CENTRE FOR GENOMIC SCIENCES
| Researcher : Baum LW |
| List of Research Outputs |
| Baum L.W., Analysis of shared heritability in common disorders of the brain, Science. 2018, 360: eaap8757. |
| Baum L.W., Association Between the Apolipoprotein E Gene Polymorphism and Atherosclerotic Middle Cerebral Artery Stenosis, The Neurologist. 2018, 23: 47-50. |
| Baum L.W., Genetic overlap between epilepsy and schizophrenia: Evidence from cross phenotype analysis in Hong Kong Chinese population, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2018, 177: 86-92. |
| Baum L.W., Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients , Neurology. 2018, 90: e332-e341. |
| Baum L.W., Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis, Neurology Genetics. 2018, 4: e245. |
| Baum L.W., SNP-based HLA allele tagging, imputation and association with antiepileptic drug-induced cutaneous reactions in Hong Kong Han Chinese, The Pharmacogenomics Journal. 2018, 18: 340-346. |
| Researcher : Cherny SS |
| Project Title: | Exome sequencing of mesial temporal lobe epilepsy with hippocampal sclerosis in parent-offspring trios |
| Investigator(s): | Cherny SS, Sham PC |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| List of Research Outputs |
| Lam W.Y., Tang S.M., Sham P.C., Tam P.K.H., Cherny S.S. and Garcia-Barcelo M.M., Evaluation of candidate genes for Hirschsprung disease using targeted sequencing, The American Society of Human Genetics Annual Meeting, Orlando, U.S.A., 17-21 October 2017. |
| Researcher : Li J |
| List of Research Outputs |
| Poon N.Y.E., Hao B., Guan D., Li J., Lu J., Yang Y., Wu B., Webb S.E., WU C.M., Miller A.L., Liang Y., Yao X., Wang J., Yan B. and Boheler K.R., Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, Cardiovascular Research. London, Oxford, 2018, 114: 894-906. |
| XU H. and Li J., New Insight into Functional Analysis of Structural Variants in Cancer Genome, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017. |
| Researcher : Lin C |
| List of Research Outputs |
| Cheng B.Y., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Ma S.T., Lin C., Lo C.L.R., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Res . 2018. |
| MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Researcher : Mak SHT |
| List of Research Outputs |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Mak S.H.T., PORSCH R.M., CHOI S.W., Zhou X. and Sham P.C., Polygenic scores via penalized regression on summary statistics, Genetic Epidemiology. 2017, 41: 469-480. |
| Researcher : Porsch RM |
| List of Research Outputs |
| Wisnumurti D.W., Sribudiani Y.S., Porsch R.M., Maskoen A.M., Rahayuningsih L.A., Rahayuningsih S.R., Asni E.A., Sleutels F.S., Kockx C.K., van Ijcken W.I., Sukadi A.S. and Achmad T.A., UGT1A1 Genetic Variations and a Haplotype Associated with Neonatal Hyperbilirubinemia in Indonesian Population , BioMed Research International. 2018, 2018: 1-11. |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Partner State Key Laboratory of Brain and Cognitive Sciences |
| Investigator(s): | Sham PC, So KF, Tan L |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 10/2008 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | Genomics |
| Investigator(s): | Sham PC, Chin FYL, Leung FCC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Cross Cultural Differences in Biased Cognition |
| Investigator(s): | Sham PC, Chen EYH, Toulopoulou T |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | ESRC/RGC Joint Research Scheme |
| Start Date: | 09/2013 |
| Completion Date: | 08/2017 |
| Project Title: | A novel computational framework to identify transcription factor-DNA interaction for cancer genomics |
| Investigator(s): | Sham PC, Yao KM, Wong MP, Wang JJ |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2014 |
| Completion Date: | 07/2017 |
| Project Title: | Schizophrenia-related de novo and compound heterozygous mutations |
| Investigator(s): | Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Method and software tool for estimating and dissecting the heritability of complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Project Title: | Establishment of Third Generation Sequencing Core Facility |
| Investigator(s): | Sham PC, Leung SY, Peiris JSM, Poon LML, Woo PCY, Yuen KY |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 04/2017 |
| Project Title: | Genetic Variation and Genomic Architecture in Development, Health and Disease |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2017 |
| Project Title: | Integrating functional annotation and statistical information in novel set-based rare-variants association tests for complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M, Tang SM |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | New-generation high-performance computer cluster for studying the role of complex genomic variations in development and disease |
| Investigator(s): | Sham PC, Cheah KSE, Garcia-Barcelo MM, Ng IOL, Ngan ESW, Yang W |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lam W.Y., Tang S.M., Sham P.C., Tam P.K.H., Cherny S.S. and Garcia-Barcelo M.M., Evaluation of candidate genes for Hirschsprung disease using targeted sequencing, The American Society of Human Genetics Annual Meeting, Orlando, U.S.A., 17-21 October 2017. |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Mak S.H.T., PORSCH R.M., CHOI S.W., Zhou X. and Sham P.C., Polygenic scores via penalized regression on summary statistics, Genetic Epidemiology. 2017, 41: 469-480. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| So H.C., Chau C.K.L., Chiu W.T., Ho K.S., Lo C.P., Yim S.H.Y. and Sham P.C., Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry, Nature Neuroscience. 2017, 20: 1342-1349. |
| Teng L.L., Yeung M.L., Chan E., Jia L., Lin C., Huang Y., Tse H., Wong S.S.Y., Sham P.C., Lau S.K.P. and Woo P.C.Y., Pacbio But Not Illumina Technology Can Achieve Fast, Accurate And Complete Closure Of The High Gc, Complex Burkholderia Pseudomallei Two-chromosome Genome, Frontiers in Microbiology. 2017, 7: 4536. |
| Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3. |
| Researcher : Wang JJ |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Yan B., Guan D., Wang C., Wang J.J., He B., Qin J., Boheler K.R., Lu A., Zhang G. and Zhu H., An integrative method to decode regulatory logics in gene transcription, Nature Communications. 2017, 8: 1044. |
| Yan B., Wang P., Wang J.J. and Boheler K.R., Discovery of surface target proteins linking drugs, molecular markers, gene regulation, protein networks and disease by using a web-based platform Targets-search, In: Boheler, Kenneth R., Gundry, Rebekah L, Methods in Molecular Biology. Germany, Springer, 2017, 331-344. |
| Researcher : Wang P |
| List of Research Outputs |
| Yan B., Wang P., Wang J.J. and Boheler K.R., Discovery of surface target proteins linking drugs, molecular markers, gene regulation, protein networks and disease by using a web-based platform Targets-search, In: Boheler, Kenneth R., Gundry, Rebekah L, Methods in Molecular Biology. Germany, Springer, 2017, 331-344. |