CENTRE FOR GENOMIC SCIENCES
| Researcher : Gui H |
| Project Title: | Identification for epilepsy-schizophrenia genetic sharing through multiple data mining approaches |
| Investigator(s): | Gui H, Cherny SS, Li M, Sham PC |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Researcher : Li J |
| Project Title: | American Society of Human Genetics (ASHG) 2016 Annual Meeting; Cell type-specific annotation and prioritization of regulatory variants |
| Investigator(s): | Li J |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2016 |
| Completion Date: | 10/2016 |
| List of Research Outputs |
| Li J., Li J., Liu Z., Yan B., Pan Z., Huang D., Liang Q., Ying D., Xu F., Yao H., Wang P., Kocher J.A., Xia Z., Sham P.C., Liu J.S. and Wang J.J., cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes, Genome Biol. 2017, 18(1): 52. |
| Li J., Yao H., Huang D., Liu H., Liu Z., Xu H., Qin Y., Prinz J., Xia W., Wang P., Yan B., Tran N.L., Kocher J.P., Sham P.C. and Wang J.J., mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers, Nucleic Acids Res. 2017. |
| Li M., LI J., Li J., Pan Z., HSU S.J., Liu D., Zhan X., Wang J.J., Song Y. and Sham P.C., Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework, Nucleic Acids Res. 2017, 45(9): e75. |
| Researcher : Liang Y |
| List of Research Outputs |
| CHENG L.Y., Lau K.W.W., Fung T.K.H., Lau B.W.M., Chau B.K.H., Liang Y., Wang Z., So K.F., Wang T., Chan C.C.H. and Lee T.M.C., PM2.5 Exposure Suppresses Dendritic Maturation in Subgranular Zone in Aged Rats, Neurotoxicity Research. 2017. |
| RAO Y., Liang Y. and PENG B., A revisit of rod microglia in preclinical studies, Neural Regeneration Research. 2017, 0: 0. |
| Researcher : Lin C |
| List of Research Outputs |
| Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016. |
| Researcher : Mak SHT |
| Project Title: | ASHG2016; Polygenic scores using summary statistics via penalized regression |
| Investigator(s): | Mak SHT |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2016 |
| Completion Date: | 10/2016 |
| List of Research Outputs |
| Ho C., Tai S., Lee E.C., Mak S.H.T., Liu T.K., Tang V.W. and Poon W.T., Rapid Identification of Pathogenic Variants in Two Cases of Charcot-Marie-Tooth Disease by Gene-Panel Sequencing, International Journal of Molecular Sciences. 2017, 18: 770. |
| Mak S.H.T., Kwan S.H., Campbell D.D. and Sham P.C., Local True Discovery Rate Weighted Polygenic Scores Using GWAS Summary Data, Behavior Genetics. Springer US, 2016, 46: 573-582. |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Partner State Key Laboratory of Brain and Cognitive Sciences |
| Investigator(s): | Sham PC, So KF, Tan L |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 10/2008 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | Genomics |
| Investigator(s): | Sham PC, Chin FYL, Leung FCC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Cross Cultural Differences in Biased Cognition |
| Investigator(s): | Sham PC, Chen EYH, Toulopoulou T |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | ESRC/RGC Joint Research Scheme |
| Start Date: | 09/2013 |
| Project Title: | Mutational spectrum for dilated cardiomyopathy in Hong Kong |
| Investigator(s): | Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Completion Date: | 03/2017 |
| Project Title: | A novel computational framework to identify transcription factor-DNA interaction for cancer genomics |
| Investigator(s): | Sham PC, Yao KM, Wong MP, Wang JJ |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2014 |
| Project Title: | Schizophrenia-related de novo and compound heterozygous mutations |
| Investigator(s): | Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Method and software tool for estimating and dissecting the heritability of complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Project Title: | Establishment of Third Generation Sequencing Core Facility |
| Investigator(s): | Sham PC, Leung SY, Peiris JSM, Poon LML, Woo PCY, Yuen KY |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 04/2017 |
| List of Research Outputs |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017. |
| Li J., Li J., Liu Z., Yan B., Pan Z., Huang D., Liang Q., Ying D., Xu F., Yao H., Wang P., Kocher J.A., Xia Z., Sham P.C., Liu J.S. and Wang J.J., cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes, Genome Biol. 2017, 18(1): 52. |
| Li J., Yao H., Huang D., Liu H., Liu Z., Xu H., Qin Y., Prinz J., Xia W., Wang P., Yan B., Tran N.L., Kocher J.P., Sham P.C. and Wang J.J., mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers, Nucleic Acids Res. 2017. |
| Li T.H., Qin Y., Sham P.C., Lau K.S., Chu K.M. and Leung W.K., Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis, Scientific Reports. 2017, 7: 44935. |
| Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017. |
| Mak S.H.T., Kwan S.H., Campbell D.D. and Sham P.C., Local True Discovery Rate Weighted Polygenic Scores Using GWAS Summary Data, Behavior Genetics. Springer US, 2016, 46: 573-582. |
| So H.C. and Sham P.C., Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits, Bioinformatics. 2017, 33: 886-890. |
| So H.C. and Sham P.C., Improving polygenic risk prediction from summary statistics by an empirical Bayes approach, Scientific Reports. 2017, 7: 41262. |
| Yang Z., Li M., Hu X., Xiang B., Deng W., Wang Q., Wang Y., Zhao L., Ma X., Sham P.C., Northoff G. and Li T., Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia, Translational Psychiatry. 2017, 7: e1028. |
| Researcher : Wang JJ |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| List of Research Outputs |
| LAI Y.T., YANG Y., Hu L., Cheng T., CHANG Y.Y., KOOHIMOGHADAM M., WANG Y., Xia J., Wang J.J., Li H. and Sun H., Integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells, Metallomics. 2017, 9: 38-47. |
| Li J., Li J., Liu Z., Yan B., Pan Z., Huang D., Liang Q., Ying D., Xu F., Yao H., Wang P., Kocher J.A., Xia Z., Sham P.C., Liu J.S. and Wang J.J., cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes, Genome Biol. 2017, 18(1): 52. |
| Li J., Yao H., Huang D., Liu H., Liu Z., Xu H., Qin Y., Prinz J., Xia W., Wang P., Yan B., Tran N.L., Kocher J.P., Sham P.C. and Wang J.J., mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers, Nucleic Acids Res. 2017. |
| Li M., LI J., Li J., Pan Z., HSU S.J., Liu D., Zhan X., Wang J.J., Song Y. and Sham P.C., Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework, Nucleic Acids Res. 2017, 45(9): e75. |
| WANG Y., Hu L., Xu F., QUAN Q., Lai Y.T., Xia W., YANG Y., CHANG Y.Y., Yang X., Chai Z., Wang J.J., Chu I.K., Li H. and Sun H., Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori, Chemical Science. Royal Society of Chemistry, 2017, 8: 4626-4633. |
| Researcher : Wang P |
| List of Research Outputs |
| Li J., Li J., Liu Z., Yan B., Pan Z., Huang D., Liang Q., Ying D., Xu F., Yao H., Wang P., Kocher J.A., Xia Z., Sham P.C., Liu J.S. and Wang J.J., cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes, Genome Biol. 2017, 18(1): 52. |
| Li J., Yao H., Huang D., Liu H., Liu Z., Xu H., Qin Y., Prinz J., Xia W., Wang P., Yan B., Tran N.L., Kocher J.P., Sham P.C. and Wang J.J., mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers, Nucleic Acids Res. 2017. |
| Researcher : Xu F |
| List of Research Outputs |
| WANG Y., Hu L., Xu F., QUAN Q., Lai Y.T., Xia W., YANG Y., CHANG Y.Y., Yang X., Chai Z., Wang J.J., Chu I.K., Li H. and Sun H., Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori, Chemical Science. Royal Society of Chemistry, 2017, 8: 4626-4633. |