DEPT OF BIOCHEMISTRY
| Researcher : Au YK |
| List of Research Outputs |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., Collagen Microspheres - A Three-Dimensional Culture System for Notochordal Cells, Global Spine Congress & World Forum for Spine Research 2016. |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., development of 3D system for culturing notochordal cells, 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the evolution of Regenerative Medicine. 8-11 September 2015, Boston, MA, USA. 2015. |
| Researcher : Bao S |
| Project Title: | Prioritizing genes from runs of homozygosity associated with Alzheimer's disease by combined analysis of rare variants and gene networks |
| Investigator(s): | Bao S, Song Y, Zhou X |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| Researcher : Boyde TRC |
| List of Research Outputs |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2015. |
| Researcher : Chan CH |
| List of Research Outputs |
| Lam C.L.D., Chan C.H., Mak J.C.W., Freeman C., Ip M.S.M. and Shum D.K.Y., S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation., Scientific Reports. 2015, 5: 12945. |
| Lau K.W., CUI Y., Chan C.H., Ip M.S.M. and Mak J.C.W., The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation, Free Radical Research. 2016, 50: 495-502. |
| Researcher : Chan CP |
| Project Title: | Roles of liver-enriched transcription factor CREB-H in liver fibrosis |
| Investigator(s): | Chan CP, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Regulation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferase |
| Investigator(s): | Chan CP, Zhou J |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Project Title: | Characterization of a novel b-TrCP ubiquitin ligase-dependent mechanism for ubiquitination and degradation of liver-enriched transcription factor CREB-H |
| Investigator(s): | Chan CP, Yuen KS, Lui PY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - Science Fund for Young Scholars |
| Start Date: | 01/2016 |
| Project Title: | Antiviral activity of cGAS/cGAMP against RNA virus infection |
| Investigator(s): | Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | The American Association of Immunologists annual meeting 2016; Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response |
| Investigator(s): | Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| List of Research Outputs |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 08/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Kudelko M.A., Chan C.W., Sharma R., Yao Q., Lau E., Chu I.K., Cheah K.S.E., Tanner J.A. and Chan D., Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress, J Proteome Res. 2016, 15(1): 86-99. |
| LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of 3D culture system for bovine nucleus pulposus cells, 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the evolution of Regenerative Medicine. 8-11 September 2015, Boston, MA, USA. 2015. |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., Collagen Microspheres - A Three-Dimensional Culture System for Notochordal Cells, Global Spine Congress & World Forum for Spine Research 2016. |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., development of 3D system for culturing notochordal cells, 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the evolution of Regenerative Medicine. 8-11 September 2015, Boston, MA, USA. 2015. |
| Researcher : Chan D. |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 08/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Researcher : Chan JKM |
| Project Title: | Establishment of novel approaches to the study of the role of histone post-translational modifications in vivo |
| Investigator(s): | Chan KMJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Epigenetics, Chromatin & Transcription; Epigenetics / Histone mutations in Human Disease |
| Investigator(s): | Chan KMJ |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2014 |
| Project Title: | Functional analysis of the role of Mcm3 in epigenetic gene silencing |
| Investigator(s): | Chan KMJ |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Researcher : Chan WCW |
| Project Title: | Understanding the Differentiation of Inner Annulus Fibrosus Cells: An in vitro Approach |
| Investigator(s): | Chan WCW, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Project Title: | Global Spine Congress/ World Forum for Spine Research 2016; Contribution of Hypertrophic Chondrocytes to the Homeostasis of Annulus Fibrosis in normal and degenerative intervertebral discs |
| Investigator(s): | Chan WCW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| Researcher : Cheah K.S.E. |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem cells: Niches, Regeneration & Repair |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 03/2013 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| List of Research Outputs |
| Researcher : Cheah KSE |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem cells: Niches, Regeneration & Repair |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 03/2013 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| List of Research Outputs |
| Kudelko M.A., Chan C.W., Sharma R., Yao Q., Lau E., Chu I.K., Cheah K.S.E., Tanner J.A. and Chan D., Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress, J Proteome Res. 2016, 15(1): 86-99. |
| LAU K.S., TANG H.L., Chung M.F., Tsang K.Y., CHAN C.S., Wei X., Wong K.K.Y., Lam E.Y.M., Cheah K.S.E., Shum H.C. and Tsia K.K.M., Quantitative asymmetric-detection time-stretch optical microscopy (Q-ATOM) for ultrafast quantitative phase imaging flow cytometry, Photonics West, San Francisco, CA, USA, paper 9720-33, Feb. 2016. 9720-33. |
| LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of 3D culture system for bovine nucleus pulposus cells, 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the evolution of Regenerative Medicine. 8-11 September 2015, Boston, MA, USA. 2015. |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., Collagen Microspheres - A Three-Dimensional Culture System for Notochordal Cells, Global Spine Congress & World Forum for Spine Research 2016. |
| Yuan M., Yeung C.W., Au Y.K., Chan D., Cheah K.S.E. and Chan B.P., development of 3D system for culturing notochordal cells, 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the evolution of Regenerative Medicine. 8-11 September 2015, Boston, MA, USA. 2015. |
| Researcher : Cheng LYL |
| Project Title: | A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community |
| Investigator(s): | Cheng LYL, Tan-Un KC |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Researcher : Cheung YW |
| Project Title: | APTAMERS in Bordeaux; An Aptamer-Based Diagnostic Test Specific for Falciparum Malaria |
| Investigator(s): | Cheung YW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |
| List of Research Outputs |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| Researcher : Fu C |
| Project Title: | Systematic investigation of the roles of mitotic kinesins in spindle dynamics |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Roles of a novel spindle pole body protein psr1p in bipolar spindle assembly and kinetochore clustering |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 12/2013 |
| Completion Date: | 12/2015 |
| Project Title: | The role of Cdk1 mediated phosphorylation of the CENP-A chaperone Scm3p in mitosis |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Molecular mechanisms of nuclear congression |
| Investigator(s): | Fu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| HUI T.H., Zheng F., Lin Y. and Fu C., The linear and rotational motions of the fission yeast nucleus are governed by the stochastic dynamics of spatially distributed microtubules, Journal of Biomechanics. 2016, 49: 1034-1041. |
| ZHU Q., Fu C. and Lin Y., Shape transformation of the nuclear envelope during closed mitosis, The Chinese Congress of Theoretical and Applied Mechanics (CCTAM 2015), Shanghai, China, August 15-18. 2015. |
| Researcher : GAO W |
| List of Research Outputs |
| LEUNG K.C., Lo I., Luk H.M., Tang H.M.V., Gao W., Wong W.L., Chu W.Y., Lam S.T.S., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Chinese patients with rasopathies: Detection of 29 known and novel variants using next-generation sequencing (NGS), 2015 David W. Smith Workshop on Malformations and Morphogenesis, USA, August 2015. 91. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Researcher : Gao B |
| Project Title: | Characterize the in vivo functional significance of Vangl2 phosphorylation in Planar Cell Polarity (PCP) |
| Investigator(s): | Gao B |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | 中國生理學會基質生物學專業委員會成立大會 暨第一次全國基質生物學學術會議; Global Directional Cues in Establishing Planar Cell Polarity During Long Bone Development |
| Investigator(s): | Gao B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2016 |
| Completion Date: | 03/2016 |
| Project Title: | Identifying the genetic variants underlying carpal tunnel syndrome in a big family |
| Investigator(s): | Gao B, Song Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Researcher : Gao W |
| List of Research Outputs |
| LEUNG K.C., Lo I., Luk H.M., Tang H.M.V., Gao W., Wong W.L., Chu W.Y., Lam S.T.S., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Chinese patients with rasopathies: Detection of 29 known and novel variants using next-generation sequencing (NGS), 2015 David W. Smith Workshop on Malformations and Morphogenesis, USA, August 2015. 91. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Researcher : Guo S |
| Project Title: | 47th Annual Meeting for the Japanese Society of Developmental Biologists; Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse |
| Investigator(s): | Guo S |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2014 |
| Researcher : HO TH |
| List of Research Outputs |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| Researcher : Huang J |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Role of kinesin-1 in NMDAR trafficking and cerebral ischemia |
| Investigator(s): | Huang J, Lin R |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Completion Date: | 11/2015 |
| Project Title: | Guiding the immune response: a novel approach for HIV-1 vaccine development |
| Investigator(s): | Huang J, Zhang M |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Biochemical and biophysical characterization of Kif5b cargo binding domain |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2015 |
| Project Title: | the 9th Vaccine & ISV Congress; Recombinant ESAT‐6‐like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration |
| Investigator(s): | Huang J, Sze KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Researcher Award 2014-15 |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Salmonella-induced host innate immunity against cancer metastasis |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Huang J. |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Role of kinesin-1 in NMDAR trafficking and cerebral ischemia |
| Investigator(s): | Huang J, Lin R |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Completion Date: | 11/2015 |
| Project Title: | Guiding the immune response: a novel approach for HIV-1 vaccine development |
| Investigator(s): | Huang J, Zhang M |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Biochemical and biophysical characterization of Kif5b cargo binding domain |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2015 |
| Project Title: | the 9th Vaccine & ISV Congress; Recombinant ESAT‐6‐like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration |
| Investigator(s): | Huang J, Sze KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Researcher Award 2014-15 |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Salmonella-induced host innate immunity against cancer metastasis |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Huang W |
| List of Research Outputs |
| Shi L., Yu B., Cai C.H., Huang W., Zheng B., Smith D.K. and Huang J., Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release. 2016, 222: 130-140. |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Completion Date: | 08/2015 |
| Project Title: | Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells |
| Investigator(s): | Jin D, Huang J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 06/2016 |
| Project Title: | Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription |
| Investigator(s): | Jin D, Zheng B, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Roles of SIRT1 deacetylase in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Ching YP, Tu W |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 12/2015 |
| Project Title: | Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription |
| Investigator(s): | Jin D, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Mechanism of inflammasome activation by SARS coronavirus 3a protein |
| Investigator(s): | Jin D, Zheng B, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Characterization of a novel cGAMP-hydrolyzing phosphodiesterase encoded by Middle East respiratory syndrome coronavirus |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Outstanding Research Student Supervisor Award 2013-14 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2014 |
| Project Title: | Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Novel regulatory mechanisms in RIG-I-dependent innate antiviral response |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2015 |
| Completion Date: | 01/2016 |
| Project Title: | Characterization of a novel β-TrCP-dependent pathway for ubiquitination and degradation of liver-enriched transcription factor CREB-H |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein |
| Investigator(s): | Jin D, Yeung ML |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | American Society for Virology 34th Annual Meeting; Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Project Title: | Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response |
| Investigator(s): | Jin D, Yang W, Deng J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2016 |
| Project Title: | Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases |
| Investigator(s): | Jin D, Deng J, Kong KY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Molecular Mechanism of PACT-dependent Innate Antiviral Response |
| Investigator(s): | Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| LEUNG K.C., Lo I., Luk H.M., Tang H.M.V., Gao W., Wong W.L., Chu W.Y., Lam S.T.S., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Chinese patients with rasopathies: Detection of 29 known and novel variants using next-generation sequencing (NGS), 2015 David W. Smith Workshop on Malformations and Morphogenesis, USA, August 2015. 91. |
| Lui P.Y., Jin D. and Stevenson N.J., MicroRNA: master controllers of intracellular signaling pathways, Cellular and Molecular Life Sciences. 2015, 72: 3531-3542. |
| Yeung M.L., Yao Y., Jia L., Chan J.F.W., Chan K.H., Cheung K.F., Chen H., Poon K.M., Tsang K.L., To K.K.W., Yiu M.K., Teng L.L., Chu H., Zhou J., Zhang Q., Deng W., Lau S.K.P., Lau J.Y., Woo P.C.Y., Chan D.T.M., Yung S.S.Y., Zheng B., Jin D., Mathieson P.W., Qin C. and Yuen K.Y., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2, Nature Microbiology. 2016, 1: 16004. |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| Zhao H., Zhou J., Zhang K., Chu H., Liu D., Poon K.M., Chan C.S., Leung H.C., Ng F., Lin Y.P., Zhang J., Jin D., Yuen K.Y. and Zheng B., A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses, Scientific Reports. 2016, 6: 22008. |
| Researcher : KEW C |
| List of Research Outputs |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015. |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Researcher : Kok KH |
| Project Title: | Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis |
| Investigator(s): | Kok KH, Wong CM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity |
| Investigator(s): | Kok KH, Chan CP |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Role of PACT in host antiviral defence against influenza A virus |
| Investigator(s): | Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Characterization of an alternatively spliced tumor suppressor FAT1 in hepatocellular carcinoma |
| Investigator(s): | Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Suppression of PACT-dependent antiviral response by measles virus V protein |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Innate immune sensing of rotavirus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | Functional role of PACT in limiting replication of influenza A virus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2016 |
| Project Title: | The 35th annual meeting of the American Society for Virology; Loss of immunostimulative property of Sendai virus-derived defective-interfering RNA by adenosine-to-inosine editing |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |
| Researcher : Kudelko MA |
| List of Research Outputs |
| Kudelko M.A., Chan C.W., Sharma R., Yao Q., Lau E., Chu I.K., Cheah K.S.E., Tanner J.A. and Chan D., Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress, J Proteome Res. 2016, 15(1): 86-99. |
| Researcher : LI J |
| List of Research Outputs |
| Xiao B., Gu S.M., LI J., Li J., Tao B., Wang Y., Wang J.J., Li B., Patrignani P. and Yu Y., Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population, Arteriosclerosis, Thrombosis, and Vascular Biology. 2015, 35: 1687-1695. |
| Researcher : LUI PY |
| List of Research Outputs |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Lui P.Y., Jin D. and Stevenson N.J., MicroRNA: master controllers of intracellular signaling pathways, Cellular and Molecular Life Sciences. 2015, 72: 3531-3542. |
| Researcher : Lam VMS |
| Project Title: | 18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Project Title: | 7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2003 |
| Researcher : Lei T |
| Project Title: | A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis |
| Investigator(s): | Lei T, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| Researcher : Liu B |
| Project Title: | Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice |
| Investigator(s): | Liu B, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2008 |
| Project Title: | Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2009 |
| Project Title: | Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets |
| Investigator(s): | Liu B, Zhou Z, Chu IK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2012 |
| Project Title: | Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| Researcher : Lui PY |
| List of Research Outputs |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Lui P.Y., Jin D. and Stevenson N.J., MicroRNA: master controllers of intracellular signaling pathways, Cellular and Molecular Life Sciences. 2015, 72: 3531-3542. |
| Researcher : Ng RK |
| Project Title: | The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia |
| Investigator(s): | Ng RK, Yiu SM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Dysregulation of DNA methylation in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | The role of BMI-1 in regulation of JAK-STAT signaling pathway in human leukemia |
| Investigator(s): | Ng RK, Yiu SM |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Epigenetic regulation of enhancer RNA in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Ni Y |
| Project Title: | Three-Dimensional Super-Resolution Visualization of specific non-repetitive DNA in Single Mammalian Cells |
| Investigator(s): | Ni Y, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Researcher : Niu B |
| Project Title: | Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate |
| Investigator(s): | Niu B, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Researcher : Pang H |
| List of Research Outputs |
| Crawford R.J., Ni Mhuiris A., Cheung J.P.Y., Bow H.Y.C., Pang H., Elliott J.M., Karppinen J., Melloh M., Luk K.D.K., Cheung K.M.C. and Samartzis D., Lumbar paravertebral muscle fatty infiltration: spatial distribution and association with disc degeneration in an Asian population, Spineweek 2016, Singapore, May 16-20, 2016. |
| Pang H., Hui E., Bow H.Y.C., Cheung J.P.Y., Borthakur A., Karppinen J., Inoue N., Wang H.Q., Luk K.D.K., Cheung K.M.C. and Samartzis D., The UTE MRI disc sign (UDS): a novel imaging biomarker associated with spine degeneration, pain and disability, Spineweek 2016, Singapore, May 16-20, 2016. |
| Researcher : Qian C |
| Project Title: | Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Completion Date: | 12/2015 |
| Project Title: | Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | Structural & Mechanistic Analysis of BAF Chromatin Remodeling Complex |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2015 |
| Project Title: | the 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription; Timeless interacts with PARP-1 to promote DNA Double-strand Break repair |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| Project Title: | Structural and Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Aguilo F., Li S., Balasubramaniyan N., Sancho A., Benko S., Zhang F., Vashisht A., Rengasamy M., Andino B., Chen C., Zhou F., Qian C., Zhou M...M..., Wohlschlegel J...A..., Zhang W., Such F...J... and Walsh M...J..., Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α, Cell Reports. 2016, 14: 479-492. |
| Researcher : Qin J |
| Project Title: | Prediction of determining factors and underlying networks for cell conversion by integrating ChIP-seq/chip and transcriptome data |
| Investigator(s): | Qin J, Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 02/2016 |
| Researcher : Samartzis D |
| Project Title: | The Role of Schmorl's Nodes in Lumbar Intervertebral Disc Degeneration |
| Investigator(s): | Samartzis D, Anthony M, Chan T, Cheung KMC, Luk KDK, Wu EX |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | Spineweek 2012 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING OF NORMAL AND DEGENERATIVE LUMBAR INTERVERTEBRAL DISCS "CLINICAL TRIAD" MANIFESTATIONS IN THE KLIPPEL-FEIL PATIENT AND THE ASSOCIATION WITH CONGENITALLY FUSED CERVICAL SEGMENTS A LARGE-SCALE POPULATION-BASED STUDY OF MODIC CHANGES OF THE LUMBAR SPINE CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) AND T2 MAPPING IN SUBJECTS WITH INTERVERTEBRAL DISC DEGENERATION BASELINE MRI CHARACTERISTICS IN ASYMPTOMATIC SUBJECTS AS PREDICTORS FOR FUTURE FIRST-TIME LBP EPISODE |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2012 |
| Project Title: | The Role of Ionizing Radiation Exposure in the Development of Intervertebral Disc Degeneration of the Lumbar Spine: a Prospective, Longitudinal Study |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Project Title: | The Role of Adipokines in Intervertebral Disc Degeneration of the Lumbar Spine |
| Investigator(s): | Samartzis D, Chan D, Cheung BMY, Cheung KMC, Leung VYL, Luk KDK, Wang Y |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | 40th Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS); SERUM METABOLOMIC BIOMARKERS AND LUMBAR DISC DEGENERATION /EPIDEMIOLOGY, DETERMINANTS, AND FUNCTIONAL STATUS OF SCIATICA: A LARGE-SCALE POPULATION-BASED STUDY IN CHINESE /THE SAFETY AND EFFICACY OF MESENCHYMAL STEM CELLS FOR PREVENTION OR REGENERATION OF INTERVERTEBRAL DISC DEGENERATION: A SYSTEMATIC REVIEW /FACET JOINT TROPISM AND DEGENERATIVE SPONDYLOLISTHESIS – A STUDY FROM THE AOSAP RESEARCH COLLABORATION |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2013 |
| Project Title: | Metabonomics of Intervertebral Disc Degeneration |
| Investigator(s): | Samartzis D, Chan D, Luk KDK, Cheung KMC |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | 41st Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS); Prediction of future first-time low back pain based on baseline MRI findings/Body Mass Index and its Association with Lumbar Disc Herniation and Sciatica: a Large-Scale, Population-Based Study/A large‐scale study of Modic changes in the lumbar spine: morphology and association with MRI phenotypes |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| Project Title: | Pain perception in relation to disc degeneration and low back pain |
| Investigator(s): | Samartzis D, Cheung KMC, Bow HYC, Cheung CW |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Modic Changes of the Lumbar Spine |
| Investigator(s): | Samartzis D, Luk KDK, Cheung KMC, Hui SK |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Project Title: | 42nd Annual ISSLS Annual Meeting; UTE MRI Disc Sign (UDS): a novel imaging biomarker associated with spine degeneration, pain and disability/"Proteoglycan profile" and level-specific imaging biomarkers of lumbar disc displacement/The association of Modic changes and disabling low back pain: a large-scale, population-based study/Ciculating CCL5/RANTES: a potential biomarker for human intervertebral disc degeneration/A novel pathway associated with lumbar disc degeneration: a genome-wide association study |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Project Title: | SpineWeek 2016; Natural history of lumbar disc degeneration and other spinal phenotypes on MRI: A prospective, comparative five-year longitudinal study/Family history of low back pain is a significant predictor of pain and disability between extreme stages of lumbar disc degeneration |
| Investigator(s): | Samartzis D |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Project Title: | The safety and efficacy of Zoledronic acid for the treatment of chronic low back pain due to Modic changes: a parallel, double-blinded, randomized controlled trial |
| Investigator(s): | Samartzis D, Karppinen JI, Luk KDK, Cheung KMC, Cheung JPY |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Samartzis D., Editor, British Medical Journal. 2016. |
| Samartzis D., Editor, Spine. 2016. |
| Researcher : Sham MH |
| Project Title: | International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2000 |
| Project Title: | Outstanding Research Student Supervisor Award 2008-2009 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2009 |
| Project Title: | Visiting Research Professors Scheme 2010-11 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2010 |
| Project Title: | The roles of Irx3 and Irx5 genes in mammalian inner ear morphogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Modulation of Notch1 receptor Intracellular Domain (NICD) stability by Eya1 phosphatase |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Modulation of Notch Signaling by EYA1 in Breast Cancer |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| LIU A., Lai P.L., GUI H., Sham M.H., Tam P.K.H., Garcia-Barcelo M.M., Hui C.C. and Ngan E.S.W., Identification of GLI mutations in patients with Hirschsprung disease that disrupt enteric nervous system development in mice, Gastroenterology. 2015, 149(7): 1837-1848. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Neuroscience 2015; Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| List of Research Outputs |
| Lai C.H., Ma C.W., Lai S.K., Han L., Wong H.M., Yeung K.W.K., Shum D.K.Y. and Chan Y.S., Maturation of glutamatergic transmission in the vestibulo-olivary pathway impacts on the registration of head rotational signals in the brainstem of rats, Brain Structure and Function. 2016, 221: 217-238. |
| Researcher : Siu KL |
| List of Research Outputs |
| Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015. |
| WANG P., Siu K.L., ZHANG Y., Yang W. and Kok K.H., A novel transcript isoform of STING that suppresses innate antiviral response, The American Society for Virology 34th Annual Meeting. 2015. |
| Researcher : Smith DK |
| Project Title: | Patterns in proteins with unusual flexibility profiles |
| Investigator(s): | Smith DK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 08/2002 |
| Researcher : Song Y |
| Project Title: | A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice |
| Investigator(s): | Song Y, Cheah KSE, Sham PC |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese |
| Investigator(s): | Song Y, Sham PC, Fan Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | The role of hnrnpa1 in human congenital heart defects |
| Investigator(s): | Song Y, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 10/2015 |
| Project Title: | Repurposing the approved drugs for prevention and treatment of Alzheimer’s disease in transgenic mouse models |
| Investigator(s): | Song Y, Chu LW |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2014 |
| Completion Date: | 12/2015 |
| Project Title: | Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study |
| Investigator(s): | Song Y, Yeung ML, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 10/2014 |
| Project Title: | Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS) |
| Investigator(s): | Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Study of the pathogenic mechanisms of Hnrnpa1 in congenital heart defects (CHD) |
| Investigator(s): | Song Y, Lian Q, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Investigation of the roles of HNRNPA1 in the maintenance of motor neurons |
| Investigator(s): | Song Y, Cheung MCH, Ho WL, Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2016 |
| List of Research Outputs |
| LI J., Sham P.C., Song Y. and Li M., SPS: A Simulation Tool for Calculating Power of Set-Based Genetic Association Tests, Genetic Epidemiology. 2015, 39: 395-397. |
| Researcher : Szeto YY |
| Project Title: | Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear |
| Investigator(s): | Szeto YY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Researcher : Tai CP |
| Project Title: | Conservation of chordate SOXE protein function in chondrogenesis |
| Investigator(s): | Tai CP, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2012 |
| Completion Date: | 02/2016 |
| Researcher : Tam JWO |
| Project Title: | 14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis |
| Investigator(s): | Tam JWO |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Researcher : Tam V |
| Project Title: | Understanding the role of clusterin in intervertebral disc degeneration |
| Investigator(s): | Tam V, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cheung J.P.Y., Cheung W.H.P., Samartzis D., Tam V., Leung V.Y.L. and Cheung K.M.C., Significance of ligamentum flavum hypertrophy in developmental spinal stenosis, 36th SICOT Orthopaedic World Congress. Guangzhou, China, 2015. |
| Cheung W.H.P., Cheung J.P.Y., Tam V., Leung V.Y.L., Samartzis D. and Cheung K.M.C., The Relationship of Ligamentum Flavum Changes and Developmental Spinal Stenosis, 35th Hong Kong Orthopaedic Association Annual Congress. 2015. |
| Researcher : Tang HMV |
| List of Research Outputs |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| LEUNG K.C., Lo I., Luk H.M., Tang H.M.V., Gao W., Wong W.L., Chu W.Y., Lam S.T.S., Ma C.H., Jin D., Chan Y.K. and Chung B.H.Y., Chinese patients with rasopathies: Detection of 29 known and novel variants using next-generation sequencing (NGS), 2015 David W. Smith Workshop on Malformations and Morphogenesis, USA, August 2015. 91. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Researcher : Tanner J.A. |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Tetrapod Palindromic Capture Aptamers for Diagnostic Devices |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Project Title: | FEBS 2015; DNA aptamers for malaria diagnosis - from crystal structure to clinical application/Long-Chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles /Developing scientific writing and integrating feedback for undergraduate biomedical students through mimicking the professional journal article review process |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Project Title: | DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Researcher : Tanner JA |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Tetrapod Palindromic Capture Aptamers for Diagnostic Devices |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Project Title: | FEBS 2015; DNA aptamers for malaria diagnosis - from crystal structure to clinical application/Long-Chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles /Developing scientific writing and integrating feedback for undergraduate biomedical students through mimicking the professional journal article review process |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Project Title: | DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Kudelko M.A., Chan C.W., Sharma R., Yao Q., Lau E., Chu I.K., Cheah K.S.E., Tanner J.A. and Chan D., Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress, J Proteome Res. 2016, 15(1): 86-99. |
| Researcher : Tsang KY |
| Project Title: | Stress Proteins in Growth, Development & Disease Gordon Research Conference; Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice |
| Investigator(s): | Tsang KY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Researcher : Tsang SW |
| Project Title: | Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo |
| Investigator(s): | Tsang SW, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| Researcher : Wang C |
| Project Title: | Stress Proteins in Growth, Development & Disease; The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21 |
| Investigator(s): | Wang C |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Researcher : Wang J |
| List of Research Outputs |
| Poon M.W., He J., Fang X., Zhang Z., Wang W., Wang J., Qiu F., Tse H.F., Li W., Liu Z. and Lian Q., Human ocular epithelial cells endogenously expressing SOX2 and OCT4 yield high efficiency of pluripotency reprogramming, PLOS One. 2015, 10(7): e0131288. |
| Researcher : Wang JJ |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | ISMB/ECCB 2015 / NetBio SIG 2015; Prediction of determining factors and underlying gene regulatory network for cell fate conversion |
| Investigator(s): | Wang JJ |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K., Wang J.J. and Sun H., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2015. |
| WANG Y., TSANG C.N., XU F., KONG P.K., Hu L., Wang J.J., Chu I.K., Li H. and Sun H., Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography, Chemical Communications. RSC, 2015, 51. |
| Zhu Y., Qin J., Wong M.P. and Wang J.J., The role of FOXM1 and Kaiso in Non-small-cell lung carcinoma (NSCLC), The 23rd Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and the 12th Annual European Conference on Computational Biology (ECCB), Dublin, Ireland, 10-14 July 2015.. 2015. |
| Researcher : Wong EYM |
| Project Title: | The role of Six1 in controlling the microtubule polymerization during inner ear hair cell bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | Genetic analyses of Cdo and Boc function in inner ear development |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Functional characterization of Six1 on inner ear hair cell ciliary bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2015 |
| Researcher : Wong NS |
| Project Title: | Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol |
| Investigator(s): | Wong NS, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2002 |
| Project Title: | The relatioship between glycolysis and gluconeogenesis in cancer cells |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | Cellular stress responses in cancer cells with impaired glycogen metabolism |
| Investigator(s): | Wong NS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Wong XHL |
| Project Title: | The Biological Functions of MT1-MMP in Lymphatic Vascular Development |
| Investigator(s): | Wong HLX, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2015 |
| Completion Date: | 10/2015 |
| Researcher : Wong YME |
| Project Title: | The role of Six1 in controlling the microtubule polymerization during inner ear hair cell bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | Genetic analyses of Cdo and Boc function in inner ear development |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Functional characterization of Six1 on inner ear hair cell ciliary bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2015 |
| Researcher : Xu F |
| List of Research Outputs |
| WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K., Wang J.J. and Sun H., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2015. |
| WANG Y., TSANG C.N., XU F., KONG P.K., Hu L., Wang J.J., Chu I.K., Li H. and Sun H., Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography, Chemical Communications. RSC, 2015, 51. |
| Researcher : Yao KM |
| Project Title: | Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2007 |
| Project Title: | Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Secreted PDZ domain-containing protein 2 and regulation of Sonic hedgehog signaling during neural tube development |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion |
| Investigator(s): | Yao KM, Chan DW |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Project Title: | Identifying the cognate receptor of secreted PDZD2 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | Investigating the signalling function of secreted PDZD2 |
| Investigator(s): | Yao KM, Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 08/2015 |
| Researcher : Yu B |
| Project Title: | Study of LPS effect in Salmonella-tumor interactions by using intravital imaging in vivo |
| Investigator(s): | Yu B, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Completion Date: | 06/2016 |
| Researcher : Yuen KS |
| Project Title: | 34th Annual Meeting of the American Society for Virology (ASV2015); Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells |
| Investigator(s): | Yuen KS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| Researcher : Zhou Z |
| Project Title: | Understanding the regulation of MT1-MMP activity in tumorigenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2006 |
| Project Title: | Screening anti-ageing substances in small chemical library using premature ageing animals |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2007 |
| Project Title: | Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2011 |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling |
| Investigator(s): | Zhou Z, Osorio Da Silva LA |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | MT1-MMP-mediated ADAM15 shedding in angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | Chromatin remodeling in laminopathy-based progeria |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2013 |
| Project Title: | Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2013 |
| Project Title: | Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2014 |
| Project Title: | Regulation of heterochromatin remodeling in DNA repair and aging |
| Investigator(s): | Zhou Z, Hao Q, Chu IK |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 02/2014 |
| Project Title: | Outstanding Researcher Award 2013-14 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2014 |
| Project Title: | Lamin A in Chromatin Dynamics and Aging |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2016 |
| Project Title: | SIRT6 in bone marrow stromal cell potency and the development of osteoporosis |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |