DEPT OF MEDICINE



Researcher : Au KW
List of Research Outputs

Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Au WS
List of Research Outputs

Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.


Researcher : Au WY
List of Research Outputs

Au W.Y., Lee V., Lau C.W., Yau J., Chan D., Chan E.Y.T., Cheung W.W.W., Ha S.Y., Kho B., Lee C.Y., Li R.C.H., Li C.K., Lin S.Y., Ling A.S.C., Mak V., Sun L., Wong K.H.F., Wong R. and Yuen H.L., A synopsis of current care of thalassaemia major patients in Hong Kong, Hong Kong Medical Journal. 2011, 17(4): 261-266.
Au W.Y. and Chan S.C., Association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and fatal outcome of hepatitis E infection in middle-aged men (Letter to the Editor), Singapore Medical Journal. 2012, 53(2): 148-149.
Au W.Y., Wai-Hung L., Wong K.Y. and Choi W.L., Concomitant plasmacytoma and B cell lymphoma with discordant light chain expression but clonal identity, Ann Hematol. 2012, 91: 1649-51.
Au W.Y., Li C.K., Lee V., Yuen H.L., Yau J., Chan G.C.F., Ha S.Y. and Kwong Y.L., Oral arsenic trioxide for relapsed acute promyelocytic leukemia in pediatric patients, Pediatric Blood Cancer. 2012, 58(4): 630-632.
Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chan V., Song K., Mang O., Ip D.K.M. and Au W.Y., Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year survey, Leukemia & Lymphoma. 2011, 52(12): 2316-2320.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Cheung Y.F., Chan G.C.F., Au W.Y., Lam W.W.M., Cheung W.W.W., Ho Y.C., Wong S.J. and Ha S.Y., Left ventricular torsional mechanics remains impaired in patients with beta-thalassaemia major despite bone marrow transplanation, American Heart Association Scientifice Sessions 2011, Orlando, Florida, USA 2011.
Küçük C., Iqbal J., Hu X., Gaulard P., De Leval L., Srivastava G., Au W.Y., McKeithan T.W. and Chan W.C., PRDM1 is a tumor suppressor gene in natural killer cell malignancies, Proc Natl Acad Sci U S A . 2011, 108(50): 20119-24.
Love C.L., Jima D., Zhang J., Grubor V., Miles R.R., Dunphy C.H., Richards K.L., Choi W.L., Au W.Y., Srivastava G., Chadburn A., Gordon L.I., Evens A.M., Hsi E.D., Czader M., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Sunay S., Flowers C.R., Naresh K., Thompson M.A., Gill J. and Dave S.S., Whole genome and exome sequencing reveals the genetic landscape of Burkitt lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Miezcowski P., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D.D., Luftig M., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B. and Dave S.S., The genetic landscape of immune-competent and HIV lymphoma, 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). 2012.


Researcher : Bow CHY
List of Research Outputs

Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.


Researcher : Bu L
Project Title:Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):Bu L, Li RA
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Lui O.L.K., Bu L., Li R.A. and Chan C.W.Y., Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives. , Birth Defects Res C Embryo Today. 2012, 96.


Researcher : Chan AOO
List of Research Outputs

Cheng C., Chan T.N., Chio J.H., Chan P., Chan A.O.O. and Hui W.M., Being active or flexible?: Role of control coping on quality of life among patients with gastrointestinal cancer. Psycho-Oncology, 21, 211-218. , 2012.
Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Cho C.H. and Yuen R.M.F., Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1β activation of nitric oxide production in gastric cancer cells., Cancer. 2012.


Researcher : Chan CW
List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.


Researcher : Chan DTM
Project Title:Serum immunoglobulin levels and resident renal cell-binding in patients with severe lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2009
Completion Date:10/2011


Project Title:The role of annexin II in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Characterization of renal proximal tubular epithelial cell antigens that mediate anti-dsDNA antibody binding and internalization, and their pathogenic role in lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:The role of fibronectin in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2011


Project Title:2nd International Conference on Immune Tolerance 4-Methylumbelliferone suppresses hyaluronan synthesis in NZB/W F1 mice and reduces immune-mediated renal inflammation
Investigator(s):Chan DTM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:10/2011


Project Title:The role of hyaluronan and effect of 4-methylumbelliferone in tubulo-interstitial fibrosis in lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., 4-methylumbelliferone suppresses hyaluronan synthesis in NZB/W F1 mice and reduces immune-mediated renal inflammation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Suppression of hyaluronan synthesis with 4-methylumbelliferone in NZB/W F1 mice is associated with reduced renal inflammation and renal function improvement, Journal of the American Society of Nephrology. 2011.
Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.
Chong Y.B., Yap Y.H.D., Tang S.O.C. and Chan D.T.M., Dyslipidemia in patients with lupus nephritis., Nephrology (Carlton). 2011, 16: 511-7.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Binding of serum IgG to human mesangial cells and its correlation with disease activity in patients with lupus nephritis, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yap Y.H.D., Yu X., Chen X.M., Lu F., Chen N., Li X.W., Tang C.S. and Chan D.T.M., Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome, Nephrology (Carlton). 2012, 17: 352-7.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Serum IgG binding to human mesangial cells in patients with lupus nephritis and its correlation with disease activity, Journal of the American Society of Nephrology. 2011.
Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.
Yung S.S.Y. and Chan D.T.M., Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis : getting to know the unknown, Clinical and Developmental Immunology. 2012.
Yung S.S.Y., Ng Y.C.C. and Chan D.T.M., Binding of anti-dsDNA antibodies to human proximal tubular epithelial cells induces IL-6 and MCP-1 secretion through MAPK phosphorylation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Yung S.S.Y., Ng K.F., Yim A.S.Y., Ma M., Lui S.L. and Chan D.T.M., Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate, Journal of the American Society of Nephrology. 2011.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of hyaluronan synthesis with 4-methylumbelliferone in NZBWF1/J mice is associated with improved renal function and reduced renal inflammation, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yung S.S.Y. and Chan D.T.M., Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells, Mediators of Inflammation. 2012.
Yung S.S.Y. and Chan D.T.M., Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan, Journal of Biomedicine and Biotechnology. 2011.


Researcher : Chan HHL
Project Title:The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):Chan HHL, Lam LK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2000


Project Title:The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):Chan HHL, Wei WI
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:11/2001




Researcher : Chan JCK
Project Title:Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):Chan JCK, Lam WK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:07/1995




Researcher : Chan K
List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.


Researcher : Chan KH
Project Title:Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:01/2008


Project Title:Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):Chan KH, Ho SL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:03/2008


Project Title:The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:04/2009


Project Title:Study of pathophysiological effect of anti-aquaporin-4 autoantibodies in neuromyelitis optica by passive transfer into mice
Investigator(s):Chan KH, Ho SL, Ho WL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009
Completion Date:09/2011


Project Title:Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010


Project Title:Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2011


List of Research Outputs

Chan K.H., A Hong Kong Perspective on the Treatment of Multiple Sclerosis and Neuromyelitis Optica, Asian Multiple Sclerosis Regional Medical Conference: Evolving Patient Treatment and Care in Asia, 2012, Hong Kong. 2012.
Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Chan K.H., Autoantibodies in autoimmune myasthenia gravis, Bimonthly Meeting of the Paediatric Neurology Association of Hong Kong. 2012.
Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Chan K.H. and Chang R.C.C., Co-chairman of Organizing Committee of 7th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Faculty Teaching Medal 2011, LKS Faculty of Medicine, The University of Hong Kong. 2011.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Chan K.H., Invited Chairmanship at plenary section of the Medical Research Conference, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Invited Speaker & Discussant, The Guthy-Jackson Charitable Foundation’s fourth NMO Roundtable Conference. Los Angeles, USA, 2011.
Chan K.H., Member of Organizing Committee , Alzheimer's Disease Conference: From Public Health to Therapeutic Insights. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee of 17th Hong Kong Medical Forum , University Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee of the 15th Hong Kong Medical Forum , University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee, 17th Medical Research Conference, University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Multiple Sclerosis, Sun Post. 2012.
Chan K.H., Multiple sclerosis affects cognitive functions. (in Chinese) , Health Plus. 2012, 135: 26.
Chan K.H., Multiple sclerosis affects patients lifelong. (in Chinese) , Health Plus. 2012, 142: 37.
Chan K.H., Natalizumab Case Sharing, “Multiple Sclerosis Update”, Hong Kong, organized by the Hong Kong Neurological Society. 2012.
Chan K.H., The practical evidence-based approach in stroke treatment, Sunday Symposium (CME for medical doctors) of the Society of Physicians of Hong Kong. Hong Kong, 2012.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.
Pong V., Chan K.H., Chong B.H., Lui W.M., Leung G.K.K., Tse H.F., Pu J.K.S. and Siu D.C.W., Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage. , Cerebellum. 2012.
Tse C.T., Chan K.H., Cheung R.T.F. and Ho S.L., Guillain-Barre syndrome associated with acute hepatitis E infection, Journal of Clinical Neuroscience. 2011, 19: 607-608.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Chan KH
List of Research Outputs

Chan K.H., A Hong Kong Perspective on the Treatment of Multiple Sclerosis and Neuromyelitis Optica, Asian Multiple Sclerosis Regional Medical Conference: Evolving Patient Treatment and Care in Asia, 2012, Hong Kong. 2012.
Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Chan K.H., Autoantibodies in autoimmune myasthenia gravis, Bimonthly Meeting of the Paediatric Neurology Association of Hong Kong. 2012.
Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Chan K.H. and Chang R.C.C., Co-chairman of Organizing Committee of 7th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Faculty Teaching Medal 2011, LKS Faculty of Medicine, The University of Hong Kong. 2011.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Chan K.H., Invited Chairmanship at plenary section of the Medical Research Conference, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Invited Speaker & Discussant, The Guthy-Jackson Charitable Foundation’s fourth NMO Roundtable Conference. Los Angeles, USA, 2011.
Chan K.H., Member of Organizing Committee , Alzheimer's Disease Conference: From Public Health to Therapeutic Insights. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee of 17th Hong Kong Medical Forum , University Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee of the 15th Hong Kong Medical Forum , University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Member of Organizing Committee, 17th Medical Research Conference, University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. Hong Kong, 2012.
Chan K.H., Multiple Sclerosis, Sun Post. 2012.
Chan K.H., Multiple sclerosis affects cognitive functions. (in Chinese) , Health Plus. 2012, 135: 26.
Chan K.H., Multiple sclerosis affects patients lifelong. (in Chinese) , Health Plus. 2012, 142: 37.
Chan K.H., Natalizumab Case Sharing, “Multiple Sclerosis Update”, Hong Kong, organized by the Hong Kong Neurological Society. 2012.
Chan K.H., The practical evidence-based approach in stroke treatment, Sunday Symposium (CME for medical doctors) of the Society of Physicians of Hong Kong. Hong Kong, 2012.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.
Pong V., Chan K.H., Chong B.H., Lui W.M., Leung G.K.K., Tse H.F., Pu J.K.S. and Siu D.C.W., Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage. , Cerebellum. 2012.
Tse C.T., Chan K.H., Cheung R.T.F. and Ho S.L., Guillain-Barre syndrome associated with acute hepatitis E infection, Journal of Clinical Neuroscience. 2011, 19: 607-608.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Chan KK
List of Research Outputs

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of Sox9 in human neural stem cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.


Researcher : Chan MMW
Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2001


Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004


List of Research Outputs

Lam C.L.D., Fong D.Y.T., Yu W.C., Ko F.W., Lau A.C., Chan J.W., Choo K.L., Mok T.Y., Tam C.Y., Ip M.S.M. and Chan M.M.W., FEV3, FEV6 and their derivatives for detecting airflow obstruction in adult Chinese, Int J Tuberc Lung Dis. 2012, 16 (5): 681 - 686.
Lau K.W., Chan M.M.W., Yip B.H.K., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 31.
Lau K.W., Chan M.M.W., Yip B.H., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, PLoS One. 2012, 7(2): e31617.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.


Researcher : Chan OOC
List of Research Outputs

Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Binding of serum IgG to human mesangial cells and its correlation with disease activity in patients with lupus nephritis, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Serum IgG binding to human mesangial cells in patients with lupus nephritis and its correlation with disease activity, Journal of the American Society of Nephrology. 2011.


Researcher : Chan TK
List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.
Meyer C., Kowarz E., Yip S.F., Wan T.S.K., Chan T.K., Dingermann T., Chan L.C. and Marschalek R., A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia, Cancer Genetics . 2011, 204: 430-438.


Researcher : Chan VNY
Project Title:Hepatitis B virus array for genotyping and mutation detection
Investigator(s):Chan VNY, Lai CL, Chan K, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2006


List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.
Chan V.N.Y. and Wong V.C.N., Spinal muscular atrophy in Chinese, The European Neurological Journal. 2012.
Stephens A.D., Angastiniotis M., Baysal E., Chan V.N.Y., Davis B., Fucharoen S., Giordano P.C., Hoyer J.D., Mosca A., Wild B. and International Council for The Standardisation of Haematology (.I.C.S.H.)., ICSH recommendations for the measurement of Haemoglobin F, International Journal of Laboratory Hematology. 2012, 34: 14-20.
Stephens A.D., Angastiniotis M., Baysal E., Chan V.N.Y., Fucharoen S., Giordano P.C., Hoyer J.D., Mosca A., Wild B. and International Council for the Standardisation of Haematology (.I.C.S.H.)., ICSH recommendations for the measurement of haemoglobin A2, International Journal of Laboratory Hematology. 2012, 34: 1-13.


Researcher : Chan VSF
Project Title:Development of a humanized mouse systemic lupus erythematosus model for studying disease pathogenesis and evaluation of therapeutic treatment efficacy
Investigator(s):Chan VSF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Functional characterization of the novel C-type lectin-like receptor CLEC16A and its expression association in systemic lupus erythematosus
Investigator(s):Chan VSF, Lau WCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Molecular profiling of pathogenic dendritic cells development in systemic lupus erythematosus
Investigator(s):Chan VSF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Chan V.S.F., Nie Y.J., Shen N., Yan S., Mok T.M.Y. and Lau W.C.S., Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus, Autoimmunity Reviews. 2012, Epub ahead of print.
Chan V.S.F., Innate immunity, dendritic cells and SLE., Autoimmunity Congress Asia. 2011.
Chan V.S.F., SLE: Insights from animal models., Ten Topics Lupus Asia 2011. 2011.


Researcher : Chan WM
List of Research Outputs

Chan W.M., Lau L.S., Kwok K.M., Law W.L., Ho J.C.M., Chu K.M. and Poon R.T.P., A randomized, double-blind, placebo-controlled, ascending dose infusion trial of the pharmacokinetics of recombinant human Gelsolin in patients with decreased natural Gelsolin levels, American Thoracic Society International Conference, Denver, U.S.A., 13 - 18 May 2011. American Journal of Respiratory and Critical Care Medicine. 2011, 183: A5601.


Researcher : Chan YC
List of Research Outputs

Chan Y.C., Leung F.P., Tian X.Y., Yung L.M., Lau C.W., Chen Z.Y., Yao X., Laher I. and Huang Y., Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet., Pharmacol Res. . 2012, 65(2): 182-8.
Chan Y.C., Travel Award , International Society for Stem Cell Research (ISSCR) 10th Annual Meeting (Yokohama, Japan). 2012.
Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Li W., Wang X., Fan W., Zhao P., Chan Y.C., Chen S., Zhang S., Guo X., Zhang Y., Li Y., Cai J., Qin D., Li X., Yang J., Peng T., Zychlinski D., Hoffmann D., Zhang R., Deng K., Ng K.M., Menten B., Zhong M., Wu J., LI Z., Chen Y., Schambach A., Tse H.F., Pei D. and Esteban M.A., Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes., Hum Mol Genet. 2012, 21(1): 32-45.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.
Tang S., Lecina M., Chan Y.C., Tse H.F., Reuveny S. and Oh S.K.W., Increasing cardiomyogenesis of hESC by enhancing cell survival using an improved serum free media., Stem Cell Research (In Preparation). 2012.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Chan YY
List of Research Outputs

Lai K.N., Lam M.F., Leung J.C.K., Chan Y.Y., Lam C.W., Chan I.H., Chan H.W., Li C.S., Wong S.S., Ho Y.W., CHEUK A., Tang M.K. and Tang S.C.W., A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products, Peritoneal Dialysis International. 2011, 32(3): 280-91.
Leung J.C.K., Chan Y.Y., Tang S.C.W., Lam M.F., Chow C.W., Lim A.I. and Lai K.N., Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone, Journal of Translational Medicine. 2011, 9: 169-183.
Leung J.C.K., Chan Y.Y., Lam M.F., Tang S.C.W., Chow C.W., Lim A.I. and Lai K.N., The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid, Nephrology Dialysis Transplantation ePub. 2012.
Lim A.I., Chan Y.Y., Lai K.N., Tang S.C.W., Chow C.W., Lam M.F. and Leung J.C.K., Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells, International Journal of Biochemistry and Cell Biology . 2012, 44: 1040-1050.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.


Researcher : Chang SKR
List of Research Outputs

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.


Researcher : Chau CH
List of Research Outputs

Lee C.H., Yuen M.M.A., Chow W.S., Tso A.W.K., Yeung C.K., Chan J.C.Y., Chau C.H. and Lam K.S.L., A man with a blistering eruption and tuberculosis, BMJ. 2012, 344: d8351.


Researcher : Chau KM
List of Research Outputs

Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., 4-methylumbelliferone suppresses hyaluronan synthesis in NZB/W F1 mice and reduces immune-mediated renal inflammation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Suppression of hyaluronan synthesis with 4-methylumbelliferone in NZB/W F1 mice is associated with reduced renal inflammation and renal function improvement, Journal of the American Society of Nephrology. 2011.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of hyaluronan synthesis with 4-methylumbelliferone in NZBWF1/J mice is associated with improved renal function and reduced renal inflammation, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.


Researcher : Che H
List of Research Outputs

Che H. and Li G.R., Effects of functional transient receptor potential channels on adipogenesis and proliferation in human preadipocytes, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 24.
Che H., Sun H. and Li G.R., Functional transient receptor potential channels in human cardiac c-kit cells, Hong Kong - Taiwan Physiology Symposium, June. 2012, 51.
Chen J., Liu W., Che H., Liu J., Sun H. and Li G.R., Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. , Br J Pharmacol. . 2012, 166(3): 1140-1150.


Researcher : Chen C
Project Title:Potential roles of fibroblast growth factor 21 (FGF21) in the regulation of thermogenesis by thyroid hormone in brown adipose tissue
Investigator(s):Chen C, Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2012


List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Chen C., Li P., Madhavan R. and Peng H.B., The function of p120 Catenin in Filopodial Growth and Synaptic Vesicle Clustering in Neurons, Molecular Biology of Cell. 2012.
Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Li P.P., Chen C., Lee C.W., Madhavan R. and Peng H.B., Axonal filopodial asymmetry induced by synaptic target, Mol Biol Cell. 2011, 22(14): 2480-90.
Xiao Y., Xu A., Law S.C., Chen C., Li H., Li X., Yang L., Liu S., Zhou Z. and Lam K.S.L., Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes, J Clin Endocrinol Metab. 2012, 97(1): E54-8.


Researcher : Chen J
List of Research Outputs

Chen J., Liu W., Che H., Liu J., Sun H. and Li G.R., Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. , Br J Pharmacol. . 2012, 166(3): 1140-1150.


Researcher : Chen WH
Project Title:Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/2001


Project Title:A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003




Researcher : Cheng KY
Project Title:APPL1 as a novel adaptor protein regulating insulin sensitivity and glucose homeostasis
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:08/2010
Completion Date:02/2012


Project Title:EMBO Ubiquitin Meeting 2011 The E3 ligase TRAF6 regulates the insulin-sensitizing actions of the adaptor protein APPL1 through ubiquitination
Investigator(s):Cheng KY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011
Completion Date:09/2011


List of Research Outputs

Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Cheng K.Y., Lam K.S.L. and Xu A., The E3 ligase TRAF6 regulates the insulin-sensitizing actions of the adaptor protein APPL1 through ubiquitination., Ubiquitin and ubiquitin like modifiers, 2011. . 2011.
Hoo R.L.C., Lee P.C., Cheng K.Y., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein mediates toxic-lipids-induced endoplasmic reticulum stress through inhibition of JAK-dependent autophagy, 7th International Symposium on Heathy Aging "Live Well Age Well", Research Centre of Heart, Brian, Hormone & Healthy Aging.. 2012.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.


Researcher : Cheng OY
List of Research Outputs

Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Cheng YY
Project Title:The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):Cheng YY, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2008




Researcher : Cheung AHK
List of Research Outputs

Lau K.W., Chan M.M.W., Yip B.H.K., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 31.
Lau K.W., Chan M.M.W., Yip B.H., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, PLoS One. 2012, 7(2): e31617.


Researcher : Cheung AMS
Project Title:Dissecting Variable Chemotherapeutic Drug Sensitivities in Human Acute Myeloid Leukemia (AML) Based on Differential Signalling Profiles
Investigator(s):Cheung AMS, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Cheung A.M.S., Leung D., Rostamirad S., Dhillon K., Miller P.H., Droumeva R., Brinkman R.R., Hogge D., Roy D.C. and Eaves C.J., Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation, Blood. 2012, 119(15): 3431-9.
Cheung A.M.S., Leung D. and Eaves C.J., Quantitative assays that discriminate human cells with variable durabilities of neutrophil and platelet output in NOD/SCID-IL-2Rγc-/- mice reveal marked quantitative but not qualitative differences between cord blood and mobilized peripheral blood., Experimental Hematology. 2011, 39(8, Supplement): S31-2.


Researcher : Cheung B.M.Y.
Project Title:Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):Cheung BMY, Lam KSL, Sham PC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010


Project Title:Does adrenomedullin reduce the inflammatory response caused by advanced glycation endproducts?
Investigator(s):Cheung BMY, Tan KCB, Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs



Researcher : Cheung BMY
Project Title:Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):Cheung BMY, Lam KSL, Sham PC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010


Project Title:Does adrenomedullin reduce the inflammatory response caused by advanced glycation endproducts?
Investigator(s):Cheung BMY, Tan KCB, Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Cheung B.M.Y. and Tang F., Adrenomedullin: Exciting New Horizons, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2012, 6 (1): 4-17.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y. and Cheung T.T., Challenges in the management of hypertension in Asia, European Heart Journal Supplements. Presented at the International Congress of Cardiology, Hong Kong 2012. 14 (A): 37-38.
Cheung B.M.Y. and Li C., Diabetes and hypertension: is there a common metabolic pathway?, Current Atherosclerosis Reports. 2012, 14 (2): 160-6.
Cheung B.M.Y., Drug treatment for obesity in the post-sibutramine era, Drug Safety 2011. 2011, 34(8): 641-650.
Cheung B.M.Y., Editiorial board member, Therapeutic Advances in Drug Safety. 2011.
Cheung B.M.Y., Editor-in-Chief, World Journal of Hypertension. 2011.
Cheung B.M.Y., Hypertention – a Cardiovascular Endemic, Presented at the Annual Scientific Meeting of the Hong Kong College of Physicians, Hong Kong 2011.
Cheung B.M.Y., Identifying and Management of the Resistant Hypertensive Patients, International Congress of Cardiology (ICC), Hong Kong. 2012.
Cheung B.M.Y., Natural history of hyperglycemia in Chinese, Journal of Diabetes Investigation. Presented at the 3rd Scientific Meeting of the Asian Association for the Study of Diabetes, Beijing, China 2012. 2011, 2 (Suppl 1): 17.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene , Eur J Endocrinol. 2011, 165(4): 571-7.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese, American Journal of Hypertension 2011. 2011, 24 (12): 1331-1337.
Cheung B.M.Y., Risk Management Programme: preliminary results, Hong Kong Cardiovascular Task Force Risk Management Programme Interim Meeting. 2012.
Cheung B.M.Y., The Natural History of Hyperglycemia in Chinese, 3rd Annual Meeting of Asian Association for the Study of Diabetes, Beijing. 2011.
Cheung B.M.Y., The New Guidelines on Hypertension, The 14th South China International Congress of Cardiology, Guangzhou. 2012.
Cheung B.M.Y., The New Nice Guidelines on the Treatment of Hypertension, Journal of the Hong Kong College of Cardiology. Presented at the Fifteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong 2011. 19 (2): 65.
Cheung B.M.Y., What can we do to halt the increase in blood pressure in the general population?, Eighth Scientific Conference on Cardiovascular Sciences Across the Strait, Yinchuan. 2011.
Cheung T.T. and Cheung B.M.Y., New NICE Guideline on the Treatment of Hypertension, Journal of the Hong Kong College of Cardiology. 2012, 20 (1): 15.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Chow W.S., Yuen M.A.M., Tso A.W.K., Fong H.Y., Lo S.V., Lam K.S.L. and Cheung B.M.Y., Non-traditional biomarkers in the prediction of cardiovascular events among Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 20.
Kumana C.R., Cheung B.M.Y. and Tan K.C.B., Impact on absolute mortality due to intensive glucose lowering for patients with diabetes, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 29.
Lam M.P.S. and Cheung B.M.Y., The Pharmacogenetics of the Response to Warfarin in Chinese, Br J Clin Pharmacol. 2012, 73: 340-7.
Lam M.P.S. and Cheung B.M.Y., The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population, Expert Rev Clin Pharmacol. 2012, 5: 187-97.
Lee P.C.H., Chow W.S., Yuen M.A.M., Tso A.W.K., Xu A., Law S.C., Cheung S.C.W., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin levels are predictive of carotid intima-medial thickness in a 5-year community-based prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 32.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 36.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgrad Med . 2011, 123(6): 66-71.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgraduate Medicine. 2011, 123(6): 66-71.
Ong K.L., Wu B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Arthritis: Its Prevalence, Risk Factors, and Association with Cardiovascular Diseases in the United States National Health and Nutrition Examination Survey 1999-2008, XVI International Symposium on Atherosclerosis 2012, Sydney. 2012.
Ong K.L., Wu B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Arthritis: Its prevalence, risk factors, and association with cardiovascular diseases in the United States National Health and Nutrition Examination Survey 1999-2008, Presented at the Scientific Sessions 2011 of the American Heart Association, United States 2011.
Ong K.L., Wu B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Association of higher total bilirubin level with rheumatoid arthritis in the United States National Health and Nutrition Examination Survey 1999-2008, XVI International Symposium on Atherosclerosis 2012, Sydney. 2012.
Ong K.L., Wu B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Association of lower total bilirubin level with statin usage: The United States National Health and Nutrition Examination Survey 1999–2008, Atherosclerosis. 2011, 219 (2): 728-33.
Ong K.L., Wu B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Association of lower total bilirubin level with statin usage: the United States National Health and Nutrition Examination Survey 1999-2008, Presented at the Annual Scientific Meeting of the Australian Atherosclerosis Society, Australia 2011.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure, Clinical and Experimental Hypertension 2011. 2011, 33 (7): 484-491.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Anti-obesity drugs-are they underused in the United States?, Journal of the Hong Kong College of Cardiology. Presented at the Fifteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong 2011. 19 (2): 69.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007-2008, Annals of Epidemiology. 2012, 22 (5): 349-53.
Samaranayake N.R., Chui W.C.M. and Cheung B.M.Y., Medication incidents related to technology in a university-affiliated general hospital in 2006-2010, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 45.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Presented at the International Medication Safety Conference, Hong Kong 2011.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Technology-related medication errors - incidence, nature and causes in a tertiary hospital, Presented at the Hospital Authority Convention 2012, Hong Kong, May 2012.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The Relationship between Waist Circumference and Glycated Hemoglobin in the United States, Journal of the Hong Kong College of Cardiology. Presented at the Twentieth Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong, May 2012. 20 (Suppl 1): A1.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between A1C and waist circumference in the US population, XVI International Symposium on Atherosclerosis 2012, Sydney. 2012.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between glycated haemoglobin and waist circumference in the US population, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 43.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of non-intercepted medication errors in a university affiliated teaching hospital, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.
Samaranayake N.R., Cheung S.T.D., Chui C.M.W. and Cheung B.M.Y., The pattern of non-intercepted medication errors in a university affiliated teaching hospital, Presented at the International Medication Safety Conference, Hong Kong 2011.
Thomas G.N., Macfarlane D.J., Guo B., Cheung B.M.Y., McGhee S., Chou K.L., Deeks J.J., Lam T.H. and Tomlinson B., Health promotion in older Chinese: a 12-month cluster randomized controlled trial of pedometry and "peer support", Medicine and Science in Sports and Exercise. 2012, 44 (6): 1157-66.
Thomas G.N., Scragg R., Jiang C., Chan Y.H., Marz W., Pilz S., Kim H.C., Tomlinson B., Bosch J., Lam T.H., Cheung B.M.Y. and Cheng K.K., Hyperglycaemia and vitamin d: a systematic overview, Current Diabetes Review. 2012, 8(1): 18-31.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.
Yu H.Y., Woo J., Chan R., Sham A., Ho S., Tso A.W.K., Cheung B.M.Y., Lam T.H. and Lam K.S.L., Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey, Public Health Nutrition 2011 . 2011, 14 (7): 1133-1141.


Researcher : Cheung CL
Project Title:Genome-Wide Association and Gene-and-Environment Interaction Studies of Vitamin D Insufficiency in Southern Chinese
Investigator(s):Cheung CL, Kung AWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011


List of Research Outputs

Cheung C.L., Nguyen U.S., Au E., Tan K.C.B. and Kung A.W.C., Association of handgrip strength with chronic diseases and multimorbidity: A cross-sectional study., Age. 2012.
Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.


Researcher : Cheung MS
Project Title:Dissecting Variable Chemotherapeutic Drug Sensitivities in Human Acute Myeloid Leukemia (AML) Based on Differential Signalling Profiles
Investigator(s):Cheung AMS, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs



Researcher : Cheung RTF
Project Title:Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:04/2005


Project Title:Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2009


Project Title:Evaluation of key mechanisms of brain injury and of a novel hemostatic treatment in a rat model of hypertensive intracerebral hemorrhage
Investigator(s):Cheung RTF, Ellis-Behnke RG, So KF, Wu EX
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Transplantation of neural stem cells in a rat model of intracerebral hemorrhage
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2010


Project Title:A pilot study of silent brain infarcts in healthy hypertensive elderly Chinese: the first 100 subjects
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Cheung R.T.F., Acute management of ischemic vertebrobasilar stroke, In: Daniel Agustin Godoy, Intensive Care in Neurology & Neurosurgery. Turin, Italy, SEEd, 2012, 615-624.
Cheung R.T.F., Associate Editor, Journal of Alzheimer’s Disease. 2012.
Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2012.
Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2012.
Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2011.
Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2012.
Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2011.
Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2011.
Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2012.
Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2012.
Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2011.
Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2012.
Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2011.
Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2012.
Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2012.
Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition. 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Lee T.M.C. and Cheung R.T.F., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development, and Cognition B. Aging, Neuropsychology and Cognition[Epub ahead of print]. 2012.
Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Chan Y.S., Mak H.K.F., Zhang J.X., Fung G. and Cheung C., Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer’s Disease , Journal of Alzheimer's Disease. 2011, 26: 47-58.
Gao J., Li S., Zhang Z., Sik H.H., Hung Y.S., Chan S.C., Cheung R.T.F. and Chang C., Spectral alteration of brain waves during MBSR meditation: a longitudinal EEG study, the 18th Annual Meeting of the Organization for Human Brain Mapping (OHBM2012). 2012.
Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Liu L. and Cheung R.T.F., Neuroprotection of melatonin and electro-acupuncture (EA) following focal cerebral ischemia in rats, Sixth International Symposium on Healthy Aging, Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012, 47.
Sang Y., Su H., Wu W., So K.F. and Cheung R.T.F., Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury, Journal of Neurotrauma. 2011, 28: 2523-2534.
Tse C.T., Chan K.H., Cheung R.T.F. and Ho S.L., Guillain-Barre syndrome associated with acute hepatitis E infection, Journal of Clinical Neuroscience. 2011, 19: 607-608.


Researcher : Cheung TK
List of Research Outputs

Tan V.P.Y., Wong W.M., Cheung T.K., Lai K.C., Chan P., Pang R.W.C. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., In: T. Azuma, Journal of Gastroenterology. Wiley InterScience, 2011, 46(7): 906-12.


Researcher : Cheung TT
List of Research Outputs

Cheung B.M.Y. and Cheung T.T., Challenges in the management of hypertension in Asia, European Heart Journal Supplements. Presented at the International Congress of Cardiology, Hong Kong 2012. 14 (A): 37-38.
Cheung T.T. and Cheung B.M.Y., New NICE Guideline on the Treatment of Hypertension, Journal of the Hong Kong College of Cardiology. 2012, 20 (1): 15.
Lau W.C.S. and Cheung T.T., Should clinicians start measuring flow mediated dilation response in patients with systemic lupus erythematosus? , The Journal of Rheumatology. 2011, 38(7): 1231-1233.


Researcher : Cheung WWW
List of Research Outputs

Au W.Y., Lee V., Lau C.W., Yau J., Chan D., Chan E.Y.T., Cheung W.W.W., Ha S.Y., Kho B., Lee C.Y., Li R.C.H., Li C.K., Lin S.Y., Ling A.S.C., Mak V., Sun L., Wong K.H.F., Wong R. and Yuen H.L., A synopsis of current care of thalassaemia major patients in Hong Kong, Hong Kong Medical Journal. 2011, 17(4): 261-266.


Researcher : Cheung YY
List of Research Outputs

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.


Researcher : Chim JCS
Project Title:FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Lee Hysan Foundation - General Award
Start Date:07/2008


Project Title:Functional study of the impact of hypermethylation of tumor suppressive micro-RNA in myeloma stem cells
Investigator(s):Chim JCS, Liang RHS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Methylation of miR-129 in hematological cancers
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:Study of methylation of microRNA in mantle cell lymphoma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Methylation of miR-224 in haematological cancers
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chim J.C.S., Epigenomics (impact factor:3.429), 2011.
Chim J.C.S., Frontiers in Epigenomics, 2011.
Chim J.C.S., Health (http://www.scirp.org/journal/health), 2011.
Chim J.C.S., Journal of Translational Medicine (impact factor: 3.5) , 2011.
Chim J.C.S., Wan T.S.K., Wong K.Y., Fung T.K., Drexler H.G. and Wong K.F., Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms, Journal of Translational Medicine. 2011, 197.
Chim J.C.S., PLoS ONE (impact factor: 4.41), 2011.
Chim J.C.S., The Open Leukemia Journal. 2011.
Chim J.C.S., The Open Translational Medicine Journal. 2011.
Chim J.C.S., Lie A.K.W., Chan Y.E.T., Liu H.S.Y., Lau C.W., Yip S.Y., Sim J., Wan T.S.K., Ma E.S.K., Liang R.H.S., Tse E.W.C. and Kwong Y.L., Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD, Journal of Hematology and Oncology. 2012, 8;5(1): 28.
Gill H., Kwok H., Mak H.K., Chim J.C.S. and Kwong Y.L., Positron emission tomography in the diagnosis of disseminated pyomyositis due to PVL-negative methicillin-resistant Staphylococcus aureus, QJM. 2012.
Hwang Y.Y., Loong F., Chung L.P. and Chim J.C.S., Atypical Burkitt’s lymphoma transforming from follicular lymphoma, Diagnostic Pathol. 2011, 8;6(1):: 63.
Li Z., Chim J.C.S., Yang M., Ye J., Wong B.C. and Qiao L., Role of PCDH10 and its hypermethylation in human gastric cancer. , Biochim Biophys Acta. 2011.
Morgan G., Johnsen H.E., Goldschmidt H., Palumbo A., Cavo M., Sonneveld P., San Miguel J.F., Chim J.C.S., Browne P.V., Einsele H., Waage A., Hajek R., Ludwig H., Turesson I., Spencer A. and Hemminki K., MAGIC (MyelomA Genetics International Consortium), Leuk Lymphoma. 2012, 53(5): 796-800.
Wong K.Y., Huang X.J. and Chim J.C.S., DNA methylation of microRNA genes in multiple myeloma, Carcinogenesis. 2012, 33(9): 1629-38.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.


Researcher : Chin WY
Project Title:Developing a set of quality criteria for community-based medical education in Hong Kong
Investigator(s):Chin WY, Johnston JM, Cheung ANY, Lam CLK
Department:Med - Family Medicine Unit
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2010
Completion Date:02/2012


Project Title:The epidemiology and natural history of depressive disorders in primary care
Investigator(s):Chin WY, Lam CLK, Lo YCY, Fong DYT, Lam TP, Lee PWH
Department:Med - Family Medicine Unit
Source(s) of Funding:Commissioned Research on Mental Health Policy and Services
Start Date:05/2010




Researcher : Chong BH
List of Research Outputs

Pong V., Chan K.H., Chong B.H., Lui W.M., Leung G.K.K., Tse H.F., Pu J.K.S. and Siu D.C.W., Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage. , Cerebellum. 2012.


Researcher : Chow CH
List of Research Outputs

Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.


Researcher : Chow WS
List of Research Outputs

Chow W.S., Yuen M.A.M., Tso A.W.K., Fong H.Y., Lo S.V., Lam K.S.L. and Cheung B.M.Y., Non-traditional biomarkers in the prediction of cardiovascular events among Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 20.
Lee C.H., Yuen M.M.A., Chow W.S., Tso A.W.K., Yeung C.K., Chan J.C.Y., Chau C.H. and Lam K.S.L., A man with a blistering eruption and tuberculosis, BMJ. 2012, 344: d8351.
Leung G.K.K., Lui W.M., Yuen M.M.A., Chow W.S. and Tse P.Y.H., An endoscopic modification of the simultaneous 'above and below' approach to large pituitary adenomas, Pituitary 2012. 2012, 15(2): 237-241.


Researcher : Chu ACY
List of Research Outputs

Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.


Researcher : Chu LW
Project Title:A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):Chu LW, Lam KSL, Lee PWH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2003


List of Research Outputs

Chan T.C., Hung I.F.N., Woo P.C.Y. and Chu L.W., Efficacy Of Dual Vaccination Of Pandemic H1n1 2009 Influenza And Seasonal Influenza On Institutionalized Elderly: A One-year Prospective Cohort Study., Vaccine. 2011, 29(44):7773-8.
Chan T.C., Hung I.F.N., Luk J.K.H., Woo P.C.Y. and Chu L.W., Prevention Of Mortality And Pneumonia Among Nursing Home Older Adults By Dual Pneumococcal And Seasonal Influenza Vaccination During A Pandemic Caused By Novel Pandemic Influenza A (h1n1)., J Am Med Dir Assoc. 2012.
Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.
Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., The genetic polymorphisms in sex steroid metabolic pathway and risk for sporadic Alzheimer's disease, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition. 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Lee T.M.C. and Cheung R.T.F., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development, and Cognition B. Aging, Neuropsychology and Cognition[Epub ahead of print]. 2012.
Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Chan Y.S., Mak H.K.F., Zhang J.X., Fung G. and Cheung C., Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer’s Disease , Journal of Alzheimer's Disease. 2011, 26: 47-58.
Lau C.F., Ho Y.S., Poon C.H., Wuwongse S., Chu L.W. and Chang R.C.C., Testosterone attenuated pre-synaptic disrutpion in beta-amyloid-treated rat hippocampal neurons, 7th International Symposium on Healthy Aging. 2012, 67.
Mak H.K.F., Zhang Z., Yau K.K.W., Zhang L., Chan Q. and Chu L.W., Discriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetry. , In: Ashford JW, Rosen A, Adamson M, Bayley P, Sabri O, Furst A, Black SE, Weiner M. , Advances in Alzheimer’s Disease 2. Handbook of Imaging the Alzheimer Brain. An Introduction. . IOS Press, 2011, 2: 729-738.
Mak H.K.F., Chan Q., Zhang Z., Petersen E., Qiu D., Zhang L., Yau K.K.W., Chu L.W. and Golay X., Quantitative assessment of cerebral hemodynamic parameters by QUASAR Arterial Spin Labeling in Alzheimer's disease and cognitively normal elderly adults at 3-Tesla. , Journal of Alzheimer’s Disease . 2012, 31: 33-44.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Chung ACK
Project Title:Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):Chung ACK, Lan HY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2008




Researcher : Chung HY
List of Research Outputs

Chung H.Y., Lau W.C.S., Wu K.P., Wong R.W.S. and Mok T.M.Y., Comparison of performance of the Assessment of Spondyloarthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis., Clinical Rheumatology . 2011, 30(7): 947-953.


Researcher : Chung IS
List of Research Outputs

Chung I.S., Ma C.H., Fung T.K. and Leung A.Y.H., Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis , Experimental Hematology. Elsevier, 2011.
Ma C.H., Chung I.S., Lin H., Yang D., Liang R.H.S. and Leung A.Y.H., Methionine aminopeptidase 2 (MetAP2) is required for zebrafish hematopoietic stem cell initiation, 7th European Zebrafish Meeting. 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.


Researcher : Dong M
List of Research Outputs

Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.


Researcher : Feng Z
Project Title:30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):Feng Z
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2000




Researcher : Fong HY
List of Research Outputs

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Chow W.S., Yuen M.A.M., Tso A.W.K., Fong H.Y., Lo S.V., Lam K.S.L. and Cheung B.M.Y., Non-traditional biomarkers in the prediction of cardiovascular events among Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 20.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.


Researcher : Fung JYY
List of Research Outputs

Chan S.C., Fan S.T., Chok K.S.H., Cheung T.T., Chan A.C.Y., Fung J.Y.Y., Poon R.T.P. and Lo C.M., Survival advantage of primary liver transplantation for hepatocellular carcinoma within the up-to-7 criteria with microvascular invasion, Hepatology International. 2011, Epub on 2011-10-21.
Chok K.S.H., Fung J.Y.Y., Chan S.C., Cheung T.T., Sharr W.W., Chan A.C.Y., Fan S.T. and Lo C.M., Outcomes of living donor liver transplantation for patients with preoperative type 1 hepatorenal syndrome and acute hepatic decompensation, Liver Transplantation. 2012, Epub on 2012-01-30.
Dai W.C., Chan S.C., Chok K.S.H., Cheung T.T., Sharr W.W., Chan A.C.Y., Fung J.Y.Y., Tsang S.H.Y., Fan S.T. and Lo C.M., Single-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variants in Chinese patients, Amyloid. 2012, 19(1): 33-36.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Sharr W.W., Chan A.C.Y., Dai W.C., Cheung T.T., Fan S.T., Lai C.L., Yuen R.M.F. and Lo C.M., Entecavir Versus Lamivudine Prophylaxis without Hepatitis B Immune Globulin after Liver Transplantation for Chronic Hepatitis B., 18th Annual International Congress on ILTS Location: San Francisco, USA. May 16-19, 2012. Liver Transplantation.. 2012, 18 (supp 1): S124.
Fung J.Y.Y., Cheung C.K.Y., Chan S.C., Yuen R.M.F., Chok K.S.H., Sharr W.W., Dai W.C., Chan A.C.Y., Cheung T.T., Tsang S.H.Y., Lam B.K.Y., Lai C.L. and Lo C.M., Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation, Gastroenterology. 2011, 141(4): 1212-1219.
Fung J.Y.Y., Chan S.C., Yuen R.M.F., Lai C.L., Chok K.S.H., Sharr W.W., Dai W.C., Fan S.T. and Lo C.M., Long-term Outcome of Lamivudine Mono-prophylaxis After Liver Transplantation In Hepatitis B Patients , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 450A-450A.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Epub 2011 Sep 29. Review., J Antimicrob Chemother . 2011, 66(12): 2715-25.
Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. {Epub 2010 Oct 19], J Hepatol. 2011, 54(2): 195-200.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y. and Lo C.M., Reply (Correspondence) (Refers to: Combined prophylaxis might still be better than monoprophylaxis with entecavir following liver transplantation for hepatitis B), Gastroenterology. 2012, 142(1): e34-35.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B , Hepatology International . 2011, 5(4): 868-875.
Seto W.K., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Fung PCW
List of Research Outputs

Lee W.S., Xu M., Li Y., Gu Y., Chen J., Wong D., Fung P.C.W. and Shen J., Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury., Arch Biochem Biophys. . 2011, 514(1-2): 57-67.


Researcher : Fung SL
List of Research Outputs

Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).


Researcher : Fung TK
List of Research Outputs

Chim J.C.S., Wan T.S.K., Wong K.Y., Fung T.K., Drexler H.G. and Wong K.F., Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms, Journal of Translational Medicine. 2011, 197.
Chung I.S., Ma C.H., Fung T.K. and Leung A.Y.H., Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis , Experimental Hematology. Elsevier, 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.


Researcher : Fung TK
List of Research Outputs

Chim J.C.S., Wan T.S.K., Wong K.Y., Fung T.K., Drexler H.G. and Wong K.F., Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms, Journal of Translational Medicine. 2011, 197.
Chung I.S., Ma C.H., Fung T.K. and Leung A.Y.H., Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis , Experimental Hematology. Elsevier, 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.


Researcher : Gao J
List of Research Outputs

Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition. 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Lee T.M.C. and Cheung R.T.F., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development, and Cognition B. Aging, Neuropsychology and Cognition[Epub ahead of print]. 2012.
Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Chan Y.S., Mak H.K.F., Zhang J.X., Fung G. and Cheung C., Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer’s Disease , Journal of Alzheimer's Disease. 2011, 26: 47-58.
Gao J., Li S., Zhang Z., Sik H.H., Hung Y.S., Chan S.C., Cheung R.T.F. and Chang C., Spectral alteration of brain waves during MBSR meditation: a longitudinal EEG study, the 18th Annual Meeting of the Organization for Human Brain Mapping (OHBM2012). 2012.


Researcher : Gao J
List of Research Outputs

Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition. 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Lee T.M.C. and Cheung R.T.F., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development, and Cognition B. Aging, Neuropsychology and Cognition[Epub ahead of print]. 2012.
Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Chan Y.S., Mak H.K.F., Zhang J.X., Fung G. and Cheung C., Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer’s Disease , Journal of Alzheimer's Disease. 2011, 26: 47-58.
Gao J., Li S., Zhang Z., Sik H.H., Hung Y.S., Chan S.C., Cheung R.T.F. and Chang C., Spectral alteration of brain waves during MBSR meditation: a longitudinal EEG study, the 18th Annual Meeting of the Organization for Human Brain Mapping (OHBM2012). 2012.


Researcher : Gao RY
List of Research Outputs

Xiao S., Kung A.W.C., Gao R.Y., Lau K.S., Ma C.H., Zhang Z.L., Liu J.M., Xia W., He J.W. and Zhao L., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density, Human Molecular Genetics. 2011.


Researcher : Gao Y
List of Research Outputs

Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.


Researcher : Ge X
List of Research Outputs

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.


Researcher : Guo Y
List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Ma C.H., He B., Guo Y. and Leung A.Y.H., Modeling Tumor Angiogenesis with Zebrafish, In: Dan T. Simionescu and Agneta Simionescu, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medicine. Rijeka Croatia, Intech, 2011, 133-144.


Researcher : Guo Y
List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Ma C.H., He B., Guo Y. and Leung A.Y.H., Modeling Tumor Angiogenesis with Zebrafish, In: Dan T. Simionescu and Agneta Simionescu, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medicine. Rijeka Croatia, Intech, 2011, 133-144.


Researcher : Ha CTJ
List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.


Researcher : Han Q
List of Research Outputs

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cellular mechanisms involved in intermittent hypoxia-induced heart damage in rat, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 23.
Mak J.C.W., Han Q., Yeung S.C. and Ip M.S.M., Effects of intermittent hypoxia on the expression levels of fatty acid-binding protein in rat heart, Am J Respir Crit Care Med. 2012, 185: A3869.


Researcher : He B
List of Research Outputs

Ma C.H., He B., Guo Y. and Leung A.Y.H., Modeling Tumor Angiogenesis with Zebrafish, In: Dan T. Simionescu and Agneta Simionescu, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medicine. Rijeka Croatia, Intech, 2011, 133-144.


Researcher : Ho JCM
Project Title:MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:07/2005


Project Title:A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):Ho JCM, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2007


Project Title:A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2007


Project Title:The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Lee Wing Tat Fund
Start Date:08/2007


Project Title:A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:11/2007


Project Title:A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2008


Project Title:A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:12/2008


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Hong Kong Lung Foundation Research Grant
Start Date:02/2009


Project Title:A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2009


Project Title:Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2010


Project Title:Study on systemic and airway cytokines and oxidative stress in patients undergoing haemopoietic stem cell transplantation (HSCT)
Investigator(s):Ho JCM, Lie AKW, Au WY, Liang RHS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:09/2010


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:03/2011


Project Title:A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2011


Project Title:Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2011


Project Title:In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):Ho JCM, Lam SK
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2012


Project Title:Gene expression profiling for potential resistance mechanisms of lung cancer to arsenic trioxide
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chan W.M., Lau L.S., Kwok K.M., Law W.L., Ho J.C.M., Chu K.M. and Poon R.T.P., A randomized, double-blind, placebo-controlled, ascending dose infusion trial of the pharmacokinetics of recombinant human Gelsolin in patients with decreased natural Gelsolin levels, American Thoracic Society International Conference, Denver, U.S.A., 13 - 18 May 2011. American Journal of Respiratory and Critical Care Medicine. 2011, 183: A5601.
Ho J.C.M., Advances in Lung Cancer . Scientific Research, 2012.
Ho J.C.M., Asia-Pacific Asthma Insight and Management. Asthma Expert Input Forum 2012. MSD. Singapore, 24 March, 2012.
Ho J.C.M., Avastin as add-on therapy to first-line platinum doublet: stage IV lung adenocarcinoma with bone metastases. Round Asia Oncology Forum 2011. Chinese Society of Clinical Oncology. Shanghai, China, 2011.
Ho J.C.M., Bronchogenic carcinoma: epidemiology, investigations and treatment. Post-registration certificate course in respiratory nursing. Institute of Advanced Nursing Studies, Hospital Authority, 23 August, 2011.
Ho J.C.M., Clinical Cancer Drugs . Bentham Science, 2012.
Ho J.C.M., Clinical Pulmonary Medicine . Lippincott Williams & Wilkins, 2012.
Ho J.C.M., Editorial Board Member (2012) of Interhospital Multi-disciplinary Programme on Antimicrobial Chemotherapy (IMPACT), 2012.
Ho J.C.M., Honorary Editorial Advisory Board - Asia Member (since 2006), MIMS Respiratory Guide. 2012.
Ho J.C.M., Recent advances in lung cancer. “Same Diseases, Different Continents” conference. Chinese American Medical Association of Southern California (CAMASC). Shanghai and Hong Kong, 13 November, 2011.
Ho J.C.M., Seminars in Respiratory and Critical Care Medicine. Thieme, 2012.
Lam S.K., Zheng C. and Ho J.C.M., Antiproliferative Effect of Arsenic Trioxide in Non-Small Cell Lung Carcinoma (NSCLC). 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S932 (P2.022).
Liao S., Li R.H.W., Ho J.C.M., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy, Journal of Clinical Endocrinology and Metabolism . Journal of Clinical Endocrinolog and Metabolism, 2012, 97: 2105-2112.
Lin J., Ho J.C.M., Hsu J.Y., Boonsawat W., Eng P., Cho Y.J., Manap R.A., Salvi S. and Thompson P., Perceptions of asthma control by patients in Asia-Pacific countries: results of the Asia-Pacific Asthma Insight and Management (AP-AIM) Survey, Respirology. 2011, 16(Suppl. 2): 209.
O W.S., Liao S., Li R.H.W., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., The role of adrenomedullin in tubal ectopic pregnancy, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 81 Abstract 124.
Salvi S., Manap R.A., Ho J.C.M., Boonsawat W., Cho Y.J., Eng P., Hsu J.Y., Thompson P. and Lin J., The Asia-Pacific Asthma Insight and Management Survey (AP-AIM): a multinational survey of asthma patients from 8 Asia-Pacific countries and Hong Kong, Respirology. 2011, 209.
Siu D.C.W., Wong M.P., Ho J.C.M., Lam C.L.D. and Tse H.F., Fatal lung toxicity related to Dronedarone use., Arch Int Med . 2012, 172 (6): 516 - 517.
Thompson P., Cho Y.J., Boonsawat W., Ho J.C.M., Eng P., Hsu J.Y., Manap R.A., Lin J. and Salvi S., The burden of asthma in Asia-Pacific (AP) countries: results of the AP Asthma Insight and Management (AIM) Survey of patients, Respirology. 2011, 16(Suppl. 2): 210.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.
Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).
Wong K.Y.M., Tam T.C., Lam C.L.D., Ip M.S.M. and Ho J.C.M., Endobronchial Ultrasound-guided aspiration in superior vena cava syndrome, Lung Cancer. 2012, Epub ahead of print.
Zhang Y., Tong Y., Sze C.W., Tang S.C.W., Ho J.C.M., Ng T.B. and Liao Q.X., Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation. , In: Zhang YB*, Tong Yao, Sze CW, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region. (Project code: ITS/313/11).. 2012.
Zhang Y., Sze C.W., Tong Y., Tang S.C.W., Ho J.C.M., Ng T.B. and Liao X.Q., PI: HK$223,300.00 (April 27, 2012). Zhang YB*, Stephen Sze CW, Tong Y, Ng TB, Liao XQ, Ho CM, Tang CW. Investigation of Therapeutic Efficacy and Mechanisms of Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced Pulmonary Inflammation. , In: Zhang YB*, Stephen Sze CW, Tong Y, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Fund Internship Programme of Hong Kong (Project code: InP/066/12).. 2012.
Zhang Y., Sze C.W., Tong Y., Ng T., Liao X., Tang S.C.W. and Ho J.C.M., PI: HK$826,701.00 (March 23, 2012). Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation. , In: Zhang YB*, Tong Yao, Sze CW, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region (Project code: ITS/313/11).. 2012.
Zheng C., Lam S.K. and Ho J.C.M., In-vitro Study of Arsenic Trioxide and Chemotherapeutic Agents in Small Cell Lung Carcinoma. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S933 (P2.023).


Researcher : Ho JCY
Project Title:Differentiation and Isolation of Endothelial Cells from Human Induced Pluripotent Stem Cells
Investigator(s):Ho JCY, Tse HF, Lai KWH
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:09/2011


List of Research Outputs

Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Ho SL
Project Title:Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):Ho SL, Song Y, Wang Y
Department:Medicine
Source(s) of Funding:Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:04/2007


List of Research Outputs

Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Ho S.L., Associate Editor, Clinical Neuropharmacology. USA, Lippincott Williams&Wilkins, 2012.
Ho S.L., Editorial Board Member, Brain and Behavior. USA, Wiley Publishers Inc, USA, 2012.
Ho S.L., Invited Chairperson., XIX World Federation of Neurology, World Congress on Parkinson’s Disease and Related Disorders, Shanghai . 2011.
Ho S.L., Section Editor, Translational Neruodegeneration. UK, BioMed Central, 2012.
Ho S.L., Treatment of the early Parkinson’s disease patients, 16th International Congress of Parkinson’s disease and Movement Disorders. Dublin, Ireland, 2012.
Ho S.L., Web Site Editorial Board, The Movement Disorder Society. The Movement Disorder Society, 2011.
Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Li M., Pang S.Y.Y., Song Y., Kung M.H.W., Ho S.L. and Sham P.C., Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family., Clinical Genetics. 2012, 3. doi: 10.1111/j.1399-0004.2012.01895.x.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.
Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.
Sung E., Turan N., Ho W.L., Ho S.L., Jarratt P.D.B., Waring R.H. and Ramsden D.B., Detection of endocrine disruptors - from simple assays to whole genome scanning., International Journal of Andrology . 2012.
Tse C.T., Chan K.H., Cheung R.T.F. and Ho S.L., Guillain-Barre syndrome associated with acute hepatitis E infection, Journal of Clinical Neuroscience. 2011, 19: 607-608.


Researcher : Ho WL
Project Title:Development of a novel human catechol-O-methyltransferase (COMT) assay to detect estrogenic inhibitors and inducers
Investigator(s):Ho WL, Ho SL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:06/2010
Completion Date:11/2011


Project Title:Pathological role of R1441G mutant leucine-rich repeat kinase 2 (LRRK2) in ubiquitin-proteasomal system and mitochondrial autophagy in Parkinson's disease
Investigator(s):Ho WL, Ho SL, Chan KH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011


List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.
Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.
Sung E., Turan N., Ho W.L., Ho S.L., Jarratt P.D.B., Waring R.H. and Ramsden D.B., Detection of endocrine disruptors - from simple assays to whole genome scanning., International Journal of Andrology . 2012.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Ho WM
Project Title:UCP4 is a target effector of NF-kappaB c-Rel pro-survival pathway against oxidative stress
Investigator(s):Ho WM, Ho SL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2011
Completion Date:05/2013


List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.
Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Hon FKS
List of Research Outputs

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.


Researcher : Hoo RLC
Project Title:The role of adipocyte fatty acid binding protein in association with autophagy in lipids-induced endoplasmic reticulum stress
Investigator(s):Hoo RLC, Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2011


Project Title:Adipocyte-derived small lipid-binding proteins as a mediator of obesity-induced cardiac dysfunction and heart failure
Investigator(s):Hoo RLC, Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


List of Research Outputs

Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H., Lam K.S.L. and Xu A., Growth Hormone Induces Hepatic Production Of Fibroblast Growth Factor 21 Through A Mechanism Dependent On Lipolysis In Adipocytes., Journal of Biological Chemistry. 2011, 286: 34559-66.
Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H.Y., Lam K.S.L. and Xu A., Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes., J Biol Chem. 2011, 286: 34559-66.
Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Hoo R.L.C., Lee P.C., Cheng K.Y., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein mediates toxic-lipids-induced endoplasmic reticulum stress through inhibition of JAK-dependent autophagy, 7th International Symposium on Heathy Aging "Live Well Age Well", Research Centre of Heart, Brian, Hormone & Healthy Aging.. 2012.
Hoo R.L.C., Lee P.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via its inhibition of autophagy, 17 th Medicial Research Conference. 2012.
Hoo R.L.C., Wong J.Y., Qiao C., Xu H., Xu A. and Lam K.S.L., An effective fraction isolated from Radix Astragali alleviates glucose tolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, The 5th International Conference on Diabetes, Teaching Hospital of Chengdu Unviersity of Traditional Chinese Medicine. 2012.
Hoo R.L.C., Wong J.Y., Lam K.S.L. and Xu A., The Role of Adipocyte Fatty Acid Binding Protein (A-FABP) in the Pathogenesis of Obesity-related Inflammatory Diseases. , Sixth International Symposium on Healthy Aging, 2011.. 2011.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.


Researcher : Hu HC
Project Title:A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):Hu HC, Lam CLK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:10/1998




Researcher : Huang FY
Project Title:Role of estrogen in regulating inflammatory gene expression and hepatocarcinogenesis
Investigator(s):Huang FY, Lai CL, Yuen RMF, Wong DKH
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2010
Completion Date:04/2012


List of Research Outputs

Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Cho C.H. and Yuen R.M.F., Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1β activation of nitric oxide production in gastric cancer cells., Cancer. 2012.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.


Researcher : Hui CK
Project Title:Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):Hui CK, Liang RHS, Lau G, Lie AKW
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Hui WM
List of Research Outputs

Cheng C., Chan T.N., Chio J.H., Chan P., Chan A.O.O. and Hui W.M., Being active or flexible?: Role of control coping on quality of life among patients with gastrointestinal cancer. Psycho-Oncology, 21, 211-218. , 2012.


Researcher : Hui X
Project Title:Sirt1 in adipocyte as a regulator of adipose tissue senescence and systemic energy homeostasis
Investigator(s):Hui X, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Hui X., Zhang M., Lam K.S.L. and Xu A., Adipocyte-Selective Disruption of SIRT1 Accelerates High Fat Diet and Aging induced Systemic Insulin Resistance via Modulation of Macrophage Infiltration and Polarization, 7th International Symposium on Healthy Aging. 2012.
Hui X., Lam K.S.L. and Xu A., Adipocyte-selective disruption of SIRT1 accelerates high fat diet and aging induced insulin resistance by modulation of macrophage infiltration and polarization, 17th Medical Research Conference. 2012.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update., Br J Pharmacol. 2012, 165(3): 574-90.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update, British Journal of Pharmacology. 2012, 165: 574-590.
Hui X., Best training scientist, 17th MRC. 2012.
Li H., Hui X., Wang Y. and Xu A., High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli , Protein Expression and Purification. 2011.


Researcher : Hung I.F.N.
Project Title:Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentres, randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection
Investigator(s):Hung IFN, Chan KH, Liang RHS, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Human Swine Influenza Research
Start Date:08/2009
Completion Date:12/2011


List of Research Outputs



Researcher : Hung IFN
Project Title:Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentres, randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection
Investigator(s):Hung IFN, Chan KH, Liang RHS, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Human Swine Influenza Research
Start Date:08/2009
Completion Date:12/2011


List of Research Outputs

Chan T.C., Hung I.F.N., Woo P.C.Y. and Chu L.W., Efficacy Of Dual Vaccination Of Pandemic H1n1 2009 Influenza And Seasonal Influenza On Institutionalized Elderly: A One-year Prospective Cohort Study., Vaccine. 2011, 29(44):7773-8.
Chan T.C., Hung I.F.N., Luk J.K.H., Woo P.C.Y. and Chu L.W., Prevention Of Mortality And Pneumonia Among Nursing Home Older Adults By Dual Pneumococcal And Seasonal Influenza Vaccination During A Pandemic Caused By Novel Pandemic Influenza A (h1n1)., J Am Med Dir Assoc. 2012.
Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.
Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Hung I.F.N., A Prospective Randomized Trial With 7-day Nitrofurantoin-containing Regime For Third-line Helicobacter Pylori Eradication, Digestive Disease Week (DDW) 2012, San Diego, USA. 2012.
Hung I.F.N., A Prospective Randomized, Open-label Trial Comparing The Safety And Efficacy Of Dose Sparing Intradermal 2010/2011 Trivalent Influenza Vaccine Delivered By Two Different Devices, 49th Annual Meeting Of Idsa (infectious Disease Society Of America) 2011, Boston, Usa. 2011.
Hung I.F.N., Advances In Endoscopy, 2012, Hospital Authority . 2012.
Hung I.F.N., Best Oral Presentation Award “five Days Quadruple Versus Clarithromycin Containing Triple Therapy As Empirical First And Second-line Treatment For Helicobacter Pylori Eradication: A Randomized Crossover Trial” , 19th European Gastroenterology Week (UEGW) Stockholm, Sweden 2011.. 2011.
Hung I.F.N., Current Adult Pneumococcal Vaccination Guidelines In Asia – Are They Adequate? , 2nd Appeal Asia Advisory Board 2011, Kuala Lumpur, Malaysia. 2011.
Hung I.F.N., Diabetic Autonomic Neuropathy Of The Gastrointestinal Tract, Seventh International Symposium on Health Aging, Hong Kong. 2012.
Hung I.F.N., Distinguished Research Paper Award For Young Investigators 2011 : “prevention Of Acute Myocardial Infarction And Stroke In The Elderly By Pneumococcal And Influenza Dual Vaccinations: A Prospective Cohort Study.”, Hong Kong College Of Physicians. 2011.
Hung I.F.N., Dual Vaccination Of Pneumococcal Vaccine And Influenza Vaccine – Efficacy On Elderly Led From Large-scale Cohort Study And Policy Change For Free Vaccination , Respiratory Infectious Diseases Vaccine Research Group Symposium 2011, Tokyo, Japan:. 2011.
Hung I.F.N., Five Days Quadruple Versus Clarithromycin Containing Triple Therapy As Empirical First And Second-line Treatment For Helicobacter Pylori Eradication: A Randomized Crossover Trial, 19th European Gastroenterology Week (uegw) Stockholm, Sweden 20. 2011.
Hung I.F.N., Multi-Drug Resistance Organisms: Management & Infection Control, 17th Hk Medical Forum. 2012.
Hung I.F.N. and To K.K.W., Quantitative And Qualitative Analysis Of Antibody Response After Dose Sparing Intradermal 2009 H1n1 Vaccination, Vaccine. 2011, 2707-8.
Hung I.F.N., Retrospective Single-center Trial Comparing Antegrade Spiral Enteroscopy With Single And Double-balloon Enteroscopy, Digestive Disease Week (DDW) 2012, San Diego, USA. 2012.
Hung I.F.N., Seasonal Influenza Vaccination, Asia Pacific Seasonal Influenza Advisory Board 2011, Singapore. 2011.
Hung I.F.N., Sir Patrick Manson Gold Medal – Best M.d. Thesis: Innovations In The Treatment And Prevention Of Influenza , Faculty Of Medicine, The University Of Hong Kong. 2012.
Hung I.F.N., Summary of H Pylori Eradication Trials in GCA, The 2nd Asia Pacific Topic Conference, 2012 Kuala Lumpur, Malaysia. 2012.
Hung I.F.N., The Benefits And Effectiveness Of Administrating Pneumococcal Polysaccharide Vaccine With Seasonal Influenza Vaccine, The Malaysian Society Of Cardiology. 2012.
Hung I.F.N., Update On Pneumococcal Infection And Vaccination, Annual Scientific Meeting 2011, Hong Kong College of Physicians. 2011.
Lei T., Siu K.L., Koh K.H., Chan K.H., Hung I.F.N., To K.K.W. and Yuen K.Y., Anti-ganglioside Antibodies Were Not Detected In Human Subjects Infected With Or Vaccinated Against 2009 Pandemic Influenza A (h1n1) Virus., Vaccine. 2012, 30(16):2605-10.
Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.
Leung J., Lim B., Ngo C., Lao W.C., Luk Y.W., Hung I.F.N., Li M. and Leung F.W., Head-to-Head Comparison of Practice with Endoscopic Retrograde Cholangiopancreatography Computer and Mechanical Simulators by Experienced Endoscopists and Trainees, Digestive Endoscopy. 2012, 24(3): 175-181.
Seto W.K.W., Lai C.L., Hung I.F.N. and Yuen R.M.F., A Large Population Histology Study Showing The Lack Of Association Between Alt Elevation And Significant Fibrosis In Chronic Hepatitis B., PLoS One. 2012, 7(2):e32622.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Tan V.P.Y., Wong R.W.M., Hung I.F.N. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., J Gastroenterol. 2011, 46(7):906-12.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Wu J.T.K., Leung S.M., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Characterizing the transmission dynamics and severity of the 2009 influenza pandemic in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.
Wu J.T.K., Ho W.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data, PLoS Medicine. 2011, 8(10): e1001103.
Wu J.T.K., Ho A.L.Y., Ma E., Lee C.K., Chu D., Ho P.L., Hung I.F.N., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real-time during an influenza pandemic (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, B619P.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.
Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.


Researcher : Ip MSM
Project Title:The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):Ip MSM
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:02/1997


Project Title:The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):Ip MSM, Peh WCG, Cooke MS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/1997


Project Title:Role of adiponectin in obstructive sleep apnoea
Investigator(s):Ip MSM, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):Ip MSM, Lam KSL, Song Y, Sham PC
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2005


List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Chan L.K., Lu J., Ip M.S.M. and Yip L.M., Effects of video triggers on the PBL process, In: Bridges S, McGrath C, Whitehill T , Problem-based learning in clinical education: The next generation. Dordrecht: Springer, 2012, 8: 139-150.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cellular mechanisms involved in intermittent hypoxia-induced heart damage in rat, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 23.
Ip M.S.M., Associate Editor, Chest. 2012.
Ip M.S.M., Breathe Well, Sleep Well, Age Well, 7th International Symposium on Healthy Aging: "Live Well Age Well", LKS Faculty of Medicine, The University of Hong Kong. 2012.
Ip M.S.M., Chairman, Scientific Symposium, 3rd Asia Pacific Region Conference of the International Union Against Tuberculosis and Lung Disease, Hong Kong. 2011.
Ip M.S.M., Chairman, Symposium, 16th Congress of the Asian Pacific Society of Respirology, Shanghai, China . 2011.
Ip M.S.M., Co-chairman, Comorbidities in Sleep Apnoea Symposium, Worldsleep 2011, Kyoto, Japan. 2011.
Ip M.S.M., Co-chairman, Diagnostic eveluation and treatment of upper airway disorders, CHEST 2011, Honolulu, USA. 2011.
Ip M.S.M., Cons: CPAP is a treatment for hypertension in obstructive sleep apnea, CHEST 2011, Honolulu, USA. 2011.
Ip M.S.M., Endothelial dysfunction in obstructive sleep apnea, 52th Annual Meeting of Japanese Respiratory Society, Osaka, Japan. 2012.
Ip M.S.M., Endothelial dysfunction in sleep related breathing disorders, Chinese Lung Cancer Prevention and Treatment Alliance (CLCPTA)-ACCP-Shanghai Respiratory Society (SRS) joint meeting, Shanghai, China. 2012.
Ip M.S.M., Impact of COPD in Asia Pacific Regions, CHEST 2011, Honolulu, USA. 2011.
Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2012.
Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2011.
Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2012.
Ip M.S.M., Member of Grant Review Board, Research Council, Food and Health Bureau, Government Secretariat, HKSAR. 2011.
Ip M.S.M., Member of Research Council, Food and Health Bureau, HKSAR. 2012.
Ip M.S.M., Member, Scientific Committee, 3rd Asia Pacific Region Conference of the International Union Against Tuberculosis and Lung Disease . 2011.
Ip M.S.M., Member, Steering Committee, European Respiratory Society Global Lung Taskforce. 2012.
Ip M.S.M., Member, American Thoracic Society Awards Committee. 2012.
Ip M.S.M., OSA and atherosclerosis - exploring the links , Worldsleep 2011, Kyoto, Japan. 2011.
Ip M.S.M., OSA and diabetes mellitus, Kyoto University, Kyoto, Japan. 2011.
Ip M.S.M., President, Asian Pacific Society of Respirology. 2012.
Ip M.S.M., Fukuchi Y. and Berend N., Respiratory health issues in the Asia-Pacific region: an epilogue, Respirology. 2012, 17(1): 1-2.
Ip M.S.M., Sleep apnoea, type 2 diabetes and the metabolic syndrome, Worldsleep 2011, Kyoto, Japan. 2011.
Ip M.S.M., The impact of intermittent hypoxia on metabolism - A model of sleep apnea, 12th Annual Congress of the Chinese Society of Respiratory Diseases, Guangzhou, China. 2011.
Lai A.Y.K., Lam C.M.J., Svikis D.P., Fong D.Y.T. and Ip M.S.M., Self-efficacy predicts adherence to continuous positive airway pressure therapy in obstructive sleep apnea, American Thoracic Society International Conference, San Francisco, USA. 2012, Programme Book: p.A3846.
Lam C.L.D., Girard L., Beer D.G., Gerald W.L., Kris M., Sihoe A.D.L., Cheng L.C., Wong M.P., Chung L.P., Ip M.S.M., Lam W.K., Gazdar A.F., Wistuba I.I. and Minna J.D., Expression of LATS2 and STK17B distinguishes epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 from those in 18 and 20 in lung adenocarcinomas, World Congress of Lung Cancer 2011.
Lam C.L.D., Fong D.Y.T., Yu W.C., Ko F.W., Lau A.C., Chan J.W., Choo K.L., Mok T.Y., Tam C.Y., Ip M.S.M. and Chan M.M.W., FEV3, FEV6 and their derivatives for detecting airflow obstruction in adult Chinese, Int J Tuberc Lung Dis. 2012, 16 (5): 681 - 686.
Lam C.L.D., Hui C.K. and Ip M.S.M., Issues in pulmonary function testing for screening and diagnosis of COPD, Current Opinion in Pulmonary Medicine. 2012, 18 (2): 104 - 111.
Lam C.M.J., Tan K.C.B., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea., Sleep Medicine. 2012, 13(1): 15-20.
Lam J.C.M., Mak J.C.W. and Ip M.S.M., Obesity, obstructive sleep apnea and metabolic syndrome, Respirology. 2012, 17(2): 223-236.
Lau K.W., Chan C.H., Law A.C.K., Ip M.S.M. and Mak J.C.W., The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells, Toxicol Sci. 2012, 125(2): 569-577.
Lau K.W., Chan M.M.W., Yip B.H.K., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 31.
Lau K.W., Chan M.M.W., Yip B.H., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, PLoS One. 2012, 7(2): e31617.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.
Lui M.M.S., Tse H.F., Mak J.C.W., Lam J.C.M., Lam C.L.D., Tan K.C.B. and Ip M.S.M., Altered endothelial repair capacity in obstructive sleep apnea in relation to elevated advanced glycation endproducts., Asia Pacific Society of Respirology Annual Congress, Nov 2011, Shanghai.. 2011.
Lui M.M.S. and Ip M.S.M., OSA and atherosclerosis, Journal of Thoracic Disease. 2012, 4: 164-172.
Lui M.M.S., Lam C.L.D. and Ip M.S.M., Significance of endothelial dysfunction in sleep-related breathing disorder, Respirology. 2012, Epub ahead of print.
Mak J.C.W., Han Q., Yeung S.C. and Ip M.S.M., Effects of intermittent hypoxia on the expression levels of fatty acid-binding protein in rat heart, Am J Respir Crit Care Med. 2012, 185: A3869.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.
Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).
Wong K.Y.M., Tam T.C., Lam C.L.D., Ip M.S.M. and Ho J.C.M., Endobronchial Ultrasound-guided aspiration in superior vena cava syndrome, Lung Cancer. 2012, Epub ahead of print.
Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase Activity Facilitates Syndecan-1 Shedding in Airway Inflammation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.


Researcher : Jin Y
Project Title:Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):Jin Y, Kwong YL, Tsao GSW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2002




Researcher : Kong MCW
Project Title:Characterization of early-staged human embryonic stem cells cardiomyocytes (hESC-CMs): A potential cell source for successful cardiomyoplasty
Investigator(s):Kong MCW, Li RA
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Fu J.D., Rushing S.N., Lieu D.K., Chan C.W.Y., Kong M.C.W., Geng L., Wilson K.D., Chiamvimonvat N., Boheler K.R. and Wu J.C., Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes, PLoS One. 2011, 6(11): e27417.
Kong M.C.W., Chen S., Geng L., Sun D. and Li R.A., Laser and chemical induced fusion to reverse engineer the physical size of hESC-derived CMs: a nongenetic approach for driven physiological hypertrophy and maturation., Days of Molecular Medicine 2011.
Li R.A., Chan C.W.Y., Kong M.C.W., Kenneth R. Boheler K.B., Ji-Dong Fu J.D.F., Stephanie N. Rushing, S.R., Deborah K. Lie D.L., Geng L., Kitchener D. Wilson K.W., Nipavan Chiamvimonvat N.C. and Joseph C. Wu J.W., Gordon Keller G.K., Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes., PloS One. 6(11):e27417.. 2011.
Li S., Yeung H.M., Kong M.C.W. and Li R.A., Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes., Days of Molecular Medicine, 2011.
Wang J., Lieu D.K., Karakikes I., Chen A., Turnbull I., Kong M.C.W., Hajjar R., Costa K., Khine M. and Li R.A., Engineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: An accurate arrhythmias model for cardiotoxicity screening., Days of Molecular Medicine, 2011.


Researcher : Kumana CR
List of Research Outputs

Kumana C.R., Cheung B.M.Y. and Tan K.C.B., Impact on absolute mortality due to intensive glucose lowering for patients with diabetes, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 29.


Researcher : Kung AWC
Project Title:Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):Kung AWC, McGhee S
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:10/2009


List of Research Outputs

Cheung C.L., Nguyen U.S., Au E., Tan K.C.B. and Kung A.W.C., Association of handgrip strength with chronic diseases and multimorbidity: A cross-sectional study., Age. 2012.
Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.
Xiao S., Kung A.W.C., Gao R.Y., Lau K.S., Ma C.H., Zhang Z.L., Liu J.M., Xia W., He J.W. and Zhao L., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density, Human Molecular Genetics. 2011.


Researcher : Kung MHW
List of Research Outputs

Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Li M., Pang S.Y.Y., Song Y., Kung M.H.W., Ho S.L. and Sham P.C., Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family., Clinical Genetics. 2012, 3. doi: 10.1111/j.1399-0004.2012.01895.x.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.


Researcher : Kwan SC
List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.
Chan K.H., Tsang K.L., Ho W.L., Tse C.T., Kwan S.C., Ho W.M., Chu A.C.Y., Chang R.S.K. and Ho S.L., Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese, Clinical Neurology and Neurosurgery. 2011, 113: 617-622.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Kwan WMM
List of Research Outputs

Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.


Researcher : Kwong YL
Project Title:Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):Kwong YL, Liang RHS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/1997


Project Title:Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):Kwong YL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Molecular basis of arsenic resistance in tumours
Investigator(s):Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):Kwong YL, Liang RHS, Lie AKW, Au WY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2004


Project Title:Provision of ibritumomab for the treatment of lymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):Kwong YL, Au WY, Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:05/2010


Project Title:Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


List of Research Outputs

Au W.Y., Li C.K., Lee V., Yuen H.L., Yau J., Chan G.C.F., Ha S.Y. and Kwong Y.L., Oral arsenic trioxide for relapsed acute promyelocytic leukemia in pediatric patients, Pediatric Blood Cancer. 2012, 58(4): 630-632.
Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.C., Leung A.Y.H., Wong A.S., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft patients, Renal Failure . 2012, 34: 550-554.
Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chan T.S., Gill H., Leung A.Y.H., Chan W.M., Khong P.L. and Kwong Y.L., Uveitis as the initial manifestation of diffuse large B-cell lymphoma, American Journal of Hematology . 2012, 87(2): 198-200.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Chim J.C.S., Lie A.K.W., Chan Y.E.T., Liu H.S.Y., Lau C.W., Yip S.Y., Sim J., Wan T.S.K., Ma E.S.K., Liang R.H.S., Tse E.W.C. and Kwong Y.L., Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD, Journal of Hematology and Oncology. 2012, 8;5(1): 28.
Gill H., Kwok H., Mak H.K., Chim J.C.S. and Kwong Y.L., Positron emission tomography in the diagnosis of disseminated pyomyositis due to PVL-negative methicillin-resistant Staphylococcus aureus, QJM. 2012.
Gill H., Cheung J., Wong Y.H.I., Lie A.K.W. and Kwong Y.L., Varicella zoster virus progressive outer retinal necrosis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2012, 157: 279.
Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.
Singh G.H., Ip A.H., So J.C.C., Cheng V.C.C., Wong C.S., Yuen K.Y. and Kwong Y.L., Disseminated cryptococcosis mimicking a lymphoma, Eur J Haematol. 2012, 88(3): 275-6.
Tse E.W.C., Leung A.Y.H., Sim P.Y.J., Lee H.K., Liu H.S., Yip S.F. and Kwong Y.L., Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia., ANNALS OF HEMATOLOGY. 2011, 90(11): 1277-81.
Tse E.W.C. and Kwong Y.L., Treatment algorithms for mature T-cell and natural killer-cell neoplasms, Future Oncology. 2011, 7(9): 1101-12.


Researcher : Lai AYK
Project Title:Long-term efficacy of an extended education programme on improving treatment adherence to continuous positive airway pressure in obstructive sleep apnea
Investigator(s):Lai AYK, Ip MSM, Lam CMJ, Fong DYT
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Mini Grants
Start Date:08/2011


List of Research Outputs

Lai A.Y.K., Lam C.M.J., Svikis D.P., Fong D.Y.T. and Ip M.S.M., Self-efficacy predicts adherence to continuous positive airway pressure therapy in obstructive sleep apnea, American Thoracic Society International Conference, San Francisco, USA. 2012, Programme Book: p.A3846.
Lam C.M.J., Tan K.C.B., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea., Sleep Medicine. 2012, 13(1): 15-20.


Researcher : Lai CL
Project Title:A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2003


Project Title:Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:10/2003


Project Title:A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Idenix Pharmaceuticals, Inc - General Award
Start Date:01/2004


List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Sharr W.W., Chan A.C.Y., Dai W.C., Cheung T.T., Fan S.T., Lai C.L., Yuen R.M.F. and Lo C.M., Entecavir Versus Lamivudine Prophylaxis without Hepatitis B Immune Globulin after Liver Transplantation for Chronic Hepatitis B., 18th Annual International Congress on ILTS Location: San Francisco, USA. May 16-19, 2012. Liver Transplantation.. 2012, 18 (supp 1): S124.
Fung J.Y.Y., Cheung C.K.Y., Chan S.C., Yuen R.M.F., Chok K.S.H., Sharr W.W., Dai W.C., Chan A.C.Y., Cheung T.T., Tsang S.H.Y., Lam B.K.Y., Lai C.L. and Lo C.M., Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation, Gastroenterology. 2011, 141(4): 1212-1219.
Fung J.Y.Y., Chan S.C., Yuen R.M.F., Lai C.L., Chok K.S.H., Sharr W.W., Dai W.C., Fan S.T. and Lo C.M., Long-term Outcome of Lamivudine Mono-prophylaxis After Liver Transplantation In Hepatitis B Patients , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 450A-450A.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Epub 2011 Sep 29. Review., J Antimicrob Chemother . 2011, 66(12): 2715-25.
Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. {Epub 2010 Oct 19], J Hepatol. 2011, 54(2): 195-200.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B , Hepatology International . 2011, 5(4): 868-875.
Gish R., Chang T.T., Lai C.L., De Man R.A., Gadano A., Yu S., Llamoso C. and Tang H., Digestive Disease Week (DDW), San Diego, CA, USA between 19-22 May 2012. Gastroenterology. 2012, 142(5): Suppl(1):S-917.
Huang J.Q., Zheng G.F., Lai C.L., Yuen R.M.F. and Wong B.C.Y., Risk of liver cancer in patients with hepatitis B or C. Review, Hong Kong Mededical Journal. 2011, 17 (Suppl 6): 41-3.
Lai C.L., Co-chairperson of Symposium 2: HCC pathogenesis, 9th APASL STC Hepatocellular Carcinoma: From Basics to Cure, Jeju, Korea, 1st-3rd December. 2011.
Lai C.L., Co-chairperson of the Welcome & Overview: Day 1 Review Program Agenda and Objectives, MSD Asia Pacific HCV Speakers’ Forum: Evolving Concepts in HCV Therapy, 10th-11th December. 2011.
Lai C.L., Co-chairperson of the symposium “Update on Hepatitis B”, 15th International Congress on Infectious Diseases (ICID), Bangkok, Thailand between June 13-16, 2012. 2012.
Lai C.L., Current Therapy of Chronic Hepatitis B, 2nd Wave B-Bridge in China, Chengdu and Shenyang, China, between May 29 & 30. 2012.
Lai C.L., Current Therapy of Chronic Hepatitis B, B-Focus in China organized by Chinese Journal of Infectious Diseases, Guangzhou, China, 19th-20th May. 2012.
Lai C.L., Current therapy of chronic hepatitis B – nucleos(t)ide analogues and drug resistance, 22nd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2012), Plenary Lecture and Postgraduate Course, Taipei, Taiwan, 16th-19th February. 2012.
Lai C.L., Current therapy of chronic hepatitis B: nucleos/tide analogues and drug resistance, Baraclude High 5 Symposium, Korea, 26th-28th March. 2012.
Lai C.L., HBV vaccination and antiviral therapy, Fifth International Liver Cancer Association (ILCA) Annual Conference, Hong Kong, 2nd-4th September. 2011.
Lai C.L., HKASLD Expert Meeting: Trouble-free management of hepatitis B patients, Hong Kong, July 5. 2011.
Lai C.L., Making headway – long-term Asian data from clinical trials and clinical practice, 22nd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2012), BMS Sponsored Satellite Symposium, Taipei, Taiwan, 16th-19th February. 2012.
Lai C.L., Management of HBV in patients on immunosuppressants, Multi-specialty Medical Mega Conference 2.0, Hong Kong, 14th-15th April. 2012.
Lai C.L., New and future treatment for chronic hepatitis C, Infection Control Association of Macao, Macau, 16th March. 2012.
Lai C.L., Plenary lecture entitled "Treating hepatitis B in 2012", 15th International Congress on Infectious Diseases (ICID), Bangkok, Thailand between June 13-16, 2012. 2012.
Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.H., Kweon Y.O., Sohn J.H., Lee J., Kim J.A., Han K.H. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54(Suppl:1): 1442A.
Lai C.L., Prevention of hepatocellular carcinoma: HBV vaccination and anti-viral therapy, State Key Laboratory for Liver Research (SKLLR) Symposium, The University of Hong Kong, Hong Kong, 24th September. 2011.
Lai C.L., Recent controversies in the management of hepatitis B patients, MSGEH Expert Meeting, Macau, 13th January. 2012.
Lai C.L., Resistance Considerations in CHB Management, Gilead Post-EASL Regional Advisory Programs, in San Francisco, Costa Mesa, Los Angeles, and New York, USA between May 5-19, 2012. 2012.
Lai C.L., The Acronym Quartet: CHB, cccDNA, OHB & HCC, Grand Round Research Meeting, Department of Medicine, The University of Hong Kong, Hong Kong, 26th May. 2012.
Lai C.L., The etiology of ‘cryptogenic’ hepatocellular carcinoma, International Symposium on Hepatology 2011, 24th Annual Scientific Meeting, The Hong Kong Association for the Study of Liver Diseases, Hong Kong, 20th November. 2011.
Lai C.L., The future development in hepatology, 30th Anniversary Scientific Meeting of the Hong Kong Society of Gastroenterology, Hong Kong, 9th December. 2011.
Lai C.L., The long-term management of CHB patients – insights obtained from special population, HKASLD Expert Meeting: Trouble-free management of hepatitis B patients, Hong Kong, 5th July. 2011.
Lai C.L., Ahh S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.H., Kweon Y.O., Sohn J.H., Lee J., Kim J.A., Han K.H. and Yuen R.M.F., Week 48 Analysis Of A Phase Iib Study Of The Efficacy And Safety Of Lb80380 Vs. Entecavir In Treatment-naive Patients With Chronic Hepatitis B, 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology. 2011, 54(Supp: 1): 1442A.
Lai C.L., What treatment outcomes could lead to stopping antiviral therapy in CHB?, Asia Hepatology Perspectives Forum – Long-term treatment and disease outcomes in chronic hepatitis B, Hong Kong, 26th-27th November. 2011.
Lai C.L., When can we stop anti-viral agents for chronic hepatitis B?, 17th Hong Kong Medical Forum, Hong Kong, 12th-13th May. 2012.
Lam Y.F., Yuen R.M.F., Seto W.K.W. and Lai C.L., Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety., Current Hepatitis Reports. 2011, 10(4): 235-243.
Pan C.Q., Tong M., Kowdley K.V., Hu KQ K.Q., Chang T.T., Lai C.L., Yoon S.K., Lee S.S., Cohen D., Tang H. and Tsai N., High Rates of Viral Suppression After Long-term Entecavir Treatment of Asian Patients With Hepatitis B e Antigen–Positive Chronic Hepatitis B., Clin Gastroenterol Hepatol. 2012, 10(9): 1047-1050.e1.
Seto W.K., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L., Hung I.F.N. and Yuen R.M.F., A Large Population Histology Study Showing The Lack Of Association Between Alt Elevation And Significant Fibrosis In Chronic Hepatitis B., PLoS One. 2012, 7(2):e32622.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Acute-on-chronic liver failure in chronic hepatitis B., Journal of Gastroenterology and Hepatology. 2012, 27(4): 662-9.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Nucleic acid testing for the detection of HBV DNA., Hepatitis Monthly. 2011, 11(10): 847-8.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Lai CTM
List of Research Outputs

Chow P.C., Lai C.T.M. and Cheung Y.F., Resting Systemic Right Ventricular Dyssynchrony is Associated with Reduced Contractile Reserve during Exercise Stress in Adults after Atrial Switch Repair for Complete Transposition of the Great Arteries (Abstract Presentation), The 4th Congress of Asia-Pacific Pediatric Cardiac Society, Taipei, Taiwan, April 4 to 7, 2012 . 2012.
Ho P.K., Lai C.T.M., Wong S.J. and Cheung Y.F., Three-dimensional mechanical dyssynchrony and myocardial deformation of the left ventricle in patients with tricuspid atresia after Fontan procedure, Journal of the American Society of Echocardiography. 2012, 25: 393-400.
Lai C.T.M., Chow P.C., Wong S.J., Chan K.W. and Cheung Y.F., Annexin A5 Levels in Patients after Atrial Switch Operation for TGA: Association with Impaired Systemic Ventricular Myocardial Deformation (Abstract Presentation), The 4th Congress of Asia-Pacific Pediatric Cardiac Society, Taipei, Taiwan, April 4 to 7, 2012 . 2012.
Lai C.T.M., Ng E.K., Chow P.C., Kwong A. and Cheung Y.F., Circulating Microrna Expression Profile in Adult Patients with a Systemic Right Ventricle after Atrial Switch Operation for Complete Transposition of the Great Arteries (Abstract Presentation), The 4th Congress of Asia-Pacific Pediatric Cardiac Society, Taipei, Taiwan, April 4 to 7, 2012.
Lai C.T.M., Chan K.W., Wong S.J., Chow P.C. and Cheung Y.F., Circulating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot , American Heart Journal . 2011, 162: 467-473.


Researcher : Lai KC
List of Research Outputs

Tan V.P.Y., Wong W.M., Cheung T.K., Lai K.C., Chan P., Pang R.W.C. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., In: T. Azuma, Journal of Gastroenterology. Wiley InterScience, 2011, 46(7): 906-12.


Researcher : Lai KN
Project Title:The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):Lai KN, Leung JCK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.C., Leung A.Y.H., Wong A.S., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft patients, Renal Failure . 2012, 34: 550-554.
Lai K.N., Lam M.F., Leung J.C.K., Chan Y.Y., Lam C.W., Chan I.H., Chan H.W., Li C.S., Wong S.S., Ho Y.W., CHEUK A., Tang M.K. and Tang S.C.W., A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products, Peritoneal Dialysis International. 2011, 32(3): 280-91.
Lai K.N., Pathogenesis of IgA nephropathy, Nature Reviews Nephrology. 2012, 8(5): 275-83.
Lai K.N., Tang S.C.W. and Leung J.C.K., Recent advances in IgA nephropathy - the glomerulopodocytic-tubular communication, Advances in Otorhinolaryngology. 2011, 72: 40-4.
Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in IgA nephropathy – the glomerulo-podocytic-tubular communication, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 72: 40-44.
Leung J.C.K., Chan Y.Y., Tang S.C.W., Lam M.F., Chow C.W., Lim A.I. and Lai K.N., Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone, Journal of Translational Medicine. 2011, 9: 169-183.
Leung J.C.K., Chan Y.Y., Lam M.F., Tang S.C.W., Chow C.W., Lim A.I. and Lai K.N., The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid, Nephrology Dialysis Transplantation ePub. 2012.
Lim A.I., Chan Y.Y., Lai K.N., Tang S.C.W., Chow C.W., Lam M.F. and Leung J.C.K., Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells, International Journal of Biochemistry and Cell Biology . 2012, 44: 1040-1050.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Tang S.C.W., Lin M., Tam K.Y., Au W.S., Ma M.K., Ho W.Y. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrol. Dial. Transplant.. 2012, 27: 613-8.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents Against IgA Nephropathy, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 45-49.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents against IgA Nephropathy, Advances in Otorhinolaryngol. 2011, 72: 45-9.
Tang S.C.W. and Lai K.N., The pathogenic role of the renal proximal tubular cell in diabetic nephropathy, Nephrology Dialysis Transplantation. 2012, ePub.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.
Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.
Yue Z., Pei Y., Sun L., Huang W., Huang H., Hu B., YANG J., Jiang X., Mo Y., Chen S., Lai K.N. and Wang Y., Clinical pictures and novel mutations of WT1-associated Denys-Drash syndrome in two Chinese children, Renal Failure. 2011, 33(9): 910-4.
Zhao Q., Peng L., Huang W., Li Q., Pei Y., Yuan P., Zheng L., Zhang Y., Deng J., Zhong C., Hu B., Ding H., Fang W., Li R., Liao Q., Lin C., Deng W., Yan H., Hou J., Wu Q., Xu T., Liu J., Hu L., Peng T., Chen S., Lai K.N., Yuen R.M.F., Wang Y., Maini M.K., Li C., Li M., Wang J., Zhang X., Zhang X., Sham P.C., Wang J., Gao Z.L. and Wang Y., Rare inborn errors associated with chronic hepatitis B virus infection., Hepatology. 2012.


Researcher : Lai KWH
List of Research Outputs

Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Lai WW
List of Research Outputs

Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.


Researcher : Lam CL
Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


List of Research Outputs



Researcher : Lam CLD
Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


List of Research Outputs

Lam C.L.D., 1. Pulmonary function testing -”Normal” values 2. Pulmonary function testing – Interpretation , Certificate Course on Basic Pulmonary Function Testing -For KWC health care professionals . 2012.
Lam C.L.D., EGFR mutation testing should be routinely performed in lung cancer, CHEST 2011. 2011.
Lam C.L.D., Girard L., Beer D.G., Gerald W.L., Kris M., Sihoe A.D.L., Cheng L.C., Wong M.P., Chung L.P., Ip M.S.M., Lam W.K., Gazdar A.F., Wistuba I.I. and Minna J.D., Expression of LATS2 and STK17B distinguishes epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 from those in 18 and 20 in lung adenocarcinomas, World Congress of Lung Cancer 2011.
Lam C.L.D., Fong D.Y.T., Yu W.C., Ko F.W., Lau A.C., Chan J.W., Choo K.L., Mok T.Y., Tam C.Y., Ip M.S.M. and Chan M.M.W., FEV3, FEV6 and their derivatives for detecting airflow obstruction in adult Chinese, Int J Tuberc Lung Dis. 2012, 16 (5): 681 - 686.
Lam C.L.D. and Minna J.D., How do we safely get people to stop smoking?, Cancer Prevention Research. 2011, 4: 1724 - 1727.
Lam C.L.D., Hui C.K. and Ip M.S.M., Issues in pulmonary function testing for screening and diagnosis of COPD, Current Opinion in Pulmonary Medicine. 2012, 18 (2): 104 - 111.
Lam C.L.D., Lung Cancer from Prevention to End-of-Life Care, The 16th Congress of Asian-Pacific Society of Respirology, Shanghai, China. 2011.
Lam C.L.D., Recent Advances in Bronchoscopic Imaging, Advances in Endoscopy 2012 Queen Mary Hospital and Tung Wah Hospital . 2012.
Lam C.L.D., Respirology. 2012.
Lam C.M.J., Tan K.C.B., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea., Sleep Medicine. 2012, 13(1): 15-20.
Liang B.M., Lam C.L.D. and Feng Y.L., Clinical applications of lung function testing: a revisit, Respirology. 2012, 17 (4): 611 - 619.
Lui M.M.S., Tse H.F., Mak J.C.W., Lam J.C.M., Lam C.L.D., Tan K.C.B. and Ip M.S.M., Altered endothelial repair capacity in obstructive sleep apnea in relation to elevated advanced glycation endproducts., Asia Pacific Society of Respirology Annual Congress, Nov 2011, Shanghai.. 2011.
Lui M.M.S., Lam C.L.D. and Ip M.S.M., Significance of endothelial dysfunction in sleep-related breathing disorder, Respirology. 2012, Epub ahead of print.
Siu D.C.W., Wong M.P., Ho J.C.M., Lam C.L.D. and Tse H.F., Fatal lung toxicity related to Dronedarone use., Arch Int Med . 2012, 172 (6): 516 - 517.
Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).
Wong K.Y.M., Tam T.C., Lam C.L.D., Ip M.S.M. and Ho J.C.M., Endobronchial Ultrasound-guided aspiration in superior vena cava syndrome, Lung Cancer. 2012, Epub ahead of print.


Researcher : Lam CLK
Project Title:Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):Lam CLK, Wong W
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:A Study on Health-related Quality of Life of patients with Colorectal Neoplasm and Cost-Effectiveness Analysis of Colorectal Cancer Screening in Hong Kong
Investigator(s):Lam CLK, Poon TCJ, Wong CKH, McGhee S, Fong DYT
Department:Family Medicine and Primary Care
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2010


Project Title:Extended evaluation of quality of care of chronic disease management programmes and public-private partnership programmes of the Hospital Authority
Investigator(s):Lam CLK, Wong WCW, Chin WY, Chen JY, Fung SCC, Fong DYT, Chim D, McCready CE
Department:Family Medicine and Primary Care
Source(s) of Funding:Commissioned Study on Enhanced Primary Care
Start Date:07/2011


Project Title:18th Annual Conference of the International Soceity for Quality of Life Research Validation of the Traditional Chinese Medicine 'Not-yel-ill' physiological constitution concept by health-related quality of life
Investigator(s):Lam CLK
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:10/2011


List of Research Outputs

Lam K.F.K., Liu X., Lam C.L.K., Wong E.Y., Pang S.M. and Johnston J.M., Health protection for Shenzhen residents: A tale of registrants and migrants (abstract and poster presentation), 16th Research Postgraduate Symposium on 7-8 December 2011 in Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2011, 4.10: 121.
McGhee S., Brazier J., Lam C.L.K., Wong L.C., Chau J., Cheung W.L. and Ho A.L.Y., Quality-adjusted life years: Population-specific measurement of the quality component, Hong Kong Medical Journal. 2011, 17(Suppl 6): S17-S21.
Zheng J., Wong M.C.M. and Lam C.L.K., Key factors associated with oral health-related quality of life (OHRQOL) in Hong Kong Chinese adults with orofacial pain, Journal of Dentistry. 2011, 39: 564-571.


Researcher : Lam CMJ
List of Research Outputs

Lai A.Y.K., Lam C.M.J., Svikis D.P., Fong D.Y.T. and Ip M.S.M., Self-efficacy predicts adherence to continuous positive airway pressure therapy in obstructive sleep apnea, American Thoracic Society International Conference, San Francisco, USA. 2012, Programme Book: p.A3846.
Lam C.M.J., Tan K.C.B., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea., Sleep Medicine. 2012, 13(1): 15-20.
Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).


Researcher : Lam KSL
Project Title:The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2006


Project Title:Adipocyte fatty acid binding protein as a novel mediator of obesity-related fatty liver disease
Investigator(s):Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones
Investigator(s):Lam KSL, Xu A, Wang Y, Tso AWK
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2010


Project Title:Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
Investigator(s):Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H., Lam K.S.L. and Xu A., Growth Hormone Induces Hepatic Production Of Fibroblast Growth Factor 21 Through A Mechanism Dependent On Lipolysis In Adipocytes., Journal of Biological Chemistry. 2011, 286: 34559-66.
Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H.Y., Lam K.S.L. and Xu A., Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes., J Biol Chem. 2011, 286: 34559-66.
Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012.
Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012.
Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Cheng K.Y., Lam K.S.L. and Xu A., The E3 ligase TRAF6 regulates the insulin-sensitizing actions of the adaptor protein APPL1 through ubiquitination., Ubiquitin and ubiquitin like modifiers, 2011. . 2011.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene , Eur J Endocrinol. 2011, 165(4): 571-7.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese, American Journal of Hypertension 2011. 2011, 24 (12): 1331-1337.
Cheung S.S.F., Leung J.W.C., Lam A.K.M., Lam K.S.L., Chung S.S.M., Lo A.C.Y. and Chung S.K., Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina, PLoS One . 2011, 6(10: e26184.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Chow W.S., Yuen M.A.M., Tso A.W.K., Fong H.Y., Lo S.V., Lam K.S.L. and Cheung B.M.Y., Non-traditional biomarkers in the prediction of cardiovascular events among Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 20.
Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Hoo R.L.C., Lee P.C., Cheng K.Y., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein mediates toxic-lipids-induced endoplasmic reticulum stress through inhibition of JAK-dependent autophagy, 7th International Symposium on Heathy Aging "Live Well Age Well", Research Centre of Heart, Brian, Hormone & Healthy Aging.. 2012.
Hoo R.L.C., Lee P.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via its inhibition of autophagy, 17 th Medicial Research Conference. 2012.
Hoo R.L.C., Wong J.Y., Qiao C., Xu H., Xu A. and Lam K.S.L., An effective fraction isolated from Radix Astragali alleviates glucose tolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, The 5th International Conference on Diabetes, Teaching Hospital of Chengdu Unviersity of Traditional Chinese Medicine. 2012.
Hoo R.L.C., Wong J.Y., Lam K.S.L. and Xu A., The Role of Adipocyte Fatty Acid Binding Protein (A-FABP) in the Pathogenesis of Obesity-related Inflammatory Diseases. , Sixth International Symposium on Healthy Aging, 2011.. 2011.
Hui X., Zhang M., Lam K.S.L. and Xu A., Adipocyte-Selective Disruption of SIRT1 Accelerates High Fat Diet and Aging induced Systemic Insulin Resistance via Modulation of Macrophage Infiltration and Polarization, 7th International Symposium on Healthy Aging. 2012.
Hui X., Lam K.S.L. and Xu A., Adipocyte-selective disruption of SIRT1 accelerates high fat diet and aging induced insulin resistance by modulation of macrophage infiltration and polarization, 17th Medical Research Conference. 2012.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update., Br J Pharmacol. 2012, 165(3): 574-90.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update, British Journal of Pharmacology. 2012, 165: 574-590.
Ji Y., Sun S., Xu A., Bhargava P., Yang L., Lam K.S.L., Gao B., Lee C.H., Kersten S. and Qi L., Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity, J Biol Chem. 2012, 287(17): 13561-71.
Lee C.H., Yuen M.M.A., Chow W.S., Tso A.W.K., Yeung C.K., Chan J.C.Y., Chau C.H. and Lam K.S.L., A man with a blistering eruption and tuberculosis, BMJ. 2012, 344: d8351.
Lee P.C.H., Chow W.S., Yuen M.A.M., Tso A.W.K., Xu A., Law S.C., Cheung S.C.W., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin levels are predictive of carotid intima-medial thickness in a 5-year community-based prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 32.
Leung T.M., Khong P.L. and Lam K.S.L., Prevalence and factors associated with brown adipose tissue detected by 18F-FDG PET/CT in Hong Kong Chinese, 16th Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong, 7-8 December, 2011.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Li H., Kilpelainen T.O., Liu C., Zhu J., Liu Y., Hu C., Yang Z., Zhang W., Bao W., Cha S., Wu Y., Yang T., Sekine A., Choi B.Y., Yajnik C.S., Zhou D., Takeuchi F., Yamamoto K., Chan J.C., Mani K.R., Been L.D., Imamura M., Nakashima E., Lee N., Fujisawa T., Karasawa S., Wen W., Joglikar C.V., Lu W., Chang Y., Xiang Y., Gao Y., Liu S., Song Y., Kwak S.H., Shin H.D., Park K.S., Fall C.H.D., Kim J.Y., Sham P.C., Lam K.S.L., Zheng W., Shu X., Deng H., Ikegami H., Krishnaveni G.V., Sanghera D.K., Chuang L., Liu L., Hu R., Kim Y., Daimon M., Hotta K., Jia W., Kooner J.S., Chambers J.C., Chandak G.R., Ma R.C., Maeda S., Dorajoo R., Yokota M., Takayanagi R., Kato N., Lin X. and Loos R.J.F., Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551East and South Asians, Diabetologia . 2012, 55(4): 981-95.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgrad Med . 2011, 123(6): 66-71.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgraduate Medicine. 2011, 123(6): 66-71.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure, Clinical and Experimental Hypertension 2011. 2011, 33 (7): 484-491.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac Adiponectin content and reduce myocardial reperfusion injury In diabetic rats , PLoS ONE. 2011, 6(8): e23967.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Ng J.K.F., Xu A., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats, PLoS One. 2011, 6(8): e23967.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and Chronic Liver Diseases: an Update, Adiponectin: Production, Regulation and Roles in Disease. NOVA SCIENCE PUBLISHERS, INC., 2011.
Wong T.W., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee V.W.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARgmediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.
Xiao Y., Xu A., Law S.C., Chen C., Li H., Li X., Yang L., Liu S., Zhou Z. and Lam K.S.L., Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes, J Clin Endocrinol Metab. 2012, 97(1): E54-8.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.
Yu H.Y., Woo J., Chan R., Sham A., Ho S., Tso A.W.K., Cheung B.M.Y., Lam T.H. and Lam K.S.L., Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey, Public Health Nutrition 2011 . 2011, 14 (7): 1133-1141.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.
Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Lam MF
List of Research Outputs

Chan G.S.W., Kwok J.S.Y., Lam M.F., Chan D.T.M. and Chan K.W., Renal allograft tissue: its new role in patient management, Histopathology. 2012, 60(7): 1160-2.
Lai K.N., Lam M.F., Leung J.C.K., Chan Y.Y., Lam C.W., Chan I.H., Chan H.W., Li C.S., Wong S.S., Ho Y.W., CHEUK A., Tang M.K. and Tang S.C.W., A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products, Peritoneal Dialysis International. 2011, 32(3): 280-91.
Leung J.C.K., Chan Y.Y., Tang S.C.W., Lam M.F., Chow C.W., Lim A.I. and Lai K.N., Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone, Journal of Translational Medicine. 2011, 9: 169-183.
Leung J.C.K., Chan Y.Y., Lam M.F., Tang S.C.W., Chow C.W., Lim A.I. and Lai K.N., The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid, Nephrology Dialysis Transplantation ePub. 2012.
Lim A.I., Chan Y.Y., Lai K.N., Tang S.C.W., Chow C.W., Lam M.F. and Leung J.C.K., Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells, International Journal of Biochemistry and Cell Biology . 2012, 44: 1040-1050.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.


Researcher : Lam SK
Project Title:Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):Lam SK
Department:Medicine
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:07/2003


Project Title:Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):Lam SK, Wong BCY, Lin MC
Department:Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2004




Researcher : Lam SK
Project Title:14th World Conference on Lung Cancer Antiproliferative Effect of Arsenic Trioxide in Non-Small Cell Lung Carcinoma (NSCLC)
Investigator(s):Lam SK
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2011
Completion Date:07/2011


List of Research Outputs

Lam S.K., Zheng C. and Ho J.C.M., Antiproliferative Effect of Arsenic Trioxide in Non-Small Cell Lung Carcinoma (NSCLC). 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S932 (P2.022).
Zheng C., Lam S.K. and Ho J.C.M., In-vitro Study of Arsenic Trioxide and Chemotherapeutic Agents in Small Cell Lung Carcinoma. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S933 (P2.023).


Researcher : Lam TP
Project Title:Attitudes, beliefs and knowledge concerning antibiotic use and resistance of the general public in Hong Kong: combined qualitative and quantitative study
Investigator(s):Lam TP, Lam KF, Ho PL
Department:Med - Family Medicine Unit
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:08/2009


Project Title:Primary care physicians’ attitudes towards people with mental health problems in Hong Kong
Investigator(s):Lam TP, Lam KF, Lam WW
Department:Med - Family Medicine Unit
Source(s) of Funding:Small Project Funding
Start Date:12/2009


Project Title:What are the facilitators and obstacles to promote mental health help-seeking in primary care? – views of family physicians and psychiatrists
Investigator(s):Lam TP, Lo TL, Lam KF
Department:Med - Family Medicine Unit
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:19th Wonca Asia Pacific Regional Conference The Public's Perspectives on Antibiotics Resistance and Abuse among Chinese in Hong Kong
Investigator(s):Lam TP
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012


Project Title:What are the barriers and facilitators to undertaking continuing professional education among private non-specialist primary care practitioners in Hong Kong?
Investigator(s):Lam TP, Lam KF
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Lam T.P., Co-Editor of Asia Pacific Family Medicine-the Official Journal of Wonca Asia Pacific. 2012.
Lam T.P., Member of the Editorial Board, Biomed Central Family Practice. 2012.
Lam T.P., Regional Editor of Journal of Evaluation and Clinical Practice. 2012.


Researcher : Lam WK
List of Research Outputs

Lam C.L.D., Girard L., Beer D.G., Gerald W.L., Kris M., Sihoe A.D.L., Cheng L.C., Wong M.P., Chung L.P., Ip M.S.M., Lam W.K., Gazdar A.F., Wistuba I.I. and Minna J.D., Expression of LATS2 and STK17B distinguishes epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 from those in 18 and 20 in lung adenocarcinomas, World Congress of Lung Cancer 2011.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.


Researcher : Lam YM
List of Research Outputs

Stolen C.M., Siu D.C.W., Lam Y.M. and Tse H.F., Pacing to reduce angina in patients with severe coronary artery disease. , J Cardiovasc Transl Res. . 2012, 5: 84-91.


Researcher : Lan HY
Project Title:Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Sun Chieh Yeh Heart Foundation - General Award
Start Date:08/2006


Project Title:Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Baxter Health Care Ltd. - General Award
Start Date:05/2008


Project Title:Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2008


List of Research Outputs

Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.


Researcher : Lan XR
Project Title:Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):Lan XR, Lan HY, Leung JCK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008




Researcher : Lau CP
Project Title:Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):Lau CP, Lee KLF
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:05/2000


Project Title:Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):Lau CP, Yu CM, Lan HY
Department:Medicine
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


List of Research Outputs

Chan H.T., So L.T., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation. , J Cardiovasc Pharmacol 2011. 2011, 58: 87-90.
Chan S.S.C., Leung D.Y.P., Wong C.N., Lau C.P., Wong V.T. and Lam T.H., A randomized controlled trial of stage-matched intervention for smoking cessation in cardiac out-patients, Addiction. 2012, Apr; 107(4): 829-37.
Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chan Y.H., Li S.W., Lam T.H., Lau C.P. and Tse H.F., Best Original Research by Trainees Silver Medal 2011 (Abstract titled: PR Interval Prolongation is Associated with Endothelial Dysfunction, Arterial stiffness and Activation of Vascular Repair: Novel Pathophysiological Insights and Clinical Implications), Hong Kong Academy of Medicine. Hong Kong, Hong Kong Academy of Medicine, 2011.
Chan Y.H., Siu D.C.W., Yiu Y.F., Yiu K.H., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR Prolongation is Associated with Endothelial Dysfunction and Vascular Repair Activation in High Risk Cardiovascular Patients, American Heart Association Scientific Session, Orlando. 2011.
Chan Y.H., Siu C.W., Yiu Y.F., Yiu K.H., Li S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is associated with endothelial dysfunction and activation of vascular repair in high risk cardiovascular patients (abstract and oral presentation), Circulation Supplement 1: American Heart Association Scientific Sessions 2011, 12-16 November 2011, Orlando, USA. 2011, 124 (Suppl 1): Abstract 8488.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.
Siu D.C.W., Tse H.F. and Lau C.P., A shock in time saves ablation?, Europace. 2011, 13: 155-6.
Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Thromboprophylaxis in patients with acute atrial fibrillation. , Acute Cardiac Care. . 2011.
Wang M., Yan G.H., Yue W.S., Siu D.C.W., Lee S.W.L., Lau C.P. and Tse H.F., Effects of low right atrial septal versus right atrial appendage pacing on atrial mechanical function in patients with sinus node dysfunction and atrial fibrillation. , Europace. 2012.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.
Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients after elective percutaneous coronary intervention. , Cardiovasc Diabetol.. 2011, 10: 52.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.


Researcher : Lau G
Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK
Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK
Project Title:Cytochrome P450 polymorphisms and clopidogrel resistance in Chinese with ischaemic stroke
Investigator(s):Lau GKK, Chan KH, Siu DCW, Tse HF, Cheung BMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:12/2011


Project Title:American Academy of Neurology 2012 - 64th Annual Meeting Viral Encephalitis in Hong Kong - A Hospital-Based Study
Investigator(s):Lau GKK
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2012
Completion Date:04/2012


List of Research Outputs

Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
Lau G.K.K., Lam F.M., Fung S.L. and Wong C.F., A middle-aged man with a painful muscular mass, QJM. 2012, Epub ahead of print.
Lau G.K.K., Fung S.L. and Wong C.F., A young man with a sudden 'white out' of right hemithorax on chest radiograph, QJM. 2012, Epub ahead of print.
Lau G.K.K., Yue W.S., Yiu K.H., Siu D.C.W., Wang M.M., Yan G.H. and Tse H.F., Best Abstract in Basic Science & Translational: Impact of Glycaemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2012.
Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Wong Y.K., Yiu K.H., Siu D.C.W. and Tse H.F., Prognostic implications of non-invasive vascular markers in patients with type 2 diabetes - a 5 year prospective study , Seventh International Symposium on Healthy Aging. 2012.
Lau G.K.K., Surrogate Markers of Atherosclerosis in Research of Cardiovascular Diseases, Institute of Cardiovascular Science and Medicine, The University of Hong Kong. 2012.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M., Yan G.H., Yiu K.H. and Tse H.F., Impact of Glycemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus , Cardiovascular Diabetology. 2011, 10(1):113.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M.M., Yan G.H., Yiu K.H. and Tse H.F., Impact of glycaemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18: 63.


Researcher : Lau KS
List of Research Outputs

Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.
Xiao S., Kung A.W.C., Gao R.Y., Lau K.S., Ma C.H., Zhang Z.L., Liu J.M., Xia W., He J.W. and Zhao L., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density, Human Molecular Genetics. 2011.


Researcher : Lau KW
List of Research Outputs

Lau K.W., Chan C.H., Law A.C.K., Ip M.S.M. and Mak J.C.W., The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells, Toxicol Sci. 2012, 125(2): 569-577.
Lau K.W., Chan M.M.W., Yip B.H.K., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 31.
Lau K.W., Chan M.M.W., Yip B.H., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, PLoS One. 2012, 7(2): e31617.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.


Researcher : Lau VYM
List of Research Outputs

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Lau WCS
Project Title:Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:01/1993


Project Title:Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):Lau WCS, Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):Lau WCS, Chan YTE, Cheung BMY
Department:Medicine
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2005


Project Title:Evaluation of the effects of micro-RNA146a on the function of bone marrow dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Travel Grants for NSFC/RGC JRS
Start Date:12/2009


Project Title:Characterisation of the features and functional changes of bone marrow dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2010


Project Title:Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Chan V.S.F., Nie Y.J., Shen N., Yan S., Mok T.M.Y. and Lau W.C.S., Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus, Autoimmunity Reviews. 2012, Epub ahead of print.
Chung H.Y., Lau W.C.S., Wu K.P., Wong R.W.S. and Mok T.M.Y., Comparison of performance of the Assessment of Spondyloarthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis., Clinical Rheumatology . 2011, 30(7): 947-953.
Lau W.C.S., Cardiovascular Complications in Rheumatic Diseases, 2012 Annual Scientific Conference of Jiangsu Society for Rheumatology, Xuzhou, China. 2012.
Lau W.C.S., Cardiovascular Complications of Rheumatic Diseases., Shenzhen, Dongguan, Huizhou Rheumatology Scientific Forum, Shenzhen, China.. 2011.
Lau W.C.S., Cardiovascular disease in systemic lupus erythematosus, Pathology Update, The Royal College Pathologists of Australasia (RCPA), Sydney. 2012.
Lau W.C.S., Dendritic cells and autoimmune diseases, HKU & Chinese Academy of Medical Sciences 1st Joint Symposium in Translational Medicine, Beijing, China. 2012.
Lau W.C.S., Managing Musculoskeletal Diseases in Asia, MSD Musculoskeletal Scientific Symposium, Hong Kong. 2012.
Lau W.C.S., Neuropsychiatric lupus – how much do we know? , Pathology Update, The Royal College Pathologists of Australasia (RCPA), Sydney. 2012.
Lau W.C.S., Option 2: Case study: Optimizing management of ankylosing spondylitis. , Pfizer Asia REACH Symposium: Targeting the future, Singapore. . 2011.
Lau W.C.S., Pathogenesis of systemic lupus erythematosus update, Pathology Update, The Royal College Pathologists of Australasia (RCPA), Sydney. 2012.
Lau W.C.S. and Cheung T.T., Should clinicians start measuring flow mediated dilation response in patients with systemic lupus erythematosus? , The Journal of Rheumatology. 2011, 38(7): 1231-1233.
Lau W.C.S., The pathogenic role of dendritic cells in systemic lupus erythematosus, The Chinese Rheumatology Association Annual Scientific Meeting, Kunming, China. 2012.
Lau W.C.S., Trial and registry data on TNF inhibitors and their implications for clinical practice in Asia., Pfizer Asia REACH Symposium: Targeting the future, Singapore.. 2011.
Li R., Yang W., Zhang J., Hirankarn N., Pan H.F., Mok C.C., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Lee T.L., Ho M.H.K., Lee P.P.W., Chan T.M., Wong W.H.S., Wong C.M., Ng I.O.L., Yang J., Li P.H., Zhang Y., Zhang L., Li W., Baum L., Kwan P., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S., Shen N., Lau Y.L. and Ye D.Q., Association of CD247 with systemic lupus erythematosus in Asian populations, Lupus. 2012, 21(1): 75-83.
Roux C., Reid D.M., Devogelaer J., Saag K.G., Lau W.C.S., Reginster J.L., Papanastasiou P., Su G., Bucci-Rechtweg C. and Sambrook P.N., Post-hoc analysis of a Single IV Infusion of Zoledronic Acid Versus Daily Oral Risedronate on Lumbar Spine Bone Mineral Density in Different Subgroups With Glucocorticoid-induced Osteoporosis, Osteoporosis International. 2012, 23(3): 1083-1090.
Sambrook P.N., Roux C., Devogelaer J.P., Saag K., Lau W.C.S., Reginster J.Y., Bucci-Rechtweg C., Su G. and Reid D.M., Bisphosphonates and glucocorticoid osteoporosis in men: results of a randomized controlled trial comparing zoledronic acid with risedronate, Bone. 2012, 50(1): 289-295.
Yang M., Deng J., Liu Y., Ko K.H., Wang X., Jiao Z., Wang S., Hua Z., Sun L., Srivastava G., Lau W.C.S., Cao X. and Lu L., IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation, The American Journal of Pathology. 2012, 180(6): 2375-85.
Yiu K.H., Tse H.F., Mok T.M.Y. and Lau W.C.S., Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. , Nat Rev Rheumatol.. 2011, 7: 609-18.


Researcher : Law SC
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Lee P.C.H., Chow W.S., Yuen M.A.M., Tso A.W.K., Xu A., Law S.C., Cheung S.C.W., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin levels are predictive of carotid intima-medial thickness in a 5-year community-based prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 32.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.
Xiao Y., Xu A., Law S.C., Chen C., Li H., Li X., Yang L., Liu S., Zhou Z. and Lam K.S.L., Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes, J Clin Endocrinol Metab. 2012, 97(1): E54-8.


Researcher : Lee PC
List of Research Outputs

Hoo R.L.C., Lee P.C., Cheng K.Y., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein mediates toxic-lipids-induced endoplasmic reticulum stress through inhibition of JAK-dependent autophagy, 7th International Symposium on Heathy Aging "Live Well Age Well", Research Centre of Heart, Brian, Hormone & Healthy Aging.. 2012.
Hoo R.L.C., Lee P.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via its inhibition of autophagy, 17 th Medicial Research Conference. 2012.


Researcher : Lee SWL
List of Research Outputs

Wang M., Yan G.H., Yue W.S., Siu D.C.W., Lee S.W.L., Lau C.P. and Tse H.F., Effects of low right atrial septal versus right atrial appendage pacing on atrial mechanical function in patients with sinus node dysfunction and atrial fibrillation. , Europace. 2012.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.


Researcher : Lee TMC
Project Title:Selective attention biases of people with major depressive disorder, and its relationship with brain damages.
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:A post-discharge service for brain injury patients in Central and Western District
Investigator(s):Lee TMC, Chan SSC, Hung KN, Li LSW, Leung KK
Department:Psychology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:12/2006


Project Title:Cognitive Dysfunction after Anesthesia (CoDA) Study
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2007


Project Title:Research Output Prize (Faculty of Social Sciences)
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:11/2007


Project Title:Effects of moods on risk-taking behavior: cognitive and neural mechanisms
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Travel Grants for NSFC/RGC JRS
Start Date:12/2007


Project Title:The Brain Mechanisms to Use Electronic "Bat Ears" to Replace Vision: From Human to Animal Users
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2010


Project Title:The neural basis of processing of negative-affect stimuli in domestic violence offenders
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Incentive Award for RGC GRF Fundable But Not Funded Projects
Start Date:07/2010
Completion Date:08/2011


Project Title:Memory and attention training to reduce the risk of developing dementia
Investigator(s):Lee TMC, Chu LW, Hou WK
Department:Psychology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Modality-specific neural effects of meditation
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011
Completion Date:12/2011


Project Title:The neural effect of focused-attention meditation and loving-kindness meditation on attention and emotion perception
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Incentive Award for RGC GRF Fundable But Not Funded Projects
Start Date:07/2011


Project Title:Mild Cognitive Impairment (MCI), The Annual Cognitive Neuroscience Conference Neural activity assocaited with viewing emotional faces by people with Alzheimer's Disease
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2012
Completion Date:03/2012


Project Title:Effects of an auditory-based cognitive training program on attention and memory of older people at risk of progressive cognitive decline: A randomized controlled trial
Investigator(s):Lee TMC, Chu LW, Tam HMK
Department:Psychology
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:04/2012


List of Research Outputs

Yau S.Y., Zhang E., Lee C.D., Lee T.M.C. and So K.F., Pre-running Reduces Depression-like Behavior and Restores Hippocampal Neurogenesis in Rats with Severe Stress, The 6th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry - Consciousness, Neuroimaging & Neuro-psychiatry. 2012, 24.


Researcher : Lee YK
List of Research Outputs

Lee Y.K., Asia Outstanding Graduate Thesis Award in Bio-tech, Johnson & Johnson Services, Inc (“JJSI”). 2012.
Lee Y.K. and Siu D.C.W., Calcium Handling in hiPSC-derived Cardiomyocytes., SpringerBrief. 2012.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Lee Y.K., Mary Sun Medical Scholarship (Postgraduate), HSBC Trustee (Hong Kong) Limited. 2012.
Lee Y.K., Travel Award in ISSCR 10th Annual Meeting in Yokohama, Japan, 2012, International Society of Stem Cell Research (ISSCR). 2012.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Lee YK
List of Research Outputs

Lee Y.K., Asia Outstanding Graduate Thesis Award in Bio-tech, Johnson & Johnson Services, Inc (“JJSI”). 2012.
Lee Y.K. and Siu D.C.W., Calcium Handling in hiPSC-derived Cardiomyocytes., SpringerBrief. 2012.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Lee Y.K., Mary Sun Medical Scholarship (Postgraduate), HSBC Trustee (Hong Kong) Limited. 2012.
Lee Y.K., Travel Award in ISSCR 10th Annual Meeting in Yokohama, Japan, 2012, International Society of Stem Cell Research (ISSCR). 2012.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Leung AYH
Project Title:Provision of free alemtuzumab (anti-CD52) to patients with chronic lymphocytic leukemia refractory to conventional chemotherapy
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2007


Project Title:Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):Leung AYH, Kwong YL, Tang SCW
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Is Jak2V617F mutation a stem cell event in chronic myeloproliferative disease ?
Investigator(s):Leung AYH, Liang RHS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:12/2011


Project Title:Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2009


Project Title:Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2010


Project Title:Is aldehyde dehydrogenase a negative regulator of primitive hematopoiesis during embryonic development?
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Study of Microglia and Acute Myeloid Leukemia in Zebrafish
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:05/2010


Project Title:A novel role of methionine aminopeptidase 2 (MetAP-2) in the regulation of hematopoietic stem cell during definitive hematopoiesis
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010


Project Title:Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Is sox7 a tumour suppressor in acute myeloid leukemia?
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.C., Leung A.Y.H., Wong A.S., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft patients, Renal Failure . 2012, 34: 550-554.
Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chan T.S., Gill H., Leung A.Y.H., Chan W.M., Khong P.L. and Kwong Y.L., Uveitis as the initial manifestation of diffuse large B-cell lymphoma, American Journal of Hematology . 2012, 87(2): 198-200.
Chung I.S., Ma C.H., Fung T.K. and Leung A.Y.H., Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis , Experimental Hematology. Elsevier, 2011.
Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.
Lee E.Y.P., Anthony M., Leung A.Y.H., Loong F. and Khong P.L., Utility Of FDG PET/CT In The Assessment Of Myeloid Sarcoma, AJR, American Journal of Roentgenology. 2012.
Ma C.H., Chung I.S., Lin H., Yang D., Liang R.H.S. and Leung A.Y.H., Methionine aminopeptidase 2 (MetAP2) is required for zebrafish hematopoietic stem cell initiation, 7th European Zebrafish Meeting. 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.
Ma C.H., He B., Guo Y. and Leung A.Y.H., Modeling Tumor Angiogenesis with Zebrafish, In: Dan T. Simionescu and Agneta Simionescu, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medicine. Rijeka Croatia, Intech, 2011, 133-144.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.
Tse E.W.C., Leung A.Y.H., Sim P.Y.J., Lee H.K., Liu H.S., Yip S.F. and Kwong Y.L., Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia., ANNALS OF HEMATOLOGY. 2011, 90(11): 1277-81.


Researcher : Leung JCK
Project Title:Infiltrating leukocytes in the tubulointerstitium of IgA nephropathy: Their role in pathogenesis
Investigator(s):Leung JCK, Lai KN
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Renin-angiotensin system within the podocytes in IgA nephropathy
Investigator(s):Leung JCK, Lai KN
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


List of Research Outputs

Lai K.N., Lam M.F., Leung J.C.K., Chan Y.Y., Lam C.W., Chan I.H., Chan H.W., Li C.S., Wong S.S., Ho Y.W., CHEUK A., Tang M.K. and Tang S.C.W., A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products, Peritoneal Dialysis International. 2011, 32(3): 280-91.
Lai K.N., Tang S.C.W. and Leung J.C.K., Recent advances in IgA nephropathy - the glomerulopodocytic-tubular communication, Advances in Otorhinolaryngology. 2011, 72: 40-4.
Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in IgA nephropathy – the glomerulo-podocytic-tubular communication, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 72: 40-44.
Leung J.C.K., Chan Y.Y., Tang S.C.W., Lam M.F., Chow C.W., Lim A.I. and Lai K.N., Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone, Journal of Translational Medicine. 2011, 9: 169-183.
Leung J.C.K., Chan Y.Y., Lam M.F., Tang S.C.W., Chow C.W., Lim A.I. and Lai K.N., The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid, Nephrology Dialysis Transplantation ePub. 2012.
Lim A.I., Chan Y.Y., Lai K.N., Tang S.C.W., Chow C.W., Lam M.F. and Leung J.C.K., Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells, International Journal of Biochemistry and Cell Biology . 2012, 44: 1040-1050.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents Against IgA Nephropathy, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 45-49.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents against IgA Nephropathy, Advances in Otorhinolaryngol. 2011, 72: 45-9.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.


Researcher : Leung RCY
List of Research Outputs

Chiu J., Tang Y.F., Yao T.J., Wong A., Wong H., Leung R.C.Y., Chan P., Cheung T.T., Chan A.C.Y., Pang R.W.C., Fan S.T., Poon R.T.P. and Yau T.C.C., The use of single-agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child-Pugh B liver cirrhosis: A retrospective analysis of efficacy, safety, and survival benefits, Cancer. 2012, Epub on 2012-04-19.
Law M., Ma W.H., Leung R.C.Y., Li S., Wong K.K., Ho W.Y. and Kwong A., Evaluation of patient effective close from sentinel lymph node lymphoscintigraphy in breast cancer: A phantom study with SPECT/CT and ICRP-103 recommendations, European Journal of Radiology. 2012, Epub ahead of print.
Wong H., Lau S., Leung R.C.Y., Chiu J., Cheung P., Wong T.T., Liang R., Epstein R.J. and Yau T.C.C., Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer, Medical Oncology. 2011, Epub on 2011-10-08.
Wong H., Tang Y.F., Yao T., Chiu J., Leung R.C.Y., Chan P., Cheung T.T., Chan A.C.Y., Pang R.W.C., Poon R.T.P., Fan S.T. and Yau T.C.C., The outcomes and safety of single-agent sorafenib in the treatment of elderly patients with advanced hepatocellular carcinoma (HCC), Oncologist. 2011, 16(12): 1721-1728.


Researcher : Leung WK
Project Title:Molecular characterization of bacterial microbiota in the stomach of patients with H. pylori infection
Investigator(s):Leung WK, Woo PCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:09/2011


List of Research Outputs

Leung W.K., 13th Annual Scientific Meeting of the Hong Kong Society of Gastrointestinal Motility. 2011.
Leung W.K., Case study on SB and COLON, Capsule Endoscopy Workshop, organized by Given Imaging, Singapore. 2012.
Leung W.K., Colorectal Cancer Screening, Multi-specialty Medial Mega Conference (M3C 2.0) organized by the Private Medical Specialists of Hong Kong. 2012.
Leung W.K., Hands On Session, Capsule Endoscopy Workshop, organized by Given Imaging, Singapore. 2012.
Leung W.K., IBD Treatment in Hong Kong, IBD Network, Seoul, Korea. 2011.
Leung W.K., Suen B.Y., Chan F.K.L. and Lau J.Y., Immediate capsule endoscopy or angiogram in patients with acute obscure gastrointestinal bleeding: A prospective randomized study with long term follow up, Digestive Disease Week, San Diego, USA. 2012.
Leung W.K., Inflammatory bowel disease in Asia, 2012 Sothern Digestive Disease Forum and 8th National Academic Congress on Intestinal Diseases, Guangzhou, China. 2012.
Leung W.K., Ho S.S.M., Suen B.Y., Lai L.H., Yu S., Ng E.K.W., Ng S.S.M., Chiu P.W.Y., Sung J.J.Y., Chan F.K.L. and Lau J.Y.W., Long term follow up of patients with acute overt obscure gatrointestinal bleeding randomized to capsule endoscropy or angiogram, United European Gastroenterology Week, 22-26 Oct 2012 in Stockholm. 2011.
Leung W.K., Novel Medical Treatment for GERD, Foregut Disorders Workshop organized by the Hong Kong Society of Upper Gastrointestinal Surgeons. 2012.
Leung W.K., Overview of inflammatory bowel disease in Asia, 2012 International Exchange Summit on Digestive and Anorectal Diseases, Yangzhou, China. 2012.
Leung W.K., Pillcam Colon and SB2, The 4th Shanghai International Pancreatology Forum & 14th National Academic Endoscopic Ultrasound Conference, Shanghai, China. 2011.
Leung W.K., Reading technique on Pill Cam COLON 2, Capsule Endoscopy Workshop, organized by Given Imaging, Singapore. 2012.
Leung W.K., Screening for colorectal cancer: Which test to choose, 17th Hong Kong Medical Forum organized by HKU. 2012.
Leung W.K., Timing and Positions of Biologics in IBD, Macau IBD Round Table, Macau. 2012.
Leung W.K., Tang V. and Lui P.C.W., Timing of bowel preparation and colonoscopy on colonic preparation and polyp detection: a single endoscopist study, J Gastroen Hepatol. 2011, 26 Supplement 5: 124.


Researcher : Leung YH
List of Research Outputs

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene , Eur J Endocrinol. 2011, 165(4): 571-7.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese, American Journal of Hypertension 2011. 2011, 24 (12): 1331-1337.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Anti-obesity drugs-are they underused in the United States?, Journal of the Hong Kong College of Cardiology. Presented at the Fifteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong 2011. 19 (2): 69.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007-2008, Annals of Epidemiology. 2012, 22 (5): 349-53.


Researcher : Li C
List of Research Outputs

Cheung B.M.Y. and Li C., Diabetes and hypertension: is there a common metabolic pathway?, Current Atherosclerosis Reports. 2012, 14 (2): 160-6.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 36.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The Relationship between Waist Circumference and Glycated Hemoglobin in the United States, Journal of the Hong Kong College of Cardiology. Presented at the Twentieth Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong, May 2012. 20 (Suppl 1): A1.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between A1C and waist circumference in the US population, XVI International Symposium on Atherosclerosis 2012, Sydney. 2012.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between glycated haemoglobin and waist circumference in the US population, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 43.


Researcher : Li FYL
List of Research Outputs

Baretella O.M., Li F.Y.L., Chung S.K. and Vanhoutte P.M.G.R., Reduction of contractions to phenylephrine by L-NAME in the carotid artery of mice with endothelial overexpression of endothelin-1, Experimental Biology 2012, April 21 - 25, 2012, San Diego, CA . 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Li J., Li F.Y.L., Xu A., Cheng B., Tsao G.S.W., Fung M.L. and Leung W.K., Lipopolysaccharide and Hypoxia Induce HIF-1 Activation in Human Gingival Fibroblasts, Journal of Periodontology. 2011, 1-8.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.


Researcher : Li G
Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts
Investigator(s):Li GR, Lau CP, Lee HC, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives
Investigator(s):Li GR, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:03/2010
Completion Date:08/2011


Project Title:Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:09/2011


Project Title:56th Annual Meeting of Biophysical Society TRPC1 CHANNELS MEDIATE THE NONSELECTIVE CATION CURRENT AND STORE-OPERATED CALCIUM CHANNELS IN HUMAN ATRIAL MYOCYTES
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2012
Completion Date:02/2012


Project Title:Demonstration of TRPM channels in human cardiac atrial myocytes
Investigator(s):Li GR, Li X
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012


List of Research Outputs



Researcher : Li GR
Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts
Investigator(s):Li GR, Lau CP, Lee HC, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives
Investigator(s):Li GR, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:03/2010
Completion Date:08/2011


Project Title:Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:09/2011


Project Title:56th Annual Meeting of Biophysical Society TRPC1 CHANNELS MEDIATE THE NONSELECTIVE CATION CURRENT AND STORE-OPERATED CALCIUM CHANNELS IN HUMAN ATRIAL MYOCYTES
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2012
Completion Date:02/2012


Project Title:Demonstration of TRPM channels in human cardiac atrial myocytes
Investigator(s):Li GR, Li X
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012


List of Research Outputs

Che H. and Li G.R., Effects of functional transient receptor potential channels on adipogenesis and proliferation in human preadipocytes, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 24.
Che H., Sun H. and Li G.R., Functional transient receptor potential channels in human cardiac c-kit cells, Hong Kong - Taiwan Physiology Symposium, June. 2012, 51.
Chen J., Liu W., Che H., Liu J., Sun H. and Li G.R., Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. , Br J Pharmacol. . 2012, 166(3): 1140-1150.
He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.
Li G.R., Advances in cardiac ion channels - from mouse to human, similarity and differences, 2011 Cardiovascular Physiology - Chinese Physiological Society. 2011.
Li G.R., 心臟離子通道研究的進展-從小鼠到人類，相似性與差異, CAPS News Communication. 2011, 30(2): 1-3.
Li G.R., Chairpersons, Symposium on Cardiovascular Physioligy of APS. 2011. Mianyang, China , 2011.
Li G.R., How many ion channels can be considered as the specific targets for developing atrial-selective anti-atrial fibrillation drugs, The 8th Scientific Conference On Cardiovascular Sciences Across The Strait. 2011.8.15-18, Yinchuan, China. Journal Of Ningxia Meical Niversity. 2011, 33: 24.
Li G.R., Sudden cardiac death and channelopathies, Luzhou Medical College, Sichuan, China. 2012.
Li G.R., 心臟離子通道研究的進展-從小鼠到人類，相似性與差異, Symposium on Cardiovascular Physioligy of APS. 2011. Mianyang, China . 2011.
Wang Y., Deng X.L. and Li G.R., Epidermal growth factor stimulates cell proliferation by activating voltage-gated potassium channels in rat bone marrow-derived mesenchymal stem cells, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H. and Li G.R., The in-vitro cardioprotective effect of the natural flavone acacetin against ischaemia/reperfusion injury in rat hearts, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 59.
Wu H., Wu W., Sun H. and Li G.R., The natural flavone acacetin blocks kv4.3 current by interacting with P-loop filter helix of the channel, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Li LSW
List of Research Outputs

Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chan Y.H., Siu D.C.W., Yiu Y.F., Yiu K.H., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR Prolongation is Associated with Endothelial Dysfunction and Vascular Repair Activation in High Risk Cardiovascular Patients, American Heart Association Scientific Session, Orlando. 2011.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Lam L.T., Zhang W.E.N., Samaranayake L.P., Li L.S.W. and McGrath C.P.J., A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease, International Journal of Cardiology. Elsevier, 2011, 151: 161-167.
Lam L.T., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Effectiveness of oral hygiene interventions against oral and oropharyngeal reservoirs of aerobic and facultatively anaerobic gram-negative bacilli, American Journal of Infection Control. 2012, 40: 175-182.
Lam L.T., McGrath C.P.J., Samaranayake L.P., Li L.S.W. and McMillan A.S., Oral interventions on opportunistic pathogens in patients following acute stroke , Journal of Dental Research. Sage, 2011, Vol. 90, Special Issue B: 98.


Researcher : Li M
List of Research Outputs

Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgrad Med . 2011, 123(6): 66-71.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgraduate Medicine. 2011, 123(6): 66-71.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.


Researcher : Li RA
Project Title:Non-cell autonomous directed maturation of developmentally arrested hESC/iPSC-derived cardiomyocytes
Investigator(s):Li RA
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Re-engineering Regenerative Medicine: Hong Kong as an Emerging Asian Hub for Biotech and Stem Cell-based Translations
Investigator(s):Li RA
Department:Medicine
Source(s) of Funding:General Support Programme
Start Date:08/2011
Completion Date:02/2012


Project Title:Cell-based Heart Regeneration
Investigator(s):Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:09/2011


List of Research Outputs

Kong M.C.W., Chen S., Geng L., Sun D. and Li R.A., Laser and chemical induced fusion to reverse engineer the physical size of hESC-derived CMs: a nongenetic approach for driven physiological hypertrophy and maturation., Days of Molecular Medicine 2011.
Li R.A., Chan C.W.Y., Kong M.C.W., Kenneth R. Boheler K.B., Ji-Dong Fu J.D.F., Stephanie N. Rushing, S.R., Deborah K. Lie D.L., Geng L., Kitchener D. Wilson K.W., Nipavan Chiamvimonvat N.C. and Joseph C. Wu J.W., Gordon Keller G.K., Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes., PloS One. 6(11):e27417.. 2011.
Li R.A., Engineering human heart cells and tissues, U of Waterloo Distinguished Alumni Series.. 2012.
Li R.A. and Poon N.Y.E., MicroRNA- and Pluripotent Stem Cell-based Heart Therapies: From the Electrophysiological Perspectives, Mol Pharm. 8(5):1495-504. PMID:21879736. 2011.
Li R.A., Pluripotent Stem Cell-based Heart Regeneration. Cardiovascular Center, UC Irvine. 2011.
Li R.A., Pluripotent Stem Cell-based Heart Regeneration. KI-Hong Kong Regenerative Medicine Workshop, Karolinska Institutet. 2011.
Li R.A., Pluripotent Stem Cell-based Heart Regeneration. UK-Hong Kong Frontiers of Science meeting, Royal Society Kavli centre. 2011.
Li R.A., Pluripotent Stem Cell-based Heart Regeneration. UK-Hong Kong Frontiers of Science meeting, Royal Society Kavli centre. 2011.
Li S., Yeung H.M., Kong M.C.W. and Li R.A., Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes., Days of Molecular Medicine, 2011.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Lui O.L.K., Bu L., Li R.A. and Chan C.W.Y., Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives. , Birth Defects Res C Embryo Today. 2012, 96.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Tso H.W., Yim L.Y., Lau K.L.K., Li R.A. and Chan C.W.Y., Distinct immunomodulatory effect of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells, Re-engineering Regenerative Medicine 2012. 2011.
Wang J., Lieu D.K., Karakikes I., Chen A., Turnbull I., Kong M.C.W., Hajjar R., Costa K., Khine M. and Li R.A., Engineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: An accurate arrhythmias model for cardiotoxicity screening., Days of Molecular Medicine, 2011.


Researcher : Li S
List of Research Outputs

Li S., Yeung H.M., Kong M.C.W. and Li R.A., Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes., Days of Molecular Medicine, 2011.


Researcher : Li X
List of Research Outputs

Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.


Researcher : Lian Q
Project Title:Generation of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering
Investigator(s):Lian Q, Tse HF, Wong DSH, Siu DCW, Yu CS
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2010
Completion Date:12/2011


Project Title:The Roles of Mesenchymal Stem Cell Produced Stromal Cell-derived Factor-1 and Neuregulin-1 for Cardiac Progenitor Cell-mediated Myocardial Regeneration in Response to Heart Infarction
Investigator(s):Lian Q, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2010


Project Title:Functional Characterization of human iPSC- derived mesenchymal stem cells with cardiomyocyte potential
Investigator(s):Lian Q, Tse HF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:16th WORLD CONGRESS ON HEART DISEASE ANNUAL SCIENTIFIC SESSIONS 2011 Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior to Adult Bone Marrow-derived Mesenchymal Stem Cells in the Treatment of Limb Ischemia Improved Cell Survival and Paracrine Capacity of Human Embryonic Stem Cells-Derived Mesenchymal Stem Cells Promotes Therapeutic Potential for Pulmonary Arterial Hypertension
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2011
Completion Date:07/2011


Project Title:The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


List of Research Outputs

Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Lian Q., Application of induced pluripotent stem cells in retinal degeneration , Karolinska Instisute (KI)-HKU Course for Nervous System Development,Hong Kong. April 26--‐27, 2012. 2012.
Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment of Limb Ischemia , The16th WORLD CONGRESS ON HEART DISEASE ANNUAL SCIENTIFIC SESSIONS . Conference invited speaker (23-27, July 2011, Vancouver, Canada): . 2011.
Lian Q. and Tse H.F., Human Induced Pluripotent Stem cells for Regenerative Medicine, The 2nd Hk-uk Frontiers Of Science Meeting (organized By The Royal Society, Uk And The Croucher Foundation, Hong Kong . London,5-8. September, 2011.. 2011.
Lian Q., Therapeutic potential of pluripotent stem cell-derived mescenchymal stem cells in cardiovascular regeneration, Invitation to 15th Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine 17 September 2011, Hong Kong Convention and Exhibition Centre. 2011.
Lian Q., Therapeutic potential of pluripotent stem cell-derived mescenchymal stem cells in cardiovascular regeneration, the 15th Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, 17 September 2011 at the Hong Kong Convention & Exhibition Centre.. 2011.
Ma Y.Y., Li C., Law C.F.B.C., Lian Q., Man K. and Lo C.M., 2012Young Investigator Travel Award , 18th International Liver Transplantation Society Congress,may 16 - 19, 2012 San Francisco, Californa, USA Novel Mechanism for Tissue Repair of Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells during Liver Regeneration . Liver Transplantation, 2012, 18.
Ma Y.Y., Li C.X., Law B., Lian Q., Man K. and Lo C.M., Novel Mechanism for Tissue Repair of Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells during Liver Regeneration, Liver Transplantation. 2012, 18: S138-S139.
Pan K., Liang X., Zhang H.K., Zhao J.J., Wang D.D., Lian Q., Chang A.E., Li Q. and Xia J.C., Characterization of BIN1 as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma., Mol Med. 2012, 18(1):507-18.
Wong Y.H.I., Poon M.W., Pang R.T.W., Lian Q. and Wong D.S.H., Promises of stem cell therapy for retinal degenerative diseases , Graefes Arch Clin Exp Ophthalmol. 2011, 249(10): 1439-48.
Wong Y.H.I., Poon M.W., Pang R.T., Lian Q. and Wong D.S.H., Promises of stem cell therapy for retinal degenerative diseases, Graefe's Archive of Clinical and Experimental Ophthalmology. 2011, 249 (10): 1439-1448.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.


Researcher : Liang RHS
List of Research Outputs

Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang J.C.O., Choi W.L., Liu W.P., Li G.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK, Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma, "Abstract Achievement Award" received by Dr. Yun-Wen Chen (Postdoctoral Fellow) for the presentation of the paper at the 53rd American Society of Hematology Annual Meeting and Exposition, San Diego, USA, December 10-13, 2011. 2011.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Au W.Y., Tao Q., Wong M.L.Y., Tang C.-.O., Choi W.L., Liu W.-.P., Li G.-.D., Shimizu N., Tsuchiyama J., Loong F., Liang R.H.S., Kwong Y.L. and Srivastava G., Epigenetic silencing of the receptor tyrosine phosphatase, PTPRK, located at the frequently deleted 6q22.33-q23.2 region, leads to tumor growth via the constitutive activation of STAT3 in nasal-type NK/T-Cell lymphoma, The 53rd American Society of Hematology Annual Meeting and Exposition. 2011.
Chim J.C.S., Lie A.K.W., Chan Y.E.T., Liu H.S.Y., Lau C.W., Yip S.Y., Sim J., Wan T.S.K., Ma E.S.K., Liang R.H.S., Tse E.W.C. and Kwong Y.L., Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD, Journal of Hematology and Oncology. 2012, 8;5(1): 28.
Ma C.H., Chung I.S., Lin H., Yang D., Liang R.H.S. and Leung A.Y.H., Methionine aminopeptidase 2 (MetAP2) is required for zebrafish hematopoietic stem cell initiation, 7th European Zebrafish Meeting. 2011.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.


Researcher : Liang X
List of Research Outputs

Pan K., Liang X., Zhang H.K., Zhao J.J., Wang D.D., Lian Q., Chang A.E., Li Q. and Xia J.C., Characterization of BIN1 as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma., Mol Med. 2012, 18(1):507-18.


Researcher : Liao S
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.


Researcher : Liao S
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.


Researcher : Lie AKW
List of Research Outputs

Chim J.C.S., Lie A.K.W., Chan Y.E.T., Liu H.S.Y., Lau C.W., Yip S.Y., Sim J., Wan T.S.K., Ma E.S.K., Liang R.H.S., Tse E.W.C. and Kwong Y.L., Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD, Journal of Hematology and Oncology. 2012, 8;5(1): 28.
Gill H., Cheung J., Wong Y.H.I., Lie A.K.W. and Kwong Y.L., Varicella zoster virus progressive outer retinal necrosis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2012, 157: 279.


Researcher : Lin H
List of Research Outputs

Ma C.H., Chung I.S., Lin H., Yang D., Liang R.H.S. and Leung A.Y.H., Methionine aminopeptidase 2 (MetAP2) is required for zebrafish hematopoietic stem cell initiation, 7th European Zebrafish Meeting. 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.


Researcher : Lin M
List of Research Outputs

Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Tang S.C.W., Lin M., Tam K.Y., Au W.S., Ma M.K., Ho W.Y. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrol. Dial. Transplant.. 2012, 27: 613-8.


Researcher : Liu H
Project Title:Phenotypic analysis of LRRK2 R1441G knockin mouse and the pathological role of LRRK2 R1441G mutation in neurodegeneration in Parkinson’s Disease
Investigator(s):Liu H, Ho SL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2011


List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.
Liu H., Travel Grant , the XIX World Congress on Parkinson's Disease and Related Disorders. 2011.
Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.


Researcher : Liu L
List of Research Outputs

Liu L., Siu A.F.M., Che C.M., Xu A. and Wang Y., Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins, American Journal of Translational Research. 2012, 4: 175-186.
Liu L. and Cheung R.T.F., Neuroprotection of melatonin and electro-acupuncture (EA) following focal cerebral ischemia in rats, Sixth International Symposium on Healthy Aging, Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012, 47.


Researcher : Liu L
List of Research Outputs

Liu L., Siu A.F.M., Che C.M., Xu A. and Wang Y., Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins, American Journal of Translational Research. 2012, 4: 175-186.
Liu L. and Cheung R.T.F., Neuroprotection of melatonin and electro-acupuncture (EA) following focal cerebral ischemia in rats, Sixth International Symposium on Healthy Aging, Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012, 47.


Researcher : Liu W
List of Research Outputs

Chen J., Liu W., Che H., Liu J., Sun H. and Li G.R., Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. , Br J Pharmacol. . 2012, 166(3): 1140-1150.
He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.


Researcher : Liu Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.


Researcher : Liu Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.


Researcher : Liu Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.


Researcher : Lo WK
List of Research Outputs

Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.


Researcher : Lui OLK
Project Title:Induction of transplantation tolerance to human pluripotent stem cell-derived tissues
Investigator(s):Lui OLK, Chan CWY, Li RA
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Lui O.L.K., Bu L., Li R.A. and Chan C.W.Y., Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives. , Birth Defects Res C Embryo Today. 2012, 96.


Researcher : Lui SL
List of Research Outputs

Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.
Yung S.S.Y., Ng K.F., Yim A.S.Y., Ma M., Lui S.L. and Chan D.T.M., Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate, Journal of the American Society of Nephrology. 2011.


Researcher : Luk JKH
List of Research Outputs

Chan T.C., Hung I.F.N., Luk J.K.H., Woo P.C.Y. and Chu L.W., Prevention Of Mortality And Pneumonia Among Nursing Home Older Adults By Dual Pneumococcal And Seasonal Influenza Vaccination During A Pandemic Caused By Novel Pandemic Influenza A (h1n1)., J Am Med Dir Assoc. 2012.


Researcher : Ma CH
List of Research Outputs

Chung I.S., Ma C.H., Fung T.K. and Leung A.Y.H., Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis , Experimental Hematology. Elsevier, 2011.
Ma C.H., Chung I.S., Lin H., Yang D., Liang R.H.S. and Leung A.Y.H., Methionine aminopeptidase 2 (MetAP2) is required for zebrafish hematopoietic stem cell initiation, 7th European Zebrafish Meeting. 2011.
Ma C.H., Fung T.K., Lin H., Chung I.S., Yang D., Ekker S.C. and Leung A.Y.H., Methionine aminopeptidase 2 is required for HSC initiation and proliferation, Blood. 2011, 118: 5458-5457.
Ma C.H., He B., Guo Y. and Leung A.Y.H., Modeling Tumor Angiogenesis with Zebrafish, In: Dan T. Simionescu and Agneta Simionescu, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medicine. Rijeka Croatia, Intech, 2011, 133-144.
Man C.H., Fung T.K., Ho C., Han H.H., Chow C.H., Ma C.H., Choi W.L., Lok S., Cheung A.M., Eaves C.J., Kwong Y.L. and Leung A.Y.H., Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation, Blood. 2012, 119: 5133-43.
Xiao S., Kung A.W.C., Gao R.Y., Lau K.S., Ma C.H., Zhang Z.L., Liu J.M., Xia W., He J.W. and Zhao L., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density, Human Molecular Genetics. 2011.


Researcher : Mak JCW
Project Title:Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):Mak JCW, Chan MMW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2005


Project Title:Effects of cigarette smoke on regulation of the expression of adiponectin and its receptors in airway cells
Investigator(s):Mak JCW, Ip MSM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Signaling pathways on intermittent hypoxia-induced oxidative stress in human EAhy 926 endothelial cell line
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011
Completion Date:06/2012


Project Title:Involvement of fatty acid-binding proteins in cigarette smoke-induced inflammatory responses in human airway epithelial cells
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Chan K.Y.C., Mak J.C.W., Gao Y.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology. 2011, 301: H2313-H2321.
Chan M.C.W., Chan W.Y., Mak J.C.W., Peiris J.S.M. and Nicholls J.M., The influence of smoking on pulmonary influenza infection an ex vivo study, XIV International Symposium on Respiratory Viral Infections.. 2012.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cellular mechanisms involved in intermittent hypoxia-induced heart damage in rat, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 23.
Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64.
Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752.
Lam J.C.M., Mak J.C.W. and Ip M.S.M., Obesity, obstructive sleep apnea and metabolic syndrome, Respirology. 2012, 17(2): 223-236.
Lau K.W., Chan C.H., Law A.C.K., Ip M.S.M. and Mak J.C.W., The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells, Toxicol Sci. 2012, 125(2): 569-577.
Lau K.W., Chan M.M.W., Yip B.H.K., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 31.
Lau K.W., Chan M.M.W., Yip B.H., Cheung A.H.K., Ip M.S.M. and Mak J.C.W., The role of circulating serotonin in the development of chronic obstructive pulmonary disease, PLoS One. 2012, 7(2): e31617.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.
Lui M.M.S., Tse H.F., Mak J.C.W., Lam J.C.M., Lam C.L.D., Tan K.C.B. and Ip M.S.M., Altered endothelial repair capacity in obstructive sleep apnea in relation to elevated advanced glycation endproducts., Asia Pacific Society of Respirology Annual Congress, Nov 2011, Shanghai.. 2011.
Mak J.C.W., Han Q., Yeung S.C. and Ip M.S.M., Effects of intermittent hypoxia on the expression levels of fatty acid-binding protein in rat heart, Am J Respir Crit Care Med. 2012, 185: A3869.
Mak J.C.W., Pathogenesis of COPD, 3rd Asia-Pacific Region Union Conference, Hong Kong. 2011.
Mak J.C.W., Potential role of green tea catechins in various disease therapies: progress and promise, Clin Exp Pharmacol Physiol. 2012, 39(3): 265-273.
Mak J.C.W., The use of intermittent hypoxia model in sleep apnea research, 16th Congress of the Asian Pacific Society of Respiratory (APSR) - Post-graduate Course "Sleep Apnea: from Bench to Bed", Shanghai, China. 2011.


Researcher : Mak W
List of Research Outputs

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.


Researcher : Mok TMY
Project Title:The role of matrix metalloproteinases and tissue inhibitor of metalloproteinases in neuropsychiatric lupus
Investigator(s):Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2011


List of Research Outputs

Chan V.S.F., Nie Y.J., Shen N., Yan S., Mok T.M.Y. and Lau W.C.S., Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus, Autoimmunity Reviews. 2012, Epub ahead of print.
Chu C.H., Yeung C.M.K., Lai I.A., Leung W.K. and Mok T.M.Y., Oral health of Chinese people with Systemic Sclerosis, Clinical Oral Investigations. 2011, 15(6): 931-939.
Chung H.Y., Lau W.C.S., Wu K.P., Wong R.W.S. and Mok T.M.Y., Comparison of performance of the Assessment of Spondyloarthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis., Clinical Rheumatology . 2011, 30(7): 947-953.
Leung W.K., Chu C.H., Mok T.M.Y., Yeung S.K.W. and Ngai K.S., Periodontal status of adults with system sclerosis: Case-control study, Journal of Periodontology. 2011, 82 (8): 1140-1145.
Li R., Yang W., Zhang J., Hirankarn N., Pan H.F., Mok C.C., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Lee T.L., Ho M.H.K., Lee P.P.W., Chan T.M., Wong W.H.S., Wong C.M., Ng I.O.L., Yang J., Li P.H., Zhang Y., Zhang L., Li W., Baum L., Kwan P., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S., Shen N., Lau Y.L. and Ye D.Q., Association of CD247 with systemic lupus erythematosus in Asian populations, Lupus. 2012, 21(1): 75-83.
Yiu K.H., Tse H.F., Mok T.M.Y. and Lau W.C.S., Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. , Nat Rev Rheumatol.. 2011, 7: 609-18.
Yiu K.H., Mok T.M.Y., Wang S., Ooi C.G.C., Khong P.L., Lau C.S. and Tse H.F., Prognostic role of coronary calcification in patients with rheumatoid arthritis and systemic lupus erythematosus, Clinical and Experimental Rheumatology . 2012, 30: 345-350.


Researcher : Ng FSK
List of Research Outputs

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.


Researcher : Ng KF
List of Research Outputs

Yung S.S.Y., Ng K.F., Yim A.S.Y., Ma M., Lui S.L. and Chan D.T.M., Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate, Journal of the American Society of Nephrology. 2011.


Researcher : Ng KM
Project Title:Role of APOA1 in the cardiac differentiation of pluripotent stem cells
Investigator(s):Ng KM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:09/2010
Completion Date:02/2012


List of Research Outputs

Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Li W., Wang X., Fan W., Zhao P., Chan Y.C., Chen S., Zhang S., Guo X., Zhang Y., Li Y., Cai J., Qin D., Li X., Yang J., Peng T., Zychlinski D., Hoffmann D., Zhang R., Deng K., Ng K.M., Menten B., Zhong M., Wu J., LI Z., Chen Y., Schambach A., Tse H.F., Pei D. and Esteban M.A., Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes., Hum Mol Genet. 2012, 21(1): 32-45.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Ng K.M. and Tse H.F., Modeling Hereditary Cardiac Disease with Patient Specific Induced Pluripotent Stem Cells: Opportunities and Concerns, Journal of cardiovascular pharmacology. 2012.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Ng YCC
List of Research Outputs

Yung S.S.Y., Ng Y.C.C. and Chan D.T.M., Binding of anti-dsDNA antibodies to human proximal tubular epithelial cells induces IL-6 and MCP-1 secretion through MAPK phosphorylation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.


Researcher : Ong KL
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene , Eur J Endocrinol. 2011, 165(4): 571-7.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese, American Journal of Hypertension 2011. 2011, 24 (12): 1331-1337.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure, Clinical and Experimental Hypertension 2011. 2011, 33 (7): 484-491.


Researcher : Pang R.W.C.
Project Title:A study of the modulatory effects of p53 on Pin1-mediated tumor growth, invasion and metastasis in hepatocellular carcinoma
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2008
Completion Date:11/2011


Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang RTW
List of Research Outputs

Wong Y.H.I., Poon M.W., Pang R.T.W., Lian Q. and Wong D.S.H., Promises of stem cell therapy for retinal degenerative diseases , Graefes Arch Clin Exp Ophthalmol. 2011, 249(10): 1439-48.


Researcher : Pang RWC
Project Title:A study of the modulatory effects of p53 on Pin1-mediated tumor growth, invasion and metastasis in hepatocellular carcinoma
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2008
Completion Date:11/2011


Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang SYY
List of Research Outputs

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Lee J.C.Y., Pang S.Y.Y., Lau G.K.K., Teo K.C., Ho S.L., Cheung R.T.F., Kwan S.C. and Chan K.H., Brainstem encephalitis in neuromyelitis optica spectrum disorders, 17th Medical Research conference, Department of Medicine, The University of Hong Kong. Hong Kong Medical Journal. 2012, 18 (Suppl 1): 32.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.
Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.


Researcher : Qiao L
List of Research Outputs

Li Z., Chen J., Chan K.W., Qiao L. and Wong B.C.Y., A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Cancer Lett. 2011, 313(2): 192-200.


Researcher : Ramsden DB
List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Stay Energetic until the End, 7th International Symposium on Healthy Aging: Live Well Age Well, organized by the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong.. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.
Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.
Sung E., Turan N., Ho W.L., Ho S.L., Jarratt P.D.B., Waring R.H. and Ramsden D.B., Detection of endocrine disruptors - from simple assays to whole genome scanning., International Journal of Andrology . 2012.


Researcher : Samaranayake NR
List of Research Outputs

Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 36.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Anti-obesity drugs-are they underused in the United States?, Journal of the Hong Kong College of Cardiology. Presented at the Fifteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong 2011. 19 (2): 69.
Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007-2008, Annals of Epidemiology. 2012, 22 (5): 349-53.
Samaranayake N.R., Chui W.C.M. and Cheung B.M.Y., Medication incidents related to technology in a university-affiliated general hospital in 2006-2010, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 45.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Presented at the International Medication Safety Conference, Hong Kong 2011.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Technology-related medication errors - incidence, nature and causes in a tertiary hospital, Presented at the Hospital Authority Convention 2012, Hong Kong, May 2012.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The Relationship between Waist Circumference and Glycated Hemoglobin in the United States, Journal of the Hong Kong College of Cardiology. Presented at the Twentieth Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong, May 2012. 20 (Suppl 1): A1.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between A1C and waist circumference in the US population, XVI International Symposium on Atherosclerosis 2012, Sydney. 2012.
Samaranayake N.R., Li C., Ong K.L. and Cheung B.M.Y., The association between glycated haemoglobin and waist circumference in the US population, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 43.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of non-intercepted medication errors in a university affiliated teaching hospital, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.
Samaranayake N.R., Cheung S.T.D., Chui C.M.W. and Cheung B.M.Y., The pattern of non-intercepted medication errors in a university affiliated teaching hospital, Presented at the International Medication Safety Conference, Hong Kong 2011.


Researcher : Seto WKW
List of Research Outputs

Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Epub 2011 Sep 29. Review., J Antimicrob Chemother . 2011, 66(12): 2715-25.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B , Hepatology International . 2011, 5(4): 868-875.
Kurosaki M., Yuen R.M.F., Seto W.K.W., Kumada T., Tanaka K., Suzuki Y., Hoshioka Y., Tarnaki N., Kato T., Yasui Y., Hosokawa T., Ueda K., Tsuchiya K., Kuzuya T., Nakanishi H., Itakura J., Takahashi Y., Asahina Y. and Izumi N., Generation of the prediction models for the development of hepatocellular carcinoma in chronic hepatitis B and external validation by independent cohorts, J Hepatol. 2011, 54(Suppl 1): S150-1.
Lam Y.F., Yuen R.M.F., Seto W.K.W. and Lai C.L., Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety., Current Hepatitis Reports. 2011, 10(4): 235-243.
Seto W.K.W., Lai C.L., Hung I.F.N. and Yuen R.M.F., A Large Population Histology Study Showing The Lack Of Association Between Alt Elevation And Significant Fibrosis In Chronic Hepatitis B., PLoS One. 2012, 7(2):e32622.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Acute-on-chronic liver failure in chronic hepatitis B., Journal of Gastroenterology and Hepatology. 2012, 27(4): 662-9.
Seto W.K.W., Best Abstract in Clinical Medicine, Medical Research Conference 2012, Department of Medicine, The University of Hong Kong. 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Hong Kong Association for the Study of Liver Diseases Annual Scientific Meeting, Hong Kong Association for the Study of Liver Diseases. 2011.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Nucleic acid testing for the detection of HBV DNA., Hepatitis Monthly. 2011, 11(10): 847-8.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Presidential Poster of Distinction, The American Association for the Study of Liver Diseases. 2011.
Seto W.K.W., Seminar of Viral Hepatitis for Nurses and Allied Health Professionals, Center of Health Protection, Department of Health. 2012.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Seto WKW
List of Research Outputs

Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Epub 2011 Sep 29. Review., J Antimicrob Chemother . 2011, 66(12): 2715-25.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B , Hepatology International . 2011, 5(4): 868-875.
Kurosaki M., Yuen R.M.F., Seto W.K.W., Kumada T., Tanaka K., Suzuki Y., Hoshioka Y., Tarnaki N., Kato T., Yasui Y., Hosokawa T., Ueda K., Tsuchiya K., Kuzuya T., Nakanishi H., Itakura J., Takahashi Y., Asahina Y. and Izumi N., Generation of the prediction models for the development of hepatocellular carcinoma in chronic hepatitis B and external validation by independent cohorts, J Hepatol. 2011, 54(Suppl 1): S150-1.
Lam Y.F., Yuen R.M.F., Seto W.K.W. and Lai C.L., Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety., Current Hepatitis Reports. 2011, 10(4): 235-243.
Seto W.K.W., Lai C.L., Hung I.F.N. and Yuen R.M.F., A Large Population Histology Study Showing The Lack Of Association Between Alt Elevation And Significant Fibrosis In Chronic Hepatitis B., PLoS One. 2012, 7(2):e32622.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Acute-on-chronic liver failure in chronic hepatitis B., Journal of Gastroenterology and Hepatology. 2012, 27(4): 662-9.
Seto W.K.W., Best Abstract in Clinical Medicine, Medical Research Conference 2012, Department of Medicine, The University of Hong Kong. 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Hong Kong Association for the Study of Liver Diseases Annual Scientific Meeting, Hong Kong Association for the Study of Liver Diseases. 2011.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Nucleic acid testing for the detection of HBV DNA., Hepatitis Monthly. 2011, 11(10): 847-8.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Presidential Poster of Distinction, The American Association for the Study of Liver Diseases. 2011.
Seto W.K.W., Seminar of Viral Hepatitis for Nurses and Allied Health Professionals, Center of Health Protection, Department of Health. 2012.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Shen J
Project Title:Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):Shen J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2003


Project Title:Interactions of Reactive Nitrogen Species, Caveolins and Matrix Metalloproteinases: A Novel Signal Mechanism in Disruption of Blood Brain Barrier during Ischemic Stroke
Investigator(s):Shen J, Chung SK, So KF, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008
Completion Date:08/2011


Project Title:Elucidating caveolin-1 as a negative modulating protein for proliferation of neural stem/progenitor cells and neural differentiation in post-ischemic brain
Investigator(s):Shen J, Chung SK, So KF
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2010


Project Title:Effects of reactive nitrogen species inhibitors on preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in cerebral ischemia-reperfusion injury
Investigator(s):Shen J, Yang D, Liu KJ
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011
Completion Date:03/2012


Project Title:Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cererbal ischemia-reperfersion models
Investigator(s):Shen J, Cheung RTF, Chung SK, Siu DCW, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions
Investigator(s):Shen J, Yang D, So KF
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Using Ski as a molecular target for seeking active compounds from Qingyihuaji (QYHJ) formula for inhibiting pancreatic cancer stem cells
Investigator(s):Shen J, Chen J
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:06/2012




Researcher : Shiu SWM
List of Research Outputs

Shiu S.W.M. and Tan K.C.B., Upregulation of lectin-like oxidized LDL receptor by advanced glycation end products in endothelial cells. , XVI International Symposium on Atherosclerosis, Mar 2012, Sydney.. 2012.
Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products (AGEs) are associated with insulin resistance, Diabetes Metab Res Rev. 2011, 27(5): 488-92.


Researcher : Sim PYJ
List of Research Outputs

Tse E.W.C., Leung A.Y.H., Sim P.Y.J., Lee H.K., Liu H.S., Yip S.F. and Kwong Y.L., Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia., ANNALS OF HEMATOLOGY. 2011, 90(11): 1277-81.


Researcher : Singh GH
List of Research Outputs

Singh G.H., Ip A.H., So J.C.C., Cheng V.C.C., Wong C.S., Yuen K.Y. and Kwong Y.L., Disseminated cryptococcosis mimicking a lymphoma, Eur J Haematol. 2012, 88(3): 275-6.


Researcher : Siu DCW
Project Title:Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:Long-term Efficacy and Safety of a Gene-based Bio-artificial Pacemaker tested in a large animal Sick Sinus Syndrome Model
Investigator(s):Siu DCW, Lau CP, Li RA, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Driven Maturation of Embryonic Stem Cell-Derived Cardiomyocytes via Cardiac Hypertrophic Signals
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010


Project Title:Supraventricular ectopic activity for prediction of atrial fibrillation and ischemic stroke
Investigator(s):Siu DCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:09/2010
Completion Date:08/2011


List of Research Outputs

Chan H.T., So L.T., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation. , J Cardiovasc Pharmacol 2011. 2011, 58: 87-90.
Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chan Y.H., Siu D.C.W., Yiu Y.F., Yiu K.H., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR Prolongation is Associated with Endothelial Dysfunction and Vascular Repair Activation in High Risk Cardiovascular Patients, American Heart Association Scientific Session, Orlando. 2011.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
Jim M.H., Ho H.H., Yiu K.H. and Siu D.C.W., Angiographic and long-term clinical outcome of the sleeve technique in treating in-stent restenotic bifurcation lesions: a preliminary experience., Acute Card Care. 2011, 13(3): 159-63.
Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Lau G.K.K., Yue W.S., Yiu K.H., Siu D.C.W., Wang M.M., Yan G.H. and Tse H.F., Best Abstract in Basic Science & Translational: Impact of Glycaemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2012.
Lau G.K.K., Wong Y.K., Yiu K.H., Siu D.C.W. and Tse H.F., Prognostic implications of non-invasive vascular markers in patients with type 2 diabetes - a 5 year prospective study , Seventh International Symposium on Healthy Aging. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Lee Y.K. and Siu D.C.W., Calcium Handling in hiPSC-derived Cardiomyocytes., SpringerBrief. 2012.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., Li S.W., Fong B., Wong W.K., Tam S. and Tse H.F., Lower habitual physical activity was associated with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease., Cir J 2012. 2012.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Pong V., Chan K.H., Chong B.H., Lui W.M., Leung G.K.K., Tse H.F., Pu J.K.S. and Siu D.C.W., Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage. , Cerebellum. 2012.
Siu D.C.W., 2011 HKU Press Conference HKU’s Breakthroughs in Stem Cell Research New Hopes for Treating Human Diseases , 2011.
Siu D.C.W., 2012 HKU Press Conference HKU Study Provides Insight for Treatment Dilemma in Aspirin Use after a Primary Intracranial Haemorrhage in Chinese , 2012.
Siu D.C.W., 2012 Invited Speaker, Heart Rhythm, 2012, USA, ACC Session, “Integrating HF Diagnostics in Clinical Practice , 2012.
Siu D.C.W., A new approach to anticoagulation to prevent thromboembolic events, The Institute of Cardiovascular Science and Medicine, the University of Hong Kong, Fifteenth Annual Scientific Meeting. 2011.
Siu D.C.W., Tse H.F. and Lau C.P., A shock in time saves ablation?, Europace. 2011, 13: 155-6.
Siu D.C.W. and Tse H.F., Cardiac regeneration: messages from CADUCEUS, . Lancet. 2012, 379: 870-1.
Siu D.C.W., Editorial Board , Open journal of regenerative medicine, 2012.
Siu D.C.W., Editorial Board , World Journal of Critical Care Medicine, 2012.
Siu D.C.W., Wong M.P., Ho J.C.M., Lam C.L.D. and Tse H.F., Fatal lung toxicity related to Dronedarone use., Arch Int Med . 2012, 172 (6): 516 - 517.
Siu D.C.W., HKU’s Breakthroughs in Stem Cell Research New Hopes for Treating 2012 HKU Press Conference HKU Study Provides Insight for Treatment Dilemma in Aspirin Use after a Primary Intracranial Haemorrhage in Chinese , 2012.
Siu D.C.W., International Advisory Board , Journal of Arrhythmias. 2012.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.
Siu D.C.W., Optimization Before Hip Fracture Surgery, 8th HK International Orthopaedic Forum. 2011.
Siu D.C.W., Prophylaxis for Thromboembolism in Atrial Fibrillation: For Whom and How?, The Annual Scientific Meeting, Hong Kong Public Hospital Cardiologists Association (HKPHCA). 2011.
Siu D.C.W., Safety and Efficacy of Warfarin Therapy in Chinese, Asian Pacific Heart Rhythm Society Annual Scientific Meeting (2011, Fukuoka, Japan). 2011.
Siu D.C.W., The 14th South China International Congress of Cardiology, China “ Spinal Cord stimulation for treatment of cardiac arrhythmias”, 2012.
Siu D.C.W. and Tse H.F., Thromboembolic risk of the hot- and cold- catheter ablation for atrial fibrillation. , Heart Rhythm 2011 . 2011.
Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Thromboprophylaxis in patients with acute atrial fibrillation. , Acute Cardiac Care. . 2011.
Stolen C.M., Siu D.C.W., Lam Y.M. and Tse H.F., Pacing to reduce angina in patients with severe coronary artery disease. , J Cardiovasc Transl Res. . 2012, 5: 84-91.
Wang M., Yan G.H., Yue W.S., Siu D.C.W., Lee S.W.L., Lau C.P. and Tse H.F., Effects of low right atrial septal versus right atrial appendage pacing on atrial mechanical function in patients with sinus node dysfunction and atrial fibrillation. , Europace. 2012.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.
Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients after elective percutaneous coronary intervention. , Cardiovasc Diabetol.. 2011, 10: 52.
Yiu K.H., Yeung C.K., Zhao C.T., Chan J.C., Siu D.C.W., Tam S., Wong C.S., Yan G.H., Yue W.S., Khong P.L., Cha H. and Tse H.F., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis., J Intern Med. 2012.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M., Yan G.H., Yiu K.H. and Tse H.F., Impact of Glycemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus , Cardiovascular Diabetology. 2011, 10(1):113.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M.M., Yan G.H., Yiu K.H. and Tse H.F., Impact of glycaemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18: 63.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : So HF
List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.


Researcher : So HF
List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.
Liu H., Ho W.L., Ho W.M., So H.F., Ramsden D.B. and Ho S.L., Generation and phenotypic analysis of LRRK2 R1441G knockin mouse model for study of Parkinson’s Disease, In: The XIX World Congress on Parkinson’s Disease and Related Disorders, 2011.


Researcher : Soong SS
List of Research Outputs

Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.


Researcher : Sun H
List of Research Outputs

Che H., Sun H. and Li G.R., Functional transient receptor potential channels in human cardiac c-kit cells, Hong Kong - Taiwan Physiology Symposium, June. 2012, 51.
Chen J., Liu W., Che H., Liu J., Sun H. and Li G.R., Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. , Br J Pharmacol. . 2012, 166(3): 1140-1150.
He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H., Wu W., Sun H. and Li G.R., The natural flavone acacetin blocks kv4.3 current by interacting with P-loop filter helix of the channel, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Tam HL
List of Research Outputs

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products (AGEs) are associated with insulin resistance, Diabetes Metab Res Rev. 2011, 27(5): 488-92.


Researcher : Tam KY
List of Research Outputs

Tang S.C.W., Lin M., Tam K.Y., Au W.S., Ma M.K., Ho W.Y. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrol. Dial. Transplant.. 2012, 27: 613-8.


Researcher : Tam S
List of Research Outputs

Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012.
Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.


Researcher : Tan KCB
Project Title:MircoRNA and reverse cholesterol transport
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2009
Completion Date:11/2011


Project Title:Reverse cholesterol transport and diabetic nephropathy
Investigator(s):Tan KCB, Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Carbamylated LDL and diabetes
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2011


List of Research Outputs

Cheung C.L., Nguyen U.S., Au E., Tan K.C.B. and Kung A.W.C., Association of handgrip strength with chronic diseases and multimorbidity: A cross-sectional study., Age. 2012.
Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Cheung E.Y.N., Cheung C.L., Sahni S., Kung A.W.C. and Tan K.C.B., The positive association of lignan and flavonoid intakes with bone mineral density in men from Southern China. , European Congress on Osteoporosis and Osteoarthritis, Mar 2012, Bordeaux, France.. 2012.
Kumana C.R., Cheung B.M.Y. and Tan K.C.B., Impact on absolute mortality due to intensive glucose lowering for patients with diabetes, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 29.
Lam C.M.J., Tan K.C.B., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea., Sleep Medicine. 2012, 13(1): 15-20.
Lui M.M.S., Tse H.F., Mak J.C.W., Lam J.C.M., Lam C.L.D., Tan K.C.B. and Ip M.S.M., Altered endothelial repair capacity in obstructive sleep apnea in relation to elevated advanced glycation endproducts., Asia Pacific Society of Respirology Annual Congress, Nov 2011, Shanghai.. 2011.
Shiu S.W.M. and Tan K.C.B., Upregulation of lectin-like oxidized LDL receptor by advanced glycation end products in endothelial cells. , XVI International Symposium on Atherosclerosis, Mar 2012, Sydney.. 2012.
Tan K.C.B., Beijing Baishideng BioMed Scientific Co. Ltd., World Journal of Diabetes. 2011.
Tan K.C.B., Bentham Science Publishers, The Open Diabetes Journal. 2011.
Tan K.C.B., Bentham Science Publishers, The Open Translational Medicine Journal. 2011.
Tan K.C.B., Chairman of the Organising Committee of the 17th Hong Kong Medical Forum., Organising Committee of the 17th Hong Kong Medical Forum.. 2012.
Tan K.C.B., Current medical practice for diabetes in Hong Kong., Diabetes Strategy.. 2011, 36-62.
Tan K.C.B., Diabetic dyslipidaemia., Hong Kong-Beijing-Harbin Medical Forum, Apr 2012, Harbin.. 2012.
Tan K.C.B., Editor, Elsevier., Obesity Research & Clinical Practice.. 2012.
Tan K.C.B., Enhancing early and optimal glycemic control – what can DPP-4 inhibition offer?, Symposium on Treating Patients with Hypertension, Diabetes and Nephropathy, Sept 2011, Macau.. 2011.
Tan K.C.B., Experience with incretin-based therapy., Hong Kong College of Physicians Annual Scientific Meeting, Oct 2011, Hong Kong.. 2011.
Tan K.C.B., Honorary Editorial Advisory Board Member, MIMS Endocrinology Guide. 2012.
Tan K.C.B., How to achieve better control of diabetes?, HK Primary Care Conference, June 2012, Hong Kong.. 2012.
Tan K.C.B., Journal of Diabetes Investigation, 2011.
Tan K.C.B., Member of the Grant Review Board of the Research Council of the Food and Health Bureau 2012 - 2013., Grant Review Board of the Research Council of the Food and Health Bureau 2012 - 2013.. 2012.
Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products (AGEs) are associated with insulin resistance, Diabetes Metab Res Rev. 2011, 27(5): 488-92.
Tan K.C.B., Wiley-Blackwell., Clinical obesity.. 2012, 2012-2013.
Wan S.F., Chan S.S.C., Tan K.C.B. and Lam T.H., The association between smoking and HbA1c level among type II diabetic patients: A systematic review, The 5th Cross-Strait Conference on Tobacco Control, Taipei, Taiwan, 4-5 September. 2011, 195.
Wan S.F., Lam T.H., Tan K.C.B. and Chan S.S.C., Understanding the Association of Active and Passive Smoking with HbA1c level and the Number of Diabetes-related Complications in Type II Diabetic Patients: A Cross-sectional Study, 16th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, December 7 & 8, 2011. Hong Kong.


Researcher : Tan V.P.Y.
Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


List of Research Outputs



Researcher : Tan VPY
Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


List of Research Outputs

Ma T.K., Lam Y.Y., Tan V.P.Y. and Yan B.P., Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions?, In: J.C. (Ian) McGrath, British Journal of Clinical Pharmacology. Wiley InterScience, 2011, 72(4): 697-706.
Tan V.P.Y., Wong R.W.M., Hung I.F.N. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., J Gastroenterol. 2011, 46(7):906-12.
Tan V.P.Y., Wong W.M., Cheung T.K., Lai K.C., Chan P., Pang R.W.C. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., In: T. Azuma, Journal of Gastroenterology. Wiley InterScience, 2011, 46(7): 906-12.


Researcher : Tang CW
Project Title:Role of N-acetyl-seryl-aspartyl-lysyl-proline in nephropathies
Investigator(s):Tang SCW, Lan HY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Forefronts 2011 Ac-SDKP attenuates proinflammation in protein-overloaded renal tubular cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011
Completion Date:09/2011


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Potential therapeutic role of bone marrow-derived mesenchymal stromal/stem cells in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs



Researcher : Tang L
List of Research Outputs

Tang L., Pu Y., Wong D.K.H., Liu T., Tang H., Xiang T.X., Yuen R.M.F. and Ren G.S., The hepatitis B virus-associated estrogen receptor alpha (ER alpha) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells , Acta Biochimica Et Biophysica Sinica . 2011, 43 (Issue: 8): 640-646.


Researcher : Tang SCW
Project Title:Role of N-acetyl-seryl-aspartyl-lysyl-proline in nephropathies
Investigator(s):Tang SCW, Lan HY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009


Project Title:Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Forefronts 2011 Ac-SDKP attenuates proinflammation in protein-overloaded renal tubular cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011
Completion Date:09/2011


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Potential therapeutic role of bone marrow-derived mesenchymal stromal/stem cells in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.
Chan G.C., Leung A.Y.H., Wong A.S., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft patients, Renal Failure . 2012, 34: 550-554.
Lai K.N., Lam M.F., Leung J.C.K., Chan Y.Y., Lam C.W., Chan I.H., Chan H.W., Li C.S., Wong S.S., Ho Y.W., CHEUK A., Tang M.K. and Tang S.C.W., A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products, Peritoneal Dialysis International. 2011, 32(3): 280-91.
Lai K.N., Tang S.C.W. and Leung J.C.K., Recent advances in IgA nephropathy - the glomerulopodocytic-tubular communication, Advances in Otorhinolaryngology. 2011, 72: 40-4.
Lai K.N., Leung J.C.K. and Tang S.C.W., Recent advances in IgA nephropathy – the glomerulo-podocytic-tubular communication, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 72: 40-44.
Lam C.L.K., Chan G.C.F., Lam T.H., Lee P.P.W., Leung A.Y.M., Leung G.K.K., Tang S.C.W. and Tsao G.S.W., 育醫造才: 探索醫學世界 第二冊, 香港大學李嘉城醫學院, 2012, 第二冊.
Leung J.C.K., Chan Y.Y., Tang S.C.W., Lam M.F., Chow C.W., Lim A.I. and Lai K.N., Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone, Journal of Translational Medicine. 2011, 9: 169-183.
Leung J.C.K., Chan Y.Y., Lam M.F., Tang S.C.W., Chow C.W., Lim A.I. and Lai K.N., The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid, Nephrology Dialysis Transplantation ePub. 2012.
Lim A.I., Chan Y.Y., Lai K.N., Tang S.C.W., Chow C.W., Lam M.F. and Leung J.C.K., Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells, International Journal of Biochemistry and Cell Biology . 2012, 44: 1040-1050.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Liu J., Cai Y.Z., Wong R.N., Lee C.K., Tang S.C.W., Sze S.C., Tong Y. and Zhang Y., Comparative analysis of caffeoylquinic acids and lignans in roots and seeds among various burdock (Arctium lappa) genotypes with high antioxidant activity, Journal of Agricultural and Food Chemistry . 2012, 60: 4067-4075.
Ma M.K., Yap Y.H.D. and Tang S.C.W., Transplant kidney herniation in an elderly patient., Nephrology (Carlton). 2011, 16: 511-7.
Song J.X., Shaw P.C., Wong N.S., Sze C.W., Yao X.S., Tang S.C.W., Tong Y. and Zhang Y.B., Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP(+), but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells, Neuroscience Letters. 2011, 11: 521:76-81.
Tang S.C.W., Lin M., Tam K.Y., Au W.S., Ma M.K., Ho W.Y. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrol. Dial. Transplant.. 2012, 27: 613-8.
Tang S.C.W., Editorial Board, World Journal of Journal Urology. Baishideng Publishing Group, 2011.
Tang S.C.W., Exploring the role of the direct renin inhibitor in nephropathy, Novartis Cardiovascular and metabolic symposium (Macau). 2011.
Tang S.C.W., Hepatitis B and C in renal disease: an update, Oriental Nephrology Forum (Shanghai, China). 2011.
Tang S.C.W., Herbs do not cause CKD, 6th Meeting of the Asian Forum of Chronic Kidney Disease Initiative of the Asian Pacific Society of Nephrology (APSN) and Annual Conference of the North Zone Chapter of Indian Society of Nephrology (Chandigarh, India). 2012.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents Against IgA Nephropathy, In: Y. Harabuchi, T. Hayashi and A. Katada, Advances in Oto-Rhino-Laryngology: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Basel, Switzerland, S Karger AG, 2011, 45-49.
Tang S.C.W., Leung J.C.K. and Lai K.N., Immunomodulatory Agents against IgA Nephropathy, Advances in Otorhinolaryngol. 2011, 72: 45-9.
Tang S.C.W., Management of dyslipidemia in patients with chronic kidney disease, 13th Hong Kong Diabetes and Cardiovascular Risk Factors - East Meets West Symposium (Hong Kong, China). 2011.
Tang S.C.W., The Oxford Classification of IgA Nephropathy, Asian Immunology and Transplant Forum (Huangshan, China). 2011.
Tang S.C.W. and Lai K.N., The pathogenic role of the renal proximal tubular cell in diabetic nephropathy, Nephrology Dialysis Transplantation. 2012, ePub.
Tang S.C.W., Yu Professorship in Nephrology, The University of Hong Kong. 2012.
Wong M.Y., Lau S.K.P., Tang S.C.W., Curreem S.O.T., Woo P.C.Y. and Yuen K.Y., First Report of Peritoneal Dialysis-Related Peritonitis Caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.
Wong M.Y., Lau S.K., Tang S.C.W., Curreem S.O., Woo P.C. and Yuen K.Y., First report of peritoneal dialysis-related peritonitis caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Yap Y.H.D., Hwang Y.Y., Lam J.K. and Tang S.C.W., Gas in the renal shadow of a plain abdominal X-ray: emphysematous pyelonephritis, Nephrology (Carlton). 2012, 16: 119-20.
Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.
Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.
Zhang Y., Tong Y., Sze C.W., Tang S.C.W., Ho J.C.M., Ng T.B. and Liao Q.X., Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation. , In: Zhang YB*, Tong Yao, Sze CW, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region. (Project code: ITS/313/11).. 2012.
Zhang Y., Sze C.W., Tong Y., Tang S.C.W., Ho J.C.M., Ng T.B. and Liao X.Q., PI: HK$223,300.00 (April 27, 2012). Zhang YB*, Stephen Sze CW, Tong Y, Ng TB, Liao XQ, Ho CM, Tang CW. Investigation of Therapeutic Efficacy and Mechanisms of Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced Pulmonary Inflammation. , In: Zhang YB*, Stephen Sze CW, Tong Y, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Fund Internship Programme of Hong Kong (Project code: InP/066/12).. 2012.
Zhang Y., Sze C.W., Tong Y., Ng T., Liao X., Tang S.C.W. and Ho J.C.M., PI: HK$826,701.00 (March 23, 2012). Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation. , In: Zhang YB*, Tong Yao, Sze CW, Ng TB, Liao XQ, Ho CM, Tang CW., Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region (Project code: ITS/313/11).. 2012.


Researcher : Tang SOC
List of Research Outputs

Chong Y.B., Yap Y.H.D., Tang S.O.C. and Chan D.T.M., Dyslipidemia in patients with lupus nephritis., Nephrology (Carlton). 2011, 16: 511-7.


Researcher : Tong SM
List of Research Outputs

Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.


Researcher : Tse CTA
List of Research Outputs

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.
Lau G.K.K., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee C.Y., Ho S.L. and Chan K.H., Viral Encephalitis in Hong Kong - A Hospital-Based Study, 64th American Academy of Neurology Annual Meeting. 2012.
Leung G.K.K., Pang K.K.W., Tsang K.L., Tse C.T.A., Pang S.Y.Y., Cheung R.T.F., Ho S.L., Lau G.K.K., Teo K.C. and Chan K.H., Cryptococcal meningitis: a hospital-based study, Seventeenth Medical Research Conference. 2012, 47.


Researcher : Tse EWC
Project Title:Identification and characterization of Pin1 binding proteins
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2010
Completion Date:12/2011


Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:Pin1 modulates the functions of HIF-1 alpha in cancer cells
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2011


Project Title:Thirteen International Symposium of Society of Chinese Bioscientists in America (Bioscience for the 21st Century: Emerging Frontiers and Evolving Concepts) The significance of Pin1 over-expression in hepatocellular carcinoma
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2011
Completion Date:07/2011


Project Title:Enhancing the anti-leukaemia effect of arsenic tiroxide by dexamethasone
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Au W.Y., Leung A.Y.H., Tse E.W.C., Chim J.C.S., Loong F. and Kwong Y.L., Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment, Clin Transplant. 2012.
Chim J.C.S., Lie A.K.W., Chan Y.E.T., Liu H.S.Y., Lau C.W., Yip S.Y., Sim J., Wan T.S.K., Ma E.S.K., Liang R.H.S., Tse E.W.C. and Kwong Y.L., Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD, Journal of Hematology and Oncology. 2012, 8;5(1): 28.
Hwang Y.Y., Leung A.Y.H., Lau W.H., Loong F., So J.C.C., Tse E.W.C. and Kwong Y.L., Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma, Histopathology. 2011, 59(2): 352-5.
Tse E.W.C., Leung A.Y.H., Sim P.Y.J., Lee H.K., Liu H.S., Yip S.F. and Kwong Y.L., Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia., ANNALS OF HEMATOLOGY. 2011, 90(11): 1277-81.
Tse E.W.C. and Kwong Y.L., Treatment algorithms for mature T-cell and natural killer-cell neoplasms, Future Oncology. 2011, 7(9): 1101-12.


Researcher : Tse HF
Project Title:Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):Tse HF, Lau CP, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004


Project Title:Outstanding Researcher Award 2007-2008
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:10/2008


Project Title:Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan FHW, Lam L, Lee KLF, Chan WS, Lam YM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases
Investigator(s):Tse HF, Li RA, Siu DCW, Li GR, Lian Q
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:03/2010


Project Title:Autologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy
Investigator(s):Tse HF, Li RA, Siu DCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Attenuation of Left Ventricular Remodeling and Improvement of Myocardial Function with Spinal Cord Stimulation in Post-myocardial Infarction Heart Failure
Investigator(s):Tse HF, Siu DCW, Wang MM, Yiu KH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2011


Project Title:Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2012


List of Research Outputs

Ambegaonkar B., Chirovsky D., Tse H.F., Lau Y.K., Tomlinson B., Li S.K., Yue C.S., Wong T.H., Choi M.C., Tunggal P. and Sazonov V., Attainment of Normal Lipid Levels Among Patients on Lipid-Modifying Therapy in Hong Kong. , Adv Ther. . 2012.
Amerena J., Chen S.A., Sriratanasathavorn C., Cho J.G., Dejia H., Omar R., Tse H.F. and King A., Insights into the management of atrial fibrillation in Asoa Pacific: baseline data from the RecordAF-AP Registy, . Am J Cardiol. . 2011.
Chan H.T., So L.T., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation. , J Cardiovasc Pharmacol 2011. 2011, 58: 87-90.
Chan H.T., Yiu K.H., Li S.W., Wong C.Y., Lam S. and Tse H.F., Increased dietary fruit intakes was associated with lower burden of carotid atherosclerosis in patients with Type 2 diabetes mellitus. , Diabetic Med. 2012.
Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chan Y.H., Li S.W., Lam T.H., Lau C.P. and Tse H.F., Best Original Research by Trainees Silver Medal 2011 (Abstract titled: PR Interval Prolongation is Associated with Endothelial Dysfunction, Arterial stiffness and Activation of Vascular Repair: Novel Pathophysiological Insights and Clinical Implications), Hong Kong Academy of Medicine. Hong Kong, Hong Kong Academy of Medicine, 2011.
Chan Y.H., Siu D.C.W., Yiu Y.F., Yiu K.H., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR Prolongation is Associated with Endothelial Dysfunction and Vascular Repair Activation in High Risk Cardiovascular Patients, American Heart Association Scientific Session, Orlando. 2011.
Chan Y.H., Siu C.W., Yiu Y.F., Yiu K.H., Li S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is associated with endothelial dysfunction and activation of vascular repair in high risk cardiovascular patients (abstract and oral presentation), Circulation Supplement 1: American Heart Association Scientific Sessions 2011, 12-16 November 2011, Orlando, USA. 2011, 124 (Suppl 1): Abstract 8488.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Chiang C.E., Zhang S., Tse H.F., Teo W.S., Omar R. and Sriratanasathavorn C., Atrial fibrillation management in Asia: From the Asian expert forum on atrial fibrillation, Int J Cardiol. 2012.
Chong B.H., Chan K.H., Pong V., Lau G.K.K., Chan Y.H., Zuo M.L., Lui W.M., Leung G.K., Lau C.P., Tse H.F., Pu J.K. and Siu D.C.W., Use of aspirin in Chinese after recovery from primary intracranial haemorrhage, Thrombosis and Haemostasis. 2011, 107(2).
Connolly S.J., Camm A.J., Halperin J., Hart R., Alings M., Amerena J., Atar D., Avezum A., Blomstrom P., Borgreffe M., Budaj A., Chen S.A., Ching C.K., Commerford P., Dans A., Marc D.A.V.Y. .J., Delacretaz E., Di Pasquale G., Diaz R., Dorian P., Flaker G., Golitsyn S., Gonzalen-Hermosillo A., Granger C., Heidbuchel H., Kautzner J. and Tse H.F., Effects of Dronedarone in Permanent Atrial Fibrillation. , N Engl J Med.. 2011, 365: 2268-76.
He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.
Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Lau G.K.K., Yue W.S., Yiu K.H., Siu D.C.W., Wang M.M., Yan G.H. and Tse H.F., Best Abstract in Basic Science & Translational: Impact of Glycaemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2012.
Lau G.K.K., Wong Y.K., Yiu K.H., Siu D.C.W. and Tse H.F., Prognostic implications of non-invasive vascular markers in patients with type 2 diabetes - a 5 year prospective study , Seventh International Symposium on Healthy Aging. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau V.Y.M., Tse H.F. and Siu D.C.W., Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain. , In: Hayat MA , Stem Cells and Cancer Stem Cells. 2012.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgrad Med . 2011, 123(6): 66-71.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgraduate Medicine. 2011, 123(6): 66-71.
Li W., Wang X., Fan W., Zhao P., Chan Y.C., Chen S., Zhang S., Guo X., Zhang Y., Li Y., Cai J., Qin D., Li X., Yang J., Peng T., Zychlinski D., Hoffmann D., Zhang R., Deng K., Ng K.M., Menten B., Zhong M., Wu J., LI Z., Chen Y., Schambach A., Tse H.F., Pei D. and Esteban M.A., Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes., Hum Mol Genet. 2012, 21(1): 32-45.
Li X., Tse H.F. and Jin L., Novel endothelial biomarkers: Implications for periodontal disease and CVD, Journal of Dental Research. 2011, 90: 1062-1069.
Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Lian Q. and Tse H.F., Human Induced Pluripotent Stem cells for Regenerative Medicine, The 2nd Hk-uk Frontiers Of Science Meeting (organized By The Royal Society, Uk And The Croucher Foundation, Hong Kong . London,5-8. September, 2011.. 2011.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Lip G.Y., Halperin J.L. and Tse H.F., The new 2010 European Society of Cardiology guidelines on atrial fibrillation management- an evolution or revolution? , Chest.. 2011, 13: 514-9.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Liu Y., Lai K.W.H., Liao S., Siu D.C.W. and Tse H.F., Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium, J Cardiovasc Transl Res. 2012, 5(3): 359-64.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Lui M.M.S., Tse H.F., Mak J.C.W., Lam J.C.M., Lam C.L.D., Tan K.C.B. and Ip M.S.M., Altered endothelial repair capacity in obstructive sleep apnea in relation to elevated advanced glycation endproducts., Asia Pacific Society of Respirology Annual Congress, Nov 2011, Shanghai.. 2011.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., Li S.W., Fong B., Wong W.K., Tam S. and Tse H.F., Lower habitual physical activity was associated with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease., Cir J 2012. 2012.
Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37.
Ng K.M. and Tse H.F., Modeling Hereditary Cardiac Disease with Patient Specific Induced Pluripotent Stem Cells: Opportunities and Concerns, Journal of cardiovascular pharmacology. 2012.
Pong V., Chan K.H., Chong B.H., Lui W.M., Leung G.K.K., Tse H.F., Pu J.K.S. and Siu D.C.W., Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage. , Cerebellum. 2012.
Siu D.C.W., Tse H.F. and Lau C.P., A shock in time saves ablation?, Europace. 2011, 13: 155-6.
Siu D.C.W. and Tse H.F., Cardiac regeneration: messages from CADUCEUS, . Lancet. 2012, 379: 870-1.
Siu D.C.W., Wong M.P., Ho J.C.M., Lam C.L.D. and Tse H.F., Fatal lung toxicity related to Dronedarone use., Arch Int Med . 2012, 172 (6): 516 - 517.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.
Siu D.C.W. and Tse H.F., Thromboembolic risk of the hot- and cold- catheter ablation for atrial fibrillation. , Heart Rhythm 2011 . 2011.
Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Thromboprophylaxis in patients with acute atrial fibrillation. , Acute Cardiac Care. . 2011.
Stolen C.M., Siu D.C.W., Lam Y.M. and Tse H.F., Pacing to reduce angina in patients with severe coronary artery disease. , J Cardiovasc Transl Res. . 2012, 5: 84-91.
Tang S., Lecina M., Chan Y.C., Tse H.F., Reuveny S. and Oh S.K.W., Increasing cardiomyogenesis of hESC by enhancing cell survival using an improved serum free media., Stem Cell Research (In Preparation). 2012.
Tse H.F., Invited Speaker, The Vatican, Italy, “ Clinical Focus: Cardvascular Disease”, 2011.
Tse H.F., Invited Speaker,“ South East Asia Stroke Prevention in AF Advisory”, SPAF clinical research updates”,, 2011.
Tse H.F., 1. Invited Speaker, The Fourth Ventricular Arrhythmia Symposium of China (VAS-China), Nanjing, China ,” Prevention of Ventricular tachycardia with spinal cord stimulation”, 2012.
Tse H.F., Invited Speaker, 4th Asia Pacific Heart Rhythm Society Scientific Sessions “ECG algorithm for epicedial VT/VPB”, “Idealized pacing therapy with optimal rate adaptive feature/programming , 2011.
Tse H.F., Invited Speaker, 9th China Atrial Fibrillation, Symposium, Beijing, “ What’s new on AF management guideline?, 2011.
Tse H.F., Invited Speaker, Boston Scientific Ltd during 4th Asia Pacific Heart Rhythm Society v Scientific Sessions meeting, “Idealizzsed pacing therapy with optimal rate adaptive feature/programming, 2011.
Tse H.F., Invited Speaker, The 6th Oriental Congress of Cardiology (OCC 2012), Shanghai, China “ Spinal Cord stimulation for treatment of heart failure”, 2012.
Tse H.F., Invited Speaker, “ Kuala Lumpur Valve Summit 2011” Oral Aticoagulants in Stroke Prevention”, “New Treatment Strategies to Address Unmet Needs in Stroke Prevention in AF” , 2011.
Tse H.F., Public talk – 港大研究調查發現服用薄血藥華法林的心房顫動患者 經常進食可影響藥效的草本食材 須留意謹慎用藥, 2012.
Wang M., Yan G.H., Yue W.S., Siu D.C.W., Lee S.W.L., Lau C.P. and Tse H.F., Effects of low right atrial septal versus right atrial appendage pacing on atrial mechanical function in patients with sinus node dysfunction and atrial fibrillation. , Europace. 2012.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yiu K.H., Schouffoer A.A., Marsan N.A., Ninaber M.K., Stolk J., Vlieland T.V., Scherptong R.W., Delgado V., Homlan E.R., Tse H.F., Huizinga T.W., Bax J.J. and Schuerwegh A.J., Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: Relationship to functional capacity and ventricular arrhythmias. , Arthritis Rheum.. 2011, 63: 3969-78.
Yiu K.H., Tse H.F., Mok T.M.Y. and Lau W.C.S., Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. , Nat Rev Rheumatol.. 2011, 7: 609-18.
Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients after elective percutaneous coronary intervention. , Cardiovasc Diabetol.. 2011, 10: 52.
Yiu K.H., Atsma D.E., Delgado V., Ng A.C., Witkowski T.G., Ewe S.H., Auger D., Holman E.R., van M.I.L. .A.M., Breuning M.H., Tse H.F., Bax J.J., Schalij M.J. and Marsan N.A., Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers., Plos One. 2012, 7: e36115.
Yiu K.H., Yeung C.K., Zhao C.T., Chan J.C., Siu D.C.W., Tam S., Wong C.S., Yan G.H., Yue W.S., Khong P.L., Cha H. and Tse H.F., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis., J Intern Med. 2012.
Yiu K.H., Mok T.M.Y., Wang S., Ooi C.G.C., Khong P.L., Lau C.S. and Tse H.F., Prognostic role of coronary calcification in patients with rheumatoid arthritis and systemic lupus erythematosus, Clinical and Experimental Rheumatology . 2012, 30: 345-350.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M., Yan G.H., Yiu K.H. and Tse H.F., Impact of Glycemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus , Cardiovascular Diabetology. 2011, 10(1):113.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M.M., Yan G.H., Yiu K.H. and Tse H.F., Impact of glycaemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18: 63.
Yung S.Y.J., Tse H.F., Tam P.K.H. and Ngan E.S.W., Establishing a patient-specific iPSC model for Hirschsprung’s disease and other neural crest-associated diseases, The 10th Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan, 13 - 16 June 2012.
Yung S.Y.J., Chow H.M., Tse H.F., Tam P.K.H. and Ngan E.S.W., Generation of patient-specific iPSCs for Hirschsprung's disease modelling, Days of Molecular Medicine 2011, Hong Kong, 10-12 November 2011.
Yung S.Y.J., Tse H.F., Wan T.S.K., Tam P.K.H. and Ngan E.S.W., Modelling Hirschsprung’s disease using patient-specific iPS cells, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25 - 28 March 2012.
Yung S.Y.J., Tse H.F., Tam P.K.H. and Ngan E.S.W., iPS cell-derived neural crest cells from a patient with Hirschsprung's disease show a reduced differentiation plasticity, The 10th Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan, 13 - 16 June 2012.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.


Researcher : Tse HM
List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H., Ramsden D.B. and Ho S.L., Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease, Translational Neurodegeneration . 2012, 1:3.
Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.
Ho W.L., Ho W.M., Tse H.M., So H.F., Chan K.H., Liu H., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases neuronal ATP production via respiratory Complex-II activation – a bioenergetic study. , XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011.. 2011.
Ho W.M., Ho W.L., Liu H., So H.F., Chan K.H., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress., Free Radical Biology and Medicine. 2012.


Researcher : Tse KC
List of Research Outputs

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.


Researcher : Tse WW
List of Research Outputs

Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., 4-methylumbelliferone suppresses hyaluronan synthesis in NZB/W F1 mice and reduces immune-mediated renal inflammation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Suppression of hyaluronan synthesis with 4-methylumbelliferone in NZB/W F1 mice is associated with reduced renal inflammation and renal function improvement, Journal of the American Society of Nephrology. 2011.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of hyaluronan synthesis with 4-methylumbelliferone in NZBWF1/J mice is associated with improved renal function and reduced renal inflammation, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.


Researcher : Tso AWK
Project Title:A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2008


Project Title:Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):Tso AWK, Lam KSL, Chan DTM, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2009


List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene , Eur J Endocrinol. 2011, 165(4): 571-7.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese, American Journal of Hypertension 2011. 2011, 24 (12): 1331-1337.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Chow W.S., Yuen M.A.M., Tso A.W.K., Fong H.Y., Lo S.V., Lam K.S.L. and Cheung B.M.Y., Non-traditional biomarkers in the prediction of cardiovascular events among Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 20.
Lee C.H., Yuen M.M.A., Chow W.S., Tso A.W.K., Yeung C.K., Chan J.C.Y., Chau C.H. and Lam K.S.L., A man with a blistering eruption and tuberculosis, BMJ. 2012, 344: d8351.
Lee P.C.H., Chow W.S., Yuen M.A.M., Tso A.W.K., Xu A., Law S.C., Cheung S.C.W., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin levels are predictive of carotid intima-medial thickness in a 5-year community-based prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 32.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure, Clinical and Experimental Hypertension 2011. 2011, 33 (7): 484-491.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.
Yu H.Y., Woo J., Chan R., Sham A., Ho S., Tso A.W.K., Cheung B.M.Y., Lam T.H. and Lam K.S.L., Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey, Public Health Nutrition 2011 . 2011, 14 (7): 1133-1141.


Researcher : Tsoi TH
List of Research Outputs

Pang S.Y.Y., Chan K.H., Mak W., Kung M.H.W., Lee C.N., Tsoi T.H., Yip K.K. and Ho S.L., Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy, Journal of the Peripheral Nervous System. 2012, 17: 72-75.


Researcher : Wang AYM
Project Title:An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):Wang AYM, Kwan CW, Lai KN
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:07/2008


Project Title:Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):Wang AYM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010




Researcher : Wang J
Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang J.
Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang KLJ
List of Research Outputs

Wang K.L.J., Ho J.C.M., Yee W., Mok T., Chan J., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., Association of inhaled corticosteroids with insulin resistance, adiponectin and high-sensitivity C reactive protein in adults with asthma, American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1777.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T., Tam S., Cheung B.M.Y., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effect of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD study), American Journal of Respiratory and Critical Care Medicine. Presented at the International Conference of the American Thoracic Society, San Francisco 2012. 185: A1776.


Researcher : Wang MM
List of Research Outputs

Lau G.K.K., Yue W.S., Yiu K.H., Siu D.C.W., Wang M.M., Yan G.H. and Tse H.F., Best Abstract in Basic Science & Translational: Impact of Glycaemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2012.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M.M., Yan G.H., Yiu K.H. and Tse H.F., Impact of glycaemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18: 63.


Researcher : Wang Y
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Deng X.L. and Li G.R., Epidermal growth factor stimulates cell proliferation by activating voltage-gated potassium channels in rat bone marrow-derived mesenchymal stem cells, Kong - Taiwan Physiology Symposium, June. 2012, 55.


Researcher : Wang Y
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Deng X.L. and Li G.R., Epidermal growth factor stimulates cell proliferation by activating voltage-gated potassium channels in rat bone marrow-derived mesenchymal stem cells, Kong - Taiwan Physiology Symposium, June. 2012, 55.


Researcher : Wang Y
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Deng X.L. and Li G.R., Epidermal growth factor stimulates cell proliferation by activating voltage-gated potassium channels in rat bone marrow-derived mesenchymal stem cells, Kong - Taiwan Physiology Symposium, June. 2012, 55.


Researcher : Wang Y
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Deng X.L. and Li G.R., Epidermal growth factor stimulates cell proliferation by activating voltage-gated potassium channels in rat bone marrow-derived mesenchymal stem cells, Kong - Taiwan Physiology Symposium, June. 2012, 55.


Researcher : Wat NMS
List of Research Outputs

Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.


Researcher : Wong ASY
List of Research Outputs

Chan C.W., Leung A.Y.H., Wong A.S.Y., Chan K.W., Kwong Y.L., Lai K.N. and Tang S.C.W., Quantification of BK viral load in asymptomatic renal allograft recipients, Ren Fail. 2012, 34(5): 550-4.


Researcher : Wong B.C.Y.
Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs



Researcher : Wong BCY
Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

Huang J.Q., Zheng G.F., Lai C.L., Yuen R.M.F. and Wong B.C.Y., Risk of liver cancer in patients with hepatitis B or C. Review, Hong Kong Mededical Journal. 2011, 17 (Suppl 6): 41-3.
Li Z., Chen J., Chan K.W., Qiao L. and Wong B.C.Y., A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Cancer Lett. 2011, 313(2): 192-200.
Ng F.H., Tunggal P., Chu W.M., Lam K.F., Li A., Chan K., Lau Y.K., Kng C., Keung K.K., Kwan A. and Wong B.C.Y., Esomeprazole Compared With Famotidine In The Prevention Of Upper Gastrointestinal Bleeding In Patients With Acute Coronary Syndrome Or Myocardial Infarction, The American Journal of Gastroenterology. Nature Publishing Group, 2012, 107: 389–396.
Tan V.P.Y., Wong R.W.M., Hung I.F.N. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., J Gastroenterol. 2011, 46(7):906-12.
Tan V.P.Y., Wong W.M., Cheung T.K., Lai K.C., Chan P., Pang R.W.C. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., In: T. Azuma, Journal of Gastroenterology. Wiley InterScience, 2011, 46(7): 906-12.
Tse M.K., Tse M.K., Hui S.K., Yang Y.H., Yin S.T., Hu H.Y., Zou B., Wong B.C.Y., Sze K.H. and Sze K.H., Structural analysis of the UBA domain of x-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association, PLoS one. 2011, 6: e28511 (1-14).
Wong B.C.Y. and Sung J.J., Colo-rectal Screening Around The World, Asia-pacific Region. Aga Perspectives, 2012, 8: 20.


Researcher : Wong CM
Project Title:Identification of the novel receptors for two liver-derived endocrine Factors FGF21 and adropin
Investigator(s):Wong CM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:The role of beta Klotho in regulation of metabolic homeostasis: Molecular Basis and Physiological Implications
Investigator(s):Wong CM, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012


List of Research Outputs

Kong K.Y., Tang H.M.V., Jin D. and Wong C.M., Yeast TRAMP complex facilitates pre-mRNA splicing, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.


Researcher : Wong DKH
Project Title:Identification of hepatitis B virus DNA polymerase sequences to predict virological response to entecavir therapy
Investigator(s):Wong DKH, Lai CL, Yuen RMF, Fung JYY
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:05/2009
Completion Date:11/2011


Project Title:Identification of aberrantly methylated CpG loci in hepatitis B virus-related hepatocellular carcinoma
Investigator(s):Wong DKH, Yuen RMF, Lai CL, Fung JYY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:09/2012


Project Title:Application of COLD-PCR sequencing for the early detection of HBV antiviral drug resistant mutations
Investigator(s):Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2010


List of Research Outputs

Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. {Epub 2010 Oct 19], J Hepatol. 2011, 54(2): 195-200.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Cho C.H. and Yuen R.M.F., Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1β activation of nitric oxide production in gastric cancer cells., Cancer. 2012.
Seto W.K., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Tang L., Pu Y., Wong D.K.H., Liu T., Tang H., Xiang T.X., Yuen R.M.F. and Ren G.S., The hepatitis B virus-associated estrogen receptor alpha (ER alpha) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells , Acta Biochimica Et Biophysica Sinica . 2011, 43 (Issue: 8): 640-646.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Wong D.K.H., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, State Key Laboratory for Liver Research Symposium 2011, HKU. 2011.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Wong HK
List of Research Outputs

Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 36.


Researcher : Wong KY
List of Research Outputs

Chim J.C.S., Wan T.S.K., Wong K.Y., Fung T.K., Drexler H.G. and Wong K.F., Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms, Journal of Translational Medicine. 2011, 197.
Wong K.Y., Huang X.J. and Chim J.C.S., DNA methylation of microRNA genes in multiple myeloma, Carcinogenesis. 2012, 33(9): 1629-38.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.


Researcher : Wong KYM
List of Research Outputs

Wong K.Y.M., Fung S.L., Lam C.L.D., Tam T.C., Lam C.M.J., Ho J.C.M. and Ip M.S.M., Adequacy of tissue obtained by semirigid pleuroscopy. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July 2011, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S1508 (P4.193).
Wong K.Y.M., Tam T.C., Lam C.L.D., Ip M.S.M. and Ho J.C.M., Endobronchial Ultrasound-guided aspiration in superior vena cava syndrome, Lung Cancer. 2012, Epub ahead of print.


Researcher : Wong LY
List of Research Outputs

Lai K.W.H., Ho J.C.Y., Ng J.H.L., Chan Y.C., Au K.W., Wong L.Y., Siu D.C.W. and Tse H.F., Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells, PLoS One (Submitted). 2012.
Siu D.C.W., Lee Y.K., Ho J.C.Y., Lai K.W.H., Chan Y.C., Ng K.M., Wong L.Y., Au K.W., Lau V.Y.M., Zhang J., Lay K.W.J., Colman A. and Tse H.F., Modeling of Familial Dilated Cardiomyopathy Caused by Mutation in Lamin A/C Gene Using Patient-Specific Induced Pluripotent Stem Cells. , Aging (In Revision). 2012.


Researcher : Wong LYF
Project Title:Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Wong RWM
List of Research Outputs

Tan V.P.Y., Wong R.W.M., Hung I.F.N. and Wong B.C.Y., Treatment Of Non-erosive Reflux Disease With A Proton Pump Inhibitor In Chinese Patients: A Randomized Controlled Trial., J Gastroenterol. 2011, 46(7):906-12.


Researcher : Wong RWS
List of Research Outputs

Chung H.Y., Lau W.C.S., Wu K.P., Wong R.W.S. and Mok T.M.Y., Comparison of performance of the Assessment of Spondyloarthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis., Clinical Rheumatology . 2011, 30(7): 947-953.
Li R., Yang W., Zhang J., Hirankarn N., Pan H.F., Mok C.C., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Lee T.L., Ho M.H.K., Lee P.P.W., Chan T.M., Wong W.H.S., Wong C.M., Ng I.O.L., Yang J., Li P.H., Zhang Y., Zhang L., Li W., Baum L., Kwan P., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S., Shen N., Lau Y.L. and Ye D.Q., Association of CD247 with systemic lupus erythematosus in Asian populations, Lupus. 2012, 21(1): 75-83.


Researcher : Wong Y
List of Research Outputs

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products (AGEs) are associated with insulin resistance, Diabetes Metab Res Rev. 2011, 27(5): 488-92.


Researcher : Wong YK
List of Research Outputs

Lau G.K.K., Wong Y.K., Yiu K.H., Siu D.C.W. and Tse H.F., Prognostic implications of non-invasive vascular markers in patients with type 2 diabetes - a 5 year prospective study , Seventh International Symposium on Healthy Aging. 2012.


Researcher : Woo YC
List of Research Outputs

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.


Researcher : Wu D
List of Research Outputs

Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.


Researcher : Wu DCG
List of Research Outputs

Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.


Researcher : Wu H
List of Research Outputs

Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Wu H. and Li G.R., The in-vitro cardioprotective effect of the natural flavone acacetin against ischaemia/reperfusion injury in rat hearts, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 59.
Wu H., Wu W., Sun H. and Li G.R., The natural flavone acacetin blocks kv4.3 current by interacting with P-loop filter helix of the channel, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Wu H
List of Research Outputs

Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Wu H. and Li G.R., The in-vitro cardioprotective effect of the natural flavone acacetin against ischaemia/reperfusion injury in rat hearts, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 59.
Wu H., Wu W., Sun H. and Li G.R., The natural flavone acacetin blocks kv4.3 current by interacting with P-loop filter helix of the channel, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Wu W
List of Research Outputs

He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.
Wu H., Wu W., Sun H. and Li G.R., The natural flavone acacetin blocks kv4.3 current by interacting with P-loop filter helix of the channel, Kong - Taiwan Physiology Symposium, June. 2012, 55.
Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.


Researcher : Wu X
List of Research Outputs

Wu W., Dong M., Wu X., Sun H., Tse H.F., Lau C.P. and Li G.R., Human ether-a-go-go gene potassium channels are regulated by EGFR tyrosine kinase., BBA-Mol Cell Res. 2012, 1823(2): 282-289.


Researcher : Xia HHX
Project Title:Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


Project Title:Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2005




Researcher : Xiao S
Project Title:Replication and Functional Study of Polymorphisms in miRNA Binding Sites and Osteoporosis
Investigator(s):Xiao S, Kung AWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011
Completion Date:08/2012


List of Research Outputs

Cheung C.L., Xiao S., Lau K.S., Bow C.H.Y., Gao Y., Sham P.C., Tan K.C.B. and Kung A.W.C., Meta-Analysis of Gene-based Genome Wide Association Studies of Bone Mineral Density in Chinese and European, Osteoporosis International . 2011.
Guo Y., Baum L.W., Sham P.C., Wong V.C.N., Ng P.W., Lui C.H.T., Sin N.C., Tsoi T.H., Tang C.S.M., Kwan S.H., Yip B.H.K., Xiao S., Thomas G.N., Lau Y.L., Yang W., Cherny S.S. and Kwan P., Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese, Human Molecular Genetics. 2011, 21: 1184-1189.
Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011.
Xiao S., Kung A.W.C., Gao R.Y., Lau K.S., Ma C.H., Zhang Z.L., Liu J.M., Xia W., He J.W. and Zhao L., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density, Human Molecular Genetics. 2011.


Researcher : Xiong J
Project Title:2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):Xiong J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2008




Researcher : Xu A
Project Title:Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2007


Project Title:Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
Investigator(s):Xu A, Lam KSL, Vanhoutte PMGR, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2008


Project Title:Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
Investigator(s):Xu A, Vanhoutte PMGR, Lam KSL
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2009
Completion Date:12/2011


Project Title:Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:12/2011


Project Title:Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2011


Project Title:Protective effects of the liver-derived hormone adropin against obesity-related insulin resistance and metabolic disorders
Investigator(s):Xu A, Wang Y
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011
Completion Date:04/2012


Project Title:71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2011


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Vanhoutte PMGR, Wang Y, Lam KSL
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2011


Project Title:The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:The Ubiquitin Ligase Mdm2 as a Novel Regulator of Adipose Functions and Obesity
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:EDHF 2012 ENDOTHELIUM-SELECTIVE ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE IMPROVES RE-ENDOTHELIALIZATION AND VASCULAR FUNCTION VIA INDUCTION OF HEME OXYGENASE-1 IN DIABETIC MICE
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Chen C., Cheung B.M.Y., Tso A.W.K., Wang Y., Law S.C., Ong K.L., Wat N.M.S., Xu A. and Lam K.S.L., High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects, Diabetes Care 2011. 2011, 34 (9): 2113-2115.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study., Clinical Endocrinology (Oxford). 2012, 76 (4): 506-13.
Chen C., Tso A.W.K., Cheung B.M.Y., Law S.C., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study, Clin Endocrinol (Oxf). 2012, 76(4): 506-13.
Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H., Lam K.S.L. and Xu A., Growth Hormone Induces Hepatic Production Of Fibroblast Growth Factor 21 Through A Mechanism Dependent On Lipolysis In Adipocytes., Journal of Biological Chemistry. 2011, 286: 34559-66.
Chen W., Hoo R.L.C., Konishi M., Itoh N., Ye H.Y., Lam K.S.L. and Xu A., Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes., J Biol Chem. 2011, 286: 34559-66.
Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012.
Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012.
Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Cheng K.Y., Lam K.S.L., Wang Y., Wu D. and Xu A., Disruption of APPL1 exacerbates high-fat diet-induced insulin resistance and impairment of insulin secretion in mice, Asia Islet Biology & Incretin Symposium 2011.
Cheng K.Y., Lam K.S.L. and Xu A., The E3 ligase TRAF6 regulates the insulin-sensitizing actions of the adaptor protein APPL1 through ubiquitination., Ubiquitin and ubiquitin like modifiers, 2011. . 2011.
Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Xu A., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort, Journal of Human Hypertension 2012. 2012, 26: 108-116.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study, PLoS One. 2011, 6 (12): e28598.
Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-term Prospective Study, PLoS One. 2011, 6(12): e28598.
Cleasby M.E., Lau Q., Polkinghorne E., Patel S.A., Leslie S.J., Turner N., Cooney G.J., Xu A. and Kraegen E.W., The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway, J Endocrinol. 2011, 210(1): 81-92.
Fan P., Song E., Xu A., Feletou M., Vilaine J.P., Vanhoutte P.M.G.R. and Huang Y., Elevated 20-Hete contributes to the improved endothelial function in lipocalin-2 deficient mice, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 16.
Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Hoo R.L.C., Lee P.C., Cheng K.Y., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein mediates toxic-lipids-induced endoplasmic reticulum stress through inhibition of JAK-dependent autophagy, 7th International Symposium on Heathy Aging "Live Well Age Well", Research Centre of Heart, Brian, Hormone & Healthy Aging.. 2012.
Hoo R.L.C., Lee P.C., Lam K.S.L. and Xu A., Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via its inhibition of autophagy, 17 th Medicial Research Conference. 2012.
Hoo R.L.C., Wong J.Y., Qiao C., Xu H., Xu A. and Lam K.S.L., An effective fraction isolated from Radix Astragali alleviates glucose tolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, The 5th International Conference on Diabetes, Teaching Hospital of Chengdu Unviersity of Traditional Chinese Medicine. 2012.
Hoo R.L.C., Wong J.Y., Lam K.S.L. and Xu A., The Role of Adipocyte Fatty Acid Binding Protein (A-FABP) in the Pathogenesis of Obesity-related Inflammatory Diseases. , Sixth International Symposium on Healthy Aging, 2011.. 2011.
Hui X., Zhang M., Lam K.S.L. and Xu A., Adipocyte-Selective Disruption of SIRT1 Accelerates High Fat Diet and Aging induced Systemic Insulin Resistance via Modulation of Macrophage Infiltration and Polarization, 7th International Symposium on Healthy Aging. 2012.
Hui X., Lam K.S.L. and Xu A., Adipocyte-selective disruption of SIRT1 accelerates high fat diet and aging induced insulin resistance by modulation of macrophage infiltration and polarization, 17th Medical Research Conference. 2012.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update., Br J Pharmacol. 2012, 165(3): 574-90.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update, British Journal of Pharmacology. 2012, 165: 574-590.
Ji Y., Sun S., Xu A., Bhargava P., Yang L., Lam K.S.L., Gao B., Lee C.H., Kersten S. and Qi L., Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity, J Biol Chem. 2012, 287(17): 13561-71.
Lee P.C.H., Chow W.S., Yuen M.A.M., Tso A.W.K., Xu A., Law S.C., Cheung S.C.W., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin levels are predictive of carotid intima-medial thickness in a 5-year community-based prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 32.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Best Abstract in Basic Science and Translational Medicine, 17th Medical Research Conference. 2012.
Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and EPC mobilisation in mice, 17th Medical Research Conference. 2012.
Li H., Hui X., Wang Y. and Xu A., High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli , Protein Expression and Purification. 2011.
Li H., Gao Z., Zhang J., Ye X., Xu A., Ye J. and Jia W., Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3, Diabetes. 2012, 61(4): 797-806.
Li J., Li F.Y.L., Xu A., Cheng B., Tsao G.S.W., Fung M.L. and Leung W.K., Lipopolysaccharide and Hypoxia Induce HIF-1 Activation in Human Gingival Fibroblasts, Journal of Periodontology. 2011, 1-8.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgrad Med . 2011, 123(6): 66-71.
Li M., Xu A., Lam K.S.L., Cheung B.M.Y. and Tse H.F., Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin, Postgraduate Medicine. 2011, 123(6): 66-71.
Liang Y., Xu A. and Wang Y., Selective activation of AMPK in eddothelial cells intensifies high fat diet-induced non-alcoholic fatty liver disease, Journal of Hepatology of The International Liver Congress 2012, Barcelona Spain, April 18-22, 2012. 56: S493.
Liu L., Siu A.F.M., Che C.M., Xu A. and Wang Y., Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins, American Journal of Translational Research. 2012, 4: 175-186.
Ong K.L., Tso A.W.K., Xu A., Li M., Wat N.M.S., Rye K.A., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years, Diabetologia 2011. 2011, 54: 2552-2560.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Tang E.H.C., Libby P., Vanhoutte P.M.G.R. and Xu A., Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases, J Cardiovasc Pharmacol. 2012, 59(2): 116-23.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue. , Journal of Vascular Research . 2012, 49: 1-54.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 46.
Tian X.Y., Wong W.T., Xu A., Lu Y., Zhang Y., Wang L., Cheang W.S., Wang Y., Yao X. and Huang Y., Uncoupling protein-2 protects endothelial function in diet-induced obese mice, Circ Res. 2012, 110(9): 1211-6.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac Adiponectin content and reduce myocardial reperfusion injury In diabetic rats , PLoS ONE. 2011, 6(8): e23967.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Ng J.K.F., Xu A., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats, PLoS One. 2011, 6(8): e23967.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PLoS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Fong H.Y., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction, PloS One. 2012, 7(5): e36868.
Woo Y.C., Tso A.W.K., Xu A., Law S.C., Lam T.H., Lo S.V., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 57.
Xiang Y., Zhou P., Li X., Huang G., Liu Z., Xu A., Leslie R.D. and Zhou Z., Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China, Diabetes Care. 2011, 34(7): 1639-41.
Xiao Y., Xu A., Law S.C., Chen C., Li H., Li X., Yang L., Liu S., Zhou Z. and Lam K.S.L., Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes, J Clin Endocrinol Metab. 2012, 97(1): E54-8.
Xu A. and Vanhoutte P.M.G.R., Adiponectin and adipocyte fatty acid binding protein in the pathogensis of cardiovascular disease, American Journal of Physiology - Heart and Circulatory Physiology. 2012, 302: H1231-H1240.
Xu A., Endothelium-selective activation of AMP-activated protein kinase improves re-endothelialization and vascular function via induction of heme oxygenase-1 in diabetic mice, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012.
Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Anti-aging effects of SIRT1 in adipose tissue, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 1.21.
Xu G., Ahn J., Chang S., Eguchi M., Ogier A., Han S., Park Y., Shim C., Jang Y., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, J Biol Chem. 2012, 287(7): 4808-17.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.
Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Xu J
Project Title:Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese
Investigator(s):Xu J, Lam KSL, Sham PC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004




Researcher : Yam IYL
List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.


Researcher : Yan G
List of Research Outputs

Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.


Researcher : Yan S
List of Research Outputs

Chan V.S.F., Nie Y.J., Shen N., Yan S., Mok T.M.Y. and Lau W.C.S., Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus, Autoimmunity Reviews. 2012, Epub ahead of print.


Researcher : Yap YHD
List of Research Outputs

Chan J.C., Yap Y.H.D., Shea Y.F., Yuen C.K. and Yeung C.K., A highly contagious psoriasiform eruption on the scalp of a patient with systemic lupus erythematosus, J. Clin. Rheumatol.. 2012, 18: 144-5.
Chong Y.B., Yap Y.H.D., Tang S.O.C. and Chan D.T.M., Dyslipidemia in patients with lupus nephritis., Nephrology (Carlton). 2011, 16: 511-7.
Ma M.K., Yap Y.H.D. and Tang S.C.W., Transplant kidney herniation in an elderly patient., Nephrology (Carlton). 2011, 16: 511-7.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Binding of serum IgG to human mesangial cells and its correlation with disease activity in patients with lupus nephritis, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yap Y.H.D., Hwang Y.Y., Lam J.K. and Tang S.C.W., Gas in the renal shadow of a plain abdominal X-ray: emphysematous pyelonephritis, Nephrology (Carlton). 2012, 16: 119-20.
Yap Y.H.D., Yu X., Chen X.M., Lu F., Chen N., Li X.W., Tang C.S. and Chan D.T.M., Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome, Nephrology (Carlton). 2012, 17: 352-7.
Yap Y.H.D., Chu W.L., Ng F., Yip T.P.S., Lui S.L. and Lo W.K., Risk factors and outcome of contamination in patients on peritoneal dialysis - a single-centre experience of 15 years, Perit. Dial. Int.. 2012.
Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Ruptured abdominal aortic aneurysm as a cause of spontaneous hemoperitoneum in a patient on peritoneal dialysis, Perit. Dial. Int.. 2011, 31: 600-2.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Serum IgG binding to human mesangial cells in patients with lupus nephritis and its correlation with disease activity, Journal of the American Society of Nephrology. 2011.
Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.


Researcher : Ye D
List of Research Outputs

Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.


Researcher : Yeung CK
Project Title:HLA-B* 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong
Investigator(s):Yeung CK, Tang SCW, Cheung BMY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2012


List of Research Outputs

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.
Lee C.H., Yuen M.M.A., Chow W.S., Tso A.W.K., Yeung C.K., Chan J.C.Y., Chau C.H. and Lam K.S.L., A man with a blistering eruption and tuberculosis, BMJ. 2012, 344: d8351.
Yiu K.H., Yeung C.K., Zhao C.T., Chan J.C., Siu D.C.W., Tam S., Wong C.S., Yan G.H., Yue W.S., Khong P.L., Cha H. and Tse H.F., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis., J Intern Med. 2012.


Researcher : Yeung HM
List of Research Outputs

Li S., Yeung H.M., Kong M.C.W. and Li R.A., Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes., Days of Molecular Medicine, 2011.


Researcher : Yeung SC
List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cellular mechanisms involved in intermittent hypoxia-induced heart damage in rat, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 23.
Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64.
Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.
Mak J.C.W., Han Q., Yeung S.C. and Ip M.S.M., Effects of intermittent hypoxia on the expression levels of fatty acid-binding protein in rat heart, Am J Respir Crit Care Med. 2012, 185: A3869.


Researcher : Yeung SC
List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Cheung C.L., Tan K.C.B., Bow C.H.Y., Soong S.S., Yeung S.C., Loong C.H. and Kung A.W.C., Low Handgrip Strength is a Novel Predictor of Osteoporotic Fractures: Cross-sectional and Prospective Evidence from the Hong Kong Osteoporosis Study, Age. 2011.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cellular mechanisms involved in intermittent hypoxia-induced heart damage in rat, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 23.
Ho Y.S., Yang X., Yeung S.C., Lau C.F., Tsang A.W., Mak J.C.W., Chang R.C.C. and Wuwongse S., Cigarette smoking accelerated brain aging and induced Alzheimer-like neurodegeneration in rats, 7th International Symposium on Healthy Aging. 2012, 64.
Ho Y.S., Yang X., Yeung S.C., Chiu K., Lau C.F., Tsang A.W., Mak J.C.W. and Chang R.C.C., Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats, PLoS ONE. 2012, 7(5): e36752.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Am J Respir Crit Care Med. 2012, 185: A6409.
Li X., Yeung S.C., Lau K.W., Ip M.S.M. and Mak J.C.W., Age-dependent alterations of cigarette smoke-induced oxidative and inflammatory responses in rats, Hong Kong Medical Journal. 2012, 18 (Suppl. 1): 39.
Mak J.C.W., Han Q., Yeung S.C. and Ip M.S.M., Effects of intermittent hypoxia on the expression levels of fatty acid-binding protein in rat heart, Am J Respir Crit Care Med. 2012, 185: A3869.


Researcher : Yik PY
List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.


Researcher : Yim ASY
List of Research Outputs

Yung S.S.Y., Ng K.F., Yim A.S.Y., Ma M., Lui S.L. and Chan D.T.M., Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate, Journal of the American Society of Nephrology. 2011.


Researcher : Yim LY
List of Research Outputs

Tso H.W., Yim L.Y., Lau K.L.K., Li R.A. and Chan C.W.Y., Distinct immunomodulatory effect of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells, Re-engineering Regenerative Medicine 2012. 2011.


Researcher : Yim RLH
List of Research Outputs

Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.
Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.


Researcher : Yip MCP
List of Research Outputs

Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.


Researcher : Yip TPS
List of Research Outputs

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients, Peritoneal Dialysis International. 2011, 31(5): 522-8.


Researcher : Yiu CW
List of Research Outputs

Ho W.L., Ho W.M., Tse H.M., So H.F., Yiu C.W., Liu H., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells, PLoS ONE. 2012.


Researcher : Yiu KH
Project Title:Mechanism and Reversibility of Myocardial Fibrosis in Patients with Diabetic Cardiomyopathy: Role of Aliskiren.
Investigator(s):Yiu KH, Lam KSL, Tse HF, Wang MM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


List of Research Outputs

Chan H.T., Yiu K.H., Li S.W., Wong C.Y., Lam S. and Tse H.F., Increased dietary fruit intakes was associated with lower burden of carotid atherosclerosis in patients with Type 2 diabetes mellitus. , Diabetic Med. 2012.
Chan Y.H., Siu D.C.W., Yiu K.H., Li L.S.W., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Abnormal vascular function in PR-interval prolongation, Clinical Cardiology. 2011, 34(10): 628-632.
Chan Y.H., Siu D.C.W., Yiu K.H., Chan H.T., Li L.S.W., Tam S., Cheung B.M.Y., Lau C.P., Lam T.H. and Tse H.F., Adverse systemic arterial function in patients with selenium deficiency, Journal of Nutrition, Health & Aging. 2012, 16(1): 85-88.
Chan Y.H., Siu D.C.W., Yiu Y.F., Yiu K.H., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR Prolongation is Associated with Endothelial Dysfunction and Vascular Repair Activation in High Risk Cardiovascular Patients, American Heart Association Scientific Session, Orlando. 2011.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., PR interval prolongation is independently associated with increased carotid intima-media thickness: novel pathophysiological, clinical and preventive implications, Seventh International Symposium on Healthy Aging. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Chan H.T., Li L.S.W., Tam S., Lam T.H., Lau C.P. and Tse H.F., Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function, Journal of Nutrition, Health & Aging. 2012, 16(4): 383-388.
Jim M.H., Ho H.H., Yiu K.H. and Siu D.C.W., Angiographic and long-term clinical outcome of the sleeve technique in treating in-stent restenotic bifurcation lesions: a preliminary experience., Acute Card Care. 2011, 13(3): 159-63.
Lau G.K.K., Yue W.S., Yiu K.H., Siu D.C.W., Wang M.M., Yan G.H. and Tse H.F., Best Abstract in Basic Science & Translational: Impact of Glycaemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2012.
Lau G.K.K., Wong Y.K., Yiu K.H., Siu D.C.W. and Tse H.F., Prognostic implications of non-invasive vascular markers in patients with type 2 diabetes - a 5 year prospective study , Seventh International Symposium on Healthy Aging. 2012.
Lau K.K., Wong Y.K., Chan Y.H., Yiu K.H., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes., Cardiovasc Diabetol. 2012.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., Li S.W., Fong B., Wong W.K., Tam S. and Tse H.F., Lower habitual physical activity was associated with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease., Cir J 2012. 2012.
Ng A.C., Yiu K.H., Ewe S.H., van der K.L.E.Y. .F., Bertini M., de Weger A., de Roos A., Leung D.Y., Schuijf J.D., Schalij M.J., Bax J.J. and Delgado V., Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation, . Eur Heart J. 2011, 32: 2806-13.
Witkowski T.G., Thomas J.D., Delgado V., van Rijnsoever E., Ng A.C., Hoke U., Ewe S.H., Auger D., Yiu K.H., Holman E.R., Klautz R.J., Schalij M.J., Bax J.J. and Marsan N.A., Changes in left ventricular function after mitral valve repair for severe organic mitral regurgitation. , Ann Thorac Surg.. 2011, 63: 3969-78.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yan G., Wang M.M., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex, AHA, . 2011.
Yiu K.H., Schouffoer A.A., Marsan N.A., Ninaber M.K., Stolk J., Vlieland T.V., Scherptong R.W., Delgado V., Homlan E.R., Tse H.F., Huizinga T.W., Bax J.J. and Schuerwegh A.J., Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: Relationship to functional capacity and ventricular arrhythmias. , Arthritis Rheum.. 2011, 63: 3969-78.
Yiu K.H., de Graaf F.R., Schuijf J.D., van Werkhoven J.M., Marsan N.A., Veltman C.E., de Roos A., Pazhenkottil A., Kroft L.J., Boersma E., Herzog B., Leung M., Maffei E., Leung D.Y., Kaufmann P.A., Cademartiri F., Bax J.J. and Jukema J.W., Age- and gender-specific differences in the prognostic value of CT coronary angiography. , Heart. 2012, 98: 232-7.
Yiu K.H., Tse H.F., Mok T.M.Y. and Lau W.C.S., Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. , Nat Rev Rheumatol.. 2011, 7: 609-18.
Yiu K.H., Marsan N.A., Delgado V., Biermasz B.R., Holman E.R., Smit J.W., Feelders R.A., Bax J.J. and Pereira A.M., Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. , Eur J Endocrinol. 2012, 166: 27-34.
Yiu K.H., International Congress of Cardiology-ICC 2009 (Shanghai) December 5-7, 2009. Talk: Current Perspective of Myocarditis, 2011.
Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients after elective percutaneous coronary intervention. , Cardiovasc Diabetol.. 2011, 10: 52.
Yiu K.H., Atsma D.E., Delgado V., Ng A.C., Witkowski T.G., Ewe S.H., Auger D., Holman E.R., van M.I.L. .A.M., Breuning M.H., Tse H.F., Bax J.J., Schalij M.J. and Marsan N.A., Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers., Plos One. 2012, 7: e36115.
Yiu K.H., Yeung C.K., Zhao C.T., Chan J.C., Siu D.C.W., Tam S., Wong C.S., Yan G.H., Yue W.S., Khong P.L., Cha H. and Tse H.F., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis., J Intern Med. 2012.
Yiu K.H., Mok T.M.Y., Wang S., Ooi C.G.C., Khong P.L., Lau C.S. and Tse H.F., Prognostic role of coronary calcification in patients with rheumatoid arthritis and systemic lupus erythematosus, Clinical and Experimental Rheumatology . 2012, 30: 345-350.
Yiu K.H., de Graaf F.R., Schuijf J.D., van Werkhoven J.M., van Velzen J.E., Boogers M.J., Roos C.J., de Bie M.K., Pazhenkottil A., Kroft L.J., Boersma E., Herzog B., de Roos A., Kaufmann P.A., Bax J.J. and Jukema J.W., Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography, Am J Cardiol. 2011 . 2011, 108(7): 968-72.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M., Yan G.H., Yiu K.H. and Tse H.F., Impact of Glycemic Control on Circulating Endothelial Progenitor Cells and Arterial Stiffness in Patients with Type 2 Diabetes Mellitus , Cardiovascular Diabetology. 2011, 10(1):113.
Yue W.S., Lau G.K.K., Siu D.C.W., Wang M.M., Yan G.H., Yiu K.H. and Tse H.F., Impact of glycaemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18: 63.


Researcher : Yiu KYK
List of Research Outputs

Auger D., Bertini M., Marsan N.A., Hoke U., Ewe S.H., Thijssen J., Witkowski T.G., Yiu K.Y.K., NG A.C., van de Wall E.E., Schalij M.J., Bax J.J. and Delgado V., Prediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchrony., Am J Cardiol. 2011, 108: 711-7.


Researcher : Yiu WH
Project Title:Functional role of protease activated receptors (PARs) in mediating inflammation and fibrosis in diabetic nephropathy (DN)
Investigator(s):Yiu WH, Tang SCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2012


List of Research Outputs

Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Amelioration of albuminuria and tubulointerstitial inflammation in STZ-induced diabetic TLR4-deficient mice, J Am Soc Nephrol . 2011, 21: 466A.
Lin M., Yiu W.H., Wu H., Chan Y.Y., Leung J.C.K., Au W.S., Chan K.W., Lai K.N. and Tang S.C.W., Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy, Journal of the American Society of Nephrology. 2012, 23: 86-102.
Wu H., Yiu W.H., Leung J.C.K., Chan Y.Y., Lian Q., Lin M., Tse H.F., Lai K.N. and Tang S.C.W., Human bone marrow derived mesenchymal stromal/stem cells attenuate tubular inflammation upon albumin challenge, J Am Soc Nephrol . 2011, 21: 135A.
Yiu W.H., Leung J.C.K., Chan Y.Y., Lan H.Y., Lai K.N. and Tang S.C.W., High glucose promotes renal tubular CTGF expression via the activation of protease-activated receptors, ASN Kidney Week 2011 Annual Meeting. 2011.


Researcher : Young JLP
List of Research Outputs

Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.


Researcher : Yue W
List of Research Outputs

Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Yan G., Wang M.M., Yue W., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Fragmented QRS is associated with intraventricular systolic dyssynchrony in CAD patients with a narrow QRS interval , ESC Congress . 2011.
Yan G., Wang M.M., Yue W., Zhi G., Yiu K.H., Lau C.P., Lee S.W.L., Siu D.C.W. and Tse H.F., Relationship between Ventricular Dyssynchrony and T-wave Alternans in Patients with Coronary Artery Disease , PACE. 2011.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.


Researcher : Yuen JCH
List of Research Outputs

Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.
Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. {Epub 2010 Oct 19], J Hepatol. 2011, 54(2): 195-200.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.


Researcher : Yuen KY
Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Discovery and characterization of novel microbes with epidemic potential
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:01/2007


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Internal Award for CAE Membership
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Internal Award for Chinese Academy of Engineering Membership
Start Date:02/2008


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Infection and Immunology
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2008


List of Research Outputs

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.


Researcher : Yuen MF
Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Genetic and epigenetic analyses of occult hepatitis B virus infection
Investigator(s):Yuen RMF, Fung JYY, Lai CL, Wong DKH, Yao T
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2011


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs



Researcher : Yuen RMF
Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Genetic and epigenetic analyses of occult hepatitis B virus infection
Investigator(s):Yuen RMF, Fung JYY, Lai CL, Wong DKH, Yao T
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2011


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs

Ahn S.H., Kweon Y.O., Paik S.W., Sohn J.H., Lee K.S., Kim D.J., Piratvisuth T., Yuen R.M.F., Chutaputti A., Chao Y.C., Trylesinski A. and Avila C., Telbivudine in combination with adefovir versus adefovir monotherapy in HBeAg-positive, lamivudine-resistant chronic hepatitis B. [Epub ahead of print], Hepatolo Int. 2011.
Chan K., Yam I.Y.L., Yuen J.C.H., Yuen R.M.F., Lai C.L., Alexander G.J., Chan T.K. and Chan V.N.Y., A comprehensive HBV array for the detection of HBV mutants and genotype, Clinical Biochemistry. 2011, 44: 1253-60.
Chan Y.K., Wong C.M., Kwan S.H., Lee M.F., Cheung K.W., Yuen R.M.F., Lai C.L., Poon R.T.P., Sham P.C. and Ng I.O.L., Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection, PLoS One. 2011, 6(12): e28798.
Cheung F., Feng Y., Wang M.N., Yuen R.M.F., Tong Y. and Wong V.C.W., Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials., Chin Med, 2012, 7(1):5.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Defining Normal Liver Stiffness Values In A Large Population of Chinese Subjects Without Liver Disease , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp: 1): 1146A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Sharr W.W., Chan A.C.Y., Dai W.C., Cheung T.T., Fan S.T., Lai C.L., Yuen R.M.F. and Lo C.M., Entecavir Versus Lamivudine Prophylaxis without Hepatitis B Immune Globulin after Liver Transplantation for Chronic Hepatitis B., 18th Annual International Congress on ILTS Location: San Francisco, USA. May 16-19, 2012. Liver Transplantation.. 2012, 18 (supp 1): S124.
Fung J.Y.Y., Cheung C.K.Y., Chan S.C., Yuen R.M.F., Chok K.S.H., Sharr W.W., Dai W.C., Chan A.C.Y., Cheung T.T., Tsang S.H.Y., Lam B.K.Y., Lai C.L. and Lo C.M., Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation, Gastroenterology. 2011, 141(4): 1212-1219.
Fung J.Y.Y., Chan S.C., Yuen R.M.F., Lai C.L., Chok K.S.H., Sharr W.W., Dai W.C., Fan S.T. and Lo C.M., Long-term Outcome of Lamivudine Mono-prophylaxis After Liver Transplantation In Hepatitis B Patients , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 450A-450A.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B. Epub 2011 Sep 29. Review., J Antimicrob Chemother . 2011, 66(12): 2715-25.
Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. {Epub 2010 Oct 19], J Hepatol. 2011, 54(2): 195-200.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B , Journal Of Viral Hepatitis . 2011, 18( Issue: 10): 738-744.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Quantitative Hepatitis B Surface Antigen Levels in Patients With Chronic Hepatitis B After 2 Years of Entecavir Treatment, American Journal of Gastroenterology. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment, Am J Gastroenterol. 2011, 106(10): 1766-73.
Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K.W., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study , Journal of Viral Hepatitis . 2011, 18 (Issue: 7): E200-E205.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: Implications for studies using stored sera, Journal of Medical Virology. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Young J.L.P., Wong D.K.H., Yuen J.C.H., Seto W.K.W. and Yuen R.M.F., Stability of hepatitis B surface antigen over time: implications for studies using stored sera, J Med Virol. 2011, 83(11): 1900-4.
Fung J.Y.Y., Lai C.L., Seto W.K.W. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B , Hepatology International . 2011, 5(4): 868-875.
Huang F.Y., Chan A.O.O., Rashid A., Wong D.K.H., Cho C.H. and Yuen R.M.F., Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1β activation of nitric oxide production in gastric cancer cells., Cancer. 2012.
Huang J.Q., Zheng G.F., Lai C.L., Yuen R.M.F. and Wong B.C.Y., Risk of liver cancer in patients with hepatitis B or C. Review, Hong Kong Mededical Journal. 2011, 17 (Suppl 6): 41-3.
Kurosaki M., Yuen R.M.F., Seto W.K.W., Kumada T., Tanaka K., Suzuki Y., Hoshioka Y., Tarnaki N., Kato T., Yasui Y., Hosokawa T., Ueda K., Tsuchiya K., Kuzuya T., Nakanishi H., Itakura J., Takahashi Y., Asahina Y. and Izumi N., Generation of the prediction models for the development of hepatocellular carcinoma in chronic hepatitis B and external validation by independent cohorts, J Hepatol. 2011, 54(Suppl 1): S150-1.
Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.H., Kweon Y.O., Sohn J.H., Lee J., Kim J.A., Han K.H. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54(Suppl:1): 1442A.
Lai C.L., Ahh S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.H., Kweon Y.O., Sohn J.H., Lee J., Kim J.A., Han K.H. and Yuen R.M.F., Week 48 Analysis Of A Phase Iib Study Of The Efficacy And Safety Of Lb80380 Vs. Entecavir In Treatment-naive Patients With Chronic Hepatitis B, 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology. 2011, 54(Supp: 1): 1442A.
Lam Y.F., Yuen R.M.F., Seto W.K.W. and Lai C.L., Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety., Current Hepatitis Reports. 2011, 10(4): 235-243.
Sawai H., Nishida N., Mbarek H., Matsuda K., Mawatari Y., Yamaoka M., Hige S., Kang J.H., Abe K., Mochida S., Watanabe M., Kurosaki M., Asahina Y., Izumi N., Honda M., Kaneko S., Tanaka E., Matsuura K., Itoh Y., Mita E., Korenaga M., Hno K., Murawaki Y., Hiasa Y., Ide T., Ito K., Sugiyama M., Ahn S.H., Han K.H., Park J.Y., Yuen R.M.F., Nakamura Y., Tanaka Y., Mizokami M., Mizokami M. and Tokunaga K., No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations., BMC Med Genet. 2012, 19: 13-47.
Seto W.K., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L., Hung I.F.N. and Yuen R.M.F., A Large Population Histology Study Showing The Lack Of Association Between Alt Elevation And Significant Fibrosis In Chronic Hepatitis B., PLoS One. 2012, 7(2):e32622.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance., Hepatology. 2012.
Seto W.K.W., Lee C.F., Lai C.L., Ip P.P.C., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen R.M.F., A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B, PLoS One. 2011, 6(8): e23077.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Acute-on-chronic liver failure in chronic hepatitis B., Journal of Gastroenterology and Hepatology. 2012, 27(4): 662-9.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong S.M., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance, Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl: 1): 1070A.
Seto W.K.W., Lai C.L. and Yuen R.M.F., Nucleic acid testing for the detection of HBV DNA., Hepatitis Monthly. 2011, 11(10): 847-8.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Poster presentation at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases; The Liver Meeting 2011, San Francisco, California, USA, November 4-8, 2011. Hepatology. 2011, 54 (Suppl:1): 1068A-1069A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Yuen J.C.H., Hung I.F.N., Lai C.L., Lai C.L. and Yuen R.M.F., Serologic And Virologic Kinetics After Stopping Nucleoside Analogue Therapy In Hepatitis B Surface Antigen (hbsag) Seroclearance , 47th Annual Meeting Of The European-association-for-the-study-of-the-liver (easl) Location: Barcelona, Spain. April 18-22, 2012. Journal Of Hepatology. 2012, 56(Supplement: 2 ): S214-S215.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Young J.L.P., Tong S.M., Hung I.F.N. and Yuen R.M.F., Serum Hepatitis B Surface Antigen (hbsag) Titers And Hbv Dna Levels In Hepatitis B E Antigen (hbeag)-negative Chronic Hepatitis B: An Interim Analysis , 62nd Annual Meeting Of The American-association-for-the-study-of-liver-diseases (AASLD) Location: San Francisco, USA. November 04-08, 2011. Hepatology . 2011, 54(Supp 1): 1077A.
Seto W.K.W., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome , Journal of Hepatology . 2011, 55 (Issue: 3): 522-528.
Tang L., Pu Y., Wong D.K.H., Liu T., Tang H., Xiang T.X., Yuen R.M.F. and Ren G.S., The hepatitis B virus-associated estrogen receptor alpha (ER alpha) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells , Acta Biochimica Et Biophysica Sinica . 2011, 43 (Issue: 8): 640-646.
Tung K.K., Mak K.M., Fatima S., Lo C.L.R., Zhao H., Zhang C., Dai H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J.J., Luk J.M.C. and Ng I.O.L., Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma, Liver International. 2011, 31(10): 1494-1504.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels, Hepatology International (Oral presentation at the 22nd Conference of the Asian Pacific Association for the Study of the Liver; 16-19 February 2012, Taipei). 2012, 6: 7.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-836.
Wong D.K.H., Huang F.Y., Lai C.L., Poon R.T.P., Seto W.K.W., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2011, 54(3): 829-36.
Yuen R.M.F., Entecavir: Clinical update and Hong Kong real-life study, Web conference to Portugal (5 cities) 13th, 17th, 19th October, 15th, 23rd November, 2011.. 2011.
Yuen R.M.F., How to we optimize the use of new and evolving management tools for chronic hepatitis B treatment?, Asia Hepatology Perspectives Forum. Long-term Treatment and Disease Outcomes in Chronic Hepatitis B, 26th – 27th November, 2011.. 2011.
Yuen R.M.F., Interleukin-28B in chronic hepatitis C, Hong Kong Medical Forum, 12th – 13th May 2012.. 2012.
Yuen R.M.F., Seto W.K.W., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three Years of Continuous Entecavir Therapy in Treatment-Naive Chronic Hepatitis B Patients: VIRAL Suppression, Viral Resistance, and Clinical Safety , American Journal of Gastroenterology . 2011, 106 (Issue: 7): 1264-1271.
Zhao Q., Peng L., Huang W., Li Q., Pei Y., Yuan P., Zheng L., Zhang Y., Deng J., Zhong C., Hu B., Ding H., Fang W., Li R., Liao Q., Lin C., Deng W., Yan H., Hou J., Wu Q., Xu T., Liu J., Hu L., Peng T., Chen S., Lai K.N., Yuen R.M.F., Wang Y., Maini M.K., Li C., Li M., Wang J., Zhang X., Zhang X., Sham P.C., Wang J., Gao Z.L. and Wang Y., Rare inborn errors associated with chronic hepatitis B virus infection., Hepatology. 2012.


Researcher : Yung SSY
Project Title:The role of decorin in peritoneal inflammation and fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:The effect of heparin on inflammatory and fibrotic processes in human mesothelial cells during peritoneal dialysis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2010
Completion Date:02/2012


Project Title:The role of TGF-beta1 and phosphatidylinositol 3-kinase activation on perlecan synthesis in mesangial cells
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


Project Title:2nd International Conference on Immune Tolerance Binding of anti-dsDNA antibodies to human proximal tubular epithelial cells induces IL-6 and MCP-1 secretion through MAPK phosphorylation
Investigator(s):Yung SSY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:10/2011


Project Title:The role of annexin II and IL-6 in peritoneal inflammation and fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


List of Research Outputs

Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., 4-methylumbelliferone suppresses hyaluronan synthesis in NZB/W F1 mice and reduces immune-mediated renal inflammation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Suppression of hyaluronan synthesis with 4-methylumbelliferone in NZB/W F1 mice is associated with reduced renal inflammation and renal function improvement, Journal of the American Society of Nephrology. 2011.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Binding of serum IgG to human mesangial cells and its correlation with disease activity in patients with lupus nephritis, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Serum IgG binding to human mesangial cells in patients with lupus nephritis and its correlation with disease activity, Journal of the American Society of Nephrology. 2011.
Yung S.S.Y. and Chan D.T.M., Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis : getting to know the unknown, Clinical and Developmental Immunology. 2012.
Yung S.S.Y., Ng Y.C.C. and Chan D.T.M., Binding of anti-dsDNA antibodies to human proximal tubular epithelial cells induces IL-6 and MCP-1 secretion through MAPK phosphorylation, 2nd International Conference on Immune Tolerance, Amsterdam, The Netherlands. 2011.
Yung S.S.Y., Ng K.F., Yim A.S.Y., Ma M., Lui S.L. and Chan D.T.M., Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate, Journal of the American Society of Nephrology. 2011.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of hyaluronan synthesis with 4-methylumbelliferone in NZBWF1/J mice is associated with improved renal function and reduced renal inflammation, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yung S.S.Y. and Chan D.T.M., Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells, Mediators of Inflammation. 2012.
Yung S.S.Y. and Chan D.T.M., Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan, Journal of Biomedicine and Biotechnology. 2011.


Researcher : Zhang D
List of Research Outputs

Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.


Researcher : Zhang J
List of Research Outputs

Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Zhang J
List of Research Outputs

Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Zhang Q
List of Research Outputs

Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Binding of serum IgG to human mesangial cells and its correlation with disease activity in patients with lupus nephritis, The ACR/ARHP Annual Scientific Meeting, Chicago, USA. 2011.
Yap Y.H.D., Yung S.S.Y., Chan O.O.C., Zhang Q. and Chan D.T.M., Serum IgG binding to human mesangial cells in patients with lupus nephritis and its correlation with disease activity, Journal of the American Society of Nephrology. 2011.


Researcher : Zhang R
List of Research Outputs

Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38.


Researcher : Zhang X
List of Research Outputs

Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.


Researcher : Zhang Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Zhang Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Zhang Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Zhang Y
List of Research Outputs

Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Lee Y.K., Siu D.C.W., Zhang Y. and Tse H.F., Current Perspective of Stem Cells Therapy for Cardiac Regeneration. , Future Medicine-Therapy. 2011.
Lian Q., Zhang Y. and Tse H.F., 2012 10th Annual ISSCR Travel Grant Award. , International Society of Stem Cell Research(ISSCR). Yokohama, Japan, 13rd-16th, June, 2012." HUMAN IPSC-DERIVED MESENCHYMAL STEM CELLS MODULATE MYOCARDIAL REGENERATION THROUGH REDUCING OXIDATIVE STRESS AND RESTORING CARDIAC PROGENITOR CELLS IN ANTHRACYCLINE CARDIOMYOPATHY”. 2012.
Liao S., Tse H.F., Chan Y.C., Yip M.C.P., Zhang Y., Liu Y. and Li R.A., Over-expression of Kir2.1 Channel in Embryonic Stem Cell-Derived Cardiomyocytes Attenuates Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Heart Rhythm (Provisionally accepted). 2012.
Liao S., Liu Y., Zhang Y., Yue W., Chan Y.C., Li R.A. and Tse H.F., Over-expression of Kir2.1 channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction., Scientific Sessions 2011 (Orlando, FL, 2011), American Heart Association. 2011.
Liu Y., Yue W., Liao S., Zhang Y., Au K.W., Siu D.C.W. and Tse H.F., Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure, J Cardiovasc Electrophysiol. 2011, 23(5): 534-40.
Zhang D., Zhang Y., Sun H., Lau C.P. and Li G.R., Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. , Br J Pharmacol. 2011, 164(5): 1469-78.
Zhang X., Zhang Y., Sun H., Jin M.W. and Li G.R., Functional ion channels and cell proliferation in 3T3-L1 preadipocytes, J Cell Physiol. 2012, 227(5): 1972-1979.
Zhang Y., Tse H.F., Lau C.P. and Li G.R., BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells, 17th Medical Research Conference, Department of Medicine, HKU. 2012, 18(1): 63.
Zhang Y., Lam F.R.A.N.C.I.S. .F.U., Lee C.N., Tse H.F. and Lian Q., Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Are Superior To Adult Bone Marrow-derived Mesenchymal Stem Cells In The Treatment Of Limb Ischemia , 16th World Congress On Heart Disease Annual Scientific Sessions .23-27,july 2011, Vancouver, Canada. 2011.
Zhang Y., Wu W., Sun H., Deng X.L., Cheng L.C., Li X., Tse H.F., Lau C.P. and Li G.R., Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases, Cardiovasc Res.. 2012, 93(3): 424-33.
Zhang Y., Sun H. and Li G.R., Roles of functional ion channels in human cardiac c-kit+ progenitor cells, Kong - Taiwan Physiology Symposium, June. 2012, 52.
Zhang Y., Sun H., Wu H. and Li G.R., Trpc1 channels mediate the nonselective cation current and store-operated calcium channels in human atrial myocytes , Biophysical Journal/56th Annual Meeting of Biophysical Society, San Diego, California, USA. Feb 25-29. 2012, 2719-pos: 156.
Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305.


Researcher : Zheng C
List of Research Outputs

Lam S.K., Zheng C. and Ho J.C.M., Antiproliferative Effect of Arsenic Trioxide in Non-Small Cell Lung Carcinoma (NSCLC). 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S932 (P2.022).
Zheng C., Lam S.K. and Ho J.C.M., In-vitro Study of Arsenic Trioxide and Chemotherapeutic Agents in Small Cell Lung Carcinoma. 14th World Conference on Lung Cancer, Amsterdam, 3-7 July, Journal of Thoracic Oncology. 2011, Suppl 2; 6(6): S933 (P2.023).


Researcher : Zhou L
List of Research Outputs

Liu H., Ho W.L., Ho W.M., Ramsden D.B., Zhou L. and Ho S.L., Understanding Molecular Mechanisms Underlying Leucine-Rich Repeat Kinase 2 (Lrrk2)-Related Parkinson's Disease, XIX International Congress of Parkinson's disease and Related Disorders. Shanghai, China, Dec. 11-14, 2011. Parkinsonism & Related Disorders. 2012, 18 (Suppl 2): S180-S181.
Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.


Researcher : Zhou P
List of Research Outputs

Xiang Y., Zhou P., Li X., Huang G., Liu Z., Xu A., Leslie R.D. and Zhou Z., Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China, Diabetes Care. 2011, 34(7): 1639-41.


Researcher : Zou B
List of Research Outputs

Tse M.K., Tse M.K., Hui S.K., Yang Y.H., Yin S.T., Hu H.Y., Zou B., Wong B.C.Y., Sze K.H. and Sze K.H., Structural analysis of the UBA domain of x-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association, PLoS one. 2011, 6: e28511 (1-14).


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