MEDICAL FACULTY
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Determinants of developmental plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Brain-derived neurotrophic factor regulates plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Project Title: | 42nd Annual Meeting of Society for Neuroscience; Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2012 |
| Project Title: | Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| List of Research Outputs |
| Chan Y.S., Li C., Han L., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations, Society Neuroscience Abstract (USA), 470.12/DD17. 2012. |
| Ma C.W., Zhang F.X., Lai C.H., Lai S.K., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations, Journal of Comparative Neurology. 2013, 521: 612-625. |
| Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Society Neuroscience Abstract (USA), 845.23/C18. 2012. |
| Ma C.W., Lam Y.L., Cham W.C., Han L., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic function of the central vestibular system, Gordon Research Conferences (Proteoglycans), Andover, USA. Jul 8-13. 2012. |
| Ma C.W., Lai C.H., Chow B.K.C., Shum D.K.Y. and Chan Y.S., Topography of inferior olivary neurons that encode canal and otolith inputs, Cerebellum. 2013, 12: 322-324. |
| Researcher : Chen Z |
| Project Title: | A novel model for the study of lung pathogenesis of SARS |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 08/2007 |
| Project Title: | Understanding the Ongoing HIV Epidemic in Yunnan China |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | China AIDS Initiative - General Award |
| Start Date: | 05/2008 |
| Project Title: | Preventing HIV-1 infection using a novel vaccine immunogen |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Global Health Grants |
| Start Date: | 10/2008 |
| Project Title: | Role of the PD-1/PD-L pathway in HIV-1 vaccine design |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2009 |
| Completion Date: | 11/2012 |
| Project Title: | Investigation of HIV-1 new outbreaks in Fujian, China |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2012 |
| Project Title: | Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 05/2011 |
| Project Title: | A Novel Vaccine for Mesothelioma Immunotherapy and Prevention; |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2011 |
| Project Title: | A promising mucosal prime and intramuscular boost AIDS vaccine regimen |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2011 |
| Project Title: | A Novel Vaccine for Tuberculosis Prevention |
| Investigator(s): | Chen Z, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2011 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV. |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2012 |
| Project Title: | Mechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Novel Secretory Immunoadhesins for HIV Prevention |
| Investigator(s): | Chen Z, Cheung KLA |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| List of Research Outputs |
| Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. . |
| Cheung K.L.A. and Chen Z., Novel PD1-based DNA vaccines in amplifying HIV-1 GAG-Specific CD8+ T cells in mice, 中国艾滋病疫苗联盟与世界卫生组织-联合国艾滋病规划署 艾滋病疫苗咨询委员会联合会议, Joint meeting between the Chinese AIDS Vaccine Initiative (CAVI) and the WHO-UNAIDS HIV Vaccine Advisory Committee (VAC). 2013. |
| Researcher : Cheng L |
| List of Research Outputs |
| Qiu M., Chen Y., Song S., Song H., Chu Y., Yuan Z., Cheng L., Zheng D., Chen Z. and Wu Z., Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections – Potential as a dual functional microbicide, Antiviral Research. 2012, 96: 138-147. |
| Researcher : Cheung KLA |
| Project Title: | Transmission of HIV from infected myeloid progenitor cells to T cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Project Title: | Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | Immunology 2013; A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity |
| Investigator(s): | Cheung KLA |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. . |
| Cheung K.L.A. and Chen Z., Novel PD1-based DNA vaccines in amplifying HIV-1 GAG-Specific CD8+ T cells in mice, 中国艾滋病疫苗联盟与世界卫生组织-联合国艾滋病规划署 艾滋病疫苗咨询委员会联合会议, Joint meeting between the Chinese AIDS Vaccine Initiative (CAVI) and the WHO-UNAIDS HIV Vaccine Advisory Committee (VAC). 2013. |
| ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642. |
| Researcher : Cheung KW |
| Project Title: | Effect of HIV-1 infected gut mucosa-type monocyte/macrophage on CD4 T cell fate |
| Investigator(s): | Cheung KW, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 04/2013 |
| Project Title: | Type of cell death and related mechanisms for gut homing CD4 T cells during human immunodeficiency virus-1 (HIV-1) infection |
| Investigator(s): | Cheung KW, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Researcher : Du Y |
| List of Research Outputs |
| Sun C., Chen Z., TANG X., Zhang Y., Feng L., Du Y., xiao L., Liu L., Zhu W. and Chen L., Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys, Journal of Virology. 2013, 87: 5669-5677. |
| ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642. |
| Researcher : He M |
| Project Title: | Regulation of ion channels by angiotensin II in human cardiac fibroblasts |
| Investigator(s): | He M, Li GR |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Researcher : Ho PC |
| Project Title: | Studies on the effects of ulipristal on sperm functions |
| Investigator(s): | Ho PC, Ng EHY, Li RHW, Yeung WSB, Chiu CN |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| Chiu C.N., Lee C.L., Zhao W., Huang W., Lam K.W., Ho P.C. and Yeung W.S.B., Identification of sialyl-Lewis(x) (SLEX)-binding protein on human spermatozoa and its role on sperm-zona pellucida interaction, In: European Society of Human Reproduction and Embryology, 28th Annual Meeting of the European Society of Human Reproduction and Embryology . 2012, O-289. |
| Huang W., Yeung W.S.B., Ho P.C. and Chiu C.N., Sperm Fucosyltransferase-5 is involved in Spermatozoa-oviductal Epithelial Cell Interaction to Protect Human Spermatozoa from Oxidative Damage, 2013 Glycobiology Gordon Research Conference, Ventura, CA, March 3-8, 2013. . |
| Researcher : Hui EC |
| Project Title: | Promotion of the reflection, dialogue and teaching of ethical issues related to the development and uses of biotechnologies among students and faculty members of health-related sciences at the University of Hong Kong |
| Investigator(s): | Hui EC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 03/2005 |
| Researcher : Lai WWK |
| Project Title: | Open label, prospective, double arm, randomized, pilot study to evaluate the safety and efficacy of the same day administration of PDT with verteporfin and an intravitreal injection of ranibizumab vs. ranibizumab monotherapy for the treatment of subfoveal CNV secondary to neovascular age related macular degeneration in the Asian population |
| Investigator(s): | Lai WKW, Li KKW, Wong DSH, McGhee S, Lam CLK, Chan WSC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Pharmaceutical Industry - General Award |
| Start Date: | 07/2008 |
| Project Title: | Production of Iris Pigment Epithelial Cells for transplantation to treat Age-Related Macular Degeneration |
| Investigator(s): | Lai WKW, Lo ACY, Fletcher C, Wong DSH |
| Department: | Eye Institute |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2009 |
| Project Title: | To introduce ranibizumab (Licentis) for the treatment of diabetic macular edema to Queen Mary Hospital and to access the quality of life and utility values before and after the treatment |
| Investigator(s): | Lai WKW, Wong DSH, Li KKW |
| Department: | Eye Institute |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 07/2010 |
| Researcher : Lam SK |
| Project Title: | Biotech Company in the Faculty of Medicine, The University of Hong Kong |
| Investigator(s): | Lam SK |
| Department: | Medicine |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Project Title: | Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system |
| Investigator(s): | Lam SK, Wong BCY, Lin MC |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2004 |
| Researcher : Li CB |
| Project Title: | A role for oncogenes in the regulation of immune response to Mycobacterial infection |
| Investigator(s): | Li CB |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Anti-oxidative effects and the underlying mechanisms of Ligusticum chuanxiong in neuronal cells |
| Investigator(s): | Li CB, Lau ASY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Completion Date: | 03/2013 |
| Project Title: | Cellular Oncogene Dysregulation of Chemokine and Cytokine Expression in Influenza Virus Infection |
| Investigator(s): | Li CB, Leon YY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2011 |
| Project Title: | A role for proto-oncogene c-Myc in antibiotics-sensitive and -resistant bacteria-induced immune responses: a potential building block for the new treatment development |
| Investigator(s): | Li CB |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2011 |
| Project Title: | Immunology 2013; The effects of HIV-1 Tat protein on mycobacterial infection |
| Investigator(s): | Li CB |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Li C.B., Associate Editor, Deputy Section Editor, BMC Immunology. 2012. |
| Li C.B., BMC Immunology, Section Editor, BMC Immunology. 2012. |
| Pong C.H., Li C.B., Yim H.C.H. and Lau A.S.Y., THE ROLE OF C-MYC IN REGULATING HIV-1 TAT PROTEIN INDUCED CYTOKINE EXPRESSION AND CONSEQUENT EFFECTS ON OPPORTUNISTIC INFECTION, 10th Joint Annual Meeting of the International Cytokine Society (ICS) and the International Society for Interferon and Cytokine Research (ISICR). 2012. |
| Researcher : Li G |
| Project Title: | The 10th International Conference on Alzheimer's Disease and Related Disorders High Field MRI Study of the Beta Amyloid and Plaque Desposits in the Brain of APP/PS1 Mice CoQ10 Delays the Brain Atrophy in Transgenic Aged Mice: in Vivo Volume MRI Study |
| Investigator(s): | Li G |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2006 |
| Project Title: | Effect of imbalance of kinases and protein phosphatases on deposit of B amyloid and Tau Pathology in double transgenic APP/PS1 Mice |
| Investigator(s): | Li G, Yang X, Yang ES |
| Department: | Medical Faculty |
| Source(s) of Funding: | Germany/Hong Kong Joint Research Scheme |
| Start Date: | 01/2007 |
| Researcher : Li J |
| List of Research Outputs |
| Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012. |
| Researcher : Li RA |
| Project Title: | Non-cell autonomous directed maturation of developmentally arrested hESC/iPSC-derived cardiomyocytes |
| Investigator(s): | Li RA |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Completion Date: | 12/2012 |
| Project Title: | Cell-based Heart Regeneration |
| Investigator(s): | Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2011 |
| List of Research Outputs |
| Jiang P., Salvaraj V., Liu W., Feldman D.K., Liu Y., Pleasure D., Li R.A. and Deng W., Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells. Stem Cells. 2013 Aug 13. doi: 10.1002/stem.1515. [Epub ahead of print] PMID: 23940003, 2013. |
| Li R.A., Engineering human heart cells and tissues from human pluripotent stem cells. Bioprocessing Unit, Biopolis, Singapore. , 2013. |
| Li R.A., Engineering human heart cells and tissues from human pluripotent stem cells. Department of Biomedical Engineering. U of California, Irvine. , 2013. |
| Li R.A., Engineering human heart cells and tissues. St Michael's Hospital / Canadian Heart Research Centre. U of Toronto. , 2013. |
| Li R.A., Gadgets for cardiovascular drug discovery and disease modeling. Heart Brain Hormone and Healthy Aging Center. , 2013. |
| Li R.A., Gadgets for cardiovascular drug discovery and disease modeling. Hong Kong Science and Technology Park., 2013. |
| Li R.A., Gadgets for cardiovascular drug discovery and disease modeling. Pfizer., 2013. |
| Researcher : Liu H |
| List of Research Outputs |
| Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. . |
| Researcher : Liu L |
| Project Title: | Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong |
| Investigator(s): | Liu L |
| Department: | Medical Faculty |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 09/2009 |
| Project Title: | Identification of small molecule HIV-1 inhibitors with distinct new targets |
| Investigator(s): | Liu L |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2012 |
| Project Title: | The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1 |
| Investigator(s): | Liu L, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| List of Research Outputs |
| Liu Z., Liu L., Chen Z., Xu M., Zhang T., Jiao Y., Sheng B., Chen D. and Wu H., Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China, Epidemiology and Infection. 2012, 140: 2199-2209. |
| Sun C., Chen Z., TANG X., Zhang Y., Feng L., Du Y., xiao L., Liu L., Zhu W. and Chen L., Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys, Journal of Virology. 2013, 87: 5669-5677. |
| ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642. |
| Researcher : Lok S |
| Project Title: | Generation of ferret (Mustela putorius furo) genomic resources for respiratory infectious disease research: Transcriptomics and comprehensive characterization of cDNAs in a model of influenza infection |
| Investigator(s): | Lok S, Tong AHY, Lee MY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Kwok H., Tong A.H.Y., Lin C., Lok S., Ferrell P.J., Kwong D.L.W. and Chiang A.K.S., Genomic Sequencing and Comparative Analysis of Epstein-Barr Virus Genome Isolated from Primary Nasopharyngeal Carcinoma Biopsy, 17th Research Postgrduate Symposium, Dec 12-13, 2012. 167. |
| Researcher : Ng J |
| List of Research Outputs |
| Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Lau E., Li L., Wu J. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. 2012, 60(3): 328-335. |
| Researcher : Rong J |
| Project Title: | The 7th International Conference on Systems Biology Genome-wide Biological Response Fingerprinting (BioReF) of Traditional Chinese Medicine Formula ISF-1 Reveals a Potential Role of Heme Oxygenase-1 Pathway in the Antioxidant Therapy |
| Investigator(s): | Rong J |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2006 |
| Project Title: | Novel role of actin-binding protein α-actinin 4 in the regulation of hydrogen peroxide-induced NF-κB activation by Chinese medicine puerarin |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Project Title: | Pharmacological induction of leukotriene B4 12-hydroxydehydrogenase (LTB4DH) for the resolution of neutrophil-induced myocardial injury |
| Investigator(s): | Rong J, Lau ASY, Li XC, Tse HF, Xia Z |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | The 2nd International Congress on Neurology and Epidemiology (ICNE) ; Roles of PI3K/Akt and Nrf2-Keap1 pathways in the hormetic effect of Z-ligustilide on PC12 cells against oxygen and glucose deprivation |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2012 |
| Completion Date: | 11/2012 |
| Project Title: | Regulation of neutrophil survival and migration in ischemic stroke by Chinese medicines Radix Astragali and Radix Paeoniae Rubrae via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) |
| Investigator(s): | Rong J |
| Department: | School of Chinese Medicine |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis |
| Investigator(s): | Sham PC, Gao RY, Xiao S, Kung AWC |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2010 |
| Project Title: | Genetic studies of endophenotypes for psychosis |
| Investigator(s): | Sham PC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | Predicting and preventing schizophrenia in the mouse model. |
| Investigator(s): | Sham PC, Wu EX, McAlonan GM, Cheung C, Chua SE |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Method and Software for Personal Risk Profiling of Complex Diseases |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Bioinformatics tools for identifying disease loci from exome sequencing data |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Researcher : Wang H |
| Project Title: | Induction of gp41-specific IgA to prevent HIV infection. |
| Investigator(s): | Wang H, Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Lau E., Li L., Wu J. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. 2012, 60(3): 328-335. |
| ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642. |
| Researcher : Wong DSH |
| Project Title: | Inhibition of provisional matrix synthesis in proliferative vitreoretinopathy (PVR) prevention |
| Investigator(s): | Wong DSH, Lo ACY |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2008 |
| Project Title: | To introduce bevacizumab for the treatment of macular degeneration and diabetic retinopathy to Queen Mary Hospital |
| Investigator(s): | Wong DSH, Lai WKW, Li KKW |
| Department: | Medical Faculty |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2008 |
| Project Title: | To develop a tool that can be used to study patients with eye diseases in Hong Kong, namely a translated Chinese version of the established Visual Function Questionnaire (VFQ-25) |
| Investigator(s): | Wong DSH, Lai WKW, McGhee S, Lam CLK, Chan WSC |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 07/2008 |
| Project Title: | The Royal College of Ophthalmologists Annual Congress 2009 Can Lutein Protect the Outer Retina? |
| Investigator(s): | Wong DSH |
| Department: | Medical Faculty |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Effectiveness of lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma: A randomized controlled trial (EAGLE) |
| Investigator(s): | Wong DSH, Lai JSM |
| Department: | Eye Institute |
| Source(s) of Funding: | Medical Research Council (MRC) - General Award |
| Start Date: | 09/2009 |
| Project Title: | Prioritising patients using quality of life and visual acuity: how should we select and prioritise patients for cataract surgery? |
| Investigator(s): | Wong DSH, McGhee S |
| Department: | Eye Institute |
| Source(s) of Funding: | Health and Health Services Research Fund - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | XXVIIIth Meeting of the Club Jules Gonin WHAT IS THE MOST EFFECTIVE WAY OF PREVENTING EMULSIFICATION OF SILICONE OIL |
| Investigator(s): | Wong DSH |
| Department: | Eye Institute |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2012 |
| Project Title: | To develop a new surgical strategy for removing emulsified droplets in the eye and thereby reducing the complications associated with silicone tamponade. |
| Investigator(s): | Wong DSH |
| Department: | Eye Institute |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Researcher : Wong YL |
| List of Research Outputs |
| Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012. |
| Researcher : Xia F |
| Project Title: | Roles of liver-secreted factors, FGF21 and adropin, in energy homeostasis and insulin sensitivity |
| Investigator(s): | Xia F, Xu A, Lam KSL |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2009 |
| Researcher : Yang LH |
| Project Title: | Discovery and Validation of antiviral small-molecule inhibitors for influenza virus replication |
| Investigator(s): | Yang LH, Law HY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2012 |
| List of Research Outputs |
| Law H.Y., Yang L.H. and Lau A.S.Y., Mechanism of action and molecular identification of individual bio-active constituents from an effective traditional Chinese medicine decoction in treating influenza virus infection., Science Translational Medicine (in press). 2012. |
| Yang L.H., Or C.T., Ho M.H.K. and Lau A.S.Y., Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis, Clinical Reviews in Allergy & Immunology. 2012, 2012: 1-17. |
| Researcher : Yau JMH |
| Project Title: | Angiopoietin-like proteins 3 and 4 as novel inhibitors of lipoprotein lipase: functional and structural studies |
| Investigator(s): | Yau JMH, Xu A, Lam KSL |
| Department: | Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2006 |
| Researcher : Yeung DWC |
| List of Research Outputs |
| Lo J., Yau Y.Y., Yeung D.W.C. and Cheung L.K., Planar scintigraphy in assessment of mandibular asymmetry: Unilateral condylar hyperplasia vs asymmetric mandibular hyperplasia, Journal of Biomedical Science and Engineering. 2012, 5 (12A): 836-844. |
| Researcher : Yim HCH |
| List of Research Outputs |
| Pong C.H., Li C.B., Yim H.C.H. and Lau A.S.Y., THE ROLE OF C-MYC IN REGULATING HIV-1 TAT PROTEIN INDUCED CYTOKINE EXPRESSION AND CONSEQUENT EFFECTS ON OPPORTUNISTIC INFECTION, 10th Joint Annual Meeting of the International Cytokine Society (ICS) and the International Society for Interferon and Cytokine Research (ISICR). 2012. |
| Researcher : Yu W |
| List of Research Outputs |
| ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642. |
| Researcher : Zhang M |
| Project Title: | Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 08/2011 |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2011 |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M, Srivastava V, Li J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2011 |
| Completion Date: | 04/2013 |
| Project Title: | Development of intrabodies targeting eukaryotic translation initiation factor 5A2 for cancer treatment |
| Investigator(s): | Zhang M, Guan X |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2012 |
| Project Title: | A novel strategy for prevention and treatment of HIV-1 infection |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2012 |
| Project Title: | Guiding the immune response: a novel approach for HIV-1 vaccine development |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Keystone Symposium--B Cell Development and Function; Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2013 |
| Completion Date: | 02/2013 |