Dept of Anatomy

DEPARTMENT OF ANATOMY

Researcher : Chan HC

List of Research Outputs

So K.F., Chan H.C., Chang R.C.C., Chan Y.M.S., Yuen W.H. and Zee S.S.Y., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceutical, Guangzhou, China. 2004, 15.

Researcher : Chan YF

List of Research Outputs

Chan Y.F., Wu W., McCoy J., Pepinsky B., Sha M. and So K.F., LINGO-1 rescues retinal ganglion cells after optic nerve transaction, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 749.5.

Researcher : Chan YMS

List of Research Outputs

So K.F., Chan H.C., Chang R.C.C., Chan Y.M.S., Yuen W.H. and Zee S.S.Y., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceutical, Guangzhou, China. 2004, 15.

Researcher : Chang RCC

Project Title:	Caspase-3 as an upstream signaling molecule for translational control in neuronal apoptosis: implications of [beta]-amyloid peptides-induced neuronal apoptosis
Investigator(s):	Chang RCC, Chung SK, Hugon J
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To identify the modes and the underlying mechanisms of activation for PKR-eIF2[alpha] pathway in neurons, which are relevant to A[beta] peptides toxicity.

Project Title:	Molecular Signaling of Neuronal Death in Alzheimer's Disease
Investigator(s):	Chang RCC, Hugon J.
Department:	Anatomy
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2004
Completion Date:	12/2004

Abstract:

To elucidate the molecular signaling pathways leading to neuronal death in A[beta] peptide neurotoxicity and neurodegeneration in Alzheimer's disease.

Project Title:	Roles of tumor necrosis factor receptor (TNFR1) and Fas in modulating double-stranded RNA-dependent protein kinase (PKR) in neurons upon [beta]-amyloid peptide toxicity and in Alzheimer's disease
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To examine whether there is any difference for the signaling of TRADD, TRAF2 and RIP1. There are some lines of evidence showing that TRAF2 and RIP1 exert different downstream signaling pathways althrough they both contain the death domain.

Project Title:	Re-evaluation of the molecular mechanisms of ER stress responses in Beta-amyloid peptide-induced neurotoxicity and Alzheimer's disease
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Molecular signaling of neuronal autophagy in Alzheimer's disease
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

Key issues and problems being addressed:One major direction for the treatment of Alzheimer’s disease (AD) is to inhibit the acetylcholinesterase to preserve neurotransmitter for memory. However, if neurons in AD undergo degeneration, preservation of acetylcholine is not a good therapeutic method. Alternative strategies to safeguard neurons should be further explored. Signaling leads to degeneration and neuronal death is an important issue to be investigated in AD research. One mode of neuronal death receiving increased attention is the granulovacuolar degeneration (GVD). It has been reported that GVD is found in AD brain tissues. Autophagic processes leading to the formation of vacuoles in the cells have been considered to be both protective to prevent tumor formation and a type-II programmed cell death. Autophagy can avoid accumulation of damaged organelles in neurons. However, long-term autophagic processes in GVD can lead to type II programmed cell death, a caspase-independent mode of death. Therefore, autophagic processes in GVD can be considered to be the struggling between neuronal death and survival. Occurrence of GVD may explain why actual neuronal death in AD can last for many years, which is different to experimental study. GVD could be a key factor to determine the fate of neurons in AD. The signaling events initiating GVD in AD are largely unclear. We and other laboratories have shown the puntated staining for phosphorylated double-stranded RNA-dependent protein kinase (PKR) and its phosphorylated substrate, eukaryotic initiation factor 2α (eIF2α) in postmortem AD brain tissues. The puntated staining has been considered to be a characteristic of GVD, where the accumulation of phosphorylated PKR and eIF2α is highly localized in GVD neurons. We are the first laboratory to report that activation of PKR in β-amyloid (Aβ) peptide-induced neuronal apoptosis. Since eIF2α kinases such as PKR have been shown to play significant roles in vacuoles formation, it is hypothesized that PKR is one of the key kinases leading to the formation of vacuoles in GVD in AD.Goal and specific aims: As long-term autophagy is detrimental to neurons, the goal of our study is to inhibit autophagic processes in GVD for AD patient by elucidating the roles of PKR in GVD or the formation of vacuoles in the autophagic processes. We have two specific aims to accomplish our goal: (1) To use molecular biology methods to show the significant roles of PKR in autophagic processes by using Aβ peptide as toxic agent. (2) To use live cell imaging method to further study the roles of PKR and the degradation of organelles by monitoring dynamic changes of organelles (ER and mitochondria), PKR (GFP-PKR) and markers for autophagy (mRFP-LC3) in the formation of vacuoles.

List of Research Outputs

Chang R.C.C., Yu M.S., Suen K.C., Lai S.W., Kwok N.S. and Hugon J., Differential signaling of unfolded protein responses (UPR) and endoplasmic reticulum (ER) stress in neurons exposed to b-amyloid peptide, Society for Neuroscience. 2004, Program No. 1000.22.

Chang R.C.C., Editorial Board member, American Journal of Alzheimer's Disease and Related Dementias. 2004.

Chang R.C.C., Molecular Signaling of Neuronal Death in Alzheimer's Disease. What have we learnt so far?, Deaprtment of Biochemistry, Hong Kong University of Science and Technology. 2005.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Fang X., Chang R.C.C., Yuen W.H. and Zee S.S.Y., Immune modulatory effects of Prunella vulgaris L., International Journal of Molecular Medicine. 2005, 15: 491-496.

Lafay C., Page G., Perault M.C., Chang R.C.C. and Hugon J., Ab modulates PKR, mTOR/4EBP1 and P70S6K signaling controls of translation in neural cells, Neurobiology of Aging. 2004, 25 supplement 2: S177 P1-288.

So K.F., Chan H.C., Chang R.C.C., Chan Y.M.S., Yuen W.H. and Zee S.S.Y., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceutical, Guangzhou, China. 2004, 15.

Yu M.S., Lai S.W., Lin K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Characterization of polysaccharides from the folowers of Nerium indicum and their neuroprotective effects, International Journal of Molecular Medicine. 2004, 14: 917-924.

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Protein kinases as technological platforms to screen neuroprotective agents from Chinese medicine, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 69 No.P-36.

Researcher : Chen B

List of Research Outputs

Chen B., Tay D.K.C., Yu E.H. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase in retinal ganglion cell layer of postnatal golden hamster depends on light stimulation, FENS Forum 2004. 2: Abstract No. A194.8.

Huang J., Zhang X., Chen B., Ng A.H.L., Tanner J.A., Tay D.K.C., So K.F., Rachel R.A., Copeland N.G. and Jenkins N.A., Cre-transgenic mouse line for conditional gene knockout in retinal rod bipolar cells , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2005, 46: 3111S.

So K.F., Chen B., Yu E.H. and Tay D.K.C., The effect of light stimulation or optic nerve transection on the expression of NADPH-d in a sub-population of amacrine cells, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 230 No.5348-B551.

Researcher : Chen B

List of Research Outputs

Researcher : Chen H

List of Research Outputs

Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Implications of sperm DNA damage in expression of RAD51 and P53 in zygotes and two-cell embryos sired by golden hamsters with major accessory sex glands removed, Biology of Reproduction. 2004, 253 no. 698.

Researcher : Cheung A

Project Title:	Chromosomal aberrations and telomere changes in human ovarian surface epithelial cells during cell immortalization - a FISH/SKY study
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To study chromosomal aberrations in human ovarian surface epithelial (HOSE) cells during the immortalization process, and to correlate them with changes in telomere sizes.

Project Title:	Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To obtain telomere length profiles for indivdual chromosomes and to characterize dynamic telomere shortening in pre-crisis cells; to determine if the chromosomes with shorter telomeres or faster telomere shortening are more frequently involved in the formation of chromosome aberrations during immortalization.

Project Title:	Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Allelic loss in esophageal precancerous and cancerous lesions: study of a high-risk population in China
Investigator(s):	Cheung A, Tsao GSW, Wang L.D.
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study and compare the LOH profiles in precancerous and cancerous esophageal lesions; to identify chromosomal regions with frequent allelic loss.

Project Title:	The role of Id-1 in esophageal carcinogenesis
Investigator(s):	Cheung A
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Centromeric instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

refer to hard copy proposal

List of Research Outputs

Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Implications of sperm DNA damage in expression of RAD51 and P53 in zygotes and two-cell embryos sired by golden hamsters with major accessory sex glands removed, Biology of Reproduction. 2004, 253 no. 698.

Cheung A., Editorial Board, In: Clive R Taylor, Jiang Gu, Applied Immunohistochemistry & Molecular Morphology. Lippincott Williams & Wilkins, 2005.

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Deng W., Tsao G.S.W., Guan X.Y., Lucas J.N., Si H., Leung C.S., Mak P., Wang L.D. and Cheung A., Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines, Oncogene. 2004, 23: 9090-9101.

Si H., Tsao G.S.W., Poon C.S.P. and Cheung A., Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma, Cancer Letters. 2004, 213: 231-239.

Si H., Tsao G.S.W., Poon C.S.P., Wong Y.C. and Cheung A., Physical status of HPV-16 in esophageal squamous cell carcinoma, Journal of Clinical Virology. 2005, 32: 19-23.

Tai L.S., Fang Y., Sham J.S.T., Deng W., Hu L., Xie D., Tsao G.S.W., Cheung A. and Guan X.Y., Establishment and characterization of a human non-small cell lung cancer cell line, Oncology Report. 2005, 13(6): 1029-1032.

Wong Y.C., Ling M.T., Wang X., Ouyang X.S., Cheung A. and Chan F.L., Id-1 protein is a new marker for PCA, In: J. J. Lee, S. A. Li, Antonio Llombart-Bosch, Hormonal Carcinogenesis IV. New York, Springer, 2005, IV: 197-208.

Researcher : Cheung ALM

Project Title:	Chromosomal aberrations and telomere changes in human ovarian surface epithelial cells during cell immortalization - a FISH/SKY study
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To study chromosomal aberrations in human ovarian surface epithelial (HOSE) cells during the immortalization process, and to correlate them with changes in telomere sizes.

Project Title:	Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

Project Title:	Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW, Guan XY
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Allelic loss in esophageal precancerous and cancerous lesions: study of a high-risk population in China
Investigator(s):	Cheung A, Tsao GSW, Wang L.D.
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study and compare the LOH profiles in precancerous and cancerous esophageal lesions; to identify chromosomal regions with frequent allelic loss.

Project Title:	The role of Id-1 in esophageal carcinogenesis
Investigator(s):	Cheung A
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Centromeric instability in human cells undergoing immortalization
Investigator(s):	Cheung A, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

refer to hard copy proposal

List of Research Outputs

Researcher : Cheung HW

List of Research Outputs

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Researcher : Cheung MPL

List of Research Outputs

Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Implications of sperm DNA damage in expression of RAD51 and P53 in zygotes and two-cell embryos sired by golden hamsters with major accessory sex glands removed, Biology of Reproduction. 2004, 253 no. 698.

Researcher : Cheung PPY

List of Research Outputs

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Researcher : Cheung ZHY

List of Research Outputs

He M., Cheung Z.H.Y., Yu E., Tay D.K.C. and So K.F., Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters, Neurochemical Research. 2004, 29 No. 11: 2153-2161.

Researcher : Chiu K

List of Research Outputs

Chiu K., Lam T.K., Li W.W.Y., Caprioli J. and Kwong J.M.K., Calpain and N-methyl-D-aspartate (NMDA)-induced ecxcitotoxicity in rat retinas, Brain Research. 2005, 1046: 207-215.

Researcher : Chua CW

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Researcher : Chua CW

List of Research Outputs

Researcher : Chung CM

List of Research Outputs

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Chung C.M., Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells. 2004, 85 pages.

Researcher : Chung CM

List of Research Outputs

Chung C.M., Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells. 2004, 85 pages.

Researcher : Chung SK

Project Title:	Role of endothelial and astrocytic ET-1 in the pathogenesis of diabetic retinopathy, a major cause of blindness in man
Investigator(s):	Chung SK, Lo ACY
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2000

Abstract:

To use astrocytes (GFAP-ET-1) mice and endothelial cell (Tie1-ET-1) mice to study the involvement of endothelin-1 (ET-1) in retinal structural lesions and barrier dysfunction in experimental diabetes.

Project Title:	Characterization of endothelin-1 gene manipulated mice for ischemic stroke, a leading cause of death and disability
Investigator(s):	Chung SK
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project attempts to determine if the ET-1 knockout mice have more severe ischemic brain injuries. The absolute and regional cerebral blood flow, neurological deficit, infarct volume and the detailed molecular signals will be determined.

Project Title:	Molecular mechanisms of dementia associated with aging-related diseases, alzheimer's and multi-infarct
Investigator(s):	Chung SK
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To characterize of GET, TET or ETKO mice with human Swedish mutation in APP gene; to determine amyloidogenesis and neuropathological features in ET-1/mutant APPYAC brain; to determine memory deficit and brain activity in ET-1/mutant APPYAC mice; to determine the role of infarct and mutant APP on oxidative stress and neuropathogical features; to determine efficacy of ECE inhibitor and ETA and ETB receptors antagonists for neurotoxicity.

Project Title:	Molecular mechanisms of dementia associated with aging-related diseases, alzheimer's and multi-infarct
Investigator(s):	Chung SK
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

Project Title:	Genetic approaches to understand the pathogenesis of diabetic neuropathy: common, debilitating disease
Investigator(s):	Chung SK
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To determine contributions of AR and SD to the increased oxidative stress in diabetic nervous tissues; to determine the relationship between AR activity and the activation of NF-[kappa]B and PKC; to determine the contributions of vascular and nervous tissues to the diabetes-induced MNCV deficit; to determine the role of AR in the pathogenesis of chronic neuropathy by using the Thy1-YFP transgenic mice.

Project Title:	Genetic approaches to understand the pathogenesis of diabetic neuropathy: common, debilitating disease
Investigator(s):	Chung SK
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Researcher : Deng W

List of Research Outputs

Deng W., Tsao G.S.W., Guan X.Y., Lucas J.N., Si H., Leung C.S., Mak P., Wang L.D. and Cheung A., Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines, Oncogene. 2004, 23: 9090-9101.

Deng W., Dynamics Of Chromosome Instability In Human Cells undergoing Immortalization, 2005.

Deng W., Dynamics of chromosome instability in human cells undergoing immortalization. 2005, 263 pages.

Feng H., Choy M.Y., Deng W., Wong H.L., Lau W.M., Cheung A.N.Y., Ngan H.Y.S. and Tsao G.S.W., Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1), Journal of The Society for Gynecologic Investigation. 2005, 12(4): e21-32.

Tai L.S., Fang Y., Sham J.S.T., Deng W., Hu L., Xie D., Tsao G.S.W., Cheung A. and Guan X.Y., Establishment and characterization of a human non-small cell lung cancer cell line, Oncology Report. 2005, 13(6): 1029-1032.

Researcher : Deng W

List of Research Outputs

Deng W., Dynamics Of Chromosome Instability In Human Cells undergoing Immortalization, 2005.

Deng W., Dynamics of chromosome instability in human cells undergoing immortalization. 2005, 263 pages.

Researcher : Ding Y

List of Research Outputs

Zeng Y.S., Ding Y., Wu L.Z., Guo J., Li B. and Wu W., Effects of Schwann cells on the survival and differentiation of neural stem cells transplanted into injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Researcher : Dominy NJ

List of Research Outputs

Dominy N.J., Lucas P.W., Wrangham R.W. and Ramsden L., The potential importance of fruit texture for the evolution of digital dexterity, Folia Primatologica. 2004, 75 supplement 1: 189 No. 328.

Researcher : Ellis-Behnke RG

List of Research Outputs

So K.F., Ellis-Behnke R.G., Zhang S., You S.W., Liang Y., Tay D.K.C., Semino C.E. and Schneider G.E., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, 中國組織工程、干細胞与神經再生學術會議綸文集. 2004, 6-9.

Researcher : Feng H

List of Research Outputs

Feng H., Choy M.Y., Deng W., Wong H.L., Lau W.M., Cheung A.N.Y., Ngan H.Y.S. and Tsao G.S.W., Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1), Journal of The Society for Gynecologic Investigation. 2005, 12(4): e21-32.

Feng H., Geng expression profile in human trophoblast and gestational trophoblastic disease. 2004, 211 pages.

Xue W., Chan Y.K., Feng H., Chiu P.M., Ngan H.Y.S., Tsao G.S.W. and Cheung A.N.Y., Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma, The Journal of Molecular Diagnostics. 2004, 6(4): 326-334.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Researcher : Feng H

List of Research Outputs

Feng H., Geng expression profile in human trophoblast and gestational trophoblastic disease. 2004, 211 pages.

Researcher : Fu Q

List of Research Outputs

Fu Q., Wu W., Mi S. and So K.F., LINGO-1 Exerts neuroprotection in a rat glaucoma model, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 7 No.157-B131.

Researcher : Fung KL

List of Research Outputs

Ling M.T., Fung K.L., Wang X. and Wong Y.C., Proteasome mediated degradation of Id-1 is associated with TNF-alpha induced apoptosis in prostate cancer cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 1267 No. 5365.

Researcher : Guo J

List of Research Outputs

Zeng Y.S., Ding Y., Wu L.Z., Guo J., Li B. and Wu W., Effects of Schwann cells on the survival and differentiation of neural stem cells transplanted into injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Researcher : He M

List of Research Outputs

He M., Cheung Z.H.Y., Yu E., Tay D.K.C. and So K.F., Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters, Neurochemical Research. 2004, 29 No. 11: 2153-2161.

Researcher : Hu B

List of Research Outputs

Li S., Hu B., Tay D.K.C., So K.F. and Yip H.K.F., Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats, Brain Research. 2004, 1029: 56-64.

Researcher : Hui CM

List of Research Outputs

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Hui C.M., Role of Id-1 in proliferation and survival of esophageal carcinoma cells. 2004, 98 pages.

Researcher : Hui CM

List of Research Outputs

Hui C.M., Role of Id-1 in proliferation and survival of esophageal carcinoma cells. 2004, 98 pages.

Researcher : Kwok NS

List of Research Outputs

Chang R.C.C., Yu M.S., Suen K.C., Lai S.W., Kwok N.S. and Hugon J., Differential signaling of unfolded protein responses (UPR) and endoplasmic reticulum (ER) stress in neurons exposed to b-amyloid peptide, Society for Neuroscience. 2004, Program No. 1000.22.

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Researcher : Kwok WK

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Kwok W.K., Wong Y.C. and Wang X., Upregulation of TWIST in prostate cancer and its implication as a therapeutic target, Proceedings of the American Association for Cancer Research, April 2005. 46: 1312 No. 5574.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Researcher : Kwok WK

List of Research Outputs

Researcher : Lai KW

List of Research Outputs

Lai K.W., An invitro study of ovarian folliculogenesis in galactosemic rats. 2004, 109 pages.

Lai K.W. and O W.S., In vitro folliculogenesis and aldose reductase protein expression in galactosemic rat model, Biology of Reproduction. 2004, 197-198 no. 459.

Researcher : Lai KW

List of Research Outputs

Lai K.W., An invitro study of ovarian folliculogenesis in galactosemic rats. 2004, 109 pages.

Lai K.W. and O W.S., In vitro folliculogenesis and aldose reductase protein expression in galactosemic rat model, Biology of Reproduction. 2004, 197-198 no. 459.

Researcher : Lai SW

List of Research Outputs

Chang R.C.C., Yu M.S., Suen K.C., Lai S.W., Kwok N.S. and Hugon J., Differential signaling of unfolded protein responses (UPR) and endoplasmic reticulum (ER) stress in neurons exposed to b-amyloid peptide, Society for Neuroscience. 2004, Program No. 1000.22.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Yu M.S., Lai S.W., Lin K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Characterization of polysaccharides from the folowers of Nerium indicum and their neuroprotective effects, International Journal of Molecular Medicine. 2004, 14: 917-924.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Protein kinases as technological platforms to screen neuroprotective agents from Chinese medicine, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 69 No.P-36.

Researcher : Lai SW

List of Research Outputs

Researcher : Lau TCM

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Researcher : Lau WM

List of Research Outputs

Feng H., Choy M.Y., Deng W., Wong H.L., Lau W.M., Cheung A.N.Y., Ngan H.Y.S. and Tsao G.S.W., Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1), Journal of The Society for Gynecologic Investigation. 2005, 12(4): e21-32.

Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Neuroscience Letters 370S. 2004, S11.

Lau W.M., Wong A.O.L., Tsao G.S.W., So K.F. and Yip H.K.F., Molecular cloning and expression of telomerase reverse transcriptase (TERT) in zebrafish central nervous system, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Yip H.K.F. and Lau W.M., Expression pattern of telomerase reverse transcriptase (TERT) in the developing mouse retina, Society for Neuroscience Annual Meeting. 2005.

Yip H.K.F., Lau W.M., Tsao G.S.W., So K.F. and Wong A.O.L., Zebrafish telomerase catalytic subunit: Molecular cloning and characterization of a ribonucleoprotein reverse transcriptase gene highly expressed in the retina, Association for Research in Vision and Ophthalmology Annual Meeting. 2005.

Researcher : Lau WM

List of Research Outputs

Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Neuroscience Letters 370S. 2004, S11.

Yip H.K.F. and Lau W.M., Expression pattern of telomerase reverse transcriptase (TERT) in the developing mouse retina, Society for Neuroscience Annual Meeting. 2005.

Researcher : Lee DTW

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Researcher : Lee VWH

List of Research Outputs

Mok K.H. and Lee V.W.H., Effect of optical zone ablation diameter on LASIK-induced higher order optical abefrations., Journal of Refractive Surgery. 2005, 21(2): 141-143.

Researcher : Leung KM

List of Research Outputs

Chen J.H., Tipoe G.L., Liong E.C., So H.S.H., Leung K.M., Tom W.M., Fung P.C.W. and Nanji A.A., Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants, American Journal of Clinical Nutrition. 2004, 80: 742-751.

Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Researcher : Leung TM

List of Research Outputs

Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Researcher : Li B

List of Research Outputs

Zeng Y.S., Ding Y., Wu L.Z., Guo J., Li B. and Wu W., Effects of Schwann cells on the survival and differentiation of neural stem cells transplanted into injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Researcher : Li HM

List of Research Outputs

Li H.M., Functional studies of epstein-barr latent membrane protein 1 in nasopharyngeal epithelial cells. 2004, 201 pages.

Researcher : Li S

List of Research Outputs

Li S., Hu B., Tay D.K.C., So K.F. and Yip H.K.F., Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats, Brain Research. 2004, 1029: 56-64.

Researcher : Li SY

List of Research Outputs

Li S.Y., Tay D.K.C., Chan H.H. and So K.F., Abnormalies of scotopic electroretinography in rats with laser-induced ocular hypertension, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 49 No. P-16.

Researcher : Liang Y

List of Research Outputs

So K.F., Ellis-Behnke R.G., Zhang S., You S.W., Liang Y., Tay D.K.C., Semino C.E. and Schneider G.E., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, 中國組織工程、干細胞与神經再生學術會議綸文集. 2004, 6-9.

Researcher : Liao S

List of Research Outputs

Liao S., Chow P.H. and O W.S., Leptin expression in embryos sired by male golden hamsters with all accessory sex glands removed, Symposium on "Post-meiotic Approaches to Male Contraception", The Chinese University of Hong Kong, June 8-10, 2005. 42 No. P5.

Researcher : Lin KF

List of Research Outputs

Lin K.F., Evaluation of calcium/calmodulin kinase II as therapeutic target in beta-amyloid peptide neurotoxicity. 2004, 110 pages.

Yu M.S., Lai S.W., Lin K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Characterization of polysaccharides from the folowers of Nerium indicum and their neuroprotective effects, International Journal of Molecular Medicine. 2004, 14: 917-924.

Researcher : Ling MT

List of Research Outputs

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Ling M.T., Fung K.L., Wang X. and Wong Y.C., Proteasome mediated degradation of Id-1 is associated with TNF-alpha induced apoptosis in prostate cancer cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 1267 No. 5365.

Wang X., Zhang X., Ling M.T. and Wong Y.C., Inactivation of Id-1 in prostate cancer cells: a potential therapeutic target in inducing chemosensitization, Proceedings of the American Association for Cancer Research, April 2005.. 2005, 46: 529 No. 2252.

Wong Y.C., Ling M.T., Wang X., Ouyang X.S., Cheung A. and Chan F.L., Id-1 protein is a new marker for PCA, In: J. J. Lee, S. A. Li, Antonio Llombart-Bosch, Hormonal Carcinogenesis IV. New York, Springer, 2005, IV: 197-208.

Wong Y.C., Wang X., Ling M.T., Ouyang X.S. and Chan F.L., Prostate Cancer: The Id1 Story, Acta Histochemica ET Cytochemica. 2005, 37(6): 331-337.

Yap Y.L., Zhang X., Ling M.T., Wang X., Wong Y.C. and Danchin A.L.M., Classification between normal and tumor tissues based on the pair-wise gene expression ratio, BMC Cancer . 2004, 4: 72.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Zhou C., Ling M.T., Lee T.K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen independent prostate cancer cells through inactivation of RhoA-GTPase, Proceedings of the American Association for Cancer Research, April 2005. 46: Abstract No. 669.

Researcher : Liong EC

List of Research Outputs

Lam S.S.Y., Liong E.C., Tipoe G.L. and Fung M.L., Expression of HIF-2a and HIF-3a in the rat carotid body in chronic hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan. 2005, P4: p60.

Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Hypoxia-inducible factor (HIF)-1a and endothelin-1 expression in the rat carotid body during intermittent hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan, P3, p.59. 2005.

Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Increased expression of angiotensin II receptor and oxidative stress in the rat carotid body during intermittent hypoxia, Taiwan-Hong Kong International Symposium on Neural Physiology, Tainan, Taiwan. 2004.

Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Intermittent hypoxia increases AT1 receptor and oxidative stress in the rat carotid body, 6th World Congress on Mountain Medicine & High Altitude Physiology, 2004, Xining, Qinghai, China. (High Altitude Medicine & Biology . 2004, 5(2): 238.

Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Protein expression of HIF-1a and endothelin-1 in the rat carotid body in chronic and intermittent hypoxia. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P17, 2004. Journal of the Hong Kong College of Cardiology 12(3/4). 2004, 103.

Lau T.H.Y., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M., Nanji A.A. and Tipoe G.L., Hepatic vascular vasodilatory response to chronic hypoxia via nitric oxide. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P16, 2004. (Journal of the Hong Kong College of Cardiology, 12(3/4):103. 2004.

Lau T.H.Y., Tipoe G.L., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors and hypoxia-inducible genes mediate the hepatic vascular adaptive response to chronic hypoxia, Pathological Society of Great Britain and Ireland, Meeting Journal of Pathology, Suppl.. 2005, 205: 11-11.

Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Leung T.M., Tipoe G.L., Lau T.H.Y., Liong E.C., So H., Leung K.M., Leung W.M., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model, Society of Pathology Meeting, 2005 Journal of Pathology, Suppl. . 2005, 205: 11-11.

Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich, P15. 2004.

Tipoe G.L., Lau T.Y.H., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors mediate hepatic vascular adaptive responses in chronic hypoxia, 55th Annual Meeting of AASLD, Boston . 2004.

Researcher : Lucas PW

Project Title:	Incisal action and deformation transitions in foods
Investigator(s):	Lucas PW
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To measure incisal efficiency in individuals and to establish the anatomical and physiological variables that affect this.

Project Title:	The mechanics of the first bite
Investigator(s):	Lucas PW
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004
Completion Date:	12/2004

Abstract:

Refer to hard copy

List of Research Outputs

Dominy N.J., Lucas P.W., Wrangham R.W. and Ramsden L., The potential importance of fruit texture for the evolution of digital dexterity, Folia Primatologica. 2004, 75 supplement 1: 189 No. 328.

Riba-Hernandez P., Stoner K.E. and Lucas P.W., The importance of trichromacy for detecting monosaccharide-rich fruits in spider monkeys, Folia Primatologica. 2004, 75 supplement 1: 188 No. 327.

Stoner K.E., Riba-Hernandez P. and Lucas P.W., Comparative use of colour vision for frugivory by sympatric species of platyrrhines, Folia Primatologica. 2004, 75 supplement 1: 187-188 No. 326.

Researcher : Man WYC

List of Research Outputs

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Researcher : Mok KH

List of Research Outputs

Mok K.H. and Lee V.W.H., Effect of optical zone ablation diameter on LASIK-induced higher order optical abefrations., Journal of Refractive Surgery. 2005, 21(2): 141-143.

Mok K.H., The Charactterization of retinal nerve fibre layer thickness in normal, high-tension and normal-tension glacuma using optical coherence tomography . 2005, 116 pages.

Researcher : Mok KH

List of Research Outputs

Mok K.H. and Lee V.W.H., Effect of optical zone ablation diameter on LASIK-induced higher order optical abefrations., Journal of Refractive Surgery. 2005, 21(2): 141-143.

Mok K.H., The Charactterization of retinal nerve fibre layer thickness in normal, high-tension and normal-tension glacuma using optical coherence tomography . 2005, 116 pages.

Researcher : O WS

Project Title:	A novel function the male accessory sex gland secretions on male germ cell development in the testis
Investigator(s):	O WS
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To find out (1) how the removal of male accessory sex glands can affect the male germ cell development in terms of p53 conformation from "wild type" to "mutation" form; (2) to measure the plasma Zn⁺⁺ levels in plasma; (3) to co-localise by immuno-histochemical and histochemical methods the repair enzyme, RAD51 and Zn⁺⁺ in the male germ cells in the testis.

Project Title:	Effect of male accessory sex gland secretion on leptin expression - from fertilization to mid gestation
Investigator(s):	O WS
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Implications of sperm DNA damage in expression of RAD51 and P53 in zygotes and two-cell embryos sired by golden hamsters with major accessory sex glands removed, Biology of Reproduction. 2004, 253 no. 698.

Ho W.K., O W.S. and Chow P.H., Absence of ventral prostate gland secretion in the ejaculate alters the profile of proteins in preimplantation uterine fluid - a study in the golden hamster, Reproductive BioMedicine Online. 2004, 7 Supplement 1: 17 no. O-44.

Lai K.W. and O W.S., In vitro folliculogenesis and aldose reductase protein expression in galactosemic rat model, Biology of Reproduction. 2004, 197-198 no. 459.

Liao S., Chow P.H. and O W.S., Leptin expression in embryos sired by male golden hamsters with all accessory sex glands removed, Symposium on "Post-meiotic Approaches to Male Contraception", The Chinese University of Hong Kong, June 8-10, 2005. 42 No. P5.

O W.S. and Chow P.H., Male genital tract antioxidant enzymes - their ability to preserve sperm DNA integrity, Symposium on "Post-meiotic Approaches to Male Contraception", The Chinese University of Hong Kong, June 8-10, 2005. 17.

Poon H.K., O W.S., Ferguson-Smith A. and Chow P.H., Absence of accessory sex gland secretion perturbs the active DNA demethylation of sperm genome in vivo in fertilized oocytes of mouse and golden hamster, Symposium on "Post-meiotic Approaches to Male Contraception", The Chinese University of Hong Kong, June 8-10, 2005. 43 No. P6.

Researcher : Schneider GE

List of Research Outputs

So K.F., Ellis-Behnke R.G., Zhang S., You S.W., Liang Y., Tay D.K.C., Semino C.E. and Schneider G.E., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, 中國組織工程、干細胞与神經再生學術會議綸文集. 2004, 6-9.

Researcher : Si H

List of Research Outputs

Deng W., Tsao G.S.W., Guan X.Y., Lucas J.N., Si H., Leung C.S., Mak P., Wang L.D. and Cheung A., Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines, Oncogene. 2004, 23: 9090-9101.

Si H., Tsao G.S.W., Poon C.S.P. and Cheung A., Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma, Cancer Letters. 2004, 213: 231-239.

Si H., Tsao G.S.W., Poon C.S.P., Wong Y.C. and Cheung A., Physical status of HPV-16 in esophageal squamous cell carcinoma, Journal of Clinical Virology. 2005, 32: 19-23.

Researcher : Si H

List of Research Outputs

Si H., Tsao G.S.W., Poon C.S.P. and Cheung A., Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma, Cancer Letters. 2004, 213: 231-239.

Si H., Tsao G.S.W., Poon C.S.P., Wong Y.C. and Cheung A., Physical status of HPV-16 in esophageal squamous cell carcinoma, Journal of Clinical Virology. 2005, 32: 19-23.

Researcher : So KF

Project Title:	Molecular signaling of PKR/EiF2-[alpha] and GSK3[beta] in the pathophysiology of glaucoma
Investigator(s):	So KF, Hugon J, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To further explore the roles of PKR-eIF2[alpha] in neuronal apoptosis of RGCs in experimental glaucoma; to study whether inhibition of PKR-eIF2[alpha] and GSK3[beta] pathways affords neuroprotection of RGCs; to investigate how the influence of GSK3[beta] on PKR-eIF2[alpha] pathways in the loss of RGCs.

Project Title:	The involvement of P13k/Akt pathway in the regulation of the caspases activity of axotomized retinal ganglion cells
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	12/2004

Abstract:

To elucidate the molecular events contribution to the late onset of detectable axotomized RGC death by examining the kinetics of caspase activation, and the mechanisms implicated in the regulation of caspase activation.

Project Title:	Neuroprotection in steroid therapy: an animal model
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	The effect of CNTF and BDNF on retinal ganglion cell survival and nitric oxide expression after optic nerve injury
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To investigate the importance of different types of neurotrophic factors on the survival of retinal ganglion cells and their relationship to the expression of nitric oxide.

List of Research Outputs

Chan H.H.L., Leung M.C.P. and So K.F., Electroacupuncture provides a new approach to neuroprotection in rats with induced-glaucoma, J Alternative and Complementary Medicine. 2005, 11 (2): 315-322.

Chan Y.F., Wu W., McCoy J., Pepinsky B., Sha M. and So K.F., LINGO-1 rescues retinal ganglion cells after optic nerve transaction, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 749.5.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Chen B., Tay D.K.C., Yu E.H. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase in retinal ganglion cell layer of postnatal golden hamster depends on light stimulation, FENS Forum 2004. 2: Abstract No. A194.8.

Cheung S.F., Lam K.S.L., So K.F., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing endothelin-1 in endothelial cells have blood-retinal barrier breakdown and lower expression of glial fibrillary acidic protein (Poster presentation), The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, Jan 13-14. 2005, 37 No. P-4.

Cui Q. and So K.F., Involvement of cAMP in neuronal survival and axonal regeneration, Anatomical Science International . Japan, Blackwell Publishing, 2004, 79(4): 209-212.

Fu Q., Wu W., Mi S. and So K.F., LINGO-1 Exerts neuroprotection in a rat glaucoma model, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 7 No.157-B131.

He M., Cheung Z.H.Y., Yu E., Tay D.K.C. and So K.F., Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters, Neurochemical Research. 2004, 29 No. 11: 2153-2161.

Huang J., Zhang X., Chen B., Ng A.H.L., Tanner J.A., Tay D.K.C., So K.F., Rachel R.A., Copeland N.G. and Jenkins N.A., Cre-transgenic mouse line for conditional gene knockout in retinal rod bipolar cells , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2005, 46: 3111S.

Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Neuroscience Letters 370S. 2004, S11.

Lau W.M., Wong A.O.L., Tsao G.S.W., So K.F. and Yip H.K.F., Molecular cloning and expression of telomerase reverse transcriptase (TERT) in zebrafish central nervous system, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Li R.S., Tay D.K.C., Chan H.H. and So K.F., Changes of retinal function after the induction of ocular hypertension in rats, XVI International Congress of Eye Research, Sydney, Australia, August 29 - September 3, 2004. PGL13.

Li S., Hu B., Tay D.K.C., So K.F. and Yip H.K.F., Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats, Brain Research. 2004, 1029: 56-64.

Li S.Y., Tay D.K.C., Chan H.H. and So K.F., Abnormalies of scotopic electroretinography in rats with laser-induced ocular hypertension, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 49 No. P-16.

So K.F., Axonal Regeneration in the CNS, 24th Annual Scientific Meeting of Hong Kong Society of Neurosciences. Hong Kong SAR, China, 2005, 17 No. PL-1.

So K.F., China Spinal Cord Injury Network, The 4th Asia Pacific Symposium on Neuroregeneration. Osaka, Japan, 2004.

So K.F., Yick L.W., Cheung P.T. and Wu W., Combining lithium chloride and chondroitinase ABC to enhance the regeneration of rubrospinal neurons after spinal cord injury, 9th International Conference on Neural Transplantation and Repair, Taiwan. Taiwan, 2005, 9 No.S2-2.

So K.F., Editorial Board, Member, Molecular and Genetic Medicine. Oxford, UK, Library Publishing Media, 2005.

So K.F., Editorial Board, Member, Neuroscience Bulletin. Beijing, China, Science Press, 2005.

So K.F., Inaugural International Congress on Complementary and Alternative Medicines (ICCAM) 2005, Singapore. 2005, 91.

So K.F., Chan H.C., Chang R.C.C., Chan Y.M.S., Yuen W.H. and Zee S.S.Y., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceutical, Guangzhou, China. 2004, 15.

So K.F., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceuticals. 2004.

So K.F., Neuroprotection and signaling pathways in a rat glaucoma model, 16th International Congres of the IFAA (Int’l Fed. Asso. Anatomistis). Kyoto, Japan, 2004.

So K.F., Neuroprotection and signaling pathways in a rat glaucoma model, Proceedings, Anatomical Science International. 2004, 79 Supplement: S12-1.

So K.F., Neuroprotective effect of Chinese Herbal extracts, Proceeding, Medicine in the 21st century, Tri-Conference & Bio-Forum, Shanghai, China, July 24-27, 2004. T2-A2.1: 76.

So K.F., Neuroprotective effect of Chinese herbal extracts, Medicine in the 21st Century, Tri-Conference & Bio-Forum. Shanghai, China, 2004.

So K.F., Neuroprotective effects of Lycium barbarum Lynn in protecting retinal ganglion cells in an ocular hypertension model of glaucoma, Inaugural, International Congress on Complementary and Alternative Medicines (ICCAM) 2005. 2005.

So K.F., Optic nerve regeneration in adult mammals, The Inaugural Pacific Rim Brain Conference. Hawaii, USA, 2004.

So K.F., Optic nerve regeneration in adult mammals, The Inaugural Pacific Rim Brain Conference, Hawaii, August 2-4, 2004. Session 1.3.

So K.F., Preservation of synaptic connection as an example of neuronal protection in injuries to the visual system, Conference on Stroke Rehabilitation. Hong Kong SAR, China, 2005.

So K.F., Regeneration strategies to promote repair of the injured optic nerve in adult mammals, The 7th China-Japan Joint Seminar on Histochemistry and Cytochemistry. Wuhan, China, 2004.

So K.F., Regeneration strategies to promote repair of the injured optic nerve in adult mammals, The 7th China-Japan Joint Seminar on Histochemistry and Cytochemistry and The 4th International Conference of China on Anatomical Sciences, China. 2004, 13(3): 327-328.

So K.F., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, National Conference on Tissue Engineering, Stem Cells & Neuroregeneration. Nantong, China, 2004.

So K.F., Ellis-Behnke R.G., Zhang S., You S.W., Liang Y., Tay D.K.C., Semino C.E. and Schneider G.E., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, 中國組織工程、干細胞与神經再生學術會議綸文集. 2004, 6-9.

So K.F., Strategies to promote optic nerve regeneration, II International Congress on Neuroregeneration. Rio de Janeiro, Brazil, 2004.

So K.F., Strategies to promote optic nerve regeneration, II International Congress on Neuroregeneration, Brazil, September 20-24, 2004. 20 Abstract no. NE0035.

So K.F., Strategies to promote optic nerve regeneration, XVI International Congress of Eye Research (ICER). Sydney, Australia, 2004.

So K.F., Strategies to promote optic nerve regeneration, XVI International Congress of Eye Research, Sydney, Australia, August 29 - Sept. 3, 2004. 134.

So K.F., Chen B., Yu E.H. and Tay D.K.C., The effect of light stimulation or optic nerve transection on the expression of NADPH-d in a sub-population of amacrine cells, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 230 No.5348-B551.

So K.F., You S.W. and Cui Q., Transplantation of peripheral nerve tissues to enhance optic nerve regeneration in adult mammals, In: CAI Nan-Shan(ed.), Fudan Lectures in Neurobiology. School of Life Sciences, Fudan University, Shanghai, 2004, XX: 97-107.

Yick L.W., So K.F., McCoy J., Pepinsky B., Mi S. and Wu W., LINGO-1 promotes axonal regeneration and functional recovery after spinal cord injury, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 185.3.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons afte spinal cord injury, Neuroscience Letters. 2004, 370 supplement: S38.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons after spinal cord injury, Symposium on "neural plasticity, development and repair", Hong Kong, 2004.

Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury, Journal of Neurotrauma. 2004, 21 no. 7: 932-943.

Yip H.K.F., Lau W.M., Tsao G.S.W., So K.F. and Wong A.O.L., Zebrafish telomerase catalytic subunit: Molecular cloning and characterization of a ribonucleoprotein reverse transcriptase gene highly expressed in the retina, Association for Research in Vision and Ophthalmology Annual Meeting. 2005.

Young W. and So K.F., The China spinal cord injury network, 4th Asia Pacific symposium on Neural Regeneration, Japan. 2004, 30 No. L23.

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Protein kinases as technological platforms to screen neuroprotective agents from Chinese medicine, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 69 No.P-36.

Yuan Q., So K.F. and Wu W., Age-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomy, Neuroscience Letters. 2004, 370 Supplement: S11.

Yuan Q.J., So K.F. and Wu W., Neuronal and glial reactiions following hypophysectiomy in developing and adult rats, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 758.14.

Zhang C.W., Lu Q., You S., Zbi Y., Yip H.K.F., Wu W., So K.F. and Cui Q., CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury, Investigative Ophthalmology and Visual Science. 2005, 46 No. 4: 1497-1503.

Zhi Y., Lu Q., Zhang C.W., Yip H.K.F., So K.F. and Cui Q., Different optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophoc factor but not neurotrophin-4/5, Brain Research. 2005, 1047: 224-232.

Researcher : Suen KC

List of Research Outputs

Chang R.C.C., Yu M.S., Suen K.C., Lai S.W., Kwok N.S. and Hugon J., Differential signaling of unfolded protein responses (UPR) and endoplasmic reticulum (ER) stress in neurons exposed to b-amyloid peptide, Society for Neuroscience. 2004, Program No. 1000.22.

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Researcher : Suen KC

List of Research Outputs

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Researcher : Tay DKC

Project Title:	Neurotrophic factors affect axonal regeneration of injured retinocollicular projections in hamsters
Investigator(s):	Tay DKC, Yip HKF, Tan MML, So KF
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001

Abstract:

To examine the effect of neurotrophic factors on retinal ganglion cell (RGC) axon regrowth and target re-innervation after distal axotomy in the adult central nervous system (CNS); to determine the efficacy of SC brachial transection in adult hamsters and the relative important of collateral connections on the survival of RGCs following brachial transection; to determine the effect of perineuronal neurotropic factor application on retinocollicular axon regrowth and the target SC re-innervation after brachial lesions; to determine the combined effect of perineuronal neurotropic factor application and denaturation of putative inhibitory molecules on the extent of post-lesion retinocollicular axon growth and target SC re-innervation; to determine whether target SC re-innervation is associated with re-expression of axon-target guidance molecules; to determine whether re-innervation of the target SC can be related to behavioural recovery.

Project Title:	The role of NADPH-d in the amacrine cells of early postnatal and adult hamsters
Investigator(s):	Tay DKC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To test the hypothesis that NADPH-d is necessary to mediate visual signals in hamsters and to further investigate the role of NADPH-d in maintaining visual function in adult hamsters.

List of Research Outputs

Chen B., Tay D.K.C., Yu E.H. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase in retinal ganglion cell layer of postnatal golden hamster depends on light stimulation, FENS Forum 2004. 2: Abstract No. A194.8.

He M., Cheung Z.H.Y., Yu E., Tay D.K.C. and So K.F., Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters, Neurochemical Research. 2004, 29 No. 11: 2153-2161.

Huang J., Zhang X., Chen B., Ng A.H.L., Tanner J.A., Tay D.K.C., So K.F., Rachel R.A., Copeland N.G. and Jenkins N.A., Cre-transgenic mouse line for conditional gene knockout in retinal rod bipolar cells , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2005, 46: 3111S.

Li R.S., Tay D.K.C., Chan H.H. and So K.F., Changes of retinal function after the induction of ocular hypertension in rats, XVI International Congress of Eye Research, Sydney, Australia, August 29 - September 3, 2004. PGL13.

Li S., Hu B., Tay D.K.C., So K.F. and Yip H.K.F., Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats, Brain Research. 2004, 1029: 56-64.

Li S.Y., Tay D.K.C., Chan H.H. and So K.F., Abnormalies of scotopic electroretinography in rats with laser-induced ocular hypertension, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 49 No. P-16.

So K.F., Ellis-Behnke R.G., Zhang S., You S.W., Liang Y., Tay D.K.C., Semino C.E. and Schneider G.E., Self assembling peptide nano-fibre hydrogel scaffold for brain lesion repair: In-vivo experiment on damaged brain, 中國組織工程、干細胞与神經再生學術會議綸文集. 2004, 6-9.

So K.F., Chen B., Yu E.H. and Tay D.K.C., The effect of light stimulation or optic nerve transection on the expression of NADPH-d in a sub-population of amacrine cells, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 230 No.5348-B551.

Researcher : Tipoe GL

Project Title:	The role of nitric oxide in acute and chronic liver injury
Investigator(s):	Tipoe GL, Fung ML
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To establish the underlying role of NO in acute and chronic liver injury.

Project Title:	The functional role of hypoxic inducible factor (HIF)-1 α in chronic liver hypoxia
Investigator(s):	Tipoe GL, Fung ML
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To evaluate whether necroinflammatory changes and oxidative stress exist in chronic liver hypoxia; to determine the hepatic expression of HIF-1α; to assess the expression of downstream genes which carry HRE and regulate vascular and metabolic responses such as iNOS, VEGF, eNOS, ET-1 and glucose transporters (Glut-1, 2 and 3) respectively; to determine the role of other nuclear transcription factors such as nuclear factor κ B (NF-κB) and activator protein -1 (AP-1) in chronic liver hypoxia.

Project Title:	Does nitric oxide modulate the development of liver fibrosis?
Investigator(s):	Tipoe GL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To determine the level of oxidative stress in our experimental model; to determine the expression of NO through its enzyme activity such as inducible NO synthase (iNOS) and eNOS mRNAs; to quantify the amount of fibrotic formation; to determine the activity of α-SMA, MMPs TIMPs and TGF-β1; to determine the levels of transcriptional factors such as NF-kappaB and AP-1.

List of Research Outputs

Chen J.H., Tipoe G.L., Liong E.C., So H.S.H., Leung K.M., Tom W.M., Fung P.C.W. and Nanji A.A., Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants, American Journal of Clinical Nutrition. 2004, 80: 742-751.

Chen Y., Tjong Y.W., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin enhances the hypoxic response of rat carotid body chemoreceptor, Journal of Pineal Research. 2005, 38: 157-163.

Guo X., Irwin M.G., Chan D., Tipoe G.L. and Cheung K.M.C., Differential fuctions of cyclooxygenase 1 and 2 in bone repair, European Cells and Materials. 2005, 10 Suppl. 3: 56.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Lam S.S.Y., Liong E.C., Tipoe G.L. and Fung M.L., Expression of HIF-2a and HIF-3a in the rat carotid body in chronic hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan. 2005, P4: p60.

Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Hypoxia-inducible factor (HIF)-1a and endothelin-1 expression in the rat carotid body during intermittent hypoxia, The 16th International Society for Arterial Chemoreception Meeting, Sendai, Japan, P3, p.59. 2005.

Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Increased expression of angiotensin II receptor and oxidative stress in the rat carotid body during intermittent hypoxia, Taiwan-Hong Kong International Symposium on Neural Physiology, Tainan, Taiwan. 2004.

Lam S.S.Y., Tipoe G.L., Tjong Y.W., Liong E.C. and Fung M.L., Intermittent hypoxia increases AT1 receptor and oxidative stress in the rat carotid body, 6th World Congress on Mountain Medicine & High Altitude Physiology, 2004, Xining, Qinghai, China. (High Altitude Medicine & Biology . 2004, 5(2): 238.

Lam S.S.Y., Tipoe G.L., Liong E.C. and Fung M.L., Protein expression of HIF-1a and endothelin-1 in the rat carotid body in chronic and intermittent hypoxia. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P17, 2004. Journal of the Hong Kong College of Cardiology 12(3/4). 2004, 103.

Lau T.H.Y., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M., Nanji A.A. and Tipoe G.L., Hepatic vascular vasodilatory response to chronic hypoxia via nitric oxide. The 8th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P16, 2004. (Journal of the Hong Kong College of Cardiology, 12(3/4):103. 2004.

Lau T.H.Y., Fung M.L., Tom W.M., Nanji A.A. and Tipoe G.L., Mediation of glucose transporters in hepatic adaptation to chronic hypoxia via hypoxia inducible factor, 9th Research Postgraduate Symposium, HKU. 2004.

Lau T.H.Y., Tipoe G.L., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors and hypoxia-inducible genes mediate the hepatic vascular adaptive response to chronic hypoxia, Pathological Society of Great Britain and Ireland, Meeting Journal of Pathology, Suppl.. 2005, 205: 11-11.

Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Leung T.M., Tipoe G.L., Lau T.H.Y., Liong E.C., So H., Leung K.M., Leung W.M., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model, Society of Pathology Meeting, 2005 Journal of Pathology, Suppl. . 2005, 205: 11-11.

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent contractions occur in arteries of wild type and COX2-/- but not in those of COX1-/- knockout mice, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 94, No. 4.31.

Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., The calcium ionophore A23187 causes endothelium-dependent contractions in the aorta of wild type but not COX1 knock-out male mice, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 33.

Tipoe G.L., Lau T.Y.H., Fung M.L., Liong E.C., So H., Liao L.C., Leung K.M. and Nanji A.A., Nuclear transcriptional factors mediate hepatic vascular adaptive responses in chronic hypoxia, 55th Annual Meeting of AASLD, Boston . 2004.

Tipoe G.L., Workshop on molecular and cell biology for clinicians , 9th Congress of the Asian Pacific Society of Respirology, Hong Kong. 2004.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Ho J.C., Mak J.C.W., Tipoe G.L., Ko C., Yan C. and Lam W.K., Inhaled fluticasone in bronchiectasis: a 12 month study, Thorax. 2005, 60: 239-243.

Researcher : Tsao GSW

Project Title:	Functional studies of the prevalent LMP1 variant associated with nasopharyngeal carcinoma of Hong Kong
Investigator(s):	Tsao GSW, Huang D.W.S.P., Young L.S.
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project attempts to examine:- i) the functional difference between the prevalent LMP1 variants isolated from NPC patients and healthy subjects; ii) the functional significance of the unique substitution of codon 335 in the prevalent LMP1 isolated from NPC patients in Hong Kong; and iii) if the transmission domain of the HK-LMP1 variants may have different ability in cell signaling.

Project Title:	Malignant transformation of normal esophageal epithelial cells by defined genetic elements
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To define the genetic alterations required for malignant transformation of human esophageal epithelial cells.

Project Title:	Functional analysis of expression of EBV encoded RNAs (EBERs) in nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Chang RCC, Huang D.W.S.P.
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To determine if expression of high level of EBER would alter the growth properties of nasopharyngeal epithelial cells; to examine alterations of gene expression profile in nasopharyngeal epithelial cells after expression of EBER; to examine if EBER expression may enhance the transformation properties of the EBV encoded oncogene-LMP1 in nasopharyngeal epithelial cells; to examine if EBER expression may induced resistance to TNFa induced apoptosis in nasopharyngeal epithelial cells.

Project Title:	Functional analysis of expression of EBV encoded RNAs (EBERs) in nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Chang RCC, Huang D.W.S.P.
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Mechanism of induction of Id1 expression by the EBV encoded LMP1 in nasopharyngeal epithelia cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To examine the cell signalling mechanism involved in the induction of ID1 expression by LMP1 and its functional significance.

Project Title:	Defining the genetic elements involved in immortalization and malignant transformation of primary nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Jin Y, Huang Poon D.W.S., Lo K.W.
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To examine the roles of inactivation of the P16 and RASSFIA genes, overexpression of deltaNp63 and telomerase reconstitution in the immortatlization of primary nasopharyngeal epithelial cells; to establish an immortalized nasopharyngeal epithelial cells using defined genetic elements for NPC oncogenesis study; to examine the susceptibility of immortalized nasopharyngeal cells to the malignant transformation by EBV latent genes/EBV infection.

Project Title:	Mapping and identification of gene(s) on chromosome 20q involved in cell immortalization
Investigator(s):	Tsao GSW, Cheung A, Kwong YL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2006

Abstract:

To map and define the regions of amplification on chromosome 20q in immortalized cells; to identify the gene on chromosome 20q overexpressed in immortalized cells; to carry our functional analysis of the overexpressed genes on chromosome 20q in normal epithelial cells before immortalization.

Project Title:	Functional study of EBV infection and genetic alterations in immortalized epithelial cells
Investigator(s):	Tsao GSW, Cao Y., Chen H, Tao YG, Tan YN, Li L.L.
Department:	Anatomy
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2004

Abstract:

To study intracellular signaling events regulating latent infection of EBV infection in nasopharyngeal epithelial cells; to study the role of the EBV encoded LMP1 in the immortalization and transformaton of premalignant nasopharyngeal epithelial cells.

Project Title:	Defining the genetic elements involved in immortalization and malignant transformation of primary nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Ault K., Neff T., Kelly K., Yeung W.S.B., Tsao G.S.W. and Lee C.K.F., Chemokine and cytokine gene expression in immortalized human oviduct epithelial cell infected with Chlamydia trachomatis, Chlamydia Basic Research Society 2005 Biennial Meeting, April 23-25, 2005, Indianapolis, USA. 2005.

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Deng W., Tsao G.S.W., Guan X.Y., Lucas J.N., Si H., Leung C.S., Mak P., Wang L.D. and Cheung A., Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines, Oncogene. 2004, 23: 9090-9101.

Fatima S., Hui K.S., Wong M.M., Tang W.K., Chui C.H., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Srivastava G., Ho K.P. and Tang J.C.O., Study of transforming capacity of two novel genes JS-1 and JS-2 in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma, 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, USA, 16-20 April. 2005.

Feng H., Choy M.Y., Deng W., Wong H.L., Lau W.M., Cheung A.N.Y., Ngan H.Y.S. and Tsao G.S.W., Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1), Journal of The Society for Gynecologic Investigation. 2005, 12(4): e21-32.

Fong P.Y., Xue W., Ngan H.Y.S., Chan Y.K., Khoo U.S., Tsao G.S.W., Chiu P.M., Man M.L.S. and Cheung A.N.Y., Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome, Cancer. 2004, 103(2): 268-276.

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HÖglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Hung H.L., Bangarusamy D.K., Xie D., Cheung A.K.L., Cheng Y., Kumaran M.K., Millar L., Liu E.T.B., Guan X.Y., Sham J.S.T., Fang Y., Li L., Wang N., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma, Oncogene. 2005, 24: 6525-6532.

Jin Y., Jin C., Lu M., Tsao G.S.W., Zhu J., Wennerberg J., Mertens F. and Kwong Y.L., Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas , Cancer Genetics and Cytogenetics . 2005, 156(1): 1-7.

Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Neuroscience Letters 370S. 2004, S11.

Lau W.M., Wong A.O.L., Tsao G.S.W., So K.F. and Yip H.K.F., Molecular cloning and expression of telomerase reverse transcriptase (TERT) in zebrafish central nervous system, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Qin Y., Wang L., Kwong D.L.W., Guan X.Y., Zhuang Z., Fan Z., An J. and Tsao G.S.W., Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Zhonghua Yi Xue Yi Chuan Xue Za Zhi. Linzhou Henan, 2004, 21(6): 625-8.

Si H., Tsao G.S.W., Poon C.S.P. and Cheung A., Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma, Cancer Letters. 2004, 213: 231-239.

Si H., Tsao G.S.W., Poon C.S.P., Wong Y.C. and Cheung A., Physical status of HPV-16 in esophageal squamous cell carcinoma, Journal of Clinical Virology. 2005, 32: 19-23.

Tai L.S., Fang Y., Sham J.S.T., Deng W., Hu L., Xie D., Tsao G.S.W., Cheung A. and Guan X.Y., Establishment and characterization of a human non-small cell lung cancer cell line, Oncology Report. 2005, 13(6): 1029-1032.

Takada T., Yagi Y., Maekita T., Imura M., Nakagawa S., Tsao G.S.W., Miyamoto K., Yoshino O., Yasugi T., Taketani Y. and Ushijima T., Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers, Cancer Science. 2004, 95 no.9: 741-744.

Wang L.D., Qin Y., Fan Z., Kwong D.L.W., He X., Chang Z.W., Li J.L., Guan X.Y., Tsao G.S.W., Sham J.S.T., Zheng S., Yang C.S. and Li J., Gain of 6p, 20p and loss of 10p, 10q in esophageal squamoud cell carcinoma are associated with lymph node metastasis, Proceedings of the American Association for Cancer Research. 2004, 45: 744 No. 3214.

Xue W., Chan Y.K., Feng H., Chiu P.M., Ngan H.Y.S., Tsao G.S.W. and Cheung A.N.Y., Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma, The Journal of Molecular Diagnostics. 2004, 6(4): 326-334.

Yip H.K.F., Lau W.M., Tsao G.S.W., So K.F. and Wong A.O.L., Zebrafish telomerase catalytic subunit: Molecular cloning and characterization of a ribonucleoprotein reverse transcriptase gene highly expressed in the retina, Association for Research in Vision and Ophthalmology Annual Meeting. 2005.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Wang Q

List of Research Outputs

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Researcher : Wang X

Project Title:	Downregulation of MAD2 expression and its significance in chemodrug sensitization in nasopharyngeal carcinoma cells
Investigator(s):	Wang X, Nicholls JM, Tsao GSW, Jin D
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To confirm that MAD2 expression is downregulated in clinical samples of NPC; to determine the mechanism by which MAD2 is downregulated in NPC; to establish whether upregulation of MAD2 expression can sensitize NPC cells to chemotherapy.

Project Title:	Downregulation of MAD2 expression and its significance in chemodrug sensitization in nasopharyngeal carcinoma cells
Investigator(s):	Wang X, Nicholls JM, Tsao GSW, Jin D
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors
Investigator(s):	Wang X, Jin D
Department:	Anatomy
Source(s) of Funding:	Lance Armstrong Foundation - General Award
Start Date:	10/2003

Abstract:

To investigate the association between decreased MAD2 protein expression and cisplatin resistance in TGCT cells; to study if exogenous expression of the MAD2 gene in TGCT cells can lead to chemosensitization to cisplatin in TGCT cells; to demonstrate that downregulation of MAD2 results in resistance ot cisplatin in TGCT cells; to characterize the role of MAD2 in cisplatin-induced cell death inTGCT cells; to identify binding partners of MAD2 in response to cisplatin-induced DNA damage.

Project Title:	The role of Id-1 in chemodrug resistance in nasopharyngeal carcinoma cells
Investigator(s):	Wang X, Wong YC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	12/2004

Abstract:

To study if ectopic Id-1 expression could lead to resistance to chemodrugs, 5-FU, taxol and cisplatin; to examine if the protective role of Id-1 is through inhibition of chemodrug-induced apoptosis; to investigate if MAPK and NF_[kappa]B pathways are involved in the Id-1 induced chemo-protection in NPC cells.

Project Title:	Significance of MAD2 expression to chromosomal instability in prostate cancer
Investigator(s):	Wang X, Wong Y C, Jin D Y
Department:	Anatomy
Source(s) of Funding:	Association for International Cancer Research - General Award
Start Date:	04/2004

Abstract:

To correlate MAD2 expression with genomic instability in prostate cancer specimens; to show that MAD2 expression is essential for a functional mitotic checkpoint in prostate cancer cells; to demonstrate that downregulation of MAD2 leads to mitotic checkpoint defect and increased CIN in prostate cancer cells.• To investigate if promoter hypermethylation contributes to decreased MAD2 expression in prostate cancer

Project Title:	Upregulation of TWIST and its implication as a novel therapeutic target in the treatment of prostate cancer
Investigator(s):	Wang X
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Role of ld-1 in the proliferation of ovarian cancer cells
Investigator(s):	Wang X, Wong YC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Kwok W.K., Wong Y.C. and Wang X., Upregulation of TWIST in prostate cancer and its implication as a therapeutic target, Proceedings of the American Association for Cancer Research, April 2005. 46: 1312 No. 5574.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Wang X., Wong Y.C., Ng I.O.L., Xu R. and Fan S.T., FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation, Carcinogenesis. 2004, 25(12): 2397-2405.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target, Carcinogenesis. 2005, 26(3): 681-687.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Ling M.T., Fung K.L., Wang X. and Wong Y.C., Proteasome mediated degradation of Id-1 is associated with TNF-alpha induced apoptosis in prostate cancer cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 1267 No. 5365.

Wang X., Zhang X., Ling M.T. and Wong Y.C., Inactivation of Id-1 in prostate cancer cells: a potential therapeutic target in inducing chemosensitization, Proceedings of the American Association for Cancer Research, April 2005.. 2005, 46: 529 No. 2252.

Wang X. and Wong Y.C., Induction of tumour cell senescence: a new strategy in anticancer treatment, Medicinal Chemistry Reviews. 2004, 1 No. 3: 1-11.

Wang X., Wong Y.C. and Jin D., Mitotic checkpoint: a therapeutic target in the treatment of human cancer, Letters in Drug Design and Discovery. 2005, 2: 184-193.

Wong Y.C., Ling M.T., Wang X., Ouyang X.S., Cheung A. and Chan F.L., Id-1 protein is a new marker for PCA, In: J. J. Lee, S. A. Li, Antonio Llombart-Bosch, Hormonal Carcinogenesis IV. New York, Springer, 2005, IV: 197-208.

Wong Y.C., Wang X., Ling M.T., Ouyang X.S. and Chan F.L., Prostate Cancer: The Id1 Story, Acta Histochemica ET Cytochemica. 2005, 37(6): 331-337.

Yap Y.L., Zhang X., Ling M.T., Wang X., Wong Y.C. and Danchin A.L.M., Classification between normal and tumor tissues based on the pair-wise gene expression ratio, BMC Cancer . 2004, 4: 72.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Zhou C., Ling M.T., Lee T.K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen independent prostate cancer cells through inactivation of RhoA-GTPase, Proceedings of the American Association for Cancer Research, April 2005. 46: Abstract No. 669.

Researcher : Wong HL

List of Research Outputs

Feng H., Choy M.Y., Deng W., Wong H.L., Lau W.M., Cheung A.N.Y., Ngan H.Y.S. and Tsao G.S.W., Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1), Journal of The Society for Gynecologic Investigation. 2005, 12(4): e21-32.

Researcher : Wong WM

List of Research Outputs

Zeng Y.S., Ding Y., Wu L.Z., Guo J.S., Li H.B., Wong W.M. and Wu W., Co-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Researcher : Wong YC

Project Title:	Induction of breast carcinogenesis by a combination of androgens and oestrogens
Investigator(s):	Wong YC, Xie B
Department:	Anatomy
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1997

Abstract:

To examine the role of both oestrogens and androgens in the initiation and progression of breast carcinogenesis in an animal model.

Project Title:	*The role of Id-1* gene in prostate carcinogenesis and its relationship to invasiveness of prostate cancer**
Investigator(s):	Wong YC, Tam PC, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2001

Abstract:

To compare the status of Id-1 in normal human prostate and prostate carcinoma using immunohistochemical and in situ hybridization approaches and to correlate the levels of expression of Id-1 to the histopathological phenotypes and its relationship to prognosis of prostate cancer; to examine the expression levls of Id-1 of normal prostate cell and several lines of prostate cancer cells (i.e. DU-145, PC-3 and LNCaP) in vitro and its regulation by serum and sex hormones; to examine the relationship of Id-1 expression to the invasiveness of prostate cancer by transfecting the Id-1 gene to cancer cell line (i.e. LNCap) or normal lines which are not constitutively expressing Id-1 protein.

Project Title:	The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian
Investigator(s):	Wong YC, Wang X, Ho KMT, Foster C.S., Na Y.Q., Ke Y.Q., Xin D.Q.
Department:	Anatomy
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Abstract:

To investigate molecular mechanisms responsible for racial differences in prostate cancer incidence.

Project Title:	Id-1 activation of NF-[kappa]B and its role in development of androgen-independent prostate cancer
Investigator(s):	Wong YC, Tsao GSW, Wang X
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To investigate the correlation between the over-expression of Id-1 and activation of NF-[kappa]B in prostate cancer progression; to examine the sensitivity of LNCaP-Id-1 clones towards TNF-[alpha] induced apoptosis; to explore the effect of inhibition of Id-1 expression by antisense Id-1 oligonucleotide on TNF[alpha] induced apoptosis; to study the role of Id-1 gene in development of AI prostate cancer in vivo; to investigate the effect of Id-1 gene silencing on growth of prostate cancer using RNA interference on human prostate cancer xenograft, CWR22.

Project Title:	Id-1 activation of NF-[kappa]B and its role in development of androgen-independent prostate cancer
Investigator(s):	Wong YC, Tsao GSW, Wang X
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Identification and evaluation of specific marker proteins from secretions of benign prostatic hyperplasia (BPH)
Investigator(s):	Wong YC, Tam PC, Wang X, Na Y.Q., Xu K.X., Xin D.Q.
Department:	Anatomy
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2003

Abstract:

To confirm and characterize these proteins in the secretion of BPH by 2-D gel electrophoresis followed by mass spectrometry and mass sequencing; to examine the sources of these differetially expressed proteins including the PSP61, lwPSA and protein X, and to investigate the value of these proteins as markers of BPH; to examine whether these proteins are present in serum and to examine the potential of using these proteins as markers in clinical diagnosis of PBPH; to assess correlation of the levels of these newly identified proteins to PSA levels in prostate cancer and BPH patient and to examine their association with PSA.

Project Title:	The role of Id-1 gene in initiation of prostate carcinogenesis
Investigator(s):	Wong YC, Wang X
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To investigate whether over-expression of Id1 could lead to extension of the life span, possibly immortalization, of HPrE cells; to examine whether Id1 expression in combination with additional factors is able to induce malignant transformation of HPrE cells; to study the molecular mechanisms responsible for the Id1-induced malignant transformation of HPrE cells; to identify novel factors (pathways) responsbile for Id1-induced malignant transformation of HPrE cells.

Project Title:	The role of Id-1 gene in initiation of prostate carcinogenesis
Investigator(s):	Wong YC
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Cheung A., Hui C.M., Cheung P.P.Y., Ling M.T., Tsao G.S.W., Wang X. and Wong Y.C., The helix-loop-helix transcription factor Id-1 promotes cellular proliferation and survival in esophageal carcinoma cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 879 No. 3727.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., MAD2 expression induces chemosensitization to DNA damaging platin, in nasopharyngeal carcinoma cells, Proceeding of the American Association for Cancer Research, April 2005. 46: 1259 No. 5326.

Cheung H.W., Jin D., Ling M.T., Wong Y.C., Wang Q., Tsao G.S.W. and Wang X., Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells, Cancer Research. 2005, 65(4): 1450-1458.

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Kwok W.K., Wong Y.C. and Wang X., Upregulation of TWIST in prostate cancer and its implication as a therapeutic target, Proceedings of the American Association for Cancer Research, April 2005. 46: 1312 No. 5574.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Wang X., Wong Y.C., Ng I.O.L., Xu R. and Fan S.T., FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation, Carcinogenesis. 2004, 25(12): 2397-2405.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Ling M.T., Fung K.L., Wang X. and Wong Y.C., Proteasome mediated degradation of Id-1 is associated with TNF-alpha induced apoptosis in prostate cancer cells, Proceedings of the American Association for Cancer Research, April 2005. 46: 1267 No. 5365.

Si H., Tsao G.S.W., Poon C.S.P., Wong Y.C. and Cheung A., Physical status of HPV-16 in esophageal squamous cell carcinoma, Journal of Clinical Virology. 2005, 32: 19-23.

Wang X., Zhang X., Ling M.T. and Wong Y.C., Inactivation of Id-1 in prostate cancer cells: a potential therapeutic target in inducing chemosensitization, Proceedings of the American Association for Cancer Research, April 2005.. 2005, 46: 529 No. 2252.

Wang X. and Wong Y.C., Induction of tumour cell senescence: a new strategy in anticancer treatment, Medicinal Chemistry Reviews. 2004, 1 No. 3: 1-11.

Wang X., Wong Y.C. and Jin D., Mitotic checkpoint: a therapeutic target in the treatment of human cancer, Letters in Drug Design and Discovery. 2005, 2: 184-193.

Wong Y.C., Ling M.T., Wang X., Ouyang X.S., Cheung A. and Chan F.L., Id-1 protein is a new marker for PCA, In: J. J. Lee, S. A. Li, Antonio Llombart-Bosch, Hormonal Carcinogenesis IV. New York, Springer, 2005, IV: 197-208.

Wong Y.C., Wang X., Ling M.T., Ouyang X.S. and Chan F.L., Prostate Cancer: The Id1 Story, Acta Histochemica ET Cytochemica. 2005, 37(6): 331-337.

Yap Y.L., Zhang X., Ling M.T., Wang X., Wong Y.C. and Danchin A.L.M., Classification between normal and tumor tissues based on the pair-wise gene expression ratio, BMC Cancer . 2004, 4: 72.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Zhou C., Ling M.T., Lee T.K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen independent prostate cancer cells through inactivation of RhoA-GTPase, Proceedings of the American Association for Cancer Research, April 2005. 46: Abstract No. 669.

Researcher : Wu W

Project Title:	The role of neuronal nitric oxide synthase in motoneuron degeneration
Investigator(s):	Wu W
Department:	Anatomy
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To determine the role of injury-induced nNOS in adult spinal motoneurons following root avulsion injury.

Project Title:	Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury
Investigator(s):	Wu W, Yick LW, So KF
Department:	Anatomy
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	11/2003

Abstract:

To study the effects of chondroitinase ABC and lithium chloride on neuronal survival and regneration after spinal cord injury.

Project Title:	Axonal regeneration of CNS neurons after spinal cord injury
Investigator(s):	Wu W
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To examine the effects of lithium chloride (LiC1) and chondroitinase ABC (ChABC) on promoting the survival and regeneration of neurons in the severed Clarke's nucleus (CN) and red nucleus (RN) after spinal cord injury; to investigate how LiC1 and ChABC enhances the axonal regeneration of the severed CN and RN neurons, focusing on both the intracellular signaling and extracellular matrix molecules.

Project Title:	The role of neuronal nitric oxide synthase in motoneuron degeneration
Investigator(s):	Wu W, Huang J
Department:	Anatomy
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To examine the effect of nNOS inhibitors on the expression of injury-induced nNOS and the effect on motoneuron survival and regeneration in adult animals following spinal root avulsion; to investigate the effect of blockage of nNOS expression by antisense nNOS oligodeoxynuleotide (ODN) on motoneuron degeneration and regeneration after root avulsion; to examine how motoneurons respond to axonal injury and whether they can regenerate after root avulsion in nNOS knockout animals; to investigate the effect of nNOS gene silencing on survival and growth of cultured spinal motoneurons using RNA interference technique.

Project Title:	The role of neuronal nitric oxide synthase in motoneuron degeneration
Investigator(s):	Wu W
Department:	Anatomy
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan Y.F., Wu W., McCoy J., Pepinsky B., Sha M. and So K.F., LINGO-1 rescues retinal ganglion cells after optic nerve transaction, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 749.5.

Fu Q., Wu W., Mi S. and So K.F., LINGO-1 Exerts neuroprotection in a rat glaucoma model, ARVO Program Summary Book 2005, Fort Lauderdale, Florida. 2005, 7 No.157-B131.

Gu H.Y., Chai H., Zhang J.Y., Yao Z.B., Zhou L.H., Wong S.M., Bruce I.C. and Wu W., Survival, regeneration & functional recovery of motoneurons after delayed reimplantation of avulsed spinal nerve root in adult rat, Experimental Neurology. 2005, 192: 89-99.

So K.F., Yick L.W., Cheung P.T. and Wu W., Combining lithium chloride and chondroitinase ABC to enhance the regeneration of rubrospinal neurons after spinal cord injury, 9th International Conference on Neural Transplantation and Repair, Taiwan. Taiwan, 2005, 9 No.S2-2.

Yick L.W., So K.F., McCoy J., Pepinsky B., Mi S. and Wu W., LINGO-1 promotes axonal regeneration and functional recovery after spinal cord injury, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 185.3.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons afte spinal cord injury, Neuroscience Letters. 2004, 370 supplement: S38.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons after spinal cord injury, Symposium on "neural plasticity, development and repair", Hong Kong, 2004.

Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury, Journal of Neurotrauma. 2004, 21 no. 7: 932-943.

Yuan Q., So K.F. and Wu W., Age-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomy, Neuroscience Letters. 2004, 370 Supplement: S11.

Yuan Q.J., So K.F. and Wu W., Neuronal and glial reactiions following hypophysectiomy in developing and adult rats, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 758.14.

Zeng Y.S., Ding Y., Wu L.Z., Guo J.S., Li H.B., Wong W.M. and Wu W., Co-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Zeng Y.S., Ding Y., Wu L.Z., Guo J., Li B. and Wu W., Effects of Schwann cells on the survival and differentiation of neural stem cells transplanted into injured spinal cord, Developmental Neuroscience. 2005, 27: 20-26.

Zhang C.W., Lu Q., You S., Zbi Y., Yip H.K.F., Wu W., So K.F. and Cui Q., CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury, Investigative Ophthalmology and Visual Science. 2005, 46 No. 4: 1497-1503.

Researcher : Yeung SC

List of Research Outputs

Yeung S.C. and Yip H.K.F., Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina, NeuroReport. 2005, 6 No.7: 673-676.

Yeung S.C. and Yip H.K.F., Expression of inhibitor of DNA binding, Id3, in the mouse retina during postnatal development, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Yeung S.C., Expression of regulatory helix-hoop-helix factor Id2 protein in the developing and adult mouse retina. 2004, 92.

Researcher : Yick LW

Project Title:	Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation
Investigator(s):	Yick LW, Chan SY
Department:	Paediatrics & Adolescent Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To understand the role of EGF in chondrocyte differentiation using our 'knock-in mice' with targeted expression of EGF in prehypertrophic chondrocytes.

List of Research Outputs

Yick L.W., So K.F., McCoy J., Pepinsky B., Mi S. and Wu W., LINGO-1 promotes axonal regeneration and functional recovery after spinal cord injury, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 185.3.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons afte spinal cord injury, Neuroscience Letters. 2004, 370 supplement: S38.

Yick L.W., So K.F. and Wu W., Lithium chloride and chondroitinase ABC promote axonal regeneration of rubrospinal neurons after spinal cord injury, Symposium on "neural plasticity, development and repair", Hong Kong, 2004.

Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury, Journal of Neurotrauma. 2004, 21 no. 7: 932-943.

Researcher : Yip HKF

Project Title:	The role of microglia in the survival of retinal ganglion cells (RGCs) following transient retinal ishemia
Investigator(s):	Yip HKF, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To study the effects of: (1) Ischemia on the survival of RGCs and microglial response; (2) Neurotrophic factors (CNTF, BDNF, and bFGF) and cytokines (TGF-[gamma], IL-4, IL-10, TNF-[gamma], CSF-1, and IFN-/LPS) on the survival of RGCs and microglial response after transient retinal ischemia; (3) Neurotrophic factors and cytokines on the microglia from ischemic retina in vitro.

Project Title:	Expression of basic Helix-Loop-Helix transcription factors in the retinal ganglion cells after axonal injury
Investigator(s):	Yip HKF, Tsao GSW, Wang X
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	01/2005

Abstract:

To examine (1) the changes in the expression of several HLH transcription factors that function as negative regulators of neurogenesis and axonal outgrowth induced by axonal injury; and (2) the expression of these negative HLH transcription factors and the vulnerability of neurons to apoptosis.

Project Title:	In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death
Investigator(s):	Yip HKF, Tsao GSW, Chung SK
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2005

Abstract:

refer to hard copy proposal

List of Research Outputs

Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Neuroscience Letters 370S. 2004, S11.

Lau W.M., Wong A.O.L., Tsao G.S.W., So K.F. and Yip H.K.F., Molecular cloning and expression of telomerase reverse transcriptase (TERT) in zebrafish central nervous system, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Li S., Hu B., Tay D.K.C., So K.F. and Yip H.K.F., Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats, Brain Research. 2004, 1029: 56-64.

Yeung S.C. and Yip H.K.F., Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina, NeuroReport. 2005, 6 No.7: 673-676.

Yeung S.C. and Yip H.K.F., Expression of inhibitor of DNA binding, Id3, in the mouse retina during postnatal development, Annual Scientific Meeting Hong Kong Society of Neurosciences . 2004.

Yip H.K.F. and Lau W.M., Expression pattern of telomerase reverse transcriptase (TERT) in the developing mouse retina, Society for Neuroscience Annual Meeting. 2005.

Yip H.K.F., Lau W.M., Tsao G.S.W., So K.F. and Wong A.O.L., Zebrafish telomerase catalytic subunit: Molecular cloning and characterization of a ribonucleoprotein reverse transcriptase gene highly expressed in the retina, Association for Research in Vision and Ophthalmology Annual Meeting. 2005.

Zhang C.W., Lu Q., You S., Zbi Y., Yip H.K.F., Wu W., So K.F. and Cui Q., CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury, Investigative Ophthalmology and Visual Science. 2005, 46 No. 4: 1497-1503.

Zhi Y., Lu Q., Zhang C.W., Yip H.K.F., So K.F. and Cui Q., Different optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophoc factor but not neurotrophin-4/5, Brain Research. 2005, 1047: 224-232.

Researcher : You S

List of Research Outputs

Zhang C.W., Lu Q., You S., Zbi Y., Yip H.K.F., Wu W., So K.F. and Cui Q., CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury, Investigative Ophthalmology and Visual Science. 2005, 46 No. 4: 1497-1503.

Researcher : Yu E

List of Research Outputs

He M., Cheung Z.H.Y., Yu E., Tay D.K.C. and So K.F., Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters, Neurochemical Research. 2004, 29 No. 11: 2153-2161.

Researcher : Yu MS

List of Research Outputs

Chang R.C.C., Yu M.S., Suen K.C., Lai S.W., Kwok N.S. and Hugon J., Differential signaling of unfolded protein responses (UPR) and endoplasmic reticulum (ER) stress in neurons exposed to b-amyloid peptide, Society for Neuroscience. 2004, Program No. 1000.22.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Yu M.S., Lai S.W., Lin K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Characterization of polysaccharides from the folowers of Nerium indicum and their neuroprotective effects, International Journal of Molecular Medicine. 2004, 14: 917-924.

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Protein kinases as technological platforms to screen neuroprotective agents from Chinese medicine, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 69 No.P-36.

Researcher : Yu MS

List of Research Outputs

Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Evaluation of endoplasmic reticulum stress in beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2004, 370 suppliement 1: S16.

Researcher : Yuan Q

List of Research Outputs

Yuan Q., So K.F. and Wu W., Age-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomy, Neuroscience Letters. 2004, 370 Supplement: S11.

Researcher : Yuan QJ

List of Research Outputs

Yuan Q.J., So K.F. and Wu W., Neuronal and glial reactiions following hypophysectiomy in developing and adult rats, The 34 Annual Meeting of Society for Neuroscience. 2004, Program No. 758.14.

Yuan Q.J., The plasticity of hypothalamic magnocellular system following axonal damage by hypophysectomy in developing and adult rats. 2004, 123 pages.

Researcher : Zhang X

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Wang X., Zhang X., Ling M.T. and Wong Y.C., Inactivation of Id-1 in prostate cancer cells: a potential therapeutic target in inducing chemosensitization, Proceedings of the American Association for Cancer Research, April 2005.. 2005, 46: 529 No. 2252.

Zhang X., Ling M.T., Feng H., Wong Y.C., Tsao G.S.W. and Wang X., Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells, British Journal of Cancer. 2004, 91: 2042-2047.

Researcher : Zhou C

List of Research Outputs

Kwok W.K., Ling M.T., Lee D.T.W., Lau T.C.M., Zhou C., Zhang X., Chua C.W., Chan K.W., Chan F.L., Glackin C., Wong Y.C. and Wang X., Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Research. 2005, 65(12): 5153-5162.

Ling M.T., Lau T.C.M., Zhou C., Chua C.W., Kwok W.K., Wang Q., Wang X. and Wong Y.C., Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF), Carcinogenesis. 2005, 26(10): 1668-1676.

Zhou C., Ling M.T., Lee T.K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen independent prostate cancer cells through inactivation of RhoA-GTPase, Proceedings of the American Association for Cancer Research, April 2005. 46: Abstract No. 669.

Researcher : Zhou C

List of Research Outputs

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