DEPT OF MICROBIOLOGY



Researcher : CHEUNG YY

List of Research Outputs

Ho P.L., LI Z., Lo W.U., CHEUNG Y.Y., Lin C., Sham P.C., Ng T.K., Que T.L. and Chow K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China, Emerg Microbes Infect. Shanghai, 2012, 1: 39.


Researcher : Cai J

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.


Researcher : Chan CS

List of Research Outputs

Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Chan E

List of Research Outputs

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.


Researcher : Chan J

List of Research Outputs

Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., Chan J., Lo W.U., Law P.Y.T. and Chow K.H., Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig., Veterinary Microbiology. ELSEVIER, 2013, 162(2-4): 964-7.


Researcher : Chan JFW

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chen J.H.K., Cheng V.C.C., Chan J.F.W., She K.K.K., Yan M.K. and Yau M.C.Y., The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates, Journal of Microbiological Methods. 2013, 92(2): 99-102.
Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Shea Y.F., Chan J.F.W., Kwok W.C., Hwang Y.Y., Chan T.C., Ni M.Y., Li W.S., Chiu P.K.C., Luk J.K.H. and Chu L.W., Haemophagocytic lymphohistiocytosis: An uncommon clinical presentation of tuberculosis, Hong Kong Medical Journal. 2012, 18(6): 517-25.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.


Researcher : Chan KCW

List of Research Outputs

To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., TSANG O.T. and Yam W.C., HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?, Int J STD AIDS. 2013.


Researcher : Chan KH

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan K.H., To K.K.W., Chan B.W., Li C.P., Chiu S.S.S., Yuen K.Y. and Ho P.L., Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens., Journal of Clinical Microbiology . 2013, 51: 2592-2598.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Chan K.M., Ho Y.L., Lam Y.P., Tong H.L., Poon L.L.M., Cowling B.J. and Peiris J.S.M., Quantitative analysis of four rapid antigen assays for detection of pandemic H1N1 2009 compared with seasonal H1N1 and H3N2 influenza A viruses on nasopharyngeal aspirates from patients with influenza, Journal of Virological Methods. 2012, 186(1-2): 184-8.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Chu K.W., Poon L.L.M., Chiu S.S.S., Chan K.H., Ng E.M., Bauer I.R.M.A., Cheung T.I.M. .K., Ng I.H.Y., Guan Y., Wang D.A.V.I.D. and Peiris J.S.M., Characterization of a novel gyrovirus in human stool and chicken meat, Journal of Clinical Virology. 2012, 55(3): 209-13.
Cowling B.J., Ng S., Ma E.S.K., Fang J., So H.C., Lim Wai W.S., Cheng K.Y., Wong Y.T., Chan K.H., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., Protective efficacy against pandemic influenza of seasonal influenza vaccination in children in Hong Kong: A randomized controlled trial, Clinical Infectious Diseases. 2012, 55(5): 695-702.
Cowling B.J., Chan K.H., Peiris J.S.M., Riley S. and Leung G.M., Viral shedding, clinical history and transmission of influenza, Hong Kong Medical Journal. 2013, 19(Suppl 4): S19-23.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
Klick B.A., Durrani S., Chan K.H., Ip D.K.M., Chou S.K., Kwok H.K.H., Ng S., Chiu S.S.S., Peiris J.S.M., Leung G.M. and Cowling B.J., Live attenuated seasonal and pandemic influenza vaccine in school-age children: A randomized controlled trial, Vaccine. 2013, 31(15): 1937-43.
Lau L.H.L., Ip D.K.M., Nishiura H., Fang J., Chan K.H., Peiris J.S.M., Leung G.M. and Cowling B.J., Heterogeneity in viral shedding among individuals with medically attended influenza a virus infection, Journal of Infectious Diseases. 2013, 207(8): 1281-5.
Lau L.H.L., Ip D.K.M., Fang J., Chan K.H., Nishiura H., Leung G.M., Peiris J.S.M. and Cowling B.J., Variability of viral shedding dynamics among cases of influenza A virus infections (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting, 15 September 2012, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2012, Poster 2.
Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Ng S., Ip D.K.M., Fang J., Chan K.H., Chiu S.S.S., Leung G.M., Peiris J.S.M. and Cowling B.J., Efficacy and effectiveness of trivalent inactivated influenza vaccination against confirmed influenza, acute respiratory illness, and medically attended acute respiratory illness (abstract and poster presentation), Incidence, Severity, and Impact 2012: An isirv International Conference on Seasonal and Pandemic Influenza, 5-8 September 2012, Munich, Germany. Munich, Germany, ISIRV, 2012, 72.
Ng S., Ip D.K.M., Fang J., Chan K.H., Chiu S.S.S., Leung G.M., Peiris J.S.M. and Cowling B.J., The effect of age and recent influenza vaccination history on the immunogenicity and efficacy of 2009-10 seasonal trivalent inactivated influenza vaccination in children, PLoS One. 2013, 8(3): e59077.
Ng S., Ip D.K.M., Fang J., Chan K.H., Chiu S.S.S., Peiris J.S.M., Leung G.M. and Cowling B.J., Trivalent inactivated influenza vaccine and medically attended acute respiratory illnesses in children and their households, a cluster randomized controlled trial (abstract and oral presentation), Hong Kong College of Community Medicine Annual Scientific Meeting, 15 September 2012, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2012, Free paper 1.
Ning J., Chan K.H. and Chiang A.K.S., Epstein-barr Virus (EBV) - specific CD4+ and CD8_ T Cell REsponses Shift from Targeting Lytic- to Latent-cycle Proteins with Concurrent Development of Increased Polyfunctionality from the Acute to Persistent Phase of EBV Infection, 17th Research Postgraduate Symposium, Dec 12-13, 2012. 216.
Poon L.L.M., Chan K.H., Chu K.W., Fung C.C.Y., Cheng K.Y., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community. , J Clin Virol. 2012, 52: 146-150.
Riley S., Cowling B.J., Chan K.H., Peiris J.S.M. and Leung G.M., Viral evolution from one generation of human influenza infection to the next, Hong Kong Medical Journal. 2013, 19(Suppl 4): S6-10.
Shea Y.F., Chan C.Y.J., Hung I.F.N. and Chan K.H., Hand, Foot and Mouth Disease in an Immunocompetent Adult due to Coxsackievirus A6, Hong Kong Medical Journal. 2013, 19(3): 262-4.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Wei L., Ip D.K.M., Chan K.H., Fang J., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns in respiratory virus infections in children presenting to outpatient clinics with acute upper respiratory tract infections (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting, 15 September 2012, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2012, Poster 12.
Wei L., Ip D.K.M., Chan K.H., Fang J., Nishiura H., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns in respiratory virus infections in children presenting to outpatient clinics with acute upper respiratory tract infections (abstract), Incidence, Severity, and Impact 2012: An isirv International Conference on Seasonal and Pandemic Influenza, 5-8 September 2012, Munich, Germany. Munich, Germany, ISIRV, 2012, 50.
Wei L., Ip D.K.M., Chan K.H., Fang J., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns on respiratory virus infections in children presenting to outpatient clinics with acute upper respiratory tract infections (abstract and poster presentation), 17th Research Postgraduate Symposium, 12-13 December 2012, Hong Kong. Hong Kong, LKS faculty of Medicine, HKU, 2012, 156.
Yang L., Chan K.P., Cowling B.J., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Excess mortality associated with the 2009 pandemic of influenza A(H1N1) in Hong Kong, Epidemiology and Infection. 2012, 140(9): 1542-50.
Yang L., Chan K.P., Lee R.S.Y., Chan W.M., Lai H.K., Thach T.Q., Chan K.H., Lam T.H., Peiris J.S.M. and Wong C.M., Obesity and influenza associated mortality: Evidence from an elderly cohort in Hong Kong, Preventive Medicine. 2013, 56(2): 118-23.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : Chan KM

List of Research Outputs

Chan K.H., Chan K.M., Ho Y.L., Lam Y.P., Tong H.L., Poon L.L.M., Cowling B.J. and Peiris J.S.M., Quantitative analysis of four rapid antigen assays for detection of pandemic H1N1 2009 compared with seasonal H1N1 and H3N2 influenza A viruses on nasopharyngeal aspirates from patients with influenza, Journal of Virological Methods. 2012, 186(1-2): 184-8.


Researcher : Chan MCW

Project Title:Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo
Investigator(s):Chan MCW, Peiris JSM, Chan WY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2009


Project Title:Effect of allogeneic human mesenchymal stem cells on alveolar fluid clearance and protein permeability in human alveolar epithelial cells injured by influenza H5N1 virus infection
Investigator(s):Chan MCW, Nicholls JM
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract
Investigator(s):Chan MCW, Chan WY, Nicholls JM, Mak JCW
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2011


Project Title:Tropism and innate host responses in primary human cardiac myocytes infected with influenza H5N1 and H1N1pdm virus
Investigator(s):Chan MCW
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Role of indirubin-3’-oxime as an antiviral and immunomodulatory agent in the treatment of severe human influenza virus infection
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


Project Title:Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells on Acute Lung Injury Caused by Severe Influenza H5N1 Virus Infection
Investigator(s):Chan MCW, Peiris JSM, Guan Y, Chan GCF, Chan WY
Department:School of Public Health
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012


Project Title:A comparative study of influenza A viruses with differential interferon induction with respect to their potential to confer increased susceptibility to secondary bacterial infections
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:A mouse model to study the beneficial effect of human mesenchymal stem cells on acute lung injury induced by influenza H5N1 virus infection
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013




Researcher : Chan PY

List of Research Outputs

Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.


Researcher : Chan WM

List of Research Outputs

Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.


Researcher : Chen H

Project Title:Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:Seed Funding for New Staff
Start Date:07/2004


Project Title:Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Antiviral drug resistance in H5N1 virus
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2007


Project Title:Molecular basis for the regulation of influenza virus by nuclear factor NF90
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Biological functiuons of of the Epstein-Barr V irus-encoded BARTs in nasopharyngeal carcinoma
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.
Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.


Researcher : Chen JHK

Project Title:Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):Chen JHK, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/2009


List of Research Outputs

Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Chen J.H.K., Cheng V.C.C., Chan J.F.W., She K.K.K., Yan M.K. and Yau M.C.Y., The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates, Journal of Microbiological Methods. 2013, 92(2): 99-102.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., TSANG O.T. and Yam W.C., HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?, Int J STD AIDS. 2013.
Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.


Researcher : Chen M

Project Title:Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):Chen M, Zheng B
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.


Researcher : Chen Z

Project Title:A novel model for the study of lung pathogenesis of SARS
Investigator(s):Chen Z
Department:Medical Faculty
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:08/2007


Project Title:Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):Chen Z
Department:Medical Faculty
Source(s) of Funding:China AIDS Initiative - General Award
Start Date:05/2008


Project Title:Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):Chen Z
Department:Medical Faculty
Source(s) of Funding:Global Health Grants
Start Date:10/2008


Project Title:Role of the PD-1/PD-L pathway in HIV-1 vaccine design
Investigator(s):Chen Z
Department:Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2009
Completion Date:11/2012


Project Title:Investigation of HIV-1 new outbreaks in Fujian, China
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2010
Completion Date:09/2012


Project Title:Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:05/2011


Project Title:A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A promising mucosal prime and intramuscular boost AIDS vaccine regimen
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


Project Title:AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011


Project Title:A Novel Vaccine for Tuberculosis Prevention
Investigator(s):Chen Z, Yam WC
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2011


Project Title:Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):Chen Z, Liu L
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2012


Project Title:AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV.
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2012


Project Title:Mechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity
Investigator(s):Chen Z, Liu L
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Novel Secretory Immunoadhesins for HIV Prevention
Investigator(s):Chen Z, Cheung KLA
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2013


List of Research Outputs

Chen Z., A novel PD1 isoform (∆42PD1) and a specific monoclonal antibody (clone CH34) targeting ∆42PD1, 2013.
KANG Y., GUO J. and Chen Z., Closing the door to human immunodeficiency virus, Protein & Cell. 2013, 4: 86-102.
Liu Z., Liu L., Chen Z., Xu M., Zhang T., Jiao Y., Sheng B., Chen D. and Wu H., Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China, Epidemiology and Infection. 2012, 140: 2199-2209.
Qiu M., Chen Y., Song S., Song H., Chu Y., Yuan Z., Cheng L., Zheng D., Chen Z. and Wu Z., Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections – Potential as a dual functional microbicide, Antiviral Research. 2012, 96: 138-147.
Sun C., Chen Z., TANG X., Zhang Y., Feng L., Du Y., xiao L., Liu L., Zhu W. and Chen L., Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys, Journal of Virology. 2013, 87: 5669-5677.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
Wang H., Yao X., Yan P. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., AIDS Vaccine 2012 Conference. 2012.
Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Lau E., Li L., Wu J. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. 2012, 60(3): 328-335.
Yao X., Wang H., yan P.P., Lu Y., Lin H., Chen L., Ng J., Lau E.H.Y., Liu L., Wu J.T.K. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China, Journal of Acquired Immune Deficiency Syndromes. 2012, 60(3): 328-35.
ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.


Researcher : Cheng VCC

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Chen J.H.K., Cheng V.C.C., Chan J.F.W., She K.K.K., Yan M.K. and Yau M.C.Y., The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates, Journal of Microbiological Methods. 2013, 92(2): 99-102.
Cheng V.C.C., To K.K.W., Tse H., Hung I.F.N. and Yuen K.Y., Two Years After Pandemic Influenza A/2009/H1N1: What Have We Learned? , Clinical Microbiology Review. 2012, 25: 223-63.
Ho P.L., Chow K.H., Tse H. and Cheng V.C.C., Effect of applying the new Clinical and Laboratory Standards Institute ticarcillin/clavulanic acid, piperacillin, piperacillin/tazobactam and imipenem susceptibility breakpoints for Pseudomonas aeruginosa in Hong Kong, International journal of antimicrobial agents. Netherlands, Amsterdam : Elsevier Science Publishers, 2012, 40(3): 280-1.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.


Researcher : Cheung CY

Project Title:Mechanism of action for the regulation of COX-2 dependent genes in human macrophages after infection with low and high pathogenic coronavirus and influenza viruses
Investigator(s):Cheung CY, Lee MY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:A comparative study on the role of type I and III interferons in primary human cellular response to influenza virus infection
Investigator(s):Cheung CY
Department:School of Public Health
Source(s) of Funding:Small Project Funding
Start Date:01/2013


Project Title:Biomarkers & Diagnostics World Congress; Diagnosis and assessment of severity in respiratory infectious diseases using host gene expression profiles
Investigator(s):Cheung CY
Department:School of Public Health
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2013




Researcher : Cheung KK

List of Research Outputs

Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.


Researcher : Cho LCK

List of Research Outputs

Tse M.K., Cho L.C.K., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1., Protein Sci.. Wiley, 2012, 21: 1418-1428.


Researcher : Choi KY

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.


Researcher : Choi KY

List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.


Researcher : Chow KH

List of Research Outputs

Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.
Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., Chow K.H., Tse H. and Cheng V.C.C., Effect of applying the new Clinical and Laboratory Standards Institute ticarcillin/clavulanic acid, piperacillin, piperacillin/tazobactam and imipenem susceptibility breakpoints for Pseudomonas aeruginosa in Hong Kong, International journal of antimicrobial agents. Netherlands, Amsterdam : Elsevier Science Publishers, 2012, 40(3): 280-1.
Ho P.L., LI Z., Lo W.U., CHEUNG Y.Y., Lin C., Sham P.C., Ng T.K., Que T.L. and Chow K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China, Emerg Microbes Infect. Shanghai, 2012, 1: 39.
Ho P.L., Chan J., Lo W.U., Law P.Y.T. and Chow K.H., Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig., Veterinary Microbiology. ELSEVIER, 2013, 162(2-4): 964-7.


Researcher : Curreem SOT

List of Research Outputs

To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.


Researcher : Fan YY

List of Research Outputs

Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.


Researcher : Fung CCY

List of Research Outputs

Poon L.L.M., Chan K.H., Chu K.W., Fung C.C.Y., Cheng K.Y., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community. , J Clin Virol. 2012, 52: 146-150.


Researcher : GUO J

List of Research Outputs

KANG Y., GUO J. and Chen Z., Closing the door to human immunodeficiency virus, Protein & Cell. 2013, 4: 86-102.


Researcher : Guan Y

Project Title:Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:04/2002


Project Title:Searching for the precursor of SARS-Cov in Southern China
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:State Key Laboratory of Emerging Infectious Diseases
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:Matching Fund for State Key Laboratory (SKL)
Start Date:02/2009


Project Title:Long-term surveillance for bat-borne viruses: An insight into viral ecology, evolutionary dynamics, and the source of zoonoses
Investigator(s):Guan Y, Dhanasekaran V, Lai ACK, Zhu H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:01/2013




Researcher : Guo F

List of Research Outputs

Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.


Researcher : HO YM

List of Research Outputs

Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.


Researcher : Ho CC

List of Research Outputs

Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.


Researcher : Ho PL

Project Title:A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):Ho PL, Yuen KY, Que TL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


Project Title:Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):Ho PL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2001


Project Title:Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):Ho PL, Hung CT
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):Ho PL, Wong SSY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2006


List of Research Outputs

Chan K.H., To K.K.W., Chan B.W., Li C.P., Chiu S.S.S., Yuen K.Y. and Ho P.L., Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens., Journal of Clinical Microbiology . 2013, 51: 2592-2598.
Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Ho P.L., BMC Infectious Diseases, Section Editor 2013-, 2013.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.
Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., Chow K.H., Tse H. and Cheng V.C.C., Effect of applying the new Clinical and Laboratory Standards Institute ticarcillin/clavulanic acid, piperacillin, piperacillin/tazobactam and imipenem susceptibility breakpoints for Pseudomonas aeruginosa in Hong Kong, International journal of antimicrobial agents. Netherlands, Amsterdam : Elsevier Science Publishers, 2012, 40(3): 280-1.
Ho P.L., LI Z., Lo W.U., CHEUNG Y.Y., Lin C., Sham P.C., Ng T.K., Que T.L. and Chow K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China, Emerg Microbes Infect. Shanghai, 2012, 1: 39.
Ho P.L., Chan J., Lo W.U., Law P.Y.T. and Chow K.H., Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig., Veterinary Microbiology. ELSEVIER, 2013, 162(2-4): 964-7.
Livermore D.M., Andrews J.M., Hawkey P.M., Ho P.L., Keness Y., Doi Y., Paterson D. and Wooddord N., Are susceptibility tests enough, or should laboratories still seek ESBLs and carbapenemases directly?, The Journal of antimicrobial chemotherapy. England, London, New York, Academic Press, 2012, 67(7): 1569-1577.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Wun Y.T., Lam T.P., Lam K.F., Ho P.L. and Yung W.H., The public's perspectives on antibiotic resistance and abuse among Chinese in Hong Kong., Pharmacoepidemiology and Drug Safety. 2013, 22: 241-249.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.


Researcher : Hui PY

Project Title:Role of retinoic acid inducible gene-1, toll-like receptor-3 and -8 in cytokine induction by influenza A H5N1 and pandemic H1N1 viruses in primary human cells
Investigator(s):Hui PY, Peiris JSM, Cheung CY, Chan MCW, Lee MY, Chan WY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2010


Project Title:Role of focal adhesion kinase in cytokine production by influenza A H5N1 infection
Investigator(s):Hui PY, Peiris JSM
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:08/2012


Project Title:Mechanistic study on the suppression of IL-1beta during highly pathogenic avian influenza H5N1 infection
Investigator(s):Hui PY, Chan MCW
Department:School of Public Health
Source(s) of Funding:Small Project Funding
Start Date:06/2013




Researcher : Im SWK

Project Title:Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):Im SWK, Yam WC
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003




Researcher : Ip WCT

List of Research Outputs

To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.


Researcher : KANG Y

List of Research Outputs

KANG Y., GUO J. and Chen Z., Closing the door to human immunodeficiency virus, Protein & Cell. 2013, 4: 86-102.
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.


Researcher : KE Y

List of Research Outputs

Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.


Researcher : Kao RYT

Project Title:Mode of action of a lead anti-influenza compound identified by chemical genetics
Investigator(s):Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2006


Project Title:Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies
Investigator(s):Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2007


Project Title:Mechanism of novel antagonists of influenza A nucleoprotein trafficking: A chemical genetics approach
Investigator(s):Kao RYT, Chen H, Yang D, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


List of Research Outputs

Amorim M.J., Kao R.Y.T. and Digard P., Nucleozin targets cytoplasmic trafficking of vRNP-Rab11 complexes in influenza A virus infection, Journal of Virology. 2013, 87: 4694-4730.
Choi C.K., Ho D.N.Y., Hui K.F., Kao R.Y.T. and Chiang A.K.S., High-thoughput Screening of Small Organic Molecules for Activation of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-positive Epithelial Malignancies, 17th Research Postgrduate Symposium, Dec 12-13, 2012. 68.
Ho D.N.Y., Hui K.F., Kao R.Y.T. and Chiang A.K.S., High-thoughput Screening of Small Organic Molecules for Activation of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-positive Epithelial Maglignancies, 17th Research Postgraduate Symposium, Dec 12 & 13, 2012. 2012.
LI T.L., Yeung K.W.K., Cheung K.M.C. and Kao R.Y.T., Antibacterial properties of novel ID nanostructured ZnO nanowire coatings on medical grade 316L stainless steel surfaces. 2013.
SUN Y., Leung Y.L., TSUI Y.K., Masuda K., Kao R.Y.T., Chan D. and Cheung K.M.C., First prize for poster section: Screen of Small Molecule Compounds for Intervertebral Disc Degeneration by Chemical Genetics., East meets West Symposium, Shenzhen, China, April 8-9, 2013. 2013.
SUN Y., Leung Y.L., TSUI Y.K., Masuda K., Kao R.Y.T., Chan D. and Cheung K.M.C., Uncovering Small Chemical Molecules for Treatment of Intervertebral Disc Degeneration, Global Spine Congress, 4-6 Apr 2013, Hong Kong. 2013.
TONG W.Y.T., Yeung K.W.K., Cheung K.M.C. and Kao R.Y.T., The development of bio-mimetic materials for tissue reconstruction through the systemtic study of cell-matrix interactions. 2013.
Yeung K.W.K., Wu S., Zhao Y., Liu X., Kao R.Y.T., Luk K.D.K., Cheung K.M.C. and Chu P.K., Antimicrobial effects of oxygen plasma modified medical grade Ti-6Al-4V alloy, Vacuum. 2012.


Researcher : Kwan SWG

List of Research Outputs

Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.


Researcher : LAM TH

List of Research Outputs

LAN Y., Yam W.C., LAM T.H., SIU K.H., Mason A.J. and Lam J.K.W., Investigation of the structural contributions to the antimicrobial peptides activity against Mycobacterium Tuberculosis, Tuberculosis – Can we beat it? The Royal College of Pathologists London, 21 March 2013, UK. 2013.


Researcher : LI C

List of Research Outputs

Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : LI Z

List of Research Outputs

Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., LI Z., Lo W.U., CHEUNG Y.Y., Lin C., Sham P.C., Ng T.K., Que T.L. and Chow K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China, Emerg Microbes Infect. Shanghai, 2012, 1: 39.


Researcher : LU X

List of Research Outputs

ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.


Researcher : Lai ELY

List of Research Outputs

Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.
Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.


Researcher : Lam SF

List of Research Outputs

Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.


Researcher : Lau CY

List of Research Outputs

Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : Lau S.K.P.

Project Title:The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2007


Project Title:Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2010
Completion Date:09/2012


Project Title:Molecular characterization of novel animal bocaviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2010
Completion Date:09/2012


Project Title:Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


Project Title:Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories
Investigator(s):Lau SKP, Woo PCY, Teng LL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013


List of Research Outputs



Researcher : Lau SKP

Project Title:The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2007


Project Title:Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2010
Completion Date:09/2012


Project Title:Molecular characterization of novel animal bocaviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2010
Completion Date:09/2012


Project Title:Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


Project Title:Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories
Investigator(s):Lau SKP, Woo PCY, Teng LL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.
Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.
Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.
Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.
Woo P.C.Y., Lau S.K.P., Li K.S.M., Tsang K.L. and Yuen K.Y., Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronaviruses HKU4 and Pipistrellus bat coronavirus HKU5, Emerging Microbes and Infections. 2012, 1: e35.


Researcher : Lau SY

List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Law PYT

List of Research Outputs

Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.
Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., Chan J., Lo W.U., Law P.Y.T. and Chow K.H., Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig., Veterinary Microbiology. ELSEVIER, 2013, 162(2-4): 964-7.


Researcher : Lee MY

Project Title:Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):Lee MY, Lok S, Cheung CY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:05/2009


Project Title:Host response of the highly pathogenic avian influenza viruses
Investigator(s):Lee MY, Peiris JSM
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:06/2013


Project Title:Cytokines 2012-10th Joint Annual Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research ; PANDEMIC INFLUENZA A H1N1 VIRUSES ELICIT WEAK CYTOKINE RESPONSES IN HUMAN ASTROCYTIC AND NEURONAL CELLS
Investigator(s):Lee MY
Department:School of Public Health
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2012




Researcher : Lee P

List of Research Outputs

Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.


Researcher : Lee RA

List of Research Outputs

To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.


Researcher : Leung ASP

List of Research Outputs

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.


Researcher : Leung SY

List of Research Outputs

Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.


Researcher : Li J

List of Research Outputs

Du L., Jin L., Zhao G., Sun S., Li J., Yu H., Li Y., Zheng B., Liddington R., Zhou Y. and Jiang S., Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on Influenza H5N1 Hemagglutinin., Journal of Virology. 2013, 87(4): 2215-25.
ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.


Researcher : Li KSM

List of Research Outputs

Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Woo P.C.Y., Lau S.K.P., Li K.S.M., Tsang K.L. and Yuen K.Y., Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronaviruses HKU4 and Pipistrellus bat coronavirus HKU5, Emerging Microbes and Infections. 2012, 1: e35.


Researcher : Li PY

List of Research Outputs

Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.


Researcher : Li WS

List of Research Outputs

Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Shea Y.F., Chan J.F.W., Kwok W.C., Hwang Y.Y., Chan T.C., Ni M.Y., Li W.S., Chiu P.K.C., Luk J.K.H. and Chu L.W., Haemophagocytic lymphohistiocytosis: An uncommon clinical presentation of tuberculosis, Hong Kong Medical Journal. 2012, 18(6): 517-25.


Researcher : Liu L

Project Title:Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):Liu L
Department:Medical Faculty
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:09/2009


Project Title:Identification of small molecule HIV-1 inhibitors with distinct new targets
Investigator(s):Liu L
Department:Medical Faculty
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2012


Project Title:The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1
Investigator(s):Liu L, Chen Z
Department:Medical Faculty
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


List of Research Outputs

Yao X., Wang H., yan P.P., Lu Y., Lin H., Chen L., Ng J., Lau E.H.Y., Liu L., Wu J.T.K. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China, Journal of Acquired Immune Deficiency Syndromes. 2012, 60(3): 328-35.


Researcher : Lo WU

Project Title:23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID); Prevalence of IncX plasmid subtypes in Escherichia coli isolates from human and livestock animals/Complete sequence of pIMP-PH114, an IncA/C2 plasmid from Klebsiella pneumoniae carrying blaIMP-4
Investigator(s):Lo WU
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2013


Project Title:Rapid identification of an epidemic clone ST414 of Vancomycin resistant Enterococcus faecium isolates (VREfm) using a novel PCR-based assay
Investigator(s):Lo WU, Ho PL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Ho P.L., Chan J., Lo W.U., Law P.Y.T., LI Z., Lai E.L.Y. and Chow K.H., Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. , Journal of Applied Microbiology. 2013, 114(3): 695-702.
Ho P.L., LI Z., Lo W.U., CHEUNG Y.Y., Lin C., Sham P.C., Ng T.K., Que T.L. and Chow K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China, Emerg Microbes Infect. Shanghai, 2012, 1: 39.
Ho P.L., Chan J., Lo W.U., Law P.Y.T. and Chow K.H., Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig., Veterinary Microbiology. ELSEVIER, 2013, 162(2-4): 964-7.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.


Researcher : Ma SK

List of Research Outputs

PERERA K.V.H., Wickramasinghe G., Cheung C.Y., Nishiura H., Smith D.K., Poon L.L.M., Perera A.K.C., Ma S.K., Sunil-Chandra N.P., Guan Y. and Peiris J.S.M., Swine influenza in Sri Lanka, Emerging Infectious Diseases. 2013, 19(3): 481-4.


Researcher : Mok BWY

Project Title:Exploring the role of influenza A virus NS1 protein in microRNA-induced silencing complex (miRISC) regulation of gene expression
Investigator(s):Mok BWY, Chen H
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:04/2012
Completion Date:09/2013


List of Research Outputs

Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Mok KY

List of Research Outputs

To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.


Researcher : Ng SP

Project Title:Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):Ng SP, Yam WC
Department:Microbiology
Source(s) of Funding:Environment Protection Department - General Award
Start Date:06/2001




Researcher : Peiris JSM

Project Title:IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):Peiris JSM, Guan Y
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:04/2003


Project Title:Virus-cell interaction and the pathogenesis of SARS
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):Peiris JSM, Guan Y, Lau ASY, Poon LLM
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2003


Project Title:The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:12/2005


Project Title:Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens
Investigator(s):Peiris JSM, Chiu SSS, Cheung CY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:06/2006


Project Title:The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:The Wellcome Trust - General Award
Start Date:01/2007


Project Title:Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Collaborating Project Fund
Start Date:06/2007


Project Title:Control of Pandemic and Inter-pandemic Influenza
Investigator(s):Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL
Department:Microbiology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2008


Project Title:The role of Toll-like receptor 10 (TLR10) as an innate immune sensor for respiratory viral infections
Investigator(s):Peiris JSM, Lee MY, Nicholls JM
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011
Completion Date:12/2012


Project Title:ICAAC 2012; H5N1 Influenza Viruses in Asia and Middle-East: Still a Threat?
Investigator(s):Peiris JSM
Department:School of Public Health
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2012




Researcher : Perera RAPM

List of Research Outputs

Perera R.A.P.M., Tsang P.C.S., Samaranayake L.P., Lee M.P. and Li P., Prevalence of oral mucosal lesions in adults undergoing highly active antiretroviral therapy in Hong Kong., Journal of Investigative Clinical Dentistry . 2012, 3: 208-14.


Researcher : Poon KM

List of Research Outputs

Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Poon LLM

Project Title:Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):Poon LLM, Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):Poon LLM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2003


Project Title:Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):Poon LLM
Department:Microbiology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2008


Project Title:Retrospective studies of pandemic and seasonal human influenza viral polymerase complexes
Investigator(s):Poon LLM
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2011


Project Title:Epigenomic modifications induced by influenza A infection
Investigator(s):Poon LLM, Li OTW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:Generation of live attenuated influenza viruses of vaccine potential by using codon usage bias
Investigator(s):Poon LLM
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2013




Researcher : Poon RWS

List of Research Outputs

Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.


Researcher : Que TL

List of Research Outputs

Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.


Researcher : SIU KH

List of Research Outputs

LAN Y., Yam W.C., LAM T.H., SIU K.H., Mason A.J. and Lam J.K.W., Investigation of the structural contributions to the antimicrobial peptides activity against Mycobacterium Tuberculosis, Tuberculosis – Can we beat it? The Royal College of Pathologists London, 21 March 2013, UK. 2013.


Researcher : She KKK

List of Research Outputs

Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Chen J.H.K., Cheng V.C.C., Chan J.F.W., She K.K.K., Yan M.K. and Yau M.C.Y., The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates, Journal of Microbiological Methods. 2013, 92(2): 99-102.


Researcher : Siu GKH

List of Research Outputs

Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L., Jumagulova E., Kozlowska J., Patel J., McIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K.W., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and anti-bacterial, -plasmodium, - and –cancer potency of cationic α-helical peptides, The Journal of Biological Chemistry. 2012, 271: 34120-34133.
Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L.J., Kanno T., Jumagulova E., Kozlowska J., Patel J., MCIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides, J Biol Chem. 2012, 287: 34120-34133.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.
Yam W.C. and Siu G.K.H., Rapid identification of mycobacteria and rapid detection of drug resistance in Mycobacterium tuberculosis in cultured isolates and in respiratory specimens, Methods in Molecular Biology. 2013, 943: 171-199.


Researcher : Smith GJ

Project Title:Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:05/2007


Project Title:Outstanding Young Researcher Award 2008-2009
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2009


List of Research Outputs

Lessler J., Riley S., Read J.M., Wang S., Zhu H., Smith G.J., Guan Y., Jiang C. and Cummings D.A.T., Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China, PLoS Pathogens. 2012, 8: e1002802.


Researcher : Song W

List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Srivastava V

Project Title:Identification of ADCC Epitope(s) on HIV Envelop Glycoprotein
Investigator(s):Srivastava V, Zhang M
Department:Medical Faculty
Source(s) of Funding:Small Project Funding
Start Date:04/2012
Completion Date:02/2013


List of Research Outputs

Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.


Researcher : Sze KH

Project Title:XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):Sze KH
Department:Chemistry
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2006


Project Title:Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogen’s evasion of host defense?
Investigator(s):Sze KH, Yuen KY, Kao RYT, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogens evasion of host defense?
Investigator(s):Sze KH, Kao RYT, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:Structure-function study of virulence factor Macrophage Infectivity Potentiator of Coxiella burnetii and Legionella pneumophila
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:18th International Society of Magnetic Resonance Meeting & WeNMR Workshop; INSIGHTS INTO UBIQUITIN C-TERMINAL HYDROLASE L1 (UCH-L1) MUTATION’S ASSOCIATION WITH THE RISK OF PARKINSON'S DISEASE
Investigator(s):Sze KH
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2013


List of Research Outputs

Sze K.H., TSE M.K., CHO C.K.L., WONG W.F., HUI S.K. and Sun H., Domain organization of XAF1 and the identification and characterization of XIAORING-binding domain of XAF1, 6th Asian Biological Inorganic Chemistry . 2012.
TSE M.K., CHO C.K.L., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAORING-binding domain of XAF1, 6th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.
Tse M.K., Cho L.C.K., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1., Protein Sci.. Wiley, 2012, 21: 1418-1428.


Researcher : TAN Z

List of Research Outputs

Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. .
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.


Researcher : TANG X

List of Research Outputs

Sun C., Chen Z., TANG X., Zhang Y., Feng L., Du Y., xiao L., Liu L., Zhu W. and Chen L., Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys, Journal of Virology. 2013, 87: 5669-5677.


Researcher : Tai H

List of Research Outputs

Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Tam WT

List of Research Outputs

Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.


Researcher : Teng LL

Project Title:Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2006


Project Title:Automated identification of medically important bacteria by 16S rRNA sequencing using a novel comprehensive database 16SpathDB
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:09/2011
Completion Date:08/2012


Project Title:Usefulness of full sequence and 5’ end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-negative bacteria
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:09/2011
Completion Date:08/2012


Project Title:The complete genome sequencing of Tsukamurella tyrosinosolvens, a bacterium associated with ophthalmologic infections
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.
To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.


Researcher : To KKW

Project Title:Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):To KKW, Ho PL, Chan KH, Hung IFN, Chiu SSS
Department:Microbiology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:07/2011


Project Title:13th Asia-Pacific Congress of Clinical Microbiology and Infection; The Use of Real-Time Quantitative Polymerase Chain Reaction in Nasopharyngeal Aspirate Specimens for the Diagnosis of Pneumocystis Pneumonia in An Area with Low Prevalence of HIV
Investigator(s):To KKW
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Chan K.H., To K.K.W., Chan B.W., Li C.P., Chiu S.S.S., Yuen K.Y. and Ho P.L., Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens., Journal of Clinical Microbiology . 2013, 51: 2592-2598.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Cheng V.C.C., To K.K.W., Tse H., Hung I.F.N. and Yuen K.Y., Two Years After Pandemic Influenza A/2009/H1N1: What Have We Learned? , Clinical Microbiology Review. 2012, 25: 223-63.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.
To K.K.W., Zhang J., Hung I.F.N. and Yuen K.Y., High Titer And Avidity Of Nonneutralizing Antibodies Against Influenza Vaccine Antigen Are Associated With Severe Influenza., Clin Vaccine Immunol . 2012, 19(7):1012-8.
To K.K.W., Immune Dysregulation in Severe Influenza, Merck Millipore research forum. 2013.
To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Yap Y.H.D., Kwan L.P., To K.K.W. and Chan D.T.M., Arcobacter peritonitis after fluoroscopic repositioning of a Tenckhoff catheter, Peritoneal Dialysis International. 2013, 33(2): 222-3.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : To WCS

List of Research Outputs

To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., TSANG O.T. and Yam W.C., HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?, Int J STD AIDS. 2013.


Researcher : Tong HL

List of Research Outputs

Chan K.H., Chan K.M., Ho Y.L., Lam Y.P., Tong H.L., Poon L.L.M., Cowling B.J. and Peiris J.S.M., Quantitative analysis of four rapid antigen assays for detection of pandemic H1N1 2009 compared with seasonal H1N1 and H3N2 influenza A viruses on nasopharyngeal aspirates from patients with influenza, Journal of Virological Methods. 2012, 186(1-2): 184-8.


Researcher : Tsang CC

List of Research Outputs

To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.
Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.


Researcher : Tsang KL

List of Research Outputs

Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Wang Q., Li B., Tsang K.L., Yi Y., Woo P.C.Y. and Liu C.H., Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates., PLoS One. 2013, 8: e57091.
Woo P.C.Y., Lau S.K.P., Li K.S.M., Tsang K.L. and Yuen K.Y., Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronaviruses HKU4 and Pipistrellus bat coronavirus HKU5, Emerging Microbes and Infections. 2012, 1: e35.


Researcher : Tse H

Project Title:Purification and characterization of cytotoxins produced by the human pathogen Staphylococcus lugdunensis
Investigator(s):Tse H, Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Phylogenetic reconstruction of coronavirus evolution under non-homogeneous, non-stationary models
Investigator(s):Tse H, Lau SKP, Yuen KY, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:04/2012


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Cheng V.C.C., To K.K.W., Tse H., Hung I.F.N. and Yuen K.Y., Two Years After Pandemic Influenza A/2009/H1N1: What Have We Learned? , Clinical Microbiology Review. 2012, 25: 223-63.
Ho P.L., Chow K.H., Tse H. and Cheng V.C.C., Effect of applying the new Clinical and Laboratory Standards Institute ticarcillin/clavulanic acid, piperacillin, piperacillin/tazobactam and imipenem susceptibility breakpoints for Pseudomonas aeruginosa in Hong Kong, International journal of antimicrobial agents. Netherlands, Amsterdam : Elsevier Science Publishers, 2012, 40(3): 280-1.
To K.K.W., Lo W.U., Chan J.F.W., Tse H., Cheng V.C.C. and Ho P.L., Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity, Int J Infect Dis. Canada, 2013, 17: 120-124.
Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.
Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : Tse MK

List of Research Outputs

Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.
Tse M.K., Cho L.C.K., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1., Protein Sci.. Wiley, 2012, 21: 1418-1428.


Researcher : Tsoi HW

List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.


Researcher : WU H

List of Research Outputs

WU H., Zhang H., ZHANG X., Xu H.F., Wang M., Huang J. and Zheng B., Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro., PLoS One. 2012, 7(9):: e44333.


Researcher : Wang H

Project Title:Induction of gp41-specific IgA to prevent HIV infection.
Investigator(s):Wang H, Chen Z
Department:Medical Faculty
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Wang H., Yao X., Yan P. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., AIDS Vaccine 2012 Conference. 2012.
Yao X., Wang H., yan P.P., Lu Y., Lin H., Chen L., Ng J., Lau E.H.Y., Liu L., Wu J.T.K. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China, Journal of Acquired Immune Deficiency Syndromes. 2012, 60(3): 328-35.


Researcher : Wang P

List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Wong BHL

List of Research Outputs

Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.


Researcher : Wong KH

List of Research Outputs

To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., TSANG O.T. and Yam W.C., HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?, Int J STD AIDS. 2013.


Researcher : Wong SCY

List of Research Outputs

To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.


Researcher : Wong SSY

Project Title:Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):Wong SSY, Yuen KY, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):Wong SSY, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


List of Research Outputs

Wong S.S.Y. and Yuen K.Y., Infections associated with body modification, Journal of the Formosan Medical Association. Taiwan, 2012, 111: 667-681.
Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.


Researcher : Wong TY

List of Research Outputs

Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.


Researcher : Woo P.C.Y.

Project Title:A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2010


Project Title:Molecular evolution and interspecies jumping in picornaviruses
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Significance of Lichtheimia hongkongensis as a cause of mucormycosis
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Molecular epidemiology of Exophiala infections in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013


List of Research Outputs



Researcher : Woo PCY

Project Title:A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2010


Project Title:Molecular evolution and interspecies jumping in picornaviruses
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Significance of Lichtheimia hongkongensis as a cause of mucormycosis
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Molecular epidemiology of Exophiala infections in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Shea Y.F., Chan F.H.W., Woo P.C.Y. and Chu L.W., Functional status of older nursing home residents can affect the efficacy of influenza vaccination. , Journal of Gerontology. 2013, 68: 324-330.
Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.
Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.
To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.
Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Wang Q., Li B., Tsang K.L., Yi Y., Woo P.C.Y. and Liu C.H., Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates., PLoS One. 2013, 8: e57091.
Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.
Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Central Veterinary Research Laboratory (Dubai, UAE). 2013.
Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Southern Medical University (Guangzhou, China). 2013.
Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Universiti Tunku Abdul Rahman (Kampar, Malaysia). 2012.
Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, University of Sharjah (Sharjah, UAE). 2013.
Woo P.C.Y., Coronavirus phylogeny and its impact, Sixth Ditan International Conference on Infectious Diseases (Beijing, China). 2012.
Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.
Woo P.C.Y., Lau S.K.P., Li K.S.M., Tsang K.L. and Yuen K.Y., Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronaviruses HKU4 and Pipistrellus bat coronavirus HKU5, Emerging Microbes and Infections. 2012, 1: e35.
Woo P.C.Y., Section editor (Emerging viruses), Current Opinion in Virology, 2013.


Researcher : Wu AKL

List of Research Outputs

To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.


Researcher : Wu WL

Project Title:Characterization of conserved antigenic epitopes in hemagglutinin (HA) of the pandemic (H1N1) influenza virus with cross subtypes neutralizing monoclonal antibodies
Investigator(s):Wu WL, Chen H
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:08/2012


List of Research Outputs

Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : Xiong L

List of Research Outputs

Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.


Researcher : Xu T

List of Research Outputs

Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.


Researcher : YANG Z

List of Research Outputs

Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.
Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012.


Researcher : YUAN S

List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.


Researcher : YUAN T

List of Research Outputs

ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.
Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012.


Researcher : Yam WC

List of Research Outputs

Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
DHEDA K., RUHWALD M., THERON G., PETER J. and Yam W.C., Point-of-care diagnosis of tuberculosis: past, present and future, Respirology. 2013, 18(2): 217-32.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., HO Y.M., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals. , Journal of Clinical Microbiology. 2012, 50(11): 3735-7.
Ho P.L., Chow K.H., Lai E.L.Y., Law P.Y.T., Chan P.Y., Ho A.Y., Ng T.K. and Yam W.C., Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals, J Clin Microbiol. 2012, 50(11): 3735-7.
Lan Y., Yam W.C., Siu G. and Lam J.K.W., Development of Novel Therapeutics against Tuberculosis, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 132.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Chen Z. and Yam W.C., Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods, AIDS Res Hum Retroviruses. 2013, 29(8): 1123-8.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., TSANG O.T. and Yam W.C., HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?, Int J STD AIDS. 2013.
Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.
Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L., Jumagulova E., Kozlowska J., Patel J., McIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K.W., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and anti-bacterial, -plasmodium, - and –cancer potency of cationic α-helical peptides, The Journal of Biological Chemistry. 2012, 271: 34120-34133.
Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L.J., Kanno T., Jumagulova E., Kozlowska J., Patel J., MCIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides, J Biol Chem. 2012, 287: 34120-34133.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.
Yam W.C. and Siu G.K.H., Rapid identification of mycobacteria and rapid detection of drug resistance in Mycobacterium tuberculosis in cultured isolates and in respiratory specimens, Methods in Molecular Biology. 2013, 943: 171-199.


Researcher : Yang Z

List of Research Outputs

Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.
Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012.


Researcher : Yau MCY

List of Research Outputs

Chen J.H.K., Cheng V.C.C., Chan J.F.W., She K.K.K., Yan M.K. and Yau M.C.Y., The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates, Journal of Microbiological Methods. 2013, 92(2): 99-102.


Researcher : Yen H

Project Title:The role of balanced hemagglutinin-neuraminidase activity on the genesis of transmissible NA inhibitor-resistant variants in seasonal and novel pandemic influenza A H1N1 viruses
Investigator(s):Yen H, Peiris JSM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Role of influenza hemagglutinin glycoprotein in activation of dendritic cells and induction of effective immune response through C-type lectin receptors
Investigator(s):Yen H, Peiris JSM, Tu W
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011
Completion Date:12/2012


Project Title:Evaluating effect of pandemic H1N1 matrix protein 1 on viral replication in vitro
Investigator(s):Yen H, Peiris JSM
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Applying glycan array to determine neuraminidase substrate specificity of pandemic H1N1 and swine H1N1 influenza viruses
Investigator(s):Yen H
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013




Researcher : Yeung ML

Project Title:Identification of Hepatitis B virus (HBV) receptors
Investigator(s):Yeung ML, Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011
Completion Date:11/2012


Project Title:Dissecting the roles of tryptophanyl-tRNA synthetase and other host factors contributory to Enterovirus 71 (EV71) replication
Investigator(s):Yeung ML, Yip CY
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Yeung M.L., Comparative Cytokine Response Between Human Coronaviruses MERS-CoV and SARS-CoV, A Croucher Foundation-Sponsored Conference: Molecular Mechanisms of Innate Immunity 2013. 2013.


Researcher : Yew WW

List of Research Outputs

Leung C.C., Hui L., Lee R.S.Y., Lam T.H., Yew W.W., Hui D.S.C., Chan R.C.Y., Mok Y.W., Law W.S., Chang K.C., Leung E.C.C. and Tam C.M., Tuberculosis is associated with increased lung cancer mortality, International Journal of Tuberculosis and Lung Disease. 2013, 17(5): 687-92.


Researcher : Yip CY

Project Title:Complete genome sequence analysis of human enterovirus 71 strains from 2004 to 2010 in Hong Kong
Investigator(s):Yip CY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:11/2011


List of Research Outputs

Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.


Researcher : Yuan T

List of Research Outputs

ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.
Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012.


Researcher : Yuen K.Y.

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Discovery and characterization of novel microbes with epidemic potential
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:01/2007


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Internal Award for CAE Membership
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Internal Award for Chinese Academy of Engineering Membership
Start Date:02/2008


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Infection and Immunology
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2008


List of Research Outputs



Researcher : Yuen KY

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Discovery and characterization of novel microbes with epidemic potential
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:01/2007


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Internal Award for CAE Membership
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Internal Award for Chinese Academy of Engineering Membership
Start Date:02/2008


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Infection and Immunology
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2008


List of Research Outputs

Chan J.F.W., Chan K.H., Choi K.Y., To K.K.W., Tse H., Cai J., Yeung M.L., Cheng V.C.C., Chen H., Che X.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC): implications for disease pathogenesis and clinical manifestation., Journal of Infectious Diseases. 2013, 207: 1743-1752.
Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H. and Yuen K.Y., Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?, Journal of Infection. 2012, 65: 477-489.
Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chan K.H., To K.K.W., Chan B.W., Li C.P., Chiu S.S.S., Yuen K.Y. and Ho P.L., Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens., Journal of Clinical Microbiology . 2013, 51: 2592-2598.
Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chan K.H., Yan M.K., To K.K.W., Lau S.K.P., Woo P.C.Y., Cheng V.C.C., Li W.S., Chan J.F.W., Tse H. and Yuen K.Y., Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates., Journal of Medical Virology . 2013, 85: 874-879.
Chen J.H.K., Ho P.L., Kwan S.W.G., She K.K.K., Siu G.K.H., Cheng V.C.C., Yuen K.Y. and Yam W.C., Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems, J Clinical Microbiology. 2013, 51(6): 1733-9.
Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Cheng V.C.C., To K.K.W., Tse H., Hung I.F.N. and Yuen K.Y., Two Years After Pandemic Influenza A/2009/H1N1: What Have We Learned? , Clinical Microbiology Review. 2012, 25: 223-63.
Guo F., Xiong L., Teng L.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods., DNA Research. 2013, 20: 273-286.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
Lau S.K.P., Yip C.Y., Lung D.C., Lee P., Que T.L., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Detection of human rhinovirus C in fecal samples of children with gastroenteritis, Journal of Clinical Virology. 2012, 53: 290-296.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.
To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Zhang J., Hung I.F.N. and Yuen K.Y., High Titer And Avidity Of Nonneutralizing Antibodies Against Influenza Vaccine Antigen Are Associated With Severe Influenza., Clin Vaccine Immunol . 2012, 19(7):1012-8.
To K.K.W., Lau S.K.P., Wu A.K.L., Lee R.A., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Yuen K.Y. and Woo P.C.Y., Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and beta-tubulin gene sequencing., Diagnostic Microbiology and Infectious Disease. 2012, 74: 190-197.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Tse H., Chan W.M., Lam S.F., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel rat noroviruses in Hong Kong, Journal of Virology. 2012, 86: 12435-12436.
Tse H., Bao Y., Davies M.R., Maamary P., Tsoi H.W., Tong A.H.Y., Ho C.C., Lin C., Gillen C.M., Barnett T.C., Chen J.H.K., Lee M., Yam W.C., Wong C.K., Ong C.Y., Chan Y.W., Wu C.W., Ng T., Lim W.W.L., Tsang T.H.F., Tse C.W.S., Dougan G., Walker M.J., Lok S. and Yuen K.Y., Molecular characterization of the 2011 Hong Kong scarlet fever outbreak, Journal of Infectious Diseases. 2012, 206: 341-351.
Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.
Tse M.K., Cheung K.K., KE Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain 1H, 13C and 15N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii, Biomolecular NMR Assignments. Netherlands, Springer Netherlands, 2013, N.A.: N.A.
Wong S.S.Y. and Yuen K.Y., Infections associated with body modification, Journal of the Formosan Medical Association. Taiwan, 2012, 111: 667-681.
Woo P.C.Y., Ngan A.H.Y., Tsang C.C., Ling I.W.H., Chan J.F.W., Leung S.Y., Yuen K.Y. and Lau S.K.P., Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis, Journal of Clinical Microbiology . 2013, 51: 260-267.
Woo P.C.Y., Lau S.K.P., Choi K.Y., Yip C.Y., Huang Y., Tsoi H.W. and Yuen K.Y., Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs, Journal of Virology . 2012, 86: 3402-3403.
Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.
Woo P.C.Y., Lau S.K.P., Li K.S.M., Tsang K.L. and Yuen K.Y., Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronaviruses HKU4 and Pipistrellus bat coronavirus HKU5, Emerging Microbes and Infections. 2012, 1: e35.
Xu L., He X., Zhang D.M., Feng F.S., Wang Z., Guan L.L., Wu J., Zhou R., Zheng B., Yuen K.Y., Li M.F. and Cao K.Y., Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China., PLoS One. 2012, 7(9):: e44876.
Yam W.C., Siu G.K.H., Ho P.L., NG T.K., Que T.L., Yip K.T., FOK C.P., Chen J.H.K., Cheng V.C.C. and Yuen K.Y., Evaluation Of The Lightcycler Methicillin-resistant Staphylococcus Aureus (mrsa) Advanced Test For Detection Of Mrsa Nasal Colonication, Journal of Clinical Microbiology. 2013, 51(9): 2869-74.
ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : ZHANG K

List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.


Researcher : ZHANG X

List of Research Outputs

WU H., Zhang H., ZHANG X., Xu H.F., Wang M., Huang J. and Zheng B., Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro., PLoS One. 2012, 7(9):: e44333.


Researcher : ZHANG Y

List of Research Outputs

ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.


Researcher : ZHENG M

List of Research Outputs

Chen Y., Liang W.F., Yang S.G., Wu N.P., Gao H.N., Sheng J.F., Yao H.P., Wo J.N., Fang Q., Cui D.W., Li Y.C., Yao X., Zhang Y.T., Wu H.B., Zheng S.F., Diao H.Y., Xia S.C., Zhang Y.J., Chan K.H., Tsoi H.W., Teng L.L., Song W., Wang P., Lau S.Y., ZHENG M., Chan J.F.W., To K.K.W., Chen H., Li L.J. and Yuen K.Y., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, The Lancet. 2013, 381: 1916-1925.
Mok B.W.Y., Song W., Wang P., Tai H., Chen Y., Zheng M., Wen X., Lau S.Y., Wu W.L., Matsumoto K., Yuen K.Y. and Chen H., The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection., Journal of Virology. USA, Journal fof Virology, 2012, 86(23): 12695-12707.


Researcher : ZHOU J

List of Research Outputs

Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. .
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : Zhang H

Project Title:A pilot study for the role of TH17 in chronic hepatitis B patients
Investigator(s):Zhang H, Zheng B
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):Zhang H
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2011




Researcher : Zhang H

List of Research Outputs

WU H., Zhang H., ZHANG X., Xu H.F., Wang M., Huang J. and Zheng B., Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro., PLoS One. 2012, 7(9):: e44333.


Researcher : Zhang J

Project Title:Mechanisms study of 2009 pandemic H1N1 influenza causes severe infection in obese Mice
Investigator(s):Zhang J, Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:09/2011
Completion Date:09/2012


Project Title:Imiquimod accelarets protective immune responses induced by inactivated influenza vaccine in BALB/c mice
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2012


List of Research Outputs

Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
To K.K.W., Zhang J., Hung I.F.N. and Yuen K.Y., High Titer And Avidity Of Nonneutralizing Antibodies Against Influenza Vaccine Antigen Are Associated With Severe Influenza., Clin Vaccine Immunol . 2012, 19(7):1012-8.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Zhang JX

Project Title:Mechanisms study of 2009 pandemic H1N1 influenza causes severe infection in obese Mice
Investigator(s):Zhang J, Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:09/2011
Completion Date:09/2012


Project Title:Imiquimod accelarets protective immune responses induced by inactivated influenza vaccine in BALB/c mice
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2012


List of Research Outputs



Researcher : Zhang M

Project Title:Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals
Investigator(s):Zhang M
Department:Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:08/2011


Project Title:Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2011


Project Title:Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):Zhang M, Srivastava V, Li J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:11/2011
Completion Date:04/2013


Project Title:Development of intrabodies targeting eukaryotic translation initiation factor 5A2 for cancer treatment
Investigator(s):Zhang M, Guan X
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:06/2012


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Guiding the immune response: a novel approach for HIV-1 vaccine development
Investigator(s):Zhang M
Department:Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Keystone Symposium--B Cell Development and Function; Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2013
Completion Date:02/2013


List of Research Outputs

Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.
ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.
Zhang M., Anti-IGF-IR monoclonal antibodies and uses thereof, US patent 8,444,982. 2013.
Zhang M., From Antibodies to Antibody-based Drugs and Vaccine Immunogens, Fudan University. 2012.
Zhang M., Yuan T., Li J., Rosa Borges A., Watkins J., Guenaga J., Yang Z., Wang Y., Wilson R., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody that Binds to Both gp120 and gp41 , PLoS One. 2012.
Zhang M., Limitations of the Human Immune System in Developing Broadly HIV-1-neutralizing Antibodies, China AIDS Vaccine Initiative (CAVI) Annual meeting, Tsinghua University, Beijing, China. 2012.
Zhang M., Maturation of Germline Antibodies to Broadly Neutralizing Antibodies, Hong Kong Symposium on HIV/AIDS 2012. Hong Kong, China. 2012.


Researcher : Zhang Y

List of Research Outputs

ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., Limitations of human immune system in developing broadly HIV-1-neutralizing antibodies, Keystone Symposia on B Cell Development and Function. 2013.


Researcher : Zheng B

Project Title:CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):Zheng B, Lu L, Chan KW
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:07/2006


Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2007


Project Title:Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2009


Project Title:Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY, Jin D
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2011


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Stem Cell Regulation in Homeostasis and Disease (B7); Identification and Characterization of Tumorigenic Liver Cancer Stem Cells
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2013


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:03/2013


List of Research Outputs

Chan K.H., Chan J.F.W., Tse H., Chen H., Lau C.Y., Cai J., Tsang K.L., Xiao X., To K.K.W., Lau S.K.P., Woo P.C.Y., Zheng B., Wang M. and Yuen K.Y., Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests, Journal of Infection . 2013, 67: 130-140.
Chen Y., Hwang S.Y., Chan V.S.F., Chung P.Y., Wang S.R., Li Z., Ma J., Lin C.W., Hsieh Y.J., Chang K.P., Kung S.S., Wu Y.C., Chu C.W., Tai H.T., Gao G.F., Zheng B., Yokoyama K.K., Austyn J.M. and Lin C.L., Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells, PLoS Pathogen. 2013, 9(1): e1003100.
Du L., Jin L., Zhao G., Sun S., Li J., Yu H., Li Y., Zheng B., Liddington R., Zhou Y. and Jiang S., Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on Influenza H5N1 Hemagglutinin., Journal of Virology. 2013, 87(4): 2215-25.
Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.
Lau S.K.P., Li K.S.M., Tsang K.L., Shek C.T., Wang M., Choi K.Y., Guo R., Wong B.H.L., Poon R.W.S., Lam S.F., Wang S.Y.H., Fan Y.Y., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders., Journal of Virology. 2012, 86: 11906-11918.
Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.
Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.
WU H., Zhang H., ZHANG X., Xu H.F., Wang M., Huang J. and Zheng B., Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro., PLoS One. 2012, 7(9):: e44333.
Xu L., He X., Zhang D.M., Feng F.S., Wang Z., Guan L.L., Wu J., Zhou R., Zheng B., Yuen K.Y., Li M.F. and Cao K.Y., Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China., PLoS One. 2012, 7(9):: e44876.
ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


Researcher : Zheng B.

Project Title:CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):Zheng B, Lu L, Chan KW
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:07/2006


Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2007


Project Title:Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2009


Project Title:Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY, Jin D
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2011


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Stem Cell Regulation in Homeostasis and Disease (B7); Identification and Characterization of Tumorigenic Liver Cancer Stem Cells
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2013


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:03/2013


List of Research Outputs



Researcher : Zhou J

Project Title:A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif
Investigator(s):Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif
Investigator(s):Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2011


Project Title:Characterization of KLF15 as a crucial transactivator for hepatitis B virus gene expression and viral replication in vitro and in vivo
Investigator(s):Zhou J, Yuen KY, Zheng B
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Exploring the role of CD55 in the pathogenesis of influenza virus A infection
Investigator(s):Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


List of Research Outputs

Cheung K.L.A., ZHOU J., Liu H., TAN Z. and Chen Z., A novel programmed death 1 isoform-based fusion DNA vaccine enhances functional antigen-specific CD8+ T cell immunity (P4499), IMMUNOLOGY 2013. .
ZHOU J., Cheung K.L.A., TAN Z., Wang H., Yu W., Du Y., KANG Y., LU X., Liu L., Yuen K.Y. and Chen Z., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation. 2013, 123: 2629-2642.
Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.


-- End of Listing --