Dept of Medicine

DEPT OF MEDICINE

Researcher : Au KW

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Au KY

List of Research Outputs

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : BAI Y

List of Research Outputs

BAI Y., Wong K.Y., Fung T.K. and Chim J.C.S., High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes, Journal of Hematology & Oncology. 2016.

Researcher : Bu L

Project Title:	Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):	Bu L, Li RA
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2012

Researcher : But YKD

List of Research Outputs

Chan H.L., Tsang O.T., Hui Y.T., Fung J.Y.Y., Lui G.C., Lai C.L., Wong G.L., Chan K.H., But Y.K.D., Lai M.S., Lao W.C., Chan C., Lam Y.S., Seto W.K.W., Li C., Yuen R.M.F. and Wong V.W., Real-Life Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir in Chronic Hepatitis C Patients in Hong Kong, Journal of Gastroenterology and Hepatology. 2016, 32(6): 1230-33.

Leung W.K., But Y.K.D., Wong S.Y., Liu S.H.K. and Hung F.N.I., Prevention of Post-sphincterotomy Bleeding by Proton Pump Inhibitor: A Prospective Randomized Trial, 25th United European Gastroenterology Week, 15-19 Oct 2016, Vienna, Austria. 2016.

Researcher : CHAN KW

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : CHEN X

List of Research Outputs

CHEN X., Zheng C., Wu C.H. and Kwan S.K.J., Oral treatment with herbal formula B307 alleviates skeletal muscle atrophy from hind-limb unloading, 22nd Medical Research Conference. 2017.

CHEN X. and Kwan S.K.J., Systematic review of the evaluation paradigms used to assess behavior in zebrafish models of neurodegenerative diseases, 12th International Symposium on Healthy Aging. 2017.

Researcher : CHEN Y

List of Research Outputs

CHEN Y. and Yiu K.H., Growing importance of valvular heart disease in the elderly., J Thorac Dis. 2016, 8(12): E1701-1703.

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

Cao G., Chen C., CHEN Y., ZHEN Z., Zou Y., Liu J., Wu M., Wang R., Liu M., Zhao C., Lu S., Ng M.Y., Tse H.F. and Yiu K.H., Prevalence, clinical characteristics and echocardiography parameters of non-resistant, resistant and refractory hypertension in Chinese., Postgrad Med.. 2017, 129(2): 187-192.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

Researcher : CHER CY

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

He B.A., LAM S.Y., CHER C.Y., NG K.L. and Leung A.Y.H., Follistatin is a critical mediator for FLT3/ITD+ acute myeloid leukemia, Experimental Hematology. 2016, 44: S79.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : CHIU SM

List of Research Outputs

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Researcher : CHONG CK

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Researcher : CHOY HK

List of Research Outputs

CHOY H.K., Yung S.S.Y., LI N., Cheung K.F. and Chan D.T.M., EDA+ Fibronectin in Tubulo-interstitial Injury in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Researcher : CUI Y

List of Research Outputs

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Best Oral Presentation Award on Basic Science, 22nd Medical Research Conference (MRC), HKU. Hong Kong, Hong Kong Academy of Medicine Press, 2017, 23 (Supplement 1): 17.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Cigarette smoke medium induces apoptosis via the translocator protein (TSPO) in airway epithelial cells, American Thoracic Society (ATS) International Conference 2017, Am J Respir Crit Care Med . USA, ATS, 2017, 195: A6297.

CUI Y., Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells, Toxicology Letters. 2017, 268: 44-50.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Selegeline suppressed cigarette smoke medium (CSM)-induced oxidative stress, inflammation and apoptosis via monoamine oxidase-B inhibition in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 17.

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Researcher : Chai YH

List of Research Outputs

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : Chan CYJ

Project Title:	Registry of Severe Cutaneous Adverse Drug Reactions and Epidemiological study in Hong Kong (RESCUE-HK)
Investigator(s):	Chan CYJ, Cheung BMY, Wong ICK, Cheung CL, Yeung CK, Shih KC, Chan CLR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

List of Research Outputs

Chow L.W.L., Ng L.K.A., Chow S.W.S., Choy N.K.B., Shih K.C., Wong Y.H.I., Chan C.Y.J. and Lai J.S.M., A cross-sectional comparative study on chronic ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series, International Ophthalmology. 2017.

Chow L.W.L., Shih K.C., Chan C.Y.J., Lai J.S.M. and Ng L.K.A., Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study, BMC Ophthalmology. 2017, 17.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

SING C.W., Wong I.C.K., Cheung B.M.Y., Chan C.Y.J., Chu K.P.J. and Cheung C.L., Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study, Pharmacoepidemiology and Drug Safety. 2017, 26: 248-255.

Researcher : Chan DTM

Project Title:	Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Gut Microbiota Products in the Pathogenesis of Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY, Yap YHD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

Project Title:	The Role of CD44 in the Pathogenesis of Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	The role of hepatocyte growth factor in lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014
Completion Date:	10/2016

Project Title:	The role of Ku70 and Ku80 in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Measurement of inflammatory and fibrotic mediators in serum and their association with vascular injury in patients with lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015
Completion Date:	04/2017

Project Title:	The Role of Major Vault Protein in Tubulo-interstitial Injury during Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	ASN Kidney Week 2015 Annual Meeting; Serum Acetate and Lipopolysaccharide Levels Correlate with Disease Activity in Patients with Lupus Nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2015

Project Title:	The roles of lipopolysaccharide, lipopolysaccharide binding protein and CD14 in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	The role of lysophosphatidic acid in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	ASN Kidney Week 2016 Annual Meeting; Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	Acetate in the Pathogenesis of Lupus Nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Role of Major Vault Protein in Fibrotic Processes in Human Mesangial Cells and Proximal Renal Tubular Epithelial Cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

CHOY H.K., Yung S.S.Y., LI N., Cheung K.F. and Chan D.T.M., EDA+ Fibronectin in Tubulo-interstitial Injury in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Chan D.T.M., Zhang Q., Chau K.M., Chan P.L. and Yung S.S.Y., Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis, ASN Kidney Week 2016.

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Chan D.T.M., “Advances in lupus nephritis management” at Annual Nephrology Convention of the Philippine Society of Nephrology, 29 March to 1 April 2017, Manila, Philippines., 2017.

Chan D.T.M., “Advances in the treatment of lupus nephritis” and “Factors and interventions for chronic renal allograft failure” at 6th Oriental Congress of Nephrology, organized by the Shanghai Society of Nephrology and endorsed by International Society of Nephrology, 2-4 Sept 2016, Shanghai, China., 2016.

Chan D.T.M., “Cross-talk between clinical and translational research in lupus nephritis” and “Lessons learnt from randomized controlled trials in lupus nephritis” at the 12th International SLE Congress, 26-29 March 2017, Melbourne, Australia., 2017.

Chan D.T.M., “Difficult cases of lupus nephritis” Plenary Lecture at 40th Anniversary Annual Scientific Meeting of Nephrology Society of Thailand, 30-31 July 2016, Pattaya, Thailand., 2016.

Chan D.T.M., “HBV and HCV in kidney transplant recipients and donor” at Asian Transplantation Week 2016, organized by the Seoul National University, 27-29 October, 2016, Incheon, Korea., 2016.

Chan D.T.M., “Re-transplantation or Restarting Dialysis: the Choice, the Timing, the Work-up, and the Risks” in the 26th International Congress of The Transplantation Society, 18-23 August 2016, Hong Kong., 2016.

Chan D.T.M., “Recent advances in the management of lupus nephritis”, Annual Meeting of Macau Society of Nephrology, 23rd October, 2016., 2016.

Chan D.T.M., “Therapy and Outcome of Lupus Nephritis in 2016” at meeting of Taiwan Society of Nephrology, 29 Oct 2016, Taipei, Taiwan; and “Treatment of Lupus Nephritis – Lessons Learnt from Clinical and Translational Studies” at meeting of China Society of Immunology, 30 Oct 2016, Taichung, Taiwan., 2016.

Chan D.T.M., “Therapy and outcome of lupus nephritis in 2016”, Annual Congress of the Chinese Society of Nephrology, 12-15 Oct 2016, Chongqing, PRC., 2016.

Chan D.T.M., “Update on Hepatitis B Infection and Kidney Transplantation” in the 15th Asian Pacific Congress of Nephrology & 52nd Australian and New Zealand Society of Nephrology Annual Scientific Meeting, Asian Pacific Society of Nephrology, 17-21 September 2016, Perth, Australia., 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding Immunoglobulin G Level Correlates with Clinical and Renal Histological Disease Activity in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding immunoglobulin level correlates with renal histological features in lupus nephritis, ASN Kidney Week 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D., Chan K.W., Lee C.K., Tang S.O.C. and Chan D.T.M., Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations, Clinical Science. 2017, 131: 653-671.

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Li S., Ip K.M., Tang Y.H., Sy K.H.S., Yung S.S.Y., Chan D.T.M., Yang M.S., Shum H.C. and Wong A.S.T., Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice, Journal of Visualized Experiments. 2017.

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Fang X.H.B., Choy C.B.Y. and Chan D.T.M., Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient, Journal of the Formosan Medical Association. 2017, Epub ahead of print.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Shum H.P., Yan W.W. and Chan D.T.M., Extracorporeal blood purification for sepsis, Hong Kong Medical Journal. 2016.

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553.

Yap Y.H.D., Chan J.F.W., Yip T., Mok M.M., Kwan L., Lo W.K. and Chan D.T.M., Burkholderia Cepacia Exit-site infection in peritoneal dialysis patients - clinical characteristics and treatment outcomes, Peritoneal Dialysis International. 2016, 36(4): 390-394.

Yap Y.H.D., Lee P., Yung S.S.Y. and Chan D.T.M., Circulating lymphocyte subsets and disease relapse in lupus nephritis, ASN Kidney Week 2016 Annual Meeting, Chicago, America. 2016.

Yap Y.H.D., Lee P., Yam I.Y.L., Tam H.Y., Wong S., Yung S.S.Y. and Chan D.T.M., Effect of Cyclophosphamide and Mycophelonate Mofetil on Lymphocyte Subsets in Patient with Active Lupus Nephritis, 54th Congress of European Renal Association-European Dialysis and Transplant Association , Madrid, Spain. 2017.

Yap Y.H.D. and Chan D.T.M., LONG-TERM DATA ON SIROLIMUS TREATMENT IN LUPUS NEPHRITIS PATIENTS, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yap Y.H.D. and Chan D.T.M., PRE-EMPTIVE TREATMENT FOR ASYMPTOMATIC SEROLOGICAL REACTIVATION IN LUPUS NEPHRITIS PATIENTS – IMPACT ON CLINICAL FLARE RATE AND RENAL FUNCTION, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y.M., Chan C.W.G., Kwan P.Y.L. and Chan D.T.M., RELAPSE OF LUPUS NEPHRITIS – RISK FACTORS AND IMPACT OF MYCOPHENOLATE TREATMENT, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Yung S.S.Y. and Chan D.T.M., Anti-dsDNA antibodies and resident renal cells — Their putative roles in pathogenesis of renal lesions in lupus nephritis, Clinical Immunology. 2016, pii:S1521-6616(16)30361-30368.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Chu J.Y.S., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells, ASN Kidney Week 2016.

Yung S.S.Y., Yap Y.H.D. and Chan D.T.M., Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis, F1000Research. 2017, 6: 874.

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : Chan GCW

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Yap Y.H.D., Seto W.K.W., Fung J.Y.Y., Chok K.S.H., Chan S.C., Chan G.C.W., Yuen R.M.F. and Chan T.M., Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis, Digestive and Liver Disease. 2016, 49(2): 202-206.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Chan HHL, Lam LK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2000

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Chan HHL, Wei WI
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	11/2001

List of Research Outputs

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Chan JCK, Lam WK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	07/1995

Researcher : Chan KH

Project Title:	Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	01/2008

Project Title:	Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):	Chan KH, Ho SL
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	03/2008

Project Title:	The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):	Chan KH, Ho WL
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	04/2009

Project Title:	Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):	Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2010

Project Title:	Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):	Chan KH, Ho WL
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	06/2011

Project Title:	Adiponectin gene therapy in mouse model of Alzheimer’s disease (CRF)
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	Investigation of adiponectin gene therapy in an animal model of Alzheimer's disease
Investigator(s):	Chan KH, Ng CL, Chung SK
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

Project Title:	Longitudinal MRI Study of local multiple sclerosis patients using quantitative conventional MRI and advanced MRI techniques
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Novartis Pharmaceuticals (HK) Ltd
Start Date:	01/2017

Project Title:	Pathogenicity of AQP4-IgG autoantibodies in neuromyeltiis optica: role of astrocytic activation in the absence of complement activation
Investigator(s):	Chan KH, Yick LW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Chan K.H., Advances In Neuroimaging For Multiple Sclerosis And Related Disorders, Fifth Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. 2016.

Chan K.H., Advances in multiple sclerosis, Headline News. 2016.

Chan K.H., Case Sharing on Alemtuzumab, Evolving Treatment Algorithm for Multiple Sclerosis. 2017.

Chan K.H., Chairmanship of Symposium on Parkinson's Disease, 12th International Symposium on Healthy Aging, Research Center of Heart, Brain & Healthy Aging, LKS Faculty of Medicine, HKU. 2017.

Chan K.H., Clinical Features, Neuroimaging, Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders. 2016.

Chan K.H., GRF Incentive Award, Department of Medicine, LKS Faculty of Medicine, HKU. 2016.

Chan K.H., Ng C.L. and Yick L.W., Immunopathological Effects Of Aquaporin-4 IgG In Neuromyelitis Optica Spectrum Disorders, MOJ Immunology. 2017, 5(5): 00168.

Chan K.H., Member of Editorial Board, Journal of Clinical & Experimental Immunology . 2016.

Chan K.H., Multiple Sclerosis, The Hong Kong Medical Diary. 2017, 22(3): 20-22.

Chan K.H., Neuroimmunology: Editorial, The Hong Kong Medical Diary. 2017, 22(3): 2-3.

Chan K.H., Neuroimmunology: The Cover Shot, The Hong Kong Medical Diary. 2017, 22(3): 1.

Chan K.H., Neuroinflammation and Related Treatment in AD, International Alzheimer's Disease Conference 2017 Advances in Dementia Research and Care. 2017.

Chan K.H., Neuroinflammation and Related Treatment in Alzheimer's Disease, International Alzheimer's Disease Conference 2017: Advances in Dementia Research and Care. 2017.

Chan K.H., Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders, The Hong Kong Medical Diary. 2017, 22(3): 23-27.

Chan K.H., Publication Award, Department of Medicine, LKS Faculty of Medicine, HKU. 2017.

Chan K.H., Upcoming Therapies in Multiple Sclerosis, APAC MS Summit 2016. 2016.

Cheung R.H.K., Chan K.H. and Lee R., Haemorrhagic transformation of ischaemic stroke: risk factors and prognostic implication, 22nd Medical Research Conference. 2017, 23: 15.

Lau G.K.K., Li L., Schulz U., Simoni S., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke – validation in two large cohorts, 3rd European Stroke Organisation Conference. 2017.

Lau G.K.K., Li L., Schulz U., Simoni M., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke: validation in 2 large cohorts, Neurology. 2017, 88: 2260-2267.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.Y., Mak H.K.F., Chiu P.W., Chang H.C.C., Barkhof F. and Chan K.H., Differential brainstem atrophy in multiple sclerosis and neuromyelitis optica spectrum disorders among Hong Kong Chinese, 22nd Medical Research Conference. 2017, 23: 29.

Lee C.Y. and Chan K.H., Mutliple sclerosis - updates in management, The Hong Kong Practitioner. 2016, 38: 1-10.

Leung S.T.S. and Chan K.H., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 32th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), London. 2016.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Ng C.L. and Chan K.H., Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease, In: Katalin Prokai-Tatrai, International Journal of Molecular Sciences. 2017, 18: 592.

Qian W., Chan K.H., Hui S.K., Lee C.Y., Hu Y. and Mak H.K.F., Application of diffusional kurtosis imaging to detect occult brain damages in multiple sclerosis and neuromyelitis optica, NMR in Biomedicine. 2016.

Teo K.C., Lee C.Y., Chang S.K.R., Ho S.L. and Chan K.H., Aetiology, clinical presentation, and outcome of encephalitis in Hong Kong, 22nd Medical Research Conference. 2017, 23: 42.

XU X., Mak H.K.F., Chan K.H., Lee C.Y. and Hui S.K., Distinction between neuromyelitis optica and multiple sclerosis - from a structural brain network perspective, The 33rd Annual Scientific Meeting of ESMRMB, Vienna, Austria. 2016.

Zhang K., Guo Y., Ge Z., Zhang Z., Da Y., Li Y., Ren Y., Chan K.H., Yang F., Yan J., Yao Z. and Zhang R., Adiponectin suppresses T helper 17 cell differentiation and limitis autoimmune CNS inflammation via the SIRT1/PPARγ/RORγt pathway, Molecular Neurobiology. 2016.

Researcher : Chan KWK

List of Research Outputs

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Researcher : Chan MMW

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2001

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Researcher : Chan PHM

Project Title:	Left Atrial Volume by Computed Tomography in prediction of New onset Atrial Fibrillation
Investigator(s):	Chan PHM, Siu DCW, She HLH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease
Investigator(s):	Chan PHM, She HLH, Tse HF, Chan WS, Siu DCW, Cheung CWS
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease
Investigator(s):	Chan PHM, Ng MY, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management
Investigator(s):	Chan PHM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk
Investigator(s):	Chan PHM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Prospective evaluation of the impact of Drug-Coated Balloon in the management of true coronary bifurcation disease
Investigator(s):	Chan PHM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Chan P.H.M., Wong C.K., Poh Y.C., Pun L., Leung W.W., Wong Y.F., Wong M.M., Poh M.Z., Chu D.W. and Siu D.C.W., Diagnostic Performance of a Smartphone‐Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting, Journal of the American Heart Association. 2016, 5: e003428.

Chan P.H.M., Wong C.K., Pun L., Wong Y.F., Wong M.M., Chu D.W. and Siu D.C.W., Diagnostic performance of an automatic blood pressure measurement device, Microlife WatchBP Home A, for atrial fibrillation screening in a real-world primary care setting, BMJ Open. 2017, 7: e013685.

Chan P.H.M., Wong C.K., Pun L., Wong Y.F., Wong M.M., Chu D.W. and Siu D.C.W., Head-to-Head Comparison of the AliveCor Heart Monitor and Microlife WatchBP Office AFIB for Atrial Fibrillation Screening in a Primary Care Setting, Circulation. 2017, 135: 110-112.

Chan P.H.M. and Siu D.C.W., Letter by Chan and Siu Regarding Article, “Use of Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation Who Have a History of Intracranial Hemorrhage”, Circulation. 2016, 134: e226-e227.

Chan P.H.M., Real world experience of SPAF management in Hong Kong, 4th TCM SPAF Academy. 2016.

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Hai S.H.J.J., Wong C.K., Chan P.H.M., Tse H.F., Yung T.C. and Siu D.C.W., Quinidine for Brugada syndrome: Panacea or poison?, HeartRhythm Case Rep.. 2016, 2(6): 486-490.

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Wong C.K., Chan P.H.M. and Siu D.C.W., Letter by Wong et al Regarding Article, “Pregnancy and the Risk of Aortic Dissection or Rupture: A Cohort-Crossover Analysis”, Circulation. 2017, 135: e780-e781.

Researcher : Chan PL

List of Research Outputs

Chan D.T.M., Zhang Q., Chau K.M., Chan P.L. and Yung S.S.Y., Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis, ASN Kidney Week 2016.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : Chan SYT

List of Research Outputs

Chan S.Y.T., Tse E.W.C. and Kwong Y.L., Chidamide in the treatment of peripheral T-cell lymphoma, OncoTargets and Therapy. 2017, Volume 10: 347-352.

Chan S.Y.T., Luk T.H., Lau J.S., Khong P.L. and Kwong Y.L., Low-dose pembrolizumab for relapsed/refractory Hodgkin lymphoma: high efficacy with minimal toxicity, Annals of Hematology. 2017, 96: 647-651.

Chan S.Y.T., Khong P.L. and Kwong Y.L., Pembrolizumab and lenalidomide induced remission in refractory double-hit lymphoma, Annals of Hematology. 2016.

Chan S.Y.T., Khong P.L. and Kwong Y.L., Pembrolizumab for relapsed anaplastic large cell lymphoma after allogeneic haematopoietic stem cell transplantation: efficacy and safety, Annals of Hematology. 2016.

Chan S.Y.T., Lee E.Y.P., Khong P.L., Tse E.W.C. and Kwong Y.L., Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma, Hematology. 2017, 1-7.

Kwong Y.L., Chan S.Y.T., Tan D., Kim S.J., Poon L.M., Mow B., Khong P.L., Loong F., Au Yeung K.H.R., Iqbal J., Phipps C. and Tse E.W.C., PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase, Blood. 2017, 129: 2437-2442.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Researcher : Chan TCI

List of Research Outputs

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Researcher : Chan VNY

Project Title:	Hepatitis B virus array for genotyping and mutation detection
Investigator(s):	Chan VNY, Lai CL, Chan K, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2006

Researcher : Chan VSF

Project Title:	A study of interferon-induced chemokines signature in lupus nephritis development
Investigator(s):	Chan VSF, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	17th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2017) & Computational Immunology Course; Autoimmune-associated CLEC16A modulates inflammasome activity in human macrophages
Investigator(s):	Chan VSF
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

Chan V.S.F., Autoimmune-associated CLEC16A modulates inflammasome activity in human macrophages, 17th Annual Meeting of the Federation of Clinical Immunology Societies. FOCIS 2017.

Chan V.S.F., Editorial Board Member, International Journal of Molecular Sciences. Basel, Switzerland, MPDI AG, 2017, Molecular Diagnostics.

Chan V.S.F., Innate Immunity in Systemic Lupus Erythematosus – plasmacytoid dendritic cells and inflammasomes, 2017 International Symposium on Allergy and Immunology Changsha, China. 2017.

Huang X., Wu H., Qiu H., Yang H., Deng Y., Zhao M., Luo H., Zhou X., Xie Y., Chan V.S.F., Lau W.C.S. and Lu Q., The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus, Clinical Immunology. 2016, 173: 161-170.

Li W.M.M., YIM L.Y., Chan V.S.F. and Lau W.C.S., Autoimmune-associated Gene Clec16a Regulates Nlrp3 But Not Aim2 Inflammasome Pathway In Human Macrophages, Asian Congress of Autoimmunity 2017 & Lupus 2017.

Qiu H., Wu H., Chan V.S.F., Lau W.C.S. and Lu Q., Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity, Autoimmunity. 2017, 50: 71-81.

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

YIM L.Y., YAN S., LEE C.P., Chan V.S.F. and Lau W.C.S., Dendritic cells display aberrant Toll-like receptor 7/9 responses in systemic lupus erythematosus, Asian Congress on Autoimmunity 2017 & Lupus 2017.

Yan S., Yim L.Y., Tam C.Y., Chan W.K., Lu L., Lau W.C.S. and Chan V.S.F., MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice, International Journal of Molecular Sciences. 2016, 17: 1282.

Zhang Q., Ding S., Zhang H., Long H., Wu H., Zhao M., Chan V.S.F., Lau W.C.S. and Lu Q., Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus., Clin Epigenetics. 2016, 8: 126.

Researcher : Chan WK

List of Research Outputs

Yan S., Yim L.Y., Tam C.Y., Chan W.K., Lu L., Lau W.C.S. and Chan V.S.F., MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice, International Journal of Molecular Sciences. 2016, 17: 1282.

Researcher : Chan WS

List of Research Outputs

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Researcher : Chan YY

List of Research Outputs

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Chang SKR

List of Research Outputs

Cheung R.T.F., Xiong L., Chang S.K.R., Tse C.T.A., Pang S.Y.Y., Mok V., Leung T., Tsoi T.H., Li R., Mok M., Chang C.M., Lau K.K., Sheung B., Li T., Yeung J., Leung P.C., Chook P. and Wong K.S., Herbs and Rehabilitation after Stroke Study: A Multi-center, Double-blinded, Randomized Trial in Hong Kong, Journal of Stroke. 2016, 18: 361-363.

Teo K.C., Lee C.Y., Chang S.K.R., Ho S.L. and Chan K.H., Aetiology, clinical presentation, and outcome of encephalitis in Hong Kong, 22nd Medical Research Conference. 2017, 23: 42.

Researcher : Chau HWD

List of Research Outputs

PIAO W., Chau H.W.D., Yue L.M., Kwong Y.L. and Tse E.W.C., Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma, Leukemia. 2017, 31: 522-526.

Researcher : Chau KF

List of Research Outputs

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Researcher : Chau KM

List of Research Outputs

Chan D.T.M., Zhang Q., Chau K.M., Chan P.L. and Yung S.S.Y., Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis, ASN Kidney Week 2016.

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding Immunoglobulin G Level Correlates with Clinical and Renal Histological Disease Activity in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding immunoglobulin level correlates with renal histological features in lupus nephritis, ASN Kidney Week 2016.

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Chu J.Y.S., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells, ASN Kidney Week 2016.

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : Chen L

List of Research Outputs

Leung W.K., Chan E.W., Wong Y.S., Chen L., Wong O.L., Wong I.C. and Cheung M.K.S., Age of Helicobacter pylori Eradication and Subsequent Risk of Gastric Cancer Development: A Population-Based Study, Digestive Disease Week, 6-9 May 2017, Chicago, USA. 2017.

Researcher : Chen WH

Project Title:	Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2001

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Researcher : Chen Y

List of Research Outputs

CHEN Y. and Yiu K.H., Growing importance of valvular heart disease in the elderly., J Thorac Dis. 2016, 8(12): E1701-1703.

Researcher : Cheng CTK

List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Researcher : Cheng CW

List of Research Outputs

Cheng C.W., Leong K.W. and Tse E.W.C., Understanding the role of PIN1 in hepatocellular carcinoma, World Journal of Gastroenterology. 2016.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Researcher : Cheng CYS

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Researcher : Cheng IKP

List of Research Outputs

Chu K.K.W., Chan S.C., Sin S.L., Chan A.C.Y., Chok K.S.H., Cheng I.K.P. and Lo C.M., Lipid profiles of donors and recipients of liver transplant: like father like son, Hepatology International. 2017, 11(3): 300-305.

Researcher : Cheng KY

Project Title:	The adaptor protein APPL2 as a physiological modulator of pancreatic β-cell functions in mice
Investigator(s):	Cheng KY, Cheung YY
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	The MDM2-p53 pathway as a novel regulator of glucose-stimulated insulin secretion in pancreatic beta cells
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in adipose tissues
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	APPL2 as a key mediator of white-to-beige fat transdifferentiation
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	The novel role of hematopoietic APPL1 in regulating adipose tissue inflammation and insulin resistance in obesity
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016
Completion Date:	12/2016

Project Title:	The role of adipocyte turnover in regulation of systemic energy and glucose homeostasis
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

Jang H., Lee G.Y., Selby C.P., Lee G., Jeon Y.G., Lee J.H., Cheng K.Y., Titchenell P., Birnbaum M.J., Xu A., Sancar A. and Kim J.B., SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. , Nature Communications. 2016, 7.

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Researcher : Cheng OY

List of Research Outputs

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Researcher : Cheng YY

Project Title:	The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):	Cheng YY, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008

Researcher : Cheung AJ

List of Research Outputs

Cheung A.J. and Cheung B.M.Y., Systolic blood pressure is strongly related to indices of obesity in children., Presented at the European Society of Cardiology Congress 2016, Rome. 2016.

Researcher : Cheung BMY

Project Title:	Accelerating the Development of Pharmacogenomics at HKU through a Systems Biology Approach
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Innovative Research Grants
Start Date:	07/2013

Project Title:	The 10th Scientific Conference on Cardiovascular Science Across the Strait
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2015

Project Title:	Use of medications for osteoporosis in Hong Kong
Investigator(s):	Cheung BMY, Cheung CL, Cheung TT, Woo YC
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2017

Project Title:	Hypertension Seoul 2016; Plasma level of fibroblast growth factor 21 is independently related to blood pressure
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2016
Completion Date:	09/2016

Project Title:	A metabolomic study to reveal how phytosterols improve the lipid profile
Investigator(s):	Cheung BMY, Cheung CL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Cheung A., Cheung K. and Cheung B.M.Y., Waist circumference as a predictor of glycohemoglobin (A1C) in the US population., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.

Cheung A.J. and Cheung B.M.Y., Systolic blood pressure is strongly related to indices of obesity in children., Presented at the European Society of Cardiology Congress 2016, Rome. 2016.

Cheung A.J., Cheung K.Y.C. and Cheung B.M.Y., Waist circumference as a predictor of glycohemoglobin (A1C) in the US population., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Cheung B.M.Y., Cheng C.H., Lau C.P., Wong C.K.Y., Ma R.C.W., Chu D.W.S., Ho D.H.K., Lee K.L.F., Tse H.F., Wong A.S.P., Yan B.P.Y. and Yan W.T., 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population, Hong Kong Medical Journal. 2017, 191-201.

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Chan E.Y.T., Tsui M.S.H. and Lee S.W.L., Beta-2 microglobulin level in serum is elevated in patients presenting with acute coronary syndrome., Presented at the Great Wall International Congress of Cardiology, Beijing 2016.. 2016.

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Cheung B.M.Y., wang Y., Lam K.S.L. and Tse H.F., Is endothelial function related to plasma level of lipocalin-2 in man?, Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Cheung B.M.Y., Fong C.H.Y., Chen C., Cho A.W.K., Wang Y., Law L.S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., LBPS 02-06 PLASMA LEVEL OF FIBROBLAST GROWTH FACTOR 21 IS INDEPENDENTLY RELATED TO BLOOD PRESSURE, Journal of Hypertension. 2016, 34: e507.

Cheung B.M.Y., tam F., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E.Y.T., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Cheung C.L., Leung Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C. and Tan K.C.B., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese., American Society for Bone and Mineral Research Annual Meeting, Atlanta, Sept 2016.. 2016.

Cheung C.L., Ho D.K., SING C.W., TSOI M.F., CHENG K.F., LEE K.Y., Ho Y.N. and Cheung B.M.Y., Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese, Scientific Reports. 2017, 7: 41084.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., . Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., . Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 25th Annual Scientific Congress of the Hong Kong College of Cardiology, 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of randomized controlled trials, International Journal of Cardiology. 2016, 220: 895-900.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: network meta-analysis of randomised controlled trials. ., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016. Young Investigator Award. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal systolic blood pressure target for hypertensive patients: a network meta-analysis., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FU S.N., Dao M.C., Luk W., Ho I.S.F., Lam M.C.H., Cheung S.K. and Cheung B.M.Y., Empowering patients to better blood pressure control: a qualitative study of patients’ views, practice and response to self-blood pressure monitoring (SBPM)., Presented at the Hospital Authority Convention, Hong Kong 2017.. 2017.

FU S.N., Dao M.C., Luk W., Ho S.F., Lam C.H., Cheung S.K., Wong C.K.H. and Cheung B.M.Y., Improving Quality of Home Blood Pressure Monitoring in Uncontrolled Hypertension: A Randomised Control Trial Protocol, 2016 Primary Health Care Research Conference, The National Convention Centre, Canberra from 8-9 June 2016.. 2016.

Huang Z., Xu A. and Cheung B.M.Y., The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension, Current Hypertension Reports. 2017, 19.

Kumana C.R. and Cheung B.M.Y., Empagliflozin therapy for type 2 diabetes: viewing possible benefits in relative and absolute terms. ., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.

LEUNG Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C., Tan K.C.B. and Cheung C.L., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese, Bone. 2017, 97: 293-298.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Woo Y.C., Yuen M.M.A., Fong H.Y., Cheung B.M.Y. and Lam K.S.L., Obesity indices in the prediction of incident type 2 diabetes mellitus in a long- term cohort study of Hong Kong Chinese, The International Diabetes Federation World Diabetes Congressm Vancouver, Canada . 2016.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese, Thrombosis and Haemostasis. 2016, 117: 158-163.

SING C.W., Wong I.C.K., Cheung B.M.Y., Chan C.Y.J., Chu K.P.J. and Cheung C.L., Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study, Pharmacoepidemiology and Drug Safety. 2017, 26: 248-255.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung B.M.Y. and Cheung T.T., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Chu C.H.A., Cheung T.T. and Cheung B.M.Y., Hyperlipidemic effect of janus kinase inhibitors: a meta-analysis., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., Treatment of calcium channel blocker overdose: a case series., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

YANG K., Deng H., MAN W.C., SONG E., Zhang J., Luo C., Cheung B.M.Y., Yuen K.Y., Jensen P.S., Irmukhamedov A., Elie A...G...I...M., Vanhoutte P.M.G.R., Xu A., De Mey J.G.R. and Wang Y., Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment, ESC Heart Failure. 2017, 1-13.

Researcher : Cheung CL

Project Title:	Genetics and genomics of anti-thyroid drug induced agranulocytosis
Investigator(s):	Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study
Investigator(s):	Cheung CL, Tan KCB, Kung AWC, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

Project Title:	Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study
Investigator(s):	Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Precision Medicine of Osteoporosis Medication in Chinese (PreMOMiC): A retrospective and prospective pharmacogenomic study of denosumab
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2017

Project Title:	Metabolomic Study of Osteoporosis in Southern Chinese
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2016

Project Title:	Identification of susceptibility genes involved in the pathogenesis and prediction of thyrotoxic periodic paralysis
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2017

Project Title:	*Genetic screening service of HLA-B38:02 in people prescribing antithyroid drug**
Investigator(s):	Cheung CL, Tan KCB, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2017

Project Title:	The 44th European Calcified Tissue Society (ECTS) Congress 2017; Early anti-osteoporosis treatment and risk of cardiovascular mortality after hip fracture: A population based study
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

Researcher : Cheung CY

List of Research Outputs

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Researcher : Cheung KF

List of Research Outputs

CHOY H.K., Yung S.S.Y., LI N., Cheung K.F. and Chan D.T.M., EDA+ Fibronectin in Tubulo-interstitial Injury in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding Immunoglobulin G Level Correlates with Clinical and Renal Histological Disease Activity in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding immunoglobulin level correlates with renal histological features in lupus nephritis, ASN Kidney Week 2016.

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Researcher : Cheung RTF

Project Title:	Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2005

Project Title:	Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

Project Title:	Neuroprotection of melatonin and calpeptin in a rat ischemic stroke model
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014
Completion Date:	04/2017

List of Research Outputs

CHENG K.Y., Chan K.M.K., Wong C.S., Cheung R.T.F., Li L.S.W. and CHIU M.Y., Motor Evoked Potentials Of The Tongue In Healthy Adults And Dysphagic Individuals, 6th European Society for Swallowing Disorders Congress. 2016.

CHENG K.Y., Chan K.M.K., Wong C.S., Cheung R.T.F., Li L.S.W. and CHIU M.Y., Short Term Effects Of 5hz Repetitive Transcranial Magnetic Stimulation (rtms) On Swallowing And Speech Functions In Post-stroke Individuals. , 6th European Society for Swallowing Disorders Congress. 2016.

CHENG K.Y., Chan K.M.K., Wong C.S., Li L.S.W., CHIU M.Y. and Cheung R.T.F., Use of 5Hz rTMS to improve speech functions in post-stroke dysarthric patients., 39th Australasian Society for the Study of Brain Impairment Annual Brain Impairment Conference. 2016.

Cheung R.T.F., Associate Editor, Advances in Alzheimer's Disease. Scientific Research Publishing, 2017.

Cheung R.T.F., Associate Editor, Journal of Alzheimer’s Disease. IOS Press, 2016.

Cheung R.T.F., Chairman of Organizing Committee, Hong Kong Medical Forum 2017, University Department of Medicine, Hong Kong Convention & Exhibition Centre, Wanchai, Hong Kong, May 13 to 14 2017. 2017.

Cheung R.T.F., Editorial Board, Asian Journal of Neuroscience. Hindawi Publishing, 2017.

Cheung R.T.F., Editorial Board, Austin Journal of Anatomy. Austin Publishing Group, 2016.

Cheung R.T.F., Editorial Board, Austin Journal of Cerebrovascular Disease & Stroke. Austin Publishing Group, 2017.

Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2017.

Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2017.

Cheung R.T.F., Editorial Board, Edorium Journal of Neurology. Edorium Journal, 2017.

Cheung R.T.F., Editorial Board, JSM Ophthalmology. JSciMedCentral, 2017.

Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2017.

Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2017.

Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2017.

Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2017.

Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2017.

Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2017.

Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2017.

Cheung R.T.F., Editorial Board, World Journal of Biological Chemistry. Baishideng Publishing Group, 2017.

Cheung R.T.F., Xiong L., Chang S.K.R., Tse C.T.A., Pang S.Y.Y., Mok V., Leung T., Tsoi T.H., Li R., Mok M., Chang C.M., Lau K.K., Sheung B., Li T., Yeung J., Leung P.C., Chook P. and Wong K.S., Herbs and Rehabilitation after Stroke Study: A Multi-center, Double-blinded, Randomized Trial in Hong Kong, Journal of Stroke. 2016, 18: 361-363.

Cheung R.T.F., Journal editor, SM Journal of Neurology and Neuroscience. SM Group, 2017.

Cheung R.T.F., Management of TIA – an Update, Emergency Medicine Commissioned Training Programme on Key Topics in Emergency Medicine 2017/18: Emergency Cardiology, Emergency Neurology, and Emergency Therapeutics, Hospital Authority Head Office. 2017.

Cheung R.T.F., Member of Organizing Committee, 2016 International Conference “Beyond the Formal Curriculum in Universities”, Wang Gungwu Lecture Hall, Graduate House, The University of Hong Kong, HK. 2016.

Cheung R.T.F., Regional Editor, Cardiovascular & Hematological Agents in Medicinal Chemistry. Bentham Science Publishers, 2016.

Cheung R.T.F., 中風的防治, In: 林露娟敎授 (主編), 育醫造才 – 探索醫學世界第四册, 香港大學李嘉誠醫學院, 2016, 26-28.

Lau G.K.K., Li L., Schulz U., Simoni S., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke – validation in two large cohorts, 3rd European Stroke Organisation Conference. 2017.

Lau G.K.K., Li L., Schulz U., Simoni M., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke: validation in 2 large cohorts, Neurology. 2017, 88: 2260-2267.

Researcher : Cheung TT

Project Title:	Cost of illness of Ankylosing Spondylitis in Hong Kong
Investigator(s):	Cheung TT, Lau WCS, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Correlation of Fibroblast Growth Factor 21 (FGF21) with paracetamol levels in patients with paracetamol poisoning
Investigator(s):	Cheung TT, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Relationship between drug levels of tutor necrosis factor inhibitors and the clinical and radiological response in patients with axial spondyloarthritis
Investigator(s):	Cheung TT, Cheung BMY, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

List of Research Outputs

Cheung T.T., Deputy Editor, Rheumatology Practice and Research. 2017.

Cheung T.T., The Roles of Pharmacokinetics and Pharmacodynamics in Clinical Trials, 3rd International Conference on Phase 1 and Early Phase Clinical Trials. 2016.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., . Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., . Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 25th Annual Scientific Congress of the Hong Kong College of Cardiology, 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of randomized controlled trials, International Journal of Cardiology. 2016, 220: 895-900.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: network meta-analysis of randomised controlled trials. ., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016. Young Investigator Award. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal systolic blood pressure target for hypertensive patients: a network meta-analysis., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung B.M.Y. and Cheung T.T., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Chu C.H.A., Cheung T.T. and Cheung B.M.Y., Hyperlipidemic effect of janus kinase inhibitors: a meta-analysis., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Cheung T.T., Lam M.P.S. and Cheung C.L., Safety of colchicine for gout: a ten-year survey of the Hong Kong population., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., Treatment of calcium channel blocker overdose: a case series., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Researcher : Cheung YY

Project Title:	Causal effect of adiposity in diabetic retinopathy: a Mendelian randomisation analysis
Investigator(s):	Cheung YY, Lam KSL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	Impact of genetic variants identified in genome-wide association studies and their possible interaction with hypertension on the risk of diabetic retinopathy
Investigator(s):	Cheung YY, Lam KSL, Sham PC, Wong DSH, Gangwani RA, Yuen MAM
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Researcher : Chim JCS

Project Title:	FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Lee Hysan Foundation - General Award
Start Date:	07/2008

Project Title:	Genetic study (FISH study) for personalized treatment of multiple myeloma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2012

Project Title:	Use of Bortezomib during conditioning of autologous stem cell transplantation of international stage III myeloma
Investigator(s):	Chim JCS, Kwong YL, Lie AKW
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2014

Project Title:	Mechanism study of the effect of microenviroment on RANKL expression in myeloma cells
Investigator(s):	Chim JCS, Wong KY
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	The role of minimal residual disease detection in multiple myeloma: a parallel investigation by next-generation sequencing and allele-specific oligonucleotide real-time quantitative PCR
Investigator(s):	Chim JCS, Wong KY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2016
Completion Date:	11/2016

Project Title:	Identification of methylated miRNAs in acute promyelocytic leukaemia and their potential clinical application
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

Project Title:	Application of two cycles of Bortezomib as Consolidation after autologous stem cell transplantation in multiple myeloma
Investigator(s):	Chim JCS, Tse EWC, Wong HYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2017

List of Research Outputs

BAI Y., Wong K.Y., Fung T.K. and Chim J.C.S., High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes, Journal of Hematology & Oncology. 2016.

Chan S.Y., Au Yeung K.H.R., Chim J.C.S., Wong C.Y. and Kwong Y.L., Disseminated fusarium infection after ibrutinib therapy in chronic lymphocytic leukaemia, Annals of Hematology. 2017, 96: 871-872.

Chim J.C.S., "Immunotherapy in myeloma & the Immunosuppressive micro-environment", B Cell Malignancies meeting, Seoul, Korea,. 2016.

Chim J.C.S., Choice of therapy for relapsed myeloma, 8th International Hematologic Malignancies Conference: Bridging the Gap (BTG 2017) in Bangkok, Thailand. 2017.

Chim J.C.S., Immunotherapy in myeloma & tumor microenvironment, Cross-Strait Hematology Summit in Fuzhou, China. 2016.

Chim J.C.S., Management of relapsed and refractory multiple myeloma, Highlight of American Society of Hematology (ASH) 2017 in Asia Pacific, Hong Kong. 2017.

Chim J.C.S., Multiple myeloma – MRD by Freelite Chain/Hevylite, Beijing Myeloma Summit 2017 in Beijing, China. 2017.

Chim J.C.S., Novel criteria for diagnosing multiple myeloma and their therapeutic implications, European Society for a Medical Oncology (ESMO) Asia Congress 2016, Singapore. 2016.

Chim J.C.S., “Immunotherapy in myeloma: Facts or Fiction?”, Cross-Strait Hematology Summit, Fuzhou, China. 2016.

Huang X.J., Liu K., Ritchie D., Andersson B., Lu J., Hou J., Burguera A.F., Wang J.X., Yeoh A., Yan C., Zhou D., Tan D., Kim D., Wu D., Shpall E., Kornblau S., Neelapu S., Hongeng S., Li J., Hu J., Zhang L., Wang M., Malhotra P., Jiang Q., Qin Y., Wong R., Champlin R., Hagemeister F., Westin J., Iyer S., Mathews V., Wang Y., Hu Y., Xiao Z., Shao Z., Orlowski R.Z., Chim J.C.S., Mulligan S., Sanz M., Ozawa K., Parmar S. and Issaragrisil S., Hematology oncology practice in the Asia-Pacific APHCON survey results from the 6th international hematologic malignancies conference: bridging the gap 2015, Beijing, China, Oncotarget. 2017.

LEE S.K., CHEN X., CHENG T.Y., CHEUNG W.K., CHUNG K.L.K., FUNG K.H., HO C.Y., HO K.Y.K., IP R.Y.Y., KO C.X., KONG K.T., KWAN H.S., EWING C.L.Y., WONG V.K.C. and Chim J.C.S., Review of Newly Registered Oncology Drugs in Hong Kong, Hong Kong Pharmaceutical Journal. 2016, 23: 86-97.

Lu L.U. .J., Hou H.O.U. .J., Liu L.I.U. .K.Y., Parmar P.A.R.M.A.R. .S., De La Fuente A D.E. .L.A. .F.U.E.N., Andersson B A.N.D.E.R.S.S.O.N., Yan Y.A.N. .C., Zhou Z.H.O.U. .D., Tan T.A.N. .D., Ritchie R.I.T.C.H.I.E. .D., Wu W.U. .D., Shpall S.H.P.A.L.L. .E., Laport L.A.P.O.R.T. .G.G., Li L.I. .J., Hu H.U. .J., Zhang Z.H.A.N.G. .L.S., Wang W.A.N.G. .M., Malhotra M.A.L.H.O.T.R.A. .P., Jiang J.I.A.N.G. .Q., Qin Q.I.N. .Y., Wong W.O.N.G. .R., Champlin C.H.A.M.P.L.I.N. .R., Issaragrisil I.S.S.A.R.A.G.R.I.S., Iyer I.Y.E.R. .S., Mathews V M.A.T.H.E.W.S. .V., Wang W.A.N.G. .Y., Hu H.U. .Y., Xiao X.I.A.O. .Z., Shao S.H.A.O. .Z., Rosengarten R.O.S.E.N.G.A.R.T.E., Steuernagle S.T.E.U.E.R.N.A.G.L., Xiao X.I.A.O. .J.H., Orlowski O.R.L.O.W.S.K.I. .R. and Chim J.C.S., Asia-Pacific Hematology Consortium Report on approach to multiple myeloma. Survey results from the 6th International Hematologic Malignancies Conference: Bridging the Gap 2015, Beijing, China, Leukemia & Lymphoma. 2016, 57: 1534-1538.

WANG L., Wong K.Y., LI Z. and Chim J.C.S., Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia, Oncotarget. 2016.

Researcher : Chiu JWY

Project Title:	A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):	Chiu WYJ, Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Researcher : Chiu KCP

List of Research Outputs

Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan S.K.J., Chiu K.C.P. and Lam L.C.W., Associations between neuropsychiatric symptoms, cognitive function, and daily functioning in elderly with early dementia, 38th Annual Meeting & Scientific Sessions. San Diego, California, Society of Behavioral Medicine, 2017.

Researcher : Chiu WYJ

Project Title:	A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):	Chiu WYJ, Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Shin V.Y., Cheuk W.Y., Au C.H., Wong L., Chan T.L., Lo J., Ma E. and Kwong A., A pilot study of molecular-guided neoadjuvant chemotherapy in patients with triple negative breast cancer , Global Breast Cancer Conference (GBCC) 2017 (20-22 April 2017). 2017.

Chiu W.Y.J., Anti-HER2 therapy in breast cancer, (Sponsored by Roche Philippine), Cebu, 9th February 2017. 2017.

Chiu W.Y.J., CDK4/6 inhibitor -- Asian data and real life experience, Chinese Society of Clinical Oncology (CSCO) Annual Meeting, XiaMen, September 2016, 23 September 2016. 2016.

Chiu W.Y.J., Clinical strategy to over Trastuzumab resistance, Philippine Society of Medical Oncology meeting, Manila, 26th October 2016, 2016.

Chiu W.Y.J., Early clinical trials on Asia, International Conference on Phase 1 and Early Phase Clinical Trials 2016, Hong Kong, 3rd November 2016, 2016.

Chiu W.Y.J., Expert perspectives: use of palbociclib in Asian patients, Breast cancer evening symposium, organised by HK Breast Cancer Foundation, Hong Kong, 22nd May 2017. 2017.

Chiu W.Y.J., Management of HR+ HER- metastatic breast cancer, Satellite symposium, Asia-Pacific Breast Cancer Summit, Hong Kong, 19th February 2017, 2017.

Chiu W.Y.J., Optimising anti-HER2 treatment in breast cancer, Speaker tour in Manila (Sponsored by Roche Philippine), 26 July 2016, 2016.

Chiu W.Y.J., Optimizing Anti-HER2 Treatment for Breast Cancer, Leading the Cure for Cancer (Sponsored by Roche Philippines), Manila, 18th November 2016. 2016.

Chiu W.Y.J., The role of CDK4/6 inhibitor in Asian breast cancer patients, Breast cancer evening symposium (Sponsored by Pfizer), Hong Kong, 7th February 2017, 2017.

Chiu W.Y.J., Update from ASCO 2017 - Systemic treatment of breast cancer, Hong Kong Breast Cancer Foundation Dinner Symposium 2017, Hong Kong, 26th June 2017, 2017.

Kwok G., Yau T.C.C., Chiu W.Y.J., Tse E.W.C. and Kwong Y.L., Pembrolizumab (Keytruda), Human Vaccines & Immunotherapeutics. 2016, 12: 2777-2789.

Researcher : Chong CK

List of Research Outputs

Researcher : Chow WS

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Luk A.O.Y., Hui E.M.T., Sin M.C., Yeung C.Y., Chow W.S., Ho A.Y.Y., Hung H.F., Kan E., Ng C.M., So W.Y., Yeung C.K., Chan K.S., Chan K.W., Chan P.F., Siu S.C., Tiu S.C., Yeung T.F., Chan J.C.N., Chan F.W.K., Chan C., Cheung N.T., Ho S.T., Lam K.S.L., Yu L.W.L., Chao D. and Lau I.T., Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database, Diabetes Care. 2017, 40: 928-935.

Researcher : Choy CBY

List of Research Outputs

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Fang X.H.B., Choy C.B.Y. and Chan D.T.M., Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient, Journal of the Formosan Medical Association. 2017, Epub ahead of print.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Chu CHA

List of Research Outputs

TSOI M.F., Chu C.H.A., Cheung T.T. and Cheung B.M.Y., Hyperlipidemic effect of janus kinase inhibitors: a meta-analysis., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Researcher : Chu JYS

List of Research Outputs

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Yung S.S.Y., Chu J.Y.S., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells, ASN Kidney Week 2016.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Chu LW, Lam KSL, Lee WHP
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2003

List of Research Outputs

Chen L.P., Fan Y., Kao P.Y., Ho D.T., Ha C.T.J., Chu L.W. and Song Y., Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimer's Disease: Evidence from a Southern Chinese Population, J Am Geriatr Soc.. 2017, 65(2): 332-339.

Chiu P.W., Zhang H., Ip I., Wong S.W.H., Liu T., Wong G.H.Y., Chan Q., Yau K.K.W., Chu L.W. and Mak H.K.F., Neurochemical Basis of the BOLD Change in Attention Control - a combined task-based fMRI and 1H-MRS, The 25th Annual Meeting of ISMRM, Honolulu, HI, USA. 2017.

Researcher : Chung ACK

Project Title:	Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):	Chung ACK, Lan HY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2008

Researcher : Chung HY

List of Research Outputs

Chan C.W.S., Chung H.Y., Lau W.C.S. and Tsang H.L.H., Spontaneous pneumomediastinum in a dermatomyositis patient with anti-melanoma differentiation-associated gene-5 antibody and interstitial lung disease despite an initial response to immunosuppressant, International Journal of Rheumatic Diseases. 2017.

Chung H.Y., Lau W.H.V., Lau W.C.S. and Tsang H.L.H., Comparing Diffusion Weighted Imaging (dwi) With Clinical And Blood Parameters, And With Short Tau Inversion Recovery (stir) Sequence In Detecting Spinal And Sacroiliac (si) Joint Inflammation In Axial Spondyloarthritis (axspa), Clinical Experimental Rheumatology. 2017.

Chung H.Y., XU X., Lau W.H.V., Ho G., Lee K.L., Li P.H., Tsang H.L.H., Kwok S.K., Lau W.C.S. and Wong C.S., Comparing diffusion weighted imaging with clinical and blood parameters, and with short tau inversion recovery sequence in detecting spinal and sacroiliac joint inflammation in axial spondyloarthritis., Clin Exp Rheumatol. 2017, 35(2): 262-269.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

Researcher : Esteban MA

List of Research Outputs

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : FEI Y

List of Research Outputs

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., . Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., . Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 25th Annual Scientific Congress of the Hong Kong College of Cardiology, 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of randomized controlled trials, International Journal of Cardiology. 2016, 220: 895-900.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: network meta-analysis of randomised controlled trials. ., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016. Young Investigator Award. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal systolic blood pressure target for hypertensive patients: a network meta-analysis., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Researcher : FU SN

List of Research Outputs

FU S.N., Dao M.C., Luk W., Ho I.S.F., Lam M.C.H., Cheung S.K. and Cheung B.M.Y., Empowering patients to better blood pressure control: a qualitative study of patients’ views, practice and response to self-blood pressure monitoring (SBPM)., Presented at the Hospital Authority Convention, Hong Kong 2017.. 2017.

FU S.N., Dao M.C., Luk W., Ho S.F., Lam C.H., Cheung S.K., Wong C.K.H. and Cheung B.M.Y., Improving Quality of Home Blood Pressure Monitoring in Uncontrolled Hypertension: A Randomised Control Trial Protocol, 2016 Primary Health Care Research Conference, The National Convention Centre, Canberra from 8-9 June 2016.. 2016.

FU S.N., Yu W.C., Wong C.K.H. and Lam M.C.H., Prevalence of undiagnosed airflow obstruction among people with a history of smoking in a primary care setting, International Journal of Chronic Obstructive Pulmonary Disease. 2016, 11 (1): 2391—2399.

Researcher : Feng Z

Project Title:	30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):	Feng Z
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Researcher : Fong HY

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.H.P., Woo Y.C., Yuen M.M.A., Fong H.Y., Cheung B.M.Y. and Lam K.S.L., Obesity indices in the prediction of incident type 2 diabetes mellitus in a long- term cohort study of Hong Kong Chinese, The International Diabetes Federation World Diabetes Congressm Vancouver, Canada . 2016.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

Researcher : Fung JYY

List of Research Outputs

Chan H.L., Tsang O.T., Hui Y.T., Fung J.Y.Y., Lui G.C., Lai C.L., Wong G.L., Chan K.H., But Y.K.D., Lai M.S., Lao W.C., Chan C., Lam Y.S., Seto W.K.W., Li C., Yuen R.M.F. and Wong V.W., Real-Life Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir in Chronic Hepatitis C Patients in Hong Kong, Journal of Gastroenterology and Hepatology. 2016, 32(6): 1230-33.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of primary biliary cholangitis in Hong Kong: Results from the public healthcare system database from 2000 to 2015. [Poster presentation, Hepatology 2016; 64(S1):198A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Predictive factors of hepatocellular carcinoma and transplant-free survival in Chinese patients with primary biliary cholangitis. [Poster presentation, Hepatology 2016; 64(S1):678A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid, Clin Transl Gastroenterol. 2017, 8(6): e100.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic factors for transplant-free survival and external validation of prognostic models in Chinese patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S544.

Chok K.S.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Dai W.C. and Lo C.M., Biliary anatomy is not a contraindication for right liver donation, The 12th Academic Surgical Congress, Las Vegas, U.S.A., 7-9 February 2017.

Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Dai W.C., Cheung T.T., Sin S.L., Wong C.L.T., She W.H., Ma K.W. and Lo C.M., Comparable short and long term outcomes in deceased and living donor liver retransplantation in High MELD score patients (Oral Presentation), The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Yokohama, Japan, 7-10 June 2017.

Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Dai W.C., Cheung T.T. and Lo C.M., Liver donor liver re-transplantation: are we on the edge of the cliff? (Plenary Session 1) (Oral Presentation), Asian Transplantation Week 2016, Incheon, Korea, 27-29 October 2016.

Fung J.Y.Y., Acute kidney injury and hepatorenal syndrome in decompensated liver cirrhosis, 6th Biennial Congress of the Asia Pacific Hepatico-Pancreatico-Biliary Association (Yokohama, Japan). 2017.

Fung J.Y.Y., Current Approved Directly Acting Antivirals for Chronic Hepatitis C, Multi-speciality Medical Mega Conference 2017 (Hong Kong). 2017.

Fung J.Y.Y., HBV Therapeutic Vaccines and cccDNA Inhibitors - Emergence Of A Cure, The Liver Meeting 2017 of the American Association for the Study Of Liver Diseases - Liver Transplant Postgraduate Course (Boston, USA). 2016.

Fung J.Y.Y., Immunosuppression In Pregnancy, 20th Annual Scientific Meeting of the Malaysian Society of Transplantation (Kuala Lumpur, Malaysia). 2017.

Fung J.Y.Y., Immunosuppression Minimization - Who When and How, The Liver Transplant Symposium 2016 (Singapore). 2016.

Fung J.Y.Y., Liver transplantation for hepatocellular carcinoma - is this the best option, Malaysian Society of Gastroenterology and Hepatology Annual Scientific Congress. 2016.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Sin S.L., Ma K.W., Ng K.C.K., Ng K.C.K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Long Term Outcomes of Entecavir Monotherapy for Chronic Hepatitis B after Liver Transplantation: Results up to 8 years, Hepatology. 2017, 66(4): 1036-44.

Fung J.Y.Y., Making Sense of Pre-transplant Prognostic Scores, The Liver Transplant Symposium 2016 (Singapore). 2016.

Fung J.Y.Y., Management of Decompensated Cirrhotic Patients (without HCC), Asia Pacific Scientific Exchange - HCV in Advanced Liver Disease (Hong Kong). 2016.

Fung J.Y.Y., Managing Complications of Liver Cirrhosis and Portal Hypertension, Malaysian Society of Gastroenterology and Hepatology Annual Scientific Congress. 2016.

Fung J.Y.Y., Managing Hepatorenal Syndrome Type-1 - A Hong Kong Perspective, Malaysian Hepatorenal Syndrome Expert Panel Meeting. 2016.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Ng K.C.K., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L. and Yuen R.M.F., No increase in graft fibrosis for hepatitis B surface antigen positive patients after liver transplantation using entecavir monotherapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL). Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S184-S185.

Fung J.Y.Y., Post Transplant Hepatitis B Management, 26th International Congress of the Transplantation Society (Hong Kong). 2016.

Fung J.Y.Y., Transplant for chronic hepatitis C - when and what to treat, 20th Annual Scientific Meeting of the Malaysian Society of Transplantation. 2017.

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Li J., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver Int. 2017, 37(9): 1287-94.

Ma K.W., Chok K.S.H., Fung J.Y.Y. and Lo C.M., A body weight independent formula for estimation of standard liver volume in living donor liver transplantation, Asian Transplantation Week 2016, Incheon, Korea, 27-29 October 2016.

Ma K.W., Chok K.S.H., Chan A.C.Y., Tam S.C., Dai W.C., Cheung T.T., Fung J.Y.Y. and Lo C.M., A new formula for estimation of standard liver volume using computed tomography-measured body thickness, Liver Transplantation. 2017, 23(9): 1113-1122.

Ma K.W., Chok K.S.H., Chan A.C.Y., Fung J.Y.Y., Dai W.C., Cheung T.T. and Lo C.M., Best Abstract Award (Gold) (Abstract title: A body weight independent formula for estimation of standard liver volume in living donor liver transplantation), Asian Transplantation Week 2016, Incheon, Korea, 27-29 October 2016. 2016.

Ma K.W., Chok K.S.H., Chan A.C.Y., Cheung T.T., She W.H., Dai W.C., Fung J.Y.Y. and Lo C.M., Defining optimal surgical treatment for outside Milan hepatocellular carcinoma - a propensity score matched analysis (E-Poster), The 2017 Joint International Congress of ILTS, ELITA & LICAGE, Prague, Czech Republic, 24-27 May 2017.

Ma K.W., Chok K.S.H., Chan A.C.Y., Cheung T.T., She W.H., Dai W.C., Fung J.Y.Y. and Lo C.M., Defining optimal surgical treatment for recurrent hepatocellular carcinoma - a propensity score matched analysis (Oral Presentation), HBP Surgery Week 2017, Jeju, Korea, 31 March - 1 April 2017.

Ma K.W., Chok K.S.H., Chan A.C.Y., Cheung T.T., She W.H., Fung J.Y.Y. and Lo C.M., Defining optimal treatment for beyond criteria HCC - a propensity score matched analysis, The Liver Week 2017, Incheon, Korea, 22-24 June 2017.

Mak L.Y., Seto W.K.W., Hui R., Fung J.Y.Y., Cheung K.S., Lai C.L. and Yuen R.M.F., Nucleos(t)ide analogue decreased liver stiffness of e-antigen negative chronic hepatitis B (CHB) patients over a 10-year interval, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S251.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Fung J.Y.Y., Cheung K.S., Mak L.Y., Hui R.W.H., Liu S.H.K., Lai C.L. and Yuen R.M.F., Body-mass index is associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B., Alimentary Pharmacology and Therapeutics. 2016, 44: 1071-1079.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

She W.H., Chok K.S.H., Fung J.Y.Y., Chan A.C.Y. and Lo C.M., Outcomes of right-lobe and left-lobe living-donor liver transplantations using small-for-size grafts, World Journal of Gastroenterology. 2017, 23(23): 4270-4277.

Terrault N., Berenguer M., Strasser S.I., Gadano A., Lilly L., Samuel D., Kwo P.Y., Agarwal K., Curry M.P., Faguioli S., Fung J.Y.Y., Gane E., Brown K.A., Burra P., Charlton M., Pessoa M.G. and McCaughan G.W., International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Recipients, Transplantation. 2017, 101: 956-967.

Terrault N.A., McCaughan G.W., Curry M.P., Gane E., Fagiuoli S., Fung J.Y.Y., Agarwal K., Lilly L., Strasser S.I., Brown K.A., Gadano A., Kwo P.Y., Burra P., Samuel D., Charlton M., Pessoa M.G. and Berenguer M., International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Candidates, Transplantation. 2017, 101: 945-955.

Wong C.L.T., Ng K.C.K., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C. and Lo C.M., Avoiding futility: outcomes of liver transplantation in critically ill patients over 2 decades. , 2017 Joint International Congress of ILTS, ELITA & LICAGE. 2017.

Wong C.L.T., Lo C.M. and Fung J.Y.Y., Emerging drugs for prevention of T-cell mediated rejection in liver and kidney transplantation, Expert Opinion on Emerging Drugs. 2017, 1-14.

Wong C.L.T., Fung J.Y.Y., Chan S.C. and Lo C.M., Hepatitis B vaccination in patients receiving antiviral monotherapy after liver transplantation for chronic hepatitis B, The 26th International Congress of The Transplantation Society, Hong Kong, 18-23 August 2016.

Wong C.L.T., Fung J.Y.Y., Chok K.S.H., Chan A.C.Y. and Lo C.M., Similar donor and recipient outcomes after left lobe and right lobe living donor liver transplantation, The Liver Meeting 2016, Boston, U.S.A., 11-15 November 2016.

Wong C.L.T., Fung J.Y.Y., Chan S.C. and Lo C.M., The use of hepatitis B core antibody positive donors for liver transplantation does not lead to inferior survival, The 26th International Congress of The Transplantation Society, Hong Kong, 18-23 August 2016.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Yap Y.H.D., Seto W.K.W., Fung J.Y.Y., Chok K.S.H., Chan S.C., Chan G.C.W., Yuen R.M.F. and Chan T.M., Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis, Digestive and Liver Disease. 2016, 49(2): 202-206.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Fung TK

List of Research Outputs

BAI Y., Wong K.Y., Fung T.K. and Chim J.C.S., High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes, Journal of Hematology & Oncology. 2016.

Researcher : GENG L

List of Research Outputs

GENG L., LIAO B., JIN L., HUANG Z., Woo W.H.C., Lam K.S.L. and Xu A., Chronic exercise alleviated dietary obesity-associated metabolic dysfunction by enhancing FGF-21 sensitivity in adipose tissues., The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Researcher : Gao F

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Gao Y

List of Research Outputs

Gao Y., Cheung R.T., Gao J., Lau E.Y.Y., WAN J.H.Y. and Mok M.Y., Electrophysiological study on cognitive function in systemic lupus erythematosus patients with previous neuropsychiatric involvement, Clinical EEG & Neuroscience. 2016, 21.

Hui X., Gao Y., Wang Y. and Xu A., Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, EMBO reports. 2017, 18: 645-657.

Researcher : Gao Y

List of Research Outputs

Hui X., Gao Y., Wang Y. and Xu A., Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, EMBO reports. 2017, 18: 645-657.

Researcher : Gu P

List of Research Outputs

Hui X., Gu P., Zhang J., Wang Y. and Xu A., 2016 Research Output Award, The University of Hong Kong. 2016.

Nie B.M., Nie T., Hui X., Gu P., Mao L.F., Li K., Yuan R., Zheng J., Xu A., Wu D. and Ding S., Brown adipogenic reprogramming induced by a small molecule, Cell reports. 2017, 18: 624.

Researcher : HO SK

List of Research Outputs

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Researcher : HO SK

List of Research Outputs

Researcher : HUANG Z

List of Research Outputs

GENG L., LIAO B., JIN L., HUANG Z., Woo W.H.C., Lam K.S.L. and Xu A., Chronic exercise alleviated dietary obesity-associated metabolic dysfunction by enhancing FGF-21 sensitivity in adipose tissues., The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Huang Z., Xu A. and Cheung B.M.Y., The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension, Current Hypertension Reports. 2017, 19.

Researcher : Ha CTJ

List of Research Outputs

Chen L.P., Fan Y., Kao P.Y., Ho D.T., Ha C.T.J., Chu L.W. and Song Y., Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimer's Disease: Evidence from a Southern Chinese Population, J Am Geriatr Soc.. 2017, 65(2): 332-339.

Researcher : Hai SHJJ

Project Title:	Effect of a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist on Hypertension-Induced Atrial Remodelling
Investigator(s):	Hai SHJJ, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Hai S.H.J.J., Cardiac Resynchronization Therapy Overview, Clinical Overview of Cardiac Devices Therapy, Hong Kong Cardiac Nursing Association Ltd cum Hong Kong College of Cardiac Nursing Ltd. 2016.

Hai S.H.J.J., Eligibility And Disqualification Recommendations For Athletes – How Should Cardiologists Advise The Patients?, Cardiorhythm 2017. 2017.

Hai S.H.J.J. and Tse H.F., Freezing for the future: Next generation of cryoballoon for the treatment of atrial fibrillation., Heart Rhythm. 2016.

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Hai S.H.J.J., Wong C.K., Chan P.H.M., Tse H.F., Yung T.C. and Siu D.C.W., Quinidine for Brugada syndrome: Panacea or poison?, HeartRhythm Case Rep.. 2016, 2(6): 486-490.

Hai S.H.J.J., SICD in an Asian Population, The 19th South China International Congress of Cardiology. 2017.

Hai S.H.J.J., Sudden Cardiac Death and Ventricular Arrhythmias after ACS, Cardiorhythm 2017. 2017.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Researcher : He BA

Project Title:	ISEH for the 45th Annual Scientific Meeting; Follistatin is a critical mediator for FLT3/ITD+ acute myeloid leukemia
Investigator(s):	He BA
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

List of Research Outputs

He B.A., Dr KP Stephen Chang Gold Medal, The University of Hong Kong. 2016.

He B.A., LAM S.Y., CHER C.Y., NG K.L. and Leung A.Y.H., Follistatin is a critical mediator for FLT3/ITD+ acute myeloid leukemia, Experimental Hematology. 2016, 44: S79.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : Ho AYY

List of Research Outputs

Luk A.O.Y., Hui E.M.T., Sin M.C., Yeung C.Y., Chow W.S., Ho A.Y.Y., Hung H.F., Kan E., Ng C.M., So W.Y., Yeung C.K., Chan K.S., Chan K.W., Chan P.F., Siu S.C., Tiu S.C., Yeung T.F., Chan J.C.N., Chan F.W.K., Chan C., Cheung N.T., Ho S.T., Lam K.S.L., Yu L.W.L., Chao D. and Lau I.T., Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database, Diabetes Care. 2017, 40: 928-935.

Researcher : Ho JCM

Project Title:	MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:	07/2005

Project Title:	A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):	Ho JCM, Wong KYM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	02/2007

Project Title:	A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2007

Project Title:	The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Lee Wing Tat Fund
Start Date:	08/2007

Project Title:	A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	11/2007

Project Title:	A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	06/2008

Project Title:	A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	12/2008

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Hong Kong Lung Foundation Research Grant
Start Date:	02/2009

Project Title:	A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):	Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2009

Project Title:	Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2010

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	03/2011

Project Title:	A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2011

Project Title:	Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	05/2011

Project Title:	In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):	Ho JCM, Lam SK
Department:	Medicine
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2011

Project Title:	A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):	Ho JCM, Lam CLD
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	02/2012

Project Title:	In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma
Investigator(s):	Ho JCM, Lam SK
Department:	Medicine
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2015

List of Research Outputs

David-Wang A., Price D., Cho S.H., Ho J.C.M., Liam C.K., Neira G., Teh P.L. and REcongise Ashtma and Link to Symptoms and Experience (RELEASE) Asia Working Group .., Development and Validation of an Attitudinal-Profiling Tool for Patients With Asthma, Allergy, Asthma & Immunology Research. 2017, 9(1): 43-51.

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Ho J.C.M. and Lam S.K., Combination of Arginine Depletion and Chemotherapy in Thoracic Malignancies, Journal of Clinical Oncology. 2017, 35(16): 1758-1759.

Ho J.C.M., Editorial Board Member since March 2017, Tuberculosis and Respiratory Diseases (official journal of Korean Academy of Tuberculosis and Respiratory Diseases). 2017.

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. WCLC 2016, Vienna (Abstract ID 4859)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna Austria. 2016.

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Suppression of tumour growth by pegylated arginase in malignant pleural mesothelioma. WCLC 2016, Vienna (Abstract ID 4854)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Kwok W.C., Tam C.C.T., Lui M.S.M., Lam C.L.D. and Ho J.C.M., Control of brain metastases with alectinib in anaplastic lymphoma kinase-rearranged lung cancer, Respirology Case Reports. 2017, 5(3): e00224.

Lam C.L.D., Ho J.C.M. and Ip M.S.M., Respiratory medicine: Short Cases, Problem Based Medical Case Management, Second Edition. Hong Kong, Hong Kong University Press, 2016, 178-194.

Lam S.K., LEUNG L.L., Li Y.V., Zheng C. and Ho J.C.M., Combination effects of arsenic trioxide and fibroblast growth factorreceptor inhibitor in squamous cell lung carcinoma, Lung Cancer. 2016, 101: 111-119.

Lam S.K., Li Y.V., XU S., LEUNG L.L., U K.P., ZHENG Y.F., CHENG P.N. and Ho J.C.M., Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts, Respiratory Research. 2017, 18(1): 80.

Lam S.K., XU S. and Ho J.C.M., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, 22nd Medical Research Conference. 2017, 23: 26.

Price D., David-Wang A., Cho S.H., Ho J.C.M., Jeong J.W., Liam C.K., Lin J., Muttalif A.R., Perng D.W., Tan T.L., Yunus F. and Neira G., Asthma in Asia: Physician perspectives on control, inhaler use and patient communications, Journal of Asthma. 2016, 53(7): 761-769.

Wu J., Zeng R., Huang J., Li X., Zhang J., Ho J.C.M. and Zheng Y., Dietary Protein Sources and Incidence of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Studies, Nutrients. 2016, 8(11): pii:E730.

XU S., Lam S.K., Cheng P.N. and Ho J.C.M., In vitro effects of pegylated arginase in small cell lung cancer. WCLC 2016, Vienna (Abstract ID 4163)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Researcher : Ho SL

Project Title:	Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):	Ho SL, Song Y, Wang Y
Department:	Medicine
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	04/2007

Project Title:	Pathophysiological study of Parkinson's disease associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation
Investigator(s):	Ho SL, Ho WL, Siu DCW
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	12/2016

List of Research Outputs

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Ito G., Katsemonova K., Tonelli F., Lis P., Baptista M.A.S., Shpiro N., Duddy G., Wilson S., Ho W.L., Ho S.L., Reith A.D. and Alessi D.R., Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors, Biochemical Journal. 2016, 473: 2671-2685.

Lau G.K.K., Li L., Schulz U., Simoni S., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke – validation in two large cohorts, 3rd European Stroke Organisation Conference. 2017.

Lau G.K.K., Li L., Schulz U., Simoni M., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke: validation in 2 large cohorts, Neurology. 2017, 88: 2260-2267.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Liu H., Ho W.L., Tse H.M., Pang S.Y.Y., Ramsden D.B. and Ho S.L., Leucine-rich Repeat Kinase 2 (lrrk2) Knockin Mouse Model For Pathophysiological Studies Of Parkinson's Disease (pd), Health Research Symposium 2017 (Food and Health Bureau, Hong Kong S.A.R.). 2017.

Teo K.C., Lee C.Y., Chang S.K.R., Ho S.L. and Chan K.H., Aetiology, clinical presentation, and outcome of encephalitis in Hong Kong, 22nd Medical Research Conference. 2017, 23: 42.

Researcher : Ho WL

Project Title:	Neurotoxic effects of environmental estrogenic endocrine disruptive compounds on brain dopamine homeostasis
Investigator(s):	Ho WL, Ho SL, Leung KMY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

List of Research Outputs

Ho W.L., Editorial Board Member, In: Prof. Osman Sinanovic (Editor-in-chief), BAOJ Neurology. 2017.

Ho W.L., Editorial Board Member, Scientific Reports. 2017.

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Ito G., Katsemonova K., Tonelli F., Lis P., Baptista M.A.S., Shpiro N., Duddy G., Wilson S., Ho W.L., Ho S.L., Reith A.D. and Alessi D.R., Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors, Biochemical Journal. 2016, 473: 2671-2685.

Kukalev A., NG Y.M., JU L., Saidi A., Lane S., Mondragon A., Dormann D., Walker S.E., Grey W., Ho W.L., Stephens D.N., Carr A.N., Kamsa K., Tse E.W.C. and YU V.P., Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates, Cerebral Cortex. 2017, 27: 11-23.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Liu H., Ho W.L., Tse H.M., Pang S.Y.Y., Ramsden D.B. and Ho S.L., Leucine-rich Repeat Kinase 2 (lrrk2) Knockin Mouse Model For Pathophysiological Studies Of Parkinson's Disease (pd), Health Research Symposium 2017 (Food and Health Bureau, Hong Kong S.A.R.). 2017.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Researcher : Hong X

List of Research Outputs

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Hoo RLC

Project Title:	The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation
Investigator(s):	Hoo RLC, Zhang J
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Adipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity
Investigator(s):	Hoo RLC, Xia Z, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Deciphering the role of lipid chaperone fatty acid binding protein 4 in the development of obesity-induced diabetic nephropathy
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015
Completion Date:	03/2017

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of ischemic stroke associating with obesity
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction.
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of KSSO; Adipocyte Fatty Acid Binding Protein (A-FABP) Modulates Adaptive Thermogenesis by Promoting Intracellular Activation of Thyroid Hormones in Brown Adipocytes
Investigator(s):	Hoo RLC
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2016
Completion Date:	09/2016

Project Title:	The role of lipid chaperone ap2 in regional adipose tissue expandability
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

Hoo R.L.C., Travel Grant Award, Korean Society for the Study of Obesity - KSSO. 2016.

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein (A-FABP) in obesity and its related complications: Friend or Foe?, 4th Lingnan International Symposium of Metabolic Diseases: Frontiers in Immunometabolism. 2017.

WU X., Shu L., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of liver fibrosis, FASEB Science Research Conference. 2017.

Zhou M., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP)is a potential mediator of heart dysfunction and failure related to obesity, the 11th International Diabetes Federation Western Pacific Region Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes in Taipei, Taiwan . 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Vanhoutte P.M.G.R., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clinical Science. 2016.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Hu HC, Lam CLK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1998

Researcher : Huang D

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Researcher : Huang FY

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Ye W., Takabayashi H., Yang Y.T., Mao M.Y., Samuelson L.C., Demitrack E., Huang F.Y., Chu K.M., Leung W.K. and Todisco A., Regulation of CD44 expression by bone morphogenetic protein (BMP) signaling and inflammatory stimuli, Digestive Disease Week (DDW) 2017. Gastroenterology, 152: Gastroenterology. 2017;152(5)S86.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Huang Z

List of Research Outputs

Huang Z., Xu A. and Cheung B.M.Y., The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension, Current Hypertension Reports. 2017, 19.

Researcher : Hui CK

Project Title:	Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):	Hui CK, Liang RHS, Lau G, Lie AKW
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Hui KMC

List of Research Outputs

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Hui K.M.C., The impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function, Respiration: International review of thoracic diseases. 2016, 91: 124-31.

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and cardiovascular events in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

Researcher : Hui X

Project Title:	SIRT1 in perivascular adipose tissues(PVAT) as a mediator of obesity-induced endothelial dysfunction by controlling brown-to-white transition of PVAT: Molecular mechanisms and therapeutic interventions
Investigator(s):	Hui X, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Mechanisms of Metabolic Signaling; MiR-34a triggers adipose inflammation and metabolic dysfunction in obesity by blocking M2 macrophage polarization and proliferation
Investigator(s):	Hui X
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

Project Title:	The non-canonical thermoregulatory pathways in uncoupling protein-1 (UCP1) independent manner
Investigator(s):	Hui X, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Hui X., Gu P., Zhang J., Wang Y. and Xu A., 2016 Research Output Award, The University of Hong Kong. 2016.

Hui X., Gao Y., Wang Y. and Xu A., Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, EMBO reports. 2017, 18: 645-657.

Mao L., Nie B., Nie T., Hui X., Gao X., Lin X., Liu X., Xu Y., Tang X., Yuan R., Li K., Li P., Ding K., Wang Y., Xu A., Fei J., Han W., Liu P., Madsen L., Kristansen K., Zhou Z., Deng S. and Wu D., Visualization and Quantification of Browning Using a Ucp1 -2A-Luciferase Knock-in Mouse Model , Diabetes. 2017, 66: 407-417.

Nie B.M., Nie T., Hui X., Gu P., Mao L.F., Li K., Yuan R., Zheng J., Xu A., Wu D. and Ding S., Brown adipogenic reprogramming induced by a small molecule, Cell reports. 2017, 18: 624.

Nie T., Hui X., Mao L., Nie B.M., Li K. and Sun W., Harmine induces adipocyte thermogenesis through RAC1-MEK-ERK-CHD4 axis., Scientific reports. 2016, 6: 36382.

Researcher : Hui YLE

Project Title:	Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes
Investigator(s):	Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2013

List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Researcher : Hung FNI

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Efficacy of combined influenza and 23-valent polysaccharide pneumococcal vaccines in patients with chronic illness (Project No. HK-09-01-16), Health Research Symposium 2017, The Food and Health Bureau of the Hong Kong SAR Government. 2017.

Hung F.N.I., HIV and intestinal co-infection, Asia Pacific AIDS & Co-infections Conference 2017 on 2 June 2017. 2017.

Hung F.N.I. and Yuen K.Y., Immunogenicity, safety and tolerability of intradermal influenza vaccines, Human Vaccines & Immunotherapeutics. 2017, 1-6.

Hung F.N.I., Indications of pneumococcal vaccination in adult - what guidelines recommend, Medical and Paediatric Infectious Disease Week 2017, Infectious Disease Control Training Centre, Hospital Authority; Hospital Authority Infectious Disease Centre, Princess Margaret Hospital. 2017.

Hung F.N.I., The Skin as The Mastermind Behind Influenza Immunity, Richard Yu Lecture 2016, Hong Kong College of Physicians Annual Scientific Meeting, 16 October 2016. 2016.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Ko M.K.L., Ng S.C., Mak L.Y., Li M.K., Lo F.H., Ng C.K.M., Lao W.C., Tsang S., Chan K.H., Hui Y.T., Shan E.H.S., Loo C.K., Hui A.J., To W.P., Hung F.N.I. and Leung W.K., Infection-related Hospitalizations Within The First Year After IBD Diagnosis, Journal of Digestive Diseases. 2016, 17(9): 610-617.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Leung W.K., But Y.K.D., Wong S.Y., Liu S.H.K. and Hung F.N.I., Prevention of Post-sphincterotomy Bleeding by Proton Pump Inhibitor: A Prospective Randomized Trial, 25th United European Gastroenterology Week, 15-19 Oct 2016, Vienna, Austria. 2016.

Li X., Chan N.S., Tam A.W., Hung F.N.I. and Chan E.W., Budget impact and cost-effectiveness analyses of direct-acting antivirals for chronic hepatitis C virus infection in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2017.

Lung D.C., Tsang O.T.Y., Choi K.W., Hung F.N.I., Chan K.M., WU A.K.L., Tso E.Y.K., Wu T.C., Lam T.S., Wong A.W.Y., Ng K.H.L., Lui S.S.Y., Hsu E.K. and Wong A.T.Y., Review of first 36 cases of New Delhi metallo-β-lactamase–producing Enterobacteriaceae in Hong Kong, Journal of Global Antimicrobial Resistance. 2017, 8: 199-201.

Mak L.Y., Ng S.C., Wong O.L., Li M.K.K., Lo F.H., Wong M.T.L., Leung C.M., Tsang S.W.C., Chan K.H., Sze S.F., Shan E.H.S., Lam E.H.S., Hui A.J., Hung F.N.I. and Leung W.K., Direct Health Care Cost Utilization in Hong Kong Inflammatory Bowel Disease Patients in the Initial 2 Years Following Diagnosis, Journal of Gastroenterology and Hepatology. 2017.

Ng S.C., Leung W.K., Shi H.Y., Li M.K.K., Leung C.M., Ng C.K.M., Lo F.H., Hui Y.T., Tsang S.W.C., Chan Y.K., Loo C.K., Chan K.H., Hui A.J., Chow W.H., Harbord M., Ching J.Y.L., Lee M., Chan V., Tang W., Hung F.N.I., Ho J.W.C., Lao W.C., Wong M.T.L., Sze S.F., Shan E.H.S., Lam B.C.Y., Tong R.W.H., Mak L.Y., Wong S.H., Wu J.C.Y., Chan F.K.L. and Sung J.J.Y., Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong., Inflammatory Bowel Diseases. 2016, 22(8): 1954-1960.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Shi H.Y., Chan F.K.L., Leung W.K., Li M.K.K., Leung C.M., Sze S.F., Ching J.Y., Lo F.H., Tsang S.W., Shan E.H.S., Mak L.Y., Lam B.C.Y., Hui W.H., Chow W.H., Wong M.T.L., Hung F.N.I., Jui Y.T., Chan Y.K., Chan K.H., Loo C.K., Ng C.K.M., Lao W.C., Harbord M., Wu J.C.Y., Sung J.J.Y. and Ng S.C., Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry, Therapeutic Advances in Gastroenterology. 2016, 9(4): 449-456.

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

To K.K.W., Lu L., Hung F.N.I. and Yuen K.Y., Host response of rhinovirus infection among hospitalized adult patients, American Society for Virology 36th Annual Meeting. 2017.

Researcher : Hung I.F.N.

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Researcher : Hung IFN

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Researcher : Hwang YYG

List of Research Outputs

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Researcher : Ip MSM

Project Title:	The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):	Ip MSM
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1997

Project Title:	The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):	Ip MSM, Peh WCG, Cooke MS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Ip MSM, Lam KSL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):	Ip MSM, Lam KSL, Song Y, Sham PC
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

List of Research Outputs

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Best Oral Presentation Award on Basic Science, 22nd Medical Research Conference (MRC), HKU. Hong Kong, Hong Kong Academy of Medicine Press, 2017, 23 (Supplement 1): 17.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Cigarette smoke medium induces apoptosis via the translocator protein (TSPO) in airway epithelial cells, American Thoracic Society (ATS) International Conference 2017, Am J Respir Crit Care Med . USA, ATS, 2017, 195: A6297.

CUI Y., Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells, Toxicology Letters. 2017, 268: 44-50.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Selegeline suppressed cigarette smoke medium (CSM)-induced oxidative stress, inflammation and apoptosis via monoamine oxidase-B inhibition in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 17.

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Ip M.S.M. and Wong D., OSA and Diabetic Mellitus – SEEING Beyond Glycemic Control , American Journal of Respiratory and Critical Care Medicine. 2017.

Ip M.S.M. and Lee G.Y.C., Book Editorship, Respiratory section. Problem Based Medical Case Management Book, 2nd Edition. Hong Kong University Press 2017. 2017.

Ip M.S.M., Chairman, Advanced Course on Sleep and Breathing Symposium (VI), Hong Kong Thoracic Society & CHEST Delegation Hong Kong & Macau, Hong Kong, Mar 2017. 2017.

Ip M.S.M., Chairman, Interactive Grant Round in Respiratory Medicine Session, Hong Kong Thoracic Society & CHEST Delegation Hong Kong & Macau Annual Scientific Meeting, Mar 2017. 2017.

Ip M.S.M., Co-chairman, Richard Yu Lecture, 22nd Hong Kong Medical Forum, Hong Kong, May 2017. 2017.

Ip M.S.M., Invited lecture - Cardiometabolic aspects and other conditions associated with OSA, Hong Kong Thoracic Society & CHEST Delegation Hong Kong & Macau, Hong Kong, Mar 2017. 2017.

Ip M.S.M., Invited lecture - Health risks of obstructive sleep apnea, Hospital Authority Convention, Hong Kong, May 2017. 2017.

Ip M.S.M., Invited lecture - Sleep apnea and diabetes mellitus: a complex relationship (Postgraduate Course), European Respiratory Society International Congress 2016, London, UK. 2016.

Ip M.S.M., Invited lecture - The GOLD Global Strategy for COPD 2016 - Highlights for pulmonologists and non-pulmonologists, 4th Medical Forum of University of Hong Kong-Shenzhen Hospital, Shenzhen, China, Nov 2016. 2016.

Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2017.

Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2017.

Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2016.

Ip M.S.M., Member of Editorial Board, Sleep Medicine Research of Korean Society of Sleep Medicine. 2017.

Ip M.S.M., Obstructive sleep apnea and metabolic disorders, In: Kryger MH, Roth T, Dement WC, Principlies and Practice of Sleep Medicine, 6th Edition. Elsevier Inc, 2017, Chapter 118: 1167-1178.

Ip M.S.M., Invited lecture - 重症肺炎的抗生素選擇, "呼吸危重病及疑難病診治"學習班(國家級繼續教育項目), Shenzhen, China, Nov 2016, 2016.

Kwok W.C., Lam S.H., Wong M.P., Ip M.S.M. and Lam C.L.D., Influenza B/Streptococcal co-infection complicated by organizing pneumonia, Respirology Case Reports. 2016, 4(5): e00170.

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Lai Y.K.A., Fong D.Y.T., Lam C.M.J. and Ip M.S.M., Long-term efficacy of an education programme in improving adherence with continuous positive airway pressure treatment for obstructive sleep apnoea, Hong Kong Medical Journal. 2017, 23(Suppl 2): S24-27.

Lam C.L.D., Ho J.C.M. and Ip M.S.M., Respiratory medicine: Short Cases, Problem Based Medical Case Management, Second Edition. Hong Kong, Hong Kong University Press, 2016, 178-194.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Leung T.H.S., Ngai C.Y.V., Chan H.Y.F., Chui C.M.W., Ip M.S.M., Wang K.L.J., Ho K.Y.C., Mo S.L.S. and Poon K.H.H., Pilot program for improving drug adherence and minimizing drug wastage in patients with asthma or chronic obstructive pulmonary disease (COPD), Hospital Authority Convention, May 2017. Abstract.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Differential inflammatory responses resulted from cellular senescence induced by doxorubicin and antimycin in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J . Hong Kong, HK Academy of Medicine Press, 2017, 23: 33.

WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-intensity intermittent hypoxia promotes subcutaneous adipogenic differentiation, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 44.

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and cardiovascular events in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

Researcher : Ip TP

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Researcher : JIAN M

List of Research Outputs

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Researcher : Jiang Y

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Jin Y, Kwong YL, Tsao GSW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2002

Researcher : KWOK HM

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

KWOK H.M. and Lam K.S.L., Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis, Endocrinology and Metabolism (Seoul). 2017, 32: 145.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Researcher : Kam KM

List of Research Outputs

Yung S.S.Y., Chu J.Y.S., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells, ASN Kidney Week 2016.

Researcher : Kho CSB

List of Research Outputs

Singh G.H.H., Ip H.W., Yip S.F., Kho C.S.B., Lee K.K.H., Mak V., Lau J.S.M., Lau C.K., Lin S.Y., Wong S.M.R., Wa L.I. and Kwong Y.L., Clofarabine, Cytarabine And Mitoxantrone (CLAM) for relapsed or refractory acute myeloid leukaemia - interim results of a prospective phase 2 study, 22nd Congress of the European Haematology Association. 2017.

Researcher : Kong SL

List of Research Outputs

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Researcher : Kopaniszen M

List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Researcher : Kumana CR

List of Research Outputs

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., . Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 25th Annual Scientific Congress of the Hong Kong College of Cardiology, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Kumana C.R. and Cheung B.M.Y., Empagliflozin therapy for type 2 diabetes: viewing possible benefits in relative and absolute terms. ., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.

Researcher : Kung AWC

Project Title:	Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):	Kung AWC, McGhee S
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	10/2009

List of Research Outputs

Cheung C.L., Leung Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C. and Tan K.C.B., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese., American Society for Bone and Mineral Research Annual Meeting, Atlanta, Sept 2016.. 2016.

LEUNG Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C., Tan K.C.B. and Cheung C.L., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese, Bone. 2017, 97: 293-298.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese, Thrombosis and Haemostasis. 2016, 117: 158-163.

Researcher : Kung MHW

List of Research Outputs

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Researcher : Kwan PYL

List of Research Outputs

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Kwan SC

List of Research Outputs

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Researcher : Kwan SKJ

Project Title:	HKU Overseas Fellowship Awards 2016-17
Investigator(s):	Kwan SKJ
Department:	Medicine
Source(s) of Funding:	HKU Overseas Fellowship Awards
Start Date:	06/2016

Project Title:	Effects of regular physical activity on immunosenescence: the role of autophagy and apoptosis on senescent T-lymphocytes and NK cells
Investigator(s):	Kwan SKJ, Wong GTC, Tse MA, Tipoe GL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

List of Research Outputs

CHEN X., Zheng C., Wu C.H. and Kwan S.K.J., Oral treatment with herbal formula B307 alleviates skeletal muscle atrophy from hind-limb unloading, 22nd Medical Research Conference. 2017.

CHEN X. and Kwan S.K.J., Systematic review of the evaluation paradigms used to assess behavior in zebrafish models of neurodegenerative diseases, 12th International Symposium on Healthy Aging. 2017.

Chiu P.W., YANG C., Har A., Mak H.K.F. and Kwan S.K.J., Magnetic resonance spectroscopy demonstrates neuronal loss and altered glutamatergic neurotransmission in Alzheimer's Disease, 22nd Medical Research Conference (HKU). 2017.

David D. and Kwan S.K.J., UCL Global Engagement Fund (Collaborator, £2000), University College London. 2016.

Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan S.K.J., Chiu K.C.P. and Lam L.C.W., Associations between neuropsychiatric symptoms, cognitive function, and daily functioning in elderly with early dementia, 38th Annual Meeting & Scientific Sessions. San Diego, California, Society of Behavioral Medicine, 2017.

Kwan R., Leung A.Y.M., Kwan C.W., Bai X., Liu J., Kwan S.K.J., Chong A. and Chi I., Factors associated with cognitive decline of the residents in Hong Kong residential care homes: A secondary data analysis of a longitudinal study, International Alzheimer's Disease Conference 2017.

Kwan S.K.J., Advances in the Diagnosis and Management of Delirium in Hospital, Central Commissioned Training Programme: “Best Practice in Ortho-geriatrics”. 2016.

Kwan S.K.J., Myint P.K., Wong A., Mok V., Lau G.K.K. and Mak H.K.F., Antithrombotic Therapy To Prevent Cognitive Decline In People With Small Vessel Disease On Neuroimaging But Without Dementia (Protocol), Cochrane Database Of Systematic Reviews. 2016, Issue 7.

Kwan S.K.J., Myint P.K., Wong A., Mok V., Lau G.K.K. and Mak H.K.F., Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementa (Protocol). , Cochrane Database of Systematic Reviews 2016, Issue 7. Art. No.: CD012269. 2016 The Cochrane Collaboration. . John Wiley & Sons, Ltd., 2016.

Kwan S.K.J., Atrial fibrillation and oral anticoagulant therapy in older people, 13th International Symposium on Healthy Aging. 2017.

Kwan S.K.J., Wong G.T.C. and Tse M.A., Benefit to the older people who train and work as exercise coaches (PI, $50K), Queen Mary Hospital Training & Research Assistance Scheme. 2017.

Kwan S.K.J., Engaging the community to improve the well-being for the older generations of the future 與社區同行提升長者生活質素, HKEC Symposium on Community Engagement XII. 2017.

Kwan S.K.J., Enhanced Recovery After Surgery For Elderly Patients, First Hong Kong Evidence Based Peri-Operative Medicine Symposium: EBPOM 2017. 2017.

Kwan S.K.J., Mak V., Hui R., Ng B., So K., Kai G. and Mak H.K.F., Impact Of White Matter Hyperintensities, Cerebral Microbleeds And Medial Temporal Lobe Atrophy On Short And Long-term Rehabilitation Outcomes After Stroke, 3rd European Stroke Organization Conference (ESOC 2017). 2017.

Kwan S.K.J., Non-invasive Brain Stimulation: A New Weapon in the AD Armory, International Alzheimer's Disease Conference 2017. 2017.

Kwan S.K.J., Optimizing AF Treatment for High Risk People: Real-life Lessons from Hospital Clinics, Annual Scientific Congress of Hong Kong College of Cardiology. 2017.

Kwan S.K.J., Psychological problems in older persons, Post-registration Certificate Course in Gerontological Nursing. 2016.

Kwan S.K.J., Seed Funding: "Effects of exercise on aging" ($56K), The University of Hong Kong. 2017.

Kwan S.K.J., Subjective cognitive decline: differentiating pathological from normal brain aging, BRAIN 2017. 2017.

Lam K.U.E.N., Leung M.F., Kwan C.W. and Kwan S.K.J., Severe Spastic Contractures and Diabetes Mellitus Independently Predict Subsequent Minimal Trauma Fractures Among Long-Term Care Residents, Journal of the American Medical Directors Association. 2016, 17: 1025-1030.

Lau H.P., Kwan S.K.J., Cheung K.S.L. and Martin P., Depression Moderates the Frailty–Subjective Health Link among Chinese Near Centenarians and Centenarians, The American Journal of Geriatric Psychiatry. 2016, 24: 753-761.

Leung D.Y.P., Kwan S.K.J., Chiu P., Chan F.H.W. and Yau S., Video-supported nurse-led advance care planning in frail geriatric patients (Co-A, $936K), RGC GRF. 2017.

Tse G., Yeo J.M., Tse V., Kwan S.K.J. and Sun B., Gap junction inhibition by heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in Langendorff-perfused mouse hearts., Molecular Medicine Report. 2016, 14: 4069-4074.

Vassallo M., Poynter L., Kwan S.K.J. and Allen S.C., A comparative study of the use of three cognitive function screening tests on rehabilitation wards for older people, European Geriatric Medicine. 2016.

Vassallo M., Poynter L., Kwan S.K.J., Sharma J.C. and Allen S.C., A prospective observational study of outcomes from rehabilitation of elderly patients with moderate to severe cognitive impairment, Clinical Rehabilitation. 2016, 30: 901-908.

Wong G.H.Y., Lum T.Y.S., Kwan S.K.J., Chan W.C., Cheung C.Y.A., Lou V.W. and Tang Y.M.J., Evaluation Study of Service for Dementia Community Support Scheme (Co-I, $1.4M), Food & Health Bureau. 2017.

XU X., Kwan S.K.J., Mak H.K.F., Wong A., Mok V.C.T. and Hui S.K., Altered white matter structural brain network in patients with subjective cognitive decline and mild cognitive impairment, European Society for Magnetic Resonance in Medicine and Biology. 2017.

XU X., Hui S.K., Mak H.K.F. and Kwan S.K.J., Identifying the earliest sign of pathological cognitive decline by using magnetic resonance imaging structural brain connectivity analysis, 22nd Medical Research Conference. 2017.

YANG C., Wong G.T.C. and Kwan S.K.J., Event related potential during prospective memory task may predict cognitive function in subjective cognitive decline, 12th International Symposium on Healthy Aging. 2017.

YANG C., LI J., Wong G.T.C. and Kwan S.K.J., Event-related potential using task-based electroencephalogram may differentiate between mild cognitive impairment and normal controls, 22nd Medical Research Conference (HKU). 2017.

YANG C., Wong G.T.C. and Kwan S.K.J., The behavioral performance and event-related potential components of the go/no-go task from healthy elders to mild cognitive impairment, 12th International Symposium on Healthy Aging. 2017.

Yeo J.M., Tse V., Kung J., Lin H.Y., Lee Y.T., Kwan S.K.J., Yan B.P. and Tse G., Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances, Journal of Basic and Clinical Physiology and Pharmacology. 2017, 0.

ZHANG H., Kwan S.K.J., Chiu P.W., Hui S.K., Chan Q. and Mak H.K.F., Altered Hippocampal Functional Connectivity with PCC in SCI, MCI and AD, The 25th Annual Meeting of ISMRM, Honolulu, Hawaii, USA. 2017. 2360.

Researcher : Kwok HM

List of Research Outputs

KWOK H.M. and Lam K.S.L., Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis, Endocrinology and Metabolism (Seoul). 2017, 32: 145.

Researcher : Kwong YL

Project Title:	Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):	Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Molecular basis of arsenic resistance in tumours
Investigator(s):	Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):	Kwong YL, Liang RHS, Lie AKW, Au WY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2004

Project Title:	Provision of ibritumomab for the treatment of lymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):	Kwong YL, Au WY, Chim JCS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	05/2010

Project Title:	Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):	Kwong YL, Leung AYH, Tse EWC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia
Investigator(s):	Kwong YL, Leung AYH, Tse EWC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Provision of free azacitidine for high-risk patient with myelodysplastic syndrome (MDS)
Investigator(s):	Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2014

Project Title:	Plasma DNA as a Platform Technology for Cancer Detection
Investigator(s):	Kwong YL
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2016

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

Chan S.Y., Au Yeung K.H.R., Chim J.C.S., Wong C.Y. and Kwong Y.L., Disseminated fusarium infection after ibrutinib therapy in chronic lymphocytic leukaemia, Annals of Hematology. 2017, 96: 871-872.

Chan S.Y.T., Tse E.W.C. and Kwong Y.L., Chidamide in the treatment of peripheral T-cell lymphoma, OncoTargets and Therapy. 2017, Volume 10: 347-352.

Chan S.Y.T., Luk T.H., Lau J.S., Khong P.L. and Kwong Y.L., Low-dose pembrolizumab for relapsed/refractory Hodgkin lymphoma: high efficacy with minimal toxicity, Annals of Hematology. 2017, 96: 647-651.

Chan S.Y.T., Khong P.L. and Kwong Y.L., Pembrolizumab and lenalidomide induced remission in refractory double-hit lymphoma, Annals of Hematology. 2016.

Chan S.Y.T., Khong P.L. and Kwong Y.L., Pembrolizumab for relapsed anaplastic large cell lymphoma after allogeneic haematopoietic stem cell transplantation: efficacy and safety, Annals of Hematology. 2016.

Chan S.Y.T., Lee E.Y.P., Khong P.L., Tse E.W.C. and Kwong Y.L., Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma, Hematology. 2017, 1-7.

Friesen M.C., Lan Q., Ge C., Locke S.J., Hosgood D., Fritschi L., Sadkowsky T., Chen Y.C., Wei H., Chen K., Lam T.H., Kwong Y.L., Chen K., Xu C.Q., Su Y.C., Chiu B.C.H., Ip D.K.M., Purdue M.P., Bassig B.A., Rothman N. and Vermeulen R., Evaluation of automatically assigned job-specific interview modules, Annals of Occupational Hygiene. 2016, 60(7): 885-99.

Kwok G., Yau T.C.C., Chiu W.Y.J., Tse E.W.C. and Kwong Y.L., Pembrolizumab (Keytruda), Human Vaccines & Immunotherapeutics. 2016, 12: 2777-2789.

Kwong Y.L., Chan S.Y.T., Tan D., Kim S.J., Poon L.M., Mow B., Khong P.L., Loong F., Au Yeung K.H.R., Iqbal J., Phipps C. and Tse E.W.C., PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase, Blood. 2017, 129: 2437-2442.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Moffittt A.B., Ondrejka S.L., McKinney M., Rempel R.E., Goodlad J.R., Teh C.H., Leppa S., Mannisto S., Kovanen P.E., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Iqbal J., Yu J., Naresh K., Villa D., Gascoyne R.D., Said J., Czader M.B., Chadburn A., Richards K.L., Rajagopalan D., Davis N.S., Smith E.C., Palus B.C., Tzeng T.J., Healy J.A., Lugar P.L., Datta J., Love C., Levy S., Dunson D.B., Zhuang Y., Hsi E.D. and Dave S.S., Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2, The Journal of Experimental Medicine. 2017, 214: 1371-1386.

PIAO W., Chau H.W.D., Yue L.M., Kwong Y.L. and Tse E.W.C., Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma, Leukemia. 2017, 31: 522-526.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Singh G.H.H., Ip H.W., Yip S.F., Kho C.S.B., Lee K.K.H., Mak V., Lau J.S.M., Lau C.K., Lin S.Y., Wong S.M.R., Wa L.I. and Kwong Y.L., Clofarabine, Cytarabine And Mitoxantrone (CLAM) for relapsed or refractory acute myeloid leukaemia - interim results of a prospective phase 2 study, 22nd Congress of the European Haematology Association. 2017.

Singh G.H.H., Wong R.S.M. and Kwong Y.L., From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag, Therapeutic Advances in Hematology. 2017, 204062071769357.

Tse E.W.C. and Kwong Y.L., Diagnosis and management of extranodal NK/T cell lymphoma nasal type, Expert Review of Hematology. 2016, 9: 861-871.

Researcher : LAM SY

List of Research Outputs

He B.A., LAM S.Y., CHER C.Y., NG K.L. and Leung A.Y.H., Follistatin is a critical mediator for FLT3/ITD+ acute myeloid leukemia, Experimental Hematology. 2016, 44: S79.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Lam Y.M., LAM S.Y., Leung A.Y.H. and Ng R.K., Tumor suppressive role of BMI-1 through inhibition of JAK-STAT signaling in leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Researcher : LEE CP

List of Research Outputs

LEE C.P., Exploring Chemokines and Cytokines as Biomarkers for Lupus Nephritis , HKU, MPhil thesis. 2016.

YIM L.Y., YAN S., LEE C.P., Chan V.S.F. and Lau W.C.S., Dendritic cells display aberrant Toll-like receptor 7/9 responses in systemic lupus erythematosus, Asian Congress on Autoimmunity 2017 & Lupus 2017.

Researcher : LEE PC

List of Research Outputs

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Researcher : LEONG KW

List of Research Outputs

Cheng C.W., Leong K.W. and Tse E.W.C., Understanding the role of PIN1 in hepatocellular carcinoma, World Journal of Gastroenterology. 2016.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Researcher : LEUNG LL

List of Research Outputs

Lam S.K., LEUNG L.L., Li Y.V., Zheng C. and Ho J.C.M., Combination effects of arsenic trioxide and fibroblast growth factorreceptor inhibitor in squamous cell lung carcinoma, Lung Cancer. 2016, 101: 111-119.

Lam S.K., Li Y.V., XU S., LEUNG L.L., U K.P., ZHENG Y.F., CHENG P.N. and Ho J.C.M., Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts, Respiratory Research. 2017, 18(1): 80.

Researcher : LI J

List of Research Outputs

CHEN J., LI J., Xu A. and Woo W.H.C., Metabolic Function of TIR-Domain-containing adapter-inducing interferon-b (TRIF) in hepatocytes, In: Federation of American Societies for Experimental Biology, FASEB Science Research Conference: Immunological Aspects of Obesity. 2016.

CHEN J., Li J., Xu A. and Woo W.H.C., Metabolic function of TIR-domain-containing adapter-inducing interferon-b (TRIF) in hepatocytes, FASEB Science Research Conferences, July 31- August 5, 2016, Big Sky, Montana. 2016.

Researcher : LI L

List of Research Outputs

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Researcher : LI N

List of Research Outputs

CHOY H.K., Yung S.S.Y., LI N., Cheung K.F. and Chan D.T.M., EDA+ Fibronectin in Tubulo-interstitial Injury in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Researcher : LI X

List of Research Outputs

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : LI Z

List of Research Outputs

WANG L., Wong K.Y., LI Z. and Chim J.C.S., Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia, Oncotarget. 2016.

Researcher : LIANG X

List of Research Outputs

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : LIANG Y

List of Research Outputs

CUI Y., Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells, Toxicology Letters. 2017, 268: 44-50.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Liang Y., Ip M.S.M. and Mak J.C.W., The 3rd Prize for Outstanding Poster Presentation, 20th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. Hong Kong, Journal of the Hong Kong College of Cardiology, 2016, 24: 86.

Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Differential inflammatory responses resulted from cellular senescence induced by doxorubicin and antimycin in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J . Hong Kong, HK Academy of Medicine Press, 2017, 23: 33.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : LIAO B

List of Research Outputs

GENG L., LIAO B., JIN L., HUANG Z., Woo W.H.C., Lam K.S.L. and Xu A., Chronic exercise alleviated dietary obesity-associated metabolic dysfunction by enhancing FGF-21 sensitivity in adipose tissues., The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Researcher : LIU F

List of Research Outputs

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Researcher : Lai CL

Project Title:	A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2003

Project Title:	Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	10/2003

Project Title:	A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Idenix Pharmaceuticals, Inc - General Award
Start Date:	01/2004

Project Title:	Outstanding Researcher Award 2003-2004
Investigator(s):	Lai CL
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	07/2004

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chan H.L., Tsang O.T., Hui Y.T., Fung J.Y.Y., Lui G.C., Lai C.L., Wong G.L., Chan K.H., But Y.K.D., Lai M.S., Lao W.C., Chan C., Lam Y.S., Seto W.K.W., Li C., Yuen R.M.F. and Wong V.W., Real-Life Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir in Chronic Hepatitis C Patients in Hong Kong, Journal of Gastroenterology and Hepatology. 2016, 32(6): 1230-33.

Chan H.L.Y., Lai C.L., Feld J., Reau N., Han L., McNabb B.L., McNally J., Brainard D.M., Foster G. and Roberts S., Sofosbuvir/velpatasvir for 12 weeks results in high SVR12 rates with a favorable safety profile in asian patients: an integrated subgroup analysis of the ASTRAL-1, ASTRAL-2, and ASTRAL-3 studies. Plenary Presentation, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11 (Suppl 1): S1.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of primary biliary cholangitis in Hong Kong: Results from the public healthcare system database from 2000 to 2015. [Poster presentation, Hepatology 2016; 64(S1):198A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., High level of Wisteria floribunda agglutinin-positive human Mac-2 binding protein is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral treatment. Oral Presentation, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11 (Suppl 1): S72.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Predictive factors of hepatocellular carcinoma and transplant-free survival in Chinese patients with primary biliary cholangitis. [Poster presentation, Hepatology 2016; 64(S1):678A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid, Clin Transl Gastroenterol. 2017, 8(6): e100.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic factors for transplant-free survival and external validation of prognostic models in Chinese patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S544.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy, J Viral Hepat. 2017, 24(8): 654-61.

Cheung K.S., Seto W.K.W., Wong D.K.H., Mak L.Y., Lai C.L. and Yuen R.M.F., Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment, Oncotarget. 2017, 8(29): 47507-17.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Fielding R., Lam W.W.T., Liao Q., Lai C.L., Tsang W.H.J., Ip D.K.M. and Yuen R.M.F., Perceptions of cancer risk and self-care practices: comparison of groups at different risk for cancers, Hong Kong Medical Journal. 2016, 22 Suppl 6(6): 8-12.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Sin S.L., Ma K.W., Ng K.C.K., Ng K.C.K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Long Term Outcomes of Entecavir Monotherapy for Chronic Hepatitis B after Liver Transplantation: Results up to 8 years, Hepatology. 2017, 66(4): 1036-44.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Ng K.C.K., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L. and Yuen R.M.F., No increase in graft fibrosis for hepatitis B surface antigen positive patients after liver transplantation using entecavir monotherapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL). Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S184-S185.

Gane E., Schwabe C., Given B., Schluep T., Hamilton J., Lai C.L., Locarnini S., Lau J., Ferrari C. and Gish R., A phase 1 study to evaluate safety and tolerability of escalating single doses of the hepatitis B virus RNA interference drug ARC-521 in a healthy volunteer population, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S265.

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., 45-year Long Service Award, The University of Hong Kong. 2017.

Lai C.L., Chairperson, Keynote Lecture on updates on HCV treatment by Prof Ming-lung Yu, State Key Laboratory for Liver Research Symposium 2016, 8 October 2016, Hong Kong. 2016.

Lai C.L., Chairperson, Parallel session 5: Hepatitis HIV Co-infection, 2^nd Asia Pacific AIDS & Co-infections Conference (APACC), 2 June 2017, Hong Kong Convention & Exhibition Centre, Hong Kong. 2017.

Lai C.L., Chairperson, Symposium IV: Future perspectives, 29^th Annual Scientific Meeting and International Symposium on Hepatology 2016, The Hong Kong Association for the Study of the Liver Diseases, 20 Nov 2016, Hong Kong. 2016.

Lai C.L., Member, International Advisory Board, The Lancet Gastroenterology & Hepatology. 2017.

Lai C.L., Moderator, Concurrent Session: Biomarkers for HBV Diagnosis and On-treatment Monitoring, the 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL), 15-19 February 2017, Shanghai, China. 2017.

Lai C.L., Occult HBV, Concurrent Session: Viral Hepatitis and Co-Infection, the 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL), 15-19 February 2017, Shanghai, China. 2017.

Lai C.L., Optimizing HCV management: the role of ribavirin, Symposium on Leading Change in Hepatitis C, 8 September 2016, Hong Kong,. 2016.

Lai C.L., Practical guidance on treating chronic hepatitis B virus infection: real-life cases from my patients, IL‐17 Summit, Hong Kong, 27 August 2016, Hong Kong. 2016.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Lai C.L., Simplifying hepatitis C treatment - Myth or reality?, Satellite Symposium, GUT 2016 – Annual Scientific Meeting of Malaysian Society of Gastroenterology & Hepatology (MSGH), 22-24 July 2016, Kuala Lumpur, Malaysia. 2016.

Lai C.L., Sofosbuvir/Velpatasvir for 12 weeks results in high SVR12 rates with a favorable safety profile in Asian patients: an integrated subgroup analysis of the ASTRAL-1, ASTRAL-2, and ASTRAL-3 studies, Plenary Presentation, the 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL), 15-19 February 2017, Shanghai, China. 2017.

Lai C.L., Treatment of Chronic Hepatitis B, Seminar on Viral Hepatitis for Nurses and Allied Health Professionals, Department of Health, Centre for Health Protection, 1 June 2017, Hong Kong. 2017.

Lai C.L., Treatment to eradicate Hepatitis B- is there light at the end of the tunnel?, Symposium 4 - Viral Hepatitis, GUT 2016 – Annual Scientific Meeting of Malaysian Society of Gastroenterology & Hepatology (MSGH), 22-24 July 2016, Kuala Lumpur, Malaysia. 2016.

Lai C.L., Update on Chronic Hepatitis C Studies, Infection Control Association of Macao Scientific Meeting, 24 Feb 2017, Macau. 2017.

Lai C.L., Update on Chronic Hepatitis C Studies, Round-table Dinner Discussion, 10 May 2017, Hong Kong. 2017.

Lai C.L., Update on HCV Management, Plenary Lecture at the 22^nd Medical Research Conference, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, 14 January 2017, Hong Kong. 2017.

Lai C.L., Work Group Member, Kidney Disease: Improving Global Outcomes (KDIGO) to update the KDIGO Clinical Practice Guidelines for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease last published in April 2008, in Kidney International, http://kdigo.org/home/hepatitis-c-in-ckd/. 2016.

Lai C.L., 擊退乙肝, 肝炎與肝癌專題講座, 香港乙肝基金會 (Hong Kong Hep B Free Foundation), 3 June 2017, 歐陽均諾議員辦事處及何華漢議員辦事處協辨, 九龍灣佛教慈敬學校. 2017.

Li J., Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of IL-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection. [Poster presentation, Hepatology 2016; 64(S1):877A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Li J., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver Int. 2017, 37(9): 1287-94.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Mak L.Y., Seto W.K.W., Hui R., Fung J.Y.Y., Cheung K.S., Lai C.L. and Yuen R.M.F., Nucleos(t)ide analogue decreased liver stiffness of e-antigen negative chronic hepatitis B (CHB) patients over a 10-year interval, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S251.

Nguyen M.H., Chuang W.L., Hassanein T., Kowdley K., Lai C.L., Chan H.L.Y., Feld J.J., Letterio C., Hahambis T.A., Llewellyn J., De-Oertel S., Brainard D.M., Lawitz E.J. and Gane E.J., Integrated analysis of controlled clinical trials evaluating efficacy and safety of sofosbuvir-based regimens in chronic hepatitis C genotype 6 (HCV GT 6), The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S723.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Fung J.Y.Y., Cheung K.S., Mak L.Y., Hui R.W.H., Liu S.H.K., Lai C.L. and Yuen R.M.F., Body-mass index is associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B., Alimentary Pharmacology and Therapeutics. 2016, 44: 1071-1079.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Yuen R.M.F., Liu S.H.K., Chan H.L.Y., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lau J.Y., Ferrari C. and Gish R.G., Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S27.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Lai KN

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Lai KWH

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Lai YKA

List of Research Outputs

Lai Y.K.A., Fong D.Y.T., Lam C.M.J. and Ip M.S.M., Long-term efficacy of an education programme in improving adherence with continuous positive airway pressure treatment for obstructive sleep apnoea, Hong Kong Medical Journal. 2017, 23(Suppl 2): S24-27.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Researcher : Lam CCS

List of Research Outputs

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Researcher : Lam CL

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2011

Project Title:	Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):	Lam CLD, Wan SKT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2012
Completion Date:	08/2016

Project Title:	Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

List of Research Outputs

Researcher : Lam CLD

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2011

Project Title:	Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):	Lam CLD, Wan SKT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2012
Completion Date:	08/2016

Project Title:	Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

List of Research Outputs

Azzopardi M., Thomas R., Muruganandan S., Lam C.L.D., Garske L.A., Kwan B.C., Rashid A.M.R., Nguyen P.T., Yap E., Horwood F.C., Ritchie A.J., Bint M., Tobin C.L., Shrestha R., Piccolo F., De Chaneet C.C., Creaney J., Newton R.U., Hendrie D., Murray K., Read C.A., Feller-Kopman D., Maskell N.A. and Lee Y.C., Protocol of the Australasian Malignant Pleural Effusion-2 (AMPLE-2) trial: a multicentre randomised study of aggressive versus symptom-guided drainage via indwelling pleural catheters, BMJ Open. 2016, 6: e011480.

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Kwok W.C., Tam C.C.T., Lui M.S.M., Lam C.L.D. and Ho J.C.M., Control of brain metastases with alectinib in anaplastic lymphoma kinase-rearranged lung cancer, Respirology Case Reports. 2017, 5(3): e00224.

Kwok W.C., Lam S.H., Wong M.P., Ip M.S.M. and Lam C.L.D., Influenza B/Streptococcal co-infection complicated by organizing pneumonia, Respirology Case Reports. 2016, 4(5): e00170.

Lam C.L.D., Biomarkers for personalized management of advanced stage lung cancer, Annual Scientific Meeting of Federation of Medical Societies of Hong Kong, July, 2016. 2016.

Lam C.L.D., Biomarkers for personalized management of advanced stage lung cancer, FMSHK Annual Scientific Meeting 2016.

Lam C.L.D., Biomarkers for precision medicine in advanced stage lung cancer, Annual Scientific Meeting of the Vietnam Respiratory Society, September 2016, Hanoi, Vietnam. 2016.

Lam C.L.D., Ho J.C.M. and Ip M.S.M., Respiratory medicine: Short Cases, Problem Based Medical Case Management, Second Edition. Hong Kong, Hong Kong University Press, 2016, 178-194.

Researcher : Lam CLK

Project Title:	Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):	Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):	Lam CLK, Wong W
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	Extended evaluation of quality of care of chronic disease management programmes and public-private partnership programmes of the Hospital Authority
Investigator(s):	Lam CLK, Wong WCW, Chin WY, Chen JY, Fung SCC, Fong DYT, Yu YTE
Department:	Family Med & Primary Care
Source(s) of Funding:	Commissioned Study on Enhanced Primary Care
Start Date:	07/2011
Completion Date:	04/2017

Project Title:	Provision of Data Analysis and Report Writing Services for Conducting the Population Health Survey 2014/15
Investigator(s):	Lam CLK, Cheung BMY, Yu YTE, Wong CKH, Guo Y
Department:	Family Med & Primary Care
Source(s) of Funding:	Department of Health - General Award
Start Date:	07/2016

Project Title:	ISOQOL 23rd Annual Conference; Changes in health-related quality of life among adults from low income families in Hong Kong
Investigator(s):	Lam CLK
Department:	Family Med & Primary Care
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2016
Completion Date:	10/2016

Researcher : Lam CMJ

List of Research Outputs

Lai Y.K.A., Fong D.Y.T., Lam C.M.J. and Ip M.S.M., Long-term efficacy of an education programme in improving adherence with continuous positive airway pressure treatment for obstructive sleep apnoea, Hong Kong Medical Journal. 2017, 23(Suppl 2): S24-27.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Researcher : Lam CSC

List of Research Outputs

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Researcher : Lam KSL

Project Title:	The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2006

Project Title:	Ageing
Investigator(s):	Lam KSL, Xu A, Lum TYS
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Establishing a Phase 1 Clinical Trials Centre in Queen Mary Hospital: Extending Hong Kong's Competitive Edges in Healthcare, Education and Life Sciences Research and Development
Investigator(s):	Lam KSL, Lau YL, Cheung BMY, Lam CW, Yau HKC
Department:	Medicine
Source(s) of Funding:	Commissioned Programme on Phase 1 Clinical Trials Centre
Start Date:	02/2014

List of Research Outputs

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Cheung B.M.Y., wang Y., Lam K.S.L. and Tse H.F., Is endothelial function related to plasma level of lipocalin-2 in man?, Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Cheung B.M.Y., Fong C.H.Y., Chen C., Cho A.W.K., Wang Y., Law L.S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., LBPS 02-06 PLASMA LEVEL OF FIBROBLAST GROWTH FACTOR 21 IS INDEPENDENTLY RELATED TO BLOOD PRESSURE, Journal of Hypertension. 2016, 34: e507.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

GENG L., LIAO B., JIN L., HUANG Z., Woo W.H.C., Lam K.S.L. and Xu A., Chronic exercise alleviated dietary obesity-associated metabolic dysfunction by enhancing FGF-21 sensitivity in adipose tissues., The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

KWOK H.M. and Lam K.S.L., Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis, Endocrinology and Metabolism (Seoul). 2017, 32: 145.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lam K.S.L., Associate Editor, Journal of Diabetes Investigation. 2016.

Lam K.S.L., Editorial Board Member, Endocrinology and Metabolism. 2017.

Lam K.S.L., Editorial Board Member, Journal of the Endocrine Society. 2016.

Lam K.S.L., Hyperaldosteronism – Review - Is it common?, 4th China Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) 11-13 May 2017, Shanghai. 2017.

Lam K.S.L., Inflammation and atherosclerosis: role of adipokines, 5th International Congress on Lipid Metabolism &Atherosclerosis (ICLA 2016), September 90, 2016, Korea. 2016.

Lam K.S.L., SGLT-2 Inhibitor In Clinical Practice—Asian Data And Experience Sharing, 4th China Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) 11-13 May 2017, Shanghai. 2017.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.H.P., Woo Y.C., Yuen M.M.A., Fong H.Y., Cheung B.M.Y. and Lam K.S.L., Obesity indices in the prediction of incident type 2 diabetes mellitus in a long- term cohort study of Hong Kong Chinese, The International Diabetes Federation World Diabetes Congressm Vancouver, Canada . 2016.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Li R.H.W., Lam K.S.L., Tam S., Shek A.C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum Vitamin D Concentration Is Independently Associated With Anti-mullerian Hormone Level And Obesity Measures In Hong Kong Chinese Women With Polycystic Ovary Syndrome, 17th International Congress of Endocrinology cum 15th Annual Meeting of Chinese Society of Endocrinology. 2016.

Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum Vitamin D concentration is independently associated with anti-Mullerian hormone level and obesity measures in Hong Kong Chinese women with polycystic ovary syndrome., The 17th International Congress of Endocrinology and the 15th Annual Meeting of the Chinese Society of Endocrinology. 2016.

Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum vitamin D concentration is independently associated with anti-Mullerian hormone and obesity measures in Hong Kong Chinese women with polycystic ovary syndrome, The 17th International Congress of Endocrinology and the 15th Annual Meeting of the Chinese Society of Endocrinology. 2016.

Luk A.O.Y., Hui E.M.T., Sin M.C., Yeung C.Y., Chow W.S., Ho A.Y.Y., Hung H.F., Kan E., Ng C.M., So W.Y., Yeung C.K., Chan K.S., Chan K.W., Chan P.F., Siu S.C., Tiu S.C., Yeung T.F., Chan J.C.N., Chan F.W.K., Chan C., Cheung N.T., Ho S.T., Lam K.S.L., Yu L.W.L., Chao D. and Lau I.T., Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database, Diabetes Care. 2017, 40: 928-935.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Shih K.C., Lam K.S.L. and Tong L., A systematic review on the impact of diabetes mellitus on the ocular surface, Nutrition & Diabetes. 2017, 7: e251.

Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein (A-FABP) in obesity and its related complications: Friend or Foe?, 4th Lingnan International Symposium of Metabolic Diseases: Frontiers in Immunometabolism. 2017.

WU X., Shu L., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of liver fibrosis, FASEB Science Research Conference. 2017.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

Zhou M., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP)is a potential mediator of heart dysfunction and failure related to obesity, the 11th International Diabetes Federation Western Pacific Region Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes in Taipei, Taiwan . 2016.

Researcher : Lam KYJ

List of Research Outputs

LAU C.Y., Chan E.W., Cheung C.L., SING C.W., Man K.C.K., Lip G.Y.H., Siu D.C.W., Lam K.Y.J., Lee C.H.A. and Wong I.C.K., Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation, JAMA. 2017, 317: 1151.

Researcher : Lam MF

List of Research Outputs

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Lam SK

Project Title:	Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):	Lam SK
Department:	Medicine
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Project Title:	Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):	Lam SK, Wong BCY, Lin MC
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2004

Researcher : Lam SK

Project Title:	In Vitro and in vivo combination of arginase and chemotherapeutic drugs in squamous cell lung carcinoma
Investigator(s):	Lam SK, Ho JCM
Department:	Medicine
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	03/2016

Project Title:	Targeting polyamine for prevention and therapy in malignant pleural mesohelioma
Investigator(s):	Lam SK, Ho JCM
Department:	Medicine
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	12/2016

List of Research Outputs

Ho J.C.M. and Lam S.K., Combination of Arginine Depletion and Chemotherapy in Thoracic Malignancies, Journal of Clinical Oncology. 2017, 35(16): 1758-1759.

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. WCLC 2016, Vienna (Abstract ID 4859)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna Austria. 2016.

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Suppression of tumour growth by pegylated arginase in malignant pleural mesothelioma. WCLC 2016, Vienna (Abstract ID 4854)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Lam S.K., LEUNG L.L., Li Y.V., Zheng C. and Ho J.C.M., Combination effects of arsenic trioxide and fibroblast growth factorreceptor inhibitor in squamous cell lung carcinoma, Lung Cancer. 2016, 101: 111-119.

Lam S.K., Li Y.V., XU S., LEUNG L.L., U K.P., ZHENG Y.F., CHENG P.N. and Ho J.C.M., Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts, Respiratory Research. 2017, 18(1): 80.

Lam S.K., XU S. and Ho J.C.M., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, 22nd Medical Research Conference. 2017, 23: 26.

XU S., Lam S.K., Cheng P.N. and Ho J.C.M., In vitro effects of pegylated arginase in small cell lung cancer. WCLC 2016, Vienna (Abstract ID 4163)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Researcher : Lam WK

List of Research Outputs

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Researcher : Lam YF

List of Research Outputs

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

Researcher : Lam YM

List of Research Outputs

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Researcher : Lan HY

Project Title:	Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Sun Chieh Yeh Heart Foundation - General Award
Start Date:	08/2006

Project Title:	Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Baxter Health Care Ltd. - General Award
Start Date:	05/2008

Project Title:	Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	05/2008

Researcher : Lan XR

Project Title:	Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):	Lan XR, Lan HY, Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Researcher : Lau CP

Project Title:	Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):	Lau CP, Lee KLF
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/2000

Project Title:	Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):	Lau CP, Yu CM, Lan HY
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

List of Research Outputs

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

Cheung B.M.Y., Cheng C.H., Lau C.P., Wong C.K.Y., Ma R.C.W., Chu D.W.S., Ho D.H.K., Lee K.L.F., Tse H.F., Wong A.S.P., Yan B.P.Y. and Yan W.T., 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population, Hong Kong Medical Journal. 2017, 191-201.

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

Researcher : Lau G

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

Researcher : Lau GKK

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

Researcher : Lau GKK

List of Research Outputs

Hurford R., Li L., Lau G.K.K., Lyons S., Kubiak M., Kuker W. and Rothwell P.M., Long-term prognostic value of acute DWI lesions in TIA and minor ischaemic stroke: a population based study, 3rd European Stroke Organisation Conference. 2017.

Kwan S.K.J., Myint P.K., Wong A., Mok V., Lau G.K.K. and Mak H.K.F., Antithrombotic Therapy To Prevent Cognitive Decline In People With Small Vessel Disease On Neuroimaging But Without Dementia (Protocol), Cochrane Database Of Systematic Reviews. 2016, Issue 7.

Kwan S.K.J., Myint P.K., Wong A., Mok V., Lau G.K.K. and Mak H.K.F., Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementa (Protocol). , Cochrane Database of Systematic Reviews 2016, Issue 7. Art. No.: CD012269. 2016 The Cochrane Collaboration. . John Wiley & Sons, Ltd., 2016.

Lau G.K.K., Li L., Lovelock C.E., Zamboni G., Chan T.T., Chiang M.F., Lo K.T., Kuker W., Mak H.K.F. and Rothwell P.M., Clinical Correlates, Ethnic Differences, and Prognostic Implications of Perivascular Spaces in Transient Ischemic Attack and Ischemic Stroke, Stroke. 2017, 48: 1470-1477.

Lau G.K.K., Li L., Lovelock C., Zamboni G., Chan T.T., Chiang M.F., Lo K.T., Kuker W., Mak H.K.F. and Rothwell P.M., Clinical correlates, ethnic differences and prognostic implications of perivascular spaces in TIA and ischaemic stroke, 3rd European Stroke Organisation Conference. 2017.

Lau G.K.K., Editorial Board Member, Neurology and Neuroscience Research. 2017.

Lau G.K.K., Prognostic implications of cerebral microbleeds in patients with transient ischaemic attack and stroke on antiplatelet agents, Stroke seminar, John Radcliffe Hospital, Oxford, UK. 2016.

Lau G.K.K., Li L., Lovelock C.E., Simoni M., Schulz U., Zamboni G., Wong Y.K., Teo K.C., Rothwell P.M. and Mak H.K.F., Prognostic implications of neuroimaging markers of small vessel disease in patients with transient ischemic attack and ischemic stroke, Thomas Willis Day, University of Oxford. 2017.

Lau G.K.K., Li L., Schulz U., Simoni S., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke – validation in two large cohorts, 3rd European Stroke Organisation Conference. 2017.

Lau G.K.K., Li L., Schulz U., Simoni M., Chan K.H., Ho S.L., Cheung R.T.F., Kuker W., Mak H.K.F. and Rothwell P.M., Total small vessel disease score and risk of recurrent stroke: validation in 2 large cohorts, Neurology. 2017, 88: 2260-2267.

Lau G.K.K., Update on stroke prevention , Marcham Road Family Health Centre, Oxford, UK. 2016.

Lau G.K.K., Update on stroke prevention, Oxford Vascular Study, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. 2016.

XU X., Mak H.K.F., Lau G.K.K., Lam P.L. and Hui S.K., Impact of the Topology of Brain Microbleeds on the Structural Brain Network, The 25th Annual Meeting of ISMRM, Honolulu, Hawaii, USA. 2017. 2427.

Researcher : Lau JSM

List of Research Outputs

Singh G.H.H., Ip H.W., Yip S.F., Kho C.S.B., Lee K.K.H., Mak V., Lau J.S.M., Lau C.K., Lin S.Y., Wong S.M.R., Wa L.I. and Kwong Y.L., Clofarabine, Cytarabine And Mitoxantrone (CLAM) for relapsed or refractory acute myeloid leukaemia - interim results of a prospective phase 2 study, 22nd Congress of the European Haematology Association. 2017.

Researcher : Lau KS

List of Research Outputs

Li T.H., Qin Y., Sham P.C., Lau K.S., Chu K.M. and Leung W.K., Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis, Scientific Reports. 2017, 7: 44935.

MA Z., Lau K.S., Law W.L. and Leung W.K., ., Comparison Of Methylated Septin 9 With Carcinoembryonic Antigen In Monitoring Of Colorectal Cancer Patients After Curative Surgery, Digestive Disease Week, Chicago, USA, 6-9 May 2017.

Researcher : Lau VYM

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

Researcher : Lau WCS

Project Title:	Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1993

Project Title:	Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):	Lau WCS, Mok MYT
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):	Lau WCS, Chan YTE, Cheung BMY
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Project Title:	Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2012

Project Title:	The role of plasmacytoid dendritic cells in systemic lupus erythematosus
Investigator(s):	Lau WCS, Chan VSF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	Advances in Immunology in Health and Disease
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Croucher Summer Courses
Start Date:	07/2014

Project Title:	Validation of a new definition of lupus low disease activity state (LLDAS): Clinical and management implications
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2016

List of Research Outputs

Chan C.W.S., Chung H.Y., Lau W.C.S. and Tsang H.L.H., Spontaneous pneumomediastinum in a dermatomyositis patient with anti-melanoma differentiation-associated gene-5 antibody and interstitial lung disease despite an initial response to immunosuppressant, International Journal of Rheumatic Diseases. 2017.

Chan L.K., Wong F.K.Y., Ganotice F.J.A., Lau W.C.S., Lam T.P., Bridges S.M., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Chin W.Y., Harbutt D., Khoo U.S., Lam S.F., Lao L., Leung G.K.K. and Li Q., Bronze in Discipline Award (Life Sciences), in Quacquarelli Symonds (QS) Reimagine Education competition: Interprofessional Team-Based Learning for Health Professional Students, Quacquarelli Symonds. 2016.

Chung H.Y., Lau W.H.V., Lau W.C.S. and Tsang H.L.H., Comparing Diffusion Weighted Imaging (dwi) With Clinical And Blood Parameters, And With Short Tau Inversion Recovery (stir) Sequence In Detecting Spinal And Sacroiliac (si) Joint Inflammation In Axial Spondyloarthritis (axspa), Clinical Experimental Rheumatology. 2017.

Chung H.Y., XU X., Lau W.H.V., Ho G., Lee K.L., Li P.H., Tsang H.L.H., Kwok S.K., Lau W.C.S. and Wong C.S., Comparing diffusion weighted imaging with clinical and blood parameters, and with short tau inversion recovery sequence in detecting spinal and sacroiliac joint inflammation in axial spondyloarthritis., Clin Exp Rheumatol. 2017, 35(2): 262-269.

Deng Y., Wang Z., Chang C., Lu L., Lau W.C.S. and Lu Q., Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials, Human Immunology. 2017, 78: 120-128.

Franklyn K., Lau W.C.S., Navarra S.V., Louthrenoo W., Lateef A., Hamijoyo L., Wahono C.S., Chen S.L., Jin O., Morton S., Hoi A., Huq M., Nikpour M. and Morand E.F., Definition and initial validation of a Lupus Low Disease Activity State (LLDAS), Annals of the Rheumatic Diseases. 2016, 75: 1615-1621.

Golder V., Huq M., Franklyn K., Calderone A., Lateef A., Lau W.C.S., Lee A.L.H., Navarra S.T.V., Godfrey T., Oon S., Hoi A.Y.B., Morand E.F. and Nikpour M., Does expert opinion match the operational definition of the Lupus Low Disease Activity State (LLDAS)? A case-based construct validity study, Seminars in Arthritis and Rheumatism. 2017, 46: 798-803.

Golder V., Kandane-Rathnayake R., Hoi A.Y.B., Huq M., Louthrenoo W., An Y., Li Z.G., Luo S.F., Sockalingam S., Lau W.C.S., Lee A.L., Mok M.Y.T., Lateef A., Franklyn K., Morton S., Navarra S.T.V., Zamora L., Wu Y.J., Hamijoyo L., Chan M., O’Neill S., Goldblatt F., Morand E.F. and Nikpour M., Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort, Arthritis Research & Therapy. 2016, 18.

Huang X., Wu H., Qiu H., Yang H., Deng Y., Zhao M., Luo H., Zhou X., Xie Y., Chan V.S.F., Lau W.C.S. and Lu Q., The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus, Clinical Immunology. 2016, 173: 161-170.

Lau W.C.S., APLAR Center of Excellence for Research, Training and Education and Patient Care Award (from September 2016 - September 2019), APLAR Centers of Excellence. 2016.

Lau W.C.S., Biologic Therapies in Rheumatoid Arthritis: Are They Worth It?, Public Lecture Series 2017. Lecture Theatre, The Hong Kong Central Library, 10 June 2017. 2017.

Lau W.C.S., Biosimilar and biologic: how can we communicate with our patients:, The Hong Kong Society of Rheumatology, Sheraton Hong Kong Hotel & Tower, 12 Oct 2016. 2016.

Lau W.C.S., Diagnosis of inflammatory arthritis., The 12th Rehabilitation Symposium cum the 5th Sir Harry Fang Oration of the Hong Kong College of Orthopaedic Surgeons, Prince of Wales Hospital, 22-23 October 2016. 2016.

Lau W.C.S. and Li P., Epidemiology: The effects of AIDS on the prevalence of rheumatic diseases, Nature Reviews Rheumatology. 2016, 13: 8-10.

Lau W.C.S., From Common Core Curriculum to the 130th MBBS Curriculum Reform., General Education Conference 2017: Evolution and Transformation. The Hong Kong Polytechnic University 15-16 June 2017. 2017.

Lau W.C.S., Meet the Professor: A career in lupus/research: tips and inspiration., LUPUS 2017 and ACA 2017 Congress, Melbourne, Australia 26-29 March 2017. 2017.

Lau W.C.S., Meet the Professor: East meets West: Difficult Lupus., LUPUS 2017 and ACA 2017 Congress, Melbourne, Australia 26-29 March 2017. 2017.

Lau W.C.S., Meet the Professor: Lupus nephritis: assessing disease activity and severity., LUPUS 2017 and ACA 2017 Congress, Melbourne, Australia 26-29 March 2017. 2017.

Lau W.C.S., Treat to target in systemic lupus erythematosus: What target(s)?, 粤港京风湿免疫研讨会暨第四届港大风湿论坛,香港大学深圳医院讲学厅（2016年8月7日）. 2016.

Lau W.C.S., Treating to target in Systemic Lupus Erythematosus: What target(s)?, The 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2016) Shanghai, China, 26-29 September 2016. 2016.

Lau W.C.S., Treating-to-target in SLE: What Targets?, International Conference of Chinese Rheumatologists (ICCR) cum Hong Kong Society of Rheumatology Annual Scientific Meeting cum Guangdong-Hong Kong Rheumatology Seminar, Regal Kowloon Hotel, 26-27 November 2016. 2016.

Lau W.C.S., Tribute to Professor PH Feng., LUPUS 2017 and ACA 2017 Congress, Melbourne, Australia 26-29 March 2017. 2017.

Lau W.C.S., Updates on medical treatment of inflammatory arthritis., The 12th Rehabilitation Symposium cum the 5th Sir Harry Fang Oration of the Hong Kong College of Orthopaedic Surgeons, Prince of Wales Hospital, 22-23 October 2016. 2016.

Lau W.C.S., Validation of the Lupus low disease activity score., LUPUS 2017 and ACA 2017 Congress, Melbourne, Australia 26-29 March 2017. 2017.

Lau W.C.S., What has shaped workforce strategy in Hong Kong?, IGHPE 2017 Shanghai Conference: Innovative Strategies for Developing the Future Healthcare Workforce, Shanghai, 5-7 April, 2017. 2017.

Lau W.C.S., “What if the workplace is away from home?”, Medical Education Conference. The Chinese University of Hong Kong, 10-11 March 2017. 2017.

Leung M.H.A., Farewell D., Lau W.C.S. and Choy E.H.S., Defining criteria for rheumatoid arthritis patient-derived disease activity score that correspond to Disease Activity Score 28 and Clinical Disease Activity Index based disease states and response criteria, Rheumatology. 2016, kew279.

Li P.H. and Lau W.C.S., Lupus in the far east: a modern epidemic, International Journal of Rheumatic Diseases. 2017, 20: 523-525.

Li W.M.M., YIM L.Y., Chan V.S.F. and Lau W.C.S., Autoimmune-associated Gene Clec16a Regulates Nlrp3 But Not Aim2 Inflammasome Pathway In Human Macrophages, Asian Congress of Autoimmunity 2017 & Lupus 2017.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Qiu H., Wu H., Chan V.S.F., Lau W.C.S. and Lu Q., Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity, Autoimmunity. 2017, 50: 71-81.

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

Wang Z., Yin H., Lau W.C.S. and Lu Q., Histone Posttranslational Modifications of CD4+ T Cell in Autoimmune Diseases, International Journal of Molecular Sciences. 2016, 17: 1547.

XU X., Hui S.K., Mok M.Y.T., Jiang J., Lau W.C.S. and Mak H.K.F., Structural Brain Network Reorganization in Patients with Neuropsychiatric Systemic Lupus Erythematosus, American Journal of Neuroradiology. 2016.

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553.

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017.

YIM L.Y., YAN S., LEE C.P., Chan V.S.F. and Lau W.C.S., Dendritic cells display aberrant Toll-like receptor 7/9 responses in systemic lupus erythematosus, Asian Congress on Autoimmunity 2017 & Lupus 2017.

Zhang Q., Ding S., Zhang H., Long H., Wu H., Zhao M., Chan V.S.F., Lau W.C.S. and Lu Q., Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus., Clin Epigenetics. 2016, 8: 126.

Researcher : Lee CHA

List of Research Outputs

LAU C.Y., Chan E.W., Cheung C.L., SING C.W., Man K.C.K., Lip G.Y.H., Siu D.C.W., Lam K.Y.J., Lee C.H.A. and Wong I.C.K., Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation, JAMA. 2017, 317: 1151.

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Researcher : Lee CHP

Project Title:	The Role of Novel Serum Biomarkers and Dietary Pattern in Non-Alcoholic Fatty Liver Disease among Chinese patients with Type 2 Diabetes in Hong Kong
Investigator(s):	Lee CHP, Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Adipocyte fatty acid binding protein as a novel marker of the development of sight threatening diabetic retinopathy
Investigator(s):	Lee CHP, Lam KSL, Yuen MAM, Wong YHI, Fong HY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., An update on diabetes and endocrine diseases, Endocrine Course by Internship Doctors Committee, Health Bureau of Macau. 2016.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee C.H.P., Best Abstract in Clinical Medicine (Poster)-22nd Medical Research Conference, Department of Medicine, The University of Hong Kong, Department of Medicine, The University of Hong Kong. 2017.

Lee C.H.P., Croucher Foundation Fellowship 2016/2017 , Croucher Foundation . 2017.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.H.P., Non-alcoholic Fatty Liver Disease in Diabetes: Perspectives from an Endocrinologist, A to Z Symposium, Diabetes Division, Hong Kong Society of Endocrinology, Metabolism and Reproduction. 2017.

Lee C.H.P., Woo Y.C., Yuen M.M.A., Fong H.Y., Cheung B.M.Y. and Lam K.S.L., Obesity indices in the prediction of incident type 2 diabetes mellitus in a long- term cohort study of Hong Kong Chinese, The International Diabetes Federation World Diabetes Congressm Vancouver, Canada . 2016.

Lee C.H.P., Obesity, inflammation and diabetic kidney disease, The International Diabetes Federation West Pacific Region Diabetes Congress, Taipei, Taiwan. 2016.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Lee C.H.P., Osteoporosis Debate, Update on Osteoporosis Management, a Certificate Course for Clinicians. 2016.

Lee C.H.P., Personalized Management of Diabesity, The 12th International Symposium on Healthy Aging, Hong Kong. 2017.

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in Type 2 Diabetes Mellitus, 11th IDF-WPR Congress 2016 & 8th AASD Scientific Meeting, Taiwan. 2016.

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in type 2 diabetes mellitus. , 11th International Diabetes Federation Western Pacific Region Congress, Taipei, Oct 2016.. 2016.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Roles of circulating adipocyte fatty-acid binding protein and fibroblast growth factor 21 in the prediction of incident coronary heart disease among Chinese subjects with type 2 diabetes . , The 5th International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2016), Seoul.. 2016.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

Researcher : Lee CY

List of Research Outputs

XU X., Mak H.K.F., Chan K.H., Lee C.Y. and Hui S.K., Distinction between neuromyelitis optica and multiple sclerosis - from a structural brain network perspective, The 33rd Annual Scientific Meeting of ESMRMB, Vienna, Austria. 2016.

Researcher : Lee KLF

List of Research Outputs

Cheung B.M.Y., Cheng C.H., Lau C.P., Wong C.K.Y., Ma R.C.W., Chu D.W.S., Ho D.H.K., Lee K.L.F., Tse H.F., Wong A.S.P., Yan B.P.Y. and Yan W.T., 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population, Hong Kong Medical Journal. 2017, 191-201.

Researcher : Lee P

List of Research Outputs

Yap Y.H.D., Lee P., Yung S.S.Y. and Chan D.T.M., Circulating lymphocyte subsets and disease relapse in lupus nephritis, ASN Kidney Week 2016 Annual Meeting, Chicago, America. 2016.

Yap Y.H.D., Lee P., Yam I.Y.L., Tam H.Y., Wong S., Yung S.S.Y. and Chan D.T.M., Effect of Cyclophosphamide and Mycophelonate Mofetil on Lymphocyte Subsets in Patient with Active Lupus Nephritis, 54th Congress of European Renal Association-European Dialysis and Transplant Association , Madrid, Spain. 2017.

Researcher : Lee SWL

List of Research Outputs

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Chan E.Y.T., Tsui M.S.H. and Lee S.W.L., Beta-2 microglobulin level in serum is elevated in patients presenting with acute coronary syndrome., Presented at the Great Wall International Congress of Cardiology, Beijing 2016.. 2016.

Cheung B.M.Y., tam F., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E.Y.T., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Researcher : Lee TMC

Project Title:	Selective attention biases of people with major depressive disorder, and its relationship with brain damages.
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	A post-discharge service for brain injury patients in Central and Western District
Investigator(s):	Lee TMC, Chan SSC, Hung KN, Li LSW, Leung KK
Department:	Psychology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2006

Project Title:	Cognitive Dysfunction after Anesthesia (CoDA) Study
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Research Output Prize (Faculty of Social Sciences)
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Memory and attention training to reduce the risk of developing dementia
Investigator(s):	Lee TMC, Chu LW, Hou WK
Department:	Psychology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	The neural effect of focused-attention meditation and loving-kindness meditation on attention and emotion perception
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Incentive Award for RGC GRF Fundable But Not Funded Projects
Start Date:	07/2011

Project Title:	Outstanding Researcher Award 2010-11
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2011

Project Title:	Neuroscience
Investigator(s):	Lee TMC, Chan YS
Department:	Psychology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	King's/HKU Fellowship Awards 2014-15
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	07/2014

Project Title:	The impact of PM2.5 exposure associated with urbanization and climatic changes on neurobiological changes that underpin neurocognitive degeneration (CRF)
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	The neural bases of meditation for promoting healthy aging: A longitudinal multi-modal neuroimaging study
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2015

Project Title:	Service Model for Promoting Healthy Aging of Sandwich-class Older People
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Fu Tak Iam Foundation Limited
Start Date:	09/2015

Project Title:	The effect of two-session training on lying about face familiarity in high- and low-psychopathy individuals
Investigator(s):	Lee TMC, Shao Z
Department:	Psychology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Project Title:	2017 Rotman Research Institute Conference; Implications of Prefrontal Synchrony and Metastability in Emotion and Cognition
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017
Completion Date:	03/2017

Project Title:	The biobehavioral relationships between heart rate variability and anxiety
Investigator(s):	Lee TMC, Li XS
Department:	Psychology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Yau S.Y., Li A., Tong J.B., Bostrom C., Christie B.R., Lee T.M.C. and So K.F., Chronic corticosterone administration reduces dendritic complexity in mature, but not young granule cells in the rat dentate gyrus, Restorative Neurology and Neuroscience. 2016, 34: 849-857.

Researcher : Lee YK

Project Title:	The role of LMNA/C in regulation of cardiac nodal cell survival and electrophysiological function
Investigator(s):	Lee YK, Tse HF, Siu DCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	10th International Meeting on Substrate-Integrated Microelectrode Arrays (MEA 2016); Investigation in the Role of Lamin A (LMNA) Deficiency in Heart Block and Dilated Cardiomyopathy (DCM) Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
Investigator(s):	Lee YK
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	07/2016

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

Researcher : Lee YKM

List of Research Outputs

WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-intensity intermittent hypoxia promotes subcutaneous adipogenic differentiation, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 44.

Researcher : Leong KW

List of Research Outputs

Cheng C.W., Leong K.W. and Tse E.W.C., Understanding the role of PIN1 in hepatocellular carcinoma, World Journal of Gastroenterology. 2016.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Researcher : Leung AYH

Project Title:	Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):	Leung AYH, Kwong YL, Tang SCW
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2010

Project Title:	Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Study of Microglia and Myeloid Leukemia in Zebrafish
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2013

Project Title:	Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2014

Project Title:	Provision of free next generation sequencing (NGS) service of prognostic and therapeutic values for patients with acute myeloid leukemia in Hong Kong
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2016

Project Title:	Establish a zebrafish model to study the molecular and clonal heterogeneity and develop personalized treatment in FLT3-ITD+ AML
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2016

Project Title:	Provision of free decitabine for young patients with acute myeloid leukemia (AML) carrying DNMT3A mutation
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2017

Project Title:	A Comprehensive and Multidisciplinary Approach Targeting Acute Myeloid Leukaemia in Hong Kong (TRS)
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

Lam Y.M., LAM S.Y., Leung A.Y.H. and Ng R.K., Tumor suppressive role of BMI-1 through inhibition of JAK-STAT signaling in leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Leung A.Y.H., Croucher Senior Medical Research Fellowships , Croucher Foundation. 2016.

Researcher : Leung CTG

List of Research Outputs

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Researcher : Leung JCK

Project Title:	Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications
Investigator(s):	Leung JCK
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	The role of kidney injury molecule in the reparative process of injured kidney tubular epithelial cells
Investigator(s):	Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Leung MHA

List of Research Outputs

Leung M.H.A., Farewell D., Lau W.C.S. and Choy E.H.S., Defining criteria for rheumatoid arthritis patient-derived disease activity score that correspond to Disease Activity Score 28 and Clinical Disease Activity Index based disease states and response criteria, Rheumatology. 2016, kew279.

Researcher : Leung OY

List of Research Outputs

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Researcher : Leung RCY

List of Research Outputs

Leung R.C.Y., Yau T.C.C., Chan M.C., Chan S.W., Chan T.W., Tsang Y.Y., Wong T.T., Chao C., Yoshizawa C., Soong I.S., Kwan W.H., Kwok C.C., Suen J.S., Ngan R.K. and Cheung P.S., The Impact of the Oncotype DX Breast Cancer Assay on Treatment Decisions for Women With Estrogen Receptor-Positive, Node-Negative Breast Carcinoma in Hong Kong, Clinical Breast Cancer. 2016, 16: 372-378.

Researcher : Leung STS

List of Research Outputs

Leung S.T.S. and Chan K.H., Cognitive impairment in multiple sclerosis and neuromyelitis optica among Hong Kong Chinese, 32th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), London. 2016.

Researcher : Leung WK

Project Title:	Detection of methylated Septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer
Investigator(s):	Leung WK, Shin VY, Law WL
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014
Completion Date:	11/2017

Project Title:	Use of Fecal Calprotection for Diagnosis and Monitoring of Patients with Inflammatory Bowel Disease
Investigator(s):	Leung WK, Hung FNI, Liu SHK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2016

List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Michael M.T.C., Ying H., Tong S.M. and Wong I.C.K., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2016.

Cheung K.S. and Leung W.K., Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management, World Journal of Gastroenterology. 2017, 23: 1954-63.

He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observational studies, British Journal of Clinical Pharmacology. 2016, 82(1): 285-300.

Ko M.K.L., Ng S.C., Mak L.Y., Li M.K., Lo F.H., Ng C.K.M., Lao W.C., Tsang S., Chan K.H., Hui Y.T., Shan E.H.S., Loo C.K., Hui A.J., To W.P., Hung F.N.I. and Leung W.K., Infection-related Hospitalizations Within The First Year After IBD Diagnosis, Journal of Digestive Diseases. 2016, 17(9): 610-617.

Leung W.K., Chan E.W., Wong Y.S., Chen L., Wong O.L., Wong I.C. and Cheung M.K.S., Age of Helicobacter pylori Eradication and Subsequent Risk of Gastric Cancer Development: A Population-Based Study, Digestive Disease Week, 6-9 May 2017, Chicago, USA. 2017.

Leung W.K., But Y.K.D., Wong S.Y., Liu S.H.K. and Hung F.N.I., Prevention of Post-sphincterotomy Bleeding by Proton Pump Inhibitor: A Prospective Randomized Trial, 25th United European Gastroenterology Week, 15-19 Oct 2016, Vienna, Austria. 2016.

Leung W.K., Ho H.J., Lin J.T., Wu M.S. and Wu C.Y., Prior gastroscopy and mortality in patients with gastric cancer: a matched retrospective cohort study, Gastrointestinal Endoscopy. 2017.

Li T.H., Qin Y., Sham P.C., Lau K.S., Chu K.M. and Leung W.K., Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis, Scientific Reports. 2017, 7: 44935.

Lin Y.S., Seto W.K.W., Chiu W.H.K., Ren T.H., Shen X.P., Guo J.Q., Li X.F. and Leung W.K., Magnetic resonance enterography distinguishes intestinal tuberculosis from Crohn’s disease in Chinese patients with ileocecal lesions on colonoscopy, Digestive Disease Week 2017.

MA Z., Lau K.S., Law W.L. and Leung W.K., ., Comparison Of Methylated Septin 9 With Carcinoembryonic Antigen In Monitoring Of Colorectal Cancer Patients After Curative Surgery, Digestive Disease Week, Chicago, USA, 6-9 May 2017.

Mak L.Y., Ng S.C., Wong O.L., Li M.K.K., Lo F.H., Wong M.T.L., Leung C.M., Tsang S.W.C., Chan K.H., Sze S.F., Shan E.H.S., Lam E.H.S., Hui A.J., Hung F.N.I. and Leung W.K., Direct Health Care Cost Utilization in Hong Kong Inflammatory Bowel Disease Patients in the Initial 2 Years Following Diagnosis, Journal of Gastroenterology and Hepatology. 2017.

Ng L., Wan T.M.H., Man H.W., Chow K.M., Lyer D., Chen G., Yau T.C.C., Lo O.S.H., Foo C.C., Poon T.C.J., Leung W.K., Pang R.W.C. and Law W.L., Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer, Oncotarget. 2017, 8(16): 27393-27400.

Ng S.C., Leung W.K., Shi H.Y., Li M.K.K., Leung C.M., Ng C.K.M., Lo F.H., Hui Y.T., Tsang S.W.C., Chan Y.K., Loo C.K., Chan K.H., Hui A.J., Chow W.H., Harbord M., Ching J.Y.L., Lee M., Chan V., Tang W., Hung F.N.I., Ho J.W.C., Lao W.C., Wong M.T.L., Sze S.F., Shan E.H.S., Lam B.C.Y., Tong R.W.H., Mak L.Y., Wong S.H., Wu J.C.Y., Chan F.K.L. and Sung J.J.Y., Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong., Inflammatory Bowel Diseases. 2016, 22(8): 1954-1960.

Seto W.K.W., Mak S.K., Chiu W.H.K., Wong H.F., Lee S.F., Cheung K.S., Ho Y.C., Yuen R.M.F. and Leung W.K., Cholangiopathic changes related to recreational use of ketamine: a prospective clinical and radiological evaluation, Digestive Disease Week 2017.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Shi H.Y., Chan F.K.L., Leung W.K., Li M.K.K., Leung C.M., Sze S.F., Ching J.Y., Lo F.H., Tsang S.W., Shan E.H.S., Mak L.Y., Lam B.C.Y., Hui W.H., Chow W.H., Wong M.T.L., Hung F.N.I., Jui Y.T., Chan Y.K., Chan K.H., Loo C.K., Ng C.K.M., Lao W.C., Harbord M., Wu J.C.Y., Sung J.J.Y. and Ng S.C., Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry, Therapeutic Advances in Gastroenterology. 2016, 9(4): 449-456.

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

Tian L., Qiu H., SUN S., Tsang H., Chan K.P. and Leung W.K., Association between emergency admission for peptic ulcer bleeding and air pollution: a case-crossover analysis in Hong Kong's elderly population, The Lancet Planetary Health. 2017, 1: e74-81.

Ye W., Takabayashi H., Yang Y.T., Mao M.Y., Samuelson L.C., Demitrack E., Huang F.Y., Chu K.M., Leung W.K. and Todisco A., Regulation of CD44 expression by bone morphogenetic protein (BMP) signaling and inflammatory stimuli, Digestive Disease Week (DDW) 2017. Gastroenterology, 152: Gastroenterology. 2017;152(5)S86.

Researcher : Leung YH

List of Research Outputs

Cheung C.L., Leung Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C. and Tan K.C.B., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese., American Society for Bone and Mineral Research Annual Meeting, Atlanta, Sept 2016.. 2016.

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese, Thrombosis and Haemostasis. 2016, 117: 158-163.

Researcher : Li G

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Researcher : Li GR

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Researcher : Li J

List of Research Outputs

Researcher : Li LSW

List of Research Outputs

CHENG K.Y., Yiu E.M.L., Li L.S.W., CHIU M.Y., Wong C.S. and Chan K.M.K., 5hz Repetitive Transcranial Magnetic Stimulation (rtms)—effects On Cortical Excitability And Speech And Swallowing Functions In Stroke Patients., 2nd International Brain Stimulation Conference. 2017.

CHENG K.Y., Chan K.M.K., Wong C.S., Cheung R.T.F., Li L.S.W. and CHIU M.Y., Motor Evoked Potentials Of The Tongue In Healthy Adults And Dysphagic Individuals, 6th European Society for Swallowing Disorders Congress. 2016.

CHENG K.Y., Yiu E.M.L., Li L.S.W., CHIU M.Y., Wong C.S. and Chan K.M.K., Rehabilitation Of Chronic Post-stroke Dysphagia Using Repetitive Transcranial Magnetic Stimulation (rtms). , 5th China Dysphagia Summit Forum. 2017.

CHENG K.Y., Chan K.M.K., Wong C.S., Cheung R.T.F., Li L.S.W. and CHIU M.Y., Short Term Effects Of 5hz Repetitive Transcranial Magnetic Stimulation (rtms) On Swallowing And Speech Functions In Post-stroke Individuals. , 6th European Society for Swallowing Disorders Congress. 2016.

CHENG K.Y., Yiu E.M.L., Li L.S.W., CHIU M.Y., Wong C.S. and Chan K.M.K., The use of 5Hz rTMS to improve swallowing functions in chronic post-stroke dysphagia., Dysphagia Research Society 2017 Annual Meeting. 2017.

CHENG K.Y., Chan K.M.K., Wong C.S., Li L.S.W., CHIU M.Y. and Cheung R.T.F., Use of 5Hz rTMS to improve speech functions in post-stroke dysarthric patients., 39th Australasian Society for the Study of Brain Impairment Annual Brain Impairment Conference. 2016.

Researcher : Li RA

Project Title:	Cell-based Heart Regeneration
Investigator(s):	Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2011
Completion Date:	09/2017

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Establishing a Molecular Encyclopedia for Stem Cell & Regenerative Medicine: Heart
Investigator(s):	Li RA, Tam PKH, Cheung YF
Department:	Dr. Li Dak-Sum Research Centre
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 2)
Start Date:	08/2016

Researcher : Li TH

List of Research Outputs

Li T.H., Qin Y., Sham P.C., Lau K.S., Chu K.M. and Leung W.K., Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis, Scientific Reports. 2017, 7: 44935.

Researcher : Li W

List of Research Outputs

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Researcher : Li WMM

List of Research Outputs

Li W.M.M., YIM L.Y., Chan V.S.F. and Lau W.C.S., Autoimmune-associated Gene Clec16a Regulates Nlrp3 But Not Aim2 Inflammasome Pathway In Human Macrophages, Asian Congress of Autoimmunity 2017 & Lupus 2017.

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

Researcher : Li X

List of Research Outputs

Researcher : Li YV

List of Research Outputs

Lam S.K., LEUNG L.L., Li Y.V., Zheng C. and Ho J.C.M., Combination effects of arsenic trioxide and fibroblast growth factorreceptor inhibitor in squamous cell lung carcinoma, Lung Cancer. 2016, 101: 111-119.

Lam S.K., Li Y.V., XU S., LEUNG L.L., U K.P., ZHENG Y.F., CHENG P.N. and Ho J.C.M., Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts, Respiratory Research. 2017, 18(1): 80.

Researcher : Lian Q

Project Title:	The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2012

Project Title:	The Roles and Mechanisms of RAP1/NFkb signaling pathway in MSC-induced immunomodulation for organ transplantation
Investigator(s):	Lian Q, Poon MW, He J
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2013

Project Title:	Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease
Investigator(s):	Lian Q, Wong DSH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2013

Project Title:	International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Project Title:	Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):	Lian Q, Tse HF, Poon MW
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2013

Project Title:	Functional roles of human ESC/iPSC-derived mesenchymal stem cell-deposited matrixes for improving survive and functions of retinal pigment epithelial cell (RPE)
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Direct Mitochondrial Transfer of Stem Cells Restores Ocular Mitochondrial Dysfunction: The Role of NF-κB Activation
Investigator(s):	Lian Q, Wong DSH
Department:	Ophthalmology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Project Title:	Functional Roles of Procollagen 2a1 in the Regulation of Nkx2.5+Cardiac Progenitor Cells for Myocardial Regeneration
Investigator(s):	Lian Q, Zhang Y
Department:	Ophthalmology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Human induced pluripotent stem cells derived-nucleus pulposus cells for intervertebral disc degeneration in rats
Investigator(s):	Lian Q, Zhang Y, Cheah KSE
Department:	Ophthalmology
Source(s) of Funding:	AO Spine Asia Pacific
Start Date:	06/2016

Project Title:	Regulation of mitochondrial transfer potency by Kif5b in mesenchymal stem cells to rescue mitochondrial dysfunction-provoked ganglion cell degeneration
Investigator(s):	Lian Q, Huang J, Chiu K
Department:	Ophthalmology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2016

Project Title:	18th International Congress of Developmental Biology ; Generating NOTO-GFP reporter in human pluripotent stem cells for understanding notochordal development
Investigator(s):	Lian Q
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

JIANG D., GAO F., Zhang Y., Wong D.S., Li Q., Xu G., Yu Z. and Lian Q., Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage., Cell Death Dis. 2016 Nov. 2016, 7(11): e2467.

Jiang D., Gao F., Zhang Y., Wong D.S., Li Q., Tse H.F., Xu G., Yu Z. and Lian Q., Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage., Cell Death Dis. 2016. 2016, 7(11): e2467.

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Poon M.W., Jiang D., Qin P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Wong I.Y., Yu Z., Tse H.F., Wong D.S. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn., Sci Rep. 2017. 2017, 7: 41224.

Poon M.W., Jiang D., Qing P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Li Q., Wong Y.H.I., Yu Z., Tse H.F., Wong D.S.H. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn, Scientific Reports. 2017, 7: 41224.

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., ZHANG Z., Cheah K.S.E. and Lian Q., Developing Strategies to Produce Notochord Like Cells from Human ESC/iPSC, ISSCR 2017 Annual Meeting. 2017.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : Liang Q

List of Research Outputs

Jo E., Li S., Liang Q., Zhang X., Wang H., Herbert T., Jenkins T., Xu A., Ye J. and Guiliou H., Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21, PLOS ONE. 2017, 12: e0173676.

WANG Y., TSE M.A., LIU Y., Zhu C.F., Liang Q. and Xu A., High Intensity Exercise: A Multi-beneficial Exercise Modality to Promote Browning of White Adipose Tissue, Reduce Fat Accumulation and Control Metabolic Disease, 10th International Conference on Strength Training, Kyoto, Japan, November 30-December 2, 2016.

Researcher : Liang RHS

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : Liang X

List of Research Outputs

Researcher : Liang Y

List of Research Outputs

Researcher : Liao S

Project Title:	Efficacy and Safety of Human Embryonic Stem Cell-derived Cardiomyocytes in Post-Myocardial Infarction Heart Failure
Investigator(s):	Liao S, Zhu Z
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	12/2016

List of Research Outputs

Agrawal D.E.V.A.N.S.H. .R., Tanabe Y.U.J.I., Weng D.E.S.E.N., Ma A.N.D.R.E.W., Hsu S.T.E.P.H.A.N.I.E., Liao S., ZHEN Z., Zhu Z., Sun C.H.U.A.N.B.O.W.E.N., Dong Z.H.E.N.Y.A., Yang F.E.N.G.Y.U.A.N., Tse H.F., Poon A.D.A. and Ho J.O.H.N. .S., Conformal phased surfaces for wireless powering of bioelectronic microdevices, Nature Biomedical Engineering. 2017, 1: 0043.

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : Lie AKW

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Researcher : Liu F

List of Research Outputs

Researcher : Liu H

List of Research Outputs

Ho W.L., Lam C.S.C., Liu H., Leung C.T.G., LI L., Ramsden D.B. and Ho S.L., Impaired Stress-induced Mitophagy In Parkinsonian LRRK2(R1441G) Knockin Mutant Mice, 21st International Congress of Parkinson's Disease and Movement Disorders (Vancouver 2017). 2017.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Liu H., Ho W.L., Tse H.M., Pang S.Y.Y., Ramsden D.B. and Ho S.L., Leucine-rich Repeat Kinase 2 (lrrk2) Knockin Mouse Model For Pathophysiological Studies Of Parkinson's Disease (pd), Health Research Symposium 2017 (Food and Health Bureau, Hong Kong S.A.R.). 2017.

Researcher : Liu J

List of Research Outputs

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

Researcher : Liu SHK

List of Research Outputs

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Leung W.K., But Y.K.D., Wong S.Y., Liu S.H.K. and Hung F.N.I., Prevention of Post-sphincterotomy Bleeding by Proton Pump Inhibitor: A Prospective Randomized Trial, 25th United European Gastroenterology Week, 15-19 Oct 2016, Vienna, Austria. 2016.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Fung J.Y.Y., Cheung K.S., Mak L.Y., Hui R.W.H., Liu S.H.K., Lai C.L. and Yuen R.M.F., Body-mass index is associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B., Alimentary Pharmacology and Therapeutics. 2016, 44: 1071-1079.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

Yuen R.M.F., Liu S.H.K., Chan H.L.Y., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lau J.Y., Ferrari C. and Gish R.G., Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S27.

Researcher : Liu WKK

Project Title:	Effects of aging on cigarette smoke-induced inflammation in airway epithelial cells
Investigator(s):	Liu WKK, Mak JCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

List of Research Outputs

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Best Oral Presentation Award on Basic Science, 22nd Medical Research Conference (MRC), HKU. Hong Kong, Hong Kong Academy of Medicine Press, 2017, 23 (Supplement 1): 17.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Cigarette smoke medium induces apoptosis via the translocator protein (TSPO) in airway epithelial cells, American Thoracic Society (ATS) International Conference 2017, Am J Respir Crit Care Med . USA, ATS, 2017, 195: A6297.

CUI Y., Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells, Toxicology Letters. 2017, 268: 44-50.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Selegeline suppressed cigarette smoke medium (CSM)-induced oxidative stress, inflammation and apoptosis via monoamine oxidase-B inhibition in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 17.

Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Differential inflammatory responses resulted from cellular senescence induced by doxorubicin and antimycin in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J . Hong Kong, HK Academy of Medicine Press, 2017, 23: 33.

Researcher : Liu Y

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Lui MSM

List of Research Outputs

Kwok W.C., Tam C.C.T., Lui M.S.M., Lam C.L.D. and Ho J.C.M., Control of brain metastases with alectinib in anaplastic lymphoma kinase-rearranged lung cancer, Respirology Case Reports. 2017, 5(3): e00224.

Researcher : Lui SL

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Researcher : MA Z

List of Research Outputs

MA Z., Lau K.S., Law W.L. and Leung W.K., ., Comparison Of Methylated Septin 9 With Carcinoembryonic Antigen In Monitoring Of Colorectal Cancer Patients After Curative Surgery, Digestive Disease Week, Chicago, USA, 6-9 May 2017.

Researcher : Ma CH

Project Title:	The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms
Investigator(s):	Ma CH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Generating transgenic zebrafish model to study the emerging role of autophagy and mitophagy in hematopoietic diseases
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Researcher : Ma KMM

List of Research Outputs

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Mak JCW

Project Title:	Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):	Mak JCW, Chan MMW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2005

Project Title:	Therapeutic Potential of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells (hiPSC-MSCs) on oxidative stress-induced
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	The effect of cigarette smoke on the regulation of lipocalin 2 in airway cells in vitro and in vivo – relevant to chronic obstructive pulmonary disease
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015
Completion Date:	11/2016

Project Title:	Role of Dendrobium officinale polysaccharides in amelioration of cigarette smoke-induced mucus hypersecretion – relevant to chronic obstructive pulmonary disease
Investigator(s):	Mak JCW, Zhang Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Best Oral Presentation Award on Basic Science, 22nd Medical Research Conference (MRC), HKU. Hong Kong, Hong Kong Academy of Medicine Press, 2017, 23 (Supplement 1): 17.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Cigarette smoke medium induces apoptosis via the translocator protein (TSPO) in airway epithelial cells, American Thoracic Society (ATS) International Conference 2017, Am J Respir Crit Care Med . USA, ATS, 2017, 195: A6297.

CUI Y., Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells, Toxicology Letters. 2017, 268: 44-50.

CUI Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Selegeline suppressed cigarette smoke medium (CSM)-induced oxidative stress, inflammation and apoptosis via monoamine oxidase-B inhibition in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 17.

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Liang Y., Ip M.S.M. and Mak J.C.W., The 3rd Prize for Outstanding Poster Presentation, 20th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. Hong Kong, Journal of the Hong Kong College of Cardiology, 2016, 24: 86.

Lim T.K., Ko F.W.S., Benton M.J., Berge M.V. and Mak J.C.W., Year in review 2016: Chronic obstructive pulmonary disease and asthma, Respirology. 2017, 22: 820-828.

Liu W.K.K., Liang Y., Ip M.S.M. and Mak J.C.W., Differential inflammatory responses resulted from cellular senescence induced by doxorubicin and antimycin in airway epithelial cells, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J . Hong Kong, HK Academy of Medicine Press, 2017, 23: 33.

WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-intensity intermittent hypoxia promotes subcutaneous adipogenic differentiation, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 44.

ZHANG P., Mak J.C.W., Man R.Y.K. and Leung S.W.S., Effects of genistein on inflammatory responses in cigarette smoke-exposed rats, Pharmacology 2016, The Queen Elizabeth II Conference Centre, London, 13-15 December, 2016.

Researcher : Man CH

List of Research Outputs

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : Mok MY

List of Research Outputs

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Fang X.H.B., Choy C.B.Y. and Chan D.T.M., Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient, Journal of the Formosan Medical Association. 2017, Epub ahead of print.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Mok MYT

Project Title:	The role of IL-33 in the modulation of macrophage differentiation and immunoregulatory functions in systemic lupus erythematosus
Investigator(s):	Mok MYT, Lau WCS, Chan GCF, Chan KW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	07/2016

Project Title:	Working towards better oral health and dental care for underprivileged patients with chronic inflammatory arthritis
Investigator(s):	Mok MYT, Leung KCM, Chow MK
Department:	Medicine
Source(s) of Funding:	Health Care and Promotion Fund - Research Grant Projects
Start Date:	08/2015
Completion Date:	10/2016

List of Research Outputs

Golder V., Kandane-Rathnayake R., Hoi A.Y.B., Huq M., Louthrenoo W., An Y., Li Z.G., Luo S.F., Sockalingam S., Lau W.C.S., Lee A.L., Mok M.Y.T., Lateef A., Franklyn K., Morton S., Navarra S.T.V., Zamora L., Wu Y.J., Hamijoyo L., Chan M., O’Neill S., Goldblatt F., Morand E.F. and Nikpour M., Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort, Arthritis Research & Therapy. 2016, 18.

Ng L.K.A., Choy N.K.B., Chan T.C.Y., Wong Y.H.I., Lai J.S.M. and Mok M.Y.T., Comparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome, Cornea. 2017, 1.

XU X., Hui S.K., Mok M.Y.T., Jiang J., Lau W.C.S. and Mak H.K.F., Structural Brain Network Reorganization in Patients with Neuropsychiatric Systemic Lupus Erythematosus, American Journal of Neuroradiology. 2016.

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553.

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017.

Researcher : Mok TMY

Project Title:	The role of IL-33 in the modulation of macrophage differentiation and immunoregulatory functions in systemic lupus erythematosus
Investigator(s):	Mok MYT, Lau WCS, Chan GCF, Chan KW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	07/2016

Project Title:	Working towards better oral health and dental care for underprivileged patients with chronic inflammatory arthritis
Investigator(s):	Mok MYT, Leung KCM, Chow MK
Department:	Medicine
Source(s) of Funding:	Health Care and Promotion Fund - Research Grant Projects
Start Date:	08/2015
Completion Date:	10/2016

List of Research Outputs

Researcher : NG KL

List of Research Outputs

He B.A., LAM S.Y., CHER C.Y., NG K.L. and Leung A.Y.H., Follistatin is a critical mediator for FLT3/ITD+ acute myeloid leukemia, Experimental Hematology. 2016, 44: S79.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : NG YM

List of Research Outputs

Kukalev A., NG Y.M., JU L., Saidi A., Lane S., Mondragon A., Dormann D., Walker S.E., Grey W., Ho W.L., Stephens D.N., Carr A.N., Kamsa K., Tse E.W.C. and YU V.P., Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates, Cerebral Cortex. 2017, 27: 11-23.

Researcher : NING Z

List of Research Outputs

SUN T., LI C., Xiong L., NING Z., Leung F.K.L., PENG S.L. and Lu W.W., miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and beta-catenin, PLOS ONE. 2017, 12(2).

Researcher : Ng CL

Project Title:	Adiponectin deficiency elicits neuroinflammation by overwhelmed microglia activation causing Alzheimer's disease and synaptic loss in aged mice
Investigator(s):	Ng CL, Chan KH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	Small molecule of Adiponectin receptor agonist, AdipoRon - a potential therapeutic medication for Alzheimer's disease
Investigator(s):	Ng CL, Chan KH, Chung SK
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	AD/PD 2017: the 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders; Adiponectin Protects Against Amyloid Deposition And Toxicity Through Cerebral Insulin Sensitization In Alzheimer's Disease Mouse Model
Investigator(s):	Ng CL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017
Completion Date:	04/2017

List of Research Outputs

Chan K.H., Ng C.L. and Yick L.W., Immunopathological Effects Of Aquaporin-4 IgG In Neuromyelitis Optica Spectrum Disorders, MOJ Immunology. 2017, 5(5): 00168.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Ng C.L. and Chan K.H., Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease, In: Katalin Prokai-Tatrai, International Journal of Molecular Sciences. 2017, 18: 592.

Researcher : Ng KM

Project Title:	Novel Therapeutic Approach for X-linked related Danon Disease Insight from Patient-specific Pluripotent Stem Cells Platform.
Investigator(s):	Ng KM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Pathological contribution of lysosomal instability in LAMP2-deficiency induced neural dysfunction
Investigator(s):	Ng KM, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

Researcher : Ngai WS

List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Researcher : PAN Y

List of Research Outputs

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Shu L., WU X., PAN Y., CHEONG L.Y., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) modulates adaptive thermogenesis by enhancing intracellular activation of thyroid hormones in brown adipocytes, 2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of KSSO . 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Vanhoutte P.M.G.R., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clinical Science. 2016.

Researcher : PANG YT

List of Research Outputs

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

Researcher : PIAO W

List of Research Outputs

PIAO W., Chau H.W.D., Yue L.M., Kwong Y.L. and Tse E.W.C., Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma, Leukemia. 2017, 31: 522-526.

Researcher : Pai MCP

List of Research Outputs

Li X.-.Y., Liang Y.-.S. and Pai M.C.P., The transition of renal histopathology after immunosuppressive therapy in a woman with renal limited ANCA-associated vasculitis. A case report and literature review., In: X-Y Li, Y-S Liang, P Pai. , Clin and Experimental Rheum. 2016, 2016; 34: S115-120.

Pai M.C.P. and Pai M.C.P., A haemodialysis Journey from the West to the East, In: P Pai, Kidney Diseases. 2016, 2016; 2: 88-94.

Pai M.C.P., stadardised specialist training in the U.K. and its application in HKU-SZH, Ningbo University School of Medicine. 2016.

Researcher : Pang HK

List of Research Outputs

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Researcher : Pang SYY

List of Research Outputs

Cheung R.T.F., Xiong L., Chang S.K.R., Tse C.T.A., Pang S.Y.Y., Mok V., Leung T., Tsoi T.H., Li R., Mok M., Chang C.M., Lau K.K., Sheung B., Li T., Yeung J., Leung P.C., Chook P. and Wong K.S., Herbs and Rehabilitation after Stroke Study: A Multi-center, Double-blinded, Randomized Trial in Hong Kong, Journal of Stroke. 2016, 18: 361-363.

Liu H., Ho W.L., Leung C.T.G., Lam C.S.C., Pang S.Y.Y., LI L., Kung M.H.W., Ramsden D.B. and Ho S.L., Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease, Scientific Reports. 2017, 7: 40887.

Liu H., Ho W.L., Tse H.M., Pang S.Y.Y., Ramsden D.B. and Ho S.L., Leucine-rich Repeat Kinase 2 (lrrk2) Knockin Mouse Model For Pathophysiological Studies Of Parkinson's Disease (pd), Health Research Symposium 2017 (Food and Health Bureau, Hong Kong S.A.R.). 2017.

Researcher : Poon MW

List of Research Outputs

Poon M.W., Jiang D., Qin P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Wong I.Y., Yu Z., Tse H.F., Wong D.S. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn., Sci Rep. 2017. 2017, 7: 41224.

Poon M.W., Jiang D., Qing P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Li Q., Wong Y.H.I., Yu Z., Tse H.F., Wong D.S.H. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn, Scientific Reports. 2017, 7: 41224.

Researcher : RAN X

List of Research Outputs

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

Researcher : SHU L

List of Research Outputs

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein (A-FABP) in obesity and its related complications: Friend or Foe?, 4th Lingnan International Symposium of Metabolic Diseases: Frontiers in Immunometabolism. 2017.

Shu L., WU X., PAN Y., CHEONG L.Y., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) modulates adaptive thermogenesis by enhancing intracellular activation of thyroid hormones in brown adipocytes, 2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of KSSO . 2016.

WU X., Shu L., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of liver fibrosis, FASEB Science Research Conference. 2017.

Zhou M., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP)is a potential mediator of heart dysfunction and failure related to obesity, the 11th International Diabetes Federation Western Pacific Region Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes in Taipei, Taiwan . 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Vanhoutte P.M.G.R., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clinical Science. 2016.

Researcher : Seto WKW

Project Title:	Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure
Investigator(s):	Seto WKW, Kwong YL, Lie AKW, Wong DKH, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2013
Completion Date:	10/2017

Project Title:	Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B
Investigator(s):	Seto WKW, Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2014

Project Title:	Provision of Controlled Attenuated Parameter Measurements for the Identification of Non-Alcoholic Fatty Liver Disease and Disease Monitoring of Liver Cirrhosis
Investigator(s):	Seto WKW, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Proteomic screening for potential protein biomarker(s) associated with spontaneous HBsAg seroclearance in patients with chronic hepatitis B infection
Investigator(s):	Seto WKW, Wong DKH, Huang FY, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Metabolic determinants of fibrosis reversal in advanced chronic hepatitis B during long-term nucleoside analogue therapy
Investigator(s):	Seto WKW, Lam KSL, Yuen RMF, Wong DKH, Fung JYY, Lee CHP
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

List of Research Outputs

Buti M., Gane E., Seto W.K.W., Chan H.L., Chuang W.L., Stepanova T., Hui A.J., Lim Y.S., Mehta R., Janssen H., Acharya S.K., Flaherty J., Massetto B., Cathcart A.L., Kim K., Gaggar A., Subramanian G.M., McHutchison J., Pan C., Brunetto M., Izumi N. and Marcellin P., Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial, The Lancet Gastroenterology & Hepatology. 2016, 1: 196-206.

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chan H.L., Tsang O.T., Hui Y.T., Fung J.Y.Y., Lui G.C., Lai C.L., Wong G.L., Chan K.H., But Y.K.D., Lai M.S., Lao W.C., Chan C., Lam Y.S., Seto W.K.W., Li C., Yuen R.M.F. and Wong V.W., Real-Life Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir in Chronic Hepatitis C Patients in Hong Kong, Journal of Gastroenterology and Hepatology. 2016, 32(6): 1230-33.

Chan H.L., Fung S., Seto W.K.W., Chuang W.L., Chen C.Y., Kim H.J., Hui A.J., Janssen H., Chowdhury A., Tsang T.Y., Rajiv M., Gane E., Flaherty J., Massetto B., Gaggar A., Kitrinos K.M., Lin L., Subramanian G.M., McHutchison J., Lim Y.S., Acharya S.K. and Agarwal K., Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial, The Lancet Gastroenterology & Hepatology. 2016, 1: 185-195.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of primary biliary cholangitis in Hong Kong: Results from the public healthcare system database from 2000 to 2015. [Poster presentation, Hepatology 2016; 64(S1):198A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., High level of Wisteria floribunda agglutinin-positive human Mac-2 binding protein is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral treatment. Oral Presentation, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11 (Suppl 1): S72.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Predictive factors of hepatocellular carcinoma and transplant-free survival in Chinese patients with primary biliary cholangitis. [Poster presentation, Hepatology 2016; 64(S1):678A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid, Clin Transl Gastroenterol. 2017, 8(6): e100.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic factors for transplant-free survival and external validation of prognostic models in Chinese patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S544.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy, J Viral Hepat. 2017, 24(8): 654-61.

Cheung K.S., Seto W.K.W., Wong D.K.H., Mak L.Y., Lai C.L. and Yuen R.M.F., Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment, Oncotarget. 2017, 8(29): 47507-17.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Sin S.L., Ma K.W., Ng K.C.K., Ng K.C.K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Long Term Outcomes of Entecavir Monotherapy for Chronic Hepatitis B after Liver Transplantation: Results up to 8 years, Hepatology. 2017, 66(4): 1036-44.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Ng K.C.K., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L. and Yuen R.M.F., No increase in graft fibrosis for hepatitis B surface antigen positive patients after liver transplantation using entecavir monotherapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL). Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S184-S185.

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Li J., Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of IL-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection. [Poster presentation, Hepatology 2016; 64(S1):877A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Li J., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver Int. 2017, 37(9): 1287-94.

Lin Y.S., Seto W.K.W., Chiu W.H.K., Ren T.H., Shen X.P., Guo J.Q., Li X.F. and Leung W.K., Magnetic resonance enterography distinguishes intestinal tuberculosis from Crohn’s disease in Chinese patients with ileocecal lesions on colonoscopy, Digestive Disease Week 2017.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Mak L.Y., Seto W.K.W., Hui R., Fung J.Y.Y., Cheung K.S., Lai C.L. and Yuen R.M.F., Nucleos(t)ide analogue decreased liver stiffness of e-antigen negative chronic hepatitis B (CHB) patients over a 10-year interval, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S251.

Seto W.K.W. and Yuen R.M.F., "Immune tolerance" in HBV infection: danger lurks, Nature Reviews in Gastroenterology and Hepatology. 2016, 13: 627-628.

Seto W.K.W., Adverse effects of proton-pump inhibitors, Multi-hospital Gastroenterology Conference, HKUSZH, Shenzhen. 2017.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Best of AASLD 2016, Hong Kong Association for the Study of Liver Disease and Wiley Hong Kong. 2017.

Seto W.K.W., Fung J.Y.Y., Cheung K.S., Mak L.Y., Hui R.W.H., Liu S.H.K., Lai C.L. and Yuen R.M.F., Body-mass index is associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B., Alimentary Pharmacology and Therapeutics. 2016, 44: 1071-1079.

Seto W.K.W., Mak S.K., Chiu W.H.K., Wong H.F., Lee S.F., Cheung K.S., Ho Y.C., Yuen R.M.F. and Leung W.K., Cholangiopathic changes related to recreational use of ketamine: a prospective clinical and radiological evaluation, Digestive Disease Week 2017.

Seto W.K.W., Chronic hepatitis B: enhancing treatment response, Multi-specialty Medical Mega Conference. Association of Private Medical Specialists. 2017.

Seto W.K.W., Colon cancer screening: time to commence, 4th HKU-Shenzhen Medical Forum, Shenzhen, China,. 2016.

Seto W.K.W., DAA for chronic HCV infection: difficult to treat cases, HCVie Grand Round Meetings, Amsterdam, Netherlands. 2017.

Seto W.K.W., Direct acting antivirals for hepatitis C: local data, Hong Kong Association for the Study of Liver Disease Annual Scientific Meeting. 2016.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Seto W.K.W., Health highlight of the day: Hepatitis C can be asymptomatic and be dormant for many years, Hong Kong Economic Journal. 2017.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Seto W.K.W. and Yuen R.M.F., Hepatitis B virus reactivation during immunosuppressive therapy, In: Griffin M, Immunosuppressives: advancements, applications and analyses. Nova Science, 2017, 41-82.

Seto W.K.W. and Yuen R.M.F., Letter: is body-mass index really associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B? Authors' reply, Aliment Pharmacol Ther. 2017, 45(3): 483.

Seto W.K.W., Management of chronic hepatitis C: in the new era of DAA, 4th International Hepatology Conference, Dhaka, Bangladesh. 2016.

Seto W.K.W. and Yuen R.M.F., New pharmacological approaches to a functional cure of hepatitis B, Clinical Liver Disease. 2016, 8: 83-88.

Seto W.K.W. and Yuen R.M.F., Non-alcoholic fatty liver disease: emerging perspectives, Journal of Gastroenterology. 2017, 52(2): 164-74.

Seto W.K.W., Non-invasive assessment of liver fibrosis and steatosis, 11th Global Gastroenterologists Meeting, Rome, Italy. 2017.

Seto W.K.W., Asahina Y., Peng C.Y., Stanciu C., Abdurakhmanov D., Flaherty J., Kim K., Gaggar A., Subramanian M., Tabak F., Nguyen T.T. and Chan H.L.Y., Reduced Changes in Bone Mineral Density in Chronic HBV (CHB) Patients Receiving Tenofovir Alafenamide (TAF) Compared With Tenofovir Disoproxil Fumarate (TDF), Liver Meeting, The American Association for the Study of the Liver. 2016.

Seto W.K.W., Asahina Y., Peng C.Y., Stanciu C., Abdurakhmanov D., Flaherty J., Kim L., Gaggar A., Subramanian M., Tabak F., Nguyen T.T. and Chan H.L.Y., Reduced Changes in Bone Mineral Density in chronic hepatitis B Patients Receiving TAF Compared with TDF, The Asia Pacific Association for the Study of the Liver. 2017.

Seto W.K.W. and Yuen R.M.F., Response to Toyoda et al, Am J Gastroenterol. 2017, 112(6): 970.

Seto W.K.W., Rifaximin for cirrhosis: optimized management, Round-table expert panel meeting, Guangzhou, China,. 2016.

Seto W.K.W., Roundtable Discussion on HBV Screening Recommendations prior to the use of Biologic Agents for Rheumatic Diseases in Hong Kong, Hong Kong Society of Rheumatology Meeting. 2017.

Seto W.K.W., The breakthrough of chronic hepatitis C management – first pangenotypic approach for different patients, Omnihealth Practice. 2017, 4: 10-15.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Yap Y.H.D., Seto W.K.W., Fung J.Y.Y., Chok K.S.H., Chan S.C., Chan G.C.W., Yuen R.M.F. and Chan T.M., Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis, Digestive and Liver Disease. 2016, 49(2): 202-206.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Shen J

Project Title:	Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):	Shen J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Project Title:	Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions
Investigator(s):	Shen J, Yang D, Chen X
Department:	School of Chinese Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Exploration of dietary compound isoliquiritigenin in chemosensitizing breast cancer stem cells by targeting aberrant β–catenin signalling
Investigator(s):	Shen J, Chen J, Wang Z
Department:	School of Chinese Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural stem/progenitor cells through activating Notch signaling pathway
Investigator(s):	Shen J, So KF, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Exploring Caveolin-1 as a Novel Molecular Target for Hampering T lymphocytes Infiltration through Blood Brain Barrier and Attenuating Disease Progress in Experimental Autoimmune Encephalomyelitis
Investigator(s):	Shen J, Chan GCF, Wu W
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Elucidating the role of HMGB1in blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):	Shen J, Chen X, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	Exploring the neuroprotective effect and toxickinetics of An-Gong-Niu-Huang Wan in ischemic rat stroke model
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	03/2015
Completion Date:	12/2016

Project Title:	Exploring HMGB1 signaling as molecular target in peroxynitrite-mediated blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):	Shen J, Yang D, Chung SK
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Elucidating Impacts of Reactive Nitrogen Species-mediated Excessive Mitophagy on Cerebral Ischemic-Reperfusion Injury and Exploring the Neuroprotective Mechanisms of Naringin for Inhibition of Excessive Mitophagy
Investigator(s):	Shen J, Chen X
Department:	School of Chinese Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Exploring Effects of Glycyrrhizin, an Active Compound from Glycyrrhizae Radix, on Attenuating Delayed Tissue-plasminogen Activator (t-PA) Treatment-induced Hemorrhagic Transformation in Ischemic Stroke
Investigator(s):	Shen J, Chen X, Fung ML, Chen H
Department:	School of Chinese Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Evaluating the neuroprotective effect and safety of An-Gong-Niu-Huang Wan and its ingredients in ischemic stroke
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	06/2016

Researcher : Shih AZL

List of Research Outputs

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Researcher : Shiu SWM

List of Research Outputs

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in type 2 diabetes mellitus. , 11th International Diabetes Federation Western Pacific Region Congress, Taipei, Oct 2016.. 2016.

Tan K.C.B., Shiu S.W.M. and Wong Y., Association between Serum Galectin-3 and Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 77th Scientific Sessions, San Diego, June 2017.. 2017.

Tan K.C.B., Shiu S.W.M. and Wong Y., Carbamylation of HDL in type 2 diabetes mellitus. , 52nd European Association for the Study of Diabetes Annual Meeting, Sept 2016, Munich, Germany.. 2016.

Researcher : Shu L

List of Research Outputs

Researcher : Sim PYJ

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

Researcher : Singh GHH

Project Title:	Mechanisms of leukaemic transformation from myelodysplastic syndromes (MDS) failing treatment with demethylating agents.
Investigator(s):	Singh GHH, Kwong YL, Leung AYH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Determination of Prognosis in Patients with Myelofibrosis Using Novel Molecular Markers
Investigator(s):	Singh GHH, Kwong YL, So JCC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2016

Project Title:	Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide
Investigator(s):	Singh GHH
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Sin K.M., Ho S.K.D., Wong B.Y.K., Singh G.H.H., Khong P.L. and Lee E.Y.P., Beyond the lymph nodes: FDG-PET/CT in primary extranodal lymphoma, Clinical Imaging. 2017, 42: 25-33.

Singh G.H.H., Best Abstract Award in Clinical Medicine, 22nd Medical Research Conference, Department of Medicine, HKU.. 2017.

Singh G.H.H., Ip H.W., Yip S.F., Kho C.S.B., Lee K.K.H., Mak V., Lau J.S.M., Lau C.K., Lin S.Y., Wong S.M.R., Wa L.I. and Kwong Y.L., Clofarabine, Cytarabine And Mitoxantrone (CLAM) for relapsed or refractory acute myeloid leukaemia - interim results of a prospective phase 2 study, 22nd Congress of the European Haematology Association. 2017.

Singh G.H.H., Current prognostication and management of MDS and MPN, MDS Expert Meeting, Hong Kong Society of Haematology Monthly Scientific Meeting.. 2017.

Singh G.H.H., Evolving Management in MPN, National Hematology Scientific Meeting, Kuala Lumpur, Malaysia. 2016.

Singh G.H.H., Wong R.S.M. and Kwong Y.L., From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag, Therapeutic Advances in Hematology. 2017, 204062071769357.

Singh G.H.H., How We Treat MF - Clinical Experience of Chinese Population?, 2017 Joint Annual Congress of HST and TBMT HST-EHA Joint Symposium and Special Lecture Taiwan and Japan Hematology Forum. 2017.

Singh G.H.H., MDS clinical management and research in Hong Kong, MDS Experts Meeting 2016. 2016.

Researcher : Siu DCW

Project Title:	Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):	Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	Fabrication of Bio-artificial Atrio-Ventricular Node for Biological Pacing combining 3D Bio-printing and Induced Pluripotent Stem Cell Technology
Investigator(s):	Siu DCW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

List of Research Outputs

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Chan P.H.M., Wong C.K., Poh Y.C., Pun L., Leung W.W., Wong Y.F., Wong M.M., Poh M.Z., Chu D.W. and Siu D.C.W., Diagnostic Performance of a Smartphone‐Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting, Journal of the American Heart Association. 2016, 5: e003428.

Chan P.H.M., Wong C.K., Pun L., Wong Y.F., Wong M.M., Chu D.W. and Siu D.C.W., Diagnostic performance of an automatic blood pressure measurement device, Microlife WatchBP Home A, for atrial fibrillation screening in a real-world primary care setting, BMJ Open. 2017, 7: e013685.

Chan P.H.M., Wong C.K., Pun L., Wong Y.F., Wong M.M., Chu D.W. and Siu D.C.W., Head-to-Head Comparison of the AliveCor Heart Monitor and Microlife WatchBP Office AFIB for Atrial Fibrillation Screening in a Primary Care Setting, Circulation. 2017, 135: 110-112.

Chan P.H.M. and Siu D.C.W., Letter by Chan and Siu Regarding Article, “Use of Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation Who Have a History of Intracranial Hemorrhage”, Circulation. 2016, 134: e226-e227.

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Hai S.H.J.J., Wong C.K., Chan P.H.M., Tse H.F., Yung T.C. and Siu D.C.W., Quinidine for Brugada syndrome: Panacea or poison?, HeartRhythm Case Rep.. 2016, 2(6): 486-490.

He Y.H., Wong I.C.K., Li X., Anand S., Leung W.K., Siu D.C.W. and Chan E.W., The association between non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observational studies, British Journal of Clinical Pharmacology. 2016, 82(1): 285-300.

LAU C.Y., Chan E.W., Cheung C.L., SING C.W., Man K.C.K., Lip G.Y.H., Siu D.C.W., Lam K.Y.J., Lee C.H.A. and Wong I.C.K., Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation, JAMA. 2017, 317: 1151.

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

Reyes E.B., Ha J.W., Firdaus I., Ghazi A.M., Phrommintikul A., Sim D., Vu Q.N., Siu D.C.W., Yin W.H. and Cowie M.R., Heart failure across Asia: Same healthcare burden but differences in organization of care, Int J Cardiol.. 2016, 223: 163-167.

Siu D.C.W., 2016 Interviewee, Best Solution Co Limited《Introduction to the diagnosis and treatment for patients with Atrial Fibrillation for general practitioners》, 2016.

Siu D.C.W., 2016 Interviewee, Commercial Radio, Asia-Pacific AF Awareness Month 2016, 2016.

Siu D.C.W., 2016 Interviewee, Now TV- Cardiovascular conditions caused by marathon, 2016.

Siu D.C.W., 2016 Interviewee, TVB- Diabetes and heart disease, 2016.

Siu D.C.W., 2016 Invited Speaker, Jiangxi Province Rhythm Society, Nanchang, China “Asian Strategy for stroke prevention in AF.”, 2016.

Siu D.C.W., 2016 Invited Speaker, Macau Cardiology Association 2016, Macau - Annual Scientific Meetings 2016, “Diuretics and aquaretic strategy for acute decompensation heart failure”, 2016.

Siu D.C.W., 2016 Invited Speaker, SPAF Forum 2016, Macau: “HK Real world local evidence in the efficacy and safety of NOACs in SPAF, SPAF Forum 2016, Macau:. 2016.

Siu D.C.W., 2016 Invited Speaker, SPAF Forum 2016, Macau: “HK real-world local evidence in the efficacy and safety of NOACs in SPAF.”, 2016.

Siu D.C.W., 2017 CardioRhythm 2017- Press Conference and Group Interview, ”New Cardio Treatment”, 2017.

Siu D.C.W., 2017 CardioRhythm Press Conference: “New Cardio Treatment”, 2017.

Siu D.C.W., 2017 Hong Kong College of Cardiology,”港響應國際醫學界推動心房顫動普查籲為高危人士「把脈」助及早確診”, 2017.

Siu D.C.W., 2017 Interviewee, AF Book interview, ”Sharing of the results of local community screening of atrial fibrillation and patient cases”, 2017.

Siu D.C.W., 2017 Interviewee, MIMS “ Heart Failure”, 2017.

Siu D.C.W., 2017 Interviewee, Medical Bulletin“ Novel Therapeutic Targets for Heart Failure”, 2017.

Siu D.C.W., 2017 Interviewee, Omnipres, ”The unprecedented breakthrough for PCSK9 inhibitor FOURIER trial reveals evolocumab’s cardiovascular benefit”, 2017.

Siu D.C.W., 2017 Interviewee, RTHK Radio “ Heart Failure”, 2017.

Siu D.C.W., 2017 Invited Speaker, , Guangdong Atrial Fibrillation Forum, China: “Insights on PIONEER-AF PCI Study”, 2017.

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Wong C.K., Chan P.H.M. and Siu D.C.W., Letter by Wong et al Regarding Article, “Pregnancy and the Risk of Aortic Dissection or Rupture: A Cohort-Crossover Analysis”, Circulation. 2017, 135: e780-e781.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Siu SC

List of Research Outputs

Luk A.O.Y., Hui E.M.T., Sin M.C., Yeung C.Y., Chow W.S., Ho A.Y.Y., Hung H.F., Kan E., Ng C.M., So W.Y., Yeung C.K., Chan K.S., Chan K.W., Chan P.F., Siu S.C., Tiu S.C., Yeung T.F., Chan J.C.N., Chan F.W.K., Chan C., Cheung N.T., Ho S.T., Lam K.S.L., Yu L.W.L., Chao D. and Lau I.T., Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database, Diabetes Care. 2017, 40: 928-935.

Wong C.K.H., Siu S.C., Wong K.W., Yu Y.T.E. and Lam C.L.K., Effectiveness and cost-effectiveness of a two-year short messaging service (SMS) intervention for professional drivers with pre-diabetes, The 2017 ISPOR 22nd Annual International Meeting, Boston, US, 20-24 May 2017. 20 (5): A170.

Researcher : Sung YJC

List of Research Outputs

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

Researcher : TAM CY

List of Research Outputs

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

Yan S., Yim L.Y., Tam C.Y., Chan W.K., Lu L., Lau W.C.S. and Chan V.S.F., MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice, International Journal of Molecular Sciences. 2016, 17: 1282.

Researcher : TSOI MF

List of Research Outputs

Cheung C.L., Ho D.K., SING C.W., TSOI M.F., CHENG K.F., LEE K.Y., Ho Y.N. and Cheung B.M.Y., Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese, Scientific Reports. 2017, 7: 41084.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., . Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., . Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomised controlled trials of new antidiabetic drugs., Presented at the 25th Annual Scientific Congress of the Hong Kong College of Cardiology, 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: Meta-analysis of randomized controlled trials, International Journal of Cardiology. 2016, 220: 895-900.

FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and network meta-analysis of randomised controlled trials., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: network meta-analysis of randomised controlled trials. ., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016. Young Investigator Award. 2016.

FEI Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Optimal systolic blood pressure target for hypertensive patients: a network meta-analysis., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung B.M.Y. and Cheung T.T., High dose insulin for treatment of calcium channel blocker overdose: a case series., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Chu C.H.A., Cheung T.T. and Cheung B.M.Y., Hyperlipidemic effect of janus kinase inhibitors: a meta-analysis., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

TSOI M.F., Cheung T.T., Lam M.P.S. and Cheung C.L., Safety of colchicine for gout: a ten-year survey of the Hong Kong population., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

TSOI M.F., Cheung T.T. and Cheung B.M.Y., Treatment of calcium channel blocker overdose: a case series., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Researcher : Tam CC

List of Research Outputs

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Researcher : Tam CCT

List of Research Outputs

Kwok W.C., Tam C.C.T., Lui M.S.M., Lam C.L.D. and Ho J.C.M., Control of brain metastases with alectinib in anaplastic lymphoma kinase-rearranged lung cancer, Respirology Case Reports. 2017, 5(3): e00224.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Researcher : Tam CY

List of Research Outputs

Researcher : Tam S

List of Research Outputs

Li L., Zhang Q., Yang H., Zou Q., Lai C., Jiang F., Zhao P., Luo Z., Yang J., Chen Q., Wang Y., Newsome P.N., Frampton J., Maxwell P.H., Li W., Chen S., Wang D., Siu T.S., Tam S., Tse H.F., Qin B., Bao X., Esteban M.A. and Lai L., Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1., J Biol Chem. 2017, 292(11): 4755-4763.

Li R.H.W., Lam K.S.L., Tam S., Shek A.C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum Vitamin D Concentration Is Independently Associated With Anti-mullerian Hormone Level And Obesity Measures In Hong Kong Chinese Women With Polycystic Ovary Syndrome, 17th International Congress of Endocrinology cum 15th Annual Meeting of Chinese Society of Endocrinology. 2016.

Researcher : Tan KCB

Project Title:	Genetic Screening of Familial Hypercholesterolemia in Hong Kong
Investigator(s):	Tan KCB, Yeung CY, Siu DCW, Leung YYJ, Pang HK, Cheung CL
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	10/2017

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Cheung C.L., Leung Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C. and Tan K.C.B., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese., American Society for Bone and Mineral Research Annual Meeting, Atlanta, Sept 2016.. 2016.

Cheung C.L. and Tan K.C.B., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese., Thromb Haemost.. 2017, 117(1): 158-163.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Chung A.Y., Anand S., Wong I.C.K., Tan K.C.B., Wong C.F., Chui C.M.W. and Chan E.W., Improving medication safety and diabetes management in Hong Kong: a multidisciplinary approach, Hong Kong Medical Journal. 2017, 23(2): 158-67.

Chung A.Y.S., Anand S., Wong I.C.K., Tan K.C.B., Wong F.F.C., Chui C.M.W. and Chan E.W., Improving medication safety and diabetes management in Hong Kong – A multi-disciplinary approach., Hong Kong Med. J. . 2017, 23(2): 158-167.

Jiao F., Wong C.K.H., Tang S.C.W., Fung S.C.C., Tan K.C.B., McGhee S., Gangwani R.A. and Lam C.L.K., Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong, Diabetic Medicine. 2017, 34 (9): 1276–1283.

Jiao F., Wong C.K.H., Gangwani R.A., Tan K.C.B., Tang S.C.W. and Lam C.L.K., Heath-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications., Health Qual Life Outcomes. 2017, 15(1): 125.

LEUNG Y.H., Cheung B.M.Y., Nguyen U.S., Kung A.W.C., Tan K.C.B. and Cheung C.L., Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese, Bone. 2017, 97: 293-298.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lam T.H., Li W.H.C., Wang M.P., Cheung T.Y., Cheung Y.T.D., Ho K.Y., Tan K.C.B. and Chan S.S.C., A brief, tailored smoking cessation intervention for smokers with diabetes mellitus in Hong Kong, Hong Kong Medical Journal. 2017, 23(Suppl 2): S10-11.

Lam T.H., Li W.H.C., Leung Y.M.A., Tan K.C.B. and Wong C.N., A randomized controlled trial of a tailored intervention compared to usual care to promote smoking cessation and improve glycaemic control on type 2 diabetic patients who smoked (poster and abstract), Health Research Symposium 2017, June 16, 2017, Hong Kong. 2017.

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in Type 2 Diabetes Mellitus, 11th IDF-WPR Congress 2016 & 8th AASD Scientific Meeting, Taiwan. 2016.

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in type 2 diabetes mellitus. , 11th International Diabetes Federation Western Pacific Region Congress, Taipei, Oct 2016.. 2016.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Leung Y.H., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese., Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Leung Y.H., Han Y., SING C.W., Cheung B.M.Y., Wong I.C.K., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese, Thrombosis and Haemostasis. 2016, 117: 158-163.

Li W.H.C., Wang M.P., Lam T.H., Cheung Y.T.D., Cheung T.Y., Suen Y.N., Ho K.Y., Tan K.C.B. and Chan S.S.C., Brief intervention to promote smoking cessation and improve glycemic control in smokers with type 2 diabetes: a randomized controlled trial., Sci Rep. 2017, 7: 45902.

Tan K.C.B., "Insight from real world experience on SGLT2 inhibitors”. , The 4th China Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension, May 2017, Shanghai.. 2017.

Tan K.C.B., Shiu S.W.M. and Wong Y., Association between Serum Galectin-3 and Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 77th Scientific Sessions, San Diego, June 2017.. 2017.

Tan K.C.B., Shiu S.W.M. and Wong Y., Carbamylation of HDL in type 2 diabetes mellitus. , 52nd European Association for the Study of Diabetes Annual Meeting, Sept 2016, Munich, Germany.. 2016.

Tan K.C.B., Lifestyle intervention in familial hypercholesterolemia., Asia Pacific Federation Meeting of the International Atherosclerosis Society, May 2017, Kuala Lumpur, Malaysia.. 2017.

Tan K.C.B., Member of the Scientific Committee of the 11th International Diabetes Federation Western Pacific Region Congress, Oct 2016, Taipei. 2016.

Tan K.C.B., Member of the Scientific Committee of the17th International Congress of Endocrinology, Sept 2016, Beijing.. 2016.

Tan K.C.B., Re-examining the high-density lipoprotein hypothesis, Journal of Diabetes Investigation. 2016, 7: 445-447.

Tan K.C.B., “Changing the paradigm of type 2 diabetes treatment”. , Twelfth International Symposium on Healthy Aging, Mar 2017 , Hong Kong.. 2017.

Tan K.C.B., “EMPA-REG outcome - changing the paradigm of type 2 diabetes treatment”. , 6th Asian Preventive Cardiology Rehabilitation Conference, Nov 2016, Hong Kong.. 2016.

Tan K.C.B., “HDL functionality – coming of age”. , 17th International Congress of Endocrinology, Sept 2016, Beijing.. 2016.

Tan K.C.B., “Is an SGLT2 inhibitor right for your patient with type 2 diabetes?” , Optimizing Patient Care in Diabetes Treatment Expert Forum, Jan 2017, Shenzhen.. 2017.

Tan K.C.B., “Obesity in diabetes: what are the challenges?”. , Asia Pacific Cardiovascular and Metabolic Diseases Expert Forum, Aug 2016, Hong Kong.. 2016.

Researcher : Tan V.P.Y.

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):	Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

List of Research Outputs

Researcher : Tan VPY

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):	Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

List of Research Outputs

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

Tan V.P.Y., The low-FODMAP diet in the management of functional dyspepsia in East and Southeast Asia, Journal of Gastroenterology and Hepatology. 2017, 32: suppl 1:46-52.

Researcher : Tang CW

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	King's/HKU Fellowship Awards 2012-13
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	07/2012

Project Title:	Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015
Completion Date:	10/2016

Project Title:	Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):	Tang SCW, Feng Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):	Tang SCW, Liu Y, Yiu WH
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies
Investigator(s):	Tang SCW, Liu Y, Tse HF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Outstanding Researcher Award 2015-16
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2016

Project Title:	Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction
Investigator(s):	Tang SCW, Ma KMM, Chan JFW
Department:	Medicine
Source(s) of Funding:	Hong Kong Society of Nephrology Ltd.
Start Date:	12/2016

Project Title:	Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis
Investigator(s):	Tang SCW, Yiu WH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

Researcher : Tang SCW

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	King's/HKU Fellowship Awards 2012-13
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	07/2012

Project Title:	Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015
Completion Date:	10/2016

Project Title:	Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):	Tang SCW, Liu Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):	Tang SCW, Feng Y
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):	Tang SCW, Liu Y, Yiu WH
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies
Investigator(s):	Tang SCW, Liu Y, Tse HF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Outstanding Researcher Award 2015-16
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2016

Project Title:	Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction
Investigator(s):	Tang SCW, Ma KMM, Chan JFW
Department:	Medicine
Source(s) of Funding:	Hong Kong Society of Nephrology Ltd.
Start Date:	12/2016

Project Title:	Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis
Investigator(s):	Tang SCW, Yiu WH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Chan G.C., Lee K.M., Kwan L.P., Mok M.M., Ma M.K., Yap Y.H.D. and Tang S.C.W., A Rare Case of Famotidine-Induced Delirium in a Peritoneal Dialysis Patient, Peritoneal Dialysis International. 2017, 37: 118-120.

Chan G.C.W., Mok M.M.Y., Hung L.L., Chan J.F.W., Kwan L.P.Y., Ma M.K.M., Yap Y.H.D. and Tang S.C.W., Mycobacterium chlorophenolicum: An uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2017, 22(6): 498-499.

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Chang G.C., Yap Y.H.D., Kwan L.P., Mok M.M., Ma M.K., Chu F.S. and Tang S.C.W., Colossal renal allograft hydronephrosis causing abdominal distension, Nephrology (Carlton). 2017, 22(5): 420-421.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Jiao F., Wong C.K.H., Tang S.C.W., Fung S.C.C., Tan K.C.B., McGhee S., Gangwani R.A. and Lam C.L.K., Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong, Diabetic Medicine. 2017, 34 (9): 1276–1283.

Jiao F., Wong C.K.H., Gangwani R.A., Tan K.C.B., Tang S.C.W. and Lam C.L.K., Heath-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications., Health Qual Life Outcomes. 2017, 15(1): 125.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Tang S.C.W., "CVD in ESRD: management end challenge" , Symposium on CVD in PD, 8th Asia Pacific Chapter Meeting, International Society for Peritoneal Dialysis, Mar 23, 2017, GZ, China. 2017, 2017.

Tang S.C.W., "Diabetic nephropathy: emerging role of the renal tubule", Domestic & Foreign Elite Session, Chinese Society of Nephrology 中華醫學會腎臟病學分會2015年學術年會, Zhongqing China. 2016.

Tang S.C.W., "Diabetic nephropathy: emerging role of the renal tubule", Domestic & Foreign Elite Session, Chinese Society of Nephrology 中華醫學會腎臟病學分會2016年學術年會, Oct 15, 2016, Chongqing China. 2016, 2016.

Tang S.C.W., "FGF-23 and vascular calcification: is it set in stone?" , APSN CME Course at the Annual Scientific Meeting of the Japanese Society of Nephrology, May 25, 2017, Sendai Japan. 2017, 2017.

Tang S.C.W., "FGF-23 and vascular calcification: is it set in stone?" , International Society of Nephrology (ISN) KDIGO (Kidney Disease: Improving Global Outcomes) Clinical Practice Conference, Nanjing China. 2016.

Tang S.C.W., "Management of diabetic kidney disease: landmark clinical trials and tribulations" , Chinese Society of Nephrology 中華醫學會腎臟病學會2015年學術年會, Zhongqing China. 2016.

Tang S.C.W., "Management of diabetic kidney disease: landmark clinical trials and tribulations", Chinese Society of Nephrology 中華醫學會腎臟病學分會2016年學術年會, Oct 14, 2016, Chongqing, China. 2016, 2016.

Tang S.C.W., "Managing Cardiovascular Risks in Patients with Renal Disease", Cardiovascular and Metabolic Disease Expert Forum 2016 (AstraZeneca) . 2016.

Tang S.C.W., "New insights into the pathogenesis of DKD", Chinese Society of Physiology Annual Meeting, Jun 17, 2017, Nanjing China. 2017, 2017.

Tang S.C.W., "The Challenges of Gout Management in CKD Patients", Joint Symposium by the Hong Kong Society of Rheumatology and the Hong Kong Society of Nephrology. 2016.

Tang S.C.W., "Toll-like receptor in diabetic nephropathy" , 15th Asian Pacific Congress of Nephrology, Perth Australia. 2016.

Tang S.C.W., "Why have recent clinical trials in diabetic nephropathy failed: time for a novel and global approach?", Asia Renal Association Conference, Jun 15, 2017, Yinchuan, China. 2017, 2017.

Tang S.C.W., AFCKDI, Mar 29, 2017, Manila Philippines. 2017, 2017.

Tang S.C.W., Discussant, KDIGO Controversies Conference on Heart Failure in CKD, May 26-28, 2017, Athens Greece. 2017, 2017.

Tang S.C.W., ESRD: epidemiology and treatment in developing countries in Southeast Asia. , Clin Nephrol. 2017, 2017.

Tang S.C.W., Immunosuppressive treatment for IgA nephropathy: an update of recent clinical trials", The Silk Road Health Forum 2016 - Central Asian Symposium on Nephrology, Urumqi Xinjiang China. 2016.

Tang S.C.W., Immunosuppressive treatment of IgA Nephropathy: Yes or No?, Hong Kong College of Physicians Annual Scientific meeting. 2016.

Tang S.C.W., Nephrology in Mainland China - an update on recent progress (an online Newsletter), Nephrol Dial Transplant . 2016, 2016.

Tang S.C.W., “Pattern recognition receptor in the pathogenesis of diabetic kidney disease", Peking University Pathology Conference, Jun 22, 2017, Beijing, China . 2017, 2017.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Tang SOC

List of Research Outputs

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D., Chan K.W., Lee C.K., Tang S.O.C. and Chan D.T.M., Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations, Clinical Science. 2017, 131: 653-671.

Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y.M., Chan C.W.G., Kwan P.Y.L. and Chan D.T.M., RELAPSE OF LUPUS NEPHRITIS – RISK FACTORS AND IMPACT OF MYCOPHENOLATE TREATMENT, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Researcher : Tang SYC

List of Research Outputs

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Researcher : Tong KL

List of Research Outputs

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Researcher : Tong SM

List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Michael M.T.C., Ying H., Tong S.M. and Wong I.C.K., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Tsang HLH

List of Research Outputs

Chan C.W.S., Chung H.Y., Lau W.C.S. and Tsang H.L.H., Spontaneous pneumomediastinum in a dermatomyositis patient with anti-melanoma differentiation-associated gene-5 antibody and interstitial lung disease despite an initial response to immunosuppressant, International Journal of Rheumatic Diseases. 2017.

Chung H.Y., Lau W.H.V., Lau W.C.S. and Tsang H.L.H., Comparing Diffusion Weighted Imaging (dwi) With Clinical And Blood Parameters, And With Short Tau Inversion Recovery (stir) Sequence In Detecting Spinal And Sacroiliac (si) Joint Inflammation In Axial Spondyloarthritis (axspa), Clinical Experimental Rheumatology. 2017.

Chung H.Y., XU X., Lau W.H.V., Ho G., Lee K.L., Li P.H., Tsang H.L.H., Kwok S.K., Lau W.C.S. and Wong C.S., Comparing diffusion weighted imaging with clinical and blood parameters, and with short tau inversion recovery sequence in detecting spinal and sacroiliac joint inflammation in axial spondyloarthritis., Clin Exp Rheumatol. 2017, 35(2): 262-269.

Researcher : Tsang KWT

List of Research Outputs

Ho J.C.M., Hui K.M.C., Lam C.L.D., Tsang K.W.T., Lam W.K. and Ip M.S.M., Respiratory medicine: Long Cases, Problem Based Medical Case Management. Second Edition. Hong Kong, Hong Kong University Press, 2016, 195-218.

Researcher : Tsang WL

List of Research Outputs

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

Researcher : Tse CTA

List of Research Outputs

Cheung R.T.F., Xiong L., Chang S.K.R., Tse C.T.A., Pang S.Y.Y., Mok V., Leung T., Tsoi T.H., Li R., Mok M., Chang C.M., Lau K.K., Sheung B., Li T., Yeung J., Leung P.C., Chook P. and Wong K.S., Herbs and Rehabilitation after Stroke Study: A Multi-center, Double-blinded, Randomized Trial in Hong Kong, Journal of Stroke. 2016, 18: 361-363.

Researcher : Tse EWC

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Provision of obinutuzumab (anti-CD20 monoclonal antibody) to elderly and/or unfit patients with chronic lymphocytic leukaemia
Investigator(s):	Tse EWC, Kwong YL, Chan SYT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2017

List of Research Outputs

Chan S.Y.T., Tse E.W.C. and Kwong Y.L., Chidamide in the treatment of peripheral T-cell lymphoma, OncoTargets and Therapy. 2017, Volume 10: 347-352.

Chan S.Y.T., Lee E.Y.P., Khong P.L., Tse E.W.C. and Kwong Y.L., Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma, Hematology. 2017, 1-7.

Cheng C.W., Leong K.W. and Tse E.W.C., Understanding the role of PIN1 in hepatocellular carcinoma, World Journal of Gastroenterology. 2016.

Kukalev A., NG Y.M., JU L., Saidi A., Lane S., Mondragon A., Dormann D., Walker S.E., Grey W., Ho W.L., Stephens D.N., Carr A.N., Kamsa K., Tse E.W.C. and YU V.P., Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates, Cerebral Cortex. 2017, 27: 11-23.

Kwok G., Yau T.C.C., Chiu W.Y.J., Tse E.W.C. and Kwong Y.L., Pembrolizumab (Keytruda), Human Vaccines & Immunotherapeutics. 2016, 12: 2777-2789.

Kwong Y.L., Chan S.Y.T., Tan D., Kim S.J., Poon L.M., Mow B., Khong P.L., Loong F., Au Yeung K.H.R., Iqbal J., Phipps C. and Tse E.W.C., PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase, Blood. 2017, 129: 2437-2442.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Liew N.C., Alemany G.V., Angchaisuksiri P., Bang S.M., Choi G., DE Silva D.A., Hong J.M., Lee L., Rajamoney G.N., Suviraj J., Tan T.C., Tse E.W.C., Teo L.T., Visperas J., Wong R.S. and Lee L.H., Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism., INTERNATIONAL ANGIOLOGY. 2017, 36(1): 1-20.

Moffittt A.B., Ondrejka S.L., McKinney M., Rempel R.E., Goodlad J.R., Teh C.H., Leppa S., Mannisto S., Kovanen P.E., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Iqbal J., Yu J., Naresh K., Villa D., Gascoyne R.D., Said J., Czader M.B., Chadburn A., Richards K.L., Rajagopalan D., Davis N.S., Smith E.C., Palus B.C., Tzeng T.J., Healy J.A., Lugar P.L., Datta J., Love C., Levy S., Dunson D.B., Zhuang Y., Hsi E.D. and Dave S.S., Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2, The Journal of Experimental Medicine. 2017, 214: 1371-1386.

PIAO W., Chau H.W.D., Yue L.M., Kwong Y.L. and Tse E.W.C., Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma, Leukemia. 2017, 31: 522-526.

Tse E.W.C. and Kwong Y.L., Diagnosis and management of extranodal NK/T cell lymphoma nasal type, Expert Review of Hematology. 2016, 9: 861-871.

Researcher : Tse HF

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):	Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan HWF, Lam L, Lee KLF, Chan WS, Lam YM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):	Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2012

Project Title:	Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention
Investigator(s):	Tse HF, Schooling CM, Cowling BJ, Sham PC, Lam TH, Chan YH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2012
Completion Date:	05/2017

Project Title:	Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells
Investigator(s):	Tse HF, Ho JCY
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013

Project Title:	Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management
Investigator(s):	Tse HF, Siu DCW, Lai KWH
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	12/2014

Project Title:	Lower Thoracic Spinal Cord Stimulation for Treatment of Heart Failure with Preserved Ejection Fraction: Insight from a Porcine Model of Hypertensive Cardiomyopathy
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Discovery of New Approaches for Treating Hyperlipidemia Using an Induced Pluripotent Stem Cell (iPSC)-Based Platform
Investigator(s):	Tse HF, Esteban MA, Siu DCW, Lian Q
Department:	Medicine
Source(s) of Funding:	CAS - Croucher Funding Scheme for Joint Laboratories
Start Date:	10/2016

Project Title:	Sudden Unexpected Death (SUD) in Hong Kong
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Sun Chieh Yeh Heart Foundation - General Award
Start Date:	06/2017

List of Research Outputs

Agrawal D.E.V.A.N.S.H. .R., Tanabe Y.U.J.I., Weng D.E.S.E.N., Ma A.N.D.R.E.W., Hsu S.T.E.P.H.A.N.I.E., Liao S., ZHEN Z., Zhu Z., Sun C.H.U.A.N.B.O.W.E.N., Dong Z.H.E.N.Y.A., Yang F.E.N.G.Y.U.A.N., Tse H.F., Poon A.D.A. and Ho J.O.H.N. .S., Conformal phased surfaces for wireless powering of bioelectronic microdevices, Nature Biomedical Engineering. 2017, 1: 0043.

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

CHENG Y., Li X.C., Tse H.F., Han Y. and Rong J., Gallic acid-L-leucine (GAL) conjugate protects mice against endotoxic shock via suppressing the production of pro-inflammatory lipid mediators and nitric oxide (NO) in macrophages, 15th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Academia Sinica, Taipei, August 22 - 25, 2016.

CHENG Y., LUO D., Xia Z., Tse H.F., Li X.C. and Rong J., In Vivo Cardioprotective Effects and Pharmacokinetic Profile of N-Propyl Caffeamide Against Ischemia Reperfusion Injury, Archivum Immunologiae et Therapiae Experimentalis. 2016.

Cao G., Chen C., CHEN Y., ZHEN Z., Zou Y., Liu J., Wu M., Wang R., Liu M., Zhao C., Lu S., Ng M.Y., Tse H.F. and Yiu K.H., Prevalence, clinical characteristics and echocardiography parameters of non-resistant, resistant and refractory hypertension in Chinese., Postgrad Med.. 2017, 129(2): 187-192.

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Cheung B.M.Y., Cheng C.H., Lau C.P., Wong C.K.Y., Ma R.C.W., Chu D.W.S., Ho D.H.K., Lee K.L.F., Tse H.F., Wong A.S.P., Yan B.P.Y. and Yan W.T., 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population, Hong Kong Medical Journal. 2017, 191-201.

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Wang Y., Lam K.S.L. and Tse H.F., Clinical study of plasma lipocalin-2 and endothelial function., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Cheung B.M.Y., wang Y., Lam K.S.L. and Tse H.F., Is endothelial function related to plasma level of lipocalin-2 in man?, Presented at the 20th Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, 2016.. 2016.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Hai S.H.J.J. and Tse H.F., Freezing for the future: Next generation of cryoballoon for the treatment of atrial fibrillation., Heart Rhythm. 2016.

Hai S.H.J.J., Tam C.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Incidence and Predictors of Sudden Arrhythmic Death or Ventricular Tachyarrhythmias after Acute Coronary Syndrome: An Asian Perspective, Heart Rhythm. 2016.

Hai S.H.J.J., Chan P.H.M., Chan Y.H., Fong H.Y., Huang D., Li W.H., Yin L.X., Lau C.P., Tse H.F. and Siu D.C.W., Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry, PLOS ONE. 2016, 11: e0169095.

Hai S.H.J.J., Wong C.K., Chan P.H.M., Tse H.F., Yung T.C. and Siu D.C.W., Quinidine for Brugada syndrome: Panacea or poison?, HeartRhythm Case Rep.. 2016, 2(6): 486-490.

Hsu J.C., Akao M., Abe M., Anderson K.L., Avezum A., Glusenkamp N., Kohsaka S., Lane D.A., Lip G.Y., Ma C.S., Masoudi F.A., Potpara T.S., Siong T.W., Turakhia M.P., Tse H.F., Rumsfeld J.S. and Maddox T.M., International Collaborative Partnership for the Study of Atrial Fibrillation (INTERAF): Rationale, Design, and Initial Descriptives., J Am Heart Assoc. 2016 Nov. 2016, 5(11): 1373-1389.

Jiang D., Gao F., Zhang Y., Wong D.S., Li Q., Tse H.F., Xu G., Yu Z. and Lian Q., Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage., Cell Death Dis. 2016. 2016, 7(11): e2467.

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee S.W.L., Lam C.C.S., Tam C.C., Chan K.W.K., Shea C.P., Kong S.L., Wong A.Y., Yung A., Zhang L.W., Tse H.F., Wu K.K., Chan R., Haude M., Mehran R., Mintz G.S. and Maehara A., Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study, Circ Cardiovasc Interv.. 2016, 9(7).

Lee Y.K., Jiang Y., RAN X., Lau V.Y.M., Ng K.M., Lai K.W.H., Siu D.C.W. and Tse H.F., Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy, Stem Cell Research & Therapy. 2016.

Li L., Zhang Q., Yang H., Zou Q., Lai C., Jiang F., Zhao P., Luo Z., Yang J., Chen Q., Wang Y., Newsome P.N., Frampton J., Maxwell P.H., Li W., Chen S., Wang D., Siu T.S., Tam S., Tse H.F., Qin B., Bao X., Esteban M.A. and Lai L., Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1., J Biol Chem. 2017, 292(11): 4755-4763.

Li W., Huang D., Chiang C.E., Lau C.P., Tse H.F., Chan E.W., Wong I.C.K., Lip G., Chan P.H.M. and Siu D.C.W., Efficacy and Safety of Dabigatran, Rivaroxaban and Warfarin for Stroke Prevention in patients with Atrial Fibrillation: The Hong Kong Atrial Fibrillation Project, Clin Cardiol. 2017, 40(4): 222-229.

Li W.C., Tse H.F. and Fok L., Plastic waste in the marine environment: A review of sources, occurrence and effects., Sci Total Environ. 2016. 2016, 566-567: 333-349.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

Poon M.W., Jiang D., Qin P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Wong I.Y., Yu Z., Tse H.F., Wong D.S. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn., Sci Rep. 2017. 2017, 7: 41224.

Poon M.W., Jiang D., Qing P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Li Q., Wong Y.H.I., Yu Z., Tse H.F., Wong D.S.H. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn, Scientific Reports. 2017, 7: 41224.

Rajadurai J., Tse H.F., Wang C.H., Yang N.I., Zhou J. and Sim D., Understanding the Epidemiology of Heart Failure to Improve Management Practices: An Asia-Pacific Perspective., J Card Fail 2017. 2017, 23(4): 327-339.

Tam C.C., Chan K.W.K., Lam C.C.S., Yung A.R.T.H.U.R., Lam Y.M., Chan W.S., Siu D.C.W. and Tse H.F., One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent., J Int Med Res. 2017, Jan 1.

Tse H.F., Human Pluripotent Stem Cells Derived Mesenchymal Stem Cells as Novel Therapy for Treatment of Cardiovascular Diseases, Hong Kong Heart Foundation Lecture 2017. 2017.

Tse H.F., Interviewee, Cable TV News《Health and Fitness》, 2017.

Tse H.F., Invited Speaker, The 8th Annual Symposium on Translational Circulatory and Stem Cell Research, Kaohsiung,Taiwan Keynote Speech, Human pluripotent stem cells derived mesenchymal stem cells as novel therapy for treatment of cardiovascular diseases, 2016.

Tse H.F., Invited Speaker, 10th Heart Rhythm forum of Jiangsu Province, “ Advances in CIED”, 2017.

Tse H.F., Invited Speaker, APHRS 2016, Seoul, Korea, “Subcutaneous ICD in Asia” “High Density Mapping of Complex Atrial Arrhythmias” “Human Stem Cell Model for Human Inherited Cardiomyopathy”, 2016.

Tse H.F., Invited Speaker, Asia Atrial Fibrillation Scientific Forum, Kanazawa, Japan, “Improving disease awareness and diagnosis of AF”, 2017.

Tse H.F., Invited Speaker, China Innovations in Cardiology 2016 (CIC2016), Nanjing, China Novel Technology for CIED, 2016.

Tse H.F., Invited Speaker, China International Pacing Summit (CIPS) 2017, Haikou, China, SICD Implantation case video review session, 2017.

Tse H.F., Invited Speaker, European Society of Cardiology Congress 2016, Rome, Italy Regional heterogeneity n norepinephrine spillover in heart failure with preserved ejection fraction: insight from a porcine model of severe hypertension, 2016.

Tse H.F., Invited Speaker, Heart Rhythm Chicago, United States,“Anticoagulation Treatment in Patients With Non-Valvular Atrial Fibrillation: Real-World Clinical Practice in Hong Kong”, “Current State of the ECG Patch Monitoring Technologies for Assessment of Malignant Arrhythmias”, 2017.

Tse H.F., Invited Speaker, MACI Forum, Macau, “Update in the management of heart failure”, 2017.

Tse H.F., Invited Speaker, OCC Meeting, Shanghai,China “Increasing ICD Adoption in Asia: Current Status and Challenges” “AF Screening”, 2017.

Tse H.F., Invited Speaker, SPNVAF Masterclass 2017,” Apixaban: key clinical trial data and real-world experience”,”Optimizing dosing of NOACs: Looking beyond frequence”, 2017.

Tse H.F., Invited Speaker, Seminar for CHCSJ Cardiologists in Macau, “Cardio-protection of beta-blockers along CV continuum”, 2017.

Tse H.F., Invited Speaker, VAS China 2017, Nanjing, China, “Human Stem cell platform for drug screening in inherited cardiomyopathy”, 2017.

Tse H.F., Invited Speaker,Macau Lecture”The latest real world evidence of NOAC for patient with non –valvular AF”, 2017.

Tse H.F., Invited Speaker,SPNVAF Masterclass,Bangkok, Thailand,”Optimizing dosing of NOACs: Looking beyond frequency” “Apixaban: Key clinical trial data and real-world experience”, 2017.

Tse H.F., Press Conference HKU Faculty HKU Develops Chimeric Mouse Liver Model Helps Familial Hypercholesterolemia Patients Test Drug Response, 2017.

Tse H.F., RTHK Interviewee, of RTHK Radio 3 programme "Hong Kong Today, 2017.

Tse H.F., RTHKInterviewee, “The Making of Healers” (大醫之道)., 2017.

WANG Y., Liu H.N., ZHEN Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Decreased CPC/EPC counts in type 2 diabetes patients with periodontitis, Journal of Dental Research. 2017, 96 (Spec Iss B): 153.

WANG Y., Liu H.N., Zhen Z., Yiu K.H., Pelekos G., Tse H.F. and Jin L., Periodontal treatment affects gene expression of EPCs in DM patients, Journal of Dental Research. 2017, 96 (Spec Iss A): 2195.

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : Tse HM

List of Research Outputs

Liu H., Ho W.L., Tse H.M., Pang S.Y.Y., Ramsden D.B. and Ho S.L., Leucine-rich Repeat Kinase 2 (lrrk2) Knockin Mouse Model For Pathophysiological Studies Of Parkinson's Disease (pd), Health Research Symposium 2017 (Food and Health Bureau, Hong Kong S.A.R.). 2017.

Researcher : Tse WW

List of Research Outputs

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : Tso AWK

Project Title:	A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):	Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	12/2008

Project Title:	Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):	Tso AWK, Lam KSL, Chan DTM, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2009

List of Research Outputs

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

Researcher : Tsoi SY

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Researcher : Tsui MSH

List of Research Outputs

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Chan E.Y.T., Tsui M.S.H. and Lee S.W.L., Beta-2 microglobulin level in serum is elevated in patients presenting with acute coronary syndrome., Presented at the Great Wall International Congress of Cardiology, Beijing 2016.. 2016.

Cheung B.M.Y., tam F., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 13th Congress of the European Association for Clinical Pharmacology and Therapeutics, Prague, 2017.. 2017.

Cheung B.M.Y., Tam F.C.C., Cheung C.L., Lee S.W.L., Tsui M.S.H. and Chan E.Y.T., Serum beta-2 microglobulin level is elevated in patients with acute coronary syndrome., Presented at the 5th Seoul International Congress of Endocrinology and Metabolism 2017.. 2017.

Researcher : WANG L

List of Research Outputs

WANG L., Wong K.Y., LI Z. and Chim J.C.S., Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia, Oncotarget. 2016.

Researcher : WANG Y

List of Research Outputs

WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-intensity intermittent hypoxia promotes subcutaneous adipogenic differentiation, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 44.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : WONG WLD

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : WU H

List of Research Outputs

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : WU X

List of Research Outputs

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Shu L., WU X., PAN Y., CHEONG L.Y., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) modulates adaptive thermogenesis by enhancing intracellular activation of thyroid hormones in brown adipocytes, 2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of KSSO . 2016.

WU X., Shu L., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of liver fibrosis, FASEB Science Research Conference. 2017.

Researcher : Wang AYM

Project Title:	An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):	Wang AYM, Kwan CW, Lai KN
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	07/2008

Project Title:	Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):	Wang AYM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Researcher : Wang J

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Researcher : Wang J.

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Researcher : Wang KLJ

List of Research Outputs

Leung T.H.S., Ngai C.Y.V., Chan H.Y.F., Chui C.M.W., Ip M.S.M., Wang K.L.J., Ho K.Y.C., Mo S.L.S. and Poon K.H.H., Pilot program for improving drug adherence and minimizing drug wastage in patients with asthma or chronic obstructive pulmonary disease (COPD), Hospital Authority Convention, May 2017. Abstract.

Researcher : Wat NMS

List of Research Outputs

Cheung B.M.Y., Fong C.H.Y., Chen C., Cho A.W.K., Wang Y., Law L.S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., LBPS 02-06 PLASMA LEVEL OF FIBROBLAST GROWTH FACTOR 21 IS INDEPENDENTLY RELATED TO BLOOD PRESSURE, Journal of Hypertension. 2016, 34: e507.

Researcher : Wei R

List of Research Outputs

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Wong B.C.Y.

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Researcher : Wong BCY

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Researcher : Wong CF

List of Research Outputs

Chung A.Y., Anand S., Wong I.C.K., Tan K.C.B., Wong C.F., Chui C.M.W. and Chan E.W., Improving medication safety and diabetes management in Hong Kong: a multidisciplinary approach, Hong Kong Medical Journal. 2017, 23(2): 158-67.

Researcher : Wong CM

Project Title:	Coupling of nuclear RNA surveillance with splicing
Investigator(s):	Wong CM, Chen C
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Researcher : Wong DKH

Project Title:	Mutational analysis of the hepatitis B core protein DNA-binding domain and its role in HBV transcription regulation
Investigator(s):	Wong DKH, Huang FY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	11/2016

Project Title:	Hepatitis B X protein primary structure and epigenetic regulation of HBV replication
Investigator(s):	Wong DKH, Huang FY, Seto WKW, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014
Completion Date:	06/2017

List of Research Outputs

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., High level of Wisteria floribunda agglutinin-positive human Mac-2 binding protein is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral treatment. Oral Presentation, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11 (Suppl 1): S72.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy, J Viral Hepat. 2017, 24(8): 654-61.

Cheung K.S., Seto W.K.W., Wong D.K.H., Mak L.Y., Lai C.L. and Yuen R.M.F., Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment, Oncotarget. 2017, 8(29): 47507-17.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Li J., Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of IL-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection. [Poster presentation, Hepatology 2016; 64(S1):877A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Li J., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver Int. 2017, 37(9): 1287-94.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Wong D.K.H., Assessment of liver fibrosis stages in chronic hepatitis B patients by serum M2BPGi levels, New Findings of M2BPGi in HBV Patients. 2017.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Wong KY

List of Research Outputs

BAI Y., Wong K.Y., Fung T.K. and Chim J.C.S., High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes, Journal of Hematology & Oncology. 2016.

WANG L., Wong K.Y., LI Z. and Chim J.C.S., Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia, Oncotarget. 2016.

Researcher : Wong LC

List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Researcher : Wong LY

List of Research Outputs

Ng K.M., Mok P.Y., Butler A.W., Ho J.C., Choi S.W., Lee Y.K., Lai K.W.H., Au K.W., Lau V.Y.M., Wong L.Y., Esteban M.A., Siu D.C.W., Sham P.C., Colman A. and Tse H.F., Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor., Circulation.. 2016, 134(18): 1373-1389.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : Wong LYF

Project Title:	Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Wong SY

List of Research Outputs

Leung W.K., But Y.K.D., Wong S.Y., Liu S.H.K. and Hung F.N.I., Prevention of Post-sphincterotomy Bleeding by Proton Pump Inhibitor: A Prospective Randomized Trial, 25th United European Gastroenterology Week, 15-19 Oct 2016, Vienna, Austria. 2016.

Researcher : Wong TW

List of Research Outputs

Lee C.H.A., Chan P.H.M., Cheung C.L., Siu D.C.W., Leung Y.H., Wong T.W., Pang H.K. and Tan K.C.B., Diagnostic performance of different clinical criteria for familial hypercholesterolemia in Hong Kong Chinese patients. , 33rd Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong Nov 2016.. 2016.

Researcher : Wong WSR

List of Research Outputs

YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553.

Researcher : Wong Y

List of Research Outputs

Lee C.H.P., Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-beta HDL in type 2 diabetes mellitus. , 11th International Diabetes Federation Western Pacific Region Congress, Taipei, Oct 2016.. 2016.

Tan K.C.B., Shiu S.W.M. and Wong Y., Association between Serum Galectin-3 and Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 77th Scientific Sessions, San Diego, June 2017.. 2017.

Tan K.C.B., Shiu S.W.M. and Wong Y., Carbamylation of HDL in type 2 diabetes mellitus. , 52nd European Association for the Study of Diabetes Annual Meeting, Sept 2016, Munich, Germany.. 2016.

Researcher : Wong YK

List of Research Outputs

Lau G.K.K., Li L., Lovelock C.E., Simoni M., Schulz U., Zamboni G., Wong Y.K., Teo K.C., Rothwell P.M. and Mak H.K.F., Prognostic implications of neuroimaging markers of small vessel disease in patients with transient ischemic attack and ischemic stroke, Thomas Willis Day, University of Oxford. 2017.

Researcher : Woo YC

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lang H.H.B., Woo Y.C. and Wong C.K.H., High-Intensity Focused Ultrasound for Treatment of Symptomatic Benign Thyroid Nodules: A Prospective Study, Radiology. 2017, 284 (3): 897–906.

Lang H.H.B., Woo Y.C. and Chiu W.H.K., High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function, International Journal of Hyperthermia. 2017, Epub ahead of print.

Lang H.H.B., Woo Y.C. and Chiu W.H.K., Single-session high-intensity focused ultrasound treatment in large-sized benign thyroid nodules, Thyroid. 2017, Epub ahead of print.

Lang H.H.B., Woo Y.C. and Chiu W.H.K., Vocal cord paresis following single-session high intensity focused ablation (HIFU) treatment of benign thyroid nodules - incidence and risk factors, International Journal of Hyperthermia. 2017, Epub ahead of print.

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Lee C.H.P., Chow W.S., Woo Y.C., Fong H.Y., Chan K.H. and Lam K.S.L., Glycemic control predicts the development of dementia in type 2 diabetes, The International Diabetes Federation World Diabetes Congress, Vancouver, Canada. 2016.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Leung O.Y., Janus E.D., Cheung B.M.Y. and Lam K.S.L., Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese, PLOS ONE. 2016, 11: e0163424.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

Researcher : Wu CH

List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Researcher : Wu H

List of Research Outputs

Researcher : XU J

List of Research Outputs

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

Researcher : XU L

List of Research Outputs

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Researcher : XU P

List of Research Outputs

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and cardiovascular events in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

XU P., Hui K.M.C., Fong D.Y.T. and Ip M.S.M., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 46.

Researcher : XU S

List of Research Outputs

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. WCLC 2016, Vienna (Abstract ID 4859)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna Austria. 2016.

Ho J.C.M., U K.P., XU S., Cheng P.N. and Lam S.K., Suppression of tumour growth by pegylated arginase in malignant pleural mesothelioma. WCLC 2016, Vienna (Abstract ID 4854)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Lam S.K., Li Y.V., XU S., LEUNG L.L., U K.P., ZHENG Y.F., CHENG P.N. and Ho J.C.M., Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts, Respiratory Research. 2017, 18(1): 80.

Lam S.K., XU S. and Ho J.C.M., Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, 22nd Medical Research Conference. 2017, 23: 26.

XU S., Lam S.K., Cheng P.N. and Ho J.C.M., In vitro effects of pegylated arginase in small cell lung cancer. WCLC 2016, Vienna (Abstract ID 4163)., 17th World Conference on Lung Cancer, 4-7 Dec 2016, Vienna, Austria. 2016.

Researcher : Xia HHX

Project Title:	Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2003

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2004

Project Title:	Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2005

Researcher : Xiong J

Project Title:	2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):	Xiong J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2008

Researcher : Xu A

Project Title:	Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2007

Project Title:	Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2011

Project Title:	71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2011

Project Title:	Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Adipocyte fatty acid binding protein as a mediator of obesity-related medical complications
Investigator(s):	Xu A, Hoo RLC
Department:	Medicine
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2014
Completion Date:	12/2016

Project Title:	Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain
Investigator(s):	Xu A, Cheng KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes
Investigator(s):	Xu A, Lam KSL, Chan YCC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	04/2015

Project Title:	Neutrophil-derived proteinase 3 as a new player in the pathogenesis of obesity-induced non-alcoholic steatohepatitis
Investigator(s):	Xu A, Ye D
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	2015 51st EASD Annual Meeting ; Adiponectin is required for adaptive thermogenesis by enhancing the browning of white adipose tissues in mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015

Project Title:	Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2015

Project Title:	Frontiers in Immunometabolism
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	11/2015

Project Title:	Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Brown adipose tissue as a new weapon against obesity-related vascular disorders
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis
Investigator(s):	Xu A, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism
Investigator(s):	Xu A, Woo WHC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	FGF21 as a potential mediator for the anti-depressant effects of physical exercise
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Fibroblast growth factor-21 as an Autocrine Regulator of Browning and Adaptive Thermogenesis in Subcutaneous Adipose Tissue
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Vascular Dysfunction in Obestiy and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2017

Project Title:	Adiponectin antagonizes dietary obesity-induced metabolic dysfunction via modulation of gut microbiota
Investigator(s):	Xu A, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Institute of Metabolic Medicine (AoE)
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	Development of an Innovative Immunoturbidimetric Assay (ITA) of Lipocalin-2 (LCN2) for Prognosis and Diagnosis of Diabetes and its Cardiovascular Complications
Investigator(s):	Xu A, Zhong L, Zhou P
Department:	Medicine
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	A multi-disciplinary study on the beneficial effects of PPARD in physical exercise against diabetic vascular complications: cellular crosstalk and energy metabolism
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice, Acta Pharmacologica Sinica. 2017, 38: 498-512.

CHEN J., LI J., Xu A. and Woo W.H.C., Metabolic Function of TIR-Domain-containing adapter-inducing interferon-b (TRIF) in hepatocytes, In: Federation of American Societies for Experimental Biology, FASEB Science Research Conference: Immunological Aspects of Obesity. 2016.

CHEN J., Li J., Xu A. and Woo W.H.C., Metabolic function of TIR-domain-containing adapter-inducing interferon-b (TRIF) in hepatocytes, FASEB Science Research Conferences, July 31- August 5, 2016, Big Sky, Montana. 2016.

Chan J.S.M., Li A., Ng S.M., Ho R.T.H., Xu A., Yao T.J., Wang X.M.A., So K.F. and Chan C.L.W., Adiponectin Potentially Contributes to the Antidepressive Effects of Baduanjin Qigong Exercise in Women With Chronic Fatigue Syndrome-Like Illness, Cell Transplantation. 2017, 26: 493-501.

Cheang W., Wong W., Zhao L., Xu J., Wang L., Lau C., Chen Z., Ma R...C..., Xu A., Wang N., Tian X. and Huang Y., PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice, Diabetes. 2017, 66: 519-528.

Chen D., Brown R., Liess C., Pokjak A., Xu A., Zhang J., renell M., Jenkins A., Chisholm D., Samocha-Bonet D., Macefield V. and Greenfield J., Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men, Frontiers in Physiology. 2017, 8.

Cheung B.M.Y., Fong C.H.Y., Chen C., Cho A.W.K., Wang Y., Law L.S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., LBPS 02-06 PLASMA LEVEL OF FIBROBLAST GROWTH FACTOR 21 IS INDEPENDENTLY RELATED TO BLOOD PRESSURE, Journal of Hypertension. 2016, 34: e507.

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Tang S.M., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Cherny S.S., Jiang C.Q., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals, Diabetologia. 2017, 60: 107-115.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

DETREMMERIE C.M.S., CHEN Z., LI Z., ALKHARFY K.M., Leung S.W.S., Xu A., GAO Y. and Vanhoutte P.M.G.R., Endothelium-Dependent Contractions of Isolated Arteries to Thymoquinone Require Biased Activity of Soluble Guanylyl Cyclase with Subsequent Cyclic IMP Production, Journal of Pharmacology and Experimental Therapeutics. 2016, 358: 558-568.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y.S. and Vanhoutte P.M.G.R., Mechanisms of Vasodilatation 12th International Symposium. November 6-9, 2016, Rochester, Minn., USA: Abstracts, Journal of Vascular Research. 2016, 53: 1-70.

GENG L., LIAO B., JIN L., HUANG Z., Woo W.H.C., Lam K.S.L. and Xu A., Chronic exercise alleviated dietary obesity-associated metabolic dysfunction by enhancing FGF-21 sensitivity in adipose tissues., The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Gong Q., Hu Z., Zhang F., Cui A., Chen X., Jiang H., Gao J., Chen X., Han Y., Liang Q., Ye D., Shi L., Chin Y.E., Wang Y., Xiao H., Guo F., Liu Y., Zang M., Xu A. and Li Y., Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice, Hepatology. 2016, 64: 425-438.

Guo R., Lin B., PAN J., Liong E.C., Xu A., Youdim M., Fung M.L., So K.F. and Tipoe G.L., Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophage, Scientific Reports. 2016, 6: 32447.

Hoo R.L.C., SHU L., Cheng K.Y., WU X., LIAO B., Wu D., Zhou Z. and Xu A., Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy., Scientific Reports. 2017.

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

Huang Z., Xu A. and Cheung B.M.Y., The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension, Current Hypertension Reports. 2017, 19.

Hui X., Gu P., Zhang J., Wang Y. and Xu A., 2016 Research Output Award, The University of Hong Kong. 2016.

Hui X., Gao Y., Wang Y. and Xu A., Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, EMBO reports. 2017, 18: 645-657.

Jang H., Lee G.Y., Selby C.P., Lee G., Jeon Y.G., Lee J.H., Cheng K.Y., Titchenell P., Birnbaum M.J., Xu A., Sancar A. and Kim J.B., SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. , Nature Communications. 2016, 7.

Jo E., Li S., Liang Q., Zhang X., Wang H., Herbert T., Jenkins T., Xu A., Ye J. and Guiliou H., Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21, PLOS ONE. 2017, 12: e0173676.

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Mao L., Nie B., Nie T., Hui X., Gao X., Lin X., Liu X., Xu Y., Tang X., Yuan R., Li K., Li P., Ding K., Wang Y., Xu A., Fei J., Han W., Liu P., Madsen L., Kristansen K., Zhou Z., Deng S. and Wu D., Visualization and Quantification of Browning Using a Ucp1 -2A-Luciferase Knock-in Mouse Model , Diabetes. 2017, 66: 407-417.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Nie B.M., Nie T., Hui X., Gu P., Mao L.F., Li K., Yuan R., Zheng J., Xu A., Wu D. and Ding S., Brown adipogenic reprogramming induced by a small molecule, Cell reports. 2017, 18: 624.

SHU L., Hoo R.L.C., WU X., PAN Y., LEE P.C., CHEONG L.Y., Bornstein S.R., Rong X., Gua J. and Xu A., A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes., Nature Communications. 2017.

Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte Fatty Acid Binding Protein (A-FABP) in obesity and its related complications: Friend or Foe?, 4th Lingnan International Symposium of Metabolic Diseases: Frontiers in Immunometabolism. 2017.

Shu L., WU X., PAN Y., CHEONG L.Y., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) modulates adaptive thermogenesis by enhancing intracellular activation of thyroid hormones in brown adipocytes, 2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of KSSO . 2016.

Sun W.Y., Yang K., Luo C., Feletou M., Villeneuve N., Vanhoutte P.M.G.R., Xu A. and Wang Y., Role of lipocalin-2 in dietary and aldosterone-induced renal damages, Experimental Biology 2017. The FASEB, 31.

WANG Y., TSE M.A., LIU Y., Zhu C.F., Liang Q. and Xu A., High Intensity Exercise: A Multi-beneficial Exercise Modality to Promote Browning of White Adipose Tissue, Reduce Fat Accumulation and Control Metabolic Disease, 10th International Conference on Strength Training, Kyoto, Japan, November 30-December 2, 2016.

WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-intensity intermittent hypoxia promotes subcutaneous adipogenic differentiation, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 44.

WU X., Shu L., CHEONG L.Y., Lam K.S.L., Xu A. and Hoo R.L.C., The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of liver fibrosis, FASEB Science Research Conference. 2017.

Wang X., Lo C.M., Chen L., Ngan E.S.W., Xu A. and Poon R.Y., CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency, Cell Death and Differentiation. 2016, 24(1): 38-48.

Woo Y.C., Lee C.H.P., Fong H.Y., Xu A., Tso A.W.K., Cheung B.M.Y. and Lam K.S.L., Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes, Clinical Endocrinology. 2017, 86: 37-43.

YANG K., Deng H., MAN W.C., SONG E., Zhang J., Luo C., Cheung B.M.Y., Yuen K.Y., Jensen P.S., Irmukhamedov A., Elie A...G...I...M., Vanhoutte P.M.G.R., Xu A., De Mey J.G.R. and Wang Y., Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment, ESC Heart Failure. 2017, 1-13.

Yang J., Wang Y., Liu C., Shi T., Liu J., Cao X., Yang F., Feng J., Chen C., Ji L. and Xu A., Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study, Diabetes Care. 2017, 40: 253-260.

Yiu J.H.C., Xu A. and Woo W.H.C., Anticipation of toll-like receptor 5 in atherosclerosis via regulation of lipoproteins, Keystone Symposium: Integrating Metabolism and Immunity, Dublin, 29May-2Jun, 2017.

ZHANG C., Yan C.H., Xu A., Chan B.P. and Chiu P.K.Y., Knocking out or Pharmaceutical Inhibition of Fatty Acid Binding Protein 4 (FABP-4) Alleviates Osteoarthritis Induced by A Very High Fat Diet in Mouse, The 2017 annual congress of Osteoarthritis Research Society International. 2017.

ZHANG C., Yan C.H., Chiu P.K.Y. and Xu A., Young Investigator Award, Osteoarthritis Research Society International. 2017.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Zhou M., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP)is a potential mediator of heart dysfunction and failure related to obesity, the 11th International Diabetes Federation Western Pacific Region Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes in Taipei, Taiwan . 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Vanhoutte P.M.G.R., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clinical Science. 2016.

Zhu C.F. and Xu A., Marine Collagen Peptides Reduce Endothelial Cell Injury In Diabetic Rats By Inhibiting Apoptosis And The expression Of Coupling Factor 6 And Microparticles, Molecular Medicine Reports. July 21, 2017, 2017, 16: 3947-3957.

Researcher : YAN S

List of Research Outputs

TAM C.Y., Li W.M.M., Gao Y.P., PANG Y.T., Yan S., Ge W., Lau W.C.S. and Chan V.S.F., Human CLEC16A regulates autophagy through modulating mTOR activity, Experimental Cell Research. 2017, 352: 304-312.

YIM L.Y., YAN S., LEE C.P., Chan V.S.F. and Lau W.C.S., Dendritic cells display aberrant Toll-like receptor 7/9 responses in systemic lupus erythematosus, Asian Congress on Autoimmunity 2017 & Lupus 2017.

Researcher : YANG C

List of Research Outputs

Chiu P.W., YANG C., Har A., Mak H.K.F. and Kwan S.K.J., Magnetic resonance spectroscopy demonstrates neuronal loss and altered glutamatergic neurotransmission in Alzheimer's Disease, 22nd Medical Research Conference (HKU). 2017.

YANG C., Wong G.T.C. and Kwan S.K.J., Event related potential during prospective memory task may predict cognitive function in subjective cognitive decline, 12th International Symposium on Healthy Aging. 2017.

YANG C., LI J., Wong G.T.C. and Kwan S.K.J., Event-related potential using task-based electroencephalogram may differentiate between mild cognitive impairment and normal controls, 22nd Medical Research Conference (HKU). 2017.

YANG C., Wong G.T.C. and Kwan S.K.J., The behavioral performance and event-related potential components of the go/no-go task from healthy elders to mild cognitive impairment, 12th International Symposium on Healthy Aging. 2017.

Researcher : YANG J

List of Research Outputs

XU J., Lee Y.K., RAN X., Liao S., YANG J., Au K.W., Lai K.W.H., Esteban M.I.G.U.E.L. .A. and Tse H.F., Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration, STEM CELLS. 2016.

YANG J., WANG Y., Zhou T., Wong L.Y., Tian X.Y., Hong X., Lai K.W.H., Au K.W., Wei R., Liu Y., Cheng L.H., Liang G., Huang Z., Fan W., Zhao P., Wang X., Ibanez D.P., Luo Z., Li Y., Zhong X., Chen S., Wang D., Li L., Lai L., Qin B., Bao X., Hutchins A.P., Siu D.C.W., Huang Y., Esteban M.A. and Tse H.F., Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells., Stem Cell Reports.. 2017, 8(3): 605-618.

Researcher : YIM LY

List of Research Outputs

Li W.M.M., YIM L.Y., Chan V.S.F. and Lau W.C.S., Autoimmune-associated Gene Clec16a Regulates Nlrp3 But Not Aim2 Inflammasome Pathway In Human Macrophages, Asian Congress of Autoimmunity 2017 & Lupus 2017.

YIM L.Y., Dendritic cell abnormalities and their contributions in Systemic Lupus Erythematosus pathogenesis, HKU PhD thesis. 2017.

YIM L.Y., YAN S., LEE C.P., Chan V.S.F. and Lau W.C.S., Dendritic cells display aberrant Toll-like receptor 7/9 responses in systemic lupus erythematosus, Asian Congress on Autoimmunity 2017 & Lupus 2017.

Yan S., Yim L.Y., Tam C.Y., Chan W.K., Lu L., Lau W.C.S. and Chan V.S.F., MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice, International Journal of Molecular Sciences. 2016, 17: 1282.

Researcher : Yam IYL

List of Research Outputs

Yap Y.H.D., Lee P., Yam I.Y.L., Tam H.Y., Wong S., Yung S.S.Y. and Chan D.T.M., Effect of Cyclophosphamide and Mycophelonate Mofetil on Lymphocyte Subsets in Patient with Active Lupus Nephritis, 54th Congress of European Renal Association-European Dialysis and Transplant Association , Madrid, Spain. 2017.

Researcher : Yan S

List of Research Outputs

Researcher : Yap YHD

Project Title:	A Therapeutic Drug Monitoring Program of Mycophenolic Acid in patients with Lupus Nephrities
Investigator(s):	Yap YHD
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2013

Project Title:	Relationship between Mycophenolic Acid Pharmacokinetics and Pharmacogenomics with treatment response and disease activity in lupus nephritis
Investigator(s):	Yap YHD, Ma KMM, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Lymphocyte subset profile and clinical phenotype in lupus nephritis
Investigator(s):	Yap YHD, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Brandl A., Daum P., Brenner S., Schulz S.R., Yap Y.H.D., Bosl M.R., Wittmann J.R., Schuh W. and Jack H.M., The microprocessor component, DGCR8, is essential for early B-cell development in mice, European Journal of Immunology. 2016, 46: 2710-2718.

Chan G.C., Lee K.M., Kwan L.P., Mok M.M., Ma M.K., Yap Y.H.D. and Tang S.C.W., A Rare Case of Famotidine-Induced Delirium in a Peritoneal Dialysis Patient, Peritoneal Dialysis International. 2017, 37: 118-120.

Chan G.C.W., Mok M.M.Y., Hung L.L., Chan J.F.W., Kwan L.P.Y., Ma M.K.M., Yap Y.H.D. and Tang S.C.W., Mycobacterium chlorophenolicum: An uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2017, 22(6): 498-499.

Chan K.Y., Yap Y.H.D., Li C.W., Cheng H.W. and Au H.Y., Excessive watermelon consumption causing hyperkalaemia and increased symptom burden of an end stage renal disease patient, Nephrology (Carlton). 2016, 21(8): 721.

Chang G.C., Yap Y.H.D., Kwan L.P., Mok M.M., Ma M.K., Chu F.S. and Tang S.C.W., Colossal renal allograft hydronephrosis causing abdominal distension, Nephrology (Carlton). 2017, 22(5): 420-421.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding Immunoglobulin G Level Correlates with Clinical and Renal Histological Disease Activity in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding immunoglobulin level correlates with renal histological features in lupus nephritis, ASN Kidney Week 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D., Chan K.W., Lee C.K., Tang S.O.C. and Chan D.T.M., Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations, Clinical Science. 2017, 131: 653-671.

Li P.H., Cheng V.C., Yip T., Yap Y.H.D., Lui S.L. and Lo W.K., Epidemiology and Clinical Characteristics of Acinetobacter Peritoneal Dialysis-Related Peritonitis in Hong Kong?With a Perspective on Multi-Drug and Carbapenem Resistance , Peritoneal Dialysis International. 2017, 37: 177-182.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Yap Y.H.D., Best Abstract in Basic Science & Translational (Poster)- 22nd Medical Research Conference, Department of Medicine, The University of Hong Kong, Department of Medicine, The University of Hong Kong. 2017.

Yap Y.H.D., Chan J.F.W., Yip T., Mok M.M., Kwan L., Lo W.K. and Chan D.T.M., Burkholderia Cepacia Exit-site infection in peritoneal dialysis patients - clinical characteristics and treatment outcomes, Peritoneal Dialysis International. 2016, 36(4): 390-394.

Yap Y.H.D., Lee P., Yung S.S.Y. and Chan D.T.M., Circulating lymphocyte subsets and disease relapse in lupus nephritis, ASN Kidney Week 2016 Annual Meeting, Chicago, America. 2016.

Yap Y.H.D., Diagnosis and management of exit site infection in peritoneal dialysis patients, Peritoneal Dialysis. InTech, 2016.

Yap Y.H.D., Lee P., Yam I.Y.L., Tam H.Y., Wong S., Yung S.S.Y. and Chan D.T.M., Effect of Cyclophosphamide and Mycophelonate Mofetil on Lymphocyte Subsets in Patient with Active Lupus Nephritis, 54th Congress of European Renal Association-European Dialysis and Transplant Association , Madrid, Spain. 2017.

Yap Y.H.D., Hemoperitoneum, 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis, Guangzhou, China . 2017.

Yap Y.H.D. and Chan D.T.M., LONG-TERM DATA ON SIROLIMUS TREATMENT IN LUPUS NEPHRITIS PATIENTS, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yap Y.H.D. and Chan D.T.M., PRE-EMPTIVE TREATMENT FOR ASYMPTOMATIC SEROLOGICAL REACTIVATION IN LUPUS NEPHRITIS PATIENTS – IMPACT ON CLINICAL FLARE RATE AND RENAL FUNCTION, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y.M., Chan C.W.G., Kwan P.Y.L. and Chan D.T.M., RELAPSE OF LUPUS NEPHRITIS – RISK FACTORS AND IMPACT OF MYCOPHENOLATE TREATMENT, 12th International Congress on Systemic Lupus Erythematosus & the 7th Asia Congress on Autoimmunity, Melbourne, Australia . 2017.

Yap Y.H.D., Seto W.K.W., Fung J.Y.Y., Chok K.S.H., Chan S.C., Chan G.C.W., Yuen R.M.F. and Chan T.M., Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis, Digestive and Liver Disease. 2016, 49(2): 202-206.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Yap Y.H.D. and Chan D.T.M., Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis, F1000Research. 2017, 6: 874.

Researcher : Yau TCC

Project Title:	The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):	Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:	Surgery
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2011

Project Title:	A Pilot Study to Evaluate the Prophylactic Effects of Telbivudine for Prevention of Hepatitis B Reactivation in HBsAg Positive Patients Receiving Sorafenib Treatment for Advanced Hepatocellular Carcinoma
Investigator(s):	Yau TCC, Poon RTP
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases
Investigator(s):	Yau TCC
Department:	Surgery
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients
Investigator(s):	Yau TCC, Poon RTP
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	A Phase II study of the safety and efficacy of PEG-BCT-100 combined with capecitabine/oxaliplatin in patients with advanced hepatocellular carcinoma (Part I)
Investigator(s):	Yau TCC
Department:	Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	04/2014

Project Title:	Randomized Phase II Trial of Sorafenib, Capecitabine and Oxaliplatin (SECOX) versus Single Agent Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Investigator(s):	Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	04/2015

Project Title:	A Prospective Validation of the Hong Kong Liver Cancer (HKLC) Prognostic Staging System: A Multi-Centre Study in Hong Kong
Investigator(s):	Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	A Combination of Sorafenib, Oxaliplatin and Capecitabine as Neoadjuvant Therapy for Patients with Locally Advanced Hepatocelullar Carcinoma: A Phase II Study
Investigator(s):	Yau TCC, Cheung TT
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2016

List of Research Outputs

Cheng A.L., Cornelio G., Shen L., Price T., Yang T.S., Chung I.J., Dai G.H., Lin J.K., Sharma A., Yeh K.H., Ma B., Zaatar A., Guan Z., Masood N., Srimuninnimit V., Yau T.C.C., Gibbs P., Wang X., Doval D.C., Seung-Taek O., Shim B.Y., Gorospe C., Wang H.M., Sirachainan E., Hill A., Suh K.W., Beier F., Chatterjee S. and Lim R., Efficacy, Tolerability, and Biomarker Analyses of Once-Every-2-Weeks Cetuximab Plus First-Line FOLFOX or FOLFIRI in Patients With KRAS or All RAS Wild-Type Metastatic Colorectal Cancer: The Phase 2 APEC Study, Clinical Colorectal Cancer. 2017, e73-e88.

El-Khoueiry A.B., Sangro B., Yau T.C.C., Crocenzi T.S., Kudo M., Hsu C., Kim T.Y., Choo S.P., Trojan J., Welling T.H., Meyer T., Kang Y.K., Yeo W., Chopra A., Anderson J., Dela Cruz C., Lang L., Neely J., Tang H., Dastani H.B. and Melero I., Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial, Lancet. 2017, 389: 2492-2502.

Goh G., Schmid R., Guiver K., Arpornwirat W., Chitapanarux I., Ganju V., Im S.A., Kim S.B., Dechaphunkul A., Maneechavakajorn J., Spector N., Yau T.C.C., Afrit M., Ben Ahmed S., Johnston S.R., Gibson N., Uttenreuther-Fischer M., Herrero J. and Swanton C., Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine, PLoS Medicine. 2016, e1002136.

Kwok G., Yau T.C.C., Chiu W.Y.J., Tse E.W.C. and Kwong Y.L., Pembrolizumab (Keytruda), Human Vaccines & Immunotherapeutics. 2016, 12: 2777-2789.

Leung R.C.Y., Yau T.C.C., Chan M.C., Chan S.W., Chan T.W., Tsang Y.Y., Wong T.T., Chao C., Yoshizawa C., Soong I.S., Kwan W.H., Kwok C.C., Suen J.S., Ngan R.K. and Cheung P.S., The Impact of the Oncotype DX Breast Cancer Assay on Treatment Decisions for Women With Estrogen Receptor-Positive, Node-Negative Breast Carcinoma in Hong Kong, Clinical Breast Cancer. 2016, 16: 372-378.

Ng L., Wan T.M.H., Man H.W., Chow K.M., Lyer D., Chen G., Yau T.C.C., Lo O.S.H., Foo C.C., Poon T.C.J., Leung W.K., Pang R.W.C. and Law W.L., Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer, Oncotarget. 2017, 8(16): 27393-27400.

Yau T.C.C., Lencioni R., Sukeepaisarnjaroen W., Chao Y., Yen C.J., Lausoontornsiri W., Chen P.J., Sanpajit T., Camp A., Cox D.S., Gagnon R., Liu Y., Raffensperger K.E., Kulkarni D., Kallender H., Ottesen L.H. and Bottaro D.P., A Phase 1/2, Multicentre Study of Single-Agent Foretinib as First-Line Therapy in Advanced Hepatocellular Carcinoma Patients, Clinical Cancer Research. 2017, 2405-2413.

Yau T.C.C., Lencioni R., Sukeepaisarnjaroen W., Chao Y., Yen C.J., Lausoontornsiri W., Chen P.J., Sanpajit T., Camp A., Cox D.S., Gagnon R.C., Liu Y., Raffensperger K.E., Kulkarni D.A., Kallender H., Ottesen L.H., Poon R.T.P. and Bottaro D.P., A phase I/II multicenter study of single-agent foretinib as first-line therapy in patients with advanced hepatocellular carcinoma, Clinical Cancer Research. 2016, 23(10): 2405-2413.

Yau T.C.C., Scientific Committee Chairman, 3nd International Conference on Phase 1 and Early Phase Clinical Trials (ICPOEP 2016). 2016.

Researcher : Ye D

Project Title:	Lipocalin-2 in acute and chronic liver diseases: focusing on neutrophil-mediated innate immune responses
Investigator(s):	Ye D, Wang Y, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	05/2017

Project Title:	Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota
Investigator(s):	Ye D
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

List of Research Outputs

KWOK H.M., Cheng K.Y., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice, Clinical Science. 2016, 130(22): 2087-100.

Researcher : Yeung CK

Project Title:	*HLA-B 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong**
Investigator(s):	Yeung CK, Tang SCW, Cheung BMY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2012

List of Research Outputs

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Researcher : Yeung CY

List of Research Outputs

Lee C.H.P., Huang G., Chan P.H.M., Hai S.H.J.J., Yeung C.Y., Fong H.Y., Woo Y.C., Ho K.L., Yiu M.K., Leung F.K.L., Lau T.W., Tse H.F., Lam K.S.L. and Siu D.C.W., Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma, PLOS ONE. 2017, 12: e0171495.

Luk A.O.Y., Hui E.M.T., Sin M.C., Yeung C.Y., Chow W.S., Ho A.Y.Y., Hung H.F., Kan E., Ng C.M., So W.Y., Yeung C.K., Chan K.S., Chan K.W., Chan P.F., Siu S.C., Tiu S.C., Yeung T.F., Chan J.C.N., Chan F.W.K., Chan C., Cheung N.T., Ho S.T., Lam K.S.L., Yu L.W.L., Chao D. and Lau I.T., Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database, Diabetes Care. 2017, 40: 928-935.

Researcher : Yeung SC

List of Research Outputs

LI X., Zhang Y., CUI Y., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Mesenchymal stem cells exert stem cell factor (SCF)-dependent recovery of cigarette smoke-induced apoptosis /proliferation imbalance in airway cells, J Cell Mol Med. 2017, 21: 265-277.

Researcher : Yick LW

Project Title:	Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation
Investigator(s):	Yick LW, Chan SY
Department:	Paediatrics & Adolescent Med
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

List of Research Outputs

Chan K.H., Ng C.L. and Yick L.W., Immunopathological Effects Of Aquaporin-4 IgG In Neuromyelitis Optica Spectrum Disorders, MOJ Immunology. 2017, 5(5): 00168.

Researcher : Yim LY

List of Research Outputs

YIM L.Y., Dendritic cell abnormalities and their contributions in Systemic Lupus Erythematosus pathogenesis, HKU PhD thesis. 2017.

Researcher : Yiu KH

Project Title:	Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Investigator(s):	Yiu KH, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Reversibility of liver stiffness after tricuspid annulopasty: A case-control study
Investigator(s):	Yiu KH, Tse HF, Seto WKW
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

List of Research Outputs

CHEN Y. and Yiu K.H., Growing importance of valvular heart disease in the elderly., J Thorac Dis. 2016, 8(12): E1701-1703.

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

Cao G., Chen C., CHEN Y., ZHEN Z., Zou Y., Liu J., Wu M., Wang R., Liu M., Zhao C., Lu S., Ng M.Y., Tse H.F. and Yiu K.H., Prevalence, clinical characteristics and echocardiography parameters of non-resistant, resistant and refractory hypertension in Chinese., Postgrad Med.. 2017, 129(2): 187-192.

He J.L., Shen X.P., Chen Y., Luo L., Lin Q.S., Zhong Y., Yiu K.H. and Ng M.Y., Evaluation of left ventricular diastolic function by cardiovascular magnetic resonance phase contrast imaging, 2016.

Jim M.H., Fung R.C. and Yiu K.H., Angiographic result of sirolimus-eluting balloon in de novo small coronary artery lesion (ARSENAL)., Int J Cardiol.. 2016, 222: 992-994.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

Tan J.W.C., Lam C.S.P., Kasim S.S., Aw T.C., Abanilla J.M., Chang W.T., Dang V.P., Iboleon D.Y. .M., Mumpuni S.S., Phommintikul A., TA M.C., Topipat P., Yiu K.H. and Cullen L., Asia-Pacific consensus statement on the optimal use of high-sensitivity troponin assays in acute coronary syndromes diagnosis: focus on hs-TnI., Heart Asia.. 2017, 9(1): 81-87.

WANG Y., Liu H.N., ZHEN Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Decreased CPC/EPC counts in type 2 diabetes patients with periodontitis, Journal of Dental Research. 2017, 96 (Spec Iss B): 153.

WANG Y., Liu H.N., Zhen Z., Yiu K.H., Pelekos G., Tse H.F. and Jin L., Periodontal treatment affects gene expression of EPCs in DM patients, Journal of Dental Research. 2017, 96 (Spec Iss A): 2195.

Yiu K.H., Chair: Update in Clinical Practice in Patients with Syncope, APHRS 2016. 2016.

Yiu K.H., Invited Speaker, Coronary Intervention Complication Forum of China, Hangzhou, China 2017, “The clinical application of BRS”, 2017.

Yiu K.H., Invited Speaker, Geriatric Team Meeting Lecture 2017, “ Advanced Clinical treatment of heart failure” , 2017.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

ZHAO D., Yiu K.H., ZHEN Z., Pelekos G. and Jin L., Deterioration of periodontal conditions reflects individual susceptibility to systemic comorbidities?, Journal of Dental Research. 2017, 96 (Spec B): 191.

ZHAO D., Yiu K.H., Zhen Z., Pelekos G. and Jin L., Periodontitis is linked to noncommunicable diseases among dental hospital attendees, Journal of Dental Research. 2017, 96 (Spec Iss A): 0963.

Researcher : Yiu WH

Project Title:	ASN Kidney Week 2013 Annual Meeting ; Tissue Kallikrein Mediates Pro-inflammatory Pathways in Proximal Tubular Epithelial Cells
Investigator(s):	Yiu WH
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2013

Project Title:	ASN Kidney Week 2016; Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy
Investigator(s):	Yiu WH
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

List of Research Outputs

CHAN K.W., Ip T.P., Kwong A.S.K., Lui S.L., Chan G.C.W., Cowling B.J., Yiu W.H., WONG W.L.D., Liu Y., Feng Y., Tan K.C.B., Chan L.Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial, BMJ Open. 2016, 6: e010741.

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Yiu W.H., WONG W.L.D., Wu H., CHAN K.W., Liu Y., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Spleen Tyrosine Kinase Inhibitor Ameliorates Tubular Inflammation in IgA Nephropathy., J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Yue LM

List of Research Outputs

PIAO W., Chau H.W.D., Yue L.M., Kwong Y.L. and Tse E.W.C., Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma, Leukemia. 2017, 31: 522-526.

Researcher : Yuen JCH

List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Researcher : Yuen MAM

List of Research Outputs

Cheung Y.Y., Tang S.C.W., Xu A., Lee C.H.P., Au K.W., Xu L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., An exome-chip association analysis in Chinese subjects reveals a functional missense variant of GCKR that regulates FGF21 levels., Diabetes. 2017, 66(6): 1723-1728.

Cheung Y.Y., Hui Y.L.E., Lee C.H.P., Kwok H.M., Gangwani R.A., Li K.K.W., Chan J.C.W., Woo Y.C., Chow W.S., Yuen M.A.M., Wong L.C., Fong H.Y., Xu A., Wong D.S.H., Sham P.C. and Lam K.S.L., Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes, Investigative Ophthalmology & Visual Science. 2016, 57: 5518-5524.

Lam C.M.J., Lai Y.K.A., Tam C.C.T., Yuen M.A.M., Lam K.S.L. and Ip M.S.M., CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure, Sleep and Breathing. 2017, 21: 377-386.

Lam K.S.L., Cheung C.Y., Lee C.H.P., Tang S.Y.C., Xu A., Au K.W., XU L., Fong H.Y., Kwok H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Cherny S.S., Hai S.H.J.J., Jin Y.L., Cheung B.M.Y., Tan K.C.B., Lam T.H., Tse H.F. and Sham P.C., A functional missense variant of the glucokinase regulator gene (GCKR) is associated with raised FGF21 levels in an exome-chip association study amongst Chinese individuals. , The Endocrine Society’s 99th Annual Meeting, Orlando Apr 2017.. 2017.

Lee C.H.P., Woo Y.C., Chow W.S., Cheung Y.Y., Fong H.Y., Yuen M.A.M., Xu A., Tse H.F. and Lam K.S.L., Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus, Journal of the American Heart Association. 2017, 6: e005344.

Lee C.H.P., Woo Y.C., Chow W.S., Fong H.Y., Yuen M.A.M. and Lam K.S.L., Serum high-sensitivity C-reactive protein level predicts cardiovascular events in Chinese patients with type 2 diabetes with no known cardiovascular disease, The 99th Annual Meeting of the American Endocrine Society, Orlando, USA. 2017.

Lee C.H.P., Shih A.Z.L., Woo Y.C., Fong H.Y., Yuen M.A.M., Chow W.S. and Lam K.S.L., Which creatinine-based estimated glomerular filtration rate equation best predicts all-cause mortality in Chinese subjects with type 2 diabetes?, Diabetes Research and Clinical Practice. 2017, 126: 25-29.

Researcher : Yuen MF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

Researcher : Yuen RMF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

Bazerbachi F., Haffar S., Wang Z., González J.C., Arias-Loste M.T., Crespo J., Darwish-Murad S., Ikram M.A., Petta S., Berzuini A., Prati D., de Lédinghen V., Wong V., Del Poggio P., Chávez-Tapia N.C., Chen Y.P., Cheng P.N., Yuen R.M.F., Das K., Chowdhury A., Caballería L., Fabrellas N., Ginès P., Kumar M., Sarin S.K., Conti F., Andreone P., Sirli R., Cortez-Pinto H., Carvalhana S., Sugihara T., Kim S.U., Parikh P., Chayama K., Corpechot C., Kim K.M., Papatheodoridis G., Alsebaey A., Olynyk J.K., Gan E., Kamath P., Watt K.D. and Murad M.H., Normal values of liver stiffness as measured by transient elastography: pooled individual participant data meta-analysis from 26 studies and 14,883 participants, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S238.

CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., The hepatitis B core protein associates with HBV covalently closed circular DNA via the C-terminal domain and facilitates HBV transcription. [Poster presentation, Hepatology 2016; 64(S1):300A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Chan H.L., Tsang O.T., Hui Y.T., Fung J.Y.Y., Lui G.C., Lai C.L., Wong G.L., Chan K.H., But Y.K.D., Lai M.S., Lao W.C., Chan C., Lam Y.S., Seto W.K.W., Li C., Yuen R.M.F. and Wong V.W., Real-Life Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir in Chronic Hepatitis C Patients in Hong Kong, Journal of Gastroenterology and Hepatology. 2016, 32(6): 1230-33.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of primary biliary cholangitis in Hong Kong: Results from the public healthcare system database from 2000 to 2015. [Poster presentation, Hepatology 2016; 64(S1):198A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., High level of Wisteria floribunda agglutinin-positive human Mac-2 binding protein is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral treatment. Oral Presentation, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11 (Suppl 1): S72.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Predictive factors of hepatocellular carcinoma and transplant-free survival in Chinese patients with primary biliary cholangitis. [Poster presentation, Hepatology 2016; 64(S1):678A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid, Clin Transl Gastroenterol. 2017, 8(6): e100.

Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Prognostic factors for transplant-free survival and external validation of prognostic models in Chinese patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S544.

Cheung K.S., Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy, J Viral Hepat. 2017, 24(8): 654-61.

Cheung K.S., Seto W.K.W., Wong D.K.H., Mak L.Y., Lai C.L. and Yuen R.M.F., Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment, Oncotarget. 2017, 8(29): 47507-17.

Chong C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., Liu F., Seto W.K.W., Lai C.L., Yuen R.M.F. and Wong D.K.H., Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome, Antiviral Res. 2017, 144: 1-7.

Choudhury A., Kumar M., Sharma B.C., Maiwall R., Pamecha V., Moreau R., Chawla Y.K., Duseja A., Mahtab M., Rahman S., Hamid S.S., Butt A.S., Jafri W., Tan S.S., Devarbhavi H., Amarapurkar D., Ning Q., Eapen C.E., Goel A., Kim D.J., Ghazinian H., Shiha G., Lee G.H., Abbas Z., Payawal D.A., Dokmeci A.K., Yuen R.M.F., Lesmana L.A., Sood A., Chan A.C.Y., Lau G.K., Jia J.I.D., Duan Z., Chen Y., Yokosuka Q., Jain P., Bhadoria A.S., Kumar G. and Sarin S.K., Systemic Inflammatory Response Syndrome in Acute on Chronic Liver Failure- Relevance of ‘Golden Window’- a Prospective Study, Journal of Gastroenterology and Hepatology. 2017.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Feld J., Janssen H.L.A., Abbas Z., Elewaut A., Ferenci P., Isakov V., Khan A., Lim S.G., Locarnini S.A., Ono S.K., Sollano J., Spearman C.W., Yeh C.T., Yuen R.M.F. and LeMair A., World Gastroenterology Organisation Global Guideline Hepatitis B, Journal of Clinical Gastroenterology. 2016, 50(9): 691-703.

Feng Y., Yuen R.M.F., Xu Q., Wan X.Y. and Wang D.Q., New Exploration of Chinese Herbal Medicines in Hepatology, Evidence-Based Complementary and Alternative Medicine. 2016, 2016: 1-5.

Fielding R., Lam W.W.T., Liao Q., Lai C.L., Tsang W.H.J., Ip D.K.M. and Yuen R.M.F., Perceptions of cancer risk and self-care practices: comparison of groups at different risk for cancers, Hong Kong Medical Journal. 2016, 22 Suppl 6(6): 8-12.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Sin S.L., Ma K.W., Ng K.C.K., Ng K.C.K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Long Term Outcomes of Entecavir Monotherapy for Chronic Hepatitis B after Liver Transplantation: Results up to 8 years, Hepatology. 2017, 66(4): 1036-44.

Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Ng K.C.K., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L. and Yuen R.M.F., No increase in graft fibrosis for hepatitis B surface antigen positive patients after liver transplantation using entecavir monotherapy, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL). Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S184-S185.

Hui R., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship of hepatic steatosis and hepatitis B viremia: results of a matched case control study, 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. Hepatology International. 2017, 11(Suppl 1): S50.

Hui R.W., Seto W.K.W., Liu S.H.K., Cheung K.S., Mak L.Y., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., The effects of non-alcoholic fatty liver disease on liver fibrosis in chronic hepatitis B patients on nucleoside analogue therapy: results from a matched-case control study. [Poster presentation, Hepatology 2016; 64(S1):915A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Kakuda T., Del Bene E., Yuen R.M.F., Gane E.J., Kim S., Liaw S., Brown N., Klumpp K., Flores F. and Chanda S., Pharmacokinetics (PK) and PK modeling of the first-in- class HBV core inhibitor NVR 3-778 dosed once- (QD) or twice daily (BD) in healthy volunteers (HVs) and HBeAg-positive patients witn chronic HBV infection (CHBV). [Poster presentation, Hepatology 2016; 64(S1): 931A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Kennedy W., Yuen R.M.F., Kim D.J., Weilert F., Chan H.L.Y., Lalezari J., Hwang S.G., Nguyen T., Westland C., Kakuda T., Brown N., Klumpp K., Flores L., Talloen W., Lenz O., Gane E., van Remoortere P., Chandra S. and Fry J., Safety, tolerability, pharmacokinetics and antiviral activity of AL-3778, a first-in-class, HBV core assembly modulator alone and in combination with peginterferon-alpha 2A, in treatment naive HBeAg-positive chronic hepatitis B patients., 26^th Annual Conference of APASL, February 15–19, 2017, Shanghai, China. Hepatology International. 2017, 11(Suppl 1): S7.

Kim K.Y., Estevez J., Israelski D., Baatarkhuu O., Sarantuya T., Narantsetseg S., Nymadawa P., H Le R., Yuen R.M.F., Dusheiko G., Rizzetto M. and Nguyen M.H., Screening and management of viral hepatitis and hepatocellular carcinoma in Mongolia: results from a survey of Mongolian physicians from all major provinces of Mongolia, BMJ Open Gastroenterol. 2016, 3(1): e000119.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

LIU F., Seto W.K.W., Wong D.K.H., Sharma R., Huang F.Y., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Proteomic profiling of plasma proteins associated with spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484-S485.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Li J., Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of IL-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection. [Poster presentation, Hepatology 2016; 64(S1):877A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Li J., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver Int. 2017, 37(9): 1287-94.

Liu S.H.K., Seto W.K.W., Wong D.K.H., Yuen J.C.H., Lam Y.F., Cheung K.S., To W.P.E., Ko K.L.M., Mak L.Y.L., Lai C.L. and Yuen R.M.F., A territory-wide study on the seroprevalence of hepatitis B and C virus in the general population in Hong Kong, China, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S682.

Mak L.Y., Seto W.K.W., Hui R., Fung J.Y.Y., Cheung K.S., Lai C.L. and Yuen R.M.F., Nucleos(t)ide analogue decreased liver stiffness of e-antigen negative chronic hepatitis B (CHB) patients over a 10-year interval, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S251.

Polaris Observatory HCV Collaborators and Yuen R.M.F., Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study, The Lancet Gastroenterology & Hepatology. 2017, 2: 161-176.

Seto W.K.W. and Yuen R.M.F., "Immune tolerance" in HBV infection: danger lurks, Nature Reviews in Gastroenterology and Hepatology. 2016, 13: 627-628.

Seto W.K.W., Wong D.K.H., Chan S.Y.T., Hwang Y.Y.G., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy, The American Journal of Gastroenterology. 2016, 111: 1788-95.

Seto W.K.W., Fung J.Y.Y., Cheung K.S., Mak L.Y., Hui R.W.H., Liu S.H.K., Lai C.L. and Yuen R.M.F., Body-mass index is associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B., Alimentary Pharmacology and Therapeutics. 2016, 44: 1071-1079.

Seto W.K.W., Mak S.K., Chiu W.H.K., Wong H.F., Lee S.F., Cheung K.S., Ho Y.C., Yuen R.M.F. and Leung W.K., Cholangiopathic changes related to recreational use of ketamine: a prospective clinical and radiological evaluation, Digestive Disease Week 2017.

Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung F.N.I., Leung W.K., Cheung K.S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study, Alimentary Pharmacology & Therapeutics. 2016, 45(4): 501-9.

Seto W.K.W., Hui R., Mak L.Y.L., Liu S.H.K., Cheung K.S., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Hepatic steatosis via controlled attenuation parameter measurements and diabetes contribute to persistent liver fibrosis in the era of long-term nucleoside analogue therapy for chronic hepatitis B, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S694-S695.

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lau E.H.Y., Cheung K.S., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study, Hepatology. 2016, 65(5): 1451-61.

Seto W.K.W. and Yuen R.M.F., Hepatitis B virus reactivation during immunosuppressive therapy, In: Griffin M, Immunosuppressives: advancements, applications and analyses. Nova Science, 2017, 41-82.

Seto W.K.W. and Yuen R.M.F., Letter: is body-mass index really associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B? Authors' reply, Aliment Pharmacol Ther. 2017, 45(3): 483.

Seto W.K.W. and Yuen R.M.F., New pharmacological approaches to a functional cure of hepatitis B, Clinical Liver Disease. 2016, 8: 83-88.

Seto W.K.W. and Yuen R.M.F., Non-alcoholic fatty liver disease: emerging perspectives, Journal of Gastroenterology. 2017, 52(2): 164-74.

Seto W.K.W. and Yuen R.M.F., Response to Toyoda et al, Am J Gastroenterol. 2017, 112(6): 970.

Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung F.N.I., Yuen R.M.F. and Leung W.K., Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia, Alimentary Pharmacology & Therapeutics. 2017, 45: 767-776.

Wong D.K.H., Seto W.K.W., Cheung K.S., CHONG C.K., Huang F.Y., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA, Liver International. 2016, 37(7): 995-1001.

Wong D.K.H., CHONG C.K., Cheng C.Y.S., Tsoi S.Y., Huang F.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Identification of hepatitis B X protein regions responsible for the regulation of HBV transcription via histone modification, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S484.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., CHONG C.K., Lai C.L. and Yuen R.M.F., Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein levels correlated with necroinflammation and fibrosis activities in chronic hepatitis B patients. [Poster presentation, Hepatology 2016; 64(S1): 330A], 67^th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, November 11-15, 2016, Boston, USA. 2016.

Yap Y.H.D., Seto W.K.W., Fung J.Y.Y., Chok K.S.H., Chan S.C., Chan G.C.W., Yuen R.M.F. and Chan T.M., Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis, Digestive and Liver Disease. 2016, 49(2): 202-206.

Yuen R.M.F., Chairman of the Thesis Examining Committee for the Oral Examination of MD candidate Prof Lo Wai Kei, The University of Hong Kong, Department of Medicine. 2016.

Yuen R.M.F., Chronic Hepatitis B and C, Pharmacy Department, Hospital Authority, 15^th February 2017, Hong Kong. 2017.

Yuen R.M.F., Chronic hepatitis B infection – Past, Present, Future, Liver Disease Summit, 10 December 2016, Shanghai, China. 2016.

Yuen R.M.F., Clincial significance of occult hepatitis B, Single Topic Conference, Asia Pacifc Association for the Study of the Liver, 17 June 2017, Mongolia. 2017.

Yuen R.M.F., Clinical Application of HBV markers, The 3^rd Asian Workshop for Hepatitis B Virus Markers, 18 February 2017, Shanghai, China. 2017.

Yuen R.M.F., Clinical Implication of Occult Hepatitis B Infection, In: Allain JP, Fu Y, Li C, Raimondo G, Occult Hepatitis B Infection. Science Press, 2016, 178-189.

Yuen R.M.F., Clinical application of HBV markers, Single Topic Conference, Asia Pacifc Association for the Study of the Liver, 17 June 2017, Mongolia. 2017.

Yuen R.M.F., Cornerstones of Hepatitis B: Past, Present, Future, The 4^th International Hepatology Conference, Hepatology Society, Dhaka, Bangladesh, 24 November. 2016.

Yuen R.M.F., Editorial Board Member, Annals of Blood. 2016.

Yuen R.M.F., Hepatology Digest (Periodical), Editorial Board Member. 2016.

Yuen R.M.F., Implication of long-term hepatitis B treatment for HCC development, The 7^th Asia-Pacific Primary Liver Cancer Expert Meeting, Hong Kong, 8 – 10 July. 2016.

Yuen R.M.F., Internal Examiner for Oral Examination of PhD candidate Mr Wong Wai Leung, Dickson, The University of Hong Kong, Department of Medicine. 2016.

Yuen R.M.F., Korean Journal of Hepatology, Editorial Board Member. 2016.

Yuen R.M.F., M2BPGi in hepatitis B related hepatocellular carcinoma, Sysmex Meeting, February 2017, Hong Kong. 2017.

Yuen R.M.F., Management of Chronic Hepatitis B as Informed by the Guidelines and New Treatment Paradigms, Master Class and “Real-Life” Experience with Telbivudine, Dalian, China, 3^rd September. 2016.

Yuen R.M.F., New therapy for chronic hepatitis B, The 6^th Annual Scientific Meeting of Macau Society of Gastroenterology and Hepatology, Macau, 16 – 17 July. 2016.

Yuen R.M.F., Novel Tests for the Management of Chronic Hepatitis B, 29^th Annual Scientific Meeting, 20^th November 2016, Hong Kong. 2016.

Yuen R.M.F., Occult hepatitis B infection, Hepatology Perspective Forum, Seoul, Korea, 12 December . 2016.

Yuen R.M.F., Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen, International Liver Congress, European Association for the Study of the Liver, April 2017, Amsterdam, Netherlands. 2017.

Yuen R.M.F., Liu S.H.K., Chan H.L.Y., Given B.D., Schluep T., Hamilton J., Lai C.L., Locarnini S.A., Lau J.Y., Ferrari C. and Gish R.G., Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen, The International Liver Congress 2017 — 52^nd Annual meeting of the European Association for the Study of the Liver (EASL), Amsterdam, The Netherlands, 19–23 April 2017. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2017, 66(1) Suppl: S27.

Yuen R.M.F., RNAi for Chronic Hepatitis B Virus – Clinical Dat, The 3^rd Central China International Forum on Liver Disease and Infection & National Medical Education Program, Wuhan, China, 23– 25 September. 2016.

Yuen R.M.F., Role of Hepatitis B Core Related Antigen (HBcrAg) on Chronic Hepatitis B, Symposium 2016, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, 8 October. 2016.

Yuen R.M.F., Seven-year treatment outcome of entecavir in a real-world cohort, Online broadcast to Beijing/Guangzhou/Shanghai/Haikou/Xian/ Hangzhou/Jilin, China,11 May 2017, Hong Kong. 2017.

Yuen R.M.F., The significance of HBsAg level in the clinical management of HBV infection, Infectious Disease Courses and Postgraduate Diploma Programme, 16-17 Jul 2016, Department of Microbiology, The University of Hong Kong. 2016.

Yuen R.M.F., The significance of HBsAg level in the clinical management of HBV infection, Infectious Disease Courses and Postgraduate Diploma Programme, Department of Microbiology, The University of Hong Kong, 17 Jul. 2016.

Yuen R.M.F., World Journal of Biological Chemistry, Editorial Board Member. 2016.

Yuen R.M.F., World Journal of Clinical Oncology, Editorial Board Member. 2016.

Zhang A.Y., Lai C.L., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma, J Gastroenterol. 2017.

Researcher : Yung SSY

Project Title:	Fibronectin fragments and isoforms in the pathogenesis of tubulo-interstitial damage in lupus nephritis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Changes in miR-200a and miR-200b expression in mesothelial cells with time on peritoneal dialysis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	The Role of miR-200c in Peritoneal Inflammation and Fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Persistent peritoneal inflammation and its effect on peritoneal fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	ASN Kidney Week 2016 Annual Meeting; MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells
Investigator(s):	Yung SSY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	The role of Extra Domain A Fibronectin in Peritoneal Fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

CHOY H.K., Yung S.S.Y., LI N., Cheung K.F. and Chan D.T.M., EDA+ Fibronectin in Tubulo-interstitial Injury in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Chan D.T.M., Zhang Q., Chau K.M., Chan P.L. and Yung S.S.Y., Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis, ASN Kidney Week 2016.

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding Immunoglobulin G Level Correlates with Clinical and Renal Histological Disease Activity in Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding immunoglobulin level correlates with renal histological features in lupus nephritis, ASN Kidney Week 2016.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D., Chan K.W., Lee C.K., Tang S.O.C. and Chan D.T.M., Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations, Clinical Science. 2017, 131: 653-671.

Li S., Ip K.M., Tang Y.H., Sy K.H.S., Yung S.S.Y., Chan D.T.M., Yang M.S., Shum H.C. and Wong A.S.T., Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice, Journal of Visualized Experiments. 2017.

Yap Y.H.D., Lee P., Yung S.S.Y. and Chan D.T.M., Circulating lymphocyte subsets and disease relapse in lupus nephritis, ASN Kidney Week 2016 Annual Meeting, Chicago, America. 2016.

Yap Y.H.D., Lee P., Yam I.Y.L., Tam H.Y., Wong S., Yung S.S.Y. and Chan D.T.M., Effect of Cyclophosphamide and Mycophelonate Mofetil on Lymphocyte Subsets in Patient with Active Lupus Nephritis, 54th Congress of European Renal Association-European Dialysis and Transplant Association , Madrid, Spain. 2017.

Yung S.S.Y., HO S.K., Chu J.Y.S., Ng C.Y.C., Cheung K.F., Chau K.M. and Chan D.T.M., Anti-dsDNA Antibodies Bind to Ku70 Leading to Increased MCP-1 and TGF-beta1 Expression in Proximal Tubular Epithelial Cells, ISN World Congress of Nephrology 2017.

Yung S.S.Y. and Chan D.T.M., Anti-dsDNA antibodies and resident renal cells — Their putative roles in pathogenesis of renal lesions in lupus nephritis, Clinical Immunology. 2016, pii:S1521-6616(16)30361-30368.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Chu J.Y.S., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Peritoneal Mesothelial Cells, ASN Kidney Week 2016.

Yung S.S.Y., Pathophysiology of Peritoneal Membrane Damage, 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis. 2017.

Yung S.S.Y., Pathophysiology of Peritoneal Membrane Damage, The 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis, Guangzhou, China. 2017.

Yung S.S.Y., Yap Y.H.D. and Chan D.T.M., Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis, F1000Research. 2017, 6: 874.

Yung S.S.Y., Resident Kidney Cells in the Pathogenesis of Lupus Nephritis, 12th International Congress on SLE & 7th Asian Congress on Autoimmunity. 2017.

Yung S.S.Y., Resident Kidney Cells in the Pathogenesis of Lupus Nephritis, The 12th International Congress on SLE & 7th Asian Congress on Autoimmunity, 26-29 March 2017, Melbourne, Australia. 2017.

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : ZHANG R

List of Research Outputs

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Researcher : ZHANG Z

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Zhang Y., ZHANG Z., Cheah K.S.E. and Lian Q., Developing Strategies to Produce Notochord Like Cells from Human ESC/iPSC, ISSCR 2017 Annual Meeting. 2017.

Researcher : ZHEN Z

List of Research Outputs

Agrawal D.E.V.A.N.S.H. .R., Tanabe Y.U.J.I., Weng D.E.S.E.N., Ma A.N.D.R.E.W., Hsu S.T.E.P.H.A.N.I.E., Liao S., ZHEN Z., Zhu Z., Sun C.H.U.A.N.B.O.W.E.N., Dong Z.H.E.N.Y.A., Yang F.E.N.G.Y.U.A.N., Tse H.F., Poon A.D.A. and Ho J.O.H.N. .S., Conformal phased surfaces for wireless powering of bioelectronic microdevices, Nature Biomedical Engineering. 2017, 1: 0043.

CHEN Y., Liu J., Chan D., Sit K.Y., Wong C.K., Ho K.L., Ho L.M., ZHEN Z., Lam Y.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prevalence, predictors and clinical outcome of residual pulmonary hypertension following tricuspid annuloplasty, Journal of the American Heart Association. 2016.

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

Cao G., Chen C., CHEN Y., ZHEN Z., Zou Y., Liu J., Wu M., Wang R., Liu M., Zhao C., Lu S., Ng M.Y., Tse H.F. and Yiu K.H., Prevalence, clinical characteristics and echocardiography parameters of non-resistant, resistant and refractory hypertension in Chinese., Postgrad Med.. 2017, 129(2): 187-192.

Liao S., ZHEN Z., Au K.W., Lai K.W.H., Tse H.F., Rama R.I.T.A., Tsang W.L. and Chen P.E.T.E.R., Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure, JACC: Basic to Translational Science. 2017, Jun;2(3): 270-281.

Liu J., CHEN Y., ZHEN Z., Yeung C.K., Chan C.Y.J., Chan H.H.L., Tse H.F. and Yiu K.H., Relationship between endothelial progenitor cells and arterial stiffness in patients with psoriasis, The Journal of Dermatology. 2016, 43: 888-893.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

WANG Y., Liu H.N., ZHEN Z., Yiu K.H., Tse H.F., Pelekos G. and Jin L., Decreased CPC/EPC counts in type 2 diabetes patients with periodontitis, Journal of Dental Research. 2017, 96 (Spec Iss B): 153.

WANG Y., Liu H.N., Zhen Z., Yiu K.H., Pelekos G., Tse H.F. and Jin L., Periodontal treatment affects gene expression of EPCs in DM patients, Journal of Dental Research. 2017, 96 (Spec Iss A): 2195.

Yiu K.H., Liu J., Ng M.Y., Cheung T., Chung H.Y., CHEN Y., ZHEN Z., Mak K.F., Khong P.L., Lau C.P. and Tse H.F., Ten year progression of coronary artery, carotid artery and aortic calcification in patients with rheumatoid arthritis, ESC CONGRESS 2016.

ZHAO D., Yiu K.H., ZHEN Z., Pelekos G. and Jin L., Deterioration of periodontal conditions reflects individual susceptibility to systemic comorbidities?, Journal of Dental Research. 2017, 96 (Spec B): 191.

ZHAO D., Yiu K.H., Zhen Z., Pelekos G. and Jin L., Periodontitis is linked to noncommunicable diseases among dental hospital attendees, Journal of Dental Research. 2017, 96 (Spec Iss A): 0963.

Researcher : ZHU H

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Researcher : Zhang J

List of Research Outputs

Chen D., Brown R., Liess C., Pokjak A., Xu A., Zhang J., renell M., Jenkins A., Chisholm D., Samocha-Bonet D., Macefield V. and Greenfield J., Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men, Frontiers in Physiology. 2017, 8.

Hui X., Gu P., Zhang J., Wang Y. and Xu A., 2016 Research Output Award, The University of Hong Kong. 2016.

YANG K., Deng H., MAN W.C., SONG E., Zhang J., Luo C., Cheung B.M.Y., Yuen K.Y., Jensen P.S., Irmukhamedov A., Elie A...G...I...M., Vanhoutte P.M.G.R., Xu A., De Mey J.G.R. and Wang Y., Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment, ESC Heart Failure. 2017, 1-13.

Researcher : Zhang Q

List of Research Outputs

Chan D.T.M., Zhang Q., Chau K.M., Chan P.L. and Yung S.S.Y., Acetate from Microbiota Contributes to Tubulo-interstitial Inflammation and Fibrosis in Lupus Nephritis, ASN Kidney Week 2016.

Chan D.T.M., Au K.Y., Cheung K.F., Chau K.M., Zhang Q. and Yung S.S.Y., Serum Lipopolysaccharide, Lipopolysaccharide Binding Protein, and CD14 Levels Correlate with Disease Activity in Patients with Lupus Nephritis, ISN World Congress of Nephrology 2017.

Chan D.T.M., Au K.Y., Zhang Q., Chan P.L., Chau K.M. and Yung S.S.Y., Serum acetate levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Yung S.S.Y., Au K.Y., Cheung K.F., Zhang Q., Yap Y.H.D., Chau K.M. and Chan D.T.M., Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation, Clinical Science. 2016, 131: 49-67.

Yung S.S.Y., Au K.Y., Zhang Q., Chau K.M., Tse W.W. and Chan D.T.M., Serum and intra-renal CD44 levels correlate with disease activity in patients with lupus nephritis, International Congress of Immunology 2016.

Researcher : Zhang Y

Project Title:	Important roles of Rap1/NF-κB signal pathway in regulation of mesenchymal stem cells (MSCs)-secreted cytokines and survival in myocardial infarction
Investigator(s):	Zhang Y, Lian Q
Department:	Ophthalmology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015
Completion Date:	10/2016

List of Research Outputs

JIANG D., GAO F., Zhang Y., Wong D.S., Li Q., Xu G., Yu Z. and Lian Q., Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage., Cell Death Dis. 2016 Nov. 2016, 7(11): e2467.

Jiang D., Gao F., Zhang Y., Wong D.S., Li Q., Tse H.F., Xu G., Yu Z. and Lian Q., Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage., Cell Death Dis. 2016. 2016, 7(11): e2467.

Liang Y., Zhang Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced pluripotent stem cell-derived mesenchymal stem cells exert growth differentiation factor-15-dependent paracrine effect in cigarette smoke medium-induced cardiomyocyte injury, 22nd Medical Research Conference, The University of Hong Kong, Hong Kong Med J. Hong Kong, HK Academy of Medicine Press, 2017, 23: 32.

Poon M.W., Jiang D., Qin P., Zhang Y., Qiu B., Chanda S., Tergaonkar V., Wong I.Y., Yu Z., Tse H.F., Wong D.S. and Lian Q., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn., Sci Rep. 2017. 2017, 7: 41224.

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Zhang Y., ZHANG Z., Cheah K.S.E. and Lian Q., Developing Strategies to Produce Notochord Like Cells from Human ESC/iPSC, ISSCR 2017 Annual Meeting. 2017.

Zhang Y., Yu Z., Jiang D., Liang X., Liao S., Zhang Y., Yue W., Li X., Chiu S.M., Chai Y.H., LIANG Y., Chow Y., Han S., Xu A., Tse H.F. and Lian Q., iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy., Stem Cell Reports. 2016, 7(4): 749-763.

Researcher : Zhen Z

List of Research Outputs

ZHAO D., Yiu K.H., Zhen Z., Pelekos G. and Jin L., Periodontitis is linked to noncommunicable diseases among dental hospital attendees, Journal of Dental Research. 2017, 96 (Spec Iss A): 0963.

Researcher : Zheng C

List of Research Outputs

Lam S.K., LEUNG L.L., Li Y.V., Zheng C. and Ho J.C.M., Combination effects of arsenic trioxide and fibroblast growth factorreceptor inhibitor in squamous cell lung carcinoma, Lung Cancer. 2016, 101: 111-119.

Researcher : Zhou M

List of Research Outputs

Hoo R.L.C., Zhou M., PAN Y., SHU L., Sung Y.J.C., Zhong D., Xia Z., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein (A-FABP) is a potential mediator of heart dysfunction and failure related to obesity, The 11th International Diabetes Federation Western Pacific Region (IDF-WPR) Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD). 2016.

Zhou M., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP)is a potential mediator of heart dysfunction and failure related to obesity, the 11th International Diabetes Federation Western Pacific Region Congress and the 8th Scientific Meeting of the Asian Association for the Study of Diabetes in Taipei, Taiwan . 2016.

Zhou M., Bao Y., LI H., PAN Y., SHU L., Xia Z., Wu D., Vanhoutte P.M.G.R., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clinical Science. 2016.

Researcher : Zhu CF

Project Title:	Deciphering the role of adipose tissue inflammation and adipokines in gut microbiota-induced systemic insulin resistance and metabolic dysregulation
Investigator(s):	Zhu CF, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

List of Research Outputs

Jiang Y.M., Zhao J.M., Li C.Q. and Zhu C.F., 人民卫生出版社, 临床毒理学, 人民卫生出版社, 2016.

WANG Y., TSE M.A., LIU Y., Zhu C.F., Liang Q. and Xu A., High Intensity Exercise: A Multi-beneficial Exercise Modality to Promote Browning of White Adipose Tissue, Reduce Fat Accumulation and Control Metabolic Disease, 10th International Conference on Strength Training, Kyoto, Japan, November 30-December 2, 2016.

Zhu C.F. and Xu A., Marine Collagen Peptides Reduce Endothelial Cell Injury In Diabetic Rats By Inhibiting Apoptosis And The expression Of Coupling Factor 6 And Microparticles, Molecular Medicine Reports. July 21, 2017, 2017, 16: 3947-3957.

Zhu C.F., 非法食品添加剂-三聚氰胺和瘦肉精, In: YueMing Jiang, JinMin Zhao, ChaoQian Li, 临床毒理学, 人民卫生出版社, 1, 2016, 1: P167.

Zhu C.F., 《中国超重/肥胖医学营养治疗专家共识》（2016年版）, In: Wei Chen，cuifeng Zhu et al , 中国医疗保健国际交流促进会营养与代谢管理分会, 中华糖尿病杂志, 2016, 9: 525-540.

Researcher : Zhu H

List of Research Outputs

Researcher : Zhu Z

List of Research Outputs

Agrawal D.E.V.A.N.S.H. .R., Tanabe Y.U.J.I., Weng D.E.S.E.N., Ma A.N.D.R.E.W., Hsu S.T.E.P.H.A.N.I.E., Liao S., ZHEN Z., Zhu Z., Sun C.H.U.A.N.B.O.W.E.N., Dong Z.H.E.N.Y.A., Yang F.E.N.G.Y.U.A.N., Tse H.F., Poon A.D.A. and Ho J.O.H.N. .S., Conformal phased surfaces for wireless powering of bioelectronic microdevices, Nature Biomedical Engineering. 2017, 1: 0043.

Researcher : Zou W

List of Research Outputs

Chan G.C.W., WU H., CHAN K.W., Yiu W.H., Zou W., Huang X.R., Lan H.Y., Lai K.N. and Tang S.C.W., N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. , Nephrology (Carlton). 2017, 2017.

Liu Y., Zou W., WONG W.L.D., CHAN K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Tang S.C.W. and Yiu W.H., Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential in Diabetic Nephropathy, J Am Soc Nephrol . 2016, 27: 701A.

Researcher : Zou Y

List of Research Outputs

CHEN Y., Liu J., Wu M., Lin Q.S., Cao G.Z., Wang R., Liu M.Y., ZHEN Z., Zou Y., Tse H.F. and Yiu K.H., The influence of dipper and non-dipper blood pressure patterns on left ventricular function and peripheral vascular arterial stiffness in patients with hypertension, ESC CONGRESS 2016.

Liu J., Ng M.Y., Cheung T.T., Chung H.Y., Chen Y., Zhen Z., Zou Y., Mak H.K.F., Khong P.L., Lau W.C.S., Tse H.F. and Yiu K.H., Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis, Clinical Rheumatology. 2017.

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