DEPT OF CLINICAL ONCOLOGY



Researcher : Au GKH
List of Research Outputs

Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.
Lee V.H.F., Ng S.C., Leung T.W., Au G.K.H. and Kwong D.L.W., Dosimetric Predictors of Radiation-induced Acute Nausea and Vomiting in IMRT for Nasopharyngeal Cancer, International Journal of Radiation Oncology • Biology • Physics. Elsevier Inc., 2012, 84(1): 176-182.


Researcher : CAO T
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.


Researcher : CHAN KH
List of Research Outputs

CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Accuracy and sensitivity of four-dimensional dose calculation to systematic motion variability in stereotatic body radiotherapy (SBRT) for lung cancer, Journal of Applied Clinical Medical Physics. 2012, 13(6): 3992.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Experimental evaluations of the accuracy of 3D and 4D planning in robotic tracking stereotactic body radiotherapy for lung cancers, Medical Physics. 2013, 40(4): 041712.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tam E.K. and Tong A.S., Investigation of four-dimensional (4D) Monte Carlo dose calculation in real-time tumor tracking stereotatic body radiotherapy for lung cancers, Medical Physics . 2012, 39(9): 5479-87.


Researcher : CHEN J
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
Li Y., ZHU C., Nie C.J., Li J.C., Zeng T.T., Zhou J., CHEN J., Chen K., Liu H., Qin Y.R. and Guan X., Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma., PLoS One . 2013, 8: e60027.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Chai S
List of Research Outputs

Chai S. and Ma S.K.Y., Clinical implications of miRNA in liver cancer stem cells, Chin J Cancer. 2013, 2013.


Researcher : Chan HM
List of Research Outputs

Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.


Researcher : Chan OSH
List of Research Outputs

Lee A.W.M., Ng W.T., Chan L.K., Chan O.S.H., Hung W.M., Chan C.C., Cheng P.T., Sze C.K.H., Lam T.S. and Yau T.K., The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement, Oral Oncol. 2012, 48: 1007-13.


Researcher : Chen J
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
Li Y., ZHU C., Nie C.J., Li J.C., Zeng T.T., Zhou J., CHEN J., Chen K., Liu H., Qin Y.R. and Guan X., Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma., PLoS One . 2013, 8: e60027.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Chen L
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Dai Y.D., Liu L.L., Zeng T.T., Zhu Y.H., Li J.C., Chen L., Li Y., Yuan Y.F., Ma S.K.Y. and Guan X., Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma, Biochem Biophys Res Commun. 2013, 2013.
Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.
LI J., Lau G., Chen L., Yuan Y.F., Huang J., Luk J.M.C., Xie D. and Guan X., Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression, PLoS One. 2012, 7(9): e46264.
Zhu Y., Fu L., Chen L., Qin Y.R., Liu H., Xie F.J., Zeng T.T., LI J., Li Y., Dai Y., Xie D. and Guan X., Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2013, 73: 2298-2309.


Researcher : Cheng Y
Project Title:Reprogramming of nasopharyngeal carcinoma cells by genetic correction after chromosome transfer
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2010
Completion Date:07/2012


Project Title:Wnt-signaling defines cancer stem cells and epithelial-mesenchymal transition
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2012


Project Title:A novel tumor suppressive pathway mediated by BLU gene in nasopharyngeal carcinoma
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


List of Research Outputs

Cheng Y., Book, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 221 pages.
Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers for stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1. , The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers from stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1, The 6th International Nasopharyngeal Carcinoma Symposium . Istanbul, Ea Organization, 2013, O-31.
Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.
Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of Candidate Epigenetic Markers for Early Detection of Nasopharyngeal Carcinoma, American Association for Cancer Research Annual Meeting 2013. Washington DC, AACR, Abstract# 3555.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of candidate epigenetic markers for early detection of nasopharyngeal carcinoma. , 2013.


Researcher : Cheung AKL
Project Title:Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:6th International Symposium on Nasopharyngeal Carcinoma; Protein tyrosine phosphatase receptor type G regulates Akt- and β-catenin-associated epithelial-mesenchymal transition in nasopharyngeal carcinoma
Investigator(s):Cheung AKL
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Cheung A.K.L. and Lung M.L., Protein tyrosine phosphatase receptor type G regulates Akt- and β-catenin-associated epithelial-mesenchymal transition in nasopharyngeal carcinoma, The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.


Researcher : Chiu PM
List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.


Researcher : Chow KK
List of Research Outputs

Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.


Researcher : Choy TS
List of Research Outputs

Lee V.H.F., Choy T.S., Lam K.O., Kwong D.L.W. and Leung T.W., Predictors Of Treatment Outcome In Patients Treated With Radical Chemoradiotherapy For Stage Iii Non-small Cell Lung Cancer, Proffered Session, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.


Researcher : Chua DTT
Project Title:2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2000


Project Title:2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2003


Project Title:46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2004


Project Title:Nasopharyngeal Carcinoma (NPC)
Investigator(s):Chua DTT, Nicholls JM
Department:Clinical Oncology
Source(s) of Funding:Croucher Foundation - Research Grants
Start Date:01/2007


List of Research Outputs

Ng E.K.O., Li R., Shin V.Y., Jin H.C., Leung P.H.C., Ma E.S.K., Pang R.W.C., Chua D.T.T., Chu K.M., Law W.L., Law S.Y.K., Poon R.T.P. and Kwong A., Circulating microRNAs as specific biomarkers for breast cancer detection, PLoS One. 2013, 8(1): e53141.


Researcher : Dong S
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Fu L
Project Title:Characterization of a novel tumor susceptibility gene PSCA in esophageal squamous cell carcinoma
Investigator(s):Fu L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011
Completion Date:12/2012


Project Title:Epigenetic Alteration of Organic Cation Transporter Gene SLC22A3 Confers Susceptibility To Esophageal Cancer in The High-Risk Northern Chinese
Investigator(s):Fu L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.
Zhu Y., Fu L., Chen L., Qin Y.R., Liu H., Xie F.J., Zeng T.T., LI J., Li Y., Dai Y., Xie D. and Guan X., Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2013, 73: 2298-2309.


Researcher : Fung TM
List of Research Outputs

Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.


Researcher : Guan X
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:AACR Annual Meeting 2013; Characterization of a novel oncogene SPOCK1 in human hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Dai Y.D., Liu L.L., Zeng T.T., Zhu Y.H., Li J.C., Chen L., Li Y., Yuan Y.F., Ma S.K.Y. and Guan X., Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma, Biochem Biophys Res Commun. 2013, 2013.
Deng W., Tsao G.S.W., Guan X. and Cheung A., Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells., PLoS ONE. 2012, 7(10): e48576.
Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.
Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.
LI J., Lau G., Chen L., Yuan Y.F., Huang J., Luk J.M.C., Xie D. and Guan X., Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression, PLoS One. 2012, 7(9): e46264.
Li Y., ZHU C., Nie C.J., Li J.C., Zeng T.T., Zhou J., CHEN J., Chen K., Liu H., Qin Y.R. and Guan X., Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma., PLoS One . 2013, 8: e60027.
Liu X., Cheng Q., Geng W., Ling C., Liu Y., Ng K.T.P., Yam J.W.P., Guan X., Lo C.M. and Man K., Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model, Artificial Cells, Nanomedicine, and Biotechnology. 2013, Epub on 2013-06-25.
Lu S., Lu L.Y., Liu M., Yuan Q.J., Sham M.H., Guan X. and Huang J., PDSS2 requirements for cerebellar development and functions, Seventh Conference of the International Coenzyme Q10 Association. 2012.
TONG M., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - Stem Cells and Cancer 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Lok S., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - "Stem Cells & Cancer". 2013.
Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
Wong A.M.G., Tsang J.W.H. and Guan X., Reply to profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2012, 118(8): 4634-4635.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.
Zhu Y., Fu L., Chen L., Qin Y.R., Liu H., Xie F.J., Zeng T.T., LI J., Li Y., Dai Y., Xie D. and Guan X., Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2013, 73: 2298-2309.


Researcher : Guan X.
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:AACR Annual Meeting 2013; Characterization of a novel oncogene SPOCK1 in human hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


List of Research Outputs



Researcher : Guan XY
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:AACR Annual Meeting 2013; Characterization of a novel oncogene SPOCK1 in human hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


List of Research Outputs



Researcher : HU Q
List of Research Outputs

Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.


Researcher : Hu L
List of Research Outputs

Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.


Researcher : Huang Z
List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.


Researcher : KONG KL
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Kan PQR
List of Research Outputs

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.


Researcher : Ko JMY
Project Title:A multigenic SNP association study of DNA repair genes on Chinese esophageal squamous cell carcinoma risk in moderate (Hong Kong) and high risk (Henan) regions
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:05/2012


List of Research Outputs

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.
Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.


Researcher : Kong KL
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Kwan PS
List of Research Outputs

Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.


Researcher : Kwong DLW
Project Title:PET/CT scan for early response monitoring and radiation dose escalation in locally advanced nasopharyngeal carcinoma
Investigator(s):Kwong DLW, Khong PL, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012


List of Research Outputs

CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Accuracy and sensitivity of four-dimensional dose calculation to systematic motion variability in stereotatic body radiotherapy (SBRT) for lung cancer, Journal of Applied Clinical Medical Physics. 2012, 13(6): 3992.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Experimental evaluations of the accuracy of 3D and 4D planning in robotic tracking stereotactic body radiotherapy for lung cancers, Medical Physics. 2013, 40(4): 041712.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tam E.K. and Tong A.S., Investigation of four-dimensional (4D) Monte Carlo dose calculation in real-time tumor tracking stereotatic body radiotherapy for lung cancers, Medical Physics . 2012, 39(9): 5479-87.
CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Cheng S.C., Ying M.T., Kwong D.L.W. and Wu V.W., Sonographic appearance of submandibular glands in patients treated with external beam radiotherapy for nasopharyngeal carcinoma. Cheng SC, Ying MT, Kwong DL, Wu VW. J Clin Ultrasound, Journal of Clinical Ultrasound. 2012, Epub ahead of print.
Huang B., Khong P.L., Whitcher B., Kwong D.L.W., Wong C.S. and Chan Q., Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for characterizing nasopharyngeal carcinoma (NPC): comparison of semi-quantitative and quantitative parameters and correlation with tumor stage, 98th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), Chicago, Illinois, USA, 25-30 November 2012.
Huang B., Wong C.S., Whitcher B., Kwong D.L.W., Lai V., Chan Q. and Khong P.L., Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage, European Radiology. 2013, 23(6): 1495-1502.
Huang B., Wong C.S., Kwong D.L.W., Whitcher B., Chan Q., Lai V. and Khong P.L., Dynamic contrast-enhanced magnetic resonance imaging for characterizing nasopharyngeal carcinoma: comparison of semi-quantitative, quantitative parameters and correlation with tumor stage, CSMRM & OCSMRM Joint Meeting 2012 and ISMRM Int’l Outreach Workshop, Xiamen, China, 14-16 December 2012.
Huang B., Chan T., Kwong D.L.W., Chan K.S. and Khong P.L., Nasopharyngeal carcinoma: Investigation of Intratumoral Heterogeneity with FDG PET/CT, American Journal of Roentgenology . 2012, 199: 169-174.
Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.
Kwok H., Tong A.H.Y., Lin C., Lok S., Farrell P.J., Kwong D.L.W. and Chiang A.K.S., Genomic Sequencing and Comparative Analysis of Epstein-Barr Virus Genome Isolated from Primary Nasopharyngeal Carcinoma Biopsy, 17th Research Postgradute Symposium, Dec 12 & 13, 2012. 2012.
Kwok H., Tong A.H.Y., Lin C., Lok S., Ferrell P.J., Kwong D.L.W. and Chiang A.K.S., Genomic Sequencing and Comparative Analysis of Epstein-Barr Virus Genome Isolated from Primary Nasopharyngeal Carcinoma Biopsy, 17th Research Postgrduate Symposium, Dec 12-13, 2012. 167.
Kwok H., Tong A.H.Y., Lin C., Lok S., Farrell P.J., Kwong D.L.W. and Chiang A.K.S., Genomic Sequencing and Comparative Analysis of Esptein-Barr Virus Genome Isolated from Primary Nasopharyngeal Carcinoma Biopsy, 19th Hong Kong International Cancer Congress - 8-9 Nov 2012, Hong Kong. 2012.
Kwong D.L.W., Advances in the treatment of head & neck cancer, Post-graduate diplopma in diagnosis and therapeutics in internal medicine - CPD lecture. 2012.
Kwong D.L.W., General Research Fund (GRF) 2012-13: HKU 768312M. Amount: HK$ 1,169,000, General Research Fund (GRF). 2012.
Kwong D.L.W., Intensity modulated radiotherapy for nasopharyngeal carcinoma, Hong Kong International Cancer Congress (HKICC), 8-9 November 2012. 2012.
Kwong D.L.W., Latest update on treatment of esophageal cancer, Multi-specialty Medical Mega Conference Third Round (M3C 3.0), 13-14 April 2013, Hong Kong. 2013.
Kwong D.L.W., Management of NPC in Hong Kong, Clinical Oncology Forum: Canadian and Hong Kong Experience. 2013.
Kwong D.L.W., Multimodal treatment for gastric cancer, Hong Kong Surgical Forum. 2012.
Kwong D.L.W., Radiotherapy and Chemotherapy for Head and Neck Cancers, Continuous Nursing Education Programme, Tung Wah Hospital, Hong Kong. 2013.
Kwong D.L.W., Radiotherapy for paediatric cancer patients in China: a brief overview of current situation, International Atomic Energy Agency (IAEA) Technical Meeting on the Development of Standards on Paediatric Radiation Oncology for Low-income Countries, 18-21 June 2013, Vienna, Austria. China representative. . 2013.
Kwong D.L.W., The effect of chemotherapy and radiotherapy on fertility, Hong Kong J Radiol. 2012. Hong Kong, Hong Kong College of Radiologists, 2012, 15(3): 136-42.
Kwong D.L.W., Update on neoadjuvant and adjuvant treatment for gastric cancer, Gastric Cancer Symposium. 2013.
LAU H.Y., Liang J., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and asopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13: 298.
LAU H.Y., Leung C.M., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13(1): 13:298.
LI J., Pow E.H.N., Zheng L., Ma L., Cheung L.K. and Kwong D.L.W., Dose-dependent effect of radiation on titanium implants: a quantitative study in rabbits., Clin Oral Implants Res. 2013.
LI J., Pow E.H.N., Zheng L., Ma L., Cheung L.K. and Kwong D.L.W., Quantitative analysis of titanium-induced artifacts and correlated factors during micro-CT scanning., Clin Oral Implants Res. 2013.
Lam K.O., Lee V.H.F., Liu R.K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab-containing regimens after cetuximab failure in Kras wild-type metastatic colorectal carcinoma, Oncology Letters. Spandidos Publications Ltd, 2013, 5: 637-640.
Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lam K.O., Lau K.S., Ho P.Y., Lee V.H.F., Choy T.S., Liu R.K.Y., Kwong D.L.W. and Leung T.W., Safety and efficacy of cetuximab-XELOX combination in the first-line treatment of Kras wild-type metastatic colorectal cancer-QMH experience, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong College of Radiologists, 2012.
Law T.T., Chan K.K., Tong D.K.H., Chan S.Y., Wong W.H., Kwong D.L.W. and Law S.Y.K., Prognostic factors after esophaectomy for squamous cell carcinoma of the esophagus - does tumor location matter? SSAT Poster Session, SSAT ESOPHAGEAL: CLINICAL (III) , DDW 2013, Digestive Disease Week, Orlando, USA, 18-23 May 2013.
Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.
Lee V.H.F., Ng S.C., Leung T.W., Au G.K.H. and Kwong D.L.W., Dosimetric Predictors of Radiation-induced Acute Nausea and Vomiting in IMRT for Nasopharyngeal Cancer, International Journal of Radiation Oncology • Biology • Physics. Elsevier Inc., 2012, 84(1): 176-182.
Lee V.H.F., Choy T.S., Lam K.O., Kwong D.L.W. and Leung T.W., Predictors Of Treatment Outcome In Patients Treated With Radical Chemoradiotherapy For Stage Iii Non-small Cell Lung Cancer, Proffered Session, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Li J., Pow E.H.N., Zheng L., Ma L., Kwong D.L.W. and Cheung L.K., Effect of fluoride-modified titanium surface on irradiated osteoblast adhesion, Journal of Dental Research. 2012, 91(Spec IssC): 152.
Li J., Pow E.H.N., Zheng L., Ma L., Kwong D.L.W. and Cheung L.K., Factors affecting artifact of micro-CT scanning for implant, Journal of Dental Research. 2012, 91(Spec Iss C): 169410.
Lo M.C., Yip T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong R.N., Lo K.W., Ng W.T., Lee V.M., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasoharyngeal carcinoma tumour spheres, Cancer Lett.. 2013, Jul10;335(1): 81-92.
Pow E.H.N. and Kwong D.L.W., Jaw opening changes after radiotherapy for nasopharyngeal carcinoma, Journal of Dental Research. 2012, 91(Spec Iss C): 207.
Tian F., Yip S.P., Kwong D.L.W., Lin Z., Yang Z. and Wu V.W., Promotor hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma, Cancer Epidemiology. Elsevier Ltd., 2013, 37(5): 708–13.
Tsang J.W.H., Lam W.W.T., Liu K.Y., Soong S.I., Yung S.T., Kwong D.L.W. and Fielding R., Adaptation of Patient-centred Communication Skill Training for Medical Registrars – A Pilot Study, 3rd East Asia Psyho-Oncology Network (EAPON) Meeting 2012.
Tsang R.K.Y., Kwong D.L.W., Ho C.W.A., To V.S.H., Ho W.K. and Wei W.I., Long-Term Hearing Results and Otological Complications of Nasopharyngeal Carcinoma Patients: Comparison between Treatment with Conventional Two-Dimensional Radiotherapy and Intensity-Modulated Radiotherapy , ORL J Otorhinolaryngol Relat Spec. Basel, Karger, 2012, 74(4): 228-233.
Wei W.I. and Kwong D.L.W., Carcinoma of the nasopharynx, Head and Neck Cancer Recurrence: Evidence-based, Multidisciplinary Management. Germany, Thieme Medical Publishers, Inc., 2012.
Wong C.K.H., Lam C.L.K., Poon T.C.J. and Kwong D.L.W., Clinical Correlates of Health Preference and Generic Health-related Quality of Life in Patients with Colorectal Neoplasms, PLoS ONE. PLOS, 2013, 8(3): e58341.
Wong C.K.H., Lam C.L.K., Law W.L., Poon T.C.J., Kwong D.L.W., Tsang J.W.H. and Wan Y.F., Condition-specific Measure was More Responsive than Generic Measure in Colorectal Cancer: All but Social Domains, Journal of Clinical Epidemiology. Elsevier, 2013, 66(5): 557-565.
Wong C.K.H., Lam C.L.K., Mulhern B., Law W.L., Poon T.C.J., Kwong D.L.W. and Tsang J.W.H., Measurement invariance of the Functional Assessment of Cancer Therapy—Colorectal quality-of-life instrument among modes of administration, Quality of Life Research. Springer Netherlands, 2012, 22(6): 1415-1426.
Wong C.K.H., Lam C.L.K., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W. and Tsang J.W.H., Validity and Reliability Study on Traditional Chinese FACT-C on Chinese with Colorectal Neoplasm., Journal of Evaluation in Clinical Practice. 2012, 18: 1186-95.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of Candidate Epigenetic Markers for Early Detection of Nasopharyngeal Carcinoma, American Association for Cancer Research Annual Meeting 2013. Washington DC, AACR, Abstract# 3555.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of candidate epigenetic markers for early detection of nasopharyngeal carcinoma. , 2013.
Ying M., Zheng Y.P., Kot B.C., Cheung J.C., Cheng S.C. and Kwong D.L.W., Three-dimensional elastography for cervical lymph node volume measurements: a study to investigate feasibility, accuracy and reliability, Ultrasound in Medicine and Biology. 2013, 39(3): 396-406.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : LI J
List of Research Outputs

LI J., Lau G., Chen L., Yuan Y.F., Huang J., Luk J.M.C., Xie D. and Guan X., Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression, PLoS One. 2012, 7(9): e46264.
Zhu Y., Fu L., Chen L., Qin Y.R., Liu H., Xie F.J., Zeng T.T., LI J., Li Y., Dai Y., Xie D. and Guan X., Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. , Cancer Research. 2013, 73: 2298-2309.


Researcher : LIU M
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.


Researcher : Lam KO
Project Title:A prospective study on the predictive and prognostic value of baseline biomarker expressions in locally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine
Investigator(s):Lam KO, Kwong DLW, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2012


List of Research Outputs

Chan S.Y., Lam K.O. and Chu K.M., A patient with gastric adenocarcinoma and extensive metastases, In: MIMS Hong Kong, Oncology Tribune. MIMS Hong Kong, 2013.
Lai V., LI X., Lee V.H.F., Lam K.O., Chan Q. and Khong P.L., Intravoxel incoherent motion MR imaging: comparison of diffusion and perfusion characteristics between nasopharyngeal carcinoma and post-chemoradiation fibrosis, European Radiology. 2013.
Lai V., Li X., Lee V.H.F., Lam K.O., Chan Q. and Khong P.L., Use of Intravoxel Incoherent Motion Magnetic Resonance Imaging In Differentiation Between Recurrent Nasopharyngeal Carcinoma and Post-chemoradiation Fibrosis: Initial Experience. , 6th International Symposium of Nasopharyngeal Carcinoma 2013.
Lam K.O., Lee V.H.F., Liu R.K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab-containing regimens after cetuximab failure in Kras wild-type metastatic colorectal carcinoma, Oncology Letters. Spandidos Publications Ltd, 2013, 5: 637-640.
Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lam K.O., Cetuximab rechallenge: an additional therapeutic option in mCRC, Oncology Tribune. MIMS Hong Kong, 2012.
Lam K.O., Clinical case discussion on esophageal cancer, In: The JOC Bulletin, The JOC Bulletin, 2013, 28.
Lam K.O., Evolution Of Neoadjuvant Chemoirradiation In Rectal Cancer, The Hong Kong College of Radiologists. 2012.
Lam K.O., Evolution of Neoadjuvant Chemoirradiation in Rectal Cancer, In: Hong Kong College of Radiologists, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2012, 15: S33-9.
Lam K.O., Expert view: cetuximab in mCRC, Oncology Tribune. Oncology Tribune, 2013.
Lam K.O. and Lee V.H.F., Metastatic colorectal cancer: optimizing treatment with anti-EGFR monoclonal antibody, Journal of Cancer Therapy. Scientific Research Publishing Inc., 2012, 3: 902-911.
Lam K.O., Lau K.S., Ho P.Y., Lee V.H.F., Choy T.S., Liu R.K.Y., Kwong D.L.W. and Leung T.W., Safety and efficacy of cetuximab-XELOX combination in the first-line treatment of Kras wild-type metastatic colorectal cancer-QMH experience, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong College of Radiologists, 2012.
Lam K.O., To feed or not to feed: artificial nutrition in the terminally ill, The 19th International Cancer Congress. 2012.
Lam K.O., What does "CLASSIC" mean in the Adjuvant Treatment of Gastric Cancer?, Joint Oncology Conference Bulletin. UBM Medica, 2012.
Lee V.H.F., Choy T.S., Lam K.O., Kwong D.L.W. and Leung T.W., Predictors Of Treatment Outcome In Patients Treated With Radical Chemoradiotherapy For Stage Iii Non-small Cell Lung Cancer, Proffered Session, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.


Researcher : Lee AWM
List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.
LAU H.Y., Liang J., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and asopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13: 298.
LAU H.Y., Leung C.M., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13(1): 13:298.
Lee A.W.M., Sze C.K.H. and Ng W.T., Is selective neck irradiation safe for node-negative nasopharyngeal carcinoma?, Int J Radiat Oncol Biol Phys. Elsevier, 2013, 85: 902-3.
Lee A.W.M., Ng W.T., Chan Y.H., Sze C.K.H., Chan C. and Lam T.H., The battle against nasopharyngeal cancer, Radiotherapy and Oncology. 2012, 104(3): 272-8.
Lee A.W.M., Ng W.T., Chan L.K., Chan O.S.H., Hung W.M., Chan C.C., Cheng P.T., Sze C.K.H., Lam T.S. and Yau T.K., The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement, Oral Oncol. 2012, 48: 1007-13.
Luk Y.S., Shum J.S., Sze C.K.H., Chan L.L., Ng W.T. and Lee A.W.M., Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy., Oral Oncol. 2013, 49: 49-54.


Researcher : Lee VHF
Project Title:A retrospective analysis of genetic aberrations as predictors of relapse and survival outcomes in completely resected stage III adenocarcinoma of colon after the use of oxaliplatin-based regimen as adjuvant chemotherapy
Investigator(s):Lee VHF, Chua DTT, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2009


Project Title:Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:A prospective study on the anatomical and physiological changes of carotid arteries by doppler ultrasonography after Intensity Modulated Radiation Therapy (IMRT) for untreated nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Wong CS, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


Project Title:Host, Salivary, Virulent and Molecular Attributes to the Development of Oral Candidiasis During Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma (NPC) – A Prospective Study
Investigator(s):Lee VHF, Seneviratne CJ, Samaranayake LP, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2012


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2012


Project Title:Identification of epithelial stem cells and factors predicting recovery of mucositis after intensity modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Guan X, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Lai V., LI X., Lee V.H.F., Lam K.O., Chan Q. and Khong P.L., Intravoxel incoherent motion MR imaging: comparison of diffusion and perfusion characteristics between nasopharyngeal carcinoma and post-chemoradiation fibrosis, European Radiology. 2013.
Lai V., Li X., Lee V.H.F., Lam K.O., Chan Q. and Khong P.L., Use of Intravoxel Incoherent Motion Magnetic Resonance Imaging In Differentiation Between Recurrent Nasopharyngeal Carcinoma and Post-chemoradiation Fibrosis: Initial Experience. , 6th International Symposium of Nasopharyngeal Carcinoma 2013.
Lam K.O., Lee V.H.F., Liu R.K.Y., Leung T.W. and Kwong D.L.W., Bevacizumab-containing regimens after cetuximab failure in Kras wild-type metastatic colorectal carcinoma, Oncology Letters. Spandidos Publications Ltd, 2013, 5: 637-640.
Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lam K.O. and Lee V.H.F., Metastatic colorectal cancer: optimizing treatment with anti-EGFR monoclonal antibody, Journal of Cancer Therapy. Scientific Research Publishing Inc., 2012, 3: 902-911.
Lam K.O., Lau K.S., Ho P.Y., Lee V.H.F., Choy T.S., Liu R.K.Y., Kwong D.L.W. and Leung T.W., Safety and efficacy of cetuximab-XELOX combination in the first-line treatment of Kras wild-type metastatic colorectal cancer-QMH experience, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong College of Radiologists, 2012.
Lee V.H.F., Clinical Experience Sharing on the use of Anti-VEGF therapy for non-small cell lung cancer, Roche Hong Kong Limited. Hong Kong, Roche Hong Kong Limited, 2012.
Lee V.H.F., Clinical Experience Sharing on the use of anti-VEGF therapy for non-small cell lung cancer, Macau Chest Diseases and Tuberculosis Association. Macau, Macau Chest Diseases and Tuberculosis Association, 2012.
Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.
Lee V.H.F., Comparative analysis of the efficacy of prophylactic pegfilgrastim versus filgrastim for patients with soft tissue sarcoma and testicular germ cell tumours receiving potent cytotoxic chemotherapy, Proffered session, Annual Scientific Meeting 2011, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Lee V.H.F., Ng S.C., Leung T.W., Au G.K.H. and Kwong D.L.W., Dosimetric Predictors of Radiation-induced Acute Nausea and Vomiting in IMRT for Nasopharyngeal Cancer, International Journal of Radiation Oncology • Biology • Physics. Elsevier Inc., 2012, 84(1): 176-182.
Lee V.H.F., Palliative radiotherapy for lung cancer, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Lee V.H.F., Personalized treatment for lung cancer at Lung Cancer Symposium, organised by Hong Kong College of Radiologists, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Lee V.H.F., Choy T.S., Lam K.O., Kwong D.L.W. and Leung T.W., Predictors Of Treatment Outcome In Patients Treated With Radical Chemoradiotherapy For Stage Iii Non-small Cell Lung Cancer, Proffered Session, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Lee V.W.Y. and Lee V.H.F., Comparative effectiveness and cost-effectiveness assessment in erlotinib vs. gefitinib first-line treatment of EGFR activating mutation positive non-small cell lung cancer for Hong Kong, ISPOR 5th Asia-Pacific Conference. Taiwan, ISPOR, 2012.
Ng C.Y., Lee V.H.F. and Leung T.W., Dosimetric Evaluation of the Interplay between LINAC Movement and Tumor Motion in Respiratory Gated VMAT of Lung Cancer , American Society for Radiation Oncology 54th Annual Meeting. 2012.
Ye M., Lam W.W.T., Tsang J.W.H., Lee V.H.F., Soong I., Chan K.K.L., Lee C., Sze W.K., Yeo W., Suen J., Ho W.M. and Fielding R., Symptom clustering in different groups of cancer survivors (abstract and powerpoint presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking University, 2012, 18-19.
Ye M., Lam W.W.T., Tsang J.W.H., Lee V.H.F., Soong I., Chan K.K.L., Lee C., Sze W.K., Ng A., Yeo W., Suen J., Ho W.M. and Fielding R., Symptom clusters in cancer survivors in Hong Kong - a cluster analysis (abstract), 19th Hong Kong International Cancer Congress, 8-9 November 2012, Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2012, A72.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Leung TW
List of Research Outputs

Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.
Lee V.H.F., Ng S.C., Leung T.W., Au G.K.H. and Kwong D.L.W., Dosimetric Predictors of Radiation-induced Acute Nausea and Vomiting in IMRT for Nasopharyngeal Cancer, International Journal of Radiation Oncology • Biology • Physics. Elsevier Inc., 2012, 84(1): 176-182.
Lee V.H.F., Choy T.S., Lam K.O., Kwong D.L.W. and Leung T.W., Predictors Of Treatment Outcome In Patients Treated With Radical Chemoradiotherapy For Stage Iii Non-small Cell Lung Cancer, Proffered Session, Annual Scientific Meeting 2012, Hong Kong College of Radiologists. Hong Kong, Hong Kong College of Radiologists, 2012.
Ng C.Y., Lee V.H.F. and Leung T.W., Dosimetric Evaluation of the Interplay between LINAC Movement and Tumor Motion in Respiratory Gated VMAT of Lung Cancer , American Society for Radiation Oncology 54th Annual Meeting. 2012.


Researcher : Li Y
Project Title:Chromatin, Replication and Chromosomal Stability 2013; Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
Investigator(s):Li Y
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.


Researcher : Liu KY
List of Research Outputs

Gu J., Khong P.L., Wang S., Law W.L., Chan T., Shek T.W.H., Liu K.Y. and Zhang J., Combined use of 18F-FDG PET/CT DW-MRI and DCE-MRI in treatment response for preoperative chemoradiation therapy in locally invasive rectal cancers, Clinical Nuclear Medicine. 2013, 38(5): e226-229.
Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Tsang J.W.H., Lam W.W.T., Liu K.Y., Soong S.I., Yung S.T., Kwong D.L.W. and Fielding R., Adaptation of Patient-centred Communication Skill Training for Medical Registrars – A Pilot Study, 3rd East Asia Psyho-Oncology Network (EAPON) Meeting 2012.


Researcher : Liu M
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.
Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.


Researcher : Luk MY
List of Research Outputs

Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.


Researcher : Lung HL
Project Title:The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma
Investigator(s):Lung HL, Chua DTT
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2009
Completion Date:08/2012


Project Title:Investigation of the X-linked candidate genes which escape the X-inactivation in nasopharyngeal carcinoma
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Investigation of the sixth base, 5-hydroxymethylcytosine, in nasopharyngeal carcinoma
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:6th International Nasopharyngeal Carcinoma Symposium ; The role of serum amyloid A1 (SAA1) polymorphisms in nasopharyngeal carcinoma (NPC)
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.
Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.
Lung H.L. and Lung M.L., In vivo Matrigel Plug Angiogenesis Assay. , In: Fanglian He , Bioprotocol. 2012.
Lung H.L., Reviewer, Bioprotocol for manuscript 1. 2013.
Lung H.L., Reviewer, Cancer Letter for manuscript . 2012.
Lung H.L., Reviewer, Journal of Experimental & Clinical Cancer Research for manuscript . 2012.
Lung H.L., MAN O.Y., Chung Y.M., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) polymorphisms in nasopharyngeal carcinoma (NPC), 2013.
SHUEN W.H., Lung H.L. and Lung M.L., Candidate tumor suppressor Fibulin-2 inhibits angiogenesis and migration through the regulation of p65 and Rho GTPases. , The 6th International Symposium on Nasopharyngeal Carcinoma,. 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.


Researcher : Lung ML
Project Title:Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2009


Project Title:Centre for Nasopharyngeal Carcinoma Research
Investigator(s):Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:Clinical Oncology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2010


Project Title:Role of DNAJB6 epithelial-mesenchymal transition in esophageal squamous cell carcinoma tumorigenesis and metastasis
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Identifying germline alterations associated with familial esophageal squamous cell carcinoma
Investigator(s):Lung ML, Ko JMY
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013


List of Research Outputs

Chan K.C., Choi M.T., Chan P.S., Lo M.C., Lo K.W., Curry J.E., Smyth T., Lee A.W., Ng W.T., Tsao G.S.W., Wong R.N., Lung M.L. and Mak N.K., Study of a novel Hsp90 inhibitor AT13387 in EBV-positive nasopharyngeal carcinoma cells. , The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.
Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers for stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1. , The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers from stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1, The 6th International Nasopharyngeal Carcinoma Symposium . Istanbul, Ea Organization, 2013, O-31.
Cheung A.K.L. and Lung M.L., Protein tyrosine phosphatase receptor type G regulates Akt- and β-catenin-associated epithelial-mesenchymal transition in nasopharyngeal carcinoma, The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.
Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.
LAU H.Y., Liang J., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and asopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13: 298.
LAU H.Y., Leung C.M., Chan Y.H., Lee A.W.M., Kwong D.L.W., Lung M.L. and Lam T.H., Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents, BMC Cancer. 2013, 13(1): 13:298.
Lo M.C., Yip T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong R.N., Lo K.W., Ng W.T., Lee V.M., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasoharyngeal carcinoma tumour spheres, Cancer Lett.. 2013, Jul10;335(1): 81-92.
Lung H.L. and Lung M.L., In vivo Matrigel Plug Angiogenesis Assay. , In: Fanglian He , Bioprotocol. 2012.
Lung H.L., MAN O.Y., Chung Y.M., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) polymorphisms in nasopharyngeal carcinoma (NPC), 2013.
SHUEN W.H., Lung H.L. and Lung M.L., Candidate tumor suppressor Fibulin-2 inhibits angiogenesis and migration through the regulation of p65 and Rho GTPases. , The 6th International Symposium on Nasopharyngeal Carcinoma,. 2013.
SHUEN W.H. and Lung M.L., Fibulin-2 suppresses tumor growth and angiogenesis through the inhibition of Erk1/2 and p65 pathways in nasopharyngeal carcinoma. , Annual Meeting of American Association of Cancer Research. 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., LAU M.Y., Takada K., Lui V.W. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proc Natl Acad Sci USA. 2012, 109(50): E3473-82.
Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of Candidate Epigenetic Markers for Early Detection of Nasopharyngeal Carcinoma, American Association for Cancer Research Annual Meeting 2013. Washington DC, AACR, Abstract# 3555.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of candidate epigenetic markers for early detection of nasopharyngeal carcinoma. , 2013.
Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.


Researcher : MAN OY
List of Research Outputs

Lung H.L., MAN O.Y., Chung Y.M., Chua D. and Lung M.L., The role of serum amyloid A1 (SAA1) polymorphisms in nasopharyngeal carcinoma (NPC), 2013.


Researcher : MING X
List of Research Outputs

Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.


Researcher : Ma SKY
Project Title:Transcriptome sequencing (RNA-Seq) identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal carcinoma (ESCC)
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011
Completion Date:07/2012


Project Title:Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


Project Title:Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):Ma SKY, Wong AST
Department:Pathology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2012


Project Title:Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):Ma SKY, Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Epigenetic modulation of CD133+ liver cancer stem cells by chromatin-modifying enzymes
Investigator(s):Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:International Liver Transplantation Society - 19th Annual International Congress; Biology and clinical implications of CD133+ liver cancer stem cells
Investigator(s):Ma SKY
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Chai S. and Ma S.K.Y., Clinical implications of miRNA in liver cancer stem cells, Chin J Cancer. 2013, 2013.
Dai Y.D., Liu L.L., Zeng T.T., Zhu Y.H., Li J.C., Chen L., Li Y., Yuan Y.F., Ma S.K.Y. and Guan X., Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma, Biochem Biophys Res Commun. 2013, 2013.
Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.
Ma S.K.Y., Biology and clinical implications of CD133+ liver cancer stem cells, Exp Cell Res. 2013, 2013; 319: 126-32.
Ma S.K.Y., Biology and clinical implications of liver cancer stem cells, International Liver Transplantation Society (ILTS) - 19th Annual International Congress. 2013.
Ma S.K.Y., Dissecting liver cancer stem cells - CD133 and beyond, 2012 Merck Millipore Asia Bio-Forum. 2012.
Ma S.K.Y., Faculty Outstanding Research Output Award, The University of Hong Kong, Faculty of Medicine, The University of Hong Kong. 2012, 2012.
Ma S.K.Y., Significance of neurotensin-induced IL-8 signaling in CD133+ liver cancer stem cells-induced hepatocellular carcinoma, Symposium 2012 of State Key Laboratory for Liver Research. 2012.
TONG M., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - Stem Cells and Cancer 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Lok S., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - "Stem Cells & Cancer". 2013.
Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.


Researcher : Ng CY
List of Research Outputs

CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Accuracy and sensitivity of four-dimensional dose calculation to systematic motion variability in stereotatic body radiotherapy (SBRT) for lung cancer, Journal of Applied Clinical Medical Physics. 2012, 13(6): 3992.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tong A.S. and Tam E.K., Experimental evaluations of the accuracy of 3D and 4D planning in robotic tracking stereotactic body radiotherapy for lung cancers, Medical Physics. 2013, 40(4): 041712.
CHAN K.H., Kwong D.L.W., Ng C.Y., Tam E.K. and Tong A.S., Investigation of four-dimensional (4D) Monte Carlo dose calculation in real-time tumor tracking stereotatic body radiotherapy for lung cancers, Medical Physics . 2012, 39(9): 5479-87.
Hung K.N., Ng C.Y., Lui W.M. and Taw B.T., XXth ESSFN conference, XXth ESSFN conference. 2012.
Lee V.H.F., Ng C.Y., Choi C.W., Luk M.Y., Leung T.W., Au G.K.H. and Kwong D.L.W., Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation., Radiation Oncology. Radiation Oncology, 2012, 7: 199.
Ng C.Y., Lee V.H.F. and Leung T.W., Dosimetric Evaluation of the Interplay between LINAC Movement and Tumor Motion in Respiratory Gated VMAT of Lung Cancer , American Society for Radiation Oncology 54th Annual Meeting. 2012.


Researcher : Ng WT
List of Research Outputs

Lee A.W.M., Sze C.K.H. and Ng W.T., Is selective neck irradiation safe for node-negative nasopharyngeal carcinoma?, Int J Radiat Oncol Biol Phys. Elsevier, 2013, 85: 902-3.
Lee A.W.M., Ng W.T., Chan Y.H., Sze C.K.H., Chan C. and Lam T.H., The battle against nasopharyngeal cancer, Radiotherapy and Oncology. 2012, 104(3): 272-8.
Lee A.W.M., Ng W.T., Chan L.K., Chan O.S.H., Hung W.M., Chan C.C., Cheng P.T., Sze C.K.H., Lam T.S. and Yau T.K., The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement, Oral Oncol. 2012, 48: 1007-13.
Luk Y.S., Shum J.S., Sze C.K.H., Chan L.L., Ng W.T. and Lee A.W.M., Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy., Oral Oncol. 2013, 49: 49-54.


Researcher : PHOON YP
List of Research Outputs

Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers for stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1. , The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.
Cheng Y., PHOON Y.P. and Lung M.L., Identification of stemness markers from stem cell-like cells derived from nasopharyngeal carcinoma cell line HONE1, The 6th International Nasopharyngeal Carcinoma Symposium . Istanbul, Ea Organization, 2013, O-31.
Cheung A.K.L., PHOON Y.P., Lung H.L., Ko J.M.Y., Cheng Y. and Lung M.L., Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells, In: Yue Cheng, Future Aspects of Tumor Suppressor Gene. Croatia, InTech, 2013, 75-96.


Researcher : SHUEN WH
List of Research Outputs

SHUEN W.H., Lung H.L. and Lung M.L., Candidate tumor suppressor Fibulin-2 inhibits angiogenesis and migration through the regulation of p65 and Rho GTPases. , The 6th International Symposium on Nasopharyngeal Carcinoma,. 2013.
SHUEN W.H. and Lung M.L., Fibulin-2 suppresses tumor growth and angiogenesis through the inhibition of Erk1/2 and p65 pathways in nasopharyngeal carcinoma. , Annual Meeting of American Association of Cancer Research. 2013.


Researcher : Sham JST
List of Research Outputs

Chan H.Y., Yuen L.P., Lee T., Chan J.S.M., Sham J.S.T. and Chan C.L.W., Effects of Qigong exercise on quality of life and cognitive functioning in people with cancer, 34th Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine, March 20-23, 2013, San Francisco, California, U.S., D-176k.. 2013.
Ho R.T.H., Chan S.M., Wang C., Lau B.W.M., So K.F., Yuen L.P., Sham J.S.T. and Chan C.L.W., A randomized controlled trial of qigong exercise on telomerase activity in persons with chronic fatigue and chronic fatigue syndrome , Annals of Behaviorial Medicine. 2012, 44: 160-170.


Researcher : Song Y
List of Research Outputs

Chen L., Li Y., Lin C., Chan H.M., Chow K.K., Song Y., Liu M., Yuan Y.F., Fu L., Kong K.L., Qi L., Li Y., Zhang N., Tong A.H.Y., Kwong D.L.W., Man K., Lo C.M., Lok S., Tenen D.G. and Guan X., Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nature Medicine. 2013, 19(2): 209-216.


Researcher : Soong SI
List of Research Outputs

Tsang J.W.H., Lam W.W.T., Liu K.Y., Soong S.I., Yung S.T., Kwong D.L.W. and Fielding R., Adaptation of Patient-centred Communication Skill Training for Medical Registrars – A Pilot Study, 3rd East Asia Psyho-Oncology Network (EAPON) Meeting 2012.


Researcher : Sze CKH
List of Research Outputs

Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lee A.W.M., Sze C.K.H. and Ng W.T., Is selective neck irradiation safe for node-negative nasopharyngeal carcinoma?, Int J Radiat Oncol Biol Phys. Elsevier, 2013, 85: 902-3.
Lee A.W.M., Ng W.T., Chan Y.H., Sze C.K.H., Chan C. and Lam T.H., The battle against nasopharyngeal cancer, Radiotherapy and Oncology. 2012, 104(3): 272-8.
Lee A.W.M., Ng W.T., Chan L.K., Chan O.S.H., Hung W.M., Chan C.C., Cheng P.T., Sze C.K.H., Lam T.S. and Yau T.K., The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement, Oral Oncol. 2012, 48: 1007-13.
Luk Y.S., Shum J.S., Sze C.K.H., Chan L.L., Ng W.T. and Lee A.W.M., Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy., Oral Oncol. 2013, 49: 49-54.
Sze C.K.H., Junior editor, Hong Kong Journal of Radiology. 2013.
Sze C.K.H., New Treatment in Oncology, Hong Kong Primary Care Conference. 2013.
Sze C.K.H., We treat pain. We cause pain., Hong Kong Pain Society Pain Education Series: “Practical management of cancer pain”. 2013.


Researcher : Szeto CYY
Project Title:Critical genomic regions and mi-RNA regulation in nasopharyngeal carcinoma
Investigator(s):Szeto CYY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:08/2012


List of Research Outputs

YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of Candidate Epigenetic Markers for Early Detection of Nasopharyngeal Carcinoma, American Association for Cancer Research Annual Meeting 2013. Washington DC, AACR, Abstract# 3555.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of candidate epigenetic markers for early detection of nasopharyngeal carcinoma. , 2013.


Researcher : TONG M
List of Research Outputs

Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.
TONG M., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - Stem Cells and Cancer 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Lok S., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - "Stem Cells & Cancer". 2013.
Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.


Researcher : Tong M
List of Research Outputs

Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.
TONG M., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - Stem Cells and Cancer 2013.
Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.
Tong M., Lok S., Yuan Y.F., Hui L.J., Guan X. and Ma S.K.Y., Annexin A3 (ANXA3) confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, Gordon Research Conference - "Stem Cells & Cancer". 2013.
Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.
Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.


Researcher : Tsang JWH
Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang JWH, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:Training Oncology Interns in Patient-centred Communication
Investigator(s):Tsang JWH, Lam WWT, Fielding R
Department:Clinical Oncology
Source(s) of Funding:Hong Kong Cancer Fund - General Award
Start Date:04/2011


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang JWH, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):Tsang JWH, Khoo US
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


List of Research Outputs

Hon Y.Y.L., Fielding R., Lam W.W.T., Lai C.L., Yuen R.M.F., Ip D.K.M. and Tsang J.W.H., Validation of the Chinese version of the Revised-IPQ: Illness Perception Questionnaire-Revised for Cancer Predisposition (IPQ-CP) (abstract and poster presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking, 2012, 44-45.
Lam K.O., Lee V.H.F., Choi C.W., Sze C.K.H., Kwok R.C.C., Shum B.C.Y., Wong I.W.C., Tsang J.W.H., Liu K.Y., Leung T.W. and Kwong D.L.W., Cetuximab beyond progression in Kras wild-type metastatic colorectal cancer, In: Annals of Oncology, ESMO 15th World Congress on Gastrointestinal Cancer. Annals of Oncology, 2013, 24; Suppl. 4.
Lam W.W.T., Ng J., Tsang J.W.H., Yau T.K., Soong I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng A. and Fielding R., Patterns of psychological distress among Chinese women diagnosed with advanced breast cancer (abstract and powerpoint presentation), 2012 Joint Meeting of IPOS 14th World Congress and COSA's 39th Annual Scientific Meeting, 13-15 November 2012, Brisbane, Australia. Brisbane, International Psycho-Oncology Society, 2012.
Li W.Y., Lam W.W.T., Au H.Y.A., Law W.L., Poon T.C.J., Kwong A., Suen T.K.D., Tsang J.W.H., Girgis A. and Fielding R., Comparing supportive care needs patterns in breast and colorectal cancer patients (abstract and powerpoint presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking University, 2012, 24-25.
Li W.Y., Lam W.W.T., Au H.Y.A., Ye M., Law W.L., Poon T.C.J., Kwong A., Suen T.K.D., Tsang J.W.H., Girgis A. and Fielding R., Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer, Psycho-Oncology. 2013, 22(4): 792-8.
Tsang J.W.H., Lam W.W.T., Liu K.Y., Soong S.I., Yung S.T., Kwong D.L.W. and Fielding R., Adaptation of Patient-centred Communication Skill Training for Medical Registrars – A Pilot Study, 3rd East Asia Psyho-Oncology Network (EAPON) Meeting 2012.
Tsang J.W.H., Best of ASCO - Breast Cancer 2012, Chinese Society of Clinical Oncology Best of ASCO Annual Meeting, Nanjing, 2012. 2012.
Tsang J.W.H., Hong Kong City Lady Award 2012 - Professional & Academic Category, 「全港時尚專業女性選舉」-專業及學術界, Junior Chamber International Hong Kong. 城市女青年商會, 2012.
Tsang J.W.H., Real Cases Sharing for Metastatic Breast Cancer Patients with Bone Metastasis, Hong Kong College of Radiologists Summer Symposium. 2012.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
Wong A.M.G., Tsang J.W.H. and Guan X., Reply to profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2012, 118(8): 4634-4635.
Wong C.K.H., Lam C.L.K., Law W.L., Poon T.C.J., Kwong D.L.W., Tsang J.W.H. and Wan Y.F., Condition-specific Measure was More Responsive than Generic Measure in Colorectal Cancer: All but Social Domains, Journal of Clinical Epidemiology. Elsevier, 2013, 66(5): 557-565.
Wong C.K.H., Lam C.L.K., Mulhern B., Law W.L., Poon T.C.J., Kwong D.L.W. and Tsang J.W.H., Measurement invariance of the Functional Assessment of Cancer Therapy—Colorectal quality-of-life instrument among modes of administration, Quality of Life Research. Springer Netherlands, 2012, 22(6): 1415-1426.
Wong C.K.H., Lam C.L.K., Law W.L., Poon T.C.J., Chan P., Kwong D.L.W. and Tsang J.W.H., Validity and Reliability Study on Traditional Chinese FACT-C on Chinese with Colorectal Neoplasm., Journal of Evaluation in Clinical Practice. 2012, 18: 1186-95.
Wong O.L., Tsang J.W.H., Cowling B.J. and Leung G.M., Optimizing resource allocation for breast cancer prevention and care among Hong Kong Chinese women, Cancer. 2012, 118(8): 4394-4403.
Ye M., Lam W.W.T., Tsang J.W.H., Lee V.H.F., Soong I., Chan K.K.L., Lee C., Sze W.K., Yeo W., Suen J., Ho W.M. and Fielding R., Symptom clustering in different groups of cancer survivors (abstract and powerpoint presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking University, 2012, 18-19.
Ye M., Lam W.W.T., Tsang J.W.H., Lee V.H.F., Soong I., Chan K.K.L., Lee C., Sze W.K., Ng A., Yeo W., Suen J., Ho W.M. and Fielding R., Symptom clusters in cancer survivors in Hong Kong - a cluster analysis (abstract), 19th Hong Kong International Cancer Congress, 8-9 November 2012, Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2012, A72.


Researcher : WONG AMG
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
Wong A.M.G., Tsang J.W.H. and Guan X., Reply to profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2012, 118(8): 4634-4635.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Wang J
List of Research Outputs

Hu L., Liu M., Chen L., Wang J., Huo K.K., Zheng B., Xie D. and Guan X., SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. , Carcinogenesis. 2012, 33: 1581-1588.


Researcher : Wong AMG
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Wong A.M.G., Chen J., Ma S.K.Y., Tsang J.W.H. and Guan X., Epstein-Barr virus encoded BART microRNAs facilitate nasopharyngeal carcinoma development and progression via deregulation of Wnt signaling, The American Association for Cancer Research - Annual Meeting. 2013.
Wong A.M.G., Tsang J.W.H. and Guan X., Reply to profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs, Cancer. 2012, 118(8): 4634-4635.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : Wong CL
List of Research Outputs

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.


Researcher : YANG X
List of Research Outputs

YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of Candidate Epigenetic Markers for Early Detection of Nasopharyngeal Carcinoma, American Association for Cancer Research Annual Meeting 2013. Washington DC, AACR, Abstract# 3555.
YANG X., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Identification of candidate epigenetic markers for early detection of nasopharyngeal carcinoma. , 2013.


Researcher : Yau TK
List of Research Outputs

Lee A.W.M., Ng W.T., Chan L.K., Chan O.S.H., Hung W.M., Chan C.C., Cheng P.T., Sze C.K.H., Lam T.S. and Yau T.K., The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement, Oral Oncol. 2012, 48: 1007-13.


Researcher : Yung ST
List of Research Outputs

Tsang J.W.H., Lam W.W.T., Liu K.Y., Soong S.I., Yung S.T., Kwong D.L.W. and Fielding R., Adaptation of Patient-centred Communication Skill Training for Medical Registrars – A Pilot Study, 3rd East Asia Psyho-Oncology Network (EAPON) Meeting 2012.


Researcher : ZHANG L
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Chen J., Kwong D.L.W., CAO T., HU Q., ZHANG L., MING X., CHEN J., Fu L. and Guan X., Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics, Diseases of the Esophagus . Wiley Periodicals, Inc., 2013, Epub ahead of print.
ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.


Researcher : ZHU C
List of Research Outputs

CHEN J., Kwong D.L.W., ZHU C., Chen L., Dong S., ZHANG L., Tian J., Qi C.B., CAO T., WONG A.M.G., Kong K.L., Li Y., LIU M., Fu L. and Guan X., RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis., PLoS One. 2012, 7(9): e44636.
Li Y., ZHU C., Nie C.J., Li J.C., Zeng T.T., Zhou J., CHEN J., Chen K., Liu H., Qin Y.R. and Guan X., Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma., PLoS One . 2013, 8: e60027.


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