DEPT OF ANAESTHESIOLOGY



Researcher : Chee YE

List of Research Outputs

Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G., Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period, Expert Opin Biol Ther. 2014, 14(1): 51-61.


Researcher : Cheung CW

Project Title:The role of astrocytic ET-1 in neuropathic pain: A study using astrocytic specific ET-1 over-expressing mice (GET-1)
Investigator(s):Cheung CW, Chung SK, Irwin MG, Ng JKF, Xia Z
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2011


Project Title:Implantation of intrathecal pump for cancer pain patients
Investigator(s):Cheung CW, Tsang JWH
Department:Anaesthesiology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


Project Title:Central Administration of ETAR Antagonist BQ-123 Ameliorate Mechanical Allodynia in Rats Using a Sciatic Nerve Ligation Model
Investigator(s):Cheung CW, Ng JKF
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:03/2013


Project Title:Cash donation to support service and clinical research (Pain Management)
Investigator(s):Cheung CW, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:Cash donation for supporting service and clinical research
Start Date:11/2013


Project Title:CXCL12/CXCR4 chemokine signaling in astrocytes following noxious stimulation
Investigator(s):Cheung CW, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014


List of Research Outputs

Cheung C.W., Chairman, 2nd Joint Shenzhen and Hong Kong Scientific Symposium in Pain., Shenzhen Nanshan Hospital. 6th June 2014.. 2014.
Cheung C.W., Chairman, SAHK Symposium., Annual Scientific Meeting in Anaesthesiology in Hong Kong 2013. 16th November 2013.. 2013.
Cheung C.W. and Xia Z., Dexmedetomidine reduced astrocyte connexin 43 and attenuated neuropathic pain induced by partial sciatic nerve ligation in rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB503.
Cheung C.W., Peer Reivewer, International Journal of Oral and Maxillofacial Surgery. 2014.
Cheung C.W., Peer Reviewer, Clinical, Cosmetic and Investigational Dentistry. 2014.
Cheung C.W., Peer Reviewer, Expert Opinion on Investigational Drugs. 2014.
Cheung C.W., Peer Reviewer, Hong Kong Medical Journal. 2014.
Cheung C.W., Peer Reviewer, International Journal of Anesthesiology Research. 2014.
Cheung C.W., Peer Reviewer, International Journal of Oral and Maxillofacial Surgery. 2014.
Cheung C.W., Peer Reviewer, World Journal of Anesthesiology. 2014.
Cheung C.W., Peer Reviewer, World Journal of Clinical Cases. 2014.
Cheung C.W., Sepaker, Endothelin-1 in Pain, The 2nd Oriental Congress of Anesthesiology and Perioperative Medicine, OCAP 2013. 5th to 7th July 2013. Shanghai, China. 2013.
Cheung C.W., Speaker, Chronic pain in Hong Kong: change over the last decade., 2013 Annual Scientific Meeting of Macau Physician Society. 19th October 2013. Macau.. 2013.
Cheung C.W., Speaker, Endothelin-1 and neuropathic pain., 華西麻醉鎮痛和危急重症醫學國際學術週暨第五屆華西可視化技術在麻醉鎮痛與危重急救中的應用大會. 12-23 May 2014. Chengdu, China.. 華西麻醉鎮痛和危急重症醫學國際學術週暨第五屆華西可視化技術在麻醉鎮痛與危重急救中的應用大會, 2014.
Cheung C.W., Speaker, Endothelin-1 in Neuropathic Pain., Physiology Symposium 2014 & joint Scientific Conference of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong. 12th to 14th June 2014.. 2014.
Cheung C.W., Speaker, Endothelin-1 in neuropathic pain: central vs peripheral, Annual Scientific Meeting in Anaesthesiology in Hong Kong 2013. 16th November 2013.. 2013.
Cheung C.W., Speaker, Interventional pain management for oro-facial pain at Queen Mary Hospital, Hong Kong., 深圳南山醫院疼痛交流會議. 14th December 2013. Shenzhen, China.. 深圳南山醫院疼痛交流會議, 2013.
Cheung C.W., Speaker, Management of Limb Pain., University of Hong Kong Certificate Course: Management of Rheumatoid Arthritis and Limb Pain. 29th March 2014. Hong Kong.. 2014.
Cheung C.W., Speaker, Translational Research in Pain Medicine: Is it Easy? , The 3rd Oriental Congress of Anesthesiology and Perioperative Medicine, OCAP 2014. 20th to 22nd June 2014, Shanghai.. 2014.
Cheung C.W., Speaker. Use of antidepressants in the management of chronic pain., Cymbalta Scientific Lecture, 21st March 2014. Macau.. 2014.
Cheung C.W., QIU Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G., The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery, Anaesthesia. 2014, Epub ahead of print.
Feng L., Liu T.T., Ye D.W., QIU Q., Xiang H.B. and Cheung C.W., Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: A virally mediated transsynaptic tracing study in transgenic mouse model., Epilepsy Behav. Academic Press, 2014, 31C: 114-116.
Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35.
LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.
Mei W., Li M., Yu Y., Cheung C.W., Cao F., Nie B., Zhang Z., Wang P. and Tian Y., Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study, European Journal of Pain. Wiley, 2014, 18: 238-248.
Ye D.W., Ding D.F., Liu T.T., Tian X.B., Liu C., Li R.C., Xiang H.B. and Cheung C.W., The optimal segment for spinal cord stimulation in intractable epilepsy: a virally mediated transsynaptic tracing study in spinally transected transgenic mice, Epilepsy Behav. Academic Press, 2013, 29: 599-601.


Researcher : Choi SW

List of Research Outputs

Cheung C.W., QIU Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G., The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery, Anaesthesia. 2014, Epub ahead of print.


Researcher : Gao X

List of Research Outputs

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.


Researcher : Greenland KB

List of Research Outputs

Greenland K.B. and Irwin M.G., Airway management - 'spinning silk from cocoons'(-Chinese idiom), Anaesthesia. 2014 April. 2014, 69(4): 296-300.


Researcher : HUANG C

List of Research Outputs

Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24.
HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59.


Researcher : Hung KL

List of Research Outputs

Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35.


Researcher : Irwin MG

Project Title:A comparative study of hydroxyethyl starch (130/0.4) and gelatin on the immune response in paediatric scoliosis surgery
Investigator(s):Irwin MG, Wylie SJ
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:01/2009


Project Title:Radiofrequency therapy for chronic and cancer pain patient
Investigator(s):Irwin MG, Cheung CW
Department:Anaesthesiology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Effects of non-invasive remote ischemic preconditioning-induced cardioprotection in Type 1 diabetic rodents: Role of STAT-3 activation
Investigator(s):Irwin MG, Vanhoutte PMGR, Wang Y, Wong GTC, Xia Z
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2011


Project Title:Restoration of Volatile Anesthetic Postconditioning Cardioprotection in Diabetes---Role of Brg1 mediated Nrf2/STAT3 activation
Investigator(s):Irwin MG, Xia Z, Wang Y, Vanhoutte PMGR, Wong GTC
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013
Completion Date:04/2014


Project Title:Effects of ketamine on the CGRP-CRLR ligand-receptor complex and pain signaling
Investigator(s):Irwin MG, Cheung CW
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:05/2014


List of Research Outputs

Chen Z., Hu Z., Cai S., Gu X., Zhang H., Ruan Z., Xia Z., Irwin M.G., Feng D. and Zhang L., Differential microRNA profiling in a cellular hypoxia reoxygenation model upon posthypoxic propofol treatment reveals alterations in autophagy signalling network, Oxid Med Cell Longev. 2013, 378484.
Cheung C.W., QIU Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G., The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery, Anaesthesia. 2014, Epub ahead of print.
Greenland K.B. and Irwin M.G., Airway management - 'spinning silk from cocoons'(-Chinese idiom), Anaesthesia. 2014 April. 2014, 69(4): 296-300.
HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59.
Irwin M.G., 2nd Oriental Congress of Anaesthesiology and Perioperative Medicine, Shanghai. 2013.
Irwin M.G., Advisory Bard Member, Medical Grapevine. 2014.
Irwin M.G., Australia NZ College of Anaesthetists ASM. Singapore May. 2014.
Irwin M.G., Board Member, Children's Surgical Centre, Cambodia. 2014.
Irwin M.G., College of Anaesthetists in Ireland. Dublin May. 2014.
Irwin M.G., Editorial Board Member (senior Editor), Hong Kong Medical Journal. 2014.
Irwin M.G., Editorial Board Member, Acta Anaesthesia Taiwancia. 2014.
Irwin M.G., Editorial Board Member, Anaesthesia. 2014.
Irwin M.G., Editorial Board Member, Anaesthesia and Intensive Care Medicine. 2014.
Irwin M.G., Editorial Board Member, CPD Anaesthesia (UK). 2014.
Irwin M.G., Editorial Board Member, Clinical Window Scientific. 2014.
Irwin M.G., Editorial Board Member, Expert Opinion on Pharmacotherapy. 2014.
Irwin M.G., Editorial Board Member, F1000 Research. 2014.
Irwin M.G., Editorial Board Member, Health Services Research Committee. 2014.
Irwin M.G., Editorial Board Member, Journal of International Medical Research. 2014.
Irwin M.G., Editorial Board Member, Pain Research and Treatment. 2014.
Irwin M.G., Editorial Board Member, Perioperative Medicine. 2014.
Irwin M.G., Editorial Board Member, World Journal of Gastrointestinal Surgery. 2014.
Irwin M.G., Journal Editor, Gynecologic and Obstetric Investigation. 2014.
Irwin M.G., Journal Editor, Journal of Surgical Research. 2014.
Irwin M.G., Journal of Molecular and Cellular Cardiology, 2014.
Irwin M.G., Member, HK Hospital Authority Expert Panel in Anaesthesiology. 2014.
Irwin M.G., Oxford Textbook of Anaestheisa, Anaesthesia for ENT and Maxillofacial Surgery, Oxford University Press. 2013.
Irwin M.G., Panel member, Faculty 1000 Medicine (cardiovascular drugs in anaesthesia. 2014.
Irwin M.G., Peer Reviewer, Anaesthesia. 2014.
Irwin M.G., Peer Reviewer, Anaesthesia and Intensive Care. 2014.
Irwin M.G., Peer Reviewer, Anaesthesiology. 2014.
Irwin M.G., Peer Reviewer, Anesthesia and Analgesia. 2014.
Irwin M.G., Peer Reviewer, Asean Journal of Anaesthesiology. 2014.
Irwin M.G., Peer Reviewer, Asian Journal of Maxillofacial Surgery. 2014.
Irwin M.G., Peer Reviewer, British Journal of Anaesthesia. 2014.
Irwin M.G., Peer Reviewer, Canadian Journal of Anaesthesia. 2014.
Irwin M.G., Peer Reviewer, Canadian Journal of Physiology & Pharmacology. 2014.
Irwin M.G., Peer Reviewer, Expert Opinion on Pharmacotherapy. 2014.
Irwin M.G., Peer Reviewer, Hong Kong Medical Journal. 2014.
Irwin M.G., Peer Reviewer, Journal of Clinical Anaesthesia. 2014.
Irwin M.G., Peer Reviewer, Journal of Paediatrics, Obstetrics and Gynaecology. 2014.
Irwin M.G., Peer Reviewer, Journal of Pharmaceutical and Biochemical Analysis. 2014.
Irwin M.G., Peer Reviewer, Medical Science Monitor. 2014.
Irwin M.G., Peer Reviewer, Surgical Practice. 2014.
Irwin M.G., Referee Register, Hong Kong Research Grants Council. 2014.
Irwin M.G., Referee, Health Services Research Committee/Health Care & Promotion Fund Committee. 2014.
Irwin M.G., Textbook of Cardiothoracic Anaesthesia, Myocardial protection during cardiac surgery, Oxford University Press. 2013.
LI H., Irwin M.G. and Xia Z., Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement 663.7.
LI H., Irwin M.G. and Xia Z., Graduate Student Best Abstract Award: "Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3", The FASEB Journal/American Society of Pharmacology and Experimental Therapeutics (ASPET). 2014, 28: Supplement 663.7.
LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS, Anesth Analg: International Anesthesia Research Society (IARS) annual meeting 2014. 118: S-1 – S-319.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., Resident Abstract Award Finalist: "Propofol Confers Cardioprotection via HO-1 Dependent STAT3 Activation in Normal Rats but via Adiponectin Dependent STAT3 Activation in Type 1 Diabetic Rats", International Anesthesia Research Society (IARS) (ANESTH ANALG ). 2014, 118: S-1 – S-319.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.
Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
Li B.L., Yuen V.M.Y., Song X.R., Ye J., Ni J., Huang J.X. and Irwin M.G., Intranasal dexmedetomidine following failed chloral hydrate sedation in children, Anaesthesia. 2014, 69(3): 240-244.
Liu Y., Yang L., Tao K., Vizcaychipi M...P..., Lloyd D...M..., Sun X., Irwin M.G., Ma D. and Yu W., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release, BMC Gastroenterol. 2014, 14(1): 12.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.
Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.
Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G., Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period, Expert Opin Biol Ther. 2014, 14(1): 51-61.
WANG C., LI H., Xia Z. and Irwin M.G., Repeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB559.
Wang T., Yao S., Xia Z. and Irwin M.G., Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning, Frontiers of Medicine. 2013.
Wang Y., Zhu Q., Luo C., Zhang A., Hei Z., Su G., Xia Z. and Irwin M.G., Dual Effects of Bilirubin on the Proliferation of Rat Renal NRK52E Cells and ITS Association with Gap Junctions, Dose-Response. 2013, 11(2): 220-37.
Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G., Time to adequate oxygenation following ventilationusing the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits, Paediatr Anaesth. 2014, 24(2): 208-213.


Researcher : Jenkins CR

List of Research Outputs

Cheung T.T., Poon R.T.P., Jenkins C.R., Chu S.K.F., Chok K.S.H., Chan A.C.Y., Tsang S.H.Y., Dai W.C., Yau T.C.C., Chan S.C., Fan S.T. and Lo C.M., Survival analysis of high-intensity focused ultrasound therapy vs. transarterial chemoembolization for unresectable hepatocellular carcinomas, Liver International. 2014, Epub on 2014-01-22.


Researcher : LI H

List of Research Outputs

LI H., Irwin M.G. and Xia Z., Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement 663.7.
LI H., Irwin M.G. and Xia Z., Graduate Student Best Abstract Award: "Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3", The FASEB Journal/American Society of Pharmacology and Experimental Therapeutics (ASPET). 2014, 28: Supplement 663.7.
LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS, Anesth Analg: International Anesthesia Research Society (IARS) annual meeting 2014. 118: S-1 – S-319.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., Resident Abstract Award Finalist: "Propofol Confers Cardioprotection via HO-1 Dependent STAT3 Activation in Normal Rats but via Adiponectin Dependent STAT3 Activation in Type 1 Diabetic Rats", International Anesthesia Research Society (IARS) (ANESTH ANALG ). 2014, 118: S-1 – S-319.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.
Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
WANG C., LI H., Xia Z. and Irwin M.G., Repeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB559.
Xu J., LI H. and Xia Z., PROPOFOL AMELIORATES HYPERGLYCEMIA-INDUCED CARDIAC HYPERTROPHY AND DYSFUNCTION VIA HEME OXYGENASE-1 /STAT3 SIGNALING PATHWAY IN RATS, Anesth Analg: IARS 2014 annunal meeting. 2014, 118: S-1 – S-319.


Researcher : LIU Y

List of Research Outputs

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.


Researcher : LIU Z

List of Research Outputs

LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.


Researcher : LUO X

List of Research Outputs

Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.


Researcher : Lei S

List of Research Outputs

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
Lei S., Su W., Liu H., Xia Z...Y..., Yang Q...J..., Qiao X., Du Y., Zhang L. and Xia Z., Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-a: the role of PKC-b2 and NADPH oxidase, Oxid Med Cell Longev. 2013, 678484.


Researcher : Leung LP

List of Research Outputs

Chan E.W., Leung L.P., Tsui M.S.H., Ho H.K., Wong C.K., Kong D.C.M., Taylor D.M.C.D., Knott J.C. and Wong I.C.K., Management of acute agitation in the Accident and Emergency setting: A survey of practice in Hong Kong. , 15th International Conference on Emergency Medicine (ICEM 2014), 10-14 June 2014, Wan Chai Conference and Convention Centre. 2014.


Researcher : Liu H

List of Research Outputs

Lei S., Su W., Liu H., Xia Z...Y..., Yang Q...J..., Qiao X., Du Y., Zhang L. and Xia Z., Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-a: the role of PKC-b2 and NADPH oxidase, Oxid Med Cell Longev. 2013, 678484.


Researcher : MAO X

List of Research Outputs

LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS, Anesth Analg: International Anesthesia Research Society (IARS) annual meeting 2014. 118: S-1 – S-319.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., Resident Abstract Award Finalist: "Propofol Confers Cardioprotection via HO-1 Dependent STAT3 Activation in Normal Rats but via Adiponectin Dependent STAT3 Activation in Type 1 Diabetic Rats", International Anesthesia Research Society (IARS) (ANESTH ANALG ). 2014, 118: S-1 – S-319.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.
Zhang A., Chi X., Luo G., Hei Z., Xia H., Luo C., Wang Y., MAO X. and Xia Z., Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation, PLoS ONE. 2013, 8(10): e75262.


Researcher : Mei B

List of Research Outputs

Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.


Researcher : Ng JKF

Project Title:The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):Ng JKF, Leung SWS
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.


Researcher : QIU Q

List of Research Outputs

Cheung C.W., QIU Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G., The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery, Anaesthesia. 2014, Epub ahead of print.
Feng L., Liu T.T., Ye D.W., QIU Q., Xiang H.B. and Cheung C.W., Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: A virally mediated transsynaptic tracing study in transgenic mouse model., Epilepsy Behav. Academic Press, 2014, 31C: 114-116.
Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.


Researcher : Rodrigo MRC

Project Title:4th South Asian Confederation of Anaesthesiologists Congress Anaesthesia for Orthognathic Surgery
Investigator(s):Rodrigo MRC
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/1999


Project Title:The Association of Dental Anaesthetists 25th Anniversary Summer Scientific Meeting Patient Controlled Sedation with Propolfol
Investigator(s):Rodrigo MRC
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2002




Researcher : Sun LT

List of Research Outputs

Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.
Sun L.T., Potential Analgesic Mechanisms of Propofol , 1st Joint Shenzhen and Hong Kong Scientific Symposium in Pain. 2013.


Researcher : TAI WL

List of Research Outputs

Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.


Researcher : Tai WL

List of Research Outputs

Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014.
Hung K.L., Tai W.L., QIU Q., LUO X., LUO X., Chung S...K... and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol Cell Nurosci. 2014, May 60: 26--335.
Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.


Researcher : Tran HDD

List of Research Outputs

Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G., Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period, Expert Opin Biol Ther. 2014, 14(1): 51-61.


Researcher : Tsui MSH

List of Research Outputs

Chan E.W., Leung L.P., Tsui M.S.H., Ho H.K., Wong C.K., Kong D.C.M., Taylor D.M.C.D., Knott J.C. and Wong I.C.K., Management of acute agitation in the Accident and Emergency setting: A survey of practice in Hong Kong. , 15th International Conference on Emergency Medicine (ICEM 2014), 10-14 June 2014, Wan Chai Conference and Convention Centre. 2014.
Leung P.S.C., Man K.C.K., Chui S.L.C., Chan E.W. and Tsui M.S.H., A retrospective study of medical staff manpower and service demand in a Hong Kong Accident and Emergency Department. , 15th International Conference on Emergency Medicine (ICEM 2014), 10-14 June 2014, Wan Chai Conference and Convention Centre. 2014.


Researcher : WANG C

List of Research Outputs

WANG C., LI H., Xia Z. and Irwin M.G., Repeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB559.


Researcher : WANG Y

List of Research Outputs

Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.


Researcher : Wang T

List of Research Outputs

MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.
Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.
Wang T., Yao S., Xia Z. and Irwin M.G., Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning, Frontiers of Medicine. 2013.


Researcher : Wong CFP

List of Research Outputs

Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G., Time to adequate oxygenation following ventilationusing the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits, Paediatr Anaesth. 2014, 24(2): 208-213.


Researcher : Wong GTC

Project Title:The cardiac preconditioning effect of surgery patients
Investigator(s):Wong GTC, Irwin MG, Hiong YT, Das SR
Department:Anaesthesiology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:10/2007


Project Title:A comparative study of the effects of different anaesthetic agents on neurofibrillary tangles formation
Investigator(s):Wong GTC, Chang RCC
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:06/2014


Project Title:Evaluation of the association between the stress and inflammatory response with cognitive function after surgery in aged mice
Investigator(s):Wong GTC, Chang RCC
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2014


List of Research Outputs

Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24.
HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59.
LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS, Anesth Analg: International Anesthesia Research Society (IARS) annual meeting 2014. 118: S-1 – S-319.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., Resident Abstract Award Finalist: "Propofol Confers Cardioprotection via HO-1 Dependent STAT3 Activation in Normal Rats but via Adiponectin Dependent STAT3 Activation in Type 1 Diabetic Rats", International Anesthesia Research Society (IARS) (ANESTH ANALG ). 2014, 118: S-1 – S-319.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.
Lu Y., Wong G.T.C., Zhang Y., Hu J. and Dong C., Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine, Kaohsiung J Med Sci. 2014, 30(2): 68-72.
Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.
Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G., Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period, Expert Opin Biol Ther. 2014, 14(1): 51-61.
Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G., Time to adequate oxygenation following ventilationusing the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits, Paediatr Anaesth. 2014, 24(2): 208-213.
Wong G.T.C., Cognitive Dysfuntion in the Elderly Post Anaesthesia: Prevalence, Financial & Social Impact, 1st Asia Anaesthesia Forum Scientific Meeting, West China Hospital, Chengdu, China. 2013.
Wong G.T.C., Depth of Anesthesia: Patient State Index, 10th Meeting of Asian Society of Cardiothoracic Anesthesiologists. 2013.
Wong G.T.C., Internal Examiner for PhD Thesis titled "Generation of vasculogenic progenitor cells from human induced pluripotent stem cells for the treatment of cardiovascular diseases", 2013.
Wong G.T.C., Know your depth - follow your brain and not your heart, 17th National Conference of Indian Association of Cardiovascular and Thoracic Anaesthesiologists . 2014.
Wong G.T.C., Non-invasive Monitoring of Hemoglobin concentration, 10th Meeting of Asian Society of Cardiothoracic Anesthesiologists. 2013.
Wong G.T.C., Reviewer for Journal of Neuroscience manuscript no jnr-2014-Mar-5769, 2014.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-13-00500, International Journal of Oral & Maxillofacial Surgery, 2013.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-13-00513, International Journal of Oral & Maxillofacial Surgery, 2013.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-13-00611, International Journal of Oral & Maxillofacial Surgery, 2013.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-13-01062 International Journal of Oral & Maxillofacial Surgery, 2013.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-14-00095, International Journal of Oral & Maxillofacial Surgery, 2014.
Wong G.T.C., Reviewer for Manuscript IJOMS-D-14-00127 International Journal of Oral & Maxillofacial Surgery, 2014.
Wong G.T.C., Reviewer for Manuscript JCA-13-440 Journal of Clinical Anesthesia , 2013.
Wong G.T.C., Reviewer for manuscript number 18640, Anaesthesia, 2014.
Wong G.T.C., Reviewer for manuscript number BJA-2013-00690-TA072, British Journal of Anaesthesia, 2013.


Researcher : Wong K

List of Research Outputs

Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35.


Researcher : Xia Z

Project Title:Nitrate tolerance compromises propofol protection of the endothelium against inflammation: The role of PKC-beta2 and NADPH oxidase interaction
Investigator(s):Xia Z
Department:Anaesthesiology
Source(s) of Funding:SCA Research Starter and MidCareer Grants
Start Date:07/2008


Project Title:The role of iNOS in ischemic postconditioning cardioprotection in normal and diabetic rodents
Investigator(s):Xia Z, Irwin MG, Vanhoutte PMGR, Wang Y, Wong GTC
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2010
Completion Date:08/2013


Project Title:Effects of Adiponectin on Diabetic Heart Sensitivity to Ischemic Postconditioning: Role of STAT-3 activation
Investigator(s):Xia Z, Irwin MG, Ng JKF, Vanhoutte PMGR, Wang Y, Xu A
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Impact of CD36 over-expression on the sensitivity of the diabetic heart to Ischemic Postconditioning
Investigator(s):Xia Z, Irwin MG, Wang Y, Vanhoutte PMGR, Ng JKF, Xu A
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012
Completion Date:10/2013


Project Title:Increased FoxO1 Activation Renders the Diabetic Heart Susceptibility to ischemia/Reperfusion Injury
Investigator(s):Xia Z, Irwin MG, Wang Y, Vanhoutte PMGR, Xu A
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013
Completion Date:04/2014


Project Title:IARS 2014 Annual Meeting; PROPOFOL AMELIORATES HYPERGLYCEMIA-INDUCED CARDIAC HYPERTROPHY AND DYSFUNCTION VIA HEME OXYGENASE-1/STAT3 SIGNALING PATHWAY IN RATS/PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS
Investigator(s):Xia Z
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2014


Project Title:PKC-β2 through downregulating Caveolin-3 increases diabetic heart vulnerability to ischemia-reperfusion injury
Investigator(s):Xia Z, Irwin MG, Vanhoutte PMGR
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


List of Research Outputs

Chen Z., Hu Z., Cai S., Gu X., Zhang H., Ruan Z., Xia Z., Irwin M.G., Feng D. and Zhang L., Differential microRNA profiling in a cellular hypoxia reoxygenation model upon posthypoxic propofol treatment reveals alterations in autophagy signalling network, Oxid Med Cell Longev. 2013, 378484.
Cheung C.W. and Xia Z., Dexmedetomidine reduced astrocyte connexin 43 and attenuated neuropathic pain induced by partial sciatic nerve ligation in rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB503.
LI H., Irwin M.G. and Xia Z., Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement 663.7.
LI H., Irwin M.G. and Xia Z., Graduate Student Best Abstract Award: "Essential role of adiponectin in ischemic postconditioning cardioprotection and its association with signal transducer and activator of transcription 3", The FASEB Journal/American Society of Pharmacology and Experimental Therapeutics (ASPET). 2014, 28: Supplement 663.7.
LI H., LIU Z., Xu A., Cheung C.W., Wong G.T.C., Irwin M.G. and Xia Z., Ischemia postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adeponectin expression in mice, J Diabetes Metab. 2013, 4(6):: 109.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., PROPOFOL CONFERS CARDIOPROTECTION VIA HO-1 DEPENDENT STAT3 ACTIVATION IN NORMAL RATS BUT VIA ADIPONECTIN DEPENDENT STAT3 ACTIVATION IN TYPE 1 DIABETIC RATS, Anesth Analg: International Anesthesia Research Society (IARS) annual meeting 2014. 118: S-1 – S-319.
LI H., MAO X., Irwin M.G., Wong G.T.C., Clananchan A.S., Vanhoutte P.M.G.R. and Xia Z., Resident Abstract Award Finalist: "Propofol Confers Cardioprotection via HO-1 Dependent STAT3 Activation in Normal Rats but via Adiponectin Dependent STAT3 Activation in Type 1 Diabetic Rats", International Anesthesia Research Society (IARS) (ANESTH ANALG ). 2014, 118: S-1 – S-319.
LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.
LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, Nucleic Acids Res. 2013, 41(W1): W150-W158.
LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., The best poster presentation award, The 5th International Conference on Computational and Systems Biology, SUSTC, Shenzhen, Nov15, 2013 . 2013.
LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.
LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618.
LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014.
LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014.
Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
Lei S., Su W., Liu H., Xia Z...Y..., Yang Q...J..., Qiao X., Du Y., Zhang L. and Xia Z., Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-a: the role of PKC-b2 and NADPH oxidase, Oxid Med Cell Longev. 2013, 678484.
MAO X., Wang T., LIU Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats, PLoS ONE. 2013, 8(7):e68949.: e68949.
Mei B., Wang T., WANG Y., Xia Z., Irwin M.G. and Wong G.T.C., High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats, European Journal of Pharmacology. 2013, 718(1-3): 484-92.
QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.
Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.
WANG C., LI H., Xia Z. and Irwin M.G., Repeated Non-invasive Remote ischemic Preconditioning Confers Cardioprotection in Diabetic Rats, The FASEB Journal: Experimental Biology 2014. 28(1): LB559.
Wang T., Yao S., Xia Z. and Irwin M.G., Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning, Frontiers of Medicine. 2013.
Wang Y., Zhu Q., Luo C., Zhang A., Hei Z., Su G., Xia Z. and Irwin M.G., Dual Effects of Bilirubin on the Proliferation of Rat Renal NRK52E Cells and ITS Association with Gap Junctions, Dose-Response. 2013, 11(2): 220-37.
Xia Z., Dexmedetomidine suppresses gap junctional intercellular communication and attenuates the sensitivity of gliocytoma to temozolomid, The FASEB Journal: Experimental Biology 2014. 28(1): LB642.
Xia Z., Diabetic Heart Responsiveness to Postconditioning Cardioprotection: Mechanism and Therapies, 5th World Congress on Diabetes & Metabolism, Nov. 3-5, 2014, Las Vegas, USA. 2014.
Xia Z., Editorial board member, ISRN Anesthesiology. 2014.
Xia Z., Executive Editor, Journal of Diabetes & Metabolism. 2014.
Xia Z., External reviewer for grant agency, Reviewed 19 NSFC grants during April to May 2014. 2014.
Xia Z., Ischemia postconditioning attenuates myocardial ischemia reperfusion injury by upregulating cardiac adiponectin in mice, J Diabetes Metab. 2013, 4(6):: 23.
Xia Z., Ischemic postconditioning attenuates myocardial ischemia-reperfusion injury by up-regulating cardiac adiponectin expression in mice (Co-Chair and keynote Speaker), OMICS Group, 4th World Congress on Diabetes & Metabolism, August 14-16, 2013, Chicago-Northshore, USA. 2013.
Xia Z., N-Acetycysterine and Allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1a/HO-1 signaling in diabetic rats (Co-chair and invited speaker), OMICS Group, 4th World Congress on Diabetes & Metabolism, August 14-16, 2013, Chicago-Northshore, USA. 2013.
Xia Z., N-Acetylcysterine and allopurinol confer synergy in attanuating myocardial ischemia injury via restoring HIF-1a/HO-1 signaling in diabetic rats, J Diabetes Metab. 2013, 4(6): 90.
Xia Z., Oxidative Medicine and Cellular Longevity, Lead Guest Editor , 2014.
Xia Z., Chen Y., Fan Q. and Xue M., Oxidative stress-mediated reperfusion injury: mechanism and therapies, Oxid Med Cell Longev. 2014, 2014: 373081.
Xia Z., Peer Reviewer,, Reviewed 1 research article for "Cardiovascular Diabetiology". 2014.
Xia Z., Peer Reviewer,, Reviewed 2 research articles for "J Surgical Research". . 2014.
Xia Z., Peer Reviewer,, Reviewed one research article for "Journal of Cellular and Molecular Medicine", in Jan 2014. 2014.
Xia Z., Peer Reviewer, Reviewed 1 research article for "Anesthesiology". 2014.
Xia Z., Peer Reviewer, Reviewed 2 research articles for "Can J Anesth", between Jan 2014 to June 2014. 2014.
Xia Z., Peer reviewer and Editor, , Reviewed and edited 21 research articles for "Oxidative Medicine & Cellular Longevity", between Sept 2013 to Feb 2014. 2014.
Xia Z., Peer reviewer for Journal of Cellular and Molecular Medicine (1 paper reviewed), Journal of Cellular and Molecular Medicine. 2013.
Xia Z., Peer reviewer for Oxidative Medicine and Cellular Longevity (1 paper reviewed), Oxidative Medicine and Cellular Longevity . 2013.
Xia Z., Peer reviewer for journal Biochemical Pharmacology (1 paper reviewed), Biochemical Pharmacology. 2013.
Xia Z., Peer reviewer for journal Diabetes (1 paper reviewed), Diabetes. 2013.
Xia Z., Peer reviewer,, Reviewed 2 research articles for "British Journal of Pharmacology" between Sept 2013 to Aug 2014. 2013.
Xia Z., Peer reviewer,, Reviewed one article for "Archives of Biochemistry and Biophysics", in April 2014. 2014.
Xia Z., Peer reviewer,, reviewed 2 research articles for "Journal of Zhejiang University-SCIENCE B". 2014.
Xia Z., Propofol Cardioprotective Effects in Patients with pre-existing myocardial ischemia for Cardiac and non-Cardiac Surgeries (Keynote Speaker), Yi-Chang District of Hubei Province Anesthesia Society 2013 Annunal Meeting (July 5-7, 2013). 2013.
Xia Z., Protection of myocardial ischemia-reperfusion injury during cardiac surgery and post-operative care: design of clinical study, Joint Guangdong Provincial Anesthesia Society Annunal Meeting and the 6th South China and the 3rd Hong-Kong-Taiwan-Mainland Anesthesia meeting . 2013.
Xia Z., Speech Title: Protection of diabetic heart against ischemia reperfusion injury: current therapies. June 27, 2014, Wuhan Anesthesiologists Society Annual Meeting. 2014.
Xia Z., Speech title: Inflammation in Diabetic Neuropathic Pain, 2nd Shenzhen NanShan Hospital and HKU joint conference of pain research. 2014.
Xia Z., Synergy of Volatile and Intravenous Anesthetics in cardioprotection in patients: Issues for clinical research design and SCI paper writing (Invited Lecture), GuangZhou Medical University Anesthesia Annual Meeting (Invited speaker). 2013.
Xu J., LI H. and Xia Z., PROPOFOL AMELIORATES HYPERGLYCEMIA-INDUCED CARDIAC HYPERTROPHY AND DYSFUNCTION VIA HEME OXYGENASE-1 /STAT3 SIGNALING PATHWAY IN RATS, Anesth Analg: IARS 2014 annunal meeting. 2014, 118: S-1 – S-319.
Yao W., Luo G., Zhu G., Chi X., Zhang A., Xia Z. and Hei Z., Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model, Oxid Med Cell Longev. 2014, 2014: 258567.
Zhang A., Chi X., Luo G., Hei Z., Xia H., Luo C., Wang Y., MAO X. and Xia Z., Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation, PLoS ONE. 2013, 8(10): e75262.


Researcher : Xu J

List of Research Outputs

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.
Xu J., LI H. and Xia Z., PROPOFOL AMELIORATES HYPERGLYCEMIA-INDUCED CARDIAC HYPERTROPHY AND DYSFUNCTION VIA HEME OXYGENASE-1 /STAT3 SIGNALING PATHWAY IN RATS, Anesth Analg: IARS 2014 annunal meeting. 2014, 118: S-1 – S-319.


Researcher : Yao W

List of Research Outputs

Yao W., Luo G., Zhu G., Chi X., Zhang A., Xia Z. and Hei Z., Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model, Oxid Med Cell Longev. 2014, 2014: 258567.


Researcher : Yuen VMY

Project Title:Comparison of oral chloral hydrate and intranasal dexmedetomidine for sedation in children undergoing computerised tomography in Queen Mary Hospital
Investigator(s):Yuen VMY, Hui TWC, Wong ICK, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2014


List of Research Outputs

Li B.L., Yuen V.M.Y., Song X.R., Ye J., Ni J., Huang J.X. and Irwin M.G., Intranasal dexmedetomidine following failed chloral hydrate sedation in children, Anaesthesia. 2014, 69(3): 240-244.
Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G., Time to adequate oxygenation following ventilationusing the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits, Paediatr Anaesth. 2014, 24(2): 208-213.


Researcher : Zhang Y

List of Research Outputs

Lu Y., Wong G.T.C., Zhang Y., Hu J. and Dong C., Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine, Kaohsiung J Med Sci. 2014, 30(2): 68-72.


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