Dept of Clinical Oncology

DEPT OF CLINICAL ONCOLOGY

Researcher : Au SK

List of Research Outputs

Wang Q., Guo W., Hao B., Shi X., Lu Y., Wong W.M., Ma V.W., Yip T.T., Au S.K., Hao Q., Cheung K.H., Wu W., Li G.R. and Yue J., Mechanistic study of TRPM2-Ca 2+ -CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition , Autophagy. 2016, 12: 1340-1354.

Researcher : CHAI WY

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional Analysis of a Basement Membrane Protein, Nidogen-2 (NID2), in Nasopharyngeal Carcinoma and Esophageal Squamous Cell Carcinoma, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional analysis of a basement membrane protein, Nidogen-2 (NID2) in NPC and ESCC, Sydney Cancer Conference, Australia, September 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Researcher : CHAN HM

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Researcher : CHEN J

List of Research Outputs

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Researcher : Cao T

List of Research Outputs

Cao T., Lin S.H., Fu L., Tang Z., Che C.M., Zhang L., Ming X., Liu T.F., Tang X.M., Tan B.B., Xiang D., Li F., Chan O.Y., Xie D., Cai Z. and Guan X., Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells, Carcinogenesis. 2017, 38: 94-104.

Fu L., Qin Y.R., Ming X., Zuo X.B., Diao Y.W., Zhang L., Ai J., Liu B.L., Huang T.X., Cao T., Tan B.B., Xiang D., Zeng C.M., Gong J., Zhang Q., Dong S., Chen J., Liu H., Wu J.L., Qi R.Z., Xie D., Wang L.D. and Guan X., RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer, Pro Nat Aca Sci USA. 2017, 114: E4631-4640.

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Researcher : Chan KC

List of Research Outputs

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

Researcher : Chan OSH

List of Research Outputs

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Lee W.M.A., Ng W.T., Ngan K.C., Chan O.S.H., Sze C.K.H. and Chan J.Y.W., Management of nasopharyngeal carcinoma, In: J. Bernier, Head and Neck Cancer: Multimodality Management. 2nd edition. Springer, 2016, 445-473.

Researcher : Chan WLW

List of Research Outputs

Law T.T., Lam K.O., Tong D.K.H., Chan W.L.W., Chan K.K., Wong I.Y.H., Chan S.Y., Kwong D.L.W. and Law S.Y.K., CROSS Neoadjuvant Chemoradiotherapy in Locally Advanced Squamous Cell Cancer of the Oesophagus: Application beyond CROSS criteria, International Society for Diseases of The Esophagus 2016.

Law T.T., Lam K.O., Tong K.H.D., Chan W.L.W., Chan K.K.D., Wong Y.H.I., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Neoadjuvant chemoradiotherapy in locoregionally advanced squamous cell cancer of the oesophagus: beyond CROSS?, Poster Session 2, the 15th World Congress of the International Society for Diseases of the Esophagus (ISDE 2016), Singapore, 19-21 September 2016. Abstract (No: PS02.077) in Diseases of the Esophagus. 2016, 29 (Suppl S1): 128A-129A.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

Researcher : Chang TYA

List of Research Outputs

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Lee V.H.F., Lee W.M.A., Chang T.Y.A. and Ng W.T., Evidenced-Based Management of Nasopharyngeal Cancers in the Modern Era, Chemoradiotherapy: Concurrent Uses, Efficacy and Impact on Prognosis. 2017, 1-34.

Researcher : Chau WY

List of Research Outputs

Lung H.L., Chau W.Y., Lee N.P.Y., Law S.Y.K. and Lung M.L., Early detection and prognosis of esophageal squamous cell carcinoma (ESCC) using the circulating plasma SAA protein and the SAA1 polymorphisms (Abstract), Health Research Symposium 2017, Hong Kong, 16 June 2017.

Researcher : Cheung AKL

Project Title:	Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):	Cheung AKL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

Project Title:	Elucidation of the role of Epstein-Barr Virus in modulating DNA damage repair and cancer-associating signaling pathways via bivalent H3K4me3 and H3K27me3 histone modifications in nasopharyngeal epithelial and cancer cells
Investigator(s):	Cheung AKL, Lung ML, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017
Completion Date:	06/2016

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional Analysis of a Basement Membrane Protein, Nidogen-2 (NID2), in Nasopharyngeal Carcinoma and Esophageal Squamous Cell Carcinoma, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional analysis of a basement membrane protein, Nidogen-2 (NID2) in NPC and ESCC, Sydney Cancer Conference, Australia, September 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Cheung FY

List of Research Outputs

LEE F.A.S., ZEE B.C.Y., Cheung F.Y., Kwong W.K.P., Chiang C.L., LEUNG K.C., Siu W.K.S., Lee C.C.Y., LAI M., KWOK C., CHONG M., JOLIVET J. and TUNG S., Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC), American Journal of Clinical Oncology. 2016, 39: 609-613.

Researcher : Chiang CL

Project Title:	ESTRO 36; EBRT and HDBRT in Rectal Cancer Patients who are medically unfit or refuse surgery
Investigator(s):	Chiang CL
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

List of Research Outputs

CHAN M., Chiang C.L., LEE V., CHEUNG S., LEUNG R., WONG M., LEE F., BLANCK O. and ZHANG Q.H., Target localization of 3D versus 4D cone beam computed tomography in lipiodol-guided stereotactic radiotherapy of hepatocellular carcinomas, PLOS ONE. 2017, 12: e0174929.

Chan M.K.H., Chiang C.L., Leung R.W.K., Wong M.Y.P. and Blanck O., Modeling Clinical Outcome of Combined Transarterial Chemoembolization Stereotactic Body Radiotherapy of Hepatocellular Carcinoma using Mid-Ventilation Planning Target Volume Concept with 4D Cone Beam Computed Tomography, DEGRO, 15 June 2017, Berlin, Germany. 2017.

Chiang C.L., Yeung C.S.Y., Ho C.H.M., Choi C.K.K. and Lee A.S., Combined Transarterial Chemoembolization (TACE) and Stereotactic Body Radiotherapy (SBRT) In HKLC Intermediate And Locally Advanced Hepatocellular Carcinoma (HCC), 7th Asia-Pacific Primary Liver Cancer Expert Meeting, 9 July 2016, Hong Kong. 2016.

Chiang C.L., Combined immunotherapy and radiotherapy, Hong Kong medical diary. 2017, 22(6).

Chiang C.L., Lee V.W.Y., Yeung C.S.Y., Wong M.Y.P. and Lee F.A.S., External Beam Radiotherapy (EBRT) And High Dose Rate Brachytherapy (HDRBT) in Rectal Cancer Patients Who Are Medically Unfit Or Refuse Surgery, Radiotherapy Oncology. 2017.

Chiang C.L., Management of metastatic colorectal cancer, Precision Oncology Symposium, Hong Kong, 15 June, 2017. 2017.

Chiang C.L., Non-surgical management of Pancreatic Cancer, HBP Surgical Nursing Seminar, Hong Kong, 26 November 2016. 2016.

Chiang C.L., Lee A.S., Choi K.K., Yeung S.Y., Wong Y.P., Leung W.K., Lee W.Y., Chan K.H. and Tung Y., Stereotactic Body Radiation Therapy (SBRT) Combined With Transarterial Chemoembolization (TACE) in BCLC Stage B and C Hepatocellular Carcinoma (HCC), Int J Radiat Oncol Biol Phys. 2016, 96(2): supplement: E162.

Choi K.K., Lee A.S., Chiang C.L., Wong F.C.S., Sze C.K.H. and Tung S.Y., The Efficacy, Toxicities and Prognostic Factors of Stereotactic Radiotherapy in Locally Advanced Unresectable Hepatitis B Related Hepatocellular Carcinoma, 7th Asia-Pacific Primary Liver Cancer Expert Meeting, 9 July 2016, Hong Kong. 2016.

LEE F.A.S., ZEE B.C.Y., Cheung F.Y., Kwong W.K.P., Chiang C.L., LEUNG K.C., Siu W.K.S., Lee C.C.Y., LAI M., KWOK C., CHONG M., JOLIVET J. and TUNG S., Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC), American Journal of Clinical Oncology. 2016, 39: 609-613.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

Yeo W., Lam K.O., Law A.L., Chiang C.L., Lee C.C. and Au K.H., Author's reply: Adjuvant S-1 chemotherapy after curative resection of gastric cancer in Chinese patients: assessment of treatment tolerability and associated risk factors., Hong Kong Medical Journal. 2017, 23: 315-6.

Researcher : Choi CW

List of Research Outputs

Lam K.O., Lau J., Lam K., Yuen A., Kwok H., Tam F.K., Choi C.W., Lee V.H.F. and Leung T.W., A Comparison of Cetuximab with Oral versus Infusional Fluoropyrimidine in Chinese Patients in the Community Setting, The 24th Asia Pacific Cancer Conference in conjunction with the 43rd Annual Meeting of Korean Cancer Association. 2017.

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee W.M.A., Tung S.Y., Ng W.T., Lee V.H.F., Ngan R.K.C., Choi C.W., Chan L.L.K., Siu L.L., Ng A.W.Y., Leung T.W., Yiu H.H.Y., O'Sullivan B. and Chappell R., A multicenter, phase 3, randomized trial of concurrent chemoradiotherapy plus adjuvant chemotherapy versus radiotherapy alone in patients with regionally advanced nasopharyngeal carcinoma: 10-year outcomes for efficacy and toxicity, Cancer. 2017.

Pan J.J., Ng W.T., Zong J.F., Lee S.W., Choi C.W., Chan L.L., Lin S.J., Guo Q.J., Sze H.C., Chen Y.B., Xiao Y.P., Kan W.K., O'Sullivan B., Xu W., Le Q.T., Glastonbury C.M., Colevas A.D., Weber R.S., Lydiatt W., Shan J.P. and Lee W.M.A., Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy, In: American Cancer Society, Cancer. 2016.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

Researcher : Chow KKR

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Researcher : Chua DTT

Project Title:	2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2000

Project Title:	2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2004

Researcher : DENG M

List of Research Outputs

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Dai W

Project Title:	Establishment of Gene Panel for Predicting Platinum-based Chemoresistance in Cancers
Investigator(s):	Dai W, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional Analysis of a Basement Membrane Protein, Nidogen-2 (NID2), in Nasopharyngeal Carcinoma and Esophageal Squamous Cell Carcinoma, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional analysis of a basement membrane protein, Nidogen-2 (NID2) in NPC and ESCC, Sydney Cancer Conference, Australia, September 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Fu L

List of Research Outputs

Cao T., Lin S.H., Fu L., Tang Z., Che C.M., Zhang L., Ming X., Liu T.F., Tang X.M., Tan B.B., Xiang D., Li F., Chan O.Y., Xie D., Cai Z. and Guan X., Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells, Carcinogenesis. 2017, 38: 94-104.

Fu L., Qin Y.R., Ming X., Zuo X.B., Diao Y.W., Zhang L., Ai J., Liu B.L., Huang T.X., Cao T., Tan B.B., Xiang D., Zeng C.M., Gong J., Zhang Q., Dong S., Chen J., Liu H., Wu J.L., Qi R.Z., Xie D., Wang L.D. and Guan X., RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer, Pro Nat Aca Sci USA. 2017, 114: E4631-4640.

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Researcher : Guan X

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011
Completion Date:	11/2016

Project Title:	A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):	Guan X, Zhang M
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2012
Completion Date:	02/2017

Project Title:	Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013
Completion Date:	12/2016

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):	Guan X, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	02/2017

Project Title:	Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

Bao Y., Liu J., You J., Wu D., Yu Y., Liu C., Wang L., Wang F., Xu L., Wang L., Wang N., Tian X., Wang F., Liang H., Gao Y., Cui X., Ji G., Bai J., Yu J., Meng X., Jin Y., Sun W., Guan X., Zhang C. and Fu S., Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts, Oncotarget. 2016, 7: 56664-56675.

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Cao R., Meng Z., Liu T., Wang G., Qian G., Guan X., Dan H., Xiao Y. and Wang X., Decreased TRPM7 inhibits activities and induces apotosis of bladder cancer cells via ERK1/2 pathway, Oncotarget. 2016, 7: 72941-72960.

Cao T., Lin S.H., Fu L., Tang Z., Che C.M., Zhang L., Ming X., Liu T.F., Tang X.M., Tan B.B., Xiang D., Li F., Chan O.Y., Xie D., Cai Z. and Guan X., Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells, Carcinogenesis. 2017, 38: 94-104.

Chen M. and Guan X., Characterize the role of cancer associated fibroblast (CAFs) derived IL‐32 in esophageal squamous cell carcinoma (ESCC)., The American Association of Immunologists Annual Meeting 2017, May 12-16, Washington, D.C.. 2017.

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Fang S., Li L., Liu M. and Guan X., LEF1 negatively regulates differentiation of hepatocellular carcinoma via activation of NOTCH signaling pathway, AACR 108th Annul Meeting; April 2017, San Diego, USA. 2017.

Fu L., Qin Y.R., Ming X., Zuo X.B., Diao Y.W., Zhang L., Ai J., Liu B.L., Huang T.X., Cao T., Tan B.B., Xiang D., Zeng C.M., Gong J., Zhang Q., Dong S., Chen J., Liu H., Wu J.L., Qi R.Z., Xie D., Wang L.D. and Guan X., RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer, Pro Nat Aca Sci USA. 2017, 114: E4631-4640.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Huang P.Y., Zeng T., Ban X., Li M.Q., Zhang B.Z., Zhu Y.H., Hua W.F., Mai H.Q., Zhang L., Guan X. and Li Y., Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy, BMC Cancer. 2016, 16: 669.

Jiang L., Liu M., Li Y., Kwong D.L.W. and Guan X., Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway, 钙结合蛋白39通过ERK信号通路促进肝癌细胞的转移, In: David E. Cohen, Hepatology. 2017.

Jiang L., YAN Q., WANG X., Shi C. and Guan X., Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model, 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia. 2017.

LUK T.C.S., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Li B., XU W., Lam A.K.Y., Wang Y.A.N.G., Hu H.-.F., Guan X., Qin Y.R., Saremi N., Tsao G.S.W., He Q.-.Y. and Cheung A., Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy, Oncotarget. 2017, 8: 38755-38766.

Li J., Zhang B.Z., Qin Y.R., Bi J., Liu H.B., Li Y., Ma S.K.Y., Chan K.W., Xie D. and Guan X., CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction, Oncotarget. 2016, 7: 15525-38.

Li L., Zhu Y.H., Li Y. and Guan X., Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma, Neoplasma. 2017.

Li X.D., Zhang J.X., Jiang L.J., Wang F.W., Liu L.L., Laio Y.J., Jin X.H., Chen W.H., Chen X., Guo S.J., Zhou F.J., Zeng Y.X., Guan X., Liu Z.W. and Xie D., Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically down-regulating MTSS1 through DNMT3B, Oncogene. 2016, 35: 6281-6292.

Lyu Z., Wu S., Cai Z. and Guan X., Patient-physician trust in China: health education for the public, Lancet. 2016, 388: 2991.

Mao X., Guan X. and Yam J.W.P., Role of caveolin-1 in hepatitis B virus-induced hepatocarcinogenesis, Health Research Symposium 2017.

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Peng F., Tang H., Liu P., Guan X., XIe X., Gao J., Xiong L. and Peng C., Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis., Scientific Reports . 2017, 2017:7(1): 9022.

Qi J., Zhang L. and Guan X., Exploring the mechanism for cancer associated fibroblasts recruitment and the potential therapeutic value in esophageal squamous cell carcinoma, International Congress of Immunology 2016; Aug 21-26, 2016, Melbourne, Australia. 2016.

Qian K., Wang G., Cao R., Liu T., Qian G., Guan X., Guo Z., Xiao Y. and Wang X., Capsaicin induces dysregulation of proliferation, cell cycle and ROS metabolism by interfering FOXO3a in bladder cancer cells in vivo and in vitro, Molecules. 2016, 21: 1406.

Stunnenberg H.G., Hirst M., Abrignani S., Adams D., de Almeida M., Altucci L., Amin V., Amit I., Aparicio S., Aparicio S., Arima T., Arrigoni L., Arts R., Asnafi V., Esteller M., Bae J.B., Bassler K., Beck S., Berkman B., Bernstein B.E., Bilenky M., Bird A., Bock C., Boehm B., Bourque G., Breeze C.E., Brors B., Bujold D., Burren O., Bussemakers M.J., Butterworth A., Campo E., Carrillo-de-Santa-Pau E., Chadwick L., Chan K.M., Chen W., Cheung T.H., Chiapperino L., Choi N.H., Chung H.R., Clarke L., Connors J.M., Cronet P., Danesh J., Dermitzakis M., Drewes G., Durek P., Dyke S., Dylag T., Eaves C.J., Ebert P., Eils R., Eils J., Ennis C.A., Enver T., Feingold E.A., Felder B., Ferguson-Smith A., Fitzgibbon J., Flicek P., Foo R.S.Y., Fraser P., Frontini M., Furlong E., Gakkhar S., Gasparoni, N., Gasparoni G., Geschwind D.H., Glažar P., Graf T., Grosveld F., Guan X., Guigo R., Gut I.G., Hamann A., Han B.G., Harris R.A., Heath S., Helin K., Hengstler J.G., Heravi-Moussavi A., Herrup K., Hill S., Hilton J.A., Hitz B.C., Horsthemke B., Hu M., Hwang J.Y., IP N.Y., ITO T., Javierre B.M., Jenko S., Jenuwein T., Joly Y., Jones S.J.M., Kanai Y., Kang H.G., Karsan A., Kiemer A.K., KIM S.C., KIM B.J., KIM H.H., Kimura H., Kinkley S., Klironomos F., Koh I.U., Kostadima M., Kressler C., Kreuzhuber R., Kundaje A., Küppers R., Larabell C., Lasko P., Lathrop M., Lee D.H.S., LEE S., Lehrach H., Leitão E., Lengauer T., Lernmark A., Leslie R.D., Leung G.K.K., Leung D., Loeffler M., Ma Y., Mai A., Manke T., Marcotte E.R., Marra M.A., Martens J.H.A., Martin-Subero J.I., Maschke K., Merten, C., Milosavljevic A., Minucci S., Mitsuyama T., Moore R.A., Müller F., Mungall A.J., Netea M.G., Nordström K., Norstedt I., Okae H., Onuchic V., Ouellette F., Ouwehand W., Pagani M., Pancaldi V., Pap T., Pastinen T., Patel R., Paul D.S., Pazin M.J., Pelicci P.G., Phillips A.G., Polansky J., Porse B., Pospisilik J.A., Prabhakar S., Procaccini D.C., Radbruch A., Rajewsky N., Rakyan V., Reik W., Ren B., Richardson D., Richter A., Rico D., Roberts D.J., Rosenstiel P., Rothstein M., Salhab A., Sasaki H., Satterlee J.S., Sauer S., Schacht C., Schmidt F., Schmitz G., Schreiber S., Schröder C., Schübeler D., Schultze J.L., Schulyer R.P., Schulz M., Seifert M., Shirahige K., Siebert, R., Sierocinski, T., Siminoff, L., Sinha A., Soranzo N., Spicuglia S., Spivakov M., Steidl C., Strattan J.S., Stratton M., Südbeck P., Sun H., Suzuki N., Suzuki Y., Tanay A., Torrents D., Tyson, F.L., Ulas T., Ullrich S., Ushijima T., Valencia A., Vellenga E., Vingron M., Wallace C., Wallner S., Walter J., Wang H.T., Weber S., Weiler N., Weller A., Weng A., Wilder S., Wiseman S.M., Wu A.R., Wu Z.G., Xiong J.Y., Yamashita Y. and Yang X.Y., Yap D.Y., Yip K.Y., Yip S., Yoo J.L., Zerbino D., Zipprich G., The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery, Cell. 2016, 167: 1145-1149.

Tang H., Wu Y., Qin Y., Wang H., Wang L., Guan X., Luo S. and Wang Q., Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in northern China, Onco Targets Ther. 2016, 10: 85-94.

Tang P.M., Zhou S., Meng X.M., Wang Q.M., Li C.J., Lain G.Y., Huang X.R., Tang Y.J., Guan X., Yan B.P., To K.F. and Lan H.Y., Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development, Nature Communications. 2017, 8: 14677.

Tian B.Q., Chen X.J., Zhang H.H., Li X.Y., Wang J.K., Han W., Zhang L., Fu L., Li Y., Nie C.J., Zhao Y., Tan X., Wang H.L., Guan X. and Hong A., Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma, Oncotarget. 2017.

WANG X., Jiang L., Shi C., Chen H. and Guan X., Characterization of a stemness-related gene RALYL in the development and progression of hepatocellular carcinoma, 3rd EACR Conference on Cancer Genomics; June 25-28, 2017, Cambridge, UK. 2017.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

You J., Liu J., Bao Y., Wang L., Yu Y., Wang L., Wu D., Liu C., Wang N., Wang F., Wang F., Xu L., Tian X., Liang H., Gao Y., Guan R., Bai J., Meng X., Sun W., Guan X., Zhang C., Fu S. and Jin Y., SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer, Cancer Letter. 2017, 385: 271-279.

Researcher : Guan X.

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011
Completion Date:	11/2016

Project Title:	A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):	Guan X, Zhang M
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2012
Completion Date:	02/2017

Project Title:	Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013
Completion Date:	12/2016

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):	Guan X, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	02/2017

Project Title:	Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

Researcher : Guan XY

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011
Completion Date:	11/2016

Project Title:	A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):	Guan X, Zhang M
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2012
Completion Date:	02/2017

Project Title:	Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013
Completion Date:	12/2016

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):	Guan X, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	02/2017

Project Title:	Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

Researcher : Ho PYP

List of Research Outputs

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Researcher : Ip JCY

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Researcher : Jiang L

Project Title:	2017 Lorne Genome Conference; Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model
Investigator(s):	Jiang L
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2017
Completion Date:	02/2017

List of Research Outputs

Jiang L., Liu M., Li Y., Kwong D.L.W. and Guan X., Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway, 钙结合蛋白39通过ERK信号通路促进肝癌细胞的转移, In: David E. Cohen, Hepatology. 2017.

Jiang L., YAN Q., WANG X., Shi C. and Guan X., Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model, 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia. 2017.

WANG X., Jiang L., Shi C., Chen H. and Guan X., Characterization of a stemness-related gene RALYL in the development and progression of hepatocellular carcinoma, 3rd EACR Conference on Cancer Genomics; June 25-28, 2017, Cambridge, UK. 2017.

Researcher : KAN PQR

List of Research Outputs

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Kam NW

Project Title:	AACR Annual Meeting 2017 ; Cross talk between tumor cell derived HMGB1 and adaptive B cells in the tumor microenvironment of esophageal squamous cell carcinoma
Investigator(s):	Kam NW
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Researcher : Ko JMY

Project Title:	The clinical relevance of telomere attrition and NPC genetic susceptibility
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

Project Title:	Validation and functional characterization of candidate genetic susceptibility loci and the inherited risk for familial esophageal squamous cell carcinoma (ESCC)
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2015

Project Title:	Genomic and functional study of rare deleterious germline mutations in RAD50 associated with familial risk for esophageal carcinoma
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional Analysis of a Basement Membrane Protein, Nidogen-2 (NID2), in Nasopharyngeal Carcinoma and Esophageal Squamous Cell Carcinoma, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional analysis of a basement membrane protein, Nidogen-2 (NID2) in NPC and ESCC, Sydney Cancer Conference, Australia, September 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

NING L., Ko J.M.Y. and Lung M.L., Genetic Susceptibility of Familial Esophagus Squamous Cell Carcinomas (ESCC) by Target Sequencing for Germline Rare Deleterious Variants, 24th Asia Pacific Cancer Conference (APCC 2017), Seoul, Korea. June 22-24, 2017.. 2017.

Wong V.C., Ko J.M.Y., Lam C.T. and Lung M.L., Succinct workflows for circulating tumor cells after enrichment: from systematic counting to mutational profiling. , PLOS One. 2017, 12.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Kwok CTT

List of Research Outputs

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Kwong DLW

Project Title:	Knowledge and Technology Transfer through Advanced Training in Clinical Immunotherapy for Nasopharyngeal Carcinoma and other Virus Associated Malignancies
Investigator(s):	Kwong DLW, Nicholls JM
Department:	Clinical Oncology
Source(s) of Funding:	Zeshan (HK) Foundation
Start Date:	01/2016

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Ho S., Ip W., Chu S., Chan S., Lee B., Chan B., Lee J., Flynn B., Ho W., Sin J., Kwong D.L.W., Leung T.W. and Lam K.O., Treatment Regret in Long-term Survivors of Nasopharyngeal Carcinoma Treated with Radical Radiotherapy, Clinical Oncology. 2017, 29: e47.

Huang B., Kwong D.L.W., Lai V., Chan Q., Whitcher B. and Khong P.L., Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Regional Nodal Metastasis in Nasopharyngeal Carcinoma: Correlation with Nodal Staging, Contrast Media & Molecular Imaging. 2017, 2017: 1-6.

Jiang L., Liu M., Li Y., Kwong D.L.W. and Guan X., Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway, 钙结合蛋白39通过ERK信号通路促进肝癌细胞的转移, In: David E. Cohen, Hepatology. 2017.

Keefe D., AI Garni A., Villalon A., Hassan A., Kwong D.L.W., Li P., Tamura K., Kim J.H., Yusof M.M., Javed M.Z., Kanesvaran R., Hsieh R.K. and Aapro M., Challenges in supportive cancer care: perspectives from the Asia Pacific and Middle East, Supportive Care in Cancer. 2016, 24: 4479-4481.

Kwong D.L.W., Biomarkers for non-invasive early diagnosis and monitoring of nasopharyngeal carcinoma, 2016 Annual Meeting of Radiation Oncology Committee of Sichuan Medical Association, Chengdu, China. 12 August 2016. 2016.

Kwong D.L.W., Role of induction chemotherapy in the management of nasopharyngeal carcinoma, European Cancer Congress, ECCO 2017, 27-30 January Amsterdam, the Netherlands. 28 January 2017, Head and Neck Cancer Clinical Symposium: Head and Neck Cancer – Trials and Outcome Research that Change Practice. 2017.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

Lau K.S., Lam K.O., Chan W.L., Kwong D.L.W. and Leung T.W., Safety and efficacy of S-1 monotherapy and S-1-Cisplatin combination chemotherapy in the first line setting of metastatic gastric cancer – retrospective analysis in a tertiary referral centre., Hong Kong Journal of Radiology. 2016.

Law T.T., Lam K.O., Tong D.K.H., Chan W.L.W., Chan K.K., Wong I.Y.H., Chan S.Y., Kwong D.L.W. and Law S.Y.K., CROSS Neoadjuvant Chemoradiotherapy in Locally Advanced Squamous Cell Cancer of the Oesophagus: Application beyond CROSS criteria, International Society for Diseases of The Esophagus 2016.

Law T.T., Lam K.O., Tong K.H.D., Chan W.L.W., Chan K.K.D., Wong Y.H.I., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Neoadjuvant chemoradiotherapy in locoregionally advanced squamous cell cancer of the oesophagus: beyond CROSS?, Poster Session 2, the 15th World Congress of the International Society for Diseases of the Esophagus (ISDE 2016), Singapore, 19-21 September 2016. Abstract (No: PS02.077) in Diseases of the Esophagus. 2016, 29 (Suppl S1): 128A-129A.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Ng S.C.Y., Kwong D.L.W., Lam K.O. and Leung T.W., Impact of intravenous contrast used in computed tomography on radiation dose to carotid arteries and thyroid in intensity-modulated radiation therapy planning for nasopharyngeal carcinoma., Medical Dosimetry. 2017, 42: 137-144.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Lam K.O., Tong C.C. and Lee W.M.A., Palliative systemic therapy for recurrent or metastatic nasopharyngeal carcinoma – How far have we achieved?, Critical Reviews in Oncology/Hematology. 2017, 114: 13-23.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee V.H.F., Lam K.O., Kwong D.L.W. and Leung T.W., Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report, Journal of Medical Case Reports. 2016, 10.

Li W.H.C., Lam T.H., Wong C.N., Fong D.Y.T., Kwong D.L.W., Tung S.Y., Ng C.S.M. and Sarna L., Helping cancer patients quit smoking using brief risk communication and motivational counseling: A randomized controlled trial (poster and abstract), Health Research Symposium 2017, June 16, 2017, Hong Kong. 2017.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

Ng W.T., Ngan R.K.C., Lee W.M.A., Kwong D.L.W., Tung S.Y., Yuen K.T., Kam M.K., Chan L.U.C.Y. and Lung M.L., Phase II multicenter trial evaluating the role of induction TPF followed by weekly docetaxel and cetuximab in combination with IMRT for locally recurrent nasopharyngeal carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.. 2017.

Pu J., LAN X., Su Y., Pang S., Kwok V.Y.T., Tsoi K.H., QIAO W., Chan J. and Kwong D.L.W., Saliva Electrolyte Analysis Using ICP-OES in NPC Patients Following IMRT, International Association for Dental Research IADR/AADR/CADR 95th General Session and Exhibition, San Francisco, USA. 2017.

Ribassin-Majed L., Marguet S., Lee W.M.A., Ng W.T., Ma J., Chan A.T., Huang P.Y., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L.W., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzilas G., Bourhis J., Pigeon J.P. and Blanchard P., What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis, Journal of Clinical Oncology. 2017, 35: 498-505.

Rotolo F., Pignon J.P., Bourhis J., Marguet S., Lee W.M.A., Ma J., Chan A.T.C., Huang P.Y., Kwong D.L.W. and Chau D.T.T., Surrogate End Points for Overall Survival in Loco-Regionally Advanced Nasopharyngeal Carcinoma: An Individual Patient DataMeta-analysis, Journal of the National Cancer Institute. Journal of the National Cancer Institute, 2017, JNCI J Natl Cancer Inst (2017) 109(4): djw239.

Smith C., Lee V.H.F., Schuessler A., Beagley L., Rehan S., Tsang W.H.J., Li V., Tiu R., Smith D., Neller M., Matthews K.K., Gostick E., Price D.A., Burrows J., Boyle G.M., Chua D., Panizza B., Porceddu S.V., Nicholls J., Kwong D.L.W. and Khanna R., Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response, OncoImmunology. 2017, 1-9.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Kwong WKP

List of Research Outputs

LEE F.A.S., ZEE B.C.Y., Cheung F.Y., Kwong W.K.P., Chiang C.L., LEUNG K.C., Siu W.K.S., Lee C.C.Y., LAI M., KWOK C., CHONG M., JOLIVET J. and TUNG S., Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC), American Journal of Clinical Oncology. 2016, 39: 609-613.

Researcher : LEONG ML

List of Research Outputs

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Lai YC

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Researcher : Lam KO

Project Title:	PD-L1 immunohistochemical expression in esophageal cancers
Investigator(s):	Lam KO, Kwong DLW, Lee VHF, Law SYK
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

Project Title:	Improving Access to Chemotherapy in Locorgionally Advanced Esophageal and Rectal Cancer for the Poor and Sick
Investigator(s):	Lam KO, Lee VHF, So TH, Sze CKH, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2016
Completion Date:	02/2017

Project Title:	Genomic profiling of circulating tumor cells in patients undergoing liver resection for metastatic colorectal cancer
Investigator(s):	Lam KO, Lung ML, Ko JMY, Chan ACY, Lee VHF, Choi CW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Optimizing the selection of patients with metastatic colorectal cancer for liver resection – An immuno-clinical scoring system incorporating circulating tumor cell enumeration and clinical factors.
Investigator(s):	Lam KO, Lung ML, Ko JMY, Chan ACY, Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

List of Research Outputs

Ho S., Ip W., Chu S., Chan S., Lee B., Chan B., Lee J., Flynn B., Ho W., Sin J., Kwong D.L.W., Leung T.W. and Lam K.O., Treatment Regret in Long-term Survivors of Nasopharyngeal Carcinoma Treated with Radical Radiotherapy, Clinical Oncology. 2017, 29: e47.

LAU K.S., Lam K.O., CHOY T.S. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer: pattern of metastasis and sidedness of primary tumor, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Lau J., Lam K., Yuen A., Kwok H., Tam F.K., Choi C.W., Lee V.H.F. and Leung T.W., A Comparison of Cetuximab with Oral versus Infusional Fluoropyrimidine in Chinese Patients in the Community Setting, The 24th Asia Pacific Cancer Conference in conjunction with the 43rd Annual Meeting of Korean Cancer Association. 2017.

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Aflibercept in mCRC: QMH experience, Sanofi CRC symposium, Hong Kong. 2017.

Lam K.O., Anti-EGFR Treatment in mCRC: The Right Patient at the Right Time, Hong Kong International Oncology Forum 2017, Hong Kong. 2017.

Lam K.O., Gastric Cancer Education, Eli Lilly Asia, Inc. 2016.

Lam K.O., Integration of Ramucirumab into Our Practice, Battle of Gastric Cancer Symposium, Hong Kong. 2016.

Lam K.O., Managing refractory mCRC in the clinical practice, mCRC Round Table Meeting, Hong Kong. 2017.

Lam K.O., Managing refractory mCRC, Bayer Regional Oncology Training for Medical Affairs 2017, Hong Kong. 2017.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

Lam K.O., Perioperative Treatment for Gastric Cancer-Oncologist’s Perspectives, Master Workshop on Gastric Surgery, Hong Kong. 2017.

Lam K.O., Perioperative Treatment for Gastric Cancer-Oncologist’s Perspectives, The College of Surgeons of Hong Kong Lunch Symposium Series: General Surgery – Recent Advances in the Management of Gastric Cancer, Hong Kong. 2017.

Lam K.O., Personalised Treatment in Metastatic Colorectal Cancer, The 3rd Hong Kong International Oncology Symposium 2016, Hong Kong. 2016.

Lam K.O., Review and Case Sharing on TAS102, Taiho CRC Expert Meeting, Hong Kong. 2017.

Lam K.O., Strategy for Gastric Cancer with Peritoneal Metastasis- Case study, Taiho KOL Meeting, Kobe, Japan. 2016.

Lam K.O., The 7th Asia Pacific Primary Liver Cancer Expert Meeting Consensus Workshop: Respiratory Control, The 7th Asia Pacific Primary Liver Cancer Expert Meeting. 2016.

Lau K.S., Lam K.O., Chan W.L., Kwong D.L.W. and Leung T.W., Safety and efficacy of S-1 monotherapy and S-1-Cisplatin combination chemotherapy in the first line setting of metastatic gastric cancer – retrospective analysis in a tertiary referral centre., Hong Kong Journal of Radiology. 2016.

Law T.T., Lam K.O., Tong D.K.H., Chan W.L.W., Chan K.K., Wong I.Y.H., Chan S.Y., Kwong D.L.W. and Law S.Y.K., CROSS Neoadjuvant Chemoradiotherapy in Locally Advanced Squamous Cell Cancer of the Oesophagus: Application beyond CROSS criteria, International Society for Diseases of The Esophagus 2016.

Law T.T., Lam K.O., Tong K.H.D., Chan W.L.W., Chan K.K.D., Wong Y.H.I., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Neoadjuvant chemoradiotherapy in locoregionally advanced squamous cell cancer of the oesophagus: beyond CROSS?, Poster Session 2, the 15th World Congress of the International Society for Diseases of the Esophagus (ISDE 2016), Singapore, 19-21 September 2016. Abstract (No: PS02.077) in Diseases of the Esophagus. 2016, 29 (Suppl S1): 128A-129A.

Lee V.H.F., LAM T.W., NG S.C., SZETO M.H., Lam K.O. and Leung T.W., Effect of Titanium Hardware on Radiation Dosimetry in Postoperative Proton Versus Photon Spinal Stereotactic Body Radiation Therapy After Surgical Decompression for Spinal Cord Compression, International Journal of Radiation Oncology*Biology*Physics. 2016, 96: E80-E81.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Ng S.C.Y., Kwong D.L.W., Lam K.O. and Leung T.W., Impact of intravenous contrast used in computed tomography on radiation dose to carotid arteries and thyroid in intensity-modulated radiation therapy planning for nasopharyngeal carcinoma., Medical Dosimetry. 2017, 42: 137-144.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Lam K.O., Tong C.C. and Lee W.M.A., Palliative systemic therapy for recurrent or metastatic nasopharyngeal carcinoma – How far have we achieved?, Critical Reviews in Oncology/Hematology. 2017, 114: 13-23.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee V.H.F., Lam K.O., Kwong D.L.W. and Leung T.W., Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report, Journal of Medical Case Reports. 2016, 10.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

Yeo W., Lam K.O., Law L.Y.A., Lee C.C.Y., Chiang C.L., Au K.H., Mo K.F., So T.H., Lam K.C., Ng W.T. and Li L., Adjuvant TS-1 chemotherapy after curative resection of gastric cancer in Chinese patients- Assessment of treatment tolerability and associated risk factors, Hong Kong Medical Journal. 2016.

Yeo W., Lam K.O., Law A.L., Chiang C.L., Lee C.C. and Au K.H., Author's reply: Adjuvant S-1 chemotherapy after curative resection of gastric cancer in Chinese patients: assessment of treatment tolerability and associated risk factors., Hong Kong Medical Journal. 2017, 23: 315-6.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Lam TC

Project Title:	A prospective cohort study on demoralization, quality of life and suicidal risk in advanced cancer patients
Investigator(s):	Lam TC, Lam WWT, Lee WMA, Kwong DLW, Lee VHF, Lam KO, So TH, Choi CW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2017

List of Research Outputs

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam T.C., Implications of High Precision RT, Targeted Therapies and Immunotherapies in Oncological Imaging, 24th Annual Scientific Meeting of Hong Kong College of Radiologists. 2016.

Lam T.C., Promoting Palliative Care Through Undergraduate Medical Education, The 9th Palliative Care Symposium for Health Care Workers in Chinese Population. 2016.

Lam T.C. and Lam P.L., The Impact of Integrated Palliative Care Service Model in Oncology: A Retrospective Study in a University-Hospital Network in Hong Kong, EAPC 2017. 15th World Congress of the European Association for Palliative Care. 2017.

Lam T.C., Lee W.M.A. and Li J.S., The Quality of End-of-Life Care amongst Advanced Cancer Patients in Mainland China – A Retrospective Cohort of 441 Patients in a New, Public- funded Hospital, EAPC 2017. 15th World Congress of the European Association for Palliative Care. 2017.

Lui F.C.W., Taw B.T.B., Lau E.C.H., Lee V.H.F., Lam T.C., Leung D.K.C., Leung G.K.K. and Lui W.M., Whole brain radiotherapy for more than 3 brain metastases: a single centre experience, The 23rd Annual Scientific Meeting of the Hong Kong Neurosurgical Society - Controversies in Neurosurgery, Hong Kong, 25-26 November 2016.

Sanders J.J., Chow V., Enzinger A.C., Lam T.C., Smith P.T., Quiñones R., Baccari A., Philbrick S., White-Hammond G., Peteet J., Balboni T.A. and Balboni M.J., Seeking and Accepting: U.S. Clergy Theological and Moral Perspectives Informing Decision Making at the End of Life, Journal of Palliative Medicine. 2017.

Researcher : Law LYA

List of Research Outputs

Yeo W., Lam K.O., Law L.Y.A., Lee C.C.Y., Chiang C.L., Au K.H., Mo K.F., So T.H., Lam K.C., Ng W.T. and Li L., Adjuvant TS-1 chemotherapy after curative resection of gastric cancer in Chinese patients- Assessment of treatment tolerability and associated risk factors, Hong Kong Medical Journal. 2016.

Researcher : Lee AWM

Project Title:	Prognostic and predictive biomarkers in loco-regionally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemotherapy: pooled analysis of data from the NPC-9901 and NPC-9902 trials
Investigator(s):	Lee WMA, Lam KO, Lee VHF, So TH, Kwong DLW, Guan X, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	AHNS 9th International Conference on Head and Neck Cancer; Instructional Course 1 - Nasopharynx Cancer Management 2016
Investigator(s):	Lee WMA
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Researcher : Lee CCY

List of Research Outputs

LEE F.A.S., ZEE B.C.Y., Cheung F.Y., Kwong W.K.P., Chiang C.L., LEUNG K.C., Siu W.K.S., Lee C.C.Y., LAI M., KWOK C., CHONG M., JOLIVET J. and TUNG S., Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC), American Journal of Clinical Oncology. 2016, 39: 609-613.

Yeo W., Lam K.O., Law L.Y.A., Lee C.C.Y., Chiang C.L., Au K.H., Mo K.F., So T.H., Lam K.C., Ng W.T. and Li L., Adjuvant TS-1 chemotherapy after curative resection of gastric cancer in Chinese patients- Assessment of treatment tolerability and associated risk factors, Hong Kong Medical Journal. 2016.

Researcher : Lee CH

List of Research Outputs

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Researcher : Lee VHF

Project Title:	Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):	Lee VHF, Kwong DLW, Lam KO
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2014

Project Title:	Granulocyte-colony stimulating factor (G-CSF) support to prevent neutropenia and its complications for patients receiving palliative chemotherapy for their stage IV metastatic cancer
Investigator(s):	Lee VHF, Kwong DLW, Lam KO
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2014

Project Title:	Development of Cancer Registry of Human Papilloma Virus (HPV)-associated Oral and Oropharyngeal Cancers in Hong Kong and its Correlation with Survival Outcomes
Investigator(s):	Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	ASTRO 56th Annual Meeting; Comparison of Post-treatment Plasma EBV DNA with Nasopharyngeal Biopsy in Patients After Radical (Chemo)Radiotherapy for Non-metastatic Nasopharyngeal Cancer
Investigator(s):	Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014

Project Title:	Magnetic resonance imaging (MRI) for monitoring treatment response in patients with inoperable hepatocellular carcinoma treated with transarterial chemoembolization (TACE) and/or radiotherapy
Investigator(s):	Lee VHF, Kwong DLW, Wong CS
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2015

Project Title:	FDG and 11C-acetate PET-CT scan to assess tumour response after stereotactic body radiation therapy as bridging therapy for patients with hepatocellular carcinoma awaiting liver transplantation
Investigator(s):	Lee VHF, Wong CLT, Vardhanabhuti V, Lam KO, Leung TW, Khong PL, Chan SC, Lo CM
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Role of individual dietary counselling on weight loss and change in quality of life in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy
Investigator(s):	Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Efficient Algorithms and Hardware Accelerators for Tensor Decomposition and Their Applications to Multidimensional Data Analysis
Investigator(s):	Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

CHAN A.T.C., Lee V.H.F., NGAN R., TO K.F., AHN M.J., NG Q.S., HONG R.L., LIN J.C., SWABY R.F., GAUSE C., SARAF S. and SPREAFICO A., 394TiP KEYNOTE-122: Phase 2 study of pembrolizumab versus standard-of-care chemotherapy in platinum-pretreated, recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Karam I., Yao M., Heron D.E., Poon I., Koyfman S.A., Yom S.S., Siddiqui F., Lartigau E., Cengiz M., Yamazaki H., Hara W., Phan J., Vargo J.A., Lee V.H.F., Foote R.L., Harter K.W., Lee N.Y., Sahgal A. and Lo S.S., Survey of current practices from the International Stereotactic Body Radiotherapy Consortium (ISBRTC) for head and neck cancers, Future Oncology. 2017, 13: 603-613.

Lam K.O., Lau J., Lam K., Yuen A., Kwok H., Tam F.K., Choi C.W., Lee V.H.F. and Leung T.W., A Comparison of Cetuximab with Oral versus Infusional Fluoropyrimidine in Chinese Patients in the Community Setting, The 24th Asia Pacific Cancer Conference in conjunction with the 43rd Annual Meeting of Korean Cancer Association. 2017.

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

Law M., Wong K.K., Tso W.K., Lee V.H.F., Luk M.Y., Tong C.C. and Chu F., Personnel dose reduction in 90Y microspheres liver-directed radioembolization: from interventional radiology suite to patient ward , The British Journal of Radiology. 2017, 90: 20160591.

Lee V.H.F., Associate Editor, Clinical Oncology (Royal College of Radiologists). 2017.

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Lee V.H.F., LAM T.W., NG S.C., SZETO M.H., Lam K.O. and Leung T.W., Effect of Titanium Hardware on Radiation Dosimetry in Postoperative Proton Versus Photon Spinal Stereotactic Body Radiation Therapy After Surgical Decompression for Spinal Cord Compression, International Journal of Radiation Oncology*Biology*Physics. 2016, 96: E80-E81.

Lee V.H.F., Lee W.M.A., Chang T.Y.A. and Ng W.T., Evidenced-Based Management of Nasopharyngeal Cancers in the Modern Era, Chemoradiotherapy: Concurrent Uses, Efficacy and Impact on Prognosis. 2017, 1-34.

Lee V.H.F., How far have we achieved by systemic therapy for recurrent/metastatic nasopharyngeal carcinoma?, Translational Cancer Research. 2016, 5: S1424-S1427.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Ng S.C.Y., Kwong D.L.W., Lam K.O. and Leung T.W., Impact of intravenous contrast used in computed tomography on radiation dose to carotid arteries and thyroid in intensity-modulated radiation therapy planning for nasopharyngeal carcinoma., Medical Dosimetry. 2017, 42: 137-144.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Nasopharyngeal Cancer: signs/ symptoms, investigation, Treatment & prevention. 2016.

Lee V.H.F., New Management Approach of EGFR TKI Resistance Progression, scientific symposium organized by Hong Kong Lung Cancer Study Group. 2016.

Lee V.H.F., Kwong D.L.W., Leung T.W., Lam K.O., Tong C.C. and Lee W.M.A., Palliative systemic therapy for recurrent or metastatic nasopharyngeal carcinoma – How far have we achieved?, Critical Reviews in Oncology/Hematology. 2017, 114: 13-23.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee V.H.F., Lam K.O., Kwong D.L.W. and Leung T.W., Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report, Journal of Medical Case Reports. 2016, 10.

Lee V.H.F., The aftermath of LUX-Lung 7 study—what have we learnt from it?, Annals of Translational Medicine. 2016, 4: 294-294.

Lee W.M.A., Tung S.Y., Ng W.T., Lee V.H.F., Ngan R.K.C., Choi C.W., Chan L.L.K., Siu L.L., Ng A.W.Y., Leung T.W., Yiu H.H.Y., O'Sullivan B. and Chappell R., A multicenter, phase 3, randomized trial of concurrent chemoradiotherapy plus adjuvant chemotherapy versus radiotherapy alone in patients with regionally advanced nasopharyngeal carcinoma: 10-year outcomes for efficacy and toxicity, Cancer. 2017.

Lui F.C.W., Taw B.T.B., Lau E.C.H., Lee V.H.F., Lam T.C., Leung D.K.C., Leung G.K.K. and Lui W.M., Whole brain radiotherapy for more than 3 brain metastases: a single centre experience, The 23rd Annual Scientific Meeting of the Hong Kong Neurosurgical Society - Controversies in Neurosurgery, Hong Kong, 25-26 November 2016.

Pang H.M.H., Stinchcombe T., Cheng K.M.P., Lee W.M.A., Lee V.H.F., Vokes E.E. and Wang X., Comparison of chemoradiotherapy treatment strategies in stage III non-small cell lung cancer among elderly patients from multiple data sources, Annals of Oncology. 2017, 28.

SEOW W.J., Matsuo K.C., HUISUNG C.A., Shiraishi K., SONG M.S., KIM H.N., WONG M.P., HONG Y.C., Hosgood H.D., WANG Z.M., CHANG I.S., WANG J.C., Chatterjee N., TUCKER M., WEI H., Mitsudomi T., ZHENG W., KIM J.H., ZHOU B.S., CAPORASO N.E., ALBANES D., SHIN M.H., CHUNG L.P., AN S.J., WANG P., Zheng H., Yatabe Y., ZHANG X.C., KIM Y.T., SHU X.Q., KIM Y.C., BASSIG B.A., CHANG J., HO J.C.M., JU B.T., KUBO M., DAIGO Y., ITO Y., Momozawa Y., Ashikawa K., KamatanI Y., Honda T., Sakamoto H., Kunitoh H., TSUTA K., Watanabe S.I., Nokihara H., Miyagi Y., Nakayama H., Matsumoto S., Tsuboi M., GOTO K., YIN Z.H., SHI J.X., Takahashi A., GOTO A., Minamiya Y., Shimizu K., Tanaka K., WU T.C., WEI F.S., WONG J.Y.Y., Matsuda F., SU J., KIM Y.H., OH I.J., SONG F.J., Lee V.H.F., SU W.C., CHEN Y.M., CHANG G.C., CHEN K.Y., HUANG M.S., YANG P.C., LIN H.C., XIANG Y.B., SEOW A., PARK J.Y., KWEON S.S., CHEN C.J., LI H.X., GAO Y.T., WU C., QIAN B.Y., LU D., LIU J.J., JEON H.S., HSIAO C.F., SUNG J.S., TSAI Y.H., JUNG Y.J., GUO H., HU Z.B., WANG W.C., CHUNG C.C., LAWRENCE C., BURDETT L., YEAGER M., JACOBS K.B., Hutchinson A., Berndt S.L., HE X.Z., WU W., WANG J.W., LI Y.Q., CHOI J.E., PARK K.H., SUNG S.W., LIU L.I., KANG C.H., HU L.M., CHEN C.H., YANG T.Y., XU J., GUAN P., TAN W., WANG C.L., SIHOE A.D.L., CHEN Y., CHOI Y.Y., HUNG J.Y., KIM J.S., YOON H.L., CAI Q.Y., LIN C.C., PARK I.K., XU P., DONG J., KIM C., HE Q.C., PENG R.P., CHEN C.Y., Vermeulen R., WU J.J., LIM W.Y., CHEN K.C., CHAN J.K.C., CHU M.J., LI Y.J., LI J.H., CHEN H.Y., YU C.J., JIN L., LO Y.L., CHEN Y.H., Fraumeni J.F., LIU J., Yamaji T., YANG Y., HICKS B., WYATT K., LI S.A., DAI J.C., MA H.X., JIN G.F., SONG B., WANG Z.H., CHENG S.S., LI X.L., REN Y.W., CUI P., Iwasaki M., Shimazu T., Tsugane S., ZHU J.J., Jiang G.N., FEI K., WU G.P., CHIEN L.H., CHEN H.L., SU Y.C., TSAI F.Y., CHEN Y.S., YU J.M., Stevens V.L., Laird-Offringa L.A., Marconett C.N., LIN D.X., CHEN K., WU Y.L., LANDI M.T., SHEN H.B., Rothman N., Kohno T., CHanock S.J. and Lan Q., Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations , Human Molecular Genetics. 2016, ddw414.

SIU L.L., Lee V.H.F., NGAN R., TO K.F., AHN M.J., NG Q.S., HONG R.L., LIN J.C., SWABY R.F., CHENG J., SARAF S. and CHAN A.T., Pembrolizumab (MK-3475) vs Standard of Care Chemotherapy in Platinum Pretreated, Recurrent or Metastatic Nasopharyngeal Cancer: the Phase 2 KEYNOTE-122 Study, American Head and Neck Society 9th International Conference of Head and Neck Cancer. Seattle, USA, 2016.

Smith C., Lee V.H.F., Schuessler A., Beagley L., Rehan S., Tsang W.H.J., Li V., Tiu R., Smith D., Neller M., Matthews K.K., Gostick E., Price D.A., Burrows J., Boyle G.M., Chua D., Panizza B., Porceddu S.V., Nicholls J., Kwong D.L.W. and Khanna R., Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response, OncoImmunology. 2017, 1-9.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

ZHANG N., Fielding R., Soong S.I., Chan K.K.L., Lee C., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Psychometric assessment of the Chinese version of the brief illness perception questionnaire in breast cancer survivors, PLoS One. 2017, 12(3): e0174093.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Lee WMA

Project Title:	Prognostic and predictive biomarkers in loco-regionally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemotherapy: pooled analysis of data from the NPC-9901 and NPC-9902 trials
Investigator(s):	Lee WMA, Lam KO, Lee VHF, So TH, Kwong DLW, Guan X, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	AHNS 9th International Conference on Head and Neck Cancer; Instructional Course 1 - Nasopharynx Cancer Management 2016
Investigator(s):	Lee WMA
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Choi C.W., Xu W. and Lee W.M.A., Reply to Nomograms need to be presented in full, Cancer. 2017, 123: 178-179.

Lam T.C., Lee W.M.A. and Li J.S., The Quality of End-of-Life Care amongst Advanced Cancer Patients in Mainland China – A Retrospective Cohort of 441 Patients in a New, Public- funded Hospital, EAPC 2017. 15th World Congress of the European Association for Palliative Care. 2017.

Lee V.H.F., Lee W.M.A., Chang T.Y.A. and Ng W.T., Evidenced-Based Management of Nasopharyngeal Cancers in the Modern Era, Chemoradiotherapy: Concurrent Uses, Efficacy and Impact on Prognosis. 2017, 1-34.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Lam K.O., Tong C.C. and Lee W.M.A., Palliative systemic therapy for recurrent or metastatic nasopharyngeal carcinoma – How far have we achieved?, Critical Reviews in Oncology/Hematology. 2017, 114: 13-23.

Lee W.M.A., Tung S.Y., Ng W.T., Lee V.H.F., Ngan R.K.C., Choi C.W., Chan L.L.K., Siu L.L., Ng A.W.Y., Leung T.W., Yiu H.H.Y., O'Sullivan B. and Chappell R., A multicenter, phase 3, randomized trial of concurrent chemoradiotherapy plus adjuvant chemotherapy versus radiotherapy alone in patients with regionally advanced nasopharyngeal carcinoma: 10-year outcomes for efficacy and toxicity, Cancer. 2017.

Lee W.M.A., Cancer classifications guiding patient care - China and GAG perspective on staging, World Cancer Congress. 2016.

Lee W.M.A., Instructional Courses 1 - Nasopharynx Cancer Management 2016, The AHNS International Conference on Head and Neck Cancer, Seattle, USA. 2016.

Lee W.M.A., Management of Nasopharyngeal Cancer - Evolving Technologies, The 13th National Conference on Radiation Oncology of CSTRO. 2016.

Lee W.M.A., Ng W.T., Ngan K.C., Chan O.S.H., Sze C.K.H. and Chan J.Y.W., Management of nasopharyngeal carcinoma, In: J. Bernier, Head and Neck Cancer: Multimodality Management. 2nd edition. Springer, 2016, 445-473.

Lee W.M.A., NPC in Hong Kong over previous 60 years, 3rd Hong Kong International Oncology Symposium 2016. 2016.

Lee W.M.A., Nasopharyngeal Cancer: Current Management and Beyond - Overall Treatment Strategy & Radiation Therapy. , The AHNS International Conference on Head and Neck Cancer, Seattle, USA. 2016.

Lee W.M.A., Nasopharyngeal Carcinoma, Gordon Research Conference. 2016.

Lee W.M.A., The Fight against Cancer in Hong Kong & our Contribution to the Asia-Pacific Region, World Cancer Congress. 2016.

Lee W.M.A., 抗癌三部曲：战胜肿瘤不是梦, 健康深圳大讲堂. 2016.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

Ng W.T., Ngan R.K.C., Lee W.M.A., Kwong D.L.W., Tung S.Y., Yuen K.T., Kam M.K., Chan L.U.C.Y. and Lung M.L., Phase II multicenter trial evaluating the role of induction TPF followed by weekly docetaxel and cetuximab in combination with IMRT for locally recurrent nasopharyngeal carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.. 2017.

Pan J.J., Ng W.T., Zong J.F., Lee S.W., Choi C.W., Chan L.L., Lin S.J., Guo Q.J., Sze H.C., Chen Y.B., Xiao Y.P., Kan W.K., O'Sullivan B., Xu W., Le Q.T., Glastonbury C.M., Colevas A.D., Weber R.S., Lydiatt W., Shan J.P. and Lee W.M.A., Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy, In: American Cancer Society, Cancer. 2016.

Pang H.M.H., Stinchcombe T., Cheng K.M.P., Lee W.M.A., Lee V.H.F., Vokes E.E. and Wang X., Comparison of chemoradiotherapy treatment strategies in stage III non-small cell lung cancer among elderly patients from multiple data sources, Annals of Oncology. 2017, 28.

Ribassin-Majed L., Marguet S., Lee W.M.A., Ng W.T., Ma J., Chan A.T., Huang P.Y., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L.W., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzilas G., Bourhis J., Pigeon J.P. and Blanchard P., What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis, Journal of Clinical Oncology. 2017, 35: 498-505.

Rotolo F., Pignon J.P., Bourhis J., Marguet S., Lee W.M.A., Ma J., Chan A.T.C., Huang P.Y., Kwong D.L.W. and Chau D.T.T., Surrogate End Points for Overall Survival in Loco-Regionally Advanced Nasopharyngeal Carcinoma: An Individual Patient DataMeta-analysis, Journal of the National Cancer Institute. Journal of the National Cancer Institute, 2017, JNCI J Natl Cancer Inst (2017) 109(4): djw239.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Leung TW

List of Research Outputs

LAU K.S., Lam K.O., CHOY T.S. and Leung T.W., Discordant RAS status between primary and metastatic colorectal cancer: pattern of metastasis and sidedness of primary tumor, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lee V.H.F., LAM T.W., NG S.C., SZETO M.H., Lam K.O. and Leung T.W., Effect of Titanium Hardware on Radiation Dosimetry in Postoperative Proton Versus Photon Spinal Stereotactic Body Radiation Therapy After Surgical Decompression for Spinal Cord Compression, International Journal of Radiation Oncology*Biology*Physics. 2016, 96: E80-E81.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Kwong D.L.W., Lai Y.C., Li Y., Lam K.O., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K., Chan S.Y., Chan F.T., Lau K.S., Tse R.P., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as 3rd line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Annals of Oncology. 2016, 27.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee V.H.F., Lam K.O., Kwong D.L.W. and Leung T.W., Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report, Journal of Medical Case Reports. 2016, 10.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

Researcher : Li Y

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Jiang L., Liu M., Li Y., Kwong D.L.W. and Guan X., Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway, 钙结合蛋白39通过ERK信号通路促进肝癌细胞的转移, In: David E. Cohen, Hepatology. 2017.

Li L., Zhu Y.H., Li Y. and Guan X., Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma, Neoplasma. 2017.

Tian B.Q., Chen X.J., Zhang H.H., Li X.Y., Wang J.K., Han W., Zhang L., Fu L., Li Y., Nie C.J., Zhao Y., Tan X., Wang H.L., Guan X. and Hong A., Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma, Oncotarget. 2017.

Researcher : Li YM

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Researcher : Liu M

Project Title:	2016 the Japanese Society of Medical Oncology Annual Meeting; CHD1L promotes poor differentiation and liver ancestral precursor cell properties of human hepatocellular carcinoma
Investigator(s):	Liu M
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Fang S., Li L., Liu M. and Guan X., LEF1 negatively regulates differentiation of hepatocellular carcinoma via activation of NOTCH signaling pathway, AACR 108th Annul Meeting; April 2017, San Diego, USA. 2017.

Jiang L., Liu M., Li Y., Kwong D.L.W. and Guan X., Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway, 钙结合蛋白39通过ERK信号通路促进肝癌细胞的转移, In: David E. Cohen, Hepatology. 2017.

Researcher : Luk MY

List of Research Outputs

Law M., Wong K.K., Tso W.K., Lee V.H.F., Luk M.Y., Tong C.C. and Chu F., Personnel dose reduction in 90Y microspheres liver-directed radioembolization: from interventional radiology suite to patient ward , The British Journal of Radiology. 2017, 90: 20160591.

Researcher : Lung HL

Project Title:	The serum amyloid A1 (SAA1) Polymorphisms as Risk Factors in Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung HL, Lung ML, Law SYK
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	The effects of the IKKbeta-specific inhibitor PS1145 on tumor formation and metastasis in nasopharyngeal carcinoma
Investigator(s):	Lung HL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

List of Research Outputs

Lung H.L., Chau W.Y., Lee N.P.Y., Law S.Y.K. and Lung M.L., Early detection and prognosis of esophageal squamous cell carcinoma (ESCC) using the circulating plasma SAA protein and the SAA1 polymorphisms (Abstract), Health Research Symposium 2017, Hong Kong, 16 June 2017.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Lung ML

Project Title:	Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2009

Project Title:	Centre for Nasopharyngeal Carcinoma Research
Investigator(s):	Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:	Clinical Oncology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2010

Project Title:	Elucidating the functional role of a metastasis-associated extracellular matrix gene, ECM1, in esophageal cancer
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	10/2016

Project Title:	Advances in Nasopharyngeal Carcinoma Studies
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	11/2014

Project Title:	Secretory NID2, a basement membrane protein facilitating cell adhesion, migration, and metastasis in human cancers
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Regulation and Clinical Implication of PD-L1 Expression in Esophageal Tumor Cells subjected to Chemotherapy
Investigator(s):	Lung ML, Ko JMY, Yu Z
Department:	Clinical Oncology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	11/2015

Project Title:	Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung ML, Chan KW, Law SYK, Song Y
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Functional studies of Pol K and Pol Q mutations detected at high frequency in high-risk esophageal carcinoma patients
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	AACR/AHNS: Head and Neck Cancer Conference; Elucidation of genetic susceptibility genes using next-generation sequencing (NGS) approach in nasopharyngeal carcinoma
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Establishing platform technology for use of circulating tumor cells for cancer diagnostics and drug testing
Investigator(s):	Lung ML, Ko JMY, Dai W
Department:	Clinical Oncology
Source(s) of Funding:	Platform Technology Funding
Start Date:	06/2017

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional Analysis of a Basement Membrane Protein, Nidogen-2 (NID2), in Nasopharyngeal Carcinoma and Esophageal Squamous Cell Carcinoma, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y. and Lung M.L., Functional analysis of a basement membrane protein, Nidogen-2 (NID2) in NPC and ESCC, Sydney Cancer Conference, Australia, September 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Lung H.L., Chau W.Y., Lee N.P.Y., Law S.Y.K. and Lung M.L., Early detection and prognosis of esophageal squamous cell carcinoma (ESCC) using the circulating plasma SAA protein and the SAA1 polymorphisms (Abstract), Health Research Symposium 2017, Hong Kong, 16 June 2017.

Lung M.L., "Centre for Nasopharyngeal Carcinoma Research" HK$707,783, FIL Foundation. 2017.

Lung M.L., "Establishing platform technology for use of circulating tumor cells for cancer diagnostics & drug testing" HK$1,000,000, Platform Technology Funding. 2017.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

Lung M.L., Minisymposium on Nasopharyngeal Carcinoma- epidemiology, genetics, EBV and pathobiology, Genomic landscape of nasopharyngeal carcinoma. Karolinska Institute, Stockholm, Sweden. May 30, 2017.. 2017.

Lung M.L., Whole-exome Sequencing-identified Macrophage-stimulating Receptor 1 (MST1R) in NPC Genetic Susceptibility. Hong Kong International Oncology Forum, Hong Kong. May 19-20, 2017. Plenary speaker.. 2017.

NING L., Ko J.M.Y. and Lung M.L., Genetic Susceptibility of Familial Esophagus Squamous Cell Carcinomas (ESCC) by Target Sequencing for Germline Rare Deleterious Variants, 24th Asia Pacific Cancer Conference (APCC 2017), Seoul, Korea. June 22-24, 2017.. 2017.

Ng W.T., Ngan R.K.C., Lee W.M.A., Kwong D.L.W., Tung S.Y., Yuen K.T., Kam M.K., Chan L.U.C.Y. and Lung M.L., Phase II multicenter trial evaluating the role of induction TPF followed by weekly docetaxel and cetuximab in combination with IMRT for locally recurrent nasopharyngeal carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

Wong V.C., Ko J.M.Y., Lam C.T. and Lung M.L., Succinct workflows for circulating tumor cells after enrichment: from systematic counting to mutational profiling. , PLOS One. 2017, 12.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Ma SKY

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):	Ma SKY, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	10/2016

Project Title:	Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):	Ma SKY, Chan KW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	11/2016

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2015

Project Title:	PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):	Ma SKY, Guan X, Lo CM, Man K
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	09/2017

Project Title:	Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	05/2016
Completion Date:	04/2017

Project Title:	Role of PRMT6 in regulating cancer and stemness properties in hepatocellular carcinoma
Investigator(s):	Ma SKY, Leung SY, Yan HHN
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	AACR Annual Meeting; Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Role of MAPK11 in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications (CRF)
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

List of Research Outputs

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Researcher : Ming X

List of Research Outputs

Cao T., Lin S.H., Fu L., Tang Z., Che C.M., Zhang L., Ming X., Liu T.F., Tang X.M., Tan B.B., Xiang D., Li F., Chan O.Y., Xie D., Cai Z. and Guan X., Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells, Carcinogenesis. 2017, 38: 94-104.

Fu L., Qin Y.R., Ming X., Zuo X.B., Diao Y.W., Zhang L., Ai J., Liu B.L., Huang T.X., Cao T., Tan B.B., Xiang D., Zeng C.M., Gong J., Zhang Q., Dong S., Chen J., Liu H., Wu J.L., Qi R.Z., Xie D., Wang L.D. and Guan X., RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer, Pro Nat Aca Sci USA. 2017, 114: E4631-4640.

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Researcher : NING L

List of Research Outputs

NING L., Ko J.M.Y. and Lung M.L., Genetic Susceptibility of Familial Esophagus Squamous Cell Carcinomas (ESCC) by Target Sequencing for Germline Rare Deleterious Variants, 24th Asia Pacific Cancer Conference (APCC 2017), Seoul, Korea. June 22-24, 2017.. 2017.

Researcher : Ng CY

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Researcher : Ng SH

List of Research Outputs

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Researcher : Ng WT

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Lee V.H.F., Lee W.M.A., Chang T.Y.A. and Ng W.T., Evidenced-Based Management of Nasopharyngeal Cancers in the Modern Era, Chemoradiotherapy: Concurrent Uses, Efficacy and Impact on Prognosis. 2017, 1-34.

Lee W.M.A., Ng W.T., Ngan K.C., Chan O.S.H., Sze C.K.H. and Chan J.Y.W., Management of nasopharyngeal carcinoma, In: J. Bernier, Head and Neck Cancer: Multimodality Management. 2nd edition. Springer, 2016, 445-473.

Yeo W., Lam K.O., Law L.Y.A., Lee C.C.Y., Chiang C.L., Au K.H., Mo K.F., So T.H., Lam K.C., Ng W.T. and Li L., Adjuvant TS-1 chemotherapy after curative resection of gastric cancer in Chinese patients- Assessment of treatment tolerability and associated risk factors, Hong Kong Medical Journal. 2016.

Researcher : Ngan KC

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Hui T.H.K., Tang Y.H., YAN Z., Yip T.C., Fong H.W., Cho W.C., Ngan K.C., Shum H.C. and Lin Y., Cadherin- and Rigidity-Dependent Growth of Lung Cancer Cells in a Partially Confined Microenvironment, ACS Biomaterials Science & Engineering. 2017.

Lee W.M.A., Ng W.T., Ngan K.C., Chan O.S.H., Sze C.K.H. and Chan J.Y.W., Management of nasopharyngeal carcinoma, In: J. Bernier, Head and Neck Cancer: Multimodality Management. 2nd edition. Springer, 2016, 445-473.

Researcher : SONG Y

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Researcher : Shi C

List of Research Outputs

Jiang L., YAN Q., WANG X., Shi C. and Guan X., Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model, 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia. 2017.

WANG X., Jiang L., Shi C., Chen H. and Guan X., Characterization of a stemness-related gene RALYL in the development and progression of hepatocellular carcinoma, 3rd EACR Conference on Cancer Genomics; June 25-28, 2017, Cambridge, UK. 2017.

Researcher : Siu WKS

List of Research Outputs

LEE F.A.S., ZEE B.C.Y., Cheung F.Y., Kwong W.K.P., Chiang C.L., LEUNG K.C., Siu W.K.S., Lee C.C.Y., LAI M., KWOK C., CHONG M., JOLIVET J. and TUNG S., Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC), American Journal of Clinical Oncology. 2016, 39: 609-613.

Lee E.Y.P., PERUCHO J.A.U., Vardhanabhuti V., He J., Siu W.K.S., Ngu S.F., Mayr N.A., Yuh W.T.C., Chan Q. and Khong P.L., Intravoxel incoherent motion MRI assessment of chemoradiation-induced pelvic bone marrow changes in cervical cancer and correlation with hematological toxicity, Journal of Magnetic Resonance Imaging. 2017.

Researcher : So TH

List of Research Outputs

Lam K.O., Lo A.W.I., Wong H., Choi C.W., CHOY T.S., Lee V.H.F., Lam T.C., So T.H., Fu C.C., Shek W.H. and Leung T.W., A prospective study on the predictive and prognostic value of baseline biomarker expressions in locoregionally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine, The 24th Annual Scientific Meeting. Hong Kong College of Radiologists, Hong Kong. 2016.

Lam K.O., Lo A.W.I., Choi C.W., HO I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-006PD-L1 hotspot in tumor-infiltrating lymphocytes of radically treated esophageal squamous cell carcinoma: Pattern of recurrence and long-term clinical outcomes, 19th World Congress of Gastrointestinal Cancer (29-Jun-2017), Barcelona, Spain . 2017, 28.

Lam K.O., Lo A.W.I., Choi C.W., Ho I., Law B.T.T., Chan W.L., Lee V.H.F., So T.H., Chiang C.L., Chan S.Y., Tong D.K.H., Kwong D.L.W. and Law S.Y.K., PD-L1 Hotspot in Tumor-Infiltrating Lymphocytes of Radically Treated Esophageal Squamous Cell Carcinoma: Pattern of recurrence and long-term clinical outcomes, The ESMO 19h World Congress on Gastrointestinal Cancer. 2017.

So T.H., Lam K.O., Kwong D.L.W., Law S.Y.K., Leung T.W., Choi C.W., Chan W.L.W., Chan S.Y., Lee V.H.F. and Law T.T., Lymphopenia Association with Planning Target Volume and Lung V5 and its effect on survival of esophageal cancer receiving neoadjuvant chemo-radiation with Dutch CROSS regime, 19th World Congress on Gastrointestinal Cancer 2017.

Yeo W., Lam K.O., Law L.Y.A., Lee C.C.Y., Chiang C.L., Au K.H., Mo K.F., So T.H., Lam K.C., Ng W.T. and Li L., Adjuvant TS-1 chemotherapy after curative resection of gastric cancer in Chinese patients- Assessment of treatment tolerability and associated risk factors, Hong Kong Medical Journal. 2016.

Researcher : Soong SI

List of Research Outputs

ZHANG N., Fielding R., Soong S.I., Chan K.K.L., Lee C., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Psychometric assessment of the Chinese version of the brief illness perception questionnaire in breast cancer survivors, PLoS One. 2017, 12(3): e0174093.

Researcher : Sze CKH

List of Research Outputs

Chan O.S.H., Sze C.K.H., Lee C.H., Chan L.L.K., Chang T.Y.A., Lee S.W.M., Hung W.M., Lee W.M.A. and Ng W.T., Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma, Head & Neck. 2016.

Choi K.K., Lee A.S., Chiang C.L., Wong F.C.S., Sze C.K.H. and Tung S.Y., The Efficacy, Toxicities and Prognostic Factors of Stereotactic Radiotherapy in Locally Advanced Unresectable Hepatitis B Related Hepatocellular Carcinoma, 7th Asia-Pacific Primary Liver Cancer Expert Meeting, 9 July 2016, Hong Kong. 2016.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Lee W.M.A., Ng W.T., Ngan K.C., Chan O.S.H., Sze C.K.H. and Chan J.Y.W., Management of nasopharyngeal carcinoma, In: J. Bernier, Head and Neck Cancer: Multimodality Management. 2nd edition. Springer, 2016, 445-473.

Researcher : Szeto HMM

List of Research Outputs

Lee V.H.F., Wong V.C.L., Lam C.T., Ho P.Y.P., Szeto H.M.M., Ng S.H., Ko J.M.Y. and Lung M.L., Correlation of circulating tumor cells with response to SBRT for inoperable hepatocellular carcinoma, ASCO, Chicago, IL, USA. June 2-6, 2017.

Researcher : Tang H

List of Research Outputs

Tang H., Wu Y., Qin Y., Wang H., Wang L., Guan X., Luo S. and Wang Q., Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in northern China, Onco Targets Ther. 2016, 10: 85-94.

Researcher : Tong CC

List of Research Outputs

Law M., Wong K.K., Tso W.K., Lee V.H.F., Luk M.Y., Tong C.C. and Chu F., Personnel dose reduction in 90Y microspheres liver-directed radioembolization: from interventional radiology suite to patient ward , The British Journal of Radiology. 2017, 90: 20160591.

Lee V.H.F., Kwong D.L.W., Leung T.W., Ng C.Y., Lam K.O., Tong C.C. and Sze C.K.H., Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma, European Archives of Oto-Rhino-Laryngology. 2017, 274: 1067-1078.

Lee V.H.F., Kwong D.L.W., Lam K.O., Lai Y.C., Li Y.M., Tong C.C., Ho P.Y.P., Chan W.L.W., WONG L.S., LEUNG D.K.S., CHAN S.Y., CHAN F.T., Leung T.W. and Lee W.M.A., Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma, Medicine. 2017, 96: e6518.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., Lai V., Ng C.Y., Sze C.K.H., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Kwok C.L.D., Chan S.Y., Khong P.L., Lam K.O. and Ng L., Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma, Oncotarget. 2017, 5292-5308.

Researcher : Tsang JWH

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang WHJ, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):	Tsang WHJ, Khoo US
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

List of Research Outputs

Researcher : Tsang WHJ

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang WHJ, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):	Tsang WHJ, Khoo US
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

List of Research Outputs

Fielding R., Lam W.W.T., Liao Q., Lai C.L., Tsang W.H.J., Ip D.K.M. and Yuen R.M.F., Perceptions of cancer risk and self-care practices: comparison of groups at different risk for cancers, Hong Kong Medical Journal. 2016, 22 Suppl 6(6): 8-12.

Smith C., Lee V.H.F., Schuessler A., Beagley L., Rehan S., Tsang W.H.J., Li V., Tiu R., Smith D., Neller M., Matthews K.K., Gostick E., Price D.A., Burrows J., Boyle G.M., Chua D., Panizza B., Porceddu S.V., Nicholls J., Kwong D.L.W. and Khanna R., Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response, OncoImmunology. 2017, 1-9.

ZHANG N., Fielding R., Soong S.I., Chan K.K.L., Lee C., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Psychometric assessment of the Chinese version of the brief illness perception questionnaire in breast cancer survivors, PLoS One. 2017, 12(3): e0174093.

Researcher : Wong WY

List of Research Outputs

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : XIAN Z

List of Research Outputs

Chow K.K.R., XIAN Z., Liu M., Li Y., CHAN H.M., SONG Y., Chen L.L., Kwong D.L.W. and Guan X., AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways, Oncotarget. 2016.

Researcher : YAN Q

List of Research Outputs

Jiang L., YAN Q., WANG X., Shi C. and Guan X., Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model, 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia. 2017.

Researcher : Yau CC

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Researcher : Yu Z

Project Title:	Functional and mechanistic analysis of PHF11 in esophageal squamous cell carcinoma epigenetics
Investigator(s):	Yu Z, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Researcher : ZHENG H

List of Research Outputs

DENG M., Lung M.L., Cheung A.K.L., Dai W., Chan K.C. and ZHENG H., Functional and Molecular Analysis of the Loss-of-Function Somatic Mutations in Two NF-KB Pathway Inhibitors, 24th Asia Pacific Cancer Conference, Coex, Seoul, Korea. June 22-24, 2017.. 2017.

Dai W., Tang C., ZHENG H., Cheung A.K.L., Ko J.M.Y., Wong W.Y., Sham P.C. and Lung M.L., Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma, 17th International Symposium on EBV and Associated Diseases. Zurich, Switzerland. Aug 8-12, 2016.

Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017.

SEOW W.J., Matsuo K.C., HUISUNG C.A., Shiraishi K., SONG M.S., KIM H.N., WONG M.P., HONG Y.C., Hosgood H.D., WANG Z.M., CHANG I.S., WANG J.C., Chatterjee N., TUCKER M., WEI H., Mitsudomi T., ZHENG W., KIM J.H., ZHOU B.S., CAPORASO N.E., ALBANES D., SHIN M.H., CHUNG L.P., AN S.J., WANG P., Zheng H., Yatabe Y., ZHANG X.C., KIM Y.T., SHU X.Q., KIM Y.C., BASSIG B.A., CHANG J., HO J.C.M., JU B.T., KUBO M., DAIGO Y., ITO Y., Momozawa Y., Ashikawa K., KamatanI Y., Honda T., Sakamoto H., Kunitoh H., TSUTA K., Watanabe S.I., Nokihara H., Miyagi Y., Nakayama H., Matsumoto S., Tsuboi M., GOTO K., YIN Z.H., SHI J.X., Takahashi A., GOTO A., Minamiya Y., Shimizu K., Tanaka K., WU T.C., WEI F.S., WONG J.Y.Y., Matsuda F., SU J., KIM Y.H., OH I.J., SONG F.J., Lee V.H.F., SU W.C., CHEN Y.M., CHANG G.C., CHEN K.Y., HUANG M.S., YANG P.C., LIN H.C., XIANG Y.B., SEOW A., PARK J.Y., KWEON S.S., CHEN C.J., LI H.X., GAO Y.T., WU C., QIAN B.Y., LU D., LIU J.J., JEON H.S., HSIAO C.F., SUNG J.S., TSAI Y.H., JUNG Y.J., GUO H., HU Z.B., WANG W.C., CHUNG C.C., LAWRENCE C., BURDETT L., YEAGER M., JACOBS K.B., Hutchinson A., Berndt S.L., HE X.Z., WU W., WANG J.W., LI Y.Q., CHOI J.E., PARK K.H., SUNG S.W., LIU L.I., KANG C.H., HU L.M., CHEN C.H., YANG T.Y., XU J., GUAN P., TAN W., WANG C.L., SIHOE A.D.L., CHEN Y., CHOI Y.Y., HUNG J.Y., KIM J.S., YOON H.L., CAI Q.Y., LIN C.C., PARK I.K., XU P., DONG J., KIM C., HE Q.C., PENG R.P., CHEN C.Y., Vermeulen R., WU J.J., LIM W.Y., CHEN K.C., CHAN J.K.C., CHU M.J., LI Y.J., LI J.H., CHEN H.Y., YU C.J., JIN L., LO Y.L., CHEN Y.H., Fraumeni J.F., LIU J., Yamaji T., YANG Y., HICKS B., WYATT K., LI S.A., DAI J.C., MA H.X., JIN G.F., SONG B., WANG Z.H., CHENG S.S., LI X.L., REN Y.W., CUI P., Iwasaki M., Shimazu T., Tsugane S., ZHU J.J., Jiang G.N., FEI K., WU G.P., CHIEN L.H., CHEN H.L., SU Y.C., TSAI F.Y., CHEN Y.S., YU J.M., Stevens V.L., Laird-Offringa L.A., Marconett C.N., LIN D.X., CHEN K., WU Y.L., LANDI M.T., SHEN H.B., Rothman N., Kohno T., CHanock S.J. and Lan Q., Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations , Human Molecular Genetics. 2016, ddw414.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Zhang L

List of Research Outputs

Cao T., Lin S.H., Fu L., Tang Z., Che C.M., Zhang L., Ming X., Liu T.F., Tang X.M., Tan B.B., Xiang D., Li F., Chan O.Y., Xie D., Cai Z. and Guan X., Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells, Carcinogenesis. 2017, 38: 94-104.

Fu L., Qin Y.R., Ming X., Zuo X.B., Diao Y.W., Zhang L., Ai J., Liu B.L., Huang T.X., Cao T., Tan B.B., Xiang D., Zeng C.M., Gong J., Zhang Q., Dong S., Chen J., Liu H., Wu J.L., Qi R.Z., Xie D., Wang L.D. and Guan X., RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer, Pro Nat Aca Sci USA. 2017, 114: E4631-4640.

Ming X., Fu L., Zhang L., Qin Y., Cao T., Chan K.W., Ma S.K.Y., Xie D. and Guan X., Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma, Nature Communications. 2016, 7: 13568.

Tian B.Q., Chen X.J., Zhang H.H., Li X.Y., Wang J.K., Han W., Zhang L., Fu L., Li Y., Nie C.J., Zhao Y., Tan X., Wang H.L., Guan X. and Hong A., Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma, Oncotarget. 2017.

Researcher : Zheng H

List of Research Outputs

SEOW W.J., Matsuo K.C., HUISUNG C.A., Shiraishi K., SONG M.S., KIM H.N., WONG M.P., HONG Y.C., Hosgood H.D., WANG Z.M., CHANG I.S., WANG J.C., Chatterjee N., TUCKER M., WEI H., Mitsudomi T., ZHENG W., KIM J.H., ZHOU B.S., CAPORASO N.E., ALBANES D., SHIN M.H., CHUNG L.P., AN S.J., WANG P., Zheng H., Yatabe Y., ZHANG X.C., KIM Y.T., SHU X.Q., KIM Y.C., BASSIG B.A., CHANG J., HO J.C.M., JU B.T., KUBO M., DAIGO Y., ITO Y., Momozawa Y., Ashikawa K., KamatanI Y., Honda T., Sakamoto H., Kunitoh H., TSUTA K., Watanabe S.I., Nokihara H., Miyagi Y., Nakayama H., Matsumoto S., Tsuboi M., GOTO K., YIN Z.H., SHI J.X., Takahashi A., GOTO A., Minamiya Y., Shimizu K., Tanaka K., WU T.C., WEI F.S., WONG J.Y.Y., Matsuda F., SU J., KIM Y.H., OH I.J., SONG F.J., Lee V.H.F., SU W.C., CHEN Y.M., CHANG G.C., CHEN K.Y., HUANG M.S., YANG P.C., LIN H.C., XIANG Y.B., SEOW A., PARK J.Y., KWEON S.S., CHEN C.J., LI H.X., GAO Y.T., WU C., QIAN B.Y., LU D., LIU J.J., JEON H.S., HSIAO C.F., SUNG J.S., TSAI Y.H., JUNG Y.J., GUO H., HU Z.B., WANG W.C., CHUNG C.C., LAWRENCE C., BURDETT L., YEAGER M., JACOBS K.B., Hutchinson A., Berndt S.L., HE X.Z., WU W., WANG J.W., LI Y.Q., CHOI J.E., PARK K.H., SUNG S.W., LIU L.I., KANG C.H., HU L.M., CHEN C.H., YANG T.Y., XU J., GUAN P., TAN W., WANG C.L., SIHOE A.D.L., CHEN Y., CHOI Y.Y., HUNG J.Y., KIM J.S., YOON H.L., CAI Q.Y., LIN C.C., PARK I.K., XU P., DONG J., KIM C., HE Q.C., PENG R.P., CHEN C.Y., Vermeulen R., WU J.J., LIM W.Y., CHEN K.C., CHAN J.K.C., CHU M.J., LI Y.J., LI J.H., CHEN H.Y., YU C.J., JIN L., LO Y.L., CHEN Y.H., Fraumeni J.F., LIU J., Yamaji T., YANG Y., HICKS B., WYATT K., LI S.A., DAI J.C., MA H.X., JIN G.F., SONG B., WANG Z.H., CHENG S.S., LI X.L., REN Y.W., CUI P., Iwasaki M., Shimazu T., Tsugane S., ZHU J.J., Jiang G.N., FEI K., WU G.P., CHIEN L.H., CHEN H.L., SU Y.C., TSAI F.Y., CHEN Y.S., YU J.M., Stevens V.L., Laird-Offringa L.A., Marconett C.N., LIN D.X., CHEN K., WU Y.L., LANDI M.T., SHEN H.B., Rothman N., Kohno T., CHanock S.J. and Lan Q., Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations , Human Molecular Genetics. 2016, ddw414.

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