DEPT OF PHYSIOLOGY
| Researcher : Ballard HJ |
| Project Title: | Interaction between K-ATP channel and CFTR in ATP efflux from muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Completion Date: | 09/2011 |
| Project Title: | Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in exercise-induced ATP release |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Completion Date: | 01/2013 |
| Project Title: | Involvement of chloride channels in ATP release from skeletal muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Researcher : Botelho FP |
| List of Research Outputs |
| Botelho F.P., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) regulates the acquisition of vestibular-mediated spatial orientation in rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 43. [HK. June 14-15, 2012]. 2012. |
| Botelho F.P., Lai C.H. and Chan Y.S., The regulatory role of brain-derived neurotrophic factor on the development of vestibular-related spatial orientation in rats, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 68 [HK March 3-4, 2012]. 2012. |
| Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Role of endocannabinoid and GABAA receptor in modulating synaptic plasticity in the vestibular nucleus of postnatal rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Researcher : Bourreau JP |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Endothelim-dependent hyperpolarization and relaxation of vascular smooth muscle: influence of the mode of excitation-coupling of vasoconstrictors |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Switch in G-protein coupling. Role of intracellular cAMP |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Researcher : Cai S |
| List of Research Outputs |
| Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Characterization of human bone marrow stromal cells following differentiation into Schwann cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 69. 2012. |
| Cai S., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration., CNS Neurol Disord Drug Targets. 2011, 11: 500-508. |
| Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Stable derivation of Schwann cells from human bone marrow stromal cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 57. 2012. |
| Cai S., Pan Y., Han B., Sun T.Z., Sheng Z.Y. and Fu X.B., Transplantation of human bone marrow-derived mesenchymal stem cells transfected with ectodysplasin for regeneration of sweat glands , Chin Med J . 2011, 124: 2260-2268. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Determinants of developmental plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Brain-derived neurotrophic factor regulates plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | 8th IBRO World Congress Acquisition of glutamate receptors in central vestibular synapses is crucial for developmental recognition of spatial orientation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| List of Research Outputs |
| Botelho F.P., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) regulates the acquisition of vestibular-mediated spatial orientation in rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 43. [HK. June 14-15, 2012]. 2012. |
| Botelho F.P., Lai C.H. and Chan Y.S., The regulatory role of brain-derived neurotrophic factor on the development of vestibular-related spatial orientation in rats, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 68 [HK March 3-4, 2012]. 2012. |
| Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Characterization of human bone marrow stromal cells following differentiation into Schwann cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 69. 2012. |
| Cai S., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration., CNS Neurol Disord Drug Targets. 2011, 11: 500-508. |
| Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Stable derivation of Schwann cells from human bone marrow stromal cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 57. 2012. |
| Chan Y.S., Ma C.W., Ng K.P. and Shum D.K.Y., Plasticity of neural correlates for spatial navigation, Abstracts of 2011 Neuroscience Symposium p. 16. [Kuala Lumpur, Malaysia. December 12-13, 2011]. 2011. |
| Chan Y.S., Lai S.K., Ma C.W., Hu H., Wong T.P. and Shum D.K.Y., The engagement of glutamate and GABA receptors in mediating spatial recognition behavior, Proc. 7th Congress of the Federation of Asian and Oceanian Physiological Societies p.35 [Taipei, Taiwan September 12-15, 2011]. 2011. |
| Chen W., Ma C.W., Lai C.H. and Chan Y.S., Neonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011. |
| Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition. 2012. |
| Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Lee T.M.C. and Cheung R.T.F., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development, and Cognition B. Aging, Neuropsychology and Cognition[Epub ahead of print]. 2012. |
| Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Chan Y.S., Mak H.K.F., Zhang J.X., Fung G. and Cheung C., Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer’s Disease , Journal of Alzheimer's Disease. 2011, 26: 47-58. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of synaptic transmission in medial vestibular nucleus, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of transmitter release in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society 68 Hong Kong: 57. 2012. |
| Kwok J.C., Yuen Y.L., Lau W.K., Zhang F.X., Fawcett J.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons, Neural Development 7: art. 6. 2012. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Activity assays of Chondroitinase ABCI immobilized on chitosan beads, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization Of Chondroitinase ABCI On Chitosan Beads To Improve Axonal Regrowth In Cspg-enriched Astrocyte Culture, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P62. 2012. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABCI on chitosan beads to improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Involvement of proheparanase and peri-synaptic heparan sulfate proteoglycan in synaptic plasticity to regulate AMPA-Type glutamate receptor trafficking, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase-mediated AMPA-type glutamate receptor regulation in synaptic plasticity, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012. |
| Leung T.C., Lui C.N., Chen L., Yung W.H., Chan Y.S. and Yung K.K., Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats, ACS Chemical Neuroscience. 2012, 3: 22-30. |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Li C., Lai C.H. and Chan Y.S., Spatial coding property of dorsomedial cellcolumn neurons in the vestibule-olivary pathway, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 86. 2012. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Involvement of perineuronal nets in developmental plasticity of the central vestibular system, Abstracts of 7th Int’l Symp. on Healthy Aging: 60. 2012. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Roles of perineuronal matrix in developmental plasticity of the central vestibular system, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012. |
| Ng O.T., Chen L., Chan Y.S. and Yung K.K., Small Interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase., Neurosignals[Epub ahead of print] . 2012. |
| Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Role of endocannabinoid and GABAA receptor in modulating synaptic plasticity in the vestibular nucleus of postnatal rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Leung H.Y. and Chan Y.S., Roles of notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells, Proc. 8th IBRO World Congress of Neuroscience: B077 [Florence Italy July 14-18, 2011] . 2011. |
| Sun W., Tie X., Chan Y.S. and Jiang B., Endocannabinoid receptor-dependent development of inhibitory synapses in layer 2/3 and layer 5 but not in layer 4 of mouse visual cortex, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Mechanism behind the fate commitment of bone marrow-derived schwann cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injury , Neuroscience 2011, 64.09/GG26 . 2011. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Factors Underlying Improved Efficacy Of Chondroitin Sulphate Lyases In Overcoming Chondroitin Sulphate Barriers For Nerve Repair And Regeneration, Seventh International Symposium on Healthy Aging, P5. 2012. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., The Mechanisms of Chondroitin Sulphate Lyases Treatment in Promotion of Axonal Growth, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P57. 2012. |
| Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for myelination therapy, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong: 72. 2012. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Generation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 65.. 2012. |
| Tung W.T., Chan Y.S. and Shum D.K.Y., ALIGNED CHITOSAN NANO-FIBERS FOR NERVE REGENERATION, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of Chitosan Fibers for Nerve Regeneration, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P63. 2012. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of chitosan fibers for nerve regeneration, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012. |
| Wu G.Y., Han X.H., Zhuang Q.X., Zhang J., Yung W.H., Chan Y.S., Zhu J.N. and Wang J.J., Excitatory effect of histamine on rat spinal motoneurons by activation of both H(1) and H(2) receptors in vitro., J. Neuroscience Research. 2012, 90: 132-142. |
| Researcher : Chen L |
| List of Research Outputs |
| Leung T.C., Lui C.N., Chen L., Yung W.H., Chan Y.S. and Yung K.K., Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats, ACS Chemical Neuroscience. 2012, 3: 22-30. |
| Ng O.T., Chen L., Chan Y.S. and Yung K.K., Small Interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase., Neurosignals[Epub ahead of print] . 2012. |
| Researcher : Chen W |
| List of Research Outputs |
| Chen W., Ma C.W., Lai C.H. and Chan Y.S., Neonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Researcher : Cheung KH |
| Project Title: | Presenilin Regulates Capactitative Calcium Entry – Implications for Alzheimer’s Disease Pathogenesis |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2011 |
| Project Title: | Molecular Mechanism of Capacitative Calcium Entry Deficits in Presenilin Mutations and Its Role in Alzheimers Disease Pathogenesis |
| Investigator(s): | Cheung KH, Chan YS, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | PS-TPC2 interaction: Mechanisms for autophay pathology in AD |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Bozym R.A., Patel K., White C., Cheung K.H., Bergelson J.M., Morosky S.A. and Coyne C.B., Calcium Signals and Calpain-dependent Necrosis Are Essential For Release Of Coxsackievirus B From Polarized Intestinal Epithelial Cells, Molecular Biology of The Cell. 2011, 22: 3010-3021. |
| Cheung K.H., Calcium Dysregulations and Alzheimer's Disease Pathogenesis, Frontiers in Biomedical Research, HKU 2011. 2011. |
| Cheung K.H., Calcium Dysregulations and Autophagy Impairment in Familial Alzheimer's Disease, Hong Kong-Taiwan Physiology Symposium 2012. 2012. |
| Cheung K.H., Tong C.K.B. and Foskett J.K., Patch-clamp Study Of Single Ryanodine Receptor Channels In The Outer Nuclear Membrane , Hong Kong-Taiwan Physiology Symposium 2012. |
| Kopil C.M., Vais H., Cheung K.H., Siebert A.P., Mak D.D., Foskett J.K. and Neumar R.W., Calpain-cleaved Type 1 Inositol 1,4,5-trisphosphate Receptor (InsP3R1) Has InsP3-independent Gating and Disrupts Intracellular Ca2+ Homeostasis., Journal of Biological Chemistry. 2011, 286: 35998-36010. |
| Lam C.S., Tipoe G.L., Chang R.C.C., Cheung K.H. and Fung M.L., Protective effect of Lycium barbarum polysaccharides against rat hippocampal injury induced by chronic intermittent hypoxia, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P31, 3/2012. |
| Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism Of Capacitative Calcium Entry Deficits In Familial Alzheimer’s Disease , Hong Kong-Taiwan Physiology Symposium 2012 . 2012. |
| Researcher : Chung SSM |
| List of Research Outputs |
| Cheung S.S.F., Leung J.W.C., Lam A.K.M., Lam K.S.L., Chung S.S.M., Lo A.C.Y. and Chung S.K., Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina, PLoS One . 2011, 6(10: e26184. |
| Hung K.L., Lai K.W., Lo A.C.Y., Lamb B.T., Chan K.C., Wu E.X., Cheung C.W., Chung S.S.M. and Chung S.K., Selective astrocytic ET-1 over-expression exacerbates cognitive deficit and cerebrovascular amyloid accumulation in animal models of stroke and Alzheimer's disease, The Twelfth Conference on Endothelin, 11-14 Sept 2011, Cambridge, UK. 2011. |
| Mak M.C., Lam K.M., Chan P.K., Lau J.Y.B., Tang W.H., Yeung P.K.K., Ko B.C.B., Chung S.S.M. and Chung S.K., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function, PLoS ONE. 2011, 6(7): e19186. |
| Researcher : Fung ML |
| Project Title: | Molecular basis for the inhibition of large conductance calcium-activated potassium channel by chronic intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2012 |
| Project Title: | Pathophysiological roles of pro-inflammatory cytokines in the carotid body in intermittent hypoxia |
| Investigator(s): | Fung ML, Tipoe GL |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Oxidative stress mediates endothelial dysfunction, vascular inflammation and systemic hypertension in rats with chronic intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | The XVIIIth Meeting of the International Society for Arterial Chemoreception (ISAC) Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Pathophysiological mechanisms of myocardial dysfunction in intermittent hypoxia: roles of oxidative stress in impaired calcium homeostasis |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Fung M.L., Carotid body function in health and disease, Fudan Univ J Med Sci 39(1) : 5-11, 2012. 2012. |
| Lam C.S., Tipoe G.L. and Fung M.L., Neuroprotective effects of Lycium barbarum polysaccharides against rat hippocampal apoptosis induced by chronic intermittent hypoxia, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Lam C.S., Tipoe G.L., Chang R.C.C., Cheung K.H. and Fung M.L., Protective effect of Lycium barbarum polysaccharides against rat hippocampal injury induced by chronic intermittent hypoxia, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P31, 3/2012. |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Lam S.S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia., XVIIIth ISAC (International Society for Arterial Chemoreception) Conference. 2011. |
| Lam S.Y.S., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, The 18th International Society for Arterial Chemoreception Meeting, Hamilton, Canada, P4.4, 7/2011. |
| Li J., Li F.Y.L., Xu A., Cheng B., Tsao G.S.W., Fung M.L. and Leung W.K., Lipopolysaccharide and Hypoxia Induce HIF-1 Activation in Human Gingival Fibroblasts, Journal of Periodontology. 2011, 1-8. |
| Li J.P., Fung M.L. and Leung W.K., Lipopolysaccharide and Hypoxia Modulate Collagen Metabolism in Human Gingival Fibroblasts, 25th International Association for Dental Research-SEA Division Annual Scientific Meeting, Singapore 10/2011. |
| Liu Y., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Blockade of renin-angiotensin system attenuates local inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P19, 3/2012. |
| Liu Y. and Fung M.L., Involvement of NADPH oxidase and renin-angiotensin system in tissue inflammation of the rat adrenal medulla during intermittent hypoxia, The 15th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP04, 9/2011. |
| Liu Y., Tipoe G.L., Xiao J., Huang Y. and Fung M.L., NADPH oxidase upregulated by AT1 receptor mediates chronic intermittent hypoxia-induced oxidative stress and inflammation in rat adrenal medulla, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Liu Y. and Fung M.L., NADPH oxidase upregulated by renin-angiotensin system mediates the oxidative stress and inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, 16th Research Postgraduate Symposium, HKU, P1.12, 12/2011. |
| Liu Y. and Fung M.L., Role of NADPH oxidase and renin-angiotensin system in intermittent hypoxia-induced inflammation in rat adrenal medulla, The 18th Annual Meeting of the Society for (Free Radical Biology and Medicine 2011, Atlanta USA 11/2011. (Free Radical Biology and Medicine 51:S106 Suppl. 1, 2011). 2011. |
| Ng K.M., Chan Y.C., Lee Y.K., Lai W.W., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level, Cellular Reprogramming. 2011, 13(6): 527-37. |
| Pan J., Tipoe G.L., Xiao J., Liu Y. and Fung M.L., Blockade of AT1 receptor mitigates hepatic oxidative stress and inflammation induced by intermittent hypoxia in rats, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Anti-apoptotic effect of garlic derived S-allylmercaptocysteine (SAMC) in a non-alcoholic fatty liver disease rat model through p53-dependent pathways, The Seventh International Symposium on Healthy Aging . 2012. |
| Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2012, DOI 10.1007/s00394-012-0301-0. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective Effects of Wolfberry (Lycium Bar-Barum; LBP) in Carbon-Tetrachloride induced Acute Liver injury in mice through reduction in Oxidative Stress, Necroinflammation and Nuclear Transcription Factor Activity, Hepatology. 2011, 54, No. 4 (Suppl.): 514A. |
| Xiao J., Ching Y.P., Liong E.C., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Protective effects of Wolfberry (Lycium barbarum; LBP) in carbon-tetrachloride induced acute liver injury in mice through reduction in oxidative stress, necroinflammation and nuclear transcription factor activity, 62ndAnnual Meeting of the American Association for the Study of Liver Diseases 2011, San Francisco USA 11/2011. (Hepatology 54: 514A, Suppl. 1, 2011). 2011. |
| Xiao J., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Reduction in hepatic apoptosis modulated by garlic derived S-allylmercaptocysteine (SAMC) in non-alcoholic fatty liver disease rat model through p53-dependent pathways, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Xiao J., Liong E.C., Ling M.T., Ching Y.P., Fung M.L. and Tipoe G.L., S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa b-dependent pathways in mice, European Journal of Nutrition. 2012, 51(3): 323:333. |
| Xiao J., Ching Y.P., Fung M.L. and Tipoe G.L., The protective mechanisms of Lycium Barbarum polysaccharides in non-alcoholic fatty liver disease, 16th Research Postgraduate Symposium, HKU, P2.24, 12/2011. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation, Journal of Ethnopharmacology. 2012, 139: 462-470. |
| Researcher : Graeff RM |
| Project Title: | Mechanism of the novel Ca2+-signaling pathway mediated by NAADP. |
| Investigator(s): | Graeff RM |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2011 |
| List of Research Outputs |
| Kotaka M., Graeff R.M., Zhang L., Lee H.C. and Hao Q., Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase, XXII International Congress and General Assembly of the IUCr . 2011. |
| Kotaka M., Graeff R.M., Chen Z., Zhang L.H., Lee H.C. and Hao Q., Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase, J. Mol. Bio.. 2012, 415: 514-526. |
| Zhao Y., Graeff R.M. and Lee H.C., Roles of cADPR and NAADP in pancreatic cells, Acta Biochim Biophys Sin (Shanghai). 2012. |
| Researcher : Han L |
| List of Research Outputs |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of synaptic transmission in medial vestibular nucleus, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of transmitter release in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society 68 Hong Kong: 57. 2012. |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Researcher : Hao B |
| List of Research Outputs |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Researcher : Hao Q |
| Project Title: | A new method for macromolecular structure determination: envelope-based phasing |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2009 |
| Project Title: | Structural biology of sirtuins |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Structure and Function of the TRPM2 channel |
| Investigator(s): | Hao Q, Kotaka M, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Structural Basis of an Inflammatory Disease caused by IL-10R1 mutations |
| Investigator(s): | Hao Q, Lau YL |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2012 |
| List of Research Outputs |
| Du J.T., Zhou Y.Y., Su X.Y., Yu J.J., Khan S., Jiang H., Kim J., Woo J., Kim J.H., Chio B.H., He B., Zhang S., Cerione R.A., Auwerx J., Hao Q. and Lin H.N., Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase., Science. 2011, 334: 806-809. |
| Hao Q., Synchrotron-base Structural Biology: Challenges and Opportunities (2), SSRF Phase II Beamline Planning Meeting,. 2011. |
| Kotaka M., Graeff R.M., Zhang L., Lee H.C. and Hao Q., Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase, XXII International Congress and General Assembly of the IUCr . 2011. |
| Kotaka M., Graeff R.M., Chen Z., Zhang L.H., Lee H.C. and Hao Q., Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase, J. Mol. Bio.. 2012, 415: 514-526. |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Law W.L., Lescar J., Hao Q. and Kotaka M., Expression, purification, crystallization and preliminary X-ray analysis of Plasmodium falciparum GTP:AMP phosphotransferase, Acta Crystallographica Section F Structural Biology and Crystallization Communications. 2012, F68: 671–674. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease (CaBP17) July 16-21, 2011 Beijing, China. 2011. |
| Zhou W.Q., Yan H., Fan X.D. and Hao Q., Prediction of protein-protein interactions using alpha shape modeling, 2011 INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MODELS FOR LIFE SCIENCES (CMLS-11). 2011, 1371: 244-252. |
| Zhu A.Y., Zhou Y.Y., Deitsch K.W., Hao Q. and Lin H.N., Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine, ACS Chemical Biology. 2012, 7: 155-159. |
| Researcher : Hu H |
| List of Research Outputs |
| Chan Y.S., Lai S.K., Ma C.W., Hu H., Wong T.P. and Shum D.K.Y., The engagement of glutamate and GABA receptors in mediating spatial recognition behavior, Proc. 7th Congress of the Federation of Asian and Oceanian Physiological Societies p.35 [Taipei, Taiwan September 12-15, 2011]. 2011. |
| Researcher : Jiang B |
| List of Research Outputs |
| Sun W., Tie X., Chan Y.S. and Jiang B., Endocannabinoid receptor-dependent development of inhibitory synapses in layer 2/3 and layer 5 but not in layer 4 of mouse visual cortex, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Researcher : Kotaka M |
| Project Title: | Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on interaction of influenza A NS1 protein with TRIM25, an E3 ubiquitin ligase essential for RIG-I activation |
| Investigator(s): | Kotaka M, Hui PY |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2010 |
| Completion Date: | 12/2011 |
| Project Title: | Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on influenza A viral RNA recognition and discrimination by RIG-I |
| Investigator(s): | Kotaka M, Hui PY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Structural determination of Crimean-Congo Haemorraghic Fever viral nucleocapsid protein |
| Investigator(s): | Kotaka M |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 02/2012 |
| Project Title: | International Union of Crystallography 2011 XXII International Congress and General Assembly Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase |
| Investigator(s): | Kotaka M |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2011 |
| Completion Date: | 08/2011 |
| Project Title: | Structural determination of potential anti-malarial drug targets |
| Investigator(s): | Kotaka M |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Dutta S., Gupta G., Choi Y.W., Kotaka M., Fielding B.C., Song J. and Tan Y.J., The variable N terminal region of DDX5 contains structural elements and autoinhibits its interaction with NS5B of hepatitis C virus, Biochemical Journal. 2012. |
| Kotaka M., Graeff R.M., Zhang L., Lee H.C. and Hao Q., Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase, XXII International Congress and General Assembly of the IUCr . 2011. |
| Kotaka M., Graeff R.M., Chen Z., Zhang L.H., Lee H.C. and Hao Q., Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase, J. Mol. Bio.. 2012, 415: 514-526. |
| Law W.L., Lescar J., Hao Q. and Kotaka M., Expression, purification, crystallization and preliminary X-ray analysis of Plasmodium falciparum GTP:AMP phosphotransferase, Acta Crystallographica Section F Structural Biology and Crystallization Communications. 2012, F68: 671–674. |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011. |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011. |
| Researcher : Kwong KY |
| List of Research Outputs |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Researcher : Lai CH |
| List of Research Outputs |
| Botelho F.P., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) regulates the acquisition of vestibular-mediated spatial orientation in rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 43. [HK. June 14-15, 2012]. 2012. |
| Botelho F.P., Lai C.H. and Chan Y.S., The regulatory role of brain-derived neurotrophic factor on the development of vestibular-related spatial orientation in rats, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 68 [HK March 3-4, 2012]. 2012. |
| Chen W., Ma C.W., Lai C.H. and Chan Y.S., Neonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of synaptic transmission in medial vestibular nucleus, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of transmitter release in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society 68 Hong Kong: 57. 2012. |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Li C., Lai C.H. and Chan Y.S., Spatial coding property of dorsomedial cellcolumn neurons in the vestibule-olivary pathway, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 86. 2012. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Involvement of perineuronal nets in developmental plasticity of the central vestibular system, Abstracts of 7th Int’l Symp. on Healthy Aging: 60. 2012. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Roles of perineuronal matrix in developmental plasticity of the central vestibular system, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of proheparanase in synaptic plasticity at the hippocampus, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18, B199. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Shum D.K.Y. and Chan Y.S., The role of proheparanase in synaptic plasticity at the hippocampus, 9th Biennial Conference of the Chinese Neuroscience Society and The 5th Member Congress, Zhengzhou, China. Jul 29 - Aug 1, P-110. 2011. |
| Researcher : Lai SK |
| List of Research Outputs |
| Chan Y.S., Lai S.K., Ma C.W., Wong T.P. and Shum D.K.Y., Acquisition of glutamate receptors in central vestibular synapses is crucial for developmental recognition of spatial orientation, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18. S16.3. 2011. |
| Chan Y.S., Lai S.K., Ma C.W., Hu H., Wong T.P. and Shum D.K.Y., The engagement of glutamate and GABA receptors in mediating spatial recognition behavior, Proc. 7th Congress of the Federation of Asian and Oceanian Physiological Societies p.35 [Taipei, Taiwan September 12-15, 2011]. 2011. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of synaptic transmission in medial vestibular nucleus, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 71. 2012. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT-triggered facilitation of transmitter release in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society 68 Hong Kong: 57. 2012. |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Researcher : Lam CS |
| List of Research Outputs |
| Lam C.S., Tipoe G.L. and Fung M.L., Neuroprotective effects of Lycium barbarum polysaccharides against rat hippocampal apoptosis induced by chronic intermittent hypoxia, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Lam C.S., Tipoe G.L., Chang R.C.C., Cheung K.H. and Fung M.L., Protective effect of Lycium barbarum polysaccharides against rat hippocampal injury induced by chronic intermittent hypoxia, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P31, 3/2012. |
| Researcher : Lam MC |
| List of Research Outputs |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease (CaBP17) July 16-21, 2011 Beijing, China. 2011. |
| Researcher : Lam SSY |
| Project Title: | An investigation into the synergistic effect of prenatal infection and hypoxia on brain and behavioural abnormalities relevant to Schizophrenia and related neurodevelopmental disorders |
| Investigator(s): | Lam SSY, McAlonan GM, Chua SE |
| Department: | Psychiatry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 08/2012 |
| Project Title: | 3rd Biennial Schizophrenia International Research Conference Oxygen restriction of neonate rats elevates HIF-1α, IL-6, NF-kb and capase-3 protein levels: possible relationship to neurodevelopmental disorders |
| Investigator(s): | Lam SSY |
| Department: | Psychiatry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2012 |
| Completion Date: | 04/2012 |
| List of Research Outputs |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Lam S.S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia., XVIIIth ISAC (International Society for Arterial Chemoreception) Conference. 2011. |
| Researcher : Lam SYS |
| List of Research Outputs |
| Lam S.Y.S., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, The 18th International Society for Arterial Chemoreception Meeting, Hamilton, Canada, P4.4, 7/2011. |
| Researcher : Lau CF |
| List of Research Outputs |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Researcher : Law WL |
| List of Research Outputs |
| Law W.L., Lescar J., Hao Q. and Kotaka M., Expression, purification, crystallization and preliminary X-ray analysis of Plasmodium falciparum GTP:AMP phosphotransferase, Acta Crystallographica Section F Structural Biology and Crystallization Communications. 2012, F68: 671–674. |
| Researcher : Lee HC |
| Project Title: | Chemical synthesis and biological characterizations of antagonists of a novel calcium signaling enzyme - CD38 |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2009 |
| Completion Date: | 12/2011 |
| Project Title: | Structure and Function of the ADP-ribosyl Cyclases. |
| Investigator(s): | Lee HC, Hao Q, Li GR |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Regulation of the Calcium Messenger Cyclic ADP-ribose. |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | FASEB Summer Research Conferences 2011 on NAD Metabolism and Signaling Cyclic ADP-ribose and NAADP. Unraveling the calcium signaling functions of NAD |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2011 |
| Completion Date: | 09/2011 |
| Project Title: | Engineering CD38 for Calcium Signaling |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| List of Research Outputs |
| Kotaka M., Graeff R.M., Zhang L., Lee H.C. and Hao Q., Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase, XXII International Congress and General Assembly of the IUCr . 2011. |
| Kotaka M., Graeff R.M., Chen Z., Zhang L.H., Lee H.C. and Hao Q., Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase, J. Mol. Bio.. 2012, 415: 514-526. |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease (CaBP17) July 16-21, 2011 Beijing, China. 2011. |
| Zhao Y., Graeff R.M. and Lee H.C., Roles of cADPR and NAADP in pancreatic cells, Acta Biochim Biophys Sin (Shanghai). 2012. |
| Researcher : Leung CFP |
| Project Title: | Regulation of CD38 in abscisic acid-activated human monocytes. |
| Investigator(s): | Leung CFP, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| List of Research Outputs |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Researcher : Li C |
| List of Research Outputs |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Li C., Lai C.H. and Chan Y.S., Spatial coding property of dorsomedial cellcolumn neurons in the vestibule-olivary pathway, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 86. 2012. |
| Researcher : Li GR |
| Project Title: | Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
| Investigator(s): | Li GR, Lau CP, Chiu SW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2001 |
| Project Title: | Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts |
| Investigator(s): | Li GR, Lau CP, Lee HC, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives |
| Investigator(s): | Li GR, Vanhoutte PMGR |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 03/2010 |
| Completion Date: | 08/2011 |
| Project Title: | Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation |
| Investigator(s): | Li GR |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2011 |
| Project Title: | 56th Annual Meeting of Biophysical Society TRPC1 CHANNELS MEDIATE THE NONSELECTIVE CATION CURRENT AND STORE-OPERATED CALCIUM CHANNELS IN HUMAN ATRIAL MYOCYTES |
| Investigator(s): | Li GR |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2012 |
| Completion Date: | 02/2012 |
| Project Title: | Demonstration of TRPM channels in human cardiac atrial myocytes |
| Investigator(s): | Li GR, Li X |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2012 |
| List of Research Outputs |
| Loo T.Y., Wang M., Jin L., Cheung M.N.B. and Li G.R., Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis, Archives of Oral Biology. 2011, 56: 1081-1090. |
| Researcher : Li L |
| List of Research Outputs |
| Li L., O W.S. and Tang F., Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1, Reproductive Biology and Endocrinology. 2011, 9: 111-123. |
| Li L., Tang F. and O W.S., Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size, Theriogenology. 2012, 77: 1846-1853. |
| Researcher : Li S |
| List of Research Outputs |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Researcher : Liu VWS |
| List of Research Outputs |
| Shiu S.Y.W., Leung W.Y.G., Tam C.W., Liu V.W.S. and Yao K.M., Melatonin MT(1) receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibtion of constitutively active nuclear factor kappa B (NF-kB): potential implications on prostate cancer chemoprevention and therapy, J Pineal Res. 2012, 54 (Jan 2013): 69-79. |
| Researcher : Liu Y |
| List of Research Outputs |
| Lam S.S.Y., Liu Y., Ng K.M., Lau C.F., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways, Histochem Cell Biol.. 2012, 137(3): 303-17. |
| Lam S.S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia., XVIIIth ISAC (International Society for Arterial Chemoreception) Conference. 2011. |
| Lam S.Y.S., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, The 18th International Society for Arterial Chemoreception Meeting, Hamilton, Canada, P4.4, 7/2011. |
| Liu Y., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Blockade of renin-angiotensin system attenuates local inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, The Seventh International Symposium on Healthy Aging – Live Well Age Well, P19, 3/2012. |
| Liu Y. and Fung M.L., Involvement of NADPH oxidase and renin-angiotensin system in tissue inflammation of the rat adrenal medulla during intermittent hypoxia, The 15th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP04, 9/2011. |
| Liu Y., Tipoe G.L., Xiao J., Huang Y. and Fung M.L., NADPH oxidase upregulated by AT1 receptor mediates chronic intermittent hypoxia-induced oxidative stress and inflammation in rat adrenal medulla, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Liu Y. and Fung M.L., NADPH oxidase upregulated by renin-angiotensin system mediates the oxidative stress and inflammation induced by chronic intermittent hypoxia in rat adrenal medulla, 16th Research Postgraduate Symposium, HKU, P1.12, 12/2011. |
| Liu Y. and Fung M.L., Role of NADPH oxidase and renin-angiotensin system in intermittent hypoxia-induced inflammation in rat adrenal medulla, The 18th Annual Meeting of the Society for (Free Radical Biology and Medicine 2011, Atlanta USA 11/2011. (Free Radical Biology and Medicine 51:S106 Suppl. 1, 2011). 2011. |
| Pan J., Tipoe G.L., Xiao J., Liu Y. and Fung M.L., Blockade of AT1 receptor mitigates hepatic oxidative stress and inflammation induced by intermittent hypoxia in rats, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Researcher : Lu Y |
| List of Research Outputs |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Researcher : Lung MAKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | The therapeutic value of Prostaglandin E2 on nasal congestion in acute experimental rhinitis |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 11/2011 |
| Project Title: | Prostaglandin E receptors in the control of nasal patency. |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Researcher : Lung MKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | The therapeutic value of Prostaglandin E2 on nasal congestion in acute experimental rhinitis |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 11/2011 |
| Project Title: | Prostaglandin E receptors in the control of nasal patency. |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Researcher : Ma CW |
| List of Research Outputs |
| Chan Y.S., Ma C.W., Ng K.P. and Shum D.K.Y., Plasticity of neural correlates for spatial navigation, Abstracts of 2011 Neuroscience Symposium p. 16. [Kuala Lumpur, Malaysia. December 12-13, 2011]. 2011. |
| Chan Y.S., Lai S.K., Ma C.W., Hu H., Wong T.P. and Shum D.K.Y., The engagement of glutamate and GABA receptors in mediating spatial recognition behavior, Proc. 7th Congress of the Federation of Asian and Oceanian Physiological Societies p.35 [Taipei, Taiwan September 12-15, 2011]. 2011. |
| Chen W., Ma C.W., Lai C.H. and Chan Y.S., Neonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Involvement of proheparanase and peri-synaptic heparan sulfate proteoglycan in synaptic plasticity to regulate AMPA-Type glutamate receptor trafficking, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase-mediated AMPA-type glutamate receptor regulation in synaptic plasticity, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012. |
| Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Roles of perineuronal matrix in developmental plasticity of the central vestibular system, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012. |
| Researcher : Ng KP |
| List of Research Outputs |
| Chan Y.S., Ma C.W., Ng K.P. and Shum D.K.Y., Plasticity of neural correlates for spatial navigation, Abstracts of 2011 Neuroscience Symposium p. 16. [Kuala Lumpur, Malaysia. December 12-13, 2011]. 2011. |
| Researcher : Pan J |
| List of Research Outputs |
| Pan J., Tipoe G.L., Xiao J., Liu Y. and Fung M.L., Blockade of AT1 receptor mitigates hepatic oxidative stress and inflammation induced by intermittent hypoxia in rats, HK-Taiwan Physiology Symposium, CUHK 6/2012. |
| Researcher : Shi W |
| List of Research Outputs |
| Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Role of endocannabinoid and GABAA receptor in modulating synaptic plasticity in the vestibular nucleus of postnatal rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012. |
| Researcher : Shiu SYW |
| Project Title: | Growth-modulatory effects of the melatonin receptor agonist ramelteon on prostate epithelial cells |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2009 |
| Completion Date: | 11/2011 |
| Project Title: | Interactions between melatonin and NF-κB in the regulation of prostate cancer cell growth |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| List of Research Outputs |
| Chong T.Y.I., Chan C.Y., Lee C.Y.L., Shiu S.Y.W., Li J.Y.H. and Yao K.M., Establishing a Cell-based Platform to identify Molecules for Directing the Differentiation of Human Embryonic Stem Cells into Insulin-secreting β-like cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Shiu S.Y.W., Leung W.Y.G., Tam C.W., Liu V.W.S. and Yao K.M., Melatonin MT(1) receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibtion of constitutively active nuclear factor kappa B (NF-kB): potential implications on prostate cancer chemoprevention and therapy, J Pineal Res. 2012, 54 (Jan 2013): 69-79. |
| Tam C.W. and Shiu S.Y.W., Establishing evidence for management of prostate cancer: An investigation on the functional interactions between melatonin and androgen receptor signaling in human prostate epithelial cells, Fifth Pan-Pacific Nursing Conference and Seventh Nursing Symposium on Cancer Care, 22-24 September. 2011, G31. |
| Tam C.W. and Shiu S.Y.W., Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer, Journal of Pineal Research. 2011, 51: 297-312. |
| Researcher : Tai WYE |
| List of Research Outputs |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012. |
| Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Leung H.Y. and Chan Y.S., Roles of notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells, Proc. 8th IBRO World Congress of Neuroscience: B077 [Florence Italy July 14-18, 2011] . 2011. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Mechanism behind the fate commitment of bone marrow-derived schwann cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012. |
| Researcher : Tam CW |
| List of Research Outputs |
| Shiu S.Y.W., Leung W.Y.G., Tam C.W., Liu V.W.S. and Yao K.M., Melatonin MT(1) receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibtion of constitutively active nuclear factor kappa B (NF-kB): potential implications on prostate cancer chemoprevention and therapy, J Pineal Res. 2012, 54 (Jan 2013): 69-79. |
| Tam C.W. and Shiu S.Y.W., Establishing evidence for management of prostate cancer: An investigation on the functional interactions between melatonin and androgen receptor signaling in human prostate epithelial cells, Fifth Pan-Pacific Nursing Conference and Seventh Nursing Symposium on Cancer Care, 22-24 September. 2011, G31. |
| Tam C.W. and Shiu S.Y.W., Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer, Journal of Pineal Research. 2011, 51: 297-312. |
| Researcher : Tam KV |
| List of Research Outputs |
| Tam K.V., Lee T.O., Cheng C.H.K. and Chow B.K.C., The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation., Gen, Comp. Endocrinol.. 2011, 173(3). |
| Researcher : Tam KW |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABCI on chitosan beads to improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012. |
| Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of chitosan fibers for nerve regeneration, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012. |
| Researcher : Tang F |
| Project Title: | Adrenomedullin in the male sex acessory glands: gene expression, levels and receptor binding, functions and regulation of production in the prostate, seminal vesicle and coagulating gland. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2008 |
| Completion Date: | 02/2012 |
| Project Title: | Interaction of adrenomedullin and adipocytokines and adipokines in the soleus muscle and epididymal fat pad. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Completion Date: | 08/2011 |
| Project Title: | Intermedin (adrenomedullin 2) in the testis: gene expression, physiological actions and regulation of secretion. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| Project Title: | Effects of adrenomedullin on fluid secretion in the oviduct and the seminal vesicle. |
| Investigator(s): | Tang F, Cheung KH, Chen J, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Cheung B.M.Y. and Tang F., Adrenomedullin: Exciting New Horizons, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2012, 6 (1): 4-17. |
| Li L., O W.S. and Tang F., Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1, Reproductive Biology and Endocrinology. 2011, 9: 111-123. |
| Li L., Tang F. and O W.S., Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size, Theriogenology. 2012, 77: 1846-1853. |
| Liao S., Kong L.H.M., Tang F. and O W.S., Possible functions of adrenomedullin from the seminal fluid in the female reproductive tract of the rat, Informa Healthcare. 2012, 58: 306-312. |
| Liao S., Li R.H.W., Ho J.C.M., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy, Journal of Clinical Endocrinology and Metabolism . Journal of Clinical Endocrinolog and Metabolism, 2012, 97: 2105-2112. |
| O W.S., Liao S., Li R.H.W., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., The role of adrenomedullin in tubal ectopic pregnancy, World Congress on Reproductive Biology Abstracts, Cairns, Australia. 2011, 81 Abstract 124. |
| Wong P.F., O W.S. and Tang F., An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart, Endocrine. 2012, 41: 256-265. |
| Researcher : Ting KY |
| List of Research Outputs |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Researcher : Tong CKB |
| List of Research Outputs |
| Cheung K.H., Tong C.K.B. and Foskett J.K., Patch-clamp Study Of Single Ryanodine Receptor Channels In The Outer Nuclear Membrane , Hong Kong-Taiwan Physiology Symposium 2012. |
| Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism Of Capacitative Calcium Entry Deficits In Familial Alzheimer’s Disease , Hong Kong-Taiwan Physiology Symposium 2012 . 2012. |
| Researcher : Wang J |
| List of Research Outputs |
| Wang J., Lieu D.K., Karakikes I., Chen A., Turnbull I., Kong M.C.W., Hajjar R., Costa K., Khine M. and Li R.A., Engineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: An accurate arrhythmias model for cardiotoxicity screening., Days of Molecular Medicine, 2011. |
| Researcher : Wong PF |
| List of Research Outputs |
| Wong P.F., O W.S. and Tang F., An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart, Endocrine. 2012, 41: 256-265. |
| Researcher : Wong TM |
| Project Title: | First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2000 |
| Project Title: | XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+ |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2004 |
| Project Title: | CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| List of Research Outputs |
| Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305. |
| Researcher : Yeung WSB |
| Project Title: | Characterization of Stem/Progenitor Cells in Human Endometriosis |
| Investigator(s): | Yeung WSB, Chan RWS, Lee CKF, Luk JMC, Ng EHY |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Role of microRNA let-7 in implantation of mouse blastocysts |
| Investigator(s): | Yeung WSB, Lee CKF, Liu W, Pang RTK |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Control of human extravillous cytotrophoblast invasion by adrenomedullin |
| Investigator(s): | Yeung WSB, Chiu CN |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 02/2013 |
| Project Title: | World Congress on Reproductive Biology 2011 Glycodelin-C and the role of cumulus complex in natural sperm quality selection |
| Investigator(s): | Yeung WSB |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2011 |
| Completion Date: | 10/2011 |
| Project Title: | MicroRNA-135a induction transforms normal human papillomarvirus infected cervical cells into cells with cancer stem cell-like properties. |
| Investigator(s): | Yeung WSB, Pang RTK |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Liu W., Pang R.T.K., Cheong A.W.Y., Lee C.K.F. and Yeung W.S.B., Excellent Poster Presentation: Involvement of microRNA Lethal-7a in the Regulation of Embryo Implantation in Mice, 2nd SKLRB Symposia on “Frontiers in Reproductive Biology. 2012. |
| Researcher : Yu P |
| List of Research Outputs |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Researcher : Yue J |
| Project Title: | Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and RNAi screen |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2008 |
| Project Title: | Dissecting the mechanism and function of the CD38/cADPR/Ca2+ signaling in PC12 cell proliferation and differentiation |
| Investigator(s): | Yue J, Chan YS, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2009 |
| Completion Date: | 09/2011 |
| Project Title: | Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and RNAi screen |
| Investigator(s): | Yue J, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 12/2009 |
| Completion Date: | 11/2012 |
| Project Title: | Modulation of the neural lineage entry of mouse embryonic stem cells by the CD38/cADPR/Ca2+ signaling pathway |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Role of the CD38/cADPR/Ca2+ signaling pathway in cardiomyocyte differentiation of mouse embryonic stem cell |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2011 |
| Project Title: | The role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | 51st American Society for Cell Biology (ASCB) Annual Meeting Dichotomic role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2011 |
| Completion Date: | 12/2011 |
| Project Title: | Molecular mechanisms of self-renewal and neuronal differentiation of neural stem cells |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Li S., Hao B., Lu Y., Yu P., Lee H.C. and Yue J., Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), Plos One. 2012, 7: e31905. |
| Yue J., Dichotomic role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells, 51th The American Society for Cell Biology Annual Meeting, Denver CO, USA. 2011. |
| Zhou Y., Yu P., Jin H., Yang Z., Yue J., Zhang L. and Zhang L., Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications, Molecules. 2012, 17: 4343-56. |
| Researcher : Yuen YL |
| List of Research Outputs |
| Kwok J.C., Yuen Y.L., Lau W.K., Zhang F.X., Fawcett J.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons, Neural Development 7: art. 6. 2012. |
| Researcher : Zhang FX |
| List of Research Outputs |
| Kwok J.C., Yuen Y.L., Lau W.K., Zhang F.X., Fawcett J.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons, Neural Development 7: art. 6. 2012. |
| Researcher : Zhang H |
| Project Title: | Interaction studies of CD38 with CD4 and anti-CD38 antibodies |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Structural study of New Delhi metallo-beta-lactamase for rational inhibitor design |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2011 |
| Project Title: | Structural study of virulence factor from Aspergillus fumigatus |
| Investigator(s): | Zhang H |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Kwong K.Y., Chen Z., Zhang H., Leung C.F.P., Lam M.C., Ting K.Y., Zhang L.R., Hao Q., Zhang L.H. and Lee H.C., Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Biochemistry. 2012, 51: 555-564. |
| Ng A.K., Lam M.K., Zhang H., Liu J., Au S.W., Chan P.K., Wang J. and Shaw P.C., Structural basis for RNA-binding and homo-oligomer formation by influenza B virus nucleoprotein, J Virol. 2012. |
| Zhang H. and Wang J.H., Protein expression and purification of integrin I domains and IgSF ligands for crystallography, Methods Mol Biol. 2011, 757: 101-10. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease (CaBP17) July 16-21, 2011 Beijing, China. 2011. |
| Researcher : Zhao Y |
| Project Title: | Characteristics and potential regulatory mechanisms of a cytosolic CD38 |
| Investigator(s): | Zhao Y, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | the 2011 ASCB Annual Meeting Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose |
| Investigator(s): | Zhao Y |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2011 |
| Completion Date: | 12/2011 |
| List of Research Outputs |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease (CaBP17) July 16-21, 2011 Beijing, China. 2011. |
| Zhao Y., Graeff R.M. and Lee H.C., Roles of cADPR and NAADP in pancreatic cells, Acta Biochim Biophys Sin (Shanghai). 2012. |
| Researcher : Zhou Y |
| List of Research Outputs |
| Zhou Y., Wu H., Zhang Y., Sun H., Wong T.M. and Li G.R., Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane. , Toxicology. 2011, 290(2-3): 296-305. |