DEPT OF CLINICAL ONCOLOGY



Researcher : Au GKH
List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.


Researcher : CAO T
List of Research Outputs

TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.
Tang Z., CAO T., Lin S., Fu L., Li S., Guan X. and Cai Z., Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry., Talanta. 2016, 152: 119-126.


Researcher : CHEN J
List of Research Outputs

Li J., CHEN J., Zeng T.T., He F., Chen S.P., Ma S.K.Y., Bi J., Zhu X.F. and Guan X., CD133+ liver cancer stem cells resist interferon-gamma induced autophagy, BMC Cancer. 2016, 16: 15.
TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.
Yang J., Lv X., CHEN J., Xia W., JIANG C., Zeng T., Ye Y., Ke L., Yu Y., Liang H., Guan X., Guo X. and Xiang Y., CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP92/9 pathway., Oncotarget. 2016, 7(13): 15632-15647.


Researcher : CHOI SS.A
List of Research Outputs

Ko J.M.Y., NING L., CHOI S.S...A., LEI C., Wang L.D. and Lung M.L., Rare deleterious germline muations of candidate genes associated with risk of familial esophageal squamous cell carcinoma by targeted sequencing, 107th American Association for Cancer Research. 2016.


Researcher : Chan KC
List of Research Outputs

Chan K.C., Lung H.L., Kahn M., Lung M.L. and Mal N.K., ICG-001 Wnt modulator inhibits the self-renewal ability of EBV-positive NPC cells via regulation of key epigenetic regulator DNMT1, NPC Gordon Research Conference. 2016.


Researcher : Chan WLW
List of Research Outputs

Chan W.L.W., Lam K.O., Siu W.K.S. and Yuen K.K., Chemotherapy at end-of-life: an integration of oncology and palliative team, Supportive Care in Cancer. 2016, 24: 1421.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
Wong K.P., Lang H.H.B., Chan W.L.W., Lam K.O., Wan K.Y. and Lo C.Y., Treatment strategy in stage IVB anaplastic thyroid carcinoma, a single center experience (Poster Presentation), Surgery for Tomorrow's Asia, RCSEd/CSHK Conjoint Scientific Congress 2015 & Asian Surgical Association 20th Asian Congress of Surgery, Hong Kong, 11-13 September 2015.


Researcher : Cheung AKL
Project Title:Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Investigation of EBV-associated host cell histone modification and gene expression changes in nasopharyngeal carcinoma by next generation sequencing
Investigator(s):Cheung AKL, Lung ML, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:08/2013
Completion Date:08/2015


Project Title:Functional validation of a novel DUB3 somatic mutation in tumors of nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2015
Completion Date:06/2016


Project Title:Elucidation of the role of Epstein-Barr Virus in modulating DNA damage repair and cancer-associating signaling pathways via bivalent H3K4me3 and H3K27me3 histone modifications in nasopharyngeal epithelial and cancer cells
Investigator(s):Cheung AKL, Lung ML, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017
Completion Date:06/2016


List of Research Outputs

Cheung A.K.L., Dai W., LEONG M.L., Tsao G.S.W. and Lung M.L., EBV infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4m33 mark, 107th American Association for Cancer Research. 2016.
Cheung A.K.L., Kwok C.T.T. and Lung M.L., Functional investigation of tumor suppressor MIPOL1 in suppression of NPC tumorigenesis, NPC Gordon Research Conference. 2016.
Dai W., ZHENG H., Cheung A.K.L. and Lung M.L., Genetic and epigenetic landscape of nasopharyngeal carcinoma, Chinese Clinical Oncology. 2016, 5: 16-16.
Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Hui K.F., Cheung A.K.L., CHOI C.K., YEUNG P.L., Middeldorp J.M., Lung M.L., Tsao G.S.W. and Chiang A.K.S., Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir, Int J Cancer. 2015.
PHOON Y.P., Cheung A.K.L., Cheung F.M.F., Chan K.F., Wong S., Wong W.Y., Tung S.Y., Yau C.C., Ng W.T. and Lung M.L., IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling , International Journal of Cancer. 2016, 138: 160-170.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Choi CW
List of Research Outputs

Lam K.O., Lee W.M.A., Choi C.W., Sze C.K.H., Zietman A.L., Hopkins K.I. and Rosenblatt E., Global Pattern of Nasopharyngeal Cancer: Correlation of Outcome With Access to Radiation Therapy, International Journal of Radiation Oncology*Biology*Physics. 2016, 94: 1106-1112.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.


Researcher : Chow KKR
List of Research Outputs

Liu M., Chow K.K.R., Li Y. and Guan X., CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors, Hepatology. 2016, 63(5): 1544-1559.


Researcher : Choy TS
List of Research Outputs

Lau K.S., Lam K.O., Choy T.S., Shek T.W.H., Chung L.P. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer and predicted pattern of metastases, In: Annals of Oncology, European Society of Medical Oncology Asia 2015 Congress. 2015, 26(suppl 9): ix46.


Researcher : Chua DTT
Project Title:2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2000


Project Title:2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2003


Project Title:46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2004




Researcher : DENG M
List of Research Outputs

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Dai W
List of Research Outputs

Cheung A.K.L., Dai W., LEONG M.L., Tsao G.S.W. and Lung M.L., EBV infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4m33 mark, 107th American Association for Cancer Research. 2016.
Dai W., ZHENG H., Cheung A.K.L. and Lung M.L., Genetic and epigenetic landscape of nasopharyngeal carcinoma, Chinese Clinical Oncology. 2016, 5: 16-16.
Dai W., Methylation Biomarkers in Nasopharyngeal Carcinoma, NPC Gordon Research Conference. 2016.
Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Ng H.Y., Ko J.M.Y., Yu Z., Ip J.C.Y., Dai W., Cal S. and Lung M.L., DESC1, a novel tumor suppressor, sensitises cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma, International Journal of Cancer. 2016, 138: 2940-2951.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Fu L
List of Research Outputs

Lin S.H., Liu T., MING X., Tang Z., Fu L., Schmitt-Kopplin P., Kanawati B., Guan X. and Cai Z., Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions., Scientific Reports. 2016, 6: 21184.
Tang Z., CAO T., Lin S., Fu L., Li S., Guan X. and Cai Z., Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry., Talanta. 2016, 152: 119-126.


Researcher : Guan X
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2015
Completion Date:03/2016


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs

Chow L.W.C., Costa L., Teh B.T., Li D.Q., Feng G., Guan X., Nair A., Zhu L., Sugimoto M., Dutt A., Toi M., Gupta S., Badwe R., Knapp S., Pillai M.R. and Kumar R., Cancer genomics and biology 2015-Meeting report., Genes Cancer. 2016, 1-2: 1-6.
He L.R., Ma N.F., Chen J.W., Li B.K., Guan X., Liu M.Z. and Xie D., Overexpression Of Chd1l Is Positively Associated With Metastasis Of Lung Adenocarcinoma And Predicts Patients Poor Survival, Oncotarget. 2015, 6(31): 31181-31190.
Huang P.Y., Zeng T.T., Li M.Q., Ban X., Zhu Y.H., Zhang B.Z., Mai H.Q., Zhang L., Guan X. and Li Y., Proteomic Analysis Of A Nasopharyngeal Carcinoma Cell Line And A Nasopharyngeal Epithelial Cell Line, Tumori . 2015, 101(6): 676-683.
JIANG L., Kwong D.L.W., Li Y., Liu M., Yuan Y.F., Li Y., Fu L. and Guan X., HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma, Carcinogenesis. 2015, 36: 1111-1120.
Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255.
Li C.P., Cai M.Y., Jiang L.J., Mai S.J., Chen J.W., Wang F.W., Liao Y.J., Chen W.H., Jin X.H., Pei X.Q., Guan X., Zeng M.S. and Xie D., CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma., Carcinogenesis. 2016, 37(6): 557-566.
Li J., CHEN J., Zeng T.T., He F., Chen S.P., Ma S.K.Y., Bi J., Zhu X.F. and Guan X., CD133+ liver cancer stem cells resist interferon-gamma induced autophagy, BMC Cancer. 2016, 16: 15.
Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18.
Lin S.H., Liu T., MING X., Tang Z., Fu L., Schmitt-Kopplin P., Kanawati B., Guan X. and Cai Z., Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions., Scientific Reports. 2016, 6: 21184.
Liu M., Chow K.K.R., Li Y. and Guan X., CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors, Hepatology. 2016, 63(5): 1544-1559.
TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.
Tang Z., CAO T., Lin S., Fu L., Li S., Guan X. and Cai Z., Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry., Talanta. 2016, 152: 119-126.
To K.Y., Mak A.S.C., Fung E.Y.M., Che C.M., Guan X. and Wong A.S.T., An isogenic experimental model identifies b-catenin as a molecular target in ovarian cancer metastasis, AACR Annual Meeting 2016, New Orleans, LA. 2016.
Xu L., Li X., Cai M., Chen J., Li X., Wu W.K., Kang W., Tong J., To K.F., Guan X., Sung J.J., Chan F.K. and Yu J., Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer., Gut. 2016, 65(4): 635-646.
Yang H., Li X.D., Zhou Y., Ban X., Zeng T.T., Zhang B.Z., Yun J., Xie D., Guan X. and Li Y., Stemness And Chemotherapeutic Drug Resistance Induced By Eif5a2 Overexpression In Esophageal Squamous Cell Carcinoma, Oncotarget. 2015, 6(28): 26079-26089.
Yang J., Lv X., CHEN J., Xia W., JIANG C., Zeng T., Ye Y., Ke L., Yu Y., Liang H., Guan X., Guo X. and Xiang Y., CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP92/9 pathway., Oncotarget. 2016, 7(13): 15632-15647.
Zhang L., Guan X. and Lee V.H.F., PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma, In: Curtis C Harris , Carcinogenesis. 2016.
Zhu Y.H., Zhang B., Li M., Huang P., Sun J., Fu J. and Guan X., Prognostic Significance Of Fam3c In Esophageal Squamous Cell Carcinoma, Diagnostic Pathology. 2015, 10(1): 192.


Researcher : Guan X.
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2015
Completion Date:03/2016


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs



Researcher : Guan XY
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2015
Completion Date:03/2016


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs



Researcher : Ho PYP
List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
So T.H., Ho P.Y.P., Leung T.W. and Kwong D.L.W., Pneumocystis Jiroveci Infection and Craniospinal Irradiation with Arc Therapy: a Report of Two cases, In: WCW Chu, RKC Ngan, MK yuen, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2016, 19: 126-131.


Researcher : JIANG C
List of Research Outputs

Yang J., Lv X., CHEN J., Xia W., JIANG C., Zeng T., Ye Y., Ke L., Yu Y., Liang H., Guan X., Guo X. and Xiang Y., CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP92/9 pathway., Oncotarget. 2016, 7(13): 15632-15647.


Researcher : JIANG L
List of Research Outputs

JIANG L., Kwong D.L.W., Li Y., Liu M., Yuan Y.F., Li Y., Fu L. and Guan X., HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma, Carcinogenesis. 2015, 36: 1111-1120.


Researcher : KAN PQR
List of Research Outputs

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Ko JMY
Project Title:Study of alternative splicing of esophageal squamous cell carcinoma through transcriptome analysis in Hong Kong
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014
Completion Date:12/2015


Project Title:The clinical relevance of telomere attrition and NPC genetic susceptibility
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2015


Project Title:Validation and functional characterization of candidate genetic susceptibility loci and the inherited risk for familial esophageal squamous cell carcinoma (ESCC)
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:10/2015


Project Title:AACR Annual Meeting 2016 in New Orleans, Louisiana; Rare deleterious germline mutations of candidate genes associated with risk of familial esophageal squamous cell carcinoma (ESCC) by targeted sequencing
Investigator(s):Ko JMY
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2016
Completion Date:04/2016


List of Research Outputs

Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Ko J.M.Y., NING L., CHOI S.S...A., LEI C., Wang L.D. and Lung M.L., Rare deleterious germline muations of candidate genes associated with risk of familial esophageal squamous cell carcinoma by targeted sequencing, 107th American Association for Cancer Research. 2016.
Ko J.M.Y. and Lung M.L., Telomere length in peripheral blood leukocytes and NPC risk in Hong Kong Chinese, NPC Gordon Research Conference. 2016.
Ng H.Y., Ko J.M.Y., Yu Z., Ip J.C.Y., Dai W., Cal S. and Lung M.L., DESC1, a novel tumor suppressor, sensitises cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma, International Journal of Cancer. 2016, 138: 2940-2951.
Yu Z., Ko J.M.Y., Law S.Y.K., Wang L.D. and Lung M.L., Differential expression and functional impact of the alternatively spliced transcripts of ECM1 in esophageal squamous cell carcinoma, 107th American Association for Cancer Research. 2016.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Kwok CTT
List of Research Outputs

Cheung A.K.L., Kwok C.T.T. and Lung M.L., Functional investigation of tumor suppressor MIPOL1 in suppression of NPC tumorigenesis, NPC Gordon Research Conference. 2016.


Researcher : Kwong DLW
Project Title:PET/CT scan for early response monitoring and radiation dose escalation in locally advanced nasopharyngeal carcinoma
Investigator(s):Kwong DLW, Khong PL, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012
Completion Date:11/2015


List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
JIANG L., Kwong D.L.W., Li Y., Liu M., Yuan Y.F., Li Y., Fu L. and Guan X., HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma, Carcinogenesis. 2015, 36: 1111-1120.
Kwong D.L.W., Continuous Nursing Education Programme, Tung Wah Hospital, Hong Kong, Radiotherapy and Chemotherapy for Head and Neck Cancers. 2016.
Lee V.H.F., Lo A.W., Leung C.Y., Shek W.H., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H. and Leung T.W., Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma, PLOS ONE. 2016, 11: e0157969.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Leung D.E.N.N.I.S. .K.C., Choy T.I.M. .S.H.I.N.G., Lam K.O., Lam P.U.I. .M.E.I., Leung T.O. .W.A.I. and Kwong D.L.W., Efficacy and safety of afatinib in Chinese patients with EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) previously responsive to first-generation tyrosine-kinase inhibitors (TKI) and chemotherapy: comparison with historical cohort using erlotinib, BMC Cancer. 2016, 16.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.
Li J.Y., Zheng L., Ma L., Kwong D.L.W., Cheung L.K. and Pow E.H.N., Effect of fluoride-modified titanium surface on early adhesion of irradiated osteoblasts, BioMed Research International. 2015, 1-9.
Pow E.H.N., Chen Z., Kwong D.L.W. and Lam O.L.T., Salivary Anionic Changes after Radiotherapy for Nasopharyngeal Carcinoma: A 1-Year Prospective Study, PLOS ONE. 2016, 11: e0152817.
So T.H., Ho P.Y.P., Leung T.W. and Kwong D.L.W., Pneumocystis Jiroveci Infection and Craniospinal Irradiation with Arc Therapy: a Report of Two cases, In: WCW Chu, RKC Ngan, MK yuen, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2016, 19: 126-131.
Tew I., Kwong D.L.W. and Pow E.H.N., Long-term quality of life after treatment of nasopharyngeal carcinoma, J Dent Res. 2016, 95(Spec Iss B): 357.
Wong W.K., Leung L.H. and Kwong D.L.W., Evaluation and optimization of the parameters used in multiple-atlas-based segmentation of prostate cancers in radiation therapy, The British Journal of Radiology. 2016, 89: 20140732.
Yuan C., Yip S.P., Wu V.W.C., Kwong D.L.W., Cheuk I.W. and Ying M., Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma, Radiation Oncology. 2015, 10: 39.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : LEI C
List of Research Outputs

Ko J.M.Y., NING L., CHOI S.S...A., LEI C., Wang L.D. and Lung M.L., Rare deleterious germline muations of candidate genes associated with risk of familial esophageal squamous cell carcinoma by targeted sequencing, 107th American Association for Cancer Research. 2016.


Researcher : LEONG ML
List of Research Outputs

Cheung A.K.L., Dai W., LEONG M.L., Tsao G.S.W. and Lung M.L., EBV infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4m33 mark, 107th American Association for Cancer Research. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Lam KO
Project Title:PD-L1 immunohistochemical expression in esophageal cancers
Investigator(s):Lam KO, Kwong DLW, Lee VHF, Law SYK
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2015
Completion Date:09/2016


Project Title:Improving Access to Chemotherapy in Locorgionally Advanced Esophageal and Rectal Cancer for the Poor and Sick
Investigator(s):Lam KO, Lee VHF, So TH, Sze CKH, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2016


List of Research Outputs

Chan W.L.W., Lam K.O., Siu W.K.S. and Yuen K.K., Chemotherapy at end-of-life: an integration of oncology and palliative team, Supportive Care in Cancer. 2016, 24: 1421.
Cheng H.W., Lam K.O., Li C.W., Chan K.Y. and Sham M.M., Successful Analgesic use of Ketamine infusion in malignant cord compression, Pain Medicine. 2015.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Lam K.O., Aflibercept in a patient with metastatic colorectal cancer previously treated with bevacizumab, The JOC Bulletin. 2016.
Lam K.O., Ant-EGFR rechallenge: A late -line treatment option for RAS wild-type mCRC, Oncology Tribune. 2016.
Lam K.O. and Law S.Y.K., Asia and Latin America Virtual Centers of Excellence: Advanced Gastric Cancer Tumor Board, Eli Lilly and Company. 2015.
Lam K.O., Beyond 2nd Line Treatment in Metastatic Colorectal Cancer -Evidence and Perspectives, 未期結直腸癌二線後之治療 - 証據與展望, The 11th Pan-Pearl-River Area Conference of Radiation Oncology & Prof. Ho Hung Chiu Memorial Symposium on Nasopharyngeal Cancer, HK and Shenzhen, China. 2016.
Lam K.O., Current Standard of Care for Advanced Gastric Cancer in Hong Kong, Gastric Cancer Master Class, 42th Annual Meeting of Korean Cancer Association with International Cancer Conference, Seoul, Korea. 2016.
Lam K.O., Editorial Board, JBR Journal of Translational Clinical and Experimental Oncology. 2015.
Lam K.O., Fluoropyrimidines in metastatic gastric cancer: much of a muchness?, The 6th Joint Scientific Meeting of RCR and HKCR. 2015.
Lam K.O., Lee W.M.A., Choi C.W., Sze C.K.H., Zietman A.L., Hopkins K.I. and Rosenblatt E., Global Pattern of Nasopharyngeal Cancer: Correlation of Outcome With Access to Radiation Therapy, International Journal of Radiation Oncology*Biology*Physics. 2016, 94: 1106-1112.
Lam K.O., Oncologic Management of Upper Gastro-intestinal Cancers, Post-Registration Certificate Course in Oncology Nursing, HK. 2016.
Lam K.O., Optimizing Third-Line Therapy for Metastatic CRC, Continuous Medical Education, Pusat Perubatan UM, Kuala Lumpur, Malaysia. 2016.
Lam K.O., Optimizing Third-Line Therapy for metastatic CRC, Round Table Expert Exchange, Stivarga Speaker Tour, Kuala Lumpur, Malaysia. 2016.
Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.
Lam K.O., S1 in Metastatic Gastric Cancer-Another "Me-Too" Fluoropyrimidine?, Taiho Asian KOLs Meeting. 2015.
Lam K.O., Lee W.M.A., Ng W.T. and Kirsten I.H., The International Atomic Energy Agency global initiatives on nasopharyngeal cancer treatment, Chinese Clinical Oncology. 2016, 5: 27-27.
Lam K.O., Chu S., Ho S.K.D., Ip W.C.T., Chan O.L., Lee F.K., Chan W.H., Lee W.Y., Sin K.M., Flynn B.T. and Ho W.K.H., Treatment regret amongst survivors of nasopharyngeal cancer (NPC) treated with radical radiotherapy, 24th Annual Scientific Meeting of The Hong Kong College of Radiologists. 2015.
Lau K.S., Lam K.O., Choy T.S., Shek T.W.H., Chung L.P. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer and predicted pattern of metastases, In: Annals of Oncology, European Society of Medical Oncology Asia 2015 Congress. 2015, 26(suppl 9): ix46.
Lee V.H.F., Lo A.W., Leung C.Y., Shek W.H., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H. and Leung T.W., Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma, PLOS ONE. 2016, 11: e0157969.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Leung D.E.N.N.I.S. .K.C., Choy T.I.M. .S.H.I.N.G., Lam K.O., Lam P.U.I. .M.E.I., Leung T.O. .W.A.I. and Kwong D.L.W., Efficacy and safety of afatinib in Chinese patients with EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) previously responsive to first-generation tyrosine-kinase inhibitors (TKI) and chemotherapy: comparison with historical cohort using erlotinib, BMC Cancer. 2016, 16.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Lam TC
List of Research Outputs

Lam T.C., Stereotactic Body Radiotherapy for the Management of Spinal Metastasis, Multi-specialty Medical Mega Conference 2016. 2016.
Lam T.C., Stereotactic Spinal Radiation Therapy – Team Work Approach in HA Settings, Hospital Authority Convention 2016. 2016.


Researcher : Le QX
List of Research Outputs

Lee W.M.A., Ng W.T., Le Q.X., Chan A.T.C., Chan J.Y.W. and Sze C.K.H., Nasopharynx, In: Brian O'Sullivan, James D. Brierley, Anil K. D'Cruz, Martin F. Fey, Raphael Pollock, Jan B. Vermorken, Shao Hui Huang, UICC Manual of Clinical Oncology: O'Sullivan/UICC. Oxford, John Wiley & Sons, Ltd., 2015, 512-523.


Researcher : Lee AWM
Project Title:Prognostic and predictive biomarkers in loco-regionally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemotherapy: pooled analysis of data from the NPC-9901 and NPC-9902 trials
Investigator(s):Lee WMA, Lam KO, Lee VHF, So TH, Kwong DLW, Guan X, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2016


List of Research Outputs



Researcher : Lee VHF
Project Title:Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2012


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Granulocyte-colony stimulating factor (G-CSF) support to prevent neutropenia and its complications for patients receiving palliative chemotherapy for their stage IV metastatic cancer
Investigator(s):Lee VHF, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Development of Cancer Registry of Human Papilloma Virus (HPV)-associated Oral and Oropharyngeal Cancers in Hong Kong and its Correlation with Survival Outcomes
Investigator(s):Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:ASTRO 56th Annual Meeting; Comparison of Post-treatment Plasma EBV DNA with Nasopharyngeal Biopsy in Patients After Radical (Chemo)Radiotherapy for Non-metastatic Nasopharyngeal Cancer
Investigator(s):Lee VHF
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2014


Project Title:Magnetic resonance imaging (MRI) for monitoring treatment response in patients with inoperable hepatocellular carcinoma treated with transarterial chemoembolization (TACE) and/or radiotherapy
Investigator(s):Lee VHF, Kwong DLW, Wong CS
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2015


Project Title:FDG and 11C-acetate PET-CT scan to assess tumour response after stereotactic body radiation therapy as bridging therapy for patients with hepatocellular carcinoma awaiting liver transplantation
Investigator(s):Lee VHF, Wong CLT, Vardhanabhuti V, Lam KO, Leung TW, Khong PL, Chan SC, Lo CM
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016


Project Title:Role of individual dietary counselling on weight loss and change in quality of life in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy
Investigator(s):Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016


Project Title:Efficient Algorithms and Hardware Accelerators for Tensor Decomposition and Their Applications to Multidimensional Data Analysis
Investigator(s):Lee VHF
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2016


List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.
Lee V.H.F., Lo A.W., Leung C.Y., Shek W.H., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H. and Leung T.W., Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma, PLOS ONE. 2016, 11: e0157969.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Leung D.E.N.N.I.S. .K.C., Choy T.I.M. .S.H.I.N.G., Lam K.O., Lam P.U.I. .M.E.I., Leung T.O. .W.A.I. and Kwong D.L.W., Efficacy and safety of afatinib in Chinese patients with EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) previously responsive to first-generation tyrosine-kinase inhibitors (TKI) and chemotherapy: comparison with historical cohort using erlotinib, BMC Cancer. 2016, 16.
Lee V.H.F., Wang J.J., Xu J., Sihoe D.L.A. and Wong M.P., Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia, International Journal of Cancer. 2015, 137: 311-319.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.
Ma L., Wang D.D., Huang Y., Yan H., Wong M.P. and Lee V.H.F., EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib, BMC Bioinformatics. 2015, 16.
Wang D.D., Lee V.H.F., Zhu G.Y., Zou B., Ma L.C. and Yan H., Selectivity profile of afatinib for EGFR-mutated non-small-cell lung cancer, Mol. BioSyst.. 2016, 12: 1552-1563.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.
ZHANG N., Fielding R., Soong I., Chan K.K.L., Tsang W.H.J., Lee V.H.F., Lee C., Ng A., Sez W.K., Tin S.P.P. and Lam W.W.T., Illness perceptions among cancer survivors, Supportive Care in Cancer. Springer, 2016, 24(3): 1295-1304.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.
Zhang L., Guan X. and Lee V.H.F., PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma, In: Curtis C Harris , Carcinogenesis. 2016.


Researcher : Lee WMA
Project Title:Prognostic and predictive biomarkers in loco-regionally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemotherapy: pooled analysis of data from the NPC-9901 and NPC-9902 trials
Investigator(s):Lee WMA, Lam KO, Lee VHF, So TH, Kwong DLW, Guan X, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2016


List of Research Outputs

Brouwer C.L., Steenbakkers R.J.H.M., Bourhis J., Budach W., Grau C., Gregoire V., van Herk M., Lee W.M.A., Maingon P., Nutting C., O'Sullivan B., Porceddu S.V., Rosenthal D.I., Sijtsema N.M. and Langendijk J.A., CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines, Radiotherapy and Oncology. 2015, 117: 83-90.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Lam K.O., Lee W.M.A., Choi C.W., Sze C.K.H., Zietman A.L., Hopkins K.I. and Rosenblatt E., Global Pattern of Nasopharyngeal Cancer: Correlation of Outcome With Access to Radiation Therapy, International Journal of Radiation Oncology*Biology*Physics. 2016, 94: 1106-1112.
Lam K.O., Lee W.M.A., Ng W.T. and Kirsten I.H., The International Atomic Energy Agency global initiatives on nasopharyngeal cancer treatment, Chinese Clinical Oncology. 2016, 5: 27-27.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee W.M.A., Clinical Trials of Head & Neck Cancer in Hong Kong – Past Achivements and Future Prospects, The Hong Kong Head & Neck Society. 2015.
Lee W.M.A., Contribution by Hong Kong to the Battle against Nasopharyngeal Cancer, The 11th Pan-Pearl- River Area Conference of Radiation Oncology cum Prof. Ho Hung Chiu Memorial Symposium on Nasopharyngeal Cancer, Shenzhen and Hong Kong, China. 2016.
Lee W.M.A., Ma B.B.Y., Ng W.T. and Chan A.T.C., Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective, Journal of Clinical Oncology. 2015, 33: 3356-3364.
Lee W.M.A., Ng W.T., Le Q.X., Chan A.T.C., Chan J.Y.W. and Sze C.K.H., Nasopharynx, In: Brian O'Sullivan, James D. Brierley, Anil K. D'Cruz, Martin F. Fey, Raphael Pollock, Jan B. Vermorken, Shao Hui Huang, UICC Manual of Clinical Oncology: O'Sullivan/UICC. Oxford, John Wiley & Sons, Ltd., 2015, 512-523.
Lee W.M.A., Staging of Nasopharyngeal Carcinoma – Global Perspective, Chinese Society of Radiation Oncology, Chengdu, China. 2015.
Ng W.T., Chang A.T.Y., Lee S.W.M., Sze C.K.H. and Lee W.M.A., Chemotherapy for Nasopharyngeal Cancer: Neoadjuvant, Concomitant, and/or Adjuvant., Curr Treat Options Oncol.. 2015, 16.
Pang J.J., Zhong J.F., Chan L.L.K., O'Sullivan B., Lin S.J., Chen Y.B., Guo Q.J., Kan W.K., Xiao Y.P., W X., Le Q.T., Glastonbury C.M., Colevas A.D., Weber R.S., Shah J.P. and Lee W.M.A., Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy, Cancer. 2016, 122: 546-558.
Strojan P., Vermorken J.B., Beitler J.J., Saba N.F., Haigentz M., Bossi P., Worden F.P., Langendijk J.A., Eisbruch A., Mendenhall W.M., Lee W.M.A., Harrison L.B., Bradford C.R., Smee R., Silver C.E., Rinaldo A., Ferlito A. and Eisele D.W., Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: A systematic review, Head & Neck. 2016, 38: E2151-E2158.
Sze C.K.H., Blanchard P., Ng W.T., Pignon J.P. and Lee W.M.A., Chemotherapy for Nasopharyngeal Carcinoma – Current Recommendation and Controversies, Hematology/Oncology Clinics of North America. 2015, 29: 1107-1122.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Leung TW
List of Research Outputs

Lau K.S., Lam K.O., Choy T.S., Shek T.W.H., Chung L.P. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer and predicted pattern of metastases, In: Annals of Oncology, European Society of Medical Oncology Asia 2015 Congress. 2015, 26(suppl 9): ix46.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.
So T.H., Ho P.Y.P., Leung T.W. and Kwong D.L.W., Pneumocystis Jiroveci Infection and Craniospinal Irradiation with Arc Therapy: a Report of Two cases, In: WCW Chu, RKC Ngan, MK yuen, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2016, 19: 126-131.


Researcher : Li Y
Project Title:Lorne Cancer Conference 2016; Identification and characterization of a putative tumor suppressor gene AKR7A3 in hepatocellular carcinoma
Investigator(s):Li Y
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2016
Completion Date:02/2016


List of Research Outputs

JIANG L., Kwong D.L.W., Li Y., Liu M., Yuan Y.F., Li Y., Fu L. and Guan X., HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma, Carcinogenesis. 2015, 36: 1111-1120.
Liu M., Chow K.K.R., Li Y. and Guan X., CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors, Hepatology. 2016, 63(5): 1544-1559.


Researcher : Liu M
Project Title:Investigation of CHD1L downstream targets and their roles in regulating hepatocellular carcinoma differentiation.
Investigator(s):Liu M, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2015
Completion Date:06/2016


List of Research Outputs

JIANG L., Kwong D.L.W., Li Y., Liu M., Yuan Y.F., Li Y., Fu L. and Guan X., HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma, Carcinogenesis. 2015, 36: 1111-1120.
Liu M., Chow K.K.R., Li Y. and Guan X., CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors, Hepatology. 2016, 63(5): 1544-1559.


Researcher : Luk MY
List of Research Outputs

Ho R.T.H., Lo H.Y.P. and Luk M.Y., A Good Time to Dance? A Mixed-Methods Approach of the Effects of Dance Movement Therapy for Breast Cancer Patients During and After Radiotherapy, Cancer Nursing. 2016, 39(1): 32-41.
Ho R.T.H., Fong T.C.T., Cheung K.M., Yip P.S.F. and Luk M.Y., Effects of a Short-Term Dance Movement Therapy Program on Symptoms and Stress in Patients With Breast Cancer Undergoing Radiotherapy: A Randomized, Controlled, Single-Blind Trial, Journal of Pain and Symptom Management. 2016, 51(5): 824-831.
Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.


Researcher : Lung HL
Project Title:The serum amyloid A1 (SAA1) Polymorphisms as Risk Factors in Esophageal Squamous Cell Carcinoma
Investigator(s):Lung HL, Lung ML, Law SYK
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:Establishment of human nasopharyngeal carcinoma in 3D invasion and angiogenesis organotypic culture to study hypoxia-induced tumor invasion and angiogenesis
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2014
Completion Date:07/2015


Project Title:The functional role(s) of SAA1 polymorphisms in integrin-focal adhesion kinase-mediated cell adhesion and tumor metastasis
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2014
Completion Date:07/2015


Project Title:The effects of the IKKbeta-specific inhibitor PS1145 on tumor formation and metastasis in nasopharyngeal carcinoma
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2015


List of Research Outputs

Chan K.C., Lung H.L., Kahn M., Lung M.L. and Mal N.K., ICG-001 Wnt modulator inhibits the self-renewal ability of EBV-positive NPC cells via regulation of key epigenetic regulator DNMT1, NPC Gordon Research Conference. 2016.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.
ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015.


Researcher : Lung ML
Project Title:Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2009


Project Title:Centre for Nasopharyngeal Carcinoma Research
Investigator(s):Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:Clinical Oncology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2010


Project Title:Elucidating the genetic basis for early-age onset nasopharyngeal carcinoma in Hong Kong
Investigator(s):Lung ML, Sham PC, Yang W, Cherny SS, Chiang AKS
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013
Completion Date:03/2016


Project Title:Elucidating the functional role of a metastasis-associated extracellular matrix gene, ECM1, in esophageal cancer
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


Project Title:Advances in Nasopharyngeal Carcinoma Studies
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Croucher Advanced Study Institute
Start Date:11/2014


Project Title:Secretory NID2, a basement membrane protein facilitating cell adhesion, migration, and metastasis in human cancers
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2015


Project Title:Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2015


Project Title:Regulation and Clinical Implication of PD-L1 Expression in Esophageal Tumor Cells subjected to Chemotherapy
Investigator(s):Lung ML, Ko JMY, Yu Z
Department:Clinical Oncology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:11/2015


Project Title:American Association for Cancer Research Annual Meeting 2016; Epstein-Barr virus infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4me3 mark
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2016
Completion Date:04/2016


Project Title:Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma
Investigator(s):Lung ML, Chan KW, Law SYK, Song Y
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2016


List of Research Outputs

Chan K.C., Lung H.L., Kahn M., Lung M.L. and Mal N.K., ICG-001 Wnt modulator inhibits the self-renewal ability of EBV-positive NPC cells via regulation of key epigenetic regulator DNMT1, NPC Gordon Research Conference. 2016.
Cheung A.K.L., Dai W., LEONG M.L., Tsao G.S.W. and Lung M.L., EBV infection suppresses the DNA repair mechanisms in nasopharyngeal epithelial cells via reduction of the H3K4m33 mark, 107th American Association for Cancer Research. 2016.
Cheung A.K.L., Kwok C.T.T. and Lung M.L., Functional investigation of tumor suppressor MIPOL1 in suppression of NPC tumorigenesis, NPC Gordon Research Conference. 2016.
Dai W., ZHENG H., Cheung A.K.L. and Lung M.L., Genetic and epigenetic landscape of nasopharyngeal carcinoma, Chinese Clinical Oncology. 2016, 5: 16-16.
Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Hui K.F., Cheung A.K.L., CHOI C.K., YEUNG P.L., Middeldorp J.M., Lung M.L., Tsao G.S.W. and Chiang A.K.S., Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir, Int J Cancer. 2015.
Ko J.M.Y., NING L., CHOI S.S...A., LEI C., Wang L.D. and Lung M.L., Rare deleterious germline muations of candidate genes associated with risk of familial esophageal squamous cell carcinoma by targeted sequencing, 107th American Association for Cancer Research. 2016.
Ko J.M.Y. and Lung M.L., Telomere length in peripheral blood leukocytes and NPC risk in Hong Kong Chinese, NPC Gordon Research Conference. 2016.
Lung M.L., Corporate Sponsor: Lee’s Pharmaceutical (HK) Ltd. 2015-2017 - “Regulation and clinical implication of PD-L1 expression in esophageal tumor cells subjected to chemotherapy” HK$2,598,540, Innovation and Technology Commission. 2015.
Lung M.L., GRF Research Grant (Competitive Earmarked Research Grant) 2015-2018 - “Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma” HK$971,461 (Transferred from PI to Co-I, due to departure of PI), Research Grants Council. 2015.
Lung M.L., GRF Research Grant 2015-2017 - “Functional and mechanistic investigation of frequent p53 gain-of-function mutations in esophageal squamous cell carcinoma” HK$1,168,311, Research Grants Council. 2015.
Lung M.L., Landscape of NPC somatic mutations, Karolinska Institute, Stockholm, Sweden invited seminar. 2015.
Lung M.L., Microcell-mediated chromosome transfer, Encyclopedia of Cancer. Springer, 2015.
Lung M.L., Research Grant 2016-2019 - “Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma” HK$7,570,304, RGC Collaborative Research Fund. 2016.
Lung M.L., Whole-exome sequencing approaches to identify somatic mutations in NPC, Department of Chemical Pathology, Chinese University of Hong Kong seminar. 2016.
MAI Z., Lo C.M.M., Xu J., Chan K.P., Wong C.M., Lung M.L. and Lam T.H., Milk consumption in relation to incidence of nasopharyngeal carcinoma in 48 countries/regions, BMC Cancer. 2015, 15(1): 994.
Ng H.Y., Ko J.M.Y., Yu Z., Ip J.C.Y., Dai W., Cal S. and Lung M.L., DESC1, a novel tumor suppressor, sensitises cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma, International Journal of Cancer. 2016, 138: 2940-2951.
PHOON Y.P., Cheung A.K.L., Cheung F.M.F., Chan K.F., Wong S., Wong W.Y., Tung S.Y., Yau C.C., Ng W.T. and Lung M.L., IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling , International Journal of Cancer. 2016, 138: 160-170.
Yip T.T.C., Kwok H.Y.Y., Wong B.M.Y., You S.S.Y., Fong A.H.W., Cheng W.W., Lai C., Shek C.C., Leung K.H., Chiang A.K.S., Hui K.F., Ma V.V.S., Lung M.L. and Ngan R.K.C., Development of locked nucleic acid PCR technique for detecting circulating EBV DNA with dramatic enhancement in sensitivity in NPC patients, NPC Gordon Research Conference. 2016.
Yu Z., Ko J.M.Y., Law S.Y.K., Wang L.D. and Lung M.L., Differential expression and functional impact of the alternatively spliced transcripts of ECM1 in esophageal squamous cell carcinoma, 107th American Association for Cancer Research. 2016.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.
ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015.


Researcher : MING X
List of Research Outputs

Lin S.H., Liu T., MING X., Tang Z., Fu L., Schmitt-Kopplin P., Kanawati B., Guan X. and Cai Z., Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions., Scientific Reports. 2016, 6: 21184.


Researcher : Ma SKY
Project Title:Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):Ma SKY, Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013
Completion Date:10/2016


Project Title:Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):Ma SKY, Chan KW
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


Project Title:Outstanding Young Researcher Award 2012-13
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:01/2014


Project Title:A multidisciplinary study on hepatic cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Croucher Innovation Awards
Start Date:04/2014


Project Title:miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014
Completion Date:08/2015


Project Title:Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Early Career Scheme (ECS)
Start Date:01/2015


Project Title:PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2015


Project Title:A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):Ma SKY, Guan X, Lo CM, Man K
Department:Anatomy
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2015


Project Title:PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF
Investigator(s):Ma SKY
Department:School of Biomedical Sciences
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2016


Project Title:Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer
Investigator(s):Ma SKY
Department:School of Biomedical Sciences
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:05/2016




Researcher : NING L
List of Research Outputs

Ko J.M.Y., NING L., CHOI S.S...A., LEI C., Wang L.D. and Lung M.L., Rare deleterious germline muations of candidate genes associated with risk of familial esophageal squamous cell carcinoma by targeted sequencing, 107th American Association for Cancer Research. 2016.


Researcher : Ng CY
List of Research Outputs

Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.


Researcher : Ng HY
List of Research Outputs

Ng H.Y., Ko J.M.Y., Yu Z., Ip J.C.Y., Dai W., Cal S. and Lung M.L., DESC1, a novel tumor suppressor, sensitises cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma, International Journal of Cancer. 2016, 138: 2940-2951.


Researcher : Ng WT
List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
Lam K.O., Lee W.M.A., Ng W.T. and Kirsten I.H., The International Atomic Energy Agency global initiatives on nasopharyngeal cancer treatment, Chinese Clinical Oncology. 2016, 5: 27-27.
Lee W.M.A., Ma B.B.Y., Ng W.T. and Chan A.T.C., Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective, Journal of Clinical Oncology. 2015, 33: 3356-3364.
Lee W.M.A., Ng W.T., Le Q.X., Chan A.T.C., Chan J.Y.W. and Sze C.K.H., Nasopharynx, In: Brian O'Sullivan, James D. Brierley, Anil K. D'Cruz, Martin F. Fey, Raphael Pollock, Jan B. Vermorken, Shao Hui Huang, UICC Manual of Clinical Oncology: O'Sullivan/UICC. Oxford, John Wiley & Sons, Ltd., 2015, 512-523.
Ng W.T., Chang A.T.Y., Lee S.W.M., Sze C.K.H. and Lee W.M.A., Chemotherapy for Nasopharyngeal Cancer: Neoadjuvant, Concomitant, and/or Adjuvant., Curr Treat Options Oncol.. 2015, 16.
Sze C.K.H., Blanchard P., Ng W.T., Pignon J.P. and Lee W.M.A., Chemotherapy for Nasopharyngeal Carcinoma – Current Recommendation and Controversies, Hematology/Oncology Clinics of North America. 2015, 29: 1107-1122.


Researcher : Ngan KC
List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.


Researcher : PHOON YP
List of Research Outputs

PHOON Y.P., Cheung A.K.L., Cheung F.M.F., Chan K.F., Wong S., Wong W.Y., Tung S.Y., Yau C.C., Ng W.T. and Lung M.L., IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling , International Journal of Cancer. 2016, 138: 160-170.


Researcher : SHUEN WH
List of Research Outputs

Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.


Researcher : Siu WKS
List of Research Outputs

Chan W.L.W., Lam K.O., Siu W.K.S. and Yuen K.K., Chemotherapy at end-of-life: an integration of oncology and palliative team, Supportive Care in Cancer. 2016, 24: 1421.


Researcher : So TH
Project Title:A Randomised Controlled Trial of Acupuncture for Oxaliplatin-based Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Colorectal Cancer Patients
Investigator(s):So TH, Lao L, Kwong DLW, Lee VHF, Lam KO, Sze CKH, Tsang WHJ
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2015


List of Research Outputs

So T.H., Frank Doyle Medal, In: /, Royal College of Radiologist in United Kingdom. 2016.
So T.H., Ho P.Y.P., Leung T.W. and Kwong D.L.W., Pneumocystis Jiroveci Infection and Craniospinal Irradiation with Arc Therapy: a Report of Two cases, In: WCW Chu, RKC Ngan, MK yuen, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2016, 19: 126-131.


Researcher : Soong SI
List of Research Outputs

Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang W.H.J., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2016, 25(1): 58-65.


Researcher : Sze CKH
List of Research Outputs

Lam K.O., Lee W.M.A., Choi C.W., Sze C.K.H., Zietman A.L., Hopkins K.I. and Rosenblatt E., Global Pattern of Nasopharyngeal Cancer: Correlation of Outcome With Access to Radiation Therapy, International Journal of Radiation Oncology*Biology*Physics. 2016, 94: 1106-1112.
Lam K.O., Lee K.C., Lee V.H.F., Sze C.K.H., Chiu W.Y.J., Leung R.C.Y. and Yau T.C.C., Regorafenib for metastatic colorectal cancer in community setting: a multicenter retrospective analysis in Hong Kong, In: Annals of Oncology, ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2015, 26 (suppl 4): iv79.
Lee V.H.F., Lo A.W., Leung C.Y., Shek W.H., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H. and Leung T.W., Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma, PLOS ONE. 2016, 11: e0157969.
Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lam K.O., Sze C.K.H., Ho P.Y.P., Chan W.L.W., Wong L.S. and Leung D., Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma, Clinical Oncology. 2016, 28: 42-49.
Lee W.M.A., Ng W.T., Le Q.X., Chan A.T.C., Chan J.Y.W. and Sze C.K.H., Nasopharynx, In: Brian O'Sullivan, James D. Brierley, Anil K. D'Cruz, Martin F. Fey, Raphael Pollock, Jan B. Vermorken, Shao Hui Huang, UICC Manual of Clinical Oncology: O'Sullivan/UICC. Oxford, John Wiley & Sons, Ltd., 2015, 512-523.
Ng W.T., Chang A.T.Y., Lee S.W.M., Sze C.K.H. and Lee W.M.A., Chemotherapy for Nasopharyngeal Cancer: Neoadjuvant, Concomitant, and/or Adjuvant., Curr Treat Options Oncol.. 2015, 16.
Sze C.K.H., Blanchard P., Ng W.T., Pignon J.P. and Lee W.M.A., Chemotherapy for Nasopharyngeal Carcinoma – Current Recommendation and Controversies, Hematology/Oncology Clinics of North America. 2015, 29: 1107-1122.


Researcher : Tiu TMRJ
List of Research Outputs

Hung F.N.I., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Chui A.H.W., Seto W.K.W., Fung J.Y.Y., Chan A.C.Y., Yuen J.C.H., Tiu T.M.R.J., CHOI M.Y.O., Lai C.L. and Yuen R.M.F., Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma, PLOS ONE. 2016, 11(2): e0148493.


Researcher : Tong CC
List of Research Outputs

Lee V.H.F., Chan S.Y., Choi C.W., Kwong D.L.W., Lam K.O., Tong C.C., Sze C.K.H., Leung T.W., Ng S. and Lee W.M.A., Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma, The Royal College of Radiologists. 2016.
Lee V.H.F., Leung D.K.C., Luk M.Y., Tong C.C., Law M.W., Ng C.Y., Wong K.K., Poon R.T.P., Kwong D.L.W. and Leung T.W., Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma, OncoTargets and Therapy. 2015, 8: 3457-3464.


Researcher : Tsang JWH
Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:10/2008


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang WHJ, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):Tsang WHJ, Khoo US
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


Project Title:Personalized Medicine for Elderly Breast Cancer Patients (CRF)
Investigator(s):Tsang WHJ
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:01/2015
Completion Date:02/2016


List of Research Outputs

Karunarathna U., Kongsema M., Zona S., Gong C., Cabrera E., Gomes A.R., Man P.S., Khongkow P., Tsang J.W.H., Khoo U.S., Medema R.H., Freire R. and Lam E.W., OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance, Oncogene. 2015.
Lam W.W.T., Liao Q., Wong J.H.F., Lai C.L., Yuen R.M.F., Tsang J.W.H. and Fielding R., Measuring and validating a general cancer predisposition perception scale: an adaptation of the revised-IPQ-genetic predisposition scale, PLoS One. 2015, 10: e0142620.


Researcher : Tsang WHJ
Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:10/2008


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang WHJ, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):Tsang WHJ, Khoo US
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


Project Title:Personalized Medicine for Elderly Breast Cancer Patients (CRF)
Investigator(s):Tsang WHJ
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:01/2015
Completion Date:02/2016


List of Research Outputs

Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang W.H.J., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2016, 25(1): 58-65.
ZHANG N., Fielding R., Soong I., Chan K.K.L., Tsang W.H.J., Lee V.H.F., Lee C., Ng A., Sez W.K., Tin S.P.P. and Lam W.W.T., Illness perceptions among cancer survivors, Supportive Care in Cancer. Springer, 2016, 24(3): 1295-1304.


Researcher : WANG Y
List of Research Outputs

QU X., WANG K., DONG W., SHEN H.C., WANG Y., LIU Q. and DU J.J., Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis, Scientific Reports. 2016, 6: 20149.
WANG K., QU X., WANG Y., SHEN H.C., LIU Q. and DU J.J., Effect of mu Agonists on Long-Term Survival and Recurrence in Nonsmall Cell Lung Cancer Patients, Medicine. 2015, 94: e1333.
WANG K., QU X., WANG Y., DONG W., SHEN H.C., ZHANG T.H., NI Y., LIU Q. and DU J.J., The Impact of Ramucirumab on Survival in Patients with Advanced Solid Tumors: A Systematic Review and Meta-Analysis of Randomized II/III Controlled Trials, Clinical Drug Investigation. 2016, 36: 27-39.
WANG Y., QU X. and SHEN H.C., Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis, Asian Pac J Cancer Prev. 2015,16(11): 4759-68. 2015.
WANG Y. and YU H.W., 高脂血症动物模型研究进展, 中国老年学杂志，2015；10(35):5654-5657. 2015.


Researcher : Wong WY
List of Research Outputs

Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
PHOON Y.P., Cheung A.K.L., Cheung F.M.F., Chan K.F., Wong S., Wong W.Y., Tung S.Y., Yau C.C., Ng W.T. and Lung M.L., IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling , International Journal of Cancer. 2016, 138: 160-170.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Wu VWC
List of Research Outputs

Yuan C., Yip S.P., Wu V.W.C., Kwong D.L.W., Cheuk I.W. and Ying M., Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma, Radiation Oncology. 2015, 10: 39.


Researcher : Yau CC
List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.


Researcher : Yau TK
List of Research Outputs

Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang W.H.J., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2016, 25(1): 58-65.


Researcher : Yu Z
Project Title:Functional and mechanistic analysis of PHF11 in esophageal squamous cell carcinoma epigenetics
Investigator(s):Yu Z, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2015


Project Title:AACR Annual Meeting 2016; Differential expression and functional impact of the alternatively spliced transcripts of Extracellular matrix protein 1 in esophageal squamous cell carcinoma
Investigator(s):Yu Z
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2016
Completion Date:04/2016


List of Research Outputs

Ng H.Y., Ko J.M.Y., Yu Z., Ip J.C.Y., Dai W., Cal S. and Lung M.L., DESC1, a novel tumor suppressor, sensitises cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma, International Journal of Cancer. 2016, 138: 2940-2951.
Yu Z., Ko J.M.Y., Law S.Y.K., Wang L.D. and Lung M.L., Differential expression and functional impact of the alternatively spliced transcripts of ECM1 in esophageal squamous cell carcinoma, 107th American Association for Cancer Research. 2016.
Yu Z., Wong V.C., Dai W., Ko J.M.Y., Lam A.K., Chan K.W., Samant R.S., Lung H.L., SHUEN W.H., Law S.Y.K., Chan Y.P., Lee N.P.Y., Tong D.K.H., Law T.T., Lee V.H.F. and Lung M.L., Nuclear Localization of DNAJB6 is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells, In: Asma Nusrat Bishr Omary, Gastroenterology. 2015.


Researcher : Yuen KK
List of Research Outputs

Chan W.L.W., Lam K.O., Siu W.K.S. and Yuen K.K., Chemotherapy at end-of-life: an integration of oncology and palliative team, Supportive Care in Cancer. 2016, 24: 1421.


Researcher : ZHANG L
List of Research Outputs

TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.
Zhang L., Guan X. and Lee V.H.F., PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma, In: Curtis C Harris , Carcinogenesis. 2016.


Researcher : ZHENG H
List of Research Outputs

Dai W., ZHENG H., Cheung A.K.L. and Lung M.L., Genetic and epigenetic landscape of nasopharyngeal carcinoma, Chinese Clinical Oncology. 2016, 5: 16-16.
Dai W., Tang S.M., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y. and Lung M.L., Whole-exome Sequencing Identifies Genetic Susceptibility Locus Associated With Familial Nasopharyngeal Carcinoma, 17th International Symposium On Ebv And Associated Diseases. 2016.
Dai W., ZHENG H., Cheung A.K.L., Tang S.M., Ko J.M.Y., Wong W.Y., LEONG M.L., Sham P.C., Cheung M.F.F., Kwong D.L.W., Ngan K.C., Ng W.T., Yau C.C., Chiang A.K.S., Lee W.M.A., Lee V.H.F., Lam K.O., Au G.K.H. and Lung M.L., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma , Proceedings of the National Academy of Sciences. 2016, 113: 3317-3322.
ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Au K.H., Cheng H.C., Yiu H.H.Y. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations in the NFkB pathways regulators in NPC, 107th American Association for Cancer Research. 2016.


Researcher : Zhang L
Project Title:20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine; Reduced expression of PSCA, a novel tumor suppressor gene, is regulated by transcription factor SOX5 in esophageal squamous cell carcinoma
Investigator(s):Zhang L
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2015
Completion Date:10/2015


List of Research Outputs

TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016.
Zhang L., Guan X. and Lee V.H.F., PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma, In: Curtis C Harris , Carcinogenesis. 2016.


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