CENTRE FOR GENOMIC SCIENCES



Researcher : Cherny SS

Project Title:Variance components models for mapping QTLs
Investigator(s):Cherny SS, Sham PC
Department:Psychiatry
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:09/2006


Project Title:Exome sequencing of mesial temporal lobe epilepsy with hippocampal sclerosis in parent-offspring trios
Investigator(s):Cherny SS, Sham PC
Department:Psychiatry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Do de novo chromosomal abnormalities lead to sporadic biliary atresia?
Investigator(s):Cherny SS, Garcia-Barcelo MM, Tam PKH
Department:Psychiatry
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014


Project Title:American Society of Human Genetics Annual Meeting; SNP-based HLA tagging, imputation, and association in adverse drug reaction of epilepsy patients from Hong Kong
Investigator(s):Cherny SS
Department:Psychiatry
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2015
Completion Date:10/2015


List of Research Outputs

Gui H., Li M., Baum L., Kwan P. and Cherny S.S., Patterns of epilepsy-schizophrenia genetic correlation and sharing revealed by secondary analyses of GWAS data, 11th Asian & Oceanian Epilepsy Congress 2016, Hong Kong, China, 13-16 May 2016.. 2016.


Researcher : Fan Y

Project Title:Probabilistic Modeling in Genomics Meeting; HLAassoc: tests for association between HLA alleles and diseases
Investigator(s):Fan Y
Department:Centre for Genomic Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2015
Completion Date:10/2015


List of Research Outputs

Plani-Lam J.H., Chow T.C., Fan Y., Garcia-Bloj B., Cheng L., Jin D., Hancock W., Fanayan S., Ingley E. and Song Y., High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity, Blood Cancer J.. 2016, 15;6:e388.


Researcher : Gui H

Project Title:Identification for epilepsy-schizophrenia genetic sharing through multiple data mining approaches
Investigator(s):Gui H, Cherny SS, Li M, Sham PC
Department:Centre for Genomic Sciences
Source(s) of Funding:Small Project Funding
Start Date:03/2015
Completion Date:08/2016


Project Title:the 2015 American Society of Human Genetics Annual Meeting; Genome-wide gene-set analysis identifies different patterns of genetic sharing across complex phenotypes
Investigator(s):Gui H
Department:Centre for Genomic Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2015
Completion Date:10/2015


List of Research Outputs

Cherny S.S., Gui H., Kwok M., Sham P.C., Baum L.W. and Kwan P., SNP-based HLA tagging, imputation, and association in adverse drug reaction of epilepsy patients from Hong Kong, 65th Annual Meeting of the American Society of Human Genetics. 2015, 654/W.
Gui H., Kwan J., Sham P.C., Cherny S.S. and Li M., Genome-wide gene-set analysis identifies different patterns of genetic sharing across complex phenotypes, American Society of Human Genetics Annual Meeting 2015, Baltimore, USA, 6- 10 October 2015.
Gui H., Li M., Baum L., Kwan P. and Cherny S.S., Patterns of epilepsy-schizophrenia genetic correlation and sharing revealed by secondary analyses of GWAS data, 11th Asian & Oceanian Epilepsy Congress 2016, Hong Kong, China, 13-16 May 2016.. 2016.
Luzón-Toro B., Gui H., Tang S.M., Garcia-Barcelo M.M., Tam P.K.H., Sham P.C. and Cherny S.S., Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease, Scientific reports. 2015.
Tang S.M., Gui H., Cherny S.S., Sham P.C., Tam P.K.H. and Kim J.H., Trans-ethnic meta-analysis of Hirschsprung disease (Abstract and Poster Presentation), European Human Genetics Conference (ESHG) 2016, Barcelona, Spain, 21-24 May 2016.


Researcher : Lam SML

List of Research Outputs

Tang S.M., Zhang H., Cheung Y.Y., Xu M., Ho J.C.Y., Zhou W., Cherny S.S., Zhang Y., Holmen O., Au K.W., Yu H., Xu L., Jia J., PORSCH R.M., Sun L., Xu W., Zheng H., Wong L.Y., Mu Y., Dou J., Fong H.Y., Wang S., Hong X., Dong L., Liao Y., Wang J., Lam S.M.L., Su X., Yan H., Yang M.L., Chen J., Siu D.C.W., Xie G., Woo Y.C., Wu Y., Tan K.C.B., Hveem K., Cheung B.M.Y., Zöllner S., Xu A., Eugene Chen Y., Jiamg C.Q., Jiang Y., Lam T.H., Ganesh S.K., Huo Y., Sham P.C., Lam K.S.L., Willer C.J., Tse H.F. and Gao W., Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese, Nature Communications. 2015, 6: 10206.


Researcher : Li J

List of Research Outputs

Li J., Predicting regulatory variants with composite statistic, Bioinformatics. 2016, 32: 2729-2736.


Researcher : Lin C

List of Research Outputs

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.


Researcher : Sham PC

Project Title:Replication study of susceptibility genes for colorectal cancer
Investigator(s):Sham PC, Ho JWC, Cheng KK
Department:LKS Medical Faculty
Source(s) of Funding:Small Project Funding
Start Date:10/2007


Project Title:Partner State Key Laboratory of Brain and Cognitive Sciences
Investigator(s):Sham PC, So KF, Tan L
Department:Centre for Genomic Sciences
Source(s) of Funding:Matching Fund for State Key Laboratory (SKL)
Start Date:10/2008


Project Title:Visiting Research Professors Scheme 2009-10
Investigator(s):Sham PC
Department:LKS Medical Faculty
Source(s) of Funding:Visiting Research Professors Scheme
Start Date:09/2009


Project Title:Method and Software for Personal Risk Profiling of Complex Diseases
Investigator(s):Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W
Department:Psychiatry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012
Completion Date:12/2015


Project Title:Bioinformatics tools for identifying disease loci from exome sequencing data
Investigator(s):Sham PC, Cherny SS, Garcia-Barcelo MM, Li M, Yang W
Department:Psychiatry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Genomics
Investigator(s):Sham PC, Chin FYL, Leung FCC
Department:LKS Medical Faculty
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Cross Cultural Differences in Biased Cognition
Investigator(s):Sham PC, Chen EYH, Toulopoulou T
Department:LKS Medical Faculty
Source(s) of Funding:ESRC/RGC Joint Research Scheme
Start Date:09/2013


Project Title:Statistical methods for characterizing the genetic component of polygenic diseases
Investigator(s):Sham PC, Cherny SS
Department:Psychiatry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Mutational spectrum for dilated cardiomyopathy in Hong Kong
Investigator(s):Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M
Department:Centre for Genomic Sciences
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2014


Project Title:A novel computational framework to identify transcription factor-DNA interaction for cancer genomics
Investigator(s):Sham PC, Yao KM, Wong MP, Wang JJ
Department:LKS Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:08/2014


Project Title:Schizophrenia-related de novo and compound heterozygous mutations
Investigator(s):Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M
Department:LKS Medical Faculty
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015


Project Title:Method and software tool for estimating and dissecting the heritability of complex diseases
Investigator(s):Sham PC, Cherny SS, Li M
Department:LKS Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2015


List of Research Outputs

Cherny S.S., WONG K.L., Sham P.C., Baum L.W. and Kwan P., Exome sequencing of mesial temporal lobe epilepsy with hippocampal sclerosis in parent-offspring trios, Annual meeting of the Behavior Genetics Association. 2015.
Cherny S.S., Gui H., Kwok M., Sham P.C., Baum L.W. and Kwan P., SNP-based HLA tagging, imputation, and association in adverse drug reaction of epilepsy patients from Hong Kong, 65th Annual Meeting of the American Society of Human Genetics. 2015, 654/W.
Gui H., Kwan J., Sham P.C., Cherny S.S. and Li M., Genome-wide gene-set analysis identifies different patterns of genetic sharing across complex phenotypes, American Society of Human Genetics Annual Meeting 2015, Baltimore, USA, 6- 10 October 2015.
Kwan S.H., Li M., Deng S.J. and Sham P.C., FAPI: Fast and Accurate P-value Imputation for genome-wide association study., European Journal of Human Genetics. 2015.
LI Y., Samartzis D., Campbell D.D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Chan D. and Sham P.C., Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study, The Spine Journal. 2016, pii: S1529-9430(16)30095-X.
Li M.J., Liu Z., Wang P., Wong M.P., Nelson M., Kocher J.P.A., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J., GWASdb v2: an update database for human genetic variants identified by genome-wide association studies, Nucleic Acids Research. 2016, 44: D869-D876.
Luzón-Toro B., Gui H., Tang S.M., Garcia-Barcelo M.M., Tam P.K.H., Sham P.C. and Cherny S.S., Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease, Scientific reports. 2015.


Researcher : Wang JJ

Project Title:Outstanding Young Researcher Award 2011-12
Investigator(s):Wang JJ
Department:Biochemistry
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:01/2013


Project Title:Understanding the effects of DNA methylation on gene expression - a computational approach
Investigator(s):Wang JJ, Wong MP, Chim JCS
Department:Biochemistry
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2015


Project Title:ISMB/ECCB 2015 / NetBio SIG 2015; Prediction of determining factors and underlying gene regulatory network for cell fate conversion
Investigator(s):Wang JJ
Department:Centre for Genomic Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2015
Completion Date:07/2015


List of Research Outputs

Kwok C.T.D., LEUNG M.H., Qin J., QIN Y., Wang J.J., Lee C.Y.L. and Yao K.M., The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells, Stem Cell Research. 2016.
Lee V.H.F., Wang J.J., Xu J., Sihoe D.L.A. and Wong M.P., Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia, International Journal of Cancer. 2015, 137: 311-319.
Qin J., Yan B., Hu Y., Wang P. and Wang J.J., Applications of Integrative OMICs Approaches to Gene Regulation Studies, Quantitative Biology. 2016, 2: in press.
Wang J.J., Yan B., Liu S.M., Sun H., Pan Y., Guan D., Zhang X., Xu J. and Ma H., Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor, J Cancer. 2015, 6(10): 930-7.
Wang P., Qin J., Qin Y., Zhu Y., Wang L.Y., Li M.J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, The 23rd Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and the 12th Annual European Conference on Computational Biology (ECCB), Dublin, Ireland, 10-14 July 2015.. 2015.
Wei Z., Chang X. and Wang J.J., Advanced Computational Approaches for Medical Genetics and Genomics, BioMed Research International. 2015, 2015: 1-2.
Xiao B., Gu S.M., LI J., Li J., Tao B., Wang Y., Wang J.J., Li B., Patrignani P. and Yu Y., Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population, Arteriosclerosis, Thrombosis, and Vascular Biology. 2015, 35: 1687-1695.


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