SW |
| List of Research Outputs |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Researcher : Lai WL |
| Project Title: | An investigation on the tumour suppressor activity of Tax1 binding protein 2 in hepatocellular carcinoma |
| Investigator(s): | Lai WL, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 08/2012 |
| List of Research Outputs |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Wong L.L.Y., Lam I.P.Y., Wong T.Y.N., Lai W.L., Zhou Y., Hung W.Y. and Ching Y.P., An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma, AACR, March, 2012. |
| Researcher : Lam PY |
| List of Research Outputs |
| Lee V.H.Y., Lam P.Y., Choi H.S., Chow B.K.C. and Lee T.O., The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation., PLoS ONE. 2012, 7(6): e39913. |
| Researcher : Lau CF |
| List of Research Outputs |
| Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64. |
| Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Lau C.F., Ho Y.S., Poon C.H., Wuwongse S., Chu L.W. and Chang R.C.C., Testosterone attenuated pre-synaptic disrutpion in beta-amyloid-treated rat hippocampal neurons, 7th International Symposium on Healthy Aging. 2012, 67. |
| Zhu Q., Zhang Q., Lau C.F., Chao J., Sun Z., Chang R.C.C., Chen F. and Wang M., In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple, Food Chemistry. 2012, 135: 1762-1768. |
| Researcher : Lau JYB |
| List of Research Outputs |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Researcher : Lau KLK |
| List of Research Outputs |
| Tso H.W., Yim L.Y., Lau K.L.K., Li R.A. and Chan C.W.Y., Distinct immunomodulatory effect of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells, Re-engineering Regenerative Medicine 2012. 2011. |
| Researcher : Lau MY |
| List of Research Outputs |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Researcher : Lau WM |
| Project Title: | Are neurogenesis and gliogenesis involved in the neurobiology of specific phobia? |
| Investigator(s): | Lau WM, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 11/2012 |
| List of Research Outputs |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-fertility effect of Wolfberry polysaccharide against sexual inhibition caused by glucocorticoid, which is associated with adult neurogenesis, , The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, Ching. 2011, 106. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-sexual effect of polysaccharide from Wolfberry is associated with adult neurogenesis, 7th International Symposium on Healthy Aging. 2012, 60. |
| Lee C.D., Yau S.Y., Lau W.M. and So K.F., Exercise improves motor functions in relation to increased cell proliferation in layer 1 of the motor cortex, 16th Research Postgraduate symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 85. |
| Yau S.Y., Lau W.M. and So K.F., Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress, Cell Transplantation . 2011, 20: P99-111. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Researcher : Lee CD |
| List of Research Outputs |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-fertility effect of Wolfberry polysaccharide against sexual inhibition caused by glucocorticoid, which is associated with adult neurogenesis, , The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, Ching. 2011, 106. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-sexual effect of polysaccharide from Wolfberry is associated with adult neurogenesis, 7th International Symposium on Healthy Aging. 2012, 60. |
| Lee C.D., Yau S.Y., Lau W.M. and So K.F., Exercise improves motor functions in relation to increased cell proliferation in layer 1 of the motor cortex, 16th Research Postgraduate symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 85. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24. |
| Researcher : Lee CW |
| List of Research Outputs |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Researcher : Lee VWH |
| List of Research Outputs |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Researcher : Leong VYL |
| List of Research Outputs |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Researcher : Leung JWC |
| List of Research Outputs |
| Cheung S.S.F., Leung J.W.C., Lam A.K.M., Lam K.S.L., Chung S.S.M., Lo A.C.Y. and Chung S.K., Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina, PLoS One . 2011, 6(10: e26184. |
| Leung J.W.C., Wong W.T., Koon H.W., Mo F.M., Tam S., Huang Y., Vanhoutte P.M.G.R., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity, PLoS One. 2011, 6:11: 1-8. |
| Researcher : Li B |
| Project Title: | PI3K/AKT pathway as a therapeutic target in human esophageal cancer |
| Investigator(s): | Li B, Cheung A, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2010 |
| Completion Date: | 04/2012 |
| Project Title: | American Association for Cancer Research Annual Meeting 2012 Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis |
| Investigator(s): | Li B |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2012 |
| Completion Date: | 04/2012 |
| List of Research Outputs |
| Li B., Li J., Tsao G.S.W. and Cheung A., PI3K/AKT pathway as a therapeutic target in human esophageal cancer, 21st Asia Pacific Cancer Conference 2011. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis, In: Proceedings of the American Association for Cancer Research; 2012 March 31 - April 4; Chicago, IL. Philadelphia (PA): AACR. 2012, Abstract nr 4361. |
| Researcher : Li H |
| List of Research Outputs |
| Li H., Chang R.C.C. and So K.F., Effects of Lycium Barbarum on the survival o retinal ganglion cells after optic nerve injuries, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 160. |
| Researcher : Li J |
| List of Research Outputs |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Li B., Li J., Tsao G.S.W. and Cheung A., PI3K/AKT pathway as a therapeutic target in human esophageal cancer, 21st Asia Pacific Cancer Conference 2011. |
| Li J., Role of AMPK signaling in the anti-cancer effects of silibinin in esophageal squamous cell carcinoma. 2011, 64 pages. |
| Researcher : Li J |
| List of Research Outputs |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Li B., Li J., Tsao G.S.W. and Cheung A., PI3K/AKT pathway as a therapeutic target in human esophageal cancer, 21st Asia Pacific Cancer Conference 2011. |
| Li J., Role of AMPK signaling in the anti-cancer effects of silibinin in esophageal squamous cell carcinoma. 2011, 64 pages. |
| Researcher : Liang Y |
| List of Research Outputs |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Li H., Liang Y., Chiu K., Yuan Q. and Chang R.C.C., Effects of Lycium Barbarum on the survival of retinal ganglion cells after optic nerve injuries, 7th International Symposium on Healthy Aging. 2012, 71. |
| Researcher : Liao S |
| List of Research Outputs |
| Liao S., Kong L.H.M., Tang F. and O W.S., Possible functions of adrenomedullin from the seminal fluid in the female reproductive tract of the rat, Informa Healthcare. 2012, 58: 306-312. |
| Liao S., Li R.H.W., Ho J.C.M., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy, Journal of Clinical Endocrinology and Metabolism . Journal of Clinical Endocrinolog and Metabolism, 2012, 97: 2105-2112. |
| O W.S., Liao S., Li R.H.W., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., The role of adrenomedullin in tubal ectopic pregnancy, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 81 Abstract 124. |
| Researcher : Lin B |
| Project Title: | Remodeling of retinal cone bipolar cells in mouse models of rd |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2010 |
| Completion Date: | 01/2012 |
| Project Title: | Restoring visual function after photoreceptor degeneration: ectopic expression of photosensitive proteins in retinal neurons. |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Mechanisms of the Secondary Degeneration of Retinal Cone Photoreceptors in Retinitis Pigmentosa (RP) |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2011 |
| Project Title: | Protection and Restoration of cone photoreceptors by a novel multifunctional drug and its neuroprotective molecular mechanisms in one mouse model of retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2012 |
| Project Title: | 2012 ARVO Annual meeting Long-term preservation of cone photoreceptors by a novel multifunctional drug in a mouse model of human retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2012 |
| Completion Date: | 05/2012 |
| Researcher : Ling MT |
| Project Title: | The regulation and role of Id-1 in prostate cancer progression |
| Investigator(s): | Ling MT, Wong YC, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | The role of EMI1 in prostate carcinogenesis |
| Investigator(s): | Ling MT, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2007 |
| Project Title: | The role of Daxx in chromosome instability and prostate carcinogenesis |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Effect of Tocotrienol in the inhibition of hormone refractory prostate cancer |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 08/2008 |
| List of Research Outputs |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Researcher : Liong EC |
| List of Research Outputs |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Lam S.S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia., XVIIIth ISAC (International Society for Arterial Chemoreception) Conference. 2011. |
| Lam S.Y.S., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, The 18th International Society for Arterial Chemoreception Meeting, Hamilton, Canada, P4.4, 7/2011. |
| Liong E.C., Xiao J., Lau T.Y.H., Nanji A.A. and Tipoe G.L., Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model, Food and Chemical Toxicology. 2012, 50: 861-866. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2012, DOI 10.1007/s00394-012-0301-0. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Researcher : Liu J |
| List of Research Outputs |
| Liu J., The role of exchange protein directly activated by cyclic AMP 1-deficiency in diabetic and ischemic retinopathy. 2012, 116 pages. |
| Researcher : Liu M |
| List of Research Outputs |
| Yip H.K.F. and Liu M., Id2 Expression In The Adult Mouse Subventricular Zone, US Society of Neuroscience Annual Meeting, 2011. |
| Researcher : Liu MHF |
| List of Research Outputs |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Researcher : Liu X |
| List of Research Outputs |
| Liu X., Effects of activated microglia on the properties of neural stem cells in vitro. 2012, 121 pages. |
| Researcher : Lok CKM |
| List of Research Outputs |
| Chan T.F., Chiu K., Lok C.K.M., Ho W.L., So K.F. and Chang R.C.C., Morphometric analyses of retinal sections, Journal of Visualized Experiments. 2012, 60: pii 3377 doi: 10.3791/3377. |
| Researcher : Lok TM |
| List of Research Outputs |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Rai R., Li J.M., Zheng H., Lok T.M., Deng Y., Huen M.S.Y., Chen J., Jin J. and Chang S., The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection., Nat Struct Mol Biol. 2011, 18(12): 1400-7. |
| Researcher : Mak MC |
| List of Research Outputs |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Researcher : Mak WYG |
| List of Research Outputs |
| Mak W.Y.G. and Ching Y.P., CDK5RAP3 inhibits neuronal differentiation via downregulation of CDK5 activator, 5th Annual Exciting Biologies meeting “Cellular development: Biology at the interface” Kobe, Japan, Sept 2011 . 2011. |
| Researcher : Man CWY |
| Project Title: | The polycomb group protein, Bmi-1, induces supernumerary centrosomes and chromosome instability through Id1 in immortalized nasopharyngeal epithelial cells |
| Investigator(s): | Man CWY, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Researcher : Mi X |
| List of Research Outputs |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Mi X., Neurodegeneration and neuroprotection in glaucoma retinopathy-probing the role of endothelin-1, RAGE, Ab and Lycium Barbarum. 2011, 164 pages. |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Mi X., Zhang X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, IOVS Papers in Press. 2012. |
| Researcher : Mi X |
| List of Research Outputs |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Mi X., Neurodegeneration and neuroprotection in glaucoma retinopathy-probing the role of endothelin-1, RAGE, Ab and Lycium Barbarum. 2011, 164 pages. |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Mi X., Zhang X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, IOVS Papers in Press. 2012. |
| Researcher : Nal-Rogier BTM |
| List of Research Outputs |
| Jaume M.D.A., Yip M.S., Cheung C.Y., Leung H.L., Li P.H., Kien F.S., Dutry I.C.A., Callendret B., Escriou N., Altmeyer R.M., Nal-Rogier B.T.M., Daeron M., Bruzzone R. and Peiris J.S.M., Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent FcgR Pathway, Journal of Virology. 2011, 85. |
| Kudelko M.A., Brault J.B., Kwok K.T.H., Pardigon N., Peiris J.S.M., Bruzzone R., Despres P., Nal-Rogier B.T.M. and Wang P., Class II ADP-ribosylation Factors Are Required for Efficient Secretion of Dengue Viruses, The Journal of Biological Chemistry. 2012, 287 (1): 767-777. |
| Researcher : Nian S |
| List of Research Outputs |
| Nian S., Sheridan C., Kearns V., Williams R.L., Wong D.S.H., Vasilev K., Bachhuka A.C.Y., Lo A.C.Y. and Lai W.W.K., Characteristics of rat iris pigment epithelial cells cultured on modified expanded-polytetrafluroethylene (ePTFE) substrates, ARVO 2012 Annual Meeting. 2012. |
| Researcher : Niu C |
| List of Research Outputs |
| Niu C. and Yip H.K.F., Neuroprotective signaling mechanisms of telomerase are regulated by brain-derived neurotrophic factor in rat spinal cord motor neurons, Journal of Neuropathology and Experimental Neurology. 2011, 70(7): 634-652. |
| Researcher : O WS |
| Project Title: | The role of adrenomedullin in human oviduct |
| Investigator(s): | O WS, Tang F |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| Completion Date: | 11/2011 |
| Project Title: | A CASE-CONTROL IN-VITRO STUDY ON THE POSSIBLE ROLE OF ADRENOMEDULLIN AND ENDOTHELIN IN PATHOGENESIS OF TUBAL ECTOPIC PREGNANCY |
| Investigator(s): | O WS, Tang F |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2012 |
| Project Title: | World Congress on Reproductive Biology 2011 The role of adrenomedullin in tubal ectopic pregnancy |
| Investigator(s): | O WS |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2011 |
| Completion Date: | 10/2011 |
| Project Title: | Adrenomedullin - a promising diagnostic marker for tubal ectopic pregnancy |
| Investigator(s): | O WS, Tang F, Ho JCM |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Chen H., Wang M.J., Chen G.W., Wei L.M., Shi H.J. and O W.S., Histone H3 protein levels regulated by ubiquitylation-dependent proteolysis in sperm from infertile men, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 120 Abstract 295. |
| Chen H., Wang M.J., OU J.X., Huang S.F., Chen G.W. and O W.S., Sperm prohibitin expression positively correlates with sperm mitochondrial potential and sperm motility in asthenospermic or oligoasthenospermic subjects, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 119 Abstract 294. |
| Li L., O W.S. and Tang F., Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1, Reproductive Biology and Endocrinology. 2011, 9: 111-123. |
| Li L., Tang F. and O W.S., Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size, Theriogenology. 2012, 77: 1846-1853. |
| Liao S., Kong L.H.M., Tang F. and O W.S., Possible functions of adrenomedullin from the seminal fluid in the female reproductive tract of the rat, Informa Healthcare. 2012, 58: 306-312. |
| Liao S., Li R.H.W., Ho J.C.M., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy, Journal of Clinical Endocrinology and Metabolism . Journal of Clinical Endocrinolog and Metabolism, 2012, 97: 2105-2112. |
| O W.S., Liao S., Li R.H.W., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., The role of adrenomedullin in tubal ectopic pregnancy, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 81 Abstract 124. |
| Wong P.F., O W.S. and Tang F., An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart, Endocrine. 2012, 41: 256-265. |
| Zhao W., Chen Q., Wu R., Wu H., Fung Y.S. and O W.S., Capillary electrophoresis with LIF detection for assessment of mitochondrial number based on the cardiolipin content, Electrophoresis . 2011, 32: 3025-3033. |
| Researcher : Pang PS |
| List of Research Outputs |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Researcher : Poon CH |
| List of Research Outputs |
| Ho Y.S., Poon C.H., Chan T.F. and Chang R.C.C., From small to big molecules: How do we prevent and delay the progression of age-related neurodegeneration?, Current Pharmaceutical Design. 2012, 18: 15-26. |
| Lau C.F., Ho Y.S., Poon C.H., Wuwongse S., Chu L.W. and Chang R.C.C., Testosterone attenuated pre-synaptic disrutpion in beta-amyloid-treated rat hippocampal neurons, 7th International Symposium on Healthy Aging. 2012, 67. |
| Poon C.H., Ho Y.S. and Chang R.C.C., Mixed cytokines treatment causes neurodegeneraton-like changes in neurons and glia, 7th International Symposium on Healthy Aging. 2012, 65. |
| Researcher : Sang Y |
| List of Research Outputs |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Sang Y., Su H., Wu W., So K.F. and Cheung R.T.F., Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury, Journal of Neurotrauma. 2011, 28: 2523-2534. |
| Researcher : So K.F. |
| Project Title: | Nanobiomedical manufacturing: the workforce of tomorrow |
| Investigator(s): | So KF, Ellis-Behnke RG, Tay DKC, Liang Y |
| Department: | Anatomy |
| Source(s) of Funding: | Innovation and Technology Support Programme |
| Start Date: | 09/2006 |
| Project Title: | Steroid therapy: effect of corticosteroid and antidepressant on sexual behavior |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | RAGE (receptor for advanced glycation end products), Abeta (beta-amyloid peptide) and ET-1 (endothelin-1) probing their effects in glaucoma with transgenic mice over-expressing ET-1 in endothelial or glial cells |
| Investigator(s): | So KF, Chung SK, Lo ACY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Neuroprotective effect of physical exercise on stressed animal model |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Project Title: | Role of JNK3/APP signaling pathway in modulating the apoptosis of optic axotomized retinal ganglion cells |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Use of induced pluripotent stem cells to study pathology of dominant optic atrophy: From Opa1 mutation, mitochondrial damage, to optic nerve atrophy |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2010 |
| Project Title: | Assessment of neurogenesis in an animal model of seasonal affective disorder. |
| Investigator(s): | So KF, Lau WM |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2011 |
| Completion Date: | 12/2011 |
| Project Title: | World Glaucoma Congress 2011 Neuroprotective Effect of an Anti-Aging Chinese Medicine, Wolfberry, on Glaucoma |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Hippocampal plasticity in adiponectin knock-out mice and diabetic mice |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Project Title: | XiangShan Science Conference: The 425th Session: Intelligent Biomedical Polymers: Frontiers and Applications Protection and Regeneration of the Central Nervous System |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Researcher : So KF |
| Project Title: | Nanobiomedical manufacturing: the workforce of tomorrow |
| Investigator(s): | So KF, Ellis-Behnke RG, Tay DKC, Liang Y |
| Department: | Anatomy |
| Source(s) of Funding: | Innovation and Technology Support Programme |
| Start Date: | 09/2006 |
| Project Title: | Steroid therapy: effect of corticosteroid and antidepressant on sexual behavior |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | RAGE (receptor for advanced glycation end products), Abeta (beta-amyloid peptide) and ET-1 (endothelin-1) probing their effects in glaucoma with transgenic mice over-expressing ET-1 in endothelial or glial cells |
| Investigator(s): | So KF, Chung SK, Lo ACY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Neuroprotective effect of physical exercise on stressed animal model |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Project Title: | Role of JNK3/APP signaling pathway in modulating the apoptosis of optic axotomized retinal ganglion cells |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Use of induced pluripotent stem cells to study pathology of dominant optic atrophy: From Opa1 mutation, mitochondrial damage, to optic nerve atrophy |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2010 |
| Project Title: | Assessment of neurogenesis in an animal model of seasonal affective disorder. |
| Investigator(s): | So KF, Lau WM |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2011 |
| Completion Date: | 12/2011 |
| Project Title: | World Glaucoma Congress 2011 Neuroprotective Effect of an Anti-Aging Chinese Medicine, Wolfberry, on Glaucoma |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Hippocampal plasticity in adiponectin knock-out mice and diabetic mice |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Project Title: | XiangShan Science Conference: The 425th Session: Intelligent Biomedical Polymers: Frontiers and Applications Protection and Regeneration of the Central Nervous System |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Chan T.F., Chiu K., Lok C.K.M., Ho W.L., So K.F. and Chang R.C.C., Morphometric analyses of retinal sections, Journal of Visualized Experiments. 2012, 60: pii 3377 doi: 10.3791/3377. |
| Chen E.Y.H., Lin X., Lam M.L.M., Chan K.W., Chang W.C., Joe G., Wong G.H.Y., Chiu C.P.Y., Khong P.L., Honer W.G., Su W., Chan C.L.W., So K.F. and Tse M., The impacts of yoga and aerobic exercise on neuro-cognition and brain structure in early psychosis - a preliminary analysis of the randomized controlled clinical trial., Schizophrenia Research. 2012, 136 (1): s56. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Delayed electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo, 7th International Symposium on Healthy Aging. 2012, 59. |
| Chiu K., So K.F. and Chang R.C.C., Immune modulation in glaucoma - can manipulation of microglial activation help?, In: Martina Kofronova and Tomas Kubena, The Mystery of Glaucoma. Croatia, InTech, 2011, Chapter 14: 257-268. |
| Chiu K., Chan T.F., Wu A.G.K., Leung I.Y.P., So K.F. and Chang R.C.C., Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?, Age. 2012, 34: 633-649. |
| Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Trans-Scleral Electrical Stimulation Enhances the Survival of Axotomized Retinal Ganglion Cells, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) and The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) . 2012, 134. |
| Chu P.H.W., Ng Y.F., Ting P.W.K., Lung J.C.Y., Ho W.C., So K.F., To C.H. and Chan H.H.L., Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram, British Journal of Ophahalmology. 2011, 95(11): 1597-1602. |
| Chu P.H.W., Ng Y.F., To C.H., So K.F., Brown B. and Chan H.H.L., Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients, Graefes Archive for Clinical and Experimental Ophthalmology. 2012, 250: 261-270. |
| Feng Q., Chung S.K. and So K.F., Non-vascular NG2 expressing cells in adult mouse retina, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 80. |
| Fu Q.L., Liao X.X., Li X., Chen D., Shi J., Wen W., Lee D.H.S. and So K.F., Soluble Nogo-66 receptor prevents synaptic dysfunction and rescues retinal ganglion cell loss in chronic glaucoma, Investigative Ophthalmology & Visual Sciences. 2011, 52(11): 8374-8380. |
| Fu Q.L., Liao X.X., Li X., Chen D., Shi J., Wen W., Lee D.H.S. and So K.F., Soluble Nogo66 receptor prevents synaptic dysfunction and rescues retinal ganglion cell loss in chronic glaucoma, Investigative Ophthalmology & Visual Science. 2011, 52(11): 8374-8380. |
| Ho T.H., Chan J.S.M., Wang C., Lau B.W., So K.F., Yuen L.P., Sham J.S.T. and Chan C.L.W., A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome, Ann Behav Med. 2012, Jun 27. [Epub ahead of print]. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Ho Y.S., Chiu K., Hung H.L., So K.F. and Chang R.C.C., Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?, In: Akhlaq A. Farooqui and Tahira Farooqui, Phytochemicals and Human Health. New York, Nova Science Publishers, Inc., 2011, Chapter VI: 157-186. |
| Ho Y.S., So K.F. and Chang R.C.C., Using Lycium Barbarum (Gouqizi) as an example to explain the holistic concept of anti-aging chinese medical herbs, The 10th Meeting of Consortium for Globalizaiton of Chinese Medicine, August 26-28, 2011, Shanghia, China. 2011, 104. |
| Lau W.M., Lee C.D., Li Y., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis, PLoS One. 2012, 7(4): e33374. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-fertility effect of Wolfberry polysaccharide against sexual inhibition caused by glucocorticoid, which is associated with adult neurogenesis, , The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, Ching. 2011, 106. |
| Lau W.M., Lee C.D., Fung M.Y., Chang R.C.C. and So K.F., Pro-sexual effect of polysaccharide from Wolfberry is associated with adult neurogenesis, 7th International Symposium on Healthy Aging. 2012, 60. |
| Lee C.D., Yau S.Y., Lau W.M. and So K.F., Exercise improves motor functions in relation to increased cell proliferation in layer 1 of the motor cortex, 16th Research Postgraduate symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 85. |
| Li H., Chang R.C.C. and So K.F., Effects of Lycium Barbarum on the survival o retinal ganglion cells after optic nerve injuries, 16th Research Postgraduate Symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 160. |
| Li H.Y., Chang R.C.C. and So K.F., Effects of the extract from wolfberry on the survival of retinal ganglion cells after optic nerve transection, 8th IBRO, Itay, 2011. B363. |
| Li X., Su H., Fu Q.L., Guo J., Lee D.H.S., So K.F. and Wu W., Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the notch pathway, Neurochemical Research. 2011, 36(12): 2363-2372. |
| Li Y., Luo J., Zheng G., Fu S., Wang T.T., Zeng H.P., So K.F., Chung S.K., Tong Y. and Shen J., Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway, PLoS One. 2011, 6(8): 22901. |
| Li Y.Y., Yang A.A., Zhu T.T., Liu Z., You S.W. and So K.F., Does-dependent and combined effects of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine on the survival of retinal ganglion cells in adult hamsters, Neural Regeneration Research. 2012, 7, Issue 10: 725-730. |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Mi X., Zhang X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, IOVS Papers in Press. 2012. |
| Qiu G., Spangler E.L., Wan R.Q., Miller M., Mattson M.P., So K.F., Cabo R., Zou S. and Ingram D.K., Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids, ELSEVIER. 2011, 33. |
| Sang Y., Su H., Wu W., So K.F. and Cheung R.T.F., Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury, Journal of Neurotrauma. 2011, 28: 2523-2534. |
| So K.F., Functional Significance of Adult Neurogenesis in the Mammalian Brain, IANR V & 9th GCNN Conference with 4th ISCITT Symposium. 國際神經修復學會第五屆&全球神經保護和再生學會第九屆年會拼第四屆國際脊髓損傷治療與臨床試驗交流會, 2012, 44. |
| So K.F., Functional significance of adult neurogenesis in the mammalian brain, The 8th Asia Pacific Symposium on Neural Regeneration (APSNR), Taiwan, April 13-15, 2012.. 2012, 25-27. |
| So K.F., Gouqizi (Wolfberry) and neuroprotection, ICMCM Conference "Milestones in Chinese Medicine Development", August 11-12, Hong Kong. 2011, 30. |
| So K.F., Tang S.W. and Lee T.M.C., Neuroprotection in steroid therapy: a rodent model, Hong Kong Medical Journal. 2012, 18: 1-3. |
| So K.F., Protection and Regeneration of the Central Nervous System, 425th Xiangshan Science Conference - The Frontiers of Smart Polymeric Biomaterials And Their Applications. 第425次香山科學會議 - 智能高分子生物醫用材料前沿科學和應用, 2012, 32-33. |
| So K.F. and Fu Q.L., Protection of Retinal Ganglion Cells and Attenuation of Synaptic Degeneration in Glaucoma using Nogo-66 Receptor Antagonist, 3rd International Congress of the Asia-Oceania Neurotrauma Society (AONTS). 2012, 39. |
| So K.F., Regeneration of optic nerve, The 7th Asia-Pacific Conference on Vision, July 15-18, 2011, Hong Kong. 2011, 10. |
| So K.F., Reproduction: a new venue for studying function of adult neurogensis, Journal of Shanxi Medical University. 2011, 42 Suppl.: 39. |
| So K.F. and Chang R.C.C., Using Lycium barbarum (Gouqizi) as an example to explain the holistic concept of anti-aging Chinese medical herbs., Proceeding of The 10th Metting of Consortium for Globilization of Chinese Medicine.. 2011, p104. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xu Y., Xiao Y., Diao Y. and So K.F., Postnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamster, Neural Regeneration Research. 2011, 6(28): 2165-2170. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum polysaccharides protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke, PLoS ONE. 2012, 7: e33596. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of Lycium Barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, 7th International Symposium on Healthy Aging. 2012, 60. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong 2012. |
| Yang D., Li S.Y., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Society for Neuroscience 2011. |
| Yang M.L., Li J.J., So K.F., Chen J.Y.H., Cheng W.S., Wu J., Wang Z.M., Gao F. and Young W., Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial, Spinal Cord. 2012, 50: 141-146. |
| Yau S.Y., Lau W.M. and So K.F., Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress, Cell Transplantation . 2011, 20: P99-111. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24. |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36. |
| Zhang E., Chang R.C.C. and So K.F., Promotion of neurogenesis by Gouqizi (Wolfberry) in experimental depression, The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, China. 2011, 106. |
| Researcher : Su H |
| List of Research Outputs |
| Li X., Su H., Fu Q.L., Guo J., Lee D.H.S., So K.F. and Wu W., Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the notch pathway, Neurochemical Research. 2011, 36(12): 2363-2372. |
| Sang Y., Su H., Wu W., So K.F. and Cheung R.T.F., Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury, Journal of Neurotrauma. 2011, 28: 2523-2534. |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36. |
| Researcher : Sy MH |
| Project Title: | Understanding the regulatory mechanisms that govern the PALB2-dependent DNA repair pathway |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2010 |
| Completion Date: | 05/2012 |
| List of Research Outputs |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Shao Z., Li F., Sy M.H., Yan W., Zhang Z., Gong D., Wen B., Huen M.S.Y., Gong Q., Wu J. and Shi Y., Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure., J Struct Biol. 2011, In Press. |
| Researcher : Sy SMH |
| Project Title: | Understanding the regulatory mechanisms that govern the PALB2-dependent DNA repair pathway |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2010 |
| Completion Date: | 05/2012 |
| List of Research Outputs |
| Researcher : Tang SW |
| List of Research Outputs |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Researcher : Ting JWM |
| List of Research Outputs |
| Ng A.W.H., Griffith J.F., Law K.Y., Ting J.W.M., Tipoe G.L., Ahuja A.T. and Chan K.M., Oblique axial MR imaging of the normal anterior cruciate ligament bundles, Skeletal Radiology. 2011, 40: 1587-1594. |
| Researcher : Tipoe GL |
| Project Title: | Green Tea Polyphenols Attenuates the severity of oxidative stress and inflammation in Non-Alcoholic Liver Disease (NAFLD) in Rats |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Completion Date: | 12/2011 |
| Project Title: | Thromboxane inhibitors reverse the inflammatory and fibrotic changes in rat liver despite continued ethanol administration. |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Completion Date: | 01/2013 |
| Project Title: | The 62nd Annual Meeting of The American Association for the Study of Liver Diseases Protective effects of Wolfberry (Lycium barbarum;LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2011 |
| Completion Date: | 11/2011 |
| Project Title: | The protective effects of Wolfberry (Lycium Barbarium Polysaccharide; LBP) in a clinically relevant orally fed non-alcoholic fatty liver disease (NAFLD) rat model |
| Investigator(s): | Tipoe GL, Ching YP, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Chiu H.Y., Ng K.S., Ma S.K., Chan C.H., Ng S.W., Tipoe G.L. and Chan L.K., Voices of donors: Case reports of body donation in Hong Kong, Anatomical Sciences Education. 2012. |
| Chiu H.Y., Ng K.S., Ma S.K., Chan C.H., Ng S.W. and Tipoe G.L., Voices of donors: case reports of body donation in Hong Kong, Anatomica Sciences Education. 2012, DOI 10.1002/ase.1280. |
| Griffith J., Law K.Y., Ting J., Tipoe G.L., Ahuja A., Chan K.M., Hung E. and Yung P., Oblique Axial MR Imaging of the Normal Anterior Cruciate Ligament Bundles and MRI Diagnosis of ACL Bundle Tears: Value Of Oblique Axial Imaging, International Skeletal Society. 2011. |
| Ip W.Y.J., Sweed T.A., Fung K.K.B., Tipoe G.L. and Pun T.S., A new technique of single portal endoscopic carpal tunnel release, Techniques in Hand & Upper Extremity Surgery. 2012, 16(1): 27-29. |
| Lam C.S., Tipoe G.L. and Fung M.L., Neuroprotective effects of Lycium barbarum polysaccharides against rat hippocampal apoptosis induced by chronic intermittent hypoxia, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Lam C.S., Tipoe G.L., Chang R.C.C., Cheung K.H. and Fung M.L., Protective effect of Lycium barbarum polysaccharides against rat hippocampal injury induced by chronic intermittent hypoxia, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P31, 3/2012. |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Lam S.S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia., XVIIIth ISAC (International Society for Arterial Chemoreception) Conference. 2011. |
| Lam S.Y.S., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, The 18th International Society for Arterial Chemoreception Meeting, Hamilton, Canada, P4.4, 7/2011. |
| Liong E.C., Xiao J., Lau T.Y.H., Nanji A.A. and Tipoe G.L., Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model, Food and Chemical Toxicology. 2012, 50: 861-866. |
| Liu Y., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Blockade of renin-angiotensin system attenuates local inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P19, 3/2012. |
| Liu Y., Tipoe G.L., Xiao J., Huang Y. and Fung M.L., NADPH oxidase upregulated by AT1 receptor mediates chronic intermittent hypoxia-induced oxidative stress and inflammation in rat adrenal medulla, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Ng A.W.H., Griffith J.F., Law K.Y., Ting J.W.M., Tipoe G.L., Ahuja A.T. and Chan K.M., Oblique axial MR imaging of the normal anterior cruciate ligament bundles, Skeletal Radiology. 2011, 40: 1587-1594. |
| Pan J., Tipoe G.L., Xiao J., Liu Y. and Fung M.L., Blockade of AT1 receptor mitigates hepatic oxidative stress and inflammation induced by intermittent hypoxia in rats, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2012, DOI 10.1007/s00394-012-0301-0. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Xiao J., Ching Y.P., Fung M.L. and Tipoe G.L., The protective mechanisms of Lycium Barbarum polysaccharides in non-alcoholic fatty liver disease, 16th Research Postgraduate Symposium, HKU, P2.24, 12/2011. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Researcher : Tirrell LS |
| List of Research Outputs |
| Tirrell L.S. and Chung S.K., Knockout of RhoGTPase Activating Protein DLC2 in Mice Causes Altered Pain Response and Impaired Glucose Tolerance, Anatomy Postgraduate Symposium. 2012. |
| Researcher : Tong J |
| List of Research Outputs |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Researcher : Tsang AW |
| List of Research Outputs |
| Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64. |
| Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752. |
| Tsang A.W., Wong G.T.H., Wuwongse S., Ho Y.S., Law A.C.K., Chang R.C.C. and Wuwongse S., Corticosterone-induced changes to tau protein in a model of depression, 7th International Symposium on Healthy Aging. 2012, 64. |
| Researcher : Tsang C.M. |
| Project Title: | Genetic predisposition in premalignant nasopharyngeal epithelial cells to facilitate clonal and persistent EBV infection |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Researcher : Tsang CM |
| Project Title: | Genetic predisposition in premalignant nasopharyngeal epithelial cells to facilitate clonal and persistent EBV infection |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Tsao G.S.W., Tsang C.M., Pang P.S., Zhang G., Chen H. and Lo K.W., The biology of EBV infection in human epithelial cells, Seminar in Cancer Biology. 2012, 22: 137-143. |
| Wang N., Feng Y., Lau E.P., Tsang C.M., Ching Y.P., Man K., Tong Y., Nagamatsu T., Su W. and Tsao G.S.W., F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration., Integrate Cancer Therapy. 2011. |
| Researcher : Tsao G.S.W. |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Completion Date: | 10/2011 |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | The role of STAT activation in regulating persistence of EBV infection in premalignant nasopharyngeal epithelial cell model |
| Investigator(s): | Tsao GSW, Chen H |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | The impact of Bmi-1 expression on mitosis and cancer |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2009 |
| Project Title: | Regulation of Epstein-Barr virus infection in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Completion Date: | 12/2011 |
| Project Title: | NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2010 |
| Project Title: | The role of EGFR in immortalization and malignant transformation of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | American Association for Cancer Research (AACR) annual meeting Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2012 |
| Completion Date: | 04/2012 |
| Project Title: | The role of IL6 on EBV-infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Tsao GSW |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Completion Date: | 10/2011 |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | The role of STAT activation in regulating persistence of EBV infection in premalignant nasopharyngeal epithelial cell model |
| Investigator(s): | Tsao GSW, Chen H |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | The impact of Bmi-1 expression on mitosis and cancer |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2009 |
| Project Title: | Regulation of Epstein-Barr virus infection in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Completion Date: | 12/2011 |
| Project Title: | NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2010 |
| Project Title: | The role of EGFR in immortalization and malignant transformation of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | American Association for Cancer Research (AACR) annual meeting Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2012 |
| Completion Date: | 04/2012 |
| Project Title: | The role of IL6 on EBV-infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505. |
| Chan M.C.W., Chan W.Y., Tsao G.S.W. and Peiris J.S.M., Pathogenesis of SARS coronavirus infection using human lung epithelial cells: an in vitro model., Hong Kong Med J.. 2011, 17 Suppl 6: 31-5. |
| Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129(3): 565-573. |
| Chiang A.K.S., Hui K.F., Ho D.N.Y., Tsang C.M., Middledorp J.M. and Tsao G.S.W., Activation of lytic cycle of Epstein-Barr virus by subroylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma., Int J cancer. 2012. |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Feng Y., Wang M.N., Zhu M., Chow O.Y., Ng K.M., Tong Y. and Tsao G.S.W., Comparative study on bear bile and coptis. Handbook with programme 19, 8th world congress of Chinese Medicine. 2011. |
| Hau P.M., Yip Y.L., Huen M.S.Y. and Tsao G.S.W., Loss of DNp63a promotes mitotic exit in epithelial cells, FEBS Letters. 2011. |
| Hui K.C., Lai K.Y., Chan K.W., Luk J.M., Lee N.P.Y., Chung Y., Cheung L.C., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Med Oncol.. 2012, [Epub ahead of print]. |
| Hui K.C., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Cytoplasmic Forkhead Box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage, World Journal of Surgery. 2012, 36(1): 90-97. |
| Lam C.L.K., Chan G.C.F., Lam T.H., Lee P.P.W., Leung A.Y.M., Leung G.K.K., Tang S.C.W. and Tsao G.S.W., 育醫造才: 探索醫學世界 第二冊, 香港大學李嘉城醫學院, 2012, 第äºå. |
| Law W.L., Cheung A.K.L., Kashuba V.I., Pavlova T.V., Zabarovsky E.R., Lung H.L., Cheng Y., Chua D.T.T., Kwong D.L.W., Tsao G.S.W., Sasaki T., Stanbridge E.J. and Lung M.L., Anti-angiogenic And Tumor-suppressive Roles Of Candidate Tumor Suppressor Gene, Fibulin-2, In Nasopharyngeal Carcinoma , Oncogene. 2011, 10.1038/onc.2011.272. |
| Li B., Li J., Tsao G.S.W. and Cheung A., PI3K/AKT pathway as a therapeutic target in human esophageal cancer, 21st Asia Pacific Cancer Conference 2011. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis, In: Proceedings of the American Association for Cancer Research; 2012 March 31 - April 4; Chicago, IL. Philadelphia (PA): AACR. 2012, Abstract nr 4361. |
| Li J., Li F.Y.L., Xu A., Cheng B., Tsao G.S.W., Fung M.L. and Leung W.K., Lipopolysaccharide and Hypoxia Induce HIF-1 Activation in Human Gingival Fibroblasts, Journal of Periodontology. 2011, 1-8. |
| Li L., Ying J., Li H., Zhang Y., Shu X., Fan Y., Tan J., Cao Y., Tsao G.S.W., Srivastava G., Chan A.T. and Tao Q., The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas, Oncogene. 2011, [Epub ahead of print]. |
| Lo P.H.Y., Ko J.M.Y., Yu Z., Law S.Y.K., Wang L.D., Li J.L., Srivastava G., Tsao G.S.W., Stanbridge E.J. and Lung M.L., The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma, Cancer Letters. 2012, 316(1): 39-45. |
| Lok T.M., Sy M.H., Dong S., Ching Y.P., Tsao G.S.W., Thomson T. and Huen M.S.Y., Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation., Nucleic Acids Res. 2012, 40(1): 196-205. |
| Ma S.K.Y., Bao Y., Kwan P.S., Chan Y.P., Tong M., Fu L., Zhang N., Tong A.H.Y., Qin Y.R., Tsao G.S.W., Chan K.W., Lok S. and Guan X., Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma, Gastroenterology. 2012, 143(3): 675-686. |
| Shu X.S., Geng H., Li L., Ying J., Ma C., Wang Y., Poon F.F., Wang X., Ying Y., Yeo W., Srivastava G., Tsao G.S.W., Yu J., Sung J.J., Huang S., Chan A.T. and Tao Q., The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors, PLoS One. 2011, 6(11): e27346. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Tsao G.S.W., EBV infection and nasopharyngeal carcinoma., Cell Biology Course. Pasteur Research Institute, HKU. 2012. |
| Tsao G.S.W., Establishment Of Faculty Core Facility For Imaging And Flow Cytometry In The Faculty Of Medicine, University Of Hong Kong. Invited Lecture. The Jinan University, Guangzhou. Mainland China. Special Training Course For Core Laboratory And Resources Management (暨南大学实验系列讲座: 实验技术骨干培训学习). Hosted By Jinan University, Management Department（暨南大学资产处). May 30, 2012, 2012. |
| Tsao G.S.W., PLoS One, 2011. |
| Tsao G.S.W., Stromal Inflammation And Ebv Infection In Nasopharyngeal Carcinoma. Invited Lecture Presented In Chinese Human Proteomic Organization (chupo) Meeting In Pan Yu, Guangzhou. Organized By Jinan University, Guangzhou. China. December 21 2011, 2011. |
| Tsao G.S.W., Tsang C.M., Pang P.S., Zhang G., Chen H. and Lo K.W., The biology of EBV infection in human epithelial cells, Seminar in Cancer Biology. 2012, 22: 137-143. |
| Tsao G.S.W., • The Open Gene Therapy Journal . 2011. |
| Wang N., Feng Y., Lau E.P., Tsang C.M., Ching Y.P., Man K., Tong Y., Nagamatsu T., Su W. and Tsao G.S.W., F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration., Integrate Cancer Therapy. 2011. |
| Wang N., Feng Y., Zhu M., Tsang C.M., Man K., Tong Y. and Tsao G.S.W., Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism, Journal of cellular biochemistry. 2011. |
| Wong C.L., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C.O., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International Journal of Cancer. 2012, 130(1): 83-95. |
| Zhu M., Wang M.N., Tsao G.S.W. and Feng Y., miR-21 and miR-23a were altered by Coptidis Rhizoma Aqueous Extract in Human Liver Cancer Cells, 11th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM). 2011. |
| Researcher : Tse EYT |
| List of Research Outputs |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Researcher : Tso HW |
| Project Title: | Role of pluripotent stem cells-derived cardiac fibroblasts on cardiomyocytes proliferation and function |
| Investigator(s): | Tso HW, Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 06/2012 |
| List of Research Outputs |
| Tso H.W., Yim L.Y., Lau K.L.K., Li R.A. and Chan C.W.Y., Distinct immunomodulatory effect of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells, Re-engineering Regenerative Medicine 2012. 2011. |
| Researcher : Van G |
| List of Research Outputs |
| Mi X., Chiu K., Van G., Leung J.W.C., Lo A.C.Y., Chung S.K., Chang R.C.C. and So K.F., Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma, Neural Regeneration Research. 2012, 7(9): 645-651. |
| Researcher : Wang X |
| Project Title: | The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors |
| Investigator(s): | Wang X, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Lance Armstrong Foundation - General Award |
| Start Date: | 10/2003 |
| Project Title: | Significance of MAD2 expression to chromosomal instability in prostate cancer |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Association for International Cancer Research - General Award |
| Start Date: | 04/2004 |
| Project Title: | Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 08/2005 |
| Researcher : Wang X |
| Project Title: | Angio-(1-7) and ACE2 during normal and hypertensive pregnancy |
| Investigator(s): | Wang X, Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Wong LLY |
| Project Title: | An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma |
| Investigator(s): | Wong LLY, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Lee C.W., Wong L.L.Y., Tse E.Y.T., Liu M.H.F., Leong V.Y.L., Lee M.F., Hardie D.G., Ng I.O.L. and Ching Y.P., AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Research. 2012. |
| Wong L.L.Y., Lam I.P.Y., Wong T.Y.N., Lai W.L., Zhou Y., Hung W.Y. and Ching Y.P., An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma, AACR, March, 2012. |
| Researcher : Wong R |
| List of Research Outputs |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Researcher : Wong WM |
| List of Research Outputs |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36. |
| Researcher : Wong YC |
| Project Title: | Induction of breast carcinogenesis by a combination of androgens and oestrogens |
| Investigator(s): | Wong YC, Xie B |
| Department: | Anatomy |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1997 |
| Project Title: | The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian |
| Investigator(s): | Wong YC, Wang X, Ho KMT |
| Department: | Anatomy |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Researcher : Wu AGK |
| List of Research Outputs |
| Chiu K., Chan T.F., Wu A.G.K., Leung I.Y.P., So K.F. and Chang R.C.C., Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?, Age. 2012, 34: 633-649. |
| Researcher : Wu W |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury |
| Investigator(s): | Wu W, Yick LW, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 11/2003 |
| Project Title: | Research Output Prize |
| Investigator(s): | Wu W, Su H, Wong WM, So KF, Wu EX |
| Department: | Anatomy |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 10/2008 |
| Project Title: | Effects and mechanisms of fingolimod on oligodendrocyte maturation and remyelination in animals with experimental autoimmune encephalomyelitis |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2010 |
| Completion Date: | 12/2011 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with self-assembling peptide nanofibre scaffold (SAPNS) |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | Influence of corticospinal tract on the survival and regeneration of spinal motor neurons after axonal injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyb26b1 mediates differential regulation of RA signaling in neural progenitor populations along the anterior-posterior axis of the adult spinal cord, Days of Molecular Medicine 2011, Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011. |
| Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyp26b mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells., Stem Cells and Development. 2012, Epub ahead of print. |
| Li X., Su H., Fu Q.L., Guo J., Lee D.H.S., So K.F. and Wu W., Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the notch pathway, Neurochemical Research. 2011, 36(12): 2363-2372. |
| Sang Y., Su H., Wu W., So K.F. and Cheung R.T.F., Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury, Journal of Neurotrauma. 2011, 28: 2523-2534. |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36. |
| Researcher : Xiao J |
| List of Research Outputs |
| Liong E.C., Xiao J., Lau T.Y.H., Nanji A.A. and Tipoe G.L., Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model, Food and Chemical Toxicology. 2012, 50: 861-866. |
| Liu Y., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Blockade of renin-angiotensin system attenuates local inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P19, 3/2012. |
| Liu Y., Tipoe G.L., Xiao J., Huang Y. and Fung M.L., NADPH oxidase upregulated by AT1 receptor mediates chronic intermittent hypoxia-induced oxidative stress and inflammation in rat adrenal medulla, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Pan J., Tipoe G.L., Xiao J., Liu Y. and Fung M.L., Blockade of AT1 receptor mitigates hepatic oxidative stress and inflammation induced by intermittent hypoxia in rats, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2012, DOI 10.1007/s00394-012-0301-0. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Xiao J., Ching Y.P., Fung M.L. and Tipoe G.L., The protective mechanisms of Lycium Barbarum polysaccharides in non-alcoholic fatty liver disease, 16th Research Postgraduate Symposium, HKU, P2.24, 12/2011. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Researcher : Yang D |
| List of Research Outputs |
| Li S.Y., Yang D., Fu Z., Woo T., Wong D.S.H. and Lo A.C.Y., Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke, Neurobiology of Disease. 2012, 45: 624-32. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum polysaccharides protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke, PLoS ONE. 2012, 7: e33596. |
| Yang D., Li S.Y., Yeung C.M., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong 2012. |
| Yang D., Li S.Y., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Protective effects of lycium barbarum polysaccharides on cerebral edema and blood-brain barrier disruption after ischemic stroke, Society for Neuroscience 2011. |
| Researcher : Yang J |
| Project Title: | Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions |
| Investigator(s): | Yang J, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336. |
| Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36. |
| Researcher : Yang X |
| List of Research Outputs |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Researcher : Yau SY |
| Project Title: | Significance of mTOR signalling pathway in mediating the beneficial effects of physical exercise on hippocampal plasticity in stressed rats |
| Investigator(s): | Yau SY, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 08/2012 |
| List of Research Outputs |
| Lee C.D., Yau S.Y., Lau W.M. and So K.F., Exercise improves motor functions in relation to increased cell proliferation in layer 1 of the motor cortex, 16th Research Postgraduate symposium, Hong Kong, Dec. 7 & 8, 2011.. 2011, 85. |
| Yau S.Y., Lau W.M. and So K.F., Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress, Cell Transplantation . 2011, 20: P99-111. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Mild stress –induced hippocampal cell proliferation and dendritic complexity is associated with improved spatial learning in rats., Journal of Indian Academy of Neurosciences.. 2011, 17: 21. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PLoS ONE. 2011, 6(9): e24263. |
| Yau S.Y., Lau W.M., Tong J., Wong R., Ching Y.P., Qiu G., Tang S.W., Lee T.M.C. and So K.F., Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats, PlosOne. 2011, 6: e24263. |
| Yau S.Y., Lee C.D., Lau W.M., Lee T.M.C., Ching Y.P., Tang S.W. and So K.F., Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition, Neural Regeneration Research. 2011, 6(34): 2645-2655. |
| Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24. |
| Researcher : Yeung PKK |
| Project Title: | The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice |
| Investigator(s): | Yeung PKK, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| List of Research Outputs |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Researcher : Yip HKF |
| Project Title: | In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death |
| Investigator(s): | Yip HKF, Tsao GSW, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2005 |
| Project Title: | Telomerase immortalization of retinal ganglion cells derived from the embryonic mouse retinal progenitor cells |
| Investigator(s): | Yip HKF, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Telomerase acts downstream of brain-derived neurotrophic factor signaling in neural progenitor cells isolated from the aged mouse brain |
| Investigator(s): | Yip HKF, Tsao GSW, Zhou Z |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 09/2011 |
| Project Title: | Combined treatment of lithium and noggin inhibits astroglios after spinal cord injury by deactivation of GSK-3β/STAT3 are BMP/Smad pathways in the endogenous adult neural stem cells |
| Investigator(s): | Yip HKF, Shum DKY |
| Department: | Anatomy |
| Source(s) of Funding: | Spinal Cord Injury Research Grant |
| Start Date: | 05/2010 |
| Project Title: | Directed differentiation of human embryonic stem cell-derived retinal progenitors into retinal ganglion cells by BMP4 in vitro. |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2011 |
| Completion Date: | 06/2012 |
| Project Title: | Effect of noggin on the modification of axon-growth properties of astrocytes in spinal cord injury |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Niu C. and Yip H.K.F., Neuroprotective signaling mechanisms of telomerase are regulated by brain-derived neurotrophic factor in rat spinal cord motor neurons, Journal of Neuropathology and Experimental Neurology. 2011, 70(7): 634-652. |
| Yip H.K.F. and Liu M., Id2 Expression In The Adult Mouse Subventricular Zone, US Society of Neuroscience Annual Meeting, 2011. |
| Researcher : Yip YL |
| Project Title: | Role of cyclin D1 in immortalization and differentiation of nasopharyngeal epithelial cells |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2011 |
| List of Research Outputs |
| Deng W., Pang P.S., Tsang C.M., Hau P.M., Yip Y.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Impairs G2 Checkpoint in Human Nasopharyngeal Epithelial Cells through Defective Chk1 Activation, PLoS One. 2012, 7. |
| Hau P.M., Yip Y.L., Huen M.S.Y. and Tsao G.S.W., Loss of DNp63a promotes mitotic exit in epithelial cells, FEBS Letters. 2011. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Researcher : Young W |
| List of Research Outputs |
| Yang M.L., Li J.J., So K.F., Chen J.Y.H., Cheng W.S., Wu J., Wang Z.M., Gao F. and Young W., Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial, Spinal Cord. 2012, 50: 141-146. |
| Researcher : Yu MS |
| List of Research Outputs |
| Yik S.Y., Yu M.S., Ho Y.S., Lai S.W., Cheung Y.T., So K.F. and Chang R.C.C., Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons, Hong Kong Medical Journal. 2012, 18 No. 1 Supplement: 42-44. |
| Researcher : Yu WY |
| List of Research Outputs |
| Yu W.Y., Sheridan C., Grierson I., Lo A.C.Y. and Wong D.S.H., Enhanced Survival and Expansion of Bovine Corneal Endothelial Progenitors using Accutase, ARVO 2012 Annual Meeting. 2012. |
| Yu W.Y., Sheridan C., Grierson I., Mason S., Kearns V., Lo A.C.Y. and Wong D.S.H., Journal of Biomedicine and Biotechnology, Progenitors for the corneal endothelium and trabecular meshwork: A potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma. 2011, 412743. |
| Researcher : Zhang E |
| List of Research Outputs |
| Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24. |
| Zhang E., Beneficial effects of lycium barbarum in rat depression model. 2011, 140 pages. |
| Zhang E., Chang R.C.C. and So K.F., Promotion of neurogenesis by Gouqizi (Wolfberry) in experimental depression, The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, China. 2011, 106. |
| Researcher : Zhang E |
| List of Research Outputs |
| Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24. |
| Zhang E., Beneficial effects of lycium barbarum in rat depression model. 2011, 140 pages. |
| Zhang E., Chang R.C.C. and So K.F., Promotion of neurogenesis by Gouqizi (Wolfberry) in experimental depression, The 10th Meeting of Consortium for Globalization of Chinese Medicine, August 26-28, 2011, Shanghai, China. 2011, 106. |
| Researcher : Zhang G |
| List of Research Outputs |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Tsao G.S.W., Tsang C.M., Pang P.S., Zhang G., Chen H. and Lo K.W., The biology of EBV infection in human epithelial cells, Seminar in Cancer Biology. 2012, 22: 137-143. |
| Zhang G., Epstein-Barr virus (EBV) infection and STAT3 activation in nasopharyngeal epithelial cells. 2012, 202 pages. |
| Researcher : Zhang G |
| List of Research Outputs |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Zhang G., Deng W., Lo K.W., Lau M.Y., Hau P.M. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells , AACR Annual Meeting 2012. |
| Tsao G.S.W., Tsang C.M., Pang P.S., Zhang G., Chen H. and Lo K.W., The biology of EBV infection in human epithelial cells, Seminar in Cancer Biology. 2012, 22: 137-143. |
| Zhang G., Epstein-Barr virus (EBV) infection and STAT3 activation in nasopharyngeal epithelial cells. 2012, 202 pages. |
| Researcher : Zhang Q |
| List of Research Outputs |
| Chang R.C.C., Zhang Q., Hung H.L., Ho Y.S. and Wuwongse S., Aggregation of the endoplasmic reticulum may play a major role in initiating autophagic flux in oligomeric b-amyloid peptide-treated neurons, Society for Neuroscience 2011. Program#/Poster#: 637.10. |
| Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., How do endoplasmic reticulum and mitochondria respond when neurons are in the emergency room?, The Fifth International Congress of the Asian Society Against Dementia - Action, Strategies and Developments, Hong Kong, Nov. 5-6, 2011. 35. |
| Ho Y.S., Yang X., Lau C.F., Hung H.L., Wuwongse S., Zhang Q., Wang J., Baum L., So K.F. and Chang R.C.C., Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in alzheimer's disease pathogenesis, Journal of Alzheimer's Disease. 2011, 28(4): 839-854. |
| Hung H.L., Cheung Y.T., Wuwongse S., Zhang Q., Ho Y.S. and Chang R.C.C., Mitochondrial dynamics in Alzheimer's disease: When shape matters, 7th International Symposium on Healthy Aging. 2012, 50. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Law A.C.K. and Chang R.C.C., Synaptic dysfunction in Alzheimer's disease and depression, 7th International Symposium on Healthy Aging. 2012, 67. |
| Wuwongse S., Hung H.L., Zhang Q., Ho Y.S., Chang R.C.C. and Law A., Synaptic vesicle protein pathology in Alzheimer's disease and depression, Alzheimer's and Dementia 2011. 7(4) Supp 1: S587. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of endoplasmic reticulum triggered slective autophagic degradation in primary cultures of rat hippocampal neurons stressed by oligomeric Ab, 7th International Symposium on Healthy Aging. 2012, 59. |
| Zhang Q., Hung H.L., Ho Y.S., Wuwongse S. and Chang R.C.C., Aggregation of the endoplasmic reticulum triggered by oligomeric beta-amyloid peptides could initiate autophagy, Alzheimer's and Dementia. 2011, 794) Suppl. 1: S406. |
| Zhu Q., Zhang Q., Lau C.F., Chao J., Sun Z., Chang R.C.C., Chen F. and Wang M., In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple, Food Chemistry. 2012, 135: 1762-1768. |
| Researcher : Zhang X |
| List of Research Outputs |
| Mi X., Zhang X., Feng Q., Lo A.C.Y., Chung S.K. and So K.F., Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells, Investigative Ophthalmology & Visual Science. The Association for Research in Vision and Ophthalmology, In, 2012, 53, No 8: 4842-4851. |
| Mi X., Zhang X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, IOVS Papers in Press. 2012. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Ma H., Kien F., Maniere M., Zhang Y., Lagarde N., Tse K.S., Poon L.L.M. and Nal B., Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection, J Virol. 2012, 86(3): 1789-801. |
| Zhang Y., Identification of a novel interaction between the M2 protein of influenza A virus and cyclin D3: consequences for cell cycle progression. 2011, 84 pages. |
| Researcher : Zhou Y |
| List of Research Outputs |
| Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781. |
| Wong L.L.Y., Lam I.P.Y., Wong T.Y.N., Lai W.L., Zhou Y., Hung W.Y. and Ching Y.P., An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma, AACR, March, 2012. |
| Xu Y., Ching Y.P., Zhou Y., Chiu J. and He Q.Y., Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells, Journal of Proteomics. 2011, in press. |