MEDICAL FACULTY
| Researcher : Altmeyer RM |
| List of Research Outputs |
| Chao B., Tong X.K., Tang W., Li D.W., He P.L., Garcia J.C., Gao A.H., Yang L., Li J., Nan F.J., Jacobs M., Altmeyer R.M., Zuo J.P. and Hu Y.H., Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives As a New Class of Potent Dengue Virus Inhibitors. , J Med Chem. . 2012, 12: 3135-43. |
| Jaume M.D.A., Yip M.S., Cheung C.Y., Leung H.L., Li P.H., Kien F.S., Dutry I.C.A., Callendret B., Escriou N., Altmeyer R.M., Nal-Rogier B.T.M., Daeron M., Bruzzone R. and Peiris J.S.M., Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent FcgR Pathway, Journal of Virology. 2011, 85. |
| Jaume M.D.A., Yip M.S., Cheung C.Y., Kien F.S., Li P.H., Dutry I.C.A., Bruzzone R., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Sars Cov Subunit Vaccine: Antibody-mediated Neutralisation And Enhancement., In: Jaume M, Yip MS, Kam YW, Cheung CY, Kien F, Roberts A, Li PH, Dutry I, Escriou N, Daeron M, Bruzzone R, Subbarao K, Peiris JS, Nal B, Altmeyer R, Hong Kong Med J.. Hong Kong, 2012, 18: Suppl 2:31-6. |
| Researcher : Boheler KR |
| List of Research Outputs |
| Fu J.D., Rushing S.N., Lieu D.K., Chan C.W.Y., Kong M.C.W., Geng L., Wilson K.D., Chiamvimonvat N., Boheler K.R. and Wu J.C., Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes, PLoS One. 2011, 6(11): e27417. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Determinants of developmental plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Brain-derived neurotrophic factor regulates plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | 8th IBRO World Congress Acquisition of glutamate receptors in central vestibular synapses is crucial for developmental recognition of spatial orientation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| List of Research Outputs |
| Chan Y.S., Lai S.K., Ma C.W., Wong T.P. and Shum D.K.Y., Acquisition of glutamate receptors in central vestibular synapses is crucial for developmental recognition of spatial orientation, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18. S16.3. 2011. |
| Cheah K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Mak A.C.Y., Chan Y.S., Lovell-Badge R., Chan W.Y. and Fritzsch B., Defects in cochlear structure and function in the Sox9Y440X campomelic dysplasia mouse model , Wellcome Trust scientific conferences : 8th Molecular Biology of Hearing and Deafness Conference. 2011. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Modulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Abstracts of 7th Int’l Symp. on Healthy Aging: 73. 2012. |
| Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulation of AMPA-type glutamate receptor trafficking by proheparanase in synaptic plasticity, Society Neuroscience Abstract (USA), 870.09/D41. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of proheparanase in synaptic plasticity at the hippocampus, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18, B199. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Shum D.K.Y. and Chan Y.S., The role of proheparanase in synaptic plasticity at the hippocampus, 9th Biennial Conference of the Chinese Neuroscience Society and The 5th Member Congress, Zhengzhou, China. Jul 29 - Aug 1, P-110. 2011. |
| Researcher : Chen Z |
| Project Title: | A novel model for the study of lung pathogenesis of SARS |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 08/2007 |
| Project Title: | Understanding the Ongoing HIV Epidemic in Yunnan China |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | China AIDS Initiative - General Award |
| Start Date: | 05/2008 |
| Project Title: | Preventing HIV-1 infection using a novel vaccine immunogen |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Global Health Grants |
| Start Date: | 10/2008 |
| Project Title: | Role of the PD-1/PD-L pathway in HIV-1 vaccine design |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2009 |
| Project Title: | Characterization of novel anti-HIV/TB natural product analogues |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2010 |
| Project Title: | Investigation of HIV-1 new outbreaks in Fujian, China |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2012 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2010 |
| Project Title: | Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 05/2011 |
| Project Title: | A Novel Vaccine for Mesothelioma Immunotherapy and Prevention; |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2011 |
| Project Title: | A promising mucosal prime and intramuscular boost AIDS vaccine regimen |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2011 |
| Project Title: | A Novel Vaccine for Tuberculosis Prevention |
| Investigator(s): | Chen Z, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2011 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Researcher : Cheung KLA |
| Project Title: | Transmission of HIV from infected myeloid progenitor cells to T cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499. |
| Researcher : Cheung KW |
| Project Title: | Effect of HIV-1 infected gut mucosa-type monocyte/macrophage on CD4 T cell fate |
| Investigator(s): | Cheung KW, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Chan G.C.F., Cheung K.W. and Sze M.Y., The Immunomodulatory and Anticancer Properties, Clinical Reviews in Allergy and Immunology. 2012, in press. |
| Researcher : Chu ACY |
| List of Research Outputs |
| Chan K.H., Zhang R., Kwan S.C., Guo Y., Ho W.L., Ho W.M. and Chu A.C.Y., Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse, Journal of Neuroimmunology. 2012, 245: 32-38. |
| Researcher : Geng L |
| List of Research Outputs |
| Fu J.D., Rushing S.N., Lieu D.K., Chan C.W.Y., Kong M.C.W., Geng L., Wilson K.D., Chiamvimonvat N., Boheler K.R. and Wu J.C., Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes, PLoS One. 2011, 6(11): e27417. |
| Kong M.C.W., Chen S., Geng L., Sun D. and Li R.A., Laser and chemical induced fusion to reverse engineer the physical size of hESC-derived CMs: a nongenetic approach for driven physiological hypertrophy and maturation., Days of Molecular Medicine 2011. |
| Li R.A., Chan C.W.Y., Kong M.C.W., Kenneth R. Boheler K.B., Ji-Dong Fu J.D.F., Stephanie N. Rushing, S.R., Deborah K. Lie D.L., Geng L., Kitchener D. Wilson K.W., Nipavan Chiamvimonvat N.C. and Joseph C. Wu J.W., Gordon Keller G.K., Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes., PloS One. 6(11):e27417.. 2011. |
| Researcher : He M |
| Project Title: | Regulation of ion channels by angiotensin II in human cardiac fibroblasts |
| Investigator(s): | He M, Li GR |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| List of Research Outputs |
| He M., Liu W., Sun H., Wu W., Liu J., Tse H.F., Lau C.P. and Li G.R., Effects of ion channels on proliferation in cultured human cardiac fibroblasts., J Mol Cell Cardiol. 2011, 51(2): 198-206. |
| Researcher : Ho PC |
| Project Title: | A double-blind randomized placebo controlled trial on the use of misoprostol with or without letrozole for termination of second trimester pregnancy |
| Investigator(s): | Ho PC, Ng EHY, Yeung WSB, Lee VCY |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2010 |
| Completion Date: | 07/2011 |
| Project Title: | Studies on the effects of ulipristal on sperm functions |
| Investigator(s): | Ho PC, Ng EHY, Li RHW, Yeung WSB, Chiu CN |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Huang W., Chiu C.N., Yeung W.S.B. and Ho P.C., Sperm fucosyltransferase-5 interacts with oviductal cell membrane proteins to protect human spermatozoa from oxidative stress., In: Society for the Study of Reproduction, 44th Annual Meeting of the Society for the Study of Reproduction. Portland, Oregon, U.S.A., JUL 31-AUG 4.. U.S.A., 2011. |
| Researcher : Hui EC |
| Project Title: | Promotion of the reflection, dialogue and teaching of ethical issues related to the development and uses of biotechnologies among students and faculty members of health-related sciences at the University of Hong Kong |
| Investigator(s): | Hui EC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 03/2005 |
| Researcher : Ip MSM |
| Project Title: | The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea |
| Investigator(s): | Ip MSM |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 02/1997 |
| Project Title: | The effect of oral appliance (OA) in treatment of obstructive sleep apnoea |
| Investigator(s): | Ip MSM, Peh WCG, Cooke MS |
| Department: | Medicine |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/1997 |
| Project Title: | Role of adiponectin in obstructive sleep apnoea |
| Investigator(s): | Ip MSM, Lam KSL |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese |
| Investigator(s): | Ip MSM, Lam KSL, Song Y, Sham PC |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| List of Research Outputs |
| Chan L.K., Lu J., Ip M.S.M. and Yip L.M., Primacy of learning in introducing technology into PBL, The 13th Medical Education Conference for China Mainland, Taiwan and the Hong Kong Region, 25-26 November. Hong Kong, 2011. |
| McGrath C.P.J., Ahrens A., Hagg E.U.O., Sam K. and Ip M.S.M., Bed partners' perspectives in a clinical trial of sleep apnoea, Journal of Dental Research. 2012, 91 (Spec Iss B): 3107. |
| Researcher : Lai WWK |
| Project Title: | Open label, prospective, double arm, randomized, pilot study to evaluate the safety and efficacy of the same day administration of PDT with verteporfin and an intravitreal injection of ranibizumab vs. ranibizumab monotherapy for the treatment of subfoveal CNV secondary to neovascular age related macular degeneration in the Asian population |
| Investigator(s): | Lai WKW, Li KKW, Wong DSH, McGhee S, Lam CLK, Chan WSC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 07/2008 |
| Project Title: | Production of Iris Pigment Epithelial Cells for transplantation to treat Age-Related Macular Degeneration |
| Investigator(s): | Lai WKW, Lo ACY, Fletcher C, Wong DSH |
| Department: | Eye Institute |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2009 |
| Project Title: | To introduce ranibizumab (Licentis) for the treatment of diabetic macular edema to Queen Mary Hospital and to access the quality of life and utility values before and after the treatment |
| Investigator(s): | Lai WKW, Wong DSH, Li KKW |
| Department: | Eye Institute |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 07/2010 |
| Researcher : Lam SK |
| Project Title: | Biotech Company in the Faculty of Medicine, The University of Hong Kong |
| Investigator(s): | Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Project Title: | Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system |
| Investigator(s): | Lam SK, Wong BCY, Lin MC |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2004 |
| Researcher : Lau YL |
| Project Title: | A community-based educational program on thalassaemias to enhance awareness with the aim to reduce burden of thalassaemia related health problems in Hong Kong |
| Investigator(s): | Lau YL, Ha SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Promotion Projects |
| Start Date: | 09/1997 |
| Project Title: | Comparison of process upgrade varicella vaccine (Puvv) with VARILRIX-TM |
| Investigator(s): | Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1999 |
| Project Title: | Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS |
| Investigator(s): | Lau YL, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2005 |
| Project Title: | p21 gene polymorphism with systemic lupus erythematosus and rheumatoid arthritis |
| Investigator(s): | Lau YL, Lau WCS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Association of STAT4, ITGAM, BLK and PXK gene polymorphisms with systemic lupus erythematosus (SLE) |
| Investigator(s): | Lau YL, Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| Project Title: | Serum cytokine profiles of SLE patients and their correlations to susceptibility genes |
| Investigator(s): | Lau YL, Yang W, Zhang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2010 |
| Completion Date: | 10/2011 |
| Project Title: | Identification of coding variants associated with early-onset and familial systemic lupus erythematosus through whole exome sequencing and replication |
| Investigator(s): | Lau YL, Sham PC, Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2011 |
| List of Research Outputs |
| Tu W., Lau Y.L., Liu Y. and Zheng J., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a {gamma}{delta} T cell population in humanized mice, J Exp Med. 2011 Jul 4;208(7):1511-22.. 2011. |
| Researcher : Li CB |
| Project Title: | Enhancement of innate immunity to the pathogen infection: anti-mycobacterial effect of IL-17 |
| Investigator(s): | Li CB, Lau ASY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2009 |
| Project Title: | Anti-oxidative effects and the underlying mechanisms of Ligusticum chuanxiong in neuronal cells |
| Investigator(s): | Li CB, Lau ASY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | 9th Joint Meeting of ICS-ISICR A role for interleukin 17 in mycobacterial infection |
| Investigator(s): | Li CB |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2011 |
| Completion Date: | 10/2011 |
| Project Title: | A role for proto-oncogene c-Myc in antibiotics-sensitive and -resistant bacteria-induced immune responses: a potential building block for the new treatment development |
| Investigator(s): | Li CB, Lau ASY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2011 |
| List of Research Outputs |
| Ling W.L., Wang L., Yim H.C.H., Lau A.S.Y. and Li C.B., A role for interleukin 17 in mycobacterial infection, 9th Joint Meeting of ICS-ISICR CYTOKINES AND INTERFERONS: FROM THE BENCH TO THE BEDSIDE. 2011. |
| Ling W.L., Wang L., Lau A.S.Y. and Li C.B., A role of IL-17A in modulating intracellular survival of Mycobacterium bovis BCG in murine macrophages, The IL-17 and Related Cytokines Conference, Dublin. 2012. |
| Yim H.C.H., Li C.B., Pong C.H. and Lau A.S.Y., A role for c-Myc in regulating anti-mycobacterial responses , Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2011;108(43):17749-54. 2011. |
| Researcher : Li G |
| Project Title: | The 10th International Conference on Alzheimer's Disease and Related Disorders High Field MRI Study of the Beta Amyloid and Plaque Desposits in the Brain of APP/PS1 Mice CoQ10 Delays the Brain Atrophy in Transgenic Aged Mice: in Vivo Volume MRI Study |
| Investigator(s): | Li G |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2006 |
| Project Title: | Effect of imbalance of kinases and protein phosphatases on deposit of B amyloid and Tau Pathology in double transgenic APP/PS1 Mice |
| Investigator(s): | Li G, Yang X, Yang ES |
| Department: | Medical Faculty |
| Source(s) of Funding: | Germany/Hong Kong Joint Research Scheme |
| Start Date: | 01/2007 |
| Researcher : Li J |
| List of Research Outputs |
| Yuan T., Li J. and Zhang M., A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins, MAbs. 2011, 3(4). |
| Zhang M., Yuan T., Rosa Borges A., Watkins J.D., Guenaga J., Yang Z., Li J., Wang Y., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41 , The 8th Annual Protein Engineering Summit, Boston, USA. 2012. |
| Researcher : Liu L |
| Project Title: | Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong |
| Investigator(s): | Liu L |
| Department: | Medical Faculty |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 09/2009 |
| Project Title: | Identification of small molecule HIV-1 inhibitors with distinct new targets |
| Investigator(s): | Liu L |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2012 |
| Project Title: | The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1 |
| Investigator(s): | Liu L, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| List of Research Outputs |
| Liu Z., Liu L., Chen Z., Xu M., Zhang T., Jiao Y., Sheng B., Chen D. and Wu H., Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China, Epidemiol. Infect.. 2012, 26: 1-11. |
| Lu X., Liu L., Zhang X., Lau T.C., Tsui S.K., Kang Y., Zheng P., Zheng B., Liu G. and Chen Z., F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis, Antimicrob Agents Chemother. 2012, Jan: 56(1): 341-51. |
| Researcher : Ng J |
| List of Research Outputs |
| Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499. |
| Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Liu L. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. JAIDS, 2012, 60: 328. |
| Researcher : Poon NYE |
| List of Research Outputs |
| Li R.A. and Poon N.Y.E., MicroRNA- and Pluripotent Stem Cell-based Heart Therapies: From the Electrophysiological Perspectives, Mol Pharm. 8(5):1495-504. PMID:21879736. 2011. |
| Researcher : Rong J |
| Project Title: | The 7th International Conference on Systems Biology Genome-wide Biological Response Fingerprinting (BioReF) of Traditional Chinese Medicine Formula ISF-1 Reveals a Potential Role of Heme Oxygenase-1 Pathway in the Antioxidant Therapy |
| Investigator(s): | Rong J |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2006 |
| Project Title: | Synergistic neurotoxic effects of (Z)-ligustilide and dopamine in rat dopaminergic cell line PC12: Implications for the pathogenesis of Parkinson’s disease (PD) |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | 16th WORLD CONGRESS ON HEART DISEASE Pharmacological induction of leukotriene B4 12-hydroxydehydrogenase (LTB4DH) in human neutrophils and its potential in the treatment of myocardial injury |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2011 |
| Completion Date: | 07/2011 |
| Project Title: | Novel role of actin-binding protein α-actinin 4 in the regulation of hydrogen peroxide-induced NF-κB activation by Chinese medicine puerarin |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis |
| Investigator(s): | Sham PC, Gao RY, Xiao S, Kung AWC |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2010 |
| Project Title: | Genetic studies of endophenotypes for psychosis |
| Investigator(s): | Sham PC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | Method and Software for Personal Risk Profiling of Complex Diseases |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene, European Journal of Endocrinology 2011. 2011, 165: 571-577. |
| Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Fong H.Y., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 19. |
| Guo Y., Baum L.W., Sham P.C., Wong V.C.N., Ng P.W., Lui C.H.T., Sin N.C., Tsoi T.H., Tang C.S.M., Kwan S.H., Yip B.H.K., Xiao S., Thomas G.N., Lau Y.L., Yang W., Cherny S.S. and Kwan P., Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese, Human Molecular Genetics. 2011, 21: 1184-1189. |
| Kwan S.H., Xiao S., Bow C.H.Y., Cheung C.L., Soong S.S., Lau K.S., Kung A.W.C. and Sham P.C., Heritability Of Serum Osteoprotegerin, Annals Of Human Genetics. 2011. |
| Researcher : Smith DK |
| Project Title: | Patterns in proteins with unusual flexibility profiles |
| Investigator(s): | Smith DK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 08/2002 |
| List of Research Outputs |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85. |
| Researcher : Wang H |
| Project Title: | Induction of gp41-specific IgA to prevent HIV infection. |
| Investigator(s): | Wang H, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499. |
| Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Liu L. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. JAIDS, 2012, 60: 328. |
| Researcher : Wang L |
| List of Research Outputs |
| Ling W.L., Wang L., Yim H.C.H., Lau A.S.Y. and Li C.B., A role for interleukin 17 in mycobacterial infection, 9th Joint Meeting of ICS-ISICR CYTOKINES AND INTERFERONS: FROM THE BENCH TO THE BEDSIDE. 2011. |
| Ling W.L., Wang L., Lau A.S.Y. and Li C.B., A role of IL-17A in modulating intracellular survival of Mycobacterium bovis BCG in murine macrophages, The IL-17 and Related Cytokines Conference, Dublin. 2012. |
| Researcher : Wong DSH |
| Project Title: | Inhibition of provisional matrix synthesis in proliferative vitreoretinopathy (PVR) prevention |
| Investigator(s): | Wong DSH, Lo ACY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2008 |
| Project Title: | To introduce bevacizumab for the treatment of macular degeneration and diabetic retinopathy to Queen Mary Hospital |
| Investigator(s): | Wong DSH, Lai WKW, Li KKW |
| Department: | Medical Faculty |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2008 |
| Project Title: | To develop a tool that can be used to study patients with eye diseases in Hong Kong, namely a translated Chinese version of the established Visual Function Questionnaire (VFQ-25) |
| Investigator(s): | Wong DSH, Lai WKW, McGhee S, Lam CLK, Chan WSC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 07/2008 |
| Project Title: | The Royal College of Ophthalmologists Annual Congress 2009 Can Lutein Protect the Outer Retina? |
| Investigator(s): | Wong DSH |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Effectiveness of lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma: A randomized controlled trial (EAGLE) |
| Investigator(s): | Wong DSH, Lai JSM |
| Department: | Eye Institute |
| Source(s) of Funding: | Medical Research Council (MRC) - General Award |
| Start Date: | 09/2009 |
| Project Title: | Prioritising patients using quality of life and visual acuity: how should we select and prioritise patients for cataract surgery? |
| Investigator(s): | Wong DSH, McGhee S |
| Department: | Eye Institute |
| Source(s) of Funding: | Health and Health Services Research Fund - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | XXVIIIth Meeting of the Club Jules Gonin WHAT IS THE MOST EFFECTIVE WAY OF PREVENTING EMULSIFICATION OF SILICONE OIL |
| Investigator(s): | Wong DSH |
| Department: | Eye Institute |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Wong Y.H.I., Poon M.W., Pang R.T., Lian Q. and Wong D.S.H., Promises of stem cell therapy for retinal degenerative diseases, Graefe's Archive of Clinical and Experimental Ophthalmology. 2011, 249 (10): 1439-1448. |
| Researcher : Xia F |
| Project Title: | Roles of liver-secreted factors, FGF21 and adropin, in energy homeostasis and insulin sensitivity |
| Investigator(s): | Xia F, Xu A, Lam KSL |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2009 |
| Researcher : Yang LH |
| List of Research Outputs |
| Yang L.H., Or C.T., Lau J.S.-.H. and Lau A.S.Y., Ligusticum chuanxiong and its decoctions: effects and underlying mechanisms of action on stroke, Advances in Botanical Research. 2012, 62: 315-341. |
| Researcher : Yau JMH |
| Project Title: | Angiopoietin-like proteins 3 and 4 as novel inhibitors of lipoprotein lipase: functional and structural studies |
| Investigator(s): | Yau JMH, Xu A, Lam KSL |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2006 |
| Researcher : Yim HCH |
| List of Research Outputs |
| Ling W.L., Wang L., Yim H.C.H., Lau A.S.Y. and Li C.B., A role for interleukin 17 in mycobacterial infection, 9th Joint Meeting of ICS-ISICR CYTOKINES AND INTERFERONS: FROM THE BENCH TO THE BEDSIDE. 2011. |
| Yim H.C.H., Li C.B., Pong C.H. and Lau A.S.Y., A role for c-Myc in regulating anti-mycobacterial responses , Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2011;108(43):17749-54. 2011. |
| Researcher : Zhang H |
| List of Research Outputs |
| Zhang Q., Zhang X., Wu H., Seto D., Zhang H., Chen Z., Wan C.S. and Zheng B., Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC, PLoS ONE. 2012, 7(2): e31233. |
| Researcher : Zhang M |
| Project Title: | Identification of HIV-1 vaccine immunogens by antibody in vitro maturation |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 12/2009 |
| Completion Date: | 06/2012 |
| Project Title: | Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Development of yeast display technology for antibody engineering |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 02/2012 |
| Project Title: | Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 08/2011 |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2011 |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M, Srivastava V, Li J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2011 |
| Project Title: | Eighth Annual Protein Engineering Summit (PEGS) Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41 |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2012 |
| Project Title: | Development of intrabodies targeting eukaryotic translation initiation factor 5A2 for cancer treatment |
| Investigator(s): | Zhang M, Guan X |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2012 |