Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au LKS

List of Research Outputs

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Researcher : Au YLE

List of Research Outputs

Au Y.L.E., Sou Da Rosa Duque J., Lau W.C.S. and Chan Y.T.E., A patient with anaphylaxis to diphenhydramine without cross-reactivity to loratadine, The Journal of Allergy and Clinical Immunology: In Practice. 2018, 6: 1061-1063.

Researcher : Au Yeung KHR

Project Title:	The role of SOX9 in mature B and T cell lymphomas
Investigator(s):	Au Yeung KHR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	The epidemiology, clinicopathologic features, and treatment outcome of double-hit B-cell lymphomas
Investigator(s):	Au Yeung KHR, Kwong YL, Khong PL
Department:	Pathology
Source(s) of Funding:	The Hong Kong College of Pathologists
Start Date:	07/2017

List of Research Outputs

Hwang Y.Y.G., Au Yeung K.H.R., Lau H.P. and Kwong Y.L., Complete response of age-related Epstein-Barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide, Annals of Hematology. 2018, 97: 363-366.

Reddy A., Zhang J., Davis N.S., Moffitt A.B., Love C.L., Waldrop A., Leppa S., Pasanen A., Meriranta L., Karjalainen-Lindsberg M.L., Nørgaard P., Pedersen M., Gang A.O., Høgdall E., Heavican T.B., Lone W., iqbal J., Qin Q., Li G., Kim S.Y., Healy J., Richards K.L., Fedoriw Y., Bernal-Mizrachi L., Koff J.L., Staton A.D., Flowers C.R., Paltiel O., Goldschmidt N., Calaminici M., Clear A., Gribben J., Nguyen E., Czader M.B., Ondrejka S.L., Collie A., Hsi E.D., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Choi W.L., Evens A.M., Pilichowska M., Sengar M., Reddy N., Li S., Chadburn A., Gordon L.I., Jaffe E.S., Levy S., Rempel R., Tzeng T., Happ L.E., Dave T., Rajagopalan D., Datta J., dunson D.B. and Dave S.S., Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma, Cell. 2017, 171: 481-494.e15.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung E.T.K., Au Yeung K.H.R., Cai J., Chong K.E.N. .T.K., Sze K.H., Kao R.Y.T., Hao Q. and Yuen K.Y., Mp1p Homologues As Virulence Factors In Aspergillus Fumigatus, Medical Mycology. 2018, 56: 350-360.

Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966.

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Beh S.L., Elderly Abuse - A Neglected But Increasing Problem, 24th Congress Of The International Academy Of Legal Medicine. 2018.

Beh S.L., The Development Of Forensic Medicine In Hong Kong, In: Burkhard Madea, History Of Forensic Medicine. Berlin, Germany, Lehmanns Media, 2017.

Researcher : CHAN KS

List of Research Outputs

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017.

Chan K.S. and Lo C.L.R., Deregulation Of Frizzled Receptors In Hepatocellular Carcinoma, International Journal Of Molecular Sciences. MDPI, 2018, 19: 313.

Lo C.L.R., CHAN K.S., Chok K.S.H. and Ng I.O.L., Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre, Journal of Clinical Pathology. 2017, Epub ahead of print.

Researcher : CHEN Q

List of Research Outputs

XIAO F., Lin X., Tian J., Wang X., CHEN Q., Rui K., Ma J., Wang S., Wang Q., Wang X., Liu D., Sun L. and Lu L., Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome, Cellular & Molecular Immunology. 2017.

Researcher : CHENG YLB

List of Research Outputs

CHENG Y.L.B., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Lin C.H., Lo C.L.R., Ma S.K.Y., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Research. 2018, 78(9): 2332-2242.

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Researcher : CHIU KC

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Researcher : Chan ASY

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Chan CY

List of Research Outputs

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Researcher : Chan KK

List of Research Outputs

Chan K.K., Wong E.S.Y., Wong G.W., Ngan H.Y.S. and Cheung A.N.Y., Identification of nonsynonymous TP53 mutations in hydatidiform moles, Identification of nonsynonymous TP53 mutations in hydatidiform moles. 2018, 20-23.

Chan K.K., Wong G.W., Wong E.S.Y., Chan K.K.L., Ip P.C.P., Tse K.Y. and Cheung A.N.Y., Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma, International Journal of Cancer. 2018.

Lo C.L.R., Leung C.O., Chan K.K., Ho D.W.H., Wong C.M., Lee T.K. and Ng I.O.L., Cripto-1 activates Wnt/-catenin signaling via binding with Frizzled-7 and Disheveled 3 to regulate stemness phenotypes in hepatocellular carcinoma, Cell Death & Differentiation 2018.

Lo R.C., Chan K.K., Leung C.O. and Ng I.O.L., Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts - an immunohistochemical study, Clin Transplant . 2018.

Researcher : Chan KS

List of Research Outputs

Chan K.S. and Lo C.L.R., Deregulation Of Frizzled Receptors In Hepatocellular Carcinoma, International Journal Of Molecular Sciences. MDPI, 2018, 19: 313.

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

List of Research Outputs

Chan C.M.G., LAI K.Y., Ng E.K.O., Kiang M.N., Kwok W.H.T., Wang K.S.H., Chan K.W., Law T.T., Tong K.H.D., Chan K.T., Lee N.P.Y. and Law S.Y.K., Serum microRNA-193b as a promising biomarker for prediction of chemoradiation sensitivity in esophageal squamous cell carcinoma patients, Oncology Letters. 2017.

Chan K.W., Kwong A.S., Chan G.C., Leung C.P., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong D.W., Li B., Li Y., Feng Y., Chan L.Y., Leung J.C.K., Tan K.C.B., Wong V.C., Lai K.N. and Tang S.C.W., Semi-individualised Chinese medicine treatment for diabetic kidney disease - from users' perspectives to SCHEMATIC trial interim result and potential mechanism., Good Practice in Traditional Chinese Medicine Research Association, London.. 2017.

Dai W., Ko J.M.Y., Choi S.S.A., Yu Z., NING L., Zheng H., Gopalan V., Chan K.T., Lee N.P.Y., Chan K.W., Law S.Y.K., Lam A.K.Y. and Lung M.L., Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma, Journal of Pathology. 2017, 242(4): 500-510.

LAU C.C., Ng K.Y., Wong T.L., Tong M., Lee T.K., Ming X., Law S.Y.K., Lee N.P.Y., Cheung A., Qin Y.R., Chan K.W., Ning W., Guan X. and Ma S.K.Y., FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling crosstalk, Cancer Research. 2017, 77(21): 5886-5899.

Li B., Xu W., Han L., Chan K.T., Tsao G.S.W., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., He Q.Y. and Cheung A., MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF, Oncogene. 2017, 36(28): 3986-4000.

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan LK

List of Research Outputs

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

Liu J., Rao Y., Cheung M., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheak K., Sharma R., Hodgson L. and Cheung M., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, Nat Commun . 2017.

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2012

Researcher : Chan YK

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2010

Researcher : Chan YP

List of Research Outputs

Chan Y.P., Wong M.W.K., Tang L.W.M., GUO M., Yang W., Ip P., Li P.K.T., Leung C.B., Chau K.F., Lam J.C.K., Yeung N.K.M. and Kwok J.S.Y., A simplified method of calculating cPRA for kidney allocation application in Hong Kong: a retrospective study., Transplant International . Wiley, 2017.

Researcher : Chan YTE

List of Research Outputs

Au Y.L.E., Sou Da Rosa Duque J., Lau W.C.S. and Chan Y.T.E., A patient with anaphylaxis to diphenhydramine without cross-reactivity to loratadine, The Journal of Allergy and Clinical Immunology: In Practice. 2018, 6: 1061-1063.

Researcher : Chen SPL

List of Research Outputs

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

Researcher : Cheng LHC

List of Research Outputs

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Placental biology of Down Syndrome in relation to increased gene dosage
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	p53 related proteins and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	Nanog in ovarian cancer metabolism
Investigator(s):	Cheung ANY, Chan KK, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015
Completion Date:	11/2017

Project Title:	Molecular targets of Stem cell factor NANOG in stress responses of ovarian cancer
Investigator(s):	Cheung ANY, Wong GW, Chan KK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	p21 activated kinase 4 and ovarian cancer chemoresistance
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Oxidative phosphorylation in ovarian carcinoma and its effect on cancer stemness
Investigator(s):	Cheung ANY, Chan KK, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Characterizing the gene transcription mechanism of p21-activated kinase 4 in ovarian cancer
Investigator(s):	Cheung ANY, Wong TLI, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Chan K.K., Wong E.S.Y., Wong G.W., Ngan H.Y.S. and Cheung A.N.Y., Identification of nonsynonymous TP53 mutations in hydatidiform moles, Identification of nonsynonymous TP53 mutations in hydatidiform moles. 2018, 20-23.

Chan K.K., Wong G.W., Wong E.S.Y., Chan K.K.L., Ip P.C.P., Tse K.Y. and Cheung A.N.Y., Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma, International Journal of Cancer. 2018.

Chan K.K.L., Siu K.Y., JIANG Y., WANG J., Wang Y., Leung T.H.Y., Liu S., Cheung A.N.Y. and Ngan H.Y.S., Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis, BMC Cancer. 2017.

Cheung A.N.Y., 1) Advances in Molecular Pathology: Hong Kong Experience 2) Recent advances in gynaecological pathology, International Congress of Pathology and Laboratory Medicine 2018, 28-30 June 2018, . 2018.

Cheung A.N.Y., A pathologist’s contribution to patients with ovarian cancers: microscope and sequencer, Invited speaker in the National Pathology Conference 2017, Chinese Society of Pathology, Suzhou, 28-29th October 2017. 2017.

Cheung A.N.Y., Application of biomarker for cervical cancer identified from micro-RNA targets, 第四届全国阴道镜与宫颈病理学大会, May 24-27, 2018,Shenzhen China. 2018.

Cheung A.N.Y., Automated imager cytology screening and HPV tests, Invited speaker in Asia Oceania (research organisation on) Genital Infections & Neoplasia (AOGIN), 17-20th October 2017, Tokyo. 2017.

Cheung A.N.Y., Editorial Board Standing Member, WHO Classification of Tumours 5th edition. 2018.

Cheung A.N.Y., Impact of Genetic Testing for Ovarian Cancer patients, Invited speaker in the Cross- Strait Precision Medicine - Training Course in Molecular Pathology Diagnosis organized by the Cross Straits Association of Precision Medicine, Fuzhou, 4-6th Aug 2017, Fuzhou. 2017.

Cheung A.N.Y., Optimizing testing to enhance clinical outcome: Biomarkers of ovarian cancer, Invited speaker in The Women Cancer Symposium organized by the Breast Cancer Foundation, 19th August 2017, Hong Kong. 2017.

Cheung A.N.Y., Precision Medicine in Gynaecological Diseases, Invited speaker in 2017 Conference on Quality Control in Pathology Diagnosis and Training Course on Structured Diagnosis of Tumour Pathology, Shenzhen, 14th October 2017. 2017.

Cheung A.N.Y., Role of Pathologist in Lymph Node Assessment for Patients with Endometrial Cancer, Hospital Authority Convention 2018, 7-8 May 2018, Hong Kong. 2018.

Cheung A.N.Y., Targeting concerted signaling proteins for synergistic lethality by combinatorial therapy against cancer, 2nd annual meeting of the international society of precision cancer medicine (ISPCM), 15-19th of March, 2018, Busan, Korea. 2018.

Ip P.C.P., Lim D., Cheung A.N.Y. and Oliva E., Immunoexpression of p16 in uterine leiomyomas with infarct-type necrosis: an analysis of 35 cases, Histopathology. 2017.

LI X., Mak C.Y., Zhou Y., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., PIK3R1 loss activates AKT and STAT3 signaling in ovarian cancer, American Association of Cancer Research Annual Meeting 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., PIK3R1 loss predicts sensitivity to AKT and STAT3 inhibitors in ovarian cancer, 2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2018.

LI X., Mak C.Y., Cheung A.N.Y. and Cheung W.T.L., Targeting PIK3R1 loss by AKT and STAT3 inhibitors in ovarian cancer, 13th International Symposium on Healthy Aging. 2018.

Leung T.H.Y., Tang W.M., Siu K.Y., Chan D.W., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., HPV-E6 protein enriches the CD55(+) population in cervical cancer cells promoting radio-resistance and cancer aggressiveness, The Journal of Pathology. 2017.

Meng Y., Chen C.W., Yung M.H., Sun W., Sun J., Li Z., Li J., Li Z., Zhou W., Liu S., Cheung A.N.Y., Ngan H.Y.S., Braisted J.C., Kai Y., Peng W., Tzatsos A., Li Y., Dai Z., Zheng W., Chan D.W. and Zhu W., DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer, Cancer Letters. 2018.

Ngu S.F., Chu M.Y.M., Tse K.Y., Chan K.K.L., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Role Of Lymphadenectomy And Vincristine, Actinomycin-D, and Cyclophosphamide Chemotherapy in Malignant Ovarian Germ Cell Tumors, European Journal of Gynaecological Oncology. 2018, 39(1): 63-69.

Tse K.Y., Chiu W.H.K., Chan K.K.L., Chu M.Y.M., Ngu S.F., Cheung A.N.Y., Ngan H.Y.S. and Ip P.C.P., A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors, American Journal of Clinical Pathology. 2018.

Wong G.W., Ho M.W., Tsun O.K.L., Ng A.K., Tsui E.Y., Chow J.N., Ip P.C.P. and Cheung A.N.Y., An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity, Cytopathology. 2018, 29: 267-274.

Zhou W., Sun W., Yung M.H., Dai S., Cai Y., Chen C.W., Meng Y., Lee J.B., Braisted J.C., Xu Y., Southall N.T., Shinn P., Huang X., Song Z., Chen X., Kai Y., Cai X., Li Z., Hao Q., Cheung A.N.Y., Ngan H.Y.S., Liu S., Barak S., Hao J., Dai Z., Tzatsos A., Peng W., Pei H., Han Z., Chan D.W., Zheng W. and Zhu W., Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance, Oncogene. 2018.

Researcher : Cheung YN

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2010

Researcher : Ching DCK

List of Research Outputs

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP, Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015
Completion Date:	12/2018

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Characterization of novel HBx regulated gene in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	A study of the regulation of TAX1 binding protein 2 by p21-activated protein kinase 4 in liver cancer metastasis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2017

Project Title:	15th Annual Congress of International Drug Discovery Science and Technlogy ; The role of centrosome over-duplication in liver cancer
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2017
Completion Date:	07/2017

Project Title:	Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Investigator(s):	Ching YP, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Molecular mechanisms of Pumilio-Regulated Chromosomal Instability in Hepatocellular Carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Researcher : Chiu KC

Project Title:	AACR Annual Meeting 2018; HEY1 counteracts hypoxia-induced oxidative stress via transcriptionally repressing PINK1 in hepatocellular carcinoma
Investigator(s):	Chiu KC
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Researcher : Chiu YT

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Choi WL

Project Title:	Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):	Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:	Pathology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	04/2011

List of Research Outputs

Reddy A., Zhang J., Davis N.S., Moffitt A.B., Love C.L., Waldrop A., Leppa S., Pasanen A., Meriranta L., Karjalainen-Lindsberg M.L., Nørgaard P., Pedersen M., Gang A.O., Høgdall E., Heavican T.B., Lone W., iqbal J., Qin Q., Li G., Kim S.Y., Healy J., Richards K.L., Fedoriw Y., Bernal-Mizrachi L., Koff J.L., Staton A.D., Flowers C.R., Paltiel O., Goldschmidt N., Calaminici M., Clear A., Gribben J., Nguyen E., Czader M.B., Ondrejka S.L., Collie A., Hsi E.D., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Choi W.L., Evens A.M., Pilichowska M., Sengar M., Reddy N., Li S., Chadburn A., Gordon L.I., Jaffe E.S., Levy S., Rempel R., Tzeng T., Happ L.E., Dave T., Rajagopalan D., Datta J., dunson D.B. and Dave S.S., Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma, Cell. 2017, 171: 481-494.e15.

Researcher : Cui D

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Researcher : DU W

List of Research Outputs

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Researcher : GAO X

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

WANG S., Xiao Z., Tin P.C., GAO X. and Wong M.P., Stress response through theCaMK2A/NRF2/GSTP1 axis strengthens cancer cell resilience and mediates stemness phenotype through ROS attenuation, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : Ho DWH

Project Title:	Investigation of functional synergism of CENPF and FOXM1 in hepatocellular carcinoma
Investigator(s):	Ho DWH, Ng IOL, Chan LK, Kai AKL, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	01/2019

List of Research Outputs

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Ho D.W.H. and Ng I.O.L., TCGA whole-exome sequencing data reveals mutational parameters in distinguishing potential cancer drivers, Human Genome Meeting 2018.

Lo C.L.R., Leung C.O., Chan K.K., Ho D.W.H., Wong C.M., Lee T.K. and Ng I.O.L., Cripto-1 activates Wnt/-catenin signaling via binding with Frizzled-7 and Disheveled 3 to regulate stemness phenotypes in hepatocellular carcinoma, Cell Death & Differentiation 2018.

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Ho RSL

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Huang F

Project Title:	In vivo tracking & visualizing the IL-10-producing regulatory B cells induced & expanded by IL-33 (BregIL-33), & following adoptive transfer of the BregIL-33 into IL-10-deficient mice
Investigator(s):	Huang F
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	07/2017

List of Research Outputs

Lam K.Y.I., Xiao Z., Tin P.C., Huang F. and Wong M.P., NFATc2 in non-small cell lung cancer mediates inhibition of peripheral blood mononuclear cell proliferation, 110th Annual Meeting of the American Association for Cancer Research. 2017.

Researcher : Ip HW

List of Research Outputs

Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017.

Singh G.H.H., Yim R.L.H., Lee H.K.K., Mak V., Lin S.Y., Kho B., Yip S.F., Lau J.S.M., Li W., Ip H.W., Hwang Y.Y.G., Chan S.Y.T., Tse E.W.C., Au W.Y., Kumana C.R. and Kwong Y.L., Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study, Cancer. 2018.

Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017.

Researcher : Ip PCP

Project Title:	Examining PD-L 1 status in genital tract melanomas
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	Bristol-Myers Squibb Pharma (HK) Ltd.
Start Date:	02/2017

Project Title:	Pathogenetic mechanisms of female genital tract malignant melanoma
Investigator(s):	Ip PCP, Tsang TY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	2018 Annual Meeting of United States and Canadian Academy of Pathology; Female genital melanomas: A clinicopathologic and PD-L1 expression study
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2018
Completion Date:	03/2018

List of Research Outputs

Chan K.K., Wong G.W., Wong E.S.Y., Chan K.K.L., Ip P.C.P., Tse K.Y. and Cheung A.N.Y., Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma, International Journal of Cancer. 2018.

Cho K.R., Cooper K., Croce S., Djordevic B., Herrington S., Howitt B., Hui P., Ip P.C.P., Koebel M., Lax S., Quade B.J., Shaw P., Vidal A., Yemelyanova A., Clarke B., Hedrick Ellenson L., Longacre T.A., Shih I.M., McCluggage W.G., Malpica A., Oliva E., Parkash V. and Matias-Guiu X., International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project, International Journal of Gynecological Pathology. 2018, 1.

Ip P.C.P., Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens, Virchows Archiv. 2018, 472: 907-917.

Ip P.C.P., Editorial Board, In: Kari J. Syrjänen, Acta Cytologica. Karger, 2018.

Ip P.C.P., Editorial Board, In: Lora Hedrick Ellenson, M.D., International Journal of Gynaecological Pathology. USA, Lippincott Williams & Wilkins, 2017.

Ip P.C.P., Editorial Board, In: Lora Hedrick Ellenson, M.D., International Journal of Gynaecological Pathology. USA, Lippincott Williams & Wilkins, 2018.

Ip P.C.P., YU Y., Cheung C.L., Cheuk W., Cheung E., Wong W.C., Lee V., Chan W.K. and Tse K.Y., Female Genital melanomas: A clinicopathologic and PD-L1 expression study, The United States and Canadian Academy of Pathology 107th Annual Meeting . 2018.

Ip P.C.P., Lim D., Cheung A.N.Y. and Oliva E., Immunoexpression of p16 in uterine leiomyomas with infarct-type necrosis: an analysis of 35 cases, Histopathology. 2017.

Ip P.C.P., Invited reviewer, Histopathology. Wiley, 2018.

Ngu S.F., Chu M.Y.M., Tse K.Y., Chan K.K.L., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Role Of Lymphadenectomy And Vincristine, Actinomycin-D, and Cyclophosphamide Chemotherapy in Malignant Ovarian Germ Cell Tumors, European Journal of Gynaecological Oncology. 2018, 39(1): 63-69.

Tse K.Y., Chiu W.H.K., Chan K.K.L., Chu M.Y.M., Ngu S.F., Cheung A.N.Y., Ngan H.Y.S. and Ip P.C.P., A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors, American Journal of Clinical Pathology. 2018.

Wong G.W., Ho M.W., Tsun O.K.L., Ng A.K., Tsui E.Y., Chow J.N., Ip P.C.P. and Cheung A.N.Y., An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity, Cytopathology. 2018, 29: 267-274.

Researcher : Ip PPC

Project Title:	Examining PD-L 1 status in genital tract melanomas
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	Bristol-Myers Squibb Pharma (HK) Ltd.
Start Date:	02/2017

Project Title:	Pathogenetic mechanisms of female genital tract malignant melanoma
Investigator(s):	Ip PCP, Tsang TY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	2018 Annual Meeting of United States and Canadian Academy of Pathology; Female genital melanomas: A clinicopathologic and PD-L1 expression study
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2018
Completion Date:	03/2018

List of Research Outputs

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals
Investigator(s):	Khoo US, Leung TW, Luk MY, Yeung MWR
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2013

Project Title:	The regulatory effect of a novel splice variant, BQ323636.1, on ERα transcriptional activity facilitates the development of tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Tang MKP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	02/2018

Project Title:	The role of BQ, a novel splice variant of NCOR2 in the NRF2 antioxidant pathway
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	07/2015
Completion Date:	06/2018

Project Title:	Cardiac pacemaker channels modulating autophagy, cell senescence and apoptosis in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Testing Ivabradine on Patient Derived Xenografts: A Novel Potential Targeted Treatment for Breast Cancer
Investigator(s):	Khoo US, Tsoi H, Kwong A, Siu DCW
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	02/2017

Project Title:	Testing Ivabradine On Patient Derived Xenografts: A Novel Potential Targeted Treatment For Breast Cancer
Investigator(s):	Khoo US, Tsoi H, Kwong A
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	02/2017

Project Title:	Identifying Splicosome gene alterations associated with Tamoxifen resistance in Breast Cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target.
Investigator(s):	Khoo US, Tsoi H
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

Project Title:	Testing Ivabradine On Patient Derived Xenografts: A Novel Potential Targeted Treatment For Breast Cancer
Investigator(s):	Khoo US, Tsoi H, Kwong A, Siu DCW
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2018

Project Title:	The feasibility of using BQ323636.1, a novel splice variant of NCOR2, as a biomarker for predicting treatment response of aromatase inhibitor in ER+ve breast cancer patients
Investigator(s):	Khoo US, Tsoi H
Department:	Pathology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2018

Project Title:	Identifying interacting proteins to BQ, a novel splice variant of NCOR2 that could modulate its competition with NCOR2 in Androgen-receptor positive breast cancer
Investigator(s):	Khoo US, Tsoi H
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

List of Research Outputs

Gong C., Man P.S., Tsoi H., Lee T.K.W., Lee P., Ma S.T., Wong L.S., Luk M.Y., Rakha E.A., Green A.R., Ellis I.O., Lam E.W.F., Cheung K.L. and Khoo U.S., BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer, Clinical Cancer Research. 2018.

Khoo U.S., Splice Variant As Genomic Biomarker In Tamoxifen Resistance., 8th Seoul Breast Cancer Symposium, Seoul. 2018.. 2018.

Khoo U.S., Splice Variant as Genomic Biomarker in Tamoxifen Resistance., 8th Seoul Breast Cancer Symposium, Seoul. 2018.

Leung M.H., Tsoi H., Man P.S., Lam E.W.F. and Khoo U.S., The role of BQ323636.1, a novel splice variant of NCOR2, in modulation of oxidative stress in breast cancer, AACR Advances in Breast Cancer Research Special Conference, Hollywood, California. 2017.

Tsoi H., MOK K.C., Man P.S., Chou K.M. and Khoo U.S., KPNA1 mediates the nuclear import of BQ323636.1 and confer tamoxifen resistance in breast cancer cells. , 109th Annual Meeting for the American Association for Cancer Research, Chicago, Illinois. 2018.

Yan M., Wang Y., Wong C.W., Or P.M., Wong K.L., Li L., Many A.M., Guan H., Khoo U.S. and Chan A.M., PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model. , Cancer Lett.. 2018.

Researcher : Ko FCF

Project Title:	Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Researcher : Koh HY

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Researcher : Kwok JSY

List of Research Outputs

Chan Y.P., Wong M.W.K., Tang L.W.M., GUO M., Yang W., Ip P., Li P.K.T., Leung C.B., Chau K.F., Lam J.C.K., Yeung N.K.M. and Kwok J.S.Y., A simplified method of calculating cPRA for kidney allocation application in Hong Kong: a retrospective study., Transplant International . Wiley, 2017.

Kwok J.S.Y., GUO M., Yang W., Ip P., Chan G.C.F., Ho J., Lee C.K., Middleton D. and Lu L., Estimation of optimal donor number in Bone Marrow Donor Registry: Hong Kong’s experience, Human Immunology. Elsevier Inc, 2017.

Researcher : LAI KH

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Researcher : Lai CWJ

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Lai JCC

List of Research Outputs

Chan R.W.Y., Chan L.Y., Mok K.P., Lai J.C.C., Tao K.P., Obadan A., Chan M.C.W., Perez D.R., Peiris J.S.M. and Nicholls J.M., Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release, Scientific Reports. 2017, 7(1): 6208.

Researcher : Lam AKY

List of Research Outputs

Dai W., Ko J.M.Y., Choi S.S.A., Yu Z., NING L., Zheng H., Gopalan V., Chan K.T., Lee N.P.Y., Chan K.W., Law S.Y.K., Lam A.K.Y. and Lung M.L., Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma, Journal of Pathology. 2017, 242(4): 500-510.

Researcher : Lam CCK

List of Research Outputs

Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017.

Researcher : Lam CW

Project Title:	Food
Investigator(s):	Lam CW, Wang M
Department:	Pathology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Undiagnosed diseases program for ending diagnostic odyssey
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2014
Completion Date:	10/2017

Project Title:	Regulatory signatures of two novel prognostic metabotypes of lung adenocarcinomas: integrated analysis of transcriptomics and metabonomics of malignant pleural effusions
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Clinical application of pleural fluid fatty acid synthase and pleural fluid total free fatty acids as cancer biomarkers in malignant pleural effusions
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	06/2017

List of Research Outputs

Lam C.W., How to maintain the quality of a journal?, LMCE 2017 and KSLM 58th Annual Meeting, Oct 18-20, 2017, Seoul, Korea. 2017.

Lam C.W., Pleural Fluid Markers For Malignant Pleural Effusions, In: Lam Ching-Wan, United States Patent and Trademark Office. 2017.

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520.

Researcher : Lam KYI

List of Research Outputs

Lam K.Y.I., Xiao Z., Tin P.C., Huang F. and Wong M.P., NFATc2 in non-small cell lung cancer mediates inhibition of peripheral blood mononuclear cell proliferation, 110th Annual Meeting of the American Association for Cancer Research. 2017.

Researcher : Law CT

List of Research Outputs

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Researcher : Lee CH

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Lee D

List of Research Outputs

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Researcher : Lee E

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Lee HHC

List of Research Outputs

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Researcher : Lee JKM

List of Research Outputs

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Researcher : Lee KW

Project Title:	The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma
Investigator(s):	Lee KW, Ng IOL, Ma SKY
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	The roles of Nuclear factor (erythroid-derived 2)-like 2 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Researcher : Lee MF

List of Research Outputs

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Lee P

List of Research Outputs

Gong C., Man P.S., Tsoi H., Lee T.K.W., Lee P., Ma S.T., Wong L.S., Luk M.Y., Rakha E.A., Green A.R., Ellis I.O., Lam E.W.F., Cheung K.L. and Khoo U.S., BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer, Clinical Cancer Research. 2018.

Researcher : Leung ON

List of Research Outputs

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017.

Lo C.L.R., Leung O.N., Chok K.S.H. and Ng I.O.L., Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study, Diagnostic Pathology. 2017, 12(1): 56.

Researcher : Leung RYY

List of Research Outputs

Kwong J.H.Y., Leung R.Y.Y., Wong M.L.G., Singh G.H.H. and Kwong Y.L., Primary myelofibrosis presenting in acute promyelocytic transformation, British Journal of Haematology. 2017, 178: 349-349.

Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

Project Title:	Gastric Cancer Genomics and Beyond – Moving from Patient Samples to 3D Organoid Cultures for Integrative Genomics Analysis, Drug Sensitivity Assays, Cell Biological Studies and Animal Models
Investigator(s):	Leung SY, Zhang J, Law SYK, Ma SKY, Kwong DLW, Chan D, Ching YP, Wong SL
Department:	Pathology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2016

Project Title:	Establishing Mass Spectrometer Based Targeted Metobolomics Platform for Biomarker Validation Studies as a Core Facility
Investigator(s):	Leung SY, Boheler KR, Cheung BMY, Cheung CL, Leung AYH, Ma SKY, Rong J, Sze KH, Woo PCY, Wong CCL, Xu A
Department:	Pathology
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	Differential topological accumulation of somatic mutations in normal and cancerous gastric stem cells, and their association with gastric carcinogenesis and anti-tumour immuse response
Investigator(s):	Leung SY, Yan HHN
Department:	Pathology
Source(s) of Funding:	Kadoorie Charitable Foundation
Start Date:	03/2018

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

Leung S.Y., Exome sequencing and integrative genomic analysis identified the important role of germline and somatic RNF43 mutation in the serrated neoplasia pathway, 24th Annual Meeting of the Japanese Society for Familial Tumors, Kobe, Japan. 2018.

Leung S.Y., Gastric cancer genomics and beyond, Korea International Gastric Cancer Week 2018, Seoul, Korea. 2018.

Leung S.Y., Gastrointestinal cancer genomics – molecular subtypes and implication for precision medicine, Shanghai International Gastrointestinal Oncology Symposium, Shanghai, China. 2017.

Leung S.Y., Genetic Testing of Hereditary Gastrointestinal Cancers, Beijing Genomic Institute Hereditary Cancer Symposium, Shenzhen, China. 2018.

Leung S.Y., Genetic Testing of Hereditary Gastrointestinal Cancers, First conference on Hereditary Cancer of Guangdong Province, Guangzhou, China. 2018.

Leung S.Y., Genetic diagnosis of hereditary colorectal cancer – from Lynch Syndrome to Serrated Polyposis, Asia Pacific Digestive Week, Hong Kong. 2017.

Leung S.Y., Genetic testing of hereditary gastrointestinal cancers, Precision Oncology – protection from genetic discrimination symposium, Hong Kong. 2018.

Leung S.Y., Genomic study of adenocarcinomas arising from the gastrointestinal tract, Wellcome Trust Sanger Institute, UK. 2017.

Leung S.Y., Genomic study on molecular pathways of cancer development and its relevance to cancer precision medicine, Hospital Authority Convention Hong Kong, Hong Kong. 2018.

Leung S.Y., Genomics of gastrointestinal tract cancer, East West Alliance Alliance Symposium, Oxford, UK. 2017.

Leung S.Y., Serrated neoplasia pathway and RNF43 mutation, Gastric cancer genomics and organoid culture, Hubrecht Institute, Netherlands. 2017.

Tse H., Gu Q., Sze K.H., Chu I.K., Kao R.Y.T., Lee K.C., Lam C.W., Yang D., Tai S.S., Ke Y., Chan E., Chan W.M., Dai J., Leung A.S.P., Leung S.Y. and Yuen K.Y., A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis , Journal of Biological Chemistry. 2017, 292: 19503-19520.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Li LL

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Researcher : Lin X

Project Title:	IMMUNOLOGY 2015™ AAI Annual Meeting; A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome
Investigator(s):	Lin X
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

List of Research Outputs

Fu W., Liu X., Lin X., Feng H., Sun L., Li S., Chen H., Tang H., Lu L., Jin W. and Dong C., Deficiency in T follicular regulatory cells promotes autoimmunity, The Journal of Experimental Medicine. 2018, 215: 815-825.

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Rui K., Lin X., Tian J., Wang X., Sun L., Hong X., Liu D., Wang S. and Lu L., Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy, Cellular & Molecular Immunology. 2018, 15: 82-84.

XIAO F., Lin X., Tian J., Wang X., CHEN Q., Rui K., Ma J., Wang S., Wang Q., Wang X., Liu D., Sun L. and Lu L., Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome, Cellular & Molecular Immunology. 2017.

Researcher : Liu J

List of Research Outputs

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : Lo CLR

Project Title:	Study of the clinical relevance and functional role of Stanniocalcin 1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016
Completion Date:	02/2019

Project Title:	Epigenetic regulation of Cripto-1 expression in hepatocellular carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	Clinical relevance and functional characterization of Cripto-1 in conferring stemness properties of hepatocellular carcinoma
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2016

Project Title:	Delineation and validation of downstream targets of GATA6 in conferring stemness features of liver cancer
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	The role of STC1 in liver fibrosis - a pilot study
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2018

Project Title:	International Society for Stem Cell Research (ISSCR) Annual Meeting 2018; DOWNREGULATION OF GATA6 DRIVES THE PHENOTYPIC REPROGRAMMING IN HUMAN HEPATOCELLULAR CARCINOMA
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017.

CHENG Y.L.B., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Lin C.H., Lo C.L.R., Ma S.K.Y., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Research. 2018, 78(9): 2332-2242.

Chan K.S. and Lo C.L.R., Deregulation Of Frizzled Receptors In Hepatocellular Carcinoma, International Journal Of Molecular Sciences. MDPI, 2018, 19: 313.

Cheng B.Y., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Ma S.T., Lin C., Lo C.L.R., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Res . 2018.

Chiu W.H.K., Cheung T.T., Lo C.L.R., Yuan H. and Chan L., Diagnostic performance of dual-tracer positron emission tomography-CT with 18F-fluorodeoxyglucose and 11C-acetate versus modified response evaluation criteria in solid tumors in the assessment of residual viable tumours in HCC that received loco-regional therapy, Insights into Imaging. 2018, 9: 651-704.

Lo C.L.R., Leung C.O., Chan K.K., Ho D.W.H., Wong C.M., Lee T.K. and Ng I.O.L., Cripto-1 activates Wnt/-catenin signaling via binding with Frizzled-7 and Disheveled 3 to regulate stemness phenotypes in hepatocellular carcinoma, Cell Death & Differentiation 2018.

Lo C.L.R., CHAN K.S., Chok K.S.H. and Ng I.O.L., Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre, Journal of Clinical Pathology. 2017, Epub ahead of print.

Lo C.L.R., Leung O.N., Chok K.S.H. and Ng I.O.L., Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study, Diagnostic Pathology. 2017, 12(1): 56.

Lo C.L.R., 2018.

Lo C.L.R., 2017.

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Researcher : Lo J

List of Research Outputs

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Researcher : Loong F

List of Research Outputs

Chan K.H., Lee R., Lau G.K.K. and Loong F., Orbital Ectopic Lymphoid Follicles with Germinal Centers in Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorders, Frontiers in Immunology. 2018, 8: 1947.

Chan S.Y.T., Li J., Loong F., Khong P.L., Tse E.W.C. and Kwong Y.L., PD1 blockade with low-dose nivolumab in NK/T cell lymphoma failing l-asparaginase: efficacy and safety, Annals of Hematology. 2017.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Leptin regulates plasma cell generation and survival in autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Outstanding Researcher Award 2012-13
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2014

Project Title:	The role of B1 cells in the development of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Role of B cells in the pulmonary anti-viral immune response
Investigator(s):	Lu L, Ma K
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Major Research Project
Start Date:	01/2015

Project Title:	The Role of B cells in the development of experimental Sjogren's syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Studies on the Pathogenesis and Treatment of Sjören’s Syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Croucher Foundation - Research Grants
Start Date:	01/2016

Project Title:	The Role of interleukin-17 in the pathogenesis of experimental Sjögren's syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	The role of B cells in the pathogenesis of lung fibrosis during influenza infection
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017
Completion Date:	02/2018

Project Title:	8th European Immunology Conference; A critical role of leptin in promoting B cell response during the development of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

Project Title:	The role of B-1 cells in modulating pulmonary T cell response against influenza infection
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	11th International Congress on Autoimmunity ; T FOLLICULAR HELPER CELLS PTOMOTE SALIVARY DYSFUNCTION VIA ELICITING AUTOREACTIVE B CELL RESPONSE IN EXPERIMENTAL SJOGREN’S SYNDROME
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

List of Research Outputs

Ding L., Wang X., Hong X., Lu L. and Liu D., IL-36 cytokines in autoimmunity and inflammatory disease, Oncotarget. 2018, 9.

Fu W., Liu X., Lin X., Feng H., Sun L., Li S., Chen H., Tang H., Lu L., Jin W. and Dong C., Deficiency in T follicular regulatory cells promotes autoimmunity, The Journal of Experimental Medicine. 2018, 215: 815-825.

Hu F., Zhang W., Shi L., Liu X., Jia Y., Xu L., Zhu H., Li Y., Xu D., Lu L., Qiu X., Liu W., Qiao J., Wang Y. and Li Z., Impaired CD27+IgD+ B Cells With Altered Gene Signature in Rheumatoid Arthritis, Frontiers in Immunology. 2018, 9.

Kwok J.S.Y., GUO M., Yang W., Ip P., Chan G.C.F., Ho J., Lee C.K., Middleton D. and Lu L., Estimation of optimal donor number in Bone Marrow Donor Registry: Hong Kong’s experience, Human Immunology. Elsevier Inc, 2017.

MA H., Liu C., Shi B., Zhang Z., Feng R., Guo M., Lu L., Shi S., Gao X., Chen W. and Sun L., Mesenchymal Stem Cells Control Complement C5 Activation by Factor H in Lupus Nephritis, EBioMedicine. 2018, 32: 21-30.

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Rui K., Lin X., Tian J., Wang X., Sun L., Hong X., Liu D., Wang S. and Lu L., Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy, Cellular & Molecular Immunology. 2018, 15: 82-84.

Wang D., Wang S., Huang S., Zhang Z., Yuan X., Feng X., Lu L. and Sun L., Serum IFN-γ Predicts the Therapeutic Effect of Mesenchymal Stem Cells Transplantation in Systemic Lupus Erythematosus Patients, STEM CELLS Translational Medicine. 2017, 6: 1777-1785.

XIAO F., Lin X., Tian J., Wang X., CHEN Q., Rui K., Ma J., Wang S., Wang Q., Wang X., Liu D., Sun L. and Lu L., Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome, Cellular & Molecular Immunology. 2017.

Researcher : MA KF

List of Research Outputs

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Researcher : MA PY

List of Research Outputs

MA P.Y. and Yam J.W.P., The clinical relevance functional role of ACADM in Hepatocellular Carcinoma, 25th Biennial Congress of the European Association for Cancer Research. 2018.

Researcher : MOK KC

List of Research Outputs

Tsoi H., MOK K.C., Man P.S., Chou K.M. and Khoo U.S., KPNA1 mediates the nuclear import of BQ323636.1 and confer tamoxifen resistance in breast cancer cells. , 109th Annual Meeting for the American Association for Cancer Research, Chicago, Illinois. 2018.

Researcher : Ma ESK

List of Research Outputs

Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017.

Researcher : Ma K

List of Research Outputs

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Researcher : Ma ST

List of Research Outputs

Cheng B.Y., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Ma S.T., Lin C., Lo C.L.R., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Res . 2018.

Gong C., Man P.S., Tsoi H., Lee T.K.W., Lee P., Ma S.T., Wong L.S., Luk M.Y., Rakha E.A., Green A.R., Ellis I.O., Lam E.W.F., Cheung K.L. and Khoo U.S., BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer, Clinical Cancer Research. 2018.

Researcher : Mak CM

List of Research Outputs

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Researcher : Man HY

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Man PS

List of Research Outputs

Gong C., Man P.S., Tsoi H., Lee T.K.W., Lee P., Ma S.T., Wong L.S., Luk M.Y., Rakha E.A., Green A.R., Ellis I.O., Lam E.W.F., Cheung K.L. and Khoo U.S., BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer, Clinical Cancer Research. 2018.

Leung M.H., Tsoi H., Man P.S., Lam E.W.F. and Khoo U.S., The role of BQ323636.1, a novel splice variant of NCOR2, in modulation of oxidative stress in breast cancer, AACR Advances in Breast Cancer Research Special Conference, Hollywood, California. 2017.

Tsoi H., MOK K.C., Man P.S., Chou K.M. and Khoo U.S., KPNA1 mediates the nuclear import of BQ323636.1 and confer tamoxifen resistance in breast cancer cells. , 109th Annual Meeting for the American Association for Cancer Research, Chicago, Illinois. 2018.

Researcher : Mao X

Project Title:	Inhibition of reactive oxygen species upregulation of caveolin-1 by propofol contributes to the suppression of hepatocellular growth and aggressiveness
Investigator(s):	Mao X, Yam JWP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

Project Title:	Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference ; The functional role of exosomal Nidogen-1 in facilitating liver cancer metastasis
Investigator(s):	Mao X
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

List of Research Outputs

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Tey S.K., Mao X. and Yam J.W.P., Role of Exosomes in Liver Cancer Metastasis, The International Society for Extracellular Vesicles (ISEV) Annual Meeting 2018.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL, Tung KK
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2011

Project Title:	Cancer Biology
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Croucher Summer Courses
Start Date:	08/2013

Project Title:	Delineation of the role of RPS6KA3, which encodes p90 ribosomal S6 kinase 2 (RPS6KA3), and their natural mutants in liver cancer
Investigator(s):	Ng IOL, Chan LK, Chiu YT, Ho DWH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015
Completion Date:	10/2017

Project Title:	Characterization of functions of RhoE/ROCK pathway in regulating chemoresistance of liver cancer
Investigator(s):	Ng IOL, Ma W
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015
Completion Date:	03/2018

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL, Wong CCL, Cui C
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Characterization of anti-CCL28 as a novel therapy to overcome sorafenib resistance in HCC
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Role of RalA and RalGAP in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Understanding Cancer Stemness in Liver Cancer – From Regulation to Translational Applications
Investigator(s):	Ng IOL, Guan X, Sham PC, Wong CCL, Ching YP, Jin D, Ma SKY, Mak TW, Wong CM, Poon RTP, Yau TCC, Cheung TT
Department:	Pathology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2017

Project Title:	The role of RalA GTPase and its regulator RalGAP in liver cancer
Investigator(s):	Ng IOL, Chan LK, Ho DWH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment
Investigator(s):	Ng IOL, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	The role of hypoxia-induced ephrinA3-ephrin receptor signaling in liver cancer
Investigator(s):	Ng IOL, Chiu YT
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Laennec Society Annual Meeting 2018; Molecular pathogenesis of hepatocellular carcinoma
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

Project Title:	Genetic changes, expression and molecular mechanisms of TSC complex in liver cancer
Investigator(s):	Ng IOL, Chan LK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Brunt E., Aishima S., Clavien P.A., Fowler K., Goodman Z., Kondo F., Miksad R., Nakano M., Nakanuma Y., Ng I.O.L., Paradis V., Park Y.N., Quaglia A., Roncalli M., Sakamoto M., Saxena R., Sempoux C., Sirlin C., Stueck A. and Thung S., Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation, Hepatology. 2018.

Burt A.D., Alves V., Bedossa P., Clouston A.D., Guido M., Hubscher S.G., Kakar S., Ng I.O.L., Park Y.N., Reeves H.L., Wyatt J., Yeh M.M. and Ellis D.W., Dataset for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: Recommendations from the international collaboration on cancer reporting (ICCR). , Histopathology. 2018.

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017.

CHENG Y.L.B., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Lin C.H., Lo C.L.R., Ma S.K.Y., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Research. 2018, 78(9): 2332-2242.

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Cheng B.Y., Lau E.Y., Leung D.H., Ho N.P., Cheng L.K., Ma S.T., Lin C., Lo C.L.R., Ng I.O.L. and Lee T.K., IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma, Cancer Res . 2018.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Ho D.W.H. and Ng I.O.L., TCGA whole-exome sequencing data reveals mutational parameters in distinguishing potential cancer drivers, Human Genome Meeting 2018.

Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E., Sharma R., Hodgson L. and Cheung M.C.H., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, In: J Ann Le Good, Nature Communications. 2017, 8: 1185.

Liu A.J., Rao Y.X., Cheung M.P.L., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheah K.S.E. and Hodgson L., Faculty Outstanding Research Output Award , Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017, 1185: 1185.

Liu J., Rao Y., Cheung M., Hui M.N., Wu M.H., Chan L.K., Ng I.O.L., Niu B., Cheak K., Sharma R., Hodgson L. and Cheung M., Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration, Nat Commun . 2017.

Liu X., Lo C.M., Cheng Q., Ng K.T.P., Shao Y., LI C., Chung S.K., Ng I.O.L., Yu J. and Man K., Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling., Theranostics. 2017, 7: 4879-4893.

Lo C.L.R., Leung C.O., Chan K.K., Ho D.W.H., Wong C.M., Lee T.K. and Ng I.O.L., Cripto-1 activates Wnt/-catenin signaling via binding with Frizzled-7 and Disheveled 3 to regulate stemness phenotypes in hepatocellular carcinoma, Cell Death & Differentiation 2018.

Lo C.L.R., CHAN K.S., Chok K.S.H. and Ng I.O.L., Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre, Journal of Clinical Pathology. 2017, Epub ahead of print.

Lo C.L.R., Leung O.N., Chok K.S.H. and Ng I.O.L., Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study, Diagnostic Pathology. 2017, 12(1): 56.

Lo R.C., Chan K.K., Leung C.O. and Ng I.O.L., Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts - an immunohistochemical study, Clin Transplant . 2018.

MA K.F., Lau E.Y., Leung D.H., Lo J., Ho N.P., CHENG Y.L.B., Ma S.K.Y., Lin C., Copland J.A., Ding J., Lo C.L.R., Ng I.O.L. and Lee T.K., Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation, Journal of Hepatology. 2017, 67(5): 979-990.

Ng I.O.L., Gastroenterology (International Consultant), 2018.

Ng I.O.L., Hepatology. 2018.

Ng I.O.L., Liver cancer - genetics, cell signalling, and cancer stemness and their translational implications, Duke-NUS Medical School, Singapore. 2017.

Ng I.O.L., Liver cancer stem cells - Characterization and a target for prevention and treatment of HCC, Asian Pacific Association for the Study of Liver meeting, New Delhi, India. 2018.

Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma – Update on the odyssey, Laennec Liver Pathology Society Meeting, Halifax, Canada. 2018.

Ng I.O.L., Molecular stratification of HCC - a step closer to precision medicine, Asian Pacific Association for the Study of Liver meeting, New Delhi, India. 2018.

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Tong A.C., Ng I.O.L. and Lo M.C., A case of immunoglobulin G4-related sclerosing disease involving the mandible, HK Med J . 2017.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Wong C.M., Tsang F.H. and Ng I.O.L., Regulatory RNAs in hepatocellular carcinoma: molecular functions and pathological implications, Nat Rev Gastroenterol Hepatol . 2018, 15: 1371.

YANG X., Cheung M.P.L., Wong C.M., Ng I.O.L., Lung H.L. and Cheung M.C.H., Elucidating the role of DLC1, a RhoGTPase-activating protein, in metastatic melanoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Ngan HYS

Project Title:	High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer
Investigator(s):	Ngan HYS, Wong LCR
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1994

Project Title:	Investigation on the oncogenic roles of HPV-E6 and mCRPs in cervical cancer cells
Investigator(s):	Ngan HYS, Leung THY, Siu KY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Functional characterization of the roles of NR4A2 in cervical cancer cells
Investigator(s):	Ngan HYS, Leung THY, Siu KY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Investigation on the association of CD109 and STAT3 activity in regulating cervical cancer cell metastasis
Investigator(s):	Ngan HYS, Leung THY, Siu KY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2018

List of Research Outputs

Chan K.K., Wong E.S.Y., Wong G.W., Ngan H.Y.S. and Cheung A.N.Y., Identification of nonsynonymous TP53 mutations in hydatidiform moles, Identification of nonsynonymous TP53 mutations in hydatidiform moles. 2018, 20-23.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Sialoglyco 2014; Glycomic Characterization of Respiratory Tract Tissues of Ferrets Shows Expression of Different Sialylatyed Glycans to Humans: Implications for the Use of Ferrets in Influenza Virus Infection Studies.
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014

Project Title:	Modulation of MERS-CoV infection of the human ex vivo respiratory tract by the use of interferon, cyclophilin inhibitors and blocking antibody therapy
Investigator(s):	Nicholls JM, Chan WY
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	The viral genetic determinants of influenza H5N1 virus in causing acute lung injury - an in vitro study
Investigator(s):	Nicholls JM, Chan MCW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2015

Project Title:	ESWI 2017 Influenza Conference; The Influence On Influenza Replication by the Sda Epitope
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017

List of Research Outputs

Chan R.W.Y., Chan L.Y., Mok K.P., Lai J.C.C., Tao K.P., Obadan A., Chan M.C.W., Perez D.R., Peiris J.S.M. and Nicholls J.M., Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release, Scientific Reports. 2017, 7(1): 6208.

Chin W.H., Leong K.C., Nicholls J.M. and Poon L.M.L., Characterization of influenza A viruses with polymorphism in PB2 residues 701 and 702, Scientific Reports. 2017, 7(1): 11361.

Chu K.W., Hui P.Y., Perera R.A.P.M., Miguel E., Niemeyer D., Zhao J., Channappanavar R., Dudas G., Oladipo J.O., Traoré A., Fassi-Fihri O., Ali A., Demissié G.F., Muth D., Chan M.C.W., Nicholls J.M., Meyerholz D.K., Kuranga S.A., Mamo G., ZHOU Z., SO T.Y., Hemida M.G., Webby R.J., Roger F., Rambaut A., Poon L.M.L., Perlman S., Drosten C., Chevalier V. and Peiris J.S.M., MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity, Proceedings of the National Academy of Sciences. 2018, 115(12): 3144-9.

Researcher : Poon DWT

List of Research Outputs

Mak C.M., Chen S.P.L., Mok N.S., Siu W.K., Lee H.H.C., Ching D.C.K., Tsui P.T., Fong N.C., Yuen Y.P., Poon D.W.T., Law C.Y., Chong Y.K., Chan Y.W., Yung T.C., Fan K.Y. and Lam C.W., Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience, Hong Kong Medical Journal. 2018.

Researcher : Shek TWH

List of Research Outputs

Wong K.P., Liu G.Y.L., Chan M.P., Shek T.W.H. and Lang H.H.B., Subcategorisation: improved stratification of thyroid nodule with cytological results of atypia of undetermined significance, The 2nd Congress of Asia-Pacific Society of Thyroid Surgery (APTS 2017), Okinawa, Japan, 1-3 November 2017.

Researcher : Sin CF

List of Research Outputs

Kho C.S., Wong H.N., Sin C.F., Leung Y.Y. and Kwong Y.L., Leonine facies due to Sezary syndrome: complete clinical, radiologic, and molecular remission with alemtuzumab, Annals of Hematology. 2017, 96: 2121-2123.

Researcher : Siu HC

List of Research Outputs

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

Researcher : So JCC

List of Research Outputs

Lam S.S.Y., Ho E.S.K., He B.A., Wong W.W., Cher C.Y., Ng N.K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So E.C.W., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong. 2017.

Singh G.H.H., Ip H.W., Yim R.L.H., Tang T.W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-Generation Sequencing with a 54-Gene Panel Identifies Unique Mutational Profile and Prognostic Markers in Chinese Patients with Myelofibrosis, 59th American Society of Haematology (ASH) Annual Meeting and Exposition in Atlanta, GA,. Blood, 2017, Supplement 8 December 2017.

Researcher : Srivastava G

Project Title:	Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

List of Research Outputs

Reddy A., Zhang J., Davis N.S., Moffitt A.B., Love C.L., Waldrop A., Leppa S., Pasanen A., Meriranta L., Karjalainen-Lindsberg M.L., Nørgaard P., Pedersen M., Gang A.O., Høgdall E., Heavican T.B., Lone W., iqbal J., Qin Q., Li G., Kim S.Y., Healy J., Richards K.L., Fedoriw Y., Bernal-Mizrachi L., Koff J.L., Staton A.D., Flowers C.R., Paltiel O., Goldschmidt N., Calaminici M., Clear A., Gribben J., Nguyen E., Czader M.B., Ondrejka S.L., Collie A., Hsi E.D., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Choi W.L., Evens A.M., Pilichowska M., Sengar M., Reddy N., Li S., Chadburn A., Gordon L.I., Jaffe E.S., Levy S., Rempel R., Tzeng T., Happ L.E., Dave T., Rajagopalan D., Datta J., dunson D.B. and Dave S.S., Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma, Cell. 2017, 171: 481-494.e15.

Researcher : Sze MF

Project Title:	The characterizations of Ubiquitin-Conjugating Enzyme E2O (UBE2O) in mitotic checkpoint control via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Tam S

List of Research Outputs

Li R.H.W., Lam K.S.L., Tam S., Wong E.W.K., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction of incident metabolic syndrome and dysglycaemia by adiposity and insulin resistance indices in Chinese women with polycystic ovary syndrome: a 4-year longitudinal study, 100th Annual Meeting & Expo of the Endocrine Society. 2018.

Li R.H.W., Lam K.S.L., Tam S., Wong E.W.K., Lee V.C.Y., Cheung P.T., Ho P.C. and Ng E.H.Y., Prediction of metabolically unhealthy phenotype by the visceral adiposity index, lipid accumulation product and triglyceride-glucose index in Chinese women with polycystic ovary syndrome, 33rd Annual Meeting, European Society of Human Reproduction and Embryology. 2017.

Researcher : Tey SK

List of Research Outputs

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Tey S.K., Mao X. and Yam J.W.P., Role of Exosomes in Liver Cancer Metastasis, The International Society for Extracellular Vesicles (ISEV) Annual Meeting 2018.

Researcher : Tin PC

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Lam K.Y.I., Xiao Z., Tin P.C., Huang F. and Wong M.P., NFATc2 in non-small cell lung cancer mediates inhibition of peripheral blood mononuclear cell proliferation, 110th Annual Meeting of the American Association for Cancer Research. 2017.

WANG S., Xiao Z., Tin P.C., GAO X. and Wong M.P., Stress response through theCaMK2A/NRF2/GSTP1 axis strengthens cancer cell resilience and mediates stemness phenotype through ROS attenuation, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : Tsang FH

Project Title:	Characterization of a novel tumor suppressive long non-coding RNA linc-ALDH1A2-1 in hepatocellular carcinoma
Investigator(s):	Tsang FH, Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2017

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Wong C.M., Tsang F.H. and Ng I.O.L., Regulatory RNAs in hepatocellular carcinoma: molecular functions and pathological implications, Nat Rev Gastroenterol Hepatol . 2018, 15: 1371.

Researcher : Tsang LH

List of Research Outputs

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Researcher : Tse EWC

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Provision of obinutuzumab (anti-CD20 monoclonal antibody) to elderly and/or unfit patients with chronic lymphocytic leukaemia
Investigator(s):	Tse EWC, Kwong YL, Chan SYT
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2017
Completion Date:	01/2018

Project Title:	PTCL Study - PD-1 blockade with pembrolizumab in relapsed/refractory mature T-cell and NK-cell lymphomas
Investigator(s):	Tse EWC, Kwong YL, Singh GHH
Department:	Medicine
Source(s) of Funding:	Merck, Sharp and Dohme (Asia) Ltd. - General Award
Start Date:	06/2017

List of Research Outputs

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Researcher : Tse PW

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Researcher : Tsoi H

List of Research Outputs

Gong C., Man P.S., Tsoi H., Lee T.K.W., Lee P., Ma S.T., Wong L.S., Luk M.Y., Rakha E.A., Green A.R., Ellis I.O., Lam E.W.F., Cheung K.L. and Khoo U.S., BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer, Clinical Cancer Research. 2018.

Leung M.H., Tsoi H., Man P.S., Lam E.W.F. and Khoo U.S., The role of BQ323636.1, a novel splice variant of NCOR2, in modulation of oxidative stress in breast cancer, AACR Advances in Breast Cancer Research Special Conference, Hollywood, California. 2017.

Tsoi H., MOK K.C., Man P.S., Chou K.M. and Khoo U.S., KPNA1 mediates the nuclear import of BQ323636.1 and confer tamoxifen resistance in breast cancer cells. , 109th Annual Meeting for the American Association for Cancer Research, Chicago, Illinois. 2018.

Researcher : Tsui EY

List of Research Outputs

Wong G.W., Ho M.W., Tsun O.K.L., Ng A.K., Tsui E.Y., Chow J.N., Ip P.C.P. and Cheung A.N.Y., An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity, Cytopathology. 2018, 29: 267-274.

Researcher : Tsui WY

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Tsui YM

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Tsun OKL

List of Research Outputs

Wong G.W., Ho M.W., Tsun O.K.L., Ng A.K., Tsui E.Y., Chow J.N., Ip P.C.P. and Cheung A.N.Y., An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity, Cytopathology. 2018, 29: 267-274.

Researcher : WANG S

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

WANG S., Xiao Z., Tin P.C., GAO X. and Wong M.P., Stress response through theCaMK2A/NRF2/GSTP1 axis strengthens cancer cell resilience and mediates stemness phenotype through ROS attenuation, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : WEI L

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Researcher : Wang X

Project Title:	IL-17-producing γδ T cell response and its regulation during influenza virus infection
Investigator(s):	Wang X, Lu L
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2018

List of Research Outputs

Ding L., Wang X., Hong X., Lu L. and Liu D., IL-36 cytokines in autoimmunity and inflammatory disease, Oncotarget. 2018, 9.

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Rui K., Lin X., Tian J., Wang X., Sun L., Hong X., Liu D., Wang S. and Lu L., Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy, Cellular & Molecular Immunology. 2018, 15: 82-84.

XIAO F., Lin X., Tian J., Wang X., CHEN Q., Rui K., Ma J., Wang S., Wang Q., Wang X., Liu D., Sun L. and Lu L., Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome, Cellular & Molecular Immunology. 2017.

Researcher : Wei L

List of Research Outputs

Researcher : Wong CCL

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	01/2019

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

Project Title:	Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	The molecular regulations, roles, and clinical implications of hypoxia-induced porcupine in hepatocellular carcinoma
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Outstanding Young Researcher Award 2016-17
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2018

Project Title:	Translational Immunometabolism; Repurposing auranofin, a thioredoxin reductase 1 (TXNRD1) inhibitor and an anti-rheumatic agent, for hepatocellular carcinoma (HCC) treatment
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018

List of Research Outputs

CHAN K.S., Leung O.N., Wong C.C.L., Ho D.W.H., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway, Cancer Letters. 2017, 403: 330-338.

CHAN K.S., Leung O.N., Wong C.C.L., Chok K.S.H., Lai C.L., Ng I.O.L. and Lo C.L.R., Stanniocalcin 1 Promotes Metastasis Of Hepatocellular Carcinoma Through Activation Of Jnk Signaling, International Liver Cancer Association Annual Conference 2017.

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Wong C.C.L., Hypoxia inducible factor-1 (HIF-1)/ENTPD2 maintained hepatocellular carcinoma an immune-suppressive microenvironment, International Liver Cancer Association (ILCA) Annual Meeting, Seoul, Korea. 2017.

Wong C.C.L., The Crossroad of Metabolism and Immunity in Liver Cancer. City University of Hong Kong. Department of Biomedical Science seminar, 2017.

Wong C.C.L., The Pentose Phosphate Pathway and Folate Cycle Protect Liver Cancer Cells from Oxidative stress. EMBO Workshop: Thiol Oxidation in Toxicity and Signaling. Spain, 2017.

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Wong CL

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	01/2019

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

Project Title:	Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	The molecular regulations, roles, and clinical implications of hypoxia-induced porcupine in hepatocellular carcinoma
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Outstanding Young Researcher Award 2016-17
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2018

Project Title:	Translational Immunometabolism; Repurposing auranofin, a thioredoxin reductase 1 (TXNRD1) inhibitor and an anti-rheumatic agent, for hepatocellular carcinoma (HCC) treatment
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018

List of Research Outputs

Researcher : Wong CM

Project Title:	Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Clinicopathological significance and functional roles of G9a up-regulation in Hepatocellular Carcinoma
Investigator(s):	Wong CM, Wong CCL, Tsang FH
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	The roles of RNA N6-Adensoine methylation in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL, Tsang FH
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016
Completion Date:	01/2018

Project Title:	Deregulation and somatic mutations of histone methyltransferase ASH1L in liver cancer.
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Pathological implications and functional characterizations of novel long non-coding RNA linc-CHD1L-1 in hepatocellular carcinoma
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	The roles of bromodomain containing proteins in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

Project Title:	Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	03/2017

Project Title:	Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Chen M., Wei L., Law D.C., Tsang F.H., Shen J., Cheng C.L., Tsang L.H., Ho D.W.H., Chiu D.K., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., RNA N6-adenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent SOCS2 silencing, Hepatology. 2018, 67: 2254.

Chiu D.K., Tse A.P., Xu I.M., Lai R.K., Koh H.Y., Tsang F.H., Wei L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell (MDSC) accumulation through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in cancer, Nat Commun . 2017.

Lo C.L.R., Leung C.O., Chan K.K., Ho D.W.H., Wong C.M., Lee T.K. and Ng I.O.L., Cripto-1 activates Wnt/-catenin signaling via binding with Frizzled-7 and Disheveled 3 to regulate stemness phenotypes in hepatocellular carcinoma, Cell Death & Differentiation 2018.

Tse P.W., Sze K.M., Shea Q.T., Chiu E.Y., Tsang F.H., Chiu D.K., Zhang M.S., Lee D., Xu I.M., Chan C.Y., Koh H.Y., Wong C.M., Zheng Y.P., Ng I.O.L. and Wong C.C.L., Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer, Oncogenesis. 2018, 7: 44.

Wei L., Chiu K.C., Tsang F.H., Law C.T., Cheng L.H.C., Au L.K.S., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3, Journal of Hepatology. 2017, 67: 758-769.

Wong C.M., Delineating epigenetic alterations in liver cancer, Croucher Summer Course in Cancer Biology. Hong Kong, 2017.

Wong C.M., Tsang F.H. and Ng I.O.L., Regulatory RNAs in hepatocellular carcinoma: molecular functions and pathological implications, Nat Rev Gastroenterol Hepatol . 2018, 15: 1371.

YANG X., Cheung M.P.L., Wong C.M., Ng I.O.L., Lung H.L. and Cheung M.C.H., Elucidating the role of DLC1, a RhoGTPase-activating protein, in metastatic melanoma, 22nd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2017.

Researcher : Wong ESY

List of Research Outputs

Chan K.K., Wong E.S.Y., Wong G.W., Ngan H.Y.S. and Cheung A.N.Y., Identification of nonsynonymous TP53 mutations in hydatidiform moles, Identification of nonsynonymous TP53 mutations in hydatidiform moles. 2018, 20-23.

Chan K.K., Wong G.W., Wong E.S.Y., Chan K.K.L., Ip P.C.P., Tse K.Y. and Cheung A.N.Y., Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma, International Journal of Cancer. 2018.

Researcher : Wong GW

Project Title:	Identification of HNF-1β direct targets in ovarian clear cell carcinoma
Investigator(s):	Wong GW, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Chan K.K., Wong E.S.Y., Wong G.W., Ngan H.Y.S. and Cheung A.N.Y., Identification of nonsynonymous TP53 mutations in hydatidiform moles, Identification of nonsynonymous TP53 mutations in hydatidiform moles. 2018, 20-23.

Chan K.K., Wong G.W., Wong E.S.Y., Chan K.K.L., Ip P.C.P., Tse K.Y. and Cheung A.N.Y., Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma, International Journal of Cancer. 2018.

Wong G.W., Ho M.W., Tsun O.K.L., Ng A.K., Tsui E.Y., Chow J.N., Ip P.C.P. and Cheung A.N.Y., An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity, Cytopathology. 2018, 29: 267-274.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP, Xiao Z
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Harnessing tyrosine kinase inhibitor resistance of EGFR-mutated lung adenocarcinomas through candidate resistant genes screening
Investigator(s):	Wong MP, Ho JCM, Xiao Z, So JCC, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

List of Research Outputs

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP, Xiao Z
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Harnessing tyrosine kinase inhibitor resistance of EGFR-mutated lung adenocarcinomas through candidate resistant genes screening
Investigator(s):	Wong MP, Ho JCM, Xiao Z, So JCC, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Lam K.Y.I., Xiao Z., Tin P.C., Huang F. and Wong M.P., NFATc2 in non-small cell lung cancer mediates inhibition of peripheral blood mononuclear cell proliferation, 110th Annual Meeting of the American Association for Cancer Research. 2017.

WANG S., Xiao Z., Tin P.C., GAO X. and Wong M.P., Stress response through theCaMK2A/NRF2/GSTP1 axis strengthens cancer cell resilience and mediates stemness phenotype through ROS attenuation, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : Wong WC

List of Research Outputs

Ip P.C.P., YU Y., Cheung C.L., Cheuk W., Cheung E., Wong W.C., Lee V., Chan W.K. and Tse K.Y., Female Genital melanomas: A clinicopathologic and PD-L1 expression study, The United States and Canadian Academy of Pathology 107th Annual Meeting . 2018.

Researcher : XIAO F

List of Research Outputs

XIAO F., Lin X., Tian J., Wang X., CHEN Q., Rui K., Ma J., Wang S., Wang Q., Wang X., Liu D., Sun L. and Lu L., Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome, Cellular & Molecular Immunology. 2017.

Researcher : XU M

List of Research Outputs

CHIU K.C., Tse P.W., XU M., Cui D., LAI K.H., Li L.L., Koh H.Y., Tsang F.H., WEI L., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nature Communications. 2017, 8: 517.

Researcher : Xiao Z

Project Title:	American Association for Cancer Research Annual Meeting 2018 2月5日; P38α suppresses tumor initiating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer
Investigator(s):	Xiao Z
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Lam K.Y.I., Xiao Z., Tin P.C., Huang F. and Wong M.P., NFATc2 in non-small cell lung cancer mediates inhibition of peripheral blood mononuclear cell proliferation, 110th Annual Meeting of the American Association for Cancer Research. 2017.

WANG S., Xiao Z., Tin P.C., GAO X. and Wong M.P., Stress response through theCaMK2A/NRF2/GSTP1 axis strengthens cancer cell resilience and mediates stemness phenotype through ROS attenuation, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Xiao Z., Liu J., WANG S., GAO X., Tin P.C. and Wong M.P., P38α suppresses tumor iniating cell phenotypes through inhibition of NFATc4 in non-small cell lung cancer, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : Xu F

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

Researcher : YANG X

List of Research Outputs

Ma K., Li J., Wang X., Lin X., DU W., YANG X., Mou F., Fang Y., Zhao Y., Hong X., Chan K.W., Zhang X., Liu D., Sun L. and Lu L., TLR4 + CXCR4 + plasma cells drive nephritis development in systemic lupus erythematosus , Annals of the Rheumatic Diseases. 2018, annrheumdis-2018-213615.

Researcher : YU Y

List of Research Outputs

Ip P.C.P., YU Y., Cheung C.L., Cheuk W., Cheung E., Wong W.C., Lee V., Chan W.K. and Tse K.Y., Female Genital melanomas: A clinicopathologic and PD-L1 expression study, The United States and Canadian Academy of Pathology 107th Annual Meeting . 2018.

Researcher : YUE SK

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : Yam JWP

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	Functional role and clinical significance of galectin-1 in liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Functional role of hypoxia-induced caveolin-1 in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	Functional role of caveolin-1-mediated S100P in liver cancer metastasis under hypoxic stress
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Functional role of exosomes in liver cancer metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	Exosomes released from nuclear Met expressing cells promote liver cancer metastasis and formation of lung premetastatic niche
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Application of S100P antibody as a strategy for the treatment of liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	The interplay of Rab20 and Sec23A in the biological activities of exosomes in liver cancer
Investigator(s):	Yam JWP, Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Application of antibody specifically target cancer-bound CFH as a therapeutic strategy for liver cancer
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	Downregulation of medium chain acyl-CoA dehydrogenase in liver cancer: Functional outcome and clinical relevance
Investigator(s):	Yam JWP, Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

GAO X., XU H., Ho J.C.M., Xu F., Lee V.H.F., Tin P.C., Xiao Z., WANG S., Yam J.W.P. and Wong M.P., EGFR-mutant lung adenocarcinomas mutation profiles reveal ARID1A might be a novel tyrosine kinase resistance pathway, 111th Annual Meeting of the American Association for Cancer Research. 2018.

MA P.Y. and Yam J.W.P., The clinical relevance functional role of ACADM in Hepatocellular Carcinoma, 25th Biennial Congress of the European Association for Cancer Research. 2018.

Tey S.K., Tse E.W.C., Mao X., Ko F.C.F., Wong A.C.C., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Nuclear Met contributes to tumorigenesis and metastasis of hepatocellular carcinoma by activating TAK1/NF-κB pathway, Cancer Lett . 2017.

Tey S.K., Mao X. and Yam J.W.P., Role of Exosomes in Liver Cancer Metastasis, The International Society for Extracellular Vesicles (ISEV) Annual Meeting 2018.

Yam J.W.P., Reviewer, Nanomedicine. 2018.

Yam J.W.P., State Key Laboratory for Liver Research (SKLLR) Symposium , Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in liver cancer. 2017.

Researcher : Yan HHN

Project Title:	Intestinal organoid cultures of early onset colorectal cancers
Investigator(s):	Yan HHN, Leung SY, Law WL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Characterization of gastric intestinal metaplasia and its role in gastric cancer progression
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2016

Project Title:	Use of whole genome sequencing to unveil new mechanisms of germline DNA mismatch repair gene alterations in Lynch Syndrome patients
Investigator(s):	Yan HHN, Leung SY, Siu HC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

List of Research Outputs

CHAN H.L., Zhou L., Ng K.Y., Wong T.L., CHAI S., Lee T.K., Guan X., Ching Y.P., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Huen M.S.Y. and Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer., AACR 2017 Annual Meeting. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Zhou J., LI C., ZHAO G., Chu H., WANG D., Yan H.H.N., Poon K.M., Wen L.R., WONG H.Y.B., ZHAO X., Chiu M.C., YANG D., WANG Y., Au Yeung K.H.R., Chan I.H.Y., Sun S., Chan J.F.W., To K.K.W., Memish Z.A., Corman V.M., Drosten C., Hung F.N.I., Zhou Y., Leung S.Y. and Yuen K.Y., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus, Science Advances. 2017, 3: eaao4966.

Zhou L., Siu H.C., LOONG H.C., Tong M., Wong T.L., Chai S., XIAN Z., Guan X., Wong D.K.H., Man K., Lo C.M., Yan H.H.N., Leung S.Y., Clevers H. and Ma S.K.Y., Establishment Of Human Primary Hepatocellular Carcinoma-derived Organoid Cultures For Disease Modeling And Drug Screening, International Society For Stem Cell Research (ISSCR) 2018 Annal Meeting. 2018.

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

Researcher : Yuen ST

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Leung W.K., Law W.L., Lee J.F.Y., Chan K.W., Tsui W.Y., Chan A.S.Y., Lee C.H., YUE S.K., Man H.Y., Clevers H., Yuen S.T. and Leung S.Y., Faculty Outstanding Research Output Award, "RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. 2017;66(9):1645-1656", Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Researcher : ZHU Y

List of Research Outputs

Xiao Z., Liu J., WANG S., ZHU Y., GAO X., Qin J., Wang J. and Wong M.P., Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma, Elife. 2017.

Researcher : Zhang X

Project Title:	AACR Annual Meeting 2018; Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo
Investigator(s):	Zhang X
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Researcher : Zhao F

Project Title:	Role of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in breast cancer tumorigenesis
Investigator(s):	Zhao F, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Researcher : Zhao L

Project Title:	American Association for Cancer Research (AACR) Annual Meeting 2018; RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness
Investigator(s):	Zhao L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Zhang X., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Chiu Y.T., Lee E., Wong C.C.L., Zhao L., Lee M.F. and Ng I.O.L., Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo, AACR (American Association for Cancer Research) Annual Meeting 2018 . 2018.

Zhao L., Best Oral Presentation Award for "Hong Kong Scholars Annual Symposium 2018", The Society of Hong Kong Scholars. 2018.

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