DEPT OF MEDICINE
| Researcher : Au KW |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Researcher : Au KY |
| List of Research Outputs |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Yang L.H., Chik S.C.C., Au K.Y. and Chan G.C.F., Evaluation of anti-inflammatory activity of novel synthesized phenylpropanoid esters, International Journal of Drug Research and Technology. 2018, 8: 1. |
| Researcher : Au YLE |
| List of Research Outputs |
| Au Y.L.E., Ip W.K., Lau W.C.S. and Chan Y.T.E., Evaluation of a multiplex flow immunoassay versus conventional assays in detecting autoantibodies in systemic lupus erythematosus, Hong Kong Medical Journal. 2018. |
| Researcher : Bu L |
| Project Title: | Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans |
| Investigator(s): | Bu L, Li RA |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2012 |
| Researcher : But YKD |
| List of Research Outputs |
| Hui Y.T., Wong G., Liu S.D., Liu S.H.K., Ma Y.K., But Y.K.D., .... ........, Yuen R.M.F. and Wong V.W.S., Territory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong, Journal of Gastroenterology and Hepatology. 2017, 32: 158-159. |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Researcher : CHEN L |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605. |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749. |
| Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018. |
| Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75. |
| Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35. |
| Leung W.K., Wong O.L., Chan E.W., Wong A., Yeung K.F., Chen L., Wong I. and Cheung K.S.M., Top Abstract Award, 25th United European Gastroenterology Week, Barcelona, Spain , United European Gastroenterology. 2017. |
| Researcher : CHEN Y |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Researcher : CHIU SM |
| List of Research Outputs |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : CHOW JX |
| List of Research Outputs |
| Lam K.Y.I., CHOW J.X., Lau W.C.S. and Chan V.S.F., MicroRNA-mediated immune regulation in rheumatic diseases, Cancer Letters. 2018, 431: 201-212. |
| Researcher : CUI Y |
| List of Research Outputs |
| Mak J.C.W., CUI Y., Liu W.K.K., Liang Y. and Ip M.S.M., Selegiline suppressed cigarette smoke-induced oxidative stress and inflammation via MAO-B inhibition in rat lung, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A4752. |
| Researcher : Cai Z |
| List of Research Outputs |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Researcher : Chai YH |
| List of Research Outputs |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : Chak WL |
| List of Research Outputs |
| Cheung C.Y.S., Ma K.M.M., Chak W.L. and Tang S.C.W., Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong, Medicine (Baltimore). 2017, 96(38): e8077. |
| Cheung C.Y.S., Ma K.M.M., Chak W.L., Chau K.F. and Tang S.C.W., Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. , Oncotarget. 2017, 8(27): 44833-44841. |
| Researcher : Chan CYJ |
| Project Title: | Registry of Severe Cutaneous Adverse Drug Reactions and Epidemiological study in Hong Kong (RESCUE-HK) |
| Investigator(s): | Chan CYJ, Cheung BMY, Wong ICK, Cheung CL, Yeung CK, Shih KC, Chan CLR |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Researcher : Chan DTM |
| Project Title: | Gut Microbiota Products in the Pathogenesis of Lupus Nephritis |
| Investigator(s): | Chan DTM, Yung SSY, Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Project Title: | The role of Ku70 and Ku80 in the pathogenesis of lupus nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The Role of Major Vault Protein in Tubulo-interstitial Injury during Lupus Nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | ASN Kidney Week 2015 Annual Meeting; Serum Acetate and Lipopolysaccharide Levels Correlate with Disease Activity in Patients with Lupus Nephritis |
| Investigator(s): | Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2015 |
| Project Title: | The roles of lipopolysaccharide, lipopolysaccharide binding protein and CD14 in the pathogenesis of lupus nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | The role of lysophosphatidic acid in the pathogenesis of lupus nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Completion Date: | 04/2018 |
| Project Title: | Acetate in the Pathogenesis of Lupus Nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Role of Major Vault Protein in Fibrotic Processes in Human Mesangial Cells and Proximal Renal Tubular Epithelial Cells |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | Major Vault Protein in Tubulo-interstitial Damage of Chronic Kidney Disease |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | The Role of Lipopolysaccharide on CD44-mediated Kidney Inflammation and Fibrosis in Lupus Nephritis |
| Investigator(s): | Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Boedigheimer M.J., Martin D.A., Amoura Z., Sanchez-Guerrero J., Romero-Diaz J., Kivitz A., Aranow C., Chan D.T.M., Chong Y.B., Chiu K., Wang C., Sohn W., Arnold G.E., Damore M.A., Welcher A.A., Sullivan B.A., Kotzin B.L. and Chung J.B., Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis, Lupus Science & Medicine. 2017, 4(1): e000226. |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Chan D.T.M., Debate on the use of extended criteria donors, at the 15th Congress of the Asian Society of Transplantation, 27-30 November 2017, Cebu, Philippines. 2017. |
| Chan D.T.M., Hepatitis B and the Kidnay, at the 2018 Asian Pacific Congress of Nephrology, 27-31 March 2018, Beijing, China. 2018. |
| Chan D.T.M., Hepatology Practised by a Nephrologist, at the Hong Kong Medical Forum, organized by the Department of Medicine, University of Hong Kong, 5 May 2018, Hong Kong. 2018. |
| Chan D.T.M., Immunopathogenesis of Lupus Nephritis, at tLupus for the Internist meting organized by the Philippine Rheumatology Association, 3 May 2018, Manila, Philippines. 2018. |
| Chan D.T.M., Kidney in Lupus - Looking beyond ISN/RPS Classification, at the Lupus Initiative Kolkata International Lupus Meet 2018, 20-21 January 2018, Kolkata, India. 2018. |
| Chan D.T.M., Lupus Nephritis - Opus 2, at the 2017 Annual Scientific Meeting of Hong Kong Society of Nephrology, 1 Oct 2017, Hong Kong. 2017. |
| Chan D.T.M., Lupus Nephritis, at the KDIGO (Kidney Disease Improving Global Outcomes) Controversies Conference on Glomerular Diseases, 16-19 November 2017, Singapore. 2017. |
| Chan D.T.M., Management of CMV infection after kidney transplantation, at the 15th Congress of the Asian Society of Transplantation, 27-30 November 2017, Cebu, Philippines. 2017. |
| Chan D.T.M., Management of lupus nephritis, at Lupus for the Internist meeting organized by the Philippine Rheumatology Association, 3 May 2018, Manila, Philippines. 2018. |
| Chan D.T.M., Planning a Clinical Trial, at the 2018 Asian Pacific Congress of Nephrology, 27-31 March 2018, Beijing, China. 2018. |
| Chan D.T.M., Recent advances in the diagnosis and treatment of lupus nephritis, at the 2nd International Congress of Chinese Nephrologists, 8-10 December 2017, Taipei. 2017. |
| Chan D.T.M., Renal Lupus - Better understanding of pathogenesis and new horizons in therapy, at the Lupus Initiative Kolkata International Lupus Meet 2018, 20-21 January 2018, Kolkata, India. 2018. |
| Chan D.T.M., Treatment of lupus nephritis - current status and future directions, at the 19th Congress of the Asia Pacific League of Associations for Rheumatology (APLAR), 16-20 October 2017, Dubai, UAE. 2017. |
| Chan K.Y., Yap Y.H.D., Yip T., Sham M.K., Lui S.L. and Chan D.T.M., Palliative Care Consultation in Advanced Chronic Kidney Disease with Pain, J Palliat Med. 2018, 21: 809-814. |
| Chao L.I., Yap Y.H.D., Chan G., Wen Y., LI H., Tang C., Li X.M., Li X.W. and Chan D.T.M., Clinical Characteristics and outcomes of lupus nephritis patients with kidney biopsy showing thrombotic microangiopathy, 55th ERA-EDTA Congress 2018, Copenhagen, Denmark . 2018. |
| Kwan P.Y.L., Mok M.Y., Choy C.B.Y. and Chan D.T.M., Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet, Nephrology. 2017, 22(10): 821-822. |
| Lv J., Zhang H., Wong M.G., Jardine M.J., Hladunewich M., Jha V., Monagham H., Zhao M., Barbour S., Reich H., Cattran D., Glassock R., Levin A., Wheeler D., Woodward M., Billot L., Chan D.T.M., Liu Z.H., Johnson D.W., Cass A., Feehally J., Floege J., Remuzzi G., Wu Y., Agrawal R., Wang H.Y., Perkovic V. and TESTING Study Group .., Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy, JAMA. 2017, 318(5): 432-442. |
| Ma J., KALA S., Yung S.S.Y., Chan D.T.M., Cao Y., Jiang Y., Liu X., Giorgio S., Peng L. and Wong A.S.T., Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70 S6K with Dendrimer Nanovector-Based siRNA Delivery, Molecular Therapy. 2018, 26: 70-83. |
| Ma M.K., Law H.K., Tse K.S., Chan K.W., Chan G.C., Yap Y.H.D., Mok M.M., Kwan L.P., Tang S.C.W., Choy B.Y. and Chan D.T.M., Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis, Int J Urol. 2018, 2018: 25(5):450-455. |
| Ma M.K.M., Yung S.S.Y. and Chan D.T.M., mTOR inhibition and kidney diseases, Transplantation. 2018, 102: S32-40. |
| Shum H.P., Chan K.C., Tam C.W., Yan W.W. and Chan D.T.M., Impact of renal replacement therapy on survival in patients with KDIGO Stage 3 acute kidney injury: A propensity score matched analysis, Nephrology. 2017, Epub ahead of print. |
| Wong C.K.H., Chen J.Y., Fung S.K.S., Lo W.K., Lui S.L., Chan D.T.M., Cheng Y.L., Kong I.L.L., Wan Y.F. and Lam C.L.K., Health-related Quality of Life and Health Utility of Chinese Patients Undergoing Nocturnal Home Haemodialysis in comparison to Other Modes of Dialysis, Nephrology. 2018. |
| Yap Y.H.D., Thong K.M., Yung S.S.Y., Tang C., Ma B.M. and Chan D.T.M., Antiphospholipid antibodies in lupus nephritis – a single centre experience, 55th ERA-EDTA Congress 2018, Copenhagen, Denmark. 2018. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Yap Y.H.D., Kwan P.Y.L., Ma K.M., Mok M.Y.M., Chan G.C.W. and Chan D.T.M., Preemptive immunosuppressive treatment for asymptomatic serological reactivation may reduce renal flares in patients with lupus nephritis: a cohort study., Nephrol Dial Transplant. 2018. |
| Yung S.S.Y., Chu J.Y.S., Chau K.M., Cheung K.F. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Human Peritoneal Mesothelial Cells, UK Kidney Week 2017. |
| Researcher : Chan GCW |
| List of Research Outputs |
| Chan G.C.W., Lee C.H.P., Kwan P.Y.L., Yip T.P.S. and Tang S.C.W., Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism, Nephrology. 2017, 22: 572-572. |
| Chan G.C.W. and Tang S.C.W., SGLT2 Inhibitor Empagliflozin: Finally at the Latter Stage of Understanding., Kidney Int (in press). 2017, 2017. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Researcher : Chan HHL |
| Project Title: | The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota |
| Investigator(s): | Chan HLH, Lam LK |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2000 |
| Project Title: | The use of vascular lasers in the treatment of port wine stain in chinese |
| Investigator(s): | Chan HLH, Wei WI |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 11/2001 |
| Researcher : Chan HWF |
| List of Research Outputs |
| Lam T.P. and Chan H.W.F., Preventive geriatrics, In: Kong TK, The Hong Kong Geriatrics Society Curriculum in Geriatric Medicine, 2nd edition. 2017. |
| Luk J.K.H., Lau H.P., Ng W.C., Chan W.K., Fong C.H.C., Chan C.L.W., Chow A.Y.M. and Chan H.W.F., Understanding the facilitators and barriers of ACP with frail elderly: The experience of a geriatric outreach team in Hong Kong, 12th Asia Pacific Hospice Conference. 2017. |
| Wong T.M., Leung F.K.L., Lau T.W., Fang C.X., Chan H.W.F. and Wu J., Effectiveness of a Day Rehabilitation Program in Improving Functional Outcome and Reducing Mortality and Readmission of Elderly Patients With Fragility Hip Fractures, Geriatric Orthopaedic Surgery & Rehabilitation. 2018, 9: 1-8. |
| Researcher : Chan JCK |
| Project Title: | Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital |
| Investigator(s): | Chan JCK, Lam WK |
| Department: | Medicine |
| Source(s) of Funding: | Health Services Research Fund - Full Grants |
| Start Date: | 07/1995 |
| Researcher : Chan KH |
| Project Title: | Clinical outcome of multiple sclerosis in Hong Kong Chinese |
| Investigator(s): | Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Bayer Pharmaceuticals Ltd. - General Award |
| Start Date: | 01/2008 |
| Project Title: | Study of clinical and immunological characteristics of local multiple sclerosis patients |
| Investigator(s): | Chan KH, Ho SL |
| Department: | Medicine |
| Source(s) of Funding: | Bayer Pharmaceuticals Ltd. - General Award |
| Start Date: | 03/2008 |
| Project Title: | The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica |
| Investigator(s): | Chan KH, Ho WL |
| Department: | Medicine |
| Source(s) of Funding: | Bayer Pharmaceuticals Ltd. - General Award |
| Start Date: | 04/2009 |
| Project Title: | Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity |
| Investigator(s): | Chan KH, Lam KSL, Xu A, Ho SL, Ho WL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2010 |
| Project Title: | Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica |
| Investigator(s): | Chan KH, Ho WL |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 06/2011 |
| Project Title: | Investigation of adiponectin gene therapy in an animal model of Alzheimer's disease |
| Investigator(s): | Chan KH, Ng CL, Chung SK |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Project Title: | Longitudinal MRI Study of local multiple sclerosis patients using quantitative conventional MRI and advanced MRI techniques |
| Investigator(s): | Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Novartis Pharmaceuticals (HK) Ltd |
| Start Date: | 01/2017 |
| Project Title: | Pathogenicity of AQP4-IgG autoantibodies in neuromyeltiis optica: role of astrocytic activation in the absence of complement activation |
| Investigator(s): | Chan KH, Yick LW |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2018 |
| Project Title: | Research for effective treatments for Alzhimer's disease |
| Investigator(s): | Chan KH, Chung SK |
| Department: | Medicine |
| Source(s) of Funding: | Chan Kin Shing Charitable Trust |
| Start Date: | 10/2017 |
| Project Title: | Myeloperoxidase Inhibition ameliorates neuroinflammation in Alzheimer’s disease |
| Investigator(s): | Chan KH, Ng CL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Chan K.H. and Yick L.W., Aquaporin-4 IgG autoantibodies from neuromyelitis optica spectrum disorder patients cause complement-independent spinal cord pathologies and motor deficits in mice, European Academy of Neurology Annual Meeting 2018. |
| Chan K.H., Case Sharing of Local CIDP Patients, CSL Behring Asia Pacific Advisory Board in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). 2017. |
| Chan K.H., Chairmanship in 2017 UCB APAC MS Summit. Pathfinder for Personalized Treatment and Care in MS. Taiwan 2017, UCB Pharmaceutical. 2017. |
| Chan K.H., Chairmanship of Poster Sessions in International Alzheimer's Disease Conference 2017 Advances in Dementia Research and Care, HKU, CU, HKBU, HKST Parks Corporation, Lingnan University, CUHK, EUHK, HKPU, HKUST. 2017. |
| Chan K.H., Consultancy at CSL Behring Asia Pacific Advisory Board in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), CSL Behring. 2017. |
| Chan K.H., GRF Incentive Award, Department of Medicine, LKS Faculty of Medicine, HKU. 2017. |
| Chan K.H., Immunopathology of MS: Role of B & T cell, 1st Train the Trainer (TTT) for MS experts . 2018. |
| Chan K.H., Invited Chairman, APAC MS Summit. Pathfinder for Personalized Treatment and Care in MS. Taiwan 2017. 2017. |
| Chan K.H., Lee R., Lau G.K.K. and Loong F., Orbital Ectopic Lymphoid Follicles with Germinal Centers in Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorders, Frontiers in Immunology. 2018, 8: 1947. |
| Chan K.H. and Yick L.W., Passive transfer of human aquaporin-4 IgG autoantibodies causes complement-independent spinal cord immunopathologies in mice, American Academy of Neurology 70th Annual Meeting. 2018. |
| Lee C.Y., Mak H.K.F., Chiu P.W., Chang H.C.C., Barkhof F. and Chan K.H., Differential brainstem atrophy patterns in multiple sclerosis and neuromyelitis optica spectrum disorders, Journal of Magnetic Resonance Imaging. US, Wiley, 2017. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| Yick L.W., Ma K.F.O., Ng C.L., Kwan S.C. and Chan K.H., Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice, Frontiers in Immunology . 2018, 9: 1438. |
| Researcher : Chan KW |
| List of Research Outputs |
| Ma M.K., Law H.K., Tse K.S., Chan K.W., Chan G.C., Yap Y.H.D., Mok M.M., Kwan L.P., Tang S.C.W., Choy B.Y. and Chan D.T.M., Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis, Int J Urol. 2018, 2018: 25(5):450-455. |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Chan LY |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Researcher : Chan MMW |
| Project Title: | A surveillance program of tuberculosis in old age homes in Hong Kong |
| Investigator(s): | Chan MMW, Chu LW, Lam WK |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2001 |
| Project Title: | A surveillance program of tuberculosis in old age homes in Hong Kong |
| Investigator(s): | Chan MMW, Chu LW, Lam WK |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2004 |
| Researcher : Chan PHM |
| Project Title: | Left Atrial Volume by Computed Tomography in prediction of New onset Atrial Fibrillation |
| Investigator(s): | Chan PHM, Siu DCW, She HLH |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease |
| Investigator(s): | Chan PHM, She HLH, Tse HF, Chan WS, Siu DCW, Cheung CWS |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk |
| Investigator(s): | Chan PHM, Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2016 |
| Project Title: | Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management |
| Investigator(s): | Chan PHM, Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2016 |
| Project Title: | Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease |
| Investigator(s): | Chan PHM, Ng MY, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2016 |
| Project Title: | Prospective evaluation of the impact of Drug-Coated Balloon in the management of true coronary bifurcation disease |
| Investigator(s): | Chan PHM, Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| List of Research Outputs |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Fang J.X., Fang B.X., Lam C.C., Chan P.H.M., Tam C.C. and Siu D.C.W., Extrinsic pulmonary artery compression mimicking acute pulmonary embolism, Clinical Case Reports. 2017, 5: 1591-1593. |
| HUANG D., Wong C.L., Cheng K.W., Chan P.H.M., Yue W.S., Wong C.K., Ho C.W., Wong I.C.K., Chan E.W. and Siu D.C.W., Impact of provision of time in therapeutic range value on anticoagulation management in atrial fibrillation patients on warfarin, Postgraduate Medical Journal. 2018, 94: 207-211. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| HUANG D., Chan P.H.M., She H.L., Wong C.K., Ho C.W., Cheng Y.Y., Chan E.W., Chiang C.E. and Siu D.C.W., Secular trends and etiologies of venous thromboembolism in Chinese from 2004 to 2016, Thrombosis Research. 2018, 166: 80-85. |
| Hai S.H.J.J., Un K.C., Wong C.K., Wong K.L., Zhang Z.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Prognostic implications of early monomorphic and non–monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome, Heart Rhythm. 2018, 15: 822-829. |
| Poh M.Z., Poh Y.C., Chan P.H.M., Wong C.K., Pun L., Leung W.W.C., Wong Y.F., Wong M.M.Y., Chu D.W.S. and Siu D.C.W., Diagnostic assessment of a deep learning system for detecting atrial fibrillation in pulse waveforms, Heart. 2018, heartjnl-2018-313147. |
| Wong C.K., Chan P.H.M., Lam C.C.S., Kwok O.H., Lam Y.Y. and Siu D.C.W., WATCHMAN device-related thrombus successfully treated with apixaban, Medicine. 2017, 96: e8693. |
| Researcher : Chan SYT |
| List of Research Outputs |
| Chan S.Y.T., Li J., Loong F., Khong P.L., Tse E.W.C. and Kwong Y.L., PD1 blockade with low-dose nivolumab in NK/T cell lymphoma failing l-asparaginase: efficacy and safety, Annals of Hematology. 2017. |
| Hwang Y.Y.G., Singh G.H.H., Chan S.Y.T., Leung G.M.K., Cheung C.Y.M. and Kwong Y.L., Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting, Hematology. 2018, 1-6. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Researcher : Chan TCI |
| List of Research Outputs |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Researcher : Chan VNY |
| Project Title: | Hepatitis B virus array for genotyping and mutation detection |
| Investigator(s): | Chan VNY, Lai CL, Chan K, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2006 |
| Researcher : Chan VSF |
| Project Title: | Regulation of inflammasome activation in systemic lupus erythematosus |
| Investigator(s): | Chan VSF, Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2017 |
| List of Research Outputs |
| Lam K.Y.I., CHOW J.X., Lau W.C.S. and Chan V.S.F., MicroRNA-mediated immune regulation in rheumatic diseases, Cancer Letters. 2018, 431: 201-212. |
| Lam K.Y.I., Chan V.S.F. and Lau W.C.S., Treatment modulation of transcriptional profiles in lupus nephritic patients , 23rd Medical Research Conference. 2018, 24. |
| Zhang H., Lam K.H., Lam W.W.L., Wong Y.Y.S., Chan V.S.F. and Au S.W.N., A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori, Molecular Microbiology. 2017. |
| Researcher : Chan YTE |
| List of Research Outputs |
| Au Y.L.E., Ip W.K., Lau W.C.S. and Chan Y.T.E., Evaluation of a multiplex flow immunoassay versus conventional assays in detecting autoantibodies in systemic lupus erythematosus, Hong Kong Medical Journal. 2018. |
| Researcher : Chan YY |
| List of Research Outputs |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Chang SKR |
| List of Research Outputs |
| Pang S.Y.Y., Teo K.C., Hsu J.S., Chang S.K.R., Li M., Sham P.C. and Ho S.L., The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review, Translational Neurodegeneration. United Kingdom, BioMed Central, 2017, 6: 27. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Cognitive impairments in chronic temporal lobe epilepsy patients: an event-related potential study of prospective memory, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 60. |
| Researcher : Chau KF |
| List of Research Outputs |
| Cheung C.Y.S., Ma K.M.M., Chak W.L., Chau K.F. and Tang S.C.W., Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. , Oncotarget. 2017, 8(27): 44833-44841. |
| Researcher : Chau KM |
| List of Research Outputs |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Yung S.S.Y., Chu J.Y.S., Chau K.M., Cheung K.F. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Human Peritoneal Mesothelial Cells, UK Kidney Week 2017. |
| Researcher : Chen L |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605. |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749. |
| Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018. |
| Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75. |
| Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35. |
| Leung W.K., Wong O.L., Chan E.W., Wong A., Yeung K.F., Chen L., Wong I. and Cheung K.S.M., Top Abstract Award, 25th United European Gastroenterology Week, Barcelona, Spain , United European Gastroenterology. 2017. |
| Researcher : Chen WH |
| Project Title: | Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition |
| Investigator(s): | Chen WH, Lau CP |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/2001 |
| Project Title: | A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention |
| Investigator(s): | Chen WH, Lau CP |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention |
| Investigator(s): | Chen WH, Lau CP |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Researcher : Chen Y |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Researcher : Cheng CTK |
| List of Research Outputs |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Researcher : Cheng CW |
| List of Research Outputs |
| Cheng C.W., LEONG K.W., NG Y.M., Kwong Y.L. and Tse E.W.C., The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27, Journal of Biological Chemistry. 2017, 292: 21431-21441. |
| Researcher : Cheng KY |
| Project Title: | The adaptor protein APPL2 as a physiological modulator of pancreatic β-cell functions in mice |
| Investigator(s): | Cheng KY, Cheung YY |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in adipose tissues |
| Investigator(s): | Cheng KY, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | APPL2 as a key mediator of white-to-beige fat transdifferentiation |
| Investigator(s): | Cheng KY, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | The role of adipocyte turnover in regulation of systemic energy and glucose homeostasis |
| Investigator(s): | Cheng KY, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Cheng Y |
| List of Research Outputs |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Researcher : Cheng YY |
| Project Title: | The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma |
| Investigator(s): | Cheng YY, Tse EWC |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Cheung BMY |
| Project Title: | Accelerating the Development of Pharmacogenomics at HKU through a Systems Biology Approach |
| Investigator(s): | Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Innovative Research Grants |
| Start Date: | 07/2013 |
| Project Title: | The 10th Scientific Conference on Cardiovascular Science Across the Strait |
| Investigator(s): | Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 11/2015 |
| Project Title: | A metabolomic study to reveal how phytosterols improve the lipid profile |
| Investigator(s): | Cheung BMY, Cheung CL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Completion Date: | 12/2017 |
| Project Title: | 28th International Symposium on Atherosclerosis; Increase in Cardiovascular Events in Patients Treated with CETP Inhibitors is Associated with rs1967309 SNP in ADCY9 Gene |
| Investigator(s): | Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Chau P.H., Yeung M.N., Cheung S.T., Kong C.H.M., Chow S., Lo W.T., Yuen M.H. and Cheung B.M.Y., Salt sensitivity of blood pressure among older Chinese people in Hong Kong, Poster presented at the 7th Hong Kong International Nursing Forum. Hong Kong, China, 18-19 December 2017 . 2017. |
| Cheung B.M.Y., Fake peer review - too good to be true, Postgraduate Medical Journal. 2017, 93: 498-498. |
| Cheung B.M.Y., Hypertension: a weighty problem in children, Postgraduate Medical Journal. 2017, postgradmedj-2016-134341. |
| Cheung B.M.Y., Medical student research: is it necessary and beneficial?, Postgraduate Medical Journal. 2018, 94: 317-317. |
| Cheung B.M.Y. and Cheung T.T., No lead is better than a little lead, Postgraduate Medical Journal. 2017, 93: 512-512. |
| Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J., Li W., Zhao X.M., Wang Z. and Mu S., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants, Clinical Therapeutics. 2018, 40: 719-732.e1. |
| FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs, International Journal of Cardiology. 2018, 254: 291-296. |
| FU S.N., Dao M.C., Luk W., Ho I.S.F., Lam M.C.H., Cheung S.K., Wong C.K.H. and Cheung B.M.Y., Do Patients with Uncontrolled Hypertension Sustain High Quality Self-Blood Pressure Monitoring after an Interactive Workshop, 2017 Society for Academic Primary Care (SAPC) Annual Scientific Meeting. 2017. |
| Guo Y., Cao B., Cai C.Y., Cheng K.K.Y. and Cheung B.M.Y., Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis, Acta Diabetologica. 2017. |
| Ko K.L., Liu C. and Cheung B.M.Y., Severe bradycardia associated with crizotinib, Postgraduate Medical Journal. 2017, postgradmedj-2017-135213. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgrad Med J. 2017, 93 (1101): 373-375. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgraduate Medical Journal. 2017, 93: 373-375. |
| Muhammad S., Humaira K., Muhammad F., Mahmood A., Rizwan A.Q., Waseem S., Pakeeza A.S., Cheung B.M.Y. and Ghazala K.R., Association of Intestinal Fatty Acid Binding Protein (FABP2) Polymorphism with Metabolic Syndrome Risk, Pakistan J. Zool. 2018, 50 (Iss. 1): 175-181. |
| Wong C.K.H., Wu O. and Cheung B.M.Y., Towards a Transparent, Credible, Evidence-Based Decision-Making Process of New Drug Listing on the Hong Kong Hospital Authority Drug Formulary: Challenges and Suggestions, Applied Health Economics and Health Policy. 2017, 16 (1): 5-14. |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Wu O., Cheung B.M.Y. and Wong C.K.H., OP30 Health Technology Assessment And The Decision-Making Process Of New Drug Listing In Hong Kong, International Journal of Technology Assessment in Health Care. 2018, 33 (S1): 14. |
| Researcher : Cheung CL |
| Project Title: | Genetics and genomics of anti-thyroid drug induced agranulocytosis |
| Investigator(s): | Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study |
| Investigator(s): | Cheung CL, Tan KCB, Kung AWC, Cheung BMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2015 |
| Project Title: | Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study |
| Investigator(s): | Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Metabolomic Study of Osteoporosis in Southern Chinese |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2016 |
| Project Title: | Identification of susceptibility genes involved in the pathogenesis and prediction of thyrotoxic periodic paralysis |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2017 |
| Project Title: | Genetic screening service of HLA-B*38:02 in people prescribing antithyroid drug |
| Investigator(s): | Cheung CL, Tan KCB, Cheung BMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2017 |
| Project Title: | GREM2: A novel blood-based biomarker for osteoporosis and metabolic syndrome? |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2017 |
| Completion Date: | 11/2017 |
| Project Title: | American Society of Bone and Mineral Research ASBMR 2017 Annual Meeting; Glycemic traits are related to phosphate metabolism: A double-edged sword |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| Project Title: | AKAP11 as a positive regulator of osteogenesis |
| Investigator(s): | Cheung CL, Lu WW, Tan KCB |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2018 |
| Project Title: | A comprehensive program for evaluation of musculoskeletal health and pharmacist medication review |
| Investigator(s): | Cheung CL, Chu KPJ |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Beat Drugs Fund Association |
| Start Date: | 05/2018 |
| Researcher : Cheung CYS |
| List of Research Outputs |
| Cheung C.Y.S., Ma K.M.M., Chak W.L. and Tang S.C.W., Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong, Medicine (Baltimore). 2017, 96(38): e8077. |
| Cheung C.Y.S., Ma K.M.M., Chak W.L., Chau K.F. and Tang S.C.W., Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. , Oncotarget. 2017, 8(27): 44833-44841. |
| Researcher : Cheung KF |
| List of Research Outputs |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Yung S.S.Y., Chu J.Y.S., Chau K.M., Cheung K.F. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Human Peritoneal Mesothelial Cells, UK Kidney Week 2017. |
| Researcher : Cheung KS |
| List of Research Outputs |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis, World Journal of Gastroenterology. 2017, 23: 7863-7874. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, Alimentary Pharmacology & Therapeutics. 2018, 47: 43-54. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection, Clinical and Translational Gastroenterology. 2018, 9: 163. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak S.K., Chiu W.H.K., Vardhanabhuti V., Wong H.F., Leong H.T., Lee P., Ho Y.C., Lee C.K., Cheung K.S., Yuen R.M.F. and Leung W.K., Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users, Journal of Hepatology. 2018. |
| Researcher : Cheung KSM |
| List of Research Outputs |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Cheung K.S.M., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016, World Journal of Gastroenterology. 2017, 23: 7716-7726. |
| Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018. |
| Cheung K.S.M. and Leung W.K., Risk of gastric cancer development after eradication of Helicobacter pylori, World Journal of Gastrointestinal Oncology. 2018, 10: 115-123. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75. |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Leung W.K., Wong O.L., Chan E.W., Wong A., Yeung K.F., Chen L., Wong I. and Cheung K.S.M., Top Abstract Award, 25th United European Gastroenterology Week, Barcelona, Spain , United European Gastroenterology. 2017. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Researcher : Cheung RTF |
| Project Title: | Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice |
| Investigator(s): | Cheung RTF |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats |
| Investigator(s): | Cheung RTF |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| List of Research Outputs |
| Cheung R.T.F., Editorial Board, Asian Journal of Neuroscience. Hindawi Publishing, 2018. |
| Cheung R.T.F., Editorial Board, Austin Journal of Anatomy. Austin Publishing Group, 2017. |
| Cheung R.T.F., Editorial Board, Austin Journal of Cerebrovascular Disease & Stroke. Austin Publishing Group, 2018. |
| Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2018. |
| Cheung R.T.F., Editorial Board, Edorium Journal of Neurology. Edorium Journal, 2018. |
| Cheung R.T.F., Editorial Board, JSM Ophthalmology. JSciMedCentral, 2018. |
| Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2018. |
| Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2018. |
| Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2018. |
| Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2018. |
| Cheung R.T.F., Editorial Board, World Journal of Biological Chemistry. Baishideng Publishing Group, 2018. |
| Cheung R.T.F., Journal editor, SM Journal of Neurology and Neuroscience. SM Group, 2018. |
| Cheung R.T.F., Regional Editor, Cardiovascular & Hematological Agents in Medicinal Chemistry. Bentham Science Publishers, 2017. |
| GAO Y., Cheung R.T.F., Gao J., Lau Y.Y.E., WAN H.Y. and Mok M.Y.T., Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement, Clinical EEG and Neuroscience. 2017, 48: 251-258. |
| Guo C.C.T., Chen D.J.Z., Wei I.Y., So R.H.Y. and Cheung R.T.F., Correlations between individual susceptibility to visually induced motion sickness and decaying time constant of after-nystagmus, Applied Ergonomics. 2017, 63: 1-8. |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Cognitive impairments in chronic temporal lobe epilepsy patients: an event-related potential study of prospective memory, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 60. |
| Researcher : Cheung TT |
| Project Title: | Cost of illness of Ankylosing Spondylitis in Hong Kong |
| Investigator(s): | Cheung TT, Lau WCS, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Correlation of Fibroblast Growth Factor 21 (FGF21) with paracetamol levels in patients with paracetamol poisoning |
| Investigator(s): | Cheung TT, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Relationship between drug levels of tutor necrosis factor inhibitors and the clinical and radiological response in patients with axial spondyloarthritis |
| Investigator(s): | Cheung TT, Cheung BMY, Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2016 |
| Project Title: | Provision of Free Herpes Zoster Vaccine for Patients with Inflammatory Arthritis Requiring Biologic Therapies |
| Investigator(s): | Cheung TT, Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2017 |
| List of Research Outputs |
| Cheung B.M.Y. and Cheung T.T., No lead is better than a little lead, Postgraduate Medical Journal. 2017, 93: 512-512. |
| Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J., Li W., Zhao X.M., Wang Z. and Mu S., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants, Clinical Therapeutics. 2018, 40: 719-732.e1. |
| Cheung T.T., Associate Editor, International Journal of Rheumatic Diseases. 2018. |
| Cheung T.T., Best Abstract in Clinical Medicine, 23rd Medical Research Conference, Department of Medicine, University of Hong Kong. 2018. |
| Cheung T.T., Biosimilars in the real world: Where are we now?, China Rheumatology Association Annual Meeting. 2018. |
| Cheung T.T., Can you treat SLE when you can't see or recognise a target?, 5th World Congress on Controversies, Debates and Consensus in Bone, Muscle and Joint Diseases. 2017. |
| Cheung T.T., Consulting Editor, Clinical Therapeutics. 2017. |
| Cheung T.T., How to assess and manage psoriatic arthritis, Hong Kong Beijing Chifeng Medical Forum 2017. 2017. |
| FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs, International Journal of Cardiology. 2018, 254: 291-296. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Researcher : Cheung YY |
| Project Title: | Impact of genetic variants identified in genome-wide association studies and their possible interaction with hypertension on the risk of diabetic retinopathy |
| Investigator(s): | Cheung YY, Lam KSL, Sham PC, Wong DSH, Gangwani RA, Yuen MAM |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Project Title: | 53rd European Association for the Study of Diabetes (EASD) Annual Meeting; Exome-Chip association analyses for diabetic nephropathy and estimated glomerular filtration rate in Chinese patients with type 2 diabetes |
| Investigator(s): | Cheung YY |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| Project Title: | A pilot study of circulating microRNAs as potential biomarkers for the development of sight-threatening diabetic retinopathy in Chinese patients with type 2 diabetes |
| Investigator(s): | Cheung YY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lu X., Peloso G.M., Liu D.J., Wu Y., Zhang H., Zhou W., Li J., Tang S.M., Dorajoo R., LI H., Long J., Guo X., Xu M., Spracklen C.N., Chen Y., Liu X., Zhang Y., Khor C.C., Liu J., Sun L., Wang L., Gao Y., Hu Y., Yu K., Wang Y., Cheung Y.Y., Wang F., Huang J., Fan Q., Cai Q., Chen S., Shi J., Yang X., Zhao W., Sheu W.H., Cherny S.S., He M., Feranil A.B., Adair L.S., Gordon-Larsen P., Du S., Du R., Chen Y.I., Shu X., Lam K.S.L., Wong T.Y., Ganesh S.K., Mo Z., Hveem K., Fritsche L.G., Nielsen J.B., Tse H.F., Huo Y., Cheng C., Chen Y.E., Zheng W., Tai E.S., Gao W., Lin X., Huang W., Abecasis G., Kathiresan S., Mohlke K.L., Wu T., Sham P.C., Gu D. and Willer C.J., Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease, Nature Genetics. 2017, 49: 1722-1730. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Researcher : Chim JCS |
| Project Title: | FISH study and the use of bortezomib in high-risk multiple myeloma |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | Lee Hysan Foundation - General Award |
| Start Date: | 07/2008 |
| Project Title: | Genetic study (FISH study) for personalized treatment of multiple myeloma |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2012 |
| Project Title: | Use of Bortezomib during conditioning of autologous stem cell transplantation of international stage III myeloma |
| Investigator(s): | Chim JCS, Kwong YL, Lie AKW |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2014 |
| Project Title: | Mechanism study of the effect of microenviroment on RANKL expression in myeloma cells |
| Investigator(s): | Chim JCS, Wong KY |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | Identification of methylated miRNAs in acute promyelocytic leukaemia and their potential clinical application |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Project Title: | Application of two cycles of Bortezomib as Consolidation after autologous stem cell transplantation in multiple myeloma |
| Investigator(s): | Chim JCS, Tse EWC, Wong HYH |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2017 |
| Project Title: | Minimal Residual Disease in Multiple Myeloma |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Blood Cancer Foundation - General Award |
| Start Date: | 06/2017 |
| Project Title: | Clinical outcomes of patients with relapsed/refractory multiple myeloma - the real-life experience in Hong Kong |
| Investigator(s): | Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | Takeda Pharmaceuticals (HK) Ltd |
| Start Date: | 03/2018 |
| Researcher : Chiu JWY |
| Project Title: | A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT) |
| Investigator(s): | Chiu WYJ, Yau TCC, Cheung TT |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Chiu KCP |
| List of Research Outputs |
| Ho R.T.H., Fong T.C.T., Hon T., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., An examination of the psychometric properties of Fuld Object Memory Evaluation in assessing episodic memory and retrieval in Chinese elderly, 39th Annual Meeting & Scientific Sessions. New Orleans, Louisiana, Society of Behavioral Medicine, 2018. |
| Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan S.K.J., Chiu K.C.P. and Lam L.C.W., Effects of Dance Movement Intervention on Elderly with Early Dementia: A Preliminary Randomized Controlled Trial, 21st IAGG World Congress of Gerontology and Geriatrics. San Francisco, California, The Gerontological Society of America, 2017. |
| Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Effects of Dance Movement Intervention on Elderly with Early Dementia: Preliminary Results of a Randomized Controlled Trial, 39th Annual Meeting & Scientific Sessions. New Orleans, Louisiana, Society of Behavioral Medicine, 2018. |
| Ho R.T.H., Fong T.C.T., Hon T., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments, Aging & Mental Health. Routledge, 2018, 1-7. |
| Researcher : Chiu WYJ |
| Project Title: | A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT) |
| Investigator(s): | Chiu WYJ, Yau TCC, Cheung TT |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J., Li W., Zhao X.M., Wang Z. and Mu S., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants, Clinical Therapeutics. 2018, 40: 719-732.e1. |
| Chiu W.Y.J., Advance in immunotherapy for renal cell carcinoma, Invited lecture by BMS, Macau, 21st Jun 2018 , 2018. |
| Chiu W.Y.J., Local experience of CDK4/6 inhibitor & management of AI-induced osteoporosis, Invited talk by Breast Cancer Foundation, Annual Scientific Meeting, 26th June 2018, 2018. |
| Chiu W.Y.J., Management of immune related adverse events, Immuno-Oncology Forum, Korea (Sponsored by BMS), 28th October 2017. 2017. |
| Chiu W.Y.J., Palbociclib works in Asians with HR+/HER2- metastatic breast cancer, Ibrance Launch Symposium (Sponsored by Pfizer), Taiwan, 5th August 2017. 2017. |
| Chiu W.Y.J., Leung R., Hze H., Teo P., Choi P., Yau T.C.C., Cheng P., Cheung F.Y. and Cheung P., Real world data on use of palbociclib in hormone-receptor positive HER2 negative metastatic breast cancer among Asian patients, European Society for Medical Oncology Asia (ESMO ASIA) 2017 Congress (17-19 November 2017). 2017. |
| Chiu W.Y.J., The changing landscape of treatment for RCC, Immuno-Oncology Forum, Korea (Sponsored by BMS), 28th October 2017. 2017. |
| Chiu W.Y.J., Treatment advances in ER+ HER2- metastatic breast cancer: real world experiences from Hong Kong, Hospital lecture of Taipei Medical University Hospital, Taipei, 4th August 2017. 2017. |
| Chiu W.Y.J., Updates on Hormone Positive HER2 Negative Advanced Breast Cancer, Best of SABCS, Invited lecture by Breast Oncology Group, 13th Jan 2018, 2018. |
| Iwata H., Masuda N., Kim S.-.B., Inoue K., Rai T.Y., Fujita T.C.C., Shen Z.-.Z., Chiu W.Y.J., Ohtani S. and Takahashi M., Neratinib in the extended adjuvant treatment of patients from Asia with early-stage HER2+ breast cancer after trastuzumab-based therapy: exploratory analyses from the phase III ExteNET trial, San Antonio Breast Cancer Congress (SABCS) 2017, 5-9 December 2017. |
| Lam K.O., Lee K.C., Chiu W.Y.J., Lee V.H.F., Leung R.C.Y., Choy T.S. and Yau T.C.C., The Real World Use of Regorafenib for Metastatic Colorectal Cancer: Multicenter Analysis of Treatment Pattern and Outcomes in Hong Kong, Postgraduate Medical Journal. 2017, 395-400. |
| Yap Y.S., Ito Y., Bornstein O., Han Y., Samant T.S., Liu X. and Chiu W.Y.J., Phase Ib study of ribociclib plus letrozole in a subset of Asian patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer , (ESMO ASIA) 2017 Congress (17-19 November 2017). 2017. |
| Researcher : Chong CK |
| List of Research Outputs |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Researcher : Chong WC |
| List of Research Outputs |
| Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Exosomal microRNA-486-3p mediates acquired resistance to anaplastic lymphoma kinase inhibitor in EML4-ALK translocated lung adenocarcinoma, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 33. |
| Researcher : Chow WS |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Researcher : Choy CBY |
| List of Research Outputs |
| Kwan P.Y.L., Mok M.Y., Choy C.B.Y. and Chan D.T.M., Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet, Nephrology. 2017, 22(10): 821-822. |
| Researcher : Chu HS |
| List of Research Outputs |
| Chu H.S., Yao C.K. and Tan V.P.Y., Food Therapy in Sinosphere Asia, Journal of Clinical Gastroenterology. 2017, 28: EPub. |
| Tan V.P.Y., Chu H.S., Yao C.K. and Gibson P.R., Lactulose, Lactose and Fructose Ingestion Induces Specific Patterns of Gastrointestinal Symptoms in Chinese Subjects with Functional Dyspepsia and Irritable Bowel Symptoms., United Gastroenterology Week. 2017. |
| Yao C.K., Chu H.S. and Tan V.P.Y., Hydrogen Breath Testing In East And Southeast Asia, Journal of Clinical Gastroenterology. 2017. |
| Researcher : Chu JYS |
| List of Research Outputs |
| Yung S.S.Y., Chu J.Y.S., Chau K.M., Cheung K.F. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Human Peritoneal Mesothelial Cells, UK Kidney Week 2017. |
| Researcher : Chu LW |
| Project Title: | A dementia outreach programme in Central, Western and Southern districts of Hong Kong |
| Investigator(s): | Chu LW, Lam KSL, Lee WHP |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 09/2003 |
| List of Research Outputs |
| Chiu P.W., ZHANG H., Wong W.H.S., Liu T., Wong G.H.Y., Lum T.Y.S., Chu L.W. and Mak H.K.F., Anterior Cingulate Cortex Exhibits Age-Related Metabolic Changes Correlation with Behavioral Performance in Attention Task, Alzheimer’s Association International Conference 2017, London, United Kingdom. 2017. |
| Chiu P.W., ZHANG H., Wong W.H.S., Liu T., Wong G.H.Y., Lum T.Y.S., Chu L.W. and Mak H.K.F., Involvement of Glutamate As Mediator in the Bold Change in Attention Control in Healthy Adults Combined TaskBased fMRI and 1H-MRS, Alzheimer’s Association International Conference 2017, London, United Kingdom. 2017. |
| Researcher : Chung ACK |
| Project Title: | Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells |
| Investigator(s): | Chung ACK, Lan HY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2008 |
| Researcher : Chung HY |
| Project Title: | Quantitative assessment of the Spondyloarthitis (SpA) severity by using Diffusion Weighted Imaging (DWI) in 3T magnetic resonance imaging |
| Investigator(s): | Chung HY |
| Department: | Medicine |
| Source(s) of Funding: | Novartis Pharmaceuticals (HK) Ltd |
| Start Date: | 12/2017 |
| Project Title: | To assess the relationship between serum Dickkopf-1 and sclerostin levels with disease activity in patients with axial spondyloarthritis |
| Investigator(s): | Chung HY, Tsang HLH, Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 03/2018 |
| List of Research Outputs |
| Chung H.Y., Anterior thoracic fatty corner lesions are useful in axial spondyloarthritis (SpA) diagnosis --- data from a multicenter back pain-MRI cohort in Hong Kong, The European League Against Rheumatism (EULAR) 2018. |
| Chung H.Y., Arthritis is a common, often overlooked, manifestation of IBD. IBD newsletter., 2018. |
| Chung H.Y., Clinical usefulness of Short Tau Inversion Recovery (STIR) sequence and Diffusion Weighted Imaging (DWI) in Axial Spondyloarthritis (SpA) patients, Japan Colleague of Rheumatology (JCR) International School 2017, 2017. |
| Chung H.Y., Editor, International Journal of Rheumatic Diseases. John Wiley & Sons Australia, Ltd, 2018. |
| Li P.H., Watts T.J., Lui M.S., Lau W.C.S. and Chung H.Y., Recall Urticaria in Adalimumab Hypersensitivity, J Allergy Clin Immunol Pract. 2017, 2017 Nov 22. |
| Tsang H.L.H. and Chung H.Y., The Discriminative Values of the Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Spondyloarthritis-Related Axial Arthritis, JCR: Journal of Clinical Rheumatology. 2017, 23: 267-272. |
| Researcher : Esteban MA |
| List of Research Outputs |
| Zhuang Q., Li W., Benda C., Huang Z., Ahmed T., Liu P., Guo X., Ibanez D.P., Luo Z., Zhang M., Abdul M.M., Yang Z., Yang J., Huang Y., Zhang H., Huang D., Zhou J., Zhong X., Zhu X., Fu X., Fan W., Liu Y., Xu Y., Ward C., Khan M.J., Kanwal S., Mirza B., Tortorella M.D., Tse H.F., Chen J., Qin B., Bao X., Gao S., Hutchins A.P. and Esteban M.A., Publisher Correction: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming., Nat Cell Biol. 2018. |
| Researcher : FEI Y |
| List of Research Outputs |
| FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs, International Journal of Cardiology. 2018, 254: 291-296. |
| Researcher : FU SN |
| List of Research Outputs |
| Dao M.C., FU S.N., Chan C.Y., Wong C.K.H., Wong Y.S., Luk W. and Yiu Y.K., Can Mobile Phone Short Message Service Reminders Improve the Attendance Rate of Multidisciplinary Diabetes Services in a Primary Care Clinic?, 2017 Society for Academic Primary Care (SAPC) Annual Scientific Meeting. 2017. |
| Dao M.C., FU S.N., Chan C.W., Wong C.K.H., Wong Y.S., Luk W. and Yiu Y.K., Use of Short Message Service (SMS) Reminders to Improve the Attendance Rate of Diabetes-related Multidisciplinary Services in a General Outpatient Clinic: A Randomized Controlled Trial, 2018 Hospital Authority Convention. 2018. |
| FU S.N., Dao M.C., Luk W., Ho I.S.F., Lam M.C.H., Cheung S.K., Wong C.K.H. and Cheung B.M.Y., Do Patients with Uncontrolled Hypertension Sustain High Quality Self-Blood Pressure Monitoring after an Interactive Workshop, 2017 Society for Academic Primary Care (SAPC) Annual Scientific Meeting. 2017. |
| FU S.N., Dao M.C., Wong C.K.H. and Yu W.C., What are the health-related quality of life SF-6D scores of the smokers with or without respiratory symptoms, and those who have stopped smoking?, 2017 Society for Academic Primary Care (SAPC) Annual Scientific Meeting. 2017. |
| Researcher : Feng Y |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Researcher : Feng Z |
| Project Title: | 30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages |
| Investigator(s): | Feng Z |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Researcher : Fong HY |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Researcher : Fung JYY |
| List of Research Outputs |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015, Clin Transl Gastroenterol. 2017, 8(8): e116. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis, World Journal of Gastroenterology. 2017, 23: 7863-7874. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Cheung K.S.M., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016, World Journal of Gastroenterology. 2017, 23: 7716-7726. |
| Chok K.S.H., Chan A.C.Y., Fung J.Y.Y., Dai W.C., Cheung T.T. and Lo C.M., Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation, Hepatology International. 2017, 11(6): 517-522. |
| Cui T.Y.S., Wong C.L.T., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C., Ng K.K.C. and Lo C.M., Comparable long-term outcomes of living donor liver transplantation after portal flow modulation. , 21st Asian Congress of Surgery. 2017. |
| Fung J.Y.Y., 慢性乙型肝炎肝移植, 9th Guangdong Hong Kong Hepatology Conference. 2017. |
| Fung J.Y.Y., Alcoholic Liver Disease, Asia Pacific Digestive Week (APDW) 2017. 2017. |
| Fung J.Y.Y., Assessment and Management of Potential Liver Transplant Candidates, International Symposium on Hepatology 2017 (HKASLD). 2017. |
| Fung J.Y.Y., HBV in Liver Transplantation - Is This The End Of The Road, Joint International Congress of ILTS, ELITA, and LICAGE (Lisbon, Portugal). 2018. |
| Fung J.Y.Y., Hepatorenal Syndrome, Asia Pacific Digestive Week (APDW) 2017. 2017. |
| Fung J.Y.Y., Immunosuppression Strategies in 2017, The Liver Transplant Symposium 2017 (Singapore). 2017. |
| Fung J.Y.Y., Indications For Transplant and MELD Exceptions, The Liver Transplant Symposium 2017 (Singapore). 2017. |
| Fung J.Y.Y., Liver Transplantation in Hong Kong, Hong Kong College of Physicians Annual Scientific Meeting. 2017. |
| Fung J.Y.Y., Liver Transplantation for Alcoholic Hepatitis: The CON View, American Transplant Congress 2018 (Seattle, USA). 2018. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleos(t)ide analogs alone after liver transplantation in chronic hepatitis B with preexisting rt204 mutation, Transplantation. 2017, 101(10):: 2391-2398. |
| Fung J.Y.Y., Over 20 Years of Liver Transplantation in Hong Kong, State Key Laboratory for Liver Research Symposium 2017. 2017. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Mak K.W., Ng K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Prevalence of graft steatosis after liver transplantation using controlled attenuation parameter measurements: a large cohort study, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 914A. |
| Fung J.Y.Y., Sarcopenia in Liver Transplantation, The Liver Transplant Symposium 2017 (Singapore). 2017. |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Au K.P., Dai W.C. and Lo C.M., Best Abstract Award (Gold) (Abstract title: Model for the prediction of recurrent HCC after liver transplantation in an Asian population), Asian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. 2017. |
| Ma K.W., Chan A.C.Y., She W.H., Chok K.S.H., Cheung T.T., Dai W.C., Fung J.Y.Y. and Lo C.M., Changing paradigm in the surgical management of hepatocellular carcinoma with salvage transplantation, Transplantation Proceedings. 2018, 50(4): 1087-1093. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Dai W.C., Fung J.Y.Y. and Lo C.M., Defining optimal surgical treatment for recurrent hepatocellular carcinoma - a propensity score matched analysis, Liver Transplantation. 2018, Epub ahead of print. |
| Ma K.W., Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., She W.H., Dai W.C. and Lo C.M., Defining optimal surgical treatment for recurrent hepatocellular carcinoma. A propensity score matched analysis (Oral presentation), The 47th World Congress of Surgery, Basel, Switzerland, 13-17 August 2017. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Dai W.C. and Lo C.M., Hepatocholangiocarcinoma / intrahepatic cholangiocarcinoma – are they contraindication or indication for liver transplantation? A propensity score matched analysis (Oral presentation), The 21st Asian Congress of Surgery in conjunction with the 79th Annual Congress of Japan Surgical Association, Tokyo, Japan, 22-23 November 2017. |
| Ma K.W., Chok K.S.H., She W.H., Cheung T.T., Chan A.C.Y., Dai W.C., Fung J.Y.Y. and Lo C.M., Hepatocholangiocarcinoma/intrahepatic cholangiocarcinoma: are they contraindication or indication for liver transplantation? A propensity score-matched analysis, Hepatology International. 2018, 12(2): 167-173. |
| Ma K.W., Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., She W.H., Dai W.C. and Lo C.M., International Society for Digestive Surgery Grassi Prize 2017 (Abstract title: Defining optimal surgical treatment for recurrent hepatocellular carcinoma. A propensity score matched analysis), The 47th World Congress of Surgery, Basel, Switzerland, 13-17 August 2017. 2017. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Au K.P., Dai W.C. and Lo C.M., Model for the prediction of recurrent HCC after liver transplantation in an Asian population (Oral presentation), Asian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Au K.P., Dai W.C. and Lo C.M., Model for the prediction of recurrent HCC after liver transplantation in an Asian population (Oral presentation), The 9th Meeting of 5 Asian Living Donor Liver Transplantation Centers, Kyoto, Japan, 21 October 2017. |
| Ma K.W., Ng K.C.K., Cheung T.T., She W.H., Sin S.L., Wong C.L.T., Dai W.C., Fung J.Y.Y. and Lo C.M., Transplanting resectable hepatocellular carcinoma – a once for all treatment modality: a propensity score matched analysis (Poster), The 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018. |
| Ma K.W., Chok K.S.H., She W.H., Chan A.C.Y., Cheung T.T., Dai W.C., Fung J.Y.Y. and Lo C.M., Validated nomogram for prediction of recurrence in HCC within Milan criteria (Oral presentation), The 27th International Congress of The Transplantation Society, Madrid, Spain, 30 June - 5 July 2018. |
| Maaroufi A., Vince A., Himatt S.M., Mohamed R R., Fung J.Y.Y., Opare-Sem O., Workneh A., Njouom R., Al Ghazzawi I., Abdulla M., Kaliaskarova K.S., ..... ......, Yuen R.M.F. and Razavi-Shearer K., Historical epidemiology of hepatitis C virus in select countries-volume 4, Journal of Viral Hepatitis. 2017, 24 (Suppl 2): 8-24. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Ng K.C.K., Chok K.S.H., Chan A.C.Y., Cheung T.T., Wong C.L.T., Fung J.Y.Y., Yuen J., Poon R.T.P., Fan S.T. and Lo C.M., Randomized clinical trial of hepatic resection versus radiofrequency ablation for early-stage hepatocellular carcinoma, British Journal of Surgery. 2017, 104(13): 1775-1784. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Wong C.L.T., Cui T.Y.S., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C., Ng K.K.C. and Lo C.M., Excellent outcomes after portal flow modulation in living donor liver transplantation. , 2018 Joint International Congress of ILTS, ELITA & LICAGE. 2018. |
| Wong D.K.H., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Occult hepatitis B infection in hepatocellular carcinoma patients with negative HBsAg, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S474. |
| Yeo Y.H., Ho H.J., Yang H.I., Tseng T.C., Kwak M.S., Park Y.M., Fung J.Y.Y., Buti M., Rodriguez M., Treeprasertsuk S., Preda C.M., Ungtrakul T., Charatcharoenwitthaya P., Li X.Y., Le M.H., Wei B., Zou B.Y., Le A.K., Jeong D., Chien N., Kam L., Hosakh T., Rivetro M., Proca D., Suzuki F., Kobayashi M., SSriprayoon T., Chong Y., Tanwandee T., Yuen R.M.F., Lee H.S., Kao J.H., Lok A., Wu C.Y. and Nguyen M.H., Sa1483 - Real-World Rates of Hepatitis B Surface Antigen (HBSAG) Seroclearance in Patients with Chronic Hepatitis B (CHB): A Systematic Review, Conventional Aggregated Data Meta-Analysis (ADMA) and Individual Patient Data Meta-Analysis (IPDMA), Gastroenterology. 2018, 154: S-1128. |
| Researcher : GAO Y |
| List of Research Outputs |
| GAO Y., Cheung R.T.F., Gao J., Lau Y.Y.E., WAN H.Y. and Mok M.Y.T., Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement, Clinical EEG and Neuroscience. 2017, 48: 251-258. |
| Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3. |
| Researcher : GENG L |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| Researcher : Ge M |
| List of Research Outputs |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Comparative analysis of high-fat diet and intermittent hypoxia impacts on C57BL/6N and C57BL/6J mouse strains, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 25. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Differential effects of high fat diet and intermittent hypoxia on C57BL/6N and C57BL/6J mouse strains., American Thoracic Society International Conference, Sam Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A6407. |
| Researcher : Gu Y |
| List of Research Outputs |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| Researcher : HAN L |
| List of Research Outputs |
| HAN L., Genetic Predisposition To Lung Adenocarcinoma Among Never-smoking Chinese With Different Epidermal Growth Receptor Mutation Status, Lung Cancer. 2017. |
| Researcher : HAN S |
| List of Research Outputs |
| ZHANG Z., Zhang Y., Gao F., HAN S., Cheah K.S.E., Tse H.F. and Lian Q., CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects, Molecular Therapy - Nucleic Acids. 2017, 9: 230-241. |
| Researcher : HUANG D |
| List of Research Outputs |
| HUANG D., Wong C.L., Cheng K.W., Chan P.H.M., Yue W.S., Wong C.K., Ho C.W., Wong I.C.K., Chan E.W. and Siu D.C.W., Impact of provision of time in therapeutic range value on anticoagulation management in atrial fibrillation patients on warfarin, Postgraduate Medical Journal. 2018, 94: 207-211. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| HUANG D., Chan P.H.M., She H.L., Wong C.K., Ho C.W., Cheng Y.Y., Chan E.W., Chiang C.E. and Siu D.C.W., Secular trends and etiologies of venous thromboembolism in Chinese from 2004 to 2016, Thrombosis Research. 2018, 166: 80-85. |
| Researcher : Hai SHJJ |
| Project Title: | Effect of a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist on Hypertension-Induced Atrial Remodelling |
| Investigator(s): | Hai SHJJ, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Hai S.H.J.J., Genetic Screening for Survivors of Sudden Cardiac Arrest, APHRS 2016. 2017. |
| Hai S.H.J.J. and Tse H.F., Myths and legends of right ventricular septal pacing, Journal of Cardiovascular Electrophysiology. 2017. |
| Hai S.H.J.J., Un K.C., Wong C.K., Wong K.L., Zhang Z.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Prognostic implications of early monomorphic and non–monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome, Heart Rhythm. 2018, 15: 822-829. |
| Liu F.Z., Liao H.T., Lin W.D., Xue Y.M., Zhan X.Z., Rao F., Deng H., Huang J., Hai S.H.J.J., Tse H.F. and Wu S.L., Predictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients, International Journal of Cardiology. 2018, 258: 103-108. |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Researcher : He BA |
| List of Research Outputs |
| He B.A., Li Ka Shing Prizes, The University of Hong Kong. 2017. |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Lam S.Y., He B.A. and Leung A.Y.H., Treatment of acute myeloid leukemia in the next decade - Towards real-time functional testing and personalized medicine, Blood Rev. 2017. |
| Ma A.C.H., Shi X., He B.A., Guo Y. and Leung A.Y.H., A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation, Methods Mol Biol. 2017, 1633: 193-218. |
| Usman W.M., Pham T.C., Kwok Y.Y., Vu L.T., Ma V., Peng B., Chan Y.S., Wei L., Chin S.M., Azad A., He B.A., Leung A.Y.H., Yang M., Shyh-Chang N., Cho W.C., Shi J. and Le M.T.N., Efficient RNA drug delivery using red blood cell extracellular vesicles, Nat Commun. 2018, 9(1): 2359. |
| Researcher : Ho CTK |
| List of Research Outputs |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Li P.H., Ko K.L., Ho C.T.K., Lau L.L., Tsang R.K.Y., Cheung T.T., Leung W.K. and Lau W.C.S., Immunoglobulin G4–related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem disease, Hong Kong Medical Journal. 2017. |
| Researcher : Ho JCM |
| Project Title: | MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | F Hoffmann-La Roche and Co. Ltd. - General Award |
| Start Date: | 07/2005 |
| Project Title: | A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy |
| Investigator(s): | Ho JCM, Wong KYM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 02/2007 |
| Project Title: | A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 08/2007 |
| Project Title: | The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Lee Wing Tat Fund |
| Start Date: | 08/2007 |
| Project Title: | A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 11/2007 |
| Project Title: | A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 06/2008 |
| Project Title: | A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed) |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 12/2008 |
| Project Title: | In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Lung Foundation Research Grant |
| Start Date: | 02/2009 |
| Project Title: | A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC) |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 04/2009 |
| Project Title: | Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 04/2009 |
| Project Title: | A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens. |
| Investigator(s): | Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 08/2009 |
| Project Title: | Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus |
| Investigator(s): | Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 04/2010 |
| Project Title: | Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus |
| Investigator(s): | Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 04/2010 |
| Project Title: | Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment |
| Investigator(s): | Ho JCM, Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 08/2010 |
| Project Title: | In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer |
| Investigator(s): | Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | The Hong Kong Anti-Cancer Society (HKACS) - General Award |
| Start Date: | 03/2011 |
| Project Title: | A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene |
| Investigator(s): | Ho JCM, Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 04/2011 |
| Project Title: | Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC) |
| Investigator(s): | Ho JCM, Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 05/2011 |
| Project Title: | In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma |
| Investigator(s): | Ho JCM, Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2011 |
| Project Title: | A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM |
| Investigator(s): | Ho JCM, Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 02/2012 |
| Project Title: | In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma |
| Investigator(s): | Ho JCM, Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2015 |
| List of Research Outputs |
| GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018. |
| Han L., Ho J.C.M. and Pang H.M.H., Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth receptor mutation status., lung cancer. 2017. |
| Ho J.C.M., XU S., Cheng P.N. and Lam S.K., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , American Society of Clinical Oncology. 2018. |
| LEUNG L.L., Lam S.K., Li Y.V. and Ho J.C.M., Tumour Growth Suppressive Effect of Arsenic Trioxide in Squamous Cell Lung Carcinoma, Oncology letters. 2017, 14: 3748-3754. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , IASLC 18th World Conference on Lung Cancer. 2017. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models, 23rd Medical Research Conference. 2018, 24: 34. |
| Lam S.K. and Ho J.C.M., Therapeutic Effect of PEGylated Recombinant Human Arginase (BCT-100) on Mesothelioma and Lung Adenocarcinoma in vitro and in vivo, 1st International Symposium on PEGylated Recombinant Human Arginase in Human Cancers and Autoimmunity. 2017. |
| Li J.Y., Ho J.C.M. and Wong K.H., T790M mutant copy number quantified via ddPCR predicts outcome after osimertinib treatment in lung cancer, Oncotarget. 2018, 9(46): 27929-27939. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, 23rd Medical Research Conference. 2018, 2: 59. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, IASLC 18th World Conference on Lung Cancer. 2017. |
| Researcher : Ho SL |
| Project Title: | Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation |
| Investigator(s): | Ho SL, Song Y, Wang Y |
| Department: | Medicine |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 04/2007 |
| Project Title: | Pathophysiological study of synaptic vesicle protein synaptogyrin3 (SYNGR3) in Parkinson’s disease |
| Investigator(s): | Ho SL, Ho WL, Lam CSC |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Lis P., Burel S., Steger M., Mann M., Brown F., Diez F., Tonelli F., Holton J.L., Ho W.L., Ho S.L., Chou M.Y., Polinski N.K., Martinez T.N., Davies P. and Alessi D.R., Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase, Biochemical Journal. PORTLAND PRESS, 2018, 475: 1-22. |
| Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15. |
| Pang S.Y.Y., Teo K.C., Hsu J.S., Chang S.K.R., Li M., Sham P.C. and Ho S.L., The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review, Translational Neurodegeneration. United Kingdom, BioMed Central, 2017, 6: 27. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| Researcher : Ho WL |
| Project Title: | Neurotoxic effects of environmental estrogenic endocrine disruptive compounds on brain dopamine homeostasis |
| Investigator(s): | Ho WL, Ho SL, Leung KMY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Therapeutic effects of brain-penetrable kinase inhibitors to prevent accumulation of pathogenic alpha-synuclein oligomers in Parkinson’s disease Parkinson’s disease |
| Investigator(s): | Ho WL, Ho SL |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Ho W.L., Editorial Board Member, In: Prof. Osman Sinanovic (Editor-in-chief), BAOJ Neurology. 2017. |
| Ho W.L., Editorial Board Member, Scientific Reports. 2017. |
| Lis P., Burel S., Steger M., Mann M., Brown F., Diez F., Tonelli F., Holton J.L., Ho W.L., Ho S.L., Chou M.Y., Polinski N.K., Martinez T.N., Davies P. and Alessi D.R., Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase, Biochemical Journal. PORTLAND PRESS, 2018, 475: 1-22. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Wu K., Yau S., Xu A. and Cheng K., Ablation of the adaptor protein APPL2 in hypothalamic RIP-Cre neurons by promotes beiging of WAT via sympathetic nervous system, 2017 Singapore Symposium on Metabolic Diseases. 2017. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Liu Z., Wu K., Yau S., Xu A. and Cheng K., Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system, EMBO reports. 2018, 19: e44977. |
| Researcher : Hoo RLC |
| Project Title: | The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation |
| Investigator(s): | Hoo RLC, Zhang J |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Adipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity |
| Investigator(s): | Hoo RLC, Xia Z, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of ischemic stroke associating with obesity |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Completion Date: | 03/2018 |
| Project Title: | Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction. |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Completion Date: | 02/2019 |
| Project Title: | The role of lipid chaperone ap2 in regional adipose tissue expandability |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | 53rd EASD Meeting 2017 ; Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity related renal dysfunction |
| Investigator(s): | Hoo RLC |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| Project Title: | The roles of neutrophil elastase (NE) and proteinase 3 (PR3) in the conversion of white to brown adipocytes |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Hoo R.L.C., Pan Y., Shu L., Lam K.S.L. and Xu A., Adipocyte Fatty Acid Binding Protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11-15 Sep 2017, Lisbon. 2017. |
| Researcher : Hu HC |
| Project Title: | A study to validate a symptom severity questionnaire for patents with functional dyspepsia |
| Investigator(s): | Hu HC, Lam CLK |
| Department: | Medicine |
| Source(s) of Funding: | Health Services Research Fund - Full Grants |
| Start Date: | 10/1998 |
| Researcher : Huang FY |
| Project Title: | EMBL Conference Cancer Genomics; Targeted next generation sequencing identifies frequent genetic alterations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma |
| Investigator(s): | Huang FY |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2017 |
| Completion Date: | 11/2017 |
| Researcher : Huang Z |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| Researcher : Hui CK |
| Project Title: | Significance of occult hepatitis B infection in patients undergoing autologous HSCT |
| Investigator(s): | Hui CK, Liang HSR, Lau G, Lie AKW |
| Department: | Medicine |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2006 |
| Researcher : Hui KMC |
| List of Research Outputs |
| Cowling B.J., Chui S.L.C., Lim W.W., Wu P., Hui K.M.C., Peiris J.S.M. and Chan E.W., Use of influenza antivirals in patients hospitalized in Hong Kong, 2000-2015, PLOS ONE. 2018, 13: e0190306. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., American Thoracic Society International Trainee Scholarship Award 2018 & American Thoracic Society-International Society for Respiratory Diseases Travel Award 2018, American Thoracic Society & American Thoracic Society-International Society for Respiratory Diseases, Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diabetes risk in a Chinese cohert. 2018, 197: A7696. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diebetes risk in a Chinese cohert, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A7696. |
| XU P., Lui M.S.M., Lam C.L.D., Ip M.S.M., Fong D.Y.T. and Hui K.M.C., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population., European Respiratory Society International Congress 2017, Milan Italy, Sep 2017, European Respiratory Journal. 2017, 50 (Suppl 61): PA 1185. |
| Researcher : Hui X |
| Project Title: | SIRT1 in perivascular adipose tissues(PVAT) as a mediator of obesity-induced endothelial dysfunction by controlling brown-to-white transition of PVAT: Molecular mechanisms and therapeutic interventions |
| Investigator(s): | Hui X, Vanhoutte PMGR |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Completion Date: | 10/2018 |
| Project Title: | The non-canonical thermoregulatory pathways in uncoupling protein-1 (UCP1) independent manner |
| Investigator(s): | Hui X, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2017 |
| Project Title: | Lactate produced in adipose tissue as a culprit of obesity-related metabolic complications: mechanisms and clinical implications |
| Investigator(s): | Hui X, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2018 |
| Project Title: | The role of Annexin A8 in adipose and systemic metabolism |
| Investigator(s): | Hui X |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| FENG T. and Hui X., Adipose Tissue, Adipose Tissue as an Endocrine Organ. 2018. |
| Nie T., Zhao S., Mao L., Yang Y., Sun W., Lin X., Liu S., Li K., Sun Y., Li P., Zhou Z., Lin S., Hui X., Xu A., Ma C.W., Xu Y., Wang C., Dunbar P.R. and Wu D., The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity , British Journal of Pharmacology. 2018, 175: 1439-1450. |
| Researcher : Hui YLE |
| Project Title: | Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes |
| Investigator(s): | Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 03/2013 |
| Researcher : Hung FNI |
| Project Title: | Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial |
| Investigator(s): | Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure |
| Investigator(s): | Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial |
| Investigator(s): | Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 12/2014 |
| Project Title: | A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness |
| Investigator(s): | Hung FNI, Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Hung F.N.I., Airborne infections: Pulmonary TB, Measles, Varicella Zoster Virus (VZV), Certificate Course in Infectious Diseases and Infection Control for Health Care Professionals on 7 February 2018. 2018. |
| Hung F.N.I., Clinical Medicine Teaching, Executive Training Programme on Hong Kong Higher Education Management for BengBu Medical College in 2018 on 22 January 2018 (HKUSPACE). 2018. |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Hung F.N.I., Improving Health of the Elderly - Advance in Pneumococcal Disease Management & Vaccination from Pediatrics to Adults, 13th International Symposium on Healthy Aging organised by LKS Faculty of Medicine on 10 March 2018. 2018. |
| Hung F.N.I., Interactive Clinical Case Presentation, 22nd Annual Scientific Meeting organized by Hong Kong Society for Infectious Diseases on 17 March 2018 (Co-charing the session). 2018. |
| Hung F.N.I., Moderator of the Moderated e-poster presentation, Asian Pacific Digestive Week 2017 (APDW 2017). 2017. |
| Hung F.N.I., Novel Strategies for Influenza Vaccination , Combined TSV&PIDST, Taiwan Society of Virology and Pediatric Infectious Diseases of Taiwan on 13-14 October 2017. 2017. |
| Hung F.N.I., Plasma Therapy for Severe Influenza, 人感染H7N9禽流感和重症流感專家研討會 on 22 September 2017. 2017. |
| Hung F.N.I., Prevention and Treatment of Influenza Infection, Biannual Health Exhibition by Hong Kong Society of Critical Care Medicine on 15 October 2017. 2017. |
| Hung F.N.I., Tam A., Leong N., Chan J.F.W. and To K.K.W., Seven Years Follow-up of Combined Influenza and 23-valent Pneumococcal Polysaccharide Vaccine in Older Adults, 28th European Congress of Clinical Microbiology and Infectious Diseases, 21-24 April 2018. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Hung F.N.I., 香港2017年夏季流感疫情和防治經驗, Peking Hong Kong Anti-infection Forum (6th PIDMIC) in Bejing, China on 17-18 November 2017. |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| Leong N., Tam A., Chan J.F.W., To K.K.W. and Hung F.N.I., The Characteristics and outcomes of human metapneumovirus infection in hospitalized older adults, 21-24 April 2018, 28th European Society of Clinical Microbiology and Infectious Diseases . 2018. |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| To K.K.W., Yip C.Y., Lai C.Y.W., Wong C.K.H., Ho T.Y., Pang P.K.P., Ng C.K., Leung K.H., Poon W.S.R., Chan K.H., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study, Clinical Microbiology and Infection. 2018. |
| ZHU H. and Hung F.N.I., Administration of mBD4 reduced A (H1N1)09virus replication in obese mice respiratory tract, Medical Research Conference 2018 (Poster presentation). 2018. |
| ZHU H. and Hung F.N.I., Mouse beta-defensin 4 limits A(H1N1)09 influenza virus replication in respiratory tract of senescent mice, Medical Research Conference 2018 (Oral Presentation). 2018. |
| Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966. |
| Researcher : Hung I.F.N. |
| Project Title: | Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial |
| Investigator(s): | Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure |
| Investigator(s): | Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial |
| Investigator(s): | Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 12/2014 |
| Project Title: | A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness |
| Investigator(s): | Hung FNI, Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Researcher : Hung IFN |
| Project Title: | Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial |
| Investigator(s): | Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure |
| Investigator(s): | Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial |
| Investigator(s): | Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 12/2014 |
| Project Title: | A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness |
| Investigator(s): | Hung FNI, Chan KH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Researcher : Hwang YYG |
| List of Research Outputs |
| Hwang Y.Y.G., Au Yeung K.H.R., Lau H.P. and Kwong Y.L., Complete response of age-related Epstein-Barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide, Annals of Hematology. 2018, 97: 363-366. |
| Hwang Y.Y.G., Singh G.H.H., Chan S.Y.T., Leung G.M.K., Cheung C.Y.M. and Kwong Y.L., Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting, Hematology. 2018, 1-6. |
| Hwang Y.Y.G., Khong P.L. and Kwong Y.L., Low-dose nivolumab induced remission in refractory classical Hodgkin lymphoma, Annals of Hematology. 2017, 96: 1219-1220. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Researcher : Ip MSM |
| Project Title: | The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea |
| Investigator(s): | Ip MSM |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 02/1997 |
| Project Title: | The effect of oral appliance (OA) in treatment of obstructive sleep apnoea |
| Investigator(s): | Ip MSM, Peh WCG, Cooke MS |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/1997 |
| Project Title: | Role of adiponectin in obstructive sleep apnoea |
| Investigator(s): | Ip MSM, Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese |
| Investigator(s): | Ip MSM, Lam KSL, Song Y, Sham PC |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2005 |
| List of Research Outputs |
| Benjaifeld A., Valentine K., Ayas N., Eastwood P., Heinzer R., Ip M.S.M., Patel S., Peppard P., Sinha S., Tufik S., Nunez C. and Malhotra A., Global prevalence of obstructive sleep apnea in adults: Estimation using currently available data, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A3962. |
| Fong Y.H., Liang Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Elucidation of epidermal growth factor receptor pathway in cigarette smoke medium-mediated expression of mucin genes and release of IL-8 in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 46. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Comparative analysis of high-fat diet and intermittent hypoxia impacts on C57BL/6N and C57BL/6J mouse strains, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 25. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Differential effects of high fat diet and intermittent hypoxia on C57BL/6N and C57BL/6J mouse strains., American Thoracic Society International Conference, Sam Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A6407. |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| Ip M.S.M., Chairman, AJS McFadzean Distinguished Lecture, "Novel Approaches in Medicine - Where Are We in the 21st Century?" Conference, Hong Kong, Nov 2017. 2017. |
| Ip M.S.M., Chairman, Inaugural David Todd Distinguished Lecture, "Novel Approaches in Medicine - Where Are We in the 21st Century?" Conference, Hong Kong, Nov 2017. 2017. |
| Ip M.S.M., Invited lecture - Advances in sleep disordered breathing and sleep medicine, 2018 Shenzhen Respiratory Society Annual & International Airway Diseases Conference, Shenzhen, China, Jun 2018. 2018. |
| Ip M.S.M., Invited lecture - Celebrating 130 years of medicine in Hong Kong - perspectives from the Department of Medicine at University of Hong Kong, 2017 Hong Kong-Beijing-Chifeng Medical Forum, Inner Mongolia, China, Jul 2017. 2017. |
| Ip M.S.M., Invited lecture - David Todd Distinguished Lecture - To sleep, to breathe, perchange to dream, Hong Kong Medical Forum, May 2018. 2018. |
| Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2018. |
| Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2018. |
| Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2017. |
| Ip M.S.M., Member of Editorial Board, Sleep Medicine Research of Korean Society of Sleep Medicine. 2018. |
| Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Exosomal microRNA-486-3p mediates acquired resistance to anaplastic lymphoma kinase inhibitor in EML4-ALK translocated lung adenocarcinoma, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 33. |
| Lam C.L.D., Kwok H.H., Yu W.C., Ko F.W., Tam C.Y., Lau A.C., Fong D.Y.T. and Ip M.S.M., CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers, In: Cecilia Devoto, BMC Pulmonary Medicine. 2018, 18(1): 47. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Effects of fine particulate matter collected in Hong Kong in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Jouranal. 2018, 24 (Suppl.1): 45. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Mak J.C.W., CUI Y., Liu W.K.K., Liang Y. and Ip M.S.M., Selegiline suppressed cigarette smoke-induced oxidative stress and inflammation via MAO-B inhibition in rat lung, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A4752. |
| Stanojevic S., Graham B.L., Cooper B.G., Thompson B.R., Cater K.W., Francis R.W., Hall G.L. and Ip M.S.M., Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians, European Respiratory Journal. 2017, 50: 1700010. |
| WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-13. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., American Thoracic Society International Trainee Scholarship Award 2018 & American Thoracic Society-International Society for Respiratory Diseases Travel Award 2018, American Thoracic Society & American Thoracic Society-International Society for Respiratory Diseases, Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diabetes risk in a Chinese cohert. 2018, 197: A7696. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diebetes risk in a Chinese cohert, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A7696. |
| XU P., Lui M.S.M., Lam C.L.D., Ip M.S.M., Fong D.Y.T. and Hui K.M.C., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population., European Respiratory Society International Congress 2017, Milan Italy, Sep 2017, European Respiratory Journal. 2017, 50 (Suppl 61): PA 1185. |
| Researcher : Ip TP |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Researcher : Jiang D |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| Researcher : Jin Y |
| Project Title: | Cytogenetic and molecular genetic characterization of esophageal carcinomas |
| Investigator(s): | Jin Y, Kwong YL, Tsao GSW |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 10/2002 |
| Researcher : KWOK HM |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Researcher : Kopaniszen M |
| List of Research Outputs |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Researcher : Kumana CR |
| List of Research Outputs |
| FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs, International Journal of Cardiology. 2018, 254: 291-296. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgrad Med J. 2017, 93 (1101): 373-375. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgraduate Medical Journal. 2017, 93: 373-375. |
| Kumana C.R. and Kwong Y.L., Inventions Geneva - Gold Medal, Salon International Des Inventions Geneva, IEIG (Under The Patronage Of The Swiss Federal Government And Of The State And The City Of Geneva).. 2018. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Researcher : Kung AWC |
| Project Title: | Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women |
| Investigator(s): | Kung AWC, McGhee S |
| Department: | Medicine |
| Source(s) of Funding: | Health and Health Services Research Fund - Full Grants |
| Start Date: | 10/2009 |
| List of Research Outputs |
| Cheung C.L., Tan K.C.B. and Kung A.W.C., Cohort Profile: The Hong Kong Osteoporosis Study and the follow-up study, International Journal of Epidemiology. 2018, 47: 397-398f. |
| Researcher : Kung MHW |
| List of Research Outputs |
| Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15. |
| Researcher : Kwan JSK |
| Project Title: | HKU Overseas Fellowship Awards 2016-17 |
| Investigator(s): | Kwan JSK |
| Department: | Medicine |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 06/2016 |
| Project Title: | Effects of regular physical activity on immunosenescence: the role of autophagy and apoptosis on senescent T-lymphocytes and NK cells |
| Investigator(s): | Kwan JSK, Wong GTC, Tse MA, Tipoe GL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2017 |
| Project Title: | Innovative IT Platform To Enable Remote Group Cognitive Stimulation Therapy For Better Cognition And Well-being In Older Dementia Patients And Their Caregivers: The FaceCog Project |
| Investigator(s): | Kwan JSK, Wong GHY, Hsiao JHW, Mak HKF, Lum TYS, Wong GTC |
| Department: | Medicine |
| Source(s) of Funding: | Midstream Research Programme for Universities (MRP) |
| Start Date: | 03/2018 |
| List of Research Outputs |
| Chen J.Y., Wu Y.H., Wright A., Kwan J.S.K., Leung G.K.K., Tsang J.P.Y. and Lau W.C.S., Moral distress in medical students: what ethical dilemmas did Hong Kong medical students identify in their clinical clerkships?, Chinese University Medical Education Conference (CUMEC) 2018. |
| Ho R.T.H., Fong T.C.T., Hon T., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., An examination of the psychometric properties of Fuld Object Memory Evaluation in assessing episodic memory and retrieval in Chinese elderly, 39th Annual Meeting & Scientific Sessions. New Orleans, Louisiana, Society of Behavioral Medicine, 2018. |
| Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Effects of Dance Movement Intervention on Elderly with Early Dementia: Preliminary Results of a Randomized Controlled Trial, 39th Annual Meeting & Scientific Sessions. New Orleans, Louisiana, Society of Behavioral Medicine, 2018. |
| Ho R.T.H., Fong T.C.T., Hon T., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments, Aging & Mental Health. Routledge, 2018, 1-7. |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Luo H., Lum T.Y.S., Wong G.H.Y., Kwan J.S.K. and Tang Y.M.J., Predicting Adverse Health Outcomes in Nursing Home: A Frailty Measure Using Minimum Data Set 2.0, IAGG 2017. |
| Researcher : Kwan PYL |
| List of Research Outputs |
| Chan G.C.W., Lee C.H.P., Kwan P.Y.L., Yip T.P.S. and Tang S.C.W., Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism, Nephrology. 2017, 22: 572-572. |
| Kwan P.Y.L., Mok M.Y., Choy C.B.Y. and Chan D.T.M., Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet, Nephrology. 2017, 22(10): 821-822. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Researcher : Kwan SC |
| List of Research Outputs |
| Yick L.W., Ma K.F.O., Ng C.L., Kwan S.C. and Chan K.H., Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice, Frontiers in Immunology . 2018, 9: 1438. |
| Researcher : Kwan SKJ |
| Project Title: | HKU Overseas Fellowship Awards 2016-17 |
| Investigator(s): | Kwan JSK |
| Department: | Medicine |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 06/2016 |
| Project Title: | Effects of regular physical activity on immunosenescence: the role of autophagy and apoptosis on senescent T-lymphocytes and NK cells |
| Investigator(s): | Kwan JSK, Wong GTC, Tse MA, Tipoe GL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2017 |
| Project Title: | Innovative IT Platform To Enable Remote Group Cognitive Stimulation Therapy For Better Cognition And Well-being In Older Dementia Patients And Their Caregivers: The FaceCog Project |
| Investigator(s): | Kwan JSK, Wong GHY, Hsiao JHW, Mak HKF, Lum TYS, Wong GTC |
| Department: | Medicine |
| Source(s) of Funding: | Midstream Research Programme for Universities (MRP) |
| Start Date: | 03/2018 |
| List of Research Outputs |
| Ho R.T.H., Fong T.C.T., Hon T., Li B.Y., Chan W.C., Kwan S.K.J., Chiu K.C.P. and Lam L.C.W., Effects of Dance Movement Intervention on Elderly with Early Dementia: A Preliminary Randomized Controlled Trial, 21st IAGG World Congress of Gerontology and Geriatrics. San Francisco, California, The Gerontological Society of America, 2017. |
| Kwan S.K.J., Frontotemporal Degeneration with Motor Neuron Disease (FTD/MND) in Chinese people (PI, $200K), Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron Disease. 2017. |
| Kwan S.K.J., Gender equity, equality and quality of modern health care, Western Pacific Regional Conference 2017 of Medical Women’s International Association (MWIA 2017). 2017. |
| Kwan S.K.J. and Chen J.Y., Medical Professionalism, In: Tan Kathryn, Problem-based Medical Case Management, 2nd edition. . Hong Kong, Hong Kong University Press, 2017. |
| Kwan S.K.J., Tse M.Y.M. and Li L.S.W., Neurological Rehabilitation, Oxford Textbook of Geriatric Medicine (Third Edition). Oxford University Press, 2017. |
| Kwan S.K.J., Chan H., Wong G.H.Y., Leung A.Y.M., Lai C., Leung P., Chau P., Tse M.A., Pang M. and Chan C.L.W., Personalized, Holistic & Intensive Rehabilitation Care for Frailty and Dementia (Steering Group, HKSR, $141M), Hong Kong Jockey Club Charitable Trust. 2017. |
| Lam K., Kwan S.K.J., Kwan W.C., Chong A.M.L., Lai C.K.Y., Lou V.W., Leung A.Y.M., Liu J.Y.W., Bai X.U.E. and Chi I., Factors Associated With the Trend of Physical and Chemical Restraint Use Among Long-Term Care Facility Residents in Hong Kong: Data From an 11-Year Observational Study, Journal of the American Medical Directors Association. 2017. |
| Lau G.K.K., Wong Y.K., Teo K.C., Chang R.S.K., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Kwan S.K.J., Hui S.K. and Mak H.K.F., Long-term prognostic implications of cerebral microbleeds in Chinese with ischaemic stroke, Journal of the American Heart Association. 2017. |
| XU X., Kwan S.K.J., Mak H.K.F., Wong A., Mok C.T.V. and Hui S.K., Altered white matter structural brain network in patients with subjective cognitive decline and mild cognitive impairment, The 34th Annual Scientific Meeting of ESMRMB, Barcelona, Spain. 2017. |
| Researcher : Kwok HH |
| List of Research Outputs |
| Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Exosomal microRNA-486-3p mediates acquired resistance to anaplastic lymphoma kinase inhibitor in EML4-ALK translocated lung adenocarcinoma, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 33. |
| Lam C.L.D., Kwok H.H., Yu W.C., Ko F.W., Tam C.Y., Lau A.C., Fong D.Y.T. and Ip M.S.M., CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers, In: Cecilia Devoto, BMC Pulmonary Medicine. 2018, 18(1): 47. |
| Lui M.S.M., Kwok H.H., Chiang K.Y. and Lam C.L.D., Malignant Pleural Effusion from Lung Cancers with Driver Mutations, In: Shirin Shafazand, Current Pulmonology Reports. 2018, 7: 13-18. |
| Researcher : Kwok HM |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Researcher : Kwong YL |
| Project Title: | Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma |
| Investigator(s): | Kwong YL |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | Molecular basis of arsenic resistance in tumours |
| Investigator(s): | Kwong YL, Tse EWC |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation |
| Investigator(s): | Kwong YL, Liang HSR, Lie AKW, Au WY |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2004 |
| Project Title: | Provision of ibritumomab for the treatment of lymphoma |
| Investigator(s): | Kwong YL, Liu KY |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2008 |
| Project Title: | Provision of oral arsenic trioxide free to patients with cancers |
| Investigator(s): | Kwong YL, Au WY, Chim JCS |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2008 |
| Project Title: | Provision of ibritumomab for the treatment of Iymphoma |
| Investigator(s): | Kwong YL, Liu KY |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 05/2010 |
| Project Title: | Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia |
| Investigator(s): | Kwong YL, Leung AYH, Tse EWC |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2010 |
| Project Title: | Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia |
| Investigator(s): | Kwong YL, Leung AYH, Tse EWC |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 10/2012 |
| Project Title: | Provision of free azacitidine for high-risk patient with myelodysplastic syndrome (MDS) |
| Investigator(s): | Kwong YL, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2014 |
| Project Title: | Plasma DNA as a Platform Technology for Cancer Detection |
| Investigator(s): | Kwong YL |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 12/2016 |
| List of Research Outputs |
| Chan S.Y.T., Li J., Loong F., Khong P.L., Tse E.W.C. and Kwong Y.L., PD1 blockade with low-dose nivolumab in NK/T cell lymphoma failing l-asparaginase: efficacy and safety, Annals of Hematology. 2017. |
| Cheng C.W., LEONG K.W., NG Y.M., Kwong Y.L. and Tse E.W.C., The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27, Journal of Biological Chemistry. 2017, 292: 21431-21441. |
| Hwang Y.Y.G., Au Yeung K.H.R., Lau H.P. and Kwong Y.L., Complete response of age-related Epstein-Barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide, Annals of Hematology. 2018, 97: 363-366. |
| Hwang Y.Y.G., Singh G.H.H., Chan S.Y.T., Leung G.M.K., Cheung C.Y.M. and Kwong Y.L., Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting, Hematology. 2018, 1-6. |
| Hwang Y.Y.G., Khong P.L. and Kwong Y.L., Low-dose nivolumab induced remission in refractory classical Hodgkin lymphoma, Annals of Hematology. 2017, 96: 1219-1220. |
| Kho C.S., Wong H.N., Sin C.F., Leung Y.Y. and Kwong Y.L., Leonine facies due to Sezary syndrome: complete clinical, radiologic, and molecular remission with alemtuzumab, Annals of Hematology. 2017, 96: 2121-2123. |
| Kumana C.R. and Kwong Y.L., Inventions Geneva - Gold Medal, Salon International Des Inventions Geneva, IEIG (Under The Patronage Of The Swiss Federal Government And Of The State And The City Of Geneva).. 2018. |
| Kwong J.H.Y., Leung R.Y.Y., Wong M.L.G., Singh G.H.H. and Kwong Y.L., Primary myelofibrosis presenting in acute promyelocytic transformation, British Journal of Haematology. 2017, 178: 349-349. |
| Kwong Y.L., Lopes D. and Khong P.L., Low-dose pembrolizumab induced remission in patients with refractory classical Hodgkin lymphoma, British Journal of Haematology. 2017, 96(7): 1219-1220. |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Reddy A., Zhang J., Davis N.S., Moffitt A.B., Love C.L., Waldrop A., Leppa S., Pasanen A., Meriranta L., Karjalainen-Lindsberg M.L., Nørgaard P., Pedersen M., Gang A.O., Høgdall E., Heavican T.B., Lone W., iqbal J., Qin Q., Li G., Kim S.Y., Healy J., Richards K.L., Fedoriw Y., Bernal-Mizrachi L., Koff J.L., Staton A.D., Flowers C.R., Paltiel O., Goldschmidt N., Calaminici M., Clear A., Gribben J., Nguyen E., Czader M.B., Ondrejka S.L., Collie A., Hsi E.D., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Choi W.L., Evens A.M., Pilichowska M., Sengar M., Reddy N., Li S., Chadburn A., Gordon L.I., Jaffe E.S., Levy S., Rempel R., Tzeng T., Happ L.E., Dave T., Rajagopalan D., Datta J., dunson D.B. and Dave S.S., Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma, Cell. 2017, 171: 481-494.e15. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017. |
| Singh G.H.H., Leung G.M.K., Seto W.K.W. and Kwong Y.L., Risk of viral reactivation in patients with occult hepatitis B virus infection during ruxolitinib treatment, Annals of Hematology. 2018. |
| Researcher : LEE THJ |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| Researcher : LEONG KW |
| List of Research Outputs |
| Cheng C.W., LEONG K.W., NG Y.M., Kwong Y.L. and Tse E.W.C., The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27, Journal of Biological Chemistry. 2017, 292: 21431-21441. |
| Researcher : LI B |
| List of Research Outputs |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Researcher : LI X |
| List of Research Outputs |
| LI X., Michaeloudes C., Zhang Y., Wiegman C.H., Adcock I.M., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K.F., Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, Journal of Allergy and Clinical Immunology. 2018, 141: 1634-1645. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Researcher : LI Y |
| List of Research Outputs |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Researcher : LIANG X |
| List of Research Outputs |
| Ding Y., Liang X., Zhang Y.L., Yi L., Shum H.C., Chen Q., Chan B.P., Fan H.M., Liu Z.M., Tergaonkar V., Qi Z.Q., Tse H.F. and Lian Q., Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation, Cell Death & Disease. 2018, 9. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : LIAO B |
| List of Research Outputs |
| LIAO B., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein mediates ischemic stroke, Mini-symposium on brain and adipose tissue crosstalk 2017. 2017. |
| Researcher : LIU F |
| List of Research Outputs |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Researcher : Lai CL |
| Project Title: | A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials |
| Investigator(s): | Lai CL, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 01/2003 |
| Project Title: | Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials |
| Investigator(s): | Lai CL, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 10/2003 |
| Project Title: | A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis |
| Investigator(s): | Lai CL, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Idenix Pharmaceuticals, Inc - General Award |
| Start Date: | 01/2004 |
| Project Title: | Outstanding Researcher Award 2003-2004 |
| Investigator(s): | Lai CL |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 07/2004 |
| List of Research Outputs |
| CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338. |
| CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017. |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015, Clin Transl Gastroenterol. 2017, 8(8): e116. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis, World Journal of Gastroenterology. 2017, 23: 7863-7874. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Cheung K.S.M., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016, World Journal of Gastroenterology. 2017, 23: 7716-7726. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleos(t)ide analogs alone after liver transplantation in chronic hepatitis B with preexisting rt204 mutation, Transplantation. 2017, 101(10):: 2391-2398. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Mak K.W., Ng K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Prevalence of graft steatosis after liver transplantation using controlled attenuation parameter measurements: a large cohort study, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 914A. |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Lai C.L., (399) “認識肝炎, 北角西分區委員會健康講座, jointly organized by北角西分區委員會 and 香港乙肝基金會 , at銅鑼灣社區中心三樓禮堂, Hong Kong, January 13. 2018. |
| Lai C.L., An Update on HBV Treatment, University Health Service, The University of Hong Kong, Hong Kong, November 24. 2017. |
| Lai C.L., An Update on HBV Treatment, University Health Service, The University of Hong Kong, Hong Kong, November 24, 2017. 2017. |
| Lai C.L., Case Discussion: An unusual case of hepatitis reactivation, Symposium 2017, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. 2017. |
| Lai C.L., Case Discussion, Symposium 2017, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. 2017. |
| Lai C.L., Chairperson, Thematic session: Hepatitis C: Treatment Strategy, Asian Pacific Digestive Week 2017 (APDW 2017), Hong Kong, September 25. 2017. |
| Lai C.L., Chronic Hepatitis B: HBsAg Seroclearance, cccDNA and Treatment under Trial, JGHF Okuda Lecturership, Asian Pacific Digestive Week 2017 (APDW 2017), Hong Kong, September 24, 2017.. 2017. |
| Lai C.L., Co-chairperson at Symposium II: Chronic Hepatitis C, The 30th Annual Scientific Meeting and International Sympsoium on Hepatology 2017, The Hong Kong Association for the Study of Liver Diseases, November 5, 2017. 2017. |
| Lai C.L., Co-chairperson, Young Investigators Forum, Novel Approaches in Medicine - Where Are We in the 21st Century?, 130th Anniversary Frontiers Conference Series, jointly organized by Department of Medicine, The University of Hong Kong & The Lancet, Hong Kong, November 18-19. 2017. |
| Lai C.L., Co-chairperson, Young Investigators Forum, Novel Approaches in Medicine - Where Are We in the 21st Century?, The 130th Anniversary Frontiers Conference Series, jointly organized by Department of Medicine, The University of Hong Kong & The Lancet, Hong Kong, November 18-19, 2017. 2017. |
| Lai C.L., Co-chairperson, Symposium II: Chronic Hepatitis C, 30th Annual Scientific Meeting and International Sympsoium on Hepatology 2017, The Hong Kong Association for the Study of Liver Diseases, November 5. 2017. |
| Lai C.L., Discussant, Roundtable Discussion: Toward a Hepatitis Free Hong Kong, ZeShan Foundation in partnership with the the CUHK Centre for Liver Health, Bank of East Asia Harbour View Centre, Hong Kong, March 22, 2018. 2018. |
| Lai C.L., Hepatitis, Health Seminar for Fire Services Department, NT Command Headquarters, at the Auditorium of Ma On Shan Paramedic Training Centre, Hong Kong, January 20. 2018. |
| Lai C.L., Hepatitis, Health Seminar for Fire Services Department, NT Command Headquarters, at the Auditorium of Ma On Shan Paramedic Training Centre, Hong Kong, January 20, 2018. 2018. |
| Lai C.L., Okuda Lectureship on "Chronic Hepatitis B: HBsAg Seroclearance, cccDNA and Treatment Under Trial" at the Asian Pacific Digestive Week 2017, 24 September 2017, Hong Kong, Journal of Gastroenterology and Hepatology Foundation. 2017. |
| Lai C.L., Pan Genotypic Approach to HCV Cure, Gilead APDW Scientific Symposium, Asian Pacific Digestive Week 2017 (APDW 2017), Hong Kong, September 25, 2017. 2017. |
| Lai C.L., Practical Guidelines for the Treatment of Patients with Chronic Hepatitis B (CHB) on Immunosuppression, IL-17 Summit, Greater Bay Area Psoriasis Treatment Summit 2018, Macau, April 28-29. 2018. |
| Lai C.L., Practical Guidelines for the Treatment of Patients with Chronic Hepatitis B (CHB) on Immunosuppression, IL-17 Summit, Greater Bay Area Psoriasis Treatment Summit 2018, Macau, April 28-29, 2018. 2018. |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lai C.L., Update on Chronic Hepatitis C Studies, AbbVie Scientific Meeting, Hong Kong, November 28. 2017. |
| Lai C.L., Update on Chronic Hepatitis C Studies, AbbVie Scientific Meeting, Hong Kong, November 28, 2017. 2017. |
| Lai C.L., Update on Hepatitis B Treatment, Hepatitis B Symposium organized by the Society of Hospital Pharmacists of Hong Kong, 21 July 2017, Hong Kong. 2017. |
| Lai C.L., 認識肝炎, 北角西分區委員會健康講座, jointly organized by北角西分區委員會 and 香港乙肝基金會 , at銅鑼灣社區中心三樓禮堂, Hong Kong, January 13, 2018. 2018. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., An update on the toxicological considerations for protease inhibitors used for hepatitis C infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14(5): 483-491. |
| Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Hepatitis B core protein as a therapeutic target, Expert Opinion on Therapeutic Targets. 2017, 21: 1153-1159. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., Pharmacokinetic evaluation of besifovir for the treatment of HBV infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14: 101-106. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, Alimentary Pharmacology & Therapeutics. 2018, 47: 43-54. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection, Clinical and Translational Gastroenterology. 2018, 9: 163. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Schluep T., Lickliter J., Hamilton J., Lewis D.L., Lai C.L., Lau J.Y.N., Locarnini S.A., Gish R.G. and Given B.D., Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers, Clinical Pharmacology in Drug Development. 2017, 6(4): 350-362. |
| Seto W.K.W., Lai C.L. and Yuen R.M.F., Adefovir dipivoxil, In: Grayson ML, Crowe S, MaCarthy M, Mills J. Mouton J, Paterson DL, Cosgrove SE, Hope W, Kucers' The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs. CRC Press, 2017, 255: 3-15. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Wong D.K.H., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Occult hepatitis B infection in hepatocellular carcinoma patients with negative HBsAg, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S474. |
| Wooddell C.I., Yuen R.M.F., Chan H.L.Y., Gish R.G., Locarnini S.A., Chavez D., Ferrari C., Given B.D., Hamilton J., Kanner S.B., Lai C.L., Lai J.Y.N., Schluep T., Xu Z., Lanford R.E. and Lewis D.L., RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg, Science Translational Medicine. 2017, 9: eaan0241. |
| Younossi Z., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang Y.L., Kao J.H., Kinh N., Lai C.L., Yuen R.M.F., Chan H.L.Y. and Lai W., Sofosbuvir (SOF) and ledipasvir (LDV) combination is associated with high sustained virologic response (SVR) and improvement of health-related quality of life (HRQL) in East Asian patients with hepatitis C virus (HCV) infection, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. 2018, 12 (Suppl 2): S517. |
| Younossi Z.M., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Van K.N., Lai C.L., Yuen R.M.F., Chan H.L.Y. and Lai W., Health-Related Quality of Life (HRQL) in East Asian Patients with Hepatitis C Virus (HCV) Infection: The Impact of Treatment and Sustained Virologic Response (SVR), Hepatology. 2017, 66: 395A-396A. |
| Younossi Z.M., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Nguyen V.A.N. .K., Lai C.L., Yuen R.M.F., Chan H.Y.L. and Lai W., Health-Related Quality of Life (HRQL) in East Asian Patients with Hepatitis C Virus (HCV) Infection: The Impact of Treatment and Sustained Virologic Response (SVR), Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 395A. |
| Yuen R.M.F., Liu S.H.K., Given B., Schluep T., Hamilton J., Lai C.L., Locarnini S., Jackson K., Lai J.Y., Ferrari C. and Gish R.G..., RNA interference therapy with ARC-520 Injection results in long term off-therapy antigen reductions in treatment naïve, HBeAg positive and negative patients with chronic HBV, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S526. |
| Researcher : Lai KN |
| Project Title: | The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN) |
| Investigator(s): | Lai KN, Leung JCK |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2004 |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Lai K.N., Lai A.S. and Tang S.C.W., Viral nephropathies, Scientific American Nephrology, Dialysis and Transplantation, Edited by Ajay K Singh and Leonardo V Riella, Decker Intellectual Properties Inc., . Decker Intellectual Properties Inc., 2017, 2017. |
| Ma M.K., Yap Y.H.D., Li C.L., Mok M.M., Chan G.C., Kwan L.P., Lai K.N. and Tang S.C.W., Enteric coated Mycophenolate Sodium combined with low-dose steroid as first time therapy in minimal change nephrotic syndrome: an open label randomized controlled study, Oncotarget Advance publication . 2018, 2018. |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Lai KWH |
| List of Research Outputs |
| Lai P.L., Lau C.S.T., Wong K.L., Gui H., WANG X., ZHOU T., Lai K.W.H., Tse H.F., Tam P.K.H., Garcia-Barcelo M.M. and Ngan E.S.W., Correction of Hirschsprung-associated mutations in human induced pluripotent stem cells via clustered regularly interspaced short palindromic repeats/Cas9, restores neural crest cell function, Gastroenterology. 2017, 153(1): 139-153. |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017. |
| Researcher : Lam CCS |
| List of Research Outputs |
| Chan Y.H., Lam C.C.S. and Tse H.F., Monozygotic twins with coronary artery ectasia, European Heart Journal - Cardiovascular Imaging. 2018, 19: 471-472. |
| Wong C.K., Chan P.H.M., Lam C.C.S., Kwok O.H., Lam Y.Y. and Siu D.C.W., WATCHMAN device-related thrombus successfully treated with apixaban, Medicine. 2017, 96: e8693. |
| Researcher : Lam CL |
| Project Title: | The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis |
| Investigator(s): | Lam CLD, Ip MSM, Tsao GSW, Lam WK |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2010 |
| Project Title: | Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients |
| Investigator(s): | Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2011 |
| Project Title: | Prospective Evaluation of Selection Criteria for Lung Cancer Screening with Low-dose Thoracic Computed Tomography and Standardized System for Nodule Management - An International Study |
| Investigator(s): | Lam CLD, Lui MSM, Tam CCT, Lam CLK |
| Department: | Medicine |
| Source(s) of Funding: | The Terry Fox Foundation |
| Start Date: | 08/2017 |
| Project Title: | Testing for Plasma EGFR Mutations in Advanced Stage Non-small Cell Lung Cancer |
| Investigator(s): | Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Researcher : Lam CLD |
| Project Title: | The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis |
| Investigator(s): | Lam CLD, Ip MSM, Tsao GSW, Lam WK |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2010 |
| Project Title: | Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients |
| Investigator(s): | Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2011 |
| Project Title: | Prospective Evaluation of Selection Criteria for Lung Cancer Screening with Low-dose Thoracic Computed Tomography and Standardized System for Nodule Management - An International Study |
| Investigator(s): | Lam CLD, Lui MSM, Tam CCT, Lam CLK |
| Department: | Medicine |
| Source(s) of Funding: | The Terry Fox Foundation |
| Start Date: | 08/2017 |
| Project Title: | Testing for Plasma EGFR Mutations in Advanced Stage Non-small Cell Lung Cancer |
| Investigator(s): | Lam CLD |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Chan H.S., Ko F.W.S., Chan J.W., So L.K.Y., Lam C.L.D., Chan V.L., Tam C.Y. and Yu W.C., Comorbidities, mortality, and management of chronic obstructive pulmonary disease patients who required admissions to public hospitals in Hong Kong - computerized data collection and analysis., International Journal of Chronic Obstructive Pulmonary Disease. 2018, 13: 1913. |
| Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Exosomal microRNA-486-3p mediates acquired resistance to anaplastic lymphoma kinase inhibitor in EML4-ALK translocated lung adenocarcinoma, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 33. |
| Lam C.L.D., Kwok H.H., Yu W.C., Ko F.W., Tam C.Y., Lau A.C., Fong D.Y.T. and Ip M.S.M., CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers, In: Cecilia Devoto, BMC Pulmonary Medicine. 2018, 18(1): 47. |
| Lam C.L.D., Deputy Editor, Respirology. 2018. |
| Lui M.S.M., Kwok H.H., Chiang K.Y. and Lam C.L.D., Malignant Pleural Effusion from Lung Cancers with Driver Mutations, In: Shirin Shafazand, Current Pulmonology Reports. 2018, 7: 13-18. |
| Man K.N., Tian Z., Lam C.L.D., Wan J.M.F. and Tan-Un K.C., Satisfaction, preference and error occurrence of three dry powder inhalers as assessed by a cohort naïve to inhaler operation, International Journal of Chronic Obstructive Pulmonary Disease. 2018, 13: 1949. |
| Thomas R., Fysh E.T., Smith N.A., Lee P., Kwan B.C., Yap E., Horwood F.C., Piccolo F., Lam C.L.D., Garske L.A., Shrestha R., Kosky C., Read C.A., Murray K. and Lee Y.C., Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion, JAMA. 2017, 318: 1903. |
| Wu Y.L., Tu H., Feng J., Shi M., Zhao J., Wang Y., Chang J., Wang J., Cheng Y., Zhu J., Tan E.H., Li K., Zhang Y., Lee V.H.F., Yang C.T., Su W.C., Lam C.L.D., Srinivasa B.J., Rajappa S., Ho C.L., Lam K.C., Hu Y., Bondarde S.A., Liu X.Q., Fan J., Kuo D., Wang Y., Pang K. and Zhou C., A Phase IIIb open-label, single-arm study of afatinib in EGFR TKI-naïve patients with EGFRm+ NSCLC: An interim analysis., World Lung Cancer Conference, Yokohama, Japan, 2017. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., American Thoracic Society International Trainee Scholarship Award 2018 & American Thoracic Society-International Society for Respiratory Diseases Travel Award 2018, American Thoracic Society & American Thoracic Society-International Society for Respiratory Diseases, Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diabetes risk in a Chinese cohert. 2018, 197: A7696. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diebetes risk in a Chinese cohert, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A7696. |
| XU P., Lui M.S.M., Lam C.L.D., Ip M.S.M., Fong D.Y.T. and Hui K.M.C., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population., European Respiratory Society International Congress 2017, Milan Italy, Sep 2017, European Respiratory Journal. 2017, 50 (Suppl 61): PA 1185. |
| Researcher : Lam CLK |
| Project Title: | Evaluation Study on Quality of Care of Healthcare Programmes |
| Investigator(s): | Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP |
| Department: | Med - Family Medicine Unit |
| Source(s) of Funding: | Hospital Authority - General Award |
| Start Date: | 04/2010 |
| Project Title: | Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme. |
| Investigator(s): | Lam CLK, Wong W |
| Department: | Med - Family Medicine Unit |
| Source(s) of Funding: | Hospital Authority - General Award |
| Start Date: | 04/2010 |
| Project Title: | Provision of Data Analysis and Report Writing Services for Conducting the Population Health Survey 2014/15 |
| Investigator(s): | Lam CLK, Cheung BMY, Yu YTE, Wong CKH, Guo Y |
| Department: | Family Med & Primary Care |
| Source(s) of Funding: | Department of Health - General Award |
| Start Date: | 07/2016 |
| Project Title: | 10-year risk prediction models of complications and mortality of diabetes mellitus in Chinese patients in primary care in Hong Kong |
| Investigator(s): | Lam CLK, Fong DYT, Tan KCB, Fung SCC, Wan YFE |
| Department: | Family Med & Primary Care |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | NAPCRG 45th Annual Meeting ; Effectiveness of Self-care Enablement Programmes Delivered in Small Groups or by Telephone to Prevent Complications of Diabetes Mellitus |
| Investigator(s): | Lam CLK |
| Department: | Family Med & Primary Care |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2017 |
| Completion Date: | 11/2017 |
| Researcher : Lam KSL |
| Project Title: | The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies |
| Investigator(s): | Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2006 |
| Project Title: | Ageing |
| Investigator(s): | Lam KSL, Xu A, Lum TYS |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 09/2013 |
| Project Title: | Establishing a Phase 1 Clinical Trials Centre in Queen Mary Hospital: Extending Hong Kong's Competitive Edges in Healthcare, Education and Life Sciences Research and Development |
| Investigator(s): | Lam KSL, Lau YL, Cheung BMY, Lam CW, Yau HKC |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Programme on Phase 1 Clinical Trials Centre |
| Start Date: | 02/2014 |
| Project Title: | The Endocrine Society's 100th Annual Meeting & Expo; Circulating Adipocyte Fatty Acid-binding Protein As An Independent Predictor Of Mortality Outcomes In Type 2 Diabetes |
| Investigator(s): | Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2018 |
| Completion Date: | 03/2018 |
| List of Research Outputs |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J., Li W., Zhao X.M., Wang Z. and Mu S., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants, Clinical Therapeutics. 2018, 40: 719-732.e1. |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Hoo R.L.C., Pan Y., Shu L., Lam K.S.L. and Xu A., Adipocyte Fatty Acid Binding Protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11-15 Sep 2017, Lisbon. 2017. |
| LIAO B., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein mediates ischemic stroke, Mini-symposium on brain and adipose tissue crosstalk 2017. 2017. |
| Lam K.S.L., A novel biomarker predictive of clinical outcomes in type 2 diabetes, Xi Jing Diabetes and Endocrine Forum, Xian. 2018. |
| Lam K.S.L., A novel prognostic marker of diabetic complications, Guangdong Hong Kong Macau Bay Area Endocrine Forum, Guangzhou. 2018. |
| Lam K.S.L., Associate Editor, Journal of Diabetes Investigation. 2017. |
| Lam K.S.L., Editorial Board Member, Diabetes Research & Clinical Practice. Elsevier Scientific Publishers, 2018. |
| Lam K.S.L., FGF21, Diabetes & Diabetic Complications: Clinical Perspectives, Diabetes Asia 2017 Conference, Kuala Lumpur. 2017. |
| Lam K.S.L., Non-alcoholic Fatty Liver Disease in Diabetic Patients: Challenges & Opportunities, Diabetes Asia 2017 Conference, Kuala Lumpur. 2017. |
| Lam K.S.L., Strategies to Have Patients More Compliant to Treatment, Diabetes Asia 2017 Conference, Kuala Lumpur. 2017. |
| Lam K.S.L., The new development of T2DM management, AstraZenica Diabetes Summit-Guangzhou. 2018. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| Li R.H.W., Lam K.S.L., Tam S., Wong E., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction Of Metabolically Unhealthy Phenotype By The Visceral Accumulation Index, Lipid Accumulation Index And Triglyceride-glucose Index In Chinese Women With Polycystic Ovary Syndrome, European Society of Human Reproduction and Embryology Annual Meeting, 2-5 Jul 2017, Geneva, Switzerland. 2017. |
| Li R.H.W., Lam K.S.L., Tam S., Wong E.W.K., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction of incident metabolic syndrome and dysglycaemia by adiposity and insulin resistance indices in Chinese women with polycystic ovary syndrome: a 4-year longitudinal study, 100th Annual Meeting & Expo of the Endocrine Society. 2018. |
| Li R.H.W., Lam K.S.L., Tam S., Wong E.W.K., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction of metabolically unhealthy phenotype by the visceral adiposity index, lipid accumulation product and triglyceride-glucose index in Chinese women with polycystic ovary syndrome, 33rd Annual Meeting, European Society of Human Reproduction and Embryology. 2017. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Lu X., Peloso G.M., Liu D.J., Wu Y., Zhang H., Zhou W., Li J., Tang S.M., Dorajoo R., LI H., Long J., Guo X., Xu M., Spracklen C.N., Chen Y., Liu X., Zhang Y., Khor C.C., Liu J., Sun L., Wang L., Gao Y., Hu Y., Yu K., Wang Y., Cheung Y.Y., Wang F., Huang J., Fan Q., Cai Q., Chen S., Shi J., Yang X., Zhao W., Sheu W.H., Cherny S.S., He M., Feranil A.B., Adair L.S., Gordon-Larsen P., Du S., Du R., Chen Y.I., Shu X., Lam K.S.L., Wong T.Y., Ganesh S.K., Mo Z., Hveem K., Fritsche L.G., Nielsen J.B., Tse H.F., Huo Y., Cheng C., Chen Y.E., Zheng W., Tai E.S., Gao W., Lin X., Huang W., Abecasis G., Kathiresan S., Mohlke K.L., Wu T., Sham P.C., Gu D. and Willer C.J., Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease, Nature Genetics. 2017, 49: 1722-1730. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| WU X., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., The Role of Adipocyte Fatty Acid Binding Protein in the Development of Liver Fibrosis, American Diabetes Association 78th Scientific Sessions, 22-26 Jun 2018, Orlando, FL. 2018. |
| Wong H.S., Yeung P.K.K., Lai H.M., Lam K.S.L., Wu W. and Chung S.K., Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas: Three-Dimensional Histology of Pancreas by Tissue Clearing, In: Juan S. Bonifacino, Mary Dasso, Joe B. Harford, Jennifer Lippincott-Schwartz, Kenneth M. Yamada, Current Protocols in Cell Biology. Hoboken, NJ, USA, John Wiley & Sons, Inc., 2017, 77: 19.20.1-19.20.10. |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Researcher : Lam KYI |
| List of Research Outputs |
| Lam K.Y.I., CHOW J.X., Lau W.C.S. and Chan V.S.F., MicroRNA-mediated immune regulation in rheumatic diseases, Cancer Letters. 2018, 431: 201-212. |
| Lam K.Y.I., Chan V.S.F. and Lau W.C.S., Treatment modulation of transcriptional profiles in lupus nephritic patients , 23rd Medical Research Conference. 2018, 24. |
| Researcher : Lam KYJ |
| List of Research Outputs |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219. |
| Tan K.C.B., Shiu S.W.M., Lam K.Y.J., Lee C.H.A. and Wong Y., Serum galectin-3 and all-cause mortality in type 2 diabetes., American Diabetes Association 78th Scientific Sessions, Orlando, USA.. 2018. |
| Researcher : Lam SK |
| Project Title: | Biotech Company in the Faculty of Medicine, The University of Hong Kong |
| Investigator(s): | Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Project Title: | Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system |
| Investigator(s): | Lam SK, Wong CYB, Lin MC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2004 |
| Researcher : Lam SK |
| Project Title: | In Vitro and in vivo combination of arginase and chemotherapeutic drugs in squamous cell lung carcinoma |
| Investigator(s): | Lam SK, Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | The Hong Kong Anti-Cancer Society (HKACS) - General Award |
| Start Date: | 03/2016 |
| Project Title: | Targeting polyamine for prevention and therapy in malignant pleural mesohelioma |
| Investigator(s): | Lam SK, Ho JCM |
| Department: | Medicine |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 12/2016 |
| Project Title: | 18th World Conference of Lung Cancer; Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models |
| Investigator(s): | Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2017 |
| Completion Date: | 10/2017 |
| List of Research Outputs |
| Ho J.C.M., XU S., Cheng P.N. and Lam S.K., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , American Society of Clinical Oncology. 2018. |
| LEUNG L.L., Lam S.K., Li Y.V. and Ho J.C.M., Tumour Growth Suppressive Effect of Arsenic Trioxide in Squamous Cell Lung Carcinoma, Oncology letters. 2017, 14: 3748-3754. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , IASLC 18th World Conference on Lung Cancer. 2017. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models, 23rd Medical Research Conference. 2018, 24: 34. |
| Lam S.K. and Ho J.C.M., Therapeutic Effect of PEGylated Recombinant Human Arginase (BCT-100) on Mesothelioma and Lung Adenocarcinoma in vitro and in vivo, 1st International Symposium on PEGylated Recombinant Human Arginase in Human Cancers and Autoimmunity. 2017. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, 23rd Medical Research Conference. 2018, 2: 59. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, IASLC 18th World Conference on Lung Cancer. 2017. |
| Researcher : Lam SY |
| List of Research Outputs |
| Lam S.Y., He B.A. and Leung A.Y.H., Treatment of acute myeloid leukemia in the next decade - Towards real-time functional testing and personalized medicine, Blood Rev. 2017. |
| Researcher : Lam YF |
| List of Research Outputs |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Researcher : Lan HY |
| Project Title: | Essential role of SMAD3 in cardiac repair and fibrosis |
| Investigator(s): | Lan HY |
| Department: | Medicine |
| Source(s) of Funding: | Sun Chieh Yeh Heart Foundation - General Award |
| Start Date: | 08/2006 |
| Project Title: | Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7 |
| Investigator(s): | Lan HY |
| Department: | Medicine |
| Source(s) of Funding: | Baxter Health Care Ltd. - General Award |
| Start Date: | 05/2008 |
| Project Title: | Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7 |
| Investigator(s): | Lan HY |
| Department: | Medicine |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 05/2008 |
| Researcher : Lan XR |
| Project Title: | Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling |
| Investigator(s): | Lan XR, Lan HY, Leung JCK |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2008 |
| Researcher : Lau CP |
| Project Title: | Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals |
| Investigator(s): | Lau CP, Lee KLF |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 05/2000 |
| Project Title: | Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction |
| Investigator(s): | Lau CP, Yu CM, Lan HY |
| Department: | Medicine |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2000 |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Hai S.H.J.J., Un K.C., Wong C.K., Wong K.L., Zhang Z.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Prognostic implications of early monomorphic and non–monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome, Heart Rhythm. 2018, 15: 822-829. |
| Lau C.P. and Tse H.F., An Unpleasant Legacy, JACC: Clinical Electrophysiology. 2018, 4: 209-211. |
| Lau Y.M., Lo C.H., Lee K.L.F. and Lau C.P., Asystole in focal epilepsy complicating a traumatic subdural hematoma, Journal of Arrhythmia. 2017, 33: 330-332. |
| Murphy A., Banerjee A., Breithardt G., Camm A.J., Commerford P., Freedman B., Gonzalez-Hermosillo J.A., Halperin J.L., Lau C.P., Perel P., Xavier D., Wood D., Jouven X. and Morillo C.A., The World Heart Federation Roadmap for Nonvalvular Atrial Fibrillation, Global Heart. 2017, 12: 273-284. |
| Wong J.A., Conen D., Van Gelder I.C., McIntyre W.F., Crijns H.J., Wang J., Gold M.R., Hohnloser S.H., Lau C.P., Capucci A., Botto G., Grönefeld G., Israel C.W., Connolly S.J. and Healey J.S., Progression of Device-Detected Subclinical Atrial Fibrillation and the Risk of Heart Failure, Journal of the American College of Cardiology. 2018, 71: 2603-2611. |
| Researcher : Lau G |
| Project Title: | Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese |
| Investigator(s): | Lau G |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Liver Foundation - General Award |
| Start Date: | 02/2005 |
| Project Title: | Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection |
| Investigator(s): | Lau G |
| Department: | Medicine |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 12/2007 |
| Researcher : Lau GKK |
| Project Title: | Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese |
| Investigator(s): | Lau G |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Liver Foundation - General Award |
| Start Date: | 02/2005 |
| Project Title: | Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection |
| Investigator(s): | Lau G |
| Department: | Medicine |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 12/2007 |
| Researcher : Lau GKK |
| List of Research Outputs |
| Chan K.H., Lee R., Lau G.K.K. and Loong F., Orbital Ectopic Lymphoid Follicles with Germinal Centers in Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorders, Frontiers in Immunology. 2018, 8: 1947. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Lau G.K.K., Lovelock C.E., Li L., Simoni M., Gutnikov S., Kuker W., Mak H.K.F. and Rothwell P.M., Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review, Stroke. 2018, 49: 1434-1442. |
| Lau G.K.K., Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians. 2017. |
| Lau G.K.K., Ethnic differences and prognostic implications of MRI markers of small vessel disease in patients with cerebrovascular disease, Stroke Seminar, John Radcliffe Hospital, University of Oxford. 2017. |
| Lau G.K.K., Wong Y.K., Teo K.C., Chang R.S.K., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Kwan S.K.J., Hui S.K. and Mak H.K.F., Long-term prognostic implications of cerebral microbleeds in Chinese with ischaemic stroke, Journal of the American Heart Association. 2017. |
| Liu B., Lau G.K.K., Li L., Lovelock C., Liu M., Kuker W. and Rothwell P.M., Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke, Stroke. 2018, STROKEAHA.117.019650. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C.T.V., Chan Q. and Hui S.K., Prognostication of stroke recovery using structural connectivity, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 4821. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C., Mak H.K.F., Chan Q. and Hui S.K., The effect of small vessel disease lesions on structural brain network, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 1907. |
| XU X., Lau G.K.K., Wong Y.K., Mak H.K.F. and Hui S.K., The effect of the total small vessel disease burden on the structural brain network, Scientific Reports. 2018, 8: 7442. |
| Researcher : Lau VYM |
| List of Research Outputs |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Researcher : Lau WCS |
| Project Title: | Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 01/1993 |
| Project Title: | Effects of sex hormones on lymphocyte function in systemic lupus erythematosus |
| Investigator(s): | Lau WCS, Mok MYT |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome |
| Investigator(s): | Lau WCS, Chan YTE, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2005 |
| Project Title: | Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2012 |
| Project Title: | The role of plasmacytoid dendritic cells in systemic lupus erythematosus |
| Investigator(s): | Lau WCS, Chan VSF |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | Advances in Immunology in Health and Disease |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 07/2014 |
| Project Title: | Validation of a new definition of lupus low disease activity state (LLDAS): Clinical and management implications |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Centre for Research into Circulating Fetal Nucleic Acids |
| Investigator(s): | Lau WCS |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Au Y.L.E., Sou Da Rosa Duque J., Lau W.C.S. and Chan Y.T.E., A patient with anaphylaxis to diphenhydramine without cross-reactivity to loratadine, The Journal of Allergy and Clinical Immunology: In Practice. 2018, 6: 1061-1063. |
| Au Y.L.E., Ip W.K., Lau W.C.S. and Chan Y.T.E., Evaluation of a multiplex flow immunoassay versus conventional assays in detecting autoantibodies in systemic lupus erythematosus, Hong Kong Medical Journal. 2018. |
| Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17. |
| Chen D.Y., Lau W.C.S., Elzorkany B., Hsu P.N., Praprotnik S., Vasilescu R., Marshall L. and Llamado L., Dosing down and then discontinuing biologic therapy in rheumatoid arthritis: a review of the literature., International Journal of Rheumatic Diseases. 2017. |
| Chen J.Y., Chin W.Y., Chan L.K., Tiwari A.F.Y., Wong J.Y.H., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Free Paper Presentation - Poster Audience Award, Asian Medical Education Association. 2017. |
| Chen J.Y., Wu Y.H., Wright A., Kwan J.S.K., Leung G.K.K., Tsang J.P.Y. and Lau W.C.S., Moral distress in medical students: what ethical dilemmas did Hong Kong medical students identify in their clinical clerkships?, Chinese University Medical Education Conference (CUMEC) 2018. |
| Chen J.Y., Chin W.Y., Chan L.K., Tsang J.P.Y. and Lau W.C.S., Stress and its effect on learning among first year healthcare professions students in Hong Kong, Hong Kong Mental Health Conference, Hong Kong Academy of Medicine. 2017. |
| Chin W.Y., Chen J.Y., Chan K.H., Wan Y.F., Chan L.K. and Lau W.C.S., Mental And Physical Health Of Early To Mid-career Doctors In Hong Kong: A Cross-sectional Study, Australasian Doctors’ Health Conference . 2017. |
| Chin W.Y., Wan Y.F., Chan K.H., Chen J.Y., Chan L.K. and Lau W.C.S., Merit Award, Asian Medical Education Association (AMEA). 2017. |
| Chin W.Y., Wan Y.F., Chan K.H., Chen J.Y., Chan L.K. and Lau W.C.S., The Longitudinal Outcomes of HKU MBBS Students: A 20-year Retrospective Cohort Review., Asian Medical Education Association (AMEA) Conference 2017. |
| Golder V., Kandane-Rathnayake R., Hoi A.Y., Huq M., Louthrenoo W., An Y., Li Z.G., Luo S.F., Sockalingam Z., Lau W.C.S., Mok M.Y.T., Lateef A., Franklyn K., Morton S., Navarra S.T., Zamora L., Wu Y.J., Hamijoyo L., Chan M., O’Neill S., Goldblatt F., Nikpour M. and Morand E.F., Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study, Arthritis Research & Therapy. 2017, 19. |
| Lam K.Y.I., CHOW J.X., Lau W.C.S. and Chan V.S.F., MicroRNA-mediated immune regulation in rheumatic diseases, Cancer Letters. 2018, 431: 201-212. |
| Lam K.Y.I., Chan V.S.F. and Lau W.C.S., Treatment modulation of transcriptional profiles in lupus nephritic patients , 23rd Medical Research Conference. 2018, 24. |
| Lau W.C.S., APLAR Rheumatoid Arthritis Treatment Recommendations, Pfizer Dinner Symposium, Renaissance Hong Kong Harbour View Hotel, 13 April 2018. 2018. |
| Lau W.C.S., An introduction to the Hong Kong Academy of Medicine. Bangladesh College of Physicians and Surgeons, Dhaka, January 2018, Bangladesh College of Physicians and Surgeons, Dhaka, January 2018. 2018. |
| Lau W.C.S., Gibofsky A., Damjanov N., Lula S., Marshall L., Jones H. and Emery P., Down-titration of biologics for the treatment of rheumatoid arthritis: a systematic literature review, Rheumatology International. 2017. |
| Lau W.C.S., Flipping the Classroom in Medical Education. 2017, SKKU-SOM Internatioal Symposium on Medical Education, Seoul, 8-10 November, 2017. 2017. |
| Lau W.C.S., How to build a culture of reflection in medical training programmes?, 2017 IAMRA Symposium on Continued Competence, London, 3-7 October, 2017. 2017. |
| Lau W.C.S., Introduction on Post Graduate Specialist Training., Career Talk on 2018/19 HA Resident Training Program, Hong Kong Academy of Medicine Jockey Club Building, 20 January 2018. 2018. |
| Lau W.C.S., Introduction to change management., Vietnam Leadership Course, Ho Chi Minh City, June 2018. 2018. |
| Lau W.C.S., Model of University Governance: The University of Hong Kong., Vietnam Leadership Course, Ho Chi Minh City, June 2018. 2018. |
| Lau W.C.S., Novel Therapies for Spondyloarthritis., 香港大学深圳医院五周年庆祝系列学术会议之脊柱关节炎新进展学习班暨第五届港大风湿论坛 (29th July, 2017). 2017. |
| Lau W.C.S., Novel Therapies for Spondyloarthritis., 香港大学深圳医院五周年庆祝系列学术会议之脊柱关节炎新进展学习班暨第五届港大风湿论坛. 香港大学深圳医院 (29th July, 2017). 2017. |
| Lau W.C.S., Obituary: Professor Sir David Todd, Hong Kong Medical Journal. 2017, 541-541. |
| Lau W.C.S., Overview of the Graduate Medical Education in Hong Kong., Summit Forum of Standardized Residencing Training in Zhongzhan Hospital, Fudan University, Shanghai, 8 July, 2017. 2017. |
| Lau W.C.S., Overview of the Graduate Medical Education in Hong Kong, Summit Forum of Standardized Residency Training in Zhongzhan Hospital, Fudan University, Shanghai, 8-9 July, 2017. 2017. |
| Lau W.C.S., Perspectives from Hong Kong: Training the future physicians in the "Training of specialists: are we on the right track" Symposium., 51st Singapore-Malaysia Congress of Medicine (SMCM), Singapore, 20-23 July, 2017. 2017. |
| Lau W.C.S., Perspectives from Hong Kong: Training the future physicians., 51st Malaysia-Singapore Congress of Medicine, Singapore, July 2017. 2017. |
| Lau W.C.S., Recent Progress in the Treatment of Systemic Lupus Erythematosus., 23 Annual Scientific Meeting China Rheumatology Association, Fuzhou, China, 24-25 May 2018. 2018. |
| Lau W.C.S., Revised RA Treatment Recommendation., 22nd Annual International Conference, Pakistan Society for Rheumatology, Lahore, Pakistan, 8 April 2018. 2018. |
| Lau W.C.S., Social Determinants of Health., American College of Physician’s International Medicine Meeting, New Orleans, USA, 18-22 April, 2018. 2018. |
| Lau W.C.S., State of the Art Lecture: Future of Rheumatology in Asia., 22nd Annual International Conference, Pakistan Society for Rheumatology, Lahore, Pakistan, 7 April 2018. 2018. |
| Lau W.C.S., State of the Art Lecture: Revised RA Treatment Recommendation., 22nd Annual International Conference, Pakistan Society for Rheumatology, Lahore, Pakistan, 8 April 2018. 2018. |
| Lau W.C.S., The future of rheumatology in Asia., International Conference of Chinese Rheumatologists (ICCR 2017), Regal Kowloon Hotel, Hong Kong, 18-19 November, 2017. 2017. |
| Lau W.C.S., The role of a leader., Vietnam Leadership Course, Ho Chi Minh City, June 2018. 2018. |
| Lau W.C.S., Training of Medical Specialist in Hong Kong., 中華醫學會件學術年會與第二屆中巴醫學大會暨一帶一路醫學學會論壇, 25-28 January, 2018. 2018. |
| Lau W.C.S., 从亚洲角度看医学教育师资培养., 中山医学教育国际论坛,粤港澳大湾区医学教育论坛,广东省医师协会毕业后医学教育工作委员会年会. Guangzhou, 30 March 2018. 2018. |
| Lau W.C.S., 住院医师能力评价和反馈., Dr Sun Yat Sen Medical University, Guangzhou, 2 December, 2017. 2017. |
| Li P.H., Ko K.L., Ho C.T.K., Lau L.L., Tsang R.K.Y., Cheung T.T., Leung W.K. and Lau W.C.S., Immunoglobulin G4–related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem disease, Hong Kong Medical Journal. 2017. |
| Li P.H., Watts T.J., Lui M.S., Lau W.C.S. and Chung H.Y., Recall Urticaria in Adalimumab Hypersensitivity, J Allergy Clin Immunol Pract. 2017, 2017 Nov 22. |
| Researcher : Lee CHA |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219. |
| Tan K.C.B., Shiu S.W.M., Lam K.Y.J., Lee C.H.A. and Wong Y., Serum galectin-3 and all-cause mortality in type 2 diabetes., American Diabetes Association 78th Scientific Sessions, Orlando, USA.. 2018. |
| Researcher : Lee CHP |
| Project Title: | The Role of Novel Serum Biomarkers and Dietary Pattern in Non-Alcoholic Fatty Liver Disease among Chinese patients with Type 2 Diabetes in Hong Kong |
| Investigator(s): | Lee CHP, Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2016 |
| Project Title: | Adipocyte fatty acid binding protein as a novel marker of the development of sight threatening diabetic retinopathy |
| Investigator(s): | Lee CHP, Lam KSL, Yuen MAM, Wong YHI, Fong HY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| List of Research Outputs |
| Chan G.C.W., Lee C.H.P., Kwan P.Y.L., Yip T.P.S. and Tang S.C.W., Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism, Nephrology. 2017, 22: 572-572. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lee C.H.P., Adipocyte fatty acid binding protein, diabetic complications and mortality, 12th Asia Pacific Diabetes & Obesity Symposium (APDO). 2017. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| Lee C.H.P., New-generation insulin analogue provides glucose control with reduced blood glucose variability and hypoglycaemia risk, MIMS Doctor. 2017. |
| Lee C.H.P., Non-alcoholic Fatty Liver Disease in Diabetes; and Living with Diabetes, Update in Diabetes Management 2017. 2017. |
| Ma A., Mak M.S., Shih K.C., Tsui C.K., Cheung R.K., Lee S.H., Leung H., Leung J.N., Leung J.T., Van-Boswell M.Z., Wong M.T., Ng L.K.A., Lee C.H.P., Jhanji V. and Tong L., Association of long-term glycaemic control on tear break up times and dry eye symptoms in Chinese patients with type 2 diabetes, Clinical & Experimental Ophthalmology. 2018. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Siu M.F.P., Chin E.C., Wong S.H., Fong D.Y.T., Chan D.K.C., Ngai H.H., Lee C.H.P. and Yung P.S., Low-frequency high-intensity interval training (HIIT) improves cardiorespiratory fitness and body composition in overweight adults, Medicine and Science in Sports and Exercise. 2018, 49(5): S169. |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Researcher : Lee CY |
| List of Research Outputs |
| Lee C.Y., Mak H.K.F., Chiu P.W., Chang H.C.C., Barkhof F. and Chan K.H., Differential brainstem atrophy patterns in multiple sclerosis and neuromyelitis optica spectrum disorders, Journal of Magnetic Resonance Imaging. US, Wiley, 2017. |
| Researcher : Lee KLF |
| List of Research Outputs |
| Lau Y.M., Lo C.H., Lee K.L.F. and Lau C.P., Asystole in focal epilepsy complicating a traumatic subdural hematoma, Journal of Arrhythmia. 2017, 33: 330-332. |
| Researcher : Lee P |
| List of Research Outputs |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017. |
| Yap Y.H.D., Tang C.S.O., Lee P., Tam C., Yam I., Yung S.S.Y. and Chan D.T.M., Relationship between B cell signatures and disease flare in lupus nephritis patients, American Society of Nephrology Kidney Week 2017, New Orleans USA. 2017. |
| Researcher : Lee TMC |
| Project Title: | Selective attention biases of people with major depressive disorder, and its relationship with brain damages. |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Cognitive Dysfunction after Anesthesia (CoDA) Study |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Project Title: | Research Output Prize (Faculty of Social Sciences) |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 11/2007 |
| Project Title: | The neural effect of focused-attention meditation and loving-kindness meditation on attention and emotion perception |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Incentive Award for RGC GRF Fundable But Not Funded Projects |
| Start Date: | 07/2011 |
| Project Title: | Outstanding Researcher Award 2010-11 |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2011 |
| Project Title: | Neuroscience |
| Investigator(s): | Lee TMC, Chan YS |
| Department: | Psychology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2013 |
| Project Title: | King's/HKU Fellowship Awards 2014-15 |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 07/2014 |
| Project Title: | Service Model for Promoting Healthy Aging of Sandwich-class Older People |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Fu Tak Iam Foundation Limited |
| Start Date: | 09/2015 |
| Project Title: | The biobehavioral relationships between heart rate variability and anxiety |
| Investigator(s): | Lee TMC, Li XS |
| Department: | Psychology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 09/2018 |
| Project Title: | Preventing return of fear through memory reconsolidation: An investigation of neurocognitive mechanisms using a novel Multi-CS-Conditioning Paradigm. |
| Investigator(s): | Lee TMC |
| Department: | Psychology |
| Source(s) of Funding: | Germany/Hong Kong Joint Research Scheme |
| Start Date: | 01/2018 |
| Project Title: | To investigate the effect of feedback learning on attention |
| Investigator(s): | Lee TMC, Sham PC, Chan JSM |
| Department: | Psychology |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Hu Y., Chen Z., Huang L., Xi Y., Li B., Wang H., Yan J., Lee T.M.C., Tao Q., So K.F. and Ren C., A translational study on looming-evoked defensive response and the underlying subcortical pathway in autism, Scientific Reports. 2017, 7: 14755. |
| Researcher : Lee YK |
| Project Title: | Validation of preclinical molecular diagnosed hypertrophic cardiomyopathy (HCM) using patient specific human induced pluripotent stem cell (hiPSC) platform-new perspectives in personalized drug-screening |
| Investigator(s): | Lee YK |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017. |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Mura M..., Lee Y.K., Ginevrino M., Zappatore R., Dagradi F., Crotti L., Valente E.M., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene., Stem Cell Research . 2018, 29: 157-161. |
| Researcher : Lee YKM |
| List of Research Outputs |
| WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-13. |
| Researcher : Leung AYH |
| Project Title: | Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong |
| Investigator(s): | Leung AYH, Kwong YL |
| Department: | Medicine |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2009 |
| Project Title: | Study of Microglia and Myeloid Leukemia in Zebrafish |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 05/2013 |
| Project Title: | Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2014 |
| Project Title: | Provision of free next generation sequencing (NGS) service of prognostic and therapeutic values for patients with acute myeloid leukemia in Hong Kong |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2016 |
| Project Title: | Establish a zebrafish model to study the molecular and clonal heterogeneity and develop personalized treatment in FLT3-ITD+ AML |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2016 |
| Project Title: | Provision of free decitabine for young patients with acute myeloid leukemia (AML) carrying DNMT3A mutation |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2017 |
| Project Title: | A Comprehensive and Multidisciplinary Approach Targeting Acute Myeloid Leukaemia in Hong Kong (TRS) |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2017 |
| Project Title: | Targeting DNA damage and repair mechanism in FLT3-ITD acute myeloid leukaemia (AML) - a mechanistic and therapeutic study |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Follistatin as a novel target and biomarker for acute myeloid leukaemia (AML) carrying internal tandem duplication (ITD) of Fms-Like Tyrosine kinase 3 (FLT3). |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Develop a high throughput platform for personalized treatment of acute myeloid leukaemia |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Croucher Senior Medical Research Fellowships |
| Start Date: | 01/2018 |
| Project Title: | Provision of Free Azacitidine as Maintenance Therapy for Haematopoietic Stem Cell Transplant Recipients at High Risk of Relapse from Acute Myeloid Leukaemia |
| Investigator(s): | Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Leung A.Y.H., Editor Board Member, BLOOD. 2018. |
| Researcher : Leung CMM |
| List of Research Outputs |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Researcher : Leung JCK |
| Project Title: | Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications |
| Investigator(s): | Leung JCK |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2013 |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Leung KP |
| List of Research Outputs |
| Deng X., Chau L.H.P., Chiu S.Y., Leung K.P., LI S.W. and Ip W.Y., Exploratory use of ultrasound to determine whether demyelination following carpal tunnel syndrome co-exists with axonal degeneration, Neural Regeneration Research. 2018, 13: 317. |
| Researcher : Leung RCY |
| List of Research Outputs |
| Lam K.O., Lee K.C., Chiu W.Y.J., Lee V.H.F., Leung R.C.Y., Choy T.S. and Yau T.C.C., The Real World Use of Regorafenib for Metastatic Colorectal Cancer: Multicenter Analysis of Treatment Pattern and Outcomes in Hong Kong, Postgraduate Medical Journal. 2017, 395-400. |
| Researcher : Leung WK |
| Project Title: | Detection of methylated Septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer |
| Investigator(s): | Leung WK, Shin VY, Law WL |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Completion Date: | 11/2017 |
| Project Title: | Use of Fecal Calprotection for Diagnosis and Monitoring of Patients with Inflammatory Bowel Disease |
| Investigator(s): | Leung WK, Hung FNI, Liu SHK |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2016 |
| Project Title: | European Helicobacter and Microbiota Study Group (EHMSG 2017) ; Long-term proton pump inhibitors and risk of gastric cancer after eradication of H. pylori: A population-based study |
| Investigator(s): | Leung WK |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| Completion Date: | 09/2017 |
| Project Title: | Provision of Small Bowel Capsule Endoscopy and Balloon-Assisted Enteroscopy to Patients with Small Bowel Diseases |
| Investigator(s): | Leung WK, Hung FNI, Wong SY, But YKD, Liu SHK |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2018 |
| List of Research Outputs |
| Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605. |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749. |
| Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018. |
| Cheung K.S.M. and Leung W.K., Risk of gastric cancer development after eradication of Helicobacter pylori, World Journal of Gastrointestinal Oncology. 2018, 10: 115-123. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018. |
| El-Zaatari M., Bass A.J., Bowlby R., Zhang M., Syu L.J., Yang Y., Grasberger H., Shreiner A., Tan B., Bishu S., Leung W.K., Todisco A., Kamada N., Cascalho M., Dlugosz A.A. and Kao J.Y., Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity, Gastroenterology. 2018, 154: 140-153.e17. |
| LAU C.Y., Li X., Wong I.C.K., Man K.C.K., Lip G.Y.H., Leung W.K., Siu D.C.W. and Chan E.W., Bleeding-Related Hospital Admissions and 30-Day Re-Admissions in Patients with Nonvalvular Atrial Fibrillation Treated with Dabigatran versus Warfarin, Journal of Thrombosis and Haemostasis. 2017, 15: 1923-1933. |
| Leung W.K., Best of DDW 2017: HP eradication, Asia Pacific Digestive Week, Hong Kong. 2017. |
| Leung W.K., Biologics; Role and Goal for IBD Treatment, The Annual Meeting of The Gastroenterological Association of Thailand (GAT), Bangkok, Thailand. 2017. |
| Leung W.K., Colon Capsule Endoscopy, National Capsule Endoscopy Academic Conference 2017, Shanghai, China. 2017. |
| Leung W.K., Colon capsule endoscopy, Annual Meeting of the Digestive Endoscopy Society of Taiwan, Taipei. 2017. |
| Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75. |
| Leung W.K., Future directions of capsule endoscopy, Annual Meeting of the Digestive Endoscopy Society of Taiwan, Taipei, 2017 Oct. 2017. |
| Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35. |
| Leung W.K., Optimization of anti-TNFs in IBD, the 6th Cross-strait Digestive Forum and the World Chinese Digestive Summit, Nanjing, China. 2017. |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Leung W.K., RFA in gastric intestinal metaplasia, the 6th Endoscopy RFA Expert Meeting, Inner Mongolia, China. 2017. |
| Leung W.K., Wong O.L., Chan E.W., Wong A., Yeung K.F., Chen L., Wong I. and Cheung K.S.M., Top Abstract Award, 25th United European Gastroenterology Week, Barcelona, Spain , United European Gastroenterology. 2017. |
| Leung W.K., Why screen for colorectal cancer?, Gut 2017, Annual Meeting of the Malaysian Society of Gastroenterology & Hepatology, Penang, Malaysia. 2017. |
| Li J. and Leung W.K., Colon capsule endoscopy for inflammatory bowel disease, Journal of Digestive Diseases. 2018. |
| Li P.H., Ko K.L., Ho C.T.K., Lau L.L., Tsang R.K.Y., Cheung T.T., Leung W.K. and Lau W.C.S., Immunoglobulin G4–related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem disease, Hong Kong Medical Journal. 2017. |
| Seto W.K.W., Mak S.K., Chiu W.H.K., Vardhanabhuti V., Wong H.F., Leong H.T., Lee P., Ho Y.C., Lee C.K., Cheung K.S., Yuen R.M.F. and Leung W.K., Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users, Journal of Hepatology. 2018. |
| So J., Tang W., Leung W.K., Li M., Lo F.H., Wong M.T.L., Sze A.S.F., Leung C.M., Tsang S.W.C., Shan E.H.S., Chan K.H., Lam B.C.Y., Hui A.J., Chow W.H., Lam T.Y., Lam V., Lee T.W., Lo H.H.H., Tang C.M., Wong C.L., Wu J.C.Y., Chan F.K.L., Sung J.J.Y., Harbord M. and Ng S.C., Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease, Inflammatory Bowel Diseases. 2017, 23: 2061-2068. |
| Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017. |
| Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017. |
| Researcher : Li G |
| Project Title: | Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
| Investigator(s): | Li GR, Lau CP, Chiu SW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2001 |
| Researcher : Li GR |
| Project Title: | Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
| Investigator(s): | Li GR, Lau CP, Chiu SW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2001 |
| Researcher : Li J |
| Project Title: | Manipulation of the Gut Microbiota for Metabolic Health; Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota |
| Investigator(s): | Li J |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2018 |
| List of Research Outputs |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Li J., Woo W.H.C. and Xu A., Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota, Keystone Symposia: Manipulation of the Gut Microbiota for Metabolic Health. 2018. |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Li J. and Leung W.K., Colon capsule endoscopy for inflammatory bowel disease, Journal of Digestive Diseases. 2018. |
| Woo W.H.C., Xu A. and Li J., Faculty Research Output Prize, Li Ka Shing Faculty of Medicine, HKU. 2017. |
| YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018. |
| Researcher : Li J |
| List of Research Outputs |
| Hung F.N.I., Li J., To K.K.W., Chan J.F.W., Chan T.C.I., Chan K.H. and Yuen K.Y., High Mortality Associated with Parainfluenza Virus Infection in Hospitalized Adults , ID Week 2017, 4-6 October, 2017 (Poster presentation). 2017, 4: S568. |
| Li J., Woo W.H.C. and Xu A., Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota, Keystone Symposia: Manipulation of the Gut Microbiota for Metabolic Health. 2018. |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| Li J. and Leung W.K., Colon capsule endoscopy for inflammatory bowel disease, Journal of Digestive Diseases. 2018. |
| Woo W.H.C., Xu A. and Li J., Faculty Research Output Prize, Li Ka Shing Faculty of Medicine, HKU. 2017. |
| YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018. |
| Researcher : Li LSW |
| List of Research Outputs |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Kwan S.K.J., Tse M.Y.M. and Li L.S.W., Neurological Rehabilitation, Oxford Textbook of Geriatric Medicine (Third Edition). Oxford University Press, 2017. |
| Li J., Kwan J.S.K., Leung C.M.M., Cheung R.T.F., Ho S.L. and Li L.S.W., Assessment of sympathetic skin response for the diagnosis of post-stroke complex regional pain syndrome, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 40. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C.T.V., Chan Q. and Hui S.K., Prognostication of stroke recovery using structural connectivity, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 4821. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C., Mak H.K.F., Chan Q. and Hui S.K., The effect of small vessel disease lesions on structural brain network, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 1907. |
| Researcher : Li RA |
| Project Title: | Cell-based Heart Regeneration |
| Investigator(s): | Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2011 |
| Completion Date: | 09/2017 |
| Project Title: | Stem Cell and Regenerative Medicine |
| Investigator(s): | Li RA, Chan GCF, Tse HF |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Establishing a Molecular Encyclopedia for Stem Cell & Regenerative Medicine: Heart |
| Investigator(s): | Li RA, Tam PKH, Cheung YF |
| Department: | Dr. Li Dak-Sum Research Centre |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 2) |
| Start Date: | 08/2016 |
| Researcher : Li YV |
| List of Research Outputs |
| LEUNG L.L., Lam S.K., Li Y.V. and Ho J.C.M., Tumour Growth Suppressive Effect of Arsenic Trioxide in Squamous Cell Lung Carcinoma, Oncology letters. 2017, 14: 3748-3754. |
| Researcher : Lian Q |
| Project Title: | The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy |
| Investigator(s): | Lian Q |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2012 |
| Project Title: | The Roles and Mechanisms of RAP1/NFkb signaling pathway in MSC-induced immunomodulation for organ transplantation |
| Investigator(s): | Lian Q, Poon MW, He J |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application |
| Investigator(s): | Lian Q, Tse HF, Poon MW |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2013 |
| Project Title: | Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application |
| Investigator(s): | Lian Q, Tse HF, Poon MW |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 04/2013 |
| Project Title: | Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease |
| Investigator(s): | Lian Q, Wong DSH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION |
| Investigator(s): | Lian Q |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2013 |
| Project Title: | Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application |
| Investigator(s): | Lian Q, Tse HF, Poon MW |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 07/2013 |
| Project Title: | Functional roles of human ESC/iPSC-derived mesenchymal stem cell-deposited matrixes for improving survive and functions of retinal pigment epithelial cell (RPE) |
| Investigator(s): | Lian Q |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional Roles of Procollagen 2a1 in the Regulation of Nkx2.5+Cardiac Progenitor Cells for Myocardial Regeneration |
| Investigator(s): | Lian Q, Zhang Y |
| Department: | Ophthalmology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Human induced pluripotent stem cells derived-nucleus pulposus cells for intervertebral disc degeneration in rats |
| Investigator(s): | Lian Q, Zhang Y, Cheah KSE |
| Department: | Ophthalmology |
| Source(s) of Funding: | AO Spine Asia Pacific |
| Start Date: | 06/2016 |
| Project Title: | Regulation of mitochondrial transfer potency by Kif5b in mesenchymal stem cells to rescue mitochondrial dysfunction-provoked ganglion cell degeneration |
| Investigator(s): | Lian Q, Huang J, Chiu K |
| Department: | Ophthalmology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2016 |
| Project Title: | Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing |
| Investigator(s): | Lian Q, Tse HF, Yan B |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2017 |
| Project Title: | International Society of Stem Cell Research (ISSCR) 2018 annunal Meeting ; HUMAN ISOGENIC AND PATIENT’S PLURIPOTENT STEM CELLS TO MODEL BIETTI’S CRYSTALLINE RETINAL DYSTROPHY |
| Investigator(s): | Lian Q |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| Chan S., Lian Q., Cheung Y.F. and Chan G.C.F., Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis, Toxicology and Applied Pharmacology . 2018, 338: 148-158. |
| Ding Y., Liang X., Zhang Y.L., Yi L., Shum H.C., Chen Q., Chan B.P., Fan H.M., Liu Z.M., Tergaonkar V., Qi Z.Q., Tse H.F. and Lian Q., Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation, Cell Death & Disease. 2018, 9. |
| LI X., Michaeloudes C., Zhang Y., Wiegman C.H., Adcock I.M., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K.F., Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, Journal of Allergy and Clinical Immunology. 2018, 141: 1634-1645. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Liu H., Lo C.M., Yeung W.H., Li C., Liu X., Qi X., Ng K.T.P., LIU J., MA Y.Y., Lam Y.F., Lian Q., Chan S.C. and Man K., NLRP3 inflammasome induced liver graft injury through activation of telomere-independent RAP1/KC axis, The Journal of Pathology. 2017, 242(3): 284-296. |
| Qi X., Ng K.T.P., Lian Q., Li C., Geng W., Ling C., Yeung W.H.O., Ma Y.Y., Liu X., Liu H., Liu J., Yang X., Lo C.M. and Man K., Glutathione peroxidase 3 delivered by hiPSC-MSCs ameliorated hepatic IR injury via inhibition of hepatic senescence, Theranostics. 2018, 8(1): 212-222. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| ZHANG Z., Zhang Y., Gao F., HAN S., Cheah K.S.E., Tse H.F. and Lian Q., CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects, Molecular Therapy - Nucleic Acids. 2017, 9: 230-241. |
| Researcher : Liang RHS |
| List of Research Outputs |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Researcher : Liang X |
| List of Research Outputs |
| Ding Y., Liang X., Zhang Y.L., Yi L., Shum H.C., Chen Q., Chan B.P., Fan H.M., Liu Z.M., Tergaonkar V., Qi Z.Q., Tse H.F. and Lian Q., Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation, Cell Death & Disease. 2018, 9. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : Liang Y |
| List of Research Outputs |
| Fong Y.H., Liang Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Elucidation of epidermal growth factor receptor pathway in cigarette smoke medium-mediated expression of mucin genes and release of IL-8 in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 46. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Effects of fine particulate matter collected in Hong Kong in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Jouranal. 2018, 24 (Suppl.1): 45. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Mak J.C.W., CUI Y., Liu W.K.K., Liang Y. and Ip M.S.M., Selegiline suppressed cigarette smoke-induced oxidative stress and inflammation via MAO-B inhibition in rat lung, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A4752. |
| Researcher : Liao S |
| List of Research Outputs |
| Liao S. and Tse H.F., Potent Immunomodulation and Angiogenic Effects of Mesenchymal Stem Cells versus Cardiomyocytes Derived from Pluripotent Stem Cells for Treatment of Heart Failure, ISSCR Annual Meeting 2018. 2018. |
| Tanabe Y., Liao S., Zhen Z. and Tse H.F., High-performance wireless powering for peripheral nerve neuromodulation systems, PLOS ONE. 2017, 12: e0186698. |
| Researcher : Liu J |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Researcher : Liu SHK |
| List of Research Outputs |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Hui Y.T., Wong G., Liu S.H.K., ..... ......, Yuen R.M.F. and Wong V.W.S., Real world efficacy and tolerability of direct-acting antiviral for treatment of chronic hepatitis C infection: interim results of a territory-wide study in Hong Kong, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. 2018, 12 (Suppl 2): 1S519. |
| Hui Y.T., Wong G., Liu S.D., Liu S.H.K., Ma Y.K., But Y.K.D., .... ........, Yuen R.M.F. and Wong V.W.S., Territory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong, Journal of Gastroenterology and Hepatology. 2017, 32: 158-159. |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| Yuen R.M.F., Liu S.H.K., Given B., Schluep T., Hamilton J., Lai C.L., Locarnini S., Jackson K., Lai J.Y., Ferrari C. and Gish R.G..., RNA interference therapy with ARC-520 Injection results in long term off-therapy antigen reductions in treatment naïve, HBeAg positive and negative patients with chronic HBV, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S526. |
| Researcher : Liu WKK |
| List of Research Outputs |
| Fong Y.H., Liang Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Elucidation of epidermal growth factor receptor pathway in cigarette smoke medium-mediated expression of mucin genes and release of IL-8 in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 46. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Mak J.C.W., CUI Y., Liu W.K.K., Liang Y. and Ip M.S.M., Selegiline suppressed cigarette smoke-induced oxidative stress and inflammation via MAO-B inhibition in rat lung, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A4752. |
| Researcher : Lo WK |
| List of Research Outputs |
| Wong C.K.H., Chen J.Y., Fung S.K.S., Lo W.K., Lui S.L., Chan D.T.M., Cheng Y.L., Kong I.L.L., Wan Y.F. and Lam C.L.K., Health-related Quality of Life and Health Utility of Chinese Patients Undergoing Nocturnal Home Haemodialysis in comparison to Other Modes of Dialysis, Nephrology. 2018. |
| Researcher : Lui MSM |
| List of Research Outputs |
| Lui M.S.M., Kwok H.H., Chiang K.Y. and Lam C.L.D., Malignant Pleural Effusion from Lung Cancers with Driver Mutations, In: Shirin Shafazand, Current Pulmonology Reports. 2018, 7: 13-18. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., American Thoracic Society International Trainee Scholarship Award 2018 & American Thoracic Society-International Society for Respiratory Diseases Travel Award 2018, American Thoracic Society & American Thoracic Society-International Society for Respiratory Diseases, Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diabetes risk in a Chinese cohert. 2018, 197: A7696. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diebetes risk in a Chinese cohert, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A7696. |
| XU P., Lui M.S.M., Lam C.L.D., Ip M.S.M., Fong D.Y.T. and Hui K.M.C., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population., European Respiratory Society International Congress 2017, Milan Italy, Sep 2017, European Respiratory Journal. 2017, 50 (Suppl 61): PA 1185. |
| Researcher : Lui SL |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Wong C.K.H., Chen J.Y., Fung S.K.S., Lo W.K., Lui S.L., Chan D.T.M., Cheng Y.L., Kong I.L.L., Wan Y.F. and Lam C.L.K., Health-related Quality of Life and Health Utility of Chinese Patients Undergoing Nocturnal Home Haemodialysis in comparison to Other Modes of Dialysis, Nephrology. 2018. |
| Researcher : Luk JKH |
| List of Research Outputs |
| Luk J.K.H., Lau H.P., Ng W.C., Chan W.K., Fong C.H.C., Chan C.L.W., Chow A.Y.M. and Chan H.W.F., Understanding the facilitators and barriers of ACP with frail elderly: The experience of a geriatric outreach team in Hong Kong, 12th Asia Pacific Hospice Conference. 2017. |
| Researcher : MA CY |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| Researcher : Ma CH |
| Project Title: | The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms |
| Investigator(s): | Ma CH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents |
| Investigator(s): | Ma CH, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Generating transgenic zebrafish model to study the emerging role of autophagy and mitophagy in hematopoietic diseases |
| Investigator(s): | Ma CH, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Researcher : Ma KFO |
| List of Research Outputs |
| Yick L.W., Ma K.F.O., Ng C.L., Kwan S.C. and Chan K.H., Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice, Frontiers in Immunology . 2018, 9: 1438. |
| Researcher : Ma KMM |
| List of Research Outputs |
| Cheung C.Y.S., Ma K.M.M., Chak W.L. and Tang S.C.W., Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong, Medicine (Baltimore). 2017, 96(38): e8077. |
| Cheung C.Y.S., Ma K.M.M., Chak W.L., Chau K.F. and Tang S.C.W., Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. , Oncotarget. 2017, 8(27): 44833-44841. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Researcher : Mak JCW |
| Project Title: | Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population |
| Investigator(s): | Mak JCW, Chan MMW |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Therapeutic Potential of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells (hiPSC-MSCs) on oxidative stress-induced |
| Investigator(s): | Mak JCW |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Role of Dendrobium officinale polysaccharides in amelioration of cigarette smoke-induced mucus hypersecretion – relevant to chronic obstructive pulmonary disease |
| Investigator(s): | Mak JCW, Zhang Y |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 09/2018 |
| Project Title: | Amelioration of cigarette smoke-induced mucus hypersecretion by Dendrobium officinale polysaccharides – relevant to chronic obstructive pulmonary disease |
| Investigator(s): | Mak JCW, Zhang Y, Liang Y |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Benton M.J., Lim T.K., Ko F.W.S., Kan-O K. and Mak J.C.W., Year in review 2017: Chronic obstructive pulmonary disease and asthma, Respirology. 2018, 23: 538-545. |
| CHEN X., Leung G.P.H., Zhang Z., Xiao J.B., Lao L., Feng F., Mak J.C.W., Wang Y., Sze C.W.S. and Zhang Y., Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil, Food and Chemical Toxicology. 2017, 107: 248-260. |
| Fong Y.H., Liang Y., Liu W.K.K., Ip M.S.M. and Mak J.C.W., Elucidation of epidermal growth factor receptor pathway in cigarette smoke medium-mediated expression of mucin genes and release of IL-8 in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 46. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Comparative analysis of high-fat diet and intermittent hypoxia impacts on C57BL/6N and C57BL/6J mouse strains, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 25. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Differential effects of high fat diet and intermittent hypoxia on C57BL/6N and C57BL/6J mouse strains., American Thoracic Society International Conference, Sam Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A6407. |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| LI X., Michaeloudes C., Zhang Y., Wiegman C.H., Adcock I.M., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K.F., Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, Journal of Allergy and Clinical Immunology. 2018, 141: 1634-1645. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Effects of fine particulate matter collected in Hong Kong in human airway epithelial cells, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Jouranal. 2018, 24 (Suppl.1): 45. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Mak J.C.W., Novel targets for anti-inflammation in airway cells, Asian Federation of Pharmaceutical Sciences Conference (AFPS) 2017. 2017. |
| Mak J.C.W., CUI Y., Liu W.K.K., Liang Y. and Ip M.S.M., Selegiline suppressed cigarette smoke-induced oxidative stress and inflammation via MAO-B inhibition in rat lung, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A4752. |
| QIU Y., CHOW Y.T., Liang W., Chung W.W.Y., Mak J.C.W. and Lam J.K.W., From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery, Molecular Pharmaceutics. 2017, 14: 4606-4617. |
| WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-13. |
| Researcher : Mak W |
| List of Research Outputs |
| YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Cognitive impairments in chronic temporal lobe epilepsy patients: an event-related potential study of prospective memory, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 60. |
| Researcher : Man CH |
| List of Research Outputs |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Researcher : Mok MY |
| List of Research Outputs |
| Kwan P.Y.L., Mok M.Y., Choy C.B.Y. and Chan D.T.M., Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet, Nephrology. 2017, 22(10): 821-822. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Researcher : Mok MYT |
| List of Research Outputs |
| GAO Y., Cheung R.T.F., Gao J., Lau Y.Y.E., WAN H.Y. and Mok M.Y.T., Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement, Clinical EEG and Neuroscience. 2017, 48: 251-258. |
| Golder V., Kandane-Rathnayake R., Hoi A.Y., Huq M., Louthrenoo W., An Y., Li Z.G., Luo S.F., Sockalingam Z., Lau W.C.S., Mok M.Y.T., Lateef A., Franklyn K., Morton S., Navarra S.T., Zamora L., Wu Y.J., Hamijoyo L., Chan M., O’Neill S., Goldblatt F., Nikpour M. and Morand E.F., Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study, Arthritis Research & Therapy. 2017, 19. |
| Researcher : NG KK |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Researcher : NG YM |
| List of Research Outputs |
| Cheng C.W., LEONG K.W., NG Y.M., Kwong Y.L. and Tse E.W.C., The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27, Journal of Biological Chemistry. 2017, 292: 21431-21441. |
| Researcher : NING Z |
| List of Research Outputs |
| Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Exosomal microRNA-486-3p mediates acquired resistance to anaplastic lymphoma kinase inhibitor in EML4-ALK translocated lung adenocarcinoma, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 33. |
| Researcher : Ng CL |
| Project Title: | Small molecule of Adiponectin receptor agonist, AdipoRon - a potential therapeutic medication for Alzheimer's disease |
| Investigator(s): | Ng CL, Chan KH, Chung SK |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | The 5th International Conference on Molecular Neurodegeneration (ICMN2018); AdipoRon, a adiponectin receptor agonist, rescues cognitive deficits, reduced Alzheimer’s disease pathologies and prevented neurodegeneration by enhancing neuronal insulin sensitivity in 5XFAD mice |
| Investigator(s): | Ng CL |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| Yick L.W., Ma K.F.O., Ng C.L., Kwan S.C. and Chan K.H., Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice, Frontiers in Immunology . 2018, 9: 1438. |
| Researcher : Ng KM |
| Project Title: | Novel Therapeutic Approach for X-linked related Danon Disease Insight from Patient-specific Pluripotent Stem Cells Platform. |
| Investigator(s): | Ng KM, Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Clinical Insight into Xi-chromosome Reactivation and its Therapeutic Potential in X-linked cardiomyopathies and related disorders. |
| Investigator(s): | Ng KM, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Patient-specific isogenic iPSCs-derived cardiomyocytes as a clinically relevant platform for the identification of therapeutic targets for Rett syndrome |
| Investigator(s): | Ng KM, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Researcher : Ngai WS |
| List of Research Outputs |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Researcher : Pai MCP |
| List of Research Outputs |
| Xing F., Ye H., Yang J., Chan J.F.W., Seto W.K.W., Pai M.C.P., Yuen K.Y. and Hung L.L., Fatal pancytopenia due to albendazole treatment for strongyloidiasis, IDCases. 2018, 12: 112-116. |
| Researcher : Pan Y |
| List of Research Outputs |
| Hoo R.L.C., Pan Y., Shu L., Lam K.S.L. and Xu A., Adipocyte Fatty Acid Binding Protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11-15 Sep 2017, Lisbon. 2017. |
| Researcher : Pang KPP |
| List of Research Outputs |
| To K.K.W., Lai C.Y.W., NG C.K., Ho T.Y., Pang K.P.P., Yip C.Y., Poon W.S.R. and Hung F.N.I., Prospective evaluation of the use of saliva specimens in the detection of respiratory viruses using a self-contained microfluidic based multiplex molecular assay, 28th European Congress of Clinical Microbiology & Infectious Diseases. 2018. |
| Researcher : Pang SYY |
| List of Research Outputs |
| Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15. |
| Pang S.Y.Y., Teo K.C., Hsu J.S., Chang S.K.R., Li M., Sham P.C. and Ho S.L., The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review, Translational Neurodegeneration. United Kingdom, BioMed Central, 2017, 6: 27. |
| Researcher : Poon MW |
| List of Research Outputs |
| Zhang X.Q., Wang Z.E.-.L.I.N., Poon M.W. and Yang J.I.A.N.-.H.U.A., Spatial-temporal Transcriptional Dynamics of Long Non-coding RNAs in Human Brain , Human Molecular Genetics. 2017, 16: 3202-3211. |
| Researcher : Ran X |
| List of Research Outputs |
| Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017. |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Researcher : Seto WKW |
| Project Title: | Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure |
| Investigator(s): | Seto WKW, Kwong YL, Lie AKW, Wong DKH, Lai CL, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2013 |
| Completion Date: | 10/2017 |
| Project Title: | Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B |
| Investigator(s): | Seto WKW, Wong DKH, Fung JYY, Lai CL, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 12/2014 |
| Completion Date: | 12/2018 |
| Project Title: | Proteomic screening for potential protein biomarker(s) associated with spontaneous HBsAg seroclearance in patients with chronic hepatitis B infection |
| Investigator(s): | Seto WKW, Wong DKH, Huang FY, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Completion Date: | 03/2018 |
| Project Title: | Metabolic determinants of fibrosis reversal in advanced chronic hepatitis B during long-term nucleoside analogue therapy |
| Investigator(s): | Seto WKW, Lam KSL, Yuen RMF, Wong DKH, Fung JYY, Lee CHP |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2016 |
| Project Title: | Diabetes mellitus and liver fibrosis regression in nucleoside analogue-treated chronic hepatitis B: a prospective matched case-control evaluation using multiparametric magnetic resonance imaging and transient elastography |
| Investigator(s): | Seto WKW, Chiu WHK, Lee CHP, Fung JYY, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Outstanding Young Researcher Award 2016-17 |
| Investigator(s): | Seto WKW |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2018 |
| Project Title: | The interactive role of Paneth cells and the gut microbiota in a non-alcoholic fatty liver disease animal model |
| Investigator(s): | Seto WKW, Yuen RMF, Wong DKH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| Project Title: | Serum Enhanced Liver Fibrosis (ELF): A Validated Marker for the Non-invasive Diagnosis of Advanced Liver Fibrosis and Cirrhosis |
| Investigator(s): | Seto WKW, Lee CHP, Yuen MAM, Wong DKH, Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Agarwal K., Brunetto M., Seto W.K.W., Lim Y.S., Fung S., Marcellin P., Ahn S.H., Izumi N., Chuang W.L., Bae H., Sharma M., Janssen H., Pan C., Celen M.K., Furusyo N., Shalimar D., Yoon K.T., Trinh H. and Chan H.L., 96 weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection, Journal of Hepatology. Elsevier, 2018, 68: 672-681. |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015, Clin Transl Gastroenterol. 2017, 8(8): e116. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis, World Journal of Gastroenterology. 2017, 23: 7863-7874. |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Cheung K.S.M., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016, World Journal of Gastroenterology. 2017, 23: 7716-7726. |
| Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleos(t)ide analogs alone after liver transplantation in chronic hepatitis B with preexisting rt204 mutation, Transplantation. 2017, 101(10):: 2391-2398. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Mak K.W., Ng K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Prevalence of graft steatosis after liver transplantation using controlled attenuation parameter measurements: a large cohort study, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 914A. |
| Gane E., Seto W.K.W., Janssen H., Carantu F.A., Kim H.J., Abdurakhmanov D., Nishiguchi S., Andrzej H., Bae H., Mo S., Suri V., Gaggar A., Flaherty J.F., Kao J.H., Brunetto M. and Ferret M.B., Safety and efficacy at 1 year after switching from Tenofovir Disoproxil Fumurate to Tenofovir Alafenamide in chronic HBV patients with risk factors for TDF use, Journal of Hepatology. 2018, 68: S87. |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., An update on the toxicological considerations for protease inhibitors used for hepatitis C infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14(5): 483-491. |
| Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Hepatitis B core protein as a therapeutic target, Expert Opinion on Therapeutic Targets. 2017, 21: 1153-1159. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., Pharmacokinetic evaluation of besifovir for the treatment of HBV infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14: 101-106. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, Alimentary Pharmacology & Therapeutics. 2018, 47: 43-54. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection, Clinical and Translational Gastroenterology. 2018, 9: 163. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Sawai H., Nishida N., Khor S.S., Masao H., Sugiyama M., Baba N., Yamada K., Sawada N., Tsugane S., Koike K., Kondo Y., Yatsuhashi H., Nagoaka S., Taketomi A., Fukai M., Kurosaki M., Izumi N., Kang J.H., Murata K., Hino K., Nishina S., Matsumoto A., Tanaka E., Sakamoto N., Ogawa K., Yamamoto K., Tamori A., Yokosuka O., Kanda T., Sakaida I., Itoh Y., Eguchi Y., Oeda S., Mochida S., Yuen R.M.F., Seto W.K.W., Poovorawan Y., Posuwan N., Mizokami M. and Tokunaga K., Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma, Scientific Reports. 2018, 8. |
| Seto W.K.W., Lai C.L. and Yuen R.M.F., Adefovir dipivoxil, In: Grayson ML, Crowe S, MaCarthy M, Mills J. Mouton J, Paterson DL, Cosgrove SE, Hope W, Kucers' The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs. CRC Press, 2017, 255: 3-15. |
| Seto W.K.W., Advance in liver cirrhosis and fibrosis , 6th Cross-strait Digestive Forum, Nanjing, 2017. |
| Seto W.K.W., Advances in Diagnostics: Anti-HBc and HBcrAg, Asia-Pacific Digestive Week, Hong Kong. 2017. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| Seto W.K.W., Guangdong Province Outstanding Young Medical Talent Award, 廣東省傑出青年醫學人才, 廣東省衛計委, 2018. |
| Seto W.K.W., HBV and Immunosuppression: What is the risk? Hong Kong Medical Association Symposium, 2017. |
| Seto W.K.W., HCV Experience and Unmet Needs in Hong Kong – What are the Solutions?, HKASLD Symposium, 2017. |
| Seto W.K.W., HCV Experience and Unmet Needs in Hong Kong – What are the Solutions?, Hong Kong Association for the Study of Liver Diseases Dinner Symposium. 2017. |
| Seto W.K.W., Hepatitis B and pregnancy, Hong Kong Sanatorium Hospital Continuous Medical Education Meeting, 2017. |
| Seto W.K.W., Highlights of AASLD 2017. Hong Kong Association for the Study of Liver Disease and Wiley Hong Kong, 2018. |
| Seto W.K.W., Asahina Y., Brown T.T., Peng C.Y., Stanciu C., Abdurakhmanov D., Tabak F., Nguyen T.T., Chuang W.L., Inokuma T., Ikeda F., Santantonio T.A., Habersetzer F., Ramji A., Lau A.H., Suri V., Flaherty J.F., Wang H., Gaggar A., Subramanian G.M., Mukewar S., Brunetto M.R., Fung S. and Chan H.L., Improved Bone Safety of Tenofovir Alafenamide Compared to Tenofovir Disoproxil Fumarate Over 2 Years in Patients With Chronic HBV Infection, Clinical Gastroenterology and Hepatology. 2018. |
| Seto W.K.W., Mak S.K., Chiu W.H.K., Vardhanabhuti V., Wong H.F., Leong H.T., Lee P., Ho Y.C., Lee C.K., Cheung K.S., Yuen R.M.F. and Leung W.K., Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users, Journal of Hepatology. 2018. |
| Seto W.K.W., Outstanding Young Researcher Award 2016-2017, The University of Hong Kong. 2018. |
| Seto W.K.W., Fung S., Hou J., Pan C., Chuang W.L., Chang T.T., Hui A.J., Chen C.Y., Ma X., Tam E., Tsang T.Y., Yang J., Flaherty J.F., Gaggar A., Mo S., Tong M., Kao J.H. and Chan H.L., Tenofovir alafenamide (TAF) compared with Tenofovir Dispoproxil Fumarate (TDF) in patients with chronic HBV: week 96 efficacy and safety results in Chinese patients enrolled in 2 overseas phase 3 studies., 磷丙替诺福韦（TAF）和富马酸替诺福韦二吡呋酯（TDF）用于慢性HBV患者的疗效比较：纳入2项海外3期研究的华裔患者治疗96周的疗效, Chinese Infectious Disease and Hepatology Conference. 2017. |
| Seto W.K.W., The era of direct antiviral therapy in HCV. Gilead Hepatitis Educational Forum, Shenzhen, 2017. |
| Seto W.K.W., 深圳市科教工作先進工作者 2017, 深圳市衛計委, 2018. |
| Singh G.H.H., Leung G.M.K., Seto W.K.W. and Kwong Y.L., Risk of viral reactivation in patients with occult hepatitis B virus infection during ruxolitinib treatment, Annals of Hematology. 2018. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Wong D.K.H., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Occult hepatitis B infection in hepatocellular carcinoma patients with negative HBsAg, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S474. |
| Wong G.L.H., Seto W.K.W., Wong V.W.S., Yuen R.M.F. and Chan H.L., Review article: long-term safety of oral anti-viral treatment for chronic hepatitis B, Alimentary Pharmacology & Therapeutics. 2018, 47: 730-737. |
| Xing F., Ye H., Yang J., Chan J.F.W., Seto W.K.W., Pai M.C.P., Yuen K.Y. and Hung L.L., Fatal pancytopenia due to albendazole treatment for strongyloidiasis, IDCases. 2018, 12: 112-116. |
| Zhu R.X., Yang D. and Seto W.K.W., Impact of wild-type and carboxyl-terminal truncated hepatitis B virus X on hepatocyte proliferation, HBx蛋白及其羧基末端缺失35个氨基酸的突变体对正常肝细胞增殖的影响, World Chinese Journal of Digestology. 世界华人消化杂志, 2018, 26: 760-768. |
| Researcher : Shen J |
| Project Title: | Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells |
| Investigator(s): | Shen J |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2003 |
| Project Title: | Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions |
| Investigator(s): | Shen J, Yang D, Chen X |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural stem/progenitor cells through activating Notch signaling pathway |
| Investigator(s): | Shen J, So KF, Chung SK |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Exploring Caveolin-1 as a Novel Molecular Target for Hampering T lymphocytes Infiltration through Blood Brain Barrier and Attenuating Disease Progress in Experimental Autoimmune Encephalomyelitis |
| Investigator(s): | Shen J, Chan GCF, Wu W |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Completion Date: | 10/2017 |
| Project Title: | Exploring HMGB1 signaling as molecular target in peroxynitrite-mediated blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy |
| Investigator(s): | Shen J, Yang D, Chung SK |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2015 |
| Project Title: | Elucidating Impacts of Reactive Nitrogen Species-mediated Excessive Mitophagy on Cerebral Ischemic-Reperfusion Injury and Exploring the Neuroprotective Mechanisms of Naringin for Inhibition of Excessive Mitophagy |
| Investigator(s): | Shen J, Chen X |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Exploring Effects of Glycyrrhizin, an Active Compound from Glycyrrhizae Radix, on Attenuating Delayed Tissue-plasminogen Activator (t-PA) Treatment-induced Hemorrhagic Transformation in Ischemic Stroke |
| Investigator(s): | Shen J, Chen X, Fung ML, Chen H |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Project Title: | Evaluating the neuroprotective effect and safety of An-Gong-Niu-Huang Wan and its ingredients in ischemic stroke |
| Investigator(s): | Shen J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 06/2016 |
| Project Title: | Exploring Molecular Targets for Drug Discovery to Preventing Hyperglycemia-mediated Hemorrhagic transformation in Ischemic Stroke: Sodium Danshensu (SDSS) as an Example |
| Investigator(s): | Shen J, Siu DCW, Chung SK |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2017 |
| Researcher : Shiu SWM |
| List of Research Outputs |
| Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-β1 HDL in type 2 diabetes mellitus., Atherosclerosis.. 2017, 263: 24-28. |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219. |
| Tan K.C.B., Shiu S.W.M., Lam K.Y.J., Lee C.H.A. and Wong Y., Serum galectin-3 and all-cause mortality in type 2 diabetes., American Diabetes Association 78th Scientific Sessions, Orlando, USA.. 2018. |
| Tan K.C.B., Shiu S.W.M. and Wong Y., Serum galectin-3 predicts progressive kidney disease in type 2 diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon,.. 2017. |
| Researcher : Shu L |
| Project Title: | AMERICAN DIABETES ASSOCIATION 78TH SCIENTIFIC SESSIONS; Pharmacological Inhibition of Neutrophil Elastase Attenuates Insulitis &Autoimmune Diabetes in Mice |
| Investigator(s): | Shu L |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Completion Date: | 06/2018 |
| List of Research Outputs |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018. |
| Hoo R.L.C., Pan Y., Shu L., Lam K.S.L. and Xu A., Adipocyte Fatty Acid Binding Protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11-15 Sep 2017, Lisbon. 2017. |
| Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018. |
| Shu L., Zhong L., Xiao Y., Hoo R.L.C. and Xu A., Pharmacological Inhibition of Neutrophil Elastase Attenuates Insulitis &Autoimmune Diabetes in Mice , American Diabetes Association 78th Scientific sessions . 2018. |
| WU X., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., The Role of Adipocyte Fatty Acid Binding Protein in the Development of Liver Fibrosis, American Diabetes Association 78th Scientific Sessions, 22-26 Jun 2018, Orlando, FL. 2018. |
| Researcher : Singh GHH |
| Project Title: | Mechanisms of leukaemic transformation from myelodysplastic syndromes (MDS) failing treatment with demethylating agents. |
| Investigator(s): | Singh GHH, Kwong YL, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Determination of Prognosis in Patients with Myelofibrosis Using Novel Molecular Markers |
| Investigator(s): | Singh GHH, Kwong YL, So JCC |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2016 |
| Completion Date: | 01/2018 |
| Project Title: | Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide |
| Investigator(s): | Singh GHH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Hwang Y.Y.G., Singh G.H.H., Chan S.Y.T., Leung G.M.K., Cheung C.Y.M. and Kwong Y.L., Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting, Hematology. 2018, 1-6. |
| Kwong J.H.Y., Leung R.Y.Y., Wong M.L.G., Singh G.H.H. and Kwong Y.L., Primary myelofibrosis presenting in acute promyelocytic transformation, British Journal of Haematology. 2017, 178: 349-349. |
| Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017. |
| Singh G.H.H., Best Abstract in Clinical Medicine, Medical Research Conference 2018., Department of Medicine, LKS Faculty of Medicine, the University of Hong Kong.. 2018. |
| Singh G.H.H., Clofarabine, New Drugs Forum 2017, Department of Medicine, the University of Hong. 2017. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017. |
| Singh G.H.H., Leung G.M.K., Seto W.K.W. and Kwong Y.L., Risk of viral reactivation in patients with occult hepatitis B virus infection during ruxolitinib treatment, Annals of Hematology. 2018. |
| Singh G.H.H., Ruxolitinib, New Drugs Forum 2017, Department of Medicine, the University of Hong Kong. 2017. |
| Researcher : Siu DCW |
| Project Title: | Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model |
| Investigator(s): | Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 10/2008 |
| Project Title: | Fabrication of Bio-artificial Atrio-Ventricular Node for Biological Pacing combining 3D Bio-printing and Induced Pluripotent Stem Cell Technology |
| Investigator(s): | Siu DCW |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Territory-wide pulmonary hypertension screening amongst partients with connective tissue diseases: A prospective screening study |
| Investigator(s): | Siu DCW |
| Department: | Medicine |
| Source(s) of Funding: | Actelion Pharmaceuticals Hong Kong Limited |
| Start Date: | 09/2017 |
| List of Research Outputs |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Fang J.X., Fang B.X., Lam C.C., Chan P.H.M., Tam C.C. and Siu D.C.W., Extrinsic pulmonary artery compression mimicking acute pulmonary embolism, Clinical Case Reports. 2017, 5: 1591-1593. |
| HUANG D., Wong C.L., Cheng K.W., Chan P.H.M., Yue W.S., Wong C.K., Ho C.W., Wong I.C.K., Chan E.W. and Siu D.C.W., Impact of provision of time in therapeutic range value on anticoagulation management in atrial fibrillation patients on warfarin, Postgraduate Medical Journal. 2018, 94: 207-211. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| HUANG D., Chan P.H.M., She H.L., Wong C.K., Ho C.W., Cheng Y.Y., Chan E.W., Chiang C.E. and Siu D.C.W., Secular trends and etiologies of venous thromboembolism in Chinese from 2004 to 2016, Thrombosis Research. 2018, 166: 80-85. |
| Hai S.H.J.J., Un K.C., Wong C.K., Wong K.L., Zhang Z.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Prognostic implications of early monomorphic and non–monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome, Heart Rhythm. 2018, 15: 822-829. |
| LAU C.Y., Li X., Wong I.C.K., Man K.C.K., Lip G.Y.H., Leung W.K., Siu D.C.W. and Chan E.W., Bleeding-Related Hospital Admissions and 30-Day Re-Admissions in Patients with Nonvalvular Atrial Fibrillation Treated with Dabigatran versus Warfarin, Journal of Thrombosis and Haemostasis. 2017, 15: 1923-1933. |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Poh M.Z., Poh Y.C., Chan P.H.M., Wong C.K., Pun L., Leung W.W.C., Wong Y.F., Wong M.M.Y., Chu D.W.S. and Siu D.C.W., Diagnostic assessment of a deep learning system for detecting atrial fibrillation in pulse waveforms, Heart. 2018, heartjnl-2018-313147. |
| Siu D.C.W., 2017 Invited Speaker, ,1st Asia Pacific Pulmonary hypertension Forum, Kuala Lumpur, Malaysia: “Hot Topics by country”, 2017. |
| Siu D.C.W., 2017 Invited Speaker, Macau Cardiology Association Annual Scientific Meeting 2017, Macau “PCSK9 inhibitors – which patients will it benefit the most? - ACC/AHA and ESC guidelines update on pharmacological treatment in heart failure management”, 2017. |
| Siu D.C.W., 2018 Invited Speaker, 23rd medical research Conference, “Irregularly Irregular pulse: To impact clinical practice with research”, 2018. |
| Siu D.C.W., 2018 Invited Speaker, Association of Hong Kong Nursing Staff, “Practical Tips for stroke prevention in atrial fibrillation in Chinese”, 2018. |
| Siu D.C.W., 2018 Invited Speaker, Hong Kong Empagliflozin Advisory Board Meeting, “ Human induced pluripotent stem cell for DM Cardiomyopathy modeling”, 2018. |
| Siu D.C.W., 2018 Invited Speaker, Multidisciplinary Approach of Updated Atrial Fibrillation Management, “Growing burden of Atrial fibrillation in Hong Kong: the best clinical practice to react”, 2018. |
| Siu D.C.W., 2018 Invited Speaker,23rd Hong Kong Medical Forum, “Stroke Prevention in High Risk AF Patients”, 2018. |
| Siu D.C.W., 2018 Invited Speaker,Multi-specialty Medical Mega Conference Eighth Round, “Telecardiology in screening of heart failure”, 2018. |
| Siu D.C.W., Invited Speaker, Update on Diabetes Management 2017. “Diabetes and the heart”, 2018. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| Wong C.K., Chan P.H.M., Lam C.C.S., Kwok O.H., Lam Y.Y. and Siu D.C.W., WATCHMAN device-related thrombus successfully treated with apixaban, Medicine. 2017, 96: e8693. |
| Researcher : TSOI MF |
| List of Research Outputs |
| FEI Y., TSOI M.F., Kumana C.R., Cheung T.T. and Cheung B.M.Y., Network meta-analysis of cardiovascular outcomes in randomized controlled trials of new antidiabetic drugs, International Journal of Cardiology. 2018, 254: 291-296. |
| Researcher : Tam S |
| List of Research Outputs |
| Li R.H.W., Lam K.S.L., Tam S., Wong E., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction Of Metabolically Unhealthy Phenotype By The Visceral Accumulation Index, Lipid Accumulation Index And Triglyceride-glucose Index In Chinese Women With Polycystic Ovary Syndrome, European Society of Human Reproduction and Embryology Annual Meeting, 2-5 Jul 2017, Geneva, Switzerland. 2017. |
| Researcher : Tan KCB |
| Project Title: | Genetic Screening of Familial Hypercholesterolemia in Hong Kong |
| Investigator(s): | Tan KCB, Yeung CY, Siu DCW, Leung YYJ, Pang HK, Cheung CL |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Completion Date: | 10/2017 |
| Project Title: | Role of the inducible degrader of low-density lipoprotein receptor (IDOL) in lipoprotein metabolism |
| Investigator(s): | Tan KCB, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Cheung C.L., Tan K.C.B. and Kung A.W.C., Cohort Profile: The Hong Kong Osteoporosis Study and the follow-up study, International Journal of Epidemiology. 2018, 47: 397-398f. |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Jiao F., Wong C.K.H., Tang S.C.W., Fung S.C.C., Tan K.C.B., McGhee S., Gangwani R.A. and Lam C.L.K., Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong., Diabet Med.. 2018, 34(9): 1276-1283. |
| Jiao F., Wong C.K.H., Gangwani R.A., Tan K.C.B., Tang S.C.W. and Lam C.L.K., Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications, Health and Quality of Life Outcomes. 2017, 15: 125. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgrad Med J. 2017, 93 (1101): 373-375. |
| Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Absolute benefits of empagliflozin in type 2 diabetes: a game changer?, Postgraduate Medical Journal. 2017, 93: 373-375. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| Moayyeri A., Cheung C.L., Tan K.C.B., Morris J.A., Cerani A., Mohney R.P., Richards J.B., Hammond C., Spector T. and Menni C., Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization Study, Journal of Bone and Mineral Research. 2018, 33: 643-650. |
| Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-β1 HDL in type 2 diabetes mellitus., Atherosclerosis.. 2017, 263: 24-28. |
| Tan K.C.B., From efficacy to effectiveness: the impact of CVD-REAL study., Hong Kong College of Family Physicians 40th Anniversary Conference, Hong Kong.. 2017. |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219. |
| Tan K.C.B., HDL dysfunction in type 2 diabetes mellitus., The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul 2017, Hiroshima.. 2017. |
| Tan K.C.B., HDL dysfunction: what do we have to know?, 11th Congress of the Asian Pacific society of Atherosclerosis and Vascular Diseases. Iloilo city, Philippines.. 2018. |
| Tan K.C.B., Hong Kong University Press., "Problem-Based Medical Case Management".. 2017. |
| Tan K.C.B., Path towards new paradigm: incretin versus insulin treatment., Plenary lecture at diabetes Summit, Malaysian Endocrine and Metabolic society. Kuala Kumpur, Malaysia.. 2017. |
| Tan K.C.B., Perioperative management of diabetic patients - perspective from an endocrinologist., 2nd Hong Kong Evidence Based Perioperative Medicine Symposium.. 2018. |
| Tan K.C.B., Progess in pituitary disorders., Guangdong Province CME Meeting for Physicians, Shenzhen, China.. 2018. |
| Tan K.C.B., Shiu S.W.M., Lam K.Y.J., Lee C.H.A. and Wong Y., Serum galectin-3 and all-cause mortality in type 2 diabetes., American Diabetes Association 78th Scientific Sessions, Orlando, USA.. 2018. |
| Tan K.C.B., Shiu S.W.M. and Wong Y., Serum galectin-3 predicts progressive kidney disease in type 2 diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon,.. 2017. |
| Researcher : Tan V.P.Y. |
| Project Title: | Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients |
| Investigator(s): | Tan VPY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2011 |
| Project Title: | Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study |
| Investigator(s): | Tan VPY, Panagiotou I, Dufay S, Poon TCJ |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Factors driving a response in functional dyspepsia subjects treated with Rifaximin: Effect on upper gastrointestinal gas production, pH, transit time, mucosal histopathology. |
| Investigator(s): | Tan VPY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Researcher : Tan VPY |
| Project Title: | Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients |
| Investigator(s): | Tan VPY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2011 |
| Project Title: | Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study |
| Investigator(s): | Tan VPY, Panagiotou I, Dufay S, Poon TCJ |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Factors driving a response in functional dyspepsia subjects treated with Rifaximin: Effect on upper gastrointestinal gas production, pH, transit time, mucosal histopathology. |
| Investigator(s): | Tan VPY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Chu H.S., Yao C.K. and Tan V.P.Y., Food Therapy in Sinosphere Asia, Journal of Clinical Gastroenterology. 2017, 28: EPub. |
| Tan V.P.Y., Chu H.S., Yao C.K. and Gibson P.R., Lactulose, Lactose and Fructose Ingestion Induces Specific Patterns of Gastrointestinal Symptoms in Chinese Subjects with Functional Dyspepsia and Irritable Bowel Symptoms., United Gastroenterology Week. 2017. |
| Yao C.K., Chu H.S. and Tan V.P.Y., Hydrogen Breath Testing In East And Southeast Asia, Journal of Clinical Gastroenterology. 2017. |
| Researcher : Tang CW |
| Project Title: | Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study |
| Investigator(s): | Tang SCW, Lai KN |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | King's/HKU Fellowship Awards 2012-13 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 07/2012 |
| Project Title: | Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Completion Date: | 01/2019 |
| Project Title: | Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial |
| Investigator(s): | Tang SCW, Feng Y |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy |
| Investigator(s): | Tang SCW, Liu Y, Yiu WH |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies |
| Investigator(s): | Tang SCW, Liu Y, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Outstanding Researcher Award 2015-16 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 11/2016 |
| Project Title: | Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction |
| Investigator(s): | Tang SCW, Ma KMM, Chan JFW |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Society of Nephrology Ltd. |
| Start Date: | 12/2016 |
| Project Title: | Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis |
| Investigator(s): | Tang SCW, Yiu WH |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2017 |
| Project Title: | Efficacy, safety and response predictors of adjuvant Astragalus therapy for diabetic kidney disease – an open-label randomised controlled trial with responder regression analysis |
| Investigator(s): | Tang SCW, Chan KW, Zhang Y |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Dissecting the anti-inflammatory properties of kallistatin in diabetic nephropathy |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Society of Nephrology Ltd. |
| Start Date: | 11/2017 |
| List of Research Outputs |
| Researcher : Tang SCW |
| Project Title: | Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study |
| Investigator(s): | Tang SCW, Lai KN |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | King's/HKU Fellowship Awards 2012-13 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 07/2012 |
| Project Title: | Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Completion Date: | 01/2019 |
| Project Title: | Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial |
| Investigator(s): | Tang SCW, Feng Y |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy |
| Investigator(s): | Tang SCW, Liu Y, Yiu WH |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies |
| Investigator(s): | Tang SCW, Liu Y, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Outstanding Researcher Award 2015-16 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 11/2016 |
| Project Title: | Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction |
| Investigator(s): | Tang SCW, Ma KMM, Chan JFW |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Society of Nephrology Ltd. |
| Start Date: | 12/2016 |
| Project Title: | Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis |
| Investigator(s): | Tang SCW, Yiu WH |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4 |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2017 |
| Project Title: | Efficacy, safety and response predictors of adjuvant Astragalus therapy for diabetic kidney disease – an open-label randomised controlled trial with responder regression analysis |
| Investigator(s): | Tang SCW, Chan KW, Zhang Y |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Dissecting the anti-inflammatory properties of kallistatin in diabetic nephropathy |
| Investigator(s): | Tang SCW |
| Department: | Medicine |
| Source(s) of Funding: | Hong Kong Society of Nephrology Ltd. |
| Start Date: | 11/2017 |
| List of Research Outputs |
| CHEN X., LAM K.H., CHEN Q., Leung G.P.H., Tang S.C.W., Sze C.W.S., Xiao J., Feng F., Wang Y., Zhang Y. and Zhang Z., Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats, Food and Chemical Toxicology. 2017, 110: 49-61. |
| Chan G.C.W., Lee C.H.P., Kwan P.Y.L., Yip T.P.S. and Tang S.C.W., Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism, Nephrology. 2017, 22: 572-572. |
| Chan G.C.W. and Tang S.C.W., SGLT2 Inhibitor Empagliflozin: Finally at the Latter Stage of Understanding., Kidney Int (in press). 2017, 2017. |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Cheung C.Y.S., Ma K.M.M., Chak W.L. and Tang S.C.W., Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong, Medicine (Baltimore). 2017, 96(38): e8077. |
| Cheung C.Y.S., Ma K.M.M., Chak W.L., Chau K.F. and Tang S.C.W., Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. , Oncotarget. 2017, 8(27): 44833-44841. |
| Hill C., Price G.W., Wall M.J., Kaufmann T.J., Tang S.C.W., Yiu W.H. and Squires P.E., Transforming Growth Factor Beta 1 Drives a Switch in Connexin Mediated Cell-to-Cell Communication in Tubular Cells of the Diabetic Kidney, Cell Physiol Biochem. 2018, 2018: 45(6):2369-2388. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Jiao F., Wong C.K.H., Tang S.C.W., Fung S.C.C., Tan K.C.B., McGhee S., Gangwani R.A. and Lam C.L.K., Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong., Diabet Med.. 2018, 34(9): 1276-1283. |
| Jiao F., Wong C.K.H., Gangwani R.A., Tan K.C.B., Tang S.C.W. and Lam C.L.K., Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications, Health and Quality of Life Outcomes. 2017, 15: 125. |
| Lai K.N., Lai A.S. and Tang S.C.W., Viral nephropathies, Scientific American Nephrology, Dialysis and Transplantation, Edited by Ajay K Singh and Leonardo V Riella, Decker Intellectual Properties Inc., . Decker Intellectual Properties Inc., 2017, 2017. |
| Ma M.K., Yap Y.H.D., Li C.L., Mok M.M., Chan G.C., Kwan L.P., Lai K.N. and Tang S.C.W., Enteric coated Mycophenolate Sodium combined with low-dose steroid as first time therapy in minimal change nephrotic syndrome: an open label randomized controlled study, Oncotarget Advance publication . 2018, 2018. |
| Ma M.K., Law H.K., Tse K.S., Chan K.W., Chan G.C., Yap Y.H.D., Mok M.M., Kwan L.P., Tang S.C.W., Choy B.Y. and Chan D.T.M., Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis, Int J Urol. 2018, 2018: 25(5):450-455. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Tang S.C.W., "CKD Prevention & the PD first Policy - Perspectives in Hong Kong", 38th Annual Meeting of the Indian Society of Nephrology Southern Chapter Chapter Conference, Feb 9, 2018, Hyderabad India. 2018. |
| Tang S.C.W., "CKD Prevention - Perspectives in Hong Kong" , ISN North & East Asia Regional Workshop at the 2nd International Congress of Chinese Nephrologists, Dec 9, 2017, Taipei, Taiwan. 2017. |
| Tang S.C.W., "Clinical Trials in Diabetic Kidney Disease: Where are We?" , 16th Asian Pacific Congress of Nephrology, Mar 28, 2018, Beijing China. 2018. |
| Tang S.C.W., "Diabetes and Dialysis: Controversies in choice of modality", 16th Asian Pacific Congress of Nephrology, Mar 30, 2018, Beijing China. 2018. |
| Tang S.C.W., "Diabetic Nephropathy: What is the new progress in 2018?" , Nanjing International Nephrology Forum & National CME Course, Jun 23-24, 2018, Nanjing China. 2018. |
| Tang S.C.W., "Diabetic nephropathy: treatment and research" , Hong Kong Association for Integration of Chinese-Western Medicine (HKAIM), 24 Apr 2018. 2018. |
| Tang S.C.W., "Diagnosis and treatment of obstructive sleep apnea in CKD patients" 2018, 上海肾脏国际论坛暨上海市医师协会肾脏内科医师分会第四届年会, Jun 30, 2018, Shanghai, China . 2018. |
| Tang S.C.W., "Disease burden and novel treatments for the management of hyperkalaemia and anaemia in CKD", Hong Kong Medical Forum, 6 May 2018. 2018. |
| Tang S.C.W., "High Blood Pressure and Chronic Kidney Disease", Hypertension Forum, 17 Mar 2018. 2018. |
| Tang S.C.W., "Hypertension and Chronic Kidney Disease", 5th Brunei International Nephrology Conference, Apr 21, 2018. 2018. |
| Tang S.C.W., "IgA Nephropathy: 50 years on", 38th Korean Society of Nephrology Annual Meeting, May 18, 2018, Seoul Korea. 2018. |
| Tang S.C.W., "Inflammation in diabetic kidney disease" , ISN Frontiers Meeting, International Society of Nephrology, Feb 24, 2018, Tokyo Japan. 2018. |
| Tang S.C.W., "New developments in diabetic kidney disease" , Annual Meeting of Jiangsu Key Labortaory of Pediatrics, Jan 11, 2018, Nanjing. 2018. |
| Tang S.C.W., "PD first policy in Hong Kong", 5th Brunei International Nephrology Conference, Apr 21, 2018, Brunei Darussalem. 2018. |
| Tang S.C.W., "Process of Care and Payment for ESRD in Asia" in a symposium entitled: International Models of Dialysis., American Society of Nephrology Kidney Week, Nov 3, 2017, New Orleans, USA. 2017. |
| Tang S.C.W., "Proteinuria reduction in nephropathies: how much?" Oct 21, 2017, Xian. 2017. |
| Tang S.C.W., "Recent advances and tribulations in the management of diabetic kidney disease", 38th Annual Meeting of Indian Society of Nephrology Southern Chapter Conference, Feb 10, 2018, Hyderabad China. 2018. |
| Tang S.C.W., "Recent progress in the understanding of diabetic kidney injury", Symposium on autoimmune kidney diseases and renal pathology, June 21-24, 2018, Beijing China. 2018. |
| Tang S.C.W., "Role of HBcAb in ESRD and Renal Transplantation: Time to clear the confusion", 16th Asian Pacific Congress of Nephrology, Mar 31, 2018, Beijing China. 2018. |
| Tang S.C.W., "The Blossoming of PD in Hong Kong" Oct 5, 2017, British Columbia Kidney Days, Vancouver Canada. 2017. |
| Tang S.C.W., "Unmet Needs in Clinical trials of Diabetic Kidney Disease", 5th Brunei International Nephrology Conference, Apr 20, 2018, Brunei Darussalem. 2018. |
| Tang S.C.W., "Use of diabetic drugs in advanced kidney disease", Precourse in Diabetic Kidney Disease, 16th Asian Pacific Congress of Nephrology, Mar 28, 2018, Beijing China. 2018. |
| Tang S.C.W., In: American Society of Nephrology , Clinical Journal of the American Society of Nephrology (CJASN). American Society of Nephrology, 2017, 2017. |
| Tang S.C.W., Discussant and Co-chair in IgA Nephrology, KIDGO Glomerular Diseases Conference, Nov 19, 2017, Singapore. 2017. |
| Tang S.C.W., ERA-EDTA . European Nephrology Portal Dialogue Senior Editor, 2017, 2017. |
| Tang S.C.W., ESRD in South-East Asia. , In: Chronic kidney disease in disadvantaged populations, Edited by Guillermo Garcia-Garcia, Lawrence Agodoa, and Keith Norris, Elsevier . Academic Press, 2017, 2017: 149-156. |
| Tang S.C.W., Editor-in-Chief, appointed in 2018, Nephrology (Carlton), 2018, 2018. |
| Tang S.C.W., Editorial Advisory Board, appointed in 2018 (One of 7 international faculties in the same role), Seminars in Nephrology, 2018. |
| Tang S.C.W., Gout: A Disease of Kings, Contrib Nephrol. 2018, 2018: 192:77-81. |
| Tang S.C.W., Li P.K., Ng J.K., Cheng Y.L., Kwan T.H., Leung C.B., Lau M.F., Choi K.S., Fung S.K., Ho Y.W., Mak S.K., Wong K.S., Yong D. and Lui S.L., Hong Kong Society of Nephrology. Relatives in silent kidney disease screening (RISKS) study: A Chinese cohort study., Nephrology (Carlton). 2017, 2017. |
| Tang S.C.W., Lecture 1: “ESRD: epidemiology and treatment in developing countries in Southeast Asia”, Lecture 2: “Stem cell therapy for nephropathies” , The 7th Oriental Congress of Nephrology (OCN) cum ISN-GO CME course, Sep 9-10, 2017, Shanghai, China. 2017, 2017. |
| Tang S.C.W., Outstanding Research Award 2017, The University of Hong Kong. 2017. |
| Tang S.C.W., Viral Associated GN: Hep B / Hep C / other viruses (Mar 23, 2018) and Anti-GBM Disease (Mar 24, 2018)", Malaysian Society of Nephrology Annual Scientific Meeting, Kuala Lumpur, Malaysia. 2018. |
| Tang S.C.W., “How have recent trials informed the management of diabetic nephropathy?” , Chinese Society of Nephrology中华医学会肾脏病学分会2016年学术年会, Sep 15, 2017, Wuhan, China. 2017, 2017. |
| Tang S.C.W., “The Blossoming of PD in Hong Kong, British Columbia Kidney Days, Oct 5, 2017, Vancouver, Canada. 2017, 2017. |
| Tang S.C.W., “Treatment of diabetic kidney disease: landmark studies and tribulations”, 19th HK-Beijing Medical Exchange (co-organized by the Chinese Medical Association and the Hong Kong Medical Association), Sep 13, 2017, Wuhan, China. 2017, 2017. |
| Teo B.W., Zhang L., Guh J.Y., Jha V., Kang D.H., Tanchanco R., Hooi L.S., Praditpornshilpa K., Kong X., Zuo L., Chan G.C., Lee E.J.C. and Tang S.C.W., Glomerular Filtration Rates in Asians. , Adv Chronic Kidney Dis.. 2018, 2018: 25(1):41-48. |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Tang SOC |
| List of Research Outputs |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Researcher : Teo KC |
| List of Research Outputs |
| Pang S.Y.Y., HSU S.J., Teo K.C., LI Y., Kung M.H.W., Cheah K.S.E., Chan D., Cheung K.M.C., Li M., Sham P.C. and Ho S.L., Burden of rare variants in ALS genes influences survival in familial and sporadic ALS, Neurobiology of Aging. 2017, 58: 238.e9-238.e15. |
| Pang S.Y.Y., Teo K.C., Hsu J.S., Chang S.K.R., Li M., Sham P.C. and Ho S.L., The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review, Translational Neurodegeneration. United Kingdom, BioMed Central, 2017, 6: 27. |
| Researcher : Tong SM |
| List of Research Outputs |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Researcher : Tsang HLH |
| List of Research Outputs |
| Tsang H.L.H. and Chung H.Y., The Discriminative Values of the Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Spondyloarthritis-Related Axial Arthritis, JCR: Journal of Clinical Rheumatology. 2017, 23: 267-272. |
| Researcher : Tsang WHJ |
| Project Title: | Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population |
| Investigator(s): | Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 10/2008 |
| Project Title: | General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong. |
| Investigator(s): | Tsang WHJ, Yung ST, Lam WWT |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2011 |
| Project Title: | Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients |
| Investigator(s): | Tsang WHJ, Khoo US |
| Department: | Clinical Oncology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2012 |
| List of Research Outputs |
| Yeo W., Luk M.Y., Soong S.I., Yuen T.Y.S., Ng T.Y., Mo F.K.F., Chan K., Wong S.Y., Tsang W.H.J., Leung C., Suen J.J.S. and Ngan K.C.R., Efficacy and tolerability of trastuzumab emtansine in advanced human epidermal growth factor receptor 2–positive breast cancer, Hong Kong Medical Journal. 2018, 24(1): 55-62. |
| Researcher : Tse EWC |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Tse EWC |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | Provision of obinutuzumab (anti-CD20 monoclonal antibody) to elderly and/or unfit patients with chronic lymphocytic leukaemia |
| Investigator(s): | Tse EWC, Kwong YL, Chan SYT |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2017 |
| Completion Date: | 01/2018 |
| Project Title: | PTCL Study - PD-1 blockade with pembrolizumab in relapsed/refractory mature T-cell and NK-cell lymphomas |
| Investigator(s): | Tse EWC, Kwong YL, Singh GHH |
| Department: | Medicine |
| Source(s) of Funding: | Merck, Sharp and Dohme (Asia) Ltd. - General Award |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chan S.Y.T., Li J., Loong F., Khong P.L., Tse E.W.C. and Kwong Y.L., PD1 blockade with low-dose nivolumab in NK/T cell lymphoma failing l-asparaginase: efficacy and safety, Annals of Hematology. 2017. |
| Cheng C.W., LEONG K.W., NG Y.M., Kwong Y.L. and Tse E.W.C., The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27, Journal of Biological Chemistry. 2017, 292: 21431-21441. |
| Kharfan-Dabaja M.A., Kumar A., Ayala E., Hamadani M., Reimer P., Gisselbrecht C., d'Amore F., Jantunen E., Ishida T., Bazarbachi A., Foss F., Advani R., Fenske T.S., Lazarus H.M., Friedberg J.W., Aljurf M., Sokol L., Tobinai K., Tse E.W.C., Burns L.J., Chavez J.C., Reddy N.M., Suzuki R., Ahmed S., Nademanee A., Mohyt M., Gopal A.K., Fanale M.A., Pro B., Moskowitz A.J., Sureda A., Perales M.A., Carpenter P.A. and Savani B.N., Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation, Biology of Blood and Marrow Transplantation. 2017, 23: 1826-1838. |
| Reddy A., Zhang J., Davis N.S., Moffitt A.B., Love C.L., Waldrop A., Leppa S., Pasanen A., Meriranta L., Karjalainen-Lindsberg M.L., Nørgaard P., Pedersen M., Gang A.O., Høgdall E., Heavican T.B., Lone W., iqbal J., Qin Q., Li G., Kim S.Y., Healy J., Richards K.L., Fedoriw Y., Bernal-Mizrachi L., Koff J.L., Staton A.D., Flowers C.R., Paltiel O., Goldschmidt N., Calaminici M., Clear A., Gribben J., Nguyen E., Czader M.B., Ondrejka S.L., Collie A., Hsi E.D., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Choi W.L., Evens A.M., Pilichowska M., Sengar M., Reddy N., Li S., Chadburn A., Gordon L.I., Jaffe E.S., Levy S., Rempel R., Tzeng T., Happ L.E., Dave T., Rajagopalan D., Datta J., dunson D.B. and Dave S.S., Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma, Cell. 2017, 171: 481-494.e15. |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Researcher : Tse HF |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure |
| Investigator(s): | Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan HWF, Lam L, Lee KLF, Chan WS, Lam YM |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2009 |
| Project Title: | Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform |
| Investigator(s): | Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2012 |
| Completion Date: | 12/2018 |
| Project Title: | Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management |
| Investigator(s): | Tse HF, Siu DCW, Lai KWH |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 12/2014 |
| Project Title: | Discovery of New Approaches for Treating Hyperlipidemia Using an Induced Pluripotent Stem Cell (iPSC)-Based Platform |
| Investigator(s): | Tse HF, Esteban MA, Siu DCW, Lian Q |
| Department: | Medicine |
| Source(s) of Funding: | CAS - Croucher Funding Scheme for Joint Laboratories |
| Start Date: | 10/2016 |
| Project Title: | Sudden Unexpected Death (SUD) in Hong Kong |
| Investigator(s): | Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Sun Chieh Yeh Heart Foundation - General Award |
| Start Date: | 06/2017 |
| List of Research Outputs |
| CHEN L., Cui Y., Jiang D., MA C.Y., Jiang D., Hwu W.L., Lian Q. and Tse H.F., Management of Leigh syndrome: Current status and new insights, Clinical Genetics. 2018, 93: 1131-1140. |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| CHENG Y., Li X.C., Tse H.F. and Rong J., Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-14. |
| Chan Y.H. and Tse H.F., Embolic Origin of Osler Nodes, Mayo Clinic Proc 2017. 2017, 92(9): 1459-1460. |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Chan Y.H., Lam C.C.S. and Tse H.F., Monozygotic twins with coronary artery ectasia, European Heart Journal - Cardiovascular Imaging. 2018, 19: 471-472. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Dagres N., Chao T.F., Fenelon G., Aguinaga L., Benhayon D., Benjamin E.J., Bunch T.J., Chen L.Y., Chen S.A., Darrieux F., de Paola A., Fauchier L., Goette A., Kalman J., Kalra L., Kim Y.H., Lane D.A., Lip G.Y.H., Lubitz S.A., Marquez M.F., Potpara T., Pozzer D.L., Ruskin J.N., Savelieva I., Teo W.S., Tse H.F., Verma A., Zhang S., Chung M.K., Bautista-Vargas W.F., Chiang C.E., Cuesta A., Dan G.A., Frankel D.S., Guo Y., Hatala R., Lee Y.S., Murakawa Y., Pellegrini C.N., Pinho C., Milan D.J., Morin D.P., Nadalin E., Ntaios G., Prabhu M.A., Proietti M., Rivard L., Valentino M. and Shantsila A., European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on arrhythmias and cognitive function: What is the best practice?, J Arrhythm. 2018. 2018, 34(2): 99-123. |
| Ding Y., Liang X., Zhang Y.L., Yi L., Shum H.C., Chen Q., Chan B.P., Fan H.M., Liu Z.M., Tergaonkar V., Qi Z.Q., Tse H.F. and Lian Q., Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation, Cell Death & Disease. 2018, 9. |
| Gorenek B C.H.A.I.R., Bax J., Boriani G., Chen S.A., Dagres N., Glotzer T.V., Healey J.S., Israel C.W., Kudaiberdieva G., Levin L.A., Lip G.Y.H., Martin D., Okumura K., Svendsen J.H., Tse H.F. and Botto G.L., Device-detected subclinical atrial tachyarrhythmias: definition, implications and management-an European Heart Rhythm Association (EHRA) consensus document, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE)., Europace.. 2017, 19(9): 1556-1578. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Hai S.H.J.J. and Tse H.F., Myths and legends of right ventricular septal pacing, Journal of Cardiovascular Electrophysiology. 2017. |
| Hai S.H.J.J., Un K.C., Wong C.K., Wong K.L., Zhang Z.Y., Chan P.H.M., Lau C.P., Siu D.C.W. and Tse H.F., Prognostic implications of early monomorphic and non–monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome, Heart Rhythm. 2018, 15: 822-829. |
| Lai P.L., Lau C.S.T., Wong K.L., Gui H., WANG X., ZHOU T., Lai K.W.H., Tse H.F., Tam P.K.H., Garcia-Barcelo M.M. and Ngan E.S.W., Correction of Hirschsprung-associated mutations in human induced pluripotent stem cells via clustered regularly interspaced short palindromic repeats/Cas9, restores neural crest cell function, Gastroenterology. 2017, 153(1): 139-153. |
| Lau C.P. and Tse H.F., An Unpleasant Legacy, JACC: Clinical Electrophysiology. 2018, 4: 209-211. |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Liao S. and Tse H.F., Potent Immunomodulation and Angiogenic Effects of Mesenchymal Stem Cells versus Cardiomyocytes Derived from Pluripotent Stem Cells for Treatment of Heart Failure, ISSCR Annual Meeting 2018. 2018. |
| Liu F.Z., Liao H.T., Lin W.D., Xue Y.M., Zhan X.Z., Rao F., Deng H., Huang J., Hai S.H.J.J., Tse H.F. and Wu S.L., Predictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients, International Journal of Cardiology. 2018, 258: 103-108. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Lu J., Lee Y.K., Ran X., Lai K.W.H., Keung W.W.Y., Tse W.W., Tse H.F. and Yao X., An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. , Biochimica et biophysica acta . 2017. |
| Lu X., Peloso G.M., Liu D.J., Wu Y., Zhang H., Zhou W., Li J., Tang S.M., Dorajoo R., LI H., Long J., Guo X., Xu M., Spracklen C.N., Chen Y., Liu X., Zhang Y., Khor C.C., Liu J., Sun L., Wang L., Gao Y., Hu Y., Yu K., Wang Y., Cheung Y.Y., Wang F., Huang J., Fan Q., Cai Q., Chen S., Shi J., Yang X., Zhao W., Sheu W.H., Cherny S.S., He M., Feranil A.B., Adair L.S., Gordon-Larsen P., Du S., Du R., Chen Y.I., Shu X., Lam K.S.L., Wong T.Y., Ganesh S.K., Mo Z., Hveem K., Fritsche L.G., Nielsen J.B., Tse H.F., Huo Y., Cheng C., Chen Y.E., Zheng W., Tai E.S., Gao W., Lin X., Huang W., Abecasis G., Kathiresan S., Mohlke K.L., Wu T., Sham P.C., Gu D. and Willer C.J., Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease, Nature Genetics. 2017, 49: 1722-1730. |
| Mak S.H.T., Lee Y.K., Tang S.M., Hai S.H.J.J., Ran X., Sham P.C. and Tse H.F., Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy., Scientific Reports. 2018, 8: 10846. |
| Mura M..., Lee Y.K., Ginevrino M., Zappatore R., Dagradi F., Crotti L., Valente E.M., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene., Stem Cell Research . 2018, 29: 157-161. |
| Tanabe Y., Liao S., Zhen Z. and Tse H.F., High-performance wireless powering for peripheral nerve neuromodulation systems, PLOS ONE. 2017, 12: e0186698. |
| Tse H.F., Chair The 10th Asia Pacific Heart Rhythm Society session, Yokohama, Japan Circadian rhythm/autonomic nervous system and arrhythmias, 2017. |
| Tse H.F., Chair,2nd Global Scientific Summit, Lisbon, Portugal “Case Discussion”, 2018. |
| Tse H.F., Chair: Asian Pacific Society of Cardiology Congress, Taipei, Taiwan Molecular Diagnosis in Cardiovascular Disease, 2018. |
| Tse H.F., Chairperson, 2018, ACS Conference treatment in Hong Kong , 2018. |
| Tse H.F., Invited Speaker, Asian Pacific Society of Cardiology Congress, Taipei, Taiwan Molecular Diagnosis in Cardiac Arrhythmia - focus on AF, 2018. |
| Tse H.F., Invited Speaker, American heart Association Scientific Session 2016, New Orleans, Untied States, “Cardiovascular Risk Models, Risk Scores, and Risk Stratifying Tools”, 2017. |
| Tse H.F., Invited Speaker, Oriental Congress of Cardiology 2018, Shanghai, China Latest advances in CIED Without transvenous leads High density mapping and ablation in patients with complex congenital heart diseases, 2018. |
| Tse H.F., Invited Speaker, European Cardiology Congress 2017, Barcelona, Spain “Does subclinical atrial tachyarrhythmia matter in terms of prognosis?”, european Cardiology Congress 2017, Barcelona, Spain. 2017. |
| Tse H.F., Invited Speaker, European Society Congress 2017, Barcelona, Spain “Does subclinical atrial tachyarrhythmia matter in terms of prognosis?”, 2017. |
| Tse H.F., Invited Speaker, Macau Rehabilitation Association 2016, Macau, “"Sports Injuries: Prevention and Treatment", 2017. |
| Tse H.F., Invited Speaker, The 10th Asia Pacific Heart Rhythm Society session, Yokohama, Japan “The safety and feasibility of S-ICD in an Asian population, “ “S-ICD in patient with structural heart disease, 2017. |
| Tse H.F., Invited Speaker, The 9th Guangzhou International Conference on Stem Cell and Regenerative Medicine,Guangzhou, China “Human pluripotent stem cells derived mesenchymal stem cells as novel therapy for treatment of cardiovascular diseases”, 2017. |
| Tse H.F., Invited Speaker, XVII International Symposium, Rome Italy Presentation: Spinal Cord stimulation, 2017. |
| Tse H.F., Invited Speaker, ““The safety and feasibility of S-ICD in an Asian population, “ “S-ICD in patient with structural heart disease", The 10th Asia Pacific Heart Rhythm Society session, Yokohama, Japan. 2017. |
| Tse H.F., Invited Speaker,2nd Global Scientific Summit,Lisbon Portugal”AF Patient s of Asian Origin, 2018. |
| Tse H.F., Invited Speaker,CHCSJ Cardiology Lecture, Macau, What is the latest update on PCSK9 inhibitors, 2018. |
| Tse H.F., Invited Speaker,Cardiology Assocation Expert Symposium, Macau” Antithrombotic strategies post- PCI: What do we know so far?, 2017. |
| Tse H.F., Invited Speaker,Heart Rhythm Sessions, Boston, United States Improving disease awareness and diagnosis of AF in a Joint Session entitled Fighting Against the Global Burden of Stroke and AF, 2018. |
| Tse H.F., Invited Speaker,Heart Rhythm Sessions, Boston, United States 2018 Improving disease awareness and diagnosis of AF in a Joint Session entitled Fighting Against the Global Burden of Stroke and AF, 2018. |
| Tse H.F., Invited Speaker,MACI Symposium, Macau,” 新指引產的背景和意義”, 2018. |
| Tse H.F., Invited Speaker,Mexico Masterclass 2018, Mexico,” Late Breaking from ACC 2018”, 2018. |
| Tse H.F., Invited Speaker,VAS China 2018, Nanjing, China”Subcutaneous ICD Implanation: current status and future directions.”, 2018. |
| WANG Y., ZHEN Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., A case-control study on periodontitis and left ventricular function in patients with diabetes, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD156. |
| WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Pelekos G., Tonetti M. and Jin L., Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients, Journal of Clinical Periodontology. 2017, 44: 1253-1263. |
| Wong C.X., Brown A., Tse H.F., Albert C.M., Kalman J.M., Marwick T.H., Lau D.H. and Sanders P., Epidemiology of Atrial Fibrillation: The Australian and Asia-Pacific Perspective., Heart Lung Circulation 2017. 2017, 26(9): 870-879. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu K.H., Chen Y., Liu J.H., Lin Q., Liu M., Wu M., Wang R., Zhen Z., Zou Y., Lam Y.M., Ng M.Y., Lau C.P. and Tse H.F., Burden and contributing factors associated with tricuspid regurgitation: a hospital-based study, Hospital Practice. 2017. |
| Yiu K.H. and Tse H.F., Editorial commentary: Heart failure in systemic lupus erythematosus: A problem to address, Trends in Cardiovascular Medicine. 2018, 28: 198-199. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| ZHANG Z., Zhang Y., Gao F., HAN S., Cheah K.S.E., Tse H.F. and Lian Q., CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects, Molecular Therapy - Nucleic Acids. 2017, 9: 230-241. |
| Zhuang Q., Li W.J., Benda C., Huang Z.J., Ahmed T., Liu P., Guo X.P., Ibanez D.P., Luo Z., Zhang M., Abdul M.M., Yang Z.Z., YANG J., Huang Y., Zhang H., Huang D., Zhou J., Zhong X., Zhu X., Fu W., Fan W., Liu Y., Xu Y., Ward C., Khan M.J., Kanwal S., Mirza B., Tortorella M.D., Tse H.F., Chen J., Qin B., Bao X., Gao S., Hutchins A.P. and Esteban M.A., NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming, Nature Cell Biology. 2018, 20: 400-412. |
| Zhuang Q., Li W., Benda C., Huang Z., Ahmed T., Liu P., Guo X., Ibanez D.P., Luo Z., Zhang M., Abdul M.M., Yang Z., Yang J., Huang Y., Zhang H., Huang D., Zhou J., Zhong X., Zhu X., Fu X., Fan W., Liu Y., Xu Y., Ward C., Khan M.J., Kanwal S., Mirza B., Tortorella M.D., Tse H.F., Chen J., Qin B., Bao X., Gao S., Hutchins A.P. and Esteban M.A., Publisher Correction: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming., Nat Cell Biol. 2018. |
| Researcher : Tse MYM |
| List of Research Outputs |
| Kwan S.K.J., Tse M.Y.M. and Li L.S.W., Neurological Rehabilitation, Oxford Textbook of Geriatric Medicine (Third Edition). Oxford University Press, 2017. |
| Teo K.C., Lau G.K.K., Mak R.H.Y., Leung H.Y., Chang S.K.R., Tse M.Y.M., Lee R., Leung G.K.K., Ho S.L., Cheung R.T.F., Siu D.C.W. and Chan K.H., Antiplatelet resumption after antiplatelet-related intracerebral hemorrhage: a retrospective hospital-based study, World Neurosurgery. 2017, 106:85-91. |
| Tsang C.O.A., Yeung R.W.L., Tse M.Y.M., Lee R. and Lui W.M., Emergency thrombectomy for acute ischaemic stroke: current evidence, international guidelines and local clinical practice, Hong Kong Medical Journal. 2018, 24(1): 73-80. |
| Tsang C.O.A. and Tse M.Y.M., Endovascular mechanical thrombectomy for acute ischemic stroke: new developments in 2018., CME Bulletin. 2018. |
| Researcher : Tso AWK |
| Project Title: | A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer |
| Investigator(s): | Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS |
| Department: | Medicine |
| Source(s) of Funding: | Health and Health Services Research Fund - Full Grants |
| Start Date: | 12/2008 |
| Project Title: | Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ? |
| Investigator(s): | Tso AWK, Lam KSL, Chan DTM, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2009 |
| List of Research Outputs |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Researcher : WANG Y |
| List of Research Outputs |
| WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-13. |
| Researcher : Wang AYM |
| Project Title: | An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease |
| Investigator(s): | Wang AYM, Kwan CW, Lai KN |
| Department: | Medicine |
| Source(s) of Funding: | Health and Health Services Research Fund - Full Grants |
| Start Date: | 07/2008 |
| Project Title: | Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs |
| Investigator(s): | Wang AYM |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2010 |
| Researcher : Wang B |
| List of Research Outputs |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018. |
| Pan X., Shao Y., Wu F., Wang Y., Xiong R., Zheng J., Tian H., Wang B., Wang Y., Zhang Y., Han Z., Qu A., Xu H., Lu A., Yang T., Li X., Xu A., Du J. and Lin Z., FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice, Cell Metabolism. 2018, 27. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Wu K., Yau S., Xu A. and Cheng K., Ablation of the adaptor protein APPL2 in hypothalamic RIP-Cre neurons by promotes beiging of WAT via sympathetic nervous system, 2017 Singapore Symposium on Metabolic Diseases. 2017. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Liu Z., Wu K., Yau S., Xu A. and Cheng K., Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system, EMBO reports. 2018, 19: e44977. |
| Researcher : Wang J |
| Project Title: | Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers |
| Investigator(s): | Wang J, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2008 |
| Project Title: | Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells |
| Investigator(s): | Wang J, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2009 |
| Researcher : Wang J. |
| Project Title: | Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers |
| Investigator(s): | Wang J, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2008 |
| Project Title: | Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells |
| Investigator(s): | Wang J, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2009 |
| Researcher : Wong B.C.Y. |
| Project Title: | Effect of XAF1 gene on tumor growth in gastric and colon cancer |
| Investigator(s): | Wong CYB, Tu S |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2003 |
| Project Title: | Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer |
| Investigator(s): | Wong CYB, Xia HHX |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2004 |
| Researcher : Wong BCY |
| Project Title: | Effect of XAF1 gene on tumor growth in gastric and colon cancer |
| Investigator(s): | Wong CYB, Tu S |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2003 |
| Project Title: | Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer |
| Investigator(s): | Wong CYB, Xia HHX |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2004 |
| Researcher : Wong CM |
| Project Title: | Coupling of nuclear RNA surveillance with splicing |
| Investigator(s): | Wong CM, Chen C |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| Researcher : Wong DKH |
| Project Title: | Proteomic profiling of proteins associated with spontaneous hepatitis B surface antigen seroclearance |
| Investigator(s): | Wong DKH, Yuen RMF, Seto WKW, Pang HMH, Huang FY |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2017 |
| Completion Date: | 11/2017 |
| List of Research Outputs |
| Buter E.K., Wong D.K.H., Jackson K., Schluep T., Gersch J., Kuhns M., Cloherty G.A., Locarnini S. and Yuen R.M.F., Utility of a new HBV RNA assay in HBeAg positive and negative CHB and following HBsAg seroclearance in patients treated with ARC‐520, an RNAi drug targeting cccDNA derived HBV mRNA, 16th International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD) held from June 14th to 17th, 2018, in Toronto, Canada. Journal of Viral Hepatitis. 2018, 25(2): 190-191. |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Locarnini S., Wong D.K.H., Jackson K., Walsh R., Edwards R., Hammond R., Macfarlane C., Iyer R.P., Afdhal N.H. and Yuen R.M.F., Novel anti-viral activity of SB 9200, a RIGI agonist; results from Cohort 1 of the ACHIEVE trial, Hepatology. 2017, 66(6): 1269A-1270A. |
| Macfarlane C., Locarnini S., Jackson K., Walsh R., Edwards R., Hammond R., Coffin C., Elkhashab M., Greenbloom S., Ramji A., Chan H.L.Y., Afdhal W., Kim N., Afdhal N., Yuen R.M.F., Wong D.K.H. and Lyer R., Inarigivir: a novel RIG-I agonist for chronic hepatitis B, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S264. |
| Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Hepatitis B core protein as a therapeutic target, Expert Opinion on Therapeutic Targets. 2017, 21: 1153-1159. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, Alimentary Pharmacology & Therapeutics. 2018, 47: 43-54. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection, Clinical and Translational Gastroenterology. 2018, 9: 163. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Wong D.K.H., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Occult hepatitis B infection in hepatocellular carcinoma patients with negative HBsAg, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S474. |
| Wong D.K.H., Recent Study on Assessment of Liver Fibrosis Stages, 有關評估肝纖維化的最新研究, Macau Institute of Medical Laboratory Sciences and Associação de Técnicos de Diagnóstico e Terapêutica de Macau Annual Meeting and Seminar. 澳門診療技術員協會 澳門醫務檢驗學會 會員大會 暨 專題會議 , 2017. |
| Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018. |
| Researcher : Wong LC |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Researcher : Wong LY |
| List of Research Outputs |
| Lee Y.K., Lau V.Y.M., Cai Z., Lai K.W.H., Wong L.Y., Tse H.F., Ng K.M. and Siu D.C.W., Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells., J Am Heart Assoc. 2017. 2017, 6: 1-36. |
| Researcher : Wong LYF |
| Project Title: | Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages |
| Investigator(s): | Wong LYF, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications |
| Investigator(s): | Wong LYF, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2006 |
| Researcher : Wong SY |
| List of Research Outputs |
| Leung W.K., But Y.K.D., Wong S.Y., Tong S.M., Liu S.H.K., Cheung K.S.M., Tsang H.Y.S., Chok K.S.H., Poon R.T.P. and Hung F.N.I., Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial, Journal of Digestive Diseases. 2018. |
| Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3. |
| Researcher : Wong WLD |
| List of Research Outputs |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Wong Y |
| List of Research Outputs |
| Shiu S.W.M., Wong Y. and Tan K.C.B., Pre-β1 HDL in type 2 diabetes mellitus., Atherosclerosis.. 2017, 263: 24-28. |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219. |
| Tan K.C.B., Shiu S.W.M., Lam K.Y.J., Lee C.H.A. and Wong Y., Serum galectin-3 and all-cause mortality in type 2 diabetes., American Diabetes Association 78th Scientific Sessions, Orlando, USA.. 2018. |
| Tan K.C.B., Shiu S.W.M. and Wong Y., Serum galectin-3 predicts progressive kidney disease in type 2 diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon,.. 2017. |
| Researcher : Wong YK |
| List of Research Outputs |
| Lau G.K.K., Wong Y.K., Teo K.C., Chang R.S.K., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Kwan S.K.J., Hui S.K. and Mak H.K.F., Long-term prognostic implications of cerebral microbleeds in Chinese with ischaemic stroke, Journal of the American Heart Association. 2017. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C.T.V., Chan Q. and Hui S.K., Prognostication of stroke recovery using structural connectivity, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 4821. |
| XU X., Lau G.K.K., Li L.S.W., Wong Y.K., Yau C., Mak H.K.F., Chan Q. and Hui S.K., The effect of small vessel disease lesions on structural brain network, The 25th Annual Meeting of ISMRM, Paris, France. 2018, 1907. |
| XU X., Lau G.K.K., Wong Y.K., Mak H.K.F. and Hui S.K., The effect of the total small vessel disease burden on the structural brain network, Scientific Reports. 2018, 8: 7442. |
| Researcher : Wong YYS |
| List of Research Outputs |
| Zhang H., Lam K.H., Lam W.W.L., Wong Y.Y.S., Chan V.S.F. and Au S.W.N., A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori, Molecular Microbiology. 2017. |
| Researcher : Woo YC |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Lang H.H.B., Woo Y.C. and Chiu W.H.K., Evaluation of pain during high-intensity focused ultrasound ablation of benign thyroid nodules, European Radiology. 2018, Epub ahead of print. |
| Lang H.H.B., Woo Y.C. and Chiu W.H.K., Significance of hyperechoic marks observed during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules, European Radiology. 2018, Epub ahead of print. |
| Lang H.H.B., Woo Y.C., Wong Y.H.I. and Chiu W.H.K., Single-session high-intensity focused ultrasound treatment for persistent or relapsed Graves Disease: preliminary exerpeince in a prospective study, Radiology. 2017, Epub ahead of print. |
| Lang H.H.B., Woo Y.C. and Chiu W.H.K., The percentage of serum thyroglobulin rise in the first-week did not predict the eventual success of high-intensity focussed ablation (HIFU) for benign thyroid nodules, International Journal of Hyperthermia. 2017, Epub ahead of print. |
| Lang H.H.B., Woo Y.C. and Chiu W.H.K., Two-year efficacy of single-session high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules, European Radiology. 2018, Epub ahead of print. |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Wong C.K.H., Choi P.H., Woo Y.C. and Lang H.H.B., Measurement properties of ThyPRO short-form (ThyPRO-39) for use in Chinese patients with benign thyroid diseases, Quality of Life Research. 2018. |
| Woo Y.C., Lee C.H.P., Fong H.Y., Tso A.W.K., Cheung B.M.Y., Lam K.S.L. and Hu C., Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population, PLOS ONE. 2017, 12: e0184840. |
| Researcher : Wu CH |
| List of Research Outputs |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Researcher : Wu H |
| List of Research Outputs |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Researcher : XU P |
| List of Research Outputs |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., American Thoracic Society International Trainee Scholarship Award 2018 & American Thoracic Society-International Society for Respiratory Diseases Travel Award 2018, American Thoracic Society & American Thoracic Society-International Society for Respiratory Diseases, Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diabetes risk in a Chinese cohert. 2018, 197: A7696. |
| XU P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Long-term continuous positive airway pressure treatment for obstructive sleep apnea reduces incident diebetes risk in a Chinese cohert, American Thoracic Society International Conference, San Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A7696. |
| XU P., Lui M.S.M., Lam C.L.D., Ip M.S.M., Fong D.Y.T. and Hui K.M.C., Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population., European Respiratory Society International Congress 2017, Milan Italy, Sep 2017, European Respiratory Journal. 2017, 50 (Suppl 61): PA 1185. |
| Researcher : XU S |
| List of Research Outputs |
| Ho J.C.M., XU S., Cheng P.N. and Lam S.K., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , American Society of Clinical Oncology. 2018. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models , IASLC 18th World Conference on Lung Cancer. 2017. |
| Lam S.K., XU S., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models, 23rd Medical Research Conference. 2018, 24: 34. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, 23rd Medical Research Conference. 2018, 2: 59. |
| XU S., Lam S.K., Cheng P.N. and Ho J.C.M., The Effects of Pegylated Arginase on Small Cell Lung Cancer in vitro and in vivo, IASLC 18th World Conference on Lung Cancer. 2017. |
| Researcher : Xia HHX |
| Project Title: | Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study |
| Investigator(s): | Xia HHX, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2003 |
| Project Title: | Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis |
| Investigator(s): | Xia HHX, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2004 |
| Project Title: | Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis |
| Investigator(s): | Xia HHX, Wong CYB |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2005 |
| Researcher : Xiong J |
| Project Title: | 2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF |
| Investigator(s): | Xiong J |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2008 |
| Researcher : Xu A |
| Project Title: | Molecular mechanism underlaying the pathogenesis of type 2 diabetes |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 05/2007 |
| Project Title: | Genetic and pathogenic pathways leading to type 2 diabetes Mellitus |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 05/2011 |
| Project Title: | 71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2011 |
| Project Title: | Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2013 |
| Project Title: | Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain |
| Investigator(s): | Xu A, Cheng KY |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance |
| Investigator(s): | Xu A, Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues |
| Investigator(s): | Xu A, Hui X |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes |
| Investigator(s): | Xu A, Lam KSL, Chan YCC |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications |
| Investigator(s): | Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L |
| Department: | Medicine |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 04/2015 |
| Project Title: | A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention |
| Investigator(s): | Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2015 |
| Project Title: | 2015 51st EASD Annual Meeting ; Adiponectin is required for adaptive thermogenesis by enhancing the browning of white adipose tissues in mice |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2015 |
| Project Title: | Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications |
| Investigator(s): | Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2015 |
| Project Title: | Frontiers in Immunometabolism |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 11/2015 |
| Project Title: | Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Brown adipose tissue as a new weapon against obesity-related vascular disorders |
| Investigator(s): | Xu A, Hui X |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Completion Date: | 04/2018 |
| Project Title: | Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism |
| Investigator(s): | Xu A, Woo WHC |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Project Title: | FGF21 as a potential mediator for the anti-depressant effects of physical exercise |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Project Title: | Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis |
| Investigator(s): | Xu A, Vanhoutte PMGR |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Project Title: | Fibroblast growth factor-21 as an Autocrine Regulator of Browning and Adaptive Thermogenesis in Subcutaneous Adipose Tissue |
| Investigator(s): | Xu A, Hui X |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Vascular Dysfunction in Obestiy and Diabetes: From Molecular Mechanism to Therapeutic Intervention |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2017 |
| Completion Date: | 01/2018 |
| Project Title: | Development of an Innovative Immunoturbidimetric Assay (ITA) of Lipocalin-2 (LCN2) for Prognosis and Diagnosis of Diabetes and its Cardiovascular Complications |
| Investigator(s): | Xu A, Zhong L, Zhou P |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2017 |
| Project Title: | Adiponectin antagonizes dietary obesity-induced metabolic dysfunction via modulation of gut microbiota |
| Investigator(s): | Xu A, Liu Y |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | Institute of Metabolic Medicine (AoE) |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2017 |
| Project Title: | A multi-disciplinary study on the beneficial effects of PPARD in physical exercise against diabetic vascular complications: cellular crosstalk and energy metabolism |
| Investigator(s): | Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2017 |
| Project Title: | UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy |
| Investigator(s): | Xu A, Hui X |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | The mechanobiology of obesity |
| Investigator(s): | Xu A, Hui X, Wang B |
| Department: | Medicine |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2018 |
| Project Title: | A Multi-Channel Oxytherm System for Research into Mitochondria Respiration and Function |
| Investigator(s): | Xu A, Shen J, Chung SK, Hoo RLC, Hui X, Woo WHC |
| Department: | Medicine |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2018 |
| Project Title: | Hepatic G protein-coupled receptor 110 as a potential therapeutic target to combat obesity and its related metabolic complications |
| Investigator(s): | Xu A, Huang Z |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Conversion of white into brown adipocytes as a therapeutic strategy for obesity-related metabolic and vascular complications |
| Investigator(s): | Xu A, Hoo RLC, Hui X, Vanhoutte PMGR, Wang Y, Woo WHC |
| Department: | Medicine |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors, Acta Pharmacologica Sinica. 2017, 38: 1699-1700. |
| CHEN X., Xu A. and Tang E.H.C., Deletion of Rap1 promotes macrophage infil-tration and foam cell formation during athero-sclerosis, IVBM2018, 3-7 Jun 2018, Helsinki, Finland. 2018. |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018. |
| Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10. |
| Cheung K.L.A., Kwok H.Y., Huang Y., Chen M., Mo Y., WU X., LAM K.S., Kong H., Lau T...C...K..., ZHOU J., Li J., Cheng L., LEE B.K., Peng Q., Lu X., An M., Wang H., Shang H., Zhou B., Wu H., Xu A., Yuen K.Y. and Chen Z., Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection, In: Andrew Jermy Nonia Pariente, Nature Microbiology. 2017. |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Duan L., Wei L., Tian Y., Zhang Z., Hu P., Wei Q., Liu S., Zhang J., Wang Y., Li D., Yang W., Zong R., Xian P., Han C., Bao X., Zhao F., Feng J., Liu W., Cao W., Zhou G., Zhu C., Yu F., Yang W., Meng Y., Wang J., Chen X., Wang Y., Shen B., Zhao B., Wan J., Zhang F., Zhao G., Xu A., Zhang X., Liu J., Zuo X. and Wang K., Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study, Stroke. 2018, 49: 11-18. |
| Gao C., Du Q., LI W., Deng R., Wang Q., Xu A. and Shen J., Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression, Molecular Neurobiology. 2018. |
| Hoo R.L.C., Pan Y., Shu L., Lam K.S.L. and Xu A., Adipocyte Fatty Acid Binding Protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11-15 Sep 2017, Lisbon. 2017. |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| JI X., Zhou P., Zhong L., Xu A., Tsang C.O.A. and Chan K.L., Smart surgical catheter for C-reactive protein sensing based on an imperceptible organic transistor, Advanced Science. 2018, Epub on 2018-05-03. |
| LIAO B., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein mediates ischemic stroke, Mini-symposium on brain and adipose tissue crosstalk 2017. 2017. |
| Li J., Woo W.H.C. and Xu A., Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota, Keystone Symposia: Manipulation of the Gut Microbiota for Metabolic Health. 2018. |
| NG K.K., Lee C.H.P., Woo Y.C., Chow W.S., Wong L.C., Fong H.Y., Xu A., Sham P.C., Lam K.S.L. and Cheung Y.Y., Validation of association signals identified from genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Nie T., Zhao S., Mao L., Yang Y., Sun W., Lin X., Liu S., Li K., Sun Y., Li P., Zhou Z., Lin S., Hui X., Xu A., Ma C.W., Xu Y., Wang C., Dunbar P.R. and Wu D., The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity , British Journal of Pharmacology. 2018, 175: 1439-1450. |
| Ong K., O'Connell R., Januszewski, A., Jenkins A., Xu A., Sullivan D., Barter P., Scott R., Taskinen M., Waldman B., Colman P., Best J., Simes J. and Rye K., Keech A., Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study, Clinical Chemistry. 2017, 63: 1261-1270. |
| Pan X., Shao Y., Wu F., Wang Y., Xiong R., Zheng J., Tian H., Wang B., Wang Y., Zhang Y., Han Z., Qu A., Xu H., Lu A., Yang T., Li X., Xu A., Du J. and Lin Z., FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice, Cell Metabolism. 2018, 27. |
| Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018. |
| Shu L., Zhong L., Xiao Y., Hoo R.L.C. and Xu A., Pharmacological Inhibition of Neutrophil Elastase Attenuates Insulitis &Autoimmune Diabetes in Mice , American Diabetes Association 78th Scientific sessions . 2018. |
| WANG Y., Mak J.C.W., Lee Y.K.M., Xu A. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-13. |
| WU C., Xu A., Zhang C.C., Olson P., Chen L., Lee T.K., Cheung T.T., Lo C.M. and Wang X., Notch inhibitor PF-03084014 inhibits hepatocellular carcinoma growth and metastasis via suppression of cancer stemness due to reduced activation of Notch1-Stat3, Molecular Cancer Therapeutics. 2017, 16(8): 1531-1543. |
| WU X., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., The Role of Adipocyte Fatty Acid Binding Protein in the Development of Liver Fibrosis, American Diabetes Association 78th Scientific Sessions, 22-26 Jun 2018, Orlando, FL. 2018. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Wu K., Yau S., Xu A. and Cheng K., Ablation of the adaptor protein APPL2 in hypothalamic RIP-Cre neurons by promotes beiging of WAT via sympathetic nervous system, 2017 Singapore Symposium on Metabolic Diseases. 2017. |
| Wang B., Li A., Li X., Ho W.L., Wu D., Wang X., Liu Z., Wu K., Yau S., Xu A. and Cheng K., Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system, EMBO reports. 2018, 19: e44977. |
| Woo W.H.C., Xu A. and Li J., Faculty Research Output Prize, Li Ka Shing Faculty of Medicine, HKU. 2017. |
| YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Maternal-Fetal Crosstalk: Harmony vs. Conflict, 4-8 Oct 2017, Westin Washington, DC City Center, Washington, DC, USA. 2017. |
| Yan C.H., ZHANG C., Chiu P.K.Y. and Xu A., Gold medal, 2017 International Invention Innovation Competition in Canada, Toronto International Society of Innovation & Advanced skills. 2017. |
| Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018. |
| ZHANG C., Yan C.H., Chiu P.K.Y. and Xu A., Alice L. Jee Young Investigator Award, Orthopaedic Research Society . 2017. |
| ZHANG C., Chiu P.K.Y., Lu W.W., Xu A. and Yan C.H., Best paper for associate member, Hong Kong Orthopaedic Association. 2017. |
| ZHANG C., Yan C.H., Chiu P.K.Y. and Xu A., Blue Ribbon Poster Award, Orthopaedic Research Society. 2017. |
| ZHANG C., LI T., Chiu P.K.Y., Wen C., Xu A. and Yan C.H., FABP4 as a biomarker for knee osteoarthritis, Biomarkers in Medicine. 2018. |
| ZHANG C., Chiu P.K.Y., Xu A. and Yan C.H., Fatty Acid Binding Protein 4 (FABP-4) as A Biomarker for Osteoarthritis, 37th Hong Kong Orthopaedic Association Annual Congress. 2017. |
| ZHANG C., Chiu P.K.Y., Xu A. and Yan C.H., Fatty Acid Binding Protein 4 (FABP-4) as A Biomarker for Osteoarthritis, Orthopaedic Research Society (ORS) 47th International Musculoskeletal Biology Workshop. 2017. |
| ZHANG C., Chiu P.K.Y., CHAN P.M.B., LI T., Wen C., Xu A. and Yan C.H., Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice, Osteoarthritis & Cartilage. 2018, 6: 824-833. |
| ZHOU Y., CHENG K.K.Y., Xu A. and Hoo R.L.C., Metabolic Profiling of Serum Reveals Significant Changes in Lipid and Amino Acid Metabolism in a Lipodystrophy Mouse Model, EXPERIMENTAL BIOLOGY 2018, 21-25 Apr 2018, San Diego, California. 2018. |
| Zhang F., Hu Z., Li G., Huo S., Ma F., Cui A., Xue Y., Han Y., Gong Q., Gao J., Bian H., Meng Z., Wu H., Long G., Tan Y., Zhang Y., Lin X., Gao X., Xu A. and Li Y., Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice, Hepatology. 2018. |
| Zhang J., Li H., Zhou H., Fang L., Xu J., Yan H., Chen S., Song Q., Zhang Y., Xu A., Fang Q., Ye Y. and Jia W., Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose, Scientific Reports. 2017, 7. |
| Zhu C.F., Zhang W., Mu B., Zhang F., Lai N.N., Zhou J.X., Xu A., Liu J.G. and Li Y., Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats, Journal of Food Science and Technology. 2017, 54: 2260-2269. |
| Zhu C.F., Zhang W., Liu J.G., Mu B., zhang F., Lai N.N., Zhou J.X., Xu A. and Li Y., Marine Collagen Peptides Reduce Endothelial Cell Injury In Diabetic Rats By Inhibiting Apoptosis And The Expression Of Coupling Factor 6 And Microparticles, Molecular Medicine Reports. 2017, 16: 3947-3957. |
| Researcher : YANG J |
| List of Research Outputs |
| Zhuang Q., Li W.J., Benda C., Huang Z.J., Ahmed T., Liu P., Guo X.P., Ibanez D.P., Luo Z., Zhang M., Abdul M.M., Yang Z.Z., YANG J., Huang Y., Zhang H., Huang D., Zhou J., Zhong X., Zhu X., Fu W., Fan W., Liu Y., Xu Y., Ward C., Khan M.J., Kanwal S., Mirza B., Tortorella M.D., Tse H.F., Chen J., Qin B., Bao X., Gao S., Hutchins A.P. and Esteban M.A., NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming, Nature Cell Biology. 2018, 20: 400-412. |
| Researcher : YU H |
| List of Research Outputs |
| YU H., Gao J., Chang S.K.R., Mak W. and Cheung R.T.F., Cognitive impairments in chronic temporal lobe epilepsy patients: an event-related potential study of prospective memory, Twenty-third Medical Research Conference, Department of Medicine, The University of Hong Kong. 2018, 24(Suppl 1): 60. |
| Researcher : Yang D |
| List of Research Outputs |
| Zhu R.X., Yang D. and Seto W.K.W., Impact of wild-type and carboxyl-terminal truncated hepatitis B virus X on hepatocyte proliferation, HBx蛋白及其羧基末端缺失35个氨基酸的突变体对正常肝细胞增殖的影响, World Chinese Journal of Digestology. 世界华人消化杂志, 2018, 26: 760-768. |
| Researcher : Yao CK |
| List of Research Outputs |
| Chu H.S., Yao C.K. and Tan V.P.Y., Food Therapy in Sinosphere Asia, Journal of Clinical Gastroenterology. 2017, 28: EPub. |
| Tan V.P.Y., Chu H.S., Yao C.K. and Gibson P.R., Lactulose, Lactose and Fructose Ingestion Induces Specific Patterns of Gastrointestinal Symptoms in Chinese Subjects with Functional Dyspepsia and Irritable Bowel Symptoms., United Gastroenterology Week. 2017. |
| Yao C.K., Chu H.S. and Tan V.P.Y., Hydrogen Breath Testing In East And Southeast Asia, Journal of Clinical Gastroenterology. 2017. |
| Researcher : Yap YHD |
| Project Title: | A Therapeutic Drug Monitoring Program of Mycophenolic Acid in patients with Lupus Nephrities |
| Investigator(s): | Yap YHD |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 12/2013 |
| Completion Date: | 11/2017 |
| Project Title: | Relationship between Mycophenolic Acid Pharmacokinetics and Pharmacogenomics with treatment response and disease activity in lupus nephritis |
| Investigator(s): | Yap YHD, Ma KMM, Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Lymphocyte subset profile and clinical phenotype in lupus nephritis |
| Investigator(s): | Yap YHD, Chan DTM, Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | An Anti-Phospholipase A2 Receptor Antibody Monitoring Program for Patients with Idiopathic Membranous Nephropathy |
| Investigator(s): | Yap YHD, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2018 |
| Project Title: | Investigating the B cell signatures for disease flare and response to pre-emptive immunosuppressive therapy in patients with lupus nephritis |
| Investigator(s): | Yap YHD, Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chan K.Y., Yap Y.H.D., Yip T., Sham M.K., Lui S.L. and Chan D.T.M., Palliative Care Consultation in Advanced Chronic Kidney Disease with Pain, J Palliat Med. 2018, 21: 809-814. |
| Chao L.I., Yap Y.H.D., Chan G., Wen Y., LI H., Tang C., Li X.M., Li X.W. and Chan D.T.M., Clinical Characteristics and outcomes of lupus nephritis patients with kidney biopsy showing thrombotic microangiopathy, 55th ERA-EDTA Congress 2018, Copenhagen, Denmark . 2018. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Ma M.K., Yap Y.H.D., Li C.L., Mok M.M., Chan G.C., Kwan L.P., Lai K.N. and Tang S.C.W., Enteric coated Mycophenolate Sodium combined with low-dose steroid as first time therapy in minimal change nephrotic syndrome: an open label randomized controlled study, Oncotarget Advance publication . 2018, 2018. |
| Ma M.K., Law H.K., Tse K.S., Chan K.W., Chan G.C., Yap Y.H.D., Mok M.M., Kwan L.P., Tang S.C.W., Choy B.Y. and Chan D.T.M., Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis, Int J Urol. 2018, 2018: 25(5):450-455. |
| Sridhar S., Chan J.F.W., Yap Y.H.D., Teng L.L., Huang C., Yip C.Y., Hung F.N.I., Tang S.C.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Genotype 4 Hepatitis E Virus Is A Cause Of Chronic Hepatitis In Renal Transplant Recipients In Hong Kong, Journal Of Viral Hepatitis . 2018, 25: 209-213. |
| Yap Y.H.D., Thong K.M., Yung S.S.Y., Tang C., Ma B.M. and Chan D.T.M., Antiphospholipid antibodies in lupus nephritis – a single centre experience, 55th ERA-EDTA Congress 2018, Copenhagen, Denmark. 2018. |
| Yap Y.H.D., Hb instability, different types of Epos and their efficacy, Myanmar Renal Club Workshop, Yangon, Myanmar. 2018. |
| Yap Y.H.D., Infective complications after kidney transplantation, 5th Asian Nephrology Nursing Symposium, Hong Kong. 2017. |
| Yap Y.H.D., Infective complications after kidney transplantation, Macau Society of Nephrology Annual Scientific Meeting, Macau. 2018. |
| Yap Y.H.D., Infective complications in adult polycytic kidney disease, 4th APKD Summit, Seoul, Korea. 2018. |
| Yap Y.H.D., Liver and the Kidneys, Asia-Pacific Society of Nephrology/Hong Kong of Nephrology Continuous Medical Education Course, Hong Kong. 2017. |
| Yap Y.H.D., Tang S.O.C., Ma K.M.M., Mok M.Y., Chan G.C.W., Kwan P.Y.L. and Chan D.T.M., Longterm Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years, The Journal of Rheumatology. 2017, 44(9): 1375-1383. |
| Yap Y.H.D., Management of challenging cases of lupus nephritis, Hong Kong-Beijing-Chifang Medical Forum, Chifang, China. 2017. |
| Yap Y.H.D., Management of chronic hepatitis B virus infection in kidney transplant recipients, 19th Hong Kong Beijing Medical Exchange Forum, Wuhan, China. 2017. |
| Yap Y.H.D., Kwan P.Y.L., Ma K.M., Mok M.Y.M., Chan G.C.W. and Chan D.T.M., Preemptive immunosuppressive treatment for asymptomatic serological reactivation may reduce renal flares in patients with lupus nephritis: a cohort study., Nephrol Dial Transplant. 2018. |
| Yap Y.H.D., Tang C.S.O., Lee P., Tam C., Yam I., Yung S.S.Y. and Chan D.T.M., Relationship between B cell signatures and disease flare in lupus nephritis patients, American Society of Nephrology Kidney Week 2017, New Orleans USA. 2017. |
| Yap Y.H.D., Renal failure in older patients – burden, prevention and management, 13th International Symposium on Healthy Ageing, Hong Kong. 2018. |
| Yap Y.H.D., Screening and treatment of latent tuberculosis infection in donor and recipients, Asia-Pacific Congress of Nephrology. 2018. |
| Yap Y.H.D., Subject Editor, Nephrology (Carlton) Journal. 2018. |
| Researcher : Yau TCC |
| Project Title: | The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib |
| Investigator(s): | Yau TCC, Fan ST, Poon RTP, Pang RWC |
| Department: | Surgery |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2011 |
| Project Title: | A Pilot Study to Evaluate the Prophylactic Effects of Telbivudine for Prevention of Hepatitis B Reactivation in HBsAg Positive Patients Receiving Sorafenib Treatment for Advanced Hepatocellular Carcinoma |
| Investigator(s): | Yau TCC, Poon RTP |
| Department: | Surgery |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Project Title: | 4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases |
| Investigator(s): | Yau TCC |
| Department: | Surgery |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2013 |
| Project Title: | The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients |
| Investigator(s): | Yau TCC, Poon RTP |
| Department: | Surgery |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | A Phase II study of the safety and efficacy of PEG-BCT-100 combined with capecitabine/oxaliplatin in patients with advanced hepatocellular carcinoma (Part I) |
| Investigator(s): | Yau TCC |
| Department: | Medicine |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 04/2014 |
| Project Title: | Randomized Phase II Trial of Sorafenib, Capecitabine and Oxaliplatin (SECOX) versus Single Agent Sorafenib in Patients with Advanced Hepatocellular Carcinoma |
| Investigator(s): | Yau TCC, Cheung TT |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 04/2015 |
| Completion Date: | 09/2017 |
| Project Title: | A Prospective Validation of the Hong Kong Liver Cancer (HKLC) Prognostic Staging System: A Multi-Centre Study in Hong Kong |
| Investigator(s): | Yau TCC, Cheung TT |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | A Combination of Sorafenib, Oxaliplatin and Capecitabine as Neoadjuvant Therapy for Patients with Locally Advanced Hepatocelullar Carcinoma: A Phase II Study |
| Investigator(s): | Yau TCC, Cheung TT |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2016 |
| Project Title: | A Phase 1b Study of Polo-like Kinase 4 inhibitor CFI-400945 in Advanced Hepatocellular Carcinoma |
| Investigator(s): | Yau TCC, Wong CCL, Chiu WYJ |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| Cheung T.T., Kwok P.C., Chan S., Cheung C.C., Lee A.S., Lee V.H.F., Cheng H.C., Chia N.H., Chong C.C.N., Lai T.W., Law A.L.Y., Luk M.Y., Tong C.C. and Yau T.C.C., Hong Kong Consensus Statements for the Management of Unresectable Hepatocellular Carcinoma, Liver Cancer. 2018, 7: 40-54. |
| Chiu W.Y.J., Leung R., Hze H., Teo P., Choi P., Yau T.C.C., Cheng P., Cheung F.Y. and Cheung P., Real world data on use of palbociclib in hormone-receptor positive HER2 negative metastatic breast cancer among Asian patients, European Society for Medical Oncology Asia (ESMO ASIA) 2017 Congress (17-19 November 2017). 2017. |
| Lam K.O., Lee K.C., Chiu W.Y.J., Lee V.H.F., Leung R.C.Y., Choy T.S. and Yau T.C.C., The Real World Use of Regorafenib for Metastatic Colorectal Cancer: Multicenter Analysis of Treatment Pattern and Outcomes in Hong Kong, Postgraduate Medical Journal. 2017, 395-400. |
| Lim H.Y., Merle P., Weiss K.H., Yau T.C.C., Ross P., Mazzaferro V., Blanc J.F., Ma Y.T., Yen C.J., Kocsis J., Choo S.P., Sukeepaisarnjaroen W., Gérolami R., Dufour J.F., Gane E.J., Ryoo B.Y., Peck-Radosavljevic M., Dao T., Yeo W., Lamlertthon W., Thongsawat S., Teufel M., Roth K., Reis D., Childs B.H., Krissel H. and Llovet J.M., Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-Mutated Hepatocellular Carcinoma, Clinical Cancer Research. 2018, 24: 4650-4661. |
| Ng L., Chow K.M., Man H.W., Yau T.C.C., Wan T.M.H., Iyer D.N., Kwan V.H.T., Poon R.T.P., Pang R.W.C. and Law W.L., Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK 3β/β-catenin pathway, BMC Cancer. 2018, 18(1): 621. |
| Yau T.C.C., Advances in the Management of Advanced Pancreatic Cancer, Zhejiang University International Hospital, Hangzhou, China. 2017. |
| Yau T.C.C., Approaches to Clinical Cases, The 1st Asian NET Expert Meeting, Incheon, South Korea. 2018. |
| Yau T.C.C., Cancer Immunotherapy: Recent Advances and Impact on Survival, 1st HKU International Musculoskeletal Tumour Course, Hong Kong. 2017. |
| Yau T.C.C., Checkpoint Inhibitors: Taking Off the Brakes in Immune System, State key Laboratory for Liver Research Symposium 2017, Hong Kong. 2017. |
| Yau T.C.C., Debate: The Immune System is the Final Answer for against HCC, The 8th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2017), Singapore. 2017. |
| Yau T.C.C., Evolving Landscape in unresectable HCC, Bayer Asia Pacific Hepatocellular Carcinoma Advisory Board, ChiangMai, Thailand. 2018. |
| Yau T.C.C., HK Real life Use of Sorafenib in HCC and How to Apply NexST sequence in Clinical Practice, Bayer HCC Stivarga HCC launch symposium—Optimal use of Systemic Therapy, Hong Kong. 2018. |
| Yau T.C.C., Hong Kong Liver Cancer Staging, 53rd Annual Meeting of Liver Cancer Study Group of Japan, Tokyo, Japan. 2017. |
| Yau T.C.C., Immune Checkpoint Inhibitors in HCC, 2017 Seoul Liver Symposium, Seoul, South Korea. 2017. |
| Yau T.C.C., Immunotherapy for Advanced Hepatocellular Carcinoma: At the Dawn of a New Era, 2nd Singapore Liver Cancer Consortium (SLCC) Symposium Programme, Singapore. 2018. |
| Yau T.C.C., Immunotherapy for Pancreatic Cancer: Are We There Yet?, Asia Pacific Digestive Week 2017, Hong Kong. 2017. |
| Yau T.C.C., Immunotherapy in HCC – a paradigm change, Fifth Asia Pacific Gastroenterology Cancer Summit 2018, Singapore. 2018. |
| Yau T.C.C., New Era of Systemic Therapy in unresectable HCC: Insights from RESORCE Study, Bayer Asia Pacific Hepatocellular Carcinoma Round Table Discussion, Macau. 2018. |
| Yau T.C.C., Phase I trial of Recombinant Human Arginase 1 (PEG-BCT-100) combined with Capecitabine and Oxaliplatin (PACOX) in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma, Symposium of Pegylated Human Recombinant Arginase in the Treatment of Cancers and other human Disease, Hong Kong. 2017. |
| Yau T.C.C., Recent Advances in Targeted Therapy in Soft Tissue Sarcoma, Pre-course Symposium: Precision Medicine in Sarcoma, 1st HKU International Musculoskeletal Tumour Course, Hong Kong. 2017. |
| Yau T.C.C., The Role of Anti-EGFR and Tumor Location in 1st line Treatment of Metastatic Colorectal Cancer, The Oncology Symposium on mCRC Management, Ho Chi Minh City, Vietnam. 2017. |
| Yau T.C.C., Updates in the Management of Refractory Colorectal Cancer, Bayer Macau Colorectal Cancer Round Table Discussion, Macau. 2018. |
| Researcher : Ye D |
| Project Title: | Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota |
| Investigator(s): | Ye D |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Researcher : Yeung CK |
| Project Title: | HLA-B* 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong |
| Investigator(s): | Yeung CK, Tang SCW, Cheung BMY |
| Department: | Medicine |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2012 |
| Researcher : Yeung MY |
| List of Research Outputs |
| Lee C.H.P., Gu Y., Yeung M.Y., Fong H.Y., Woo Y.C., Chow W.S., Tan K.C.B. and Lam K.S.L., Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study, Diabetes Therapy. 2018, 9: 285-295. |
| Researcher : Yeung SC |
| List of Research Outputs |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Comparative analysis of high-fat diet and intermittent hypoxia impacts on C57BL/6N and C57BL/6J mouse strains, 23rd Medical Research Conference, Department of Medicine, HKU, Jan 2018. Hong Kong Medical Journal. 2018, 24 (Suppl.1): 25. |
| Ge M., Yeung S.C., Mak J.C.W. and Ip M.S.M., Differential effects of high fat diet and intermittent hypoxia on C57BL/6N and C57BL/6J mouse strains., American Thoracic Society International Conference, Sam Diego, USA, May 2018, American Journal of Respiratory and Critical Care Medicine. 2018, 197: A6407. |
| Liang Y., Liu W.K.K., Yeung S.C., LI X., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats, Frontiers in Pharmacology. 2017, 8: 618. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Researcher : Yick LW |
| Project Title: | Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation |
| Investigator(s): | Yick LW, Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| List of Research Outputs |
| Chan K.H. and Yick L.W., Aquaporin-4 IgG autoantibodies from neuromyelitis optica spectrum disorder patients cause complement-independent spinal cord pathologies and motor deficits in mice, European Academy of Neurology Annual Meeting 2018. |
| Chan K.H. and Yick L.W., Passive transfer of human aquaporin-4 IgG autoantibodies causes complement-independent spinal cord immunopathologies in mice, American Academy of Neurology 70th Annual Meeting. 2018. |
| Yick L.W., Ma K.F.O., Ng C.L., Kwan S.C. and Chan K.H., Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice, Frontiers in Immunology . 2018, 9: 1438. |
| Researcher : Yim RLH |
| List of Research Outputs |
| Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018. |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017. |
| Researcher : Yip TPS |
| List of Research Outputs |
| Chan G.C.W., Lee C.H.P., Kwan P.Y.L., Yip T.P.S. and Tang S.C.W., Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism, Nephrology. 2017, 22: 572-572. |
| Hung F.N.I., Yap Y.H.D., Tang S.C.W., Yip T.P.S., Chan K.H. and Yuen K.Y., Topical imiquimod before intradermal hepatitis B vaccination in patients on dialysis , American Association for the Study of Liver Diseases AASLD 2017. Late-breaker Oral Presentation. 2017. |
| Researcher : Yiu KH |
| Project Title: | Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis |
| Investigator(s): | Yiu KH, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Reversibility of liver stiffness after tricuspid annulopasty: A case-control study |
| Investigator(s): | Yiu KH, Tse HF, Seto WKW |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Development Of A Novel Cardiac Imaging Technique To Detect Silent Brain Infarction In The Elderly To Prevent Subsequent Vascular Dementia |
| Investigator(s): | Yiu KH, Lee W, Mak HKF |
| Department: | Medicine |
| Source(s) of Funding: | Midstream Research Programme for Universities (MRP) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chan Y.H., Yiu K.H., Hai S.H.J.J., Chan P.H.M., Lam T.H., Cowling B.J., Sham P.C., Lau C.P., Lam K.S.L., Siu D.C.W. and Tse H.F., Genetically deprived vitamin D exposure predisposes to atrial fibrillation, EP Europace. 2017, 19: iv25-iv31. |
| Chan Y.H., Hai S.H.J.J., Lau G.K.K., Li L.S.W., Lau C.P., Siu D.C.W., Yiu K.H. and Tse H.F., PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights, BMC Cardiovascular Disorders. 2017, 17. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017. |
| Jim M.H., Wu E.B., Chan C.Y., Wong K.L., Fung R.C. and Yiu K.H., Angiographic study of the clinical liaison of drug-eluting stent and paclitaxel-eluting balloon in unifocal side branch ostium stenosis (ASCLEPIUS)., Heart Vessels. 2017, 2017 Mar. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Shih K.C., Kua W.N., Chan C., Wong Y.H.I. and Yiu K.H., Diabetic Retinopathy Status as a Marker for More Severe Reduction in Circulating Endothelial Progenitor Cells and Systemic Atherosclerosis in Diabetics, Annual Scientific Meeting of the Japanese Ophthalmological Society 2018. |
| WANG Y., ZHEN Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., A case-control study on periodontitis and left ventricular function in patients with diabetes, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD156. |
| WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Pelekos G., Tonetti M. and Jin L., Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients, Journal of Clinical Periodontology. 2017, 44: 1253-1263. |
| Yiu K.H., 2017. Interviewee: Mental Health Promotion for Medical Students ”Dr Writes醫依筆寫’On the stress and struggles in clinical practice”, Medical Summer Broadening Programme Faculty of Medicine. 2017. |
| Yiu K.H., Chen Y., Liu J.H., Lin Q., Liu M., Wu M., Wang R., Zhen Z., Zou Y., Lam Y.M., Ng M.Y., Lau C.P. and Tse H.F., Burden and contributing factors associated with tricuspid regurgitation: a hospital-based study, Hospital Practice. 2017. |
| Yiu K.H., Clinical Perspectives of Coronary Intravascular Ultrasound and Optical Coherence Tomography, 7th IDKD Intensive Course in Asia. 2017. |
| Yiu K.H. and Tse H.F., Editorial commentary: Heart failure in systemic lupus erythematosus: A problem to address, Trends in Cardiovascular Medicine. 2018, 28: 198-199. |
| Yiu K.H., Invited Speaker, 2017 International Cardiovascular Frontiers-Futian Forum” 论坛主题：国际名医大咖联合查房,” PCI临床应用指南”, 2017. |
| Yiu K.H., Invited Speaker, 2018 APHRS Taipei, Taiwan, “ ICD in Non Ischemic Cardiomyopathy”, 2018. |
| Yiu K.H., Invited Speaker, APAC Physiology Thought Leaders’ Forum Seoul, South Korea, 2018. |
| Yiu K.H., Invited Speaker, Beijing Cardiac International Symposium2017 Beijing, China ”Belt and Road”, 2017. |
| Yiu K.H., Invited Speaker, European Society of Cardiology 2017, “Cardiorenal syndrome in patients with valvular heart disease”, 2017. |
| Yiu K.H., Invited Speaker, Hong Kong Dental Congress 2017,” Oral Health and aging population: A medical”, 2017. |
| Yiu K.H., Invited Speaker, The 28th GW-ICC Scientific, Beijing, China “Diagnosis Value of High Sensitive Troponin in Patients with Chest Pain”, 2017. |
| Yiu K.H., Invited Speaker, The Richard Yu Lectureship, Hong Kong College of Physicians ,“Cardiovascular manifestation in systemic inflammatory disorders”, 2017. |
| Yiu K.H., Invited Speaker,广州会议-心血管介入论坛暨心衰的治疗历史与现状论坛, “右心衰的诊治进展”, 2018. |
| Yiu K.H., Invited Speaker,港大深圳醫院住培招生宣講, 2018. |
| Yiu K.H., Oral health and aging population: A medical, Hong Kong Dental Congress. 2017. |
| Yiu K.H., Panelist, “2017協和住院醫師培訓國際論壇”co-organised by China Medical Board In Beijing, 2017. |
| Yiu K.H., Panelist,” HKSTENT –Bifurcation PCI Workshop & Cases Competition, Hong Kong, 2018. |
| ZHAO D., Yiu K.H., Zhen Z., Pelekos G., Tonetti M. and Jin L., Oral/periodontal conditions are closely associated with general health status and comorbidity profiles, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD128. |
| Researcher : Yiu WH |
| Project Title: | ASN Kidney Week 2013 Annual Meeting ; Tissue Kallikrein Mediates Pro-inflammatory Pathways in Proximal Tubular Epithelial Cells |
| Investigator(s): | Yiu WH |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2013 |
| List of Research Outputs |
| Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017. |
| Hill C., Price G.W., Wall M.J., Kaufmann T.J., Tang S.C.W., Yiu W.H. and Squires P.E., Transforming Growth Factor Beta 1 Drives a Switch in Connexin Mediated Cell-to-Cell Communication in Tubular Cells of the Diabetic Kidney, Cell Physiol Biochem. 2018, 2018: 45(6):2369-2388. |
| Wong W.L.D., Yiu W.H., Chan K.W., LI Y., LI B., Lok S.W.Y., Taketo M.M., Igarashi P., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Activated renal tubular Wnt/!b-catenin signaling triggers renal inflammation during overload proteinuria, Kidney Int.. 2018, 2018: 93(6):1367-1383. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| Yiu W.H., Li R.X., Wong W.L.D., Wu H.J., Chan K.W., Chan Y.Y., Leung J.C.K., Lai K.N., Sacks S.H., Zhou W. and Tang S.C.W., Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy, Nephrol Dial Transplant. 2017, 2016. |
| Researcher : Yuen JCH |
| List of Research Outputs |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Researcher : Yuen MAM |
| List of Research Outputs |
| Cheung Y.Y., Lee C.H.A., Tang S.M., Xu A., Au K.W., Fong H.Y., Kwok H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy ad Estimated glomerular Filtration Rate in chinese Patients with Type 2 Diabetes., 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon.. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., KWOK H.M., Chow W.S., Yuen M.A.M., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Exome-Chip Association Analyses for Diabetic Nephropathy and Estimated Glomerular Filtration Rate in Chinese Patients with Type 2 Diabetes, 53rd Annual Meeting of the European Association for the Study of Diabetes, 11- 15 Sep 2017, Lisbon. 2017. |
| Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Fong H.Y., NG K.K., Chow W.S., Woo Y.C., Yuen M.A.M., Tan K.C.B., Tse H.F., Sham P.C. and Lam K.S.L., Exome-chip association analysis on a multifunctional anti-tumor factor, pigment epithelium-derived factor (PEDF), in patients with type 2 diabetes, 13th International Symposium on Healthy Aging, Hong Kong. 2018. |
| Cheung Y.Y., Lee C.H.P., KWOK H.M., Woo Y.C., Yuen M.A.M., Chow W.S., Fong H.Y., Wong L.C., Xu A., Sham P.C. and Lam K.S.L., Impact of genetic variants identified in genome-wide association studies of diabetic retinopathy in Chinese patients with type 2 diabetes. , American Society of Human Genetics Annual Meeting 2017, Orlando, United States.. 2017. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Researcher : Yuen MF |
| Project Title: | An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Glaxo Wellcome Hong Kong Ltd. - General Award |
| Start Date: | 07/2005 |
| Project Title: | Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 01/2006 |
| Project Title: | A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | PowderMed Ltd - General Award |
| Start Date: | 11/2006 |
| Project Title: | Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 09/2007 |
| Project Title: | Outstanding Researcher Award 2009-10 |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2010 |
| List of Research Outputs |
| Researcher : Yuen RMF |
| Project Title: | An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Glaxo Wellcome Hong Kong Ltd. - General Award |
| Start Date: | 07/2005 |
| Project Title: | Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 01/2006 |
| Project Title: | A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | PowderMed Ltd - General Award |
| Start Date: | 11/2006 |
| Project Title: | Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb (HK) - General Award |
| Start Date: | 09/2007 |
| Project Title: | Outstanding Researcher Award 2009-10 |
| Investigator(s): | Yuen RMF |
| Department: | Medicine |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2010 |
| List of Research Outputs |
| APASL ACLF W.O.R.K.I.N.G. .P., Sahu M.K., Nath P., Choudhury A.K., Mahtab M.A.I., Rehman S., Devarbhavi H., Duan Z., Chen Y., Kim D.J., Jia J.D., Eapen C.E., Goel A., Ning Q., Chawla Y.K., Dhiman R.K., Duseja A., Taneja S., Hamid S.S., Butt A.S., Jafri W., Tam S.S., Ghazinian H., Amarapurkar D.N., Treeprasertsu S., Lee G.H., Lim S.G., Hu J.H., Lesmana L.A., Lesmana C.R., Shukla A., Shah S., Kalal C., Abbas Z., Sollano J.D., Carpio G., Karim M.F., Lau G.K., Rao P.N., Payawal D.A., Dokmeci A.K., Yuen R.M.F., Prasad V.G.M., Yokosuka O., Prasad A., Jain P., Paulson I. and Sarin S.K., The prognostic determinant in acute on chronic liver failure: a multicentre prospective cohort study, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver, 14-18 March 2018. Hepatology International (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S198. |
| APASL ACLF W.O.R.K.I.N.G. .P.A., Al Mahtab M., Rehman S., Devarbhavi2 H., Duan Z.P., Chen Y., Kim D.J., Jia J.D., Eapen C.E., Goel A., Ning Q., Chawla Y.K., Dhiman R.K., Duseja A., Taneja S., Hamid S.S., Butt A.S., Jafri W., Tan S.S., Ghazinian H., Amarapurkar D.N., Treeprasertsuk S., Lee G.H., Lim S.G., Hu J.H., Lesmana L.A., Lesmana C.R., Shukla A., Shah S., Kalal C., Abbas Z., Sollano J.D., Carpio G., Karim M.F., Lau G.K., Rao P.N., Payawal D.A., Dokmeci A.K., Yuen R.M.F., Prasad V.G.M., Yokosuka O., Prasad A., Jain P., Paulson I., Sarin S.K., Sahu M.K., Singh A. and Choudhury A.R., Profile of ACLF cases in Asia: A multicentre study, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S197. |
| Ahmad J., Choudhury A., Kumar M., Hu J.H., ...... .........., Tan S.S., Hamid S.S., Subhan A., Jafri W., Lesmana L.A., Lesmana R., Ghazinyan H.L., Jia J.D., Lee G.H., Lim S.G., Taneja S., Chawla Y., Lau G., Sahoo M., Shukla A., Deverbhavi H., Yuen R.M.F., Abbas Z., Amarappurkar D., Karim F., Treeprasertsuk S., Dokmed A.K., Goel A., Eapen C., Payawal D., Shah S., Kalal C., Kulkarni A., Chaudhury S., Paulson I., Jain P., Kumar G. and Sarin S.K., Tenofovir is more potent over entecavir in reducing the viral load in patients of hepatitis B reactivation presenting as Acute on Chronic Liver Failure (ACLF)-Results of multination study from APASL-ACLF Research Consortium (AARC), Journal of Hepatology. 2018, 68: S245. |
| Buter E.K., Wong D.K.H., Jackson K., Schluep T., Gersch J., Kuhns M., Cloherty G.A., Locarnini S. and Yuen R.M.F., Utility of a new HBV RNA assay in HBeAg positive and negative CHB and following HBsAg seroclearance in patients treated with ARC‐520, an RNAi drug targeting cccDNA derived HBV mRNA, 16th International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD) held from June 14th to 17th, 2018, in Toronto, Canada. Journal of Viral Hepatitis. 2018, 25(2): 190-191. |
| Chan H.L.Y., Chen C.J., Omede O., Al Qamish J., Al Naamani K., Bane A., Tan S.S., Simonova M., Cardenas I., Derbala M., Akin O., Phillips R.O., .... ........, Yuen R.M.F. and Nde H., The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4, Journal of Viral Hepatitis. 2017, 24 (Suppl 2): 25-43. |
| Chen D.S., Hamoudi W., Mustapha B., Layden J., Nersesov A., Reic T., Garcia V., Rios C., Mateva L., ..... ........, Yuen R.M.F. and Schmelzer J.D., Strategies to manage hepatitis C virus infection disease burden-Volume 4, Journal of Viral Hepatitis. 2017, 24 (Suppl 2): 44-63. |
| Chen T., Ma K., Choudhury A.K., Sharma M.K., ..... .........., Yuen R.M.F. and Ning Q., Validation of TPPM Score in predicting short-term survival in HBV-ACLF patients: a multi-national study from APASL ACLF Research Consortium (AARC), Hepatology. 2017, 66: 681A. |
| Cheung K.S., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Journal of Hepatology. 2018, 68: S516-S517. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015, Clin Transl Gastroenterol. 2017, 8(8): e116. |
| Cheung K.S., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis, World Journal of Gastroenterology. 2017, 23: 7863-7874. |
| Cheung K.S.M., Mak L.Y., Seto W.K.W., Wong D.K.H., LIU F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Association of metabolic adipokines with persistence of fibrosis in chronic hepatitis B during long-term nucleoside analogue therapy, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S516. |
| Cheung K.S.M., Seto W.K.W., Fung J.Y.Y., Mak L.Y., Lai C.L. and Yuen R.M.F., Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016, World Journal of Gastroenterology. 2017, 23: 7716-7726. |
| Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J., Li W., Zhao X.M., Wang Z. and Mu S., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants, Clinical Therapeutics. 2018, 40: 719-732.e1. |
| Duan D.J., Kim T.Y., Choudhury A.K., Jia J.D., Sarin S.K., Jain I., Paulson P., Al Mahtab M., Rahman S., Devarbhavi H., Duan Z.P., Chen Y., Eapen C.E., Goel A., Ning Q., Lau G., Rao P.N., Alcantarapayawal D., Dokmeci A.K., Yuen R.M.F., Prasad V.G.M. and Yokosuka O., Usefulness of lactate-free Asian Pacific Association for the Study of Liver acute-on-chronic liver failure (ACLF) Research Consortium (AARC) ‘‘ACLF score for predicting short-term mortality in patients with alcoholic liver disease, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S184. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance, Hepatology. 2018, 68(2): 462-472. |
| Fung J.Y.Y., Cheung K.S.M., Wong D.K.H., Mak L.Y., To W.P., Seto W.K.W., Lai C.L. and Yuen R.M.F., Long-term outcomes and significance of HBeAg Seroclearance in Chronic Hepatitis B: Novel Predictive Scores for HCC and HBsAg seroclearance, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S486-S487. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Sin S.L., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleos(t)ide analogs alone after liver transplantation in chronic hepatitis B with preexisting rt204 mutation, Transplantation. 2017, 101(10):: 2391-2398. |
| Fung J.Y.Y., Wong C.L.T., Chok K.S.H., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Mak K.W., Ng K., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Prevalence of graft steatosis after liver transplantation using controlled attenuation parameter measurements: a large cohort study, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 914A. |
| Gane E., Liu A., Yuen R.M.F., Schwabe C., Bo Q., Das S., Goa L., Zhou X., Wang Y., Coakley E. and Jin Y., RO7049389, a core protein allosteric modulator, demonstrates robust anti-HBVactivity in chronic hepatitis B patients and is safe and well tolerated, Oral Presentation at the International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S101. |
| Gane E., Liu A., Yuen R.M.F., Schwabe C., Bo Q., Das S.B., Goa L., Zhoa X., Wang Y., Coakley E. and Jin Y., RO7049389, a core protein allosteric modulator, is safe and well tolerated in healthy volunteers and demonstrates potent anti-HBV activity in a phase 1 trial, 16th International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD) held from June 14th to 17th, 2018, in Toronto, Canada; Journal of Viral Hepatitis. 2018, 25(2): 46-47. |
| Hui R.W.H., Seto W.K.W., Cheung K.S., Mak L.Y., Liu S.H.K., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study, J Viral Hepat. 2017. |
| Hui Y.T., Wong G., Liu S.H.K., ..... ......, Yuen R.M.F. and Wong V.W.S., Real world efficacy and tolerability of direct-acting antiviral for treatment of chronic hepatitis C infection: interim results of a territory-wide study in Hong Kong, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. 2018, 12 (Suppl 2): 1S519. |
| Hui Y.T., Wong G., Liu S.D., Liu S.H.K., Ma Y.K., But Y.K.D., .... ........, Yuen R.M.F. and Wong V.W.S., Territory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong, Journal of Gastroenterology and Hepatology. 2017, 32: 158-159. |
| Kim D.J., Kim T.K., Choudhury A.K., Jia J.D., Jain P., Paulson I., Al Mahtab A.I., Rahman S., Devarbhavi H., Duan Z.P., Chen Y., Eapen C.E., Goel A., Ning Q., Lau G.K., Rao P.N., Alcantarapayawal D., Dokmeci A.K., Yuen R.M.F., Prasad V.G.N., Yokosuka O. and Prasad A.S., The prognostic stratification using acute-on-chronic liver failure scoring system for predicting short-term mortality in patients with alcoholic hepatitis, 27th Annual Conference of APASL, March 14–18, 2018, New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S195. |
| Lai C.L., Wong D.K.H., Yuen J.C.H., Wu C.H., Cheng C.T.K., Ngai W.S., Kopaniszen M., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable cccDNA, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66(Suppl 1): 512A. |
| Lam Y.F., Seto W.K.W., Wong D.K.H., Cheung K.S., Fung J.Y.Y., Mak L.Y., Yuen J.C.H., Chong C.K., Lai C.L. and Yuen R.M.F., Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels, Clinical and Translational Gastroenterology. 2017, 8: e125. |
| Locarnini S., Wong D.K.H., Jackson K., Walsh R., Edwards R., Hammond R., Macfarlane C., Iyer R.P., Afdhal N.H. and Yuen R.M.F., Novel anti-viral activity of SB 9200, a RIGI agonist; results from Cohort 1 of the ACHIEVE trial, Hepatology. 2017, 66(6): 1269A-1270A. |
| Maaroufi A., Vince A., Himatt S.M., Mohamed R R., Fung J.Y.Y., Opare-Sem O., Workneh A., Njouom R., Al Ghazzawi I., Abdulla M., Kaliaskarova K.S., ..... ......, Yuen R.M.F. and Razavi-Shearer K., Historical epidemiology of hepatitis C virus in select countries-volume 4, Journal of Viral Hepatitis. 2017, 24 (Suppl 2): 8-24. |
| Macfarlane C., Locarnini S., Jackson K., Walsh R., Edwards R., Hammond R., Coffin C., Elkhashab M., Greenbloom S., Ramji A., Chan H.L.Y., Afdhal W., Kim N., Afdhal N., Yuen R.M.F., Wong D.K.H. and Lyer R., Inarigivir: a novel RIG-I agonist for chronic hepatitis B, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. Tokyo, Springer Science & Business Media, 2018, 12 (Suppl 2): S264. |
| Maiwall R., Sarin S.K., Kumar S., Jain P., Kumar G., Bhadoria A.S., Moreau R., Kedarisetty C.K., Abbas Z., Amarapurkar D., Bhardwaj A., Bihari C., Butt A.S., Chan A.C.Y., Chawla Y.K., Chowdhury A., Dhiman R., Dokmeci A.K., Ghazinyan H., Hamid S.S., Kim D.J., Komolmil P., Lau G.K., Lee G.H., Lesmana L.A., Jamwal K., Mamun-Al M., Mathur R.P., Nayak S.L., Ning Q., Pamecha V., Alcantara-Payawal D., Rastogi A., Rahman S., Rela M., Saraswat V.A., Shah S., Shiha G., Sharma B.C., Sharma M.K., Sharma K., Tan S.S., Chandel S.S., Vashishtha C., Wani Z.A., Yuen R.M.F., Yokosuka O., Duseja A., Jafri W., Devarbhavi H., Eapen C.E., Goel A., Sood A., Ji J., Duan Z. and Chen Y., Development of predisposition, injury, response, organ failure model for predicting acute kidney injury in acute on chronic liver failure, Liver International. 2017, 37: 1497-1507. |
| Maiwall R., Choudhury A.K., Sharma B.C., ...... .........., Yuen R.M.F., Sarin S.K. and Party A.A.W., Dynamic AARC-AKI score determines Extrarenal Organ Failures and Bacterial Infection in patients with Acute on Chronic Liver Failure, Hepatology. 2017, 66: 288A. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., An update on the toxicological considerations for protease inhibitors used for hepatitis C infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14(5): 483-491. |
| Mak L.Y., Cruz-Ramón V., Chinchilla-López P., Torres H.A., LoConte N.K., Rice J.P., Foxhall L.E., Sturgis E.M., Merrill J.K., Bailey H.H., Méndez-Sánchez N., Yuen R.M.F. and Hwang J.P., Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma, American Society of Clinical Oncology Educational Book. 2018, 262-279. |
| Mak L.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Hepatitis B core protein as a therapeutic target, Expert Opinion on Therapeutic Targets. 2017, 21: 1153-1159. |
| Mak L.Y. and Yuen R.M.F., Letter: serum HBcrAg is a useful marker for disease monitoring, predicting treatment response and disease outcome of chronic hepatitis B virus infection-authors' reply, Alimentary Pharmacology & Therapeutics. 2018, 47: 1720-1721. |
| Mak L.Y., Seto W.K.W., Lai C.L. and Yuen R.M.F., Pharmacokinetic evaluation of besifovir for the treatment of HBV infection, Expert Opinion on Drug Metabolism & Toxicology. 2018, 14: 101-106. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, Alimentary Pharmacology & Therapeutics. 2018, 47: 43-54. |
| Mak L.Y., Wong D.K.H., Cheung K.S., Seto W.K.W., Lai C.L. and Yuen R.M.F., Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection, Clinical and Translational Gastroenterology. 2018, 9: 163. |
| Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer in assessing liver fibrosis in chronic hepatitis B infection, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S496. |
| Nguyen M.H., Yang H.I., Yeh M.L., .... ........, Yuen R.M.F. and Yu M.L., REAL-B (Real-world Effectiveness from the Asia Pacific Rim Liver Consortium for HBV) - A Risk Score for the Prediction of Hepatocellular Carcinoma (HCC) in Chronic Hepatitis (CHB) Patients Treated with Oral Anti-HBV Therapy, Hepatology. 2017, 66: 98A-99A. |
| Pande A., Choudhury A., Kumar M., Rahman S., Deverbhavi H., Duan Z., Kim D.J., Eapen C., Ning G., Chawla Y., Jafri W., Tan S.S., Ghazinyan H.L., Amarapurkar D., Treeprasertsuk S., Lee G.H., Hu J.H., Lesmana L.A., Shukla A., Shah S., Katal C., Sahoo M., Abbas Z., Joyes S., Karim F., Lau G., Padaki N.R., Payawai D., Kadir Dokmeci A., Sarawat V., Yuen R.M.F., Gm V., Yokosuka O., Shrestha A., Paulson I., Jian P., Kumar G. and Sarin S.K., Impact of organ failure in patients with acute on chronic liver failure (ACLF) and the newly defined AARC liver failure score in predicting 90 days survival-results from APASAL-ACLF research consortium (AARC), Journal of Hepatology. 2018, 68: S244-S245. |
| Polaris Observatory Collaborators ,..........., Chen D.S., ..... ........, Yuen R.M.F., Yusu M.A.M. and Zeuzem S., Razavi H., Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study, The Lancet Gastroenterology & Hepatology. 2018, 3: 383-403. |
| Prasad D., Choudhury A.K., AI Mahtab M., Dokmeci A.K., Karim M.D... .F., Alcantarapayawal D., Yuen R.M.F., Mohan V.G., Lau G.K., Yokosuka O., Prasad A.S., Jain P., Paulson I., Sarin S.K., Rahman S., Devarbhavi H., Duan Z.P., Chen Y., Ning Q., Eapen C.E., Goel A., Chawla Y.K., Taneja S., Dhiman R.K., Duseja A., Hamid S.S., Butt A.S., Jafri W., Tan S., Kim D.J., Jia J.D., Amarapurkar D.N., Ghazinian H., Hu J.H., Lee G.H., Lim S.G., Lesmana L.A., Lesmana C.R., Shukla A., Treeprasertsuk S., Shah S., Kalal C., Abbas Z., Sollano J.D., Carpio G., Sahu M.K. and Rao P.N., Higher baseline MAP protects against organ failure in patients of acute on chronic liver failure (ACLF). Hepatology International, 27th Annual Conference of APASL, March 14–18, 2018, New Delhi, India, 14-18 March 2018. Hepatology International. Springer Science & Business Media, 2018, 12 (Suppl 2): S621. |
| Sawai H., Nishida N., Khor S.S., Masao H., Sugiyama M., Baba N., Yamada K., Sawada N., Tsugane S., Koike K., Kondo Y., Yatsuhashi H., Nagoaka S., Taketomi A., Fukai M., Kurosaki M., Izumi N., Kang J.H., Murata K., Hino K., Nishina S., Matsumoto A., Tanaka E., Sakamoto N., Ogawa K., Yamamoto K., Tamori A., Yokosuka O., Kanda T., Sakaida I., Itoh Y., Eguchi Y., Oeda S., Mochida S., Yuen R.M.F., Seto W.K.W., Poovorawan Y., Posuwan N., Mizokami M. and Tokunaga K., Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma, Scientific Reports. 2018, 8. |
| Seto W.K.W., Lai C.L. and Yuen R.M.F., Adefovir dipivoxil, In: Grayson ML, Crowe S, MaCarthy M, Mills J. Mouton J, Paterson DL, Cosgrove SE, Hope W, Kucers' The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs. CRC Press, 2017, 255: 3-15. |
| Seto W.K.W., Hui R., Mak L.Y., Fung J.Y.Y., Cheung K.S., Liu S.H.K., Wong D.K.H., Lai C.L. and Yuen R.M.F., Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B, Clinical Gastroenterology and Hepatology. 2018, 16: 575-583.e2. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody therapy: a prospective observational study, Hepatology. 2017, 66: 1009A-1009A. |
| Seto W.K.W., Mak L.Y., Liu S.H.K., Cheung K.S.M., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Feasibility of strategic monitoring in patients with prior HBV exposure undergoing anti-CD20 monoclonal antibody, Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 1009A. |
| Seto W.K.W., Mak S.K., Chiu W.H.K., Vardhanabhuti V., Wong H.F., Leong H.T., Lee P., Ho Y.C., Lee C.K., Cheung K.S., Yuen R.M.F. and Leung W.K., Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users, Journal of Hepatology. 2018. |
| To W.P., Wong D.K.H., Mak L.Y., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S478. |
| Walsh R., Hammond R., Jackson K., Edwards E., Macfarlane C., Iyer R., Yuen R.M.F., Chan H., Afdhal N. and Locarnini S., Effects of SB9200 (Inarigivir) therapy on immune responses in patients with chronic hepatitis B, Oral Presentation at the International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S89. |
| Walsh R., Hammond R., Jackson K., Edwards C., Macfarlane R., Iyer R., Yuen R.M.F., Chan H., Afdhal N. and Locarnini S., Effects of SB9200 (Inarigivir) therapy on immune responses in patients with chronic hepatitis B, The International Liver Congress 2018 (EASL 2018), 14-18 April 2018, Paris, France. Journal of Hepatology. 2018, 68: S89. |
| Wong D.K.H., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Occult hepatitis B infection in hepatocellular carcinoma patients with negative HBsAg, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S474. |
| Wong G.L.H., Seto W.K.W., Wong V.W.S., Yuen R.M.F. and Chan H.L., Review article: long-term safety of oral anti-viral treatment for chronic hepatitis B, Alimentary Pharmacology & Therapeutics. 2018, 47: 730-737. |
| Wooddell C.I., Yuen R.M.F., Chan H.L.Y., Gish R.G., Locarnini S.A., Chavez D., Ferrari C., Given B.D., Hamilton J., Kanner S.B., Lai C.L., Lai J.Y.N., Schluep T., Xu Z., Lanford R.E. and Lewis D.L., RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg, Science Translational Medicine. 2017, 9: eaan0241. |
| Yeo Y.H., Ho H.J., Yang H.I., Tseng T.C., Kwak M.S., Park Y.M., Fung J.Y.Y., Buti M., Rodriguez M., Treeprasertsuk S., Preda C.M., Ungtrakul T., Charatcharoenwitthaya P., Li X.Y., Le M.H., Wei B., Zou B.Y., Le A.K., Jeong D., Chien N., Kam L., Hosakh T., Rivetro M., Proca D., Suzuki F., Kobayashi M., SSriprayoon T., Chong Y., Tanwandee T., Yuen R.M.F., Lee H.S., Kao J.H., Lok A., Wu C.Y. and Nguyen M.H., Sa1483 - Real-World Rates of Hepatitis B Surface Antigen (HBSAG) Seroclearance in Patients with Chronic Hepatitis B (CHB): A Systematic Review, Conventional Aggregated Data Meta-Analysis (ADMA) and Individual Patient Data Meta-Analysis (IPDMA), Gastroenterology. 2018, 154: S-1128. |
| Younossi Z., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang Y.L., Kao J.H., Kinh N., Lai C.L., Yuen R.M.F., Chan H.L.Y. and Lai W., Sofosbuvir (SOF) and ledipasvir (LDV) combination is associated with high sustained virologic response (SVR) and improvement of health-related quality of life (HRQL) in East Asian patients with hepatitis C virus (HCV) infection, 27th Annual Conference of the Asian Pacific Association for The Study of the Liver (APASL 2018), New Delhi, India, 14-18 March 2018. Hepatology International. 2018, 12 (Suppl 2): S517. |
| Younossi Z.M., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Van K.N., Lai C.L., Yuen R.M.F., Chan H.L.Y. and Lai W., Health-Related Quality of Life (HRQL) in East Asian Patients with Hepatitis C Virus (HCV) Infection: The Impact of Treatment and Sustained Virologic Response (SVR), Hepatology. 2017, 66: 395A-396A. |
| Younossi Z.M., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Nguyen V.A.N. .K., Lai C.L., Yuen R.M.F., Chan H.Y.L. and Lai W., Health-Related Quality of Life (HRQL) in East Asian Patients with Hepatitis C Virus (HCV) Infection: The Impact of Treatment and Sustained Virologic Response (SVR), Poster presentation at the 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017, Washington DC, USA, 20-24 October 2017. 66 (Suppl 1): 395A. |
| Yuen R.M.F., Clinical advances in treatment of chronic hepatitis B, Singapore Hepatitis Conference, Singapore, 7 - 9 June. 2018. |
| Yuen R.M.F., Clinical application of HBV markers, Guangdong-Hongkong Hepatology Conference, Guangzhou, China, 26 August. 2017. |
| Yuen R.M.F., Doctor of Science, The University of Hong Kong. 2017. |
| Yuen R.M.F., Elkashab M., Chen C.Y., Coffin C., Fung S., Greenbloom S., Jang J.W., Jeng R.W.J., Kim D.J., Kim Y.J., Kim W., Lee K.S., Lim Y.S., Ramji A., Iyer R., Macfarlane C., Jackson K., Locarnini S., Afdhal N. and Chan H., Dose response and safety of the daily, oral RIG-I agonist Inarigivir (SB 9200) in treatment naïve patients with chronic hepatitis B: results from the 25mg and 50mg cohorts in the ACHIEVE trial, Journal of Hepatology. 2018, 68: S509-S510. |
| Yuen R.M.F., Faculty Knowledge Exchange (KE) Award, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018. |
| Yuen R.M.F., Global epidemiology of hepatocellular carcinoma, Annual meeting, American Society of Clinical Onoclogy, Chicago, USA, 4 June. 2018. |
| Yuen R.M.F., HBeAg negative chronic hepatitis B on antiviral therapy: lifelong or finite duration/ on-demand, Annual meeting, Asian Pacific Association for the Study of the Liver (APASL), New Dehli, India, 14 – 18 March. 2018. |
| Yuen R.M.F., Hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection, The 54th Annual Meeting of Japan Society of Hepatology, Osaka, Japan, 15 June. 2018. |
| Yuen R.M.F., Chen D.S., Dusheiko G.M., Janssen H.L.A., Lau D.T.Y., Locarnini S.A., Peters M.G. and Yuen R.M.F., Hepatitis B virus infection, Nature Reviews Disease Primers. 2018, 4: 18035. |
| Yuen R.M.F., Hepatitis B virus – hepatocellular carcinoma lunch case discussion, Singapore Hepatitis Conference, Singapore, 7 - 9 June. 2018. |
| Yuen R.M.F., Improving long-term outcomes for patients with HBV: looking to the future, Hepatology in Asia 2017, Hong Kong, 2 December. 2017. |
| Yuen R.M.F., Agarwal K., Gane E., Schwabe C., Cheng W., Sievert W., Kim D.J., Ahn S.H., Lim Y.S., Visvanathan K., Ruby E., Liaw S., Colonno R. and Lopatin U., Interim safety, tolerability pharmacokinetics, and antiviral activity of ABI-H0731, a novel core protein allosteric modulator, in healthy volunteers and non-cirrhotic viremic subjects with chronic hepatitis B, Poster Presentation at the International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018. 68: S111. |
| Yuen R.M.F., Management of difficult to treat cases HBV and HCC – Panelist, Singapore Hepatitis Conference, Singapore, 7 - 9 June. 2018. |
| Yuen R.M.F., Member, HBV Forum. 2018. |
| Yuen R.M.F., Member, International Coalition to Eliminate HBV (ICE-HBV). 2017. |
| Yuen R.M.F., Novel circulating markers for HBV infection or cccDNA, Annual meeting, Taiwan Association for the Study of Liver (TASL), Kaohsiung, Taiwan, 9 – 10 December. 2017. |
| Yuen R.M.F., Occult hepatitis B infection, Asian Pacific Digestive Disease Week, Hong Kong, 25 September. 2017. |
| Yuen R.M.F., Overview of hepatitis B virus molecular virology – unsolved issues and new drug (target), Postgraduate course, Single Topic Conference, HBV Asian Pacific Association for the Study of the Liver (APASL), Taipei, Taiwan, 22 – 24 June. 2018. |
| Yuen R.M.F., Practical guide for performing studies and writing up papers, Clinical Research Topic Sharing, New Territories West Cluster, Hong Kong, 6 October. 2017. |
| Yuen R.M.F., Prevention of hepatitis B reactivation, 21st General Meeting of Japan Society of Hepatology, Japan Digestive Disease Week 2017, Fukuoka, Japan,12 – 15 October. 2017. |
| Yuen R.M.F., Liu S.H.K., Given B., Schluep T., Hamilton J., Lai C.L., Locarnini S., Jackson K., Lai J.Y., Ferrari C. and Gish R.G..., RNA interference therapy with ARC-520 Injection results in long term off-therapy antigen reductions in treatment naïve, HBeAg positive and negative patients with chronic HBV, Poster Presentation at The International Liver Congress 2018, (EASL), Paris, France, 11–15 April 2018. Journal of Hepatology. 2018, 68: S526. |
| Yuen R.M.F., Recent development of capsid modulators/ inhibitors as new antiviral agents, Plenary Session, Single Topic Conference, HBV Asian Pacific Association for the Study of the Liver (APASL), Taipei, Taiwan, 22 – 24 June. 2018. |
| Yuen R.M.F., Role of hepatitis B core-related antigen (HBcrAg) on chronic hepatitis B, Annual meeting, State Key Laboratory of Liver Research, July. 2017. |
| Yuen R.M.F., Coffin C.S., Elkhashab M., Greenbloom S., Ramji A., Chan H.L.Y., Iyer R.P., Locarnini S., Macfarlane C., Afdhal N.H. and Kim W., SB 9200 an oral selective immunomodulator is safe and efficacious in treatment-naive, non-cirrhotic HBV patients: Results from Cohort 1 of the ACHIEVE trial, Hepatology. 2017, 66: 22A. |
| Yuen R.M.F., Screening, enhancement of access to care and prioritization of treatment for chronic hepatitis C infection in high-risk populations in Hong Kong 2018-2020, Gilead Sciences, USA. 2018. |
| Yuen R.M.F., The road ahead – will novel HBV treatments enter clinics soon?, International Liver Congress, European Association for the Study of the Liver, Paris, France, 14 April 2018. 2018. |
| Yuen R.M.F., Towards cure: remaining challenges in Asian Pacific region, Sympomium, Single Topic Conference, HBV Asian Pacific Association for the Study of the Liver (APASL), Taipei, Taiwan, 22 – 24 June. 2018. |
| Yuen R.M.F., Understanding hepatitis B virus disease in 2017, Noval Approaches in Medicine – Where are we in 21st century, Hong Kong, 18 – 19 November. 2017. |
| Yuen R.M.F., Updates on hepatitis C management, The Society of Hospital Pharmacists of Hong Kong, Hong Kong, 22 September. 2017. |
| Yuen R.M.F., Keynote Lecture: Prevention of hepatitis B reactivation, 21st General Meeting of the Japan Society of Hepatology, Japan Digestive Disease Week 2017, 12-15 October 2017, Fukuoka, Japan. 2017. |
| Researcher : Yung SSY |
| Project Title: | Fibronectin fragments and isoforms in the pathogenesis of tubulo-interstitial damage in lupus nephritis |
| Investigator(s): | Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 12/2017 |
| Project Title: | The Role of miR-200c in Peritoneal Inflammation and Fibrosis |
| Investigator(s): | Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Persistent peritoneal inflammation and its effect on peritoneal fibrosis |
| Investigator(s): | Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Completion Date: | 04/2018 |
| Project Title: | The role of Extra Domain A Fibronectin in Peritoneal Fibrosis |
| Investigator(s): | Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | American Society of Nephrology Kidney Week 2017; Binding of Anti-dsDNA Antibodies to Major Vault Protein of Proximal Renal Tubular Epithelial Cells Resulted in Increased Fibronectin Expression and MCP-1 Secretion |
| Investigator(s): | Yung SSY |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2017 |
| Completion Date: | 11/2017 |
| Project Title: | The role of Decorin in Peritoneal Inflammation and Fibrosis |
| Investigator(s): | Yung SSY, Chan DTM |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Ma J., KALA S., Yung S.S.Y., Chan D.T.M., Cao Y., Jiang Y., Liu X., Giorgio S., Peng L. and Wong A.S.T., Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70 S6K with Dendrimer Nanovector-Based siRNA Delivery, Molecular Therapy. 2018, 26: 70-83. |
| Ma M.K.M., Yung S.S.Y. and Chan D.T.M., mTOR inhibition and kidney diseases, Transplantation. 2018, 102: S32-40. |
| Yap Y.H.D., Thong K.M., Yung S.S.Y., Tang C., Ma B.M. and Chan D.T.M., Antiphospholipid antibodies in lupus nephritis – a single centre experience, 55th ERA-EDTA Congress 2018, Copenhagen, Denmark. 2018. |
| Yap Y.H.D., Tang C.S.O., Lee P., Tam C., Yam I., Yung S.S.Y. and Chan D.T.M., Relationship between B cell signatures and disease flare in lupus nephritis patients, American Society of Nephrology Kidney Week 2017, New Orleans USA. 2017. |
| Yung S.S.Y., Chu J.Y.S., Chau K.M., Cheung K.F. and Chan D.T.M., MicroRNA-200c Inhibits TGF-beta1-induced Epithelial-to-mesenchymal Transition and Fibrogenesis in Human Peritoneal Mesothelial Cells, UK Kidney Week 2017. |
| Yung S.S.Y., miRNA, EMT and Fibrosis, 17th Congress of the International Society for Peritoneal Dialysis. 2018. |
| Yung S.S.Y., microRNA-200c Attenuates TGF-beta1-induced Epithelial-to-mesenchymal Transition and Matrix Protein Deposition in Human Peritoneal Mesothelial Cells, 17th Congress of the International Society for Peritoneal Dialysis. 2018. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| LI X., Michaeloudes C., Zhang Y., Wiegman C.H., Adcock I.M., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K.F., Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, Journal of Allergy and Clinical Immunology. 2018, 141: 1634-1645. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : ZHANG Z |
| List of Research Outputs |
| Yu Z., Tang P.L., Wang J., Bao S., Shieh J.T., Leung A.W., ZHANG Z., Gao F., Wong S.Y., Hui A.L., Gao Y., Dung W.F., ZHANG Z., Fan Y., Zhou X., ZHANG Y., Wong S.M., Sham P.C., Azhar A., Kwok P.Y., Tam P.P., Lian Q., Cheah K.S.E., Wang B. and Song Y., Mutations in Hnrnpa1 cause congenital heart defects, In: Howard A. Rockman, JCI insight. the American Society for Clinical Investigation (ASCI), 2018, 3. |
| ZHANG Z., Zhang Y., Gao F., HAN S., Cheah K.S.E., Tse H.F. and Lian Q., CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects, Molecular Therapy - Nucleic Acids. 2017, 9: 230-241. |
| Researcher : ZHEN Z |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Tanabe Y., Liao S., Zhen Z. and Tse H.F., High-performance wireless powering for peripheral nerve neuromodulation systems, PLOS ONE. 2017, 12: e0186698. |
| WANG Y., ZHEN Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., A case-control study on periodontitis and left ventricular function in patients with diabetes, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD156. |
| WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Pelekos G., Tonetti M. and Jin L., Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients, Journal of Clinical Periodontology. 2017, 44: 1253-1263. |
| ZHAO D., Yiu K.H., Zhen Z., Pelekos G., Tonetti M. and Jin L., Oral/periodontal conditions are closely associated with general health status and comorbidity profiles, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD128. |
| Researcher : ZHU H |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| ZHU H. and Hung F.N.I., Administration of mBD4 reduced A (H1N1)09virus replication in obese mice respiratory tract, Medical Research Conference 2018 (Poster presentation). 2018. |
| ZHU H. and Hung F.N.I., Mouse beta-defensin 4 limits A(H1N1)09 influenza virus replication in respiratory tract of senescent mice, Medical Research Conference 2018 (Oral Presentation). 2018. |
| Researcher : Zhang J |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| Researcher : Zhang Q |
| List of Research Outputs |
| Chan D.T.M., Au K.Y., Cheung K.F., Zhang Q., Chau K.M. and Yung S.S.Y., Circulating Lipopolysaccharide, Lipopolysaccharide Binding Protein and CD14 Levels in Lupus Nephritis, UK Kidney Week 2017. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| LI X., Michaeloudes C., Zhang Y., Wiegman C.H., Adcock I.M., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K.F., Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, Journal of Allergy and Clinical Immunology. 2018, 141: 1634-1645. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Wu H., Yiu W.H., Wong W.L.D., Li R.X., Chan Y.Y., Leung J.C.K., Zhang Y., Lian Q., Lai K.N., Tang S.C.W. and Tse H.F., Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Adriamycin Nephropathy in Mice, Oncotarget (in press). 2017, 2017. |
| ZHANG Y., CHIU S.M., LIANG X., Chai Y.H., Wang J., Li X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection., Exp Cell Res. 2017. 2017, 356(1): 74-84. |
| Researcher : Zhen Z |
| List of Research Outputs |
| CHEN Y., Liu J., Au W.I.N.G. .K.O.K., ZHEN Z., Yap Y.H.D., Lau C.P., Tse H.F. and Yiu K.H., Cardiorenal syndrome in patients with valvular heart disease, European Society of Cardiology, ESC Congress Aug 26-30, 2017. |
| Chen Y., LIU J.H., Zhen Z., Tse H.F. and Yiu K.H., Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension, Journal of Investigative Medicine. 2018, 66: 319-324. |
| Han Q., Li G., Ip M.S.M., Zhang Y., Zhen Z., Mak J.C.W. and Zhang N., Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission, Journal of Cellular and Molecular Medicine. 2018, 22: 2717-2726. |
| Liang Y., LI X., Zhang Y., Yeung S.C., ZHEN Z., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction, Frontiers in Pharmacology. 2017, 8: 501. |
| Liu J., CHEN Y., ZHEN Z., Ho L.M., Tsang A., Yuen M.A.M., Lam K.S.L., Tse H.F. and Yiu K.H., Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus., Biomark Med. 2017, 11(7): 569-578. |
| Tanabe Y., Liao S., Zhen Z. and Tse H.F., High-performance wireless powering for peripheral nerve neuromodulation systems, PLOS ONE. 2017, 12: e0186698. |
| WANG Y., ZHEN Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., A case-control study on periodontitis and left ventricular function in patients with diabetes, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD156. |
| WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Pelekos G., Tonetti M. and Jin L., Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients, Journal of Clinical Periodontology. 2017, 44: 1253-1263. |
| ZHAO D., Yiu K.H., Zhen Z., Pelekos G., Tonetti M. and Jin L., Oral/periodontal conditions are closely associated with general health status and comorbidity profiles, EuroPerio 9, June 20-23, Amsterdam, The Netherlands. 2018, PD128. |
| Researcher : Zhong L |
| Project Title: | Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of hepatic cholesterol metabolism |
| Investigator(s): | Zhong L, Woo WHC, Xu A, Chan CP |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2017 |
| List of Research Outputs |
| Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6. |
| JI X., Zhou P., Zhong L., Xu A., Tsang C.O.A. and Chan K.L., Smart surgical catheter for C-reactive protein sensing based on an imperceptible organic transistor, Advanced Science. 2018, Epub on 2018-05-03. |
| Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018. |
| Shu L., Zhong L., Xiao Y., Hoo R.L.C. and Xu A., Pharmacological Inhibition of Neutrophil Elastase Attenuates Insulitis &Autoimmune Diabetes in Mice , American Diabetes Association 78th Scientific sessions . 2018. |
| Researcher : Zhou P |
| List of Research Outputs |
| JI X., Zhou P., Zhong L., Xu A., Tsang C.O.A. and Chan K.L., Smart surgical catheter for C-reactive protein sensing based on an imperceptible organic transistor, Advanced Science. 2018, Epub on 2018-05-03. |
| Researcher : Zhu CF |
| Project Title: | Deciphering the role of adipose tissue inflammation and adipokines in gut microbiota-induced systemic insulin resistance and metabolic dysregulation |
| Investigator(s): | Zhu CF, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | IUNS 21st International Congress of Nutrition (ICN); Role of fatty acid binding Protein 4 as an adipokine to regulation bone resorption during postmenopause osteoporosis mice fed by high fat diet |
| Investigator(s): | Zhu CF |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2017 |
| List of Research Outputs |
| Zhu C.F., Zhang W., Mu B., Zhang F., Lai N.N., Zhou J.X., Xu A., Liu J.G. and Li Y., Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats, Journal of Food Science and Technology. 2017, 54: 2260-2269. |
| Zhu C.F., Zhang W., Liu J.G., Mu B., zhang F., Lai N.N., Zhou J.X., Xu A. and Li Y., Marine Collagen Peptides Reduce Endothelial Cell Injury In Diabetic Rats By Inhibiting Apoptosis And The Expression Of Coupling Factor 6 And Microparticles, Molecular Medicine Reports. 2017, 16: 3947-3957. |
| Zhu C.F., 肠道菌群基因多态性与绝经后骨质疏松症的相关性研究, 深圳市宝安区科创委基础研究基金, 2017. |
| Zhu C.F., 深圳市科技计划项目医疗卫生类, 深圳市卫计委, 2017. |
| Zhu C.F., 雌激素-肠道菌群-Orexin A/B 调控机体脂肪细胞能量代谢/肥胖症的机制研究, 深圳市科创委基础研究（自由探索）, 2017. |
| Researcher : Zhu H |
| List of Research Outputs |
| Lee C.Y., To K.K.W., Zhang J., Zhu H., Li C., Zhang R., Hung F.N.I., Kao R.Y.T., Chan K.H. and Yuen K.Y., Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice, Archives of Virology. 2018, 163(9): 2349-2358. |
| ZHU H. and Hung F.N.I., Administration of mBD4 reduced A (H1N1)09virus replication in obese mice respiratory tract, Medical Research Conference 2018 (Poster presentation). 2018. |
| ZHU H. and Hung F.N.I., Mouse beta-defensin 4 limits A(H1N1)09 influenza virus replication in respiratory tract of senescent mice, Medical Research Conference 2018 (Oral Presentation). 2018. |