DEPT OF ANATOMY
| Researcher : Chan CWY |
| Project Title: | Human embryonic stem cell-derived cardiomyocyte as a model to study the role of autophagy in cardiac inflammation |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Completion Date: | 11/2016 |
| List of Research Outputs |
| Sun Y., Zhang Y., Li X., Deng M., Gao W., Yao Y., CHIU S.M., LIANG X., GAO F., Chan C.W.Y., Tse H.F., Shi J., Fu Q. and Lian Q., Insensitivity of Human iPS Cells-derived Mesenchymal Stem Cells to Interferon-γ -induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice, STEM CELLS. 2015, n/a-n/a. |
| chen G., Karakilkes I., Chow M.Z.Y., Chopra A., Keung W., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs., 2015, 8. |
| Researcher : Chan TK |
| Project Title: | Redeveloping a governance model of the complaint-handling process for sufficient, accountable and transparent regulation of medical professionals in Hong Kong |
| Investigator(s): | Chan TK |
| Department: | Anatomy |
| Source(s) of Funding: | Public Policy Research Funding Scheme |
| Start Date: | 01/2015 |
| Researcher : Chang R.C.C. |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung HLC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung HLC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | Society for Neuroscience 2015; Proteasome and autophagic degradation in an In vitro model of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Investigating the significance of JNK3 and PKR in modulating the fate of neurons in cigarette smoking-induced neurodegeneration as risk factor of Alzheimer's disease |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung HLC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung HLC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | Society for Neuroscience 2015; Proteasome and autophagic degradation in an In vitro model of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Investigating the significance of JNK3 and PKR in modulating the fate of neurons in cigarette smoking-induced neurodegeneration as risk factor of Alzheimer's disease |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Chiu P.W., Hui S.K., Chan Q., Aman R.R.A.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Selected Proffered Paper: Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices, In: Prof. Peter B. Barker, The 24th Annual Meeting of ISMRM: Psychiatric MR Spectroscopy & Imaging Study Group. 2016. |
| GONG Z., You R., Chang R.C.C. and Lin Y., Viscoelastic response of neural cells governed by the deposition of amyloid-ß peptides (Aß), Journal of Applied Physics. 2016, 119: 214701. |
| Wang H., Lau B.W.M., Wang N.L., Wang S.Y., L Q.J., Chang R.C.C. and So K.F., Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells, Neural Regeneration Research. Neural Regeneration Research, 2015, 10: 1976. |
| Zhang L.Q., Sa F., Chong C.M., Wang Y.S., Zhou Z.Y., Chang R.C.C., Chang S.W., Hoi P.M. and Lee S.M.Y., Schisantherine A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3b pathways, Journal of Ethnopharmacology. 2015, 170: 8-15. |
| Researcher : Chau RMW |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 The Possible Mechanism of Action for Quinacrine Interacting the Scrapie Protein in Prion Disease |
| Investigator(s): | Chau RMW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Researcher : Chen AYS |
| Project Title: | Study of the role of polyol pathway activation the impaired nerve regeneration in diabetes |
| Investigator(s): | Chen AYS, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Cheung A |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4 |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Cheung A. |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4 |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Cheung ALM |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4 |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Cheung MCH |
| Project Title: | Investigating the roles of SOX9 in human neural stem cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2014 |
| Project Title: | Single-cell transcriptomics in Sertoli cells and neural crest cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression |
| Investigator(s): | Cheung MCH, Lung HL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Project Title: | Elucidating the role of Sox9 in cell fate acquisition of neural crest progenitors in the dorsal root ganglia |
| Investigator(s): | Cheung MCH, Sham MH, Lui VCH, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Project Title: | Avian Model Systems 9: A New Integrative Platform; Coordinated action of Dlc1 and Nedd9 in neural crest motility |
| Investigator(s): | Cheung MCH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2016 |
| Completion Date: | 03/2016 |
| Project Title: | Elucidating the role of Dlc1beta in motor neuron development |
| Investigator(s): | Cheung MCH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Researcher : Ching Y.P. |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | A study of the role of CDK5RAP3 in neuronal cell differentiation |
| Investigator(s): | Ching YP, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Characterization of novel HBx regulated gene in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | A study of the role of CDK5RAP3 in neuronal cell differentiation |
| Investigator(s): | Ching YP, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Characterization of novel HBx regulated gene in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Researcher : Chung SK |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Completion Date: | 08/2015 |
| Project Title: | Aldose Reductase(AR) effect dopaminergic neuronal autophagy through microglia after acute inflammation in Parkinson’s disease |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | To determine the role of Exchange Proteins Directly Activated by cAMP (Epac) in the gut microbiota-mediated metabolic syndrome |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Molecular basis of beta3-adrenergic receptor agonists on anxiolytic-and anti-depressive action: cAMP/Epac2 as a potential signal to improve neuronal mitochondrial biogenesis and neurogenesis. |
| Investigator(s): | Chung SK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| LUO X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. , In: Xin Luo, Xiaoming Amy Wang, Zhengyuan Xia, Sookja Kim Chung and Chi Wai Cheung, Review in Neurosciences. 2015, 27(1): 83-92. |
| Researcher : Deng W |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 08/2016 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2013 |
| Completion Date: | 11/2015 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization |
| Investigator(s): | Deng W, Tsao GSW, Chen H |
| Department: | School of Nursing |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Immortalization of human uterine cervical epithelial cells without viral oncogene expression |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| Researcher : Deng W. |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 08/2016 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2013 |
| Completion Date: | 11/2015 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization |
| Investigator(s): | Deng W, Tsao GSW, Chen H |
| Department: | School of Nursing |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Immortalization of human uterine cervical epithelial cells without viral oncogene expression |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Researcher : Ellis-Behnke RG |
| Project Title: | The ADME of Self-assembling Nanomaterials |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Incorporation Dynamics of Additives and Self-assembly peptides (SAPs) at Nanoscale for Central Nervous System (CNS) Regeneration |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2009 |
| Researcher : Feng W |
| Project Title: | Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses |
| Investigator(s): | Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Researcher : He L |
| List of Research Outputs |
| He L., Tian L., Sun Y., Zhang Y., Xue W., So K.F., Ramakrishna S. and Wu W., Nano-Engineered Environment for Nerve Regeneration: Scaffolds, Functional Molecules and Stem Cells, Current Stem Cell Research & Therapy, 2016, 11, 00-00. 2015. |
| Researcher : Huen M.S.Y. |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Genomic Integrity - Zing Conferences; Towards defining chromatin dynamics at DNA double-strand breaks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Young Researcher Award 2014-15 |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases |
| Investigator(s): | Huen MSY, Lau CYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2016 |
| Project Title: | Role of HAUSP in DNA Damage Signal Transduction |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Huen MSY |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Genomic Integrity - Zing Conferences; Towards defining chromatin dynamics at DNA double-strand breaks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Young Researcher Award 2014-15 |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases |
| Investigator(s): | Huen MSY, Lau CYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2016 |
| Project Title: | Role of HAUSP in DNA Damage Signal Transduction |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Hugon J |
| Project Title: | Society for Neuroscience 30th Annual Meeting Tau Phosphorylation during neuronal Apoptosis Induced by NMDA Receptor Blockade: an in Vivo Study |
| Investigator(s): | Hugon J |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Researcher : Lau CF |
| List of Research Outputs |
| Poon D.C.H., Ho Y.S., Lau C.F. and Chang R.C.C., Oral feeding of minocycline attenuates glial activation and reductions of tau and drebrin in response to systematically injected cytokines. , Hong Kong Medical Journal. 2016, 22 Suppl.3: 16-21. |
| Researcher : Lau MY |
| List of Research Outputs |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Law WT |
| List of Research Outputs |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Li B |
| Project Title: | International Conference on Antimicobial Agents and Chemtherapy; Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance |
| Investigator(s): | Li B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| List of Research Outputs |
| Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18. |
| Researcher : Lin B |
| Project Title: | Modulation of the PTEN/mTOR pathway enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Completion Date: | 07/2016 |
| Project Title: | Cyclooxygenase-1 deletion enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 06/2016 |
| Project Title: | Ectopic expression of the light-sensitive protein melanopsin in rod photoreceptors prevents retinal degeneration |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Cyclooxygenase-1 deletion promotes microglia quiescence and enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Inhibition of colony-stimulating factor 1 receptor signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Inhibition of colony-stimulating factor 1 receptor (CSF1R) signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 07/2016 |
| Project Title: | annual meeting of the association for research in vision and ophthalmology ; PTEN deletion enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Researcher : Ling MT |
| Project Title: | The regulation and role of Id-1 in prostate cancer progression |
| Investigator(s): | Ling MT, Wong YC, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | The role of EMI1 in prostate carcinogenesis |
| Investigator(s): | Ling MT, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2007 |
| Project Title: | The role of Daxx in chromosome instability and prostate carcinogenesis |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2008 |
| Researcher : Ma SKY |
| Project Title: | Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells |
| Investigator(s): | Ma SKY, Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma |
| Investigator(s): | Ma SKY, Chan KW |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Outstanding Young Researcher Award 2012-13 |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | A multidisciplinary study on hepatic cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 04/2014 |
| Project Title: | miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 08/2015 |
| Project Title: | Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2015 |
| Project Title: | PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications |
| Investigator(s): | Ma SKY, Guan X, Lo CM, Man K |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2015 |
| Project Title: | PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF |
| Investigator(s): | Ma SKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer |
| Investigator(s): | Ma SKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Won C., Kim B.H., Yi E.H., Choi K.J., Kim E.K., Jeong J.M., Lee J.H., Jang J.J., Yoon J.H., Jeong W.I., Park I.C., Kim T.W., Bae S.S., Factor V.M., Ma S.K.Y., Thorgeirsson S.S., Lee Y.H. and Ye S.K., STAT3-mediated CD133 upregulation contributes to promotion of hepatocellular carcinoma, Hepatology. 2015. |
| Researcher : Ng KY |
| Project Title: | Role of LOXL1 in CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ng KY, Huen MSY, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| Researcher : Ng TW |
| Project Title: | Evaluating the effect of prostaglandin-E2 EP4 receptor signaling |
| Investigator(s): | Ng TW, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| Researcher : So K.F. |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Completion Date: | 11/2016 |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects |
| Investigator(s): | So KF, Wu W, Lee TMC |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice |
| Investigator(s): | So KF, Xu A |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Researcher : So KF |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Completion Date: | 11/2016 |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects |
| Investigator(s): | So KF, Wu W, Lee TMC |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice |
| Investigator(s): | So KF, Xu A |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Lin J., Chan K.W., Lee H.M.E., Chang W.C., Tse M.A., Su W.W., Sham P.C., Hui C.L.M., Joe G.M., Chan C.L.W., Khong P.L., So K.F., Honer W. and Chen E.Y.H., Aerobic Exercise and Yoga Improve Neuro-Cognitive Function in Women with Early Psychosis: Effects of a Randomized Controlled Trial, NPJ Schizophrenia. 2015. |
| Researcher : Sy MH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | The role of DNA Damage Response in Genomic Instability Observed in Hepatocellular Carcinoma |
| Investigator(s): | Sy MH, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Completion Date: | 06/2016 |
| Project Title: | Genomic Integrity Conference; ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response |
| Investigator(s): | Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | The role of DNA Damage and Repair Signaling in Hepatocarcinogenesis |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Researcher : Sy SMH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | The role of DNA Damage Response in Genomic Instability Observed in Hepatocellular Carcinoma |
| Investigator(s): | Sy MH, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Completion Date: | 06/2016 |
| Project Title: | Genomic Integrity Conference; ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response |
| Investigator(s): | Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | The role of DNA Damage and Repair Signaling in Hepatocarcinogenesis |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Researcher : Tipoe GL |
| Project Title: | 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2013 |
| Project Title: | Multifunctional M30 drug down-regulates carbon tetrachloride (CCl4) – induced hepatic oxidative stress, inflammation and apoptosis in vitro and in vivo models |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | The regulation of cylcooxygenase-1 in a carbon tetrachloride induced acute liver injury animal model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Project Title: | Therapeutic effects of Wolfberry (Lycium barbarum polysaccharides; LBP) in non-alcoholic fatty liver disease (NAFLD) animal models |
| Investigator(s): | Tipoe GL, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Novel anti-hepatic cancer properties of garlic-derived SAMC through direct targeting of LRP6/Wnt signaling pathway |
| Investigator(s): | Tipoe GL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Researcher : Tong M |
| Project Title: | The clinical and functional significances of glucose transporter, isoform 3 (GLUT3) in CD133+ liver cancer stem cells driven Hepatocellular carcinoma |
| Investigator(s): | Tong M, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Researcher : Tsang C.M. |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Completion Date: | 04/2016 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | Potentiation of tumor-associated macrophages (TAMs)-induced invasiveness in EBV-associated nasopharyngeal epithelial cells |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2015 |
| Researcher : Tsang CM |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Completion Date: | 04/2016 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | Potentiation of tumor-associated macrophages (TAMs)-induced invasiveness in EBV-associated nasopharyngeal epithelial cells |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2015 |
| Researcher : Tsao G.S.W. |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 06/2016 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| Project Title: | Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 07/2015 |
| Project Title: | Annul meeting 2016 of the American Association for Cancer Research; "Establishment and characterization of xenografts and cell lines trom nasopharyngeal carcinoma" |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| Project Title: | Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Researcher : Tsao GSW |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 06/2016 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| Project Title: | Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 07/2015 |
| Project Title: | Annul meeting 2016 of the American Association for Cancer Research; "Establishment and characterization of xenografts and cell lines trom nasopharyngeal carcinoma" |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| Project Title: | Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Cheung A.K.L., Dai W., LEONG M.L., Tsao G.S.W. and Lung M.L., EBV infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4m33 mark, 107th American Association for Cancer Research. 2016. |
| HONG M., Wang N., TAN H.Y., Tsao G.S.W. and Feng Y., MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy, Cancers. 2015, 7: 1643-1657. |
| Hui K.F., Cheung A.K.L., CHOI C.K., YEUNG P.L., Middeldorp J.M., Lung M.L., Tsao G.S.W. and Chiang A.K.S., Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir, Int J Cancer. 2015. |
| XIANG Z., Liu Y., Zheng J., GAO Y., LU A., Lam K.T., Chen H., Tsao G.S.W., Chan G.C.F., Lau Y.L. and Tu W., Faculty Outstanding Research Output Award., Faculty of Medicine, the University of Hong Kong. 2015. |
| XIANG Z., Liu Y., Zheng J., Lam K.T., GAO Y., Chan G.C.F., Chen H., Tsao G.S.W., Lau Y.L. and Tu W., Faculty Outstanding Research Output Award, Faculty of Medicine, the University of Hong Kong. 2015. |
| Researcher : Wang X |
| Project Title: | The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors |
| Investigator(s): | Wang X, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Lance Armstrong Foundation - General Award |
| Start Date: | 10/2003 |
| Project Title: | Significance of MAD2 expression to chromosomal instability in prostate cancer |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Association for International Cancer Research - General Award |
| Start Date: | 04/2004 |
| Project Title: | Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 08/2005 |
| Researcher : Wang X |
| Project Title: | Angio-(1-7) and ACE2 during normal and hypertensive pregnancy |
| Investigator(s): | Wang X, Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Wong YC |
| Project Title: | Induction of breast carcinogenesis by a combination of androgens and oestrogens |
| Investigator(s): | Wong YC, Xie B |
| Department: | Anatomy |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1997 |
| Project Title: | The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian |
| Investigator(s): | Wong YC, Wang X, Ho KMT |
| Department: | Anatomy |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Researcher : Wu W |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury |
| Investigator(s): | Wu W, Yick LW, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 11/2003 |
| Project Title: | Research Output Prize |
| Investigator(s): | Wu W, Su H, Wong WM, So KF, Wu EX |
| Department: | Anatomy |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 10/2008 |
| Project Title: | Fabrication of a bioactive nanofibrous conduit for functional recovery of spinal cord injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Project Title: | Spinal cord injury in developing and adult rats: different outcome and potential mechanisms. |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Repairing neural damage after spinal cord injury with self-assembling peptide nanofiber scaffold (SAPNS) |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Enhancing axonal regeneration of spinal motoneurons after root avulsion by manipulation of chondroitin sulfate proteoglycans (CSPGs) |
| Investigator(s): | Wu W |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| List of Research Outputs |
| He L., Tian L., Sun Y., Zhang Y., Xue W., So K.F., Ramakrishna S. and Wu W., Nano-Engineered Environment for Nerve Regeneration: Scaffolds, Functional Molecules and Stem Cells, Current Stem Cell Research & Therapy, 2016, 11, 00-00. 2015. |
| Researcher : XIAO J |
| List of Research Outputs |
| Jiao R., Liu Y., Gao H., Xiao J. and So K.F., The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides, The American Journal of Chinese Medicine. 2016, 44: 463-488. |
| XIAO J., Liu Y.X., Xing F.Y., Leung T.M., Liong E.C. and Tipoe G.L., Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway, European Journal of Nutrition. 2016, 55: 1465-1477. |
| Researcher : Xiao J |
| List of Research Outputs |
| Jiao R., Liu Y., Gao H., Xiao J. and So K.F., The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides, The American Journal of Chinese Medicine. 2016, 44: 463-488. |
| XIAO J., Liu Y.X., Xing F.Y., Leung T.M., Liong E.C. and Tipoe G.L., Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway, European Journal of Nutrition. 2016, 55: 1465-1477. |
| Researcher : Yang J |
| Project Title: | Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions |
| Investigator(s): | Yang J, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| Researcher : Yang J |
| List of Research Outputs |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Yeung PKK |
| Project Title: | The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice |
| Investigator(s): | Yeung PKK, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| Researcher : Yip HKF |
| Project Title: | In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death |
| Investigator(s): | Yip HKF, Tsao GSW, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2005 |
| Project Title: | Telomerase immortalization of retinal ganglion cells derived from the embryonic mouse retinal progenitor cells |
| Investigator(s): | Yip HKF, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Combined treatment of lithium and noggin inhibits astroglios after spinal cord injury by deactivation of GSK-3β/STAT3 are BMP/Smad pathways in the endogenous adult neural stem cells |
| Investigator(s): | Yip HKF, Shum DKY |
| Department: | Anatomy |
| Source(s) of Funding: | Spinal Cord Injury Research Grant |
| Start Date: | 05/2010 |
| Project Title: | Lithium treatment increases the expression of brain-derived neurotrophic factor in the injured adult spinal cord. |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Project Title: | International Society of Developmental Neuroscience Meeting; The Role of p300 in Regulating Endogenous Neural Progenitor Differentiation By The Combined Treatment Of Lithium and Noggin And Promoting Functional Recovery After Spinal Cord Injury. |
| Investigator(s): | Yip HKF |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| Researcher : Yip YL |
| Project Title: | Establishment and characterization of representative nasopharyngeal carcinoma cell lines |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| Completion Date: | 08/2015 |
| Researcher : Yu C |
| Project Title: | Down-regulation of integrin-beta3 by clathrin-mediated endocytosis |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 11/2014 |
| Project Title: | Investigating phosphatidylinositol lipid signaling at the cancer invadosome |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2015 |
| Project Title: | The mechanism of Cdc42 regulation in podosome assembly |
| Investigator(s): | Yu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Project Title: | Gordon Research Conference: Signaling by Adhesion Receptors; Regulation of integrin-beta3 endocytosis at adhesion sites |
| Investigator(s): | Yu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |