DEPT OF CHEMISTRY

Researcher : An H



List of Research Outputs

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Researcher : An XM



List of Research Outputs

 

An X.M., Functional Characterization of Cell-Cycle Related Kinase (CCRK) in Glioblastoma and Colon Cancer Carcinogenesis (PhD Thesis) . 2008.

 

Researcher : Brown GD



Project Title:

Gradient diffusion-attenuated NMR spectroscopy for the analysis of multi-component mixtures

Investigator(s):

Brown GD

Department:

Chemistry

Source(s) of Funding:

Other Funding Scheme

Start Date:

12/1994

 

Abstract:

Spectroscopic analysis of multi-component mixtures has always required a physical separation of the components by some chromatographic technique prior to the acquisition of a characteristic spectrum from each component. In recent years there has been a poliferation of "hyphenated" techniques based on this very principle. The modern capability to generate magnetic-field gradients in NMR Spectroscopy opens up the possibility of differentiating compounds by their diffusion characteristics. The project aims to investigate whether this molecular property can be applied to resolve different components when present simultaneously in the same mixture. If successful, NMR analysis of complex mixtures would then be as simple a matter as NMR analysis of ind ividual compounds, and the need for prior chromatography will have been removed, resulting in greater simplicity and wider applicability of NMR in the analysis of multi-component mixtures.

 

 

Researcher : But YS



List of Research Outputs

 

But Y.S. and Toy P.H., The Mitsunobu Reaction: Origin, Mechanism, Improvements, and Application , Chemistry -- An Asian Journal. 2007, 2: 1340-1355.

 

Researcher : Chan CL



List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Researcher : Chan CY



List of Research Outputs

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Researcher : Chan GKY



Project Title:

Electrochmeical oxidation of glucose

Investigator(s):

Chan GKY

Department:

Chemistry

Source(s) of Funding:

Outstanding RGC Projects

Start Date:

09/1998

 

Abstract:

The electrochemical oxidation of glucose on some inorganic electrodes will be studied. These electrodes appeared to have better activities than others reported in the literature. Investigations are planned to identify the oxidation products and hence the mechanism of the glucose oxidation process. Furthermore kinetics studies will be made on well characterized surfaces so that the effects of surface morphology and composition on catalytic activity can be determined. The results of these studies will help in the design of better catalytic electrodes for glucose oxidation and will be used to help in the development of a glucose sensor. The applications of these electrodes as glucose sensors will be assessed. Tests will be made for determination of glucose concentration in serum. Anti-fouling, anti-interference, linearity, and selectivity of a glucose sensor using the new catalyst will be evaluated.

 

Project Title:

Fuel cell research towards a clean environment

Investigator(s):

Chan GKY, Che CM

Department:

Chemistry

Source(s) of Funding:

The University of Hong Kong Foundation Seed Grant

Start Date:

03/2001

 

Abstract:

To accelerate and broaden existing fuel cell research, to foser external links and collaborations.

 

Project Title:

Controlled macroporous and mesoporous structures for gas-diffusion, gas-evolving, and fuel-cell electrodes

Investigator(s):

Chan GKY

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2003

 

Abstract:

To synthesize and explore conducting materials with controlled nanostructures, macrostructures, and chemical composition for several electrochemical applications and their optimum performance.

 

Project Title:

Efficient extraction of trace precious metals in industrial effluents via novel water compatible PEG/PS solid-phase separable

Investigator(s):

Chan GKY, Ng DCL, Toy PH, Wong KO

Department:

Chemistry

Source(s) of Funding:

Matching Grant for Joint Research

Start Date:

11/2005

 

Abstract:

A process technology will be developed to recover gold and silver in waster water collected from electroplating, electronics and other industries. The challenges are to efficiently scavenge low concentrations (mg/L) of metal salts so that the final concentrations in the discharge are down to ug/L level with an economical and environmentally friendly procedure.

 

Project Title:

Selectivity and Transport of Ions and Water in a Silica Nanotube

Investigator(s):

Chan GKY

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To conduct computer simulations at the molecular and atomic level to investigate how ions and water interact with each other and with atoms on the silica surface; to probe and quantify the fluid-solid interactions by modeling the silica surfaces with several structural and functional group variations giving different polarity, charges, and hydrophobicity; to learn how the geometry and surface type of the nanotube will influence selectivity, diffusion, and conductivity of ions and water confined inside the nanopore.

 

Project Title:

Generation of ozone in water via novel electrode materials

Investigator(s):

Chan GKY, Li XY

Department:

Chemistry

Source(s) of Funding:

Innovation and Technology Support Programme

Start Date:

09/2006

 

Abstract:

The performance of the novel electrode material in ozone generation is commercially competitive by several folds compared to conventional corona discharge method. This competitive performance need to be sustained over months of operation, by additional innovation in materials development. From an existing prototype of a single cell design, a scale up design with multiple stacked cells need to be developed to demonstrate the feasibility of the technology for a realistic scale.

 

Project Title:

Electrochemical generation of ozone from water using novel doped tin oxide electrode

Investigator(s):

Chan GKY, Li XY

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2006

 

Abstract:

(1) Study effects of operation parameters in a large electrode with convective flow. (2) Investigate the alternative of hydrogen co-production. (3) Investigate the alternative of aerated anode (4) Evaluate alternative electrode preparation methods for optimum ozone generation (5) Correlate ozone generation to materials properties.

 

Project Title:

Multi-Scale Modeling of Electrochemcal Reactions in Porous Electrodes

Investigator(s):

Chan GKY

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

In recent years, a large variety of nanoporous materials of different structures were synthesized. One approach of structuring in the mesoscopic scale (2-50 nm) was to use structure directing agents like ionic surfactants or tri-block polymeric surfactants in the synthesis. Some notable examples of silicas such as MCM[1], SBA[2,3], FDU[4] were produced to possess uniform ordered pores with tunable sizes. Carbonization of these silica structures lead to various mesoporous structures such as the CMK carbons [5,6]. Applications of these materials to electrochemical applications are promising and studies of fuel cell electrode reactions have been reported[7]. Integrating these mesoporous carbons with larger scale structures lead to further improvement in the mass transport processes. The interpretation of the experimental results of these complex electrochemical processes in the multiple scale structures becomes difficult and demands the corresponding development of appropriate theoretical analyses. The objective of this research is to develop a mathermatical model to describe the integrated process of electrochemical kinetics, ionic transport, and mass-transfer in the various structures with multiple-scale porosity. The development will start from the fundamental principles such as Bullter-Volmer equations, Laplace equations of concentration and electric potential fields. The nano-confinement effect on diffusion of ions and reactants will also be considered. The model will be applied to interpret experimental data generated in our laboratory and available in the literature for electrode materials with various nanoporous and mesoporous structures. The results of this work will lead to understanding better the critical parameters affecting performance of electrodes with novel structures. [1] C. T. Kresge, M. E. Leonowicz, W. J. Roth, J. C. Vartuli and J. S. Beck, Nature 359, 710. [2] D. Zhao, J. Feng, Q. Huo, N. Melosh, G. H. Fredrickson, B. F. Chmelka and G. D. Stucky, Science, 279(1998)548. [3] D. Zhao, Q. Huo, J. Feng, B. F. Chmelka and G. D. Stucky, J. Am. Chem. Soc., 120(1998)6024. [4] J. Fan, C. Yu, F. Gao, J. Lei, B. Tian, L. Wang, Q. Luo, B. Tu, W. Zhou and D. Zhao, Angew. Chem., Int. Ed., 42(2003)3146. [5] R. Ryoo, S. H. Joo, S. J. Jun, Phys. Chem. B 103(1999)7743. [6] Jun, S.; Joo, S. H.; Ryoo, R.; Kruk, M.; Jaroniec, M.; Liu, Z.; Ohsuna, T.; Terasaki, O. J. Am. Chem. Soc., 122(2000)10712. [7] K.Y. Chan, J. Ding, J. Ren, S.A. Cheng, and K.Y. Tsang, J. Mater. Chem, 14 (2004) 505-516.

 

List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrodeaterial, Keynote Lecture at 2007 American Institute of Chemical Engineers (AICheE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material , Keynote Lecture at 2007 World Cougress on Ozone and Ultraviolet Technologies (IUTA), August 27-29, 2007, Los Angeles, California, U.S.A.. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Chan G.K.Y., Non-Equilibrium Molecular Dynamics Simulations of Yttria-Stabilized Zirconia Under an Alternating Electric Field, Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Chan G.K.Y. and Zhang Q., Non-Equilibrium Molecular Dynamics Simulations of Yttria-Stabilized Zirconia Under an Alternating Electric Field, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A. November 4-9, 2007.

 

Chan G.K.Y., Regional Editor (From January 1, 2005 - present), Molecular Simulation . 2007.

 

Chan G.K.Y., Regional Editor (From January 1, 2006 - Present) , Journal of Experimental Nanoscience . 2007.

 

Chan G.K.Y., Strategies of Nanostructing Fuel Cell Electrodes , Keynote Lecture at First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007. 2007.

 

Chan G.K.Y., Ren J., Wang H. and Ding J., Strategies of Nanostructing Fuel Cell Electrodes , Proceedings of 2007 First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007.

 

Cheng S. and Chan G.K.Y., High-Voltage Dual Electrolyte Electrochemical Power Sources, United States Patent No. US7,344,801 B2 . 2008.

 

Zhang Q. and Chan G.K.Y., Alternate Current Nonequilibrium Molecular Dynamics Simulations Of yttria-stabilized Zirconia , Journal Of Physical Chemistry C. 2007, 11: 15832-15838.

 

Researcher : Chan HY



List of Research Outputs

 

Yu C., Chan H.Y., Wong M.C. and Yam V.W.W., Polyelectrolyte-induced Self-assembly of Positively Charged Alkynylplatinum(II) - Terpyridyl Complexes in Aqueous Media , Chemistry - A European Journal. 2008, 4577-4584.

 

Researcher : Chan KWQ



List of Research Outputs

 

Lai S.W., Chan K.W.Q., Zhu N. and Che C.M., cis-Dicyanoosmium(II) Diimine Complexes Bearing Phosphine or Sulfoxide Ligands: Spectroscopic and Luminescent Studies, Inorganic Chemistry. Washington, D.C., American Chemical Society, 2007, 46: 11003-11016.

 

Researcher : Chan KWY



List of Research Outputs

 

Chan K.W.Y. and Wong W.T., Small Molecular Gadolinium(III) Complexes as MRI Contrast Agents for Diagnostic Imaging , Coordination Chemistry Reviews . 2007, 251: 2428-2451.

 

Researcher : Chan LF



List of Research Outputs

 

Chan L.F., Synthesis, Structures and Properties of Metal-Metal Bonded Transition Metal with Organothiolate Ligands (PhD Thesis) . 2008.

 

Researcher : Chan LLY



List of Research Outputs

 

Shi X., Lin J., Peng Y., Chan L.L.Y., Kung H.F., Lin M.C. and Huang R., Artificial Cold Exposure Induced Stroke in Renovascular Hypertensive Rats and its Association with Cold-inducible RNA Binding Protein mRNA Expression in Brain Tissue and Blood Pressure, Neural Regeneration Research. 2007, 2: 455-60.

 

Researcher : Chan PWH



Project Title:

Synthesis and applications of transition metal-nitrogen multiple bonded complexes in carbon-nitrogen bond formation reactions

Investigator(s):

Chan PWH, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To develop the chemistry of highly reactive metal-nitrogen multiple bonded complexes.

 

 

Researcher : Chan PY



List of Research Outputs

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Chan SC



List of Research Outputs

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Researcher : Chan SH



List of Research Outputs

 

Chan S.H., Non-heme Iron(III) and Gold(III) Complexes with Dicarboxamide Ligands: Synthesis, Structures and Anti-cancer Properties (PhD Thesis) . 2007.

 

Researcher : Chan WK



Project Title:

Fabrication of photovoltaic devices by polyelectrolyte deposition

Investigator(s):

Chan WK, Djurisic A

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2003

 

Abstract:

To prepare a series of ionic polymers that can function as photosensitizers and charge transport materials, and can be fabricated to multilayer structures by the layer-by-layer deposition process; to modify the device structures by using different combination of sensitizers, n- and p-type charge carriers, and mixed layers; to study the photoconducting and photovoltaic properties of the devices fabricated using different light sources; to simulate the experimental results into theoretical models in order to understand different physical processes such as photo charge generation, exciton diffusion, and interference effect.

 

Project Title:

Use of Transition Metal Complexes in Heterojunction Photovoltaic Devices

Investigator(s):

Chan WK, Djurisic A

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To synthesize a series of sublimable transition metal complexes that can be processed by caccuum deposition; to fabricate photovoltaic devices with different structures using the metal complexes as photosensitizers/change carriers; to optimize the device performance by fabricating devices with different structures, using different charge transport layers, or modifying the electrode surfaces; to study the roles of these complexes in photosensitization, exciton separation, exciton diffusion, and charge transport processes.

 

Project Title:

Fabrication of nanostructures using functional block copolymers as the templates

Investigator(s):

Chan WK, Djurisic A

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2005

 

Abstract:

The objectives of this project are: 1. To design and synthesize functional block copolymers that can serve as the templates for subsequent nanofabrication. 2. To characterize the solid-state bulk and surface morphology of the resulting block copolymers, and to deposit various types of semiconducting nanoparticles/polyelectrolytes by the electrostatic adsorption process. 3. To fabricate photovoltaic devices based on the nanoparticles-polymer composite, and to study the device performance. 4. To fabricate two dimensional nanoparticles ensembles on a functional block copolymer surface and to study the potential of using these structures as photonic crystals, optical filters, and/or Bragg mirrors.

 

Project Title:

Study of photocurrent generation in polymeric photovoltaic devices

Investigator(s):

Chan WK

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

1. To fabricate photovoltaic cells by using some metal containing polymers synthesized in our laboratory. The active layer will be based on polymer blends composed of photosensitizing and charge transport polymers. 2. To study the transient photocurrent profile of polymer-based devices upon light irradiation. 3. To simulate the photocurrent rise and decay profiles by fitting the experimental results with theoretical model.

 

Project Title:

Synthesis, spectroscopy and OLED application of triplet emitters containing charge transport moieties

Investigator(s):

Chan WK, Mak SK

Department:

Chemistry

Source(s) of Funding:

Germany/Hong Kong Joint Research Scheme

Start Date:

01/2007

 

Abstract:

1. To synthesize, characterize, and to test new functionalized triplet emitters for OLED (organic light emitting diode) applications. 2. To improve the electroluminescence quantum yield, and to lengthen the device lifetime Triplet emitters for this new technology attract many research groups in universities and industrial laboratories, since the maximum obtainalbe efficiency of these materials can be by a factor of four times higher than that of pure organic molecules. The new compounds will contain charge transport moieties and are designed to enhance the electron-hole recombination probability.

 

List of Research Outputs

 

Chan W.K., Coordination Polymers For Solar Energy Conversion Processes, International Symposium on Catalysts and Fine Chemicals, Nanyang Technological University, Singapore, December 17-20, 2007. . 2007.

 

Chan W.K., Heterocyclic Aromatic Conjugated Polymers For Opto-Electronic Applications, The Fifth International Symposium on Polyimides and Other High Temperature Polymers, Orlando, November 5-7, 2007. . 2007.

 

Chan W.K., Metal Containing Polymers For Organic Solar Cells, UK-Hong Kong Frontiers of Science Symposium, Hong Kong, January 15-18, 2008.. 2008.

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Metal containing polymers with heterocyclic rigid main chains, Coordination Chemistry Reviews. ELSEVIER SCIENCE SA, 2007, 251: 2104-2118.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Chan W.K., The Use of Transition Metal Complexes as Photosensitizers in Organic Photovoltaic Devices, International workshop on organic and organic/inorganic composite optoelectronic materials and devices (IWOCOMD 2008), 5-7 June 2008, Hangzhou, China. . 2008.

 

Chan W.K., The Use of Transition Metal Complexes as Photosensitizers in Organic Photovoltaic Devices, International workshop on organic and organic/inorganic composite optoelectronic materials and devices (IWOCOMD 2008), 5-7 June 2008, Hangzhou, China. . 2008.

 

Cheng K.W., Mak S.K., Chan W.K., Ng M.C.A. and Djurisic A., Synthesis of conjugated polymers with pendant ruthenium terpyridine trithiocyanato complexes and their applications in heterojunction photovoltaic cells, Journal of Polymer Science: Part A: Polymer Chemistry. Wiley Periodicals, Inc., 2008, 46: 1305-1317.

 

Djurisic A., Tam K.H., Cheung C.K., Leung Y.H., Ling F.C.C., Beling C.D., Fung S.H.Y. and Chan W.K., Defect in zinc oxide nanostructures synthesized by a hydrothermal method, In: Z.K. Tang, P. Sheng, Nanoscale Phenomena: Basic Science to Device Applications. Springer, 2008, Chapter 10: 117-130.

 

Djurisic A., Tam K.H., Hsu Y.F., Zhang S., Xie M.H. and Chan W.K., GaN nanowires--influence of the starting material on nanowire growth, Thin Solid Films. Amsterdam, Elsevier B.V., 2007, 516: 238-242.

 

Hsu Y.F., Xi Y., Yip C.T., Djurisic A. and Chan W.K., Dye-sensitized solar cells using ZnO tetrapods, Journal of Applied Physics. New York, American Institute of Physics, 2008, 103: 083114: 1-4.

 

Hsu Y.F., Djurisic A., Tam K.H., Cheung K.Y. and Chan W.K., Fabrication and characterization of ZnO/TiOx nanoscale heterojunctions, Journal of Crystal Growth. Amsterdam, Elsevier B.V., 2007, 307: 348-352.

 

Hsu Y.F., Xi Y., Djurisic A., Chan W.K., Yip C.T. and Tam K.H., Hydrothermal growth of periodic ZnO nanorod arrays using polystyrene sphere templates, Proceedings of SPIE. 2007, 6639: 66390I: 1-8.

 

Hsu Y.F., Xi Y., Tam K.H., Djurisic A., Luo J., Ling F.C.C., Cheung C.K., Ng M.C.A., Chan W.K., Deng X., Beling C.D., Fung S.H.Y., Cheah K.W., Fong P.W.K. and Surya C.C., Undoped p-type ZnO nanorods synthesized by a hydrothermal method, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 1020-1030.

 

Hsu Y.F., Xi Y., Djurisic A. and Chan W.K., ZnO nanorods for solar cells: Hydrothermal growth versus vapor deposition, Applied Physics Letters. New York, American Institute of Physics, 2008, 92: 133507: 1-3.

 

Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134.

 

Leung Q.Y., Mak S.K., Tam W.Y. and Chan W.K., Fabrication of Rhenium Containing Narrow Band Gap Polymer for Photovoltaic Applications , Abstract of Europolymer Confernece, 2008, Gargnano (BS-Italy), June 1-5, 2008. Gargnano, Italy, Poster ref. P.30.

 

Leung Y.H., Djurisic A., Liu Z., Li D., Xie M.H. and Chan W.K., Defect photoluminescence of ZnO nanorods synthesized by chemical methods, Journal of Physics and Chemistry of Solids. Amsterdam, Elsevier Ltd., 2008, 69: 353-357.

 

Li D., Liu Z., Leung Y.H., Djurisic A., Xie M.H. and Chan W.K., Transition metal-doped ZnO nanorods synthesized by chemical methods, Journal of Physics and Chemistry of Solids. Amsterdam, Elsevier Ltd., 2008, 69: 616-619.

 

Mak S.K. and Chan W.K., Electroluminescence from metal containing polymers and metal complexes with functional ligands, In: Hartmut Yersin, Highly efficient OLEDs with phosphorescent materials. Germany, Wiley-VCH, 2007, 329-362.

 

Ng M.C.A., Djurisic A., Tam K.H., Cheng K.W., Chan W.K., Tam H.L., Cheah K.W., Lu A.W., Chan J. and Rakić A.D., 3,4,9,10-Perylenetetracarboxylicdiimide as an interlayer for ultraviolet organic light emitting diodes, Optics Communications. Amsterdam, Elsevier B.V., 2008, 281: 2498-2503.

 

Ng M.C.A., Djurisic A. and Chan W.K., Organic luminescent nanowires – fabrication and characterization, SPIE Photonics Asia, Beijing, November 11-15, 2007. 6828: 682807: 1-10.

 

Ng M.C.A., Djurisic A., Tam K.H., Kwok W.M., Chan W.K., Tam W.Y., Phillips D.L. and Cheah K.W., Organic nanoclusters on inorganic nanostructures for tailoring the emission properties of organic materials, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 566-574.

 

Pandey A.K., Nunzi J.M., Wang H., Oey C.C., Djurisic A., Xie M.H., Leung Y.H., Man K.K.Y. and Chan W.K., Reverse biased annealing: Effective post treatment tool for polymer/nano-composite solar cells, Organic Electronics. Amsterdam, Elsevier B.V., 2007, 8: 396-400.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Tong W.Y., Li Z.X., Djurisic A., Chan W.K. and Yu S.F., Field emission from copper phthalocyanine and copper hexadecafluorophthalocyanine nanowires, Materials Letters. Amsterdam, Elsevier B.V., 2007, 61: 3842-3846.

 

Tse C.W., Cheng K.W. and Chan W.K., Synthesis of Hyperbranched Polymers with Rhenium(I) Bis(Stilbazoylimino)Acephthalene Complexes at the Branching Units, Journal of Inorganic and Organometallic Polymers and Materials. Springer Science, 2007, 18: 59-68.

 

Wong W.Y., Wang X.Z., He Z., Djurisic A., Yip C.T., Cheung K.Y., Wang H., Mak S.K. and Chan W.K., Metallated conjugated polymers as a new avenue towards high-efficiency polymer solar cells, Nature Materials. Nature Publishing Group, 2007, 6: 521-527.

 

Wong W.Y., Wang X.Z., He Z., Chan K.K., Djurisic A., Cheung K.Y., Yip C.T., Ng M.C.A., Xi Y., Mak S.K. and Chan W.K., Tuning the absorption, charge transport properties, and solar cell efficiency with the number of thienyl rings in platinum-containing poly(aryleneethynylene)s, Journal of the American Chemical Society. American Chemical Society, 2007, 129: 14372-14380.

 

Xi Y., Li D., Djurisic A., Xie M.H., Man K.K.Y. and Chan W.K., Hydrothermal synthesis vs electrodeposition for high specific capacitance nanostructured NiO films, Electrochemical and Solid-State Letters. The Electrochemical Society, 2008, 11: D56-D59.

 

Xi Y., Hsu Y.F., Djurisic A., Ng M.C.A., Chan W.K., Tam H.L. and Cheah K.W., NiO/ZnO light emitting diodes by solution-based growth, Applied Physics Letters. New York, American Institute of Physics, 2008, 92: 113505: 1-3.

 

Yip C.T., Cheung K.Y., Djurisic A. and Chan W.K., Titania nanotube array based photovoltaic cells, Proceedings of SPIE. 2007, 6656: 665616: 1-11.

 

Researcher : Chan WS



List of Research Outputs

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Researcher : Chan WT



Project Title:

Development of a Novel Bottom-Viewed Inductively Coupled Plasma Atomic Emission Spectrometry

Investigator(s):

Chan WT

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To improve the analytical performance of bottom-viewed inductively coupled plasma atomic emission spectrometry (BV-ICP); to study the characteristics of BV-ICP.

 

Project Title:

Optimization of photochemical decomposition–fluorescence (PCF) measurement of pyrethroids in vegetables and tealeaves

Investigator(s):

Chan WT

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

06/2006

 

Abstract:

Pyrethroids refer to derivatives of pyrethrum which is a natural pesticide extracted from Chrysanthemums [1]. Pyrethroid is the largest group of environment friendly pesticides in the world. Pyrethroids are practically nontoxic to birds, but are very toxic to fish and aquatic invertebrates. Pyrethroids break down rapidly in the environment to less toxic compounds. The pesticide is a viable alternative to persistent organic pesticides (POP) such as DDT. Pyrethroids, however, pose certain toxic effects on humans. Pyrethroids affect the nervous system by interacting with the sodium channels of the neuronal membranes and will lead to seizures on high dose. Pyrethroids are endocrine disruptors and may cause damage to the liver upon long-term exposure. The USEPA also identifies pyrethroids as potential carcinogens. Stringent control on the maximum residue level (MRL) in foodstuffs, especially on vegetables and agricultural products, has, therefore, imposed by various countries in recent years. For example, the European Union requirement of MRL of pyrethroids on tealeaves is 0.02–0.1 mg/Kg in Year 2000, orders of magnitude larger than the previous MRL requirement. Proper control of pyrethroid content in foodstuffs is essential, especially for the foodstuffs for export. Determination of the pyrethroid content is the first step in quality control of the foodstuffs. Determination of the pyrethroid residue on agricultural products at 0.01 mg/Kg levels requires highly sensitive instrumental methods, such as gas chromatography-mass spectrometry (GC-MS) [2]. GC-MS requires tedious and meticulous extraction and cleanup processes of the analytes because of low tolerance of sample matrix by the GC column. GC-MS instruments are also relatively expensive and will add to the cost of the agricultural products, if not unaffordable to the producers / exporters. An alternative to GC separation is high performance liquid chromatography (HPLC). However, the sensitivity of conventional UV-absorption detection method of HPLC does not meet the MRL requirement. False negative on pyrethroid determination will result in health hazards to the consumers of the agricultural products. False negative will also result in rejection of the products by importing countries and cause financial losses. Post-column photochemical decomposition of pyrethroids and fluorescence measurement of the decomposition products has been demonstrated to be a viable detection method of pyrethroids after HPLC separation. The method is based on the conversion of non-fluorescent analytes into strongly fluorescent photoproducts by UV irradiation. Detection limits of 0.01 mg/Kg are readily achievable [3,4]. The best limits of detection reported in the literatures are in the range of 0.01 to 0.22 μg/Kg in vegetable samples using coupled-column HPLC [5]. In addition to the high sensitivity, the post-column photochemical decomposition–fluorescence (PCF) method is attractive in that photons are used as a reagent in the derivatization reaction [4]. Introduction of photons into the HPLC eluent does not cause turbulence in the HPLC flow and will not result in band broadening of the HPLC peaks. The flux of photons can also be adjusted readily and switched off completely as necessary. Depending on the photochemical reaction and the photon flux, the reaction typically takes more than a minute to complete. A relatively large dead volume of the post-column photochemical reactor is, therefore, needed to allow for the relatively long residence time of the HPLC eluent in the reactor. To avoid significant band broadening, the reactor volume is typically reduced, in the expense of the completeness of the photochemical reaction. For example, the fluorescence intensity of the photoproducts of five pyrethroids increases monotonically as the flow rate eluting solvent reduces [3], an indication of incomplete reaction. We propose to further refine the PCF method. The decomposition conditions, e.g., wavelength and power of the light source, irradiation duration, solvent and additives, and temperature, will be optimized for maximum fluorescence intensity and minimum interference from the sample matrix. The decomposition products will be identified using mass spectrometry. Knowledge of the decomposition products and mechanism is needed to select the decomposition conditions intelligently. Photodegradation products of various environmentally important compounds, e.g., dipheyl ethers [6], have been studied using mass spectrometry. Mass spectrometric studies of photodegradation of pyrethroids, however, are lacking. The objectives of the research proposal are: 1. To develop a photoreactor for post-column pyrethroid determination. 2. To optimize the operating parameters of the photoreactor for maximum sensitivity and minimum band broadening. 3. To study the photodegradation products of pyrethroids using mass spectrometry with the aim of further optimization of the performance of the photoreactor. Reference: 1. Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, “Toxicological Profile Information Sheet”, http://www.atsdr.cdc.gov/toxprofiles/tp155-c2.pdf, accessed on November 14, 2005. 2. Y.C. Li, J. Yi, Z.B. Bong, S.B. Zhang, and W.H. Zheng, “Determination of Cypermethrin and Fenvalerate Residues in Tea by Reversed-Phase High Performance Liquid Chromatography”, J. Xiamen University (Natural Science), 2003, 42, 78-82. 3. T. López-López, M.D. Gil-Garcia, J.L. Mart´ınez-Vidal, M. Mart´ınez-Galera, Determination of pyrethroids in vegetables by HPLC using continuous on-line post-elution photoirradiation with fluorescence detection, Analytica Chimica Acta, 2001, 447, 101111. 4. M. Lores, O. Cabaleiro, R. Cela, Post-Column photochemical derivatization in high-performance liquid chromatography”, Trends Anal. Chem., 1999, 18, 392–400. 5. P. Parrilla Va´zquez, M.D. Gil Garcı´a, D. Barranco Martı´nez, M. Martı´nez Galera, Application of coupled-column liquid chromatography combined with post-column photochemically induced fluorimetry derivatization and fluorescence detection to the determination of pyrethroid insecticides in vegetable samples”, Anal. Bioanal. Chem., 2005, 381, 1217–1225. 6. L. Sanchez-Prado, M. Llompart, M. Lores, C. Garcia-Jares, R. Cela, “Investigation of photodegradation products generated after UV-irradiation of five polybrominated diphenyl ethers using photo solid-phase microextraction”, J. Chrom. A, 2005, 1071, 85–92.

 

Project Title:

Study of sorption of heavy metals on individual cells of Chlorella vulgris by time-resolved Inductively Coupled Plasma-Mass Spectrometery

Investigator(s):

Chan WT

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/2007

 

Abstract:

Algae are effective agent for bioremediation of the environment. The sportion capacity of heavy metals by algae is in the range of 0.1 to 10 mmol/g [1]. The metals are taken up at the cell surface via biosorption and/or internally via metabolic uptake [2]. The algae surface is populated with functional groups for metal binding. These groups include hydroxyl, carbonyl, carboxyl, sulfhydryl, thioether, sulfonate, amine, imine, amide, imidazole, phosphonate, and phosphodiester [3]. Biosorption on the cell surface is mainly an ion exchange process. Studies on the adsorption equilibrium and kinetics for various combinations of metals and algae have been reported [4,5]. The adsorption process is rapid but is sensitive to ambient conditions such as pH, ionic strength, and the presence of organic and inorganic ligands. The adsorbed metals may leach back into the environment if the ambient conditions change. Live cells may, therefore, offer advantages in bioremediation [2]. Active and growing cells may incorporate the metals into vacuoles and other intracellular sites of the cells and the metals are not readily released back to the environment. Live cells may also exhibit selectivity towards certain metals or metal species. Literature methods for sorption study typically involve measurement of the bulk metal contents in the supernatant of the algae-metal solution mixture or the digested algae [6]. The required volume of the sample solution and/or the quantity of the algae are relatively large. Kinetics study is also limited by the multi-step sample treatment before measurement (i.e., centrifugation/filtration and/or digestion). The methods are inherently slow and are not adequate to follow fast events. Sophisticated methods such as electron microscopy (EM) and x-ray fluorescence microbeam analysis are available for the determination of metal distribution in a cell [7]. However, measurement of a large number of cells using the methods is inefficient. We plan to study the adsorption capacity and kinetics of heavy metals by live green algae using time-resolved inductively coupled plasma-mass spectrometry (ICP-MS). We will use Chlorella vulgris as a model. Chlorella vulgris is a type of small unicellar green algae, of diameter of approximately 10 micrometers. Aqueous solutions containing live cells of the algae will be rendered into a fine mist by conventional solution nebulization methods, such as pneumatic nebulization via a V-groove nebulizer. The cells are entrained individually in the solution aerosols if the number density of the algae in the original solution is sufficiently low. Our preliminary data show that cell number density of 10^6 /mL or below is adequate. The aerosols and the cells are readily transported to the ICP by a stream of argon carrier gas. As the cells enter the ICP individually, ions plumes corresponding to each cell are formed in the ICP. For sample solution of low algal cell number density, the plumes are separated from each other in the central channel of the ICP. The metal ions in each plume are readily detected using time-resolved ICP-MS as a current spike of duration of 100 microseconds [8]. The proposed method will be the first method to measure the metal content of individual algal cells with a relatively high sampling frequency of more than 10 cell/s. The time resolution for kinetics study of metal adsorption by the cells will be in the range of tens of seconds instead of minutes of the conventional bulk methods. Adsorption of metals onto the green algae can also be used as a preconcentration method of trace metals of concentration of part-per-trillion level. We have successfully used iron oxide nanoparticles and oxidized form of carbon nanotubes for metal preconcentration [8,9]. The preconcentrated metals on the particles are measured using time-resolved ICP-MS as current spikes. The signal-to-background ratios (SNR) of the current spikes are significantly larger than that of the bulk solution. The detection limits of metal determination are reduced. The adsorption capacity of Chlorella vulgris for heavy metals is large [1] and the size of the algae is relatively large compared to the nanoparticles (10 μm versus 100 nm). Chlorella vulgris is potentially a “super adsorbent” for trace metal preconcentration. Significant reduction in ICP-MS detection limits is expected. Preconcentration of metals by live cells may offer another advantage that the metals are taken up irreversibly [2] and the metals will not be lost from the cells by further treatment of the cells, e.g., filtration and washing. The objectives of the research proposal are summarized below. 1. To develop a rapid method for the determination of the metal sorption capacity and kinetics of green algae based on ICP-MS measurement of the quantity of heavy metals in individual algal cells. 2. To determine the feasibility of using algae as adsorbent particles for metal preconcentration for chemical analysis. Time-resolved measurement of the preconcentrated metals on individual cells may reduce the ICP-MS detection limits by orders of magnitude. References: 1. S.K. Mehta and J.P. Gaur, “Use of Algae for Removing Heavy Metal Ions from Wastewater: Progress and Prospects”, Critical Reviews in Biotechnology 2005, 25, 113-152. 2. A. Malik, “Metal bioremediation through growing cells”, Evironment International 2004, 30, 261-278. 3. R.H.S. Vieira and B. Volesky, “Biosorption: a solution to pollution?”, Internatl. Microbiol. 2000, 3, 17-24. 4. T.A. Davis, B. Volesky, and A. Mucci, “A review of the biochemistry of heavy metal biosorption by brown algae”, Water Research 2003, 37, 4311-4330. 5. F.A. Abu Al-Rub, M.H. El-Naas, F. Benyahia, and I. Ashour, “Biosorption of nickel on blank alginate beads, free and immobilized algal cells”, Process Biochemistry 2004, 39, 1767-1773. 6. S.K. Mehta and J.O. Gaur, “Concurrent sorption of Ni2+ and Cu2+ by Chlorella vulgaris from a binary metal solution”, Appl. Microbiol. Biotechnol. 2001, 55, 379-382. 7. “Bioremediation of metals and radionuclides”, 2nd edition (2003) by The National and Accelerated Bioremediation Research Program, Office of Biological and Environmental Research, Office of Science, US Department of Energy. http://www.lbnl.org/NABIR/generalinfo/primers_guides/03_NABIR_primer.pdf, accessed on November 15, 2006. 8. M.H.P. Yau and W.T. Chan, “A Novel Detection Scheme of Trace Elements Using ICP-MS”, J. Anal. At. Spectrom. 2005, 20, 1197-1202. 9. M.H.P. Yau, “Preconcentration of trace metals on nanoparticles for time-resolved ICP-MS measurement”, PhD thesis, The University of Hong Kong (2006).

 

List of Research Outputs

 

Hui Y.N., Lin B. and Chan W.T., On-line Preconcentration for Chip-based Capillary Electrophoresis - Inductivey Coupled Plasma Atomic Emission Spectrometry Using Continuous-flow Fled-amplified Sample Stacking , Abstract of Colloquim Spectroscopic um Internationale XXXV, Ximen, China, Septermber 23-27, 2007.

 

Tse B.L. and Chan W.T., Characterization of Bottom-viewed Inductively Coupled Plasma-atomic Emission Spectrometry (BV-ICP-AES), Abstract of Colloqium Spectroscopic um Internationale XXXV, Xiamen, China, September 23-27 . 2007.

 

Yau H.P.M., Lin B.C. and Chan W.T., On-line Preconcentration for Chip-based Capillary Electrophoresis - Inductivey Coupled Plasma Atomic Emission Spectrometry Using Continuous-flow Fled-amplified Sample Stacking, Colloquim Spectroscopicum Internationale XXXV, Xiamen, China, September 23-27, 2007. 2007.

 

Yau H.P.M. and Chan W.T., Preconcentration of Trace Metal Ions Using Freshwater Algae for Inductively Coupled Plasma -- Mass Spectrometry , Abstract of Conference (Poster Presentation) Colloquium Spectroscopic um Internationale XXXV, Xiamen, China, September 23-27, 2007.

 

Researcher : Chan YM



List of Research Outputs

 

Chan Y.M., The Chemistry and in Vitro Cytotoxicity Study of Managanese Oxide Nanostructres (PhD Thesis) . 2007.

 

Researcher : Chau DHW



List of Research Outputs

 

Li H.Y., Chau D.H.W., Gao Y., Ng S.M. and Lin M.C., Genome-wide Expression Profiling Reveals the Multiple Signaling Pathways Modulated by rAdv-hTERTC27 Treatment in Glioblastoma Multiforme, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Researcher : Che CM



Project Title:

Blue light photoluminescent materials

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

Hung Hing Ying Physical Sciences Research Fund

Start Date:

02/1999

 

Abstract:

To design and prepare highly robust and luminous materials for fabrication of bright blue-light emitting diode (LED) devices.

 

Project Title:

Institute of molecular technology for drug discovery and synthesis

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

Areas of Excellence Scheme

Start Date:

11/2001

 

Abstract:

To pursue world-class fundamental research in Chemical Biology; to develop novel compounds for new medicine and to engender the development of local and regional pharmaceutical industries through high quality research.

 

Project Title:

High-valent metal complexes and their photochemical studies

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

Matching Fund for NSFC Young Researcher Award

Start Date:

01/2002

 

Abstract:

To study high-valent metal complexes and their photochemical studies.

 

Project Title:

Shanghai-Hong Kong Joint Laboratory on chemical synthesis

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

University Research Committee / Committee on Research and Conference Grants - General Award

Start Date:

05/2002

 

Abstract:

To conduct research activties at Shanghai-Hong Kong Joint Laboratory on chemical synthesis

 

Project Title:

Research and development of luminescent biosensors for drug screening and environmental monitoring

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

11/2002

 

Abstract:

To optimize the luminescent materials developed by Che and co-workers for optical pH, oxygen and chlorinated hydrocarbons sensing technology; to fabricate optical biosensors using the newly developed luminescent materials; to apply the newly developed fluorescent pH/oxygen biosensors for cell viability assay, drug screening and monitoring of environmental pollutants.

 

Project Title:

Novel photoluminescent, sensory and photocatalytic materials derived from closed-shell metal ions and pi-conjugated organics: impact of weak intermolecular interactions and metal-functionalization upon photophysical and photochemical properties

Investigator(s):

Che CM, Lai SW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

The objective is to identify new 1-, 2- and 3- dimensional nanostructures of metal-capped oligomeric carbon materials with tunable spectroscopic properties and to develop novel applicantions in organic optoelectronics and sensory devices.

 

Project Title:

Functional nanomaterials research

Investigator(s):

Che CM, Chan MCW

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To develop new nanostructured and nanocomposite materials, based on the existing research expertise in synthetic chemistry, semiconductors, and ongoing collaborations with Chinese Academy of Sciences; to identify practical applications for newly prepared and patentable nanomaterials, such as catalysts for green chemistry and nanodevices for organic optoelectronics; to enable HKU to develop into a leading institution in nanosciences.

 

Project Title:

Metal-nitrogen multiple bonded complexes. Synthesis and applications in carbon-nitrogen bond formation reactions

Investigator(s):

Che CM, Tong SM, Chan PWH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To probe the mechanism of H atom abstraction and subsequent C-N bond formation by highly reactive metal-imido complexes; to develop non-porphyrin ruthenium catalysts including metal-metal bonded diruthenium systems for amidation of C-H bonds by the "PhI(OA)2 + RNH2 protocol; to prepare new classes of ruthenium and osmium-imido complexes other than those bearing tosylimido ligands; to explore and develop Fe catalysts containing strongly chelating polypyridine ligand systems for amidation of organic compounds; to study systematically the ruthenium-catalyzed amidation of C(sp2)-H bonds of aromatic hydrocarbons and develop its application in organic synthesis; to investigate systematically the proton-coupled electron transfer reactions of Ru-NH2R complexes by electrochemical means.

 

Project Title:

Functionalized phosphorescent metal-organic materials for biomedical, photocatalytic and organic optoelectronic applications

Investigator(s):

Che CM, Lai SW

Department:

Chemistry

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2005

 

Abstract:

To develop new classes of water-soluble phosphorescent metal-organic compounds and polymer derivatives, including those appended with polysaccharide groups, for practical applications in luminescent signaling and biomedical sciences; to develop robust polymer/matrix-supported copper(I) and platinum(II) photocatalysts for light-induced C-H bond activation and atom transfer radical addition polymerization reactions; to study the effect of π-conjugation between transition metal ions and carbon-rich organic materials upon their spectroscopic and excited-states characteristics; to develop new families of phosphorescent platinum(II) dendritic materials exhibiting tunable emission energies for organic optoelectronic applications; to prepare multinuclear Pt(II)-Ru(II) complexes which exhibit low-energy Ru(II)-to-Pt(II) and ligand-to-Pt(II) charge-transfer excited states and to study the electro-optical properties of these heterometallic compounds.

 

Project Title:

Photoluminescent properties and applications of luminescent d8 and d10 metal complexes with metal-metal interactions

Investigator(s):

Che CM

Department:

Chemistry

Source(s) of Funding:

Germany/Hong Kong Joint Research Scheme

Start Date:

01/2005

 

Abstract:

To exploit the photoluminescence, determined by weak meatllophilic interactions between metal ions with d8 or d10 electronic configuration, weak ligand-ligand interactions in phosphorescent organoplatinum(II) and organogold(I) complexes and intermolecular metal-ligand interactions of d8 and d10 metal species; to elucidate the electronic origin of the emission by spectroscopic methods; to apply the effects of weak interactions upon the emissive characteristics of phosphorescent metal-organic materials to the development of new operating principles for luminescent molecular sensors and nanodevices; to synthesize phosphorescent materials with potential applications in optoelectronics of OLEDs.

 

Project Title:

Strategic Theme on Drug Discovery and Synthesis

Investigator(s):

Che CM, Man RYK, Lau ASY, Li Y, Chen G

Department:

Chemistry

Source(s) of Funding:

Seed Funding for Strategic Research Theme

Start Date:

05/2005

 

Abstract:

To enhance collaborative interdisciplinary research between Science and Medicines with objectives to develop new drug leads and/or innovative research in biomedical sciences. To establish HKU as a leading centre in synergistic, interdisciplinary research on drug discovery and synthesis.

 

Project Title:

Metal-Carbon Multiple Bonded Complexes in Catalysis and Supramolecular Chemistry

Investigator(s):

Che CM, Wong MK

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2005

 

Abstract:

Due to the shortfall of budget, spectroscopic, electronic and energy transfer studies of metal-carbon multiple bonded compounds could not be covered. The revised components of study include the followings: [1] reactive metal-carbene/alkylidyene complexes particularly the bis(carbene/alkylidene)osmium and high-valent ruthenium alkylidene complexes, [2] carbenoid transfer reactions in aqueous medium, and [3] design and synthesis of new classes of polymeric metal-containing carbon-rich materials.

 

Project Title:

Development of Ruthenium and Iron Catalysts for Green and Biological Oxidations

Investigator(s):

Che CM, Wong MK

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2006

 

Abstract:

Oxidation Chemistry plays a pivotal role in biological processes and fine chemical industries, and the development of efficient, selective and environmentally friendly oxidation technologies remains a significant challenge in Chemical Sciences in the forthcoming decades. Metal-catalyzed oxidation reactions that utilizes air or hydrogen peroxide as a terminal oxidant is an area of great interest. In this context, there is a continued and growing interest in the design of oxidatively robust catalysts of ruthenium and iron. High-valent ruthenium- and iron-oxo complexes are widely known to have rich oxidation chemistry but applications of their oxidation chemistry in practical organic synthesis have yet to be achieved. Over the years, we have extensively developed metalloporphyrins as efficient catalysts in oxidation reactions. By virtue of the structural diversity of the macrocyclic ligand, steric and electronic properties of metalloporphyrin catalysts can be fine-tuned for stereo- and enantioselective oxidation reactions. We envisage that metalloporphyrins would have tremendous potential to be the future catalysts of choice for selective oxidation reactions in Chemical Industries. Recently, we have developed a practical and mild method for highly selective conversion of terminal alkenes to aldehydes catalyzed by ruthenium porphyrins. More interestingly, we have discovered that this Wacker type oxidation of alkenes can be conducted using air as oxidant. Apart from metalloporphyrin-based catalysts, we have recently prepared a series of iron(II) oligopyridyl complexes, which have been characterized by X-ray crystallography. We are delighted to find that these iron complexes are highly efficient catalysts for alkene epoxidation using Oxone as a terminal oxidant. The main objective of this project is to develop new classes of ruthenium- and iron-oxo complexes for catalytic organic oxidations using air, hydrogen peroxide or Oxone as a terminal oxidant with special emphasis to address several important problems in organic oxidations. The deliverables of this project include a collection of new oxidatively robust catalysts, application studies of ruthenium-catalyzed aerobic Wacker type oxidation of alkenes to aldehydes and iron-catalyzed selective alkene epoxidation and biological oxidation. The ultimate goal is to develop efficient and green oxidation reactions that have useful applications in practical organic synthesis and fine chemical industries.

 

Project Title:

Reactive metal-oxo complexes of group VIII metals for organic oxidations

Investigator(s):

Che CM, Wong MK, Tong SM

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

This project aims to establish an interdisciplinary research program to expand the scope of research in metal-catalyzed organic oxidations previously developed in the laboratories [The University of Hong Kong and Shanghai-Hong Kong Joint Laboratory on Chemical Synthesis] of the HKU team. Synergetic efforts would be made to employ metalloporphyrins as key catalysts in organic synthesis, develop practical iron catalysts for organic oxidations, the latter is an area receiving a rapidly growing attention after the recent works of Que and co-workers (Science, 2003, 299, 1037), development of alternative and inexpensive catalysts for cis-dihydroxylation of alkenes and green oxidation catalysis. In essence, the objectives include. (1) To develop metalloporphyrin-catalyzed alkyne oxidations for biomolecule modification and practical protocols for construction of synthetically useful epoxides using environmentally friendly oxidants. (2) To develop ruthenium-catalyzed organic oxidations using air or hydrogen peroxide as a terminal oxidant. Of particular interest is to develop the chemistry of ruthenium-catalyzed Wacker oxidation of alkenes to aldehydes recently discovered at Shanghai-Hong Kong Joint Laboratory on Chemical Synthesis. (3) To develop practical iron catalysts using oligopyridine ligand systems for organic oxidations. (4) To design new classes of ruthenium-oxo complexes including those containing chiral auxiliary ligands for cis-dihydroxylation of alkenes. This work also aims to inquire as to whether a cis-dioxometal unit is a necessary requisite to accomplish cis-dihydroxylation of alkenes. (5) To examine the chemistry and reactivities of hitherto unknown reactive oxo complexes of ruthenium and iron using density functional theory calculations, and to systematically compare the ligand[pp(O2-)]-to-metal charge-transfer excited states of iron, ruthenium and osmium possessing the same dn electronic configuration. (6) To develop supported metal catalysts including those containing ruthenium nanoparticles for organic oxidations. This project is a concerted effort to tackle some difficult problems in the field of organic oxidations. Completion of this project could lead to important findings in ruthenium-catalyzed organic oxidations using air or hydrogen peroxide as a terminal oxidant. The outcomes would be rewarding as inexpensive and green oxidation technologies for fine chemical industry and organic synthesis could be developed. The development of practical and robust iron-based catalysts for organic oxidations with high selectivity and product turnovers is likely to have a long lasting impact in the forthcoming decade.

 

Project Title:

Atom and Group Transfer Reactions for Carbon-Nitrogen Bond Formation

Investigator(s):

Che CM, Ho CM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

Nitrogen atom insertion to saturated C-H bonds catalyzed by transition metal complexes provides a convenient synthetic route to amine and amine derivatives, which are important intermediates generally used for the synthesis of pharmaceuticals and bioactive natural products. Metal complexes of Rh(II) and Ru(II) are effective catalysts for inter- and intramolecular amidation of saturated C-H bonds and aziridination of alkenes with PhI=NTs as a nitrogen source. However, these processes involve the usage of the highly toxic and expensive late transition metal catalysts and halogenated organic solvents. In this connection, it continues to be a challenge for chemists to develop new green catalysts (such as Fe) that can reduce the use of highly toxic metal catalyst, and achieve high product turnovers amidation reactions. Over the years, we have extensively investigated high-valent ruthenium- and osmium-ligand multiple bonded complexes in catalytic atom/group transfer reactions (over 250 papers and reviews published in international chemistry journals). By virtue of the structural diversity of the auxiliary ligands, the steric and electronic properties of transition metal catalysts can be tuned for stereo- and enantioselective reactions. For example, we showed that formation of sulfamte esters and carbamates can be achieved in high yields and e.e. values using chiral Ru(II) porphyrin catalysts [Che et al, Angew. Chem. Int. Ed. 2002, 41, 3465]. On the other hand, little is known about the high-valent iron-nitrogen multiple bonded complexes. High-valent iron-imido complexes are usually proposed to be the reactive intermediates in Fe-porphyrin catalyzed amidation of hydrocarbons. Very recently, Berry et al reported the isolation and characterization of the first octahedral Fe(VI)-nitrido complexes [Science 2006, 312, 1937]. Our recent studies showed that reaction of [Fe(py5)(CH3CN)]2+ with PhI=NTs in MeCN produced a rapid color change and a yellow solid was obtained after evaporation to dryness. ESI mass spectral analysis revealed a molecular ion peak at m/z = 612, tentatively assigned to [TsN=Fe(py5)]+. Recently, we have determined the X-ray crystal structures of two bis(tosylimido)ruthenium(VI) porphyrin complexes and revealed that the Ru-N(imido) distances depended on the para-substituent on the phenyl ring of the tosylimido ligand. We envisage that iron catalyst would have tremedous potential to be the future catalysts of choice for selective amidation of hydrocarbons. We have found that [Fe(Cl3terpy)2]2+ is an active catalyst for aziridination of alkenes and amidation of activated C-H bond with moderate to good product yields. We propose to extensively develop such chemistry, including isolation of the Fe=NTs species for X-ray and spectroscopic characterization and reactivity studies. With our existing research capability and promising findings, we aim (1) to explore and develop new class of Fe catalysts containing chelating polypyridine ligand systems for selective amidation of organic compounds, (2) to synthesize and characterize the high-valent iron-imido compounds, (3) to probe the mechanism of C-H insertion and subsequent C-N bond formation by highly reactive metal-imido complexes, and (4) to prepare and/or generate cis-oxo-imido metal complexes for aminohydroxylation of C=C bonds and to develop robust metal catalysts for this transformation.

 

List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Che C.M., Kwok C.C., Lai S.W., Finkenzeller W., Rausch A., Yersin H. and Zhu N., Synthesis, Photophysical Properties and OLED Applications of Luminescent Platinum(II) Schiff Base Emitters, The First Asian Conference on Coordination Chemistry, Okazaki, Japan, 29 July - 2 Aug. 2007.

 

Che C.M. and Huang J.S., 活性钌、锇-配体多重键配合物研究进展, 中国科学B:化学, 2008, 38: 365-395.

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Cheung O.F.S., Wong K.K.Y., Ho C.M., Che C.M. and Tam P.K.H., The anti-inflammatory properties of nanosilver , The 12th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 12 - 14 December 2007.

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Deng Q., Xu H.W., Yuen A.W.H., Xu Z.J. and Che C.M., Ruthenium-Catalyzed One-Pot Carbenoid N-H Insertion Reactions and Diastereoselective Synthesis of Prolines , Organic Letters. 2008, 10: 1529-1532.

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., 234th ACS National Meeting. 2007, Poly-319.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., Polymer Preprints (American Chemical Society, Divison of Polymer Chemistry). 2007, 48: 589 - 590.

 

Lai S.W., Chan K.W.Q., Zhu N. and Che C.M., cis-Dicyanoosmium(II) Diimine Complexes Bearing Phosphine or Sulfoxide Ligands: Spectroscopic and Luminescent Studies, Inorganic Chemistry. Washington, D.C., American Chemical Society, 2007, 46: 11003-11016.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Lin X., Zhao C., Che C.M., Ke Z.F. and Phillips D.L., A DFT Study on the Mechanism of Rh2(II,II)-Catalyzed Intramolecular Amidation of Carbamates , Chemistry - An Asian Journal . 2007, 2: 1101-1108.

 

Lin X., Che C.M. and Phillips D.L., Reaction Mechanism and Stereoselectivity of Ruthenium--Porphyrin-Catalyzed Intramolecular Amidation of Sufamate Ester: A DFT Computational Study , Journal of Organic Chemistry. 2008, 73: 529-537.

 

Liu X. and Che C.M., A Highly Efficient and Selective AuI-Catalyzed Tandem Synthesis of Diversely Substituted Pyrrolo[1,2-a] Quinolines in Aqueous Media , Angewandte Chemie International Edition. 2008, 47: 3805-3810.

 

Liu Y., Zuo J.L., Che C.M. and Li Y.Z., Synthesis and Characterization of a Two-dimensional Manganese Coordination Polymer , 一個錳的二維配位聚合物的合成及其物質, Chinese journal of Inorganic Chemistry . 無機化學學報, 2008, 24: 610-614.

 

Liu Y., Xiao W., Wong M.K. and Che C.M., Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin , Organic Letters. 2007, 9: 4107-4110.

 

Lo K.Y., Wong M.K. and Che C.M., Gold-Catalyzed Highly Enantioselective Synthesis of Axially Chira Alenes , Organic Letters. 2008, 10: 517-519.

 

Lok C.N., Ho C.M., Chen R., Tam P.K.H., Chiu J. and Che C.M., Proteomic identification of the Cus system as a major determinant of constitutive escherichia coli silver resistance of chromosomal origin, Journal of Proteome Research. 2008, 7: 2351-2356.

 

Lu L., Sun R.W., Chen R., Hui C.K., Ho C.M., Luk J.M.C., Lau G. and Che C.M., Silver nanoparticles inhibit hepatitis B virus replication, Antivir. Ther.. 2008, 13(2): 253-262.

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Lu W., Chui S.Y., Ng K.M. and Che C.M., A Submicrometer Wire-to-Wheel Metamorphism of Hybrid Tridentate Cyclometalated Platinum(II) Complexes, Angewandte Chemie International Edition. 2008, 47: 4568.

 

Stallinga P., Vellaisamy A.L.R., Xu Z., Xiang H. and Che C.M., Metal-Insulator-Meta Transistors , Advanced Materials. 2008, 20: 2120-2124.

 

Sun R.W.Y., Ma D.L., Wong E.L.M. and Che C.M., Some Uses of Transition Metal Complexes as Anti-cancer and Anti-HIV Agents , Dalton Transactions. 2008, 4884-4892.

 

Tang H.W., Ng K.M., Liang Z.T., Che C.M., Cheng Y.C. and Zhao Z.Z., Histochemical Analysis of Medicinal Plants by Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry, 6th Meeting of Consortium for Globalization of Chinese Medicine, Beijing, China. 2007.

 

Tang H.W., Ng K.M. and Che C.M., Internal Energy Transfer in Carbon-based Surface-Assisted Laser Desorption/Ionization: Graphite versus Diamond, The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Colorado Convention Center, Denver, Colorado, U.S.A.. 2008, ThP085.

 

Tang W.M., Cheng K.H., Leung C.H., Lai P.T., Xu J. and Che C.M., Improved Performance for OTFT with HfTiO2 as gate dielectric by N2O annealing, Proceedings of IEEE International Conference on EDSSC. Tainan, 2007, 189-192.

 

Tong S.M., Wong E.L.M. and Che C.M., Density Functional Theory Study of trans-Dioxo Complexes of Iron, Ruthenium, and Osmium with Saturated Amine Ligands, trans-[M(O)2(NH3)2(NMeH2)2]2+ (M=Fe, Ru, Os), and Detection of [Fe(qpy)(O)2]n+ (n=1, 2) by High-Resolution ESI Mass Spectrometry, Chemistry - A European Journal. 2008, 14: 5495-5506.

 

Vellaisamy A.L.R., Wong E.L.M., Ko B.C.B., Chao C.T., Yan S.C., Yan B., Wu J.C. and Che C.M., Ambipolar Charge Transport in DNA Molecules, Advanced Materials. Wiley InterScience, 2008, 20: 1258-1262.

 

Wang Y., Che C.M., Chiu J. and He Q.Y., Dioscin (Saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: A proteomic-based study, Journal of Proteome Research. 2007, 6: 4703-4710.

 

Wang Y., He Q.Y., Che C.M., Tsao G.S.W., Sun R.W.Y. and Chiu J., Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways, Biochemical Pharmacology. 2008, 75: 1282-1291.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Xiang H., Lai S.W., Lai P.T. and Che C.M., Phosphorescent Platinum(II) Materials for OLED Applications, In: Hartmut Yersin, Highly Efficient OLEDs with Phosphorescent Materials. John Wiley & Sons (Asia) Pte. Ltd., 2007.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Che C.M., Lai P.T., Zeng P.J., Niu F.F., Liu Y.W., Tang W.Q., He C.J. and Niu H.B., Star-configured Carbazole as an Efficient Near-ultraviolet Emitter and Hole-transporting Material for Organic Light-emitting Devices , Applied Physics Letters. 2008, 92: 073305-1 to 073305-3.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Yip W.P., Yip W.P., Ho C.M., Zhu N., Lau T.C. and Che C.M., Homogeneous [RuIII(Me3tacn)Cl3]-Catalyzed Alkene cis-Dihydroxylation with Aqueous Hydrogen Peroxide , Chemistry - An Asian Journal. 2008, 70-77.

 

Researcher : Chen B



List of Research Outputs

 

Geng Z., Chen B. and Chiu P., The University Research Output Prize 2006-2007, The HKU University Research Committee, Hong Kong . 2007.

 

Researcher : Chen F



List of Research Outputs

 

Chen F., Song K., Wu Y.D. and Yang D., Synthesis and Conformational Studies of g-Aminoxy Peptides , Journal of the American Chemical Society. 2008, 130: 743-755.

 

Researcher : Chen G



Project Title:

A first-principles method for calculating STM images of nanoscale molecular systems and its application to alkyl substituted phthalocyanines and porphyrins

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2002

 

Abstract:

The objective of the project is to develop an efficient first-principles method to calculate the scanning tunneling microscopy (STM) images of nonoscale molecular systems and thus build an important tool in the reearch and development of nanotechnology.

 

Project Title:

First-principles quantum mechanical methods as predictive tools in materials design: neural networks approach

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2004

 

Abstract:

To employ Neural-Networks-based algorithms to improve greatly the accuracies of the first-principles quantum mechanical methods; to reduce the numerical errors within 1 to 2 kcal/ mol, i.e. the chemical accuracy; to combine the artificial intelligence and the first-principles quantum mechanical methods; to have profound impacts to computational chemistry and physics; to pave the way for the first-principles quantum mechanical methods to be employed as practical tools in materials design and research.

 

Project Title:

Theoretical Investigation and Computer Simulation of Carbon-Nanotube-Based Devices: Gigahertz Oscillators, Field Emitters and Tweezers

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To explore potential electric and mechanical applications of CNTs; to design new types of nanomechanical devices as operative tools for manipulating atoms and molecules; to contribute to the advancements of nanoscopic science and technology.

 

Project Title:

Efficient linear scaling methods for optical properties of nanoscale material systems

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Germany/Hong Kong Joint Research Scheme

Start Date:

01/2005

 

Abstract:

To develop linear-scaling quantum mechanical methods to simulate complex molecular systems such as nanotubes, nanowires, polymer films, surface, interfaces and biological molecules; to apply the resulting methods to examine the charge transport, optical and magnetic properties of nanotubes and nanowires and the photophysical processes in biological molecules.

 

Project Title:

Theoretical investigation of Zinc Oxide nanobelts and nanodevices

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

06/2005

 

Abstract:

In this project, first-principles quantum mechanics and molecule mechanics methods will be employed to calculate the electronic structures of ZnO nanobelts and to help understand the structural basis of the unique physical properties of ZnO belts. The findings are expected to provide the useful guidance for ZnO nanobelts as potential constituents of nanodevices.

 

Project Title:

Theoretical investigation of carbon-nanotube-based nanoelectromechanical systems

Investigator(s):

Chen G, Zhao Y

Department:

Chemistry

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

12/2005

 

Abstract:

To understand physical properties of the CNT-based nano-components, to design and simulate novel CNT-based NEMS devices and to examine NEMS thermodynamic behavior and fundamental laws of statistical mechanics and thermodynamics at nanoscopic scales.

 

Project Title:

A novel numerical algorithm for prediction of 3D protein structures

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2006

 

Abstract:

The proposed work is to help resolve an important open question in life science, the prediction of protein three-dimensional structures. Due to recent developments in masspec and various sequencing technolgies, the determination of the primary sequences od proteins is not as difficult as before. However, determining their three-dimensional structures remains a challenge. Our objective is to develop a novel numerical algorithm to predict the three dimensional structures of proteins. An emerging view holds that protein folding is determined by the characristic kinetics of protein dynamics. The initial step of protein folding is the formation of secondary structures. This occurs within nano-seconds and is then followed by a hydrophobic collapse of proteins to their globular structures. The time scale of the hydrophobic collapse is from nano-seconds to micro-seconds. Finally, the globular structures re-adjust themselves, which may take more than seconds. Our proposed numerical algorithm is based on this emerging view of protein folding. The first step of our calculation is to determine the secondary structures from the primary sequence via homology modeling. Homology modeling has been employed to predict the tertiary structures of proteins. Due to the limited available known protein structures, homology modeling has only been applied successfully to small number of proteins. On the other hand, there are enough data on secondary structures that can be used for prediction of almost any secondary structures from the primary sequences. Homology modeling of secondary structures is thus expected to be highly successful. The second step of our calculation is to determine the globular structures. This can be achieved by a number of approaches, for instance, fixing the secondary structures while carrying our molecular dynamics simulations, or simplifying the interactions within the proteins by hydrophobic and hydrophillic interactions only. With such approaches, the degrees of freedom are reduced drastically, and thus it would be straight forward to predict the globular structures due to hydrophobic collapsing. Final step of our calculation is annealing which can be carried out by molecular dynamics simulation. Besides developing the algorithm, we plan to develop a computer program as well. The resulting program reads the primary sequence of any protein and predicts several three-dimensional structures of the protein. Each predicted structure carries a confidence score. It is our expectation that our program will become one of the standard programs that researchers will use to predict or interpret the tertiary structures of proteins in a near future.

 

Project Title:

Towards the chemical accuracy: Combining first-principles methods and Neural Networks

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

In the proposed research, we develop the highly accurate first-principles quantum mechanical methods that systematically correct these inherent errors and thus yield the results of chemical accuracy. It is our objective that the resulting methods are quantitatively accurate and can be employed routinely as predict tools in chemistry, condensed matter physics, and materials science and engineering.

 

Project Title:

First-principles simulation of dynamic responses of molecular and nanoscopic devices

Investigator(s):

Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

(1) The main objective of the proposed project is to investigate the dynamic electric responses of molecular and nanoscopic devices via computer simulation. While first-principles calculations have been carried out to study the steady currents through these electronic devices, such calculations have not been performed to simulate the transient responses of these devices. We intend to simulate in real time the evolution of electronic density distribution throughout these devices upon the application of external field. The devices of our particular interests are fullerene-based field effect transistors. (2) Another major objective is to develop a highly accurate and efficient first-principles method for such real time simulations. Real time computer simulation of molecular and nanoscopic devices is a difficult challenge. Accuracy, reliability and efficiency are all required for a successful numerical calculation. To achieve this, we need to develop an entirely new first-principles method. While they have been remarkably successful, the applications of first-principles quantum mechanical methods have been limited to isolated systems where the number of electrons and energy are conserved. However, most physical, chemical and biological systems are open systems where energy as well as matter are being exchanged between the system and the surrounding. Traditionally quantum dissipation theory (QDT) has been used to study open systems. Because of the enormous computational tasks that are required, conventional numerical methods based on QDT are limited to the small model systems. Our proposed first-principles quantum mechanical method solves the time-evolution of reduced single-electron density matrix instead of many-body wavefunction or system density matrix, and thus requires far less computational time. The resulting formulism is expected to be rigorous. (3) Building upon the results of our numerical simulations on fullerene based electronic devices, we intend to propose new novel devices for further investigations and applications. The techniques and experiences that we acquire through this project can be applied to study nano-devices and other open systems. The success of our project should provide timely the new understandings for molecular- and nano-electronics.

 

List of Research Outputs

 

Chen G., “Linear-scaling time-dependent density-functional theory”, CECAM Workshop on Linear-scaling mehods, Lyon, France. 2007.

 

Chen G., “Time-dependent density-functional theory for open systems and its calculation of transient current through molecular devices”, 234th American Chemical Society National Meeting, Boston, USA. 2007.

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Pang H.F., Ye J., Leung W.H., Chen G. and Cheung A.S.C., Experimental and Theoretical Studies of Diatomic Iridium Compounds , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16,. 2008, MF12.

 

Wang F., Yam C.Y., Chen G., Wang X.J. and Fan K.N., Linear Scaling Time-dependent Density-functional Thight-binding Method for Absorption Spectra of Large Systems , Physical Review B. 2007, 76: 045114-1 - 045114-6.

 

Wang X.H., Xin H., Leonard J.N., Chen G. and Jiang Q., Ultra-fast Oscillation of Cobalt Clusters Encapsulated Inside Carbon Nanotubes , Nanotechnology. 2007, 18: 445703-1 ~ 445703-7.

 

Xu Z.P., Zheng Q.S., Jiang Q., Ma C.C., Zhao Y., Chen G. and Gao H., Trans-phonon Effects in Ultra-fast Nanodevices , Nanotechnology. 2008, 19: 255705-1 - 255705-5.

 

Researcher : Chen Q



List of Research Outputs

 

Chen Q. and Fung Y.S., Quantum Dots for Detection of Organophosphorus Pesticides , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:60, pp 5:145.

 

Researcher : Chen R



List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Lok C.N., Ho C.M., Chen R., Tam P.K.H., Chiu J. and Che C.M., Proteomic identification of the Cus system as a major determinant of constitutive escherichia coli silver resistance of chromosomal origin, Journal of Proteome Research. 2008, 7: 2351-2356.

 

Researcher : Chen W



List of Research Outputs

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Researcher : Chen X



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Researcher : Chen Z



List of Research Outputs

 

Li M., Chen Z., Zhu N., Yam V.W.W. and Zu Y., Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cations Binding , Inorganic Chemistry. 2008, 1218-1223.

 

Li M., Chen Z., Yam V.W.W. and Zu Y., Multifunctional Ruthenium (II) Polypyridine Complex-Based Core-Shell Magnetic Silica Nanocomposites: Magnetism, Luminescence, and Electrochemiluminescence , ACS Nano. 2008, 2: 905-912.

 

Researcher : Cheng CC



List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Lam S.W.H., Cheng C.C. and Yam V.W.W., Computational Studies on the Photophysical Properties and NMR Fluxionality of the Tetranuclear Copper(I) Complexes [Cu4(m-dppm)(m4-E]2+(E= PPh and S) , 234th ACS Meeting . 2007, INOR-733.

 

Yu S.Y., Sun Q.F., Lee K.M., Cheng C.C., Li Y.Z. and Yam V.W.W., Au36 Crown: A Macrocyclization Directed by Metal-Metal Bonding Interactions , Angewandte Chemie International Edition. 2008, 47: 4551-4554.

 

Researcher : Cheng KH



List of Research Outputs

 

Tang W.M., Cheng K.H., Leung C.H., Lai P.T., Xu J. and Che C.M., Improved Performance for OTFT with HfTiO2 as gate dielectric by N2O annealing, Proceedings of IEEE International Conference on EDSSC. Tainan, 2007, 189-192.

 

Researcher : Cheng KW



List of Research Outputs

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Cheng K.W., Polymers with Pendant Transition Metal Complexes for Photovoltaic Applications and Nanofabrications (PhD Thesis) . 2008.

 

Cheng K.W., Mak S.K., Chan W.K., Ng M.C.A. and Djurisic A., Synthesis of conjugated polymers with pendant ruthenium terpyridine trithiocyanato complexes and their applications in heterojunction photovoltaic cells, Journal of Polymer Science: Part A: Polymer Chemistry. Wiley Periodicals, Inc., 2008, 46: 1305-1317.

 

Ng M.C.A., Djurisic A., Tam K.H., Cheng K.W., Chan W.K., Tam H.L., Cheah K.W., Lu A.W., Chan J. and Rakić A.D., 3,4,9,10-Perylenetetracarboxylicdiimide as an interlayer for ultraviolet organic light emitting diodes, Optics Communications. Amsterdam, Elsevier B.V., 2008, 281: 2498-2503.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Tse C.W., Cheng K.W. and Chan W.K., Synthesis of Hyperbranched Polymers with Rhenium(I) Bis(Stilbazoylimino)Acephthalene Complexes at the Branching Units, Journal of Inorganic and Organometallic Polymers and Materials. Springer Science, 2007, 18: 59-68.

 

Researcher : Cheng KW



List of Research Outputs

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Cheng K.W., Polymers with Pendant Transition Metal Complexes for Photovoltaic Applications and Nanofabrications (PhD Thesis) . 2008.

 

Cheng K.W., Mak S.K., Chan W.K., Ng M.C.A. and Djurisic A., Synthesis of conjugated polymers with pendant ruthenium terpyridine trithiocyanato complexes and their applications in heterojunction photovoltaic cells, Journal of Polymer Science: Part A: Polymer Chemistry. Wiley Periodicals, Inc., 2008, 46: 1305-1317.

 

Ng M.C.A., Djurisic A., Tam K.H., Cheng K.W., Chan W.K., Tam H.L., Cheah K.W., Lu A.W., Chan J. and Rakić A.D., 3,4,9,10-Perylenetetracarboxylicdiimide as an interlayer for ultraviolet organic light emitting diodes, Optics Communications. Amsterdam, Elsevier B.V., 2008, 281: 2498-2503.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Tse C.W., Cheng K.W. and Chan W.K., Synthesis of Hyperbranched Polymers with Rhenium(I) Bis(Stilbazoylimino)Acephthalene Complexes at the Branching Units, Journal of Inorganic and Organometallic Polymers and Materials. Springer Science, 2007, 18: 59-68.

 

Researcher : Cheung ASC



Project Title:

Laser Jet Spectroscopy of Low-lying Electronic States of Group III-V Diatomic Molecules

Investigator(s):

Cheung ASC

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2004

 

Abstract:

To record the electronic transition spectrum of some selected gas-phase Group III-V diatomic molecules in the visible and NIR spectral regions; to analyze the electronic transition spectrum recorded for some-selected Group III-V diatomic molecules and determine their molecular structure. Reasons for the change: the change from covering the UV. visible and NIR spectral regions of the Group III-V diatomic molecules to only the visible and NIR regions of some selected Group III-V diatomic molecules is necessary because, at the present funding level, resource is insufficient for us to tackle the whole spectral region and most of the Group III-V molecules as proposed.

 

Project Title:

Laser spectroscopy of metallic compounds in a pulsed plasma expansion

Investigator(s):

Cheung ASC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2006

 

Abstract:

The objective of this investigation is to study the low-lying electronic transitions of metal compounds. It is proposed to combine direct current (DC) discharge and free jet expansion source for producing the metal compounds in gas-phase and using cavity ring down (CRD) spectroscopy to study electronic transitions in the near infrared spectral region. The goal of this research is to determine the molecular vibrational and rotational constants for electronic transitions of metal compounds. The electronic transition spectrum of gas-phase metal compounds is a topic of great interest in many branches of chemistry and physics [1]. Bonding between a ligand is of great importance in chemistry because of the role it plays in homogenous and heterogeneous catalytic processes [2]. In addition, metal compounds have been found in the circumstellar envelops of M-type stars, making these species of interest to the astrophysical community as well [3,4,5]. Searching and detection of gas-phase of metal compounds in stellar objects rely heavily on laboratory measurements of their electronic transition or rotational spectrum for identifying particular transition frequencies to aid the search. Unfortunately, transition frequencies for these carbide molecules are generally not available. We hope to be able to provide such transition information for the astronomy community to search for them. Detection of any of the metallic diatomic molecules would have broad implication for nucleosynthesis, dust grain composition and gas-phase chemistry in circumstellar materials Many metal compounds are high temperature molecules and their production usually require high temperature environment. The usual hot oven technique presents difficulties in the vaporization of these high temperature compounds. Even though thermal excitation could produce these metal compounds in gas phase, the thermal distribution of these molecules at high temperature will greatly complicate the absorption or emission spectra obtained. Supersonic expansion is a well-known technique for cooling the internal degrees of freedom of molecules far below the normal boiling point, while maintaining the molecules in gas phase. Recently, this method has been combined with laser vaporization/reaction source to produce high boiling transition metal compounds [6,7]. High voltage direct-current (DC) pulsed discharge has also proven to be a versatile technique in producing carbon-containing molecules [8,9]. Early work in DC pulsed discharge indicated that the production of molecular species and production efficiency is extremely sensitive to the discharge voltage applied, discharge timing, the compositions of sample gas and so on. It is possible to generate different species under various conditions [8]. We plan to build a DC pulsed discharge assembly in this project at the exit of the free jet expansion molecular source. The cavity ring down spectroscopy (CRDS), using pulsed tunable lasers, has proven to be a highly sensitive absorption technique. Since its introduction [10], CRDS has resulted in applications to chemical problems ranging from surface phenomena to process measurements in plasmas and plumes, to atmospheric studies and to a wide range of chemical kinetics studies. This novel type of long path-length measurement is based upon the measurement of the rate of absorption rather than the magnitude of absorption of a light pulse confined within a closed cell cavity. By measuring the decay time, this technique overcomes known stability and intensity variation problems encountered with pulse lasers. CRDS is one of the most sensitive absorption techniques presently available. Studies of various reaction intermediates and products using CRDS have been reported in a review by Busch and Busch [11]. Even thought laser-induced fluorescence (LIF) spectroscopy is one the most sensitive laser spectroscopic technique available for studying electronic transition, but in the NIR region LIF is not that useful because of the lack of very sensitive detector. The advantage of the CRDS using multi-pass absorption technique in the NIR spectral region is obvious. In this project, electronic transition spectrum of metal compounds in the NIR will be recorded using CRDS. References: [1] J. F. Harrison, Chem. Rev. 100, 679 (2000). [2] W.A. Nugebt and J.M. Mayer, “Metal Ligand Multiple Bonds”, Wiley-Interscience, New York, 1988. [3] M.A. Brewster and L.M. Ziurys, Astrophys. J. Lett. 559, L163, (2001). [4] G. van Helden, A.G. Tielens, M.A. Duncan, L.B. Waters,and G. Meijer, Science 288, 313 (2000) [5] R.R. Joyce, K.H. Hinkle, L. Wallace, M. Dulick and D.L. Lambert, Astrophys. J. 116, 2520 (1998). [6] S. Maruyama, L.R. Suderson, R.E. Smalley, Rev. Sci. Instrum., 61, 3686 (1990). [7] A. S-C. Cheung, Q. Ran, W.S Tam, D. K-W. Mok, P.M. Yeung, J. Mol. Spectrosc. 203, 96 (2000). [8] Y. Ohshima and Y. Endo, J. Mol. Spectrosc. 153, 627 (1992) [9] T.C. Smith, H. Li, D.J. Clouthier C.T, Kingston and A.J. Merer, J. Chem. Phys.112, 3663 (2000) [10] J. J. Scherer, J. B. Paul, A. O’Keefe and R. J. Saykally, Chem. Rev, 97, 25 (1997). [11] K. W. Busch and M. A. Busch, Cavity Ring Down Spectroscopy ACS series 720, ACS, Washington. DC. USA, 1999.

 

Project Title:

Electronic transition spectrum of transition metal carbides

Investigator(s):

Cheung ASC

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

(1) The purposes of the investigation are: (i) To produce gas-phase transition metal (TM) carbides using the state-of-the-art laser vaporization/reaction and/or high voltage direct-current pulsed discharge followed by supersonic cooling techniques. Such a combination of laser vaporization and discharge techniques is new for producing metal compounds. (ii) To record and analyze the near infrared spectra of TM carbides using cavity ring down spectroscopy. Electronic transitions of the carbide molecules, particularly the early 3d period: TiC, VC and CrC, have not been observed so far. Our work could provide first experimental spectroscopic observation of these TM carbides. (iii) To study and understand the electronic structure of these carbides using molecular orbital theory and compare their electronic structure across the entire first transition metal period. (2) The impact and significance of these experiments are: (i) These experiments provide high quality data on the spectroscopic properties of the electronic states of TM carbides. The information obtainable concerns molecular and electronic structure. When the metal nucleus possesses non-zero nuclear spin, hyperfine interactions between the nucleus and the unpaired electron produce further splitting of the rovibronic energy levels. These interactions are extremely sensitive probes of the electronic structure and are very stringent test of the theory of chemical bonding. (ii) In this project, the first row transition metal carbides are of interest. These molecules have many unpaired electrons in their molecular orbital giving rise to high spin multiplicity states. It is hoped that starting from simple carbides and proceeding gradually to more complicated systems, this will help to build up our knowledge in large metal carbide systems. (iii) The observed transition frequencies in the near infrared region will be extremely useful and significant for astronomers to search for these TM carbides in the stellar objects. (3 ) Possible outcome: (i) First experimental observation of the electronic transition spectra of the early 3d period TM carbides: TiC, VC and CrC molecules. Accurate determination of molecular constants and provide understanding of the electronic structure of the TM carbides. (ii) Detailed comparison of the chemical bonding of the first row transition metal carbides using the molecular orbital theory. (iii) Data obtained could facilitate the search of these molecules in stellar object such as low temperature carbon rich stars.

 

Project Title:

Laser spectroscopy of metal borides

Investigator(s):

Cheung ASC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

The objective of this investigation is to study the electronic spectra of gas-phase metal boride molecules in the visible and near infrared (560 – 1000nm) regions using laser vaporization/reaction free jet expansion technique and laser induced fluorescence spectroscopy, and to determine molecular vibrational and rotational constants for electronic transition of metal boride. The electronic structure of metal borides is a topic of great interest in many branches of chemistry [1]. Many metal brides such as CoB2, Ni3B, FeB etc. are good catalysts for hydrogenation of alkenes and also deoxygenation reactions of sulfoxides. Recently, magensium boride was found to have superconducting property at 39K [2]. These compounds show a wide range of crystal structures and often differs greatly from one another in their physical and chemical properties. Bond type is often uncertain. These borides frequently exhibit properties different to those metal carbides and nitides. Despite the importance of the metal borides, only very limited information on the structure of these compounds has emerged from studies which have been pursued so far. A detailed understanding of the molecular electronic structures can be derived from the study of gas-phase molecular spectra. These metal borides are very hard, high melting, refractory molecules whose structures and stoichiometries do not conform to the ordinary concepts of valence. Borides with low boron-to-metal ratios (M4B, M3B, M2B) contain isolated boron atoms, however as the proportion of boron increases (M3B2, M4B3, M3B4), borides with single and double chains of boron appear. Borides with formulae like MB4, MB6 and MB12 exist in three-dimensional arrays with open networks of boron atoms interpenetrating a regular metal atom lattice[3]. The production of metal boride usually required high temperature environment. The usual hot oven or arc discharge techniques present difficulties in the vaporization of these high temperature borides. Even though thermal excitation could produce the borides in gas phase but the thermal distribution of these molecules at high temperature will greatly complicate the absorption or emission spectra obtained. In combination with the sequence congestion and extended rotational structure which invariably accompany high temperature spectra, will probably lead to spectra which are too complex to be readily analyzed [4]. Supersonic expansion is a well-known technique for cooling the internal degrees of freedom of molecules far below the normal boiling point, while maintaining the molecules in gas phase. Recently, this method has been combined with laser vaporization / reaction source to produce high boiling transition metal compounds [5]. A localized pulsed heating of the metal or metallic compounds by focused laser irradiation is technically superior to the use of a furance since it is not necessary to heat any part of the apparatus to the extreme temperature required to vaporize refractory compounds. An intense pulse beam source of gas mixtures provides chemicals for reaction with hot metal atoms. The laser vaporization / reaction technique has been proven successful in producing metallic compounds in gas phase at a very low temperature. Laser induced fluorescence (LIF) has been developed into a standard technique for studying and monitoring various atomic, neutral, and ionic molecular species [6]. A tunable source of laser light with narrow spectral bandwidth is brought into resonance with a spectroscopic transition to an electronically excited level whose spontaneous radiative decay provides the signal to be observed. The detection of fluorescence against a background of zero or little scattered laser light is intrinsically much more sensitive than the direct measurement of absorbed light. The applicant has an on-going programme and long history of studying metal containing species in the visible and near infrard red regions using LIF spectroscopy with tunable dye laser system. We are also experienced in using the laser vaporization / reaction method to produce metal compounds in gas phase for high resolution work [7]. It is proposed here to use the laser vaporization/reaction technique to produce metal borides with LIF spectroscopy to study their electronic transitions. In this study, a widely tunable and narrow linewidth laser source for LIF spectroscopy is necessary. This is because the electronic transitions of the metal borides are not known, once they are produced in a jet, an extensive spectral search for the electronic transitions are inevitable. The narrow linewidth is required to obtain high resolution spectrum. References 1. B. Ganem and J.O. Osby, Chem. Rev. 86, 763 (1986). 2. J. Nagamatsu, N. Nakagawa, T. Muranaka, Y. Zenitani, and J. Akimitsu, Nature (London) 410, 63 (2001). 3. F.A. Cotton and G. Wilkinson, Advanced Inorganic Chemistry, 6th Edition, 1999. 4. G. Hezberg Molecular Spectra and Molecular Structure I Van Norstrand 1950. 5. S. Maruyama, L.R. Suderson, and R.E. Smally,Rev. Sci. Instrum. 61, 3686 1990. 6. D.L. Andrews, Applied Laser Spectroscopy, VCH Publishers Inc. 1992.7. A.S.C. Cheung, Q. Ran, W.S. Tam, D..K.W. Mok, P.M. Yeung, J. Mol. Spec. 203, 96 (2000) .

 

List of Research Outputs

 

Jamieson M.J., Cheung A.S.C., Ouerdane H., Jeung G.H. and Geum N.G., S-wave Scattering Lengths and Effective Ranges for Coisions of Ground State Be Atoms , Journal of Physics B: Atomic, Molecular and Optical Physics. 2007, 40: 3497-3504.

 

Li L., Leung W.H., Cheung A.S.C., Liu B.S. and Au C.T., Ch4/co2 Refforming Over La2nio4 And 10%nio/ceo2-la2o3 Catalysts Under The Condition Of Supersonic Jet Expansion Via Cavity Ring-down Spectroscopic Analysis, Catalysis Today. Elsevier, 2008, 131: 533.

 

Liu B., Au C.T., Li L. and Cheung A.S.C., Methane Aromatization Over 3 Percent Mo/HZSM-5 Catalyst Investigated by TOF-MS Under Supersonic Jet Expansion Condition , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16-20, . 2008, TJ3.

 

Pang H.F., Ye J., Leung W.H., Chen G. and Cheung A.S.C., Experimental and Theoretical Studies of Diatomic Iridium Compounds , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16,. 2008, MF12.

 

Ye J., Pang H.F., Wong M.Y., Leung W.H. and Cheung A.S.C., Laser Spectroscopy of Iridium Monoboride , The Journal of Chemical Phyics. 2008, 128: 154321-1 - 154321-6.

 

Researcher : Cheung CC



List of Research Outputs

 

Cheung C.C., Design, Fabrication and Characterization of Organic Thin Film Device (OLEDs and OTFTs) Based on Pt(II) Complexes (PhD Thesis) . 2008.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Researcher : Cheung CC



List of Research Outputs

 

Cheung C.C., Design, Fabrication and Characterization of Organic Thin Film Device (OLEDs and OTFTs) Based on Pt(II) Complexes (PhD Thesis) . 2008.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Researcher : Cheung KC



List of Research Outputs

 

Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, The Eighth International Conference on Systems Biology; 1-6 October, 2007; California, USA. . 2007.

 

Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Jiao J., Chen W., Leung K., Li S., Wang J., Cheung K.C. and Lin M.C., Intelligent Variable Structure Control for Automated Guided Vehicle, 2008 IEEE World Congress on Computational Intelligence (WCCI 2008); June 1-6, 2008; Hong Kong.. 2008.

 

Yang P., Cheung K.C., Peng Y., He M.L., Wu G., Xie D., Jiang B., Huang Q., Chen Z., Lin M.C. and Kung H., Makorin-2 is a Neurogenesis Inhibitor Downstream of PI3K/AKT Signal , The Journal of Biological Chemistry. 2008, 283: 8486-8495.

 

Researcher : Cheung KL



List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Researcher : Chiu J



Project Title:

Biochemical and proteomic analyses of arsenic carcinogenesis

Investigator(s):

Chiu J, Leung SY, He Q

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To establish and examine the processes of in vitro carcinogenesis induced by arsenic; to identify key elements of oxidative stress that involve in arsenic-induced cell transformation by biochemical and proteomic approaches; to determine which signaling pathway that mediates arsenic-induced cell transformation by proteomic approach.

 

List of Research Outputs

 

Lok C.N., Ho C.M., Chen R., Tam P.K.H., Chiu J. and Che C.M., Proteomic identification of the Cus system as a major determinant of constitutive escherichia coli silver resistance of chromosomal origin, Journal of Proteome Research. 2008, 7: 2351-2356.

 

Researcher : Chiu P



Project Title:

Applications of copper hydride reductions to organic synthesis

Investigator(s):

Chiu P

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2002

 

Abstract:

The project will examine substrates including alkynones and nitroalkenes, that will undergo stereoselective reductive aldol reaction to achieve new motifs in the products. Intermolecular aldol reaction will be developed to make the protocol more generally applicable to organic synthesis. Efforts will be devoted to achieve a catalytic reductive aldol reaction, which will make this reaction more economical and environmentally sound.

 

Project Title:

Synthetic Studies toward Guanacastepene A

Investigator(s):

Chiu P, Toy PH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2004

 

Abstract:

To study the carbene cyclization cycloaddition cascade reaction and its application to the synthesis of the BC ring system of guanacastepene A; to synthesize and characterize monomers and polymers bearing arsine residues; to evaluate the use of immobilized arsines in organic synthesis, and its application to the synthesis of guanacastepene; to use of Nazarov cyclization strategy to elaborate the BC ring system to the ABC rings of guanacastepene; to engage in studies toward the asymmetric total synthesis of guanacastepene A.

 

Project Title:

Investigations on the reduction of activated dienes

Investigator(s):

Chiu P

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2006

 

Abstract:

1. To explore reaction conditions to reduce activated alkenes 2. To investigate catalytic reduction reactions for activated alkenes.

 

Project Title:

Novel [4+3] cycloaddition reactions for the synthesis of functionalized cycloheptenones

Investigator(s):

Chiu P

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2006

 

Abstract:

(1) To explore the scope of the [4+3] cycloaddition using epoxy enol silanes as cation precursors. Our previous work funded by RGC (HKU 7103/00P) developed reaction conditions that tremendously escalated the yield of the cycloaddition and showed that the intramolecular reaction proceeds with excellent yield and diastereoselectivity. With these preliminary results in hand, we are in a position to more fully develop and exploit these reactions for synthesis. The reactions of additional dienes and epoxy enol silane substrates will be explored to synthesize a range of new highly functionalized polycyclic structures as intermediates for the synthesis of natural products. (2 ) To developed improved conditions for the [4+3] cycloaddition. The present reaction uses stoichiometric amounts of Lewis acids as activators. The goal is to develop a process catalytic in Lewis acid. Parameters that will be examined include solvents and different Lewis acids. The successful development of these conditions would provide the foundation to create a catalytic asymmetric process. (3) To improve the diastereoselectivity of the [4+3] reaction. The selectivities of the present cycloaddition ranges from low to very high. Mechanistic studies will be done to find the origins of these diastereoselectivities. Based on these results, conditions to maximize the directing factors could lead to a highly diastereoselective reaction for synthesis. (4) To explore alternative epoxy enol silanes as oxyallyl cation precursors. Besides improving aspects of the existing reaction, novel oxyallyl cation precursors will be designed based on vinyl epoxy silanes. The successful implementation of this reaction could lead to the development of a new class of functionalized cycloheptenones. (5) To develop this [4+3] cycloaddition process for making enantiomerically enriched cycloheptenones. The demands of synthesis in the pharmaceutical industry today are increasingly for single enantiomers of intermediates and products. The investigations of asymmetric induction and the use of chiral activators in this cycloaddition process could yield an asymmetric methodology for the synthesis of highly functionalized cycloheptenone enantiomers. (6) To apply the results of these studies and evaluate the [4+3] cycloaddition as a key step in the synthesis of natural products. A possible target of which the cycloheptenone is a key structure is the protein kinase C inhibitor, ingenol. Presently the shortest total synthesis of ingenol is 32 steps. The [4+3] cycloaddition would be an efficient strategy to synthesize this natural product, but previous attempts using this cycloaddition failed to make the core structure. The present studies could provide additional results to make the [4+3] cycloaddition a viable and efficient route.

 

Project Title:

Reductive or alkylative ring opening of oxabicyclic compounds

Investigator(s):

Chiu P

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

The purpose of the proposed project is to investigate ring opening reactions of compounds having the [3.2.1] oxabicyclic nculeus via a reductive or an alkylative route. The reactions, if successful, would be very useful methods to derivatize oxabicyclic compounds, in ways that would generate the carbocyclic frameworks of numerous natural products and bioactive compounds. Oxabicyclic compounds are versatile intermediates, readily synthesized and having a facial and stereochemical bias which make subsequent reactions highly selective. One of the most important ways to manipulate these compounds are reactions which cleave the oxygen bridge. This is because while the oxygen bridge confers significant stability to the compound, as well as provide a strong facialselectivity for reactions, the oxygen bridge itself is not a motif often found in natural and bioactive compounds. Thus methods to cleave the oxygen bridge are required in order of oxabicyclic compounds to be useful for synthesis in general. Additional functionalizations in the course of oxygen bridge opening would increase the usefulness of the methodology and the generality of use of oxabicyclic compounds in synthesis.

 

List of Research Outputs

 

Chiu P., Extending the Scope of the Carbene Cyclization Cycloaddition Reaction , International Symposium on Catalysis and Fine Chemicals 2007, Singapore, December 16-21, 2007. 2007.

 

Chiu P., Lam S.K. and Leung L.T., Studies Toward the Asymmetric Synthesis of Secodolastanes and Dolastanes: Indicol and Dolatriol , The 40thNational Organic Symposium, Duke University, North Carolina, U.S.A., June 3-7, 2007. Poster A52.

 

Chiu P., Lam S.K. and Leung L.T., Synthesis Studies on Secodolastnes and Dolastanes: Indicol and Dolatriol, The 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Korea, September 2. 2007.

 

Chiu P., The 2nd International Conference on Cutting-edge Organic Chemistry in Asia, Asian Core Program Lectureship Award , Sponsored by the Japan Society for Promotion of Science, Japan . 2007.

 

Chiu P., The 2nd International Conference on Cutting-edge Organic Chemistry in Asia, Asian Core Program Lectureship Award , Sponsored by the National Science Foundation of China, China . 2007.

 

Chiu P., Total Synthesis of Natural Products Using a Carbene Cyclization Cycloaddition Cascade Strategy , The 2007 US National Foundation (NSF) -- Research Experience for Undergraduates Symposium, Thailand, August 4, 2007. 2007.

 

Chung W.K., Lam S.K., Lo B.T.K. and Chiu P., [4+3] Cycloadditions Using Epoxy Enol Silanes as Oxyallyl Cation Precursors , The 18th IUPAC International Conference on Organic Synthesis, Korea, June 22. 2008.

 

Geng Z., Chen B. and Chiu P., The University Research Output Prize 2006-2007, The HKU University Research Committee, Hong Kong . 2007.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis (-) - Indicol by a Carbene Cyclization-Cycloaddtion Cascade Strategy, Chemistry – A European Journal. Wiley, 2007, 13: 9589-9599.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis of (-) –Indicol by a Carbene Cyclization – Cycloaddition Cascade Strategy , Chemistry - A European Journal. 2007, 13: 9589-9599.

 

Li S. and Chiu P., Acid-promoted Sequential Cationic Cyclizations for the Synthesis of (±) -Taiwaniaquinol B, Tetrahedron Letters. 2008, 49: 1741-1744.

 

Researcher : Cho CKL



List of Research Outputs

 

Cho C.K.L., Yang Y., Chu I.K., Haynes R.K. and Sze K.H., 3D Structure Determination and Comparison of Natural Loloatin Family and all L-loloatins by Nuclear Magnetic Resonance Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-18.

 

Researcher : Choi WKS



List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Researcher : Choy TSJ



List of Research Outputs

 

Choy T.S.J., Enhancing the Sensitivity and Spectificity of Piezoelectric Quartz Crystal Sensor by Nano-crystal Sensor by Nano-gold Amplification and Molecularly Imprinting Technologies (PhD Thesis) . 2008.

 

Choy T.S.J., Yam W.C., Yao S.Z. and Fung Y.S., Improved Detection Sensitivity of the Nucleic Acid / Piezoelectric Quartz Crystal Biosesor Through Nano-god Application, Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007. P-36, pp66.

 

Fung Y.S., Wong C.C.W., Choy T.S.J. and Sze K.L., Determination of Sulphate in Water by flow-injection Analysis with Electrode-separated Piezolectric Quartz Crystal Sensor , Sensors and Actuators B . 2008, 130: 551-560.

 

Sun H., Choy T.S.J., Yam W.C., Ng S.P. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Assay of Low E.coli count in Water, The 10th World Congress on Biosensors . 2008, P1.158.

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Researcher : Chu IK



Project Title:

Dissociation of Molecular Radical Cationic Oligopeptides

Investigator(s):

Chu IK

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2005

 

Abstract:

The proposed studies will focus on obtaining a fundamental understanding of the dissociation pathways of peptide radical cations using a combination of tandem mass spectrometry experiments and density functional theory (DFT) calculations. In addition, we will study the energetics of dissociation of these species using RRKM-based modeling of the time- and collision energy-resolved SID data. Understanding the fragmentation mechanisms of peptides is a key step that is required prior to establishing strategies for gas-phase peptide sequencing.

 

Project Title:

Facile generation and characterization of cationic and anionic radical peptides: ligand effects and peptide structures

Investigator(s):

Chu IK

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2006

 

Abstract:

(1) To investigate fundamental factors governing competitive reactions: a. Macrocyclic effect of auxiliary ligand. (2 ) To investigate fundamental factors governing competitive reactions: b. Peptide modification to control radical peptide formation. (3) To develop methodology for the synthesis of novel anionic radical peptides in the gas-phase. (4) To improve the fundamental understanding of one-electron transfer and to explore the factors that govern the formation of a variety of radical peptides.

 

List of Research Outputs

 

Cho C.K.L., Yang Y., Chu I.K., Haynes R.K. and Sze K.H., 3D Structure Determination and Comparison of Natural Loloatin Family and all L-loloatins by Nuclear Magnetic Resonance Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-18.

 

Chu I.K., Zhao J., Xu M., Siu S.O., Hopkinson A.C. and Siu K.W.M., Are the Radical Centers in Peptide Radical Cations Mobile? The Generation, Tautomerism, and Dissociation of Isomeric a-Carbon-Centered Triglycine Radical Cations in the Gas Phase, Journal of the American Chemical Society. 2008, 130: 7862-7872.

 

Chu I.K., Formation and Dissociation of Radical Peptide Ions , Department of Chemistry, Beijing Normal University, Beijing. 2007.

 

Chu I.K., Mass Spectrometry based-Metabolomics, Institute of Chinese Medical Science, University of Macau, Macau. 2007.

 

Laskin J., Yang Y., Lam N.W. and Chu I.K., Charge-Remote Fragmentation of Odd-Electron Peptide Ions, Analytical Chemistry. 2007, 79: 6607-6614.

 

Laskin J., Futrell J.H. and Chu I.K., Is Dissociation of Peptide Radical Cations an Ergodic Process?, Journal of the American Chemical Society . 2007, 129: 9598-9599.

 

Laskin J., Yang Z. and Chu I.K., Energetics and Dynamics of Electron Transfer and Proton Transfer in Dissociation of MetalIII(salen)-Peptide Complexes in the Gas Phase, Journal of the American Chemical Society. 2008, 130: 3218-3230.

 

Lo C.S.C., Le Blanc J.C.Y., Yu K.Y., Sze K.H., Ng D.C.M. and Chu I.K., Detection, Characterization, and Quantification or Resveratrol Glycosides in Transgenic Arabidopsis Over-expressing a Sorghum Stibene Synthase Gene by Liquid Chromatography / Tandem Mass Spectrometry , Rapid Communications in Mass Spectrometry . 2007, 21: 4101-4108.

 

Shih C.H., Chen Y., Wang M., Chu I.K. and Lo C.S.C., Accumulation of isoflavone genistin in transgenic tomato plants overexpressing a soybean isoflavone synthase gene, Journal of Agricultural and Food Chemistry. 2008, 56: 5655-5661.

 

Yu K.Y., Shih C.H., Chu I.K. and Lo C.S.C., Accumulation of trans-piceid in sorghum seedlings infected with Colletotrichum sublineolum, Phytochemistry. 2007, 69: 700-706.

 

Researcher : Chu LM



List of Research Outputs

 

Chu L.M., Time-resolved Spectroscopic Investigation of Chloroaniline and Oxetane Related Compounds (MPhil Thesis). 2007.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Researcher : Chu TT



List of Research Outputs

 

Chu T.T., Biomimetic Reactions of Nitric Oxide Synthase - Study of the Reactions of N-Substituted-N'-Hydroxyguanidines with Metalloporphyrin and Non-heme Complexes (PhD Thesis). 2007.

 

Researcher : Chu YY



List of Research Outputs

 

Yuen H.F., Chan Y.P., Chan K.K., Chu Y.Y., Wong M.L.Y., Law S.Y.K., Srivastava G., Wong Y.C., Wang X. and Chan K.W., Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma, Br J Cancer. 2007, 97(10): 1409-15.

 

Researcher : Chuang YP



List of Research Outputs

 

Xue J., Du Y., Chuang Y.P., Phillips D.L., Wang J., Luk C., Hadad C.M. and Platz M.S., Time-Resolved Resonanc Raman Observation of the Dimerization of Didehydroazepines in Solution , Journal of Physical Chemistry A. 2008, 112: 1502-1510.

 

Researcher : Chui SY



List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Lu W., Chui S.Y., Ng K.M. and Che C.M., A Submicrometer Wire-to-Wheel Metamorphism of Hybrid Tridentate Cyclometalated Platinum(II) Complexes, Angewandte Chemie International Edition. 2008, 47: 4568.

 

Researcher : Chung WK



List of Research Outputs

 

Chung W.K., Lam S.K., Lo B.T.K. and Chiu P., [4+3] Cycloadditions Using Epoxy Enol Silanes as Oxyallyl Cation Precursors , The 18th IUPAC International Conference on Organic Synthesis, Korea, June 22. 2008.

 

Researcher : Chung WY



List of Research Outputs

 

Chung W.Y., Development of a Multipolymer Reaction and Polyfunctional Polymeric Catalysts (PhD Thesis) . 2008.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Cun S



List of Research Outputs

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Ge R. and Cun S., Identification of bismuth-binding proteins in Helicobacter pylori by a metalloproteomic approach, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Researcher : Deng Q



List of Research Outputs

 

Deng Q., Xu H.W., Yuen A.W.H., Xu Z.J. and Che C.M., Ruthenium-Catalyzed One-Pot Carbenoid N-H Insertion Reactions and Diastereoselective Synthesis of Prolines , Organic Letters. 2008, 10: 1529-1532.

 

Researcher : Ding J



List of Research Outputs

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Chan G.K.Y., Ren J., Wang H. and Ding J., Strategies of Nanostructing Fuel Cell Electrodes , Proceedings of 2007 First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007.

 

Researcher : Du Y



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Du Y., Xue J., Ma C., Kwok W.M. and Phillips D.L., Time-resolved Resonance Raman and Density Functional Theory Study of the Photochemistry of 4-Benzoylpyridine in Acetonitrile and 2-Propanol , Journal of Raman Spectroscopy . 2008, 39: 503-514.

 

Du Y., Time-resolved Spectroscopic Studies of the Photophysics and Photochemistry of Selected Benzoin and Benzophenone Compounds (PhD Thesis) . 2008.

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Xue J., Du Y., Chuang Y.P., Phillips D.L., Wang J., Luk C., Hadad C.M. and Platz M.S., Time-Resolved Resonanc Raman Observation of the Dimerization of Didehydroazepines in Solution , Journal of Physical Chemistry A. 2008, 112: 1502-1510.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Du Y



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Du Y., Xue J., Ma C., Kwok W.M. and Phillips D.L., Time-resolved Resonance Raman and Density Functional Theory Study of the Photochemistry of 4-Benzoylpyridine in Acetonitrile and 2-Propanol , Journal of Raman Spectroscopy . 2008, 39: 503-514.

 

Du Y., Time-resolved Spectroscopic Studies of the Photophysics and Photochemistry of Selected Benzoin and Benzophenone Compounds (PhD Thesis) . 2008.

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Xue J., Du Y., Chuang Y.P., Phillips D.L., Wang J., Luk C., Hadad C.M. and Platz M.S., Time-Resolved Resonanc Raman Observation of the Dimerization of Didehydroazepines in Solution , Journal of Physical Chemistry A. 2008, 112: 1502-1510.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Duan G



List of Research Outputs

 

Li M., Ko C.C., Duan G., Zhu N. and Yam V.W.W., Functionalized Rhenium(I) Complexes with Crown Ether Pendants Derived from 1,10-Phenanthroine: Selective Sensing for Meta Ions , Organometallics. 2007, 6091-6098.

 

Researcher : Fang GS



List of Research Outputs

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Researcher : Fung YS



Project Title:

PCR-based DNA quartz piezoelectric biosensor for determination of E. Coli in environmental and food samples

Investigator(s):

Fung YS, Ng SP, Yam WC

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

 

Abstract:

To investigate and select a suitable primer and probe for use in the Polymerase Chain Reaction (PCR) to amplify appropriate DNA sequence for E. coli determination using the piezoelectric crystal (PZ) biosensor; to develop and optimize the coating procedure for a single strand Deoxyribonucleic Acid (ssDNA) onto the quartz piezoelectric crystal surface; to investigate the mechanism for the procedures during immobilization and hybridization of ssDNA of E. coli using various techniques based on Scanning Probe Microscope (SPM); to correlate the PCR-based DNA PZ signal with the bacteria count using the real-time PCR and Capillary Electrophoresis (CE) for quantitative determination; to optimize the working conditions, determine the analytical parameters and study the field application of PCR-based DNA quartz PZ biosensor.

 

Project Title:

Nanoparticle Characterization Technology for Biomedical Research and Diagnostic Application

Investigator(s):

Fung YS, Yeung WSB, O WS

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2006

 

Abstract:

Introduction The proposed project aims to investigate the applicability of the nanoparticle characterization technology in the areas of biomedical research and diagnosis. The technology has been developed by Dr Fung with the support of the Innovation and Technology Fund (ITF) project (Fung, Li and Zhu, 2005) awarded by the Innovation and Technology Commission (ITC) on the development of Nanotechnology for sizing and collection of polymeric nanoemulsions for industrial quality control and assessment application. During the ITF project started in March 2002 till August 2004, we have built and tested the following equipment and facilities for sizing, counting, collection and characterization of polymeric nano-particles: Electrospray Aerosol Generator, Scanning Mobility Particle Sizer, Condensation Particle Counter and the Nanometer Aerosol Sampler/Collector for collection of nanoparticles for Dynamic Laser Scattering studies and characterization by TEM, SEM, AFM, ICP-MS and other techniques available in the University. The system allows intact electrospray of industrial polymeric nanoemulsions for separation according to their m/e ratio, counting the number of nanoparticles within a given size range and collection of nanoparticles separated for subsequent morphological and chemical characterization by other advanced techniques. This is the first set of equipment and facilities built specially for characterization of industrial polymeric nanoemulsions for quality control purpose. Using the equipment and facilities built to provide a reliable laboratory-based methodology for accurate sizing and characterization of soft nanoparticles, we have successfully developed both the equipment and methodology of the Capillary Electrophoretic Nano-sizing Technology (CENST) and tested its applicability in factory at Pearl River Delta area for onsite quality assessment of industrial nano-emulsions. We have been invited by the ITC to submit a bid for the State Technological Invention Award (STIA) and the State Scientific and Technological Progress Award (SSTPA) under the 2006 State Science and Technology Awards Scheme. In addition, we have invited by the Hong Kong Productivity Council to further develop the electrophoretic nanotechnologies for automobile application and acted as one of the initiating projects for the R & D centre on automobile which have received approval from the ITC and Legislative Council and will be started early next year. Since the completion of the ITF project in August last year, we have explored the possibility of the nanotechnology developed for biomedical application, as many biomolecules such as proteins and subcelluar organelles (e.g. mitochrondria) are in nanometric sizes and our techniques developed can be applied for their separation and characterization. With a new graduate student coming in January 2005 to Dr Fung’s group, a procedure for determining free and protein-bound calcium in milk samples has been developed using the nanoparticle characterization technology developed with results presented at the 8th Asianalysis meeting held in Taipei in October this year (Fung and Sze, 2005). We are in the process of writing a paper on the work presented.. During the Joint Retreat of the Strategic Research Theme of Development and Reproduction & Centre for Reproduction, Development and Growth held at the end of June, I have met and discussed with Dr S.B. Yeung and other colleagues in the medical faculties, and found that there are strong interest in calcium speciation, counting and characterization of biomedical nanoparticles. The following project has been formulated with details given below : Backgrounds : Calcium homeostasis is important for fertilization and early embryonic development. The entry of the sperm into the oocyte causes repetitive release of calcium from intracellular calcium store leading to oscillation in the cytosolic free Ca2+ concentration [Ca2+]i (Stricker, 1999; Dumollard et al., 2002). The frequency and the amplitude of this calcium oscillation provide cues leading to completion of meiosis and initiation of embryonic development (Ozil and Huneau, 2001). The calcium concentration in these studies was determined by calcium ratio imaging. Currently, there is no established method in determining bound calcium in oocyte, though calcium-binding proteins have been detected in oocyte (Balakier et al., 2002). Mitochondria are important organelles in regulating intracellular calcium homeostasis in oocytes. Sperm-triggered calcium oscillations stimulate mitochondrial ATP production (Hajnoczky et al., 1995; Dumollard et al., 2003, 2004), which in turn regulates intracellular Ca2+ release (Mak et al., 1999). Mitochondrial dysfunction in mouse oocytes impairs Ca2+ clearance from the cytosol (Liu et al., 2001). Evidence show that mitochondrial ATP generation in oocyte is crucial to the maintenance of a low resting [Ca2+]i and for sustenance of sperm-triggered calcium oscillations (Dumollard et al, 2004). Aging is associated with changes in mitochondria within the oocyte. Mitochondria in aged oocytes have features found in senescent somatic cells (Motta et al., 2000; de Bruin et al., 2004) and apoptotic somatic cells (Müller-Hocker et al., 1996; Lee and Wei, 2001), show sign of degradation (Sundstrom and colleagues 1985) and more frequent point mutations and rearrangements of mitochondrial DNA (Barritt et al., 1999). Aging is also related to decline in mitochondrial charge (Wilding et al., 2001), which has been associated with increased levels of mosaicism in embryos (Wilding et al., 2003). Aged mouse oocytes have defective regulation of intracellular ATP at fertilization (Igarashi et al., 2005). Whether these age-related changes in mitochondria would affect the calcium homeostasis in oocyte from advanced aged mammals is not entirely known. Hypothesis Calcium homeostasis is defective in aging oocytes. Objectives 1.To develop the electrophoretic methodology for determining free and bound calcium concentration in mouse oocytes 2.Based on the method developed, to compare the concentration of free and bound calcium in oocytes from mature and aged mice. 3. To develop the nanoparticle characterization methodology for counting, separation and characterization of mitochondria in aged as compared to matured oocytes. References: Pooled together with other sections and placed at the end of the Research Plan and Methodology section.

 

Project Title:

Electronic tongue by quartz piezoelectric crystal with molecularly imprinted polymer recognition

Investigator(s):

Fung YS, Zhu D, Sun H

Department:

Chemistry

Source(s) of Funding:

Innovation and Technology Support Programme

Start Date:

09/2006

 

Abstract:

1) The development of the quartz piezoelectric technology as a technology platform for electronic tongue. 2) The development of the molecularly imprinted polymer technology for recognization of taste generating molecules in different ingredients from food products. 3) Based on the chemometric computer pattern recognition technique and chemical information obtained from an array of quartz crystal sensors with MIP coatings, an electronic tongue will be developed to differentiate and quantity taste from difference ingredients of food products. 4) With a prototype of the electronic tongue developed, conduct field testing of the electronic tongue in selected food industries.

 

List of Research Outputs

 

Chen Q. and Fung Y.S., Quantum Dots for Detection of Organophosphorus Pesticides , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:60, pp 5:145.

 

Choy T.S.J., Yam W.C., Yao S.Z. and Fung Y.S., Improved Detection Sensitivity of the Nucleic Acid / Piezoelectric Quartz Crystal Biosesor Through Nano-god Application, Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007. P-36, pp66.

 

Fung Y.S., Capillary Electrophoresis for Biomedical and Environmental Analysis , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007.

 

Fung Y.S., Chairman of Organizing Committee for the Events. , Hong Kong Chemistry Olympiads, Tertiary Institutions: 1990 - 2008, Secondary Schools, 1996 - 2008. Activity Jointly Organized by the Educaton Department (HKSAR Government), Royal Society of Chemistry, the Hong Kong Chemical Society, Hong Kong Association for Science and Mathematics Education. 2008, Hong Kong . 2007.

 

Fung Y.S., Council Member , The Hong Kong Chemical Society, 1987 - 2008, Hong Kong . 2007.

 

Fung Y.S., Council Member , The Hong Kong Metal Finishing Society, March 2005 - June 2008, Hong Kong . 2007.

 

Fung Y.S., Wong C.C.W., Choy T.S.J. and Sze K.L., Determination of Sulphate in Water by flow-injection Analysis with Electrode-separated Piezolectric Quartz Crystal Sensor , Sensors and Actuators B . 2008, 130: 551-560.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-Methyl-3-Ethylimidazolium Chloride / Urea System, Proceedings of 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007. TThB1, pp109.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-methyl-3-ethylimidazolium Chloride / Urea System , International Symposium of Task-specific Ionic Liquids, Keio University, Yokohama, Japan, August 3-4, 2007. 2007.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-methyl-3-ethylimidazolium Chloride / Urea System , 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007. 2007.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin and its Alloys from Room Temperature Ionic Liquid Based on the 1-Methyl-3-Ethylimidazolium Chloride Systems , Proceedings, International Symposium on Task-Specific Ionic Liquids, Keio University, Yokohama, Japan, August 3-4, 2007. pp17.

 

Fung Y.S., Executive Board Member , Air & Waste Management Association (U.S.), 1996 - 2008, U.S.A. . 2007.

 

Fung Y.S., Member of 1st Molten Salt Committee from the Physical Metallurgical Chemistry Professional Committee, Chinese Metal Society, 2003 - 2008, Hong Kong . 2007.

 

Fung Y.S., Member of Editorial Board , Journal of Biochemical and Biophysical Methods, January 2005 -- March 2008, Amsterdam, The Netherlands. 2007.

 

Fung Y.S., Member of Editorial Board, Chemistry Education , Chinese Chemical Society, April 2000 -- June 2008. 2007.

 

Fung Y.S., Member of Hong Kong Green Label Scheme (HKGLS) Adisory Committee, Green Council, August 2005 - June 2008, Hong Kong . 2007.

 

Fung Y.S., Member of Organic Committee, Green Producrts / Componet Finishing Techolory-advanced Process for Compliance to RoHs / WEEE and ELV Directives , Green Products / Componet Finishing Intermational Symposium Organixzed by the Hong Kong Metal Finishing Society, Innovation and Technology Commission and Hong Kong Prodctivey Coucil, October 2005-2007. 2007.

 

Fung Y.S., Member of Organizing Committee, 2007 International Conference on Nanotechnology & Advanced Materials, Organized by the Federation of Hong Kong Machinery and Metal Industries Ltd and Held in Hong Kong, December 11-13, 2008. 2007.

 

Fung Y.S., Member of Working Group on Regulatory Contro of Volatile Organic Compounds (paint Subgroup), Enivronmental Proteciton Department (HKSAR Government), May 2005 - June 2008, Hong Kong . 2007.

 

Fung Y.S., Member, International Advisory Board and Scientific Committee, 6th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. 2007.

 

Fung Y.S., Member, International Advisory Board and Scientific Committee, 7th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE 2007), December 16-19, 2007, Singapore . 2007.

 

Fung Y.S., Member, International Advisory Board and Scientific Committee, 8th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE 2008), Kaohsiung, Taiwan, November 2-5, 2007. 2007.

 

Fung Y.S., Microfluidic Chip - Capillary Electrophoresis for Biomedical and Environmental Analysis, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:14, pp 5:128.

 

Fung Y.S., Mircrochip-capillary Electrophoresis for Biomedical Application in Hong Kong , Workshop on "Microfluidics and its Application" Hong Kong, December 12, 2007. WP.04.

 

Fung Y.S., University Advisor , Chemical Engineering Section of the Hong Kong Critical Components Manufactures Association, Feburary 2003 - June 2008, Hong Kong. 2007.

 

Guo W. and Fung Y.S., Dual-Electrode Detection of Amino Acids for Microfluidic Chip, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:43, pp 5:139.

 

Nie Z. and Fung Y.S., Microchip Capillary Electrophoresis for Frontal Analysis of Free Bilirubin and Study of its Interaction with Human Serum Albumin , Electrophoresis. 2008, 29: 1924-1931.

 

Nie Z. and Fung Y.S., Mircofluidic Chip-Capillary Electrophoresis for Quality Assessment of a Complex Herbal Preparation , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:48, pp 5:141.

 

Nie Z. and Fung Y.S., Multi-segment Incremental Sample Injection for the Determination of Bilirubin Binding Capacity of Albumin and Study of Drug Interaction by Microchip Capillary Electrophoresis , 22nd International Symposium of Microscale Bioseparations & Methods for System Biology (MSB 2008), Berlin, Germany, March 9-13, 2008. Paper P.284-Tu, pp417.

 

Sun H., Choy T.S.J., Yam W.C., Ng S.P. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Assay of Low E.coli count in Water, The 10th World Congress on Biosensors . 2008, P1.158.

 

Sun H., Yam W.C., Ng S.P., Li Z. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Detection of E. Coli in Environmental Water , Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007 . 2007, p41, pp71.

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Sun H. and Fung Y.S., Separation and Determination of Carbonyls by Gradient Elution Micellar Electrokinetic Capillary Chromatography , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:61, pp 5:145.

 

Sze K.L. and Fung Y.S., Capillary Electrophoresis for the Determination of Trace Metals in milk , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:59, pp 5:144.

 

Sze K.L., Yeung W.S.B. and Fung Y.S., Separation and Determination of Metal Cations in Milk and Dairy Products by CE, Electrophoresis. 2007, 28: 4156-4163.

 

Wu R., Fung Y.S. and Yeung W.S.B., Microfluidic Chip-capillary Electrophoresis for 2-D Separation of Proteins, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:49, pp 5:141.

 

Zhao W., O W.S. and Fung Y.S., Quantitation of Mitochondria Separated by Capillary Electrophoresis , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:50, pp 5:141.

 

Zhu D. and Fung Y.S., Electrodeposition of Tin Alloy Electrode in Ternary Ionic Liquid (MEIC-urea SnC12) for Lithium Battery Application , Proceedings 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007 . 2007, 1P07-077, pp200.

 

Zhu D., Sun H. and Fung Y.S., Electrodeposition of Tin from the 1-Methyl-3-Ethyllimidazolium Chloride/AlCl3SnCl2 Room Temperature Molten Salts , Electrochemical Society Transactions . 2007, 3: 239-248.

 

Researcher : Gao Q



List of Research Outputs

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Researcher : Ge R



List of Research Outputs

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Ge R. and Cun S., Identification of bismuth-binding proteins in Helicobacter pylori by a metalloproteomic approach, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Researcher : Ge R



List of Research Outputs

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Ge R. and Cun S., Identification of bismuth-binding proteins in Helicobacter pylori by a metalloproteomic approach, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Researcher : Geng Z



List of Research Outputs

 

Geng Z., Chen B. and Chiu P., The University Research Output Prize 2006-2007, The HKU University Research Committee, Hong Kong . 2007.

 

Researcher : Gu Y



List of Research Outputs

 

Lau J.P.K., Gu Y. and Wong W.T., High-yield Synthesis of a New layered High-nuclearity Carbonyl Osmium-rhodium Cluster Complex -- Synthesis Structural Characterization, and Electrochemistry of [PPN][Os9Rh3(m-CO)2(CO)26], European Journal of Inorganic Chemistry. 2007, 3011-3014.

 

Wong S.Y., Gu Y., Sze-To L. and Wong W.T., An Open-channel Architecture Assembly from the [Os3(CO)8{m-h3-ON=CPh(NC5H4)}2] Cluster , Crystengcomm. 2008, 10: 29-33.

 

Researcher : Guan X



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Guan X., Wong K.B. and Sze K.H., Dynamics Study of a Thermophilic Acyphosphatase and its Mutants from Pyrococcus Horikoshii by NMR Spectroscopy , International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A06.

 

Guan X., Wong K.B. and Sze K.H., Structure and Dynamics of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy -- Structural Basis of Thermostability and Enzymatic Activities , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-19.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Researcher : Guan X



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Guan X., Wong K.B. and Sze K.H., Dynamics Study of a Thermophilic Acyphosphatase and its Mutants from Pyrococcus Horikoshii by NMR Spectroscopy , International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A06.

 

Guan X., Wong K.B. and Sze K.H., Structure and Dynamics of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy -- Structural Basis of Thermostability and Enzymatic Activities , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-19.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Researcher : Guan X



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Guan X., Wong K.B. and Sze K.H., Dynamics Study of a Thermophilic Acyphosphatase and its Mutants from Pyrococcus Horikoshii by NMR Spectroscopy , International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A06.

 

Guan X., Wong K.B. and Sze K.H., Structure and Dynamics of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy -- Structural Basis of Thermostability and Enzymatic Activities , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-19.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Researcher : Guo W



List of Research Outputs

 

Guo W. and Fung Y.S., Dual-Electrode Detection of Amino Acids for Microfluidic Chip, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:43, pp 5:139.

 

Researcher : Guo Z



List of Research Outputs

 

Guo Z., Lin X., Zhao C. and Phillips D.L., Density Functional Theory Study of Water-assisted Deprotonation of the C8 Intermediate in the Reaction of the 2-Fluorenylnitrenium Ion with Guanosine to form a C8 Adduct, Journal of Molecular Structure: THEOCHEM. 2008, 848: 119-127.

 

Guo Z., Ke Z.F., Phillips D.L. and Zhao C.Y., Intrinsic Reaction Coordinate Analysis of the Activation of CH4 by Molybdenum Atoms: A Density Functional Theory Study of the Crossing Seams of the Potential Energy Surfaces , Organometallics. 2008, 27: 181-188.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Han J



List of Research Outputs

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Researcher : He Q



Project Title:

Proteomic approach to study metastasis of esophageal squamous cell carcinoma

Investigator(s):

He Q

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

06/2006

 

Abstract:

Background: Esophageal squamous cell carcinoma (ESCC) is the fourth most common malignancy and still represents a great health concern in China. Most of the patients cannot survive more than one year after presenting at healthcare centers and the 5-year survival rate for ESCC remains as low as 10 percent or even less. One of the main reasons for the ominous phenomena is that neoplasms in esophagus are not detected until they have invaded the surrounding tissues or spread throughout the body (metastasis) at advanced stages. The early detection and diagnosis of esophageal malignancy is critical for its therapy and management. Tumor metastasis is the spread of cancer cells from the original site to other parts of the body. It is a very complex and multi-step process and often referred to as a cascade. The process of metastasis formation begins with some tumor cells breaking adhesions with neighboring cells and detaching from the primary tumor. Those cells then dissolve the extracellular matrix, migrate and invade surrounding tissues, and/or travel via the circulatory system, invade, survive and proliferate at distant new sites. Metastasis is by far the leading cause of death in cancer patients including ESCC, responsible for more than 90% of all cancer mortality. Lymph node metastasis is a strong and dominant prognostic aspect for ESCC. Lymphatic invasion represents a physiological predictor of lymph node metastasis in patients with ESCC and is a factor significantly influencing overall survival rate. However, the molecular mechanism underlying the lymphatic invasion of cancer cells in ESCC is still unclear. Several proteins such as HIF-1α and VEGF family have been individually studied and their expression was reported to correlate with the depth of tumor invasion, tumor stage, venous invasion, lymphatic invasion, and lymph node metastasis. However, there is still lacking systematic data showing the molecular factors and their interactions in the process of lymphatic metastasis of ESCC. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomics provides an effective methodology to globally examine the different protein expressions and protein interactions in disease. Proteomic technology has been widely used in biomarker discovery, target identification and pathogenetic studies including tumor metastasis. We have used 2D-gel based proteomics to compare the protein profiles between ESCC tumor and matched surrounding tissues and to identify differently expressed proteins in the esophageal cancer. A number of tumor-associated proteins including SCCA1, transgelin, TPM, prohibitin, PRX, aB-Cryst and MnSOD was detected with altered expressions, corresponding to a complicated multi-step process involved in the initiation, formation and progression of esophageal carcinoma (Proteomics, 2005, 5:2960-2971). However, ESCC metastasis has not been investigated by proteomic approach up today. Objectives: The main objective of this proposal is to study ESCC metastasis by proteomic technology. Using our established 2DE-based proteomics, we plan to profile and compare the proteomes and sub-fractions extracted from cultured esophageal cancer cells with one bearing proved metastatic potential. We will systematically characterize the differently expressed proteins in metastatic cells and identify the molecular factors correlated to the tumor invasion and metastasis.

 

List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

He Q., Zhu R., Lei T., Ng M.Y.M., Luk J.M.C., Sham P.C., Lau G. and Chiu J., Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma, Journal of Cellular Biochemistry. 2008, 103: 740-752.

 

Kwan W.Y., Yeung H.Y., He Q., Lee A.S., Liu J. and Wong A.S.T., The unfolded protein response regulatory GRP78 is a novel target of BRCA1 for inhibiting stress-induced apoptosis, Annual Meeting of the American Association of Cancer Research, San Diego, CA. p. 212 (Abstract No. 1785) . 2008.

 

Lo A.C.Y., Cheung A.K.H., Yeung C.M., He Q., Chiu J., Chung S.S.M. and Chung S.K., Deletion of aldose reductase leads to protection against cerebral ischemic injury., Journal of Cerebral Blood Flow and Metabolism. 2007, 27: 1496-1509.

 

Sun S., Lee P.Y., Poon R.T.P., Fan S.T., He Q., Lau G. and Luk J.M.C., Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways (Review Article), Liver International. 2007, 27(8): 1021-1038.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Zhou Y., Bhatia I., Cai Z., He Q., Cheung P.T. and Chiu J., Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins, J Proteome Research. 2008, 7: 2507.

 

Researcher : He W



List of Research Outputs

 

He W. and Yang D., Redesigning Pd(II)-Catalyzed Asymmetric Oxidative Cascade Cyclization, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Ho CM



List of Research Outputs

 

Cheung O.F.S., Wong K.K.Y., Ho C.M., Che C.M. and Tam P.K.H., The anti-inflammatory properties of nanosilver , The 12th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 12 - 14 December 2007.

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Lok C.N., Ho C.M., Chen R., Tam P.K.H., Chiu J. and Che C.M., Proteomic identification of the Cus system as a major determinant of constitutive escherichia coli silver resistance of chromosomal origin, Journal of Proteome Research. 2008, 7: 2351-2356.

 

Yip W.P., Yip W.P., Ho C.M., Zhu N., Lau T.C. and Che C.M., Homogeneous [RuIII(Me3tacn)Cl3]-Catalyzed Alkene cis-Dihydroxylation with Aqueous Hydrogen Peroxide , Chemistry - An Asian Journal. 2008, 70-77.

 

Researcher : Hu L



List of Research Outputs

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Researcher : Huang JS



Project Title:

Iron, Ruthenium, and Osmium Phosphinidene and Sulfido Complexes: Phosphorus or Sulfur Atom Transfer Reactions and Models for Native Iron-Sulfur Clusters

Investigator(s):

Huang JS

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To develop the chemistry of (1) metal-phosphorus multiple bonds in metallomacrocycles or metallosalens, (2) metal-sulfur multiple bonds in iron, ruthenium, or osmium complexes, (3) ruthenium or osmium analogues of biologically important iron-sulfur clusters. The ultimate goals are to realize metal catalyzed C P bond formation reactions such as phosphirane formation alkenes, to develop new metal cat alysts for the C-S bond formation reactions such as alkene episulfidation, and to synthesize new structural or functional models for the active sites of iron-sulfur proteins or nitrogenase.

 

Project Title:

Metalloporphyrin- and metallosalen-mediated imine functionalizations

Investigator(s):

Huang JS

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2005

 

Abstract:

The main objectives of this project are: 1) To synthesize various imine or iminato complexes of metalloporphyrins or metallosalens. 2) To study the spectral and structural properties of the imine or iminato complexes of metalloporphyrins or metallosalens. 3) To explore the reactivity of the coordinated imine or iminato ligands toward a variety of reagents such as diazo compounds, imido sources, and aryl halides. 4) To develop metalloporphyrin- or metallosalen-catalyzed aziridination, diaziridination, and N-arylation of imines.

 

Project Title:

Activation of P-H Bonds by Metalloporphyrins or Metallosalens

Investigator(s):

Huang JS

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2006

 

Abstract:

(i) To explore the reactivity of primary/secondary phosphine complexes of metalloporphyrins and metallosalens. (ii) To explore the chemistry of oxidized metalloporphyrin/metallosalen complexes of primary/secondary phosphines and examine the P-H bond activation upon oxidation. (iii) To explore the reactivity of primary/secondary phosphines with oxo, imido, and carbene complexes of metalloporphyrins. (iv) To examine the possibility of using metalloporphyrins or metallosalens as efficient catalysts for C-P bond formation reactions such as hydrophosphination.

 

Project Title:

Functionalization of Iron-, Ruthenium-, and Osmium-Sulfur Clusters with Terminal Metal-Carbene, -Imido, or -Nitrido Bonds

Investigator(s):

Huang JS

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

The main objectives of this project are: (1) To develop the chemistry of iron-, ruthenium-, and osmium-sulfur clusters bearing terminal metal-ligand multiple bonds. (2) To explore the possibility of using such types of metal-sulfur clusters as multicenter group transfer agents or catalysts for organic transformations such as cyclopropanation, aziridination, and alkene formation reactions, along with using metal-sulfur clusters bearing terminal carbene or imido groups as building blocks for larger metal-sulfur clusters or nanosized metal sulfides exhibiting unique structures and/or catalytic properties.

 

Project Title:

Metal-Sulfur Bonds Supported by Phthalocyanines

Investigator(s):

Huang JS

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

(a) To explore synthetic methods for metallophthalocyanines bearing various metal-sulfur (M-S) bonds such as M-SHR, M-SRR', M-SR, M-S-M, and M=S. (b) To investigate the spectral and structural features of M-S bonded metallophthalocyanines. (c) To explore the reactivity of M-S bonds supported by phthalocyanines. (d) To explore the application of phthalocyanine-supported M-S bonds in C-S bond formation reactions.

 

List of Research Outputs

 

Che C.M. and Huang J.S., 活性钌、锇-配体多重键配合物研究进展, 中国科学B:化学, 2008, 38: 365-395.

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Researcher : Hui SK



List of Research Outputs

 

Hui S.K., Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Funtional Study of a 9kDa a-heical Domain of BIR3-RING Linker Region in XIAP Protein by NMR Spectroscopy, Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E21.

 

Researcher : Hui YN



List of Research Outputs

 

Hui Y.N., Lin B. and Chan W.T., On-line Preconcentration for Chip-based Capillary Electrophoresis - Inductivey Coupled Plasma Atomic Emission Spectrometry Using Continuous-flow Fled-amplified Sample Stacking , Abstract of Colloquim Spectroscopic um Internationale XXXV, Ximen, China, Septermber 23-27, 2007.

 

Researcher : Jiao J



List of Research Outputs

 

Jiao J., Chen W., Leung K., Li S., Wang J., Cheung K.C. and Lin M.C., Intelligent Variable Structure Control for Automated Guided Vehicle, 2008 IEEE World Congress on Computational Intelligence (WCCI 2008); June 1-6, 2008; Hong Kong.. 2008.

 

Researcher : Ko CB



Project Title:

The mechanism of OREBP/TonEBP/NFAT5-dependent transcription - role of signaling pathway and chromatin remodeling

Investigator(s):

Ko CB, Chung SSM

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To examine the correlation between OREBP-recruitment to different promoters and the kinetics of OREBP-dependent gene expressions; to evaluate the role of histone modification in OREBP-dependent gene transcription and the role of IKK and p38 in histone phosphorylation at OREBP-dependent promoters; to investigate the role of p300/CBP in histone modification and OREBP transcription activation.

 

List of Research Outputs

 

Xu S., Wong C.L., Tong H.Y., Chung S.S.M. and Ko C.B., Phosphorylation By Casein Kinase 1 Regulates Tonicity-induced Osmotic Reponse Element-binding Protein/tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking, Journal Of Biological Chemistry. 2008, 283: 17624-34.

 

Researcher : Ko CC



List of Research Outputs

 

Li M., Ko C.C., Duan G., Zhu N. and Yam V.W.W., Functionalized Rhenium(I) Complexes with Crown Ether Pendants Derived from 1,10-Phenanthroine: Selective Sensing for Meta Ions , Organometallics. 2007, 6091-6098.

 

Researcher : Kui CF



List of Research Outputs

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Researcher : Kwok CC



List of Research Outputs

 

Che C.M., Kwok C.C., Lai S.W., Finkenzeller W., Rausch A., Yersin H. and Zhu N., Synthesis, Photophysical Properties and OLED Applications of Luminescent Platinum(II) Schiff Base Emitters, The First Asian Conference on Coordination Chemistry, Okazaki, Japan, 29 July - 2 Aug. 2007.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., 234th ACS National Meeting. 2007, Poly-319.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., Polymer Preprints (American Chemical Society, Divison of Polymer Chemistry). 2007, 48: 589 - 590.

 

Researcher : Kwok WM



Project Title:

Ultrafast time-resolved study on energy relaxation dynamics and structural properties of UV-light excited DNA bases, base derivatives and oligonucleotides

Investigator(s):

Kwok WM, Phillips DL, Ma C

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2006

 

Abstract:

(1) We propose to use our newly developed femtosecond time-resolved fluorescence (TRF) and absorption (TA) spectroscopy apparatus to perform a systematic study of natural nucleobases and selected base derivatives in solvents of different properties: Nucleic acid bases are remarkably photostable due to their ultrashort excited state lifetimes. An ultrafast nonradiative path of the singlet-excited states appears to be responsible, but the precise mechanism is unclear. The novel broadband feature of our spectroscopic techniques combined with the high sensitivity and broad time and spectral windows enable the direct spectral characterization of electronic properties of the ultrashort-lived excited states. Since the spectral character and dynamics of the relevant excited states can be modulated differently by the solvent and by specific covalent modifications, this work should generate important insights and enable us to provide a more clear and detailed description of the nonradiative pathway. (2) We propose to use ultrafast time-resolved resonance Raman (TR3) spectroscopy to directly probe the excited state structure of selected base derivatives and nucleobases and obtain this vital structural information: Besides their electronic properties, knowledge of the structural properties for excited state nucleobases is also essential for a better understanding of excited state deactivation dynamics. Previous studies have added little to our knowledge in this respect. Our results, in conjunction with the results of objective 1, should enable us to elucidate the mechanism for the ultrafast deactivation of photoexcited nucleobases, and help to resolve a continuing debate on the nature of the deactivation pathway. A further purpose of performing the fs-KTF, TA and TR3 experiments is to establish the electronic and vibrational spectral characterization for individual nucleobases. This will lay the foundations for more fruitful study of the dynamics and properties of photoexcited oligonucleotides and DNA. (3) We propose to use combined fs-TRF and TA spectroscopies to directly monitor the spectral evolution of photoexcited di- oligo- and poly- nucleotide model compounds: Previous time-resolved studies on base multimers have revealed the existence of long-lived excited states, indicating that relaxation of the electronic energy occurs on a much slower time scale than that of single bases. However, the key issues of the origin and nature of these long-lived excited states remain poorly understood. By making comparisons with the results of the relevant nucleobases, we intend to provide valuable new evidence for the elucidation of the electronic energy relaxation dynamics and excited state assignments in oligonucleotides. For explicit identification and characterization of the long-lived excited state(s) in base mulitimers, we also propose to use TR3 spectroscopy to directly probe the structure of these states in selected oligonucleotide compounds. (4) We propose to perform combined fs-TRF and TA experiments on a series of selected dinucleotides, single- and double- stranded oligo- and poly-nucleotides to explore the influence of the local environment on the excited state energy migration and relaxation dynamics: Double stranded DNAs are flexible multichromophoric systems with bases organized horizontally in base pairs and vertically in base stacks. Since the slow electronic energy relaxation occurs exclusively in base multimers where base units are stacked and/or paired, it is very important to understand how the duplex conformation mediates the energy migration and how the conformational flexibility affects the energy relaxation dynamics. These questions remain unresolved because of the lack of systematic experimental studies on the base multimer systems. We intend to identify the major factors controlling the energy relaxation process and also identify a possible spectroscopic probe to detect the unique structure of DNA. (5) Time-resolved techniques with ultrafast time-resolution are required to study the nature and dynamics of single nucleobases, oligonucleotides and DNAs because of the (ultra)short lifetime of their excited states. By performing the research necessary to achieve objectives 1-4 above, we hope to demonstrate that our newly developed ultrafast time-resolved techniques are a powerful tool for the direct detection and characterization of the rapid dynamics, electronic and structural properties and reactivity of the DNA bases and oligonucleotides following UV excitation in the solution phase. We expect that our results will greatly improve our understanding of DNA photophysics and photochemistry, and will contribute to the development of an improved molecular level mechanistic explanation for the DNA damage caused by solar UV irradiation.

 

List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Law G.L., Kwok W.M., Wong W.T., Wong K.L. and Tanner P.A., Terbium Luminescence Sensitized Through Three-Photon Excitation in a Self-assembled Unlinked Antenna , Journal of Physical Chemistry B. 2007, 111: 10858-10861.

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Ng M.C.A., Djurisic A., Tam K.H., Kwok W.M., Chan W.K., Tam W.Y., Phillips D.L. and Cheah K.W., Organic nanoclusters on inorganic nanostructures for tailoring the emission properties of organic materials, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 566-574.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Researcher : Lai PM



List of Research Outputs

 

Lai P.M., Yao H., Wong A.O.L. and Sze K.H., Structure and Functional Study of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), The Fifiennth Symposium on Chemistry Postgraduate Research in Hong Kong. The University of Hong Kong, Hong Kong, April 26, 2008.

 

Researcher : Lai SW



Project Title:

Solvatochromic Studies and Biomedical Applications of Dicyano Osmium(II) Complexes

Investigator(s):

Lai SW

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

This proposal aims to synthesize a series of cis-dicyano osmium(II) diimine complexes bearing triphenylphosphine and dimethyl sulfoxide ligands, undertake the photophysical studies and investigate their solvatochromic properties. The purpose of the proposed project is to explore the potential applications of this class of complexes as luminescent biomolecule-tagging materials. The key issues of this project are to design and synthesize luminescent osmium(II) complexes, the photophysical properties of which are effectively affected by subtle changes in the surrounding micro-environment. The solvatochromism of luminescent complexes can be thoroughly studied to enable the judicious design of luminescent osmium(II) complexes, with the aim of inducing the profound impacts upon the photoluminescent properties with changing solvent environment. The purpose of the proposed project is to integrate biomolecular binding chemistry with phosphorescence. The susceptibility of the absorption and emission energies of these luminescent dicyano osmium(II) systems to subtle changes in their micro-environments will be utilized as sensory operating principles. The metal-sensing capabilities will be explored via spectrophotometric responses. The sensitivity and selectivity towards different metal analytes will be investigated and the binding stability will also be determined. Upon derivatizing the diimine ligands with moieties bearing biomolecule-binding abilities, we intend to further utilize the sensitivity of spectrophotometric responses towards guest molecules in the applications as biomolecule-tagging materials.

 

Project Title:

Phosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications

Investigator(s):

Lai SW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

(1) This proposal aims to develop supramolecular sensory materials comprising of cyclometalated platinum(II) luminophores as reporting units and functionalized calixarene or cyclodextrin structures as host receptors. The binding motifs will be judiciously designed and incorporated to target different analytes using electrostatic, cation-pi, hydrogen bonding, or hydrophobic pi-pi interactions, and the susceptibility of the absorption and emission energies of these cyclometalated platinum(II) systems to subtle changes in their micro-environments will be utilized as sensory operating principles. The purpose of this proposal is to integrate inclusion chemistry with phosphorescence. The first objective is: To develop new classes of luminescent probes based on cyclometalated platinum(II) moieties for sensory applications. (2) The second objective is: To explore the sensing capabilities towards specific analytes by incorporating appropriate binding motifs into the luminescent receptor. Focus will be given to the conformational changes in the host structures upon inclusion of guest species. This would result in modification of the environment at the cyclometalated Pt(II) luminophoric center, which can subsequently alter the photophysical characteristics. (3) We will utilize the spectrophotometric responses of Pt(II) metallomacrocycles to develop luminescent sensory devices. The binding abilities of the receptor with guest species will be examined structurally using X-ray crystallography. The selectivity towards various analytes will be investigated, and the binding capacities will be estimated by computational calculations. The third objective is: To determine the sensitivity and selectivity of metal-functionalized host structures towards various substrates based on their spectrophotometric responses. (4) The fourth objective is: To develop self-assembly processes as efficient methodologies for the construction of metallomacrocycles. An overall aim is to probe the binding mechanisms of luminophoric macrocycles and to develop novel applications as sensory devices, especially for biological systems. In particular, the development of water-soluble luminescent derivatives which can function as robust sensory materials for molecular recognition and identification of biologically important molecules will be targeted. The significance of this research proposal stems from the implementation of collaborative and interdisciplinary research in the area of photoluminescent biomoleculer sensory technology.

 

Project Title:

Photoluminescence Studies of Silver(I) Complexes and Applications as Chemosensors

Investigator(s):

Lai SW

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

This proposal aims to synthesize closed-shell silver(I) complexes with different coordination geometry, undertake the photophysical studies, and manifest the susceptibility of photoluminescence changes towards coordination environment at the metal center. The purpose of the proposed project is to explore the potential applications of this class of complexes as chemosensors based on our understandings in their fundamental photoluminescence studies. The key issues of this project are to design and synthesize organic ligand systems with structurally rigid framework, which upon complexation with silver ions, the metal centers will be effectively encased or sandwiched by chelates to result in metal-organic species with improved rigidity, thermal stability and robustness. The photophysical properties of the closed-shell metal complexes are effectively affected by ligand systems and coordination environment of the metal center. The susceptibility of photoluminescent properties of these closed-shell metal complexes towards coordination environment will provide optical signal “read-out” units in the development of sensory applications. The purpose of the proposed project is to build up our understandings in the fundamental photoluminescence studies of closed-shell d10 metal complexes, which will in future facilitate the elaboration of these optical responses into systems with chemosensory applications. The binding capabilities of proposed luminescent sensors will be explored via spectrophotometric responses. The sensitivity and selectivity towards different analytes will be investigated and the binding stability will also be determined.

 

List of Research Outputs

 

Che C.M., Kwok C.C., Lai S.W., Finkenzeller W., Rausch A., Yersin H. and Zhu N., Synthesis, Photophysical Properties and OLED Applications of Luminescent Platinum(II) Schiff Base Emitters, The First Asian Conference on Coordination Chemistry, Okazaki, Japan, 29 July - 2 Aug. 2007.

 

Lai S.W., Chan K.W.Q., Zhu N. and Che C.M., cis-Dicyanoosmium(II) Diimine Complexes Bearing Phosphine or Sulfoxide Ligands: Spectroscopic and Luminescent Studies, Inorganic Chemistry. Washington, D.C., American Chemical Society, 2007, 46: 11003-11016.

 

Xiang H., Lai S.W., Lai P.T. and Che C.M., Phosphorescent Platinum(II) Materials for OLED Applications, In: Hartmut Yersin, Highly Efficient OLEDs with Phosphorescent Materials. John Wiley & Sons (Asia) Pte. Ltd., 2007.

 

Researcher : Lam CF



List of Research Outputs

 

de Montigny F., Argouarch G., Roisnel T., Toupet L., Lapinte C., Lam C.F., Tao C.H. and Yam V.W.W., Syntheses, Structures, and Properties of Some Piano-stool Iron Acetylides Bearing a Functional Anthracenyl Group, Organometallics. 2008, 27: 1912-1923.

 

Researcher : Lam NW



List of Research Outputs

 

Laskin J., Yang Y., Lam N.W. and Chu I.K., Charge-Remote Fragmentation of Odd-Electron Peptide Ions, Analytical Chemistry. 2007, 79: 6607-6614.

 

Researcher : Lam SK



List of Research Outputs

 

Chiu P., Lam S.K. and Leung L.T., Studies Toward the Asymmetric Synthesis of Secodolastanes and Dolastanes: Indicol and Dolatriol , The 40thNational Organic Symposium, Duke University, North Carolina, U.S.A., June 3-7, 2007. Poster A52.

 

Chiu P., Lam S.K. and Leung L.T., Synthesis Studies on Secodolastnes and Dolastanes: Indicol and Dolatriol, The 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Korea, September 2. 2007.

 

Chung W.K., Lam S.K., Lo B.T.K. and Chiu P., [4+3] Cycloadditions Using Epoxy Enol Silanes as Oxyallyl Cation Precursors , The 18th IUPAC International Conference on Organic Synthesis, Korea, June 22. 2008.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis (-) - Indicol by a Carbene Cyclization-Cycloaddtion Cascade Strategy, Chemistry – A European Journal. Wiley, 2007, 13: 9589-9599.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis of (-) –Indicol by a Carbene Cyclization – Cycloaddition Cascade Strategy , Chemistry - A European Journal. 2007, 13: 9589-9599.

 

Researcher : Lam SK



List of Research Outputs

 

Chiu P., Lam S.K. and Leung L.T., Studies Toward the Asymmetric Synthesis of Secodolastanes and Dolastanes: Indicol and Dolatriol , The 40thNational Organic Symposium, Duke University, North Carolina, U.S.A., June 3-7, 2007. Poster A52.

 

Chiu P., Lam S.K. and Leung L.T., Synthesis Studies on Secodolastnes and Dolastanes: Indicol and Dolatriol, The 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Korea, September 2. 2007.

 

Chung W.K., Lam S.K., Lo B.T.K. and Chiu P., [4+3] Cycloadditions Using Epoxy Enol Silanes as Oxyallyl Cation Precursors , The 18th IUPAC International Conference on Organic Synthesis, Korea, June 22. 2008.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis (-) - Indicol by a Carbene Cyclization-Cycloaddtion Cascade Strategy, Chemistry – A European Journal. Wiley, 2007, 13: 9589-9599.

 

Lam S.K. and Chiu P., Asymmetric Total Synthesis of (-) –Indicol by a Carbene Cyclization – Cycloaddition Cascade Strategy , Chemistry - A European Journal. 2007, 13: 9589-9599.

 

Researcher : Lam SWH



Project Title:

Electronic Structures, Photophysical Properties and Reactivities of Photochromic Transition Metal Complexes With Coordination of Ligand(s) Containing the Diarylethene Unit(s). A Computational Study

Investigator(s):

Lam SWH, Yam VWW

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

The aims of this research are 1) to investigate electronic structures as well as spectroscopic origins of the absorption and emission properties of the photochromic complexes and find out the factors influence the stability of the open and closed forms by density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations. The calculated results are then used to rationalize experiemental observations, which provide a better understanding on their structural and photophysical properties; 2) to study mechanisms for the photochromic reactions by using DFT and high-lvele ab initio calculations, that provide a better understanding on the quantum yields of the reactions.

 

List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Lam S.W.H., Cheng C.C. and Yam V.W.W., Computational Studies on the Photophysical Properties and NMR Fluxionality of the Tetranuclear Copper(I) Complexes [Cu4(m-dppm)(m4-E]2+(E= PPh and S) , 234th ACS Meeting . 2007, INOR-733.

 

Tam Y.Y., Lam S.W.H., Wong M.C., Zhu N. and Yam V.W.W., Luminescent Alkynylplatinum(II) Complexes of 2,6-Bis (N-alkylbenzimidazol-2'-yl) Pyridine-Type Ligands with Ready Tunability of the Nature of the Emissive States by Solvent and Electronic Property Modulation , Chemistry - A European Journal. 2008, 14: 4562-4576.

 

Researcher : Lau CY



List of Research Outputs

 

Lau C.Y., Reductive Alodl Cyclizations Using Stryker's Reagent and Polystyrene-Supported Triphenylarsine in Carbon-Carbon Bond Forming Reactions (PhD Thesis) . 2008.

 

Researcher : Lau JPK



List of Research Outputs

 

Lau J.P.K., Gu Y. and Wong W.T., High-yield Synthesis of a New layered High-nuclearity Carbonyl Osmium-rhodium Cluster Complex -- Synthesis Structural Characterization, and Electrochemistry of [PPN][Os9Rh3(m-CO)2(CO)26], European Journal of Inorganic Chemistry. 2007, 3011-3014.

 

Researcher : Lau KK



List of Research Outputs

 

Law G.L., Wong K.L., Lau K.K., Tam H.L., Cheah K.W. and Wong W.T., Synthesis, Crystal Structures, and Photophysical Properties of Lanthanide Complexes Containing Pyrrole-derivatized Carboxylate Ligands , European Journal of Inorganic Chemistry. 2007, 34: 5419-5425.

 

Researcher : Law GL



List of Research Outputs

 

Fan H.H., Wu K.S., Wang H.Z., Tian Y.P., Law G.L., Wong K.L. and Wong W.T., Effective Multi-photon Absorption Properties in Solutions of Pyridinium Salt Lasing Dyes , Chemical Physics Letters. 2007, 449: 77-81.

 

Law G.L., Wong K.L., Man C.W.Y., Wong W.T., Tsao G.S.W., Lam M.H.W. and LAM P.K.S., Emissive Terbium Probe for Multiphoton in Vitro Cell Imaging , Journal of the American Chemical Society. 2008, 130: 3714-3715.

 

Law G.L., Wong K.L., Yang Y.Y., Yi Q.Y., Jia G.H., Wong W.T. and Tanner P.A., Structural Characterization of Shielded Isomeric Europium Complexes with Metal-metal Contact , Inorganic Chemistry. 2007, 46: 9754-9759.

 

Law G.L., Synthesis and Photophysical Studies of Organic Lanthanide Complexes (PhD Thesis) . 2007.

 

Law G.L., Wong K.L., Lau K.K., Tam H.L., Cheah K.W. and Wong W.T., Synthesis, Crystal Structures, and Photophysical Properties of Lanthanide Complexes Containing Pyrrole-derivatized Carboxylate Ligands , European Journal of Inorganic Chemistry. 2007, 34: 5419-5425.

 

Law G.L., Kwok W.M., Wong W.T., Wong K.L. and Tanner P.A., Terbium Luminescence Sensitized Through Three-Photon Excitation in a Self-assembled Unlinked Antenna , Journal of Physical Chemistry B. 2007, 111: 10858-10861.

 

Wong K.L., Law G.L., Murphy M.B., Tanner P.A., Wong W.T., Lam P.K.S. and Lam M.H.W., Functionalized Europium Nanorods for In Vitro Imaging , Inorganic Chemistry. 2008, 47: 5190-5196.

 

Researcher : Law GL



List of Research Outputs

 

Fan H.H., Wu K.S., Wang H.Z., Tian Y.P., Law G.L., Wong K.L. and Wong W.T., Effective Multi-photon Absorption Properties in Solutions of Pyridinium Salt Lasing Dyes , Chemical Physics Letters. 2007, 449: 77-81.

 

Law G.L., Wong K.L., Man C.W.Y., Wong W.T., Tsao G.S.W., Lam M.H.W. and LAM P.K.S., Emissive Terbium Probe for Multiphoton in Vitro Cell Imaging , Journal of the American Chemical Society. 2008, 130: 3714-3715.

 

Law G.L., Wong K.L., Yang Y.Y., Yi Q.Y., Jia G.H., Wong W.T. and Tanner P.A., Structural Characterization of Shielded Isomeric Europium Complexes with Metal-metal Contact , Inorganic Chemistry. 2007, 46: 9754-9759.

 

Law G.L., Synthesis and Photophysical Studies of Organic Lanthanide Complexes (PhD Thesis) . 2007.

 

Law G.L., Wong K.L., Lau K.K., Tam H.L., Cheah K.W. and Wong W.T., Synthesis, Crystal Structures, and Photophysical Properties of Lanthanide Complexes Containing Pyrrole-derivatized Carboxylate Ligands , European Journal of Inorganic Chemistry. 2007, 34: 5419-5425.

 

Law G.L., Kwok W.M., Wong W.T., Wong K.L. and Tanner P.A., Terbium Luminescence Sensitized Through Three-Photon Excitation in a Self-assembled Unlinked Antenna , Journal of Physical Chemistry B. 2007, 111: 10858-10861.

 

Wong K.L., Law G.L., Murphy M.B., Tanner P.A., Wong W.T., Lam P.K.S. and Lam M.H.W., Functionalized Europium Nanorods for In Vitro Imaging , Inorganic Chemistry. 2008, 47: 5190-5196.

 

Researcher : Law KL



List of Research Outputs

 

Law K.L., Synthesis of Spirolactams via Phenylseleno Group Transfer Radical Cyclization and Secondary Amine Formation via Reductive Amination Using InCl3/Et3SiH Promoted by Lewis Acid (PhD Thesis). 2007.

 

Researcher : Law YC



List of Research Outputs

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Researcher : Lee KM



List of Research Outputs

 

Yu S.Y., Sun Q.F., Lee K.M., Cheng C.C., Li Y.Z. and Yam V.W.W., Au36 Crown: A Macrocyclization Directed by Metal-Metal Bonding Interactions , Angewandte Chemie International Edition. 2008, 47: 4551-4554.

 

Researcher : Lee KW



List of Research Outputs

 

Lee K.W., Deign, Synthesis, Photophysis and Photochromic Study of Dithienylethene-containing N-Heterocycles and Their d8 and 10 Metal Complexes (PhD Thesis) . , 2007.

 

Researcher : Lee OY



List of Research Outputs

 

Lee O.Y., Synthesis of Heterocycles Via Phenylesleno Group Transfer Radical Cyclization and Chemoselective Reductive Amination Promoed by InCl3 (PhD Thesis) . 2007.

 

Researcher : Lee YB



List of Research Outputs

 

Lee Y.B. and Wong W.T., Iridium Insertion to Triosmium Cluster Containing Unsaturated Os-Os Bonds , Journal of Cluster Science. 2008, 19: 133-145.

 

Lee Y.B. and Wong W.T., New Triosmium-iridium Clusters: Synthesis and Molecular Structure of [Os3Ir2(Cp*)2(m-OH) (m-CO)2(CO)8Cl](1), [Os3IrCp*(m-OH)(CO)10Cl](2), [Os3IrCp*(m-H)(m-Cl)(h3, m3-C5H2N(NH2Br))(CO)9](3) and[Os3IrCp*(m-Cl)2(h2, m3-C5H3N(NH)Br)(CO)7](4), In: , Journal of Organometallic Chemistry . 2008, 693: 1528-1535.

 

Lee Y.B. and Wong W.T., Synthesis and Characterisation of High-nuclearity Osmium-silver Mixed-metal Clusters , Chemical Communications. 2007, 3924-3926.

 

Researcher : Lei T



List of Research Outputs

 

He Q., Zhu R., Lei T., Ng M.Y.M., Luk J.M.C., Sham P.C., Lau G. and Chiu J., Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma, Journal of Cellular Biochemistry. 2008, 103: 740-752.

 

Researcher : Leung CH



List of Research Outputs

 

Park S.Y., Leung C.H. and Cheng Y.C., ATP Modulates Poly(ADP-Ribose) Polymerase-1-Facilitated Topoisomerase I-Linked DNA Religation in the Presence of Camptothecin , Molecular Pharmacology . 2008, 1829-1837.

 

Researcher : Leung LT



List of Research Outputs

 

Chiu P., Lam S.K. and Leung L.T., Studies Toward the Asymmetric Synthesis of Secodolastanes and Dolastanes: Indicol and Dolatriol , The 40thNational Organic Symposium, Duke University, North Carolina, U.S.A., June 3-7, 2007. Poster A52.

 

Chiu P., Lam S.K. and Leung L.T., Synthesis Studies on Secodolastnes and Dolastanes: Indicol and Dolatriol, The 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Korea, September 2. 2007.

 

Researcher : Leung LT



List of Research Outputs

 

Chiu P., Lam S.K. and Leung L.T., Studies Toward the Asymmetric Synthesis of Secodolastanes and Dolastanes: Indicol and Dolatriol , The 40thNational Organic Symposium, Duke University, North Carolina, U.S.A., June 3-7, 2007. Poster A52.

 

Chiu P., Lam S.K. and Leung L.T., Synthesis Studies on Secodolastnes and Dolastanes: Indicol and Dolatriol, The 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Korea, September 2. 2007.

 

Researcher : Leung QY



List of Research Outputs

 

Leung Q.Y., Mak S.K., Tam W.Y. and Chan W.K., Fabrication of Rhenium Containing Narrow Band Gap Polymer for Photovoltaic Applications , Abstract of Europolymer Confernece, 2008, Gargnano (BS-Italy), June 1-5, 2008. Gargnano, Italy, Poster ref. P.30.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Researcher : Leung WH



List of Research Outputs

 

Li L., Leung W.H., Cheung A.S.C., Liu B.S. and Au C.T., Ch4/co2 Refforming Over La2nio4 And 10%nio/ceo2-la2o3 Catalysts Under The Condition Of Supersonic Jet Expansion Via Cavity Ring-down Spectroscopic Analysis, Catalysis Today. Elsevier, 2008, 131: 533.

 

Pang H.F., Ye J., Leung W.H., Chen G. and Cheung A.S.C., Experimental and Theoretical Studies of Diatomic Iridium Compounds , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16,. 2008, MF12.

 

Ye J., Pang H.F., Wong M.Y., Leung W.H. and Cheung A.S.C., Laser Spectroscopy of Iridium Monoboride , The Journal of Chemical Phyics. 2008, 128: 154321-1 - 154321-6.

 

Researcher : Leung YH



List of Research Outputs

 

Pandey A.K., Nunzi J.M., Wang H., Oey C.C., Djurisic A., Xie M.H., Leung Y.H., Man K.K.Y. and Chan W.K., Reverse biased annealing: Effective post treatment tool for polymer/nano-composite solar cells, Organic Electronics. Amsterdam, Elsevier B.V., 2007, 8: 396-400.

 

Researcher : Li C



List of Research Outputs

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Li C., Total Syntheses of (-)-5-Demthoxyfumagillol, (-)-Fumagillol, (-)-RK-805, (-)-FR65814 and Analogues (PhD Thesis) . 2008.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Li C



List of Research Outputs

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Li C., Total Syntheses of (-)-5-Demthoxyfumagillol, (-)-Fumagillol, (-)-RK-805, (-)-FR65814 and Analogues (PhD Thesis) . 2008.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Li H



List of Research Outputs

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Li H., Gu J.D. and Sun H., Structure, topology and assembly of a 32-mer peptide corresponding to the loop 3 and transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environments, Journal of Inorganic Biochemistry . 2008, 102: 1257-1266.

 

Li H., Sze K.H. and Sun H., Validation Inter-helical Orientation of the Sterile-a-Motif Domain of the Delected in Liver Cancer 2(DLC2-SAM) by Residual Couplings , International Comferene in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A18.

 

Wang H., Li H., Cai B., Huang Z. and Sun H., The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein, Journal of Biological Inorganic Chemistry. 2008, 13: 411-419.

 

Yang Z., Wang X., Diao H., Zhang J., Li H., Sun H. and Guo J., Encapsulation of platinum anticancer drugs by apoferritin, Chemical Communications. 2007, 3453-3455.

 

Researcher : Li HY



List of Research Outputs

 

Li H.Y., Chau D.H.W., Gao Y., Ng S.M. and Lin M.C., Genome-wide Expression Profiling Reveals the Multiple Signaling Pathways Modulated by rAdv-hTERTC27 Treatment in Glioblastoma Multiforme, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Researcher : Li KLC



List of Research Outputs

 

Li K.L.C., In Vitro and in Vivo Studies of Cytotoxic and Anti-angiogenic Cyclometalated Gold(III) and Gold(III) Prophyrin Complexes (PhD Thesis) . 2008.

 

Researcher : Li L



List of Research Outputs

 

Li L., Catalytic Methane Reformation and Aromatization Reaction Studies via Cavity Ringdown Spectroscopy and Time of Flight Mass Spectrometry (PhD Thesis) . 2008.

 

Li L., Leung W.H., Cheung A.S.C., Liu B.S. and Au C.T., Ch4/co2 Refforming Over La2nio4 And 10%nio/ceo2-la2o3 Catalysts Under The Condition Of Supersonic Jet Expansion Via Cavity Ring-down Spectroscopic Analysis, Catalysis Today. Elsevier, 2008, 131: 533.

 

Liu B., Au C.T., Li L. and Cheung A.S.C., Methane Aromatization Over 3 Percent Mo/HZSM-5 Catalyst Investigated by TOF-MS Under Supersonic Jet Expansion Condition , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16-20, . 2008, TJ3.

 

Researcher : Li M



List of Research Outputs

 

Li M., Chen Z., Zhu N., Yam V.W.W. and Zu Y., Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cations Binding , Inorganic Chemistry. 2008, 1218-1223.

 

Li M., Ko C.C., Duan G., Zhu N. and Yam V.W.W., Functionalized Rhenium(I) Complexes with Crown Ether Pendants Derived from 1,10-Phenanthroine: Selective Sensing for Meta Ions , Organometallics. 2007, 6091-6098.

 

Li M., Chen Z., Yam V.W.W. and Zu Y., Multifunctional Ruthenium (II) Polypyridine Complex-Based Core-Shell Magnetic Silica Nanocomposites: Magnetism, Luminescence, and Electrochemiluminescence , ACS Nano. 2008, 2: 905-912.

 

Researcher : Li S



List of Research Outputs

 

Li S. and Chiu P., Acid-promoted Sequential Cationic Cyclizations for the Synthesis of (±) -Taiwaniaquinol B, Tetrahedron Letters. 2008, 49: 1741-1744.

 

Researcher : Li X



List of Research Outputs

 

Li X., Neural Network Based Exchanced-correlation Functional (MPhil Thesis) . 2008.

 

Li X., Using Alpha-aminoxy Acids as Building Blocks to Construct Anion Receptors and Synthetic Chloride Channels (PhD Thesis) . 2008.

 

Researcher : Li X



List of Research Outputs

 

Li X., Neural Network Based Exchanced-correlation Functional (MPhil Thesis) . 2008.

 

Li X., Using Alpha-aminoxy Acids as Building Blocks to Construct Anion Receptors and Synthetic Chloride Channels (PhD Thesis) . 2008.

 

Researcher : Li Z



List of Research Outputs

 

Sun H., Yam W.C., Ng S.P., Li Z. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Detection of E. Coli in Environmental Water , Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007 . 2007, p41, pp71.

 

Researcher : Lin B



List of Research Outputs

 

Hui Y.N., Lin B. and Chan W.T., On-line Preconcentration for Chip-based Capillary Electrophoresis - Inductivey Coupled Plasma Atomic Emission Spectrometry Using Continuous-flow Fled-amplified Sample Stacking , Abstract of Colloquim Spectroscopic um Internationale XXXV, Ximen, China, Septermber 23-27, 2007.

 

Researcher : Lin MC



Project Title:

Basic research on systemic damage in early stage and wound-healing after severe trauma

Investigator(s):

Lin MC

Department:

Institute of Molecular Biology

Source(s) of Funding:

Matching Fund for National Key Basic Research Development Scheme (973 Projects)

Start Date:

04/2001

 

Abstract:

To study basic research on systemic damage in early stage and wound-healing after severe trauma.

 

Project Title:

Basic research on the mechanism of aging and the prevention of geriatric disease

Investigator(s):

Lin MC

Department:

Institute of Molecular Biology

Source(s) of Funding:

Matching Fund for National Key Basic Research Development Scheme (973 Projects)

Start Date:

12/2001

 

Abstract:

To study the mechanism of aging and the prevention of geriatric disease.

 

Project Title:

Characterization of a novel cell cycle related kinase in glioblastoma

Investigator(s):

Lin MC, Leung SY, Ching YP

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2002

 

Abstract:

The project aims at characterizing the role of cell cycle related kinase (CCRK) in cell cycle control, apoptosis, cell division and cell proliferation. Potential tumorigenic function of CCRK in human glioblastoma, fibroblast cell lines, and nude mice xenograft will also be investigated.

 

Project Title:

Molecular basis of alcohol-induced birth defects, the critical role of Pax 6

Investigator(s):

Lin MC, Wong BCY, Yang JY, Peng Y

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To elucidate the signaling pathways leading to alcohol-mediated inhibition of Pax6 expression and to identify the targets downstream of Pax6 responsible for microcephaly. We are particularly interested in the involvements of the PI3 kinase pathways and the reactive oxygen species and reactive nitrogen species; to investigate the molecular mechanisms for alcohol-induced growth retardation, in particular its relationship with gut development; to study alcohol induced eye deformation; to screen for agents that protect against alcohol induced birth defects.

 

Project Title:

Characterization of HNF-1 Cis-element as a novel insulin negative responsive element and identification of a new anti-diabetic drug targeting this element

Investigator(s):

Lin MC, Lu L, Tam S

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To determine if the consensus HNF-1 element also displays negative insulin responsiveness; to determine the role of HNF1α versus HNF1β and mutant HNF-1α in this transcription regulation; to evaluate the therapeutic effects / molecular mechanisms of a new anti-diabetic drug targeting this INRE.

 

Project Title:

System biology study of a novel anti-angiogenesis polypeptide kringle 1 domain of hepatocyte growth factor

Investigator(s):

Lin MC, Yiu SM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Kringle domain, a protein module consists of 80 amino acids, function as recognition units for binding of other proteins in solution and on cells. Several of the kringle domain peptide including Angiostatin has been shown to exhibit anti-angiogenesis effect. Recently, my laboratory studied the cancer therapeutic effect of a novel anti-angiogenesis polypeptide, kringle 1 domain of human hepatocyte growth factor (HGFK1). We demonstrated that using a recombinant adeno-associated virus (AAV) carrying the HGFK1 gene (rAAV-HGFK1), we can significantly inhibited the proliferation, migration, and vessel tube formation of mice microvascular endothelial cells in vitro. More importantly, in an in vivo preclinical study conducted in rat orthotropic model of hepatocellular carcinoma (HCC), we showed that rAAV-HGFK1 is more potent than rAAV-Endostatin, the leading anti-angiogenesis gene, in prolonging the survival rate of the tumor bearing rats. Furthermore, rAAV-HGFK1 effectively inhibits tumor growth and metastasis. The objectives of the research proposal is to elucidate the molecular mechanisms underlie the anti-angiogenesis effect of HGFK1 polypeptide using System Biology approach, which will use bioinformatics to integrate data obtained from cDNA microarray experiments, Yeast two hybrid and Proteomic study. Multiple anti-angiogenesis molecules with different efficacies have been identified, however their underlying molecular mechansims remain elusive. These molecules potentially exert their effects through different signal pathways, with different interacting proteins and downstream targets. Information gained from this study will allow us to compare the molecular mechanisms of HGFK1 to that of the current leading anti-angiogenesis polypeptide Endostatin which has recently been reported using similar approaches (Abdollahi, A et al. Molecular Cell 13: 649-663, 2004).

 

Project Title:

Integrative Cancer Biology: Study the Novel Function of Makorin-2 in Colon Cancer Carcinogenesis

Investigator(s):

Lin MC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

Many of the developmental genes also play important roles in carcinogenesis. Makorin-2 (HSPC070), originally isolated from hematopoietic stem/progenitor cells, belongs to the makorin family of genes that encode putative ribonucleoproteins. The function of makorin-2 is not known. We have recently shown that Xenopus Makorin-2 (Xmakorin-2) is expressed throughout embryonic development. Embryos over-expressing Xmakorin-2 mRNA exhibited enhanced ventralization and knockdown of Xmakorin-2 caused embryonic death. We further showed that expression of Xmakorin-2 induced hematopoietic markers α-globin and GATA-1. As such, knockdown of Xmakorin-2 suppressed the expressions of α-globin and GATA-2. Furthermore, knockdown of Xmakorin-2 completely blocked BMP-4 induced α-globin expression. These results suggest for the first time that Xmakorin-2 plays an important role in BMP-4 signaling during Xenopus embryonic development (manuscript in preparation). Makorin-2 is characterized by a variety of zinc-finger motifs. To date, nine makorin family loci have been identified and located throughout the human genome [1]. Makorin-2, located on chromosome 3p25, contains 8 exons and its nucleotide sequence shares a sequence of 105bp in 3' UTR with the oncogene c-RAF gene in reversed transcription orientation [2], suggesting that these two proteins may regulate each other. Northern blot analysis showed that makorin-2 was expressed in a variety of tissues, as well as in many of the cancer cell lines examined [2]. These raised the possibility that makorin-2 may have important roles in carcinogenesis. The objective is to use integrative cancer biology approaches to explore the potential role of makorin-2 in carcinogenesis. To achieve this aim, we conducted bioinformatics analysis. From the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/), a public repository for microarray gene expression data, we found that makorin-2 was significantly upregulated by > 4-fold in metastatic colon cancer cell line SW620, as compared to primary tumor colon cancer cell line SW480 (Fig. 1). This finding suggests that makorin-2 may involve in colon cancer progression (GEO accession number GDS756). References: 1. Gray TA, Hernandez L, Carey AH, Schaldach MA, Smithwick MJ, Rus K, Marshall Graves, JA, Stewart CL, Nicholls RD. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics 2000;66:76-86. 2. Gray TA, Azama K, Whitmore K, Min A, Abe S, Nicholls RD. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene. Genomics 2001;77:119-26.

 

List of Research Outputs

 

Chen Y., Lin M.C., Yao H., Wang H., Zhang A.Q., Yu J., Hui C.K., Lau G., He M.L., Sung J. and Kung H.F., Lentivirus-mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-regulation of Stathmin (Erratum in: Hepatology. 2007 Oct;46(4):1314), Hepatology. 2007, 46(1): 200-208.

 

Chen Y., Lin M.C., Wang H., Chan C.Y., Jiang L., Ngai S.M., Yu J., He M.L., Shaw P.C., Yew D.T., Sung J.J. and Kung H.F., Proteomic Analysis of EZH2 Downstream Target Proteins in Hepatocellular Carcinoma, Proteomics. 2007, 7(17): 3097-3104.

 

Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, The Eighth International Conference on Systems Biology; 1-6 October, 2007; California, USA. . 2007.

 

Cheung K.C., Zhu S. and Lin M.C., Signaling Network of MIF Knockdown in Inhibiting Tumor Growth and Metastasis in Gastric and Colorectal Cancers, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Du L., Chen J., Qi Y., Li D., Yuan C., Lin M.C., Yew D.T., Kung H.F., Yu J.C. and Lai L., Preparation and Biomedical Application of a Non-polymer Coated Superparamagnetic Nanoparticle, International Journal of Nanomedicine. 2008, 2: 805-12.

 

Jiao J., Chen W., Leung K., Li S., Wang J., Cheung K.C. and Lin M.C., Intelligent Variable Structure Control for Automated Guided Vehicle, 2008 IEEE World Congress on Computational Intelligence (WCCI 2008); June 1-6, 2008; Hong Kong.. 2008.

 

Leung W.S., Lin M.C., Cheung D.W.L. and Yiu S.M., A Clustering-Based Approach for Filtering False Positive MicroRNA Candidates, 4-th International Symposium on Bioinformatics Research and Applications; May 6-9, 2008; Department of Computer Science, Georgia State University; Atlanta, Georgia (Lecture Notes in Bioinformatics (LNBI)). 2008.

 

Leung W.S., Shen Z., Yiu S.M., Kung H.F. and Lin M.C., Characterization of HGFK1 Signaling Networks in Microvessel Endothelial and Hepatoma Cell Lines, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong. 2007.

 

Leung W.S., Yiu S.M., Cheung D.W.L., Lai L., Lin M.C. and Kung H.F., Computational Prediction on Mammalian and Viral MicroRNAs - a Review, International Journal of Integrative Biology. 2007, 1(2): 118-126.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Li H.Y., Chau D.H.W., Gao Y., Ng S.M. and Lin M.C., Genome-wide Expression Profiling Reveals the Multiple Signaling Pathways Modulated by rAdv-hTERTC27 Treatment in Glioblastoma Multiforme, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Li Z., Yao H., Ma Y., Dong Q., Peng Y., Zheng B., Huang J., Chan C.Y., Lin M.C., Sung J.J., Yuen K.Y., Kung H.F. and He M.L., Inhibition of HBV gene expression and replication by stably expressed interferon-α1 via adeno-associated viral vectors, J Gene Med.. 2008, 10(6): 619-627.

 

Lin M.C., Development of Novel Cancer Gene Therapy, The Nanjing International Symposium of New Frontiers in Cancer Research; 9-10 Nov 2007; Nanjing, China. 2007.

 

Lin M.C., Functional Genomics and Gene Therapy, Kunming University of Medical Sciences; 11 Jul, 2007.. 2007.

 

Lin M.C., Kringle 1 Domain of HGF Exhibits Dual Anti-tumor and Antiangiogenic Effects Through EGF/EFGR Pathway, The 2007 Annual Conference of the International Society for Cell and Gene Therapy of Cancer; 16-18 November, 2007; Mumbai, India , 2007 . 2007.

 

Lin M.C., Member of Scientific Committee, The 2007 Annual Conference of the International Society for Cell and Gene Therapy of Cancer; 16-18 November, 2007; Mumbai, India . 2007.

 

Liu C.C. and Lin M.C., Screening of TCM as Transcription Inhibitors of MTP Gene, 2nd International Conference on Hypertension, Lipids, Diabetes and Stroke Prevention; Prague, Czech Republic; March 6-8, 2008. . 2008.

 

Ng S.M., Yang P., Cheng Y., Peng Y., Kung H.F. and Lin M.C., Differential and Critical Roles of Reactive Oxygen Species and Reactive Nitrogen Species in Alcohol-Induced Gene Dysregulations and Birth Defects in Xenopus Embryos, Neuroembryology and Aging. 2007, 4: 155-161.

 

Qi Y., Chen X., Chan C.Y., Li D., Yuan C., Yu F., Lin M.C., Yew D.T., Kung H.F. and Lai L., Two-dimensional Differential Gel Electrophoresis/analysis of Diethylnitrosamine Induced Rat Hepatocellular Carcinoma, International Journal of Cancer. 2008, 122(12): 2682-8.

 

Shen Z., Yang Z., Gao Y., Li J.C., Chen H.X., Liu C.C., Poon R.T.P., Fan S.T., Luk J.M.C., Sze K.H., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Cancer Research. 2008, 68: 404-414.

 

Shen Z., Leung W.S., Yiu S.M., Kung H.F. and Lin M.C., The Molecular Mechanisms of the Dual Anti-angiogenic and Anti-tumor Effects of rAAV-HGFK1, 11th Annual Meeting of the American Society of Gene Therapy May 28-June 1, 2008; Boston, Massachusetts, USA.. 2008.

 

Shi X., Lin J., Peng Y., Chan L.L.Y., Kung H.F., Lin M.C. and Huang R., Artificial Cold Exposure Induced Stroke in Renovascular Hypertensive Rats and its Association with Cold-inducible RNA Binding Protein mRNA Expression in Brain Tissue and Blood Pressure, Neural Regeneration Research. 2007, 2: 455-60.

 

Sun Y., Qiao L., Zou B., Xia H.H.X., Gu Q., Ma J., Lin M.C., Zhu Q., Zhu S., Dai Y. and Wong B.C.Y., Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells, Digestion. 2008, 77: 79-86.

 

Sun Y., Qiao L., Xia H.H.X., Lin M.C., Zou B., Yuan Y., Zhu S., Gu Q., Cheung T.K., Kung H.F., Yuen R.M.F., Chan A.O.O. and Wong B.C.Y., Regulation of XAF1 Expression in Human Colon Cancer Cell by Interferon β: Activation by the Transcription Regulator STAT1, Cancer Letters. 2008, 260: 62-71.

 

Wang X.Y., Lai Z.S., Yeung C.M., Wang J.D., Deng W., Hang Y.J., Kung H.F., Jiang B. and Lin M.C., Establishment and Characterization of a New Cell Line Derived from Human Colorectal Laterally Spreading Tumor , World Journal of Gastroenterology. 2008, 14(8): 1204-1211.

 

Yang N., Tanner J.A., Zheng B., He M.L., Lu L., Jiang J.Q., Shum K.T., Lin Y., Wong K.L. and Lin M.C., Bismuth Complexes Inhibit the SARS Coronvirus, Angew. Chem. Int. Ed. 2007, 46: 6464.

 

Yang N., Tanner J.A., Zheng B., Watt R.M., He M.L., Lu L., Jiang J., Shum K.T., Lin Y., Wong K.L., Lin M.C., Kung H.F., Sun H. and Huang J., Bismuth complexes inhibit the SARS coronavirus, Angewandte Chemie International Edition. 2007, 46: 6464-6468.

 

Yang P., Cheung K.C., Peng Y., He M.L., Wu G., Xie D., Jiang B., Huang Q., Chen Z., Lin M.C. and Kung H., Makorin-2 is a Neurogenesis Inhibitor Downstream of PI3K/AKT Signal , The Journal of Biological Chemistry. 2008, 283: 8486-8495.

 

Yeung C.M., Tan Y., Tam S., Lu L., Ko K.H., Yang P., Kung H.F. and Lin M.C., The Antidiabetic Effects of a Dry Powder of Dietary Vegetable and Fruit Mixtures in Diabetic db/db Mice, Biologics: Targets and Therapy. 2008, 2(3): 571-576.

 

Yeung H.Y., Wong K.Y., Lin M.C., Wong C.K., Mashima T., Tsuruo T. and Wong A.S.T., Chemosensitization by Manganese Superoxide Dismutase Inhibition is Caspase-9 Dependent and Involves Extracellular Signal-regulated Kinase 1/2, British Journal of Cancer. 2008, 99: 283-293.

 

Researcher : Lin W



List of Research Outputs

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Researcher : Lin X



List of Research Outputs

 

Guo Z., Lin X., Zhao C. and Phillips D.L., Density Functional Theory Study of Water-assisted Deprotonation of the C8 Intermediate in the Reaction of the 2-Fluorenylnitrenium Ion with Guanosine to form a C8 Adduct, Journal of Molecular Structure: THEOCHEM. 2008, 848: 119-127.

 

Lin X., Zhao C., Che C.M., Ke Z.F. and Phillips D.L., A DFT Study on the Mechanism of Rh2(II,II)-Catalyzed Intramolecular Amidation of Carbamates , Chemistry - An Asian Journal . 2007, 2: 1101-1108.

 

Lin X. and Phillips D.L., Density Functional Theory Studies of Negishi Alkyl-Alkyl Cross-Coupling Reactions Catalyzed by a Methylterpyridyl-Ni(I) Complex , The Journal of Organic Chemistry. 2008, 73: 3680-3688.

 

Lin X., Density Functional Theory Studies of Selected Transition Metals Catalyzed C-C and C-N Bond Formation Reactions (PhD Thesis) . 2007.

 

Lin X., Che C.M. and Phillips D.L., Reaction Mechanism and Stereoselectivity of Ruthenium--Porphyrin-Catalyzed Intramolecular Amidation of Sufamate Ester: A DFT Computational Study , Journal of Organic Chemistry. 2008, 73: 529-537.

 

Researcher : Liu B



List of Research Outputs

 

Liu B., Au C.T., Li L. and Cheung A.S.C., Methane Aromatization Over 3 Percent Mo/HZSM-5 Catalyst Investigated by TOF-MS Under Supersonic Jet Expansion Condition , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16-20, . 2008, TJ3.

 

Researcher : Liu CC



List of Research Outputs

 

Liu C.C. and Lin M.C., Screening of TCM as Transcription Inhibitors of MTP Gene, 2nd International Conference on Hypertension, Lipids, Diabetes and Stroke Prevention; Prague, Czech Republic; March 6-8, 2008. . 2008.

 

Shen Z., Yang Z., Gao Y., Li J.C., Chen H.X., Liu C.C., Poon R.T.P., Fan S.T., Luk J.M.C., Sze K.H., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Cancer Research. 2008, 68: 404-414.

 

Researcher : Liu CC



List of Research Outputs

 

Liu C.C. and Lin M.C., Screening of TCM as Transcription Inhibitors of MTP Gene, 2nd International Conference on Hypertension, Lipids, Diabetes and Stroke Prevention; Prague, Czech Republic; March 6-8, 2008. . 2008.

 

Shen Z., Yang Z., Gao Y., Li J.C., Chen H.X., Liu C.C., Poon R.T.P., Fan S.T., Luk J.M.C., Sze K.H., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Cancer Research. 2008, 68: 404-414.

 

Researcher : Liu X



List of Research Outputs

 

Liu X. and Che C.M., A Highly Efficient and Selective AuI-Catalyzed Tandem Synthesis of Diversely Substituted Pyrrolo[1,2-a] Quinolines in Aqueous Media , Angewandte Chemie International Edition. 2008, 47: 3805-3810.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Liu X



List of Research Outputs

 

Liu X. and Che C.M., A Highly Efficient and Selective AuI-Catalyzed Tandem Synthesis of Diversely Substituted Pyrrolo[1,2-a] Quinolines in Aqueous Media , Angewandte Chemie International Edition. 2008, 47: 3805-3810.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Liu Y



List of Research Outputs

 

Liu Y., Zuo J.L., Che C.M. and Li Y.Z., Synthesis and Characterization of a Two-dimensional Manganese Coordination Polymer , 一個錳的二維配位聚合物的合成及其物質, Chinese journal of Inorganic Chemistry . 無機化學學報, 2008, 24: 610-614.

 

Liu Y., Synthesis, Cytotoxicity and Proteomics Studies of Artemisinin Derivatives (PhD Thesis). 2007.

 

Liu Y., Xiao W., Wong M.K. and Che C.M., Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin , Organic Letters. 2007, 9: 4107-4110.

 

Researcher : Liu Y



List of Research Outputs

 

Liu Y., Zuo J.L., Che C.M. and Li Y.Z., Synthesis and Characterization of a Two-dimensional Manganese Coordination Polymer , 一個錳的二維配位聚合物的合成及其物質, Chinese journal of Inorganic Chemistry . 無機化學學報, 2008, 24: 610-614.

 

Liu Y., Synthesis, Cytotoxicity and Proteomics Studies of Artemisinin Derivatives (PhD Thesis). 2007.

 

Liu Y., Xiao W., Wong M.K. and Che C.M., Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin , Organic Letters. 2007, 9: 4107-4110.

 

Researcher : Lo BTK



List of Research Outputs

 

Chung W.K., Lam S.K., Lo B.T.K. and Chiu P., [4+3] Cycloadditions Using Epoxy Enol Silanes as Oxyallyl Cation Precursors , The 18th IUPAC International Conference on Organic Synthesis, Korea, June 22. 2008.

 

Researcher : Lo HS



List of Research Outputs

 

Lo H.S., Yip S.K., Zhu N. and Yam V.W.W., The First Example of a Pt.Pt Interectation in Platinium (II) Complexes Bearing Bulky Tri-tert-Butyl-2,2':6',2"- Terpyridine Pendants via Conformational Control of the Calix[4] Arene Moiety, , Dalton Transactions. 2007, 4386-4389.

 

Researcher : Lo KKW



List of Research Outputs

 

Lo K.K.W., Sze K.S., Tsang K.H.T. and Zhu N., Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteins , Organometallics. 2007, 3440-3447.

 

Lo K.K.W., Tsang K.H.K., Sze K.S., Chung C.K., Lee T.K.M., Zhang K.Y., Hui W.K., Li C.K., Lau J.S.Y., Ng D.C.M. and Zhu N., Non-covalent Binding of Luminescent Transition Metal Polypyridine Complexes to Avidin, Iodole-binding Proteins and Estrogen Receptors , Coordination Chemistry Reviews. 2007, 2292-2310.

 

Researcher : Lo KY



List of Research Outputs

 

Lo K.Y., Wong M.K. and Che C.M., Gold-Catalyzed Highly Enantioselective Synthesis of Axially Chira Alenes , Organic Letters. 2008, 10: 517-519.

 

Lo K.Y., Yip P.K.T. and Yang D., Palladium(II) Catalyzed Oxidative Tandem Cyclizations of Alkenyl Amides, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Lo KY



List of Research Outputs

 

Lo K.Y., Wong M.K. and Che C.M., Gold-Catalyzed Highly Enantioselective Synthesis of Axially Chira Alenes , Organic Letters. 2008, 10: 517-519.

 

Lo K.Y., Yip P.K.T. and Yang D., Palladium(II) Catalyzed Oxidative Tandem Cyclizations of Alkenyl Amides, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Researcher : Lok CN



List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Lok C.N., Ho C.M., Chen R., Tam P.K.H., Chiu J. and Che C.M., Proteomic identification of the Cus system as a major determinant of constitutive escherichia coli silver resistance of chromosomal origin, Journal of Proteome Research. 2008, 7: 2351-2356.

 

Researcher : Low KH



List of Research Outputs

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Researcher : Lu C



List of Research Outputs

 

Lu C., Zu Y. and Yam V.W.W., Nonionic Surfactant-capped Gold Nanoparticles as Postcolumn Reagents for High-performance Liquid Chromatography Assay of Low-molecular-mass Biothiols , Journal of Chromatography A. 2007, 1163: 328-332.

 

Researcher : Lu W



Project Title:

Self-Assembled Nano- and Submicron-Structures from Hybrid Platinum(II) Complexes

Investigator(s):

Lu W, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

The objective of the present project is to develop nano- and submicron-structures and materials from square-planar platinum(II) complexes with cyclometalated and/or terpyridyl ligands. While nano- and submicron-structures based on inorganic metals and semiconductors have been rich in the literature and stepped into large-scale production and found numerous applications in high-tech industries, the nanostructures based on organic and organometallic compounds are in their infancy. The salient advantage of organic or organometallic nano-materials over their more classical inorganic counterparts is that their constituents, the building blocks, are molecular or clusters that can be designed and rationally synthesized, that is, we can produce nano-materials, from organic or organometallic molecular compounds, with predetermined physical properties and these properties can be systematically tuned by harnessing the power of chemical modifications at the molecular level. However, low-dimensional organic nano-materials, usually in their amorphous form (soft matter), has a drawback if we want to apply them in the optoelectronic devices where strictly regular alignment at the nanoscale are requested for facilitate the charge immigration and coupling. One of the solution to this problem is to introduce transition metal ions into the organic molecules, resulting in organometallic compounds. The heavy atoms can help these organic nano-materials to crystallize and facilitate their image process under transmission electron microscope (TEM). In this meaning, organometallic nano-materials are inorganic-organic composites or hybrids at the molecular level. The current project aims to establish a method to introduce metal-metal interactions, here specified as Pt···Pt interactions, into organometallic nano-materials. The role of Pt···Pt interactions is three manifolds here. First, the directionality of the Pt···Pt interactions will facilitate the anisotropic growth of nanocrystals, thus one-dimensional nanostructures, for examples, nanorods, nanowires or nanotubes, are anticipated from these organometallic materials. Second, the backbone based on infinite Pt···Pt metal chain can play as a channel for charge transfer through the one-dimensional nanostructures, thus optoelectronic device with high charge-mobility can be envisaged. Third, the color of the backbone based on infinite Pt···Pt chain is characteristically blue which can be switched to yellow or orange if the weak Pt···Pt interactions are perturbed by some external stimulation, thus sensory nano-materials based on these nanostructures is highly desirable. The current project is a new direction for researches in transition metal complexes, hence the present project is to add further credits to the leading position of HKU in the field of platinum(II) chemistry. Specifically, it is the goal of the project to develop: 1) Synthetic methodology and diverse morphology of nano- and submicron-scale aggregates from square-planar platinum(II) complexes The project aims to explore the synthetic methods, to optimize and pin-down the reaction conditions for the nano- and submicron-scale structures from hybrid square-planar platinum(II) complexes and to identify the electronic and structural factors governing the molecular aggregation. The project aims to develop, from above-mentioned platinum(II) complexes, self-assembled morphology (one-dimensional wire or three dimensional superstructures with possible tube- or sheet-like shapes) in the nanometer or submicron (

 

List of Research Outputs

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Lu W., Chui S.Y., Ng K.M. and Che C.M., A Submicrometer Wire-to-Wheel Metamorphism of Hybrid Tridentate Cyclometalated Platinum(II) Complexes, Angewandte Chemie International Edition. 2008, 47: 4568.

 

Shao F. .W., Elias B., Lu W. and Barton J. .K., Synthesis And Characterization Of Iridium(iii) Cyclometalted Complexes With Oligonucleotides: Insight Into Redox Reaction With Dna, In: Richard Eisenberg, Inorganic Chemistry. Washington DC, USA, ACS, 2007, 46: 10187-10199.

 

Researcher : Ma C



List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Du Y., Xue J., Ma C., Kwok W.M. and Phillips D.L., Time-resolved Resonance Raman and Density Functional Theory Study of the Photochemistry of 4-Benzoylpyridine in Acetonitrile and 2-Propanol , Journal of Raman Spectroscopy . 2008, 39: 503-514.

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Kwok W.M., Ma C. and Phillips D.L., A Doorway State Leads to Photostability or Triplet Photodamage in Thymine DNA , Journal of the American Chemical Society. 2008, 130: 5131-5139.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Researcher : Ma CC



List of Research Outputs

 

Xu Z.P., Zheng Q.S., Jiang Q., Ma C.C., Zhao Y., Chen G. and Gao H., Trans-phonon Effects in Ultra-fast Nanodevices , Nanotechnology. 2008, 19: 255705-1 - 255705-5.

 

Researcher : Ma DL



List of Research Outputs

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Sun R.W.Y., Ma D.L., Wong E.L.M. and Che C.M., Some Uses of Transition Metal Complexes as Anti-cancer and Anti-HIV Agents , Dalton Transactions. 2008, 4884-4892.

 

Researcher : Mak SK



Project Title:

Design and Synthesis of Narrow Band Gap Materials for Photovoltaic Applications

Investigator(s):

Mak SK, Chan WK

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

The objectives of the proposed research are to: i) extend the absorption region of the conjugated polymers by chemical synthetic tailoring the structure of the monomers and different chromophores and ii) increase the extent of interpenetration by either conjugatively linking or tethering the photosensitising dye (including metal complexes) and charge transporting material onto conjugated polymers/oligomers.

 

List of Research Outputs

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Cheng K.W., Mak S.K., Chan W.K., Ng M.C.A. and Djurisic A., Synthesis of conjugated polymers with pendant ruthenium terpyridine trithiocyanato complexes and their applications in heterojunction photovoltaic cells, Journal of Polymer Science: Part A: Polymer Chemistry. Wiley Periodicals, Inc., 2008, 46: 1305-1317.

 

Leung Q.Y., Mak S.K., Tam W.Y. and Chan W.K., Fabrication of Rhenium Containing Narrow Band Gap Polymer for Photovoltaic Applications , Abstract of Europolymer Confernece, 2008, Gargnano (BS-Italy), June 1-5, 2008. Gargnano, Italy, Poster ref. P.30.

 

Mak S.K. and Chan W.K., Electroluminescence from metal containing polymers and metal complexes with functional ligands, In: Hartmut Yersin, Highly efficient OLEDs with phosphorescent materials. Germany, Wiley-VCH, 2007, 329-362.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Wong W.Y., Wang X.Z., He Z., Djurisic A., Yip C.T., Cheung K.Y., Wang H., Mak S.K. and Chan W.K., Metallated conjugated polymers as a new avenue towards high-efficiency polymer solar cells, Nature Materials. Nature Publishing Group, 2007, 6: 521-527.

 

Wong W.Y., Wang X.Z., He Z., Chan K.K., Djurisic A., Cheung K.Y., Yip C.T., Ng M.C.A., Xi Y., Mak S.K. and Chan W.K., Tuning the absorption, charge transport properties, and solar cell efficiency with the number of thienyl rings in platinum-containing poly(aryleneethynylene)s, Journal of the American Chemical Society. American Chemical Society, 2007, 129: 14372-14380.

 

Researcher : Man KKY



List of Research Outputs

 

Pandey A.K., Nunzi J.M., Wang H., Oey C.C., Djurisic A., Xie M.H., Leung Y.H., Man K.K.Y. and Chan W.K., Reverse biased annealing: Effective post treatment tool for polymer/nano-composite solar cells, Organic Electronics. Amsterdam, Elsevier B.V., 2007, 8: 396-400.

 

Xi Y., Li D., Djurisic A., Xie M.H., Man K.K.Y. and Chan W.K., Hydrothermal synthesis vs electrodeposition for high specific capacitance nanostructured NiO films, Electrochemical and Solid-State Letters. The Electrochemical Society, 2008, 11: D56-D59.

 

Researcher : Mo Z



List of Research Outputs

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Researcher : Ng DCM



List of Research Outputs

 

Lo C.S.C., Le Blanc J.C.Y., Yu K.Y., Sze K.H., Ng D.C.M. and Chu I.K., Detection, Characterization, and Quantification or Resveratrol Glycosides in Transgenic Arabidopsis Over-expressing a Sorghum Stibene Synthase Gene by Liquid Chromatography / Tandem Mass Spectrometry , Rapid Communications in Mass Spectrometry . 2007, 21: 4101-4108.

 

Researcher : Ng KM



Project Title:

Development of Chemical Imaging/Profiling Mass Spectrometric (CIMS) Technique for Chemical Analysis and Authentication of Chinese Materia Medica (CMM)

Investigator(s):

Ng KM, Lau ASY, Che CM, Tam PKH

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

Chinese Materia Medica (CMM) has been using for thousand of years to cure and prevent diseases. However, their efficacy has not received international recognition. The fundamental problem is the complex nature of chemicals in herbal medicines. This forms a huge challenge to many research institutions and pharmaceutical companies to produce consistent and efficacious products.Authentication of CMM is one of the most important steps in the quality control of botanical medicines [1,2]. It provides the correct identification of herbal materials, and differentiates different herbal materials with similar morphology. For instance, the roots of Gentiana scabra Bge and Sinopodophyllum hexandrum have very similar morphology. However, Sinopodophyllum hexandrum is toxic and need to have special preparation and instructions from practitioners, while Gentiana scabra Bge is not. Different techniques for the authentication include (i) morphological identification based on shape, color, texture and smell of the herbs [3], (ii) anatomical analysis based on microscopic examination of cell, tissues and internal pattern/structure [4], (iii) DNA-based markers method for identification of different species [1,2] and (iv) chemical pattern analysis based on thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) coupled with different detection systems, like photo-diode array (PDA) and mass spectrometer (MS) [5,6]. All these methods have their own limitations. For instances, morphological identification is highly dependent on the experience of the examiners. DNA-based markers method cannot provide any chemical composition information. The chemical compositions in herbal materials can be greatly affected by the variation of agricultural conditions, geographical locations, harvest time, different parts and species of herbal plants [7-9]. One of the major reasons is due to the variation of enzymatic activities being responsible for the formation/conversion of primary/secondary metabolites under different growing conditions [7-9]. The presence, absence and different distribution of phytochemicals in herbal plants can potentially form a unique characteristic for differentiating different species, parts and growing conditions of herbal plants. However, chemical analysis of CMM in a bulk form of extract by using TLC, or HPLC/PDA/MS method will loss the unique chemical distribution profile in the herbal materials. Moreover, the methods usually require sample treatment under different extraction conditions, such as high temperature conditions. This may destroy/change the chemical compounds, and thus being unable to measure the original chemical compositions. Development of a chemical imaging analytical method for measuring the spatial distribution of chemicals/phytochemicals in herbal tissues will be a breakthrough in the chemical analysis of CMM. The methodology can construct chemical imaging/profiling for herbal plant, which is specific for different parts and species of herbal plants grown under different agricultural conditions. It is a potential methodology for the authentication of CMM. The schematic diagram showing the working principle of measuring a chemical imaging/profiling of CMM is depicted in Figure 1 (as shown in Research Plan and Methodology). In the process, a laser beam hit on the cross-section of a plant tissue will cause phytochemicals desorbed from different positions. The desorbed ions are then pushed from an electrical conductive slide, on which the plant tissue is placed. The desorbed chemical ions in the gas phase will be detected by a mass spectrometer. Those ion peaks recorded in mass spectra represent the chemicals at different positions of the cross-section. The ion peaks in the mass spectra can then be reconstructed by using an imaging software to generate a chemical image, which can show the spatial distribution of phytochemicals in the plant tissue. In fact, chemical imaging/profiling mass spectrometry using matrix-assisted laser desorption ionization (MALDI) method has been being developed as a valuable and important analytical tool in many areas of biomedical science [10,11]. This technique was firstly introduced in 1999 [12] for the analysis of peptides/proteins desorbed directly from intact biological tissues without any sample treatment. With the advancement of the technique, it is further extended to analyze the spatial distribution of drugs and their metabolites in different biological tissues, like rat liver and human ovarian tumor xenograft tissue [13]. However, the application of this technology in measuring the chemical profile distribution of phytochemicals/secondary metabolites in plant tissue has not been explored yet. In this project, our ultimate objective is to develop a molecularly and spatially resolved chemical imaging methodology for measuring the distribution of phytochemicals in the cross-section of herbal tissue. Specifically, we are trying to develop a methodology for differentiating different species of herbal plants grown under different agricultural conditions based on the presence, absence and different distribution of chemicals in herbal tissues. Panax ginseng C.A. Mey (Asian Ginseng) and Panax quinquefolium L. (American Ginseng) with huge markets in both eastern countries and western countries will be taken as the examples for the method development. 1. Liang Y.Z., Xie P. and Chan K. "Quality Control of Herbal Medicines", Journal of Chromatography B, 812, 53 - 70 (2004)2. Shaw P.C., Wang J. and But P.P.H. "Authentication of Chinese Medicinal Materials by DNA Technology", The Chinese University of Hong Kong, World Scientific, Singapore (2002)3. Zhao Z.Z. An Illustrated Chinese Materia Medica In Hong Kong, Chung Hwa Book Co., (H.K.) LTD. (Chinese and English Version) (2004)4. Zhao Z.Z. An Illustrated Microscopic Identification of Chinese Materia Medica. Chung Hwa Book Co., (H.K.) LTD.(Chinese and English Version) (2005)5. Niessen W.M.A., "Liquid Chromatography Mass Spectrometry", Second Edition, Dekker, New York (1999)6. Bringmann G., Messer K., Wohlarth M., Kraus J., Dumbuya K. and Ruckert M. "HPLC-CD On-Line Coupling in Combination with HPLC-NMR and HPLC-MS/MS for the Determination of the Full Absolute Stereostructure of New Metabolites in Plant Extracts", Analytical Chemistry, 71, 2678 - 2686 (1999)7. Vickery M. L. and Vickery B. "Secondary Plant Metabolism" Macmillan Press, London (1981)8. Smirnoff N. "Environment and Plant Metabolism - flexibility and acclimation", Bios Scientific, UK (1995)9. Emes M. J. "Compartmentation of Plant Metabolism in Non-Photosynthetic Tissues", Cambridge University Press, Cambridge (1991)10. Caldwell R.L. and Caprioli R.M. "Tissue Profiling by Mass Spectrometry", Molecular and Cellular Proteomics, 4.4, 394 - 401 (2005)11. Rohner T.C., Staab D. and Stoeckli M. "MALDI Mass Spectrometric Imaging of Biological Tissue Sections", Mechanisms of Ageing and Development, 126, 177 - 185 (2005) 12. Chaurand P., Stoeckli M. and Caprioli R.M. "Direct Profiling of Proteins in Biological Tissue Sections by MALDI Mass Spectrometry" Analytical Chemistry, 71, 5263 - 5270 (1999)13. Troendle F., Reddick C.D. and Yost R.A. "Detection of Pharmaceutical Compounds in Tissue by Matrix-Assisted Laser Desorption / Ionization and Laser Desorption / Chemical Ionization Tandem Mass Spectrometry with a Quadrupole Ion Trap", Journal of American Society for Mass Spectrometry, 10, 1315 - 1321 (1999)14. Schwartz S.A., Reyzer M.L. and Caprioli R.M. "Direct Tissue Analysis Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry: Practical Aspects of Sample Preparation", Journal of Mass Spectrometry, 38, 699 - 708 (2003)

 

List of Research Outputs

 

Feng Y., Tsao G.S.W., Tong Y. and Ng K.M., Matching Grant (4th Phase)-Research project on alternative drug for bear bile, UGC (Government Matching Grant Scheme). 2008, HK$402,500.

 

Feng Y., Tsao G.S.W., Tong Y. and Ng K.M., Research project on alternative drug for bear bile, Yiqingzhai Foundation (The Pong Ding Yueng Endowment Fund for Education & Research in Chinese-Western Medicine). 2008, HK$805,000.

 

Lu W., Chui S.Y., Ng K.M. and Che C.M., A Submicrometer Wire-to-Wheel Metamorphism of Hybrid Tridentate Cyclometalated Platinum(II) Complexes, Angewandte Chemie International Edition. 2008, 47: 4568.

 

Rong J., Tilton R., Shen J., Ng K.M., Liu C., Tam P.K.H., Lau A.S.Y. and Cheng Y.C., Genome-wide Biological Response Fingerprinting (BioReF) of the Chinese Botanical Formulatrion ISF-1 Enables the Selection of Multiple Marker Genes as a Potential Metric for Quality Control , Journal of Ethno-Pharmacology . 2007, 113: 35-44.

 

Tang H.W., Ng K.M., Liang Z.T., Che C.M., Cheng Y.C. and Zhao Z.Z., Histochemical Analysis of Medicinal Plants by Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry, 6th Meeting of Consortium for Globalization of Chinese Medicine, Beijing, China. 2007.

 

Tang H.W., Ng K.M. and Che C.M., Internal Energy Transfer in Carbon-based Surface-Assisted Laser Desorption/Ionization: Graphite versus Diamond, The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Colorado Convention Center, Denver, Colorado, U.S.A.. 2008, ThP085.

 

Researcher : Ng SM



Project Title:

Molecular cloning and functional characterization of the human cell cycle related kinase-interacting proteins

Investigator(s):

Ng SM, Lin MC

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

1. To clone the genes encoding the proteins that specifically interact with CCRK in a yeast two-hybrid screening. 2. To elucidate the functional roles of the CCRK-interacting proteins in glioblastoma carcinogenesis.

 

List of Research Outputs

 

Li H.Y., Chau D.H.W., Gao Y., Ng S.M. and Lin M.C., Genome-wide Expression Profiling Reveals the Multiple Signaling Pathways Modulated by rAdv-hTERTC27 Treatment in Glioblastoma Multiforme, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong.. 2007.

 

Ng S.M., Yang P., Cheng Y., Peng Y., Kung H.F. and Lin M.C., Differential and Critical Roles of Reactive Oxygen Species and Reactive Nitrogen Species in Alcohol-Induced Gene Dysregulations and Birth Defects in Xenopus Embryos, Neuroembryology and Aging. 2007, 4: 155-161.

 

Researcher : Nie Z



List of Research Outputs

 

Nie Z. and Fung Y.S., Microchip Capillary Electrophoresis for Frontal Analysis of Free Bilirubin and Study of its Interaction with Human Serum Albumin , Electrophoresis. 2008, 29: 1924-1931.

 

Nie Z. and Fung Y.S., Mircofluidic Chip-Capillary Electrophoresis for Quality Assessment of a Complex Herbal Preparation , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:48, pp 5:141.

 

Nie Z. and Fung Y.S., Multi-segment Incremental Sample Injection for the Determination of Bilirubin Binding Capacity of Albumin and Study of Drug Interaction by Microchip Capillary Electrophoresis , 22nd International Symposium of Microscale Bioseparations & Methods for System Biology (MSB 2008), Berlin, Germany, March 9-13, 2008. Paper P.284-Tu, pp417.

 

Researcher : Pan J



List of Research Outputs

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Researcher : Pang HF



List of Research Outputs

 

Pang H.F., Ye J., Leung W.H., Chen G. and Cheung A.S.C., Experimental and Theoretical Studies of Diatomic Iridium Compounds , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16,. 2008, MF12.

 

Ye J., Pang H.F., Wong M.Y., Leung W.H. and Cheung A.S.C., Laser Spectroscopy of Iridium Monoboride , The Journal of Chemical Phyics. 2008, 128: 154321-1 - 154321-6.

 

Researcher : Peng T



List of Research Outputs

 

Peng T. and Yang D., Development of Fluorescent Probes for Detection of Peroxynitrite , The 234th American Chemical Society National Meeting, Boston, U.S.A., August 19-23, 2007.

 

Researcher : Phillips DL



Project Title:

Time-Resolved Resonance Raman and Density Functional Theory investigation of the structure, properties and chemical reactivity of selected weakly bound species containing S and/or halogen atoms

Investigator(s):

Phillips DL

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

The proposed study will provide important characterization and insight into the structures, properties and chemical reactivity of selected radical cations, radical anions and neutral species containing weak bonds formed from a singly occupied sulfur or halogen p orbital and lone pairs of S or halogen atoms. This fundamental work will lead to an improved understanding of the likely role of these species in the biological activity of many proteins, enzymes and antibiotics as well as in protection mechanisms for biological systems attacked by ionizing radiation or other kinds of free-radical damage. The propossed work for halogen containing systems should help elucidate the likely role of these types of species in environmental and atmospheric chemistry. Comparison of the 2c-3e bonding in the radical cation and anion complexes to those of the isopolyhalomethane and halogenated solvent-halogen atom complexes that are neutral species should enable an improved understanding of how the structure, properties and chemical reactivity vary with oxidation state for these loosely bound complexes.

 

Project Title:

Investigation of Water Assisted Dehalogenation Reactions of Polyhalomethanes and Other Selected Halogenated Compounds

Investigator(s):

Phillips DL

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2004

 

Abstract:

To study: (1) observe and characterize the structure, properties and chemical reactivity of the reaction intermediates involved in the dehalogenation reactions of polyhalomethanes and other selected halogenated compounds in water solution using picosecond and nanosecond time-resolved resonance Raman spectroscopy. (2) the final products from these photochemical dehalogenation reactions will be determined using a variety of spectroscopic and analytical techniques like UV/VIS, 1H-NMR, 13C-NMR, infrared absorption, pH measurements in combination with laser photochemistry experiments. (3) Ab initio chemical reaction calculations will be used to elucidate the reaction pathways and probable role of water solvent molecules in the dehalogenation reactions of polyhalomethanes and other selected halgoenated compounds to be studied and compared to the experimental results of parts 1 and 2. This will help to elucidate the reaction mechanism(s) of the dehalogenation reactions.

 

Project Title:

Development of novel formulations for coatings and paints employing nanotechnology

Investigator(s):

Phillips DL, Chan WK

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

10/2004

 

Abstract:

To collaborate with Manfield Coatings Co. Ltd., develop new coating and paint products especially those that employ nanotechnology additives that will meet the specifications of their customers who needs it for manufacturing new advanced electronic products.

 

Project Title:

Time-resolved resonance raman spectroscopic investigation of selected reactions of arylnitrenium ions with guanine derivatives

Investigator(s):

Phillips DL

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2006

 

Abstract:

(1) Carcinogenic aromatic amines are found in automobile exhaust, tobacco smoke, broiled meat and trace produces from some industrial processes. When metabolized, these types of aromatic amines cause damage to guanine bases in DNA and increase the probability for tumors or cancers. Arylnitrenium ions are the key intermediates in the metabolism of aromatic amines that selectively react with guanine in DNA. It is important to characterize these arylnitrenium ions and their reactions with guanine derivatives in as much detail as possible. There is not much vibrational spectropscopic level structural informationavailable for many arylnitrenium ions and their reactions. The broad objective of this proposal is to use time-resolved resonance Raman spectroscopy to obtain this missing structural information for selected arylnitrenium ions and thier reactions with guanine derivatives. The more specific objectives and issues are detailed in objectives 2-6.(2) Reactions of several para-phenyl subtituted phenylnitrenium ions like 2-fluorenylnitrenium and 4-biphenylnitrenium ions predominantly form C8 adduct species after reaction with guanaine derivatives. Metabolism of 2-aminofluorene and 4-aminobiphenyl also form these same C8-adducts after in vivo and in vitro reaction with DNA. The reaction mechanism for how these C8 adducts are formed is not clear and three different mechanisms have been proposed. We propose to use time-resolved resonance Raman spectroscopy to directly observe the formation of the reaction of the arylnitrenium ions with different guanine derivatives in order to better understand the reaction mechanism for formation of the C8 adducts. This work should elucidate what mechanism(s) are responsible for C8 adduct formation.(3) The degree of quinoidal character of some arylnitrenium ions has been found to vary significantly and it is not clear how this influences their chemical reactivity towards guanine derivatives. It is now known that the 4-biphenylnitrenium ion has noticeably less quinoidal character than the 2-fluorenylnitrenium ion. We propose to use time-resolved resonance Raman spectroscopy to for both the 2-fluorenylnitrenium and 4-biphenylnitrenium ions reactions with guanine derivatives to form intermediate species. This work should elucidate how the degree of quinoidal character affects the chemical reactivity of these arylnitrenium ions. (4) In vitro reaction of the carcinogen, N-hydroxy-2-aminonaphthalene with DNA forms adducts attached to the C8 and N2 positions of guanine while the reaction of N-hydroxy-1-aminonathylene with DNA in vivo and in vitro forms adducts attached to the O6 position of guanine. The reason for this substantial difference in the adducts formed from the reaction with DNA of these two closely related carcinogenic aminonapthalene derivatives is not known. We propose to use time-resolved resonance Raman spectroscopy to directly examine the structure and properties of the highly reactive 1-naphthylnitenium and 2-naphthylnitrenium ions and their reactions with selected guanine derivatives. This research will provide an improved understanding of the structure and chemical reactivity of naphthylnitrenium ions. (5) Nitroimidazoles are a kind of antibiotics that are effective against anaerobic bacterial and protozoal infections. The imidazolylnitrenium ion intermediates are thought to play an important role in the reductive metabolism of nitroimidazoles. We propose to use time-resolved resonance Raman spectroscopy to directly investigate the structure, properties and chemical reactivity of this interesting class of imidazolylnitrenium ions. Experiments will be done for the 1-methyl-2-imidazolylnitrenium ion and its reactions with GSH, phosphate and some guanine derivatives. This proposed research will help explain why imidazolylnitrenium ions are very selective towards GSH. This work may also help elucidate why nitroimidazoles are effective antibiotics while some para-phenyl substituted phenylnitrenium ions and naphthylnitrenium ions appear to be associated with the metabolism of potent carcinogens. (6) The proposed research associated with the objectives 1-5 above is for arylnitrenium ions and their reactions with mainly free nucleosides and substrate molecules. At present it is not understood how similar or different the chemical reactivity of arylnitrenium ion reactions with free nucleosides are from the corresponding reactions with larger systems like oligomers of guanine or genomic DNA. We would like to begin preliminary research to start to examine this issue. We propose to use time-resolved resonance Raman spectroscopy to study the reactions of the 2-fluorenylnitrenium ion with some oligomers containing guanine and perhaps calf thymus DNA. These results will be directly compared to those obtained for reactions with the free nucleosides and their reaction products so as to explore the influence of the oligomer or DNA environments on these arylnitrenium ion reactions.

 

Project Title:

Time Resolved Spectroscopy and Density Functional Theory Studies of Selected Ultrafast Phototrigger Compounds

Investigator(s):

Phillips DL, Ma C

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2007

 

Abstract:

Compounds based on benzoin and coumarin chromophores are being developed for new generations of innovative and improved phototriggers being developed for a range of applications in physiology, medicine and cell biology as well as photochemical synthesis.[1-20] So as to best design and develop these new classes of phototrigger compounds for particular applications, it is very important to better understand how they occur and what kinds of intermediates are involved in these novel photodeprotection reactions. Currently, the properties and identities of the reaction intermediates and the reaction mechanisms for deprotection (or release of the desired leaving group) and the formation of the side products are not well known or characterized for many of the compounds of interest. [1-20] The project we propose to develop for a RGC grant application will use several kinds of time-resolved spectroscopy techniques to obtain this missing information and to elucidate the reaction mechanisms for the deprotection reactions and formation of side product reactions. Kerr-gated time-resolved fluorescence (KTRF) , time-resolved transient absorption (TA) and time-resolved resonance Raman (TR3) spectroscopies will be employed to directly examine and characterize the reaction intermediates and reaction mechanisms of the deprotection reactions and formation reactions of the side products for the phototrigger compounds of interest. The proposed project experiments will help to clearly identify the reaction intermediates involved in the deprotection from the nascent photophysics to the final products for the benzoin and coumarin based phototrigger compounds selected for investigation. This new information and improved understanding of the reaction intermediates and mechanisms should prove helpful to direct further developments of these and related classes of phototrigger compounds. This seed proposal will be used to investigate the feasibility of synthesizing suitable amounts of precursor compounds for the proposed time resolved spectroscopy experiments and to do preliminary time-resolved spectroscopy experiments of selected benzoin and coumarin based phototrigger compounds to demonstrate the utility of the proposed time-resolved spectroscopy techniques to study the reaction intermediates and mechanisms. This work will enable us to show the feasibility of our proposed RGC project and to strengthen the proposal to be submitted to RGC. First, we will try to synthesize and purify gram quantities of a couple of meta methoxy substituted benzoin phototrigger compounds for use as a precursor in some time resolved spectroscopy experiments.[2,17] Second we will try some preliminary time-resolved spectroscopy experiments (like KTRF, TA and TR3) to see if we can observe the reaction intermediates and acquire good quality spectra of these intermediates. We will also perform a preliminary interpretation of the data and write up the preliminary results and submit them for publication in a top refereed international journal. Similarly, we will attempt to synthesize and purify gram quantities of a couple of selected coumarin based phototrigger compounds [13,14] that can be utilized as a precursor in time-resolved experiments (such as KTRF, TA and TR3) to determine if we will be able to observe the reaction intermediates and obtain good spectra of them. An initial interpretation of the time-resolved data will be done and these results will also be submitted for publication in a top refereed journal. The details of the proposed preliminary work to achieve the objectives and address the problems being addressed in this project will be presented in the research plan and methodology section. For references, please see reference section attached to this proposal.

 

List of Research Outputs

 

Chen X., Ma C., Kwok W.M., Guan X., Du Y. and Phillips D.L., A Theoretical Investigation of P-Hydroxyphenacyl Caged Phototrigger Compounds: How Water Induces the Photodeprotection and Subsequent Rearrangement Reactions , Journal of Physical Chemistry B. 2007, 111: 11832-11842.

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Du Y., Xue J., Ma C., Kwok W.M. and Phillips D.L., Time-resolved Resonance Raman and Density Functional Theory Study of the Photochemistry of 4-Benzoylpyridine in Acetonitrile and 2-Propanol , Journal of Raman Spectroscopy . 2008, 39: 503-514.

 

Guo Z., Lin X., Zhao C. and Phillips D.L., Density Functional Theory Study of Water-assisted Deprotonation of the C8 Intermediate in the Reaction of the 2-Fluorenylnitrenium Ion with Guanosine to form a C8 Adduct, Journal of Molecular Structure: THEOCHEM. 2008, 848: 119-127.

 

Guo Z., Ke Z.F., Phillips D.L. and Zhao C.Y., Intrinsic Reaction Coordinate Analysis of the Activation of CH4 by Molybdenum Atoms: A Density Functional Theory Study of the Crossing Seams of the Potential Energy Surfaces , Organometallics. 2008, 27: 181-188.

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Jiang X.L., Pei K.M., Wang H.G., Zheng X.M., Fang W.H. and Phillips D.L., Resonance Raman Intensity Analysis of the Excited-State Proton-Transfer Dynamics of 2-Hydroxybenzaldehyde in the Charge-Transfer / Proton-Transfer Absorption Band , Journal of Physical Chemistry A. 2007, 111: 13182-13192.

 

Kwok W.M., Ma C. and Phillips D.L., A Doorway State Leads to Photostability or Triplet Photodamage in Thymine DNA , Journal of the American Chemical Society. 2008, 130: 5131-5139.

 

Kwok W.M., Chu L.M., Guan X., Tang W.J., Ma C. and Phillips D.L., Observation of Ultrafast Cycloreversion after Photoexcitation of an Oxetane , Poster Presentation and Abstract of ICP2007 - XXIII International Confernce on Photochemistry, Cologen, Germany, July 29 - August 3, 2007 . 2007.

 

Lin X., Zhao C., Che C.M., Ke Z.F. and Phillips D.L., A DFT Study on the Mechanism of Rh2(II,II)-Catalyzed Intramolecular Amidation of Carbamates , Chemistry - An Asian Journal . 2007, 2: 1101-1108.

 

Lin X. and Phillips D.L., Density Functional Theory Studies of Negishi Alkyl-Alkyl Cross-Coupling Reactions Catalyzed by a Methylterpyridyl-Ni(I) Complex , The Journal of Organic Chemistry. 2008, 73: 3680-3688.

 

Lin X., Che C.M. and Phillips D.L., Reaction Mechanism and Stereoselectivity of Ruthenium--Porphyrin-Catalyzed Intramolecular Amidation of Sufamate Ester: A DFT Computational Study , Journal of Organic Chemistry. 2008, 73: 529-537.

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Ng M.C.A., Djurisic A., Tam K.H., Kwok W.M., Chan W.K., Tam W.Y., Phillips D.L. and Cheah K.W., Organic nanoclusters on inorganic nanostructures for tailoring the emission properties of organic materials, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 566-574.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.

 

Phillips D.L., Time-Resolved Spectroscopic Studies of Selected Phototrigger Compounds and Arylnitrenium Ions , Invited lecture at Zhejiang University, Hangzhou, P.R. China, November 28, 2007 . 2007.

 

Phillips D.L., Time-Resolved Spectroscopic Studies of the Photophysics and Photochemistry of Phototrigger Compounds and the Properties and Chemistry of Arylnitrenium Ions , Invited Lecture at Nanjing University, Nanjing, P.R. China, September 20, 2007 . 2007.

 

Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Asian Conference on Ultrafast Phenomena at the National University of Singapore, Singapore, January 6-9, 2008 . 2008.

 

Xue J., Du Y., Chuang Y.P., Phillips D.L., Wang J., Luk C., Hadad C.M. and Platz M.S., Time-Resolved Resonanc Raman Observation of the Dimerization of Didehydroazepines in Solution , Journal of Physical Chemistry A. 2008, 112: 1502-1510.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Ren J



List of Research Outputs

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Chan G.K.Y., Ren J., Wang H. and Ding J., Strategies of Nanostructing Fuel Cell Electrodes , Proceedings of 2007 First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007.

 

Ren J., Preparation and Characterization of Mesoporous Carbons for Energy Application (PhD Thesis). 2007.

 

Researcher : Sham IHT



Project Title:

Magnitized dendrimers and hyperbranched polymers for controlled delivery of targeted drugs

Investigator(s):

Sham IHT, Che CM, Kung H

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To achieve controlled delivery of drugs to target sites using magnetized dendrimers and hyperbranched polymers as vehicles.

 

List of Research Outputs

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., 234th ACS National Meeting. 2007, Poly-319.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., Polymer Preprints (American Chemical Society, Divison of Polymer Chemistry). 2007, 48: 589 - 590.

 

Li C., Kui C.F., Sham I.H.T., Chui S.Y. and Che C.M., Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4-Nitrophenylthiolate Ligand: Observation of p->p*Charge-Transfer Emission , , European Journal of Inorganic Chemistry. Wiley-VCH, 2008, 2421-2428.

 

Researcher : Shen Z



List of Research Outputs

 

Leung W.S., Shen Z., Yiu S.M., Kung H.F. and Lin M.C., Characterization of HGFK1 Signaling Networks in Microvessel Endothelial and Hepatoma Cell Lines, International Conference on Bioinformatics 2007; 27-30 August 2007; Hong Kong. 2007.

 

Shen Z., Yang Z., Gao Y., Li J.C., Chen H.X., Liu C.C., Poon R.T.P., Fan S.T., Luk J.M.C., Sze K.H., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Cancer Research. 2008, 68: 404-414.

 

Shen Z., Leung W.S., Yiu S.M., Kung H.F. and Lin M.C., The Molecular Mechanisms of the Dual Anti-angiogenic and Anti-tumor Effects of rAAV-HGFK1, 11th Annual Meeting of the American Society of Gene Therapy May 28-June 1, 2008; Boston, Massachusetts, USA.. 2008.

 

Researcher : Siu AFM



Project Title:

Characterisation of neurotransmitters

Investigator(s):

Siu AFM, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study neurotransmitter on the following two aspects: (1) characterisation of the molecular interactions between neurotransmitters (dopamine, norepinephrine, epinephrine etc) and ions (Na+, etc); (2) characterisation of the conformational change of neurotransmitters at the model protein receptor binding sites.

 

List of Research Outputs

 

Chan P.H., So P.K., Ma D.L., Zhao Y.X., Lai T.S., Chung W.H., Chan K.C., Yiu K.F., Chan H.W., Siu A.F.M., Tsang Y.C., Leung Y.C., Wong K.Y. and Wong K.Y., Fluorophore-Labeled: b-Lactamase as a Biosensor for b-Lactam Antibiolics: A Study of the Bosensing Process, Journal of the American Chemical Society. 2008, 46: 740-749.

 

Researcher : Siu SO



List of Research Outputs

 

Chu I.K., Zhao J., Xu M., Siu S.O., Hopkinson A.C. and Siu K.W.M., Are the Radical Centers in Peptide Radical Cations Mobile? The Generation, Tautomerism, and Dissociation of Isomeric a-Carbon-Centered Triglycine Radical Cations in the Gas Phase, Journal of the American Chemical Society. 2008, 130: 7862-7872.

 

Researcher : Song K



List of Research Outputs

 

Chen F., Song K., Wu Y.D. and Yang D., Synthesis and Conformational Studies of g-Aminoxy Peptides , Journal of the American Chemical Society. 2008, 130: 743-755.

 

Researcher : Sun H



Project Title:

Characterization of a nickel-storage protein Hpn: its relation with bismuth antiulcer drugs

Investigator(s):

Sun H, Huang J

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To evaluate the nickel binding properties of the protein. Hpn will be overexpressed in E. coli using recombinant DNA technology; to evaluate the effects that nickel (and zinc) have upon Hpn secondary structure and stability; to get preliminary data on the three-dimensional structure of the protein. The protein structure will be investigated by NMR spectroscopy and other spectroscopic techniques.; to investigate the competitive binding of bismuth and Ni2 to Hpn and the structural differences between the Ni2+ and Bi3+ loaded forms.

 

Project Title:

Functional and structural characterization of lipoprotein MtsA in MtsABC responsible for transport of iron and other metal ions in Streptococcus pyogenes

Investigator(s):

Sun H, He Q

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2005

 

Abstract:

To comprehensively investigate the metal binding properties of MtsA; to study the function-structure relationship of MtsA.

 

Project Title:

Metal-based Drug Design: Bismuth Complex as an Antiviral Agent

Investigator(s):

Sun H, Zheng B

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2005

 

Abstract:

(1) To design and synthesize novel bismuth containing complexes for antiviral tests. Our preliminary data showed that both ranitidine bismuth and Bi(NTA) can effectively inhibit SARS-CoV helicase (IC50 < 1 μM), indicating that the Bi3+ plays the crucial role in the inhibitory effects. (2) To characterize their structures and stabilities under biological conditions. In order to determine the potential structure-activity relationship of these complexes, their structures will be investigated by various chemical and biochemical techniques (e.g., X-ray crystallography and NMR spectroscopy). (3) To test antiviral activities of these complexes in different systems. An efficiency cell culture system for SARS, HIV and hepatitis B virus (HBV) has been established in the Co-I’s laboratory.

 

Project Title:

Identification of Metal-binding Proteins in Microorganisms by Metalloproteome

Investigator(s):

Sun H

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2006

 

Abstract:

There is an increasing interest in the analysis of proteins carrying out all functional work in cells in the post-genome era [1,2]. The term “proteomics” refers to the global analysis of the gene and cellular function at the protein level in a complex biological system at a given time. Proteomics has mainly been used to determine protein express levels, post-translational modification, localizations and protein-protein interactions as well as protein structures, the so-called “structural genomics” using biological mass spectrometry and X-ray crystallography/NMR spectroscopy with the aid of various data base. “Metalloproteome” is a special proteomics strategy for the analysis of metal transporting or metal-binding proteins, and has the potential to uncover how a large number of metallo-proteins function in normal or metal-associated diseased /metallodrug treated states [3,4]. Immobilized-metal-affinity chromatography (IMAC) has been widely used to pre-fractionalize proteins previously and recently to selectively identify/enrich metal-“associated” proteins. Metal ions such as iron, copper and zinc are essential for lives; metal-related diseases have been well known. The use of Cu- and other IMAC technology and mass spectrometry allows copper and zinc “metallproteome” to be analyzed in several cell lines [5]. The success of cisplatin [cis-diamminedichloroplatinum(II)] as an anticancer drug has stimulated the use of metal-containing compounds for therapy and medical diagnosis [6,7]. Both bismuth (e.g. colloidal bismuth subcitrate (CBS) and ranitidine bismuth citrate (RBC)) and antimony (e.g. stibogluconate) have also been widely used for the treatment of gastrointestinal distress such as peptic ulcer and H. pylori infection and parasitic infection (Sb for Leishmania) for decades [8]. Proteins and enzymes have long been regarded as the targets of the metallodrugs although little is known about the detail targets. Using our initial work as a foundation, we will design and prepare immobilized metal affinity chromatography (IMAC) in combination with mass spectrometry to identify metal-binding proteins in microorganisms (e.g. Helicobacter pylori). This study will not only allow us to discover novel metal-binding proteins or metallodrug target(s), but also offer a general approach for the investigation of metabolism of metallodrugs, which eventually improve our understanding of mechanism of action of the metal-containing agents. We intend to achieve three separate but closely related objectives: (A) To design and prepare a series of metal-containing IMAC column (e.g., Bi3+, Sb5+, Cd2+ and Fe3+) for metalloproteome; (B) To identify metal-binding proteins and peptides by IMAC and mass spectrometry; (C) To discover metal-binding motifs/sites. (D) To further confirm these proteins by overexpression of selected proteins and examine their binding properties

 

Project Title:

The role of metal ions on protein structural and conformational changes and folding - potential relevance to diseases

Investigator(s):

Sun H

Department:

Chemistry

Source(s) of Funding:

Matching Fund for NSFC Young Researcher Award

Start Date:

02/2006

 

Abstract:

To investigate the role of metal ions on protein structural and conformational changes and folding - potential relevance to diseases.

 

Project Title:

Biocoordination chemistry of bismuth and antimony: a metalloproteomic study

Investigator(s):

Sun H, He Q

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

1. To investigate the transient effect of metallodrugs on microorganisms (e.g. Helicobacter pylori and Leishmaniasis) by comparative proteomics using 2D-polyacrylamide gel electrophoresis (2-DE). 2. To identify the metal-binding proteins and peptides by the combination of IMAC and biological mass spectrometry. 3. To determine the metal-binding motifs by IMAC and other biophysical techniques. 4. To summarize the biocoordination chemistry of antimony and bismuth in microorganisms and study the mechanism of action of metallodrugs.

 

Project Title:

Copper Transport Protein, hCtr1 and its Role for Cellular Uptake of Platinum Anticancer Drugs

Investigator(s):

Sun H

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

Copper is an essential element for all living cells, serving as cofactors for numerous proteins with diverse functions including electron transfer, dioxygen binding (O2) and catalysis (e.g. Cu, Zn-SOD) [1,2]. It has two oxidation states in biological system, i.e. mono- and di-valent (Cu+, Cu2+). Similar to other essential metals, it is also toxic at the elevated concentration and various diseases have been found to directly or indirectly relate to copper. Therefore uptake and trafficking must be strictly regulated. Copper homeostasis is companied by the action of copper transporter (hCtr1) and copper chaperones. The high affinity copper (Cu(I)) uptake at the plasma membrane in humans is mediated by the hCtr1 protein, a three-putative transmembrane protein (Fig. 1) [3-5]. Recent study showed that the protein is a compact trimer with a novel channel-like architecture [6]. Unexpectedly, the widely used anticancer drug, cisplatin [cis-diammedichloroplatinum(II)], was recently found to be transported by this protein both in yeast and mammalian [7,8]. Deletion of yCtr1 in yeast or mCtr1 in mouse embryonic fibroblasts leads to the anticancer resistance due to the reduced uptake of the drug [8]. Mutagenesis experiments have demonstrated that the methionine- and histidine-rich region in the N-terminus of hCtr1 was required and stabilized the formation of a multimer of the protein induced by cisplatin [9]. The objective of this project is to establish a platform for the study of metallodrugs and metalloproteins. In the next 12 months, I will focus on four parts to build a strong foundation for further development and the results will be used as initial data for seeking external funding: Firstly, the Met- and His-rich domain in the N-terminus of hCtr1 will be expressed by recombinant DNA technology (due to limited budget and difficulty for the expression of the transmembrane part) and the experimental condition will be optimized in order to get high yield. Our extensive experience on metalloprotein expression (e.g. human metallothionein-III and histidine-rich protein Hpn) demonstrates that we can do this readily [10,11]. Secondly, the stability of the protein under a variety of conditions will be examined and its potential ability to bind to Cu(I) and cisplatin will be investigated. The metal binding site(s)/residues will be initially identified based on the changes of chemical shifts or coupling between the metal (e.g. Pt(II) and Ag(I) (NMR nucleus-active substitute for Cu(I)) and the binding residues (e.g. 1J(Pt, N) and 2J(Pt, C)). We have previously characterized the cysteine-rich protein, metallothionein, the histidine-rich protein Hpn and the iron transport protein, transferrin and DMT1 by NMR and other biophysical techniques [10-15]. Thirdly, kinetics of metal binding and storage will be illustrated. The potential effect of the protein on the hydrolysis of cisplatin and related platinum anticancer drugs will also be followed by the 15N-labeled cisplatin (cis-[Pt(NH3)2Cl2]. The installation of a CyroProbe in the PI's laboratory will allow the study at lower concentration of cisplatin and the protein, which is more physiologically relevant. The PI has extensive experience in chemistry/biochemistry of metallodrugs and expects to complete this objective successfully. Finally, the migration of the platinum anticancer drugs, e.g. cisplatin from its hCtr1-bound to other nitrogen-containing bio-molecules such as 5'-GMP, dGpG and DNA fragments will be investigated by 2D [1H, 15N] HSQC NMR with the aid of 15N-labeled cisplatin and doubly labeled protein. The PI has extensive experience on antimony- and bismuth-containing drugs and their interactions with proteins and nucleic acids, and it is a natural extension of his previous work and shall provide important information on the cellular uptake of the anticancer drug. The relevant experimental procedures and techniques have been established in the PI's laboratory, including protein expression and characterization, structural determination and models for kinetic analysis. Under this internal research program, enough initial results will be obtained which will significantly help to apply for external support (e.g. CERG or NSFC/RGC). It is reasonable to expect that the project will be completed in 12 months.

 

List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Ding Z.C., Zheng Q., Cai B., Yu W.H., Teng X.C., Wang Y., Zhou G.M., Wu H.M., Sun H., Zhang M.J. and Huang Z.X., Effect of a-domain Substitution on the Structure, Propety and Function of Human Neuronal Growth Inhibitory Factor , Journal of Biological Inorganic Chemistry. 2007, 1173-1179.

 

He J., Hu P., Wang Y.J., Tong M.L., Sun H., Mao Z.W. and Ji L.N., Double-strand DNA cleavage by copper complexws of 2,2'-dipyridyl with guanidinium / ammonium pendants , Dalton Transactions. 2008, 3207-3214.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Li H., Gu J.D. and Sun H., Structure, topology and assembly of a 32-mer peptide corresponding to the loop 3 and transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environments, Journal of Inorganic Biochemistry . 2008, 102: 1257-1266.

 

Li H., Sze K.H. and Sun H., Validation Inter-helical Orientation of the Sterile-a-Motif Domain of the Delected in Liver Cancer 2(DLC2-SAM) by Residual Couplings , International Comferene in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A18.

 

Qi S., Sun H. and Huang J., Expression of Mutated Hpn - a Nickel Binding Protein from Helicobacter Pylori, 12th Research Postgraduate Symposium, December 12 & 14, 2007.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Ge R. and Cun S., Identification of bismuth-binding proteins in Helicobacter pylori by a metalloproteomic approach, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun H., Invited lecture, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Invited lecture, International Conference in Structural Biology, Hong Kong, November 19-22. 2007.

 

Sun H., Invited lecture, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun H., Member of Editorial Advisory Board , The Open Medicinal Chemistry Journal. Bentham Science Publisher, 2007.

 

Sun H., Choy T.S.J., Yam W.C., Ng S.P. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Assay of Low E.coli count in Water, The 10th World Congress on Biosensors . 2008, P1.158.

 

Sun H., Yam W.C., Ng S.P., Li Z. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Detection of E. Coli in Environmental Water , Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007 . 2007, p41, pp71.

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Sun H., Seminar on Metallomics and Metalloproteomics, Institute of High Energy Physics, the Chinese Academy of Sciences, April 25, Beijing, China, 2008.

 

Sun H. and Fung Y.S., Separation and Determination of Carbonyls by Gradient Elution Micellar Electrokinetic Capillary Chromatography , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:61, pp 5:145.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Wang H., Li H., Cai B., Huang Z. and Sun H., The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein, Journal of Biological Inorganic Chemistry. 2008, 13: 411-419.

 

Yang N. and Sun H., Biocoordination chemistry of bismuth: recent advances, Coordination Chemistry Reviews. 2007, 251: 2354-2366.

 

Yang N., Tanner J.A., Zheng B., Watt R.M., He M.L., Lu L., Jiang J., Shum K.T., Lin Y., Wong K.L., Lin M.C., Kung H.F., Sun H. and Huang J., Bismuth complexes inhibit the SARS coronavirus, Angewandte Chemie International Edition. 2007, 46: 6464-6468.

 

Yang N., Tanner J.A., Wang Z., Huang J., Zheng B., Zhu N. and Sun H., Inhibition of SARS coronavirus helicase by bismuth complexes, Chemical Communications. 2007, 4413-4415.

 

Yang N., Tanner J.A., Huang J., Zheng B. and Sun H., Inhibition of the SARS coronavirus by Bismuth Compounds, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Yang Z., Wang X., Diao H., Zhang J., Li H., Sun H. and Guo J., Encapsulation of platinum anticancer drugs by apoferritin, Chemical Communications. 2007, 3453-3455.

 

Zeng Y., Zhang D. and Sun H., Overexpression and Characterization of a Histidine- and Glutamine-rich Protein, Hpn-like, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Zhu D., Sun H. and Fung Y.S., Electrodeposition of Tin from the 1-Methyl-3-Ethyllimidazolium Chloride/AlCl3SnCl2 Room Temperature Molten Salts , Electrochemical Society Transactions . 2007, 3: 239-248.

 

Researcher : Sun H



List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Cun S., Li H., Ge R., Lin M.C. and Sun H., A Histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility., Journal of Biological Chemistry. 2008, 283: 15142-15151.

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Ding Z.C., Zheng Q., Cai B., Yu W.H., Teng X.C., Wang Y., Zhou G.M., Wu H.M., Sun H., Zhang M.J. and Huang Z.X., Effect of a-domain Substitution on the Structure, Propety and Function of Human Neuronal Growth Inhibitory Factor , Journal of Biological Inorganic Chemistry. 2007, 1173-1179.

 

He J., Hu P., Wang Y.J., Tong M.L., Sun H., Mao Z.W. and Ji L.N., Double-strand DNA cleavage by copper complexws of 2,2'-dipyridyl with guanidinium / ammonium pendants , Dalton Transactions. 2008, 3207-3214.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Li H., Gu J.D. and Sun H., Structure, topology and assembly of a 32-mer peptide corresponding to the loop 3 and transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environments, Journal of Inorganic Biochemistry . 2008, 102: 1257-1266.

 

Li H., Sze K.H. and Sun H., Validation Inter-helical Orientation of the Sterile-a-Motif Domain of the Delected in Liver Cancer 2(DLC2-SAM) by Residual Couplings , International Comferene in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A18.

 

Qi S., Sun H. and Huang J., Expression of Mutated Hpn - a Nickel Binding Protein from Helicobacter Pylori, 12th Research Postgraduate Symposium, December 12 & 14, 2007.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Ge R. and Cun S., Identification of bismuth-binding proteins in Helicobacter pylori by a metalloproteomic approach, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun H., Invited lecture, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Sun H., Invited lecture, International Conference in Structural Biology, Hong Kong, November 19-22. 2007.

 

Sun H., Invited lecture, International Symposium on Metallomics 2007 (ISM2007), Nagoya, Japan, November 28- December 1. 2007.

 

Sun H., Member of Editorial Advisory Board , The Open Medicinal Chemistry Journal. Bentham Science Publisher, 2007.

 

Sun H., Choy T.S.J., Yam W.C., Ng S.P. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Assay of Low E.coli count in Water, The 10th World Congress on Biosensors . 2008, P1.158.

 

Sun H., Yam W.C., Ng S.P., Li Z. and Fung Y.S., Nano-silver Modified Nucleic Acid / Piezoelectric Quartz Crystal Biosensor for Detection of E. Coli in Environmental Water , Abstract of 3rd International Workshop on Biosensors for Food Safety and Environmetnal Monitoring, Fez, Morocco, October 18-20, 2007 . 2007, p41, pp71.

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Sun H., Seminar on Metallomics and Metalloproteomics, Institute of High Energy Physics, the Chinese Academy of Sciences, April 25, Beijing, China, 2008.

 

Sun H. and Fung Y.S., Separation and Determination of Carbonyls by Gradient Elution Micellar Electrokinetic Capillary Chromatography , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:61, pp 5:145.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Wang H., Li H., Cai B., Huang Z. and Sun H., The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein, Journal of Biological Inorganic Chemistry. 2008, 13: 411-419.

 

Yang N. and Sun H., Biocoordination chemistry of bismuth: recent advances, Coordination Chemistry Reviews. 2007, 251: 2354-2366.

 

Yang N., Tanner J.A., Zheng B., Watt R.M., He M.L., Lu L., Jiang J., Shum K.T., Lin Y., Wong K.L., Lin M.C., Kung H.F., Sun H. and Huang J., Bismuth complexes inhibit the SARS coronavirus, Angewandte Chemie International Edition. 2007, 46: 6464-6468.

 

Yang N., Tanner J.A., Wang Z., Huang J., Zheng B., Zhu N. and Sun H., Inhibition of SARS coronavirus helicase by bismuth complexes, Chemical Communications. 2007, 4413-4415.

 

Yang N., Tanner J.A., Huang J., Zheng B. and Sun H., Inhibition of the SARS coronavirus by Bismuth Compounds, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Yang Z., Wang X., Diao H., Zhang J., Li H., Sun H. and Guo J., Encapsulation of platinum anticancer drugs by apoferritin, Chemical Communications. 2007, 3453-3455.

 

Zeng Y., Zhang D. and Sun H., Overexpression and Characterization of a Histidine- and Glutamine-rich Protein, Hpn-like, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Zhu D., Sun H. and Fung Y.S., Electrodeposition of Tin from the 1-Methyl-3-Ethyllimidazolium Chloride/AlCl3SnCl2 Room Temperature Molten Salts , Electrochemical Society Transactions . 2007, 3: 239-248.

 

Researcher : Sun RWY



List of Research Outputs

 

Sun R.W.Y., Invited Lecture - Metal-based Therapeutics at the Centre for Drug Safety Evaluation & Research in Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China. 2008.

 

Sun R.W.Y., Ma D.L., Wong E.L.M. and Che C.M., Some Uses of Transition Metal Complexes as Anti-cancer and Anti-HIV Agents , Dalton Transactions. 2008, 4884-4892.

 

Wang Y., He Q.Y., Che C.M., Tsao G.S.W., Sun R.W.Y. and Chiu J., Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways, Biochemical Pharmacology. 2008, 75: 1282-1291.

 

Researcher : Sun X



List of Research Outputs

 

Sun X., Chiu J. and He Q.Y., Fractionation of proteins by immobilized metal affinity chromatography, In: A. Posch, Methods in Molecular Biology. U. S. A., Human Press, 2008, 424: 205-212.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Researcher : Sun X



List of Research Outputs

 

Sun X., Chiu J. and He Q.Y., Fractionation of proteins by immobilized metal affinity chromatography, In: A. Posch, Methods in Molecular Biology. U. S. A., Human Press, 2008, 424: 205-212.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-Based Drugs. 2008, 2008 Article ID 289490: 6 pages.

 

Sun X., Ge R., Chiu J., Sun H. and He Q., Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis, Metal-based Drug. 2007, 289890-1 to 289890-6.

 

Sun X., Ge R., Chiu J., Sun H. and He Q.Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion, FEBS Letters. 2008, 582: 1351-1354.

 

Researcher : Sun Z



List of Research Outputs

 

Sun Z., Liu F., Chen Y., Tam P.K.H. and Yang D., A Highly Specific BODIPY-based Fluorescent Probe for the Detection of Hypochlorous Acid, Organic Letters. 2008, 10(11): 2171-2174.

 

Sun Z., Yang D., Chen Y. and Liu F., Reagents for Detection of Hypochlorous Acid, U.S. Non-Provisional Patent Application (No. 12/034,670). 2008.

 

Researcher : Sy LK



Project Title:

Structural elucidation and biological study of polysaccharides isolated from traditional Chinese medicines

Investigator(s):

Sy LK, Che CM, Man RYK

Department:

Pharmacology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study the sequence, branching and conformational structures of the polysaccharides isolated from Traditional Chinese Medicines.

 

 

Researcher : Sze J



List of Research Outputs

 

Sze J., Flow Cytometry, Kunming University of Medical Sciences; 9 July 2007. 2007.

 

Researcher : Sze KH



Project Title:

Development and application of NMR methods based on solvent exposed amides (SEA) experiments for proteins

Investigator(s):

Sze KH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2004

 

Abstract:

To resolve overlapping resonances in the NMR spectra of proteins; to map the protein-protein, protein-nucleic acid or protein-ligand interaction sites; to study unfolding/folding pathway of proteins.

 

Project Title:

Structural and functional studies of human XIAP-associated factor 1 (XAF1) by NMR Spectroscopy

Investigator(s):

Sze KH

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

05/2006

 

Abstract:

Apoptosis, referring to the biological process of programmed cell death, plays an essential role in developmental and cellular homeostasis of mammalian cells (1). Dysfunction of the process leads to a number of human pathologies, including cancer, autoimmune diseases, and neurodegenerative disorders (2-6). The molecular pathway of apoptosis is evolutionarily conserved and the initiation, execution, and regulation of apotosis pathway are governed by hundreds of genes. The process culminates in the activation of caspases cascade to degrade the cellular machinery (e.g. Chromosome) (7,8). Research in the past two decades has led to the identification of several caspases-inhibiting proteins. Deregulation of these proteins may confer apoptosis resistance and results in low sensitivity of cancer cell to therapeutic agents (1). The X-linked Inhibitor of Apoptosis (XIAP), belonging to the family of intrinsic inhibitor apoptosis protein (IAP), is a newly discovered key caspases-inhibiting protein (9). The XIAP was demonstrated to be an endogenous repressor, which blocks the activity of the caspases in the terminal part of the cascade in vitro (9). In turns, the caspases-inhibiting activity of the XIAP is negatively controlled by two XIAP-binding proteins, namely Smac/DIABLO (10-15) and XAF1 (XIAP-associated factor 1)(16). In contrast to Smac/DIABLO, the structural and biochemical basis of XAF1 remain to be determined. It was reported that XAF1, which antagonizes recombinant XIAP in vitro, normally reside in the nucleus of the cell. Overexpression of XAF1 was shown to trigger the redistribution of cytoplamic XIAP to the nucleus, leading to XIAP-suppression, caspases activation and apoptosis (9). On the other hands, the loss of endogenous XAF1, by utilizing the adenovirus infection of antisense XAF1 mRNA, was reported to enhance cellular resistance to apoptosis (16). It is believed that XAF1 was a putative tumor suppressor gene (17). XAF1 is ubiquitously expressed in normal tissue, but present at low level or undetectable levels in nucleus and cytoplasm of different cancer cell lines (18). It was recently showed that the aberrant reduction of XAF1 transcription, but not Smac/DIABLO, in gastric adenocarcinomas might be attributed to the hypermethylation of seven CpGs in the promoter region of XAF1 gene locus (17). A low concentration of cellular XAF1 transcription was also observed in human colorectal cancer (19). In addition to the tumor suppressing behavior, XAF1 was reported to enhance neuronal susceptibility toward degeneration in reperfusion injury after ischemia (20). Nevertheless, the pathophysiological mechanism of XAF1 is still not clear. XAF1 is a 37kDa nuclear protein, comprising of 317 amino acids and having two mRNA spicing variants (16). The domain architecture and structure of XAF1 is unknown. Sequencing analysis of the nuclear protein revealed the existence of TRAF zinc finger within H23-E99. Overexpression of the Zinc-finger portion blocked INF (Interferon)-dependent sensitization of A375 melanoma cell to the pro-apoptotic effect of TRAIL, which is a tumor necrosis factor related apoptosis inducing ligand(21). The domains responsible for XIAP binding and compartmental translocation are yet to be identified. The objectives of this research are: (I) Dissecting the functional domain architecture of full-length XAF1, identifying the domain (XBD) in XAF1 responsible for XIAP binding and the corresponding XIAP domain for XAF1 binding. (II) Determining the solution structure of XIAP-binding domain in XAF1 by biomolecular NMR spectroscopy. (III) Determining the solution structure of XIAP/XAF1 domains complex. We have carried out preliminary research on the proposed project including the different truncated GST-fusion XAF1 have been identified and subcloned into the pGEX-4T-1 vector. Bacterial expressions of different fragments have been tried in BL21 (DE3) host and the expression conditions have been worked out. The expression level of the fragments was as high as 10mg/L. This is suitable for structural studies with NMR spectroscopy, which requires large quantities of isotopic labelled protein samples. Reference 1. Danial NN, Korsmeyer SJ. 2004.Cell death: critical control points. Cell 116:205 .19 2. Green DR, Evan GI. 2002. A matter of life and death. Cancer Cell 1:19 .30 3. Hanahan D, Weinberg RA. 2000.The hallmarks of cancer. Cell 100:57 .70 4. Thompson CB.1995.Apoptosis in the pathogenesis and treatment of disease. Science 267:1456 –62 5. Vaux DL,Flavell RA.2000. Apoptosis genes and autoimmunity. Curr Opin.Immunol. 12:719-24 6. Yuan J, Yankner BA.2000.Apoptosis in the nervous system. Nature 407:802 .9 7. Riedl SJ, Shi Y. 2004. Molecular mechanisms of caspase regulation during apoptosis.Nat.Rev. Mol.Cell.Biol.5: 897-907 8. Thornberry NA, Lazebnik Y.1998.Caspases: enemies within. Science 281:1312 .16 9. Holcik M, Gibson H, Korneluk RG. 2001. XIAP: apoptotic brake and promising therapeutic target. Apoptosis.6: 253-61. 10. Du C, Fang M, Li Y, Li L, Wang X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:33–42. 11. Verhagen AM, et al.. 2000.Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell; 102:43–53. 12. Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. 2000. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 406: 855–862. 13. Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES. 2000. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem. 275: 36152–36157. 14. Wu G, et al. Structural basis of IAP recognition by Smac/DIABLO. 2000. Nature. 408: 1008–1012. 15. Liu Z, et al. 2000.Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 408: 1004–1008. 16. Liston P, et al. 2001.Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nature Cell Biology. 3: 128–133. 17. Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG. 2003. Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res.63: 7068-75. 18. Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG. 2000. Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics. 70: 113–122. 19. Ma TL, Ni PH, Zhong J, Tan JH, Qiao MM, Jiang SH.2005. Low expression of XIAP-associated factor 1 in human colorectal cancers. Chin J Dig Dis.6: 10-4. 20. Siegelin M, Touzani O, Toutain J, Liston P, Rami A.2005.Induction and redistribution of XAF1, a new antagonist of XIAP in the rat brain after transient focal ischemia. Neurobiol Dis.20: 509-18. 21. Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC. 2002.Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. J Biol Chem. 277: 28504-11.

 

Project Title:

Structural and functional studies of the SWIRM domain in Lysine-specific Demethylase 1 (LSD1)

Investigator(s):

Sze KH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

(1) Determination of the solution structure and backbone dynamics of swirm domain in LSD1; (2) characterization of the functional role of swirm domain in LSD1.

 

Project Title:

Structural and Functional Studies of the Kringle 1 domain of hepatocyte growth factor (HGFK1) by NMR Spectroscopy

Investigator(s):

Sze KH, Lin MC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

Hepatocyte growth factor (HGF) (1-7), also known as scatter factor (SF), is a vertebrate-specific polypeptide growth factor that plays an important role in complex biological processes such as embryogenesis, tissue regeneration, cancerogenesis and angiogenesis. HGF promotes cell proliferation, survival, migration and morphogenesis of endothelial cells (EC) through binding to tyrosine kinase MET receptor. Interest in HGF/SF and its receptor MET (8) stems from their unique biological roles in embryogenesis, tissue regeneration, and cancer (9–14). These activities have led to a strong interest in the structure of the molecules as this knowledge may underpin the development of MET-based therapeutics. HGF consists of six domains: an N-terminal domain (N), four copies of the kringle domain (K1–K4), and a C-terminal domain (sp) structurally related to the catalytic domain of serine proteinases. The factor is synthesized as a precursor protein of single-chain HGF (sc-HGF) and is proteolytically processed to a two-chain form (tc-HGF) by cleavage of the linker at a trypsin-like site connecting the K4 and sp domains by hepatocyte growth factor activator (HGFA). Sc-HGF binds MET (15, 16) but is unable to induce biological responses. MET consists of an N-terminal sema domain, which is responsible for ligand binding, and four copies of Ig-like domains. The sema and Ig-like domains are joined by cystine-rich domain (cr). MET receptor is initially synthesized as a partially glycosylated single-chain intracellular precursor. The precursor is subsequently cleaved by furin, yielding an extracellular α-chain and a β-chain which spans the membrane. The structural basis of the conversion of single-chain to two-chain HGF is unknown. The whole picture of HGF-induced MET signaling is unclear until the overall architecture of HGF and MET are obtained by cryo-EM and SAXS recently (17). Interestingly, the low resolution images of structures for single-chain HGF precursor (sc-HGF) and two-chain HGF (tc-HGF) displayed by cryo-EM differ markedly, where sc-HGF appears as ring-shaped, closed structure, while tc-HGF appears as elongated, open conformation. HGF is in equilibrium between the closed and elongated conformation. In the presence of MET receptor, the equilibrium shifts toward the open form (i.e. tc-HGF). The receptor binding sites of HGF are located in K1 and sp domains. For sc-HGF, the receptor binding sites are too close to each other, thus sc-HGF is unable to effectively binding MET due to steric hindrance. In contrast, the elongated form of tc-HGF allows it to wrap around the α-chain of MET928 (full-length MET) in form of a monomeric 1:1 complex. The N and K1 domains bind the ‘a’ face of MET928. K2 and K3 domains cross the side face, leaving K4 on top of sp domain which binds on the ‘b’ face of MET928. The soluble recombinant protein kringle 1 domain of human hepatocyte growth factor (HGFK1), which includes 88 residues from 127-214 of HGF, has been reported to inhibit the proliferation of bovine aortic endothelial (BAE) cell stimulated by basic fibroblast growth factor (bFGF) in a dose-dependent manner (18). It has been shown that the recombinant HGFK1 protein is a much more effective anti-angiogenesis molecule than angiostatin in vitro in cell culture system (18). We have recently evaluated the utility of a recombinant adeno-associated virus carrying the HGFK1 gene in treating hepatocellular carcinoma (HCC), a highly metastatic cancer. Hepatocellular carcinoma is a hypervascular tumor associated with a poor prognosis and a lack of effective treatments. Consequently, identifying novel therapeutic strategies are urgently needed. We constructed a recombinant adeno-associated virus carrying the HGFK1 gene (rAAV-HGFK1) and administered it to a syngenic orthotopic rat model of HCC by intra-tumoral and intra-portal injections. Results showed that rAAV-HGFK1 inhibited tumor growth, decreased microvessel density in the tumor, and completely prevented intra-hepatic, lung, and peritoneal metastasis. rAAV-HGFK1 was able to mediate long-term expression of HGFK1 and markedly prolong the median survival time of HCC-bearing rats. Moreover, high doses of rAAV-HGFK1 were not toxic to the animal. In vitro experiments further demonstrated that rAAV-HGFK1 affected mice microvessel endothelial cells (EC) by inducing apoptosis and inhibiting EC proliferation and tube formation. Furthermore, rAAV-HGFK1 exerted its effect by a mechanism entirely different from that previously reported for endostatin. It induced EC apoptosis via the up-regulation of β-amyloid binding protein (BBP), as knocking down BBP gene expression prevented rAAV-HGFK1 induced EC apoptosis. In conclusion, this study demonstrates that rAAV-HGFK1 anti-angiogenic gene therapy is a novel and promising approach for the treatment of HCC, and that the anti-angiogenic effect of HGFK1 is dependent on the BBP signal apoptotic transduction pathway. We further showed that HGFK1 is essential and sufficient to induce growth signals transduced by HGF, EGF, and VEGF. Since HGFK1 is a fragment of HGF, which potentially has an oncogenic effect, the therapeutic efficacy, possible hepatic cytotoxicity, and the molecular mechanism of action requires careful evaluation. In particular, we aim to: 1. Determine the solution structure and backbone dynamics of HGFK1 2. Characterize the interaction domain of the MET receptor with HGFK1 References: 1. Gherardi, E., et al. (1989) Proc. Natl. Acad. Sci. USA 86, 5844–5848. 2. Nakamura, T., et al. (1989) Nature 342, 440–443. 3. Miyazawa, K., et al. (1989) Biochem. Biophys. Res. Commun. 163, 967–973. 4. Stoker, M., et al. (1987) Nature 327, 239–242. 5. Weidner, K.M., et al. (1991) Proc. Natl. Acad. Sci. USA 88, 7001–7005. 6. Gherardi, E. & Stoker, M. (1990) Nature 346, 228 (lett.). 7. Donate, L.E., et al. (1994) Protein Sci. 3, 2378–2394. 8. Bottaro, D. P., et al. (1991) Science 251, 802–804. 9. Schmidt, C., et al. (1995) Nature 373, 699–702. 10. Uehara, Y., et al. (1995) Nature 373, 702–705. 11. Bladt, F., et al. (1995) Nature 376, 768–771. 12. Huh, C.G, et al.. (2004) Proc. Natl. Acad. Sci. USA 101, 4477–4482. 13. Borowiak, M., et al. (2004) Proc. Natl. Acad. Sci. USA 101, 10608–10613. 14. Birchmeier, C., et al. (2003) Nat. Rev. Mol. Cell Biol. 4, 915–925. 15. Gherardi, E., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 12039–12044. 16. Lokker, N.A., et al. J. B. & Godowski, P. J. (1992) EMBO J. 11, 2503–2510. 17. Gherardi E, et al. . (2006) Proc. Natl. Acad. Sci. USA 103, 4046-4051. 18. Li Xin, et al. (2000) Biochemical And Biophysical Research Communications 277 (1): 186-190.

 

List of Research Outputs

 

Chan D.S.B., Chu L.O., Lee K.M., Too P.H.M., Ma K.W., Zhu G., Shaw P.C., Wong K.B. and Sze K.H., Interaction Between Trichosanthin, a Ribosome-inactivating Protein, and the Ribosomal Stalk Protein P2 by Chemical Shift Perturbatiuon and Mutagenesis Analyses, Internationa Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A14.

 

Cho C.K.L., Yang Y., Chu I.K., Haynes R.K. and Sze K.H., 3D Structure Determination and Comparison of Natural Loloatin Family and all L-loloatins by Nuclear Magnetic Resonance Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-18.

 

Guan X., Wong K.B. and Sze K.H., Dynamics Study of a Thermophilic Acyphosphatase and its Mutants from Pyrococcus Horikoshii by NMR Spectroscopy , International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A06.

 

Guan X., Wong K.B. and Sze K.H., Structure and Dynamics of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy -- Structural Basis of Thermostability and Enzymatic Activities , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-19.

 

Hui S.K., Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Funtional Study of a 9kDa a-heical Domain of BIR3-RING Linker Region in XIAP Protein by NMR Spectroscopy, Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E21.

 

Jiang M., Chen M., Cao Y., Yang Y., Sze K.H., Chen X. and Guo Z., Determination of the Stereochemistry of 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a Key Intermediate in Menaquinone Buisynthesis , Organic Letters. 2007, 9: 4765-4767.

 

Lai P.M., Yao H., Wong A.O.L. and Sze K.H., Structure and Functional Study of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), The Fifiennth Symposium on Chemistry Postgraduate Research in Hong Kong. The University of Hong Kong, Hong Kong, April 26, 2008.

 

Li H., Sze K.H. and Sun H., Validation Inter-helical Orientation of the Sterile-a-Motif Domain of the Delected in Liver Cancer 2(DLC2-SAM) by Residual Couplings , International Comferene in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A18.

 

Lo C.S.C., Le Blanc J.C.Y., Yu K.Y., Sze K.H., Ng D.C.M. and Chu I.K., Detection, Characterization, and Quantification or Resveratrol Glycosides in Transgenic Arabidopsis Over-expressing a Sorghum Stibene Synthase Gene by Liquid Chromatography / Tandem Mass Spectrometry , Rapid Communications in Mass Spectrometry . 2007, 21: 4101-4108.

 

Mak A., Wong Y.T., Am Y.J., Cha S.S., Sze K.H., Au S., Wong K.B. and Shaw P.C., Structure-function Study of Maize Ribosome-inactivating Protein: Implications for the Internal inactivation Region and the Sole Glutamate in the Active Site , International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A24.

 

Mak A.N.S., Wong Y.T., An J.Y., Cha S.S., Sze K.H., Au S.W.N., Wong K.B. and Shaw P.C., Strucutre-functions Study Of Maize Ribosome - Inactivating Protein: Implications For The Internal Inactivation Region And The Sole Glutamate In The Active Site , Nucleic Acids Research . 2007, 35: 6259-6267.

 

Shaw P.C., Wong K.B., Too P.H.M., Chan D.S.B., Zhu G. and Sze K.H., How Does Trichosanthin, a Ribosome-inactivation Protein, Find the Target Site on Ribosome? , Enzyme Engineering Conference, Dalian, China, July 22-27, 2007.

 

Shen Z., Yang Z., Gao Y., Li J.C., Chen H.X., Liu C.C., Poon R.T.P., Fan S.T., Luk J.M.C., Sze K.H., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Cancer Research. 2008, 68: 404-414.

 

Sze K.H., Wong A.O.L., Yang Y., Zhou H., He M. and Sze K.H., A Brain-specific PACAP in Fish Model: Solution Structure by Nuclear Magnetic Resonance Spectroscopy and Effects on Growth Hormone Release and Gene Expression, International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007 . 2007.

 

Sze K.H., Characterization and Structural Studies of X-Linked Inhibitor of Apoptosis Protein-Associated Factor 1 (XAF1), Invited lecture on International Conferene in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007 . 2007, S26.

 

Sze K.H., Zhou H., Yang Y., He M., Jiang Y.H. and Wong A.O.L., Pituitary Adenyate Cyclase-Activating Polypeptide (PACPS) as a Growth Hormone (GH)-Releasing Factor in Grass Carp: II. Soution Structure of Brain-Specific PACAP by Nuclear Magnetic Respmamce Spectroscopy and Functiona Studies on GH Release and Gene Expression, Endocrinology . 2007, 148: 5042-5059.

 

Sze K.H., Resonance Assignments of the 27kDa Active form of Maize Ribosone-Inactivating Protein (MOD) by NMR Spectroscopy , Invited lecture on 16th Triennial Conference for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. 2007, P1-15.

 

Sze K.H., Scientific Journals International, 2008.

 

Tse H.S., Hu Y.H. and Sze K.H., Structure and Dynamics Studies of a Novel Ubiquitin Carboxyl Terminall Hydrolase by NMR Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-17.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Biophysical Characterization of a 13kDa Structural Domain in XAF1 Protein , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-20.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Functional Study of XIAP-Associated Factor 1 (XAF1) - Identification and Characterization of a 13kDa Structural Domain , 16th Triennial Conference for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. P1-17.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Structural and function Stude of XIAP-Associated Flactor1 (SFA__P), International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A37.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Resonance Assignments of the 27kDa Active from of Maize Ribosone-Inactivating Protein (MOD) by NMR Spectroscopy, Poster Presentation on 16th Triennial Conferenc for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. P1-15.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Solution Structure of a 28 kDa active Mutant of Maize Ribosome-Inactivating Protein (MOD) Studied by NMR Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-19.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., 1H, 13C and 15N Backbone and Side Chain Resonance Assignments of a 28 kDa Active Mutant of Maize Ribosome-inactivating Protein (MOD) , Biomolecular NMR Assignments . 2007, 12: 187-189.

 

Researcher : Sze KL



List of Research Outputs

 

Fung Y.S., Wong C.C.W., Choy T.S.J. and Sze K.L., Determination of Sulphate in Water by flow-injection Analysis with Electrode-separated Piezolectric Quartz Crystal Sensor , Sensors and Actuators B . 2008, 130: 551-560.

 

Sze K.L. and Fung Y.S., Capillary Electrophoresis for the Determination of Trace Metals in milk , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:59, pp 5:144.

 

Sze K.L., Yeung W.S.B. and Fung Y.S., Separation and Determination of Metal Cations in Milk and Dairy Products by CE, Electrophoresis. 2007, 28: 4156-4163.

 

Researcher : Sze KL



List of Research Outputs

 

Fung Y.S., Wong C.C.W., Choy T.S.J. and Sze K.L., Determination of Sulphate in Water by flow-injection Analysis with Electrode-separated Piezolectric Quartz Crystal Sensor , Sensors and Actuators B . 2008, 130: 551-560.

 

Sze K.L. and Fung Y.S., Capillary Electrophoresis for the Determination of Trace Metals in milk , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007 . 2007, Paper 5:59, pp 5:144.

 

Sze K.L., Yeung W.S.B. and Fung Y.S., Separation and Determination of Metal Cations in Milk and Dairy Products by CE, Electrophoresis. 2007, 28: 4156-4163.

 

Researcher : Sze-To L



List of Research Outputs

 

Wong S.Y., Gu Y., Sze-To L. and Wong W.T., An Open-channel Architecture Assembly from the [Os3(CO)8{m-h3-ON=CPh(NC5H4)}2] Cluster , Crystengcomm. 2008, 10: 29-33.

 

Researcher : Tam WY



List of Research Outputs

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Leung Q.Y., Mak S.K., Tam W.Y. and Chan W.K., Fabrication of Rhenium Containing Narrow Band Gap Polymer for Photovoltaic Applications , Abstract of Europolymer Confernece, 2008, Gargnano (BS-Italy), June 1-5, 2008. Gargnano, Italy, Poster ref. P.30.

 

Ng M.C.A., Djurisic A., Tam K.H., Kwok W.M., Chan W.K., Tam W.Y., Phillips D.L. and Cheah K.W., Organic nanoclusters on inorganic nanostructures for tailoring the emission properties of organic materials, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 566-574.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Researcher : Tam WY



List of Research Outputs

 

Chan W.K., Cheng K.W., Mak S.K. and Tam W.Y., Metal Containing Polymers with Wide Absorption Range For Photovoltaic Applications, American Chemical Society 234th National Meeting, Boston, USA, August 19-23, 2007. . 2007.

 

Chan W.K., Cheng K.W., Mak S.K., Tam W.Y. and Djurisic A., Metal containing polymers with wide absorption range for photovoltaic applications, Polymer Preprints. America, ACS, 2007, 48: 581-582.

 

Leung Q.Y., Mak S.K., Tam W.Y. and Chan W.K., Fabrication of Rhenium Containing Narrow Band Gap Polymer for Photovoltaic Applications , Abstract of Europolymer Confernece, 2008, Gargnano (BS-Italy), June 1-5, 2008. Gargnano, Italy, Poster ref. P.30.

 

Ng M.C.A., Djurisic A., Tam K.H., Kwok W.M., Chan W.K., Tam W.Y., Phillips D.L. and Cheah K.W., Organic nanoclusters on inorganic nanostructures for tailoring the emission properties of organic materials, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2008, 18: 566-574.

 

Tam W.Y., Mak S.K., Leung Q.Y., Cheng K.W. and Chan W.K., Novel Metal Containing Diablcok Copolymers for Photovoltaic Application , Abstract of Europolymer Conference 2008, Gargnano (BS-Italy), June 1-5, 2008. Poster ref. P51.

 

Researcher : Tam YY



List of Research Outputs

 

Tam Y.Y., Lam S.W.H., Wong M.C., Zhu N. and Yam V.W.W., Luminescent Alkynylplatinum(II) Complexes of 2,6-Bis (N-alkylbenzimidazol-2'-yl) Pyridine-Type Ligands with Ready Tunability of the Nature of the Emissive States by Solvent and Electronic Property Modulation , Chemistry - A European Journal. 2008, 14: 4562-4576.

 

Researcher : Tang HW



List of Research Outputs

 

Tang H.W., Ng K.M., Liang Z.T., Che C.M., Cheng Y.C. and Zhao Z.Z., Histochemical Analysis of Medicinal Plants by Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry, 6th Meeting of Consortium for Globalization of Chinese Medicine, Beijing, China. 2007.

 

Tang H.W., Ng K.M. and Che C.M., Internal Energy Transfer in Carbon-based Surface-Assisted Laser Desorption/Ionization: Graphite versus Diamond, The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Colorado Convention Center, Denver, Colorado, U.S.A.. 2008, ThP085.

 

Researcher : Tang HW



List of Research Outputs

 

Tang H.W., Ng K.M., Liang Z.T., Che C.M., Cheng Y.C. and Zhao Z.Z., Histochemical Analysis of Medicinal Plants by Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry, 6th Meeting of Consortium for Globalization of Chinese Medicine, Beijing, China. 2007.

 

Tang H.W., Ng K.M. and Che C.M., Internal Energy Transfer in Carbon-based Surface-Assisted Laser Desorption/Ionization: Graphite versus Diamond, The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Colorado Convention Center, Denver, Colorado, U.S.A.. 2008, ThP085.

 

Researcher : Tao CH



Project Title:

Luminescent transition metal complexes with branched alkynyls

Investigator(s):

Tao CH, Yam VWW

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

The research of organic polymeric materials is undoubtedly one of the most active areas of research in chemistry, especially during the past decade, due to their intriguing physical properties, ease of fabrication and wide range of applications. The search for new advanced and multifunctional materials has boosted the development of copolymers or block copolymers which have enhanced properties. However, the solubility and processability of linear polymers usually decrease with increasing molecular weight and this has limited their applications.Dendrimers, which constitute a novel class of highly branched three-dimensional macromolecules, and branched molecules are currently attracting widespread interest in many areas of science and technology mainly due to their relatively high solubilities and better processabilities compared to the rod-like counterparts. A considerable number of organic two-dimensional and three-dimensional architectures have also been built using the chemistry of the alkynyl units using well-established reaction protocols.Transition metal systems possess interesting properties which are inaccessible with pure organic dendrimers or branched molecules. Thus, numerous surface-modified metallodendrimers have been reported in the last decade, in which their applications as catalysts and sensors were reported. Compared with the above mentioned metallodendrimers, the research on synthesis of sigma-bonded organometallic dendrimers with metal-carbon bonds is still less explored probably due to the lack of appropriate building blocks and difficulties in product isolation. In fact, the alkynyl group is known for its ability to interact with transition metal centers through pπ-dπ overlap and appears to be a promising candidate for the construction of carbon-rich metal-containing materials while its inherent rigidity would be beneficial in the preparation of luminescent materials.In this regard, a convenient and high yield synthetic protocol is needed for coupling highly luminescent transition metal centers with rigid phenylene ethynylene backbones. The proposed project would explore the possibility of acquiring luminescent materials with relatively high solubilities and good processabilities via different synthetic routes. Various platinum and rhenium complexes of branched alkynyls would be designed which, similar to organic dendrimers, could be synthesized via a divergent or convergent approach. The divergent synthesis of the branched alkynyl complexes would involve reactions between branched phenylene ethynylene alkynyl ligands and metal halide precursors. On the other hand, the convergent approach would adopt "metalloligand" coupling reactions between terminal alkynyls and aryl halides. It is envisioned that these branched multinuclear alkynyl complexes are highly luminescent and possess better solubility and processability when compared with their rod-like counterparts.Besides, the terminal positions of the alkynyl ligands can be selectively deprotected and may serve as ideal candidate for the synthesis of mixed-metal complexes. Further research on the study of energy transfer properties in these branched mixed-metal alkynyl complexes would yield directional energy transfer materials which mimics the energy transfer processes in photosynthesis.

 

List of Research Outputs

 

de Montigny F., Argouarch G., Roisnel T., Toupet L., Lapinte C., Lam C.F., Tao C.H. and Yam V.W.W., Syntheses, Structures, and Properties of Some Piano-stool Iron Acetylides Bearing a Functional Anthracenyl Group, Organometallics. 2008, 27: 1912-1923.

 

Researcher : Ting SW



List of Research Outputs

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Researcher : Tong HY



List of Research Outputs

 

Xu S., Wong C.L., Tong H.Y., Chung S.S.M. and Ko C.B., Phosphorylation By Casein Kinase 1 Regulates Tonicity-induced Osmotic Reponse Element-binding Protein/tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking, Journal Of Biological Chemistry. 2008, 283: 17624-34.

 

Researcher : Tong SM



Project Title:

High-valent iron porphyrins

Investigator(s):

Tong SM, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To investigate if dioxoiron (VI) porphyrin complex participates in the biological cycles of oxygen activation.

 

List of Research Outputs

 

Tong S.M., Wong E.L.M. and Che C.M., Density Functional Theory Study of trans-Dioxo Complexes of Iron, Ruthenium, and Osmium with Saturated Amine Ligands, trans-[M(O)2(NH3)2(NMeH2)2]2+ (M=Fe, Ru, Os), and Detection of [Fe(qpy)(O)2]n+ (n=1, 2) by High-Resolution ESI Mass Spectrometry, Chemistry - A European Journal. 2008, 14: 5495-5506.

 

Researcher : Toy PH



Project Title:

The development of tetrahydrofuran based polymers for polymer assisted organic synthesis

Investigator(s):

Toy PH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To synthesize and characterize novel cross-linked tetrahydrofuran based polymers using cationic, anionic and ring-opening metathesis polymerization strategies; to assess the utility of the new polymers in both solid-phase and solution-phase organic synthesis in order to study the optimum polymer structure and morphology in such applications.

 

Project Title:

Organocatalytic Mitsunobu Reactions

Investigator(s):

Toy PH

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

The objective of the proposed project is to develop catalytic versions of the Mitsunobu reaction. The Mitsunobu reaction is a powerful tool in organic synthesis that is used to make covalent bonds between carbon atoms at atoms such as oxygen, nitrogen and even other carbon atoms. Unfortunately Mitsunobu reactions currently suffer from the fact that they require the use of large amounts of 2 chemical reagents that are often difficult to remove from the reaction mixtures at the end of the process. Additionally, the by-products from these chemical reagents can also be difficult to separate from the desired reaction products. Thus, there is much room for improvement to be made in simplifying Mitsunobu reactions and reducing the reagents necessary to carry them out by developing catalytic versions.

 

Project Title:

Polymer-supported phosphine and arsines as reagents, ligands and organic catalysts

Investigator(s):

Toy PH

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

(1) To synthesize and evaluate both soluble and insoluble polystyrene-supported phosphines and arsines for use as recyclable ligands in palladium catalyzed cross-coupling and platinum catalyzed alkyne boration reactions, and as nucleophilic reagents and catalysts. (2) To synthesize and evaluate chiral arsine oxides as catalysts for asymmetric alkene epoxidation reactions using hydrogen peroxide as the stoichiometric oxidant and then to immobilize these compounds onto water compatible matricies so that they can be recovered and reused.

 

Project Title:

The development of polymer-supported phoshites for use in nitrone reduction reactions

Investigator(s):

Toy PH

Department:

Chemistry

Source(s) of Funding:

France/Hong Kong Joint Research Scheme - Travel Grants

Start Date:

01/2007

 

Abstract:

1. To develop novel phosphites grafted on to polymers for use in the reduction of water soluble nitrones. 2. The use of such polymer-supported phosphites has several advantages in both research and industrial applications, such as: (1) simple recovery of reactants, and (2) separation of the reactants and products at the end of the reaction via simple filtration, without the performing phase extraction. 3. Possible use in diverse solvents.

 

Project Title:

Polyfunctional Supported Reagents and Catalysts for Organic Synthesis Applications

Investigator(s):

Toy PH

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

The objectives of this research proposal revolve around the development of new supported reagents and catalysts for organic synthesis that contain multiple functional groups that all actively participate in the reaction that the materials are designed for use in. In other words, we want to make the support a functional material, rather than a simple inert carrier.

 

List of Research Outputs

 

But Y.S. and Toy P.H., The Mitsunobu Reaction: Origin, Mechanism, Improvements, and Application , Chemistry -- An Asian Journal. 2007, 2: 1340-1355.

 

He R., Toy P.H. and Lam Y., Polymer-Supported Hantzsch 1,4-Dihydropyridine Ester: An Efficient Biomimetic Hydrogen Source , Advanced Synthesis and Catalysis . 2007, 350: 54-60.

 

Toy P.H., Lectureship Award, 2nd International Conference on Cutting-Edge Organic Chemistry, 2007.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Tsang KY



List of Research Outputs

 

Tsang K.Y., Preparation of Supported PT-Based Mixed Nanoparticles and their Catalytic Properties (PhD Thesis). 2007.

 

Researcher : Tse BL



List of Research Outputs

 

Tse B.L. and Chan W.T., Characterization of Bottom-viewed Inductively Coupled Plasma-atomic Emission Spectrometry (BV-ICP-AES), Abstract of Colloqium Spectroscopic um Internationale XXXV, Xiamen, China, September 23-27 . 2007.

 

Tse B.L., Development and Characterization of Bottom-viewed Inductively Coupled Plasma-Atomic Emission Spectrometry (MPhil Thesis) . 2007.

 

Researcher : Tse CW



List of Research Outputs

 

Tse C.W., Cheng K.W. and Chan W.K., Synthesis of Hyperbranched Polymers with Rhenium(I) Bis(Stilbazoylimino)Acephthalene Complexes at the Branching Units, Journal of Inorganic and Organometallic Polymers and Materials. Springer Science, 2007, 18: 59-68.

 

Researcher : Tse HS



List of Research Outputs

 

Tse H.S., Hu Y.H. and Sze K.H., Structure and Dynamics Studies of a Novel Ubiquitin Carboxyl Terminall Hydrolase by NMR Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-17.

 

Researcher : Tse MK



List of Research Outputs

 

Hui S.K., Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Funtional Study of a 9kDa a-heical Domain of BIR3-RING Linker Region in XIAP Protein by NMR Spectroscopy, Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E21.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Biophysical Characterization of a 13kDa Structural Domain in XAF1 Protein , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. A&E-20.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Structural and Functional Study of XIAP-Associated Factor 1 (XAF1) - Identification and Characterization of a 13kDa Structural Domain , 16th Triennial Conference for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. P1-17.

 

Tse M.K., Wong B.C.Y. and Sze K.H., Structural and function Stude of XIAP-Associated Flactor1 (SFA__P), International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007. A37.

 

Researcher : Vellaisamy ALR



Project Title:

DNA based molecular transistor devices

Investigator(s):

Vellaisamy ALR

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

DNA (Deoxyribo Nucleic Acid) the blueprint of life, has taken centre stage in biological research during the past few decades. DNA is the best nanowire in existence, and it self-assembles, self-replicates and can adopt various states of conformations. Of these, the most important property of DNA for a biomolecular engineer is its ability to self-assemble, which makes it possible to produce nanostructures with a precision that is not achievable with classical silicon-based technologies. Fink & Schonenberger were the first to measure current flow through DNA using a modified low-energy electron point-source microscope. Kasumov et al. reported that DNA also behaves like a proximity-induced superconductor, using λ-DNA of 16 µm to connect two rhenium carbon electrodes on a mica substrate. Aich and co-workers showed that DNA with zinc atoms incorporated between its bases also acts as a conductor. Molecular lithography has already been carried out using the RecA protein, which further increases the potential of using DNA for the chemical ‘growth’ of electronic parts. The electrical conduction through poly(dA)-poly(dT) and poly(dG)-poly(dC) DNA molecules has been reported and it was found that poly(dA)-poly(dT) behaves as an n-type semiconductor and poly(dG)-poly(dC) behaves as a p-type semiconductor. Here, for the first time we want to demonstrate a DNA ambipolar field effect transistor which can transport both electrons and holes, having genomic DNA as active material, with pronounced ambipolar current characteristics. This device gives a new insight on DNA based electronic devices for future applications.

 

Project Title:

Nano photonic devices based on polymer nano-rods

Investigator(s):

Vellaisamy ALR, Che CM, Chui SY

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

There is a growing interest in the development of new and inexpensive materials for photonic device applications. For high-performance and low-power photonic device applications, it is important to develop more flexible materials that can be structurally modified in order to accelerate the progress of research in nano-elecronics. In this proposal, the first deliverable is to achieve high performance low voltage nano photonic (light emitting field effect transistor) devices based on homoleptic copper (I) coordination polymer nano-rods which could be engineered to achieve high charge carrier transporting and electroluminescent properties. This proposal will integrate nano-rod device physics and materials chemistry by using copper (I) coordination polymers as advanced materials to build nano photonic devices. The objectives and key deliverables are: 1) Low voltage metal-organic polymer nano-rod light emitting device with FET (Field Effect Transistor) structure. 2) To design stable and inexpensive copper (I) polymer nano-rods possessing high charge carrier [electron (n-type) / hole (p-type) / ambipolar] transporting and electroluminescent properties by structural modifications.

 

List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Che C.M., Li C., Chui S.Y., Vellaisamy A.L.R. and Low K.H., Homoleptic Copper(I) Arylthiolates as a New Class of p-Type Charge Carriers: Structures and Charge Mobility Studies, Chemistry - A European Journal. Germany, 2008, 14: 2965-2975.

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Stallinga P., Vellaisamy A.L.R., Xu Z., Xiang H. and Che C.M., Metal-Insulator-Meta Transistors , Advanced Materials. 2008, 20: 2120-2124.

 

Vellaisamy A.L.R., Wong E.L.M., Ko B.C.B., Chao C.T., Yan S.C., Yan B., Wu J.C. and Che C.M., Ambipolar Charge Transport in DNA Molecules, Advanced Materials. Wiley InterScience, 2008, 20: 1258-1262.

 

Vellaisamy A.L.R., Bio-electronics Nanjing University, China, 2007.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Che C.M., Lai P.T., Zeng P.J., Niu F.F., Liu Y.W., Tang W.Q., He C.J. and Niu H.B., Star-configured Carbazole as an Efficient Near-ultraviolet Emitter and Hole-transporting Material for Organic Light-emitting Devices , Applied Physics Letters. 2008, 92: 073305-1 to 073305-3.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Researcher : Wang B



List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Researcher : Wang B



List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Researcher : Wang F



List of Research Outputs

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Wang F., Yam C.Y., Chen G., Wang X.J. and Fan K.N., Linear Scaling Time-dependent Density-functional Thight-binding Method for Absorption Spectra of Large Systems , Physical Review B. 2007, 76: 045114-1 - 045114-6.

 

Researcher : Wang H



List of Research Outputs

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Chan G.K.Y., Ren J., Wang H. and Ding J., Strategies of Nanostructing Fuel Cell Electrodes , Proceedings of 2007 First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Wang H., Structural and Functional Studies of the Neuronal Growth Inhibitory Factory, Human Metallothionein-3 (PhD Thesis) . 2008.

 

Wang H., Li H., Cai B., Huang Z. and Sun H., The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein, Journal of Biological Inorganic Chemistry. 2008, 13: 411-419.

 

Researcher : Wang H



List of Research Outputs

 

Chan G.K.Y., Ren J., Ting S.W., Ding J. and Wang H., Methanol Oxidation on Platinum Nanoparticles Supported on Well Defined Mesoporous Carbons , Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, . 2007.

 

Chan G.K.Y., Ren J., Wang H. and Ding J., Strategies of Nanostructing Fuel Cell Electrodes , Proceedings of 2007 First International Workshop on Nanotechnology and Application (IWNA), Vung Tau, Vietnam, November 15-17, 2007.

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Wang H., Structural and Functional Studies of the Neuronal Growth Inhibitory Factory, Human Metallothionein-3 (PhD Thesis) . 2008.

 

Wang H., Li H., Cai B., Huang Z. and Sun H., The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein, Journal of Biological Inorganic Chemistry. 2008, 13: 411-419.

 

Researcher : Wang Y



List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Wang Y., Che C.M., Chiu J. and He Q.Y., Dioscin (Saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: A proteomic-based study, Journal of Proteome Research. 2007, 6: 4703-4710.

 

Wang Y., Chiu J. and He Q.Y., Isolation of cytoplasmatic proteins from cultured cells for two-dimensional gel electrophoresis, In: A. Posch, Methods in Molecular Biology. U. S. A., Human Press, 2008, 425: 101-112.

 

Wang Y., He Q.Y., Che C.M., Tsao G.S.W., Sun R.W.Y. and Chiu J., Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways, Biochemical Pharmacology. 2008, 75: 1282-1291.

 

Researcher : Wang Y



List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Wang Y., Che C.M., Chiu J. and He Q.Y., Dioscin (Saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: A proteomic-based study, Journal of Proteome Research. 2007, 6: 4703-4710.

 

Wang Y., Chiu J. and He Q.Y., Isolation of cytoplasmatic proteins from cultured cells for two-dimensional gel electrophoresis, In: A. Posch, Methods in Molecular Biology. U. S. A., Human Press, 2008, 425: 101-112.

 

Wang Y., He Q.Y., Che C.M., Tsao G.S.W., Sun R.W.Y. and Chiu J., Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways, Biochemical Pharmacology. 2008, 75: 1282-1291.

 

Researcher : Wang Y



List of Research Outputs

 

Chan G.K.Y., Wang Y., Wang B., Cui Y. and Li X.Y., Efficient Electrochemical Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9,. 2007.

 

Chan G.K.Y., Chan C.Y., Cui Y., Wang Y., Wang B., Li X.Y., Lin W. and Christensen P.A., Efficient Electrolytic Generation of Ozone from Water with a Novel Electrode Material, Proceedings of 2007 World Congress on Ozone and Ultraviolet Technologies (IUVA), Los Angeles, California, U.S.A., August 27-29, . 2007.

 

Chan G.K.Y., Wang Y., Wang B. and Cui Y., Methanol Oxidation on Platinum Nanoparticles Supports on Well Defined Mesoporous Carbons , Keynote Lecture at 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007. 2007.

 

Wang Y., Che C.M., Chiu J. and He Q.Y., Dioscin (Saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: A proteomic-based study, Journal of Proteome Research. 2007, 6: 4703-4710.

 

Wang Y., Chiu J. and He Q.Y., Isolation of cytoplasmatic proteins from cultured cells for two-dimensional gel electrophoresis, In: A. Posch, Methods in Molecular Biology. U. S. A., Human Press, 2008, 425: 101-112.

 

Wang Y., He Q.Y., Che C.M., Tsao G.S.W., Sun R.W.Y. and Chiu J., Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways, Biochemical Pharmacology. 2008, 75: 1282-1291.

 

Researcher : Watt RM



Project Title:

New Chemical Proteomics Methods For Selective Protein Capture And Identification

Investigator(s):

Watt RM, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Chemical proteomics (sometimes referred to as chemistry-based functional proteomics) is an extremely new and exciting area within the chemical biology field. It is broadly defined as being the integration of protein biochemistry and organic chemistry to study protein function on a genome wide scale. The main aims of chemical proteomics are to directly identify, quantify and characterize the ultimate products of genes, i.e. proteins: the bio-molecules that are the main effectors of activity within the cell. This is essential for a true and intimate understanding of cellular biology and function - one that cannot be gleamed solely from genetic or transcription-based analyses.Thus far, most of the research in chemical proteomics has centered on the design and synthesis of small chemical molecules that covalently label target proteins, enabling them to be subsequently identified and/or purified. These chemical probes are designed in such a way as to selectively modify certain classes of proteins, based upon mechanistic similarities (e.g. a shared active-site topography) or due to the nature or arrangement of their component amino acid residues. Aspects of this technology are related to two approaches commonly used in medicinal chemistry, for the identification of possible protein targets of drugs or other bio-molecules within the cell. In the first of these approaches, the drug (or an analogue of it) is linked to a resin or bead, which is used to capture interacting protein species from a cell-free extract. These are subsequently identified by mass spectrometry, protein sequencing or antibody-based methods. In the second approach, a radio- or fluorescently- labeled analogue of the drug or enzyme substrate is used to covalently modify the target protein, which is subsequently purified and identified.Thomas Kodadek (University of Texas Southwest Medical Center), Benjamin Cravatt (Scripps Institute, Skaggs Institute for Chemical Biology) and Matthew Bogyo (Celera Genomics and Stanford University) have conducted some innovative research in this field, developing a number of small chemical affinity probes to target classes of proteins that include proteases, hydrolases and phosphatases. They have outlined two main approaches: a) activity-based probes, and b) affinity-based probes. Activity-based chemical probes may be thought of as being analogous to mechanism-based or suicide inhibitors, in that they irreversibly label proteins directly as a result of their catalytic activities. Affinity-based probes may be thought of as being more general protein labeling agents, not directly linked to protein activity. These reagents do not necessarily target active sites residues, but still bind tightly to specific families of proteins, covalently modifying them. In addition, there are non-specific protein labeling reagents that chemically modify a broad range of proteins, usually targeting specific residues e.g. cysteine thiols or lysine amines.In this proposal, I will take a slightly different approach. I will synthesize a novel set of chemical affinity probes to target families of essential and ubiquitous metabolic and biosynthetic proteins/enzymes. The chemical affinity probes will contain a 'reactive' moiety that will be the main determinant for the types of proteins targeted, as well as a component that will enable subsequent affinity-based protein purification or localization on 2D gels by fluorimetry. Two main types of affinity probes will be synthesized: Highly selective probes targeting functionally-related protein families Less functionally-selective probes, targeting a broader range of proteinsStructurally simple reactive homologues of intermediates in common biosynthetic pathways will be used as components of the probes with a more general selectivity. The rationale behind this being that many of these intermediates are shared between different pathways (which are generally highly conserved between organisms), and they form the structural basis of numerous bioactive compounds. Choosing these types of compound maximizes the likelihood of finding chemical affinity probes of broad applicability. These chemical molecules will be designed to bind irreversibly to families of proteins within cells, in a cell or tissue extract (e.g. mouse liver extract, bacterial cell lysate, etc.) or in a biological fluid sample (e.g. plasma, plant sap, etc.).I will focus on (P450-type) oxidases; intermediates of fatty-acid and polyketide biosynthesis; amino acid and small-molecule biosynthesis and metabolism. Established mechanism-based enzyme inactivators will be used along with other simple drug and biosynthetic compound analogues. Synthetic strategies will be kept deliberately straightforward, maximizing the time spent on optimizing the protein labeling chemistry and experimental conditions, etc. I will consciously use compounds that will be relatively non-specific in nature to maximize the potential for serendipitous discovery.

 

Project Title:

The identification and characterization of new bacterial protein targets for inhibition - determining their potential for antibiotic development

Investigator(s):

Watt RM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

08/2006

 

Abstract:

As a newly appointed RAP within the chemistry department, I would like to establish a new area of research focused on the study of essential bacterial proteins, with a view to discovering new antibiotic compounds, and new targets for antibacterial chemotherapy. There are two main research objectives in this Seed Funding proposal: 1) To biochemically characterize several putatively essential bacterial proteins, and identify at least two that will be amenable to subsequent high throughput inhibitor screening 2) To purify the ‘native’ complexes formed by a number of these essential proteins within their natural host using a newly developed ‘tandem affinity’ (TAP) tag procedure, for subsequent analysis by mass spectrometry After reviewing the literature, and performing various bioinformatic analyses of sequenced bacterial genomes, a number of candidate proteins have been identified for detailed investigation (see below). These proteins are all essential or putatively essential, and fall within three specific functional categories. I have focused on proteins from a variety of bacterial species that are either model organisms, or are medically important pathogens. This will enable the functions of different family members (homologues) to be compared and contrasted, hopefully allowing some important general conclusions to be drawn after the completion of the experiments. The 3 areas I will focus on are: Polyphosphate and pyrophosphate degradation A small family of GTPases of poorly defined or unknown function The last two steps of the methylerythriyol phosphate (MEP) biosynthetic pathway All organisms have at least one inorganic pyrophosphatase, which catalyzes the breakdown of pyrophosphate (diphosphate) to two phosphate (orthophosphate) molecules. The very high free energy for this process is the driving force for many thermodynamically unfavourable biochemical reactions. Consequently, the activity of this enzyme activity is essential in all known organisms. Certain bacteria appear to have two types of pyrophosphatase: one that preferentially uses magnesium as a cofactor (type A, Ppa), and another that prefers manganese or cobalt (Family II, or type C, PpaC). Mutagenesis studies in a number of organisms have shown that both genes are essential, which suggests that the two proteins have non-overlapping or non-complementary functions. The PpaC family of pyrophosphatases may also play a role in the degradation of polyphosphate (long chain phosphate), which is an enigmatic intracellular molecule, with a poorly defined function. Polyphosphate is thought to be involved in metal transport, metal sequestration and the stress response, amongst many other processes. I have identified a putative type C pyrophosphatase in Mycobacterium tuberculosis (the causative agent of tuberculosis), as well as another gene that may encode an additional exopolyphosphatase (which degrades polyphosphate) or possibly even a guanosine tetraphosphatase (ppGpp) hydrolase (a protein that degrades an important nucleotide-phosphate signaling molecule). Consequently, I will clone, express and characterize the biochemical and biophysical properties of these two proteins, to investigate this hypothesis. Furthermore, as both genes are essential, I will determine whether it will be possible to develop biochemical assays that will be suitable for use in high throughput inhibition studies (with a commercial library of compounds, to be performed at a later date). Finding specific inhibitors for these two classes of bacterial enzymes is especially attractive, as there are no homologues in higher organisms. Within bacteria, there is a family of essential and highly conserved bacterial GTPase proteins, whose activities are currently poorly understood. The family comprises the following genes: era (bex), engA (der, yfgK), engB (yihA), engD (obg, yhcf), trmE (thdF), hflX, ftsY, obgE (ctgA, yhbZ), and ffh. However, there may be redundancy or some overlapping of activities within this family, as some bacteria do not appear to have all of them (they generally have between 5 to 8 members). I have already cloned a number of these genes from Pseudomonas aeruginosa and Staphylococcus aureus (opportunistic pathogens), vibrio cholerae (the causative agent of cholera) and E. coli (a model bacterium, that is sometimes pathogenic). For this proposal, I plan to investigate their NTPase (nucleotide and deoxynucleotide triphosphatase) activities, specifically regarding its stimulation upon RNA or DNA binding. I will also try to identify interacting protein species within the cell, using a TAP tag. If the NTPase activity is high enough, then it may be possible to design assays amenable to high throughput inhibitor screening. Until recently, it was thought that all organisms synthesized isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), key metabolites in isoprenoid biosynthesis, via the same route: the mevalonate pathway. However, less than 10 years ago, several researchers showed that in most bacteria, some parasites, and in the chloroplasts of plants, that this was not the case. Subsequently the 7-step methylerythritol phosphate (MEP) pathway was gradually elucidated. As the synthesis of IPP and DMAPP is essential in all organisms, this makes the MEP pathway an excellent target for the development of selective antibiotic, anti-parasitic or herbicidal agents. The first 5 steps of the MEP pathway are well understood, but the mechanisms of the last two steps, catalyzed by the GcpE and LytB proteins respectively, remain to be fully established. Both of these enzymes require auxiliary redox proteins for activity. Working in collaboration with a research team in France, I plan to identify these redox proteins in E.coli, Pseudomonas aeruginosa and in the model plant Arabidopsis thaliana. I plan to use my recently developed TAP tag to do this. The French collaborators will work on other aspects of the chemical processes. The three areas of research described above will all utilize similar methodology, reagents and equipment, and are thus partially overlapping. I will focus most of my initial efforts on characterizing the two putative mycobacterial phosphatases, but also envisage fairly rapid progress to be made in the two other areas.

 

Project Title:

Isoprenoid biosynthesis via the methylerythritoal phosphate (MEP) pathway: proteomic analysis and identification of targets for inhibition

Investigator(s):

Watt RM

Department:

Chemistry

Source(s) of Funding:

France/Hong Kong Joint Research Scheme - Travel Grants

Start Date:

01/2007

 

Abstract:

1. Identify the protein complexes (specifically, the accessory redox proteins) that are involved in the final two steps of the essential methylerythritol phosphate (MEP) biosynthetic pathway in a number of plant and medically-important bacterial species. 2. Compare and contrast experimental results with literature data. Thoroughly investigate any potential differences that may exist in the nature of the putative accessary protein complexes used in the various plant and bacterial species (i.e. are there different mechanisms for protein reduction/oxidation?). 3.Evaluate overall project findings, and formulate strategies for future research directions. Identify candidate proteins as possible targets for inhibition, with a view to the development of potential biocide (antibacterial, herbicide) agents.

 

List of Research Outputs

 

Yang N., Tanner J.A., Zheng B., Watt R.M., He M.L., Lu L., Jiang J., Shum K.T., Lin Y., Wong K.L., Lin M.C., Kung H.F., Sun H. and Huang J., Bismuth complexes inhibit the SARS coronavirus, Angewandte Chemie International Edition. 2007, 46: 6464-6468.

 

Researcher : Wong CL



List of Research Outputs

 

Xu S., Wong C.L., Tong H.Y., Chung S.S.M. and Ko C.B., Phosphorylation By Casein Kinase 1 Regulates Tonicity-induced Osmotic Reponse Element-binding Protein/tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking, Journal Of Biological Chemistry. 2008, 283: 17624-34.

 

Researcher : Wong ELM



List of Research Outputs

 

Sun R.W.Y., Ma D.L., Wong E.L.M. and Che C.M., Some Uses of Transition Metal Complexes as Anti-cancer and Anti-HIV Agents , Dalton Transactions. 2008, 4884-4892.

 

Tong S.M., Wong E.L.M. and Che C.M., Density Functional Theory Study of trans-Dioxo Complexes of Iron, Ruthenium, and Osmium with Saturated Amine Ligands, trans-[M(O)2(NH3)2(NMeH2)2]2+ (M=Fe, Ru, Os), and Detection of [Fe(qpy)(O)2]n+ (n=1, 2) by High-Resolution ESI Mass Spectrometry, Chemistry - A European Journal. 2008, 14: 5495-5506.

 

Vellaisamy A.L.R., Wong E.L.M., Ko B.C.B., Chao C.T., Yan S.C., Yan B., Wu J.C. and Che C.M., Ambipolar Charge Transport in DNA Molecules, Advanced Materials. Wiley InterScience, 2008, 20: 1258-1262.

 

Researcher : Wong JKY



Project Title:

Luminescent benzylic amide macrocycle-based metal complexes with potential sensing capabilities

Investigator(s):

Wong JKY, Yam VWW

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To synthesise macrocycle-containing metal complexes; to add guest and test the benzylic amide macrocycle-based metal complexes as luminescent sensors.

 

 

Researcher : Wong KL



List of Research Outputs

 

Fan H.H., Wu K.S., Wang H.Z., Tian Y.P., Law G.L., Wong K.L. and Wong W.T., Effective Multi-photon Absorption Properties in Solutions of Pyridinium Salt Lasing Dyes , Chemical Physics Letters. 2007, 449: 77-81.

 

Researcher : Wong MC



Project Title:

Design and Synthesis of Luminescent Organoplatinum(II) Terpyridyl Complexes with Donor and/or Acceptor Pendants

Investigator(s):

Wong MC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2006

 

Abstract:

The study of transition metal σ-bonded alkynyl complexes has grown rapidly due to their technological potentials that may differ from those of conventional organic counterparts. Although there are numerous reports on the synthesis, structure and bonding, and studies of electronic communication between metal centres through the π-conjugated oligo-alkynyl bridges by electrochemical techniques, relatively less attention was focused on the exploration and exploitation of their spectroscopic properties, such as their electronic absorption and luminescence behaviours. By introduction of the linear alkynyl group with the unique properties of having good σ-donor, π-acceptor and π-donor abilities into luminescent transition metal complexes, fine-tuning and perturbation of emission behaviours, in the sense of energy, emission intensity and lifetime could be envisaged. There has been a growing interest in the study of photoinduced charge separation and photoinduced electron and/or energy transfer processes in a multicomponent system, [A]-[C]-[D], consisting of a photoactive centre (C), a donor (D) and an acceptor (A), due to their potential applications in molecular electronics, solar cells (artificial photosynthesis) and luminescence chemosensors. In such system, the complex usually displays an intense absorption band attributed to the charge transfer (CT) transition. Moreover, a charge separated species, [A-]-[C]-[D+], could be generated upon absorption of a photon followed by a photoinduced electron transfer process. The synthesis of these molecules for photoinduced charge separation is often challenging because of the multistep procedures that are involved in their construction and purification. The use of organic molecules as fluorescent chemosensors have also been well-developed, however, the advantages over them, such as long luminescence lifetime, lower excitation wavelength, low interference level and higher stability, have led to a great interest in the utilization of transition metal complexes as luminescence chemosensor. Apart from ruthenium(II) and rhenium(I) polypyridyl complexes with triplet dπ(M)→π*(polypyridyl) metal-to-ligand charge transfer (MLCT) excited states which show rich photophysical behaviour, the platinum(II) terpyridyl complexes, [Pt(trpy)L]n+ (n = 1 or 2; trpy = terpyridyl ligand; L = anionic or neutral ligand), have also been extensively studied and shown to exhibit rich luminescence attributed to triplet MLCT excited state. In order to improve the luminescence behaviours, such as the enhancement of luminescence quantum yields and elongation of excited state lifetimes, destabilization of the triplet d-d excited state and/or stabilization of the triplet MLCT state are anticipated to serve this purpose. The first series of platinum(II) terpyridyl alkynyl complexes, [Pt(trpy)(C≡CR)]X, have been reported by Yam et al through the incorporation of alkynyl moieties into the platinum(II) terpyridyl system. Unlike the chloro- counterpart, [Pt(trpy)Cl]X, these complexes were found to exhibit luminescence even in the fluid solution at room temperature, demonstrating the importance of introducing the strongly σ-donating alkynyl in enriching their luminescence properties. Another strategy for the improvement of the luminescence properties of platinum(II) terpyridyl systems is to modify the substituents on the terpyridine to bring about: (i) the stabilization of the luminescent triplet MLCT state or (ii) incorporation of intra-ligand character into the excited state. By the combination of the substituent effects on the terpyridine ligand and the incorporation of alkynyl moiety into platinum(II) terpyridyl system, it is envisaged that modification of the terpyridyl and alkynyl moiety would perturb the triplet MLCT excited state. In view of this, togethr with their high stability and straightforward synthetic accessibility, platinum(II) terpyridyl alkynyl complexes would be an ideal candidate for the construction of multicomponent system, [A]-[C]-[D], for the study of the charge separation and the platinum(II) metal centre can act as the component [C] mediating the electron and/or energy transfer processses, while the other components [A] and [D] could be the terpyridyl or alkynyl ligands. Thus an objective of this project is to design and synthesize different terpyridyl chelator and alkynyl ligands with various electron-donating/withdrawing substituents for the modification of their π- and π*-energy levels, and to coordinate them to the platinum(II) metal centre to form the corresponding mononuclear platinum(II) terpyridyl alkynyl complexes. Their electronic absorption, luminescence as well as electrochemical properties would be studied. By a suitable choice of various donor and acceptor groups on the terpyridyl and alkynyl ligands of such platinum(II) complexes, such as a donor group on the alkynyl ligand and an acceptor group on the terpyridyl chelator, charge transfer from such an donor-acceptor system as well as electron and/or energy transfer processes with the involvment of the platinum(II) metal centre and charge separation are anticipated. Since the electron richness of the amino group is readily varied upon protonation or reaction of other reactive species, the electronic absorption as well as luminescence behaviour of such donor-acceptor system would be perturbed. In light of this concept, the proposed mononuclear platinum(II) terpyridyl alkynyl complexes with an amino donor group could also be utilized as luminescence chemosensors.

 

Project Title:

Photoluminescence and Electroluminescence Properties of Alkynyl Rhenium(I) Diimine Complexes

Investigator(s):

Wong MC

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

The first report on the photophysical properties of rhenium(I) tricarbonyl diimine complex, [Re(CO)3(phen)Cl], was described by Wrighton et al. and the luminescent metal-to-ligand charge-transfer (MLCT) excited state assignment was proposed. Later on, numerous studies on the luminescence properties of related rhenium(I) tricarbonyl diimine complexes, including derivatives of the chlororhenium(I) tricarbonyl diimine complexes such as those obtained by the replacement of the chloro ligand with pyridine, phosphine, nitrile or isonitrile ligands, have been reported. It is anticipated that incorporation of strong σ-donating alkynyl ligands would raise the energy of the d-d states of the rhenium(I) centre and thereby improve the population of the MLCT state. The synthesis and photophysical properties of luminescent alkynyl rhenium(I) tricarbonyl diimine complexes, [Re(CO)3(diimine)(C≡CR)], were first reported by Yam et al. in the 1990's.. The origin of such luminescence has been ascribed to a triplet MLCT [dπ(Re) → π*(N-N)] excited state, probably with some mixing of a [π(C≡C) → π*(N-N)] ligand to-ligand charge transfer (LLCT) character taking into consideration the relatively high-lying filled π(C≡C) orbital energy. The luminescence energies have been found to be dependent on the nature of both the diimine and the alkynyl ligands.The huge demand of flat panel displays in the commercial market has attracted considerable research in the development of organic light-emitting devices (OLEDs), which is one of the most important candidates of potential flat panel displays for commercialization due to the advantages of robustness, ease of fabrication and color tuning, wide viewing angle, high brightness and contrast ratios, low turn-on voltages and low energy consumption. Efficient electroluminescence (EL) from organic films at low voltages was first reported in 1987. Since then, a variety of EL materials have been synthesised, and various techniques for device fabrication have been optimized. There have been significant improvements in OLED efficiencies by using phosphorescent materials to generate light emission from both singlet and triplet excitons, particularly for small molecule OLEDs, in which triplet excitons are efficiently harvested through the incorporation of heavy metal centres that would increase spin-orbit coupling and hence intersystem crossing into the triplet state. Therefore, employment of transition metal complexes as the emissive layer or as phosphorescent dopants in OLEDs has become one of the important subjects in recent years in order to demonstrate excellent electroluminescence properties and potential advantages of achieving a maximum internal quantum efficiency of 100%. Despite recent interest in the exploration of electrophosphorescent materials, in particular metal complexes with heavy metal centers, most of the works are focused on those of iridium(III), platinum(II) and ruthenium(II) with other metal centers relatively less extensively explored. Although the electroluminescence behaviours of a few rhenium(I) tricarbonyl diimine complexes have been explored recently, the related studies of luminescent alkynyl rhenium(I) system are totally unexplored. On the other hand, many carbazole/amino derivatives are well known to transport predominantly positive charge carriers as hole-transporting (HT) compounds, while aromatic oxadiazole is known to be a good candidate as electron-transport (ET) or hole-blocking material. Integration of HT and ET components into such luminescent rhenium(I) tricarbonyl diimine system is anticipated to give rise to systems with more efficient charge transport and improved charge balance between the holes and electrons in the electroluminescence process. Introduction of strong σ-donating ligand into rhenium(I) tricarbonyl diimine compounds is envisaged not only to enhance the luminescence properties but also to provide a versatile synthetic methodology for the construction of multicomponent phosphorescence materials. In view of the MLCT/LLCT luminescence origin of the alkynyl rhenium(I) tricarbonyl diimine system, the incorporation of ET and HT components into the diimine and alkynyl moieties, respectively, would be a judicious choice to enhance the electroluminescence behaviours through the improvement of charge transport and balance. Moreover, fabrication of single layer OLEDs is anticipated by the ultilization of such multicomponent rhenium(I) complexes functioning as the emissive, HT and ET materials at the same time. Thus the objectives of this project are: (1) to design and synthesize different diimine and alkynyl ligands tethered with aromatic oxadiazole and carbazole/amino substituents, respectively, for the ET and HT functions, and to coordinate them into the rhenium(I) metal centre to form the corresponding alkynyl rhenium(I) tricarbonyl diimine complexes; and (2) to study in addition to their electronic absorption and photoluminescence properties, the corresponding electroluminescence behaviours, such as luminance, turn-on voltage, luminous power efficiency and external quantum efficiency, in order to correlate with the variation of diimine and alkynyl ligands.

 

List of Research Outputs

 

Moussa J., Wong M.C., Chamoreau L.M., Amouri H. and Yam V.W.W., Luminescent 1D Chain of Platinum(II) Terpyridyl Units with p-Dithiobenzoquinone Organometallic Linker: Self-aggregation Imparted from Pt...Pt/p-p Interactions , Dalton Transactions. 2007, 3526-3530.

 

Sun Q.F., Wong M.C., Liu L.X., Huang H.P., Yu X.Y., Yam V.W.W., Yi Y.Z., Pan Y.J. and Yu K.C., Self-assembly, Structures, and Photophysical Properties of 4,4'-Bipyrazolate-linked Metallo-Macrocycles with Dimetal Clips, Inorganic Chemistry. 2008, 47: 2142-2154.

 

Tam Y.Y., Lam S.W.H., Wong M.C., Zhu N. and Yam V.W.W., Luminescent Alkynylplatinum(II) Complexes of 2,6-Bis (N-alkylbenzimidazol-2'-yl) Pyridine-Type Ligands with Ready Tunability of the Nature of the Emissive States by Solvent and Electronic Property Modulation , Chemistry - A European Journal. 2008, 14: 4562-4576.

 

Yam V.W.W. and Wong M.C., From Simple Molecules to Molecular Functional Materials and Nanoscience , In: Zikang Tang and Ping Sheng (eds.), Nanoscale Phenomena: Basic Science to Device Applications . Springer, 2007, Vol. 2 (Chapter 19): 217-234.

 

Yu C., Chan H.Y., Wong M.C. and Yam V.W.W., Polyelectrolyte-induced Self-assembly of Positively Charged Alkynylplatinum(II) - Terpyridyl Complexes in Aqueous Media , Chemistry - A European Journal. 2008, 4577-4584.

 

Researcher : Wong MK



Project Title:

Selective Ligation of Cysteine-Containing Proteins by Alkynes in Aqueous Medium

Investigator(s):

Wong MK, Che CM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

Selective ligation of cysteine is one of the most important strategies in protein bioconjugation and is of significance in construction of small molecule-protein bioconjugates, positional proteomics studies and fabrication of peptide and protein microarrays. Cysteine is a strong nucleophile in proteins and is commonly used as the site for chemical ligation. Owing to its high reactivity, methods have been deveploped for artificial incorporation of cysteine into defined positions of proteins for conjugation. Traditionally, cysteine can be modifed via nucleophilic additions (e.g. using N-alkylmaleimides) and displacement reactions (e.g. using haloalkyl compounds) with the cysteine thiolate anion as the nucleophile. However, it remains a challenge to selectively modify the cysteine sulfhydryl group of proteins with other nucleophilic side chain residues of histidine, methionine, lysine, and tyrosine remaining intact especially at high pH. Recently, we have found that electron-deficient alkynes are efficient electrophiles for selective modification of cysteine sulfhydryl groups via nucleophilic addition in high yields in aqueous medium at room temperature. In addition, the electron-deficient alkynes are effective for site-selective modification of unprotected peptides in aqueous medium. LC-MS/MS analysis confirmed that the cysteine sulfhydryl groups of peptides STSSSCNLSK and AYEMWCFHQK were exclusively modified with the side chains of histidine, methionine, lysine, and tyrosine remaining intact. To the best of our knowledge, the present method is the first example using alkynes for selective ligation of native peptides. With the promising findings, we plan to (1) expand the scope of the alkyne-cysteine conjugation reaction in selective modification of peptides and proteins, (2) design and synthesize alkyne-linked fluorescent probes for live cell imaging, and (3) apply the alkyne-based molecular probes for proteomic studies of caspases in apoptotic cells.

 

List of Research Outputs

 

Liu Y., Xiao W., Wong M.K. and Che C.M., Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin , Organic Letters. 2007, 9: 4107-4110.

 

Lo K.Y., Wong M.K. and Che C.M., Gold-Catalyzed Highly Enantioselective Synthesis of Axially Chira Alenes , Organic Letters. 2008, 10: 517-519.

 

Researcher : Wong MY



List of Research Outputs

 

Ye J., Pang H.F., Wong M.Y., Leung W.H. and Cheung A.S.C., Laser Spectroscopy of Iridium Monoboride , The Journal of Chemical Phyics. 2008, 128: 154321-1 - 154321-6.

 

Researcher : Wong SY



List of Research Outputs

 

Wong S.Y., Gu Y., Sze-To L. and Wong W.T., An Open-channel Architecture Assembly from the [Os3(CO)8{m-h3-ON=CPh(NC5H4)}2] Cluster , Crystengcomm. 2008, 10: 29-33.

 

Researcher : Wong WT



Project Title:

Coordination polymers of transition metals and lanthanide metals

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To establish new synthetic routes to metal coordination polymers; to investigate the 3-D structures of these new metal containing polymers; to study the small molecule inclusion properties of these materials.

 

Project Title:

Relaxometric and stability studies of binuclear gadolinium complexes of cyclic polyaminocarboxylate ligands

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Central Allocation Vote - General Award

Start Date:

03/2004

 

Abstract:

This project aims at developing new binuclear gadolinium (Gd) complexes with high water proton relaxivity, good thermodynamic stability, and high in vivo specificity.

 

Project Title:

Gadolinium Complexes of Functionalised Tetraazacyclodedecane Ligands: Magnetic Resonance Imaging Contrast agents

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To design and prepare new gadolinium (Gd) complexes containing functionalised tetraazacyclodedecane (cyclen) ligands; to study their structures in both the solid-state and in solution; to investigate the relaxivity and thermodynamic stability of these new Gd complexes in water; to carry out in vivo magnetic resonance imaging using these Gd complexes on rats; to evaluate the potential applications of these new complexes as contrast enhancing agents in magnetic resonance imaging (MRI).

 

Project Title:

Synthesis and properties of lanthanide polyamido complexes

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To establish new synthetic methods to lanthanide complexes containing amido ligands; to characterize these new compounds by spectroscopic and crystallographic methods; to investigate the chemical and photochemical properties of these new materials.

 

Project Title:

Novel gadolinium bis(amide)tricarboxylate complexes as contrast agents in hepatobiliary magnetic resonance imaging

Investigator(s):

Wong WT, Khong PL, Botta M

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2005

 

Abstract:

To design and prepare new types of gadolinium (Gd) complexes containing functionalised bis(amide)tricarboxylate ligands; to investigate the relaxivity and thermodynamic stability of these new Gd complexes in water; to study the toxicity of these metal complexes; to evaluate the potential of using these Gd complexes as liver specific contrast agents in magnetic resonance imaging (MRI).

 

Project Title:

Lanthanide-based Luminescent Materials

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/2006

 

Abstract:

Objectives: 1. Design and synthesise new lanthanide complexes containing polyamide ligands 2. Study the structural properties of these new complexes in both solution and the solid-state 3. Study their luminescent properties such as photo-upconversion

 

Project Title:

Lanthanide polyamide complexes for upconversion materials

Investigator(s):

Wong WT

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

There has been significant interest in the nonlinear luminescence from organic-lanthanide complexes owing to their potential applications in three-dimensional fluorescence imaging, optical data storage, lithographic microfabrication, and laser device fabrication. Multiphoton (e.g. indirect three-photon) processes allow the excitation of fluorophores in a lower energy spectral region - this is useful for optical communications (such as three-dimensional data storage) and is particularly important for imaging and therapy as longer wavelength radiation is less harmful to the body's tissues and cells and allows efficient penetration with less damage. Multiphoton excitation allows molecules that typically absorb in the ultraviolet region to be excited with red or near-infrared light. The photoluminescence processes from organic-lanthanide complexes are usually induced by an organic chromophoric ligand that absorbs light and transfers this excitation energy to the lanthanide ion. A number of complexes of lanthanide (Ln) ions with organic chromophores have been synthesized and their two-photon absorption induced f-f photophysical properties investigated. Complexes of EuIII, TbIII, DyIII, ErIII, NdIII, SmIII, and YbIII ions with fluorescent chelators, and complexes of EuIII and TbIII ions with nucleic acids and proteins have been reported. Until now, only a few multi-photon absorption and nonlinear processes have been observed owing to the limitations of experimental measurements, but with recent advances in technology experimentation has coalesced with theory to allow direct three-photon excitation. Stimulated emission following direct three-photon excitation has only been observed for one organic chromophore, and reports of three-photon up-conversion processes from organic-lanthanide complexes are very scarce. In this project, we will develop some synthetic routes to lanthanide complexes that show a direct multi-photon absorption induced f-f emission and nonlinear process in organic-lanthanide complexes (Ln=Eu, Gd and Tb) upon excitation at 650 nm to 1600 nm (Infra-red region). Objectives: 1. Synthesis of lanthanide complexes containing polyamide ligands 2. Study the luminescent behavior of these new compounds 3. Investigate the non-linear optical behavior of these new compounds in the solid state 4. Examine their thermal and chemical stability

 

List of Research Outputs

 

Bindya S., Wong W.T., Ashok M.A., Yathirajan H.S. and Rathore R.S., Amitriptylinium Picrate: Conformational Disorder , Acta Crystallographica Section C . 2007, 63: O546-O548.

 

Chan K.W.Y. and Wong W.T., Small Molecular Gadolinium(III) Complexes as MRI Contrast Agents for Diagnostic Imaging , Coordination Chemistry Reviews . 2007, 251: 2428-2451.

 

Fan H.H., Wu K.S., Wang H.Z., Tian Y.P., Law G.L., Wong K.L. and Wong W.T., Effective Multi-photon Absorption Properties in Solutions of Pyridinium Salt Lasing Dyes , Chemical Physics Letters. 2007, 449: 77-81.

 

Lau J.P.K., Gu Y. and Wong W.T., High-yield Synthesis of a New layered High-nuclearity Carbonyl Osmium-rhodium Cluster Complex -- Synthesis Structural Characterization, and Electrochemistry of [PPN][Os9Rh3(m-CO)2(CO)26], European Journal of Inorganic Chemistry. 2007, 3011-3014.

 

Law G.L., Wong K.L., Man C.W.Y., Wong W.T., Tsao G.S.W., Lam M.H.W. and LAM P.K.S., Emissive Terbium Probe for Multiphoton in Vitro Cell Imaging , Journal of the American Chemical Society. 2008, 130: 3714-3715.

 

Law G.L., Wong K.L., Yang Y.Y., Yi Q.Y., Jia G.H., Wong W.T. and Tanner P.A., Structural Characterization of Shielded Isomeric Europium Complexes with Metal-metal Contact , Inorganic Chemistry. 2007, 46: 9754-9759.

 

Law G.L., Wong K.L., Lau K.K., Tam H.L., Cheah K.W. and Wong W.T., Synthesis, Crystal Structures, and Photophysical Properties of Lanthanide Complexes Containing Pyrrole-derivatized Carboxylate Ligands , European Journal of Inorganic Chemistry. 2007, 34: 5419-5425.

 

Law G.L., Kwok W.M., Wong W.T., Wong K.L. and Tanner P.A., Terbium Luminescence Sensitized Through Three-Photon Excitation in a Self-assembled Unlinked Antenna , Journal of Physical Chemistry B. 2007, 111: 10858-10861.

 

Lee Y.B. and Wong W.T., Iridium Insertion to Triosmium Cluster Containing Unsaturated Os-Os Bonds , Journal of Cluster Science. 2008, 19: 133-145.

 

Lee Y.B. and Wong W.T., New Triosmium-iridium Clusters: Synthesis and Molecular Structure of [Os3Ir2(Cp*)2(m-OH) (m-CO)2(CO)8Cl](1), [Os3IrCp*(m-OH)(CO)10Cl](2), [Os3IrCp*(m-H)(m-Cl)(h3, m3-C5H2N(NH2Br))(CO)9](3) and[Os3IrCp*(m-Cl)2(h2, m3-C5H3N(NH)Br)(CO)7](4), In: , Journal of Organometallic Chemistry . 2008, 693: 1528-1535.

 

Lee Y.B. and Wong W.T., Synthesis and Characterisation of High-nuclearity Osmium-silver Mixed-metal Clusters , Chemical Communications. 2007, 3924-3926.

 

Paital A.R., Wong W.T., Aromi G. and Ray D., New [LNiII2]+ Complex Incorporating 2-formyl or 2,6-diformyl-4-methyl Phenol as Inhibitors of the Hydrolysis of the Ligand L3-: Ni...Ni Ferromagnetic Coupling and S=2 Ground States , Inorganic Chemistry. 2007, 46: 5727-5733.

 

Wong K.L., Law G.L., Murphy M.B., Tanner P.A., Wong W.T., Lam P.K.S. and Lam M.H.W., Functionalized Europium Nanorods for In Vitro Imaging , Inorganic Chemistry. 2008, 47: 5190-5196.

 

Wong S.Y., Gu Y., Sze-To L. and Wong W.T., An Open-channel Architecture Assembly from the [Os3(CO)8{m-h3-ON=CPh(NC5H4)}2] Cluster , Crystengcomm. 2008, 10: 29-33.

 

Wong W.T., Co-Editor of Acta Crystallographica Section E (2006-2008), International Union of Crystallography. 2007.

 

Wong W.T., Member of Editorial Advisory Board (2006-2008), Current Chemical Biology, Bentham Science Publishers. 2007.

 

Wong W.T., Member of Editorial Advisory Board (2006-2008), European Journal of Inorganic Chemistry, VCH-Wiley . 2007.

 

Wong W.T., Member of Editorial Advisory Board (2006-2008), Journal of Cluster Science, Plenum Publishing, 2007. 2007.

 

Wong W.T., Member of Editorial Advisory Board , Open Journal of Crystallography, Bentham Science Publishers. 2007.

 

Wong W.T., Member of Editorial Advisory Board , Open Journal of Structural Biology, Bentham Science Publishers. 2007.

 

Wong W.T., Member of Editorial Advisory Board , Research Letters in Inorganic Chemistry, Hindawi Publishing. 2007.

 

Wong W.T., Member of Editorial Advisory Board, Internatioal Journal of Biomedical Nanoscience and Nanotechnology. 2007.

 

Wong W.T., Member of Editorial Advisory Board, Open Journal of Inorganic Chemistry, Bentham Science Publishers. 2007.

 

Yeung C.T., Teng P.F., Yeung H.L., Wong W.T. and Kwong H.L., Catalytic and Asymmetric Cyclopropanation of Alkenes Catalysed by Rhenium(I) Bipyridine and Terpyridine Tricarbonyl Complexes , Organic & Biomolecular Chemistry . 2007, 3859-3864.

 

Researcher : Wu R



List of Research Outputs

 

Wu R., Fung Y.S. and Yeung W.S.B., Microfluidic Chip-capillary Electrophoresis for 2-D Separation of Proteins, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:49, pp 5:141.

 

Researcher : Xia W



List of Research Outputs

 

Cun S., Li H., Xia W., Lin M.C. and Sun H., Ni2+/Bi3+-Binding Properties Indicate the Heat-Shock Protein A (HspA) an Important Role for both Nickel Transport and Drug Sensitivity of Helicobacter pylori, 21st Symposium of The Protein Society, Boston, Massachusetts, USA July 21-25. 2007.

 

Li H., Cun S., Xia W., Lin M.C. and Sun H., Metal Binding Properties of Heat-Shock Protein A (HspA) , 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Researcher : Xiang H



Project Title:

Surface Modification of Zinc Oxide Core-Shell Dendron Nanoparticles with Porphyrin Dyes

Investigator(s):

Xiang H, Lai PT, Che CM

Department:

Electrical & Electronic Engg

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Zinc oxide (ZnO) nanoparticles or nanocrystals with its wide band gap (3.4 eV) and large exciton binding energy (60 meV) have been of particular interest for catalysts, sensors and optoelectronic devices. Since the luminescence characteristics of ZnO quantum dots are size-dependent, the size control is very important. The strategy to control the particle sizes is to modify the surface of ZnO nanoparticles by encapsulating an organic capping agent on the nanoparticle surfaces such as alkylthiols, polymer micelles, or using coordinating solvent such as dimethyl sulfoxide, N,N-dimethylformamide and tri-n-octylphosphine oxide. Many research groups have focused on the superior optoelectronic properties of quantum-sized organic-inorganic nanocomposites. The hybrid nanocomposites with functional organic caps or dendron not only prevent aggregation of the quantum dots but also possess advantages of the organic cap or dendron.

 

List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Stallinga P., Vellaisamy A.L.R., Xu Z., Xiang H. and Che C.M., Metal-Insulator-Meta Transistors , Advanced Materials. 2008, 20: 2120-2124.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Xiang H., Lai S.W., Lai P.T. and Che C.M., Phosphorescent Platinum(II) Materials for OLED Applications, In: Hartmut Yersin, Highly Efficient OLEDs with Phosphorescent Materials. John Wiley & Sons (Asia) Pte. Ltd., 2007.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Che C.M., Lai P.T., Zeng P.J., Niu F.F., Liu Y.W., Tang W.Q., He C.J. and Niu H.B., Star-configured Carbazole as an Efficient Near-ultraviolet Emitter and Hole-transporting Material for Organic Light-emitting Devices , Applied Physics Letters. 2008, 92: 073305-1 to 073305-3.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Researcher : Xiao W



List of Research Outputs

 

Liu Y., Xiao W., Wong M.K. and Che C.M., Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin , Organic Letters. 2007, 9: 4107-4110.

 

Researcher : Xie J



List of Research Outputs

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Xie J., Synthesis, Structure and Spectroscopic Properties of Primary and Secondary Phosphine Complexes of Iron, Ruthenium and Osmium Porphyrins (PhD Thesis) . 2007.

 

Researcher : Xie J



List of Research Outputs

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Xie J., Synthesis, Structure and Spectroscopic Properties of Primary and Secondary Phosphine Complexes of Iron, Ruthenium and Osmium Porphyrins (PhD Thesis) . 2007.

 

Researcher : Xu M



List of Research Outputs

 

Chu I.K., Zhao J., Xu M., Siu S.O., Hopkinson A.C. and Siu K.W.M., Are the Radical Centers in Peptide Radical Cations Mobile? The Generation, Tautomerism, and Dissociation of Isomeric a-Carbon-Centered Triglycine Radical Cations in the Gas Phase, Journal of the American Chemical Society. 2008, 130: 7862-7872.

 

Researcher : Xu S



List of Research Outputs

 

Xu S., Wong C.L., Tong H.Y., Chung S.S.M. and Ko C.B., Phosphorylation By Casein Kinase 1 Regulates Tonicity-induced Osmotic Reponse Element-binding Protein/tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking, Journal Of Biological Chemistry. 2008, 283: 17624-34.

 

Researcher : Xu Z



List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Stallinga P., Vellaisamy A.L.R., Xu Z., Xiang H. and Che C.M., Metal-Insulator-Meta Transistors , Advanced Materials. 2008, 20: 2120-2124.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Che C.M., Lai P.T., Zeng P.J., Niu F.F., Liu Y.W., Tang W.Q., He C.J. and Niu H.B., Star-configured Carbazole as an Efficient Near-ultraviolet Emitter and Hole-transporting Material for Organic Light-emitting Devices , Applied Physics Letters. 2008, 92: 073305-1 to 073305-3.

 

Researcher : Xu Z



List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Stallinga P., Vellaisamy A.L.R., Xu Z., Xiang H. and Che C.M., Metal-Insulator-Meta Transistors , Advanced Materials. 2008, 20: 2120-2124.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Che C.M., Lai P.T., Zeng P.J., Niu F.F., Liu Y.W., Tang W.Q., He C.J. and Niu H.B., Star-configured Carbazole as an Efficient Near-ultraviolet Emitter and Hole-transporting Material for Organic Light-emitting Devices , Applied Physics Letters. 2008, 92: 073305-1 to 073305-3.

 

Researcher : Xue J



List of Research Outputs

 

Du Y., Ma C., Kwok W.M., Xue J. and Phillips D.L., Time-Resolved Resonance Raman Identification and Structural Characterization of a Light Absorbing Transient Intermediate in the Photoinduced Reaction of Benzophenone in 2-Propanol, Journal of Organic Chemistry. 2007, 72: 7148-7156.

 

Du Y., Xue J., Ma C., Kwok W.M. and Phillips D.L., Time-resolved Resonance Raman and Density Functional Theory Study of the Photochemistry of 4-Benzoylpyridine in Acetonitrile and 2-Propanol , Journal of Raman Spectroscopy . 2008, 39: 503-514.

 

Xue J., Du Y., Chuang Y.P., Phillips D.L., Wang J., Luk C., Hadad C.M. and Platz M.S., Time-Resolved Resonanc Raman Observation of the Dimerization of Didehydroazepines in Solution , Journal of Physical Chemistry A. 2008, 112: 1502-1510.

 

Xue J., Chan P.Y., Du Y., Guo Z., Chung W.Y., Toy P.H. and Phillips D.L., Time-Resolved Resonance Raman Investigation of the 2-Fluorenylnitrenium Ion Reactions with C8 Guanosine , Journal of Physcial Chemistry B. 2007, 111: 12676-12684.

 

Researcher : Yam CY



List of Research Outputs

 

Wang F., Yam C.Y., Chen G., Wang X.J. and Fan K.N., Linear Scaling Time-dependent Density-functional Thight-binding Method for Absorption Spectra of Large Systems , Physical Review B. 2007, 76: 045114-1 - 045114-6.

 

Researcher : Yam VWW



Project Title:

Synthesis and aggregation studies of Platinum(II) complexes in various media and environments

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2003

 

Abstract:

To design, synthesize, and characterize various tridentate organic ligands; to incorporate the newly synthesized ligands into platinum metal centres and to characterize the metal complexes formed; to investigate the spectroscopic, electronic absorption, emission, and electrochemical properties of these platinum (II) complexes; to study the aggregation behaviour of these complexes in various solvent environments and microenvironments and to investigate the effects of environments on the electronic absorption and emission properties of these metal complexes; to explore and assess their potential for application as reporter of various environments.

 

Project Title:

Design and Synthetic Strategies Towards Novel Classes of Photochromic Metal-Containing Compounds

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To design, synthesize, and characterize various functionalized diarylethene ligands; to incorporate the newly synthesized ligands into selected metal centers and to characterize the metal complexes formed; to investigate the spectroscopic, electronic absorption, emission, and photochromic properties of the newly synthesized ligands and their metal complexes; to correlate their measured optical and photochromic properties as well as the thermal stabilities of their photocyclized forms with the electronic and structural aspects of the diarylethenes and the metal complexes.

 

Project Title:

Synthesis and Structure of Luminescent Redox-Active Carbon-Rich Mixed-Metal Complexes of Iron(II), Rhenium(I), and Platinum(II) -- From Molecules Towards Multi-Functional Molecular Devices

Investigator(s):

Yam VWW, Wong MC

Department:

Chemistry

Source(s) of Funding:

France/Hong Kong Joint Research Scheme - Travel Grants

Start Date:

01/2005

 

Abstract:

To synthesis various luminescent redox-active carbon-rich mixed-metal complexes of iron(II), rhenium(I) and platinum(II); to characterize the newly synthesized mixed-metal complexes structurally and spectroscopically; to investigate their spectroscopic, electrochemical, and luminescent behaviour, and to fabricate luminescent redox-active molecular device; to study the electronic structures of these complexes by means of density functional theory method; and to correlate their physical properties with the results obtained from theoretical studies.

 

Project Title:

A proposal submitted to URC for seed funding under the research theme on organic optoelectronics

Investigator(s):

Yam VWW, Che CM, Lai PT, Xu SJ, Djurisic A, Chan WK

Department:

Chemistry

Source(s) of Funding:

Seed Funding for Strategic Research Theme

Start Date:

05/2005

 

Abstract:

To identify and build on existing strengths and efforts of research in HKU a multiplinary collaborative research team towards developing world-cleass excellence in organic optoelectronics research through the integration of research expertise and efforts in chemistry, physics and engineering. To accelerate and foster interdisciplinary research between the fields of chemistry, physics, and engineering. To establish HKU as a leading research center in materials for organic optoelectronic applications through innovative materials design and identification of novel device applications towards developing an internationally eminent research center and to advocate world-class research in the areas at HKU.

 

Project Title:

Design and Synthetic Strategies Towards Novel Classes of Luminescent Gold Alkynyls

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2005

 

Abstract:

The main objectives of this project are: (1) To design, synthesize, and characterize various nitrogen donor-containing ligands and mono-, di-, and tri- alkynes (2) To incorporate the newly synthesized nitrogen donor-containing ligands into gold metal centre to give the chlorogold precursor complexes and to characterize the precursor metal complexes formed (3) To incorporate the alkynyl ligands into the gold precursor complexes to give the target gold(III) alkynyl complexes and to characterize them (4) To investigate the electronic absorption, luminescence and electrochemical properties of the chlorogold precursor complexes and target gold(III) alkynyl complexes (5) To correlate the optical and luminescence properties of this highly novel class of gold(III) alkynyl complexes with the electronic and structural aspects of the ligands and the complexes, and to explore their potential for applications as triplet organic light-emitting materials

 

Project Title:

Carbon-rich metal-containing molecular and nano-scale functional materials

Investigator(s):

Yam VWW, Kwok HS, Chan WK, Tang BZ, Xu B, Cheah KW, Cui X

Department:

Chemistry

Source(s) of Funding:

Central Allocation Vote - Group Research Project

Start Date:

03/2006

 

Abstract:

To assessmble a multi-disciplnary and multi-institutional collaborative research team towards developing world-class excellence in carbon-rich metal-containing molecular and nano-scale functional materials; to generate, through the synergism of innovative materials design and synthesis, physical characterization, new knowledge in the study of carbon-rich metal-containing molecular and nano-scale functional materials and their properties; to explore the potential of these carbon-rich mdtal-containing molecular and nano-scale functional materials in various functions and applications, such as luminescence, photoconductors, nonlinear optics, organogels, liquid crystals, and molecular wires and junctions; to promote the visibility of Hong Kong as a world-recognised area of excellence in carbon-rich metal-containing molecular and nano-scale functional materials research.

 

Project Title:

Design and synthesis of novel classes of luminescent transition metal complexes of functionalized imidazole and N-heterocyclic carbene ligands and their related imidazolium salts

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2006

 

Abstract:

(1) To design, synthesize, and characterize various functionalized imidazole-containing ligands and imidazolium salts, (2) To incorporate the newly synthesized imidazole-containing ligands into selected metal centres and to characterize the metal complexes formed, (3) To utilize the various functionalized imidazolium salts as precursors for the synthesis of functional N-heterocyclic carbene complexes of selected metals and to characterize them, (4) To investigate the electronic absorption, luminescence and functional properties of the newly synthesized imidazole-containing ligands and imidazolium salts and their metal complexes, (5) To correlate their optical, luminescence and functional properties with the electronic and structural aspects of the ligands, salts and complexes, and to explore their potential for applications as molecular functional materials. (6) Impact: There has been a growing interest in the rational design and synthesis of advanced materials with unique properties for technological developments. Despite numerous works on N-heterocyclic carbenes (NHCs) and their metal complexes, most of the studies were focused on their structure and bonding, and their catalytic functions and reactivities, with the utilization of these classes of compounds, as well as their related imidazoles and their imidazolium salts, as novel materials for other functions much less explored. Although there have been some recent reports on the luminescence properties of metal carbenes and the liquid crystalline properties of metal complexes of imidazoles and imidazolium salts, the work is still rather limited and relatively underdeveloped and unexplored. Thus it is the aim of this project to design and synthesize novel classes of transition metal complexes of functionalized imidazole and NHC ligands and their related imidazolium salts, to study their functional properties, and to explore their potential as new classes of molecular functional materials. It is envisaged that with appropriate design and introduction of various functional groups into the imidazole ligands and imidazolium precursors, novel classes of transition metal complexes with interesting functional properties could be generated. We believe that the strong sigma-donating properties of the NHCs would give rise to metal complexes with rich luminescence properties, and an exploration into the luminescence behaviour, nonlinear optical (NLO) properties, and electronic communication and interaction of these imidazole-based systems would yield interesting and novel findings. (7) In addition, the metal NHCs with the strong metal-carbon bond, which unlike the metal phosphines, are believed to be less susceptible to photodissociation reactions. These, together with the less interfering ligand-centred chromophoric behaviour of the NHC moiety, would make them suitable candidates for the exploration of the photophysical and luminescence properties of their metal complexes. The present project should contribute not only to the basic understanding of the optical, luminescence and photochromic behaviour of the newly synthesized molecules and metal complexes, but also would represent a new research initiative and direction towards the design and discovery of new classes of metal-containing molecular materials capable of exhibiting rich functional properties.

 

Project Title:

Synthesis, aggregation and self-assembly of luminescent functional molecules - from solutions to polymers, ordered thin films, inorganic-organic hybrids, and supramolecular and nano-assemblies

Investigator(s):

Yam VWW, Wu LX, Wong MC, Shen JC

Department:

Chemistry

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2007

 

Abstract:

To design, synthesize, and characterize various functionalized organic molecules, donor ligands, polymers and nanoparticles; to incorporate the newly synthesized donor ligands into selected metal centres and to characterize the metal complexes formed; to investigate the spectroscopic, electronic absorption and photoluminescence properties of the newly synthesized functionalized organic molecules, metal complexes, polymers and nanoparticles; to study the spectroscopic properties and the aggregation behaviour of these molecules and metal complexes in polymers, ordered thin films, inorganic-organic hybrids, and supramolecular and nano-assemblies; to explore their potential function as optically addressable and luminescence functional materials, switches and probes of micro-environmental and conformational changes.

 

Project Title:

Design and Synthesis of Novel Classes of Metallogels

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2007

 

Abstract:

In recent years, there has been a growing interest in the search for new advanced nanostructured materials with unique properties for technological developments. One of the areas that is rapidly developing and is attracting a lot of attention recently is in the area of soft matters, which can have many different forms and great potential for a wide range of materials applications. One interesting class of soft matters that has attracted enormous attention is organogels, especially those in which the three-dimensional structural networks are based on the self-assembly of low molecular-mass organic gelators (LMOGs). Recent interest in supramolecular assembly via weak non-covalent interactions has also led to a growing interest in the study of low molecular weight organogels. On the contrary, metallogels were relatively less explored. Despite recent growing interest in the development of low molecular-weight organogels, most of the works have been directed towards the utilization of noncovalent van der Waals’ forces, π-π stacking and hydrogen bonding interactions as the driving force for gelation. Moreover, despite these studies and growing interest in this area of research, most of the materials employed in these studies have been very limited and exploration into new classes of molecular materials with more diverse structures and varieties is rare. Recently, there has been a growing interest in the study of metallogel, owing to the rich spectroscopic and luminescence properties exhibited by a variety of transition metal complexes. Despite the recent interest in metallophilicity and its utilization in directing supramolecular assembly, corresponding studies in the exploration of metal-metal interactions for metallogel formation are rare. In view of the propensity of the platinum(II) terpyridyl system to form Pt∙∙∙Pt and π-π stacking interactions, it is anticipated that such interactions may provide an additional driving force for the gelation process and hence improve the stability of the metallogel. Moreover, the interesting photophysical properties of the platinum(II) terpyridyl system may give rise to interesting changes in the spectroscopic and luminescence behavior during the sol-gel transition and serve as a reporter for changes in the microenvironment. These, together with our interest in metal-metal and π-π stacking interactions, have prompted us to explore the utilization of the platinum(II) terpyridyl system and other related platinum(II) systems in metallogel synthesis. It is believed that an exploration into the design and synthesis of new classes of metallogels would represent a challenging area of research. Therefore the objective of this project is to design and synthesize new classes of metallogels based on functionalization of the platinum(II) system, which are expected to show interesting optical and and gelation properties. Variation of the electronic and steric properties of the ligands will also be made to tune the stability and gelation properties of these metallogels. Investigation of their gelation and photophysical properties and their structure-property relationships will also be made. It is envisaged that with the appropriate design and judicious choice of the ligands and the metal complexes, novel classes of metallogels with interesting optical and gelation properties could be obtained.

 

List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Lam S.W.H., Cheng C.C. and Yam V.W.W., Computational Studies on the Photophysical Properties and NMR Fluxionality of the Tetranuclear Copper(I) Complexes [Cu4(m-dppm)(m4-E]2+(E= PPh and S) , 234th ACS Meeting . 2007, INOR-733.

 

Li M., Chen Z., Zhu N., Yam V.W.W. and Zu Y., Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cations Binding , Inorganic Chemistry. 2008, 1218-1223.

 

Li M., Ko C.C., Duan G., Zhu N. and Yam V.W.W., Functionalized Rhenium(I) Complexes with Crown Ether Pendants Derived from 1,10-Phenanthroine: Selective Sensing for Meta Ions , Organometallics. 2007, 6091-6098.

 

Li M., Chen Z., Yam V.W.W. and Zu Y., Multifunctional Ruthenium (II) Polypyridine Complex-Based Core-Shell Magnetic Silica Nanocomposites: Magnetism, Luminescence, and Electrochemiluminescence , ACS Nano. 2008, 2: 905-912.

 

Lo H.S., Yip S.K., Zhu N. and Yam V.W.W., The First Example of a Pt...Pt Interectation in Platinium (II) Complexes Bearing Bulky Tri-tert-Butyl-2,2':6',2"- Terpyridine Pendants via Conformational Control of the Calix[4] Arene Moiety, , Dalton Transactions. 2007, 4386-4389.

 

Lu C., Zu Y. and Yam V.W.W., Nonionic Surfactant-capped Gold Nanoparticles as Postcolumn Reagents for High-performance Liquid Chromatography Assay of Low-molecular-mass Biothiols , Journal of Chromatography A. 2007, 1163: 328-332.

 

Moussa J., Wong M.C., Chamoreau L.M., Amouri H. and Yam V.W.W., Luminescent 1D Chain of Platinum(II) Terpyridyl Units with p-Dithiobenzoquinone Organometallic Linker: Self-aggregation Imparted from Pt...Pt/p-p Interactions , Dalton Transactions. 2007, 3526-3530.

 

Sun Q.F., Wong M.C., Liu L.X., Huang H.P., Yu X.Y., Yam V.W.W., Yi Y.Z., Pan Y.J. and Yu K.C., Self-assembly, Structures, and Photophysical Properties of 4,4'-Bipyrazolate-linked Metallo-Macrocycles with Dimetal Clips, Inorganic Chemistry. 2008, 47: 2142-2154.

 

Tam Y.Y., Lam S.W.H., Wong M.C., Zhu N. and Yam V.W.W., Luminescent Alkynylplatinum(II) Complexes of 2,6-Bis (N-alkylbenzimidazol-2'-yl) Pyridine-Type Ligands with Ready Tunability of the Nature of the Emissive States by Solvent and Electronic Property Modulation , Chemistry - A European Journal. 2008, 14: 4562-4576.

 

Yam V.W.W., Editioral Advisory Board (From July 2007 - June 2008), ACS Nano. American Chemical Society, 2007.

 

Yam V.W.W., Distinguished Research Achievement Award , The University of Hong Kong . 2008.

 

Yam V.W.W., From Design to Assembly of Luminescent Metal-Based Molecular Functional Materials , Invited Speaker to give a 20-minute Lecture at the Symposium on "Metal-Containing and Metallo-Supramolecular Polymers and Materials" at the American Chemical Society (ACS) National Meeting, Boston, U.S.A.,August 19-23, 2007. 2007.

 

Yam V.W.W., From Design to Assembly of Luminescent Platinum - and Gold-based Molecular Functional Materials , Keynote Speaker to Give a 30-Minute Lecture at the 1st Asian Conference on Coordination Chemistry (1st ACCC), Okazaki, Japan, July 29 - August 2, 2007. 2007.

 

Yam V.W.W. and Wong M.C., From Simple Molecules to Molecular Functional Materials and Nanoscience , In: Zikang Tang and Ping Sheng (eds.), Nanoscale Phenomena: Basic Science to Device Applications . Springer, 2007, Vol. 2 (Chapter 19): 217-234.

 

Yam V.W.W., From-Metal-Metal Interactions to Luminescent Assemblies, from October 8-10, 2007, International Karlsruhe Nanoscience Workshop: Symposium on Metal-Rich Compounds . Karlsruhe, Germany, 2007, p.8.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lecture in March 2008, Department of Chemistry, California Institute of Technology. California, USA, 2008.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lecture in March 2008, Department of Chemistry, Massachusetts Institute of Technology. Cambridge, USA, 2008.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lecture in March 2008, Department of Chemistry, University of Califormia Los Angles . Los Angeles, USA, 2008.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lecture in March, 2008, Department of Chemistry, Harvard University. Cambridge, USA, 2008.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lectures, in March 2008 , Department of Chemistry, University of Illiniois . Urbana-Champagne, USA, 2008.

 

Yam V.W.W., Hong Kong Fulbright Distinguished Scholar Lecutre in March 2008, Department of Chemistry, University of California, Berkeley. Berkeley, USA, 2008.

 

Yam V.W.W., International Editoral Board, from July, 2007 upto present, Gold Bulletin . World Gold Counicl, 2007.

 

Yam V.W.W., Member of the International Committee , 1st Asian Conference on Coordination Chemistry (ACCC), Okazaki, Japan . 2007.

 

Yam V.W.W., Member of the International Committee, from August 2007 upto Present , 1st Asian Conference on Coordination Chemistry (ACCC). Okazaki, Japan, 2007.

 

Yam V.W.W., Member of the International Scientific Committee, The Symposium Entitled "New Routes to Inorganic Materials, Films and Nanocrystals" at the International Conference on Materials for Advanced Technologies (ICMAT 2007). Singapore, 2007.

 

Yam V.W.W., Member of the Organizing Committee, from January 16-18, 2008, UK-Hong Kong Frontier of Science Symposium (Jointly Organized by the Royal Society UK and Croucher Foundation) . Hong Kong, 2008.

 

Yu C., Chan H.Y., Wong M.C. and Yam V.W.W., Polyelectrolyte-induced Self-assembly of Positively Charged Alkynylplatinum(II) - Terpyridyl Complexes in Aqueous Media , Chemistry - A European Journal. 2008, 4577-4584.

 

Yu S.Y., Sun Q.F., Lee K.M., Cheng C.C., Li Y.Z. and Yam V.W.W., Au36 Crown: A Macrocyclization Directed by Metal-Metal Bonding Interactions , Angewandte Chemie International Edition. 2008, 47: 4551-4554.

 

Zhang J., Chu W.K., Zhu N. and Yam V.W.W., Synthesis, Characterizationl, Langmuir - Blodgett Film-Forming Property, and Second-Order Nonlinear Optical Study of Rhenium(I) and Ruthenium(II) Diimine Complexes , Organometallics. 2007, 5423-5429.

 

de Montigny F., Argouarch G., Roisnel T., Toupet L., Lapinte C., Lam C.F., Tao C.H. and Yam V.W.W., Syntheses, Structures, and Properties of Some Piano-stool Iron Acetylides Bearing a Functional Anthracenyl Group, Organometallics. 2008, 27: 1912-1923.

 

Researcher : Yan B



Project Title:

Non conventional nanofabrication methods and microfluidic devices

Investigator(s):

Yan B

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

09/2005

 

Abstract:

This project will be conducted at HKU’s Nanotechnology Research Institute. The objective of the program is to develop non conventional nanofabrication technologies and microfluidic devices for advanced research and industrial applications. Research activities will focus on following three areas: 1) to develop non conventional nanofabrication methods that allow the realization of various microchannels and integrated microsystems on a large scale and at low cost; 2) to design and fabricate microfluidic devices suitable for new experiences in chemistry and biology; 3) to apply these technologies to biotechnology, biomedical research and clinical diagnostics.

 

Project Title:

Novel organic bipolar devices

Investigator(s):

Yan B

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

Organic electronics are beginning to make significant inroads into the commercial world. Interest in organic electronics stems from the potential for producing low-cost, large-area, lightweight and flexible devices which can integrate functionalities currently requiring more expensive conventional semiconductors and components. The development of novel organic electronic devices, especially integrated organic electronic devices, is not only a gateway for a variety of applications, but also of great relevance for the general purpose of achieving highly integrated optoelectronic system. This proposal proposes two novel organic bipolar devices: 1) high efficiency white organic light-emitting devices (WOLEDs) with simplified device architecture 2) all-organic heterojunction bipolar transistors (HBTs). One of the objectives is to develop WOLEDs with high brightness, high efficiency, and long lifetime for full-color flat-panel display, backlighting and alternative lighting. Another objective is to develop all- organic HBTs with good dc performance for OLEDs' drive circuits or as new light-emitting devices. The purpose of the proposed project is as follows: 1)White organic light-emitting devices (WOLEDs) are of great importance because they can be used in full-color flat-panel displays with color filters, backlighting and as alternative lighting sources. The challenges facing WOLED technology stem mainly from the fact that fluorescence or phosphorescence emission from typical organic materials only spans about one third of the visible spectrum. To achieve balanced white light emission, researchers have to use multiply doped emissive layer architecture[1] or multiple emissive layer architecture [2-3]. However, multiply doped emissive layer architecture is problematic because energy readily transfers from the higher energy blue dye to the green dye and from the green dye to the red dye[4]. The multiple emissive layer architecture can overcome the energy transfer problem, but the device architecture is considerably more complicated and expensive to fabricate, due to the large number of materials and interfaces compared with monochromatic OLEDs [5]. We therefore propose to develop phosphorescent WOLEDs with simplified device architecture, especially single emissive layer and single dopant architecture. The realization of high efficiency phosphorescent WOLEDs with simplified architecture will not only improve the quality of flat-panel display, but will also simplify fabrication complexity, and significantly reduce the fabrication costs. 2) Organic thin-film transistors (OTFTs) are of interest for a variety of large-area electronic applications, such as display, sensors, and electronic barcodes. The challenges facing organic thin-film transistor (OTFT) technology stem mainly from low mobility of carriers in organic materials, which limits the speed of the OTFTs. In contrast with OTFTs, organic HBTs have several advantages, such as excellent high-speed performance, larger current-handling capabilities and higher transconductance. Therefore organic HBTs are more suitable as a driver of OLEDs. On the other hand, the fabrication process of OLEDs and organic HBTs is completely compatible (vertical multilayer growth). It may become possible to integrate WOLEDs and OHBTs in an optoelectronic system or a device. In addition, we expect that organic HBTs, like OLEDs, may possess light-emitting ability. If so, all-organic HBTs represent a novel class of organic devices, and could pave the way for the realization of nanoscale light sources and highly integrated optoelectronics. [1] B. W. D’Andrade, R. J. Holmes, S. R. Forrest, Adv. Mater. 2004, 16, 624. [2] B. W. D’Andrade, M. E. Thompson, S. R. Forrest, Adv. Mater. 2002, 14, 147. [3] S. Tokito, T. Lijima, T. Tsuzuki, F. Sato, Appl. Phys. Lett. 2003, 83, 2459. [4] V. Adamovich, J. Brooks, A. Tamayo, A. M. Alexander, P. I. Djurovich, M. E. Thompson, C. Adachi, B. W. D’Andrade, S. R. Forrest, New J. Chem. 2002, 26, 1171. [5] B. W. D’Andrade, R. J. Holmes, S. R. Forrest, Adv. Mater. 2004, 16, 1585.

 

List of Research Outputs

 

Chen W., Xiang H., Xu Z., Yan B., Vellaisamy A.L.R., Che C.M. and Lai P.T., Improving efficiency of organic photovoltaic cells with pentacene-doped CuPc layer, In: American Institute of Physics, Applied Physics Letters. 2007, 91: 191109.

 

Vellaisamy A.L.R., Wong E.L.M., Ko B.C.B., Chao C.T., Yan S.C., Yan B., Wu J.C. and Che C.M., Ambipolar Charge Transport in DNA Molecules, Advanced Materials. Wiley InterScience, 2008, 20: 1258-1262.

 

Xiang H., Xu Z., Vellaisamy A.L.R., Yan B., Chan S.C., Che C.M. and Lai P.T., Deep-red to Near-infrared Electrophosphorescence Based on Bis (8-hydroxyquinolato) Pantinum(II) Complexes , Applied Physics Letters. 2008, 92: 163305-1 to 163305-3.

 

Yan B., Cheung C.C., Kui C.F., Xiang H., Vellaisamy A.L.R., Xu S.J. and Che C.M., Efficient white organic light-emitting devices based on phosphorescent platinum(II)/fluorescent dual-emitting layers, Advanced Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2007, 19: 3599-3603.

 

Yan B., Cheung C.C., Kui C.F., Vellaisamy A.L.R., Che C.M. and Xu S.J., High-efficiency orange and yellow organic light-emitting devices using platinum(II) complexes containing extended π-conjugated cyclometalated ligands as dopant materials, Applied Physics Letters. New York, American Institute of Physics, 2007, 91: 063508: 1-3.

 

Researcher : Yan J



List of Research Outputs

 

Che C.M., Xiang H., Chui S.Y., Xu Z., Vellaisamy A.L.R., Yan J., Fu W.F. and Williams I.D., A High-Performance Organic Field-Effect Transistor Based on Platinum(II) Porphyrin: Peripheral Substituents on Porphyrin Ligand Significantly Affect Film Structure and Charge Mobility, Chemistry - An Asian Journal. 2008, 3: 1092.

 

Researcher : Yan K



List of Research Outputs

 

Yan K., Proteomic and Biochemical Studies of Cytotoxic Gold(I), Silver(I) and Rhodium(II) Complexes (PhD Thesis) . 2008.

 

Researcher : Yang D



Project Title:

HKU-Fudan Joint Laboratory on molecular design and synthesis - peptidominetics for drug discovery

Investigator(s):

Yang D, Chen G

Department:

Chemistry

Source(s) of Funding:

Vice-Chancellor's Office - General Award

Start Date:

03/2002

 

Abstract:

To develope chemical methods to provide a broad structural variety of aminoxy acids for the construction of combinatorial libraries; to explore the novel secondary structures of peptides containing [alpha]- and [beta]-aminoxy acids; to investigate the potential aminoxy acids in drug design.

 

Project Title:

Aminoxy peptides as synthetic chloride channels

Investigator(s):

Yang D

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To design and synthesis of cyclic [alpha]-aminoxy peptides as models of chloride channels; to design and synthesis of linear [alpha]-aminoxy peptides as models of chloride channels; to characterize of synthetic chloride channels.

 

Project Title:

Design and synthesis of methionine aminopeptidase-2 inhibitors as anti-angiogenic agents

Investigator(s):

Yang D, Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To develop an expedient route to construct the common core structure of fumagillin and ovalicin; to design, synthesis and biological evaluations fumagillin analogs as irreversible inhibitors of MetAP-2; to design, synthesis and biological evaluations fumagillin analogs as reversible inhibitors of MetAP-2.

 

Project Title:

Developing highly specific and sensitive fluorescent probes for peroxynitrite detection in biological systems

Investigator(s):

Yang D

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

The main object of this project is to investigate fluorescent probes based on fluorescein and BODIPY chromophores that are commonly used in biological imaging. The advent of a simple, sensitive and specific probe for peroxynitrite detection is of great importance in the biomedical research of peroxynitrite.

 

Project Title:

Developing aminoxy acids-containing peptide mimics as small moleucle inhibitors of protein-protein interactions

Investigator(s):

Yang D

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2006

 

Abstract:

(1) Design and synthesis of aminoxy acids-containing peptides that form stable helical structures in water (2) design and synthesis of aminoxy acids-based peptides as α-helix mimics to inhibit protein-protein interactions such as the p53/hDM2 interaction

 

Project Title:

Peptidomimetics: Design, Synthesis and Biomedical Applications

Investigator(s):

Yang D, Xu B, Sun H

Department:

Chemistry

Source(s) of Funding:

Central Allocation Vote - Group Research Project

Start Date:

02/2007

 

Abstract:

1) Design, synthesis, and biological activity of aminoxy acids-based peptides; 2) Using peptidomimetics to understand the transport process of small anions and cations across biological membranes; 3) Developing hydrogels based on aminoxy acids; and 4) Pharmacokinetic studies of selected bioactive peptides containing aminoxy acids

 

List of Research Outputs

 

Chen F., Song K., Wu Y.D. and Yang D., Synthesis and Conformational Studies of g-Aminoxy Peptides , Journal of the American Chemical Society. 2008, 130: 743-755.

 

He W. and Yang D., Redesigning Pd(II)-Catalyzed Asymmetric Oxidative Cascade Cyclization, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Lo K.Y., Yip P.K.T. and Yang D., Palladium(II) Catalyzed Oxidative Tandem Cyclizations of Alkenyl Amides, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Peng T. and Yang D., Development of Fluorescent Probes for Detection of Peroxynitrite , The 234th American Chemical Society National Meeting, Boston, U.S.A., August 19-23, 2007.

 

Sun Z., Liu F., Chen Y., Tam P.K.H. and Yang D., A Highly Specific BODIPY-based Fluorescent Probe for the Detection of Hypochlorous Acid, Organic Letters. 2008, 10(11): 2171-2174.

 

Sun Z., Yang D., Chen Y. and Liu F., Reagents for Detection of Hypochlorous Acid, U.S. Non-Provisional Patent Application (No. 12/034,670). 2008.

 

Wong K.F., Chan J.K.Y., Chan K.L., Tam P.K.H., Yang D., Fan S.T. and Luk J.M.C., Immunochemical characterization of the functional constituents of tripterygium wilfordii contributing to its anti-inflammatory property, Clinical and Experimental Pharmacology and Physiology. 2008, 35(1): 55-59.

 

Yang D., A Small Synthetic Molecule Self-Assembles to form Chloride Channels in Cell Membranes , The IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea, June 15, 2008.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis , The 3rd Roche Shanghai Drug Discovery Symposium, Shanghai, November 15, 2007.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis , The RSC-GSK UK-Singapore Symposium Entitled "Contemporary Organic Synthesis, Methods and Techniques". 2008.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Products Synthesis, Symposium Entitled "Trend in Organic Chemistry -- Metal Mediated Reactions", Göteborg, Sweden, December 15, 2007 . 2007.

 

Yang D., Development of Polymers for Electroplating Waste Water Purification, Polymer-supported Reagents for Organic Synthesis and Heterogeneous Catalysts for Aerobic Alcohol Oxidation (MPhil Thesis) CATALYSTS FOR AEROBIC ALCOHOL OXIDATION REACTIONS (MPhil Thesis) . 2008.

 

Yang D., Entitled "Contemporary Organic Synthesis, Methods and Techniques", Keynote Lecture, the RSC-GSK UK-Singapore Symposium, Singapore, February 15, 2008. 2008.

 

Yang D., In the Search of Miracle Drugs , The 13th HKU Medical Research Conference, Hong Kong, January 15, 2008.

 

Yang D., Invited Lecture, the IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea, June 15, 2008. 2008.

 

Yang D., Member of Editorial Advisory Board of Organic Letters (2008 -- ). 2008.

 

Yang D., Novartis Chemistry Lectureship Award (2008). 2008.

 

Yang D., Pleanary Lecture, The 13th HKU Medical Research Conference, Hong Kong, January 15, 2008. 2008.

 

Yang D., lTrend in Organic Chemistry -- Metal Mediated Reactions , Invited Lecture at Symposium in Goteborg, Sweden, December 15, 2007. 2007.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes , 17th International Conference on Organic Synthesis (ICOS 17). 2008.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, In: , The 15th Symposium on Chemistry Postgraduate Research in Hong Kong. 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea. June 15, 2008.

 

Researcher : Yang D



List of Research Outputs

 

Chen F., Song K., Wu Y.D. and Yang D., Synthesis and Conformational Studies of g-Aminoxy Peptides , Journal of the American Chemical Society. 2008, 130: 743-755.

 

He W. and Yang D., Redesigning Pd(II)-Catalyzed Asymmetric Oxidative Cascade Cyclization, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Liu X., Li C. and Yang D., Total Synthesis of Fumagillol, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Lo K.Y., Yip P.K.T. and Yang D., Palladium(II) Catalyzed Oxidative Tandem Cyclizations of Alkenyl Amides, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Peng T. and Yang D., Development of Fluorescent Probes for Detection of Peroxynitrite , The 234th American Chemical Society National Meeting, Boston, U.S.A., August 19-23, 2007.

 

Sun Z., Liu F., Chen Y., Tam P.K.H. and Yang D., A Highly Specific BODIPY-based Fluorescent Probe for the Detection of Hypochlorous Acid, Organic Letters. 2008, 10(11): 2171-2174.

 

Sun Z., Yang D., Chen Y. and Liu F., Reagents for Detection of Hypochlorous Acid, U.S. Non-Provisional Patent Application (No. 12/034,670). 2008.

 

Wong K.F., Chan J.K.Y., Chan K.L., Tam P.K.H., Yang D., Fan S.T. and Luk J.M.C., Immunochemical characterization of the functional constituents of tripterygium wilfordii contributing to its anti-inflammatory property, Clinical and Experimental Pharmacology and Physiology. 2008, 35(1): 55-59.

 

Yang D., A Small Synthetic Molecule Self-Assembles to form Chloride Channels in Cell Membranes , The IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea, June 15, 2008.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis , The 3rd Roche Shanghai Drug Discovery Symposium, Shanghai, November 15, 2007.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis , The RSC-GSK UK-Singapore Symposium Entitled "Contemporary Organic Synthesis, Methods and Techniques". 2008.

 

Yang D., Catalytic Asymmetric Cyclization Reactions for Natural Products Synthesis, Symposium Entitled "Trend in Organic Chemistry -- Metal Mediated Reactions", Göteborg, Sweden, December 15, 2007 . 2007.

 

Yang D., Development of Polymers for Electroplating Waste Water Purification, Polymer-supported Reagents for Organic Synthesis and Heterogeneous Catalysts for Aerobic Alcohol Oxidation (MPhil Thesis) CATALYSTS FOR AEROBIC ALCOHOL OXIDATION REACTIONS (MPhil Thesis) . 2008.

 

Yang D., Entitled "Contemporary Organic Synthesis, Methods and Techniques", Keynote Lecture, the RSC-GSK UK-Singapore Symposium, Singapore, February 15, 2008. 2008.

 

Yang D., In the Search of Miracle Drugs , The 13th HKU Medical Research Conference, Hong Kong, January 15, 2008.

 

Yang D., Invited Lecture, the IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea, June 15, 2008. 2008.

 

Yang D., Member of Editorial Advisory Board of Organic Letters (2008 -- ). 2008.

 

Yang D., Novartis Chemistry Lectureship Award (2008). 2008.

 

Yang D., Pleanary Lecture, The 13th HKU Medical Research Conference, Hong Kong, January 15, 2008. 2008.

 

Yang D., lTrend in Organic Chemistry -- Metal Mediated Reactions , Invited Lecture at Symposium in Goteborg, Sweden, December 15, 2007. 2007.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes , 17th International Conference on Organic Synthesis (ICOS 17). 2008.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, In: , The 15th Symposium on Chemistry Postgraduate Research in Hong Kong. 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea. June 15, 2008.

 

Researcher : Yang M



List of Research Outputs

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Researcher : Yang N



List of Research Outputs

 

Yang N. and Sun H., Biocoordination chemistry of bismuth: recent advances, Coordination Chemistry Reviews. 2007, 251: 2354-2366.

 

Yang N., Bismuth Based Agents and their Interactions with the SARS Helicase and its Metal Binding Domain (PhD Thesis) . 2008.

 

Yang N., Tanner J.A., Zheng B., He M.L., Lu L., Jiang J.Q., Shum K.T., Lin Y., Wong K.L. and Lin M.C., Bismuth Complexes Inhibit the SARS Coronvirus, Angew. Chem. Int. Ed. 2007, 46: 6464.

 

Yang N., Tanner J.A., Zheng B., Watt R.M., He M.L., Lu L., Jiang J., Shum K.T., Lin Y., Wong K.L., Lin M.C., Kung H.F., Sun H. and Huang J., Bismuth complexes inhibit the SARS coronavirus, Angewandte Chemie International Edition. 2007, 46: 6464-6468.

 

Yang N., Tanner J.A., Wang Z., Huang J., Zheng B., Zhu N. and Sun H., Inhibition of SARS coronavirus helicase by bismuth complexes, Chemical Communications. 2007, 4413-4415.

 

Yang N., Tanner J.A., Huang J., Zheng B. and Sun H., Inhibition of the SARS coronavirus by Bismuth Compounds, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Researcher : Yang P



List of Research Outputs

 

Ng S.M., Yang P., Cheng Y., Peng Y., Kung H.F. and Lin M.C., Differential and Critical Roles of Reactive Oxygen Species and Reactive Nitrogen Species in Alcohol-Induced Gene Dysregulations and Birth Defects in Xenopus Embryos, Neuroembryology and Aging. 2007, 4: 155-161.

 

Yang P., Cheung K.C., Peng Y., He M.L., Wu G., Xie D., Jiang B., Huang Q., Chen Z., Lin M.C. and Kung H., Makorin-2 is a Neurogenesis Inhibitor Downstream of PI3K/AKT Signal , The Journal of Biological Chemistry. 2008, 283: 8486-8495.

 

Yeung C.M., Tan Y., Tam S., Lu L., Ko K.H., Yang P., Kung H.F. and Lin M.C., The Antidiabetic Effects of a Dry Powder of Dietary Vegetable and Fruit Mixtures in Diabetic db/db Mice, Biologics: Targets and Therapy. 2008, 2(3): 571-576.

 

Researcher : Yang Y



List of Research Outputs

 

Cho C.K.L., Yang Y., Chu I.K., Haynes R.K. and Sze K.H., 3D Structure Determination and Comparison of Natural Loloatin Family and all L-loloatins by Nuclear Magnetic Resonance Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-18.

 

Jiang M., Chen M., Cao Y., Yang Y., Sze K.H., Chen X. and Guo Z., Determination of the Stereochemistry of 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a Key Intermediate in Menaquinone Buisynthesis , Organic Letters. 2007, 9: 4765-4767.

 

Sze K.H., Wong A.O.L., Yang Y., Zhou H., He M. and Sze K.H., A Brain-specific PACAP in Fish Model: Solution Structure by Nuclear Magnetic Resonance Spectroscopy and Effects on Growth Hormone Release and Gene Expression, International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007 . 2007.

 

Sze K.H., Zhou H., Yang Y., He M., Jiang Y.H. and Wong A.O.L., Pituitary Adenyate Cyclase-Activating Polypeptide (PACPS) as a Growth Hormone (GH)-Releasing Factor in Grass Carp: II. Soution Structure of Brain-Specific PACAP by Nuclear Magnetic Respmamce Spectroscopy and Functiona Studies on GH Release and Gene Expression, Endocrinology . 2007, 148: 5042-5059.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Resonance Assignments of the 27kDa Active from of Maize Ribosone-Inactivating Protein (MOD) by NMR Spectroscopy, Poster Presentation on 16th Triennial Conferenc for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. P1-15.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Solution Structure of a 28 kDa active Mutant of Maize Ribosome-Inactivating Protein (MOD) Studied by NMR Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-19.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., 1H, 13C and 15N Backbone and Side Chain Resonance Assignments of a 28 kDa Active Mutant of Maize Ribosome-inactivating Protein (MOD) , Biomolecular NMR Assignments . 2007, 12: 187-189.

 

Researcher : Yang Y



List of Research Outputs

 

Cho C.K.L., Yang Y., Chu I.K., Haynes R.K. and Sze K.H., 3D Structure Determination and Comparison of Natural Loloatin Family and all L-loloatins by Nuclear Magnetic Resonance Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-18.

 

Jiang M., Chen M., Cao Y., Yang Y., Sze K.H., Chen X. and Guo Z., Determination of the Stereochemistry of 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a Key Intermediate in Menaquinone Buisynthesis , Organic Letters. 2007, 9: 4765-4767.

 

Sze K.H., Wong A.O.L., Yang Y., Zhou H., He M. and Sze K.H., A Brain-specific PACAP in Fish Model: Solution Structure by Nuclear Magnetic Resonance Spectroscopy and Effects on Growth Hormone Release and Gene Expression, International Conference in Structural Biology, The Chinese University of Hong Kong, Hong Kong, November 19-22, 2007 . 2007.

 

Sze K.H., Zhou H., Yang Y., He M., Jiang Y.H. and Wong A.O.L., Pituitary Adenyate Cyclase-Activating Polypeptide (PACPS) as a Growth Hormone (GH)-Releasing Factor in Grass Carp: II. Soution Structure of Brain-Specific PACAP by Nuclear Magnetic Respmamce Spectroscopy and Functiona Studies on GH Release and Gene Expression, Endocrinology . 2007, 148: 5042-5059.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Resonance Assignments of the 27kDa Active from of Maize Ribosone-Inactivating Protein (MOD) by NMR Spectroscopy, Poster Presentation on 16th Triennial Conferenc for the International Society of Magnetic Resonance, Kenting, Taiwan, October 14-19, 2007. P1-15.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., Solution Structure of a 28 kDa active Mutant of Maize Ribosome-Inactivating Protein (MOD) Studied by NMR Spectroscopy , Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, April 26-28, 2008. O-19.

 

Yang Y., Mak A.N.S., Shaw P.C. and Sze K.H., 1H, 13C and 15N Backbone and Side Chain Resonance Assignments of a 28 kDa Active Mutant of Maize Ribosome-inactivating Protein (MOD) , Biomolecular NMR Assignments . 2007, 12: 187-189.

 

Researcher : Yang Z



Project Title:

Blockade of BDNF-TrkB pathway as a novel anti-angiogenic therapy for HCC

Investigator(s):

Yang Z, Poon RTP

Department:

Surgery

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

05/2007

 

Abstract:

Hepatocellular carcinoma (HCC) is the second most common cause of cancer death in Hong Kong. As HCC is a highly vascularized solid tumor in which angiogenesis plays a crucial role, exploring the mechanisms of tumor angiogenesis may lead to a novel therapy for this cancer. A recent study by the investigators has identified brain-derived neurotrophic factor (BDNF) in serially collected serum samples during tumor development in a rat orthotopic HCC model (1). By immunohistochemical staining, it was found that BDNF was expressed not only in tumor cells, but also in endothelial cells in the tumor tissue, suggesting its potential role in tumor angiogenesis. In addition, others’ studies have shown that BDNF activation of its receptor, tyrosine kinase B (TrkB), promotes angiogenic properties and survival of endothelial cells (2,3), and upregulates the expression of vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors (4). Based on the above findings, we hypothesize that BDNF may play a crucial role in tumor angiogenesis of HCC, through its interaction with TrkB. Therefore, we propose the present study to explore the possible effects of BDNF on the angiogenic behaviors of endothelial cells by administration of exogenous BDNF to the endothelial cells in vitro. In addition, the therapeutic potential of blockade of BDNF-TrkB interaction as a novel anticancer approach will also be studied in vivo in a mouse HCC model.

 

 

Researcher : Yao H



List of Research Outputs

 

Chen Y., Lin M.C., Yao H., Wang H., Zhang A.Q., Yu J., Hui C.K., Lau G., He M.L., Sung J. and Kung H.F., Lentivirus-mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-regulation of Stathmin (Erratum in: Hepatology. 2007 Oct;46(4):1314), Hepatology. 2007, 46(1): 200-208.

 

Lai P.M., Yao H., Wong A.O.L. and Sze K.H., Structure and Functional Study of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), The Fifiennth Symposium on Chemistry Postgraduate Research in Hong Kong. The University of Hong Kong, Hong Kong, April 26, 2008.

 

Li Z., Yao H., Ma Y., Dong Q., Peng Y., Zheng B., Huang J., Chan C.Y., Lin M.C., Sung J.J., Yuen K.Y., Kung H.F. and He M.L., Inhibition of HBV gene expression and replication by stably expressed interferon-α1 via adeno-associated viral vectors, J Gene Med.. 2008, 10(6): 619-627.

 

Researcher : Yao H



List of Research Outputs

 

Chen Y., Lin M.C., Yao H., Wang H., Zhang A.Q., Yu J., Hui C.K., Lau G., He M.L., Sung J. and Kung H.F., Lentivirus-mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-regulation of Stathmin (Erratum in: Hepatology. 2007 Oct;46(4):1314), Hepatology. 2007, 46(1): 200-208.

 

Lai P.M., Yao H., Wong A.O.L. and Sze K.H., Structure and Functional Study of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), The Fifiennth Symposium on Chemistry Postgraduate Research in Hong Kong. The University of Hong Kong, Hong Kong, April 26, 2008.

 

Li Z., Yao H., Ma Y., Dong Q., Peng Y., Zheng B., Huang J., Chan C.Y., Lin M.C., Sung J.J., Yuen K.Y., Kung H.F. and He M.L., Inhibition of HBV gene expression and replication by stably expressed interferon-α1 via adeno-associated viral vectors, J Gene Med.. 2008, 10(6): 619-627.

 

Researcher : Yau HPM



List of Research Outputs

 

Yau H.P.M., Lin B.C. and Chan W.T., On-line Preconcentration for Chip-based Capillary Electrophoresis - Inductivey Coupled Plasma Atomic Emission Spectrometry Using Continuous-flow Fled-amplified Sample Stacking, Colloquim Spectroscopicum Internationale XXXV, Xiamen, China, September 23-27, 2007. 2007.

 

Yau H.P.M. and Chan W.T., Preconcentration of Trace Metal Ions Using Freshwater Algae for Inductively Coupled Plasma -- Mass Spectrometry , Abstract of Conference (Poster Presentation) Colloquium Spectroscopic um Internationale XXXV, Xiamen, China, September 23-27, 2007.

 

Researcher : Ye J



List of Research Outputs

 

Pang H.F., Ye J., Leung W.H., Chen G. and Cheung A.S.C., Experimental and Theoretical Studies of Diatomic Iridium Compounds , The 63rd International Symposium on Molecular Spectroscopy, Ohio State University, Ohio, U.S.A., June 16,. 2008, MF12.

 

Ye J., Electronic Spectroscopy of Transition Metal Monohalides (PhD Thesis) . 2007.

 

Ye J., Pang H.F., Wong M.Y., Leung W.H. and Cheung A.S.C., Laser Spectroscopy of Iridium Monoboride , The Journal of Chemical Phyics. 2008, 128: 154321-1 - 154321-6.

 

Researcher : Yeung CM



List of Research Outputs

 

Wang X.Y., Lai Z.S., Yeung C.M., Wang J.D., Deng W., Hang Y.J., Kung H.F., Jiang B. and Lin M.C., Establishment and Characterization of a New Cell Line Derived from Human Colorectal Laterally Spreading Tumor , World Journal of Gastroenterology. 2008, 14(8): 1204-1211.

 

Yeung C.M., Tan Y., Tam S., Lu L., Ko K.H., Yang P., Kung H.F. and Lin M.C., The Antidiabetic Effects of a Dry Powder of Dietary Vegetable and Fruit Mixtures in Diabetic db/db Mice, Biologics: Targets and Therapy. 2008, 2(3): 571-576.

 

Researcher : Yip PKT



List of Research Outputs

 

Lo K.Y., Yip P.K.T. and Yang D., Palladium(II) Catalyzed Oxidative Tandem Cyclizations of Alkenyl Amides, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes , 17th International Conference on Organic Synthesis (ICOS 17). 2008.

 

Yip P.K.T. and Yang D., Highly Diastereoselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, In: , The 15th Symposium on Chemistry Postgraduate Research in Hong Kong. 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The 15th Symposium on Chemistry Postgraduate Research in Hong Kong, April 26, 2008.

 

Yip P.K.T. and Yang D., Highly Diasteroselective Oxidative Cascade Cyclization Reactions Catalyzed by Palladium(II) Complexes, The IUPAC 17th International Conference on Organic Synthesis, Daejeon, Korea. June 15, 2008.

 

Researcher : Yip SK



List of Research Outputs

 

Lo H.S., Yip S.K., Zhu N. and Yam V.W.W., The First Example of a Pt...Pt Interectation in Platinium (II) Complexes Bearing Bulky Tri-tert-Butyl-2,2':6',2"- Terpyridine Pendants via Conformational Control of the Calix[4] Arene Moiety, , Dalton Transactions. 2007, 4386-4389.

 

Researcher : Yip WP



List of Research Outputs

 

Yip W.P., Yip W.P., Ho C.M., Zhu N., Lau T.C. and Che C.M., Homogeneous [RuIII(Me3tacn)Cl3]-Catalyzed Alkene cis-Dihydroxylation with Aqueous Hydrogen Peroxide , Chemistry - An Asian Journal. 2008, 70-77.

 

Researcher : Yu C



List of Research Outputs

 

Yu C., Chan H.Y., Wong M.C. and Yam V.W.W., Polyelectrolyte-induced Self-assembly of Positively Charged Alkynylplatinum(II) - Terpyridyl Complexes in Aqueous Media , Chemistry - A European Journal. 2008, 4577-4584.

 

Researcher : Yu SC



Project Title:

Functionalized organic semiconductors for organic thin film transistor (OTFT) development

Investigator(s):

Yu SC, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

The underlying theme of this project is to develop low-cost and practical organic semiconductors for organic thin film transistor (OTFT) applications. The principal objectives are: 1) to design stable and high performance organic semiconductors for use in OTFT technologies; 2) to develop a temperature-controlled OTFT fabrication system for improving device performance; 3) to study the structural effect of organic semiconductors on device performance. Importantly, the overall target is to transfer the technologies developed by this project to other material research programs under investigation at HKU, such as studies on new organic materials for molecular electronics.

 

List of Research Outputs

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., 234th ACS National Meeting. 2007, Poly-319.

 

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Functional nanostructured phosphorescent materials driven by weak closed-shell metal-metal interactions and metal-ligand coordination., Polymer Preprints (American Chemical Society, Divison of Polymer Chemistry). 2007, 48: 589 - 590.

 

Researcher : Yu WY



List of Research Outputs

 

Chiu J., Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, NanoBiotechnology World Conference, Nov. 13-14, 2007, Boston, MA, U. S. A.. 2007.

 

Researcher : Yuen AWH



List of Research Outputs

 

Deng Q., Xu H.W., Yuen A.W.H., Xu Z.J. and Che C.M., Ruthenium-Catalyzed One-Pot Carbenoid N-H Insertion Reactions and Diastereoselective Synthesis of Prolines , Organic Letters. 2008, 10: 1529-1532.

 

Researcher : Yuen WH



List of Research Outputs

 

Ho Y.S., Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on b-amyloid peptide neurotoxicity, Brain Research. 2007, 1158: 123-134.

 

Ho Y.S., Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Lycium barbarum as a potential drug to attenuate neurodegeneration in Alzheimer's disease, 2007 TWGHs Eddie Wang Symposium on Integrated Chinese and Western Medicine. 2007, 197.

 

Ho Y.S., Yu M.S., Yik S.Y., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Lycium barbarum protects neurons against neurodegeneration in Alzheimer's disease through multiple approaches, Third International Symposium on Healthy Aging: Improving the Health of an Aging Population, March 1-2, 2008, Hong Kong. 2008, 44 OP10.

 

Lai S.W., So K.F., Yuen W.H., So K.F., Zee S.S.Y. and Chang R.C.C., Antagonizing Beta-amyloid Peptide Neurotoxicity of the Anti-aging Fungus Ganoderma Lucidum, Brain Research . 2008, 1190: 215-224.

 

Yu M.S., Lai S.W., Ho Y.S., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Characterization of the Effects of Anti-aging Medicine Fructus Lycii on b-amyloid Peptide Neurotoxicity , International Journal of Molecular Medicine . 2007, 20: 261-268.

 

Yu M.S., So K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Neuroprotective polysaccharides from Nerium indicum rescue cultured neurons from beta-amyloid peptides-induced apoptosis via different mechanisms, Society for Neuroscience 2007. Program No. 169.8.

 

Researcher : Zeng Y



List of Research Outputs

 

Sun H., Ge R., Zeng Y., Wang H. and Huang J., Histidine-rich Protein, Hpn and Metallothionein: Are they Similar?, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Zeng Y., Zhang D. and Sun H., Overexpression and Characterization of a Histidine- and Glutamine-rich Protein, Hpn-like, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Researcher : Zhang D



List of Research Outputs

 

Zeng Y., Zhang D. and Sun H., Overexpression and Characterization of a Histidine- and Glutamine-rich Protein, Hpn-like, 13th International Conference on Biological Inorganic Chemistry (ICBIC-13), Vienna, Austria, July 15-20. 2007.

 

Researcher : Zhang Q



List of Research Outputs

 

Chan G.K.Y. and Zhang Q., Non-Equilibrium Molecular Dynamics Simulations of Yttria-Stabilized Zirconia Under an Alternating Electric Field, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A. November 4-9, 2007.

 

Zhang Q. and Chan G.K.Y., Alternate Current Nonequilibrium Molecular Dynamics Simulations Of yttria-stabilized Zirconia , Journal Of Physical Chemistry C. 2007, 11: 15832-15838.

 

Zhang Q., Molecular Simulation of Transport in Yitria-stabilized-zirconia and Silica Nanopore (PhD Thesis) . 2007.

 

Researcher : Zhang Q



List of Research Outputs

 

Chan G.K.Y. and Zhang Q., Non-Equilibrium Molecular Dynamics Simulations of Yttria-Stabilized Zirconia Under an Alternating Electric Field, Proceedings of 2007 American Institute of Chemical Engineers (AIChE) Annual Meeting, Salt Lake City, Utah, U.S.A. November 4-9, 2007.

 

Zhang Q. and Chan G.K.Y., Alternate Current Nonequilibrium Molecular Dynamics Simulations Of yttria-stabilized Zirconia , Journal Of Physical Chemistry C. 2007, 11: 15832-15838.

 

Zhang Q., Molecular Simulation of Transport in Yitria-stabilized-zirconia and Silica Nanopore (PhD Thesis) . 2007.

 

Researcher : Zhao W



List of Research Outputs

 

Zhao W., O W.S. and Fung Y.S., Quantitation of Mitochondria Separated by Capillary Electrophoresis , 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:50, pp 5:141.

 

Researcher : Zhao Y



Project Title:

Computer simulation of carbon nanotube bearings and nanoscopic equipartition processes

Investigator(s):

Zhao Y

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2005

 

Abstract:

To explore various mechanical properties of CNT-based bearings and rotators, to optimize their nanomechanic operating conditions, to help design new, CNT-based NEMS components.

 

Project Title:

Ultrafast Relaxation Dynamics of Photo-Excited States

Investigator(s):

Zhao Y, Dai J

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

The advent of ultrafast femtosecond laser spectroscopy brings about intense research interest in relaxation dynamics of photo-excited states in liquids and solids. It is now commonly accepted that dephasing and relaxation time scales in condensed matter are approximately picoseconds, and in semiconductor dots and wells, tens of picoseconds. Newly-arrived technological capabilities to control femtosecond pulse durations and down-to-one-hertz bandwidth resolutions provide novel probes on vibrational dynamics and excitation relaxation. For example, progress in femtosecond spectroscopic techniques has made it possible to observe a coherent phonon wave packet oscillating along an adiabatic potential surface associated with a self-trapped exciton in a crystal with strong exciton-phonon interactions. [1-2] However, despite a flood of new, fascinating measurements, a microscopic theory of nonlinear optical response in general and photo-generated excitation relaxation in particular, essential to interpret those experimental findings, remains largely elusive. It is the purpose of the proposed project to formulate time-dependent polaronic wave functions that facilitate microscopic modelling of photo-generated excitation relaxation and realistic computation of various third-order optical response functions, and help to bring about a satisfactory comparison between theory and experiment. To that end, a hierarchy of time-dependent variational wave functions with increasing sophistication will be devised to accurately describe femtosecond polaron dynamics for various circumstances, and the Dirac-Frenkel variational principle will be employed to optimize these trial states. Based on these wave functions, nonlinear optical response functions such as time-resolved spontaneous emission spectra will be then calculated, and results will be applied to interpret a large variety of available experimental data. Quasi-one-dimensional molecules, such as polydiacetylene, beta-carotenoid and halogen bridged mixed valent platinum compounds, have recently emerged as promising candidates for ultrafast optical devices with enhanced nonlinearities. In one-dimensional systems, polaronic self-trapping is believed to take place without a potential barrier, and the time scale for barrier-free trapping is expected to be extremely small. For simplicity, the proposed project will start with the one-dimensional Holstein model [4-7] that can realistically describe polaron dynamics in these quasi-one-dimensional molecules. The formulation to be developed here, however, is expected to be readily extendable to higher dimensions. Polaron dynamics in the simultaneous presence of diagonal and off-diagonal exciton-phonon coupling will also be considered. The former is defined as a nontrivial dependence of the exciton site energies on lattice coordinates, and the latter, as a nontrivial dependence of the exciton transfer integral on lattice coordinates. Most polaron models in the literature have chosen to neglect the off-diagonal exciton-phonon coupling owing to difficulties in obtaining reliable solutions in its presence. The time-dependent polaronic wave functions to be developed here is expected to be well-suited to simulate polaron dynamics in the presence of both types of exciton-phonon interactions.References[1] S. Tomimoto, H. Nansei, S. Saito, T. Suemoto, J. Takeda, and S. Kurita, Phys. Rev. Lett. 81, 417 (1998).[2] S.L. Dexheimer, A.D. van Pelt, J.A. Brozik, and B.I. Swanson, Phys. Rev. Lett. 84, 4425 (2000).[3] P.A.M. Dirac, Proc. Cambridge, Phil. Soc. 26, 376 (1930); J. Frenkel, Wave Mechanics (Oxford University Press, Oxford, 1934).[4] T. Holstein, Ann. Phys. (N.Y.) 8, 325 (1959). [5] T. Holstein, Ann. Phys. (N.Y.) 8, 343 (1959).[6] Y. Toyozawa, Prog. Theor. Phys. 26, 29 (1961).[7] Y. Zhao, D.W. Brown, and K. Lindenberg, J. Chem. Phys. 107, 3159 (1997).

 

Project Title:

Dynamics of nano bearings

Investigator(s):

Zhao Y, Chen G

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

Miniaturization of electronic and mechanical devices over the past century has brought immeasurable impact on human lives. Commercial microelectromechanical systems have reached the micrometer size scale, and bona fide molecular-scale apparatuses loom on the horizon setting the stage for upcoming integrated nanoelectromechanics. One essential component of nanoelectromechanical systems (NEMS)1 that has been successfully fabricated is carbon nanotube (CNT) based bearings, rotators and their preceding cousin, torsional oscillators.2,3 Such mechanical nanodevices made of bended graphite sheets was first conceived by Drexler in his book4 of a futuristic nanoworld in which submicrometer-scale machines move atoms and molecules and create novel, artificial structures. Competing devices such as diamondoid bearings may be stiffer mechanical components, but their possible fabrication awaits further synthetic innovations. Essential in conventional macroscopic machines, bearings are expected to have at least equal importance in molecular machines. Conditions that must be met to insure adequate performance of nano bearings therefore demand a careful examination. However, despite unlimited technological prospects of NEMS, performance, wear and frictional properties of fundamental components of NEMS remain largely unknown. This is especially true for CNT-based bearings which have received very little theoretical attention. The proposed project is aimed precisely to address some of the pressing issues via molecular dynamics simulation. Our objectives are: (1) To explore mechanical properties of CNT-based bearings, rotators and torsional devices in general, and bearing frictional properties in particular; (2) To optimize nanomechanic operating conditions of CNT-based bearings such as bearing working temperatures and laser driving fields, and to improve their load-bearing characteristics (especially under time-dependent or multidimensional transverse loads); (3) To help design new, CNT-based NEMS components such as gears and manipulating devices that use nano bearings. (4) Of equal importance is to explore nanoscopic implications to fundamental hypotheses in thermodynamics and statistical mechanics. For instance, the second law of thermodynamics forbids entropy reduction in an isolated, macroscopic system. However, from our experience with CNT-based gigahertz oscillators 5, an NEMS device may likely violate the second law for brief periods of time despite that the probability of such violations is expected to decrease exponentially with the amount of entropy reduction. Molecular Dynamics simulation of CNT-based bearings will shed more light on possible nanoscopic second-law violations and other fascinating, unresolved subjects in nonequilibrium statistical mechanics. Furthermore, CNT-based bearings are in fact three-dimensional constructs of coupled Lennard-Jones oscillators that bear close resemblance to the Fermi-Pasta-Ulam model widely used for equipartition studies, and can therefore serve as a test bed for ergodicity on complex energy surfaces. Simplified analytical models will be constructed to compare with various energy thresholds derived from simulations that separate characteristic regimes, such as a quasi-Kolmogorov-Arnold-Moser regime of minimal dissipative effects and an ergodic-type regime with significantly higher mechanical friction.

 

List of Research Outputs

 

Hu L., Zhao Y., Wang F., Chen G., Ma C., Kwok W.M. and Phillips D.L., Are Adenine Strands Helical H-Aggregates?, Journal of Physical Chemistry B. 2007, 111: 11812-11816.

 

Researcher : Zhu D



List of Research Outputs

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-Methyl-3-Ethylimidazolium Chloride / Urea System, Proceedings of 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007. TThB1, pp109.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-methyl-3-ethylimidazolium Chloride / Urea System , International Symposium of Task-specific Ionic Liquids, Keio University, Yokohama, Japan, August 3-4, 2007. 2007.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin Alloys from Room Temperature Ionic Liquid Based on the 1-methyl-3-ethylimidazolium Chloride / Urea System , 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007. 2007.

 

Fung Y.S. and Zhu D., Electrodeposition of Tin and its Alloys from Room Temperature Ionic Liquid Based on the 1-Methyl-3-Ethylimidazolium Chloride Systems , Proceedings, International Symposium on Task-Specific Ionic Liquids, Keio University, Yokohama, Japan, August 3-4, 2007. pp17.

 

Sun H., Mo Z., Choy T.S.J., Zhu D. and Fung Y.S., Piezoelectric Quartz Crystall Sensor for Sensing Taste-causing Compounds in Food , Sensors and Actuators B Chemical. 2008, 131: 148-158.

 

Zhu D. and Fung Y.S., Electrodeposition of Tin Alloy Electrode in Ternary Ionic Liquid (MEIC-urea SnC12) for Lithium Battery Application , Proceedings 2nd International Congress on Ionic Liquids (COIL-2), Yokohama, Japan, August 5-10, 2007 . 2007, 1P07-077, pp200.

 

Zhu D., Sun H. and Fung Y.S., Electrodeposition of Tin from the 1-Methyl-3-Ethyllimidazolium Chloride/AlCl3SnCl2 Room Temperature Molten Salts , Electrochemical Society Transactions . 2007, 3: 239-248.

 

Researcher : Zhu M



List of Research Outputs

 

Zhu M., Syntheses, Characterization and Photophyscial Properties of Platinum(II) and Gold(I) Complexes Containing Ortho- and Meta- Oligo (Phenyleneethynylene) Lignds (PhD Thesis) . 2008.

 

Researcher : Zhu N



List of Research Outputs

 

Chan C.L., Cheung K.L., Lam S.W.H., Cheng C.C., Zhu N., Choi W.K.S. and Yam V.W.W., Luminescent Molecular Copper(I) Alkynyl Open Cubes: Synthesis, Structural Characterization, Electronic Structure, Photophysics, and Photochemistry, Chemistry - An Asian Journal. Weinheim, Wiley VCH, 2007, 1: 273-286.

 

Che C.M., Kwok C.C., Lai S.W., Finkenzeller W., Rausch A., Yersin H. and Zhu N., Synthesis, Photophysical Properties and OLED Applications of Luminescent Platinum(II) Schiff Base Emitters, The First Asian Conference on Coordination Chemistry, Okazaki, Japan, 29 July - 2 Aug. 2007.

 

Huang J.S., Xie J., Kui C.F., Fang G.S., Zhu N. and Che C.M., Self-assembly of a Cyclic Metalladecapyridine from the Reaction of 2,6-Bis(bis(2-Pyridyl)Methoxymethane) Pyridine with Silver(I) , Inorganic Chemistry. 2008, 47: 5727-5735.

 

Lai S.W., Chan K.W.Q., Zhu N. and Che C.M., cis-Dicyanoosmium(II) Diimine Complexes Bearing Phosphine or Sulfoxide Ligands: Spectroscopic and Luminescent Studies, Inorganic Chemistry. Washington, D.C., American Chemical Society, 2007, 46: 11003-11016.

 

Li M., Chen Z., Zhu N., Yam V.W.W. and Zu Y., Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cations Binding , Inorganic Chemistry. 2008, 1218-1223.

 

Li M., Ko C.C., Duan G., Zhu N. and Yam V.W.W., Functionalized Rhenium(I) Complexes with Crown Ether Pendants Derived from 1,10-Phenanthroine: Selective Sensing for Meta Ions , Organometallics. 2007, 6091-6098.

 

Lo H.S., Yip S.K., Zhu N. and Yam V.W.W., The First Example of a Pt...Pt Interectation in Platinium (II) Complexes Bearing Bulky Tri-tert-Butyl-2,2':6',2"- Terpyridine Pendants via Conformational Control of the Calix[4] Arene Moiety, , Dalton Transactions. 2007, 4386-4389.

 

Lo K.K.W., Sze K.S., Tsang K.H.T. and Zhu N., Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteins , Organometallics. 2007, 3440-3447.

 

Lo K.K.W., Tsang K.H.K., Sze K.S., Chung C.K., Lee T.K.M., Zhang K.Y., Hui W.K., Li C.K., Lau J.S.Y., Ng D.C.M. and Zhu N., Non-covalent Binding of Luminescent Transition Metal Polypyridine Complexes to Avidin, Iodole-binding Proteins and Estrogen Receptors , Coordination Chemistry Reviews. 2007, 2292-2310.

 

Lu W., Law Y.C., Han J., Chui S.Y., Ma D.L., Zhu N. and Che C.M., A Dicationic Organoplatinum(II) Complex Containing a Bridging 2,5-Bis-(4-ethynylphenyl)-[1,3,4]oxadiazole Ligand Behaves as a Phosphorescent Gelator for Organic Solvents, In: W. Lu, Y. C. Law, J. Han, S. S. Y. Chui, D. L. Ma, N. Zhu, C. M. Che, Chemistry - An Asian Journal. 2007, 3: 59-69.

 

Pan J., Yang M., Gao Q., Zhu N. and Yang D., Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds , Synthesis . 2007, 2539-2544.

 

Tam Y.Y., Lam S.W.H., Wong M.C., Zhu N. and Yam V.W.W., Luminescent Alkynylplatinum(II) Complexes of 2,6-Bis (N-alkylbenzimidazol-2'-yl) Pyridine-Type Ligands with Ready Tunability of the Nature of the Emissive States by Solvent and Electronic Property Modulation , Chemistry - A European Journal. 2008, 14: 4562-4576.

 

Yang N., Tanner J.A., Wang Z., Huang J., Zheng B., Zhu N. and Sun H., Inhibition of SARS coronavirus helicase by bismuth complexes, Chemical Communications. 2007, 4413-4415.

 

Yip W.P., Yip W.P., Ho C.M., Zhu N., Lau T.C. and Che C.M., Homogeneous [RuIII(Me3tacn)Cl3]-Catalyzed Alkene cis-Dihydroxylation with Aqueous Hydrogen Peroxide , Chemistry - An Asian Journal. 2008, 70-77.

 

Zhang J., Chu W.K., Zhu N. and Yam V.W.W., Synthesis, Characterizationl, Langmuir - Blodgett Film-Forming Property, and Second-Order Nonlinear Optical Study of Rhenium(I) and Ruthenium(II) Diimine Complexes , Organometallics. 2007, 5423-5429.

 

Researcher : Zu Y



Project Title:

Development of a New Class of Chemosensor Based on the Electrogenerated Chemiluminescence of Metal Complex with Crown Ether Moiety

Investigator(s):

Zu Y, Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To design and synthesize a series of luminescent metal complexes with crown ether moieties; to investigate the photophysical, electrochemical and ECL properties of the new compounds and their responses upon binding with various metal cations.

 

Project Title:

Study on a Novel Type of Electrogenerated Chemiluminescence: Characterization and Applications in Bioanalysis

Investigator(s):

Yam VWW

Department:

Chemistry

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2005

 

Abstract:

The main objective of this project is to investigate the characteristics of a new type of ECL, i.e. low-oxidation-potential (LOP) ECL based on metal complex systems, and explore the strategies of utilizing the LOP ECL signal in bioanalysis.

 

List of Research Outputs

 

Li M., Chen Z., Zhu N., Yam V.W.W. and Zu Y., Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cations Binding , Inorganic Chemistry. 2008, 1218-1223.

 

Li M., Chen Z., Yam V.W.W. and Zu Y., Multifunctional Ruthenium (II) Polypyridine Complex-Based Core-Shell Magnetic Silica Nanocomposites: Magnetism, Luminescence, and Electrochemiluminescence , ACS Nano. 2008, 2: 905-912.

 

Lu C., Zu Y. and Yam V.W.W., Nonionic Surfactant-capped Gold Nanoparticles as Postcolumn Reagents for High-performance Liquid Chromatography Assay of Low-molecular-mass Biothiols , Journal of Chromatography A. 2007, 1163: 328-332.

 

Researcher : Zuo P



List of Research Outputs

 

Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P., An H. and Phillips D.L., Time-Resolved Studies of Phototrigger Compounds , Invited Lecture and Abstract of the 3rd International Conference on Optoelectronics and Spectroscopy of Nanostructured Thin Films and Materials (ICOSFM 2007), Beijing, P.R. China, October 15-19, 2007.

 

Phillips D.L., Ma C., Kwok W.M., Du Y., Chan W.S., Zuo P. and An H., Time-Resolved Spectroscopic Investigation of the Reactions and Mechanisms of Phototrigger Compounds , Invited Lecture and Abstract of the 5th Singapore International Chemistry Conference (SICC-5), Singaopore, December 16-19, 2007.



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