Dept of Microbiology

DEPT OF MICROBIOLOGY

Researcher : AHMED SS

List of Research Outputs

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Researcher : CHENG Z

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Researcher : CHEUNG YY

List of Research Outputs

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Researcher : CHOI KY

List of Research Outputs

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Yip C.Y., Cheng V.C.C. and Yuen K.Y., Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease, Journal of Infection. 2016, 72: 507-524.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Researcher : Cai J

List of Research Outputs

Chan J.F.W., Chan K.H., Cai J., Tsang K.L., Markovitz D.M. and Yuen K.Y., BanLec Inhibits Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by Binding with the S1 Subunit of the Viral Spike Glycoprotein, 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Researcher : Chan CS

List of Research Outputs

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Chan JFW

Project Title:	Epidemiology, seroprevalence, and clinical manifestations of immunodeficiency due to autoantibody against interferon gamma in Hong Kong
Investigator(s):	Chan JFW, Hung FNI
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	01/2014
Completion Date:	09/2016

Project Title:	Incidence and clinical significance of Atopobium vaginae bacteremia in Hong Kong.
Investigator(s):	Chan JFW, Teng LL
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2014

Project Title:	American Society for Virology - 2016 Annual Meeting; Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction
Investigator(s):	Chan JFW
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	06/2016

Project Title:	Characterization and determination of animal reservoirs of a novel animal flavivirus.
Investigator(s):	Chan JFW, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., An atypical case of invasive fungal infection in an apparently immunocompetent patient: an emerging problem in Asia, 2nd Asia Continuous Antifungal Research and Education (CARE) Forum, Taipei, Taiwan. 2015.

Chan J.F.W., Chan K.H., Cai J., Tsang K.L., Markovitz D.M. and Yuen K.Y., BanLec Inhibits Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by Binding with the S1 Subunit of the Viral Spike Glycoprotein, 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., TSANG C.C., Yang J., Xing F., Leung S.M., Ngan A.H.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Trichomonascus (Candida) ciferrii isolates associated with granular myringitis, European Congress of Clinical Microbiology and Infectious Diseases, ECCMID 2016.

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Chan J.F.W., Tee K.M., Choi G.K.Y., Zhu Z., Poon W.S.R. and Yuen K.Y., Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction, 35th Annual Meeting of the American Society for Virology (ASV 2016), American Society for Virology. 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Invasive fungal infections in Asia, The 4th Invasive Fungal Infection Expert Multidisciplinary Symposium (IFIEMS 2016), Haikou, Hainan, China. 2016.

Chan J.F.W., Management of Neutropenic and Post-transplant Patients: What A&E Physicians Should Know, The Global Emergency Medicine Meeting 2015, HKU-Shenzhen Hospital, Shenzhen, China. 2015.

Chan J.F.W., Outbreak investigation of hospital-acquired infection: is your hospital safe?, Shenzhen Medical Association Hospital Infection Control Committee Annual Scientific Meeting (2015), Shenzhen, China. 2015.

Chan J.F.W., Practical Management of Invasive Fungal Disease in the Hematology Unit: A Focus on Treatment, 3rd Asia Continuing Antifungal Research & Education (CARE) Forum, Singapore. 2016.

Chan J.F.W., Chan K.H., Yeung M.L., To K.K.W., Markovitz D.M. and Yuen K.Y., Rediscovery of Banana Lectin (BanLec) as a Pan-coronavirus Antiviral: In Vitro & Ex Vivo evidence, 55th Interscience Conference on Antimicrobial Agents and Chemotherapy / 28th International Congress of Chemotherapy and Infection (ICAAC/ICC 2015). 2015.

Chan J.F.W., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients., Emerging Microbes And Infections. 2016, 5: e19.

Chan J.F.W., Top 1% scholar (2015), Thomas Reuters Essential Science Indicators . 2015.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chan J.F.W., Update on Clinical Management, Laboratory Diagnosis and Infection Control of Zika Virus Infection, Ad Hoc Clinical Infection & Public Health Forum: An Update on Zika Virus Centre for Health Protection ICB / Hospital Authority IDCTC, Hong Kong. 2016.

Chan J.F.W., Update on Zika Virus Infection, 29th Scientific Committee on Vector-Borne Diseases Meeting, Centre for Health Protection, Hong Kong. 2016.

Chan J.F.W., Tee K.M., Choi G.K.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Urinary shedding pattern of polyomaviruses in patients with ketamine uropathy, 34th Annual Meeting of the American Society for Virology (ASV 2015), American Society for Virology. 2015.

Chan J.F.W., CHOI K.Y., Yip C.Y., Cheng V.C.C. and Yuen K.Y., Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease, Journal of Infection. 2016, 72: 507-524.

Cheng V.C.C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Viral Infections, an Overview with a Focus on Prevention of Transmission, Reference Module in Biomedical Sciences. Elsevier Inc., 2015.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Lau S.K.P., Chan J.F.W., TSANG C.C., Chan S.M., Ho M.L., Que T.L., Lau Y.L. and Woo P.C.Y., Human oropharynx as natural reservoir of Streptobacillus hongkongensis, Scientific Reports. 2016, 6: 24419.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

Sridhar S., Fung K.S., Chan J.F.W., Lam J.Y., Yip E.K., Hung F.N.I., Wu A.K., Que T.L., Lau S.K.P. and Woo P.C.Y., High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study., BMC Infectious Diseases. 2016, 16: 74.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

To K.K.W., Zhou J., Chan J.F.W. and Yuen K.Y., Host genes and influenza pathogenesis in humans: an emerging paradigm, Current Opinion in Virology. 2015, 14: 7-15.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Zhao Y., Chan J.F.W., TSANG C.C., Wang H., Guo D., Pan Y., Xiao Y., Yue N., Chen J.H.K., Lau S.K.P., Xu Y. and Woo P.C.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study , Journal of Clinical Microbiology. 2015, 53: 3639-3645.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Zumla A., Chan J.F.W., Azhar E.I., Hui D.S. and Yuen K.Y., Coronaviruses — drug discovery and therapeutic options, Nature Reviews Drug Discovery. 2016, 15: 327-347.

Researcher : Chan KCW

List of Research Outputs

Leung C.C., Chan K.C.W., Yam W.C., Lee M.P., Chan C.K., Wong K.H., Ho P.L., Mak I. and Tam C.M., Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong, Respirology. 2016.

Researcher : Chan KH

Project Title:	18th Annual Meeting ESCV 9th-12th September 2015 Edinburgh; Detection of influenza C virus infection in hospitalized children in Hong Kong by real-time PCR
Investigator(s):	Chan KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

List of Research Outputs

Chan J.F.W., Chan K.H., Cai J., Tsang K.L., Markovitz D.M. and Yuen K.Y., BanLec Inhibits Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by Binding with the S1 Subunit of the Viral Spike Glycoprotein, 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan K.H., Yeung M.L., To K.K.W., Markovitz D.M. and Yuen K.Y., Rediscovery of Banana Lectin (BanLec) as a Pan-coronavirus Antiviral: In Vitro & Ex Vivo evidence, 55th Interscience Conference on Antimicrobial Agents and Chemotherapy / 28th International Congress of Chemotherapy and Infection (ICAAC/ICC 2015). 2015.

Cheung D.H., TSANG K.L., Fang J., Xu J., Chan K.H., Ip D.K.M., Peiris J.S.M., Leung G.M. and Cowling B.J., Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses, Journal of Infectious Diseases. 2015, 212(3): 391-6.

Chiu S.S.S., Feng S., Chan K.H., Lo J.Y., Chan L.Y., So L.Y., Cowling B.J. and Peiris J.S.M., Hospital-based vaccine effectiveness against influenza B lineages, Hong Kong, 2009−14, Vaccine. 2016, 34(19): 2164-9.

Cowling B.J., Kwan Y.W., Wong S.C., Feng S., Leung C.W., Chan L.Y., Chan K.H., Ng T.K., To W.K., Peiris J.S.M. and Chiu S.S.S., Interim estimates of the effectiveness of influenza vaccination against influenza-associated hospitalization in children in Hong Kong, 2015-16, Influenza and Other Respiratory Viruses. 2016.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Ip D.K.M., Lau L.L., Chan K.H., Fang J., Leung G.M., Peiris J.S.M. and Cowling B.J., The dynamic relationship between clinical symptomatology and viral shedding In naturally acquired seasonal and pandemic influenza virus infections, Clinical Infectious Diseases. 2015, 62(4): 431-7.

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Tsang K.L., Fang J., Chan K.H., Ip D.K.M., Leung G.M., Peiris J.S.M., Cowling B.J. and Cauchemez S.T., Individual correlates of infectivity of influenza A Virus infections in households, PLoS One. 2016, 11: e0154418.

Tsang K.L., Cauchemez S.T., Fang J., Chan K.H., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Individual correlates of infectivity of influenza virus infections in households, The Hong Kong College of Community Medicine Annual Scientific Meeting, Hong Kong, 19 September 2015.. 2015.

Tsang K.L., Cowling B.J., Fang J., Chan K.H., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cauchemez S.T., Influenza A virus shedding and infectivity in households, Journal of Infectious Diseases. 2015, 212: 1420-1428.

WANG X., Yang L., Chan K.H., Chan K.P., CAO P., Lau E.H.Y., Peiris J.S.M. and Wong C.M., Age and Sex Differences in Rates of Influenza-Associated Hospitalizations in Hong Kong, American Journal of Epidemiology. 2015, 182(4): 335-44.

Wei L., Chan K.H., Ip D.K.M., Fang J., Fung R.O.P., Leung G.M., Peiris J.S.M. and Cowling B.J., Burden, seasonal pattern, and symptomatology of acute respiratory illnesses of different viral etiology in children presenting at outpatient clinics in Hong Kong. , Clinical Microbiology and Infection . 2015, 21(9): 861-6.

Xu C., Chan K.H., Tsang K.L., Fang J., Fung R.O.P., Ip D.K.M., Cauchemez S.T., Leung G.M., Peiris J.S.M. and Cowling B.J., Comparative epidemiology of influenza B Yamagata- and Victoria-lineage viruses in households, American Journal of Epidemiology. 2015, 182: 705-713.

Xu C., Perera R.A.P.M., Chan K.H., Fang J., Ip D.K.M., Ng S., Leung G.M., Peiris J.S.M. and Cowling B.J., Effect of serum 25-hydroxyitamin Don influenza infection in Hong Kong, The Hong Kong College of Community Medicine Annual Scientific Meeting, Hong Kong, 19 September 2015.. 2015.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Chan SF

List of Research Outputs

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Researcher : Chen H

Project Title:	Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	07/2004

Project Title:	Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Antiviral drug resistance in H5N1 virus
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2007

Project Title:	The role of RAP55 and P-bodies in the regulation of influenza virus replication
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Adaptive strategies of the H7N9 virus PB2 polymerase for replication in humans
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

List of Research Outputs

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

Chen H., Development and Application of Replication Competent DelNS1 Life Attenuated Influenza Virus as Universal Vaccines for Emerging Influenza and Other Respiratory Viruses, Grand Challenges Annual Meeting 2015, October 18-21, 2015, Beijing, China. 2015.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

VERHOEVEN R.J.A., TONG S., Zhang G.H. and Chen H., Regulation and functions of Epstein-Barr virus encoded miRNA and non-coding RNA in nasopharyngeal carcinoma, AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicine, December 4-7, 2015 in Boston, MA, USA. 2015.

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

XIANG Z., Liu Y., Zheng J., GAO Y., LU A., Lam K.T., Chen H., Tsao G.S.W., Chan G.C.F., Lau Y.L. and Tu W., Faculty Outstanding Research Output Award., Faculty of Medicine, the University of Hong Kong. 2015.

XIANG Z., Liu Y., Zheng J., Lam K.T., GAO Y., Chan G.C.F., Chen H., Tsao G.S.W., Lau Y.L. and Tu W., Faculty Outstanding Research Output Award, Faculty of Medicine, the University of Hong Kong. 2015.

Xu L.L., Bao L.L., Lau S.Y., Wu W.L., Yuan J., Gu S.Z., Li F.D., Lv Q., Xu Y.F., Pushko P., Chen H. and Qin C., Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice, VACCINE. UK, ELSEVIER SCI LTD, 2016, 34: 2627-2633.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Chen HKJ

Project Title:	Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):	Chen HKJ, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2009

List of Research Outputs

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Siu G.K.H., Chen H.K.J., Ng T.K., Lee R.A., Fung K.S.C., To W.C.S., Wong B.K.C., Cheung S., Wong I.W.F., Tam M.M.P., Lee S.S.W. and Yam W.C., Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong, PLOS ONE. 2015, 10: e0139728.

Researcher : Chen JHK

Project Title:	Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):	Chen HKJ, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2009

List of Research Outputs

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Zhao Y., Chan J.F.W., TSANG C.C., Wang H., Guo D., Pan Y., Xiao Y., Yue N., Chen J.H.K., Lau S.K.P., Xu Y. and Woo P.C.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study , Journal of Clinical Microbiology. 2015, 53: 3639-3645.

Researcher : Chen M

Project Title:	Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):	Chen M, Zheng B
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Researcher : Chen Z

Project Title:	A novel model for the study of lung pathogenesis of SARS
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	08/2007

Project Title:	Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	China AIDS Initiative - General Award
Start Date:	05/2008

Project Title:	Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Global Health Grants
Start Date:	10/2008

Project Title:	Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	05/2011

Project Title:	A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2011

Project Title:	AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2011

Project Title:	Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):	Chen Z, Liu L
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV.
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2012

Project Title:	Mechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity
Investigator(s):	Chen Z, Liu L
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	12/2015

Project Title:	Novel Secretory Immunoadhesins for HIV Prevention
Investigator(s):	Chen Z, Cheung KLA
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	06/2016

Project Title:	To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):	Chen Z, Liu L, Cheung KW, Du DY
Department:	Microbiology
Source(s) of Funding:	Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:	07/2013

Project Title:	Further optimization of live viral vector for HIV vaccine research
Investigator(s):	Chen Z, Wang H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):	Chen Z, Liu L, Cheung KW, Du DY
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2013

Project Title:	Mechanism of potentiating HIV antigen-specific CD8+ T cells
Investigator(s):	Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2014

Project Title:	A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):	Chen Z, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	12/2014

Project Title:	Role of a newly identified PD-1 isoform in modulating immune responses
Investigator(s):	Chen Z, Cheung KLA
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):	Chen Z, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2015

Project Title:	A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	04/2015

Project Title:	Role of Δ42PD1 in HIV Infection
Investigator(s):	Chen Z, Cheung KLA
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention
Investigator(s):	Chen Z, Man K
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	09/2015

Project Title:	Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Investigator(s):	Chen Z, Cheung KLA, Tan Z
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

List of Research Outputs

Chen Z., 陳志偉, 郭佳, 安明暉, 王輝 / 單基因編碼的雙或多價特異性抗HIV免疫粘附素 Chinese patent no. ZI, 2014 1 0245945. X, 2015.

Cheung K.W., Peng Q., He L., Cai K., Jiang Q., Zhou B., To W.C.S., Yam W.C., Liu L., Chen Z., Wang H. and Tee K.K., Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System, PLOS ONE. 2016, 11: e0153641.

Cong Z., Xue J., Xiong J., Yao N., Wang W., Jiang H., Chen T., Chen Z., Wei Q. and Qin C., Correlation of central memory CD4+ T-Cell decrease in the peripheral blood with disease progression in SIVmac251-infected Chinese rhesus macaques , Journal of Medical Primatology. 2015, 44: 175-182.

TANG J., Yam W.C. and Chen Z., Mycobacterium tuberculosis infection and vaccine development, Tuberculosis. 2016, 98: 30-41.

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Cheng VCC

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Tee K.M., Choi G.K.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Urinary shedding pattern of polyomaviruses in patients with ketamine uropathy, 34th Annual Meeting of the American Society for Virology (ASV 2015), American Society for Virology. 2015.

Chan J.F.W., CHOI K.Y., Yip C.Y., Cheng V.C.C. and Yuen K.Y., Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease, Journal of Infection. 2016, 72: 507-524.

Chan T.C., Cheng V.C.C., Hung I.F.N., Chan F.H.W., Ng W.C. and Yuen K.Y., The Association Between Methicillin Resistant Staphylococcus aureus Colonization and Mortality in Chinese Nursing Home Older Adults: A 2-Year Prospective Cohort, Journal of the American Medical Directors Association. 2015, 16: 796-797.

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Cheng V.C.C., Chau P.H., So S.Y.C., Chen J.H.K., Poon R.W.S., Wong S.C.Y., Hung I.F.N., Lee W.M., Tai J.W.M., Ho P.L., Yam W.C. and Yuen K.Y., Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1381-1386.

Cheng V.C.C., Chau P.H., Lee W.M., Ho S.K.Y., Lee D.W.Y., So S.Y.C., Wong S.C.Y., Tai J.W.M. and Yuen K.Y., Hand-touch contact assessment of high-touch and mutual-touch surfaces among healthcare workers, patients, and visitors, Journal of Hospital Infection. 2015, 90: 220-225.

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Cheng V.C.C., Tai J.W.M., Li W.S., Chau P.H., So S.Y.C., Wong L.M.W., Ching R.H.C., Ng M.M.L., Ho S.K.Y., Lee D.W.Y., Lee W.M., Wong S.C.Y. and Yuen K.Y., Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong, American Journal of Infection Control. 2016, 44: 621-624.

Cheng V.C.C., Lee W.M., Sridhar S., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong, Journal of Hospital Infection. 2015, 90: 355-356.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Cheng V.C.C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Viral Infections, an Overview with a Focus on Prevention of Transmission, Reference Module in Biomedical Sciences. Elsevier Inc., 2015.

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Mok M.Y., Cheng V.C.C., Lui S.L., Kwan P.Y.L., Chan G.C.W., Yap Y.H.D., Chan D.T.M. and Lo W.K., Severe liver failure due to influenza A infection in a hemodialysis patient, Hemodialysis international. 2016, 20(1): E16-18.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Cheng Z

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Researcher : Cheung KLA

Project Title:	Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells
Investigator(s):	Cheung KLA, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013
Completion Date:	08/2016

Project Title:	Transfer of HIV-1 from HIV-1 latently infected CD34+ hematopoietic progenitors to CD4+ T cells
Investigator(s):	Cheung KLA, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2014

Project Title:	Downstream signaling pathways involved in Δ42PD1 cytokine induction
Investigator(s):	Cheung KLA, Chen Z
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	05/2016

Project Title:	Characterising the role of a novel PD1 isoform expressed on gamma-delta T cells in HIV-1 infection
Investigator(s):	Cheung KLA, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

List of Research Outputs

Cheung K.L.A., Conference Scholarship, 21st International AIDS Conference. 2016.

Cheung K.L.A., Young Investigator Award, Hong Kong Society for Immunology Annual General Meeting and Scientific Meeting. 2015.

Researcher : Cheung KW

Project Title:	Type of cell death and related mechanisms for gut homing CD4 T cells during human immunodeficiency virus-1 (HIV-1) infection
Investigator(s):	Cheung KW, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

Project Title:	Role of microvesicles released by HIV-1 infected gut homing CD4 T cells in AIDS pathogenesis
Investigator(s):	Cheung KW, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014
Completion Date:	11/2015

List of Research Outputs

Cheung K.W., Peng Q., He L., Cai K., Jiang Q., Zhou B., To W.C.S., Yam W.C., Liu L., Chen Z., Wang H. and Tee K.K., Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System, PLOS ONE. 2016, 11: e0153641.

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Cheung NN

List of Research Outputs

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

Researcher : Chow KH

List of Research Outputs

Ho P.L., Lai E.L.Y. and Chow K.H., Carriage of meticillin-susceptible and -resistant Staphylococcus aureus by medical students in Hong Kong, Journal of Hospital Infection. 2015.

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : Chow WN

List of Research Outputs

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Researcher : Chu H

Project Title:	Investigating the outcome of MERS-CoV infection in human peripheral blood mononuclear cells.
Investigator(s):	Chu H, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014

Project Title:	Exploring the potential involvement of human macrophage and dendritic cells in the pathogenesis Zika virus
Investigator(s):	Chu H, Zhou J
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Curreem SOT

List of Research Outputs

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Researcher : Ding SY

List of Research Outputs

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Researcher : Fan YY

List of Research Outputs

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Researcher : Gao P

List of Research Outputs

Hu J., WONG N.K., LU M., Chen X., YE S., Zhao Q., Gao P., Kao R.Y.T., Shen J. and Yang D., HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay, Chem. Sci.. 2016, 7: 2094-2099.

Researcher : Guan Y

Project Title:	Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	04/2002

Project Title:	Searching for the precursor of SARS-Cov in Southern China
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Partner State Key Laboratory of Emerging Infectious Diseases
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	Matching Fund for State Key Laboratory (SKL)
Start Date:	02/2009

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	01/2013

Project Title:	Active influenza surveillance in poultry and humans focused on Guangdong and Zhejiang Provinces
Investigator(s):	Guan Y, Zhu H
Department:	School of Public Health
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	06/2014
Completion Date:	03/2016

Project Title:	Outstanding Researcher Award 2013-14
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2014

Researcher : HO CH

List of Research Outputs

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015.

Researcher : HUANG X

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Ho PL

Project Title:	A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):	Ho PL, Yuen KY, Que TL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

Project Title:	Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):	Ho PL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Project Title:	Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):	Ho PL, Hung CT
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):	Ho PL, Wong SSY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):	Ho PL, Yam WC, Leung CC, Yew WW, Mok YWT, Chan KS, Tam CM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006

Project Title:	Syndromic Surveillance and Modeling for Infectious Diseases
Investigator(s):	Ho PL, Wu JTK
Department:	Microbiology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources
Investigator(s):	Ho PL, Lo WU
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	Development and validation of a MALDI-TOF based rapid test for detection of emerging carbapenem resistance in Bacteroides fragilis
Investigator(s):	Ho PL, Lo WU
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Unveiling the characteristics of emerging Staphylococcus lugdunensis sequence type 3 clone by genomics analysis
Investigator(s):	Ho PL, Sham PC, Lo WU
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Cheng V.C.C., Chau P.H., So S.Y.C., Chen J.H.K., Poon R.W.S., Wong S.C.Y., Hung I.F.N., Lee W.M., Tai J.W.M., Ho P.L., Yam W.C. and Yuen K.Y., Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1381-1386.

Cheng V.C.C., Chen J.H.K., Ng W.C., Wong J.Y.H., Chow M.K., Law T.C., So S.Y.C., Wong S.C.Y., Chan T.C., Chan F.H.W., Ho P.L. and Yuen K.Y., Emergence of Carbapenem-Resistant Acinetobacter baumannii in Nursing Homes With High Background Rates of MRSA Colonization, Infection Control & Hospital Epidemiology. 2016, 1-4.

Cheng V.C.C., Lee W.M., Sridhar S., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong, Journal of Hospital Infection. 2015, 90: 355-356.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Cheong K.N., Chiu S.S.S., Chan B.W., To K.K.W., Chan L.Y. and Ho P.L., Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure, Journal of Microbiology, Immunology and Infection. 2016, 49: 127-130.

Ho P.L., Lai E.L.Y. and Chow K.H., Carriage of meticillin-susceptible and -resistant Staphylococcus aureus by medical students in Hong Kong, Journal of Hospital Infection. 2015.

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Lam T.P., Lam K.F., Ho P.L. and Yung W.H.R., Knowledge, attitude, and behaviour toward antibiotics among Hong Kong people: local-born versus immigrants, Hong Kong Medical Journal. 2015, 21 Suppl 7: 41-47.

Leung C.C., Chan K.C.W., Yam W.C., Lee M.P., Chan C.K., Wong K.H., Ho P.L., Mak I. and Tam C.M., Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong, Respirology. 2016.

Researcher : Ho TY

List of Research Outputs

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Researcher : Huang Y

List of Research Outputs

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Researcher : Hung FNI

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Researcher : Im SWK

Project Title:	Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):	Im SWK, Yam WC
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Researcher : Jia L

List of Research Outputs

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Kao RYT

Project Title:	Mode of action of a lead anti-influenza compound identified by chemical genetics
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2006

Project Title:	Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2007

Project Title:	Direct binding of influenza A nuceloprotein (NP) to a novel NP nuclear export inhibitor
Investigator(s):	Kao RYT, Sze KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	ASM Microbes 2016; Identification and mechanistic study of a novel compound suppressing the expression of multiple virulence genes in Staphylococcus aureus
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016

List of Research Outputs

CHOI C.K., Ho D.N.Y., Hui K.F., Kao R.Y.T. and Chiang A.K.S., Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies, PLOS ONE. 2015, 10: e0145994.

Hu J., WONG N.K., LU M., Chen X., YE S., Zhao Q., Gao P., Kao R.Y.T., Shen J. and Yang D., HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay, Chem. Sci.. 2016, 7: 2094-2099.

LAI T.P., WANG R., Zhang H., Kao R.Y.T. and Sun H., Characterization of Metallodrugs Binding to NDM-1 Offers New Insight into Ways of Overcoming Antibiotic Resistance, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2015.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

WANG W., LI T.L., Wong H.M., Chu P.K., Kao R.Y.T., Wu S., Leung F.K.L., Wong T.M., To M.K.T., Cheung K.M.C. and Yeung K.W.K., Development of novel implants with self-antibacterial performance through in-situ growth of 1D ZnO nanowire, Colloids and Surfaces B: Biointerfaces. 2016, 141: 623-633.

Yeung K.W.K., Cheung K.M.C., Luk K.D.K., Yeung C.Y., Kao R.Y.T. and Chu P.K., Antibacterial surface and method of fabrication, European Non-Provisional Patent Application Granted (No. 2398517). 2016.

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Researcher : Ke Y

List of Research Outputs

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : Kok KH

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity
Investigator(s):	Kok KH, Chan CP
Department:	Biochemistry
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Role of PACT in host antiviral defence against influenza A virus
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	10/2016

Project Title:	Characterization of an alternatively spliced tumor suppressor FAT1 in hepatocellular carcinoma
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2014

Project Title:	Suppression of PACT-dependent antiviral response by measles virus V protein
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Innate immune sensing of rotavirus
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Functional role of PACT in limiting replication of influenza A virus
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2016

Project Title:	The 35th annual meeting of the American Society for Virology; Loss of immunostimulative property of Sendai virus-derived defective-interfering RNA by adenosine-to-inosine editing
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	06/2016

List of Research Outputs

CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.

CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015.

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016.

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015.

HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568.

Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015.

WANG P., Siu K.L., ZHANG Y., Yang W. and Kok K.H., A novel transcript isoform of STING that suppresses innate antiviral response, The American Society for Virology 34th Annual Meeting. 2015.

Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016.

YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912.

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015.

Researcher : Kwong TC

List of Research Outputs

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Researcher : LAW YT

List of Research Outputs

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : LEE BK

List of Research Outputs

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : LEE CY

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Researcher : LI T

List of Research Outputs

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Researcher : LIU S

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : LO CS

List of Research Outputs

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Researcher : LUK KH

List of Research Outputs

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Lai ELY

List of Research Outputs

Ho P.L., Lai E.L.Y. and Chow K.H., Carriage of meticillin-susceptible and -resistant Staphylococcus aureus by medical students in Hong Kong, Journal of Hospital Infection. 2015.

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : Lam SF

List of Research Outputs

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Lau CY

List of Research Outputs

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Researcher : Lau S.K.P.

Project Title:	Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):	Lau SKP, Woo PCY, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013

Project Title:	Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Genomic characterization of a novel rat bocaparvovirus from Norway rats in China
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

List of Research Outputs

Researcher : Lau SKP

Project Title:	Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):	Lau SKP, Woo PCY, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013

Project Title:	Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Genomic characterization of a novel rat bocaparvovirus from Norway rats in China
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., TSANG C.C., Yang J., Xing F., Leung S.M., Ngan A.H.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Trichomonascus (Candida) ciferrii isolates associated with granular myringitis, European Congress of Clinical Microbiology and Infectious Diseases, ECCMID 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients., Emerging Microbes And Infections. 2016, 5: e19.

Fernando N., Hui S.W., TSANG C.C., Leung S.Y., Ngan A.H., Leung R.W., Groff J.M., Lau S.K.P. and Woo P.C.Y., Fatal Fusarium solani species complex infections in elasmobranchs: the first case report for black spotted stingray (Taeniura melanopsila) and a literature review, Mycoses. 2015, 58: 422-431.

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Lau S.K.P. and Woo P.C.Y., Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential., Trends in Microbiology. 2016, 24: 427-429.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Lau S.K.P., Chan J.F.W., TSANG C.C., Chan S.M., Ho M.L., Que T.L., Lau Y.L. and Woo P.C.Y., Human oropharynx as natural reservoir of Streptobacillus hongkongensis, Scientific Reports. 2016, 6: 24419.

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Lin A.W., Sridhar S., Wong K.H., Lau S.K.P. and Woo P.C.Y., Epidemiology of sexually transmitted viral hepatitis in human immunodeficiency virus-positive men who have sex with men in Asia., Journal of the Formosan Medical Association. 2015, 114: 1154-1161.

Lin W.C., Lau S.K.P. and Woo P.C.Y., Screening and treatment of latent tuberculosis infection among HIV-infected patients in resource-rich settings., Expert Revew of Anti-Infective Therapy. 2016, 14: 489-500.

Sridhar S., Lau S.K.P. and Woo P.C.Y., A diagnostic pitfall: Salmonella splenic infarction in hereditary spherocytosis, American Journal of Medicine. 2015.

Sridhar S., Teng L.L., Lau S.K.P. and Woo P.C.Y., Fatal bacteremic melioidosis in patients with prolonged neutropenia., Diagnostic Microbiology and Infectious Disease. 2016, 84: 258-260.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

Sridhar S., Fung K.S., Chan J.F.W., Lam J.Y., Yip E.K., Hung F.N.I., Wu A.K., Que T.L., Lau S.K.P. and Woo P.C.Y., High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study., BMC Infectious Diseases. 2016, 16: 74.

Sridhar S., Wong S.S.Y., Tam W.T., Woo P.C.Y. and Lau S.K.P., Report of isolation of Cryptobacterium curtum from a pelvic abscess, JMM Case Reports. 2015, 2.

TANG Y., Teng L.L., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analysis of Streptococcus sinensis HKU4T reveals a novel phylogenetic group in the genus Streptococcus, American Society for Microbiology. ASM Microbe 2016. June 16-20, Boston, USA.. 2016.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Polyketides, toxins and pigments in Penicillium marneffei, Toxins. 2015, 7: 4421-4436.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

Wernery U., Lau S.K.P. and Woo P.C.Y., Genomics and zoonotic infections: Middle East respiratory syndrome., Revue Scientifique et Technique. 2016, 35: 191-202.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Woo P.C.Y., Poon W.S.R., Foo C.H., To K.K.W. and Lau S.K.P., First Report of Laribacter hongkongensis Peritonitis in Continuous Ambulatory Peritoneal Dialysis., Peritoneal Dialysis International. 2016, 36: 105-107.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Xiong L., Teng L.L., Botelho M.G., Lo C.L.R., Lau S.K.P. and Woo P.C.Y., Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy, International Journal of Molecular Sciences. 2016, 17: 363.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Zhao Y., Chan J.F.W., TSANG C.C., Wang H., Guo D., Pan Y., Xiao Y., Yue N., Chen J.H.K., Lau S.K.P., Xu Y. and Woo P.C.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study , Journal of Clinical Microbiology. 2015, 53: 3639-3645.

Zhao Y., TSANG C.C., Xiao M., Cheng J., Xu Y., Lau S.K.P. and Woo P.C.Y., Intra-genomic internal transcribed spacer region sequence heterogeneity and molecular diagnosis in clinical microbiology, International Journal of Molecular Sciences. 2015, 16: 25067-25079.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Researcher : Lau SY

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

Xu L.L., Bao L.L., Lau S.Y., Wu W.L., Yuan J., Gu S.Z., Li F.D., Lv Q., Xu Y.F., Pushko P., Chen H. and Qin C., Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice, VACCINE. UK, ELSEVIER SCI LTD, 2016, 34: 2627-2633.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Law PYT

List of Research Outputs

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Researcher : Lee CY

List of Research Outputs

Researcher : Lee KC

List of Research Outputs

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : Lee MY

Project Title:	Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):	Lee MY, Lok S, Cheung CY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	05/2009

Project Title:	Determining the ligand and function of TLR10: a novel innate immune sensor in viral infection
Investigator(s):	Lee MY, Jin D, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014

Project Title:	TOLL 2015 Targeting Innate Immunity; Role of TLR10 as an innate immune sensor for influenza virus infection
Investigator(s):	Lee MY
Department:	School of Public Health
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	10/2015

Project Title:	Determining the involvement of TLR10-a novel innate immune sensor in influenza virus pathogenesis
Investigator(s):	Lee MY, Sanyal S
Department:	School of Public Health
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Researcher : Lee RA

List of Research Outputs

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Lee WM

List of Research Outputs

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Cheng V.C.C., Lee W.M., Sridhar S., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong, Journal of Hospital Infection. 2015, 90: 355-356.

Researcher : Leung HC

List of Research Outputs

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Leung SS

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Researcher : Leung SY

List of Research Outputs

Fernando N., Hui S.W., TSANG C.C., Leung S.Y., Ngan A.H., Leung R.W., Groff J.M., Lau S.K.P. and Woo P.C.Y., Fatal Fusarium solani species complex infections in elasmobranchs: the first case report for black spotted stingray (Taeniura melanopsila) and a literature review, Mycoses. 2015, 58: 422-431.

Researcher : Li C

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Researcher : Li C

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Researcher : Li C

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Researcher : Li KSM

List of Research Outputs

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Researcher : Li T

List of Research Outputs

Researcher : Li TW

List of Research Outputs

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Researcher : Li WS

List of Research Outputs

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : Lin WC

List of Research Outputs

Lin W.C., Lau S.K.P. and Woo P.C.Y., Screening and treatment of latent tuberculosis infection among HIV-infected patients in resource-rich settings., Expert Revew of Anti-Infective Therapy. 2016, 14: 489-500.

Researcher : Liu D

List of Research Outputs

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Liu L

Project Title:	Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):	Liu L
Department:	LKS Medical Faculty
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	09/2009

Project Title:	Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection
Investigator(s):	Liu L, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2014

Project Title:	A novel small molecule from natural product as a potential agent for purging HIV-1 from the latent reservoir
Investigator(s):	Liu L
Department:	LKS Medical Faculty
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Defining the role of monocyte-derived dendritic cells in potentiating durable and protective T-cell immunity by a newly identified PD-1 isoform
Investigator(s):	Liu L, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	4th European Congress of Immunology; Spatiotemporal Interplay of Severe Acute Respiratory Syndrome Coronavirus and Respiratory Mucosal Cells Drives Viral Dissemination in Rhesus Macaques
Investigator(s):	Liu L
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

Project Title:	Mechanisms of viral evasion of vaccine induced T cell immune response
Investigator(s):	Liu L
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Cheung K.W., Peng Q., He L., Cai K., Jiang Q., Zhou B., To W.C.S., Yam W.C., Liu L., Chen Z., Wang H. and Tee K.K., Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System, PLOS ONE. 2016, 11: e0153641.

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Liu Y

List of Research Outputs

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Lo NTL

List of Research Outputs

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Lo WU

Project Title:	Prevalence and Molecular Characterisation of Novel Chimeric β-lactamases in Escherichia coli from Human and Animals
Investigator(s):	Lo WU, Ho PL
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015
Completion Date:	12/2015

List of Research Outputs

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : Lui YM

List of Research Outputs

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Researcher : Luk KH

List of Research Outputs

Researcher : Lung DC

List of Research Outputs

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Researcher : Mak WN

List of Research Outputs

Leung O.N., Mak W.N., Kai A.K.L., CHAN K.S., Lee K.W., Ng I.O.L. and Lo C.L.R., Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling., Oncotarget. 2016.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Junior Investigator Award, International Liver Cancer Association Annual Conference 2015. 2015.

Lo C.L.R., Leung O.N., Mak W.N. and Lee K.W., Top scored abstract, International Liver Cancer Association Annual Conference 2015. 2015.

Researcher : Mok BWY

Project Title:	The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response
Investigator(s):	Mok BWY, Chen H
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	Exploring the role of influenza virus NS1 in microRNA-mediated regulation of the innate immune response
Investigator(s):	Mok BWY, Chen H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Mok KY

List of Research Outputs

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Researcher : NG KY

List of Research Outputs

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : Ng F

List of Research Outputs

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Ng SP

Project Title:	Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):	Ng SP, Yam WC
Department:	Microbiology
Source(s) of Funding:	Environment Protection Department - General Award
Start Date:	06/2001

Researcher : Peiris JSM

Project Title:	IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):	Peiris JSM, Guan Y
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	04/2003

Project Title:	Virus-cell interaction and the pathogenesis of SARS
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):	Peiris JSM, Guan Y, Lau ASY, Poon LML
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2003

Project Title:	Outstanding Researcher Award 2003-2004
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	07/2004

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2005

Project Title:	The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	The Wellcome Trust - General Award
Start Date:	01/2007

Project Title:	Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Collaborating Project Fund
Start Date:	06/2007

Project Title:	Control of Pandemic and Inter-pandemic Influenza
Investigator(s):	Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Host responses that correlate with respiratory droplet transmission of swine-origin influenza viruses in ferrets
Investigator(s):	Peiris JSM, Yen H, Nicholls JM
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	11/2016

Project Title:	Risk assessing human transmission potential of H7N9 viruses using ex vivo cultures of the human respiratory tract
Investigator(s):	Peiris JSM, Nicholls JM, Chan MCW, Chan WY, Lai JCC, Mok KP
Department:	School of Public Health
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	05/2014
Completion Date:	06/2016

Project Title:	Surveillance of influenza A including subtype H7N9 in outpatients with influenza-like illness and hospitalized patients with severe acute respiratory illness (SARI) presenting at The First Affiliated Hospital of Guangzhou Medical University
Investigator(s):	Peiris JSM, Mok KP, Cowling BJ
Department:	School of Public Health
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	05/2014
Completion Date:	03/2016

Project Title:	Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis
Investigator(s):	Peiris JSM, Cowling BJ, Guan Y, Li Y, Nicholls JM, Poon LML, Tu W, Yen H, Zhu H, Chan MCW, Lam TY, Jin D, Lee MY, Sanyal S, Mok KP, Sham PC
Department:	School of Public Health
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2015

Project Title:	Public Health Responses to threats of emerging, epidemic and endemic infectious diseases
Investigator(s):	Peiris JSM, Cowling BJ, Wu JTK, Guan Y
Department:	School of Public Health
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

Project Title:	Role of influenza virus surface glycoproteins in virus-induced cell stress and inflammation
Investigator(s):	Peiris JSM, Yen H
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	HKU Centennial Distinguished Chinese Scholars Scheme 2015-16
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:	09/2015

Researcher : Poon KM

List of Research Outputs

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Poon LLM

Project Title:	Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):	Poon LML, Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):	Poon LML
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2003

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Poon LML
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Generation of live attenuated influenza viruses of vaccine potential by using codon usage bias
Investigator(s):	Poon LML
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2013
Completion Date:	04/2016

Project Title:	Characterization of fibronectin-mediated influenza A virus infection in human cells.
Investigator(s):	Poon LML, Chan WY
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Generation of a replication-incompetent NP-knockout influenza virus that allows expression of galactose-alpha-1,3-galactose (alpha-Gal) in infected cells to enhance adaptive immune response
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Vaccination scheme development to stimulate both B and T cell dependent heterosubtypic protection against Influenza A viruses in mice
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Researcher : Poon WSR

List of Research Outputs

Chan J.F.W., Tee K.M., Choi G.K.Y., Zhu Z., Poon W.S.R. and Yuen K.Y., Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction, 35th Annual Meeting of the American Society for Virology (ASV 2016), American Society for Virology. 2016.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

Woo P.C.Y., Poon W.S.R., Foo C.H., To K.K.W. and Lau S.K.P., First Report of Laribacter hongkongensis Peritonitis in Continuous Ambulatory Peritoneal Dialysis., Peritoneal Dialysis International. 2016, 36: 105-107.

Researcher : Que TL

List of Research Outputs

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Researcher : SHUAI H

List of Research Outputs

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Researcher : She KKK

List of Research Outputs

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Researcher : Siu GKH

List of Research Outputs

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Siu G.K.H., Chen H.K.J., Ng T.K., Lee R.A., Fung K.S.C., To W.C.S., Wong B.K.C., Cheung S., Wong I.W.F., Tam M.M.P., Lee S.S.W. and Yam W.C., Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong, PLOS ONE. 2015, 10: e0139728.

Researcher : Smith GJ

Project Title:	Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	05/2007

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Researcher : Song W

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Sridhar S

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Cheng V.C.C., Lee W.M., Sridhar S., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong, Journal of Hospital Infection. 2015, 90: 355-356.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Lin A.W., Sridhar S., Wong K.H., Lau S.K.P. and Woo P.C.Y., Epidemiology of sexually transmitted viral hepatitis in human immunodeficiency virus-positive men who have sex with men in Asia., Journal of the Formosan Medical Association. 2015, 114: 1154-1161.

Sridhar S., Lau S.K.P. and Woo P.C.Y., A diagnostic pitfall: Salmonella splenic infarction in hereditary spherocytosis, American Journal of Medicine. 2015.

Sridhar S., Teng L.L., Lau S.K.P. and Woo P.C.Y., Fatal bacteremic melioidosis in patients with prolonged neutropenia., Diagnostic Microbiology and Infectious Disease. 2016, 84: 258-260.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

Sridhar S., Fung K.S., Chan J.F.W., Lam J.Y., Yip E.K., Hung F.N.I., Wu A.K., Que T.L., Lau S.K.P. and Woo P.C.Y., High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study., BMC Infectious Diseases. 2016, 16: 74.

Researcher : Sze KH

Project Title:	XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Structure-function study of virulence factor Macrophage Infectivity Potentiator of Coxiella burnetii and Legionella pneumophila
Investigator(s):	Sze KH, Yuen KY, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2013

Project Title:	Host target identification and characterization for the secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB)
Investigator(s):	Sze KH, Yuen KY, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2014

Project Title:	Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):	Sze KH, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	System Biology investigation on virulence factors of methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):	Sze KH, Yuen KY, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Host target characterizations for early secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB)
Investigator(s):	Sze KH, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	ISMAR 2015; Structure and function studies of a novel class of virulence factor Mp1p in Penicillium marneffei /Structure and function studies of virulence factors EsxA and EsxB of methicillin-resistant Staphylococcus aureus and in silico structure-based screening on EsxA
Investigator(s):	Sze KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

List of Research Outputs

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimer RING Finger: Insight into the Therapeutic Properties of Arsenic(III) Trioxide, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2015.

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimeric RING Finger: Insight into the Terapeutic Properties of Arsenic (III) Trioxide, Poster Conference, 6th Asia-Pacific NMR Symposium, Hong Kong University of Science & Technology, Hong Kong, August 13-16, 2015.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Researcher : TANG J

List of Research Outputs

TANG J., Yam W.C. and Chen Z., Mycobacterium tuberculosis infection and vaccine development, Tuberculosis. 2016, 98: 30-41.

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : TANG Y

List of Research Outputs

TANG Y., Teng L.L., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analysis of Streptococcus sinensis HKU4T reveals a novel phylogenetic group in the genus Streptococcus, American Society for Microbiology. ASM Microbe 2016. June 16-20, Boston, USA.. 2016.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

Researcher : TONG S

List of Research Outputs

VERHOEVEN R.J.A., TONG S., Zhang G.H. and Chen H., Regulation and functions of Epstein-Barr virus encoded miRNA and non-coding RNA in nasopharyngeal carcinoma, AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicine, December 4-7, 2015 in Boston, MA, USA. 2015.

Researcher : TSANG CC

List of Research Outputs

Chan J.F.W., TSANG C.C., Yang J., Xing F., Leung S.M., Ngan A.H.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Trichomonascus (Candida) ciferrii isolates associated with granular myringitis, European Congress of Clinical Microbiology and Infectious Diseases, ECCMID 2016.

Fernando N., Hui S.W., TSANG C.C., Leung S.Y., Ngan A.H., Leung R.W., Groff J.M., Lau S.K.P. and Woo P.C.Y., Fatal Fusarium solani species complex infections in elasmobranchs: the first case report for black spotted stingray (Taeniura melanopsila) and a literature review, Mycoses. 2015, 58: 422-431.

Lau S.K.P., Chan J.F.W., TSANG C.C., Chan S.M., Ho M.L., Que T.L., Lau Y.L. and Woo P.C.Y., Human oropharynx as natural reservoir of Streptobacillus hongkongensis, Scientific Reports. 2016, 6: 24419.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Polyketides, toxins and pigments in Penicillium marneffei, Toxins. 2015, 7: 4421-4436.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Zhao Y., Chan J.F.W., TSANG C.C., Wang H., Guo D., Pan Y., Xiao Y., Yue N., Chen J.H.K., Lau S.K.P., Xu Y. and Woo P.C.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study , Journal of Clinical Microbiology. 2015, 53: 3639-3645.

Zhao Y., TSANG C.C., Xiao M., Cheng J., Xu Y., Lau S.K.P. and Woo P.C.Y., Intra-genomic internal transcribed spacer region sequence heterogeneity and molecular diagnosis in clinical microbiology, International Journal of Molecular Sciences. 2015, 16: 25067-25079.

Researcher : Tai JWM

List of Research Outputs

Cheng V.C.C., Chau P.H., Lee W.M., Ho S.K.Y., Lee D.W.Y., So S.Y.C., Wong S.C.Y., Tai J.W.M. and Yuen K.Y., Hand-touch contact assessment of high-touch and mutual-touch surfaces among healthcare workers, patients, and visitors, Journal of Hospital Infection. 2015, 90: 220-225.

Cheng V.C.C., Tai J.W.M., Li W.S., Chau P.H., So S.Y.C., Wong L.M.W., Ching R.H.C., Ng M.M.L., Ho S.K.Y., Lee D.W.Y., Lee W.M., Wong S.C.Y. and Yuen K.Y., Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong, American Journal of Infection Control. 2016, 44: 621-624.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Researcher : Tam WT

List of Research Outputs

Sridhar S., Wong S.S.Y., Tam W.T., Woo P.C.Y. and Lau S.K.P., Report of isolation of Cryptobacterium curtum from a pelvic abscess, JMM Case Reports. 2015, 2.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Polyketides, toxins and pigments in Penicillium marneffei, Toxins. 2015, 7: 4421-4436.

Researcher : Tan Z

Project Title:	Role of Δ42PD1/TLR4 interaction in human hepatocellular carcinoma and its blockade as a novel immunotherapy strategy
Investigator(s):	Tan Z, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

List of Research Outputs

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Tang SF

List of Research Outputs

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

Researcher : Tang Y

List of Research Outputs

Researcher : Tee KM

List of Research Outputs

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Chan J.F.W., Tee K.M., Choi G.K.Y., Zhu Z., Poon W.S.R. and Yuen K.Y., Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction, 35th Annual Meeting of the American Society for Virology (ASV 2016), American Society for Virology. 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Tee K.M., Choi G.K.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Urinary shedding pattern of polyomaviruses in patients with ketamine uropathy, 34th Annual Meeting of the American Society for Virology (ASV 2015), American Society for Virology. 2015.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Researcher : Teng LL

Project Title:	Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):	Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2006

Project Title:	The complete genome sequencing and phylogenomic analysis of Streptococcus sinensis, a novel bacterium associated with infective endocarditis
Investigator(s):	Teng LL, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2014
Completion Date:	04/2016

List of Research Outputs

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Sridhar S., Teng L.L., Lau S.K.P. and Woo P.C.Y., Fatal bacteremic melioidosis in patients with prolonged neutropenia., Diagnostic Microbiology and Infectious Disease. 2016, 84: 258-260.

TANG Y., Teng L.L., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analysis of Streptococcus sinensis HKU4T reveals a novel phylogenetic group in the genus Streptococcus, American Society for Microbiology. ASM Microbe 2016. June 16-20, Boston, USA.. 2016.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Xiong L., Teng L.L., Botelho M.G., Lo C.L.R., Lau S.K.P. and Woo P.C.Y., Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy, International Journal of Molecular Sciences. 2016, 17: 363.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : To KKW

Project Title:	Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):	To KKW, Ho PL, Chan KH, Hung FNI, Chiu SSS
Department:	Microbiology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	07/2011

Project Title:	Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers
Investigator(s):	To KKW, Hung FNI, Yuen KY, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Centre for Health Protection
Start Date:	09/2013

Project Title:	Identification of innate immune defect predisposing to severe influenza in a Chinese population
Investigator(s):	To KKW, Zhou J, Song Y, Hung FNI, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013
Completion Date:	09/2016

Project Title:	Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers (CHP-PH-11)
Investigator(s):	To KKW
Department:	Microbiology
Source(s) of Funding:	Commissioned Project: Health and Medical Research Fund
Start Date:	10/2013

Project Title:	29th International Conference on Antiviral Research; Antiviral activity of mycophenolic acid against seasonal influenza viruses and avian influenza virus A(H5N1)
Investigator(s):	To KKW
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2016
Completion Date:	04/2016

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan K.H., Yeung M.L., To K.K.W., Markovitz D.M. and Yuen K.Y., Rediscovery of Banana Lectin (BanLec) as a Pan-coronavirus Antiviral: In Vitro & Ex Vivo evidence, 55th Interscience Conference on Antimicrobial Agents and Chemotherapy / 28th International Congress of Chemotherapy and Infection (ICAAC/ICC 2015). 2015.

Chan J.F.W., Tee K.M., Choi G.K.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Urinary shedding pattern of polyomaviruses in patients with ketamine uropathy, 34th Annual Meeting of the American Society for Virology (ASV 2015), American Society for Virology. 2015.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Cheong K.N., Chiu S.S.S., Chan B.W., To K.K.W., Chan L.Y. and Ho P.L., Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure, Journal of Microbiology, Immunology and Infection. 2016, 49: 127-130.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

To K.K.W., Antiviral activity of mycophenolic acid against seasonal influenza viruses and avian influenza virus A(H5N1), 29th International Conference on Antiviral Research (ICAR),. 2016.

To K.K.W., Empirical antibiotics for community-acquired MSK (SSTI) infection, 13th International Orthopedic Forum. 2016.

To K.K.W., Evaluation of saliva specimens for the diagnosis of influenza in adult patients, 32nd Clinical Virology Symposium 2016.

To K.K.W., Group B Streptococcus, Commissioned Training Programme 2015/16, Hong Kong Institute of Advanced Allied Health Studies of the Hospital Authority. 2015.

To K.K.W., History taking, physical examination, investigation and diagnosis in infectious disease, Post-registration Certificate Course in Infectious Disease Nursing 2016. 2016.

To K.K.W., Zhou J., Chan J.F.W. and Yuen K.Y., Host genes and influenza pathogenesis in humans: an emerging paradigm, Current Opinion in Virology. 2015, 14: 7-15.

To K.K.W., Host genetic susceptibility to severe influenza, The Global Emergency Medicine Meeting (HKU Shenzhen Hospital). 2015.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Human Rhinovirus Infection in Patients Requiring Intensive Care Unit Admission, ICAAC/ICC 2015.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

To K.K.W., Sepsis in Pregnancy, Obstetrics and gynecology Postgraduate Study Day. 2015.

To K.K.W., Seroprevalence to Influenza Virus A(H5N1), A(H7N9) and A(H9N2) among Workers in Live Poultry Market and Slaughterhouse in Hong Kong before and after the 2013 A(H7N9) Human Winter Epidemic, American Society for Virology 34th Annual Meeting, July 11-15, 2015, Western University, London, Ontario, Canada. 2015.

To K.K.W., Sir Patrick Manson Gold Medal , The University of Hong Kong. 2015.

To K.K.W., Surgical site infection in Orthopedics, 13th International Orthopedic Forum. 2016.

Wong S.S.Y., Poon R.W.S., Chau S., Wong S.C.Y., To K.K.W., Cheng V.C.C., Fung K.S.C. and Yuen K.Y., Development of Conventional and Real-Time Quantitative PCR Assays for Diagnosis and Monitoring of Scabies, Journal of Clinical Microbiology. 2015, 53: 2095-2102.

Woo P.C.Y., Poon W.S.R., Foo C.H., To K.K.W. and Lau S.K.P., First Report of Laribacter hongkongensis Peritonitis in Continuous Ambulatory Peritoneal Dialysis., Peritoneal Dialysis International. 2016, 36: 105-107.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : To WCS

Project Title:	Pharmacogenomic and molecular epidemiological study of HIV/AIDS patients co-infected with Hepatitis C virus (HCV)
Investigator(s):	To WCS, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	10/2015

List of Research Outputs

Cheung K.W., Peng Q., He L., Cai K., Jiang Q., Zhou B., To W.C.S., Yam W.C., Liu L., Chen Z., Wang H. and Tee K.K., Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System, PLOS ONE. 2016, 11: e0153641.

Siu G.K.H., Chen H.K.J., Ng T.K., Lee R.A., Fung K.S.C., To W.C.S., Wong B.K.C., Cheung S., Wong I.W.F., Tam M.M.P., Lee S.S.W. and Yam W.C., Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong, PLOS ONE. 2015, 10: e0139728.

To W.C.S. and Yam W.C., An overview of drug resistance mutations in HIV-1 pol gene (Hong Kong, 1994 - 2013), 1st Asia Pacific Conference on AIDS & Co-infections: Translating Science into Clinical Practice. 2016.

Researcher : Tsang DNC

List of Research Outputs

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Researcher : Tsang KL

List of Research Outputs

Chan J.F.W., Chan K.H., Cai J., Tsang K.L., Markovitz D.M. and Yuen K.Y., BanLec Inhibits Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by Binding with the S1 Subunit of the Viral Spike Glycoprotein, 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Tse H

Project Title:	Molecular characterization of antibiotic resistance in Staphylococcus lugdunensis isolates
Investigator(s):	Tse H, Ho PL
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	11/2016

Project Title:	Molecular characterization of tetracycline resistance in Elizabethkingia anophelis
Investigator(s):	Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	06/2016

List of Research Outputs

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Yap Y.H.D., Tse H., Mok M.M., Chan G.C., Yip T., Lui S.L., Lo W.K. and Chan D.T.M., Arthrobacter sanguinis: an uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2015, 20(11): 868.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Researcher : Tse MK

List of Research Outputs

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimer RING Finger: Insight into the Therapeutic Properties of Arsenic(III) Trioxide, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2015.

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimeric RING Finger: Insight into the Terapeutic Properties of Arsenic (III) Trioxide, Poster Conference, 6th Asia-Pacific NMR Symposium, Hong Kong University of Science & Technology, Hong Kong, August 13-16, 2015.

Researcher : VERHOEVEN RJA

List of Research Outputs

VERHOEVEN R.J.A., TONG S., Zhang G.H. and Chen H., Regulation and functions of Epstein-Barr virus encoded miRNA and non-coding RNA in nasopharyngeal carcinoma, AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicine, December 4-7, 2015 in Boston, MA, USA. 2015.

Researcher : WANG Y

List of Research Outputs

Ho P.L., CHEUNG Y.Y., WANG Y., Lo W.U., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2016, 35: 379-385.

Ho P.L., NG K.Y., Lo W.U., LAW Y.T., Lai E.L.Y., WANG Y. and Chow K.H., Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy. 2016, 60: 537-543.

Researcher : WONG CW

List of Research Outputs

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Researcher : WU X

List of Research Outputs

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Wang D

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Researcher : Wang P

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Wong CP

List of Research Outputs

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Researcher : Wong HYB

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Researcher : Wong KH

List of Research Outputs

Leung C.C., Chan K.C.W., Yam W.C., Lee M.P., Chan C.K., Wong K.H., Ho P.L., Mak I. and Tam C.M., Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong, Respirology. 2016.

Researcher : Wong LWM

List of Research Outputs

Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016.

YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912.

Researcher : Wong OY

List of Research Outputs

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Researcher : Wong SCY

List of Research Outputs

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Cheng V.C.C., Chau P.H., Lee W.M., Ho S.K.Y., Lee D.W.Y., So S.Y.C., Wong S.C.Y., Tai J.W.M. and Yuen K.Y., Hand-touch contact assessment of high-touch and mutual-touch surfaces among healthcare workers, patients, and visitors, Journal of Hospital Infection. 2015, 90: 220-225.

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Cheng V.C.C., Tai J.W.M., Li W.S., Chau P.H., So S.Y.C., Wong L.M.W., Ching R.H.C., Ng M.M.L., Ho S.K.Y., Lee D.W.Y., Lee W.M., Wong S.C.Y. and Yuen K.Y., Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong, American Journal of Infection Control. 2016, 44: 621-624.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Researcher : Wong SSY

Project Title:	Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):	Wong SSY, Yuen KY, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):	Wong SSY, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Discovery and characterization of novel Tsukamurella species: a 14-year retrospective analysis
Investigator(s):	Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

Project Title:	Genome sequencing of clinical and environmental isolates of Burkholderia pseudomallei: implications for the most common sequence type circulating in Hong Kong
Investigator(s):	Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Sridhar S., Wong S.S.Y., Tam W.T., Woo P.C.Y. and Lau S.K.P., Report of isolation of Cryptobacterium curtum from a pelvic abscess, JMM Case Reports. 2015, 2.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

Wong S.S.Y., Poon R.W.S., Chau S., Wong S.C.Y., To K.K.W., Cheng V.C.C., Fung K.S.C. and Yuen K.Y., Development of Conventional and Real-Time Quantitative PCR Assays for Diagnosis and Monitoring of Scabies, Journal of Clinical Microbiology. 2015, 53: 2095-2102.

Wong S.S.Y., SARS coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination, Journal of Virology. 2015, JVI.01048-15.

Wong S.S.Y., Poon R.W.S. and Wong S.C.Y., Zika virus infection—the next wave after dengue?, Journal of the Formosan Medical Association. 2016, 115: 226-242.

Researcher : Wong TL

List of Research Outputs

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

Researcher : Wong YM

List of Research Outputs

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Woo P.C.Y.

Project Title:	Infection and Immunology
Investigator(s):	Woo PCY, Yuen KY, Watt RM
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):	Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014

Project Title:	Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):	Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:	Microbiology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2015

Project Title:	Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Novel Microbe Discovery and Microbial Genomics
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

List of Research Outputs

Researcher : Woo PCY

Project Title:	Infection and Immunology
Investigator(s):	Woo PCY, Yuen KY, Watt RM
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2015

Project Title:	Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):	Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014

Project Title:	Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):	Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:	Microbiology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2015

Project Title:	Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Novel Microbe Discovery and Microbial Genomics
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., TSANG C.C., Yang J., Xing F., Leung S.M., Ngan A.H.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Trichomonascus (Candida) ciferrii isolates associated with granular myringitis, European Congress of Clinical Microbiology and Infectious Diseases, ECCMID 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients., Emerging Microbes And Infections. 2016, 5: e19.

Fernando N., Hui S.W., TSANG C.C., Leung S.Y., Ngan A.H., Leung R.W., Groff J.M., Lau S.K.P. and Woo P.C.Y., Fatal Fusarium solani species complex infections in elasmobranchs: the first case report for black spotted stingray (Taeniura melanopsila) and a literature review, Mycoses. 2015, 58: 422-431.

Joseph S., Wernery U., Teng L.L., Wernery R., Huang Y., Patteril N.A., Chan K.H., Elizabeth S.K., Fan Y.Y., Lau S.K.P., Kinne J. and Woo P.C.Y., First isolation of West Nile virus from a dromedary camel., Emerging Microbes and Infections. 2016, 5: e53.

Lau S.K.P., Chow W.N., Foo C.H., Curreem S.O.T., LO C.S., Teng L.L., Chen H.K.J., Ng R.H., Wu A.K., Cheung I.Y., Chau S.K., Lung D.C., Lee R.A., Tse C.W., Fung K.S., Que T.L. and Woo P.C.Y., Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality., Scientific Reports. 2016, 6: 26045.

Lau S.K.P. and Woo P.C.Y., Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential., Trends in Microbiology. 2016, 24: 427-429.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Lau S.K.P., Chan J.F.W., TSANG C.C., Chan S.M., Ho M.L., Que T.L., Lau Y.L. and Woo P.C.Y., Human oropharynx as natural reservoir of Streptobacillus hongkongensis, Scientific Reports. 2016, 6: 24419.

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Lin A.W., Sridhar S., Wong K.H., Lau S.K.P. and Woo P.C.Y., Epidemiology of sexually transmitted viral hepatitis in human immunodeficiency virus-positive men who have sex with men in Asia., Journal of the Formosan Medical Association. 2015, 114: 1154-1161.

Lin W.C., Lau S.K.P. and Woo P.C.Y., Screening and treatment of latent tuberculosis infection among HIV-infected patients in resource-rich settings., Expert Revew of Anti-Infective Therapy. 2016, 14: 489-500.

Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39.

Sridhar S., Lau S.K.P. and Woo P.C.Y., A diagnostic pitfall: Salmonella splenic infarction in hereditary spherocytosis, American Journal of Medicine. 2015.

Sridhar S., Teng L.L., Lau S.K.P. and Woo P.C.Y., Fatal bacteremic melioidosis in patients with prolonged neutropenia., Diagnostic Microbiology and Infectious Disease. 2016, 84: 258-260.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

Sridhar S., Fung K.S., Chan J.F.W., Lam J.Y., Yip E.K., Hung F.N.I., Wu A.K., Que T.L., Lau S.K.P. and Woo P.C.Y., High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study., BMC Infectious Diseases. 2016, 16: 74.

Sridhar S., Wong S.S.Y., Tam W.T., Woo P.C.Y. and Lau S.K.P., Report of isolation of Cryptobacterium curtum from a pelvic abscess, JMM Case Reports. 2015, 2.

TANG Y., Teng L.L., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analysis of Streptococcus sinensis HKU4T reveals a novel phylogenetic group in the genus Streptococcus, American Society for Microbiology. ASM Microbe 2016. June 16-20, Boston, USA.. 2016.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Polyketides, toxins and pigments in Penicillium marneffei, Toxins. 2015, 7: 4421-4436.

Tang Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurella serpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra) in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016.

Teng L.L., TANG Y., Wong S.S.Y., Ngan A.H.Y., Huang Y., TSANG C.C., CHOI K.Y., Lau S.K.P. and Woo P.C.Y., Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis, International Journal of Systematic and Evolutionary Microbiology. 2015, 66: 391-397.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

Wernery U., Lau S.K.P. and Woo P.C.Y., Genomics and zoonotic infections: Middle East respiratory syndrome., Revue Scientifique et Technique. 2016, 35: 191-202.

Woo P.C.Y., 13. A microbiologist’s perspective of pelvic inflammatory disease and bacterial vaginosis., OGSHK ASM and Ovarian Club VII. Hong Kong . 2016.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., A sensitive and specific antigen detection assay for MERS coronavirus. , First WHO training workshop on MERS coronavirus laboratory diagnostics in the Eastern Mediterranean region. Dubai, UAE.. 2015.

Woo P.C.Y., Changing epidemiology of Penicillium marneffei infection., Infectious disease symposium 2015, Zhujiang Hospital. Guangzhou, China. . 2015.

Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping., 10th Asia-Pacific Congress of Medical Virology, Taipei, Taiwan.. 2015.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Woo P.C.Y., Poon W.S.R., Foo C.H., To K.K.W. and Lau S.K.P., First Report of Laribacter hongkongensis Peritonitis in Continuous Ambulatory Peritoneal Dialysis., Peritoneal Dialysis International. 2016, 36: 105-107.

Woo P.C.Y., From SARS to MERS: more and more coronaviruses. , The Hong Kong Society for Infectious Diseases 20th Annual Scientific Meeting. Hong Kong. 2016.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Woo P.C.Y., Molecular identification and characterization of emerging and novel mould infections., Second Asia Continuous Antifungal Research & Education Forum (Taipei, Taiwan). 2015.

Xiong L., Teng L.L., Botelho M.G., Lo C.L.R., Lau S.K.P. and Woo P.C.Y., Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy, International Journal of Molecular Sciences. 2016, 17: 363.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Zhao Y., Chan J.F.W., TSANG C.C., Wang H., Guo D., Pan Y., Xiao Y., Yue N., Chen J.H.K., Lau S.K.P., Xu Y. and Woo P.C.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study , Journal of Clinical Microbiology. 2015, 53: 3639-3645.

Zhao Y., TSANG C.C., Xiao M., Cheng J., Xu Y., Lau S.K.P. and Woo P.C.Y., Intra-genomic internal transcribed spacer region sequence heterogeneity and molecular diagnosis in clinical microbiology, International Journal of Molecular Sciences. 2015, 16: 25067-25079.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Researcher : Wu AKL

List of Research Outputs

Lau S.K.P., Lam C.S., Ngan A.H., Chow W.N., Wu A.K.L., Tsang D.N.C., Tse C.W., Que T.L., Tang S.F. and Woo P.C.Y., Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei., BMC Microbiology. 2016, 16: 36.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Researcher : Wu L

List of Research Outputs

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Researcher : Wu WL

List of Research Outputs

Xu L.L., Bao L.L., Lau S.Y., Wu W.L., Yuan J., Gu S.Z., Li F.D., Lv Q., Xu Y.F., Pushko P., Chen H. and Qin C., Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice, VACCINE. UK, ELSEVIER SCI LTD, 2016, 34: 2627-2633.

Researcher : Xie J

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Researcher : Xiong L

Project Title:	Bacterial Infection and Host Defense; Molecular characterization of the arginine deiminase pathway, a critical player for insisting acidic condition and intracellular survival in Laribacter hongkongensis
Investigator(s):	Xiong L
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015
Completion Date:	11/2015

List of Research Outputs

Wang H., Pang B., Xiong L., Wang D., Wang X., Zhang L. and Kan B., The Hybrid Pre-ctxφ-rs1 Prophage Genome And Its Regulatory Function In Environmental Vibrio Cholerae O1 Strains, Applied and Environmental Microbiology. USA, American Society for Microbiology, 2015, 20: 7171-7177.

Xiong L., Teng L.L., Botelho M.G., Lo C.L.R., Lau S.K.P. and Woo P.C.Y., Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy, International Journal of Molecular Sciences. 2016, 17: 363.

Xiong L., Molecular Characterization Of The Arginine Deiminase Pathway, A Critical Player For Insisting Acidic Condition And Intracellular Survival In Laribacter Hongkongensis, Cold Spring Harbor Asia Conference: Bacterial Infection And Host Defense.. 2015.

Researcher : YUAN S

List of Research Outputs

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Researcher : YUEN CK

List of Research Outputs

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016.

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015.

Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016.

YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912.

Researcher : Yam WC

Project Title:	Detection of HIV-1 minority drug-resistant and X4-tropic variants by Next-Generation Sequencing to improve the prediction of clinical antiretroviral treatment outcome
Investigator(s):	Yam WC, To WCS, Panagiotou I, Li J
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2016

List of Research Outputs

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Cheung K.W., Peng Q., He L., Cai K., Jiang Q., Zhou B., To W.C.S., Yam W.C., Liu L., Chen Z., Wang H. and Tee K.K., Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System, PLOS ONE. 2016, 11: e0153641.

Ho P.L., Law P.Y.T., Chan B.W., WONG C.W., To K.K.W., Chiu S.S.S., Cheng V.C.C. and Yam W.C., Emergence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong is linked to increasing macrolide resistance in the multilocus variable-number tandem-repeat analysis type 4-5-7-2., J Clin Microbiol. 2015, 53.

Leung C.C., Chan K.C.W., Yam W.C., Lee M.P., Chan C.K., Wong K.H., Ho P.L., Mak I. and Tam C.M., Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong, Respirology. 2016.

Oyomopito R.A., Chen Y.J., Sungkanuparph S., Kantor R., Merati T., Yam W.C., Sirisanthana T., Li P.C., Kantipong P. and Phanuphak P., Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01_AE and subtype B, The Kaohsiung Journal of Medical Sciences. 2015, 31: 445-453.

Siu G.K.H., Chen H.K.J., Ng T.K., Lee R.A., Fung K.S.C., To W.C.S., Wong B.K.C., Cheung S., Wong I.W.F., Tam M.M.P., Lee S.S.W. and Yam W.C., Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong, PLOS ONE. 2015, 10: e0139728.

TANG J., Yam W.C. and Chen Z., Mycobacterium tuberculosis infection and vaccine development, Tuberculosis. 2016, 98: 30-41.

To W.C.S. and Yam W.C., An overview of drug resistance mutations in HIV-1 pol gene (Hong Kong, 1994 - 2013), 1st Asia Pacific Conference on AIDS & Co-infections: Translating Science into Clinical Practice. 2016.

Tsang D.N.C., Lai C.K.C., Yam W.C., Chan J.W.M., Mok Y.W., Seto W.H., Fung S.C., Chu C.M., Lam B.H.S. and Ng T.K., Use of interferon gamma release assay to assess latent tuberculosis infection among healthcare workers in Hong Kong, Hong Kong Medical Journal. 2015, 21: S22-5.

Researcher : Yang D

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Researcher : Yeung C

List of Research Outputs

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Researcher : Yeung ML

Project Title:	Dissecting the roles of tryptophanyl-tRNA synthetase and other host factors contributory to Enterovirus 71 (EV71) replication
Investigator(s):	Yeung ML, Yip CY
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	04/2016

Project Title:	Pathogenesis of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-associated renal failure
Investigator(s):	Yeung ML, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

List of Research Outputs

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan K.H., Yeung M.L., To K.K.W., Markovitz D.M. and Yuen K.Y., Rediscovery of Banana Lectin (BanLec) as a Pan-coronavirus Antiviral: In Vitro & Ex Vivo evidence, 55th Interscience Conference on Antimicrobial Agents and Chemotherapy / 28th International Congress of Chemotherapy and Infection (ICAAC/ICC 2015). 2015.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015.

Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Researcher : Yip CY

List of Research Outputs

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Yip C.Y., Cheng V.C.C. and Yuen K.Y., Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease, Journal of Infection. 2016, 72: 507-524.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

Researcher : Yu Z

List of Research Outputs

Yu Z., Tan Z., LEE B.K., TANG J., WU X., Cheung K.W., Lo N.T.L., Man K., Liu L. and Chen Z., Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget. 2015, 6(32): 32426-32438.

Researcher : Yuan S

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Yuan S, Kao RYT, Zhou J, Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	07/2015

List of Research Outputs

Researcher : Yuen K.Y.

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):	Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):	Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng VCC
Department:	Microbiology
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

List of Research Outputs

Researcher : Yuen KY

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):	Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):	Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng VCC
Department:	Microbiology
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016.

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N. and Yuen K.Y., Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors , Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Lau S.K.P., Wong S.C., To K.K.W., So S.Y., Leung S.S., Chan S.M., Pang C.M., Xiao C., Hung F.N.I., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis., Emerging Microbes and Infections. 2016, 5: e37.

Chan J.F.W., Chan K.H., Cai J., Tsang K.L., Markovitz D.M. and Yuen K.Y., BanLec Inhibits Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by Binding with the S1 Subunit of the Viral Spike Glycoprotein, 10th Asia-Pacific Congress of Medical Virology 2015.

Chan J.F.W., TSANG C.C., Yang J., Xing F., Leung S.M., Ngan A.H.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Trichomonascus (Candida) ciferrii isolates associated with granular myringitis, European Congress of Clinical Microbiology and Infectious Diseases, ECCMID 2016.

Chan J.F.W., Yip C.Y., Tee K.M., To K.K.W., Tang S.F. and Yuen K.Y., Comparison of a novel single-tube nested real-time PCR assay with FilmArray Respiratory Panel for detection of adenovirus, 32nd Clinical Virology Symposium. 2016.

Chan J.F.W., Tee K.M., Choi G.K.Y., Zhu Z., Poon W.S.R. and Yuen K.Y., Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction, 35th Annual Meeting of the American Society for Virology (ASV 2016), American Society for Virology. 2016.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development And Evaluation Of Novel Real-time Reverse Transcription Pcr Assays With Locked Nucleic Acid Probes Targeting Leader Sequences Of Human-pathogenic Coronaviruses., Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., CHOI K.Y., Tsang K.L., Tee K.M., Lam H.Y., Yip C.Y., To K.K.W., Cheng V.C.C., Yeung M.L., Lau S.K.P., Woo P.C.Y., Chan K.H., Tang B.S. and Yuen K.Y., Development and evaluation of novel real-time RT-PCR assays with locked nucleic acid probes targeting the leader sequences of human pathogenic coronaviruses, Journal of Clinical Microbiology. 2015, 53: 2722-2726.

Chan J.F.W., Chan T.S.Y., Singh G.H.H., Lam F.Y.F., Trendell-Smith N.J., Sridhar S., Tse H., Lau S.K.P., Hung I.F.N., Yuen K.Y. and Woo P.C.Y., Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors, Emerging Infectious Diseases. 2015, 21: 1101-1106.

Chan J.F.W., Chan K.H., Yeung M.L., To K.K.W., Markovitz D.M. and Yuen K.Y., Rediscovery of Banana Lectin (BanLec) as a Pan-coronavirus Antiviral: In Vitro & Ex Vivo evidence, 55th Interscience Conference on Antimicrobial Agents and Chemotherapy / 28th International Congress of Chemotherapy and Infection (ICAAC/ICC 2015). 2015.

Chan J.F.W., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients., Emerging Microbes And Infections. 2016, 5: e19.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chan J.F.W., Tee K.M., Choi G.K.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Urinary shedding pattern of polyomaviruses in patients with ketamine uropathy, 34th Annual Meeting of the American Society for Virology (ASV 2015), American Society for Virology. 2015.

Chan J.F.W., CHOI K.Y., Yip C.Y., Cheng V.C.C. and Yuen K.Y., Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease, Journal of Infection. 2016, 72: 507-524.

Chan T.C., Cheng V.C.C., Hung I.F.N., Chan F.H.W., Ng W.C. and Yuen K.Y., The Association Between Methicillin Resistant Staphylococcus aureus Colonization and Mortality in Chinese Nursing Home Older Adults: A 2-Year Prospective Cohort, Journal of the American Medical Directors Association. 2015, 16: 796-797.

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

Chen H.K.J., Cheng V.C.C., Wong O.Y., Wong S.C.Y., So S.Y.C., Yam W.C. and Yuen K.Y., The importance of matrix-assisted laser desorption ionization–time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar, Journal of Microbiology, Immunology and Infection. 2016.

Chen J.H.K., She K.K.K., Kwong T.C., Wong O.Y., Siu G.K.H., Leung C.C., Chang K.C., Tam C.M., Ho P.L., Cheng V.C.C., Yuen K.Y. and Yam W.C., Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1827-1832.

Cheng V.C.C., Chau P.H., So S.Y.C., Chen J.H.K., Poon R.W.S., Wong S.C.Y., Hung I.F.N., Lee W.M., Tai J.W.M., Ho P.L., Yam W.C. and Yuen K.Y., Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 1381-1386.

Cheng V.C.C., Chen J.H.K., Ng W.C., Wong J.Y.H., Chow M.K., Law T.C., So S.Y.C., Wong S.C.Y., Chan T.C., Chan F.H.W., Ho P.L. and Yuen K.Y., Emergence of Carbapenem-Resistant Acinetobacter baumannii in Nursing Homes With High Background Rates of MRSA Colonization, Infection Control & Hospital Epidemiology. 2016, 1-4.

Cheng V.C.C., Chau P.H., Lee W.M., Ho S.K.Y., Lee D.W.Y., So S.Y.C., Wong S.C.Y., Tai J.W.M. and Yuen K.Y., Hand-touch contact assessment of high-touch and mutual-touch surfaces among healthcare workers, patients, and visitors, Journal of Hospital Infection. 2015, 90: 220-225.

Cheng V.C.C., Chen H.K.J., Wong S.C.Y., Leung S.S., So S.Y., Lung D.C., Lee W.M., Trendell-Smith N.J., Chan W.M., Ng D., To L., Lie A.K.W. and Yuen K.Y., Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry, Clinical Infectious Diseases. 2016, 62: 714-721.

Cheng V.C.C., Tai J.W.M., Li W.S., Chau P.H., So S.Y.C., Wong L.M.W., Ching R.H.C., Ng M.M.L., Ho S.K.Y., Lee D.W.Y., Lee W.M., Wong S.C.Y. and Yuen K.Y., Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong, American Journal of Infection Control. 2016, 44: 621-624.

Cheng V.C.C., Lee W.M., Sridhar S., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong, Journal of Hospital Infection. 2015, 90: 355-356.

Cheng V.C.C., Tai J.W.M., Chau P.H., Lai C.K.C., Chuang V.W.M., So S.Y.C., Wong S.C.Y., Chen H.K.J., Ho P.L., Tsang D.N.C. and Yuen K.Y., Successful control of emerging vancomycin-resistant enterococci by territory-wide implementation of directly observed hand hygiene in patients in Hong Kong, American Journal of Infection Control. 2016.

Cheng V.C.C., Chen H.K.J., So S.Y.C., Wong S.C.Y., Yan M.K., Chau P.H., Lee W.M., To K.K.W., Chen H.K.J., Hung F.N.I., Ho P.L. and Yuen K.Y., Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 2359-2366.

Cheng V.C.C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Viral Infections, an Overview with a Focus on Prevention of Transmission, Reference Module in Biomedical Sciences. Elsevier Inc., 2015.

Cheung M.F.F., Tong Y., Wang Y., Cheung A.N.Y., Liu Y., Lau K.H.K., Wong K.K.Y., Lo S.K. and Yuen K.Y., Epstein-Barr virus-positive T-cell-associated colitis mimicking inflammatory bowel disease: clinicopathological study of two cases, In: Cheung FM, Tong Y, Wang Y, Cheung AN, Liu Y, Lau KK, Wong KK, Lo SK, Yuen KY., Histopathology. 2015, 465-8.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Dimiters S D., Jiang S.B., Ying T.L., Tseng K.C.T., Zhang L.Q. and Yuen K.Y., No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses, Proceedings of the National Academy of Sciences. 2015, 112: E5115-E5115.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Lau S.K.P., Tsang K.L., AHMED S.S., Mahbub A.M., Ahmed Z., Wong C.P., Yuen K.Y. and Woo P.C.Y., First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh., New Microbes and New Infection. 2016, 11: 54-56.

Lau S.K.P., Lee K.C., LO C.S., Ding S.Y., Chow W.N., Ke Y., Curreem S.O.T., To K.K.W., Ho T.Y., Sridhar S., Wong S.C., Chan J.F.W., Hung F.N.I., Sze K.H., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis., International Journal of Molecular Science. 2016, 17: 307.

Lau S.K.P., Lee K.C., Curreem S.O.T., Chow W.N., To K.K.W., Hung F.N.I., Ho D.T., Sridhar S., Li W.S., Ding S.Y., Koo E.W., Wong C.F., Tam S., Lam C.W., Yuen K.Y. and Woo P.C.Y., Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis., Journal of Clinical Microbiology. 2015, 53: 3750-3759.

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Chow W.N., Lau C.Y., Sridhar S., Wong S.C.Y., Martelli P., Hui S.W., Yuen K.Y. and Woo P.C.Y., Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway, Cell & Bioscience. 2015, 5.

Lau S.K.P., Feng Y., Chen H., LUK K.H., Yang W.H., Li K.S.M., Zhang Y.Z., Huang Y., Song Z.Z., Chow W.N., Fan Y.Y., AHMED S.S., Yeung C., Lam S.F., Cai J., Wong S.S.Y., Chan J.F.W., Yuen K.Y., Zhang H.L. and Woo P.C.Y., Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination., Journal of virology. 2015, 89: 10532-10547.

Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39.

Sridhar S., Wang A.Y.M., Chan J.F.W., Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil., Journal of Clinical Microbiology. 2015, 53: 3377-3379.

TSANG C.C., Hui T.W.S., Lee K.C., Chen J.H.K., Ngan A.H.Y., Tam W.T., Chan J.F.W., Wu L., Cheung M., Tse B.P.H., Wu A.K.L., Lai C.K.C., Tsang D.N.C., Que T.L., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing, Diagnostic Microbiology and Infectious Disease. 2016, 84: 125-134.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

To K.K.W., Zhou J., Chan J.F.W. and Yuen K.Y., Host genes and influenza pathogenesis in humans: an emerging paradigm, Current Opinion in Virology. 2015, 14: 7-15.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

To K.K.W., Lee K.C., Wong S.S.Y., Sze K.H., Ke Y., Lui Y.M., Tang B.S., Li W.S., Lau S.K.P., Hung F.N.I., Law C.Y., Lam C.W. and Yuen K.Y., Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia, Diagnostic Microbiology and Infectious Disease. 2016, 85: 249-254.

To K.K.W., Mok K.Y., Chan S.F., Cheung N.N., Wang P., Lui Y.M., Chan J.F.W., Chen H., Chan K.H., Kao R.Y.T. and Yuen K.Y., Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans, Journal of General Virology. 2016.

To K.K.W., Hung F.N.I., Lui Y.M., Mok K.Y., Chan S.F., Li T.W., Wong T.L., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study, Journal of Infection. 2016, 72: 207-213.

To K.K.W., Lau S.K.P., Chan K.H., Mok K.Y., Luk K.H., Yip C.Y., Ma Y.K., Sinn L.H., Lam S.H., Ngai C.W., Hung F.N.I., Chan K.H. and Yuen K.Y., Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients, Journal of Clinical Virology. 2016, 77: 85-91.

Wernery U., El Rasoul I.H., Wong Y.M., Joseph M., Chen Y., Jose S., Tsang K.L., Patteril N.A., Chen H., Elizabeth S.K., Yuen K.Y., Joseph S., Xia N., Wernery R., Lau S.K.P. and Woo P.C.Y., A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age., Emerging Microbes and Infections. 2015, 4: e74.

Wong S.S.Y., Poon R.W.S., Chau S., Wong S.C.Y., To K.K.W., Cheng V.C.C., Fung K.S.C. and Yuen K.Y., Development of Conventional and Real-Time Quantitative PCR Assays for Diagnosis and Monitoring of Scabies, Journal of Clinical Microbiology. 2015, 53: 2095-2102.

Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph S., Xie J., Jose S., Fan Y.Y., Wernery U. and Yuen K.Y., A novel astrovirus from dromedaries in the Middle East, Journal of General Virology. 2015, 96: 2697-2707.

Woo P.C.Y., Lau S.K.P., LI T., Jose S., Yip C.Y., Huang Y., Wong Y.M., Fan Y.Y., Cai J., Wernery U. and Yuen K.Y., A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East., Journal of General Virology. 2015, 96: 1723-1731.

Woo P.C.Y., Lau S.K.P., CHOI K.Y., Huang Y., Wernery R., Joseph S., Wong Y.M., Elizabeth S.K., Patteril N.A., Li T., Wernery U. and Yuen K.Y., Equine rhinitis B viruses in horse fecal samples from the Middle East., Virology Journal. 2016, 13: 94.

Woo P.C.Y., Lau S.K.P., Fan Y.Y., Lau C.Y., Wong Y.M., Joseph S., Tsang K.L., Wernery R., Yip C.Y., TSANG C.C., Wernery U. and Yuen K.Y., Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23, International Journal of Molecular Sciences. 2016, 17: 691.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yip C.Y., Lam S.F., Luk K.H., Wong Y.M., Lee R.A., So L.Y., Chan K.H., Cheng V.C.C., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong., Virologica Sinica. 2016, 31: 41-48.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

Zumla A., Chan J.F.W., Azhar E.I., Hui D.S. and Yuen K.Y., Coronaviruses — drug discovery and therapeutic options, Nature Reviews Drug Discovery. 2016, 15: 327-347.

Researcher : ZHANG N

List of Research Outputs

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Researcher : ZHAO S

List of Research Outputs

Lau S.K.P., Yip C.Y., ZHAO S., Chow W.N., To K.K.W., Wu A.K., Yuen K.Y. and Woo P.C.Y., Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong., Scientific Reports. 2016, 6: 25147.

Researcher : ZHENG M

List of Research Outputs

Chen H., Zheng M., Wang P., Song W., Lau S.Y., Mok B.W.Y., LIU S., HUANG X. and Yuen K.Y., Characterization and development of replication competent DelNS1 live attenuated influenza vaccine for cross protection of heterosubtype influenza virus inflection, Influenza Vaccines for The World-IVW 2015, 6-9 October, 2015 Albufeira, Algarve, Portugal . 2015.

ZHENG M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, Journal of Virology. 2015, 89: 10273-10285.

Zheng M., Wang P., Song W., Lau S.Y., LIU S., HUANG X., Mok B.W.Y., Liu Y., Chen Y., Yuen K.Y. and Chen H., An A14U Substitution in the 3= Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs, In: A. García-Sastre, Journal of Virology. 2015.

Researcher : Zhang GH

List of Research Outputs

VERHOEVEN R.J.A., TONG S., Zhang G.H. and Chen H., Regulation and functions of Epstein-Barr virus encoded miRNA and non-coding RNA in nasopharyngeal carcinoma, AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicine, December 4-7, 2015 in Boston, MA, USA. 2015.

Researcher : Zhang H

Project Title:	the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):	Zhang H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2011

Researcher : Zhang J

Project Title:	The expression and roles of functional leptin receptor (Ob-Rb) in proinflammatory responses induced by influenza viral infection.
Investigator(s):	Zhang J
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015
Completion Date:	12/2015

Project Title:	International Conference on Influenza; H7N9 influenza virus infection in BALB/c mouse induced impaired neutralizing antibody responses
Investigator(s):	Zhang J
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

Project Title:	Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):	Zhang J, To KKW, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., Li T.W., Wong T.L., ZHANG R., Chan T.C.I., Chan B.C., Wai H.H., Chan L.W., Fong H.P., Hui R.K., Kong K.L., Leung A.C., Ngan A.H., Tsang L.W., Yeung A.P., Yiu G.C., Yung W., Lau J.Y., Chen H., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial, The Lancet Infectious Diseases . 2016, 16(2): 209-18.

LEE C.Y., Zhu H., Zhang J., Li C., Wang P., Li C., Chen H., Hung F.N.I., To K.K.W. and Yuen K.Y., Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes , CLINICAL AND VACCINE IMMUNOLOGY. USA, AMER SOC MICROBIOLOGY, 2015, 22: 1235-1243.

To K.K.W., Lau C.Y., Woo P.C.Y., Lau S.K.P., Chan J.F.W., Chan K.H., Zhang J., Chen H. and Yuen K.Y., Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus, Virology Journal. 2016, 13.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Zhang JX

Project Title:	The expression and roles of functional leptin receptor (Ob-Rb) in proinflammatory responses induced by influenza viral infection.
Investigator(s):	Zhang J
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015
Completion Date:	12/2015

Project Title:	International Conference on Influenza; H7N9 influenza virus infection in BALB/c mouse induced impaired neutralizing antibody responses
Investigator(s):	Zhang J
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

Project Title:	Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):	Zhang J, To KKW, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Researcher : Zhang K

List of Research Outputs

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Zhang M

Project Title:	Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2011

Researcher : Zhao H

Project Title:	Anti-influenza virus study by generating defective virus using shortened viral genes
Investigator(s):	Zhao H, Zheng B
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014
Completion Date:	11/2015

Project Title:	17th International Conference on Virology and Infectious Diseases; A novel antiviral peptide showing universal effect against multiple viruses in vitro and in vivo
Investigator(s):	Zhao H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015
Completion Date:	09/2015

List of Research Outputs

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Zheng B

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2013

Project Title:	Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):	Zheng B, Chu H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	9th Global Summit and Expo on Vaccines & Vaccination; An H5N1 based matrix protein 2 ectodomain tetrameric peptide vaccine provided cross-protection against lethal infection of H7N9 influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015
Completion Date:	12/2015

List of Research Outputs

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

Shi L., Yu B., Cai C.H., Huang W., Zheng B., Smith D.K. and Huang J., Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release. 2016, 222: 130-140.

Wang X., Ma K., Chen M., Ko K.H., Zheng B. and Lu L., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection, PLoS Pathogens. 2016, 12: e1005367.

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Zheng B.

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2013

Project Title:	Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):	Zheng B, Chu H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	9th Global Summit and Expo on Vaccines & Vaccination; An H5N1 based matrix protein 2 ectodomain tetrameric peptide vaccine provided cross-protection against lethal infection of H7N9 influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015
Completion Date:	12/2015

List of Research Outputs

Researcher : Zheng M

List of Research Outputs

Researcher : Zhou J

Project Title:	A cell-based model to uncover the molecular underpinning of differential susceptibility and variable severity of human H7N9 influenza infection
Investigator(s):	Zhou J, Song Y, To KKW
Department:	Microbiology
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	08/2014

Project Title:	Characterization of the immune activation pathway in human macrophage and the macrophage-neutrophil interaction in MERS coronavirus infection
Investigator(s):	Zhou J, Jin D, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	International conference on influenza; Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) influenza and A(H7N9) influenza
Investigator(s):	Zhou J
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2015
Completion Date:	08/2015

List of Research Outputs

CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302.

Chan J.F.W., Yao Y., Yeung M.L., Deng W., Bao L., Jia L., Li F., Xiao C., Gao H., Yu P., Cai J., Chu H., Zhou J., Chen H., Qin C. and Yuen K.Y., Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset, Journal of Infectious Diseases. 2015, 212: 1904-1913.

Chu H., Zhou J., Wong H.Y.B., Li C., Chan J.F.W., Cheng Z., Yang D., Wang D., Lee C.Y., Li C., Yeung M.L., Cai J., Chan H.Y.I., Ho W.K., To K.K.W., Zheng B., Yao Y., Qin C. and Yuen K.Y., Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways, Journal of Infectious Diseases. 2016, 213: 904-914.

To K.K.W., Zhou J., Chan J.F.W. and Yuen K.Y., Host genes and influenza pathogenesis in humans: an emerging paradigm, Current Opinion in Virology. 2015, 14: 7-15.

YUAN S., ZHANG N., SINGH K., SHUAI H., Chu H., Zhou J., Chow B.K.C. and Zheng B., Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain, Antimicrobial Agents and Chemotherapy. 2015, 59: 4082-4093.

Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004.

Yuan S., Chu H., SINGH K., Zhao H., Zhang K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase, Scientific Reports. 2016, 6: 22880.

Yuan S., Chu H., Zhao H., Zhang K., SINGH K., Chow B.K.C., Kao R.Y.T., Zhou J. and Zheng B., Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase, Antiviral Research. 2016, 125: 34-42.

Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008.

Researcher : Zhu H

Project Title:	Evolution and Risk assessment studies for 2009 pandemic-like reassortant swine influenza viruses from China
Investigator(s):	Zhu H, Guan Y, Smith DK
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012
Completion Date:	10/2015

Project Title:	Transmissibility and pathogenicity studies of the recent H7N9 human and avian isolates in a ferret model
Investigator(s):	Zhu H, Guan Y
Department:	School of Public Health
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	06/2014
Completion Date:	03/2016

Project Title:	Molecular basis for the infectivity and transmissibility of the human isolated A(H7N9) influenza virus in a ferret model
Investigator(s):	Zhu H, Guan Y
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Zhu H
Department:	School of Public Health
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2014

Project Title:	Molecular determinants for the interspecies transmission of an avian H6N1 virus that caused the human infection in Taiwan
Investigator(s):	Zhu H, Guan Y
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Continuous evolution of H10N8 influenza viruses in chickens and molecular determinants for their infectivity in mammals
Investigator(s):	Zhu H, Guan Y, Lam TY
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

List of Research Outputs

Guan Y. and Zhu H., Development of the H7N9 influenza virus in China and risk assessment of the multiple genotypes., CEIRS 1st Annual Network Meeting & CEIRS Surveillance Meeting. 2015.

Guan Y. and Zhu H., Dissemination and development of the H7N9 influenza viruses in China , 11th National Virology Conference and the 6th Wuhan International Symposium on Modern Virology. 2015.

Zhu H., Application of the Next Generation Sequencing technique in the research on diagnosis, source-tracing and evolution of emerging viral diseases , Guangdong Provincial Continuing Education Program on High Throughput Sequencing and Clinical Diagnosis. 2015.

Zhu H., Avian Influenza Viruses in China. , USAID/FAO Regional Technical Consultation on Zoonotic Influenza Surveillance in Asia. . 2015.

Zhu H., Ecology, evolution and interspecies transmission of influenza A viruses -an update on the avian and swine influenza. , Control of Pandemic and Inter-pandemic Influenza: Area of Excellence Annual Progress Report Meeting. 2015.

Zhu H., Emergence and Development of H7N9 and H10N8 Influenza Viruses in China. , Illumina Hong Kong User Meeting. 2015.

Zhu H., Newcastle Disease Virus (NDV) and Oncolytic Therapy, Shantou University Medical College. 2015.

Zhu H., Oncolytic Viruses for Cancer Diagnosis and Therapy., Top-tier University Development Scheme Seminar. Shantou University Medical College. 2015.

Zhu H., Surveillance at the Animal-human Interface and Large-scale Sequencing of Pathogens in Response to Public Health Emergency. , 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015). 2015.

Researcher : Zhu Z

List of Research Outputs

Chan J.F.W., Tee K.M., Choi G.K.Y., Zhu Z., Poon W.S.R. and Yuen K.Y., Detection of human polyomavirus 6 in the bile samples of patients with malignant biliary obstruction, 35th Annual Meeting of the American Society for Virology (ASV 2016), American Society for Virology. 2016.

Tee K.M., Choi G.K.Y., Poon W.S.R., Zhu Z., Chan K.H., Yuen K.Y. and Chan J.F.W., Detection of Human Polyomavirus 6 in the Bile Samples of Patients with Acute Gallstone Cholangitis, 32nd Clinical Virology Symposium. 2016.

Zhu Z., Chan J.F.W., Tee K.M., CHOI K.Y., Lau S.K.P., Woo P.C.Y., Tse H. and Yuen K.Y., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic., Emerging Microbes and Infections. 2016, 5: e22.

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