Dept of Biochemistry

DEPT OF BIOCHEMISTRY

Researcher : AO KL

List of Research Outputs

AO K.L., Wong S., SHUM K.T., Watt R.M. and Tanner J.A., Dissecting the mechanism of how Mycobacterium tuberculosis polyphosphate kinase 2 binds to polyphosphate, EMBO 2013, Amsterdam, The Netherlands . 2013.

Tanner J.A., LUI L.H.E., AO K.L., SHUM K.T. and Li L., Inorganic polyphosphate triggers interleukin 11 production in osteoblasts, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW01.S1-53.

Researcher : Au SWN

List of Research Outputs

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Au YK

List of Research Outputs

Au Y.K., Insights into the molecular pathogenesis of Campomelic Dysplasia caused by mutations in Sox9, The Croucher Foundation Advanced Study Institute: Integrative Approaches to Understanding Disorders of the Skeleton, Faculty of Medicine Building, The University of Hong Kong Dec 16-20, 2013.

Chan W.C.W., Au Y.K., Tam V., Cheah K.S.E. and Chan D., Coming together is a beginning: The making of an intervertebral disc, Birth Defects Research Part C: Embryo Today: Reviews. 2014, 102: 83-100.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse., The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan May 27-30, 2014.. 2014.

Lim F.L., Tam W.K., Au Y.K., Chan D., Cheah K.S.E., Tuan R.S., Cheung K.M.C. and Leung V.Y.L., Cadherin 2 is required for intervertebral disc homeostasis and maintenance of vacuolated phenotype in nucleus pulposus cells, World Forum for Spine Research, Xian, China, May15-17 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H. and Cheah K.S.E., The roles of Sox9 and its regulatory elements in Campomelic Dysplasia. , Embryology: Concepts & Techniques in Modern Developmental Biology, Marine Biological Laboratory, Woods Hole, Massachusetts, US, June 7 – 21, 2014. . 2014.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. . 2013, 0054(page 132).

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong.. 2013.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Researcher : BAO S

List of Research Outputs

BAO S., Deciphering the mechanisms of genetic disorders by high throughput genomic data, PhD Thesis, The University of Hong Kong. 2013.

Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes affecting host resistance to influenza by network approaches, BMC Genomics . 2013, 14(1): 816.

Bao S., Zhou X., Zhang L., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches.BMC genomics, BMC genomics. 2013.

Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.W., Wang B.B., Wang L., Zhang X.G. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches, BMC Genomics. 2013, 4: 1816 (16 pages).

Researcher : Bao S

List of Research Outputs

BAO S., Deciphering the mechanisms of genetic disorders by high throughput genomic data, PhD Thesis, The University of Hong Kong. 2013.

Researcher : Bevan SJ

List of Research Outputs

Tanner J.A., Bevan S.J., Cheng L.Y.L., Chan W.L. and Wong B.C.W., Promoting deep learning in biochemistry by diversifying assessment strategies – experience at the University of Hong Kong, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SA04-8, 626.

Researcher : Boyde TRC

List of Research Outputs

Boyde T.R.C., The kinetics of invertin action (Translated by T.R.C. Boyde), FEBS Letters. 2013.

Researcher : CHAM WC

List of Research Outputs

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Neuronal expression of heparanase 1 and heparanase 2, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 71. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 71, Neuronal expression of heparanase 1 and heparanase 2. 2014.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, Abstracts of 9th FENS Forum of Neuroscience 1603. 2014.

Ma C.W., Han L., CHAM W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic plasticity, Proc. 37^th Int’l Congress of International Union of Physiological Sciences PCB118. 2013.

Researcher : CHENG Y

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

Researcher : CHEUNG YW

List of Research Outputs

ALBANO D.R.B., CHEUNG Y.W., Tanner J.A. and Fung Y.S., Study of aptamer selection methodologies for developing piezoelectric quartz crystal biosensors to detect microalbuminaria, malaria and SARS biomarkers, 29th Philippine Chemistry Congress, Mandaluyong City, Philippines . 2014.

CHEUNG Y.W., KWOK H.C.J., LAW W.L., Watt R.M., Kotaka M. and Tanner J.A., Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase, Proceedings of the National Academy of Sciences USA. 2013, 110(40): 15967-15972.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium. 2014.

DIRKZWAGER R.M., Cheung Y.W. and Tanner J.A., Best Poster Prize - A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Best Poster Prize - Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

Tanner J.A., Cheung Y.W., Watt R.M. and Kotaka M., Loops, hairpins and flipped bases: a DNA aptamer that discriminates Plasmodium lactate dehydrogenase from the blind watchmaker, 9th Annual Meeting of the Oligonucleotide Therapeutics Society, Naples, Italy. 2013.

Tanner J.A., CHEUNG Y.W., DIRKZWAGER R.M., KINGHORN A.B. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis – discovery, characterization, structure and application, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SW01.W5-30, 87.

Tanner J.A., Cheung Y.W., KWOK H.C.J., LAW W.L., ALBANO D.R.B., Fung Y.S., Watt R.M. and Kotaka M., Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer, Aptamers in Medicine and Perspectives, Naples, Italy . 2013.

Researcher : CHONG TYI

List of Research Outputs

CHONG T.Y.I., Inducing the Progressive Differentiation of hESCs into Pancreatic Progenitor cells, MPhil Thesis, The University of Hong Kong. 2013.

Researcher : CHU TL

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates the Lineage Progression of Hypertrophic Chondrocytes, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Cham WC

List of Research Outputs

Researcher : Chan CCY

Project Title:	Role of Sedlin in the control of endocytosis
Investigator(s):	Chan CCY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	Molecular Membrane Biology; Dosage-dependent requirement of Sedlin component of the TRAPP complex in mouse embryonic development
Investigator(s):	Chan CCY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013
Completion Date:	07/2013

List of Research Outputs

Chan C.C.Y., Chan D., Tanner J.A., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of sedlin component of the TRAPP complex in mouse embryonic development, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Researcher : Chan CH

List of Research Outputs

WU L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Role of Heparanase in Controlling Airway Syndecan-1 Shedding and Airway Inflammation , 2013.

WU L.K., Chan C.H., Mak J.C.W., Tan C., Lam C.L.D., Ip M.S.M. and Shum D.K.Y., Using Polyanionic Heparin Mimetics for the treatment of COPD, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Chan CP

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47.

Chan C.P., Jin D. and Kok K.H., Influenza A virus NS1 protein suppresses innate antiviral immune response by preventing PACT-induced activation of RIG-I , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Chan C.P., Kok K.H., Tang V.H.M., Wong C.M. and Jin D., Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013, 1833: 2165-2175.

Chan C.P., The 14th Society of Chinese Bioscientists in America International Symposium Trainee Travel Award, Society of Chinese Bioscientists in America. 2013.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KEW C., LUI P.Y., Chan C.P., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes simplex virus type 1 Us11 protein inhibits type I interferon production by suppressing PACT mediated activation of RIG-I , The 5th EMBO Meeting 2013, Amsterdam, The Netherlands, September 21-24, 2013.

KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W., Mohr I., Jin D. and Kok K.H., Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein, Journal of Virology. 2013, 87: 13141-13149.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1, Cell & Bioscience . 2014, 4: 3.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain, Cellular & Molecular Immunology. 2014, 11: 141-149.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Researcher : Chan CP

Project Title:	Roles of liver-enriched transcription factor CREB-H in liver fibrosis
Investigator(s):	Chan CP, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Chan C.P., The 14th Society of Chinese Bioscientists in America International Symposium Trainee Travel Award, Society of Chinese Bioscientists in America. 2013.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	9th Pan Pacific Connective Tissue Societies Symposium - The extracellular Matrix niche
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2013

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Progenitor cells in the formation and repair of articular cartilage
Investigator(s):	Chan D, Cheah KSE, Chan BP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

List of Research Outputs

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., 1. Chan BP, GCF Chan, Wong HL, Cheung PT, Cheah K, Chan D. Cell-Matrix Microsphere, Associated Products, Methods for Preparation and Applications. US Regular Patent US 8,679,809 B2 (Patent date: 25 Mar 2014), 2014.

Chan B.P., Cheung K.M.C., Chan G.C.F., Chan D. and Hui T.Y., 2. Chan BP, K Cheung, GCF Chan, D Chan, TY Hui. Bioengineered intervertebral disc and Methods for Their Preparation. US Regular Patent US No. 8,734,827. Patent date: 27 May 2014., US Patent Office. 2014.

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., 3. Chan BP, GCF Chan, Wong HL, Cheung PT, Cheah K, Chan D. Cell-Matrix Microsphere, Associated Products, Methods for Preparation and Applications. PCT Patent Application (filed on 18 May 2007) (Chinese Patent Application No. ZL200780018296.8 filed on 19 November 2009) (Patent granted on 18 December 2013), 2013.

Chan C.C.Y., Chan D., Tanner J.A., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of sedlin component of the TRAPP complex in mouse embryonic development, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Chan D., Are there protective genes for disc degeneration?, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation. 2014.

Chan D., Are there protective genes for disc degeneration?, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation, Xi'An, China. 2014.

Chan D., The Hong Kong Genome Wide Association Study: How should we move forward?, Second International Spine Research Sympoisum, Philadelphia, USA. 2013.

Chan D., The Hong Kong Genome Wide Association Study: How should we move forward, Second International Spine Research Sympoisum, Philadelphia. 2013.

Chan W.C.W., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., A Systematic and Simple Scoring System for Histological Analysis of the Mouse Intervertebral Disc during Natural Ageing, Degeneration, and Regeneration, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China May 15-17, 2014.

Chan W.C.W., Cheah K.S.E. and Chan D., Best Oral Presentation (Differentiation and Migration of Endplate Chondrocytes Contribute to the Inner Annulus Fibrosus in Normal and Degenerative Intervertebral Discs) , 9th Pan Pacific Connective Tissue societies Symposium 2014 . 2013.

Chan W.C.W., Au Y.K., Tam V., Cheah K.S.E. and Chan D., Coming together is a beginning: The making of an intervertebral disc, Birth Defects Research Part C: Embryo Today: Reviews. 2014, 102: 83-100.

Cheah K.S.E., Yang L., Tsang K.Y., Tang H.C., Tsang S.W., Yang Y.Z. and Chan D., Lineage extension chondrocytes and the ontogeny of bone cells, The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan, May 27-Jun 1, 2014.. 2014.

Cheah K.S.E., Gao Y., Wong S., Shen M.M. and Chan D., Type IIA Procollagen as a Modulator of Nodal Signaling., 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche Hong Kong Nov 24-27, 2013.. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., AR Hodgson Award - Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study, 33rd Annual Congress of The Hong Kong Orthopaedic Association. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study (Awards session AR Hodgson Winner), 33rd Hong Kong Orthopaedic Association Annual Congress. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association StudyGenome-wide association study of Spinal Stenosis in Southern Chinese: The first of its kind, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong, 2013.

Feng C. and Chan D., Sequential expression of Lgr5 and Coll22a1 in developing synovial joints marks the progressive differentiation of progenitor cells to articular chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Gan H., Zhu G., XUE W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, The Croucher Foundation Advanced Study Institiue: Integrative Approaches to Understanding Disorders of the skeleton. 2013.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse., The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan May 27-30, 2014.. 2014.

LI H.Y., MA J., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional culture system for maintenance of bovine nucleus pulposus cells. , World Forum for Spine Research. May 15-17, 2014, Xi’an, China. . 2014, Page S89.

LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Three-dimensional culture of bovine nucleus pulposus cells in protein matrices. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. 2013, 0055(page 161).

LI Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J., Cheah K.S.E., Chan D. and Sham P.C., Best Short Talk Award, World Forum for Spine Research - Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation, Xian, PR China, May 15-17, 2014. 2014.

LI Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive analysis of MRI-phenotypes provides new insights into lumbar disc degeneration for genetic studies, 41st Annual Meeting of International Society for the Study of the Lumbar Spine, Seoul, Korea, June 3-7, 2014.

LIE Y.S., Chan D. and Cheah K.S.E., Role of autophagy in chondrocyte differentiation , 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In-Vivo Study of Asporin in Cartilage Tissues. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

Li H.Y., Ma J.N., Chooi W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of Three-Dimensional Culture System for Maintenance of Bovine Nucleus Pulposus Cells. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An China, May 15-17 , 2014.. 2014.

Li H.Y., Chooi W.H., Chan D., Cheah K.S.E. and Chan B.P., Three-dimensional Culture of Bovine Nucleus Pulposus Cells in Protein Matrices. , 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong Nov 24-27, 2013.. 2013.

Li Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive Analysis of MRI-Phenotypes Provides New Insights into Lumbar Disc Degeneration for Genetic Studies, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation. Xi'An, China, 2014.

Li Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive analaysis of MRI-phenotypes provides new insights into lumbar disc degeneration for genetic studies, 43rd Annual Meeting of the International Society for the Study of the Lumbar Spine. Seoul, Korea, 2014.

Li Y.Y., Cheng H.W., Cheung K.M.C., Chan D. and Chan B.P., Mesenchymal stem cell-collagen microspheres for articular cartilage repair – Cell density and differentiation status, Acta Biomater . 2014, 10(5): 1919-1929.

Lim F.L., Tam W.K., Au Y.K., Chan D., Cheah K.S.E., Tuan R.S., Cheung K.M.C. and Leung V.Y.L., Cadherin 2 is required for intervertebral disc homeostasis and maintenance of vacuolated phenotype in nucleus pulposus cells, World Forum for Spine Research, Xian, China, May15-17 2014.

Londono D., Kou I., Johnson T.A., Sharma S., Ogura Y., Tsunoda T., Takahashi A., Matsumoto M., Herring J.A., Lam T.P., Wang X., Tam E.M., Song Y., Fan Y., Chan D., Cheah K.S.E., Qiu X., Jiang H., Huang D., Japanese Scoliosis Clinical Research Group ,., TSRHC IS Clinical Group ,., the International Consortium for Scoliosis Genetics ,., Su P., Sham P.C., Cheung K.M.C., Luk K.D.K., Gordon D., Qiu Y. and Cheng J., Tang N., Ikegawa S., Wise C.A., A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. , J Med Genet. . 2014, 51: 401-406.

Lv F., SUN Y., ZHOU L., Lu M., Chan D., Zheng Z., Cheung K.M.C. and Leung V.Y.L., Best Participation Award, World Forum for Spine Research, Xian, China, May 2014. 2014.

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Extracellular Matrix in Planarian Regeneration and Stem Cell Maintenance, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

MA S.K.Y., SHEN Y., Ng V.C.W., Yang A., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., Effect of impaired matrix turnover on differentiation of intervertebral disc cells, 9th Pan Pacific Connective Tissue Symposium, Hong Kong, 24-27th Nov 2013. . 2013.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells, World Forum for Spine Research 2014, Xian, China, 15 - 17th May 2014.

SHEN Y. and Chan D., The role of extracellular matrix in planarian regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Samartzis D., Karppinen J.I., Ala-Korpela M., Soininen P., Kangas A.J., Chan D., Luk K.D.K. and Cheung K.M.C., Best Paper Basic Science Award - Identification of novel serum "metabolomic" biomarkers related to the development of lumbar disc degeneration, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong. . 2013.

Samartzis D., Karppinen J.I., Ala-Korpela M., Soininen P., Kangas A.J., Chan D., Luk K.D.K. and Cheung K.M.C., Identification of novel serum "metabolomic" biomarkers related to the development of lumbar disc degeneration, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong, 2013.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

Sun Y., Tsui Y.K., Masuda K.D.K., Kao R.Y.T., Chan D., Cheung K.M.C. and Leung Y.L.V., Intervening Intervertebral Disc Degeneration By Small Molecules That Positively Modulate Proteoglycan Production, 60th Annual Meeting of Orthopaedic Research Society, 15-18 Mar 2014, New Orleans, USA. 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Modulator of Hedegehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Negative Modulator of Hedgehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 14, 2014.

Tam V., Rogers I., Chan D., Leung Y.L.V. and Cheung K.M.C., A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk, Journal of Orthopaedic Research. 2014, 32: 819-825.

Tang B., FONG M.K., Wen C., Yan C.H., Chan D., Ngan A.H.W., Chiu P.K.Y. and Lu W.W., Nanostiffness of Collagen Fibrils Extracted From Osteoarthritic Cartilage Characterized with AFM Nanoindentation, Soft Materials. 2014, 12: 253-261.

Tsang K.Y., Tsang S.W., Chan D. and Cheah K.S.E., The chondrocytic journey in endochondral bone growth and skeletal dysplasia, Birth Defects Res C Embryo Today. 2014, 102(1): 52-73.

Wang A.M., Cao P., Yee F.Y.A., Chan D. and Wu E.X., Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy, Magn Reson Med. 2014, doi:10.1002/mrm.25289[Epub ahead of print].

XUE W., Gan H., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Involved in Chondrocytes Interaction with Extracellular Matrix, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. . 2013.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

YIP K.H.R., Wu M.H., Hui C.C., Chan D. and Cheah K.S.E., Gli-mediated regulation of Sox9 in limb development., 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong, November 24-27, 2013.. 2013.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YU Y., Chan D., Cheah K.S.E. and Tanner J.A., DNA aptamers can discriminate between closely related aggrecanase drug targets for degenerative disc disease therapy, 50th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery, Rouen, France. 2014.

Yee F.Y.A., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., Analysis Of The Static Protein Profile Of Degenerated Ivd Indicate Increased Fibrosis-related Proteins, World Forum For Spine Research, 2014 (Xian). 2014.

Yee F.Y.A., Tam V., Cheung K.M.C. and Chan D., Proteomics Analysis Of The Human Intervertebral Disc Reveals Potential Fibrotic Events In Degeneration , 9th Pan Pacific Connective Tissue Societies Symposium. 2013.

Yee F.Y.A., Song Y., Chan D. and Cheung K.M.C., Understanding the Basis of Genetic Studies: Adolescent Idiopathic Scoliosis as an Example, Spine Deformity. 2014, 2: 1-9.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. . 2013, 0054(page 132).

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong.. 2013.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation., TERMIS-AP 2013 Annual Conference. October 23-26, 2013, Shanghai-Wuzhen, P. R. China. . 2013, S12-O-1(page 241).

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D configuration for mesenchymal stem cell differentiation, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., SYIS-AP Best Oral Presentation Merit, TERMIS-AP Shanghai & Wuzhen, China. October 23-26, 2013. 2013.

Yuen G.W.Y., Tam V., Leung V.Y.L., Chan D., Lau T.W., Lu W.W. and Leung F.K.L., Defective TGF beta signaling in bisphosphonates associated atypical femoral diaphyseal fracture, The 3rd Scientific Meeting of the Asian Federation of Osteoporosis Societies. 2013.

ZHANG Y., Xiong C., Chan W.C.W., Tam V., Sakai D. and Chan D., Are There Protective Genes for Disc Degeneration? , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., Xiong C., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice., World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., XIONG C., Chan W.C.W., SAKAI D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHANG Y., Chan W.C.W., Sakai D. and Chan D., The Influence of Progenitor Cells in Intervertebral Disc Degeneration and Regeneration , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Chan D.

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	9th Pan Pacific Connective Tissue Societies Symposium - The extracellular Matrix niche
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2013

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Progenitor cells in the formation and repair of articular cartilage
Investigator(s):	Chan D, Cheah KSE, Chan BP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

List of Research Outputs

Researcher : Chan JKM

Project Title:	Establishment of novel approaches to the study of the role of histone post-translational modifications in vivo
Investigator(s):	Chan KMJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

Project Title:	Epigenetics, Chromatin & Transcription; Epigenetics / Histone mutations in Human Disease
Investigator(s):	Chan KMJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014

Researcher : Chan W.L.

Project Title:	Quantitative analysis of TRAPPC2 and TRAPPC9 interaction
Investigator(s):	Chan WL, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

List of Research Outputs

Researcher : Chan WCW

Project Title:	Role of Endogenous Stem/Progenitor cells in the maintenance and regeneration of Intervertebral Discs
Investigator(s):	Chan WCW, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	11/2013

List of Research Outputs

Chan W.C.W., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., A Systematic and Simple Scoring System for Histological Analysis of the Mouse Intervertebral Disc during Natural Ageing, Degeneration, and Regeneration, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China May 15-17, 2014.

Chan W.C.W., Cheah K.S.E. and Chan D., Best Oral Presentation (Differentiation and Migration of Endplate Chondrocytes Contribute to the Inner Annulus Fibrosus in Normal and Degenerative Intervertebral Discs) , 9th Pan Pacific Connective Tissue societies Symposium 2014 . 2013.

Chan W.C.W., Au Y.K., Tam V., Cheah K.S.E. and Chan D., Coming together is a beginning: The making of an intervertebral disc, Birth Defects Research Part C: Embryo Today: Reviews. 2014, 102: 83-100.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., Effect of impaired matrix turnover on differentiation of intervertebral disc cells, 9th Pan Pacific Connective Tissue Symposium, Hong Kong, 24-27th Nov 2013. . 2013.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells, World Forum for Spine Research 2014, Xian, China, 15 - 17th May 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHANG Y., Xiong C., Chan W.C.W., Tam V., Sakai D. and Chan D., Are There Protective Genes for Disc Degeneration? , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., Xiong C., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice., World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., XIONG C., Chan W.C.W., SAKAI D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHANG Y., Chan W.C.W., Sakai D. and Chan D., The Influence of Progenitor Cells in Intervertebral Disc Degeneration and Regeneration , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Chan WL

Project Title:	Quantitative analysis of TRAPPC2 and TRAPPC9 interaction
Investigator(s):	Chan WL, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

List of Research Outputs

Tanner J.A., Bevan S.J., Cheng L.Y.L., Chan W.L. and Wong B.C.W., Promoting deep learning in biochemistry by diversifying assessment strategies – experience at the University of Hong Kong, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SA04-8, 626.

Researcher : Cheah K.S.E.

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

List of Research Outputs

Researcher : Cheah KSE

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates the Lineage Progression of Hypertrophic Chondrocytes, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., 1. Chan BP, GCF Chan, Wong HL, Cheung PT, Cheah K, Chan D. Cell-Matrix Microsphere, Associated Products, Methods for Preparation and Applications. US Regular Patent US 8,679,809 B2 (Patent date: 25 Mar 2014), 2014.

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., 3. Chan BP, GCF Chan, Wong HL, Cheung PT, Cheah K, Chan D. Cell-Matrix Microsphere, Associated Products, Methods for Preparation and Applications. PCT Patent Application (filed on 18 May 2007) (Chinese Patent Application No. ZL200780018296.8 filed on 19 November 2009) (Patent granted on 18 December 2013), 2013.

Chan C.C.Y., Chan D., Tanner J.A., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of sedlin component of the TRAPP complex in mouse embryonic development, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Chan W.C.W., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., A Systematic and Simple Scoring System for Histological Analysis of the Mouse Intervertebral Disc during Natural Ageing, Degeneration, and Regeneration, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China May 15-17, 2014.

Chan W.C.W., Cheah K.S.E. and Chan D., Best Oral Presentation (Differentiation and Migration of Endplate Chondrocytes Contribute to the Inner Annulus Fibrosus in Normal and Degenerative Intervertebral Discs) , 9th Pan Pacific Connective Tissue societies Symposium 2014 . 2013.

Chan W.C.W., Au Y.K., Tam V., Cheah K.S.E. and Chan D., Coming together is a beginning: The making of an intervertebral disc, Birth Defects Research Part C: Embryo Today: Reviews. 2014, 102: 83-100.

Cheah K.S.E., Yang L., Tsang K.Y., Tang H.C., Tsang S.W., Yang Y.Z. and Chan D., Lineage extension chondrocytes and the ontogeny of bone cells, The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan, May 27-Jun 1, 2014.. 2014.

Cheah K.S.E., Resolving the debate about ontogeny of bone cells., Annual International Symposium of BMTRC Seoul, Korea, November 16, 2013.. 2013.

Cheah K.S.E., HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Rizzoti K. and Lovell-Badge R.H., Sox2 regulates hair type specification and pigmentation, Mouse Molecular Genetics, September 18-21, 2013, Cambridge, UK. 2013.

Cheah K.S.E., Transcriptional Control of Sensory Versus Non Sensory Progenitor Specification in the Inner Ear., The 12th Annual Meeting of the International Society for Stem Cell Research Vancourver, Canada, June 18-21, 2014.. 2014.

Cheah K.S.E., Transcriptional control of sensory progenitor specification in the inner ear., 6th Guangzhou International Conference on Stem Cell and Regenerative Medicine Guangzhou, China, December 18-19, 2013.. 2013.

Cheah K.S.E., Gao Y., Wong S., Shen M.M. and Chan D., Type IIA Procollagen as a Modulator of Nodal Signaling., 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche Hong Kong Nov 24-27, 2013.. 2013.

Cheng C.C.W., Warren M., Larysa H.P., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse, Proc Natl Acad Sci USA. 2014, 111(7): 2596-2601.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., AR Hodgson Award - Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study, 33rd Annual Congress of The Hong Kong Orthopaedic Association. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study (Awards session AR Hodgson Winner), 33rd Hong Kong Orthopaedic Association Annual Congress. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association StudyGenome-wide association study of Spinal Stenosis in Southern Chinese: The first of its kind, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong, 2013.

Gan H., Zhu G., XUE W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, The Croucher Foundation Advanced Study Institiue: Integrative Approaches to Understanding Disorders of the skeleton. 2013.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse., The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan May 27-30, 2014.. 2014.

LI H.Y., MA J., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional culture system for maintenance of bovine nucleus pulposus cells. , World Forum for Spine Research. May 15-17, 2014, Xi’an, China. . 2014, Page S89.

LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Three-dimensional culture of bovine nucleus pulposus cells in protein matrices. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. 2013, 0055(page 161).

LI Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J., Cheah K.S.E., Chan D. and Sham P.C., Best Short Talk Award, World Forum for Spine Research - Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation, Xian, PR China, May 15-17, 2014. 2014.

LI Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive analysis of MRI-phenotypes provides new insights into lumbar disc degeneration for genetic studies, 41st Annual Meeting of International Society for the Study of the Lumbar Spine, Seoul, Korea, June 3-7, 2014.

LIE Y.S., Chan D. and Cheah K.S.E., Role of autophagy in chondrocyte differentiation , 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In-Vivo Study of Asporin in Cartilage Tissues. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

Li H.Y., Ma J.N., Chooi W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of Three-Dimensional Culture System for Maintenance of Bovine Nucleus Pulposus Cells. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An China, May 15-17 , 2014.. 2014.

Li H.Y., Chooi W.H., Chan D., Cheah K.S.E. and Chan B.P., Three-dimensional Culture of Bovine Nucleus Pulposus Cells in Protein Matrices. , 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong Nov 24-27, 2013.. 2013.

Li Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive Analysis of MRI-Phenotypes Provides New Insights into Lumbar Disc Degeneration for Genetic Studies, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation. Xi'An, China, 2014.

Li Y., Samartzis D., Campbell D., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Cheah K.S.E., Chan D. and Sham P.C., Comprehensive analaysis of MRI-phenotypes provides new insights into lumbar disc degeneration for genetic studies, 43rd Annual Meeting of the International Society for the Study of the Lumbar Spine. Seoul, Korea, 2014.

Lim F.L., Tam W.K., Au Y.K., Chan D., Cheah K.S.E., Tuan R.S., Cheung K.M.C. and Leung V.Y.L., Cadherin 2 is required for intervertebral disc homeostasis and maintenance of vacuolated phenotype in nucleus pulposus cells, World Forum for Spine Research, Xian, China, May15-17 2014.

Londono D., Kou I., Johnson T.A., Sharma S., Ogura Y., Tsunoda T., Takahashi A., Matsumoto M., Herring J.A., Lam T.P., Wang X., Tam E.M., Song Y., Fan Y., Chan D., Cheah K.S.E., Qiu X., Jiang H., Huang D., Japanese Scoliosis Clinical Research Group ,., TSRHC IS Clinical Group ,., the International Consortium for Scoliosis Genetics ,., Su P., Sham P.C., Cheung K.M.C., Luk K.D.K., Gordon D., Qiu Y. and Cheng J., Tang N., Ikegawa S., Wise C.A., A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. , J Med Genet. . 2014, 51: 401-406.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Modulator of Hedegehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Negative Modulator of Hedgehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 14, 2014.

Tsang K.Y., Tsang S.W., Chan D. and Cheah K.S.E., The chondrocytic journey in endochondral bone growth and skeletal dysplasia, Birth Defects Res C Embryo Today. 2014, 102(1): 52-73.

WEN S., Tan Z., Tsang K.Y., Tsang S.W. and Cheah K.S.E., The Role of Irx3/5 in Regulating Lineage Progression of Hypertrophic Chondrocyte to Osteoblasts , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

XUE W., Gan H., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Involved in Chondrocytes Interaction with Extracellular Matrix, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. . 2013.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

YIP K.H.R., Wu M.H., Hui C.C., Chan D. and Cheah K.S.E., Gli-mediated regulation of Sox9 in limb development., 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong, November 24-27, 2013.. 2013.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H. and Cheah K.S.E., The roles of Sox9 and its regulatory elements in Campomelic Dysplasia. , Embryology: Concepts & Techniques in Modern Developmental Biology, Marine Biological Laboratory, Woods Hole, Massachusetts, US, June 7 – 21, 2014. . 2014.

YU Y., Chan D., Cheah K.S.E. and Tanner J.A., DNA aptamers can discriminate between closely related aggrecanase drug targets for degenerative disc disease therapy, 50th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery, Rouen, France. 2014.

Yee F.Y.A., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., Analysis Of The Static Protein Profile Of Degenerated Ivd Indicate Increased Fibrosis-related Proteins, World Forum For Spine Research, 2014 (Xian). 2014.

Yorgan T., Rendenbach C., Jeschke A., Amling M., Cheah K.S.E. and Schinke T., Increased Col10a1 expression is not causative for the phenotype of Phex-deficient Hyp mice, Biochem Biophys Res Commun. 2013, 442: 209-213.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. . 2013, 0054(page 132).

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong.. 2013.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation., TERMIS-AP 2013 Annual Conference. October 23-26, 2013, Shanghai-Wuzhen, P. R. China. . 2013, S12-O-1(page 241).

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D configuration for mesenchymal stem cell differentiation, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., SYIS-AP Best Oral Presentation Merit, TERMIS-AP Shanghai & Wuzhen, China. October 23-26, 2013. 2013.

Researcher : Cheng CCW

List of Research Outputs

Cheah K.S.E., HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Rizzoti K. and Lovell-Badge R.H., Sox2 regulates hair type specification and pigmentation, Mouse Molecular Genetics, September 18-21, 2013, Cambridge, UK. 2013.

Cheng C.C.W., Warren M., Larysa H.P., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse, Proc Natl Acad Sci USA. 2014, 111(7): 2596-2601.

Researcher : Cheng LYL

Project Title:	A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community
Investigator(s):	Cheng LYL, Tan-Un KC
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

List of Research Outputs

Tanner J.A., Bevan S.J., Cheng L.Y.L., Chan W.L. and Wong B.C.W., Promoting deep learning in biochemistry by diversifying assessment strategies – experience at the University of Hong Kong, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SA04-8, 626.

Researcher : Cheung HYZ

Project Title:	Identification of novel autophagy regulators in neurons
Investigator(s):	Cheung HYZ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013
Completion Date:	04/2014

Project Title:	Deciphering the molecular machinery of autophagy deregulation in Parkinsons disease
Investigator(s):	Cheung HYZ
Department:	Biochemistry
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2014
Completion Date:	11/2013

Researcher : Cheung MCH

Project Title:	In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development
Investigator(s):	Cheung MCH, Zhou G
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	In vivo identification and characterization of cis-regulatory elements and upstream effectors to control Sox9 expression at the onset of neural crest specification
Investigator(s):	Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012
Completion Date:	09/2013

Project Title:	Avian Model Systems; BMP and canonical Wnt signaling regulate neural crest delamination by controlling Sox9 phosphorylation and its interaction with Snail2
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014
Completion Date:	03/2014

Project Title:	Investigating the roles of SOX9 in human neural stem cells
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Modulator of Hedegehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Negative Modulator of Hedgehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 14, 2014.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H. and Cheah K.S.E., The roles of Sox9 and its regulatory elements in Campomelic Dysplasia. , Embryology: Concepts & Techniques in Modern Developmental Biology, Marine Biological Laboratory, Woods Hole, Massachusetts, US, June 7 – 21, 2014. . 2014.

ZHENG F., Li T., Cheung M.C.H., Syrovatkina V. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips. , FEBS Lett . 2014, 588(6): 859-865.

Researcher : Cheung YW

List of Research Outputs

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium. 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

Researcher : Chu KH

List of Research Outputs

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : DIRKZWAGER RM

List of Research Outputs

DIRKZWAGER R.M. and Tanner J.A., A Novel Aptamer-Based Enzymatic Assay for the Diagnosis of Malaria, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium. 2014.

DIRKZWAGER R.M., Cheung Y.W. and Tanner J.A., Best Poster Prize - A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Best Poster Prize - Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

Tanner J.A., CHEUNG Y.W., DIRKZWAGER R.M., KINGHORN A.B. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis – discovery, characterization, structure and application, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SW01.W5-30, 87.

Researcher : Danchin ALM

List of Research Outputs

Danchin A.L.M. and Sekowska A., Constraints in the design of the synthetic bacterial chassis, Methods in Microbiology (Chapter 2). 2013, 40.

Researcher : Deng J

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : FAN W

List of Research Outputs

FAN W., Lu X., Yao K.M. and Huang W., Toward Exploring Pluripotency Landscape Through Light-induced Tuning of Oct4 Expression, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : FAN Y

List of Research Outputs

FAN Y., Genome-wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese and Significant Improvement in Detection of Missing heritability and Genetic Risk Prediction in Genome–wide Association Studies by 1000 Genomes-based Imputation, PhD Thesis, The University of Hong Kong. 2013.

Londono D., Kou I., Johnson T.A., Sharma S., Ogura Y., Tsunoda T., Takahashi A., Matsumoto M., Herring J.A., Lam T.P., Wang X., Tam E.M., Song Y., Fan Y., Chan D., Cheah K.S.E., Qiu X., Jiang H., Huang D., Japanese Scoliosis Clinical Research Group ,., TSRHC IS Clinical Group ,., the International Consortium for Scoliosis Genetics ,., Su P., Sham P.C., Cheung K.M.C., Luk K.D.K., Gordon D., Qiu Y. and Cheng J., Tang N., Ikegawa S., Wise C.A., A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. , J Med Genet. . 2014, 51: 401-406.

Researcher : Fan Y

List of Research Outputs

Researcher : Feng C

List of Research Outputs

Feng C. and Chan D., Sequential expression of Lgr5 and Coll22a1 in developing synovial joints marks the progressive differentiation of progenitor cells to articular chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Fu C

Project Title:	Role of the interaction between psr1p and TACC/alp7p in spindle assembly
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013
Completion Date:	03/2014

Project Title:	Roles of a novel spindle pole body protein psr1p in bipolar spindle assembly and kinetochore clustering
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2013

Project Title:	The role of kinesin-8 in anaphase B spindle elongation
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014

List of Research Outputs

Costa J., Fu C., Syrovatkina V. and Tran P.T., Imaging individual spindle microtubule dynamics in fission yeast, Methods in Cell Biology. Elsevier, 2013, 115: 385-394.

Li T. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Syrovatkina V., Fu C. and Tran P.T., Antagonistic Spindle Motors and MAPs Regulate Metaphase Spindle Length and Chromosome Segregation, Current Biology. 2013.

ZHENG F. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHENG F., Li T., Cheung M.C.H., Syrovatkina V. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips. , FEBS Lett . 2014, 588(6): 859-865.

Researcher : GAO W

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Gao W. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1 , 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Lo I.F.M., Leung K.C., Luk H.M., Tang V.H.M., Gao W., Wong W.L., Tang L.Y.F., Chu W.Y., Kan S.Y.A., Tang M.H.Y., Lam S.T.S., Yang W., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Identifying genetic mutations in patients with RASopathies using a new generation sequencing diagnostic pipeline in Hong Kong, Annual Scientific Meeting, Hong Kong College of Paediatricians, HK, 7 December 2013. 19.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

Researcher : GHOSH S

List of Research Outputs

GHOSH S. and Zhou Z., Role of nuclear lamins in the regulation of SIRT6, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Ghosh S. and Zhou Z., Genetics of aging, progeria and lamin disorders, Current Opinion in Genetics & Development. 2014, 26: 41-46.

Researcher : Gan H

List of Research Outputs

Gan H., Zhu G., XUE W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, The Croucher Foundation Advanced Study Institiue: Integrative Approaches to Understanding Disorders of the skeleton. 2013.

XUE W., Gan H., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Involved in Chondrocytes Interaction with Extracellular Matrix, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. . 2013.

Researcher : Gao W

List of Research Outputs

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

Researcher : Gao Y

List of Research Outputs

Cheah K.S.E., Gao Y., Wong S., Shen M.M. and Chan D., Type IIA Procollagen as a Modulator of Nodal Signaling., 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche Hong Kong Nov 24-27, 2013.. 2013.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells. , 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong. . 2013, 0054(page 132).

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, 9th Pan Pacific Connective Tissue Societies Symposium – The Extracellular Matrix Niche. November 24-27, 2013, Hong Kong.. 2013.

Yuan M., Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Development of three-dimensional system for culturing notochordal cells, TERMIS-AP, October 23-26, 2013, Shanghai & Wuzhen, China.. 2013.

Researcher : Ghosh S

List of Research Outputs

Ghosh S. and Zhou Z., Genetics of aging, progeria and lamin disorders, Current Opinion in Genetics & Development. 2014, 26: 41-46.

Researcher : Guo S

Project Title:	47th Annual Meeting for the Japanese Society of Developmental Biologists; Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse
Investigator(s):	Guo S
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014

List of Research Outputs

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse., The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan May 27-30, 2014.. 2014.

Researcher : HO BS-Y

List of Research Outputs

Cheah K.S.E., HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Rizzoti K. and Lovell-Badge R.H., Sox2 regulates hair type specification and pigmentation, Mouse Molecular Genetics, September 18-21, 2013, Cambridge, UK. 2013.

Researcher : HO TH

List of Research Outputs

HO T.H., Immunostimulatory function of the defective interfering RNA of Sendai virus, MPhil Thesis, The University of Hong Kong. 2013.

Researcher : HOR HH

List of Research Outputs

WANG B., Wong Y.M.E., HOR H.H., Hui C.C. and Sham M.H., Gli3 repressor is required to mediate the timing of mammalian cochlear hair cell differentiation., The 47th Annual Meeting of the Japanese Society of Developmental Biologists, Nogoya, Japan, May 28-30, 2014.

XU Y., Hor H.H., Hui C.C. and Sham M.H., The role of Suppressed of Fused in neural stem cell proliferation, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : HU J

List of Research Outputs

HU J., Bitter P., Jonas F., Lu X., Li S.H., Sham M.H., Huang W., Lenz P. and Huang W., A Novel Non-Turing Mechanism of Spot Pattern Formation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative characterization of mesencymal cell aggregation. , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

LU X., LI S., HU J., Huang J. and Huang W., Quantitative Characterization of Mouse Embryonic Stem Cell Self-renewal, Differentiation and Dedifferentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : HU X

List of Research Outputs

HU X. and Zhou Z., UHRF1 in Hedgehog signalling and basal cell carcinoma, 2nd HEALING International Meeting on Hh-Gli Signalling in Stem cells, Regeneration and Cancer. Arolla, Switzerland. 2013.

Researcher : HUA Y

List of Research Outputs

HUA Y., Zhang B., Liu C.Y., Cai J. and Huang J., Development of a Virosome Vaccine against Aspergillus Fumigatus , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : HUI MN

List of Research Outputs

HUI M.N., Investigating the Role of SoX9 in Human Neural Stem Cells , MPhil Thesis, The University of Hong Kong. 2013.

Researcher : Ho DWH

Project Title:	Integrative investigation of somatic copy number and gene expression alterations in human hepatocellular carcinoma
Investigator(s):	Ho DWH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

Researcher : Ho JWY

List of Research Outputs

Ho J.W.Y., Chan L.K. and Sham M.H., Confronting the challenges of biochemistry teaching and learning in the medical curriculum, Frontiers in Medical and Health Sciences Education,6-7 December 2013, Hong Kong. 2013.

Researcher : Hor HH

List of Research Outputs

XU Y., Hor H.H., Hui C.C. and Sham M.H., The role of Suppressed of Fused in neural stem cell proliferation, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011
Completion Date:	12/2013

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011
Completion Date:	02/2014

Project Title:	Quantitative characterization of mouse embryonic stem cell self- renewal, differentiation and dedifferentiation
Investigator(s):	Huang J, Huang W
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Guiding the immune response: a novel approach for HIV-1 vaccine development
Investigator(s):	Huang J, Zhang M
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Engineer bacterial cell shape
Investigator(s):	Huang J, Liu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013
Completion Date:	04/2014

Project Title:	Development of subunit vaccine against Staphylococcus aureus infections
Investigator(s):	Huang J, Zhang B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013
Completion Date:	06/2014

Project Title:	The 21st international conference on Intelligent Systems for Molecular Biology (ISMB); Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013
Completion Date:	07/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2014

Project Title:	Regulation of epithelial cell proliferation by mechanical force
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Chen W., Cheng T., Huang J. and Watt R.M., Dissection of biophysical properties and biological activities of Bet/RecT family DNA recombination proteins, Society of General Microbiology Annual Conference, Liverpool UK, 2014.

Durairajan S.S.K., Yuen Y., Chen L.L., Kwok K.Y., Liu L.F., Song J.X., Han Q.B., Xue L., Chung S.K., Huang J. and Li M., Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models. , PLoS ONE . 2014, 9(3): e92954.

Gan H., Zhu G., XUE W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, The Croucher Foundation Advanced Study Institiue: Integrative Approaches to Understanding Disorders of the skeleton. 2013.

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative characterization of mesencymal cell aggregation. , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

HUA Y., Zhang B., Liu C.Y., Cai J. and Huang J., Development of a Virosome Vaccine against Aspergillus Fumigatus , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, IAS Workshop on Statistical Physics and Computational Neuroscience, The Hong Kong University of Science and Technology. 2013.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Imperial College, Hammersmith Campus, London. 2013.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, The Wellcome Trust Sanger Institute, Hinxton, UK. 2013.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Yale University, New Haven, Connecticut, USA.. 2013.

Jin Y., Wu J.T., Cai Z.M. and Huang J., Modification of the RpoS network with an artificial small RNA., Nucleic Acids Research. 2013, V41(17): 8332-8340.

Jin Y. and Huang J., Portable Two-Way Riboswitches: Design and Engineering in Artificial Riboswitches, In: Atsushi Ogawa, Methods and Protocols, Series: Methods in Molecular Biology. A product of Humana Press, 2014, 1111: 93-106.

LIN Q. and Huang J., Mechanistic Study of Salmonella-induced Reduction of Cancer Metastasis , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LIU M. and Huang J., Mechanical Force Controlled Epithelial Morphogenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LU X., LI S., HU J., Huang J. and Huang W., Quantitative Characterization of Mouse Embryonic Stem Cell Self-renewal, Differentiation and Dedifferentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Lin S.H., Kanawati B., Liu L.F., Witting M., Li M., Huang J., Schmitt-Kopplin P. and Cai Z.W., Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models., Talanta. 2014, V118: 45-53.

Liu L. and Huang J., Gene Expression Noise in Transcriptional Negative Auto-regulation in Mammalian Cell, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

XUE W., Gan H., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Involved in Chondrocytes Interaction with Extracellular Matrix, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. . 2013.

ZHAO Y. and Huang J., Cyst formation: Mathematical Model and Data Analysis, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Huang J.

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011
Completion Date:	12/2013

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011
Completion Date:	02/2014

Project Title:	Quantitative characterization of mouse embryonic stem cell self- renewal, differentiation and dedifferentiation
Investigator(s):	Huang J, Huang W
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Guiding the immune response: a novel approach for HIV-1 vaccine development
Investigator(s):	Huang J, Zhang M
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Engineer bacterial cell shape
Investigator(s):	Huang J, Liu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013
Completion Date:	04/2014

Project Title:	Development of subunit vaccine against Staphylococcus aureus infections
Investigator(s):	Huang J, Zhang B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013
Completion Date:	06/2014

Project Title:	The 21st international conference on Intelligent Systems for Molecular Biology (ISMB); Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013
Completion Date:	07/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2014

Project Title:	Regulation of epithelial cell proliferation by mechanical force
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Researcher : Huang W

List of Research Outputs

FAN W., Lu X., Yao K.M. and Huang W., Toward Exploring Pluripotency Landscape Through Light-induced Tuning of Oct4 Expression, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

HU J., Bitter P., Jonas F., Lu X., Li S.H., Sham M.H., Huang W., Lenz P. and Huang W., A Novel Non-Turing Mechanism of Spot Pattern Formation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative characterization of mesencymal cell aggregation. , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

LU X., LI S., HU J., Huang J. and Huang W., Quantitative Characterization of Mouse Embryonic Stem Cell Self-renewal, Differentiation and Dedifferentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Hui CC

List of Research Outputs

LIU Y., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear sensorineural patterning , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

WANG B., Wong Y.M.E., HOR H.H., Hui C.C. and Sham M.H., Gli3 repressor is required to mediate the timing of mammalian cochlear hair cell differentiation., The 47th Annual Meeting of the Japanese Society of Developmental Biologists, Nogoya, Japan, May 28-30, 2014.

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

WANG B., Wong Y.M.E., Liu Y., Hui C.C. and Sham M.H., Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

XU Y., Hor H.H., Hui C.C. and Sham M.H., The role of Suppressed of Fused in neural stem cell proliferation, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

YIP K.H.R., Wu M.H., Hui C.C., Chan D. and Cheah K.S.E., Gli-mediated regulation of Sox9 in limb development., 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong, November 24-27, 2013.. 2013.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis
Investigator(s):	Jin D, Ching YP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Roles of dsRNA-binding protein PACT in RIG-I dependent innate antiviral immunity
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010
Completion Date:	09/2013

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Construction of miR-BART microRNA-deficient Epstein-Barr viruses in bacterial artificial chromosomes using recombineering in E. coli and characterization of recombinant viruses in nasopharyngeal epithelial cells
Investigator(s):	Jin D, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2014

Project Title:	Molecular mechanisms of innate antiviral response
Investigator(s):	Jin D, Kok KH, Lau ASY, Sham MH, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

Project Title:	Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis
Investigator(s):	Jin D, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2012

Project Title:	Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013

Project Title:	Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells
Investigator(s):	Jin D, Huang J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription
Investigator(s):	Jin D, Zheng B, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Anti-hepatitis B virus activity of Resveratrol and mechanism of action
Investigator(s):	Jin D, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Molecular Mechanisms of Innate Immunity
Investigator(s):	Jin D, Lu L, Lau ASY, Tu W
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	06/2013

Project Title:	Roles of SIRT1 deacetylase in human T-cell leukemia virus type I transcription and leukemogenesis
Investigator(s):	Jin D, Ching YP, Tu W
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription
Investigator(s):	Jin D, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Mechanism of inflammasome activation by SARS coronavirus 3a protein
Investigator(s):	Jin D, Zheng B, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Metabolism, Diet and Disease 2014: Cancer and Metabolism ; CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014
Completion Date:	05/2014

Project Title:	Characterization of a novel cGAMP-hydrolyzing phosphodiesterase encoded by Middle East respiratory syndrome coronavirus
Investigator(s):	Jin D, Tse H
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Immunostimulatory RNA in live attenuated measles vaccine
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47.

Chan C.P., Jin D. and Kok K.H., Influenza A virus NS1 protein suppresses innate antiviral immune response by preventing PACT-induced activation of RIG-I , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Chan C.P., Kok K.H., Tang V.H.M., Wong C.M. and Jin D., Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013, 1833: 2165-2175.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Gao W. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1 , 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Jin D., Croucher Senior Research Fellowship (Croucher Award, 2014), Croucher Foundation. 2014.

Jin D., Subversion of innate antiviral immune response by Middle East respiratory syndrome coronavirus , The 4th Cross Straight Immunology Conference, National Yang Ming University, Taipei, Taiwan, April 28-29, 2014.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KEW C., LUI P.Y., Chan C.P., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes simplex virus type 1 Us11 protein inhibits type I interferon production by suppressing PACT mediated activation of RIG-I , The 5th EMBO Meeting 2013, Amsterdam, The Netherlands, September 21-24, 2013.

KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W., Mohr I., Jin D. and Kok K.H., Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein, Journal of Virology. 2013, 87: 13141-13149.

KONG K.Y., Tang V.H.M., Pan K., HUANG Z., LEE T.H.J., Hinnebusch A., Jin D. and Wong C.M., Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing, Nucleic Acids Research. Oxford Journals, 2014, 42: 643-660.

Kok K.H. and Jin D., Balance of Power in Host-Virus Arms Races, Cell Host & Microbe. 2013, 14: 5-6.

Kok K.H., Au S.W.N. and Jin D., Differential roles of RNA-binding proteins TRBP and PACT in RNA silencing and sensing, The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.. 2013.

LUI P.Y., Kok K.H. and Jin D., The Double-stranded RNA-binding Protein PACT Activates Cytoplasmic Viral Sensor MDA5 by Promoting its Oligomerization , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LUI P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT activates cytoplasmic viral sensor MDA5 by promoting its oligomerization , The American Society for Virology 33rd Annual Meeting, Colorado State University, Fort Collins, Colorado, USA, June 21-25, 2014.

Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690.

Lee M.Y., Kok K.H., Jaume M.D.A., Cheung K.W., Yip T.F., Lai J.C.C., Guan Y., Webster R.G., Jin D. and Peiris J.S.M., Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection, Proceedings of the National Academy of Sciences of the United States of America. 2014, 111(10): 3793-8.

Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744.

Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87.

Lo I.F.M., Leung K.C., Luk H.M., Tang V.H.M., Gao W., Wong W.L., Tang L.Y.F., Chu W.Y., Kan S.Y.A., Tang M.H.Y., Lam S.T.S., Yang W., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Identifying genetic mutations in patients with RASopathies using a new generation sequencing diagnostic pipeline in Hong Kong, Annual Scientific Meeting, Hong Kong College of Paediatricians, HK, 7 December 2013. 19.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1, Cell & Bioscience . 2014, 4: 3.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain, Cellular & Molecular Immunology. 2014, 11: 141-149.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

WANG L., Kwong Y.L., Wong K.F., Kho C.S.B., Jin D., Tse E.W.C., Rosen A. and Chim J.C.S., Epigenetic inactivation of miR-34b/c in addition to miR-34a and DAPK1 in chronic lymphocytic leukemia, J Transl Med. 2014, 12(1): 52.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., Roles of a novel splice variant of human IFI16 in innate immune response, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764.

Wang L.Q., Kwong Y.L., Wong K.F., Kho C.S.B., Jin D., Tse E.W.C., Rosen A. and Chim J.C.S., Epigenetic inactivation of miR-34b/c in addition to miR-34a and DAPK1 in chronic lymphocytic leukemia, Journal of Translational Medicine. 2014, 12: 52-61.

YUEN K.S., Tang H.M.V., Kok K.H. and Jin D., Roles of Epstein-Barr Virus-encoded miR-BART microRNAs in Nasopharyngeal Epithelial Tumorigenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Jin Y

List of Research Outputs

Jin Y., Wu J.T., Cai Z.M. and Huang J., Modification of the RpoS network with an artificial small RNA., Nucleic Acids Research. 2013, V41(17): 8332-8340.

Jin Y. and Huang J., Portable Two-Way Riboswitches: Design and Engineering in Artificial Riboswitches, In: Atsushi Ogawa, Methods and Protocols, Series: Methods in Molecular Biology. A product of Humana Press, 2014, 1111: 93-106.

Researcher : KEW C

List of Research Outputs

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KEW C., LUI P.Y., Chan C.P., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes simplex virus type 1 Us11 protein inhibits type I interferon production by suppressing PACT mediated activation of RIG-I , The 5th EMBO Meeting 2013, Amsterdam, The Netherlands, September 21-24, 2013.

KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W., Mohr I., Jin D. and Kok K.H., Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein, Journal of Virology. 2013, 87: 13141-13149.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Researcher : KHONG ML

List of Research Outputs

KHONG M.L. and Tanner J.A., Inorganic Polyphosphate as a Forgotten Molecule in Osteoblasts - From Synthesis to Function, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate as a ‘forgotten’ molecule in osteoblasts – from synthesis to function, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

Researcher : KINGHORN AB

List of Research Outputs

KINGHORN A.B. and Tanner J.A., Aptamer library resampling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KINGHORN A.B. and Tanner J.A., Aptamer library resampling, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

Tanner J.A., CHEUNG Y.W., DIRKZWAGER R.M., KINGHORN A.B. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis – discovery, characterization, structure and application, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SW01.W5-30, 87.

Researcher : KONG KY

List of Research Outputs

KONG K.Y., Characterization of the roles of yeast nuclear exosome cofactor TRAMP complex in pre-mRNA splicing , PhD Thesis, The University of Hong Kong. 2013.

KONG K.Y., Tang V.H.M., Pan K., HUANG Z., LEE T.H.J., Hinnebusch A., Jin D. and Wong C.M., Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing, Nucleic Acids Research. Oxford Journals, 2014, 42: 643-660.

Researcher : KWAN PY

List of Research Outputs

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Best Poster Presentation Award, 9th Pan Pacific Connective Tissue Societies Symposium. 2013. 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Certificate of Merit (Oral Presentation of poster), Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK.2014. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Outstanding Abstract Prize (Poster Category) , Ninth International Symposium on Healthy Aging. 2014. 2014.

KWAN P.Y., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates and semaphorin 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium. 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal Maturation of the Vestibular Circuit for Gravity Detection by under the Regulation of Perineuronal Chondroitin Sulfates and Semaphorin 3A , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th FENS Forum of Neuroscience,2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphoring 3A in the developmental maturation of the central vestibular circuitry, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A Associated with Chondroitin Sulfates on Perineuronal Nets Regulates Developmental Maturation of the Central Vestibular Circuitry. , Ninth International Symposium on Healthy Aging. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulfate proteoglycan networks of perineuronal nets regulate developing central vestibular circuitry, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association69. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulphate proteoglycan networks of perineuronal nets regulate the developing central vestibular circuitry, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 69. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin3A, Associated with Perineuronal Nets, Regulates the Development of the Maturation of the Central Vestibular Circuitry, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets and semaphorin 3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th Int’l Symp. on Healthy Aging: 75. 2014.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal chondroitin sulfates and semaphoring 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium P30. [HK. Nov. 24-27, 2013]. 2013.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal maturation of the vestibular circuit for gravity detection is regulated by perineuronal semaphoring 3A and chondroitin sulfates, Proc. International Symposium on Physiomics p.74. 2013.

Researcher : KWOK CTD

List of Research Outputs

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the Role of FoxM1 in the Maintenance of Human Embryonic Stem Cell Pluripotency , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

LEUNG M.H., KWOK C.T.D., Liu B., Lee C.Y.L. and Yao K.M., Investigating the Protective Role of FOXM1 against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LEUNG M.H., KWOK C.T.D., Lee C.Y.L. and Yao K.M., Investigating the protective role of FOXM1 against oxidative stress and DNA damage in human embryonic stem cells, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013.

Researcher : Kao PYP

List of Research Outputs

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., AR Hodgson Award - Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study, 33rd Annual Congress of The Hong Kong Orthopaedic Association. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study (Awards session AR Hodgson Winner), 33rd Hong Kong Orthopaedic Association Annual Congress. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association StudyGenome-wide association study of Spinal Stenosis in Southern Chinese: The first of its kind, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong, 2013.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

Researcher : Kew C

List of Research Outputs

Researcher : Kok KH

Project Title:	Modulation of RIG-I virus sensor by an Esptein-Barr virus-encoded microRNA
Investigator(s):	Kok KH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2012

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Characterization of the interferon-antagonizing activity of NSs protein encoded by severe febrile and thrombocytopenic syndrome virus (SFTSV), a newly identified phlebovirus associated with an emerging infectious disease
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012
Completion Date:	12/2013

Project Title:	Role of PACT in host antiviral defence against influenza A virus
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Roles of PACT in the induction of type I interferon by measles virus defective interring RNA
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Characterization of an alternatively spliced tumor suppressor FAT1 in hepatocellular carcinoma
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

List of Research Outputs

Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47.

Chan C.P., Jin D. and Kok K.H., Influenza A virus NS1 protein suppresses innate antiviral immune response by preventing PACT-induced activation of RIG-I , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Chan C.P., Kok K.H., Tang V.H.M., Wong C.M. and Jin D., Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013, 1833: 2165-2175.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KEW C., LUI P.Y., Chan C.P., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes simplex virus type 1 Us11 protein inhibits type I interferon production by suppressing PACT mediated activation of RIG-I , The 5th EMBO Meeting 2013, Amsterdam, The Netherlands, September 21-24, 2013.

KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W., Mohr I., Jin D. and Kok K.H., Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein, Journal of Virology. 2013, 87: 13141-13149.

Kok K.H. and Jin D., Balance of Power in Host-Virus Arms Races, Cell Host & Microbe. 2013, 14: 5-6.

Kok K.H., Au S.W.N. and Jin D., Differential roles of RNA-binding proteins TRBP and PACT in RNA silencing and sensing, The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.. 2013.

LUI P.Y., Kok K.H. and Jin D., The Double-stranded RNA-binding Protein PACT Activates Cytoplasmic Viral Sensor MDA5 by Promoting its Oligomerization , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LUI P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT activates cytoplasmic viral sensor MDA5 by promoting its oligomerization , The American Society for Virology 33rd Annual Meeting, Colorado State University, Fort Collins, Colorado, USA, June 21-25, 2014.

Lee M.Y., Kok K.H., Jaume M.D.A., Cheung K.W., Yip T.F., Lai J.C.C., Guan Y., Webster R.G., Jin D. and Peiris J.S.M., Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection, Proceedings of the National Academy of Sciences of the United States of America. 2014, 111(10): 3793-8.

Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744.

Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1, Cell & Bioscience . 2014, 4: 3.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain, Cellular & Molecular Immunology. 2014, 11: 141-149.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

WANG P., Siu K.L., Yang W., Zhang Y. and Kok K.H., Roles of a Novel Splice Variant of Human IFI16 in Innate Immune Response , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., Roles of a novel splice variant of human IFI16 in innate immune response, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

YUEN K.S., Tang H.M.V., Kok K.H. and Jin D., Roles of Epstein-Barr Virus-encoded miR-BART microRNAs in Nasopharyngeal Epithelial Tumorigenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Kudelko MA

Project Title:	Comparative proteomic study of normal and dysplasic hypertrophic cartilage to unravel in vivo specific components involved in skeletal dysplasias
Investigator(s):	Kudelko MA, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2013
Completion Date:	12/2013

Researcher : Kwan PY

List of Research Outputs

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Best Poster Presentation Award, 9th Pan Pacific Connective Tissue Societies Symposium. 2013. 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Certificate of Merit (Oral Presentation of poster), Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK.2014. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Outstanding Abstract Prize (Poster Category) , Ninth International Symposium on Healthy Aging. 2014. 2014.

Researcher : Kwok LF

List of Research Outputs

Kwok L.F. and Shum D.K.Y., CHONDROITINASE ABC-I AND –II LINKED CHITOSAN MICROBEADS INCREASE NEURTIRE LENGTH IN CSPG-ENRICHED ASTROCYTE CULTURE., 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Ninth International Symposium on Healthy Aging. 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 9^th Int’l Symp. on Healthy Aging: Aging with Confidence: 73. 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II linked chitosan microbeads improve axonal regrowth in CSPG-upregulated astrocyte culture, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Kwok L.F., Use of Schwann cell-seeded nanofiber as nerve conduit, 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies. 2014.

Researcher : Kwong WH

Project Title:	The role of Smad4 in cochlear development in mouse
Investigator(s):	Kwong WH, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011

Researcher : LAM HC

List of Research Outputs

LAM H.C., Investigation of PTPN21 in ErbBs signaling transduction and its potential biological function, PhD Thesis, The University of Hong Kong. 2013.

Researcher : LAU WY

List of Research Outputs

LAU W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9^th FENS Forum of Neuroscience777. [Milan, Italy. July 5-9, 2014] . 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Neuronal expression of heparanase 1 and heparanase 2, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 71. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 71, Neuronal expression of heparanase 1 and heparanase 2. 2014.

Researcher : LEUNG HY

List of Research Outputs

LEUNG H.Y. and LEUNG H.Y., A study of membrane-bound neuregulin in mediating fate commitment of Schwann cell-like cells , MPhil Thesis, The University of Hong Kong. 2013.

LEUNG H.Y., TSUI Y.P., Tai E.W.Y., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, European meeting on Glial Cells in Health and Disease. 2013.

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014.

Researcher : LEUNG MH

List of Research Outputs

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the Role of FoxM1 in the Maintenance of Human Embryonic Stem Cell Pluripotency , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

LEUNG M.H., KWOK C.T.D., Liu B., Lee C.Y.L. and Yao K.M., Investigating the Protective Role of FOXM1 against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LEUNG M.H., KWOK C.T.D., Lee C.Y.L. and Yao K.M., Investigating the protective role of FOXM1 against oxidative stress and DNA damage in human embryonic stem cells, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013.

Researcher : LI J

List of Research Outputs

LI J., Yan B., Sham P.C. and Wang J.J., Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression, Briefings in Bioinformatics. 2014.

LI J., Wang Y., Xia Z.Y., Sham P.C. and Wang J.J., GWAS3D: Detecting Human Regulatory Variants by Integrative Analysis of Genome-wide Associations and Chromosome States , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, Nucleic Acids Res. 2013, 41(W1): W150-W158.

LI J., WANG Y., Zhang M.Q. and Wang J.J., Systematic analysis of the role of transcription regulators in distal interactions., The Gordon Research Conference (GRC) on "Post-translational Modification Networks – Phospho-signaling", The Hong Kong University of Science & Technology, Hong Kong, 28 Aug 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., The best poster presentation award, The 5th International Conference on Computational and Systems Biology, SUSTC, Shenzhen, Nov15, 2013 . 2013.

LI J., WANG Y. and Wang J.J., dbPSHP: a database of recent positive selection across human population, The 5th Annual International Conference on Computational and Systems Biology (ICCSB2013), Shenzhen, China, 14-16 November 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

QIN J., LI J., WANG P., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high-throughput proteomic and transcriptome data., 21st Annual International Conference on Intelligent Systems for Molecular Biology and 12th European Conference on Computational Biology, Berlin, Germany, 19-23 July 2013.. 2013.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

WANG W., XU F., WANG P., LI J., Sham P.C. and Wang J.J., Assessment of Aligner and SNP Caller for Next Generation Sequencing and a Fast and Accurate SNP Detection Method., The 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2013) and the 12th Annual European Conference on Computational Biology (ECCB), Berlin, Germany,19-23 July, 2013.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

WANG Y., LI J. and Wang J.J., Analysis of long-range chromatin interaction and how transcription factors are involved to regulate gene expression, Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor Laboratory, New York, US, 18-22 March 2014.

Wang P., Lai W.F., Li J., Xu F., Yalamanchili H.K., Lovell-Badge R. and Wang J.J., Inference of Gene-Phenotype Associations via Protein-Protein Interaction and Orthology, PLoS One. 2013, 8(10): e77478.

YALAMANCHILI H.K., Yan B., LI J., Qin J., Zhao Z., Chin F.Y.L. and Wang J.J., DDGni: Dynamic Delay Gene Network Inference from High Temporal Data using Gapped Local Alignment, Bioinformatics. 2013, 30(3): 377-383.

YALAMANCHILI H.K., Yan B., LI J., QIN J., Zhao Z., Chin F.Y.L. and Wang J.J., Inferring Gene Regulatory Network from Variable Delay High Temporal Data. , The 21st Annual International Conference on Intelligent Systems for Molecular Biology / 12th Annual European Conference on Computational Biology (ISMB/ECCB 2013), Berlin, Germany, 21-23 July 2013.. 2013.

Researcher : LI Z

List of Research Outputs

LI Z., Leung C., Zhang M., Sit H.M. and Sham M.H., The role of Sox10 in enteric neural crest cell migration, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : LIANG S

List of Research Outputs

LIANG S. and Tanner J.A., Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

LIANG S., Dhillo W., Cass T. and Tanner J.A., Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

Researcher : LIE YS

List of Research Outputs

LIE Y.S., Chan D. and Cheah K.S.E., Role of autophagy in chondrocyte differentiation , 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : LIN Q

List of Research Outputs

LIN Q. and Huang J., Mechanistic Study of Salmonella-induced Reduction of Cancer Metastasis , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : LIU M

List of Research Outputs

LIU M. and Huang J., Mechanical Force Controlled Epithelial Morphogenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : LIU Y

List of Research Outputs

LIU Y., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear sensorineural patterning , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

WANG B., Wong Y.M.E., Liu Y., Hui C.C. and Sham M.H., Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : LU X

List of Research Outputs

FAN W., Lu X., Yao K.M. and Huang W., Toward Exploring Pluripotency Landscape Through Light-induced Tuning of Oct4 Expression, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

HU J., Bitter P., Jonas F., Lu X., Li S.H., Sham M.H., Huang W., Lenz P. and Huang W., A Novel Non-Turing Mechanism of Spot Pattern Formation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

LU X., LI S., HU J., Huang J. and Huang W., Quantitative Characterization of Mouse Embryonic Stem Cell Self-renewal, Differentiation and Dedifferentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : LUI LHE

List of Research Outputs

Tanner J.A., LUI L.H.E., AO K.L., SHUM K.T. and Li L., Inorganic polyphosphate triggers interleukin 11 production in osteoblasts, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW01.S1-53.

Researcher : LUI PY

List of Research Outputs

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KEW C., LUI P.Y., Chan C.P., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes simplex virus type 1 Us11 protein inhibits type I interferon production by suppressing PACT mediated activation of RIG-I , The 5th EMBO Meeting 2013, Amsterdam, The Netherlands, September 21-24, 2013.

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W., Mohr I., Jin D. and Kok K.H., Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein, Journal of Virology. 2013, 87: 13141-13149.

LUI P.Y., Kok K.H. and Jin D., The Double-stranded RNA-binding Protein PACT Activates Cytoplasmic Viral Sensor MDA5 by Promoting its Oligomerization , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LUI P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT activates cytoplasmic viral sensor MDA5 by promoting its oligomerization , The American Society for Virology 33rd Annual Meeting, Colorado State University, Fort Collins, Colorado, USA, June 21-25, 2014.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Researcher : LUI WT

List of Research Outputs

LUI W.T., An analysis of the functional significance of the 3’-untranslated region of CHOP/Gadd153 messenger RNA, PhD Thesis, The University of Hong Kong. 2013.

Researcher : Lam VMS

Project Title:	18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Project Title:	HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2002

Project Title:	7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Researcher : Lau TWY

List of Research Outputs

Lau T.W.Y. and Shum D.K.Y., HEPARANASE 1 AND HEPARANASE 2 EXPRESSION IN HIPPOCAMPAL NEURONS, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Lee KS

List of Research Outputs

Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In-Vivo Study of Asporin in Cartilage Tissues. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

Researcher : Lei T

Project Title:	A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis
Investigator(s):	Lei T, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

List of Research Outputs

Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744.

Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87.

Researcher : Leung C

List of Research Outputs

LI Z., Leung C., Zhang M., Sit H.M. and Sham M.H., The role of Sox10 in enteric neural crest cell migration, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Leung HY

List of Research Outputs

LEUNG H.Y. and LEUNG H.Y., A study of membrane-bound neuregulin in mediating fate commitment of Schwann cell-like cells , MPhil Thesis, The University of Hong Kong. 2013.

Researcher : Leung KKH

List of Research Outputs

Cheah K.S.E., HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Rizzoti K. and Lovell-Badge R.H., Sox2 regulates hair type specification and pigmentation, Mouse Molecular Genetics, September 18-21, 2013, Cambridge, UK. 2013.

Researcher : Leung WYG

List of Research Outputs

Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013.

Researcher : Li J

List of Research Outputs

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

Researcher : Li L

List of Research Outputs

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate as a ‘forgotten’ molecule in osteoblasts – from synthesis to function, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

Li L., Lui E.L.H., Buchet R., Mebarek S. and Tanner J.A., Uncovering functions of long-chain polyphosphate in higher eukaryotes – storage and synthesis of polyphosphate in matrix vesicles during mineralization, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Tanner J.A., LUI L.H.E., AO K.L., SHUM K.T. and Li L., Inorganic polyphosphate triggers interleukin 11 production in osteoblasts, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW01.S1-53.

Researcher : Li M

List of Research Outputs

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Expression of Chondroitin Sulfotransferase in Cranial Motor Neurons for Cell Migration in Rat Embryonic Hindbrain, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Varying Expression of Chondroitin Sulfotransferases for Cranial Motor Neuron Migration in Rat Hindbrain Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013 . 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitin sulfotransferase expression pattern for the regulation of cranial motor neuron migration in rat embryonic hindbrain, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 83. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitine sulfotransferase expression pattern in migrating motor neurons of the rat embryonic hindbrain, Soc. Neuroscience Abstract (USA)219.07. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. 9th Pan Pacific Connective Tissue Societies Symposium P68. 2013.

Wong M.K., Li M., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. International Symposium on Physiomics p.79. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : Li T

List of Research Outputs

Li T. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHENG F., Li T., Cheung M.C.H., Syrovatkina V. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips. , FEBS Lett . 2014, 588(6): 859-865.

Researcher : Lin R

Project Title:	Towards a therapeutic peptide that disrupts kinesin-1-NMDAR complex to confer neuroprotection
Investigator(s):	Lin R, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2014

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

LEUNG M.H., KWOK C.T.D., Liu B., Lee C.Y.L. and Yao K.M., Investigating the Protective Role of FOXM1 against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Liu B. and Zhou Z., Depletion of SUV39 ameliorates progeroid phenotypes and extends lifespan in accelerated aging mice, Gordon Research Conference on Aging: The Biology of Aging. Lucca, Italy, 2013.

Liu J., Yin X., Liu B., Zheng H., Zhou G., Gong L., Li M., Li X., Wang Y. and Hu J., HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells, Cell Cycle. 2014, 13: 1237-1247.

Researcher : Liu L

List of Research Outputs

Liu L. and Huang J., Gene Expression Noise in Transcriptional Negative Auto-regulation in Mammalian Cell, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Liu X

List of Research Outputs

KEW C., LUI P.Y., Chan C.P., Liu X., Au S.W.N., Mohr I., Jin D. and Kok K.H., Herpes Simplex Virus Type 1 Us11 Protein Inhibits Type I Interferon Production by Suppressing PACT Induced Activation of RIG-I , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Liu Y

List of Research Outputs

LIU Y., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear sensorineural patterning , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Lovell-Badge RH

List of Research Outputs

Cheah K.S.E., HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Rizzoti K. and Lovell-Badge R.H., Sox2 regulates hair type specification and pigmentation, Mouse Molecular Genetics, September 18-21, 2013, Cambridge, UK. 2013.

Cheng C.C.W., Warren M., Larysa H.P., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse, Proc Natl Acad Sci USA. 2014, 111(7): 2596-2601.

Researcher : Lu X

List of Research Outputs

Researcher : Lui ELH

List of Research Outputs

Li L., Lui E.L.H., Buchet R., Mebarek S. and Tanner J.A., Uncovering functions of long-chain polyphosphate in higher eukaryotes – storage and synthesis of polyphosphate in matrix vesicles during mineralization, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Researcher : Lui PY

List of Research Outputs

Researcher : MA SKY

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Extracellular Matrix in Planarian Regeneration and Stem Cell Maintenance, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

MA S.K.Y., SHEN Y., Ng V.C.W., Yang A., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : MUNG KL

List of Research Outputs

MUNG K.L. and Wong N.S., Defining the Effects of Hypoxia on Glycogen Metabolism in Cancer Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

MUNG K.L. and Wong N.S., The Biochemical Mechanism Of Hypoxia-induced Mobilization Of Glycogen In Cultured Cancer Cell, Metabolism, Diet and Disease 2014: Cancer and metabolism. 2014.

MUNG K.L. and Wong N.S., The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : NGAN WL

List of Research Outputs

NGAN W.L. and Yao K.M., The Interplay between EPS8 and FOXM1 in Carcinogenesis , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013.

Researcher : Ng VCW

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Extracellular Matrix in Planarian Regeneration and Stem Cell Maintenance, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

MA S.K.Y., SHEN Y., Ng V.C.W., Yang A., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., Effect of impaired matrix turnover on differentiation of intervertebral disc cells, 9th Pan Pacific Connective Tissue Symposium, Hong Kong, 24-27th Nov 2013. . 2013.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells, World Forum for Spine Research 2014, Xian, China, 15 - 17th May 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Ni Y

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Ni Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2012
Completion Date:	05/2014

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

Researcher : Osorio Da Silva LA

Project Title:	ISM1 in respiratory system development and homeostasis in the mouse
Investigator(s):	Osorio Da Silva LA, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2014

List of Research Outputs

Osorio Da Silva L.A., Wu X. and Zhou Z., Distinct spatiotemporal expression of ISM1 during mouse and chick development, Cell Cycle. 2014, 13: 1571-1582.

Researcher : QIN J

List of Research Outputs

Guan D., Shao J., Zhao Z., WANG P., Qin J., Deng Y., Boheler K.R., Wang J.J. and Yan B., PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Nucleic Acids Research. 2014.

QIN J., Application of Bioinformatics on Gene Regulation Studies and Regulatory Network Construction with Omics Data, PhD Thesis, The University of Hong Kong. 2013.

QIN J., HU Y.H., XU F. and Wang J.J., Inferring Gene Regulatory Networks from Integrative Omics Data via LASSO-type regularization methods., International Conference on Systems Biology, Huangshan, China, 23-25 August 2013.. 2013.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

QIN J., LI J., WANG P., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high-throughput proteomic and transcriptome data., 21st Annual International Conference on Intelligent Systems for Molecular Biology and 12th European Conference on Computational Biology, Berlin, Germany, 19-23 July 2013.. 2013.

Qin J., Hu Y., XU F., YALAMANCHILI H.K. and Wang J.J., Inferring gene regulatory networks by integrating ChIP-seq/chip and transcriptome data via LASSO-type regularization methods, Methods. 2014.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

Wang Q., He Y., Shen Y., Zhang Q., Chen D., Zuo C., Qin J., Wang H., Wang J.J. and Yu Y., Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4, Journal of Biological Chemistry. 2014.

YALAMANCHILI H.K., Yan B., LI J., Qin J., Zhao Z., Chin F.Y.L. and Wang J.J., DDGni: Dynamic Delay Gene Network Inference from High Temporal Data using Gapped Local Alignment, Bioinformatics. 2013, 30(3): 377-383.

YALAMANCHILI H.K., Yan B., LI J., QIN J., Zhao Z., Chin F.Y.L. and Wang J.J., Inferring Gene Regulatory Network from Variable Delay High Temporal Data. , The 21st Annual International Conference on Intelligent Systems for Molecular Biology / 12th Annual European Conference on Computational Biology (ISMB/ECCB 2013), Berlin, Germany, 21-23 July 2013.. 2013.

Zhang L., Zhu C., Guo Y., Wei F., Lu J., Qin J., Banerjee S., Wang J.J., Shang H. and Verma S.C., Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-J , Journal of Virology. 2014.

Researcher : Qian C

Project Title:	Structural and Functional Analysis of Oncoprotein UHRF1
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010
Completion Date:	10/2013

Project Title:	Structural and Mechanistic Analysis of Human SMARCAL1
Investigator(s):	Qian C, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2011

Project Title:	Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Structural Basis for the interaction of human Timeless with Parp1
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013
Completion Date:	04/2014

Project Title:	Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Structural analysis of Human SLX1-SLX4 Complex in DNA Repair
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

XIE S., Lu Y., Jean J., Sun H., Xia J. and Qian C., Structure of RPA32 Bound to N-terminus of SMARCAL1 Redefines the Binding Interface between RPA32 and its Interacting Proteins , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

XIE S., Mortusewicz O., Ma K., Poon R., Helleday T. and Qian C., Timeless-Parp1 complex facilitates homologous recombination repair, 2014 Hong Kong Inter-University Postgraduate Symposium on Life Science. 2014.

Researcher : Qin J

List of Research Outputs

QIN J., Application of Bioinformatics on Gene Regulation Studies and Regulatory Network Construction with Omics Data, PhD Thesis, The University of Hong Kong. 2013.

Researcher : SHEA GKH

List of Research Outputs

Leung K.H.Y., Tsui Y.P., SHEA G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed Schwann cells from bone marrow stromal cells. (T06-02B), Glia 61 (Suppl): S97. 2013.

Shum D.K.Y., TAI W.Y.E., SHEA G.K.H., Tsui Y.P. and Chan Y.S., An emerging role of Notch signaling in the switch to fate commitment of bone marrow-derived Schwann cells, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association P.32. 2014.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling in in in vitro derivation of Schwann cells from bone marrow stromal cells. (T01-12B) Glia 61 (Suppl): S55, [XI European Meeting on Glial Cells in Health and Disease Berlin, Germany. July 3 - 6, 2013]. 2013.

Researcher : SHEN Y

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Extracellular Matrix in Planarian Regeneration and Stem Cell Maintenance, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

MA S.K.Y., SHEN Y., Ng V.C.W., Yang A., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

SHEN Y. and Chan D., The role of extracellular matrix in planarian regeneration, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : SHI L

List of Research Outputs

SHI L., Development of an Inter-Kingdom Delivery and Expression System for Therapeutic Molecules Against Cancer, PhD Thesis, The University of Hong Kong. 2013.

Researcher : SHUM KT

List of Research Outputs

AO K.L., Wong S., SHUM K.T., Watt R.M. and Tanner J.A., Dissecting the mechanism of how Mycobacterium tuberculosis polyphosphate kinase 2 binds to polyphosphate, EMBO 2013, Amsterdam, The Netherlands . 2013.

Shum K.T., Chan C.S.L. and Tanner J.A., High-affinity Nucleic Acid Aptamers Against Sclerostin Protein, Us Regular Patent. 2013, 85521662 B2.

Tanner J.A., LUI L.H.E., AO K.L., SHUM K.T. and Li L., Inorganic polyphosphate triggers interleukin 11 production in osteoblasts, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW01.S1-53.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	Enteric neural crest cell migration in the developing gut: Molecular and cellular analyses of a Sox10 mouse mutant
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010
Completion Date:	09/2013

Project Title:	The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated Branchio-Oto-Renal syndrome.
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	The roles of Irx3 and Irx5 genes in mammalian inner ear morphogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	The role of Suppressor of fused (Sufu) in mediating hedgehog and beta-catenin signaling in the hindbrain
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013
Completion Date:	12/2013

Project Title:	The requirements of Sox10 and neuropilins in neural crest migration and gangliogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

Project Title:	Craniofacial morphogenesis and tissue regeneration; Analysis of craniofacial defects in Eya1/Six1-associated Branchio-Oto-Renal Syndrome
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014
Completion Date:	04/2014

List of Research Outputs

HU J., Bitter P., Jonas F., Lu X., Li S.H., Sham M.H., Huang W., Lenz P. and Huang W., A Novel Non-Turing Mechanism of Spot Pattern Formation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative characterization of mesencymal cell aggregation. , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Ho J.W.Y., Chan L.K. and Sham M.H., Confronting the challenges of biochemistry teaching and learning in the medical curriculum, Frontiers in Medical and Health Sciences Education,6-7 December 2013, Hong Kong. 2013.

LI Z., Leung C., Zhang M., Sit H.M. and Sham M.H., The role of Sox10 in enteric neural crest cell migration, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

LIU Y., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear sensorineural patterning , 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Sham M.H., ISDSO Award for the 4th International Symposium on Development of the Enteric Nervous System, International Society of Differentiation. 2014.

Sham M.H., Member of the Academic Editorial Board, PLoS ONE. PLoS, 2013.

Sham M.H., Review Editor, Frontiers in Autonomic Neuroscience. Frontiers Editorial Office, 2013.

Sham M.H., The role of Iroquios genes in deafness and inner ear development, School of Basic Medical Sciences, Anhui Medical University, Hefei, China (Plenary Speaker). 2014.

Sham M.H., The role of Iroquois genes in deafness and inner ear development, Peking Union Medical College, Beijing, China.. 2014.

WANG B., Wong Y.M.E., HOR H.H., Hui C.C. and Sham M.H., Gli3 repressor is required to mediate the timing of mammalian cochlear hair cell differentiation., The 47th Annual Meeting of the Japanese Society of Developmental Biologists, Nogoya, Japan, May 28-30, 2014.

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

WANG B., Wong Y.M.E., Liu Y., Hui C.C. and Sham M.H., Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

XU Y., Hor H.H., Hui C.C. and Sham M.H., The role of Suppressed of Fused in neural stem cell proliferation, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, Lucca, Italy, March 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Shen Y

List of Research Outputs

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	10/2007

Project Title:	Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways
Investigator(s):	Shum DKY, Ip MSM, Chan CH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2008

Project Title:	From bone marrow stromal cells to Schwann cells an in vitro route to specification
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010
Completion Date:	03/2014

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY, Chan YS, Tam KW
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	07/2011

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2011

Project Title:	Proheparanase and AMPA receptor trafficking in synaptic plasticity
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	8th International Conference on Proteoglycans (ProteoGlycans 2013); Perineuronal chondroitin sulfates regulate vestibular plasticity during development
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2013
Completion Date:	08/2013

List of Research Outputs

CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014.

CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10^th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013.

CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014.

CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37^th Int’l Congress of International Union of Physiological Sciences PCB120. 2013.

Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cells and neurological disease models, Acta Physiologica Sinica. 2014, 66: 55-66.

Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells, Journal of Neurochemistry, 130 Suppl 1: 26. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry. Kaohsiung. August 23-26, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cells to sensory neurons by combined small molecule inhibitors, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association 33. [HK. June 12-14, 2014] . 2014.

Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Fate commitment of human bone marrow stromal cells to Schwann cells, Proc. 10^th Biennial Conference of Chinese Society for Neuroscience P236. 2013.

Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Mechanism underlying fate commitment of human bone marrow stromal cells to Schwann cells, Proc. International Symposium on Physiomics p.71. [Taipei. Nov. 1-2, 2013]. 2013.

Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013.

Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013.

Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Best Poster Presentation Award, 9th Pan Pacific Connective Tissue Societies Symposium. 2013. 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Certificate of Merit (Oral Presentation of poster), Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK.2014. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Outstanding Abstract Prize (Poster Category) , Ninth International Symposium on Healthy Aging. 2014. 2014.

KWAN P.Y., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates and semaphorin 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium. 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal Maturation of the Vestibular Circuit for Gravity Detection by under the Regulation of Perineuronal Chondroitin Sulfates and Semaphorin 3A , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th FENS Forum of Neuroscience,2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphoring 3A in the developmental maturation of the central vestibular circuitry, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A Associated with Chondroitin Sulfates on Perineuronal Nets Regulates Developmental Maturation of the Central Vestibular Circuitry. , Ninth International Symposium on Healthy Aging. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulfate proteoglycan networks of perineuronal nets regulate developing central vestibular circuitry, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association69. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulphate proteoglycan networks of perineuronal nets regulate the developing central vestibular circuitry, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 69. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin3A, Associated with Perineuronal Nets, Regulates the Development of the Maturation of the Central Vestibular Circuitry, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets and semaphorin 3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th Int’l Symp. on Healthy Aging: 75. 2014.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal chondroitin sulfates and semaphoring 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium P30. [HK. Nov. 24-27, 2013]. 2013.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal maturation of the vestibular circuit for gravity detection is regulated by perineuronal semaphoring 3A and chondroitin sulfates, Proc. International Symposium on Physiomics p.74. 2013.

Kwok L.F. and Shum D.K.Y., CHONDROITINASE ABC-I AND –II LINKED CHITOSAN MICROBEADS INCREASE NEURTIRE LENGTH IN CSPG-ENRICHED ASTROCYTE CULTURE., 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Ninth International Symposium on Healthy Aging. 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 9^th Int’l Symp. on Healthy Aging: Aging with Confidence: 73. 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II linked chitosan microbeads improve axonal regrowth in CSPG-upregulated astrocyte culture, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

LAU W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9^th FENS Forum of Neuroscience777. [Milan, Italy. July 5-9, 2014] . 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Neuronal expression of heparanase 1 and heparanase 2, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 71. 2014.

LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 71, Neuronal expression of heparanase 1 and heparanase 2. 2014.

LEUNG H.Y., TSUI Y.P., Tai E.W.Y., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, European meeting on Glial Cells in Health and Disease. 2013.

Lau T.W.Y. and Shum D.K.Y., HEPARANASE 1 AND HEPARANASE 2 EXPRESSION IN HIPPOCAMPAL NEURONS, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013.

Leung K.H.Y., Tsui Y.P., SHEA G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed Schwann cells from bone marrow stromal cells. (T06-02B), Glia 61 (Suppl): S97. 2013.

Lui C.N.P., Tsui Y.P., Ho A.S.L., Shum D.K.Y., Chan Y.S., Wu C.T., Li H.W., Tsang E.S.C. and Yung K.K.L., Neural Stem Cells Harvested from Live Brains by Antibody-Conjugated Magnetic Nanoparticles, Angewandte Chemie International Edition. 2013, 52: 12298–12302.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, Abstracts of 9th FENS Forum of Neuroscience 1603. 2014.

Ma C.W., Lai C.H., DE NOGUEIRA BOTELHO F.P., Shum D.K.Y. and Chan Y.S., Development of neural correlates of linear motion in the rat vestibular nucleus, Acta Physiologica Sinica. 2014, 66: 37-46.

Ma C.W., Han L., CHAM W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014.

Ma C.W., Chan Y.S. and Shum D.K.Y., Perineuronal chondroitin sulfates regulate vestibular plasticity during development, Proc. Int’l Congress of Proteoglycans p.81. 2013.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic plasticity, Proc. 37^th Int’l Congress of International Union of Physiological Sciences PCB118. 2013.

SHI W., HU H., Shum D.K.Y. and Chan Y.S., Endocannabinoid modulates developmental plasticity of vestibular synapses and the expression of vestibular behavior in rats, Proc. 37^th Int’l Congress of International Union of Physiological Sciences PCB113. [Birmingham, U.K. July 21-26, 2013]. 2013.

SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 76. 2014.

SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 76. 2014.

SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates the efficacy ofof vestibular inhibitory synapses contributing to the expression of gravity-detection behavior in developing rats, Proc. 10^th Biennial Conference of Chinese Society for Neuroscience S15. 2013.

SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats., Soc. Neuroscience Abstract (USA) 129.11. [San Diego. Nov. 9-13, 2013]. 2013.

SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats, Society Neuroscience Abstract (USA), 129.11/C32. 2013.

Shea G.K.H., Shum D.K.Y. and Chan Y.S., Guidance of DRG Neurons on the Fate Determination of Bone Marrow Stromal Cells to Myelinating Glia , In: The University of Hong Kong, 18th Research Postgraduate Symposium. 2013.

Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Targeting Notch signalling to generate bone marrow-derived Schwann cells for transplantation in spinal cord injury, The 33rd Annual Congress of the HKOA. 2013.

Shum D.K.Y., TAI W.Y.E., SHEA G.K.H., Tsui Y.P. and Chan Y.S., An emerging role of Notch signaling in the switch to fate commitment of bone marrow-derived Schwann cells, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association P.32. 2014.

Shum D.K.Y. and Chan Y.S., Emerging role of perineural chondroitin sulfates and semaphorin 3A in maturation of the central vestibular circuitry, Gordon Research Conference on Proteoglycans: Diverse Regulators of Health and Disease[Andover, NH, USA. July 9-11, 2014]. 2014.

Shum D.K.Y., Ma C.W., Lam Y.L., Chan W.C., Han L. and Chan Y.S., Novel role of proheparanase in regulating synaptic function in the central vestibular circuitry, Journal of Neurochemistry, 130 Suppl 1: 20. [11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung. August 23-26, 2014.

Shum D.K.Y., Tsui Y.P., Cai S., TAI W.Y.E. and Chan Y.S., Oligodendrocyte precursors – in vitro derivation from bone marrow stromal cells and use in remyelination therapy, Proc. 10^th Biennial Conference of Chinese Society for Neuroscience 15-01. [Beijing, China. Sept. 20-22, 2013]. ~ Proc. 10~th^~~ Biennial Conference of Chinese Society for Neuroscience/~~15-01, 2013.

Shum D.K.Y., Tsui Y.P., TAI W.Y.E. and Chan Y.S., Towards remyelination therapy with oligodendrocyte precursor and Schwann cells derived from bone marrow stromal cells, Soc. Neuroscience Abstract (USA) 414.09. 2013.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014.

TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Notch Signaling in in vitro derivation of Schwann cells from bone marrow stromal cells, 11th European Meeting on Glial Cells in Health and Disease. 2013.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling in in in vitro derivation of Schwann cells from bone marrow stromal cells. (T01-12B) Glia 61 (Suppl): S55, [XI European Meeting on Glial Cells in Health and Disease Berlin, Germany. July 3 - 6, 2013]. 2013.

TUNG W.T. and Shum D.K.Y., Chitosan Nanofiber Composed Nerve Conduit for Directing Axonal Growth, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Oriented Schwann Cells Culture on Aligned Chitosan Nanofibers for Axonal Growth Guidance, 11th International Conference on Materials Chemistry: P056. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Overcoming the chondroitin sulphate barrier in injured nerve: the efficacy of chondroitinase ABC treatment and the potency of disaccharide products, Ninth International Symposium on Healthy Aging. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. 10^th Biennial Conference of Chinese Society for Neuroscience P184. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. Int’l Conference on Proteoglycans p. 39. [ProteoGlycans 2013 Frankfurt/ Main, Germany. August 25-29, 2013]. 2013.

Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursor cells from bone marrow stromal cells for remyelination therapy, Proc. 37^th Int’l Congress of International Union of Physiological Sciences PCB116. 2013.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, 12th Annual Meeting of the International Society for Stem Cell Research. 2014.

Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, Abstracts of 12^th Annual Meeting of International Society for Stem Cell Research: 470. [Vancouver, Canada. June 18-21, 2014]. 2014.

Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., From the marrow to two glial lineages—Derivation of oligodendrocyte precursors and Schwann cells from bone marrow stromal cells for remyelination therapy, Cold Spring Harbor Asia/International Society for Stem Cell Research (CSHA/ISSCR) Joint Conference on Stem Cells in Science and Medicine. 2013.

Tsui Y.P., Li R., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: Derivation of oligodendrocyte precursors from adult bone marrow stromal cells. (T09-11B) , Glia 61 (Suppl): S151. 2013.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 80. 2014.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursors from adult bone marrow stromal cells, The 11^th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers seeded with Schwann cells for construction of a nerve guidance channel, Ninth International Symposium on Healthy Aging. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 81. 2014.

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Expression of Chondroitin Sulfotransferase in Cranial Motor Neurons for Cell Migration in Rat Embryonic Hindbrain, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Varying Expression of Chondroitin Sulfotransferases for Cranial Motor Neuron Migration in Rat Hindbrain Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013 . 2013.

WU L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Role of Heparanase in Controlling Airway Syndecan-1 Shedding and Airway Inflammation , 2013.

WU L.K., Chan C.H., Mak J.C.W., Tan C., Lam C.L.D., Ip M.S.M. and Shum D.K.Y., Using Polyanionic Heparin Mimetics for the treatment of COPD, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitin sulfotransferase expression pattern for the regulation of cranial motor neuron migration in rat embryonic hindbrain, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 83. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitine sulfotransferase expression pattern in migrating motor neurons of the rat embryonic hindbrain, Soc. Neuroscience Abstract (USA)219.07. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. 9th Pan Pacific Connective Tissue Societies Symposium P68. 2013.

Wong M.K., Li M., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. International Symposium on Physiomics p.79. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : Shum KT

List of Research Outputs

Shum K.T., Chan C.S.L. and Tanner J.A., High-affinity Nucleic Acid Aptamers Against Sclerostin Protein, Us Regular Patent. 2013, 85521662 B2.

Researcher : Sit HM

List of Research Outputs

LI Z., Leung C., Zhang M., Sit H.M. and Sham M.H., The role of Sox10 in enteric neural crest cell migration, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Siu KL

List of Research Outputs

KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1, Cell & Bioscience . 2014, 4: 3.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain, Cellular & Molecular Immunology. 2014, 11: 141-149.

WANG P., Siu K.L., Yang W., Zhang Y. and Kok K.H., Roles of a Novel Splice Variant of Human IFI16 in Innate Immune Response , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., Roles of a novel splice variant of human IFI16 in innate immune response, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Siu YT

List of Research Outputs

Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47.

Researcher : Smith DK

Project Title:	Patterns in proteins with unusual flexibility profiles
Investigator(s):	Smith DK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	08/2002

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	In silico identification of genetic variations that affect resistance to influenza A virus infection
Investigator(s):	Song Y, To KKW, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2011

Project Title:	Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice
Investigator(s):	Song Y, Cheah KSE, Sham PC
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Analysis of exome sequencing of APOEε4 negative Alzheimer’s disease case/control subjects in southern Chinese
Investigator(s):	Song Y, Sham PC, Chu LW
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	04/2014

Project Title:	Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese
Investigator(s):	Song Y, Sham PC, Fan Y
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	The role of hnrnpa1 in human congenital heart defects
Investigator(s):	Song Y, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Repurposing the approved drugs for prevention and treatment of Alzheimer’s disease in transgenic mouse models
Investigator(s):	Song Y, Chu LW
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014

List of Research Outputs

Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes affecting host resistance to influenza by network approaches, BMC Genomics . 2013, 14(1): 816.

Bao S., Zhou X., Zhang L., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches.BMC genomics, BMC genomics. 2013.

Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.W., Wang B.B., Wang L., Zhang X.G. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches, BMC Genomics. 2013, 4: 1816 (16 pages).

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., AR Hodgson Award - Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study, 33rd Annual Congress of The Hong Kong Orthopaedic Association. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H.I.D.E.K.I., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association Study (Awards session AR Hodgson Winner), 33rd Hong Kong Orthopaedic Association Annual Congress. 2013.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Prediction of Lumbar Spinal Stenosis in Chinese: Findings from a Genome-wide Association StudyGenome-wide association study of Spinal Stenosis in Southern Chinese: The first of its kind, 33rd Hong Kong Orthopaedic Association Annual Congress. Hong Kong, 2013.

LI T., Yan C.H., Xu A., Song Y. and Chiu P.K.Y., Assessment Of Systemic Inflammation In Oa Patients By Testing Fatty-acid-binding Protein 4 And Adiponectin In Plasma, The 33rd Hong Kong Orthopaedic Association Annual Congress. 2013, 21.

LI T., Yan C.H., Xu A., Song Y. and Chiu P.K.Y., Comparison Of Fatty-acid-binding Protein 4 And Adiponectin Levels In Infrapatellar Fat Pad And Subcutaneous Adipose Tissue, Synovial Fluid And Plasma In Subjects With Knee Osteoarthritis, 33rd Hong Kong Orthopaedic Association Annual Congress. 2013, 21.

Lee K.S., Lam T.K., Song Y., Cheah K.S.E., Cheung K.M.C. and Chan D., In-Vivo Study of Asporin in Cartilage Tissues. , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

Londono D., Kou I., Johnson T.A., Sharma S., Ogura Y., Tsunoda T., Takahashi A., Matsumoto M., Herring J.A., Lam T.P., Wang X., Tam E.M., Song Y., Fan Y., Chan D., Cheah K.S.E., Qiu X., Jiang H., Huang D., Japanese Scoliosis Clinical Research Group ,., TSRHC IS Clinical Group ,., the International Consortium for Scoliosis Genetics ,., Su P., Sham P.C., Cheung K.M.C., Luk K.D.K., Gordon D., Qiu Y. and Cheng J., Tang N., Ikegawa S., Wise C.A., A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. , J Med Genet. . 2014, 51: 401-406.

Mak H.K.F., Qian W., Ng K.S., Chan Q., Song Y., Chu L.W. and Yau K.K., Combination of MRI hippocampal volumetry and arterial spin labeling MR perfusion at 3-Tesla improves the efficacy in discriminating Alzheimer's disease from cognitively normal elderly adults, In: George Perry, Journal of Alzheimer's Disease. IOS Press, 2014, 41: 749-758.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243.

Yee F.Y.A., Song Y., Chan D. and Cheung K.M.C., Understanding the Basis of Genetic Studies: Adolescent Idiopathic Scoliosis as an Example, Spine Deformity. 2014, 2: 1-9.

Researcher : Sy MH

Project Title:	Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0
Investigator(s):	Sy MH, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Sy M.H., Guo Y., Feng W. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Sze KL

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

Researcher : Szeto YY

Project Title:	Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear
Investigator(s):	Szeto YY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Researcher : TAN Z

List of Research Outputs

TAN Z., Molecular Analyses of Chondrocyte Differentiation and Adaptation to ER Stress, PhD Thesis, The University of Hong Kong. 2013.

WEN S., Tan Z., Tsang K.Y., Tsang S.W. and Cheah K.S.E., The Role of Irx3/5 in Regulating Lineage Progression of Hypertrophic Chondrocyte to Osteoblasts , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : TSUI MG

List of Research Outputs

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Modulator of Hedegehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Negative Modulator of Hedgehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 14, 2014.

Researcher : TSUI YP

List of Research Outputs

LEUNG H.Y., TSUI Y.P., Tai E.W.Y., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, European meeting on Glial Cells in Health and Disease. 2013.

TSUI Y.P., Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells , MPhil Thesis, The University of Hong Kong. 2013.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursors from adult bone marrow stromal cells, The 11^th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013.

Researcher : TUCKER WO

List of Research Outputs

TUCKER W.O., Towards Specific DNA Aptamers Which Bind and Inhibit WWP1 Ubiquitin Ligase in the Osteoblast, PhD Thesis, The University of Hong Kong. 2013.

Tanner J.A. and TUCKER W.O., Discovery and application of DNA aptamers which specifically bind and inhibit WWP1 ubiquitin ligase in the osteoblast, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW03.S15-18, 271.

Researcher : TUNG WT

List of Research Outputs

TUNG W.T. and Shum D.K.Y., Chitosan Nanofiber Composed Nerve Conduit for Directing Axonal Growth, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Oriented Schwann Cells Culture on Aligned Chitosan Nanofibers for Axonal Growth Guidance, 11th International Conference on Materials Chemistry: P056. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers seeded with Schwann cells for construction of a nerve guidance channel, Ninth International Symposium on Healthy Aging. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 81. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Kwok L.F., Use of Schwann cell-seeded nanofiber as nerve conduit, 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies. 2014.

Researcher : Tai CP

Project Title:	Conservation of chordate SOXE protein function in chondrogenesis
Investigator(s):	Tai CP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012

Researcher : Tam JWO

Project Title:	14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis
Investigator(s):	Tam JWO
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Researcher : Tam KW

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Ninth International Symposium on Healthy Aging. 2014.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II linked chitosan microbeads improve axonal regrowth in CSPG-upregulated astrocyte culture, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Oriented Schwann Cells Culture on Aligned Chitosan Nanofibers for Axonal Growth Guidance, 11th International Conference on Materials Chemistry: P056. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Overcoming the chondroitin sulphate barrier in injured nerve: the efficacy of chondroitinase ABC treatment and the potency of disaccharide products, Ninth International Symposium on Healthy Aging. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers seeded with Schwann cells for construction of a nerve guidance channel, Ninth International Symposium on Healthy Aging. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Kwok L.F., Use of Schwann cell-seeded nanofiber as nerve conduit, 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies. 2014.

Researcher : Tam V

Project Title:	A comparison of nucleus pulposus cell phenotypic changes after culture on a decellularised disc scaffold
Investigator(s):	Tam V, Cheung KMC
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	08/2013

List of Research Outputs

Chan W.C.W., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., A Systematic and Simple Scoring System for Histological Analysis of the Mouse Intervertebral Disc during Natural Ageing, Degeneration, and Regeneration, World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China May 15-17, 2014.

Chan W.C.W., Au Y.K., Tam V., Cheah K.S.E. and Chan D., Coming together is a beginning: The making of an intervertebral disc, Birth Defects Research Part C: Embryo Today: Reviews. 2014, 102: 83-100.

Yee F.Y.A., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., Analysis Of The Static Protein Profile Of Degenerated Ivd Indicate Increased Fibrosis-related Proteins, World Forum For Spine Research, 2014 (Xian). 2014.

Yee F.Y.A., Tam V., Cheung K.M.C. and Chan D., Proteomics Analysis Of The Human Intervertebral Disc Reveals Potential Fibrotic Events In Degeneration , 9th Pan Pacific Connective Tissue Societies Symposium. 2013.

ZHANG Y., Xiong C., Chan W.C.W., Tam V., Sakai D. and Chan D., Are There Protective Genes for Disc Degeneration? , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

Researcher : Tan Z

List of Research Outputs

TAN Z., Molecular Analyses of Chondrocyte Differentiation and Adaptation to ER Stress, PhD Thesis, The University of Hong Kong. 2013.

Researcher : Tang HC

List of Research Outputs

Cheah K.S.E., Yang L., Tsang K.Y., Tang H.C., Tsang S.W., Yang Y.Z. and Chan D., Lineage extension chondrocytes and the ontogeny of bone cells, The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan, May 27-Jun 1, 2014.. 2014.

Researcher : Tang HMV

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Tang H.M.V., GAO W., Chan C.P., Kok K.H. and Jin D., CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication, Cancer & Metabolism. 2014, 2: P31.

YUEN K.S., Tang H.M.V., Kok K.H. and Jin D., Roles of Epstein-Barr Virus-encoded miR-BART microRNAs in Nasopharyngeal Epithelial Tumorigenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Tang VHM

List of Research Outputs

Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47.

Chan C.P., Kok K.H., Tang V.H.M., Wong C.M. and Jin D., Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013, 1833: 2165-2175.

KONG K.Y., Tang V.H.M., Pan K., HUANG Z., LEE T.H.J., Hinnebusch A., Jin D. and Wong C.M., Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing, Nucleic Acids Research. Oxford Journals, 2014, 42: 643-660.

Lo I.F.M., Leung K.C., Luk H.M., Tang V.H.M., Gao W., Wong W.L., Tang L.Y.F., Chu W.Y., Kan S.Y.A., Tang M.H.Y., Lam S.T.S., Yang W., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Identifying genetic mutations in patients with RASopathies using a new generation sequencing diagnostic pipeline in Hong Kong, Annual Scientific Meeting, Hong Kong College of Paediatricians, HK, 7 December 2013. 19.

Tang V.H.M., 14th SCBA International Symposium Best Poster Award, Society of Chinese Bioscientists in America. 2013.

Tang V.H.M., 2013 SCBA Travel fellowship, Society of Chinese Bioscientists in America. 2013.

Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013.

Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013.

Researcher : Tanner J.A.

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012
Completion Date:	06/2014

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	10/2014

Project Title:	Aptamers in Medicine (Oct 4-5) and Oligonucleotide Therapeutics Society Meeting (Oct 6-8); Loops, hairpins and flipped bases: a DNA aptamer that discriminates Plasmodium lactate dehydrogenase from the blind watchmaker/Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2013
Completion Date:	10/2013

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012
Completion Date:	06/2014

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	10/2014

Project Title:	Aptamers in Medicine (Oct 4-5) and Oligonucleotide Therapeutics Society Meeting (Oct 6-8); Loops, hairpins and flipped bases: a DNA aptamer that discriminates Plasmodium lactate dehydrogenase from the blind watchmaker/Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2013
Completion Date:	10/2013

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

ALBANO D.R.B., CHEUNG Y.W., Tanner J.A. and Fung Y.S., Study of aptamer selection methodologies for developing piezoelectric quartz crystal biosensors to detect microalbuminaria, malaria and SARS biomarkers, 29th Philippine Chemistry Congress, Mandaluyong City, Philippines . 2014.

AO K.L., Wong S., SHUM K.T., Watt R.M. and Tanner J.A., Dissecting the mechanism of how Mycobacterium tuberculosis polyphosphate kinase 2 binds to polyphosphate, EMBO 2013, Amsterdam, The Netherlands . 2013.

Albano D.R.B., Tanner J.A. and Fung Y.S., Determination of Protein Biomarkers By Microflow Injection Aptamer-coated Piezoelectric Quartz Crystal Biosensor, 14th International Symposium on Electroanalytical Chemistry (14th ISEAC). Changchun, China, 2013, 21-22.

CHEUNG Y.W., KWOK H.C.J., LAW W.L., Watt R.M., Kotaka M. and Tanner J.A., Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase, Proceedings of the National Academy of Sciences USA. 2013, 110(40): 15967-15972.

Chan C.C.Y., Chan D., Tanner J.A., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of sedlin component of the TRAPP complex in mouse embryonic development, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

DIRKZWAGER R.M. and Tanner J.A., A Novel Aptamer-Based Enzymatic Assay for the Diagnosis of Malaria, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium. 2014.

DIRKZWAGER R.M., Cheung Y.W. and Tanner J.A., Best Poster Prize - A novel aptamer-based enzymatic assay for the diagnosis of malaria, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Best Poster Prize - Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., Exploiting aptamer binding properties as a novel diagnostic technology for malaria, HKU 18th Research Postgraduate Symposium. 2013.

Gao W., You M., Tanner J.A., Leung W.K. and Watt R.M., Development of DNA aptamers against Treponema denticola, Journal of Dental Research. 2014, 93 (Spec Iss B): 388.

KHONG M.L. and Tanner J.A., Inorganic Polyphosphate as a Forgotten Molecule in Osteoblasts - From Synthesis to Function, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate as a ‘forgotten’ molecule in osteoblasts – from synthesis to function, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

KINGHORN A.B. and Tanner J.A., Aptamer library resampling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

KINGHORN A.B. and Tanner J.A., Aptamer library resampling, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

LIANG S. and Tanner J.A., Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

LIANG S., Dhillo W., Cass T. and Tanner J.A., Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment, Hong Kong Inter-University Research Postgraduate Symposium . 2014.

Li L., Lui E.L.H., Buchet R., Mebarek S. and Tanner J.A., Uncovering functions of long-chain polyphosphate in higher eukaryotes – storage and synthesis of polyphosphate in matrix vesicles during mineralization, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

Shum K.T., Chan C.S.L. and Tanner J.A., High-affinity Nucleic Acid Aptamers Against Sclerostin Protein, Us Regular Patent. 2013, 85521662 B2.

Tanner J.A., A discriminatory DNA aptamer for malaria diagnostics from the blind watchmaker, Croucher Advanced Study Institute on Chemical Biology, Hong Kong . 2013.

Tanner J.A., DNA aptamer-mediated recognition of malaria diagnostic target Plasmodium lactate dehydrogenase – structure, discrimination and application, 2014 Joint International Symposium: Biomedical Research Across the Continents, Tsinghua University, Beijing, China. 2014.

Tanner J.A., DNA aptamers as new therapeutic agents against sclerostin, ADAMTS-5 and WWP1 ubiquitin ligase, Hong Kong-Australia Symposium on Orthopaedic Related Research and Clinical Applications. Hong Kong . 2014.

Tanner J.A., DNA aptamers for diagnostic applications – structural insight into discriminatory recognition of malaria diagnostic targets, 6th China Medicinal Biotech Forum, Shenzhen, China . 2013.

Tanner J.A. and TUCKER W.O., Discovery and application of DNA aptamers which specifically bind and inhibit WWP1 ubiquitin ligase in the osteoblast, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW03.S15-18, 271.

Tanner J.A., LUI L.H.E., AO K.L., SHUM K.T. and Li L., Inorganic polyphosphate triggers interleukin 11 production in osteoblasts, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia . 2013, FEBS J: 280 (Suppl.1) SW01.S1-53.

Tanner J.A., Cheung Y.W., Watt R.M. and Kotaka M., Loops, hairpins and flipped bases: a DNA aptamer that discriminates Plasmodium lactate dehydrogenase from the blind watchmaker, 9th Annual Meeting of the Oligonucleotide Therapeutics Society, Naples, Italy. 2013.

Tanner J.A., CHEUNG Y.W., DIRKZWAGER R.M., KINGHORN A.B. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis – discovery, characterization, structure and application, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SW01.W5-30, 87.

Tanner J.A., Bevan S.J., Cheng L.Y.L., Chan W.L. and Wong B.C.W., Promoting deep learning in biochemistry by diversifying assessment strategies – experience at the University of Hong Kong, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SA04-8, 626.

Tanner J.A., Cheung Y.W., KWOK H.C.J., LAW W.L., ALBANO D.R.B., Fung Y.S., Watt R.M. and Kotaka M., Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer, Aptamers in Medicine and Perspectives, Naples, Italy . 2013.

YU Y. and Tanner J.A., A novel aptamer-mediated approach for degenerative disc disease therapy, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

YU Y., Chan D., Cheah K.S.E. and Tanner J.A., DNA aptamers can discriminate between closely related aggrecanase drug targets for degenerative disc disease therapy, 50th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery, Rouen, France. 2014.

YU Y. and Tanner J.A., Discriminatory Targeting of ADAMTS Aggrecanases for High-specificity Therapeutics Development for Degenerative Disc Disease , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

YU Y. and Tanner J.A., Discriminatory targeting of ADAMTS aggrecanases for high-specificity therapeutics development for degenerative disc disease, HKU 18th Research Postgraduate Symposium, Hong Kong . 2013.

You M., GAO W., Tanner J.A., Leung W.K. and Watt R.M., The selection of DNA aptamers against an oral treponeme cell surface protein, Annual Scientific Meeting, Faculty of Dentistry, University of Hong Kong. 2013.

Researcher : Tsang KY

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates the Lineage Progression of Hypertrophic Chondrocytes, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Cheah K.S.E., Yang L., Tsang K.Y., Tang H.C., Tsang S.W., Yang Y.Z. and Chan D., Lineage extension chondrocytes and the ontogeny of bone cells, The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan, May 27-Jun 1, 2014.. 2014.

Tsang K.Y., Tsang S.W., Chan D. and Cheah K.S.E., The chondrocytic journey in endochondral bone growth and skeletal dysplasia, Birth Defects Res C Embryo Today. 2014, 102(1): 52-73.

WEN S., Tan Z., Tsang K.Y., Tsang S.W. and Cheah K.S.E., The Role of Irx3/5 in Regulating Lineage Progression of Hypertrophic Chondrocyte to Osteoblasts , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Tsang SL

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, Lucca, Italy, March 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Tsang SW

Project Title:	Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo
Investigator(s):	Tsang SW, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates the Lineage Progression of Hypertrophic Chondrocytes, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Cheah K.S.E., Yang L., Tsang K.Y., Tang H.C., Tsang S.W., Yang Y.Z. and Chan D., Lineage extension chondrocytes and the ontogeny of bone cells, The 47th Annual Meeting of the Japanese Society of Developmental Biologists Nagoya, Japan, May 27-Jun 1, 2014.. 2014.

Tsang K.Y., Tsang S.W., Chan D. and Cheah K.S.E., The chondrocytic journey in endochondral bone growth and skeletal dysplasia, Birth Defects Res C Embryo Today. 2014, 102(1): 52-73.

WEN S., Tan Z., Tsang K.Y., Tsang S.W. and Cheah K.S.E., The Role of Irx3/5 in Regulating Lineage Progression of Hypertrophic Chondrocyte to Osteoblasts , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Tsui YP

Project Title:	International Society for Stem Cell Research 12th Annual Meeting; DIVERGENT ROUTES FOR DERIVATION OF ALTERNATIVE GLIAL CELL FATE FROM BONE MARROW STROMAL CELLS OF ADULT RATS FOR REMYELINATION
Investigator(s):	Tsui YP
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2014

List of Research Outputs

TSUI Y.P., Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells , MPhil Thesis, The University of Hong Kong. 2013.

Researcher : Tung WT

List of Research Outputs

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Kwok L.F., Use of Schwann cell-seeded nanofiber as nerve conduit, 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies. 2014.

Researcher : WANG B

List of Research Outputs

WANG B., Wong Y.M.E., HOR H.H., Hui C.C. and Sham M.H., Gli3 repressor is required to mediate the timing of mammalian cochlear hair cell differentiation., The 47th Annual Meeting of the Japanese Society of Developmental Biologists, Nogoya, Japan, May 28-30, 2014.

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

WANG B., Wong Y.M.E., Liu Y., Hui C.C. and Sham M.H., Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : WANG M

List of Research Outputs

WANG M., The role of fibronectin and atypical protein kinase C iota in the development of notochord and chondrocytes, MPhil Thesis, The University of Hong Kong. 2013.

Researcher : WANG P

List of Research Outputs

Cheng T., XIA W., WANG P., HUANG F., Wang J.J. and Sun H., Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence, Metallomics. 2013, 5(10): 1423-1429.

GAO W., Tang H.M.V., Chan C.P., WANG P., Kok K.H. and Jin D., Regulation of Ubiquitination and Degradation of CRTC1 Transcriptional Coactivator by Salt-inducible Kinase SIK1 , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Guan D., Shao J., Deng Y., WANG P., Zhao Z., Liang Y., Wang J.J. and Yan B., CMGRN: a web server for constructing multi-level gene regulatory networks using ChIP-seq and gene expression data, Bioinformatics. 2014.

Guan D., Shao J., Zhao Z., WANG P., Qin J., Deng Y., Boheler K.R., Wang J.J. and Yan B., PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Nucleic Acids Research. 2014.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

QIN J., LI J., WANG P., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high-throughput proteomic and transcriptome data., 21st Annual International Conference on Intelligent Systems for Molecular Biology and 12th European Conference on Computational Biology, Berlin, Germany, 19-23 July 2013.. 2013.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

WANG P., Siu K.L., Yang W., Zhang Y. and Kok K.H., Roles of a Novel Splice Variant of Human IFI16 in Innate Immune Response , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., Roles of a novel splice variant of human IFI16 in innate immune response, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

WANG W., XU F., WANG P., LI J., Sham P.C. and Wang J.J., Assessment of Aligner and SNP Caller for Next Generation Sequencing and a Fast and Accurate SNP Detection Method., The 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2013) and the 12th Annual European Conference on Computational Biology (ECCB), Berlin, Germany,19-23 July, 2013.

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

Researcher : WANG P

List of Research Outputs

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

Researcher : WANG W

List of Research Outputs

WANG W., XU F., WANG P., LI J., Sham P.C. and Wang J.J., Assessment of Aligner and SNP Caller for Next Generation Sequencing and a Fast and Accurate SNP Detection Method., The 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2013) and the 12th Annual European Conference on Computational Biology (ECCB), Berlin, Germany,19-23 July, 2013.

WANG W., XU F. and Wang J.J., Assessment of Mapping and SNP-Detection Algorithms for Next-Generation Sequencing Data in Cancer Genomics, In: Wei Wu, Hani Choudhry, Next Generation Sequencing in Cancer Research. New York, NY, Springer New York, 2013, 301-317.

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

Researcher : WANG X

List of Research Outputs

WANG X., Molecular and Cellular Consequences of Indian Hedgehog Muttions Causing Brachydactyli, PhD Thesis, The University of Hong Kong. 2013.

Researcher : WANG Y

List of Research Outputs

LI J., Wang Y., Xia Z.Y., Sham P.C. and Wang J.J., GWAS3D: Detecting Human Regulatory Variants by Integrative Analysis of Genome-wide Associations and Chromosome States , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, Nucleic Acids Res. 2013, 41(W1): W150-W158.

LI J., WANG Y., Zhang M.Q. and Wang J.J., Systematic analysis of the role of transcription regulators in distal interactions., The Gordon Research Conference (GRC) on "Post-translational Modification Networks – Phospho-signaling", The Hong Kong University of Science & Technology, Hong Kong, 28 Aug 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., The best poster presentation award, The 5th International Conference on Computational and Systems Biology, SUSTC, Shenzhen, Nov15, 2013 . 2013.

LI J., WANG Y. and Wang J.J., dbPSHP: a database of recent positive selection across human population, The 5th Annual International Conference on Computational and Systems Biology (ICCSB2013), Shenzhen, China, 14-16 November 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

WANG Y., LI J. and Wang J.J., Analysis of long-range chromatin interaction and how transcription factors are involved to regulate gene expression, Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor Laboratory, New York, US, 18-22 March 2014.

WANG Y., Induction of cells with osteo-chondrogenic potential by transcription factor-mediated reprogramming process , PhD Thesis, The University of Hong Kong. 2013.

Wang Y. and Wang J.J., Analysis of long-range chromatin interaction and how transcription factors are involved to regulate gene expression, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : WANG Y

List of Research Outputs

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

WANG Y., Induction of cells with osteo-chondrogenic potential by transcription factor-mediated reprogramming process , PhD Thesis, The University of Hong Kong. 2013.

Researcher : WEN S

List of Research Outputs

WEN S., Tan Z., Tsang K.Y., Tsang S.W. and Cheah K.S.E., The Role of Irx3/5 in Regulating Lineage Progression of Hypertrophic Chondrocyte to Osteoblasts , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : WONG HLX

List of Research Outputs

WONG H.L.X., The Functional Crosstalk between MT1-MMP and ADAMs in Craniofacial & Vascular, PhD Thesis, The University of Hong Kong. 2013.

Researcher : WONG MK

List of Research Outputs

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Expression of Chondroitin Sulfotransferase in Cranial Motor Neurons for Cell Migration in Rat Embryonic Hindbrain, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Varying Expression of Chondroitin Sulfotransferases for Cranial Motor Neuron Migration in Rat Hindbrain Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013 . 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitin sulfotransferase expression pattern for the regulation of cranial motor neuron migration in rat embryonic hindbrain, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 83. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitine sulfotransferase expression pattern in migrating motor neurons of the rat embryonic hindbrain, Soc. Neuroscience Abstract (USA)219.07. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. 9th Pan Pacific Connective Tissue Societies Symposium P68. 2013.

Wong M.K., Li M., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. International Symposium on Physiomics p.79. 2013.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : WONG PY

List of Research Outputs

WONG P.Y. and Wong N.S., Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect., 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : WU LK

List of Research Outputs

WU L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Role of Heparanase in Controlling Airway Syndecan-1 Shedding and Airway Inflammation , 2013.

WU L.K., Chan C.H., Mak J.C.W., Tan C., Lam C.L.D., Ip M.S.M. and Shum D.K.Y., Using Polyanionic Heparin Mimetics for the treatment of COPD, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : Wang JJ

Project Title:	A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
Investigator(s):	Wang JJ, Tsao GSW
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Understanding the co-evolutionary relationship between transcription factors and their DNA binding sites for bHLH family in eukaryotes
Investigator(s):	Wang JJ, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Outstanding Young Researcher Award 2011-12
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2013

Project Title:	A computational framework to infer regulatory modules from integrative analysis of ChIP-seq and transcriptome data
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Design of versatile super promoters for highly efficient mammalian gene expression
Investigator(s):	Wang JJ, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

Project Title:	ISMB/ECCB 2013; Genetic variants in the next generation: detection, reprioritizing and function annotation
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013

Project Title:	A computational algorithm to identify regulators for regulatory genetic variants in cancer genomics
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014

List of Research Outputs

Cheng T., XIA W., WANG P., HUANG F., Wang J.J. and Sun H., Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence, Metallomics. 2013, 5(10): 1423-1429.

Guan D., Shao J., Deng Y., WANG P., Zhao Z., Liang Y., Wang J.J. and Yan B., CMGRN: a web server for constructing multi-level gene regulatory networks using ChIP-seq and gene expression data, Bioinformatics. 2014.

Guan D., Shao J., Zhao Z., WANG P., Qin J., Deng Y., Boheler K.R., Wang J.J. and Yan B., PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Nucleic Acids Research. 2014.

LI H., LIU Z., Wang J.J., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to Myocardial Ischemia Reperfusion Injury at Early Stage of Type 1 Diabetes in Rats, Cardiovascular Diabetology. BioMed Central, 2013, 12: 133.

LI J., Yan B., Sham P.C. and Wang J.J., Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression, Briefings in Bioinformatics. 2014.

LI J., Wang Y., Xia Z.Y., Sham P.C. and Wang J.J., GWAS3D: Detecting Human Regulatory Variants by Integrative Analysis of Genome-wide Associations and Chromosome States , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, Nucleic Acids Res. 2013, 41(W1): W150-W158.

LI J., WANG Y., Zhang M.Q. and Wang J.J., Systematic analysis of the role of transcription regulators in distal interactions., The Gordon Research Conference (GRC) on "Post-translational Modification Networks – Phospho-signaling", The Hong Kong University of Science & Technology, Hong Kong, 28 Aug 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., The best poster presentation award, The 5th International Conference on Computational and Systems Biology, SUSTC, Shenzhen, Nov15, 2013 . 2013.

LI J., WANG Y. and Wang J.J., dbPSHP: a database of recent positive selection across human population, The 5th Annual International Conference on Computational and Systems Biology (ICCSB2013), Shenzhen, China, 14-16 November 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

Lei S., LI H., Xu J., LIU Y., Gao X., Wang J.J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced Protein Kinase C beta2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling, Diabetes. 2013, 62(7): 2318-28.

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

QIN J., HU Y.H., XU F. and Wang J.J., Inferring Gene Regulatory Networks from Integrative Omics Data via LASSO-type regularization methods., International Conference on Systems Biology, Huangshan, China, 23-25 August 2013.. 2013.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

QIN J., LI J., WANG P., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high-throughput proteomic and transcriptome data., 21st Annual International Conference on Intelligent Systems for Molecular Biology and 12th European Conference on Computational Biology, Berlin, Germany, 19-23 July 2013.. 2013.

Qin J., Hu Y., XU F., YALAMANCHILI H.K. and Wang J.J., Inferring gene regulatory networks by integrating ChIP-seq/chip and transcriptome data via LASSO-type regularization methods, Methods. 2014.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

WANG W., XU F., WANG P., LI J., Sham P.C. and Wang J.J., Assessment of Aligner and SNP Caller for Next Generation Sequencing and a Fast and Accurate SNP Detection Method., The 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2013) and the 12th Annual European Conference on Computational Biology (ECCB), Berlin, Germany,19-23 July, 2013.

WANG W., XU F. and Wang J.J., Assessment of Mapping and SNP-Detection Algorithms for Next-Generation Sequencing Data in Cancer Genomics, In: Wei Wu, Hani Choudhry, Next Generation Sequencing in Cancer Research. New York, NY, Springer New York, 2013, 301-317.

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

WANG Y., LI J. and Wang J.J., Analysis of long-range chromatin interaction and how transcription factors are involved to regulate gene expression, Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor Laboratory, New York, US, 18-22 March 2014.

Wang J.J., Academic Editor, 2013-present, PLoS ONE. 2013.

Wang J.J., Chair for highlight session, ISB 2013-IEEE International Conference on Systems Biology, 22-25 August, 2013, Huangshan, Anhui, China . 2013.

Wang J.J., Editor, 2013-present, Journal of Metabolomics and Systems Biology. 2013.

Wang J.J., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, ISB 2013, Huangshan, Anhui, China, 23 August, 2013. 2013.

Wang J.J., Genetic variations in the next generation: detection, prioritizing and functional annotation, ISMB/ECCB 2013, Berlin, Germany, 23 July, 2013. 2013.

Wang J.J., Integrative analysis of OMICs big data for network inference, Youth forum for interdisciplinary research in math, computer science and life sciences (http://omicslab.genetics.ac.cn/youthforum/ ), Beijing, China, May 24-25, 2014. 2014.

Wang J.J., Integrative analysis of OMICs data for functional genomics, Nephrology update West lake forum (http://www.westlakeforum.net/), Hangzhou, China, March 27-29, 2014. 2014.

Wang J.J., PC Member, BIBM 2013- IEEE International Conference on Bioinformatics & Biomedicine 2013, 18-22 Dec., 2013, Shanghai, China . 2013.

Wang J.J., PC member , ISB 2013-IEEE International Conference on Systems Biology, 22-25 August, 2013, Huangshan, Anhui, China . 2013.

Wang P., Lai W.F., Li J., Xu F., Yalamanchili H.K., Lovell-Badge R. and Wang J.J., Inference of Gene-Phenotype Associations via Protein-Protein Interaction and Orthology, PLoS One. 2013, 8(10): e77478.

Wang Q., He Y., Shen Y., Zhang Q., Chen D., Zuo C., Qin J., Wang H., Wang J.J. and Yu Y., Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4, Journal of Biological Chemistry. 2014.

Wang Y. and Wang J.J., Analysis of long-range chromatin interaction and how transcription factors are involved to regulate gene expression, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

YALAMANCHILI H.K., Yan B., LI J., Qin J., Zhao Z., Chin F.Y.L. and Wang J.J., DDGni: Dynamic Delay Gene Network Inference from High Temporal Data using Gapped Local Alignment, Bioinformatics. 2013, 30(3): 377-383.

YALAMANCHILI H.K., Yan B., LI J., QIN J., Zhao Z., Chin F.Y.L. and Wang J.J., Inferring Gene Regulatory Network from Variable Delay High Temporal Data. , The 21st Annual International Conference on Intelligent Systems for Molecular Biology / 12th Annual European Conference on Computational Biology (ISMB/ECCB 2013), Berlin, Germany, 21-23 July 2013.. 2013.

YALAMANCHILI H.K., Li Z., Yao J.J. and Wang J.J., Recovering Isoform Specific Gene Regulatory Networks from RNA-SEQ Data , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Zhang L., Zhu C., Guo Y., Wei F., Lu J., Qin J., Banerjee S., Wang J.J., Shang H. and Verma S.C., Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-J , Journal of Virology. 2014.

Researcher : Wang P

List of Research Outputs

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

Researcher : Wang Y

List of Research Outputs

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

WANG Y., LI J. and Wang J.J., Analysis of Long-range Chromatin Interaction and How Transcription Factors are Involved to Regulate Gene Expression , 2013.

WANG Y., Induction of cells with osteo-chondrogenic potential by transcription factor-mediated reprogramming process , PhD Thesis, The University of Hong Kong. 2013.

Researcher : Wong BCW

List of Research Outputs

Tanner J.A., Bevan S.J., Cheng L.Y.L., Chan W.L. and Wong B.C.W., Promoting deep learning in biochemistry by diversifying assessment strategies – experience at the University of Hong Kong, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SA04-8, 626.

Researcher : Wong EYM

Project Title:	Boc associates with Cdo to negatively regulate sensory hair cell specification in Shh signaling pathway
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2013
Completion Date:	12/2014

List of Research Outputs

Researcher : Wong MK

List of Research Outputs

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	Investigation of threshold mechanisms in cellular responses to stress
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2014

Project Title:	Hydrogen peroxide signaling - the role of thioredoxin reductase
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	The relatioship between glycolysis and gluconeogenesis in cancer cells
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014

List of Research Outputs

Liu J., Xu A., Lam K.S.L., Wong N.S., CHEN J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, Oncotarget . 2013, 4: 1804-18.

MUNG K.L. and Wong N.S., Defining the Effects of Hypoxia on Glycogen Metabolism in Cancer Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

MUNG K.L. and Wong N.S., The Biochemical Mechanism Of Hypoxia-induced Mobilization Of Glycogen In Cultured Cancer Cell, Metabolism, Diet and Disease 2014: Cancer and metabolism. 2014.

MUNG K.L. and Wong N.S., The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

WONG P.Y. and Wong N.S., Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect., 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Wong N.S., Academic Editor, PlosONE. 2013.

Researcher : Wong PMM

List of Research Outputs

Wong P.M.M., Certificate in Introduction to Teaching and Learning @ HKU, The University of Hong Kong. 2013.

Wong P.M.M., Certificate of Attendance at the Frontiers in Biomedical Research, LKS Faculty of Medicine, The University of Hong Kong. 2013.

Wong P.M.M., Certificate of Completion of the PBL Training Program for New Tutors, The PBL Sub-Committee, LKS Faculty of Medicine, The University of Hong Kong. 2014.

Researcher : Wong XHL

List of Research Outputs

Wong X.H.L., APDBN Travel Awards, Asia-Pacific Developmental Biology Network (APDBN). 2014.

Wong X.H.L., EMBO Bursaries For The FEBS EMBO 2014 Conference, EMBO. 2014.

Wong X.H.L., The Interplay between MT1-MMP and ADAMs in Vascular Development , The 47th Annual Meeting for the Japanese Society of Developmental Biologists (JSDB). 2014.

Researcher : Wong YME

Project Title:	Boc associates with Cdo to negatively regulate sensory hair cell specification in Shh signaling pathway
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2013
Completion Date:	12/2014

List of Research Outputs

WANG B., Wong Y.M.E., HOR H.H., Hui C.C. and Sham M.H., Gli3 repressor is required to mediate the timing of mammalian cochlear hair cell differentiation., The 47th Annual Meeting of the Japanese Society of Developmental Biologists, Nogoya, Japan, May 28-30, 2014.

WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

WANG B., Wong Y.M.E., Liu Y., Hui C.C. and Sham M.H., Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, Lucca, Italy, March 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Wu MH

List of Research Outputs

YIP K.H.R., Wu M.H., Hui C.C., Chan D. and Cheah K.S.E., Gli-mediated regulation of Sox9 in limb development., 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong, November 24-27, 2013.. 2013.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : Wu X

List of Research Outputs

Osorio Da Silva L.A., Wu X. and Zhou Z., Distinct spatiotemporal expression of ISM1 during mouse and chick development, Cell Cycle. 2014, 13: 1571-1582.

Researcher : XIE S

List of Research Outputs

XIE S., Lu Y., Jean J., Sun H., Xia J. and Qian C., Structure of RPA32 Bound to N-terminus of SMARCAL1 Redefines the Binding Interface between RPA32 and its Interacting Proteins , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

XIE S., Mortusewicz O., Ma K., Poon R., Helleday T. and Qian C., Timeless-Parp1 complex facilitates homologous recombination repair, 2014 Hong Kong Inter-University Postgraduate Symposium on Life Science. 2014.

Researcher : XIONG C

List of Research Outputs

ZHANG Y., Xiong C., Chan W.C.W., Tam V., Sakai D. and Chan D., Are There Protective Genes for Disc Degeneration? , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., Xiong C., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice., World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., XIONG C., Chan W.C.W., SAKAI D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : XU F

List of Research Outputs

QIN J., HU Y.H., XU F. and Wang J.J., Inferring Gene Regulatory Networks from Integrative Omics Data via LASSO-type regularization methods., International Conference on Systems Biology, Huangshan, China, 23-25 August 2013.. 2013.

Qin J., Hu Y., XU F., YALAMANCHILI H.K. and Wang J.J., Inferring gene regulatory networks by integrating ChIP-seq/chip and transcriptome data via LASSO-type regularization methods, Methods. 2014.

WANG W., XU F., WANG P., LI J., Sham P.C. and Wang J.J., Assessment of Aligner and SNP Caller for Next Generation Sequencing and a Fast and Accurate SNP Detection Method., The 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2013) and the 12th Annual European Conference on Computational Biology (ECCB), Berlin, Germany,19-23 July, 2013.

WANG W., XU F. and Wang J.J., Assessment of Mapping and SNP-Detection Algorithms for Next-Generation Sequencing Data in Cancer Genomics, In: Wei Wu, Hani Choudhry, Next Generation Sequencing in Cancer Research. New York, NY, Springer New York, 2013, 301-317.

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

XU F., ISCB travel fellowships, The 17th Annual International Conference on Research in Computational Molecular Biology (RECOMB-2013), Beijing, China.. 2013.

Researcher : XU Y

List of Research Outputs

XU Y., Hor H.H., Hui C.C. and Sham M.H., The role of Suppressed of Fused in neural stem cell proliferation, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : XUE W

List of Research Outputs

Gan H., Zhu G., XUE W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, The Croucher Foundation Advanced Study Institiue: Integrative Approaches to Understanding Disorders of the skeleton. 2013.

XUE W., Gan H., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is Involved in Chondrocytes Interaction with Extracellular Matrix, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. . 2013.

Researcher : Xiong C

List of Research Outputs

Researcher : YALAMANCHILI HK

List of Research Outputs

Qin J., Hu Y., XU F., YALAMANCHILI H.K. and Wang J.J., Inferring gene regulatory networks by integrating ChIP-seq/chip and transcriptome data via LASSO-type regularization methods, Methods. 2014.

Wang P., Lai W.F., Li J., Xu F., Yalamanchili H.K., Lovell-Badge R. and Wang J.J., Inference of Gene-Phenotype Associations via Protein-Protein Interaction and Orthology, PLoS One. 2013, 8(10): e77478.

YALAMANCHILI H.K., Yan B., LI J., Qin J., Zhao Z., Chin F.Y.L. and Wang J.J., DDGni: Dynamic Delay Gene Network Inference from High Temporal Data using Gapped Local Alignment, Bioinformatics. 2013, 30(3): 377-383.

YALAMANCHILI H.K., Yan B., LI J., QIN J., Zhao Z., Chin F.Y.L. and Wang J.J., Inferring Gene Regulatory Network from Variable Delay High Temporal Data. , The 21st Annual International Conference on Intelligent Systems for Molecular Biology / 12th Annual European Conference on Computational Biology (ISMB/ECCB 2013), Berlin, Germany, 21-23 July 2013.. 2013.

YALAMANCHILI H.K., Li Z., Yao J.J. and Wang J.J., Recovering Isoform Specific Gene Regulatory Networks from RNA-SEQ Data , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : YANG X

List of Research Outputs

YANG X. and Zhou Z., Regulation of UHRF1 Post Transcriptional Modifications in DNA Damage and Cell Cycle , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : YAO Q

List of Research Outputs

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stress and hypoxic pathways in chondrocytes, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Researcher : YIP KHR

List of Research Outputs

YIP K.H.R., Wu M.H., Hui C.C., Chan D. and Cheah K.S.E., Gli-mediated regulation of Sox9 in limb development., 9th Pan Pacific Connective Tissue Societies Symposium - The Extracellular Matrix Niche Hong Kong, November 24-27, 2013.. 2013.

YIP K.H.R., Hong Kong Joint Universities Summer Teaching Laboratory Scholarship Funding 2013/2014 , Croucher Foundation. 2014.

YIP K.H.R., Wu M.H., Hui C.C., Chan D., Cheah K.S.E. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

YIP K.H.R., Kurt and Rhoda Isselbacher Endowed Scholarship Fund 2013/2014, Marine Biological Laboratory . 2014.

YIP K.H.R., Pfizer Inc. Endowed Scholarship 2013/2014, Marine Biological Laboratory. 2014.

YIP K.H.R., Reaching Outstanding Award, HKSAR Government Scholarship Fund 2013/2014. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H. and Cheah K.S.E., The roles of Sox9 and its regulatory elements in Campomelic Dysplasia. , Embryology: Concepts & Techniques in Modern Developmental Biology, Marine Biological Laboratory, Woods Hole, Massachusetts, US, June 7 – 21, 2014. . 2014.

Researcher : YU Y

List of Research Outputs

YU Y. and Tanner J.A., A novel aptamer-mediated approach for degenerative disc disease therapy, 9th Pan Pacific Connective Tissue Societies Symposium, Hong Kong . 2013.

YU Y., Chan D., Cheah K.S.E. and Tanner J.A., DNA aptamers can discriminate between closely related aggrecanase drug targets for degenerative disc disease therapy, 50th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery, Rouen, France. 2014.

YU Y. and Tanner J.A., Discriminatory Targeting of ADAMTS Aggrecanases for High-specificity Therapeutics Development for Degenerative Disc Disease , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

YU Y. and Tanner J.A., Discriminatory targeting of ADAMTS aggrecanases for high-specificity therapeutics development for degenerative disc disease, HKU 18th Research Postgraduate Symposium, Hong Kong . 2013.

Researcher : YUEN KS

List of Research Outputs

Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744.

Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87.

Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876.

YUEN K.S., Tang H.M.V., Kok K.H. and Jin D., Roles of Epstein-Barr Virus-encoded miR-BART microRNAs in Nasopharyngeal Epithelial Tumorigenesis, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Yalamanchili HK

List of Research Outputs

Researcher : Yang W

Project Title:	Meta-Analysis of two Asian GWAS datasets for identification of novel genetic variants associated with systemic lupus erythematosus
Investigator(s):	Yang W, Lau YL, Sham PC, Yang J
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Gene-based meta-analysis and further replication of SLE susceptibility genes in Asians
Investigator(s):	Yang W
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013
Completion Date:	06/2014

Project Title:	Annual meeting of American Society of Human Genetics; Massively parallel sequencing as a tool for HLA typing
Investigator(s):	Yang W
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2013

Project Title:	Identifying susceptibility genes in the human MHC region independently associated with systemic lupus erythematosus (SLE) in Chinese populations
Investigator(s):	Yang W, Lau YL, Sham PC
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Molecular diagnosis for severe combined immunodeficiencies (SCID) using whole exome sequencing
Investigator(s):	Yang W, Lau YL, Lee PPW, Chung BHY, Yang J
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2014

Project Title:	Development of a database on genetic variants found by Whole Exome Sequencing to aid variant filtering and prioritization in genetic studies
Investigator(s):	Yang W, Ying D, Yang J
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

WANG P., Siu K.L., Yang W., Zhang Y. and Kok K.H., Roles of a Novel Splice Variant of Human IFI16 in Innate Immune Response , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Secreted PDZ domain-containing protein 2 and regulation of Sonic hedgehog signaling during neural tube development
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

List of Research Outputs

FAN W., Lu X., Yao K.M. and Huang W., Toward Exploring Pluripotency Landscape Through Light-induced Tuning of Oct4 Expression, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the Role of FoxM1 in the Maintenance of Human Embryonic Stem Cell Pluripotency , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

KWOK C.T.D., LEUNG M.H., Lee C.Y.L. and Yao K.M., Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

LEUNG M.H., KWOK C.T.D., Liu B., Lee C.Y.L. and Yao K.M., Investigating the Protective Role of FOXM1 against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

LEUNG M.H., KWOK C.T.D., Lee C.Y.L. and Yao K.M., Investigating the protective role of FOXM1 against oxidative stress and DNA damage in human embryonic stem cells, 12th Annual Meeting of the International Society for Stem Cell Research, Vancouver, Canada, June 18-21, 2014.

LI C., Liu V.W.S., Chiu P.M., Yao K.M., Ngan H.Y.S. and Chan D.W., Reduced expression of AMPK-beta1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer, In: Christophe Nicot, Molecular Cancer. United Kingdom, BioMed Central, 2014, 13: 49.

Liu V.W.S., Tam C.W., Yao K.M. and Shiu S.Y.W., Activation of nuclear factor kappa B by androgen receptor splice variant AR-V7 in 22Rv1 Castration-resistant prostate cancer cells, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 12-14, 2014.

NGAN W.L. and Yao K.M., The Interplay between EPS8 and FOXM1 in Carcinogenesis , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Modulator of Hedegehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

TSUI M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., sPDZD2: A Novel Negative Modulator of Hedgehog Signaling, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 14, 2014.

WONG S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Hydrogel-based Cell Encapsulating Gel for Sustained Intraocular Drug Delivery, Ninth International Symposium on Healthy Aging: “Aging with Confidence”. 2014.

Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013.

Yao K.M., The Proliferation-associated Forkhead Box Transcription Factor FOXM1: Friend or Foe?, Invited lecture at Department of Biomedical Engineering, College of Biology, Hunan University. 2013.

Yung M.H., Chan D.W., Liu V.W.S., Yao K.M. and Ngan H.Y.S., Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade, BMC Cancer. 2013, 13: 327.

Researcher : Yee FYA

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P.J., Mannikko M., Makela P., Karppinen J., Jarvelin M.R., O'Reilly P.F., Kubo M., Kimura T., Kubo T., Toyoma Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant., J. Clin. Invest . 2013, 123: 4909-4917.

Wang A.M., Cao P., Yee F.Y.A., Chan D. and Wu E.X., Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy, Magn Reson Med. 2014, doi:10.1002/mrm.25289[Epub ahead of print].

Yee F.Y.A., Tam V., Cheah K.S.E., Cheung K.M.C. and Chan D., Analysis Of The Static Protein Profile Of Degenerated Ivd Indicate Increased Fibrosis-related Proteins, World Forum For Spine Research, 2014 (Xian). 2014.

Yee F.Y.A., Tam V., Cheung K.M.C. and Chan D., Proteomics Analysis Of The Human Intervertebral Disc Reveals Potential Fibrotic Events In Degeneration , 9th Pan Pacific Connective Tissue Societies Symposium. 2013.

Yee F.Y.A., Song Y., Chan D. and Cheung K.M.C., Understanding the Basis of Genetic Studies: Adolescent Idiopathic Scoliosis as an Example, Spine Deformity. 2014, 2: 1-9.

Researcher : Yip MS

Project Title:	World Forum for Spine Research 2014; Role of Type II Collagen Cleavage and Immune Responses in Intervertebral Disc Degeneration In Vivo
Investigator(s):	Yip MS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014
Completion Date:	05/2014

List of Research Outputs

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., Effect of impaired matrix turnover on differentiation of intervertebral disc cells, 9th Pan Pacific Connective Tissue Symposium, Hong Kong, 24-27th Nov 2013. . 2013.

Ng V.C.W., Chan W.C.W., Yip M.S., Gauci S., Fosang A. and Chan D., The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells, World Forum for Spine Research 2014, Xian, China, 15 - 17th May 2014.

Researcher : Yuen KS

List of Research Outputs

Researcher : Yung SSY

Project Title:	The role of annexin II and IL-6 in peritoneal inflammation and fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2014

Project Title:	The Role of Fibronectin in Peritoneal Inflammation and Fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	The role of microRNAs in fibrogenic processes in mesothelial cells
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	ASN Kidney Week 2013 Annual Meeting; Hyaluronan Exacerbates Renal Fibrosis in NZB/W Mice through Increased MCP-1 and TGF-β1 Secretion by Mesangial Cells
Investigator(s):	Yung SSY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2013
Completion Date:	11/2013

Project Title:	The role of hyaluronan in peritoneal inflammation and fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase is a regulator of ovarian cancer metastasis via crosstalk between P-cadherin-beta1-integrin signaling axes., The 20th Hong Kong International Cancer Congress. 2013.

Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase promotes a critical step in ovarian cancer metastasis by modulating tumor-mesothelial cell adhesion through P-cadherin-beta1-integrin crosstalk., The European Cancer Congress 2013.

Researcher : ZHANG H

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, Lucca, Italy, March 2014.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : ZHANG S

List of Research Outputs

ZHANG S. and Zhou Z., The Role of Nuclear Membrane-type Matrix Metalloproteinase I (MT1-MMP) in Cancer , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : ZHANG Y

List of Research Outputs

ZHANG Y., Xiong C., Chan W.C.W., Tam V., Sakai D. and Chan D., Are There Protective Genes for Disc Degeneration? , World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., Xiong C., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice., World Forum for Spine Research - Intervertebral Disc—from Degeneration to Therapeutic Motion Preservation Xi'An, China, May 15-17, 2014.. 2014.

ZHANG Y., XIONG C., Chan W.C.W., SAKAI D. and Chan D., Roles of Progenitor Cells for Intervertebral Disc Regeneration in "Healer" Mice, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHANG Y., Chan W.C.W., Sakai D. and Chan D., The Influence of Progenitor Cells in Intervertebral Disc Degeneration and Regeneration , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

Researcher : ZHENG F

List of Research Outputs

ZHENG F. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

ZHENG F., Li T., Cheung M.C.H., Syrovatkina V. and Fu C., Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips. , FEBS Lett . 2014, 588(6): 859-865.

Researcher : ZHOU J

List of Research Outputs

ZHOU J., MT1-MMP Regulates Central Nervous System Development through Notch Signaling, Ph.D Thesis, The University of Hong Kong. 2013.

Researcher : Zhang B

List of Research Outputs

HUA Y., Zhang B., Liu C.Y., Cai J. and Huang J., Development of a Virosome Vaccine against Aspergillus Fumigatus , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Researcher : Zhang M

List of Research Outputs

LI Z., Leung C., Zhang M., Sit H.M. and Sham M.H., The role of Sox10 in enteric neural crest cell migration, 2014 Hong Kong Inter-University Biochemistry Postgraduates Symposium, June 14, 2014.

Researcher : Zheng H

List of Research Outputs

Liu J., Yin X., Liu B., Zheng H., Zhou G., Gong L., Li M., Li X., Wang Y. and Hu J., HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells, Cell Cycle. 2014, 13: 1237-1247.

Xiong X., Wang J., Zheng H., Jing Z., Liu Z., Zhou Z. and Liu X., Identification of FAM96B as a novel prelamin A binding partner, Biochemical and Biophysical Research Communications. 2013, 440: 20-24.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Ageing and longevity: biology and challenge
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	02/2009

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Isthmin In Fibroblast Growth Factor Signaling and Nodal Signaling during Embryogenesis and Development
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2011

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	MT1-MMP-mediated ADAM15 shedding in angiogenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Novel SIRT1 activator
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

Project Title:	Chromatin remodeling in laminopathy-based progeria
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2013

Project Title:	Biology of Aging; Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2013
Completion Date:	08/2013

Project Title:	Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2013

Project Title:	Regulation of heterochromatin remodeling in DNA repair and aging
Investigator(s):	Zhou Z, Hao Q, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	02/2014

Project Title:	Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2014

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates the Lineage Progression of Hypertrophic Chondrocytes, 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.

GHOSH S. and Zhou Z., Role of nuclear lamins in the regulation of SIRT6, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014.

Ghosh S. and Zhou Z., Genetics of aging, progeria and lamin disorders, Current Opinion in Genetics & Development. 2014, 26: 41-46.

HU X. and Zhou Z., UHRF1 in Hedgehog signalling and basal cell carcinoma, 2nd HEALING International Meeting on Hh-Gli Signalling in Stem cells, Regeneration and Cancer. Arolla, Switzerland. 2013.

Liu B. and Zhou Z., Depletion of SUV39 ameliorates progeroid phenotypes and extends lifespan in accelerated aging mice, Gordon Research Conference on Aging: The Biology of Aging. Lucca, Italy, 2013.

Liu H., Lu S., Ho W.L., Tse H.M., Pang S.Y.Y., Kung M.H.W., Ho W.M., Ramsden D.B., Zhou Z. and Ho S.L., LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. , Annals of Clinical and Translational Neurology. 2014, 1(3): 199-208.

Liu H., Ho W.L., Tse H.M., Leung C.T.G., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice are more susceptible to rotenone toxicity , 18th International Congress of Parkinson’s Disease and Movement Disorders, June 2014, sweden.. 2014, 29.

Osorio Da Silva L.A., Wu X. and Zhou Z., Distinct spatiotemporal expression of ISM1 during mouse and chick development, Cell Cycle. 2014, 13: 1571-1582.

Xiong X., Wang J., Zheng H., Jing Z., Liu Z., Zhou Z. and Liu X., Identification of FAM96B as a novel prelamin A binding partner, Biochemical and Biophysical Research Communications. 2013, 440: 20-24.

YANG X. and Zhou Z., Regulation of UHRF1 Post Transcriptional Modifications in DNA Damage and Cell Cycle , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

ZHANG S. and Zhou Z., The Role of Nuclear Membrane-type Matrix Metalloproteinase I (MT1-MMP) in Cancer , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013.

Zhou Z., Academic Editor, PLoS ONE. 2014.

Zhou Z., Cell Surface Proteolysis and growth factor signalling control in development, Emerging Roles of Cell-Matrix Interaction in Human Diseases. Seoul, Korea, 2013.

Zhou Z., Epigenetic regulation and stem cell contribution in HGPS, Australia-China Biomedical Research Conference & 2013 International Symposium on Aging Biology and Diseases. Hangzhou, China, 2013.

Zhou Z., Laminopathy-based premature Aging, Advanced Study Institute: The Biology of Aging. Hong Kong, 2013.

Zhou Z., Stem Cell decline and Aging, 4Th Cell Biology Conference of Chinese Medical Society. Shenyang, 2013.

Zhou Z., Stem Cells in Premature Aging, Cold Spring Harbor Asia conference on Molecular Basis of Aging and Disease,. 2013.

Zhou Z., UHRF1 in Basal Cell Carcinoma, 22nd Asia Pacific Cancer Conference. Tianjin, China, 2013.

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