DEPARTMENT OF PHYSIOLOGY
| Researcher : Ballard HJ |
| Project Title: | Interactions between vasoconstrictor and vasodilator mechanisms in the skeletal muscle vascular response to systemic hypoxia |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
| Start Date: | 07/2003 |
| Abstract: |
| To investigate the roles of the baroreflex, the central chemoreflex and adaptation of the peripheral chemoreflex in the variation of sympathetic outflow to the muscle during hypoxia, and the mechanism by which sympathetic nerve activation stimulates the formation of interstitial vasodilator metabolites; to investigate the roles of A1 and A2 adenosine receptors in the vascular response to sustained hypoxia, and determine whether the receptors are located on endothelium or vascular smooth muscle; to investigate the mechanisms of the interactions between the release and actions of the vasodilator substances in hypoxia; to investigate the properties and control of the specific isoenzyme of cytosolic 5' -nucleotidase isolated from skeletal muscle vascular endothelial cells. |
| Project Title: | Interactions between vasoconstrictor and vasodilator mechanisms in the skeletal muscle vascular response to systemic hypoxia |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2004 |
| Abstract: |
| To investigate the roles of the baroreflex, the central chemoreflex and adaptation of the peripheral chemoreflex in the variation of sympathetic outflow to the muscle during hypoxia, and the mechanism by which sympathetic nerve activation stimulates the formation of interstitial vasodilator metabolites; to investigate the roles of A1 and A2 adenosine receptors in the vascular response to sustained hypoxia, and determine whether the receptors are located on endothelium or vascular smooth muscle; to investigate the mechanisms of the interactions between the release and actions of the vasodilator substances in hypoxia; to investigate the properties and control of the specific isoenzyme of cytosolic 5' -nucleotidase isolated from skeletal muscle vascular endothelial cells. |
| Project Title: | Interactions between vasoconstrictor and vasodilator mechanisms in the skeletal muscle vascular response to systemic hypoxia |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
| Start Date: | 07/2004 |
| Abstract: |
| Refer to hard copy |
| Project Title: | Sources and actions of adenosine in exercise vasodilation of rat red or white muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To determine the venous and interstitial concentrations of adenosine in red and white muscles, and evaluate the contribution of A1 and A2 receptors to the vasodilation using appropriate blockers. |
| List of Research Outputs |
| Liang H.W., Xia Q., Bruce I.C. and Ballard H.J., Role of free radicals in neuroprotection induced by mitochondrial ATP-sensitive potassium channel opener in rat hippocampal slice during ischemia, FASEB Journal. 2004, 18(5): 3625. |
| Mo F.M. and Ballard H.J., Acute systemic hypoxia elevates venous but not interstitial potassium of dog skeletal muscle, American Journal of Physiolog: Heart & Circulation. 2005, 289: H1710-H1718. |
| Tam L.T.L. and Ballard H.J., The influence of acute, chronic or chronic intermittent hypoxia on NO release from the renal circulation, Journal of the Hong Kong College of Cardiology. 2004, 12: 92. |
| Researcher : Borchert GH |
| List of Research Outputs |
| Liu J., Borchert G.H., Kam W.L. and Wong T.M., Preconditioning restores calcium homeostasis by increasing HSP70 synthesis in the rat heart, J Hong Kong College Cardiol. 2004, 12:107. |
| Researcher : Bourreau JP |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To measure the levels of PGI2 by quantifying its stable hydrolysis product, 6-keto PGF1[alpha] by EIA after stimulation with ADM and at various time-points corresponding to the biphasic inotropic effects of ADM, and to mesure the PGI2 levels in our animal model of terminal septic shock; to observe the signal transduction pathway involved in the ventricular effects of ADM with respect to PGI2. |
| List of Research Outputs |
| Chan Y.C., Yao X.Q., Lau C.W., Chan F.L., He G.W., Bourreau J.P. and Huang Y., The relaxant effect of urocortin in rat pulmonary arteries, Regulatory Peptides. 2004, 121: 11-18. |
| Tu J., Shan Q.X., Jin H.F., Bourreau J.P. and Xia Q., Endothelin-1-Mediated Coronary vasoconstriction deteriorates myocardial depression in hearts isolated from lipopolysaccharide-treated rats: interaction with nitric oxide, Clinical and Experimental Pharmacology and Physiology. 2004, 31: 571-574. |
| Researcher : Bruce IC |
| Project Title: | Biomedical writing for postgraduate students whose mother tongue is Chinese: a novel course based on interactive multimedia |
| Investigator(s): | Bruce IC, Poon P.W.F., Chan R.Y.P., Xia Q. |
| Department: | Physiology |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 02/1999 |
| Abstract: |
| Two tasks need to be accomplished. Firstly, how best to teach and learn the art and craft of creating a manuscript suitable for submission to an international journal. Secondly, how to develop a teaching tool that is sensitive to the specific difficulties encountered by individuals whose usual channels of communication are Chinese. The unifying strategy is to create and interactive web site that can be used, in combination with face-to-face teaching, to develop the desired writing skills and attitudes. |
| List of Research Outputs |
| Bruce I.C., Experiences & skills in teaching medical students in English, Proceedings, 2005 Forum on New Era in Medical Education. 2005, 55-69. |
| Gao Q., Xia Q., Cao C., Zhang S.Z. and Bruce I.C., Role of the mitochondrial permeability transition pore in TNF-alpha-induced recovery of ventricular contraction & reduction of infarct size in isolated rat hearts subjected to ischemia/reperfusion, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 3622-3624. |
| Gu H.Y., Chai H., Zhang J.Y., Yao Z.B., Zhou L.H., Wong S.M., Bruce I.C. and Wu W., Survival, regeneration & functional recovery of motoneurons after delayed reimplantation of avulsed spinal nerve root in adult rat, Experimental Neurology. 2005, 192: 89-99. |
| Jiang H.D., Xia Q., Wang X., Song J. and Bruce I.C., Luteolin induces vasorelaxation in rat thoracic aorta via calcium & potassium channels, Pharmazie. 2005, 60: 444-447. |
| Liang H.W., Xia Q., Bruce I.C. and Ballard H.J., Role of free radicals in neuroprotection induced by mitochondrial ATP-sensitive potassium channel opener in rat hippocampal slice during ischemia, FASEB Journal. 2004, 18(5): 3625. |
| Lin R., Zhang Z.W., Xiong Q.X., Cao C., Shu Q., Bruce I.C. and Xia Q., Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest , Annals of Thoracic Surgery. 2004, 78: 970-975. |
| Wu B., Wang Y.M., Xiong W., Zheng L.H., Fu C.L., Bruce I.C., Zhang C. and Zhou Z., Optimization of a multi-channel puffer system for rapid delivery of solutions during patch-clamp experiments, Frontiers in Bioscience. 2005, 10: 761-767. |
| Wu P., Bao J., Xia Q. and Bruce I.C., The use of artificial neural networks in the motor program, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 4611-4613. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Yu Y.Q., Xia Q., Zhang R.B., Shan Q.X. and Bruce I.C., Dorsal column is not involved in the mechanism of the hypotensive effect by stimulating acupuncture on rat hindlimb, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 4741-4743. |
| Zhang S.Z., Xia Q., Cao C., Gao Q. and Bruce I.C., The mitochondrial calcium uniporter participates in ischemia/reperfusion injury & in cardioprotection by ischemic preconditioning, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 3625-3627. |
| Researcher : Cao C |
| List of Research Outputs |
| Cao C., Xia Q., Gao Q., Chen M. and Wong T.M., Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning, J Pharmacol Exp Ther. 2005, 312(2): 644-50. |
| Cao C., Xia Q. and Wong T.M., Cardioprotection of interleukin-2 is mediated via k-opioid receptor, J Pharmacol Exp Ther . 2004, 309(2): 560-567. |
| Gao Q., Xia Q., Cao C., Zhang S.Z. and Bruce I.C., Role of the mitochondrial permeability transition pore in TNF-alpha-induced recovery of ventricular contraction & reduction of infarct size in isolated rat hearts subjected to ischemia/reperfusion, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 3622-3624. |
| Li G., Zou L., Cao C., Jack C.R. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells by the Inhibition of the Opening of the Mitochondrial Permeability Transition Pore, Fourth World Conference of the International CoenzymeQ10 Association. 2005, 134-136. |
| Li G., Zou L., Cao C. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells form Toxicity of Beta Amyloid-42 via Inhibition of Mitochondrial Permeability Transition Pore Opening, Drug Discovery in Neurodegenerative Diseases. 2004, 34. |
| Lin R., Zhang Z.W., Xiong Q.X., Cao C., Shu Q., Bruce I.C. and Xia Q., Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest , Annals of Thoracic Surgery. 2004, 78: 970-975. |
| Wong T.M. and Cao C., Role of calcium activated potassium channel in cardioprotection of preconditioning – mechanisms of action, CAPS News Communication. 2005, 21(12) Suppl,3. |
| Zhang S.Z., Xia Q., Cao C., Gao Q. and Bruce I.C., The mitochondrial calcium uniporter participates in ischemia/reperfusion injury & in cardioprotection by ischemic preconditioning, Proceedings, 26th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2004, 3625-3627. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology. 2005, 102(2): 371-8. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors, Anesthesiology. USA, 2005, 102: 371-378. |
| Researcher : Chan YS |
| Project Title: | Spatial organization of otolith information in the vestibulo-olivary pathway |
| Investigator(s): | Chan YS, Yung KKL |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 12/2001 |
| Abstract: |
| To ascertain that otolith information is topographically represented within the inferior olivary complex; to test if glutamate from the vestibular nucleus is a modulatory agent for otolith-related vestibulo-olivocerebellar circuit. |
| Project Title: | Formation of gravity-related spatial map in postnatal rats |
| Investigator(s): | Chan YS, Yung KKL |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2002 |
| Abstract: |
| A fundamental question in otolith system development is how gravity-related spatial information of the adult pattern emerges. It is hypotheszed in the study that the maturation in coding of specific head orientations may not be in phase with each other, i.e. there is a critical maturation period before which recognition of a specific head orientation cannot operate. The project attempts to use linear acceleration along horizontal and vertical directions, selected to activate specific subset(s) of receptors on the utricular and saccular maculae respectively. |
| Project Title: | Sensitive period for topographic spatial representation in the rat otolith system |
| Investigator(s): | Chan YS, Yung KKL |
| Department: | Physiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 11/2003 |
| Abstract: |
| To determine whether the functional organization of a gravity-related spatial reference in the postnatal inferior olive is perturbed by perinatal blockade of the vestibular nucleus; to determine whether the spatial coding capacity of adult neurons are perturbed well after an early postnatal blockade becomes ineffective; to examine if the pharmacological manipulations applied later in the postnatal period have any effect in the mature brain. |
| Project Title: | Sensitive period for topographic spatial representation in the rat otolith system |
| Investigator(s): | Chan YS, Yung KKL |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2003 |
| Abstract: |
| To determine whether the functional organization of a gravity-related spatial reference in the postnatal inferior olive is perturbed by perinatal blockade of the vestibular nucleus; to determine whether the spatial coding capacity of adult neurons are perturbed well after an early postnatal blockade becomes ineffective; to examine if the pharmacological manipulations applied later in the postnatal period have any effect in the mature brain. |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To employ immuno-hybridization histochemical methods to map the spatiotemporal distribution of different activated glial cells during the development of PD as induced by systemic administration of a neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). |
| Project Title: | Development of commissural inhibition in the vestibular system |
| Investigator(s): | Chan YS, Yung KKL, Yung WH |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 01/2005 |
| Abstract: |
| To map the postnatal maturation time and the location of canal-related neurons in the vestibulo-olivary pathway; to document the location and maturation profile of inhibitory neuronal correlates in the commissural otolith pathway; to examine the developmental change of inhibitory postsynaptic current (IPSC) at central GABAergic synapses in brainstem slices containing the vestibular nucleus. |
| Project Title: | Development of commissural inhibition in the vestibular system |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| List of Research Outputs |
| Chan W.S., Chen L., Yung K.K. and Chan Y.S., Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 847.13. |
| Chan Y.S., Lai C.H., Ng K.Y. and Shum D.K.Y., Development and compensation of the gravity sensing system: Implications on neural plasticity, In: X.M. Wang et al. (Eds) Progress in Neuroscience. Higher Education Press, Beijing. 2004, 39-55. |
| Chan Y.S., Development of the gravity sensing system: Spatial coding and glutamate transmission, Proceedings of the 10th Scientific Conference of Thai Neuroscience Society. 2004, 4. |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Chau C.H., Liu J., Chan Y.S. and Shum D.K.Y., Expression of chondroitin sulfotransferases in the injured spinal cord, Soc. Neuroscience Abstract (U.S.A.). 2004, 43.6. |
| Chen L., Chan Y.S. and Yung W.H., GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizure, J. Biomedical Science. 2004, 11: 457-464. |
| Chen L., Hu H.J., Lin H.L., Yung K.K. and Chan Y.S., Identification of BDNF in nestin-expressing astroglial cells in the neostriatum of MPTP-treated mice, Neuroscience. 2004, 126: 941-953. |
| Kwok J.C.F., Ng K.Y., Zhang F., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates restrict axonal growth along the projection path of vestibular nuclear neurons across the hindbrain of prenatal rats, Neuroscience Letters. 2004, 370 Suppl: S13–14. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Postnatal expression of Fos in otolith-related brainstem neurons of rats following off-vertical axis rotation, J. Comparative Neurology. 2004, 470: 282-296. |
| Lai C.H., Lai S.K., Zhang F. and Chan Y.S., Postnatal expression of tyrosine kinase B in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 26. |
| Lai C.H. and Chan Y.S., Signaling capacity of peripheral and central otolith neurons in coding horizontal head movement in postnatal rats, Journal of Vestibular Research. 2004, 14: 262-263. |
| Lai S.K., Lai C.H. and Chan Y.S., Different expression pattern of NMDA and AMPA glutamate receptor subunits in group y neurons responsive to vertical linear acceleration, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.16. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of EAAC1 and glutamate receptor subunits in vestibular nuclear neurons responsive to vertical linear acceleration, Journal of Vestibular Research. 2004, 114. |
| Lam R.W., Chan Y.S. and Yung K.K., Differential localization of metabotropic glutamae receptors 1 and 2/3 in the rat striatum during early postnatal development, Neuroembryology and Aging. 2005, 3: 36-41. |
| Lam T.P., Khoo U.S., Chan Y.S., Cheng Y.H. and Lam K.F., The first batch of graduates of a new medical curriculum in Asia: how their teachers see them, Medical Education. 2004, 38(9): 980-986. |
| Lau J.W.K., Chan Y.S. and Yung K.K., Developmental assembly of Gamma-aminobutyric acid receptors in the rat substantia nigra, Proceedings of the 10th Scientific Congress of Thai Neuroscience Society. 2004, 27. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Li C., Lai C.H. and Chan Y.S., Postnatal development of glutamate receptors in otolith neurons in the rat dorsomedial cell column, Neuroscience Letters. 2004, 14: 263. |
| Li C., Guan Z., Chan Y.S. and Zheng Y., Projections from facial nucleus interneurons to the respiratory groups of brainstem neurons in the rat, Neuroscience Letters. 2004, 368: 25-28. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Li C., Zhang Y.K., Guan Z.L., Shum D.K.Y. and Chan Y.S., Vestibular afferent innervation in the efferent vestibular nucleus of rats, Neuroscience Letters. 2005, 385: 36-40. |
| Ng K.Y., Lai C.H. and Chan Y.S., Expression of GABAB receptors in vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Supp: S10-11. |
| Sun X., Chan Y.S. and He J., Cortical activation on temporal expression of Fos in various nuclei of the medial geniculate body of cochlear-ablated rats., Neuroscience Letters. 2004, 370 Suppl: S11. |
| Sun X., Chan Y.S. and He J.F., Fos expression in the medial geniculate body of cochlear-ablated and cortical-activated rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 305.22. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Suppl: S9. |
| Xiong Y., Yu Y.Q., Chan Y.S. and He J.F., In-vivo intracellular responses of the medial geniculate neurones to acoustic stimuli, Journal of Physiology. 2004, 560: 191-205. |
| Yu Y.Q., Xiong Y., Chan Y.S. and He J.F., Effects of cortical stimulation on auditory-responsive thalamic neurones: an in-vivo intracellular study, Journal of Physiology. 2004, 560: 207-217. |
| Zhang F., Lai C.H., Li J.L., Shum D.K.Y. and Chan Y.S., Expression of TrkA, TrkB and TrkC receptors in the central pathway of trigeminal proprioception in the rat, Acta Anatomica Sinica. 2004, 35: 249-252. |
| Researcher : Chen C |
| List of Research Outputs |
| Yu X.C., Wu S., Chen C., Pang K.T. and Wong T.M., Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat, J Pharm Pharmacol. 2004, 56(1): 115-22. |
| Researcher : Chen L |
| List of Research Outputs |
| Chan W.S., Chen L., Yung K.K. and Chan Y.S., Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 847.13. |
| Chen L., Chan Y.S. and Yung W.H., GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizure, J. Biomedical Science. 2004, 11: 457-464. |
| Chen L., Hu H.J., Lin H.L., Yung K.K. and Chan Y.S., Identification of BDNF in nestin-expressing astroglial cells in the neostriatum of MPTP-treated mice, Neuroscience. 2004, 126: 941-953. |
| Lee M.Y., Yung W.H., Chen L. and Chow B.K.C., Expression and spatial distribution of secretin and secretin receptor in human cerebellum, Neuroendocrinology. 2005, 16: 219-222. |
| Researcher : Chen M |
| List of Research Outputs |
| Cao C., Xia Q., Gao Q., Chen M. and Wong T.M., Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning, J Pharmacol Exp Ther. 2005, 312(2): 644-50. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Estrogen reduces cardiac injury and expression of beta 1 adrenoceptor upon ischemic insult in the rat heart, J Pharmacol Exp Ther. 2004, 309(1): 8-15. |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Wu S., Wong M.C.Y., Chen M., Cho C.H. and Wong T.M., Role of Opioid Receptors in Cardioprotection of Cold-Restraint Stress and Morphine, Journal of Biomedical Science. 2004, 11: 726-731. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology. 2005, 102(2): 371-8. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors, Anesthesiology. USA, 2005, 102: 371-378. |
| Researcher : Chung SSM |
| Project Title: | Osmoregulation in lens |
| Investigator(s): | Chung SSM |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Outstanding RGC Projects |
| Start Date: | 09/1998 |
| Abstract: |
| It is imperative to have a better understanding of the mechanisms leading to various cataracts such that preventive measures can be developed. Since maintaining the ionic strength and ionic composition in the lens is essential for the transparency of the lens, we plan to study the mechanism of osmoregulation in this organ. Transgenic mice that over-express aldose reductase and sodium dependent myoinositol transporter in their lenses will be used to increase the lens' level of sorbitol and myoinositol, respectively. We will determine if high level of these osmolytes causes cataract development, and see when the level of one osmolyte is high, will the lens compensate by reducing the level of other osmolytes. We will also determine whether high intracellular osmotic pressure affects the regulation of expression of genes that control the level of osmolytes such as aldose reductase, sodium dependent myoinositol transporter, and taurine transporter. |
| Project Title: | Effects of early postnatal feeding on fatty acid metabolism |
| Investigator(s): | Chung SSM, Sheng HP |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2002 |
| Abstract: |
| Both epidemiological studies and animal studies have shown that prenatal and early postnatal nutrition not only affects infant growth and development, it also predetermines future metabolism, performance adn morbidity. This study addresses the problems of nutritional environment during the sucking period on lipid metabolism and later-life obesity. |
| Project Title: | Mechanism of Nogo-A inhibition of axonal regeneration |
| Investigator(s): | Chung SSM, Chung SK, Ju G. |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2003 |
| Abstract: |
| To develop Nogo gene knockout mice to determine the role of this gene in the inhibition of axonal regeneration and its physiological functions; to develop transgenic mice that overexpress Nogo-A in their Schwann cells to determine if that would make their PNS non-permissive for axonal regeneraton; to develop transgenic mice that overexpress mutant Nogo-A with the Nogo-66 or aa623-640 region deleted to determine which domain is responsible for the inhibitory effect of Nogo-A. |
| Project Title: | Polyol pathway in diabetic dyslipidemia |
| Investigator(s): | Chung SSM |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2003 |
| Abstract: |
| To determine if AR null mutation reduces plasma TG levels in diabetic mice; to determine if ARI reduces plasma TG in diabetic mice; to determine if AR null mutation or ARI nor ARI normalizes LDL and HDL leviabetic mice. |
| Project Title: | Aldose reductase in diabetic cataract |
| Investigator(s): | Chung SSM |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
| Start Date: | 07/2003 |
| Abstract: |
| In the slow-developing diabetic cataract, chronic AR-induced oxidative stress impairs the lens' osmoregulatory machinery such that lens can no longer accommodate modest increase in sorbitol, leading to cataract development; We planned to test this model by determing if AR-induced osmotic stress and oxidative stress are both important for the pathogenesis of the slow developing cataract; to determine if osmotic stress and oxidative stress act synergistically to cause cataract development ; to investigate how the impairment in the epithelial cells affects the protein aggregation in the underlying fiber cells to cause lens opacity; to characterize the changes in the epithelial cells during cataract development. |
| Project Title: | Aldose reductase in diabetic cataract |
| Investigator(s): | Chung SSM |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 10/2004 |
| Abstract: |
| To determine if the antioxidant can prevent AR-induced slow-developing cataract; to determine the osmolyte content and oxidative status of the slow-developing cataract; to compare the morphological changes in the acute diabetic cataract and the slow developing cataract; to determine if there is apoptosis in the epithelial cells of the precataractous lenses. |
| Project Title: | Aldose reductase in diabetic cataract |
| Investigator(s): | Chung SSM |
| Department: | Institute of Molecular Biology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| Researcher : Das R |
| List of Research Outputs |
| Tsang S., Wu S., Wong S.S.C., Das R. and Wong T.M., Cross-talk between testosterone and adrenergic receptors in the rat heart, J Hong Kong College Cardiol. 2004, 12:96. |
| Researcher : Fung ML |
| Project Title: | Angiotensin II receptors in the carotid body: its function and expression in perinatal and postnatal hypoxia |
| Investigator(s): | Fung ML, Leung P.S. |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2001 |
| Completion Date: | 08/2004 |
| Abstract: |
| To determine the functional change upon the activation of ATRs in rat carotid body during chronic hypoxia from birth; to measure the intracellular calcium Ca++i response to the activation of ATRs in type I (gloumus) cells dissociated from the carotid body in normoxi and CH rats; to determine the transcriptional changes of the gene expression of ATRs in the carotid body with chronic hypoxia; to determine the localization of the ATRs in normoxic and CH carotid body. |
| Project Title: | Molecular and cellular mechanisms underlying anatomical and physiological adaption of the carotid body in chronic hypoxia: role of HIF-1 and its target genes |
| Investigator(s): | Fung ML, Tipoe GL, Fung PCW |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2002 |
| Abstract: |
| This project is an experimental study to examine the hypothesis that HIF-1 plays a paramount role in the transcriptional regulation of the structural and physiological adaptation of the carotid body in chronic hypoxia. In particular, the team will go into the increased expression and activities of HIF-1 and the activation of expression of HIF-1 target genes for encoding proteins, such as endothelin-1, vascular endothelial growth factor (VEGF), VEGF receptors and inducible nitric oxide synthase in the rat carotid body during chronic hypoxia. |
| Project Title: | Mechanistic role of protein S-nitrosylation pathway in cellular responses to oxygen signalling |
| Investigator(s): | Fung ML, Gao T.M. |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 12/2002 |
| Completion Date: | 11/2004 |
| Abstract: |
| To examine the role of redox state and NO-activated cGMP-independent pathway in modulating channel functions in different Oxgyen tensions; to determine the specificity of S-nitrosylation in mediating cGMP-independent NO-effects on the channel functions in different Oxgyen tensions; to determine S-nitrosylated mediators for modulating the channel functions and the role of redox state in setting the channel sensitivity to S-nitrosylating modulation in different Oxygen tensions; to examine the role of protein S-nitrosylation pathway in modulating cellular functions in tissue and organ levels in different Oxygen tensions. |
| Project Title: | Mechanistic role of carotid body afferent activity in the modulation of glutamatergic transmission in the nucleus tractus solitarii of rats in chronic hypoxia |
| Investigator(s): | Fung ML, Denoroy L., Pequignot J.M. |
| Department: | Physiology |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2004 |
| Completion Date: | 12/2004 |
| Abstract: |
| To examine the modulation of the N-methyl-D-aspartate (NMDA)-glutamate receptor/nitric oxide (NO) pathway in the NTS of rats in chronic hypoxia; to determine the role of carotid body afferent activity in the change of NMDA/NO pathway in the NTS of rats in chronic hypoxia. |
| Project Title: | Physiological roles of melatonin in circadian modulation of carotid chemoreceptor functions |
| Investigator(s): | Fung ML, Tipoe GL |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2004 |
| Completion Date: | 02/2005 |
| Abstract: |
| To delineate (1) the physiological pathway pathway underlying the circadian modulation of cardiopulmonary activities and (2) the cellular and molecular mechanisms mediating the physiological effects of melatonin on the carotid body function and its modulation during chronic hypoxia. |
| Project Title: | Expression and function af AT4 receptors in the carotid body in hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2005 |
| Abstract: |
| refer to hard copy proposal |
| List of Research Outputs |
| Chen Y., Tjong Y.W., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin enhances the hypoxic response of rat carotid body chemoreceptor, Journal of Pineal Research. 2005, 38: 157-163. |
| Fung M.L., Editorial Advisory Board Member, In: Atta-ur-RahmanK. ZamanMatthew Honan, Recent Patent Reviews on Cardiovascular Drug Discovery. Bentham Science Publishers Ltd., 2005. |
| Fung M.L., Hypoxia, carotid chemoreceptor and exercise training, The 8th Asian Federation of Sports Medicine Congress, Tokyo, Japan, S10-1, p.82. 2005. |
| Lam S.S.Y., Liong E.C., Tipoe G.L. and Fung M.L., Expression of HIF-2a and HIF-3a in the rat carotid body in chronic hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan. 2005, P4: p60. |
| Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Hypoxia-inducible factor (HIF)-1a and endothelin-1 expression in the rat carotid body during intermittent hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan, P3, p.59. 2005. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Increased expression of angiotensin II receptor and oxidative stress in the rat carotid body during intermittent hypoxia, Taiwan-Hong Kong International Symposium on Neural Physiology, Tainan, Taiwan. 2004. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Intermittent hypoxia increases AT1 receptor and oxidative stress in the rat carotid body, 6th World Congress on Mountain Medicine & High Altitude Physiology, 2004, Xining, Qinghai, China. (High Altitude Medicine & Biology . 2004, 5(2): 238. |
| Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Protein expression of HIF-1a and endothelin-1 in the rat carotid body in chronic and intermittent hypoxia. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P17, 2004. Journal of the Hong Kong College of Cardiology 12(3/4). 2004, 103. |
| Lau T.H.Y., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M., Nanji A.A. and Tipoe G.L., Hepatic vascular vasodilatory response to chronic hypoxia via nitric oxide. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P16, 2004. (Journal of the Hong Kong College of Cardiology, 12(3/4):103. 2004. |
| Lau T.H.Y., Fung M.L., Tom W.M., Nanji A.A. and Tipoe G.L., Mediation of glucose transporters in hepatic adaptation to chronic hypoxia via hypoxia inducible factor, 9th Research Postgraduate Symposium, HKU. 2004. |
| Lau T.H.Y., Tipoe G.L., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors and hypoxia-inducible genes mediate the hepatic vascular adaptive response to chronic hypoxia, Pathological Society of Great Britain and Ireland, Meeting Journal of Pathology, Suppl.. 2005, 205: 11-11. |
| Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005. |
| Leung T.M., Tipoe G.L., Lau T.H.Y., Liong E.C., So H., Leung K.M., Leung W.M., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model, Society of Pathology Meeting, 2005 Journal of Pathology, Suppl. . 2005, 205: 11-11. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich, P15. 2004. |
| Tipoe G.L., Lau T.Y.H., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors mediate hepatic vascular adaptive responses in chronic hypoxia, 55th Annual Meeting of AASLD, Boston . 2004. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Role of nitric oxide pathways in the rat hippocampal calcium response to energy deprivation, Taiwan-Hong Kong International Symposium on Neural Physiology 2004, Tainan. 2004. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Roles of calcium channels in nitric oxide pathways involved in hippocampal calcium response to hypoxia, The 3rd Symposium on Neuroscience for Young Scholars Worldwide Guangzhou, China. 2004. |
| Researcher : Guan Z |
| List of Research Outputs |
| Li C., Guan Z., Chan Y.S. and Zheng Y., Projections from facial nucleus interneurons to the respiratory groups of brainstem neurons in the rat, Neuroscience Letters. 2004, 368: 25-28. |
| Researcher : Hwang ISS |
| List of Research Outputs |
| Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., Ether stress increases adrenomedulin gene expression and levels in the rat adrenal, Horm. Metab. Res.. 2005, 37: 1-4. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich, P15. 2004. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., The effects of ether stress on the plasma and adrenal levels of adrenomedullin in intact rats and in rats without adrenal medulla, The 12th International Congress of Endocrinology, Lisbon. P233. 2004. |
| Researcher : Ip SF |
| List of Research Outputs |
| Chen Y., Tjong Y.W., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin enhances the hypoxic response of rat carotid body chemoreceptor, Journal of Pineal Research. 2005, 38: 157-163. |
| Researcher : Kam WL |
| List of Research Outputs |
| Kam W.L., Effect of ovariectomy and estrogen replacement on the b- adrenergic receptor signaling pathway and interacellular Ca 2+ homeostasis in the rat heart. 2005. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Estrogen reduces cardiac injury and expression of beta 1 adrenoceptor upon ischemic insult in the rat heart, J Pharmacol Exp Ther. 2004, 309(1): 8-15. |
| Kam W.L., Kravtsov G.M., Liu J. and Wong T.M., Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ vchannels in the heart from ovariectomized rats, Br J Pharmacol. 2005, 144(7): 972-81. |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Liu J., Borchert G.H., Kam W.L. and Wong T.M., Preconditioning restores calcium homeostasis by increasing HSP70 synthesis in the rat heart, J Hong Kong College Cardiol. 2004, 12:107. |
| Researcher : Kravtsov GM |
| List of Research Outputs |
| Kam W.L., Kravtsov G.M., Liu J. and Wong T.M., Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ vchannels in the heart from ovariectomized rats, Br J Pharmacol. 2005, 144(7): 972-81. |
| Researcher : Kui CY |
| List of Research Outputs |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Suppl: S9. |
| Researcher : Lai CH |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Ng K.Y. and Shum D.K.Y., Development and compensation of the gravity sensing system: Implications on neural plasticity, In: X.M. Wang et al. (Eds) Progress in Neuroscience. Higher Education Press, Beijing. 2004, 39-55. |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Postnatal expression of Fos in otolith-related brainstem neurons of rats following off-vertical axis rotation, J. Comparative Neurology. 2004, 470: 282-296. |
| Lai C.H., Lai S.K., Zhang F. and Chan Y.S., Postnatal expression of tyrosine kinase B in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 26. |
| Lai C.H. and Chan Y.S., Signaling capacity of peripheral and central otolith neurons in coding horizontal head movement in postnatal rats, Journal of Vestibular Research. 2004, 14: 262-263. |
| Lai S.K., Lai C.H. and Chan Y.S., Different expression pattern of NMDA and AMPA glutamate receptor subunits in group y neurons responsive to vertical linear acceleration, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.16. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of EAAC1 and glutamate receptor subunits in vestibular nuclear neurons responsive to vertical linear acceleration, Journal of Vestibular Research. 2004, 114. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Li C., Lai C.H. and Chan Y.S., Postnatal development of glutamate receptors in otolith neurons in the rat dorsomedial cell column, Neuroscience Letters. 2004, 14: 263. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Ng K.Y., Lai C.H. and Chan Y.S., Expression of GABAB receptors in vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Supp: S10-11. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Suppl: S9. |
| Zhang F., Lai C.H., Li J.L., Shum D.K.Y. and Chan Y.S., Expression of TrkA, TrkB and TrkC receptors in the central pathway of trigeminal proprioception in the rat, Acta Anatomica Sinica. 2004, 35: 249-252. |
| Researcher : Lai SK |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Lai C.H., Lai S.K., Zhang F. and Chan Y.S., Postnatal expression of tyrosine kinase B in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 26. |
| Lai S.K., Lai C.H. and Chan Y.S., Different expression pattern of NMDA and AMPA glutamate receptor subunits in group y neurons responsive to vertical linear acceleration, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in rats, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.16. |
| Lai S.K., Lai C.H. and Chan Y.S., Postnatal expression of EAAC1 and glutamate receptor subunits in vestibular nuclear neurons responsive to vertical linear acceleration, Journal of Vestibular Research. 2004, 114. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Researcher : Lam SSY |
| List of Research Outputs |
| Lam S.S.Y., Liong E.C., Tipoe G.L. and Fung M.L., Expression of HIF-2a and HIF-3a in the rat carotid body in chronic hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan. 2005, P4: p60. |
| Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Hypoxia-inducible factor (HIF)-1a and endothelin-1 expression in the rat carotid body during intermittent hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan, P3, p.59. 2005. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Increased expression of angiotensin II receptor and oxidative stress in the rat carotid body during intermittent hypoxia, Taiwan-Hong Kong International Symposium on Neural Physiology, Tainan, Taiwan. 2004. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Intermittent hypoxia increases AT1 receptor and oxidative stress in the rat carotid body, 6th World Congress on Mountain Medicine & High Altitude Physiology, 2004, Xining, Qinghai, China. (High Altitude Medicine & Biology . 2004, 5(2): 238. |
| Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Protein expression of HIF-1a and endothelin-1 in the rat carotid body in chronic and intermittent hypoxia. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P17, 2004. Journal of the Hong Kong College of Cardiology 12(3/4). 2004, 103. |
| Researcher : Lau JWK |
| List of Research Outputs |
| Lau J.W.K., Chan Y.S. and Yung K.K., Developmental assembly of Gamma-aminobutyric acid receptors in the rat substantia nigra, Proceedings of the 10th Scientific Congress of Thai Neuroscience Society. 2004, 27. |
| Researcher : Li C |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Li C., Lai C.H. and Chan Y.S., Postnatal development of glutamate receptors in otolith neurons in the rat dorsomedial cell column, Neuroscience Letters. 2004, 14: 263. |
| Li C., Guan Z., Chan Y.S. and Zheng Y., Projections from facial nucleus interneurons to the respiratory groups of brainstem neurons in the rat, Neuroscience Letters. 2004, 368: 25-28. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Li C., Zhang Y.K., Guan Z.L., Shum D.K.Y. and Chan Y.S., Vestibular afferent innervation in the efferent vestibular nucleus of rats, Neuroscience Letters. 2005, 385: 36-40. |
| Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Researcher : Li C |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Li C., Lai C.H. and Chan Y.S., Postnatal development of glutamate receptors in otolith neurons in the rat dorsomedial cell column, Neuroscience Letters. 2004, 14: 263. |
| Li C., Guan Z., Chan Y.S. and Zheng Y., Projections from facial nucleus interneurons to the respiratory groups of brainstem neurons in the rat, Neuroscience Letters. 2004, 368: 25-28. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Li C., Zhang Y.K., Guan Z.L., Shum D.K.Y. and Chan Y.S., Vestibular afferent innervation in the efferent vestibular nucleus of rats, Neuroscience Letters. 2005, 385: 36-40. |
| Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Researcher : Li GR |
| Project Title: | Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
| Investigator(s): | Li GR, Lau CP, Chiu SW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 12/2001 |
| Abstract: |
| To determine the intracellular signaling pathways that regulate ICl.vol and cell volume in human atrium; to determine whether ICl.vol is persistently activated in atrial myocytes from patients with dilated atrial cardiomyopathy. |
| Project Title: | Effects of calcium channel blockers on repolarization potassium currents in human atrial cells |
| Investigator(s): | Li GR, Chiu S.W. |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To evaluate the effects of diltiazem and verapamil on I[to1] and I[Kur] in human atrial cells. |
| Project Title: | Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation |
| Investigator(s): | Li GR, Lau CP, Chung SSM, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 12/2003 |
| Abstract: |
| To analyze the molecular identities of IKDR, IKCa, and INa in MSCs from rat bone marrow with semi-quantitative reverse transcript-polymeterase chain reaction (RT-PCR) and patch clamp techniques; to test the hypothesis that the three types of channels (IKDR, IKCa and INa) are involved in the proliferation of rat MSCs by determining cell proliferation in the absence and presence of channel blockers and modulators. |
| Project Title: | Effects of the compound a from the TCM Xuelianhua on Ionic channel currents in cardiac myocytes |
| Investigator(s): | Li GR, Lau CP |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 12/2003 |
| Completion Date: | 11/2004 |
| Abstract: |
| To study : (1) the effects of the compound A on inward sodium current INa and calcium current (ICa); (2) effects of the compound A on outward repolarization currents, i.e. inwardly-rectifying potassium current (IK1), rapid and slow delayed rectifier potassium currents (IKr and IKs) in guinea pig and goad ventricular myocytes. |
| Project Title: | Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation |
| Investigator(s): | Li GR, Lau CP, Chung SSM, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 12/2003 |
| Abstract: |
| To analyze the molecular identities of IKDR, IKCa, and INa in MSCs from rat bone marrow with semi-quantitative reverse transcript-polymeterase chain reaction (RT-PCR) and patch clamp techniques; to test the hypothesis that the three types of channels (IKDR, IKCa and INa) are involved in the proliferation of rat MSCs by determining cell proliferation in the absence and presence of channel blockers and modulators. |
| Project Title: | Potassium channel gene transfer in cardiomypathic failing heart - a possible gene therapy strategy for electrophysiological remodeling |
| Investigator(s): | Li GR |
| Department: | Medical Faculty |
| Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
| Start Date: | 07/2004 |
| Abstract: |
| Refer to hard copy |
| Project Title: | Modulation of cloned human cardiac potassium channel by protein tyrosine kinase |
| Investigator(s): | Li GR |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To clarify specific PTK pathway that is involved in the modulation of IKs channels. |
| Researcher : Li YY |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., Adenomedullin expression and cytokine response in experimentally induced endotoxaemia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. P16. 2004. |
| Cheung B.M.Y., Li Y.Y. and Wong L.Y.F., Adrenomedullin: Its Roles in the Cardiovascular System, Seminars Vasc Med. 2004, 4(2): 129-134. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., Ether stress increases adrenomedulin gene expression and levels in the rat adrenal, Horm. Metab. Res.. 2005, 37: 1-4. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., The effects of ether stress on the plasma and adrenal levels of adrenomedullin in intact rats and in rats without adrenal medulla, The 12th International Congress of Endocrinology, Lisbon. P233. 2004. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. S20. 2004. |
| Researcher : Li YY |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., Adenomedullin expression and cytokine response in experimentally induced endotoxaemia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. P16. 2004. |
| Cheung B.M.Y., Li Y.Y. and Wong L.Y.F., Adrenomedullin: Its Roles in the Cardiovascular System, Seminars Vasc Med. 2004, 4(2): 129-134. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., Ether stress increases adrenomedulin gene expression and levels in the rat adrenal, Horm. Metab. Res.. 2005, 37: 1-4. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., The effects of ether stress on the plasma and adrenal levels of adrenomedullin in intact rats and in rats without adrenal medulla, The 12th International Congress of Endocrinology, Lisbon. P233. 2004. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. S20. 2004. |
| Researcher : Liu J |
| List of Research Outputs |
| Kam W.L., Kravtsov G.M., Liu J. and Wong T.M., Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ vchannels in the heart from ovariectomized rats, Br J Pharmacol. 2005, 144(7): 972-81. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Liu J., Borchert G.H., Kam W.L. and Wong T.M., Preconditioning restores calcium homeostasis by increasing HSP70 synthesis in the rat heart, J Hong Kong College Cardiol. 2004, 12:107. |
| Researcher : Liu J |
| List of Research Outputs |
| Kam W.L., Kravtsov G.M., Liu J. and Wong T.M., Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ vchannels in the heart from ovariectomized rats, Br J Pharmacol. 2005, 144(7): 972-81. |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Liu J., Borchert G.H., Kam W.L. and Wong T.M., Preconditioning restores calcium homeostasis by increasing HSP70 synthesis in the rat heart, J Hong Kong College Cardiol. 2004, 12:107. |
| Researcher : Lung MAKY |
| Project Title: | Endodthelium-dependent relaxation in nasal mucosa: relative role of multiple factors in the regulation of vascular tone |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To study the role of each of the endothelium-derived relaxing factors in the control of the vascular tone of different segments of the nasal vascular bed. |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To investigate the role of endothelins on the nasal mucosa, eliciting nasal congestion or decongestion, as well as the underlying vascular events and control mechanisms. |
| List of Research Outputs |
| Lung M.A.K.Y., The effect of sulfur dioxide inhalation on the nasal responsiveness to acetylcholine and histamine, 8th Scientific Meeting of the Hong Kong Pharmacology Society in association with the Shanghai Pharmacology Society, August 16 - 17, 2004, Hong Kong. 2004, P19:P3. |
| Lung M.A.K.Y. and Wang J.C.C., The role of nitric oxide and prostanoids in the control of basal vascular resistance and airway resistance, 8th Scientific Meeting of the Hong Kong Pharmacology Society in association with the Shanghai Pharmacology Society, August 16 - 17, 2004, Hong Kong. 2004, p21:P5. |
| Lung M.A.K.Y. and Wang M., Vasocontractile and vasorelaxant muscarinic receptors in canine nasal venous vessels, Proceedings of the Chinese Pharmacological Society Meeting 2005, May 9 - 12, 2005, Xian, China. 2005. |
| Researcher : Lung MKY |
| Project Title: | Endodthelium-dependent relaxation in nasal mucosa: relative role of multiple factors in the regulation of vascular tone |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To study the role of each of the endothelium-derived relaxing factors in the control of the vascular tone of different segments of the nasal vascular bed. |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To investigate the role of endothelins on the nasal mucosa, eliciting nasal congestion or decongestion, as well as the underlying vascular events and control mechanisms. |
| Researcher : Man SY |
| List of Research Outputs |
| Man S.Y., Adrenomedullin in the Rat Digestive System: Response to Starvation. 2005. |
| Researcher : Ng KY |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Ng K.Y. and Shum D.K.Y., Development and compensation of the gravity sensing system: Implications on neural plasticity, In: X.M. Wang et al. (Eds) Progress in Neuroscience. Higher Education Press, Beijing. 2004, 39-55. |
| Kwok J.C.F., Ng K.Y., Zhang F., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates restrict axonal growth along the projection path of vestibular nuclear neurons across the hindbrain of prenatal rats, Neuroscience Letters. 2004, 370 Suppl: S13–14. |
| Ng K.Y., Lai C.H. and Chan Y.S., Expression of GABAB receptors in vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Supp: S10-11. |
| Researcher : Poon AMS |
| Project Title: | Regulation of the differentiation of rat endometrial stromal cells by melatonin in early pregnancy |
| Investigator(s): | Poon AMS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| Completion Date: | 04/2005 |
| Abstract: |
| refer hard copy proposal |
| List of Research Outputs |
| Cheung K.M.C., Wang T., Poon A.M.S., Carl A., Tranmer B., Hu Y.G., Luk K.D.K. and Leong J.C.Y., Pinealectomy in young non-human primates does not result in scoliosis development: a long term follow-up study, 39th Annual Meeting of the Scoliosis Research Society, Buenos Aires, Argentina, September 6-9, 2004. |
| Cheung W.Y., Cheung K.M.C., Ting W., Poon A.M.S., Carl A., Tranmer B., Hu Y.G., Luk K.D.K. and Leong J.C.Y., Pinealectomy in young non-human primates does not result in scoliosis development: a long term follow-up study, 24th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 13-14, 2004. |
| Poon A.M.S. and Mak A.S.Y., A review on he legislative regulations and potential health hazards; its relevance to family physicians, The Hong Kong Practitioner . 2005, May; 27(5): 192-196. |
| Researcher : Qi J |
| List of Research Outputs |
| Kam W.L., Qi J., Chen M. and Wong T.M., Estrogen reduces cardiac injury and expression of beta 1 adrenoceptor upon ischemic insult in the rat heart, J Pharmacol Exp Ther. 2004, 309(1): 8-15. |
| Researcher : Shiu SYW |
| Project Title: | Role of PDZD2 in the modulation of prostate cancer cell proliferation |
| Investigator(s): | Shiu SYW, Yao KM |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To determine the expression of full-length and secreted forms of PDZD2 in common prostate cancer cell lines; to detect any changes in the expression of the full-length and secreted forms of PDZD2 upon hormonal stimulation of prostate cancer cell proliferation; to study the effect of decreased endogenous expression of PDZD2 on prostate cancer cell proliferation. |
| Project Title: | sPDZD2-induced protein profile changes in prostate cancer |
| Investigator(s): | Shiu SYW, Yao KM |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To express and purify sPDZD2 in E. coli, and to study the effects of the recombinant protein on the protein profiles of human prostate cancer to cells using a 'proteomics' approach. |
| List of Research Outputs |
| Tam C.W., Yao K.M. and Shiu S.Y.W., Anti-proliferative effects of PDZD2 and its secreted protein sPDZD2 on prostate cancer cells, HKU 9th Research Postgraduate Symposium. 2004, 2004: 2.08. |
| Tam C.W., Yao K.M. and Shiu S.Y.W., Potential roles of PDZD2 in prostate cancer pathogenesis, Taiwan-Hong Kong International Symposium on Neural Physiology. 2004, 2004: 16. |
| Researcher : Tam CW |
| List of Research Outputs |
| Tam C.W., Yao K.M. and Shiu S.Y.W., Anti-proliferative effects of PDZD2 and its secreted protein sPDZD2 on prostate cancer cells, HKU 9th Research Postgraduate Symposium. 2004, 2004: 2.08. |
| Tam C.W., Yao K.M. and Shiu S.Y.W., Potential roles of PDZD2 in prostate cancer pathogenesis, Taiwan-Hong Kong International Symposium on Neural Physiology. 2004, 2004: 16. |
| Researcher : Tam LTL |
| List of Research Outputs |
| Tam L.T.L. and Ballard H.J., The influence of acute, chronic or chronic intermittent hypoxia on NO release from the renal circulation, Journal of the Hong Kong College of Cardiology. 2004, 12: 92. |
| Tam L.T.L., The influence of acute, chronic or chronic intermittent hypoxia on NO release from the renal circulation, MPhil thesis. 2004. |
| Researcher : Tang F |
| Project Title: | The effect of ageing on the response of the adrenomedullin system to hypoxia in the rat |
| Investigator(s): | Tang F, Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Completion Date: | 10/2004 |
| Abstract: |
| To investigate the age-related changes in the levels of adenomedullin and preproAM mRNA levels in the lung, the heart and blood vessels and their responses to acute and chronic hypoxia. |
| Project Title: | The gene expression and levels of adrenomedullin in the ovary and the uterus of the rat: changes during the oestrous cycle and in pregnancy |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To study the mRNA and peptide levels of adrenomedullin in the ovary and the uterus in relation to the different stages of the oestrous cycle and in pregnancy. |
| Project Title: | Adrenomedullin in the rat testis: paracrine actions and its interaction with endothelin |
| Investigator(s): | Tang F, O WS, Wong P.Y.D. |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2004 |
| Abstract: |
| To study the gene expression and levels of adrenomedullin and also its receptors and binding in the whole testis and in the Leydig cells and Sertoli cells, and the types of receptor activity modifying proteins expressed in these cells which will determine whether these cells respond to adrenomedullin or CGRP or both; to investigate the effects of adrenomedullin on steoidogenesis in the Leydig cells, contraction of seminferous tubules and Sertoli cell secretion in the presence or absense of CGRP or endothelin, gonadotrophins and testosterone. |
| Project Title: | The effects of starvation on the gene expression and peptide levels of adrenomedullin in the gastrointestinal tract |
| Investigator(s): | Tang F, Sheng HP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To investigate the changes of adrenomedullin gene expression and peptide levels in the GI tract including the stomach, the liver, pancreas, ileum and colon in 1-day and 4-day starved rats compared with control fed rats; to study the changes in the gene expression levels of the receptors (CRLR) and the receptor activity modifying proteins, RAMP1 and RAMP2. |
| Project Title: | Adrenomedullin in the rat testis: paracrine actions and its interaction with endothelin |
| Investigator(s): | Tang F |
| Department: | Physiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., Adenomedullin expression and cytokine response in experimentally induced endotoxaemia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. P16. 2004. |
| Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Savenko A., Xu G., Melnilova T., Morton J.L., Gonzales V., Wong M.P., Price D.L. and Tang F., Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer’s disease; relationships to beta-amyloid deposition and neurotransmitter abnormalities., Neurobiol. Dis. 2005, 18: 602-617. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., Ether stress increases adrenomedulin gene expression and levels in the rat adrenal, Horm. Metab. Res.. 2005, 37: 1-4. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich, P15. 2004. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., The effects of ether stress on the plasma and adrenal levels of adrenomedullin in intact rats and in rats without adrenal medulla, The 12th International Congress of Endocrinology, Lisbon. P233. 2004. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. S20. 2004. |
| Wong L.Y.F., Cheung B.M.Y. and Tang F., Adrenomedullin is Both Proinflammatory and Antiinflammatory: Its Effects on Gene Expression and Secretion of Cytokines and Macrophage Migration Inhibitory Factor in NR8383 Macrophage Cell Line, Endocrinology. 2005, 146: 1321-1327. |
| Wong L.Y.F., Cheung B.M.Y. and Tang F., Expressions of Urotensin II and Urotensin II Receptor are Up-regulated in Cardiovascular Tissues in Experimentally Induced Endotoxaemia, American Journal of hypertension. 2005, 18: 125A. |
| Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004. |
| Zou L., Tang F. and Cheung R.T.F., Cerebral ischemia induces neuronal damage in APP/PS1 double transgenic mice via activation of JNK/P38 pathway, Society for Neuroscience 2004. 443.6. |
| Researcher : Tjong YW |
| List of Research Outputs |
| Chen Y., Tjong Y.W., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin enhances the hypoxic response of rat carotid body chemoreceptor, Journal of Pineal Research. 2005, 38: 157-163. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Increased expression of angiotensin II receptor and oxidative stress in the rat carotid body during intermittent hypoxia, Taiwan-Hong Kong International Symposium on Neural Physiology, Tainan, Taiwan. 2004. |
| Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Intermittent hypoxia increases AT1 receptor and oxidative stress in the rat carotid body, 6th World Congress on Mountain Medicine & High Altitude Physiology, 2004, Xining, Qinghai, China. (High Altitude Medicine & Biology . 2004, 5(2): 238. |
| Tjong Y.W., Mechanisms of endogenous nitric oxide production and intracellular pathways in rat hippocampal CA1 calcium response to hypoxia and in-vitro ischemia.. 2004. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Role of nitric oxide pathways in the rat hippocampal calcium response to energy deprivation, Taiwan-Hong Kong International Symposium on Neural Physiology 2004, Tainan. 2004. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Roles of calcium channels in nitric oxide pathways involved in hippocampal calcium response to hypoxia, The 3rd Symposium on Neuroscience for Young Scholars Worldwide Guangzhou, China. 2004. |
| Researcher : Tsang S |
| List of Research Outputs |
| Tsang S., Wu S., Wong S.S.C., Das R. and Wong T.M., Cross-talk between testosterone and adrenergic receptors in the rat heart, J Hong Kong College Cardiol. 2004, 12:96. |
| Researcher : Tse YC |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Postnatal expression of Fos in otolith-related brainstem neurons of rats following off-vertical axis rotation, J. Comparative Neurology. 2004, 470: 282-296. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Suppl: S9. |
| Tse Y.C., Postnatal representation of horizontal space in utricle-related central neurons: Orientation-specific maturation time and ionotropic glutamate receptor heterogeneity, PhD Theses. 2005. |
| Researcher : Tse YC |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Lai S.K., Li C. and Tse Y.C., Postnatal development of spatial coding in the gravity sensing system, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 5. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Postnatal expression of Fos in otolith-related brainstem neurons of rats following off-vertical axis rotation, J. Comparative Neurology. 2004, 470: 282-296. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Responsiveness of inferior olivary neurons to horizontal linear acceleration in developing rats, Neuroscience Letters. 2004, 370 Suppl: S10. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters. 2004, 370 Suppl: S9. |
| Tse Y.C., Postnatal representation of horizontal space in utricle-related central neurons: Orientation-specific maturation time and ionotropic glutamate receptor heterogeneity, PhD Theses. 2005. |
| Researcher : Wang G |
| List of Research Outputs |
| Wang G., Wang H., Yang Y. and Wong T.M., Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes, Eur J Pharmacol. 2004, 13;498(1-3): 53-8. |
| Researcher : Wong PF |
| List of Research Outputs |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., Ether stress increases adrenomedulin gene expression and levels in the rat adrenal, Horm. Metab. Res.. 2005, 37: 1-4. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich, P15. 2004. |
| Tang F., Wong P.F., Hwang I.S.S. and Li Y.Y., The effects of ether stress on the plasma and adrenal levels of adrenomedullin in intact rats and in rats without adrenal medulla, The 12th International Congress of Endocrinology, Lisbon. P233. 2004. |
| Researcher : Wong TM |
| Project Title: | Cardioprotective effects of female sex hormone as a result of negative modulation of [beta]-adrenoceptor - mechanisms of action |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 10/2001 |
| Completion Date: | 09/2004 |
| Abstract: |
| To test the hypothhesis that female sex hormone may produce cardioprotection by negatively modulating the [beta]-AR, the predominant receptor in the heart responding to the sympathetic nervous system; to determine whether the signaling pathway that mediates the rappid actions of estrogen, involves the messengers, known to mediate the action of membrane receptors. |
| Project Title: | Signaling mechanism of preconditioning with U50, 488H in the rat - the role of Katp channels |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Abstract: |
| To determine the roles of two types of KATP channels, mitochondrial and sarcolemmal in delayed cardioprotection of preconditioning with a [kappa] opioid receptor [kappa]-OR agonist, U50, 488H; to determine the relationship between KATP channels and heat shock protein 70 (HSP70), which has already been shown to mediate delayed cardioprotection of preconditioning with U50, 488H. |
| Project Title: | Ca2+ homeostasis and delayed cardioprotection of preconditioning with metabolic inhibition or kappa opioid receptor agonist: role of stress inducible heat shock protein and mitochondrial K ATP channel |
| Investigator(s): | Wong TM, Li GR, Sham J.S.K. |
| Department: | Physiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 09/2003 |
| Abstract: |
| To test the hypothesis that preconditioning with a kppa-OR agonist or MI, that confers delayed cardioprotection, prevents the elevations in cytoplasmic and mitochondrial Ca2+; to test the hypothesis that the HSP and K(ATP) channel, that mediates and triggers delayed cardioprotection of MIP and UP, respectively prevents the alterations in the Ca2+ handling induced by MI insult. |
| Project Title: | Ca2+ homeostasis and delayed cardioprotection of preconditioning with metabolic inhibition or kappa opioid receptor agonist: role of stress inducible heat shock protein and mitochondrial K ATP channel |
| Investigator(s): | Wong TM, Li GR, Sham J.S.K. |
| Department: | Physiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2003 |
| Abstract: |
| To test the hypothesis that preconditioning with a kppa-OR agonist or MI, that confers delayed cardioprotection, prevents the elevations in cytoplasmic and mitochondrial Ca2+; to test the hypothesis that the HSP and K(ATP) channel, that mediates and triggers delayed cardioprotection of MIP and UP, respectively prevents the alterations in the Ca2+ handling induced by MI insult. |
| Project Title: | Electrophysiological actions of morphine in the rodent and human heart |
| Investigator(s): | Wong TM, Cheung YF, Li GR |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Completion Date: | 10/2005 |
| Abstract: |
| To study the electrophysiological properties of morphine at clinical concentrations in human and rodent myocytes, and the involvement of opioid receptor subtype. |
| Project Title: | Effects of testosterone on intracellular Ca2 transient and its response to adrenoceptor stimulation |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To understand the role of T on the regulation of cardiac functions; to understand the interaction between T and ARs. |
| List of Research Outputs |
| Cao C., Xia Q., Gao Q., Chen M. and Wong T.M., Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning, J Pharmacol Exp Ther. 2005, 312(2): 644-50. |
| Cao C., Xia Q. and Wong T.M., Cardioprotection of interleukin-2 is mediated via k-opioid receptor, J Pharmacol Exp Ther . 2004, 309(2): 560-567. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Estrogen reduces cardiac injury and expression of beta 1 adrenoceptor upon ischemic insult in the rat heart, J Pharmacol Exp Ther. 2004, 309(1): 8-15. |
| Kam W.L., Kravtsov G.M., Liu J. and Wong T.M., Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ vchannels in the heart from ovariectomized rats, Br J Pharmacol. 2005, 144(7): 972-81. |
| Lai X.G., Yong J., Zhou S.S., Zhou J., Li G.R. and Wong T.M., Involvement of anion channel(s) in the modulation of the transient outward K(+) channel in rat ventricular myocytes, Am J Physiol Cell Physiol. 2004, 287: C163-C170. |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Liu J., Borchert G.H., Kam W.L. and Wong T.M., Preconditioning restores calcium homeostasis by increasing HSP70 synthesis in the rat heart, J Hong Kong College Cardiol. 2004, 12:107. |
| Maslov L.N., Lishmanov A.I.U., Solenkova N.V., Budankova E.V., Wong T.M., Chang W.C. and Bray L.X., The antiarrhythmic effect of (-)-U-50,488 in rats with acute ischemia and reperfusion of heart is mediated by kappa1-opioid receptor activation, Eksp Klin Farmakol. 2005, 68(1): 25-9. |
| Tsang S., Wu S., Wong S.S.C., Das R. and Wong T.M., Cross-talk between testosterone and adrenergic receptors in the rat heart, J Hong Kong College Cardiol. 2004, 12:96. |
| Wang G., Wang H., Yang Y. and Wong T.M., Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes, Eur J Pharmacol. 2004, 13;498(1-3): 53-8. |
| Wong T.M. and Cao C., Role of calcium activated potassium channel in cardioprotection of preconditioning – mechanisms of action, CAPS News Communication. 2005, 21(12) Suppl,3. |
| Wu S., Wong M.C.Y., Chen M., Cho C.H. and Wong T.M., Role of Opioid Receptors in Cardioprotection of Cold-Restraint Stress and Morphine, Journal of Biomedical Science. 2004, 11: 726-731. |
| Yu X.C., Wu S., Chen C., Pang K.T. and Wong T.M., Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat, J Pharm Pharmacol. 2004, 56(1): 115-22. |
| Zhang Y., Irwin M.G. and Wong T.M., Remifentanil Preconditioning Protects against Ischemic Injury in the Intact Rat Heart, Anesthesiology. USA, 2004, 101: 918-923. |
| Zhang Y., Chen Z.W., Irwin M.G. and Wong T.M., Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats, Acta Pharmacol Sin. 2005, 26(5): 546-50. |
| Zhang Y., Zhang Y., Irwin M.G. and Wong T.M., Remifentanil mimics the cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest rats, Acta Pharmacologica Sinica. 2005, 26: 546-550. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology. 2005, 102(2): 371-8. |
| Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors, Anesthesiology. USA, 2005, 102: 371-378. |
| Researcher : Wu S |
| List of Research Outputs |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Tsang S., Wu S., Wong S.S.C., Das R. and Wong T.M., Cross-talk between testosterone and adrenergic receptors in the rat heart, J Hong Kong College Cardiol. 2004, 12:96. |
| Wu S., Wong M.C.Y., Chen M., Cho C.H. and Wong T.M., Role of Opioid Receptors in Cardioprotection of Cold-Restraint Stress and Morphine, Journal of Biomedical Science. 2004, 11: 726-731. |
| Yu X.C., Wu S., Chen C., Pang K.T. and Wong T.M., Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat, J Pharm Pharmacol. 2004, 56(1): 115-22. |
| Researcher : Yan WY |
| List of Research Outputs |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |
| Researcher : Zhang F |
| List of Research Outputs |
| Kwok J.C.F., Ng K.Y., Zhang F., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates restrict axonal growth along the projection path of vestibular nuclear neurons across the hindbrain of prenatal rats, Neuroscience Letters. 2004, 370 Suppl: S13–14. |
| Lai C.H., Lai S.K., Zhang F. and Chan Y.S., Postnatal expression of tyrosine kinase B in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations, Proceedings of the 2nd Symposium of Federation of Asian-Oceanian Neuroscience Societies. 2004, 26. |
| Zhang F., Lai C.H., Li J.L., Shum D.K.Y. and Chan Y.S., Expression of TrkA, TrkB and TrkC receptors in the central pathway of trigeminal proprioception in the rat, Acta Anatomica Sinica. 2004, 35: 249-252. |
| Researcher : Zhou H |
| List of Research Outputs |
| Li C., Lai S.K., Zhou H., Liu J., Lai C.H. and Chan Y.S., Developmental responsiveness of rat dorsomedial cell column neurons to horizontal and vertical linear acceleration, Soc. Neuroscience Abstract (U.S.A.). 2004, 652.4. |
| Researcher : Zhou J |
| List of Research Outputs |
| Liu J., Kam W.L., Zhou J., Yan W.Y., Chen M., Wu S. and Wong T.M., Effects of HSP70 activation by metabolic inhibition preconditioning or k -OR stimulation on Ca homeostasis in rat ventricular myocytes subjected to ischemic insults, J Pharmacol Exp Ther. 2004, 310 (2): 606-613. |