Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au LKS

List of Research Outputs

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Au Yeung KHR

Project Title:	Identification of tumor suppressor receptor-type protein tyrosine phosphatases (R-PTPases) in nasal-type NK/T-cell lymphoma, and evaluation of their role as novel prognostic indicators and drug targets
Investigator(s):	Au Yeung KHR, Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Lam A.C., Au Yeung K.H.R. and Lau V.W., A rare disease in an atypical location-Kimura’s Disease of the upper extremity, Skeletal Radiology. 2015, 44: 1833-1837.

Ondrejka S.L., Moffitt A.B., Tse E.W.C., Hsi E.D., Goodlad J.R., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Gascoyne R.D., Rajagopalan D., Love C. and Dave S., Whole Exome Sequencing of Type 1 and Type 2 Enteropathy-Associated T Cell Lymphoma Reveals Genetic Basis of Eatl Oncogenesis, 57th American Society of Hematology Annual Meeting. American Society of Hematology, 2015, 126: 575.

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Beh S.L., Defending Cases, Pathology Update 2016 - Royal College of Pathologists of Australasia. 2016.

Beh S.L., Objection to Autopsy, Pathology Update 2016 - Royal College of Pathologists of Australasia. 2016.

Beh S.L., Pathologists As Communicators, Pathology Update 2016 - Royal College Of Pathologists Of Australasia. 2016.

Beh S.L., Responding to Disasters - What is ICRC doing to assist communities in their response to mass fatalities and in identification of the missing, Annual Conference On Disaster Preparedness And Response 2015.

Beh S.L., What Is An Autopsy, Pathology Update 2016 - Royal College Of Pathologists Of Australasia.. 2016.

Researcher : CHAN KS

List of Research Outputs

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Researcher : CHEN Q

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Researcher : CHENG YLB

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Chan ASY

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Chan GSW

List of Research Outputs

Chen J.Y., Chan G.S.W., Tsang K.F. and Tsang J.P.Y., The hospital mortuary: a place for learning about death…and life, 17th Ottawa Conference and the Australia New Zealand Association of Health Professions Educators (ANZAHPE) 2016 Conference. 2016.

Researcher : Chan HY

List of Research Outputs

Siu K.Y., Kong D.S., Ngai S.Y., Chan H.Y., Jiang L., Wong E.S.Y., Liu S., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation., PLoS One. 2015, 10(7): e0133467.

Researcher : Chan KK

Project Title:	iASPP and autophagy - novel molecular targets for ovarian clear cell carcinoma
Investigator(s):	Chan KK, Cheung ANY, Wong GW, Chan KKL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Roles of iASPP, PLK1 and autophagy in ovarian clear cell carcinoma
Investigator(s):	Chan KK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2015
Completion Date:	10/2015

List of Research Outputs

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Investigator(s):	Chan KW, Ma SKY, Law SYK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	A new tumor suppressor gene KIF7 inhibits tumor progression by suppressing Wnt/beta-catenin signaling in prostate cancer
Investigator(s):	Chan KW, Liu J
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

List of Research Outputs

Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255.

Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18.

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan LC

List of Research Outputs

Wong P.Y., Chan L.C., Chen J.Y. and Ho R.T.H., “A mixed method study on the psychological outcomes and students’ perception on mindful practice training” , 15th Annual Research Postgraduate Conference Faculty of Social Sciences, The University of Hong Kong (Jun 2015). 2016.

Researcher : Chan LK

Project Title:	AACR Annual Meeting 2016; Functional characterization of RPS6KA3 (RSK2) and identification of its naturally occurring mutants in hepatocellular carcinoma
Investigator(s):	Chan LK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.

RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016.

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2012

Researcher : Chan VSF

Project Title:	Proteomic analysis of CLEC16A interacting partners in autophagy
Investigator(s):	Chan VSF, Tam CY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	A study of interferon-induced chemokines signature in lupus nephritis development
Investigator(s):	Chan VSF, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Chan YK

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2010

List of Research Outputs

Kwok H.F., Zhang S.D., McCrudden C.M., Yuen H.F., Ting K.P., Wen Q., Khoo U.S. and Chan Y.K., Prognostic significance of minichromosome maintenance proteins in breast cancer, Am J Cancer Res. 2015, 5(1): 52-71.

Researcher : Chan YP

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.

Researcher : Chang T

List of Research Outputs

Law C.Y., Chang T., Cho S.Y., Yau E.K., Ng G.S., Fong N.C. and Lam C.W., Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy, Clinica Chimica Acta. 2015, 451: 292-296.

Researcher : Chen M

List of Research Outputs

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Researcher : Cheng YLB

List of Research Outputs

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Placental biology of Down Syndrome in relation to increased gene dosage
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	p53 related proteins and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	AMPK and metabolism in choriocarcinoma
Investigator(s):	Cheung ANY, Chan KK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	NANOG and chemoresistance of ovarian cancer-initiating cells
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2015

Project Title:	Nanog in ovarian cancer metabolism
Investigator(s):	Cheung ANY, Chan KK, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Molecular targets of Stem cell factor NANOG in stress responses of ovarian cancer
Investigator(s):	Cheung ANY, Wong GW, Chan KK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	19th International Congress of Cytology; Cervical cancer screening program in Hong Kong and China: Present and Future
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016
Completion Date:	06/2016

List of Research Outputs

Cheung A.N.Y., (1) Amniotic Fluid Embolism and (2) Application of Molecular Cytogenetics in Diagnosis of Gestational Trophoblastic Diseases, Invited speakers in the session on Gynaecological Pathology in the 21st Congress of Chinese Society of Pathology and 5th Annual Meeting of Chinese Pathologists 中华医学会病理学分会第二十一次学术会议暨第五届中国病理年会 , Kunming, Yunan, China, 5th – 8th November 2015. 2015.

Cheung A.N.Y., Cervical Cytology and HPV Testing in Preventing Cervical Cancer – Yin and Yang, Invited speaker organized by the Hong Kong Society of Cytology, 3rd March 2016. 2016.

Cheung A.N.Y., Gene Dosage and Phenotype in Down Syndrome, Department Seminar, Department of Pathology, The University of Hong Kong, 18th Feb 2016.. 2016.

Cheung A.N.Y., Genetics of Gestational Trophoblastic Diseases, Invited speaker in Hospital Authority commissioned training programme, 18th - 22nd Jan 2016, Queen Elizabeth Hospital and Prince of Wales Hospital, Hong Kong. 2016.

Cheung A.N.Y., HPV Testing and Cytology in Preventing Cervical Cancer – Yin and Yang, HPV檢測與細胞學防治宮頸癌 - 陰陽說, Invited speaker in The 2th Conference of Chinese Society for Colposcopy and Cervical Pathology, May 20-22, 2016. Beijing. 2016.

Cheung A.N.Y., Immunohistochemical and molecular adjunct techniques in differential diagnosis of molar lesions, Pathology. 2016, 46: S17-S18.

Cheung A.N.Y., Invited speaker on “Recent advances in cervical cytology and ancillary tests – application in cervical cancer screening” in Asia Oceania Research Organization on Genital Infections and Neoplasia Xinjiang Training Workshop 8th ‐9th August 2015. Urumqi. 2015.

Cheung A.N.Y., Microscope and DNA: A pathologist's perspective of GTD, Invited speaker HKU O & G 90th Anniversary Symposium, 14-15 November 2015. 2015.

Cheung A.N.Y., Updates on Classification of Ovarian Cancers - Clinicopathological and Genetic Features, Invited speakers in CME Meeting, Postgraduate Seminar, The Hong Kong College of Obstetricians and Gynaecologists, 8 November 2015. 2015.

Cheung A.N.Y., Updates on gynaecological pathology with reference to the 2014 WHO Classification of Tumours of Female Reproductive Organs, 妇科肿瘤病理更新－2014WHO女性生殖器官肿瘤分类, Invited speaker in the The Chinese Society of Gynecologic Oncology (CSGO) 15th Biennial meeting, Guangzhou on March 11-13, 2016. 2016.

Cheung M.F.F., Tong Y., Wang Y., Cheung A.N.Y., Liu Y., Lau K.H.K., Wong K.K.Y., Lo S.K. and Yuen K.Y., Epstein-Barr virus-positive T-cell-associated colitis mimicking inflammatory bowel disease: clinicopathological study of two cases, In: Cheung FM, Tong Y, Wang Y, Cheung AN, Liu Y, Lau KK, Wong KK, Lo SK, Yuen KY., Histopathology. 2015, 465-8.

Chu M.M.Y., Liu S., Tam K.F., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial Cancer., Int J Gynecol Pathol.. Wolters Kluwer, 2015, Sep;34(5):403-10..

Chu M.Y.M., Liu S., Tam K.F., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial Cancer, International Journal of Gynecological Pathology. 2015, 34: 403-410.

Ip P.C.P., Chow K.L., Wong K.W., Tse K.Y., Wong R.W.C., Chan A.N.H., Yuen N.W.F. and Cheung A.N.Y., Utility of Phosphohistone H3 in Uterine Smooth Muscle Tumors: An Outcome-Based Assessment, The United States and Canadian Academy of Pathology 105th Annual Meeting (Modern Pathology). Nature, 2016, 29: 272-316.

Leung T.H.Y., Tang W.M., Siu K.Y., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Enriched CD71(+) population by HPV-E6 protein exhibits cancer stem-like cells property and promotes radio-resistance in cervical cancer cells. , The 23rd World Congress on Controversies in Obstetrics, Gynecology & Infertility, 2016.

Leung T.H.Y., Tang W.M., Siu K.Y., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., HPV-E6 protein enriches CD55(+) population in cervical cancer cells which promotes radio-resistance and cancer aggressiveness., The 23rd World Congress on Controversies in Obstetrics, Gynecology & Infertility, 2016.

Li R.H.W., Liao S., Chiu C.N., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study, Reproductive Biology and Endocrinology. 2015, 13.

Lim D., Ip P.C.P., Cheung A.N.Y., Kiyokawa T. and Oliva E., Immunohistochemical Comparison of Ovarian and Uterine Endometrioid Carcinoma, Endometrioid Carcinoma With Clear Cell Change, and Clear Cell Carcinoma, The American Journal of Surgical Pathology. Wolters Kluwer, 2015, 39: 1061-1069.

Liu S., Wei N., Cheung A.N.Y. and Ngan H.Y.S., COMPARISON OF HIGH-RISK HUMAN PAPILLOMAVIRUS DETECTION BY APTIMA AND HYBRID CAPTURE 2 TESTS IN CERVICAL CYTOLOGY SPECIMENS , International Papillomavirus Conference. 2015.

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Ngu S.F., Chu M.Y.M., Tse K.Y., Chan K.K.L., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Malignant Ovarian Germ Cell Tumours: The Role of Lymphadenectomy and VAC Chemotherapy, The 4th Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO 2015), Seoul, Korea. 2015.

SO K.H., KOTTAWATTA K.S.A., KODITHUWAKKU KANKANAMGE S.P.K., Li R.H.W., Chiu C.N., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B. and Lee C.K.F., Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1, Fertil Steril. 2015, 104(2): 474-82.

Seto T.Y.M., Ip P.C.P., Ngu S.F., Cheung A.N.Y. and Pun T.C., Positive predictive value of endometrial polyps in Pipelle aspiration sampling: a histopathological study of 195 cases., Eur J Obstet Gynecol Reprod Biol.. 2016, 203: 12-15.

Siu K.Y., Kong D.S., Ngai S.Y., Chan H.Y., Jiang L., Wong E.S.Y., Liu S., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation., PLoS One. 2015, 10(7): e0133467.

Wong G.W. and Cheung A.N.Y., Stem cell transcription factor NANOG in cancers – is eternal youth a curse?, Expert Opinion on Therapeutic Targets. 2016, 20: 407-417.

Wong G.W., WONG T.L., Wong C.K., Tsun O.K.L. and Cheung A.N.Y., The miR-143 target TARDBP may serve as a marker for cervical cancer, 8th Annual Asian Oncology Summit. 2016.

Researcher : Cheung CH

List of Research Outputs

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Cheung MFF

List of Research Outputs

Cheung M.F.F., Tong Y., Wang Y., Cheung A.N.Y., Liu Y., Lau K.H.K., Wong K.K.Y., Lo S.K. and Yuen K.Y., Epstein-Barr virus-positive T-cell-associated colitis mimicking inflammatory bowel disease: clinicopathological study of two cases, In: Cheung FM, Tong Y, Wang Y, Cheung AN, Liu Y, Lau KK, Wong KK, Lo SK, Yuen KY., Histopathology. 2015, 465-8.

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.

Researcher : Cheung YN

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2010

Researcher : Ching HH

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	05/2016

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP, Chung SK
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The therapeutic potential of Polo-like protein kinase 4 in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Characterization of novel HBx regulated gene in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Researcher : Chiu KC

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Chiu YT

Project Title:	Analysis of hepatitis B virus genomic integration and characterization of its role in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL, Ho DWH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	10/2016

Project Title:	The significance of X-linked MID1 interacting protein 1 (MID1IP1) in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	11/2015

Project Title:	AACR Annual meeting 2016; The roles of x-linked Midline 1 interacting protein 1 (MID1IP1) in gender disparity and development of hepatocellular carcinoma
Investigator(s):	Chiu YT
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Chiu Y.T. and Ng I.O.L., Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor, Hong Kong Med J. 2016, 22(3 Suppl 4): 43-7.

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Chiu Y.T., The roles of x-linked Midline 1 interacting protein 1 (MID1IP1) in gender disparity and development of hepatocellular carcinoma, In: YT Chiu, IOL Ng, AACR Annual Meeting 2016.

Researcher : Choi WL

Project Title:	Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):	Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:	Pathology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	04/2011

Researcher : DENG J

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Researcher : Fan NY

List of Research Outputs

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Researcher : GONG C

List of Research Outputs

GONG C., MOK K.C., Man P.S., LAM E.W.F. and Khoo U.S., Translational regulation by eIF4E and its contribution to tamoxifen resistance in breast cancer, AACR Annual Meeting 2016, New Orleans . 2016.

Gong C., Yao S., Gomes A.R., Man P.S., Lee H.J., Gong G., Chang S., Kim S.B., Fujino K., Kim S.W., Park S.K., Lee J.W., Lee M.H., group K.S., Khoo U.S. and Lam E.W., BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer, Oncogenesis. 2016, 5: e214.

Karunarathna U., Kongsema M., Zona S., Gong C., Cabrera E., Gomes A.R., Man P.S., Khongkow P., Tsang J.W.H., Khoo U.S., Medema R.H., Freire R. and Lam E.W., OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance, Oncogene. 2015.

de Moraes G.N., Khongkow P., GONG C., Yao S., Gomes A.R., Kandola N., Delbue D., Man P.S., Khoo U.S., Ji Z., Sharrocks A. and Lam E.W., Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer. , Oncogenesis (In press). 2015.

Researcher : Gong C

List of Research Outputs

Researcher : Ho DWH

Project Title:	Investigation of functional synergism of CENPF and FOXM1 in hepatocellular carcinoma
Investigator(s):	Ho DWH, Ng IOL, Chan LK, Kai AKL, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Ho D.W.H., Kai A.K.L. and Ng I.O.L., TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma, Frontiers of Medicine. 2015.

Ho D.W.H., Sze M.F. and Ng I.O.L., Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability, Oncotarget. 2015.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Ho RSL

List of Research Outputs

Li L.F., Leung G.K.K., Ho R.S.L. and Lui W.M., Recurrent natural killer (NK)-cell lymphoma with central nervous system metastasis mimicking cerebellar infarction, World Neurosurgery. 2015, Epub on 2015-07-17.

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Huang F

Project Title:	Generation of dendritic cells from liver cancer cell-derived iPSc for novel tumor vaccine development - Part I: Reprogramming of liver cancer cells to pluripotency using non-viral plasmid vectors
Investigator(s):	Huang F
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2014

Project Title:	Mechanisms & therapeutic potential of interleukin-35 in systemic autoimmune & related lymphoproliferative disorders
Investigator(s):	Huang F
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	08/2015

List of Research Outputs

Huang F., Therapeutic Vaccination against Cancers - A Conceptual Overview with Updates on the Immunological Approach, In: Alexander Tsodikov, Vaccines and Vaccination Journal. Dover, USA, SMGroup, 2015, 1(2): 1009 - 1014.

Researcher : Ip HW

List of Research Outputs

Malherbe J.A., Fuller K.A., Mirzai B., Kavanagh S., So J.C.C., Ip H.W., Guo B.B., Forsyth C., Howman R. and Erber W.N., Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms, Journal of Clinical Pathology. 2016, jclinpath-2016-203625.

Singh G.H.H., Ip H.W., Li J., Yim R.L.H., Panagiotou I., Leung A.Y.H. and Kwong Y.L., Whole exome sequencing identifies novel mutations in relapsed or refractory acute promyelocytic leukaemia failing treatment with oral arsenic trioxide, 21st Congress of the European Hematology Association. Haematologica, 2016.

Researcher : Ip PCP

Project Title:	CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS
Investigator(s):	Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Annual Meeting of United States and Canadian Academy of Pathology; Utility of phosphohistone H3 in uterine smooth muscle tumors: An outcome-based assessment
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2016
Completion Date:	03/2016

Project Title:	Role of MAPK7 signaling in endometrial carcinomas
Investigator(s):	Ip PCP, Cheung ANY, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chu M.M.Y., Liu S., Tam K.F., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial Cancer., Int J Gynecol Pathol.. Wolters Kluwer, 2015, Sep;34(5):403-10..

Chu M.Y.M., Liu S., Tam K.F., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial Cancer, International Journal of Gynecological Pathology. 2015, 34: 403-410.

Ip P.C.P., New Bethesda System And WHO Histological Classification. Invited lecture at Family Planning Association, Hong Kong, 2015.

Ip P.C.P., Chow K.L., Wong K.W., Tse K.Y., Wong R.W.C., Chan A.N.H., Yuen N.W.F. and Cheung A.N.Y., Utility of Phosphohistone H3 in Uterine Smooth Muscle Tumors: An Outcome-Based Assessment, The United States and Canadian Academy of Pathology 105th Annual Meeting (Modern Pathology). Nature, 2016, 29: 272-316.

Ip P.C.P. and Tse K.Y., Vaginal Intraepithelial Neoplasia, In: Oluwole Fadare, Precancerous Lesions Of The Gynecologic Tract. Switzerland, Springer, 2015, 205-221.

Lim D., Ip P.C.P., Cheung A.N.Y., Kiyokawa T. and Oliva E., Immunohistochemical Comparison of Ovarian and Uterine Endometrioid Carcinoma, Endometrioid Carcinoma With Clear Cell Change, and Clear Cell Carcinoma, The American Journal of Surgical Pathology. Wolters Kluwer, 2015, 39: 1061-1069.

Ngu S.F., Chu M.Y.M., Tse K.Y., Chan K.K.L., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Malignant Ovarian Germ Cell Tumours: The Role of Lymphadenectomy and VAC Chemotherapy, The 4th Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO 2015), Seoul, Korea. 2015.

Ngu S.F., Chu M.Y.M., Tse K.Y., Chan K.K.L., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Treatment and Survival Outcomes in Women Treated with Malignant Ovarian Germ Cell Tumours, 19th International Meeting of The European Society of Gynaecological Oncology (ESGO 2015), Nice, France. 2015.

Seto T.Y.M., Ip P.C.P., Ngu S.F., Cheung A.N.Y. and Pun T.C., Positive predictive value of endometrial polyps in Pipelle aspiration sampling: a histopathological study of 195 cases., Eur J Obstet Gynecol Reprod Biol.. 2016, 203: 12-15.

Researcher : Ip PPC

Project Title:	CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS
Investigator(s):	Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Annual Meeting of United States and Canadian Academy of Pathology; Utility of phosphohistone H3 in uterine smooth muscle tumors: An outcome-based assessment
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2016
Completion Date:	03/2016

Project Title:	Role of MAPK7 signaling in endometrial carcinomas
Investigator(s):	Ip PCP, Cheung ANY, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Researcher : Kai AKL

Project Title:	The roles of chemokine C-C motif ligand 28 (CCL28) in hepatocarcinogenesis
Investigator(s):	Kai AKL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014
Completion Date:	08/2015

Project Title:	AACR annual meeting 2016; Downregulation of TIMP2 via HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma
Investigator(s):	Kai AKL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Ho D.W.H., Kai A.K.L. and Ng I.O.L., TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma, Frontiers of Medicine. 2015.

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):	Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Role of eIF4E in tamoxifen resistance in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals
Investigator(s):	Khoo US, Leung TW, Luk MY, Yeung MWR
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2013

Project Title:	The regulatory effect of a novel splice variant, BQ323636.1, on ERα transcriptional activity facilitates the development of tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Tang MKP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	The role of BQ, a novel splice variant of NCOR2 in the NRF2 antioxidant pathway
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	07/2015

Project Title:	Characterization of a Novel Splice Variant in Tamoxifen Resistant Breast Cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

Project Title:	Cardiac pacemaker channels modulating autophagy, cell senescence and apoptosis in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

List of Research Outputs

GONG C., MOK K.C., Man P.S., LAM E.W.F. and Khoo U.S., Translational regulation by eIF4E and its contribution to tamoxifen resistance in breast cancer, AACR Annual Meeting 2016, New Orleans . 2016.

Gong C., Yao S., Gomes A.R., Man P.S., Lee H.J., Gong G., Chang S., Kim S.B., Fujino K., Kim S.W., Park S.K., Lee J.W., Lee M.H., group K.S., Khoo U.S. and Lam E.W., BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer, Oncogenesis. 2016, 5: e214.

Karunarathna U., Kongsema M., Zona S., Gong C., Cabrera E., Gomes A.R., Man P.S., Khongkow P., Tsang J.W.H., Khoo U.S., Medema R.H., Freire R. and Lam E.W., OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance, Oncogene. 2015.

Khoo U.S., A Biomarker for Tamoxifen Resistant Breast Cancer, Hong Kong Pathology Forum 2016. 2016.

Khoo U.S., A Biomarker for Tamoxifen Resistant Breast Cancer, Pathology Forum 2016.

Khoo U.S., Croucher Senior Medical Research Fellowship , Croucher Foundation. 2015.

Kwok H.F., Zhang S.D., McCrudden C.M., Yuen H.F., Ting K.P., Wen Q., Khoo U.S. and Chan Y.K., Prognostic significance of minichromosome maintenance proteins in breast cancer, Am J Cancer Res. 2015, 5(1): 52-71.

Tang M.C., Soong I.S., Luk M.Y., Suen T.K., Hoie F., Man P.S., Tsun O.K.L. and Khoo U.S., Comparison of Fluorescence in situ hybridization (FISH) vs Dual-color in situ hybridization (DISH) for Assessment of HER2 gene amplification of breast cancer in Hong Kong. , Hong Kong Medical Journal (In press). . 2015.

de Moraes G.N., Khongkow P., GONG C., Yao S., Gomes A.R., Kandola N., Delbue D., Man P.S., Khoo U.S., Ji Z., Sharrocks A. and Lam E.W., Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer. , Oncogenesis (In press). 2015.

Researcher : Ko FCF

Project Title:	Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	The study of DLC1 regulates oxidative stress for tumor suppression
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	12/2015

List of Research Outputs

Ko F.C.F., Tai W.C.S. and Yam J.W.P., Study of DLC1 regulates oxidative stress for tutor suppression, The 25th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. 2016.

Mao X., Wong S.Y.S., Ko F.C.F. and Yam J.W.P., Functional role of caveolin-1-mediated S100P signaling in liver cancer metastasis under hypoxia., 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Ko F.C.F., Mao X. and Yam J.W.P., Clinical Relevance and Functional Role of Nuclear Met in Hepatocellular Carcinoma, The Liver Week 2016.

Researcher : Ko KH

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

Researcher : Koh HY

List of Research Outputs

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Kwok JSY

List of Research Outputs

Kwok J.S.Y., Leung E., Wong W., Leung K., Lee C.K., Lam W. and Ip P., Factors Influencing Hematopoietic Stem Cell Donation Intention in Hong Kong: A Web-Based Survey, Ann Transplant. 2015.

Researcher : LAW CT

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : LEUNG MH

List of Research Outputs

Kwok C.T.D., LEUNG M.H., Qin J., QIN Y., Wang J.J., Lee C.Y.L. and Yao K.M., The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells, Stem Cell Research. 2016.

Researcher : Lai JCC

Project Title:	Comparison of native influenza virus and virus-like-particles in their receptor-binding properties
Investigator(s):	Lai JCC, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Lai KH

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Lam CW

Project Title:	The first prospective second generation newborn screening in Hong Kong
Investigator(s):	Lam CW, Chan AYW, Mak CM
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Food
Investigator(s):	Lam CW, Wang M
Department:	Pathology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Undiagnosed diseases program for ending diagnostic odyssey
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2014

Project Title:	14th Human Proteome Organization World Congress (HUPO 2015) ; An Integrated NMR-MS Metabonomic Approach for Classification of Pleural Effusions: New Criteria
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

List of Research Outputs

Cho S.Y., Law C.Y., Ng K.L. and Lam C.W., Novel large deletion in AVPR2 gene causing copy number variation in a patient with X-linked nephrogenic diabetes insipidus, Clinica Chimica Acta. 2016, 455: 84-86.

Lam C.W., Law C.Y., Siu C.W.K., Fung C.W., Yau M.M., Huen K.F., Lee H.H.C. and Mak C.M., Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke, Clinica Chimica Acta. 2015, 448: 211-214.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Law C.Y., Chang T., Cho S.Y., Yau E.K., Ng G.S., Fong N.C. and Lam C.W., Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy, Clinica Chimica Acta. 2015, 451: 292-296.

Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tian X., Liang W.C., Feng Y., Wang J., Zhang V.W., Chou C.H., Huang H.D., Lam C.W., Hsu Y.Y., Lin T.S., Chen W.T., Wong L.J. and Jong Y.J., Expanding genotype/phenotype of neuromuscular diseases by comprehensive target capture/NGS, Neurology Genetics. 2015, 1: e14.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : Lau YT

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Law CT

List of Research Outputs

Researcher : Law CY

Project Title:	Lipoprotein subfraction profiling in pleural effusions
Investigator(s):	Law CY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2015
Completion Date:	11/2015

List of Research Outputs

Cho S.Y., Law C.Y., Ng K.L. and Lam C.W., Novel large deletion in AVPR2 gene causing copy number variation in a patient with X-linked nephrogenic diabetes insipidus, Clinica Chimica Acta. 2016, 455: 84-86.

Lam C.W., Law C.Y., Siu C.W.K., Fung C.W., Yau M.M., Huen K.F., Lee H.H.C. and Mak C.M., Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke, Clinica Chimica Acta. 2015, 448: 211-214.

Law C.Y., Chang T., Cho S.Y., Yau E.K., Ng G.S., Fong N.C. and Lam C.W., Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy, Clinica Chimica Acta. 2015, 451: 292-296.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : Lee CH

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Lee D

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Researcher : Lee HHC

List of Research Outputs

Lam C.W., Law C.Y., Siu C.W.K., Fung C.W., Yau M.M., Huen K.F., Lee H.H.C. and Mak C.M., Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke, Clinica Chimica Acta. 2015, 448: 211-214.

Researcher : Lee KW

Project Title:	The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma
Investigator(s):	Lee KW, Ng IOL, Ma SKY
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Hepatitis B virus promotes hepatocarcinogenesi through regulation of stemness factors
Investigator(s):	Lee KW, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	02/2016

Project Title:	Clinical relevance and characterization of CD47 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	02/2016

Project Title:	The role of cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	11/2015

Project Title:	The clinical relevance and role of cancer-associated fibroblast-derived HGF in the regulation of liver tumor-initiating cells
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014
Completion Date:	02/2016

Project Title:	The roles of Nuclear factor (erythroid-derived 2)-like 2 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	The clinical significance and functional characterization of Nuclear factor (erythroid-derived 2)-like 2 in regulating liver tumor initiating cells
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016
Completion Date:	02/2016

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Junior Investigator Award, International Liver Cancer Association Annual Conference 2015. 2015.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Top scored abstract, International Liver Cancer Association Annual Conference 2015. 2015.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Researcher : Lee MF

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Leung ON

Project Title:	Epigenetic modulation of Sox9 in HCC
Investigator(s):	Leung ON, Lo CLR
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Junior Investigator Award, International Liver Cancer Association Annual Conference 2015. 2015.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Top scored abstract, International Liver Cancer Association Annual Conference 2015. 2015.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

List of Research Outputs

Alexandrov L.B., Nik-Zainal S., Siu H.C., Leung S.Y. and Stratton M.R., A mutational signature in gastric cancer suggests therapeutic strategies, Nature Communications. 2015, 6: 8683.

Cavenee W...K..., Leung S.Y., Hawkins C..., Van Meir E...G..., Burger P...C... and Tabori U..., Turcot syndrome, In: Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Ellison D.W., Figarella-Branger D., Perry A., Reifenberger G., von Deimling A., WHO Classification of Tumours of the Central Nervous System, Revised. Fourth Edition. World Health Organization, 2016, 317.

Lee V.C.Y., Chow J.F.C., Lau E.Y.L., Kwong A., Leung S.Y., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Preimplantation genetic diagnosis for hereditary cancer syndrome: local experience, Hong Kong Medical Journal. 2016, 289-291.

Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Servier Inc., Paris, France, October 2015. 2015.

Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling of gastric cancer, The inaugural Molecular Analysis for Personalised therapy (MAP) conference, Paris, France, October 2015. 2015.

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Yuen S.T. and Leung S.Y., Genomics Study of Gastric Cancer and Its Molecular Subtypes, In: Marnix Jansen, Nicholas A. Wright, Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract. Springer International Publishing, 2016, 908: 419.

Researcher : Lin X

Project Title:	IMMUNOLOGY 2015™ AAI Annual Meeting; A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome
Investigator(s):	Lin X
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

List of Research Outputs

Rui K., Zhang Z., Tian J., Lin X., Wang X., Ma J., Tang X., Xu H., Lu L. and Wang S., Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis, Cellular and Molecular Immunology. 2016, 13: 401-408.

Researcher : Liu J

List of Research Outputs

Wong M.P., Liu J., Wang S. and Tin P.C., Calcium/caldmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma., AACR Annual Meeting 2016, New Orleans,U.S. 2016.

XIAO Z., Liu J., Tin P.C. and Wong M.P., The role of NFATc2 in regulating tumor initiating cell phenotype in non-small cell lung cancer. “New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures”, AACR,Shanghai. 2015.

Xiao Z., Liu J., Tin P.C. and Wong M.P., The Calcineurin/NFAT pathway mediates tumor initiating cell and drug resistance in lung cancer through SOX2 enhancer binding and ALDH upregulation, AACR Annual Meeting 2016. 2016.

Researcher : Lo CLR

Project Title:	Study of the downstream molecular mechanism of Sox9 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Study of the role of Stanniocalcin 1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	International Liver Cancer Association 9th Annual Conference; Sox9 regulates stem cell-like phenotypes and metastasis in hepatocellular carcinoma through Wnt/beta-catenin signaling
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

Project Title:	Study of the clinical relevance and functional role of Stanniocalcin 1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Epigenetic regulation of Cripto-1 expression in hepatocellular carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Wong C.L.T., Sharr W.W., Cheung T.T., Chan A.C.Y., Dai W.C., Sin S.L., Ng I.O.L., Lai C.L., Yuen R.M.F. and Lo C.M., Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone, Liver Transplantation. 2015, 21(12): 1504-10.

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Lo C.L.R., Distinguished Young Fellow, The Hong Kong Academy of Medicine. 2015.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Junior Investigator Award, International Liver Cancer Association Annual Conference 2015. 2015.

Lo C.L.R., Suriawinata A.A. and Rubin B., Liver metastasis of meningeal hemangiopericytoma: a study of 5 cases, Clinical and Molecular Hepatology. 2016.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Top scored abstract, International Liver Cancer Association Annual Conference 2015. 2015.

Xiong L., Teng L.L., Botelho M.G., Lo C.L.R., Lau S.K.P. and Woo P.C.Y., Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy, International Journal of Molecular Sciences. 2016, 17: 363.

Researcher : Lo J

List of Research Outputs

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Loong F

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Roles of leptin in regulating T cell function and autoimmune pathogenesis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Leptin regulates plasma cell generation and survival in autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	B-1 cell response and its regulation during influenza virus infection
Investigator(s):	Lu L, Ko KH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

Project Title:	Outstanding Researcher Award 2012-13
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2014

Project Title:	The role of B1 cells in the pathogenesis of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	The Role of B cells in the pathogenesis of experimental Sjögren’s syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015
Completion Date:	12/2015

Project Title:	Role of B cells in the pulmonary anti-viral immune response
Investigator(s):	Lu L, Ma K
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Major Research Project
Start Date:	01/2015

Project Title:	The role of B1 cells in the development of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Functional characterization and therapeutic application of regulatory B cells in Sjögren’s syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	The Role of B cells in the development of experimental Sjogren's syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Studies on the Pathogenesis and Treatment of Sjören’s Syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Croucher Foundation - Research Grants
Start Date:	01/2016

Project Title:	2016 Keystone Symposia Conference: B Cells at the Intersection of Innate and Adaptive Immunity ; A critical role of IL-17 in regulating B-1 cell differentiation during influenza infection
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016
Completion Date:	06/2016

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Ma J., Feng D., Wei Y., Tian J., Tang X., Rui K., Lu L., Xu H. and Wang S., Blockade of Glucocorticoid-Induced Tumor Necrosis Factor–Receptor-Related Protein Signaling Ameliorates Murine Collagen-Induced Arthritis by Modulating Follicular Helper T Cells, The American Journal of Pathology. 2016, 186: 1559-1567.

Peng H., Liu Y., Tian J., Ma J., Tang X., Rui K., Tian X., Mao C., Lu L., Xu H., Jiang P. and Wang S., The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto’s Thyroiditis, Scientific Reports. 2015, 5: 17702.

Rui K., Zhang Z., Tian J., Lin X., Wang X., Ma J., Tang X., Xu H., Lu L. and Wang S., Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis, Cellular and Molecular Immunology. 2016, 13: 401-408.

Tang X., Tian J., Ma J., Wang J., Qi C., Rui K., Wang Y., Xu H., Lu L. and Wang S., GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis, Oncotarget. 2016, 7: 8590-8600.

Tian J., Rui K., Tang X., Wang W., Ma J., Tian X., Wang Y., Xu H., Lu L. and Wang S., IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis, Oncotarget. 2016.

Tian J., Rui K., Tang X., Ma J., Wang Y., Tian X., Zhang Y., Xu H., Lu L. and Wang S., MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1., J Immunol. 2015, 195: 1301-1311.

Tian X., Tian J., Tang X., Rui K., Zhang Y., Ma J., Wang Y., Xu H., Lu L. and Wang S., Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression, OncoImmunology. 2015, 4: e1038687.

Wang J., Peng H., Tian J., Ma J., Tang X., Rui K., Tian X., Wang Y., Chen J., Lu L., Xu H. and Wang S., Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome, Immunologic Research. 2016, 64: 489-496.

Wang W., Zhang Y., Zhu B., Duan T., Xu Q., Wang R., Lu L. and Jiao Z., Plasma microRNA expression profiles in Chinese patients with rheumatoid arthritis, Oncotarget. 2015, 6: 42557-42568.

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

Wang Y., Tian J., Tang X., Rui K., Tian X., Ma J., Ma B., Xu H., Lu L. and Wang S., Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice, Oncotarget. 2016, 7(13): 15356=15368.

Researcher : Lu P

List of Research Outputs

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Lui WC

List of Research Outputs

YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015.

Researcher : MA KF

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : MOK KC

List of Research Outputs

GONG C., MOK K.C., Man P.S., LAM E.W.F. and Khoo U.S., Translational regulation by eIF4E and its contribution to tamoxifen resistance in breast cancer, AACR Annual Meeting 2016, New Orleans . 2016.

Researcher : Ma K

List of Research Outputs

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

Researcher : Ma KF

List of Research Outputs

Researcher : Ma SKY

Project Title:	Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):	Ma SKY, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	10/2016

Project Title:	Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):	Ma SKY, Chan KW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	08/2015

Project Title:	Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2015

Project Title:	PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):	Ma SKY, Guan X, Lo CM, Man K
Department:	Anatomy
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	05/2016

Researcher : Ma W

List of Research Outputs

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Researcher : Mak CM

List of Research Outputs

Lam C.W., Law C.Y., Siu C.W.K., Fung C.W., Yau M.M., Huen K.F., Lee H.H.C. and Mak C.M., Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke, Clinica Chimica Acta. 2015, 448: 211-214.

Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142.

Researcher : Mak CY

List of Research Outputs

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Researcher : Man HY

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Man PS

List of Research Outputs

GONG C., MOK K.C., Man P.S., LAM E.W.F. and Khoo U.S., Translational regulation by eIF4E and its contribution to tamoxifen resistance in breast cancer, AACR Annual Meeting 2016, New Orleans . 2016.

Gong C., Yao S., Gomes A.R., Man P.S., Lee H.J., Gong G., Chang S., Kim S.B., Fujino K., Kim S.W., Park S.K., Lee J.W., Lee M.H., group K.S., Khoo U.S. and Lam E.W., BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer, Oncogenesis. 2016, 5: e214.

Karunarathna U., Kongsema M., Zona S., Gong C., Cabrera E., Gomes A.R., Man P.S., Khongkow P., Tsang J.W.H., Khoo U.S., Medema R.H., Freire R. and Lam E.W., OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance, Oncogene. 2015.

Tang M.C., Soong I.S., Luk M.Y., Suen T.K., Hoie F., Man P.S., Tsun O.K.L. and Khoo U.S., Comparison of Fluorescence in situ hybridization (FISH) vs Dual-color in situ hybridization (DISH) for Assessment of HER2 gene amplification of breast cancer in Hong Kong. , Hong Kong Medical Journal (In press). . 2015.

de Moraes G.N., Khongkow P., GONG C., Yao S., Gomes A.R., Kandola N., Delbue D., Man P.S., Khoo U.S., Ji Z., Sharrocks A. and Lam E.W., Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer. , Oncogenesis (In press). 2015.

Researcher : Mao X

Project Title:	The role of mitochondria-targeted Heme Oxygenase-1 in liver cancer development and progression
Investigator(s):	Mao X, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

Mao X., Wong S.Y.S., Ko F.C.F. and Yam J.W.P., Functional role of caveolin-1-mediated S100P signaling in liver cancer metastasis under hypoxia., 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Ko F.C.F., Mao X. and Yam J.W.P., Clinical Relevance and Functional Role of Nuclear Met in Hepatocellular Carcinoma, The Liver Week 2016.

Tey S.K., Mao X. and Yam J.W.P., Exosomes released from nuclear Met expressing HCC cells promote metastasis and formation of lung premetastatic niche, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Nuclear Met regulates liver cancer metastasis via NF-κB/MMP2 pathway, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Role of nuclear Met-derived exosomes in hepatocellular carcinoma metastasis and lung premetastatic niche formation, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL, Tung KK
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2011

Project Title:	Cancer Biology
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Croucher Summer Courses
Start Date:	08/2013

Project Title:	The role of Lgr5 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Delineation of the role of RSK2 and their natural mutants in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Delineation of the role of RPS6KA3, which encodes p90 ribosomal S6 kinase 2 (RPS6KA3), and their natural mutants in liver cancer
Investigator(s):	Ng IOL, Chan LK, Chiu YT, Ho DWH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Characterization of functions of RhoE/ROCK pathway in regulating chemoresistance of liver cancer
Investigator(s):	Ng IOL, Ma W
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL, Wong CCL, Cui C
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Characterization of anti-CCL28 as a novel therapy to overcome sorafenib resistance in HCC
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Role of RalA and RalGAP in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Ching H.H., Lau Y.T., Ling P.M., Lee M.F., Ma K.F., Cheng Y.L.B., Lo C.L.R., Ng I.O.L. and Lee K.W., Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis, Oncotarget. 2015, 6(41): 43483-95.

Chiu Y.T. and Ng I.O.L., Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor, Hong Kong Med J. 2016, 22(3 Suppl 4): 43-7.

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Wong C.L.T., Sharr W.W., Cheung T.T., Chan A.C.Y., Dai W.C., Sin S.L., Ng I.O.L., Lai C.L., Yuen R.M.F. and Lo C.M., Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone, Liver Transplantation. 2015, 21(12): 1504-10.

Garnelo M., Tan A., Her Z., Yeong J., Lim C.J., Chen J., Lim K.H., Weber A., Chow P., Chung A., Ooi L.L., Toh H.C., Heikenwalder M., Ng I.O.L., Nardin A., Chen Q., Abastado J.P. and Chew V., Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma, Gut. 2015.

Ho D.W.H., Kai A.K.L. and Ng I.O.L., TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma, Frontiers of Medicine. 2015.

Ho D.W.H., Sze M.F. and Ng I.O.L., Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability, Oncotarget. 2015.

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89.

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Ng I.O.L., Asian Journal of Surgery. 2015.

Ng I.O.L., Gastroenterology (International Consultant), 2016.

Ng I.O.L., Genes and Cancer, 2015.

Ng I.O.L., Hepatocellular carcinoma - molecular pathogenesis, cell signaling, and cancer stem cells, Asian Pacific Primary Liver Cancer Expert (APPLE) Meeting, Osaka. 2015.

Ng I.O.L., Hepatocellular carcinoma - molecular pathogenesis, cell signaling, and cancer stem cells, The World Academy of Science Annual Meeting, Vienna. 2015.

Ng I.O.L., Journal of Gastroenterology and Hepatology. 2015.

Ng I.O.L., Journal of Hepatocellular Carcinoma (Editorial Board). 2015.

Ng I.O.L., Liver Cancer. 2015.

Ng I.O.L., Oncogenesis (Nature Partner Journal), 2016.

Ng I.O.L., State-of-the-Art Lecture: ‘Fibrosis-dependent Mechanism of Hepatocarcinogenesis’, Asian Pacific Association for the Study of Liver Single Topic Conference 2016, Busan, Korea. 2016.

RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.

RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016.

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.C.L., Wong C.M. and Ng I.O.L., Hormonal control of the metabolic machinery of hepatocellular carcinoma, Hepatobiliary Surg Nutr. 2016, 5(3): 195-7.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Ng RK

Project Title:	The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia
Investigator(s):	Ng RK, Yiu SM, Chan LC
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Dysregulation of DNA methylation in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	Biochemistry
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	The role of BMI-1 in regulation of JAK-STAT signaling pathway in human leukemia
Investigator(s):	Ng RK, Yiu SM
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Epigenetic regulation of enhancer RNA in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2015.

Researcher : Ngan HYS

Project Title:	High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer
Investigator(s):	Ngan HYS, Wong RLC
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1994

Project Title:	Clinical significance and application of HPV-related microRNAs in cervical pre-maglinant lesions and cancer
Investigator(s):	Ngan HYS, Liu S, Ng EKO, Cheung ANY, Chan KKL, Kwong A
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	08/2016

Project Title:	Roles of HPV-E6 protein and CD55(+) population in regulating radio-resistance in cervical cancer cells
Investigator(s):	Ngan HYS, Chan KKL, Leung THY, Cheung ANY
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	Functional characterization of subpopulation cells expressing transferrin receptor (CD71) and the roles of HPV viral protein in cervical cancer
Investigator(s):	Ngan HYS, Leung THY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014
Completion Date:	11/2015

Project Title:	Functional characterization of CD71(+) population and the roles of HPV-E6 protein in cervical cancer
Investigator(s):	Ngan HYS, Chan KKL, Cheung ANY, Leung THY, Siu KY
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Elucidating the potential role of CD109 as a cancer stem-like cell marker in cervical cancer
Investigator(s):	Ngan HYS, Leung THY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015
Completion Date:	09/2016

Project Title:	Investigation on the oncogenic roles of HPV-E6 and mCRPs in cervical cancer cells
Investigator(s):	Ngan HYS, Leung THY, Siu KY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

List of Research Outputs

Su H., Tiwari A.F.Y., Ngan H.Y.S., Yip Y.L., Cheung A., Tsao G.S.W. and Deng W., Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression, Oncotarget. 2016.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Molecular determinants of H9N2 virus haemagglutinin and neuraminidase affecting virus tropism for the human and swine respiratory tract
Investigator(s):	Nicholls JM, Chan WY, Mok KP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	Sialoglyco 2014; Glycomic Characterization of Respiratory Tract Tissues of Ferrets Shows Expression of Different Sialylatyed Glycans to Humans: Implications for the Use of Ferrets in Influenza Virus Infection Studies.
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014

Project Title:	Modulation of MERS-CoV infection of the human ex vivo respiratory tract by the use of interferon, cyclophilin inhibitors and blocking antibody therapy
Investigator(s):	Nicholls JM, Chan WY
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	The viral genetic determinants of influenza H5N1 virus in causing acute lung injury - an in vitro study
Investigator(s):	Nicholls JM, Chan MCW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2015

List of Research Outputs

Chan M.C.W., Kuok I.T., Leung C.Y.H., Hui P.Y., Doak S.A., Lau E.H.Y., Nicholls J.M., Fang X., Guan Y., Lee J.W., Chan W.Y., Webster R.G., Matthay M.A. and Peiris J.S.M., Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo, Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(13): 3621-6.

Chan W.Y., Chan L.Y., Mok K.P., Tao K.P., Chan M.C.W., Peiris J.S.M. and Nicholls J.M., Risk assessment of human infection by H9 influenza viruses using an explant system, Pathology. 2016, 48 Suppl 1: S105.

Fan L.Y., Doak S.A., Wong K.S.C., Li O.T.W., Nicholls J.M., Rabadan R., Peiris J.S.M. and Poon L.L.M., Generation of live attenuated influenza virus by using codon usage bias, Journal of Virology. 2015, 89: 10762-73.

Hui P.Y., Li H.S., Cheung M.C., Chan W.Y., Yuen K.M., Mok K.P., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3, Scientific Reports. 2016, 6: 28593.

Liu W., WONG K.L., He Q.M., Wong H.M.E., Tang S.M., ZHANG R., So M.T., Wong K.K.Y., Nicholls J.M., Cherny S.S., Sham P.C., Tam P.K.H., Garcia-Barcelo M.M. and Xia H.M., Chinese family with diffuse oesophageal leiomyomatosis: a new COL4A5/COL4A6 deletion and a case of gonosomal mosaicism, BMC Medical Genetics. 2015, 16(1): 49.

Wang Z., Nicholls J.M., Liu F., Wang J., Feng Z., Liu D., Sun Y., Zhou C., Li Y., Li H., Qi S., Huang X., Sui J., Liao Q., Peiris J.S.M., Yu H. and Wang Y., Pulmonary and central nervous system pathology in fatal cases of hand foot and mouth disease caused by enterovirus A71 infection, Pathology. 2016, 48(3): 267-74.

ZHANG R., Yu J.K., PENG J., Wang F.H., Liu H.Y., Lui V.C.H., Nicholls J.M., Tam P.K.H., Lamb J.R., Chen Y. and Xia H.M., Role of CD56-expressing immature biliary epithelial cells in biliary atresia, World Journal of Gastroenterology. 2016, 22(8): 2545-2557.

Researcher : Shek TWH

List of Research Outputs

Lang H.H.B., Shek T.W.H. and Wan K.Y., Does microscopically involved margin increase disease recurrence after curative surgery in papillary thyroid carcinoma?, Journal of Surgical Oncology. 2016, Epub ahead of print: n/a-n/a.

Lang H.H.B., Shek T.W.H. and Wan K.Y., Impact of microscopic extra-nodal extension (ENE) on locoregional recurrence following curative surgery for papillary thyroid carcinoma, Journal of Surgical Oncology. 2016, Epub ahead of print.

Lau K.S., Lam K.O., Choy T.S., Shek T.W.H., Chung L.P. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer and predicted pattern of metastases, In: Annals of Oncology, European Society of Medical Oncology Asia 2015 Congress. 2015, 26(suppl 9): ix46.

Researcher : Siu CWK

List of Research Outputs

Lam C.W., Law C.Y., Siu C.W.K., Fung C.W., Yau M.M., Huen K.F., Lee H.H.C. and Mak C.M., Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke, Clinica Chimica Acta. 2015, 448: 211-214.

Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142.

Researcher : Siu HC

List of Research Outputs

Alexandrov L.B., Nik-Zainal S., Siu H.C., Leung S.Y. and Stratton M.R., A mutational signature in gastric cancer suggests therapeutic strategies, Nature Communications. 2015, 6: 8683.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

Researcher : So JCC

Project Title:	Determination of the eaxct copy number variation in alpha globin genes and investigation of its effect on the phenotype of beta thalassaemia intermedia
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	06/2016

List of Research Outputs

Green A.S., Maciel T.T., Hospital M.A., Yin C., Mazed F., Townsend E.C., Pilorge S., Lambert M., Paubelle E., Jacquel A., Zylbersztejn F., Decroocq J., Poulain L., Sujobert P., Jacque N., Adam K., So J.C.C., Kosmider O., Auberger P., Hermine O., Weinstock D.M., Lacombe C., Mayeux P., Vanasse G.J., Leung A.Y.H., Moura I.C., Bouscary D. and Tamburini J., Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia, Science Advances. 2015, 1: e1500221-e1500221.

Malherbe J.A., Fuller K.A., Mirzai B., Kavanagh S., So J.C.C., Ip H.W., Guo B.B., Forsyth C., Howman R. and Erber W.N., Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms, Journal of Clinical Pathology. 2016, jclinpath-2016-203625.

So J.C.C., Epidemiology, diagnosis and prevention of thalassaemias in Hong Kong and Mainland China, XXXVI World Congress International Society of Hematology, Glasgow, United Kingdom, 19 April 2016. 2016.

So J.C.C., Hospital Authority Corporate Scholarship for Conventional Cytogenetics & Molecular Genetics for Inherited Disease, 2016-17, Hospital Authority. 2016.

So J.C.C., How would you like to test for alpha thalassaemia?, Seminar of The Hong Kong Association of Blood Transfusion and Haematology, Hong Kong, 17 June 2016. 2016.

So J.C.C., Where have all the thalassaemias gone?, Indian Ocean Rim Laboratory Haematology Congress 2015, Perth, Australia, 16 October 2015. 2015.

Surapolchai P., Sirachainan N., So J.C.C., Hongeng S., Pakakasama S., Anurathapan U. and Chuansumrit A., Curative Stem Cell Transplantation for Severe Hb H Disease Manifesting From Early Infancy: Phenotypic and Genotypic Analyses, Hemoglobin. 2016, 40: 70-73.

Researcher : So TY

List of Research Outputs

Lo J., Lau Y.T., So T.Y., Lu P., Chan V.S.F., Cheung C.H., Ching H.H., Cheng Y.L.B., Ma K.F., Ng I.O.L. and Lee K.W., Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma, Liver Int. 2015.

Researcher : Srivastava G

Project Title:	Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Ondrejka S.L., Moffitt A.B., Tse E.W.C., Hsi E.D., Goodlad J.R., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Gascoyne R.D., Rajagopalan D., Love C. and Dave S., Whole Exome Sequencing of Type 1 and Type 2 Enteropathy-Associated T Cell Lymphoma Reveals Genetic Basis of Eatl Oncogenesis, 57th American Society of Hematology Annual Meeting. American Society of Hematology, 2015, 126: 575.

Researcher : Sze MF

Project Title:	The characterizations of Ubiquitin-Conjugating Enzyme E2O (UBE2O) in mitotic checkpoint control via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

List of Research Outputs

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Ho D.W.H., Sze M.F. and Ng I.O.L., Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability, Oncotarget. 2015.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Tam S

List of Research Outputs

CHAU H.W.D., NG K., Chan S.Y.T., Cheng Y.Y., Fong B., Tam S., Kwong Y.L. and Tse E.W.C., Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9, Journal of Hematology & Oncology. 2015, 8.

Ko K.Y.J., Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Ho P.C. and Ng E.H.Y., Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome, Gynecological Endocrinology. 2016, 32: 390-394.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Best Poster Presentation Award (Clinical), HKU O&G 90th Anniversary Celebration. 2015.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Oral glucose tolerance test should be recommended as the screening method for dysglycaemia in all Southern Chinese women with polycystic ovary syndrome., The XXI FIGO World Congress of Gynecology and Obstetrics. 2015.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome, Human Reproduction. 2015, 30: 2178-2183.

Researcher : Tey SK

List of Research Outputs

Tey S.K., Ko F.C.F., Mao X. and Yam J.W.P., Clinical Relevance and Functional Role of Nuclear Met in Hepatocellular Carcinoma, The Liver Week 2016.

Tey S.K., Mao X. and Yam J.W.P., Exosomes released from nuclear Met expressing HCC cells promote metastasis and formation of lung premetastatic niche, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Nuclear Met regulates liver cancer metastasis via NF-κB/MMP2 pathway, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Role of nuclear Met-derived exosomes in hepatocellular carcinoma metastasis and lung premetastatic niche formation, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Tey S.K., Travel Award, The Liver Week 2016. 2016.

Researcher : Tin PC

List of Research Outputs

Leung E., Fan X.X., Wong M.P., Jiang Z.H., Liu Z.Q., Yao X.J., Lu L.L., Zhou Y.L., Yau L.F., Tin P.C. and Liu L., Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation , Antioxidants & Redox Signaling. 2016, 24: 263-279.

Wong M.P., Liu J., Wang S. and Tin P.C., Calcium/caldmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma., AACR Annual Meeting 2016, New Orleans,U.S. 2016.

XIAO Z., Liu J., Tin P.C. and Wong M.P., The role of NFATc2 in regulating tumor initiating cell phenotype in non-small cell lung cancer. “New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures”, AACR,Shanghai. 2015.

Xiao Z., Liu J., Tin P.C. and Wong M.P., The Calcineurin/NFAT pathway mediates tumor initiating cell and drug resistance in lung cancer through SOX2 enhancer binding and ALDH upregulation, AACR Annual Meeting 2016. 2016.

Researcher : Tong Y

List of Research Outputs

Cheung M.F.F., Tong Y., Wang Y., Cheung A.N.Y., Liu Y., Lau K.H.K., Wong K.K.Y., Lo S.K. and Yuen K.Y., Epstein-Barr virus-positive T-cell-associated colitis mimicking inflammatory bowel disease: clinicopathological study of two cases, In: Cheung FM, Tong Y, Wang Y, Cheung AN, Liu Y, Lau KK, Wong KK, Lo SK, Yuen KY., Histopathology. 2015, 465-8.

Researcher : Trendell-Smith NJ

List of Research Outputs

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Researcher : Tsang FH

Project Title:	Functional characterization of Chromobox protein homolog 1 (CBX1) and delineation of its regulation by micro-RNA in hepatocellular carcinoma
Investigator(s):	Tsang FH, Wong CM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

List of Research Outputs

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Tsang F.H., Travel Award for Asian Pacific Association for the Study of the Liver Single Topic Conference, Asian Pacific Association for the Study of the Liver. 2016.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Tsang FH

List of Research Outputs

Tsang F.H., Travel Award for Asian Pacific Association for the Study of the Liver Single Topic Conference, Asian Pacific Association for the Study of the Liver. 2016.

Researcher : Tse PW

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Tsui WY

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Tsun OKL

List of Research Outputs

Tang M.C., Soong I.S., Luk M.Y., Suen T.K., Hoie F., Man P.S., Tsun O.K.L. and Khoo U.S., Comparison of Fluorescence in situ hybridization (FISH) vs Dual-color in situ hybridization (DISH) for Assessment of HER2 gene amplification of breast cancer in Hong Kong. , Hong Kong Medical Journal (In press). . 2015.

Wong G.W., WONG T.L., Wong C.K., Tsun O.K.L. and Cheung A.N.Y., The miR-143 target TARDBP may serve as a marker for cervical cancer, 8th Annual Asian Oncology Summit. 2016.

Researcher : WANG X

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

Researcher : WONG TL

List of Research Outputs

Wong G.W., WONG T.L., Wong C.K., Tsun O.K.L. and Cheung A.N.Y., The miR-143 target TARDBP may serve as a marker for cervical cancer, 8th Annual Asian Oncology Summit. 2016.

Researcher : Wang J

List of Research Outputs

Wang Z., Nicholls J.M., Liu F., Wang J., Feng Z., Liu D., Sun Y., Zhou C., Li Y., Li H., Qi S., Huang X., Sui J., Liao Q., Peiris J.S.M., Yu H. and Wang Y., Pulmonary and central nervous system pathology in fatal cases of hand foot and mouth disease caused by enterovirus A71 infection, Pathology. 2016, 48(3): 267-74.

Researcher : Wang X

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Researcher : Wang Y

List of Research Outputs

Cheung M.F.F., Tong Y., Wang Y., Cheung A.N.Y., Liu Y., Lau K.H.K., Wong K.K.Y., Lo S.K. and Yuen K.Y., Epstein-Barr virus-positive T-cell-associated colitis mimicking inflammatory bowel disease: clinicopathological study of two cases, In: Cheung FM, Tong Y, Wang Y, Cheung AN, Liu Y, Lau KK, Wong KK, Lo SK, Yuen KY., Histopathology. 2015, 465-8.

Researcher : Wei L

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Researcher : Wei L

List of Research Outputs

Researcher : Wong CCL

Project Title:	The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2013

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	American Association for Cancer Research Annual Meeting 2016; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 reduces oxidative stress to promote hepatocellular carcinoma
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.C.L., Wong C.M. and Ng I.O.L., Hormonal control of the metabolic machinery of hepatocellular carcinoma, Hepatobiliary Surg Nutr. 2016, 5(3): 195-7.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Wong CL

Project Title:	The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2013

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	American Association for Cancer Research Annual Meeting 2016; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 reduces oxidative stress to promote hepatocellular carcinoma
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

List of Research Outputs

Researcher : Wong CM

Project Title:	Deregulation of SETDB1 and its functional roles in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Functional and pathological characterizations of chromatin remodeling protein HELLS in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Expression and pathological roles of linc-CHD1L-1, a novel long non-coding RNA in liver cancer
Investigator(s):	Wong CM, Tsang FH
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Clinicopathological significance and functional roles of G9a up-regulation in Hepatocellular Carcinoma
Investigator(s):	Wong CM, Wong CCL, Tsang FH
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	The roles of RNA N6-Adensoine methylation in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL, Tsang FH
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	American Association for Cancer Research Annual Meeting 2016 ; Delineating the pathological roles and molecular functions of histone methyltransferase G9a in hepatocellular carcinoma
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Chiu Y.T., Wong K.L., Choi S.W., Sze M.F., Ho D.W.H., Chan L.K., Lee M.F., Man K., Cherny S.S., Yang W., Wong C.M., Sham P.C. and Ng I.O.L., Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma, Journal of Hepatology. 2016, 64(6): 1256-64.

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Ma W., Sze M.F., Chan L.K., Lee M.F., Wei L., Wong C.M., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma., In: Andrei V. Gudkov and Mikhail V. Blagosklonny , Oncotarget. Impact Journals, 2016, 7: 41445-41459.

Tsang F.H., Au L.K.S., Wei L., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility., In: S. Chen; B. Yang; X. Chen, Frontiers of medicine. China, Higher Education Press, Springer, 2015, 9: pp 331–343.

Wong C.C.L., Wong C.M. and Ng I.O.L., Hormonal control of the metabolic machinery of hepatocellular carcinoma, Hepatobiliary Surg Nutr. 2016, 5(3): 195-7.

Wong C.M., Wei L., LAW C.T., Ho D.W.H., Tsang F.H., Au L.K.S., Sze M.F., Lee M.F., Wong C.C.L. and Ng I.O.L., Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology. 2016, 63: 474-487.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Wong ESY

List of Research Outputs

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Siu K.Y., Kong D.S., Ngai S.Y., Chan H.Y., Jiang L., Wong E.S.Y., Liu S., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation., PLoS One. 2015, 10(7): e0133467.

Researcher : Wong GW

Project Title:	Cellular functions and potential clinical application of miR-143 in cervical cancer
Investigator(s):	Wong GW, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

Project Title:	Identification of HNF-1β direct targets in ovarian clear cell carcinoma
Investigator(s):	Wong GW, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Wong G.W. and Cheung A.N.Y., Stem cell transcription factor NANOG in cancers – is eternal youth a curse?, Expert Opinion on Therapeutic Targets. 2016, 20: 407-417.

Wong G.W., WONG T.L., Wong C.K., Tsun O.K.L. and Cheung A.N.Y., The miR-143 target TARDBP may serve as a marker for cervical cancer, 8th Annual Asian Oncology Summit. 2016.

Researcher : Wong KW

List of Research Outputs

Ip P.C.P., Chow K.L., Wong K.W., Tse K.Y., Wong R.W.C., Chan A.N.H., Yuen N.W.F. and Cheung A.N.Y., Utility of Phosphohistone H3 in Uterine Smooth Muscle Tumors: An Outcome-Based Assessment, The United States and Canadian Academy of Pathology 105th Annual Meeting (Modern Pathology). Nature, 2016, 29: 272-316.

Researcher : Wong KY

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer
Investigator(s):	Wong MP, Liu J
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014
Completion Date:	08/2015

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Cancer Genomics; Application of whole exome sequencing in metachronous lung cancer evaluation
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015
Completion Date:	07/2015

Project Title:	Regulation of SOX2 expression by NFATc2 in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	06/2016

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Annual Scientific Meeting of the American Association for Cancer Research 2016; Calcium/calmodulin‐dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti‐cancer drugs in lung adenocarcinoma
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

Project Title:	The role and mechanisms of Ca2+/calmodulin-dependent protein kinase II, subunit A (CaMK2A) in SOX2 upregulation in tumor initiating cells and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

List of Research Outputs

Researcher : Wong MLY

List of Research Outputs

Au Yeung K.H.R., Guo T., Chen W.Y.W., Wong K.Y., Wong M.L.Y., Chan Y.P., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Imbalanced expression of a and b isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma, The 105th Annual Meeting of the Japanese Society of Pathology. 第105回日本病理学会総会, Japan, The Japanese Society of Pathology, 2016, 105: 287.

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer
Investigator(s):	Wong MP, Liu J
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014
Completion Date:	08/2015

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Cancer Genomics; Application of whole exome sequencing in metachronous lung cancer evaluation
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015
Completion Date:	07/2015

Project Title:	Regulation of SOX2 expression by NFATc2 in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	06/2016

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Annual Scientific Meeting of the American Association for Cancer Research 2016; Calcium/calmodulin‐dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti‐cancer drugs in lung adenocarcinoma
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

Project Title:	The role and mechanisms of Ca2+/calmodulin-dependent protein kinase II, subunit A (CaMK2A) in SOX2 upregulation in tumor initiating cells and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

List of Research Outputs

Chan H.Y., Tsoi A., Wong M.P., Ho J.C.M. and Lee E.Y.P., Utility of 18F-FDG PET/CT in the assessment of lymphoepithelioma-like carcinoma, Nuclear Medicine Communications. 2016, 37(5): 437-45.

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Lee V.H.F., Wang J.J., Xu J., Sihoe D.L.A. and Wong M.P., Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia, International Journal of Cancer. 2015, 137: 311-319.

Leung E., Fan X.X., Wong M.P., Jiang Z.H., Liu Z.Q., Yao X.J., Lu L.L., Zhou Y.L., Yau L.F., Tin P.C. and Liu L., Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation , Antioxidants & Redox Signaling. 2016, 24: 263-279.

Li M.J., Liu Z., Wang P., Wong M.P., Nelson M., Kocher J.P.A., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J., GWASdb v2: an update database for human genetic variants identified by genome-wide association studies, Nucleic Acids Research. 2016, 44: D869-D876.

Ma L., Wang D.D., Huang Y., Yan H., Wong M.P. and Lee V.H.F., EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib, BMC Bioinformatics. 2015, 16.

Machieta M.J., Zhou W., Karlins E., Sampson J.N., Freedman N.D., Yang Q., Hicks B., Dagnall C., Hautman C., Jacobs K.B., Abnet C.C., Aldrich M.C., Amos C., Amundadottir L.T., Arslan A.A., Beane-Freeman L.E., Berndt S.I., Black A., Blot W.J., Bock C.H., Bracci P.M., Brinton L.A., Bueno-de-Mesquita H.B., Burdett L., Buring J.E., Butler M.A., Canzian F., Canrreon T., Chatterjee K.G., Chang I.S., Chatterjee N., Chen C., Chen C., Chen K., Chung C.C., Cook L.S., Crous Bou M.A.R.T.A., Cullen M., Davis F.G., De Vivo I., Ding T., Doherty J., Duell E., Epstein C.G., Fan J.H., Figueroa J.D., Fraumemi J.F., Friedenreich C.M., Fuchs C.S., Gallinger S., Gao Y.T., Gapstur S.M., Garcia-Closas M., Gaudet M.M., Gaziano J.M., Giles G.G., Gilanders E.M., Giovannucci E.L., Goldin L., Goldstein A.M., Haiman C.A., Hallmans G.O.R.A.N., Hankinson S.E., Harris C.C., Henriksson R., Holly E.A., Hong Y.C., Hoover R.N., Hsiung C.A., Hu N., Hu W., Hunter D.J., Hutchinson A., Jenab M., Johansen C., Khaw K.T., Kim H.N., Kim Y.H., Kim Y.T., Klein A.P., Klein R., Koh W.P., Kolonel L.N., Kooperberg C., Kraft P., Krogh V., Kurtz R.C., LaCroix A., Lan Q., Landi M.T., Marchand L.L., Li D., Liang X., Liao L.M., Lin D., Liu J., Lissowska J., Lu L., Magliocco A., Malats N., Matsuo K., McNeill L.H., McWilliams R.R., Mirabello L., Moore L., Olson S.H., Orlow I., Park J.Y., Patiño-Garcia A., Peplonska B., Peters U., Peterson G.M., Pooler L., Prescott J., Prokunina-Olsson L., Purdue M.P., Qiao Y.L., Rajaraman P., Real F.X., Riboli H.A., Risch H.A., Rodriguez-Santiago B., Ruder A.M., Savage S.A., Schumacher F., Schwartz A.G., Schwartz K.L., Seow A., Wendy Setiawan V., Severi G., Shen H., Sheng X., Shin M., Shu O., Silverman D., Spitz Z.M., Stevens V., Stolzenberg-Solomon R., Stram D., Tang Z., Taylor P., Teras L., Tobias D., Van Den Berg D., Visvanathan K., Wacholder S., Wang J., Wang Z., Wentzensen N., Wheeler W., White E., Wiencke J., Wolpin B., Wong M.P., Wu C., Wu T., Wu X., Wu Y.L., Wunder J.S., Xia L., Yang H.P., Yang P.C., Yu K., Zanetti K.A., Zeleniuch-Jacquotte A., Zheng W., Zhou B., Ziegler, R.G., Perez-Jurado L.A., Caporaso N.E., Rothman N., Tucker M., Dean M. and Yeager M., Chanock S., Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome, Nature Communications. 2016, 7: 11843.

Sampson J.N., Wheeler W.A., Yeager M., Panagiotou O., Wang Z., Berndt S.I., Lan Q., Abnet C.C., Amundadottir L.T., Sihoe D.L.A. and Wong M.P., Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types, Journal of the National Cancer Institute. 2015, Epub on 2015-10-12.

Wang Z., Seow W.J., Shiraishi K., Hsiung C.A., Matsuo K., Liu J., Chen K., Yamji T., Yang Y., Sihoe D.L.A. and Wong M.P., Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women, Human Molecular Genetics. 2016, 25(3): 620-629.

Wong M.P., Liu J., Wang S. and Tin P.C., Calcium/caldmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma., AACR Annual Meeting 2016, New Orleans,U.S. 2016.

XIAO Z., Liu J., Tin P.C. and Wong M.P., The role of NFATc2 in regulating tumor initiating cell phenotype in non-small cell lung cancer. “New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures”, AACR,Shanghai. 2015.

Xiao Z., Liu J., Tin P.C. and Wong M.P., The Calcineurin/NFAT pathway mediates tumor initiating cell and drug resistance in lung cancer through SOX2 enhancer binding and ALDH upregulation, AACR Annual Meeting 2016. 2016.

Zhu Y., Qin J., Wong M.P. and Wang J.J., The role of FOXM1 and Kaiso in Non-small-cell lung carcinoma (NSCLC), The 23rd Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and the 12th Annual European Conference on Computational Biology (ECCB), Dublin, Ireland, 10-14 July 2015.. 2015.

Researcher : Wong WC

List of Research Outputs

Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ng W.Y., Wong W.C., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling, The American Journal of Pathology. 2015, 185(7): 2038-2048.

Researcher : XIAO F

List of Research Outputs

DENG J., WANG X., CHEN Q., Sun X., XIAO F., Ko K.H., Zhang M. and Lu L., B1a cells play a pathogenic role in the development of autoimmune arthritis, Oncotarget. 2016, 12: 19299-19311.

Researcher : XIAO Z

List of Research Outputs

XIAO Z., Liu J., Tin P.C. and Wong M.P., The role of NFATc2 in regulating tumor initiating cell phenotype in non-small cell lung cancer. “New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures”, AACR,Shanghai. 2015.

Xiao Z., Liu J., Tin P.C. and Wong M.P., The Calcineurin/NFAT pathway mediates tumor initiating cell and drug resistance in lung cancer through SOX2 enhancer binding and ALDH upregulation, AACR Annual Meeting 2016. 2016.

Researcher : Xiao Z

List of Research Outputs

Researcher : Xu M

List of Research Outputs

Lai K.H., Xu M., Chiu K.C., Tse P.W., Wei L., Law C.T., Lee D., Wong C.M., Wong M.P., Ng I.O.L. and Wong C.C.L., NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma, Clin Cancer Res. 2016, 22(12): 3105-17.

Xu M., Lai K.H., Lin S.H., Tse P.W., Chiu K.C., Koh H.Y., Law C.T., Wong C.M., Cai Z., Wong C.C.L. and Ng I.O.L., Transketolase counteracts oxidative stress to drive cancer development, Proc Natl Acad Sci U S A. 2016, 113(6): E725-34.

Researcher : Yam JWP

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	Clinical relevance and functions of nuclear Met in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	The functional role of phospho-DLC1S549-mediatd galectin-1 in liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Functional role and clinical significance of galectin-1 in liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Molecular interaction of Cav1 and S100P in liver cancer metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Functional role of hypoxia-induced caveolin-1 in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	Functional role of caveolin-1-mediated S100P in liver cancer metastasis under hypoxic stress
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	25th Asian Pacific Association for the Study of the Liver (APASL 2016); Nuclear Met-derived exosomes promote HCC metastasis and formation of lung premetastatic niche
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2016
Completion Date:	02/2016

Project Title:	Functional role of exosomes in liver cancer metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Ko F.C.F., Tai W.C.S. and Yam J.W.P., Study of DLC1 regulates oxidative stress for tutor suppression, The 25th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL), February 20-24, 2016, Tokyo, Japan. 2016.

Mao X., Wong S.Y.S., Ko F.C.F. and Yam J.W.P., Functional role of caveolin-1-mediated S100P signaling in liver cancer metastasis under hypoxia., 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Ko F.C.F., Mao X. and Yam J.W.P., Clinical Relevance and Functional Role of Nuclear Met in Hepatocellular Carcinoma, The Liver Week 2016.

Tey S.K., Mao X. and Yam J.W.P., Exosomes released from nuclear Met expressing HCC cells promote metastasis and formation of lung premetastatic niche, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Nuclear Met regulates liver cancer metastasis via NF-κB/MMP2 pathway, 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016). 2016.

Tey S.K., Mao X. and Yam J.W.P., Role of nuclear Met-derived exosomes in hepatocellular carcinoma metastasis and lung premetastatic niche formation, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Yam J.W.P., Advances in Hepatology . 2015.

Yam J.W.P., Journal of Liver: Disease & Transplantation . 2015.

Yam J.W.P., PLoS ONE, Public Libraray of Science. 2015.

Researcher : Yan HHN

Project Title:	Regulation of stromal miR125b on normal colonic epithelial cell renewal and tumorigenesis
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Intestinal organoid cultures of early onset colorectal cancers
Investigator(s):	Yan HHN, Leung SY, Law WL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

Researcher : Yue SKS

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Researcher : Yuen ST

List of Research Outputs

Yan H.H.N., Lai J.C.C., Ho R.S.L., Leung W.K., Law W.L., Lee J.F., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., Yue S.K.S., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation, Gut. 2016, Epub on 2016-06-21.

Yuen S.T. and Leung S.Y., Genomics Study of Gastric Cancer and Its Molecular Subtypes, In: Marnix Jansen, Nicholas A. Wright, Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract. Springer International Publishing, 2016, 908: 419.

Researcher : Zhao F

Project Title:	Role of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in breast cancer tumorigenesis
Investigator(s):	Zhao F, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

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