Dept of Biochemistry

DEPT OF BIOCHEMISTRY

Researcher : AO KL

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Ao K.L., Shum K.T. and Tanner J.A., Investigation of the protein/Polyphosphate binding interface: mutational studies on mycobacterium tuberculosis polyphosphate kinase 2 (PPK2), 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Researcher : Ao KL

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Researcher : Au YK

Project Title:	Developing a culture system for notochord and nucleus pulposus cells
Investigator(s):	Au YK, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2012

List of Research Outputs

Au Y.K., Poster Prize, Understanding the molecular impact of Sox9Y440X in campomelic dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Au Y.K., Wynn S.A.R.A.H. .L., Szeto Y.Y., Geng Y.H., Lovell-Badge R.H., Cheung K.M.C. and Cheah K.S.E., Understanding the molecular impact of Sox9Y440X in campomelic dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Faessler R. and Cheah K.S.E., Fine-tuning of notochord midline position via cell-matrix interactions, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Lim F.L., Au Y.K., Cheah K.S.E., Chan D., Tuan R.S., Cheung K.M.C. and Leung Y.L., Cadherin 2/N-cadherin regulates notochordal cell function and intervertebral disc homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

NG T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of the Nucleus Pulposus Cells for Degenerative Disc Disorder, Gordon Research Conference on Cartilage Biology & Pathology. Les Diablerets, Switzerland, 2013.

Ng T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of Nucleus Pulposus Cells for Degenerative Disc Disorder, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

Researcher : BAO S

List of Research Outputs

BAO S., Zhou X. and Song Y., Integrating genetic linkage analysis and computational prioritization in identifying host genetic factors response to influenza A virus infection, The 62nd Annual Meeting of the American Society of Human Genetics. 2012.

BAO S., Niu G. and Song Y., Novel sequence motif regulates pluripotency, Annual meeting of the American Society of Human Genetics, 2012; . 2012.

Li M., Kwan S.H., Bao S., Yang W., Ho S.L., Song Y. and Sham P.C., Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies, PLos Genet. 2013, 9(1): e1003143.

Researcher : Bao S

List of Research Outputs

BAO S., Niu G. and Song Y., Novel sequence motif regulates pluripotency, Annual meeting of the American Society of Human Genetics, 2012; . 2012.

Researcher : Boyde TRC

List of Research Outputs

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2012.

Researcher : CHAN CWW

List of Research Outputs

FENG C., CHAN C.W.W., Cheah K.S.E. and Chan D., Best Poster Award (poster entitled "Descendents of Lgr5-expressing interzone cells are localized to the superficial layer of the articular cartilage"), In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Researcher : CHAU WH

List of Research Outputs

Jia Y., Chau W.H., Zhang Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

YUAN Q.J., SU H.X., CHAU W.H., Ng G.C.T., Huang J., Wu W. and Lin Z.H.I.-.X.I.U., Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease, PLoS One. 2012, V8(1): e53480.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

Researcher : CHEUNG YW

List of Research Outputs

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., The use of aptamer-conjugated nanoparticles in novel malaria diagnosis platforms, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Tanner J.A., Cheung Y.W. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis, PCT International Application. 2013, PCT/CN2013/071467.

Researcher : Cham WC

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic function in the central vestibular circuitry. Int’l Conference of Physiological Sciences 2012, The Chinese Association for Physiological Sciences Symposium - Synaptic Function and Plasticity in Health and Disease. Acta Physiologica Sinica . 2012, 64: 11.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Society Neuroscience Abstract (USA), 845.23/C18. 2012.

Ma C.W., Lam Y.L., Cham W.C., Han L., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic function of the central vestibular system, Gordon Research Conferences (Proteoglycans), Andover, USA. Jul 8-13. 2012.

Researcher : Cham WC

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Researcher : Chan CCY

Project Title:	Role of Sedlin in the control of endocytosis
Investigator(s):	Chan CCY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Chan C.C.Y., Tanner J.A., Chan D., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of Sedlin and Sedlin-like proteins in mouse yolk-sac visceral endoderm and embryo development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Chan CH

List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase activity enhances MMP-7 dependent syndecan-1 shedding in the airway, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Chan CP

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Understanding innate immune response to influenza A viruses using reverse genetics and TALEN technology, Joint Research Conference on Molecular Oncology, Guangzhou, China. 2012.

Jin D., Kok K.H., Tang V.H.M., LUI P.Y. and Chan C.P., Suppression of type I interferon production by human T-cell leukemia virus type 1 Tax oncoprotein , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013.

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

Researcher : Chan CP

List of Research Outputs

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Chan B.P., Cheng H.W., Chan D., Cheung K.M.C. and Yan C.H., Mesenchymal stem cell based osteochondral tissue engineering., Gordon Research Conference on Cartilage Biology and Pathology. . 2013, 8.

Chan C.C.Y., Tanner J.A., Chan D., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of Sedlin and Sedlin-like proteins in mouse yolk-sac visceral endoderm and embryo development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.C.W., Cheah K.S.E. and Chan D., Cells in the endplate contribute to the maintenance and repair of the inner Annulus fibrosus, In: W. C. W. Chan, K. S. Cheah, D. Chan, Global Spine Congress 2013.

Chan W.C.W., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, In: WCW Chan, KSE Cheah and D Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Chan W.C.W., Zhang L., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Eskola P.J., Lemmela S., Kjaer P.K., Solovieva S., Mannikko M., Tommerup N., Lind-Thomsen A., Husgafvel-Pursiainen K., Cheung K.M.C., Chan D., Samartzis D. and Karppinen J.I., Genetic association studies in lumbar disc degeneration: a systematic review, Global Spine Congress. Hong Kong, 2013.

Eskola P.J., Lemmela S., Kjaer P.K., Solovieva S., Mannikko M., Tommerup N., Lind-Thomsen A., Husgafvel-Pursiainen K., Cheung K.M.C., Chan D., Samartzis D. and Karppinen J., Genetic association studies in lumbar disc degeneration: a systematic review, PLoS One. 2012, 7(11): e49995.

FENG C., CHAN C.W.W., Cheah K.S.E. and Chan D., Best Poster Award (poster entitled "Descendents of Lgr5-expressing interzone cells are localized to the superficial layer of the articular cartilage"), In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

FENG C., Chan W.C.W., Ng V.C.W., Cheah K.S.E. and Chan D., Descendents Of Lgr5-expressing Interzone Cells Are Localized To The Superficial Layer Of The Articular Cartilage, In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Feng C., Chan W.C.W., Mundlos S., Hui N.H. and Chan D., Differentiation and progression of interzone cells as progenitors of articular condrocytes in joint formaiton, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of Kinesin-1 mediated intracellular transport in skeletal development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Gao Y., Leung W.L., Wong S.Y.Y., Chan D., Tam P.L.P. and Cheah K.S.E., Type IIA procollagen: A Positive Regulator of Nodal Signaling during Early Embryogenesis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Faessler R. and Cheah K.S.E., Fine-tuning of notochord midline position via cell-matrix interactions, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Huang S., Leung Y.L., Long D., Chan D., Lu W.W., Cheung K.M.C. and Zhou G., Coupling of small leucine-rich proteoglycans to hypoxic survival of a progenitor cell-like subpopulation in Rhesus Macaque intervertebral disc, Biomaterials. 2013, 34(28): 6548-58.

Kwok C.B., Ho F.C., Li C.W., Ngan A.H.W., Chan D. and Chan B.P., Compression induced alignment and elongation of human mesenchymal stem cell (hMSC) in 3D collagen constructs is collagen concentration dependent, Journal of Biomedical Materials Research Part A. 2012.

LAM T.K., Cheung K.M.C., Chan D. and Leung Y.L., Fate of notochord descendent cells in the intervertebral disc. 2013.

Leung Y.L., SUN Y., TSUI Y.K., Masuda K., Chan D. and Cheung K.M.C., Identifying small molecules for regulating proteoglycan metabolism in cartilaginous tissues, Gordon Research Conferences: Cartilage biology and pathology, April 7-12 2013, Les Diablerets. 2013.

Leung Y.L., Aladin Kaderbatcha D.M., Lv F., Tam V., SUN Y., Lu W.W., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Role of fibrogenesis in control of disc degeneration, Global Spine Congress, 4-6 Apr 2013, Hong Kong. 2013.

Li Y.Y., Cheng H.W., Chow S.T., Cheung K.M.C., Chan D. and Chan B.P., Rabbit articular cartilage repair using collagen-mesenchymal stem cell microspheres., BME2012 Biomedical Engineering International Conference, 5-8 December 2012, Hong Kong.. 2012.

Lim F.L., Au Y.K., Cheah K.S.E., Chan D., Tuan R.S., Cheung K.M.C. and Leung Y.L., Cadherin 2/N-cadherin regulates notochordal cell function and intervertebral disc homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Lim F.L., Cheung K.M.C., Chan D., Tuan R.S. and Leung Y.L., Role of cadherin 2 in intervertebral disc homeostasis, Global Spine Congress, 4-6 Apr 2013, Hong Kong. 2013.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

SUN Y., Leung Y.L., TSUI Y.K., Masuda K., Kao R.Y.T., Chan D. and Cheung K.M.C., First prize for poster section: Screen of Small Molecule Compounds for Intervertebral Disc Degeneration by Chemical Genetics., East meets West Symposium, Shenzhen, China, April 8-9, 2013. 2013.

SUN Y., Leung Y.L., TSUI Y.K., Masuda K., Kao R.Y.T., Chan D. and Cheung K.M.C., Uncovering Small Chemical Molecules for Treatment of Intervertebral Disc Degeneration, Global Spine Congress, 4-6 Apr 2013, Hong Kong. 2013.

Samartzis D., Karppinen J., Bendix T., Chan D., Cheung K.M.C., Ikegawa S., Luk K.D.K., Rajasekaran S., Urban J. and Williams F., MacNab/LaRocca Award - Genetic epidemiology of disc degeneration/low back pain: international consortium, International Society for the Study of the Lumbar Spine (ISSLS) . 2013.

Samartzis D., Karppinen J.I., Chan D., Luk K.D.K. and Cheung K.M.C., Reply to the Letter by Alexiou and Voulgaris: "The Influence of Body Mass Index on Lumbar Disc Degeneration", Arthritis Rheum. 2012, Epub ahead of print.

Samartzis D., Karppinen J., Ala-Korpela M., Soininen P., Kangas A.J., Chan D., Luk K.D.K. and Cheung K.M.C., Serum metabolomic biomakers and lumbar disc degeneration., 40th Annual Meeting of the International Society for the Study of the Lumbar Spine, Scottsdale, Arizona, May 13-17, 2013.. 2013.

Samartzis D., Karppinen J.I., Ala‐Korpela M., Soininen P., Kangas A.J., Chan D., Luk K.D.K. and Cheung K.M.C., Serum metabolomic biomarkers and lumbar disc degeneration, 40th Annual Meeting of the International Society for the Study of the Lumbar Spine. Phoenix, Arizona, 2013.

Shen W., Shen Y., Chan D. and Lam Y.W., Time-lapse Imaging of Planarian Regeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agato K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating plannarian, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tan Z., Niu B., Tsang K.Y., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Tong W.Y.T., Shen W., Lam Y.W., Zhao Y., Cheng S.H., Chu P.K., Chan D., Chan G.C.F., Cheung K.M.C. and Yeung K.W.K., Functionally Replicated Bioimprint Scaffold to Support Tenocytic Differentiation of Mesenchymal Stem Cells, Orthopaedic Research Society (ORS) Annual Meeting, San Antonio, Texas, USA. 2013.

Tong W.Y.T., Shen W., Zhao Y., Cheng S.H., Chu P.K., Chan D., Chan G.C.F., Cheung K.M.C., Yeung K.W.K. and Lam Y.W., Tenogenic Differentiation of Human Mesenchymal Stem Cells on Novel Bio-Imprinted Scaffolds, 15th International Biotechnology Symposium and Exhibition (IBS 2012), Daegu, South Korea. 2012.

Tsang K.Y., Yang L., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tsang S.W., Yang Y., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes affects trabecular bone formation., Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a cadidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a Candidate Gene for Brachydactyly Type A1, encodes a Secreted Protein that Negatively Modulates Hedgehog Signaling, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang Y., Lu L.H., Wu M.H., Chan D., Cheah K.S.E., Sham M. and Cheung M.C.H., Induction of Osteo-chondroprogenitor Formation by Defined Transcription Factor-mediated Reprogramming Process, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yee F.Y.A., Lam P.Y., Dong H.G., Lam Y.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Changes in the Proteome of the Human Intervertebral Disc in Aging and Degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-rangeSOX9Enhancers in Limb Development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells, Biomaterials. 2013, 34: 3948-3961.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation., Global Spine Congress, 4-6 Apr 2013, Hong Kong. . 2013, P085.

Zhang Y., Chan W.C.W., Sakai D. and Chan D., The influence of progenitor cells in intervertebral disc degeneration and regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Chan D.

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Researcher : Chan JKM

List of Research Outputs

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Researcher : Chan KKK

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K.K. and Cheung M.C.H., Investigating the Role of SOX9 in Human Neural Stem Cells, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Chan LC

List of Research Outputs

Lam K.H., Lam W.W.L., Wong J.Y.K., Chan L.C., Kotaka M., Ling T.K.W., Jin D., Ottermann K.M. and Au S.W.N., Structural basis of FliG-FliM interaction in Helicobacter pylori., Molecular Microbiology. 2013, 88: 798-812.

Researcher : Chan W.L.

Project Title:	Quantitative analysis of TRAPPC2 and TRAPPC9 interaction
Investigator(s):	Chan WL, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

List of Research Outputs

Researcher : Chan WCW

Project Title:	Role of Endogenous Stem/Progenitor cells in the maintenance and regeneration of Intervertebral Discs
Investigator(s):	Chan WCW, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

List of Research Outputs

Chan W.C.W., Cheah K.S.E. and Chan D., Cells in the endplate contribute to the maintenance and repair of the inner Annulus fibrosus, In: W. C. W. Chan, K. S. Cheah, D. Chan, Global Spine Congress 2013.

Chan W.C.W., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, In: WCW Chan, KSE Cheah and D Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Chan W.C.W., Zhang L., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

FENG C., Chan W.C.W., Ng V.C.W., Cheah K.S.E. and Chan D., Descendents Of Lgr5-expressing Interzone Cells Are Localized To The Superficial Layer Of The Articular Cartilage, In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Feng C., Chan W.C.W., Mundlos S., Hui N.H. and Chan D., Differentiation and progression of interzone cells as progenitors of articular condrocytes in joint formaiton, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Zhang Y., Chan W.C.W., Sakai D. and Chan D., The influence of progenitor cells in intervertebral disc degeneration and regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Chan WL

Project Title:	Quantitative analysis of TRAPPC2 and TRAPPC9 interaction
Investigator(s):	Chan WL, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yu Y., Chan W.L., Shum K.T. and Tanner J.A., Tailored Selection of Nucleic Acid Aptamers against Sclerostin and Aggrecanase for Skeletal Disease Therapeutics, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Chang SK

List of Research Outputs

Chang S.K. and Shum D.K.Y., Change in NECL family expression profile in cell culture model when NECL1 is knocked down, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Chau WH

List of Research Outputs

Researcher : Chau WH

List of Research Outputs

Researcher : Cheah K.S.E.

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE, Lok S
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	The role of Snail factor in skeletal development: Physiology and Pathology
Investigator(s):	Cheah KSE, Cheung MCH, Chan D
Department:	Biochemistry
Source(s) of Funding:	CSIC / RGC Joint Research Scheme
Start Date:	07/2011

Project Title:	World Forum for Spine Research: The Intervertebral Disc - from Degeneration to Pain Multidisciplinary disc research
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Cartilage Biology & Pathology; Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Researcher : Cheah KSE

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE, Lok S
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	The role of Snail factor in skeletal development: Physiology and Pathology
Investigator(s):	Cheah KSE, Cheung MCH, Chan D
Department:	Biochemistry
Source(s) of Funding:	CSIC / RGC Joint Research Scheme
Start Date:	07/2011

Project Title:	World Forum for Spine Research: The Intervertebral Disc - from Degeneration to Pain Multidisciplinary disc research
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Cartilage Biology & Pathology; Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Au Y.K., Wynn S.A.R.A.H. .L., Szeto Y.Y., Geng Y.H., Lovell-Badge R.H., Cheung K.M.C. and Cheah K.S.E., Understanding the molecular impact of Sox9Y440X in campomelic dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012.

Chan C.C.Y., Tanner J.A., Chan D., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of Sedlin and Sedlin-like proteins in mouse yolk-sac visceral endoderm and embryo development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.C.W., Cheah K.S.E. and Chan D., Cells in the endplate contribute to the maintenance and repair of the inner Annulus fibrosus, In: W. C. W. Chan, K. S. Cheah, D. Chan, Global Spine Congress 2013.

Chan W.C.W., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, In: WCW Chan, KSE Cheah and D Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Chan W.C.W., Zhang L., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Cheng C.C.W., Niu B., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the establishment of hair follicle patterns in the developing mouse, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of hypertrophic chondrocytes , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

FENG C., CHAN C.W.W., Cheah K.S.E. and Chan D., Best Poster Award (poster entitled "Descendents of Lgr5-expressing interzone cells are localized to the superficial layer of the articular cartilage"), In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

FENG C., Chan W.C.W., Ng V.C.W., Cheah K.S.E. and Chan D., Descendents Of Lgr5-expressing Interzone Cells Are Localized To The Superficial Layer Of The Articular Cartilage, In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of Kinesin-1 mediated intracellular transport in skeletal development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Gao Y., Leung W.L., Wong S.Y.Y., Chan D., Tam P.L.P. and Cheah K.S.E., Type IIA procollagen: A Positive Regulator of Nodal Signaling during Early Embryogenesis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Faessler R. and Cheah K.S.E., Fine-tuning of notochord midline position via cell-matrix interactions, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 and Sox18 in mouse hair development, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., Sox2 regulates hair type specification and hair cycle, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Kwong W.H. and Cheah K.S.E., Smad4 Pathway Inhibits Sensory Formation in the Mouse Cochlea, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

LIU A., Wu M.H., Yan H.C., Chau K.H.B., So H., Ng A., Chan A., Cheah K.S.E., Briscoe J. and Cheung M.C.H., Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling, In: Marianne E. Bronner, Proceeding of the National Academy of Sciences of the United States of America. United States, 2013, 110: 2882-2887.

Leung K.K.H., Pelling A., Kwong W.H., Fritzsch B., Jahan I., Lovell-Badge R.H. and Cheah K.S.E., Sox2 Dosage Defines the Specification and Survival of Sensory Neurons in the Inner Ear, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Lim F.L., Au Y.K., Cheah K.S.E., Chan D., Tuan R.S., Cheung K.M.C. and Leung Y.L., Cadherin 2/N-cadherin regulates notochordal cell function and intervertebral disc homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Liu A., Wu M.H., Yan C.A.R.O.L., Chau B.O.L.T.O.N., So H.E.N.R.Y., Ng A.L.V.I.S., Chan A.L.A.N., Cheah K.S.E., Briscoe J.A.M.E.S. and Cheung M.C.H., Post-translational Regulation of Sox9 in Neural Crest Delamination, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

NG T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of the Nucleus Pulposus Cells for Degenerative Disc Disorder, Gordon Research Conference on Cartilage Biology & Pathology. Les Diablerets, Switzerland, 2013.

Ng T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of Nucleus Pulposus Cells for Degenerative Disc Disorder, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

Tai C.P., Cheung M.C.H., Bronner M.E. and Cheah K.S.E., Duplication and divergence of SoxE function during chordate evolution, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tan Z., Niu B., Tsang K.Y., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Tsang K.Y., Yang L., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tsang S.W., Yang Y., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes affects trabecular bone formation., Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a cadidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a Candidate Gene for Brachydactyly Type A1, encodes a Secreted Protein that Negatively Modulates Hedgehog Signaling, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang Y., Lu L.H., Wu M.H., Chan D., Cheah K.S.E., Sham M. and Cheung M.C.H., Induction of Osteo-chondroprogenitor Formation by Defined Transcription Factor-mediated Reprogramming Process, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

Yang W., Zhang X. and Cheah K.S.E., Research on the Genetic Basis of Human Split Hand/foot Malformation 1, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Yee F.Y.A., Lam P.Y., Dong H.G., Lam Y.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Changes in the Proteome of the Human Intervertebral Disc in Aging and Degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-rangeSOX9Enhancers in Limb Development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Cheung K.M.C., Chan D., Cheah K.S.E. and Chan B.P., Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells, Biomaterials. 2013, 34: 3948-3961.

Yuan M., Yeung C.W., Li Y.Y., Diao H., Chan D., Cheah K.S.E. and Chan B.P., Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation., Global Spine Congress, 4-6 Apr 2013, Hong Kong. . 2013, P085.

Researcher : Cheng CCW

List of Research Outputs

Cheng C.C.W., Poster Prize. Predicting the establishment of hair follicle patterns in the developing mouse, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . . 2012.

Cheng C.C.W., Niu B., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the establishment of hair follicle patterns in the developing mouse, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 and Sox18 in mouse hair development, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., Sox2 regulates hair type specification and hair cycle, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Cheng LYL

Project Title:	A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community
Investigator(s):	Cheng LYL, Tan-Un KC
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

List of Research Outputs

Tam K.T., Zhang W., Chan P.K., Cheng L.Y.L., Philipsen S., Festenstein R. and Tan-Un K.C., Identification and characterization of distal regulatory element of human NGB gene, 10th EMBL Conference August 2012 Transcription and Chromatin. 2012.

Researcher : Cheung HYZ

Project Title:	Elucidating the role of Cdk5 in endophilin B1-mediated regulation of TrkA trafficking and downstream function
Investigator(s):	Cheung HYZ
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2009
Completion Date:	02/2013

Project Title:	Regulation of autophagosome trafficking in Parkinson’s disease models
Investigator(s):	Cheung HYZ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Identification of novel autophagy regulators in neurons
Investigator(s):	Cheung HYZ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

List of Research Outputs

Cheung H.Y.Z., Endophilin B1 – at the crossroad of autophagy and endocytic trafficking, School of Biological Sciences, Nanyang Technological University, Singapore. 2012.

Cheung H.Y.Z., Regulation of autophagy induction and endocytic trafficking by endophilin B1, Department of Physiology, Life Sciences Institute Neurobiology/Aging Programme, National University of Singapore, Singapore. 2012.

Researcher : Cheung MCH

Project Title:	In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development
Investigator(s):	Cheung MCH, Zhou G
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	In vivo identification and characterization of cis-regulatory elements and upstream effectors to control Sox9 expression at the onset of neural crest specification
Investigator(s):	Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

Project Title:	Cartilage Biology & Pathology; Induction of osteo-chondroprogenitors formation during transcription factor-mediate reprogramming process
Investigator(s):	Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K.K. and Cheung M.C.H., Investigating the Role of SOX9 in Human Neural Stem Cells, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of SOX9 in human neural stem cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

LIU A., Wu M.H., Yan H.C., Chau K.H.B., So H., Ng A., Chan A., Cheah K.S.E., Briscoe J. and Cheung M.C.H., Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling, In: Marianne E. Bronner, Proceeding of the National Academy of Sciences of the United States of America. United States, 2013, 110: 2882-2887.

Liu A., Wu M.H., Yan C.A.R.O.L., Chau B.O.L.T.O.N., So H.E.N.R.Y., Ng A.L.V.I.S., Chan A.L.A.N., Cheah K.S.E., Briscoe J.A.M.E.S. and Cheung M.C.H., Post-translational Regulation of Sox9 in Neural Crest Delamination, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tai C.P., Cheung M.C.H., Bronner M.E. and Cheah K.S.E., Duplication and divergence of SoxE function during chordate evolution, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a cadidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a Candidate Gene for Brachydactyly Type A1, encodes a Secreted Protein that Negatively Modulates Hedgehog Signaling, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang Y., Lu L.H., Wu M.H., Chan D., Cheah K.S.E., Sham M. and Cheung M.C.H., Induction of Osteo-chondroprogenitor Formation by Defined Transcription Factor-mediated Reprogramming Process, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-rangeSOX9Enhancers in Limb Development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Cheung YW

List of Research Outputs

Researcher : Choi MY

List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Chong TYI

List of Research Outputs

Chong T.Y.I., Lee C.Y.L., Shiu S.Y.W. and Yao K.M., Using small molecules to induce the progressive differentiation of hESCs into pancreatic β-cell-like progenitors, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012.

Researcher : Chu KH

List of Research Outputs

Chu K.H., Zhang M., Wong Y.M.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion. , Current Trends in Biomedicine: Molecular Mechanisms of Inner Ear Development, Jaen, Spain, November 5, . 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Researcher : Chu TL

List of Research Outputs

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of hypertrophic chondrocytes , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Chun ACS

List of Research Outputs

Chun A.C.S., Kok K.H. and Jin D., REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1, Cell Cycle. 2013, 12: 365-378.

Researcher : Cui J

List of Research Outputs

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Researcher : Cui J

List of Research Outputs

Researcher : DIRKZWAGER RM

List of Research Outputs

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., The use of aptamer-conjugated nanoparticles in novel malaria diagnosis platforms, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Researcher : FAN Y

List of Research Outputs

FAN Y. and Song Y., Genetic Risk Prediction for Common Diseases Using Genetic Markers from Genome-Wide Association Studies, The Genomics of common disease 2012, September, 2012.

Fan Y. and Song Y., Improvement in detection of missing heritability and genetic risk prediction in genome-wide association studies using 1000 genomes-based imputation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : FENG C

List of Research Outputs

FENG C., CHAN C.W.W., Cheah K.S.E. and Chan D., Best Poster Award (poster entitled "Descendents of Lgr5-expressing interzone cells are localized to the superficial layer of the articular cartilage"), In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

FENG C., Chan W.C.W., Ng V.C.W., Cheah K.S.E. and Chan D., Descendents Of Lgr5-expressing Interzone Cells Are Localized To The Superficial Layer Of The Articular Cartilage, In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Feng C., Chan W.C.W., Mundlos S., Hui N.H. and Chan D., Differentiation and progression of interzone cells as progenitors of articular condrocytes in joint formaiton, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Fan Y

List of Research Outputs

FAN Y. and Song Y., Genetic Risk Prediction for Common Diseases Using Genetic Markers from Genome-Wide Association Studies, The Genomics of common disease 2012, September, 2012.

Researcher : Feng C

List of Research Outputs

Researcher : Fu C

Project Title:	Investigation of the roles of kinesins and microtubule associated proteins in spindle length control at metaphase
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	08/2011
Completion Date:	07/2012

Project Title:	the American Society for Cell Biology (ASCB) Annual Meeting; Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2012

Project Title:	Role of the interaction between psr1p and TACC/alp7p in spindle assembly
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

List of Research Outputs

Fu C., Scheffler K., Syrovaktina V., LI T. and Tran P., Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle, 2012 American Society for Cell Biology Annual Meeting. 2012.

Syrovaktina V., Fu C. and Tran P., Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects, 2012 American Society for Cell Biology Annual Meeting. 2012.

Researcher : GAO W

List of Research Outputs

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

Researcher : Gan H

List of Research Outputs

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of Kinesin-1 mediated intracellular transport in skeletal development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Xue W., Gan H., Zhu Y. and Huang J., Kinesin-1 affects chondrocytes adhesion to extracellular matrix and motility, KIF5B contributes to cell polarization during epithelial morphogenesis. 2012.

Researcher : Gao W

List of Research Outputs

Researcher : Gao Y

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D., Tam P.L.P. and Cheah K.S.E., Type IIA procollagen: A Positive Regulator of Nodal Signaling during Early Embryogenesis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Ghosh S

List of Research Outputs

Ghosh S., Liu B. and Zhou Z., Resveratrol activates SIRT1 in a Lamin A-dependent manner, Cell Cycle. 2013, 12(6): 872-6.

Liu B., Wang Z., Ghosh S. and Zhou Z., Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model, Aging Cell. 2013, 12(2): 316-8.

Liu B., Zhang L., Ghosh S. and Zhou Z., Depleting Suv39h1 methyltransferase rescues defective DNA repair and extends lifespan in progeria mouse model., Keystone Symposia Aging and Diseases of Aging (S2) 2012, Tokyo, Japan.. 2012.

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.

Researcher : Guo S

Project Title:	Investigating the role of cell-matrix interactions mediated by ß1 integrin in notochord cell polarity and cell migration
Investigator(s):	Guo S, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011
Completion Date:	03/2013

List of Research Outputs

Guo S., Best Poster Prize. Fine-tuning of notochord midline position via cell-matrix interactions, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . . 2012.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Faessler R. and Cheah K.S.E., Fine-tuning of notochord midline position via cell-matrix interactions, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : HO BS-Y

List of Research Outputs

HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 and Sox18 in mouse hair development, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., Sox2 regulates hair type specification and hair cycle, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : HO TH

List of Research Outputs

HO T.H., Jin D. and Kok K.H., Immunostimulatory function of the defective interfering RNA of measles virus, 78th Cold Spring Harbor Symposium on Quantitative Biology: Immunity and Tolerance, New York, USA, May 29- June 3, 2013.. 2013.

Ho T.H., Ng M.H., Kok K.H. and Jin D., Negative regulation of RIG-1 mediated IRF3 activation by TAK1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : HOR HH

List of Research Outputs

HOR H.H., Wang X., Hui C.C. and Sham M.H., Best Post Award: Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4 , Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanism, November 26-27, 2012. 2012.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu controls the number and cell fate of hindbrain progenitors, 46th Annual Meeting for the Japanese Society of Developmental Biologists, Matsue, Japan, May 28 – 31. 2013.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu defines the balance of hindbrain progenitor cells maintenance and differentiation, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Hor H.H., Poster Prize. Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . . 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) functions upstream of notch pathway and plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : HU X

List of Research Outputs

HU X. and Zhou Z., UHRF1 regulated hair follicle stem cells self-renewal, Gordon Research Conference on Epithelial Differentiation & Keratinization: New Frontiers and Therapeutics, Lucca, Italy. 2013.

Hu X., Understanding the biological role of UHRF1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : HUA Y

List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.

Researcher : Ho BS-Y

List of Research Outputs

Researcher : Ho DWH

Project Title:	Joint Conference of HGM 2013 and 21st International Congress of Genetics; PATHWAY ANALYSIS OF GENOME-WIDE ASSOCIATION DATA ON HEPATOCELLULAR CARCINOMA IN SOUTHERN CHINESE PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION
Investigator(s):	Ho DWH
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Ho TH

List of Research Outputs

Researcher : Hor HH

List of Research Outputs

Researcher : Hu J

List of Research Outputs

Lu X., Li S., Hu J., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Hu X

List of Research Outputs

Hu X., Understanding the biological role of UHRF1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011

Project Title:	An auto-induction protein expression system
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2012
Completion Date:	05/2013

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	the 20th Annual International Conference on Intelligent Systems for Molecular Biology Autonomous Sequential Periodic Pattern Formation from Density-dependent Motility
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Engineer bacterial cell shape
Investigator(s):	Huang J, Liu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

Project Title:	Development of subunit vaccine against Staphylococcus aureus infections
Investigator(s):	Huang J, Zhang B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

List of Research Outputs

Choi M.Y., Wang Y., Wong L.L.Y., Lu B., Chen W., Huang J., Tanner J.A. and Watt R.M., The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities, PLoS ONE. 2012, 7(8): e42561.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of Kinesin-1 mediated intracellular transport in skeletal development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Huang J., Autonomous formation of sequential periodic stripes from density-dependent motility, University of California Los Angeles, Los Angeles, California, USA, July 19, 2012. 2012.

Huang J., Autonomous formation of sequential periodic stripes from density-dependent motility, University of California San Francisco, San Francisco, California, USA, July 12, 2012 . 2012.

Huang J., Can bacteria be programmed to cure cancer? , Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, July 14, 2011 . 2012.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, University of Southern California, Los Angeles, California, USA, July 17, 2012 . 2012.

Liu M. and Huang J., KIF5B contributes to cell polarization during epithelial morphogenesis, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Lu S., Lu L.Y., Liu M., Yuan Q.J., Sham M.H., Guan X. and Huang J., PDSS2 requirements for cerebellar development and functions, Seventh Conference of the International Coenzyme Q10 Association. 2012.

Lu X., Li S., Hu J., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

WU H., Zhang H., ZHANG X., Xu H.F., Wang M., Huang J. and Zheng B., Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro., PLoS One. 2012, 7(9):: e44333.

Wang Z., XUE W., Li X., Lin R., Cui J. and Huang J., Dissect Kif5b in nuclear positioning during myogenesis: The light chain binding domain and the autoinhibitory peptide are both indispensable, Biochemical and Biophysical Research Communications. 2013, 432: 242-247.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Xue W., Gan H., Zhu Y. and Huang J., Kinesin-1 affects chondrocytes adhesion to extracellular matrix and motility, KIF5B contributes to cell polarization during epithelial morphogenesis. 2012.

YUAN Q.J., SU H.X., CHAU W.H., Ng G.C.T., Huang J., Wu W. and Lin Z.H.I.-.X.I.U., Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease, PLoS One. 2012, V8(1): e53480.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.

Researcher : Huang J.

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011

Project Title:	An auto-induction protein expression system
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2012
Completion Date:	05/2013

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	the 20th Annual International Conference on Intelligent Systems for Molecular Biology Autonomous Sequential Periodic Pattern Formation from Density-dependent Motility
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Engineer bacterial cell shape
Investigator(s):	Huang J, Liu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

Project Title:	Development of subunit vaccine against Staphylococcus aureus infections
Investigator(s):	Huang J, Zhang B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

List of Research Outputs

Researcher : Huang W

Project Title:	Quantitative characterization of mouse embryonic stem cell self- renewal, differentiation and dedifferentiation
Investigator(s):	Huang W, Huang J
Department:	Physics
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The geometry, dynamics and mechanics of mesenchymal cell pattern formation
Investigator(s):	Huang W
Department:	Physics
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	05/2013

Project Title:	2012 Annual Meeting; Quantitative characterization assisted design of novel pattern forming E coli.
Investigator(s):	Huang W
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2012

List of Research Outputs

Lu X., Li S., Hu J., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Hui CC

List of Research Outputs

HOR H.H., Wang X., Hui C.C. and Sham M.H., Best Post Award: Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4 , Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanism, November 26-27, 2012. 2012.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu controls the number and cell fate of hindbrain progenitors, 46th Annual Meeting for the Japanese Society of Developmental Biologists, Matsue, Japan, May 28 – 31. 2013.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu defines the balance of hindbrain progenitor cells maintenance and differentiation, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) functions upstream of notch pathway and plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Researcher : Hui MN

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K.K. and Cheung M.C.H., Investigating the Role of SOX9 in Human Neural Stem Cells, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of SOX9 in human neural stem cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Ikegawa S

List of Research Outputs

Samartzis D., Karppinen J., Bendix T., Chan D., Cheung K.M.C., Ikegawa S., Luk K.D.K., Rajasekaran S., Urban J. and Williams F., MacNab/LaRocca Award - Genetic epidemiology of disc degeneration/low back pain: international consortium, International Society for the Study of the Lumbar Spine (ISSLS) . 2013.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : JIA Y

List of Research Outputs

JIA Y. and Song Y., Computational Construction of the Downstream Network of Pax6 in AD Neuronal Death Model, Genomics Informatics 2012, Wellcome Trust, UK. 2012.

Jia Y., Chau W.H., Zhang Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Jia Y

List of Research Outputs

JIA Y. and Song Y., Computational Construction of the Downstream Network of Pax6 in AD Neuronal Death Model, Genomics Informatics 2012, Wellcome Trust, UK. 2012.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis
Investigator(s):	Jin D, Ching YP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Identification and characterization of the cellular targets of miR-BART5, an Epstein-Barr virus-encoded microRNA
Investigator(s):	Jin D, Kok KH, Tsao GSW
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Roles of dsRNA-binding protein PACT in RIG-I dependent innate antiviral immunity
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Modulation of cell signalling by human coronavirus HKU1 S and M proteins
Investigator(s):	Jin D, Woo PCY
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Kinetochore localization and function of a structural component of the nuclear pore complex
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2013

Project Title:	Construction of miR-BART microRNA-deficient Epstein-Barr viruses in bacterial artificial chromosomes using recombineering in E. coli and characterization of recombinant viruses in nasopharyngeal epithelial cells
Investigator(s):	Jin D, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Molecular mechanisms of innate antiviral response
Investigator(s):	Jin D, Kok KH, Lau ASY, Sham MH, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

Project Title:	Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis
Investigator(s):	Jin D, Tang VHM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2012

Project Title:	Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013

Project Title:	Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells
Investigator(s):	Jin D, Huang J, Tang VHM
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription
Investigator(s):	Jin D, Zheng B, Zhou J, Tang VHM
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Anti-hepatitis B virus activity of Resveratrol and mechanism of action
Investigator(s):	Jin D, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Molecular Mechanisms of Innate Immunity
Investigator(s):	Jin D, Lu L, Lau ASY, Tu W
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	06/2013

Project Title:	16th International Conference on Human Retrovirology: HTLV and Related Viruses; Suppression of type I interferon production by human T-cell leukemia virus type 1 oncoprotein Tax
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Understanding innate immune response to influenza A viruses using reverse genetics and TALEN technology, Joint Research Conference on Molecular Oncology, Guangzhou, China. 2012.

Chun A.C.S., Kok K.H. and Jin D., REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1, Cell Cycle. 2013, 12: 365-378.

HO T.H., Jin D. and Kok K.H., Immunostimulatory function of the defective interfering RNA of measles virus, 78th Cold Spring Harbor Symposium on Quantitative Biology: Immunity and Tolerance, New York, USA, May 29- June 3, 2013.. 2013.

Ho T.H., Ng M.H., Kok K.H. and Jin D., Negative regulation of RIG-1 mediated IRF3 activation by TAK1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Jin D., Shi Y.B. and Wu T.C., In memoriam: Kuan-Teh Jeang, MD PhD (1958–2013), Cell & Bioscience. 2013, 3: 13.

Jin D., Special tribute to KT Jeang , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013. . 2013.

Jin D., Kok K.H., Tang V.H.M., LUI P.Y. and Chan C.P., Suppression of type I interferon production by human T-cell leukemia virus type 1 Tax oncoprotein , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013.

Kok K.H., Lei T. and Jin D., An EBV microRNA targets DICE1 tumor suppressor gene , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Kok K.H., Au S.W.N. and Jin D., Immunostimulatory function of measles virus defective interfering RNA, The 3rd Cross Straight Immunology Conference and the 3rd CMI Symposium on Immunology. University of Science and Technology of China, Hefei, Anhui, China, December 1-2, 2012.. 2012.

Kok K.H., Tang V.H.M. and Jin D., ‘One Health’ for the people of Hong Kong and the world, Science China Life Sciences. 2012.

Kong K.Y., Tang V.H.M., Huang Z., Hinnebusch A.G., Jin D. and Wong C.M., Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal slicing efficiency, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2013. 2012.

LAM H.C., Jin D. and Song Y., Genome wide linkage Association analysis reveals PTPN21 contributes to Elk-1 dependent NRG3 expression, enhances neuronal survival in embryonic cortical neurons , Neurogenesis (J7), New Mexixo, USA, 02/2013.

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Lam K.H., Lam W.W.L., Wong J.Y.K., Chan L.C., Kotaka M., Ling T.K.W., Jin D., Ottermann K.M. and Au S.W.N., Structural basis of FliG-FliM interaction in Helicobacter pylori., Molecular Microbiology. 2013, 88: 798-812.

Lo A.K.F., Dawson C.W., Jin D. and Lo K.W., The pathological roles of BART miRNAs in nasopharyngeal carcinoma., Journal of Pathology. 2012, 227: 392-403.

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

YUEN K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores cellular proapoptotic protein PUMA expression by silencing Epstein-Barr virus-encoded miR-BART5 in nasopharyngeal carcinoma cells , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Researcher : Jin G

Project Title:	MT1-MMP in the regulation of stem cell niches
Investigator(s):	Jin G, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

List of Research Outputs

Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Researcher : Jin G

List of Research Outputs

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Researcher : Jin Y

Project Title:	Cell-to-cell coupling mediated seamless genetic engineering
Investigator(s):	Jin Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	07/2010

Researcher : KINGHORN AB

List of Research Outputs

KINGHORN A.B. and Tanner J.A., The genetics of SELEX, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Kinghorn A.B. and Tanner J.A., Selex in silico, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Researcher : KWAN PY

List of Research Outputs

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized chondroitinase ABC I and II on chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 68. 2013.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized Chondroitinase ABC I and II on Chitosan Beads Improve Axonal Regrowth in CSPG-Enriched Astrocyte Culture, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P41. 2013.

Researcher : Kao PYP

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Kinghorn AB

List of Research Outputs

KINGHORN A.B. and Tanner J.A., The genetics of SELEX, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Kinghorn A.B. and Tanner J.A., Selex in silico, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Researcher : Kok KH

Project Title:	Dominant negative role of a naturally-occurring alternatively spliced variant of TAR-binding protein in miRNA-mediated gene silencing
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011

Project Title:	Inhibition of RIG-I-dependent innate immunity by herpes simplex virus type 1 Us11 protein
Investigator(s):	Kok KH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Characterization of the interferon-antagonizing activity of NSs protein encoded by severe febrile and thrombocytopenic syndrome virus (SFTSV), a newly identified phlebovirus associated with an emerging infectious disease
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Modulation of RIG-I virus sensor by an Esptein-Barr virus-encoded microRNA
Investigator(s):	Kok KH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2012

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	International Congress on Oncogenic Herpesviruses and Associated Diseases; An EBV microRNA targets DICE1 tumor suppressor gene
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2012

Project Title:	Roles of PACT in the induction of type I interferon by measles virus defective interring RNA
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Role of PACT in host antiviral defence against influenza A virus
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Understanding innate immune response to influenza A viruses using reverse genetics and TALEN technology, Joint Research Conference on Molecular Oncology, Guangzhou, China. 2012.

Chun A.C.S., Kok K.H. and Jin D., REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1, Cell Cycle. 2013, 12: 365-378.

HO T.H., Jin D. and Kok K.H., Immunostimulatory function of the defective interfering RNA of measles virus, 78th Cold Spring Harbor Symposium on Quantitative Biology: Immunity and Tolerance, New York, USA, May 29- June 3, 2013.. 2013.

Ho T.H., Ng M.H., Kok K.H. and Jin D., Negative regulation of RIG-1 mediated IRF3 activation by TAK1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Jin D., Kok K.H., Tang V.H.M., LUI P.Y. and Chan C.P., Suppression of type I interferon production by human T-cell leukemia virus type 1 Tax oncoprotein , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013.

Kok K.H., Lei T. and Jin D., An EBV microRNA targets DICE1 tumor suppressor gene , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Kok K.H., Au S.W.N. and Jin D., Immunostimulatory function of measles virus defective interfering RNA, The 3rd Cross Straight Immunology Conference and the 3rd CMI Symposium on Immunology. University of Science and Technology of China, Hefei, Anhui, China, December 1-2, 2012.. 2012.

Kok K.H., Tang V.H.M. and Jin D., ‘One Health’ for the people of Hong Kong and the world, Science China Life Sciences. 2012.

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

YUEN K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores cellular proapoptotic protein PUMA expression by silencing Epstein-Barr virus-encoded miR-BART5 in nasopharyngeal carcinoma cells , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Researcher : Kong KY

List of Research Outputs

Kong K.Y., Tang V.H.M., Huang Z., Hinnebusch A.G., Jin D. and Wong C.M., Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal slicing efficiency, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2013. 2012.

Researcher : Kudelko MA

Project Title:	Comparative proteomic study of normal and dysplasic hypertrophic cartilage to unravel in vivo specific components involved in skeletal dysplasias
Investigator(s):	Kudelko MA, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2013

Researcher : Kwok CTD

List of Research Outputs

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Researcher : Kwok LF

List of Research Outputs

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized chondroitinase ABC I and II on chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 68. 2013.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized Chondroitinase ABC I and II on Chitosan Beads Improve Axonal Regrowth in CSPG-Enriched Astrocyte Culture, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P41. 2013.

Researcher : Kwong WH

Project Title:	The role of Smad4 in cochlear development in mouse
Investigator(s):	Kwong WH, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011

List of Research Outputs

Kwong W.H. and Cheah K.S.E., Smad4 Pathway Inhibits Sensory Formation in the Mouse Cochlea, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Leung K.K.H., Pelling A., Kwong W.H., Fritzsch B., Jahan I., Lovell-Badge R.H. and Cheah K.S.E., Sox2 Dosage Defines the Specification and Survival of Sensory Neurons in the Inner Ear, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : LAM HC

List of Research Outputs

LAM H.C., Jin D. and Song Y., Genome wide linkage Association analysis reveals PTPN21 contributes to Elk-1 dependent NRG3 expression, enhances neuronal survival in embryonic cortical neurons , Neurogenesis (J7), New Mexixo, USA, 02/2013.

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : LI J

List of Research Outputs

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications. , Mathematics, computer and life sciences interdisciplinary research young scholars forum, University of Chinese Academy of Sciences, Beijing, China, 18 May 2013.

LI J., Sham P.C. and Wang J.J., Genetic variants representation, annotation and prioritization in the post-GWAS era, Cell Research. 2012, 22: 1505–1508.

Li J. and Wang J.J., Discovery of functional genetic variants in the post-GWAS era, IEEE International Conference on Systems Biology, Xi’an, China, Aug 18-20. 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., FaSD: a efficient model to detect SNPs for NGS data., 17th Annual International Conference on Research in Computational Molecular Biology, Tsinghua University, Beijing, 7-10 April, 2013.. 2013.

Researcher : LI T

List of Research Outputs

Fu C., Scheffler K., Syrovaktina V., LI T. and Tran P., Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle, 2012 American Society for Cell Biology Annual Meeting. 2012.

Researcher : LIN R

List of Research Outputs

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

Wang Z., XUE W., Li X., Lin R., Cui J. and Huang J., Dissect Kif5b in nuclear positioning during myogenesis: The light chain binding domain and the autoinhibitory peptide are both indispensable, Biochemical and Biophysical Research Communications. 2013, 432: 242-247.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Researcher : LIU Y

List of Research Outputs

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Researcher : LUI LHE

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Researcher : LUI PY

List of Research Outputs

Jin D., Kok K.H., Tang V.H.M., LUI P.Y. and Chan C.P., Suppression of type I interferon production by human T-cell leukemia virus type 1 Tax oncoprotein , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013.

Researcher : LUI WT

List of Research Outputs

Wong N.S. and LUI W.T., The Potential Role Of Simian Virus 40 PolyA Sequence To Mediate Stress-inducible mRNA Translation, Experimental Biology 2013.

Researcher : Lam HC

List of Research Outputs

Researcher : Lam KY

List of Research Outputs

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Researcher : Lam VMS

Project Title:	18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Project Title:	HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2002

Project Title:	7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Researcher : Lam YL

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic function in the central vestibular circuitry. Int’l Conference of Physiological Sciences 2012, The Chinese Association for Physiological Sciences Symposium - Synaptic Function and Plasticity in Health and Disease. Acta Physiologica Sinica . 2012, 64: 11.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Society Neuroscience Abstract (USA), 845.23/C18. 2012.

Ma C.W., Lam Y.L., Cham W.C., Han L., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic function of the central vestibular system, Gordon Research Conferences (Proteoglycans), Andover, USA. Jul 8-13. 2012.

Researcher : Lam YL

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Researcher : Lee M

Project Title:	Investigation of Bacterial Anticancer Therapy by Applying Evolutionary Experiment
Investigator(s):	Lee M, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011
Completion Date:	05/2013

List of Research Outputs

Lee M., Carl Storm International Diversity Fellowship, Gordon Research Conference on Microbial Toxins & Pathogenicity, Waterville Valley, NH, USA. 2012.

Researcher : Lei IL

List of Research Outputs

Lei I.L., Liu L., Sham M.H. and Wang Z., SWI/SNF in cardiac progenitor cell differentiation., Journal of Cellular Biochemistry. 2013, Epub ahead of print: doi: 10.1002/jcb.24570.

Researcher : Lei T

Project Title:	A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis
Investigator(s):	Lei T, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

List of Research Outputs

Kok K.H., Lei T. and Jin D., An EBV microRNA targets DICE1 tumor suppressor gene , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Researcher : Leong JCY

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Leung C

List of Research Outputs

Leung C., Zhang M., SIT H.M. and Sham M.H., Sox10 regulates enteric neural crest cell migration in the developing gut., 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

SIT H.M., Zhang M., Leung C. and Sham M.H., The role of Sox10 in enteric neural crest cellmigration, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Sit H.M., Zhang M., Leung C. and Sham M.H., The role of SOX10 in enteric neural crest cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Leung HY

List of Research Outputs

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

Researcher : Leung KKH

List of Research Outputs

HO B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 and Sox18 in mouse hair development, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., Sox2 regulates hair type specification and hair cycle, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Leung K.K.H., Nomenclature and Breeding Schemes of Mouse Mutants, Laboratory Animal Unit, The University of Hong Kong. 2012.

Leung K.K.H., Pelling A., Kwong W.H., Fritzsch B., Jahan I., Lovell-Badge R.H. and Cheah K.S.E., Sox2 Dosage Defines the Specification and Survival of Sensory Neurons in the Inner Ear, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Leung MH

List of Research Outputs

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Researcher : Leung WL

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D., Tam P.L.P. and Cheah K.S.E., Type IIA procollagen: A Positive Regulator of Nodal Signaling during Early Embryogenesis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Leung WYG

List of Research Outputs

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Researcher : Li J

List of Research Outputs

LI J., Sham P.C. and Wang J.J., Genetic variants representation, annotation and prioritization in the post-GWAS era, Cell Research. 2012, 22: 1505–1508.

Li J. and Wang J.J., Discovery of functional genetic variants in the post-GWAS era, IEEE International Conference on Systems Biology, Xi’an, China, Aug 18-20. 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

Researcher : Li L

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Researcher : Li X

List of Research Outputs

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Researcher : Lin R

List of Research Outputs

Researcher : Lin R

List of Research Outputs

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Keystone Symposia: Aging and Diseases of Aging (S2); Depleting Suv39h1 methyltransferase rescues defective DNA repair and extends lifespan in progeria mouse model
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

Ghosh S., Liu B. and Zhou Z., Resveratrol activates SIRT1 in a Lamin A-dependent manner, Cell Cycle. 2013, 12(6): 872-6.

Liu B., ZHOU S., Liu X., Zhou K., Zhang F. and Zhou Z., Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model., BMC Longevity & Healthspan. 2013.

Liu B. and Zhou Z., Activation of SIRT1 by resveratrol requires lamin A, Aging (Albany NY). 2013, 5(2): 94-5.

Liu B., YIP K.H.R. and Zhou Z., Chromatin Remodeling, DNA Damage Repair and Aging, Current Genomics. 2012, 13: 533-547.

Liu B., Wang Z., Ghosh S. and Zhou Z., Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model, Aging Cell. 2013, 12(2): 316-8.

Liu B., Zhang L., Ghosh S. and Zhou Z., Depleting Suv39h1 methyltransferase rescues defective DNA repair and extends lifespan in progeria mouse model., Keystone Symposia Aging and Diseases of Aging (S2) 2012, Tokyo, Japan.. 2012.

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.

Liu B. and Zhou Z., Resveratrol rescues Sirt1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria., EMBL Conference: Stem Cells in Cancer and Regenerative Medicine 2012, Heidelberg, Germany.. 2012.

Liu B., SIRT1, end of the story in aging., International Symposium of AAAR (Asian Association of Aging Research) 2012, Fukuoka, Japan.. 2012.

Liu B. and Zhou Z., SIRT1, end of the story in aging., International Symposium of AAAR 2012, Fukuoka, Japan.. 2012.

Researcher : Liu C

Project Title:	Evolution of a synthetic pattern formation system
Investigator(s):	Liu C, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	02/2013

List of Research Outputs

Liu C., Hong Kong Young Scientist Award, 青年科学家奖, Hong Kong Institution of Science . 香港科学会, 2012.

Liu C., Li Ka Shing Prize, The University of Hong Kong. 2012.

Researcher : Liu M

List of Research Outputs

Liu M. and Huang J., KIF5B contributes to cell polarization during epithelial morphogenesis, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Lu S., Lu L.Y., Liu M., Yuan Q.J., Sham M.H., Guan X. and Huang J., PDSS2 requirements for cerebellar development and functions, Seventh Conference of the International Coenzyme Q10 Association. 2012.

Researcher : Liu Y

List of Research Outputs

Researcher : Lovell-Badge RH

List of Research Outputs

Au Y.K., Wynn S.A.R.A.H. .L., Szeto Y.Y., Geng Y.H., Lovell-Badge R.H., Cheung K.M.C. and Cheah K.S.E., Understanding the molecular impact of Sox9Y440X in campomelic dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012.

Cheng C.C.W., Niu B., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the establishment of hair follicle patterns in the developing mouse, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Leung K.K.H., Pelling A., Kwong W.H., Fritzsch B., Jahan I., Lovell-Badge R.H. and Cheah K.S.E., Sox2 Dosage Defines the Specification and Survival of Sensory Neurons in the Inner Ear, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

Researcher : Lu S

List of Research Outputs

Lu S., Lu L.Y., Liu M., Yuan Q.J., Sham M.H., Guan X. and Huang J., PDSS2 requirements for cerebellar development and functions, Seventh Conference of the International Coenzyme Q10 Association. 2012.

Researcher : Lu X

List of Research Outputs

Lu X., Li S., Hu J., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Lui YY

List of Research Outputs

Wong M.K., Lui Y.Y., Chan Y.S. and Shum D.K.Y., Chondroitin sulfate moieties control motor neuron migration in the rat embryonic hindbrain, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 67. 2013.

Researcher : Mak ACY

List of Research Outputs

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

Researcher : Melhado IG

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Ng GCT

List of Research Outputs

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

YUAN Q.J., SU H.X., CHAU W.H., Ng G.C.T., Huang J., Wu W. and Lin Z.H.I.-.X.I.U., Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease, PLoS One. 2012, V8(1): e53480.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

Researcher : Ng MH

List of Research Outputs

Ho T.H., Ng M.H., Kok K.H. and Jin D., Negative regulation of RIG-1 mediated IRF3 activation by TAK1, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Ng VCW

List of Research Outputs

FENG C., Chan W.C.W., Ng V.C.W., Cheah K.S.E. and Chan D., Descendents Of Lgr5-expressing Interzone Cells Are Localized To The Superficial Layer Of The Articular Cartilage, In: Amy C Feng, Wilson CW Chan, Vivian CW Ng, Jia Chi Yeo, Sigmar Stricker, Kathy Cheah, Manuel Koch, Stefan Mundlos, Huck Hui Ng, and Danny Chan, Gordon Research Conference 2013: Cartilage Biology & Pathology - Formation, Structure, Function, and Regeneration. 2013.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agato K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating plannarian, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Ngan WL

List of Research Outputs

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Researcher : Ni Y

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Ni Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2012

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Cheng C.C.W., Niu B., Lovell-Badge R.H., Hwa T.T. and Cheah K.S.E., Predicting the establishment of hair follicle patterns in the developing mouse, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tan Z., Niu B., Tsang K.Y., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Osorio Da Silva LA

List of Research Outputs

Osorio Da Silva L.A., Wu X. and Zhou Z., Understanding the Biological Role of Isthmin during Mouse Development and Homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Osorio Da Silva L.A. and Zhou Z., Understanding the biological role of isthmin in mouse development and homeostasis, HKSDB – From Embryology to Disease Mechanism – In honour of Patrick Tam – 60 years & Still Gastrulating, Hong Kong. 2012.

Researcher : Qian C

Project Title:	Structural and Functional Analysis of Oncoprotein UHRF1
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	Structural and Mechanistic Analysis of Human SMARCAL1
Investigator(s):	Qian C, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2011

Project Title:	Structural and Mechanistic Characterization of XPA/RPA complex in DNA recognition
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Structural Basis for the interaction of human Timeless with Parp1
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

Xie S., Jean J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Qin J

List of Research Outputs

Qin J., Li M.J., Wang P. and Wang J.J., Integrative approach for Omic data analysis and gene regulatory network construction, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

Researcher : SHEA GKH

List of Research Outputs

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Researcher : SHUM KT

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Ao K.L., Shum K.T. and Tanner J.A., Investigation of the protein/Polyphosphate binding interface: mutational studies on mycobacterium tuberculosis polyphosphate kinase 2 (PPK2), 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Yu Y., Chan W.L., Shum K.T. and Tanner J.A., Tailored Selection of Nucleic Acid Aptamers against Sclerostin and Aggrecanase for Skeletal Disease Therapeutics, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : SIT HM

List of Research Outputs

Leung C., Zhang M., SIT H.M. and Sham M.H., Sox10 regulates enteric neural crest cell migration in the developing gut., 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

SIT H.M., Zhang M., Leung C. and Sham M.H., The role of Sox10 in enteric neural crest cellmigration, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Sit H.M., Zhang M., Leung C. and Sham M.H., The role of SOX10 in enteric neural crest cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	Enteric neural crest cell migration in the developing gut: Molecular and cellular analyses of a Sox10 mouse mutant
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated Branchio-Oto-Renal syndrome.
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Molecular Mechanisms of Inner Ear Development; Sox10 is essential for neural crest invasion in cochlea-vestibular ganglion
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2012

Project Title:	The role of Suppressor of fused (Sufu) in mediating hedgehog and beta-catenin signaling in the hindbrain
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	The roles of Irx3 and Irx5 genes in mammalian inner ear morphogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

List of Research Outputs

Bondurand N. and Sham M.H., The role of SOX10 during enteric nervous system development., Developmental Biology. 2013, Epub ahead of print.

Chu K.H., Zhang M., Wong Y.M.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion. , Current Trends in Biomedicine: Molecular Mechanisms of Inner Ear Development, Jaen, Spain, November 5, . 2012.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Best Post Award: Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4 , Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanism, November 26-27, 2012. 2012.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu controls the number and cell fate of hindbrain progenitors, 46th Annual Meeting for the Japanese Society of Developmental Biologists, Matsue, Japan, May 28 – 31. 2013.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu defines the balance of hindbrain progenitor cells maintenance and differentiation, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) functions upstream of notch pathway and plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Lei I.L., Liu L., Sham M.H. and Wang Z., SWI/SNF in cardiac progenitor cell differentiation., Journal of Cellular Biochemistry. 2013, Epub ahead of print: doi: 10.1002/jcb.24570.

Leung C., Zhang M., SIT H.M. and Sham M.H., Sox10 regulates enteric neural crest cell migration in the developing gut., 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Lu S., Lu L.Y., Liu M., Yuan Q.J., Sham M.H., Guan X. and Huang J., PDSS2 requirements for cerebellar development and functions, Seventh Conference of the International Coenzyme Q10 Association. 2012.

NG T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of the Nucleus Pulposus Cells for Degenerative Disc Disorder, Gordon Research Conference on Cartilage Biology & Pathology. Les Diablerets, Switzerland, 2013.

Ng T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of Nucleus Pulposus Cells for Degenerative Disc Disorder, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

SIT H.M., Zhang M., Leung C. and Sham M.H., The role of Sox10 in enteric neural crest cellmigration, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Sham M.H., Member of the Academic Editorial Board, PLoS ONE. PLoS, 2012.

Sham M.H., Review Editor, Frontiers in Autonomic Neuroscience. Frontiers Editorial Office, 2012.

Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion. , Current Trends in Biomedicine: Molecular Mechanisms of Inner Ear Development, Jaen, Spain, November 5, . 2012.

Sham M.H., Sox10 regulates enteric neural crest cell migration in the developing gut, International Society of Developmental Biologists 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Sham M.H., Special Issue: Development of the Enteric Nervous System, , Developmental Biology. 2013.

Sham M.H., Special Issue: Development of the Enteric Nervous System, Developmental Biology. 2013.

Sham M.H., Suppressor of fused (Sufu) mediates Hedgehog and Notch signaling in hindbrain neurogenesis, School of Life Sciences, Wuhan University. 2013.

Sham M.H., Suppressor of fused (Sufu) mediates Hedgehog and Notch signaling in hindbrain neurogenesis, The University of Science and Technology of China. 2013.

Sit H.M., Zhang M., Leung C. and Sham M.H., The role of SOX10 in enteric neural crest cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Zhang H., Wong E.Y.M., Tsang S.L. and Sham M.H., The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated branchio-Oto-Renal syndrome, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12. 2012.

Researcher : Shea GKH

List of Research Outputs

Researcher : Shen Y

List of Research Outputs

Shen W., Shen Y., Chan D. and Lam Y.W., Time-lapse Imaging of Planarian Regeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agato K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating plannarian, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	10/2007

Project Title:	Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways
Investigator(s):	Shum DKY, Ip MSM, Chan CH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2008

Project Title:	From bone marrow stromal cells to Schwann cells an in vitro route to specification
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY, Chan YS, Tam KW
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	07/2011

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2011

Project Title:	Proheparanase and AMPA receptor trafficking in synaptic plasticity
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	42nd Annual Meeting of Society for Neuroscience; Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

List of Research Outputs

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF regulates plasticity in spatial coding. International Society of Neurochemistry Symposium on Nervous Systems and Diseases : Models and Mechanisms , 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation, Soc. Neuroscience Abstract (USA), 735.11/A55. 2012.

Cai S., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of human neural crest stem cells from human induced pluripotent stem cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Chan Y.S., Li C., Han L., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations, Society Neuroscience Abstract (USA), 470.12/DD17. 2012.

Chang S.K. and Shum D.K.Y., Change in NECL family expression profile in cell culture model when NECL1 is knocked down, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized chondroitinase ABC I and II on chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 68. 2013.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized Chondroitinase ABC I and II on Chitosan Beads Improve Axonal Regrowth in CSPG-Enriched Astrocyte Culture, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P41. 2013.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Ma C.W., Zhang F.X., Lai C.H., Lai S.K., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations, Journal of Comparative Neurology. 2013, 521: 612-625.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic function in the central vestibular circuitry. Int’l Conference of Physiological Sciences 2012, The Chinese Association for Physiological Sciences Symposium - Synaptic Function and Plasticity in Health and Disease. Acta Physiologica Sinica . 2012, 64: 11.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Society Neuroscience Abstract (USA), 845.23/C18. 2012.

Ma C.W., Lam Y.L., Cham W.C., Han L., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic function of the central vestibular system, Gordon Research Conferences (Proteoglycans), Andover, USA. Jul 8-13. 2012.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior system, Abstracts of 8th Int’l Symp. on Healthy Aging: 70. 2013.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 70. 2013.

Ma C.W., Lai C.H., Chow B.K.C., Shum D.K.Y. and Chan Y.S., Topography of inferior olivary neurons that encode canal and otolith inputs, Cerebellum. 2013, 12: 322-324.

Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus, 11^th Biennial Meeting of Asia-Pacific Society of Neurochemistry Journal of Neurochemistry 123 (Suppl. 1): 80. 2012.

Shi W., Hu H., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of central vestibular synapses and vestibular behaviors in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 60. 2013.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned Chitosan Nanofibers for Culturing Schwann Cells to Guide Axonal Growth, 8th Int’l Symp. on Healthy Aging: How to age with finesse:P20. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The Effects of Chondroitinase ABC Digestion Products on Neurite Growth: Saccharide Length and Sulphation Pattern, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P3. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The effects of chondroitinase ABC digestion products on neurite growth: Saccharide length and sulphation pattern, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 58. 2013.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: therapeutic potential and developmental origin, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy with oligodendrocyte precursor derivation from bone marrow stromal cells, Soc. Neuroscience Abstract (USA), 632.06/A6. 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursor cells from bone marrow stromal cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers for culturing oriented Schwann cells to guide axonal growth, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Chitosan fibers for culturing aligned Schwann cells for nerve regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Wong M.K., Lui Y.Y., Chan Y.S. and Shum D.K.Y., Chondroitin sulfate moieties control motor neuron migration in the rat embryonic hindbrain, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 67. 2013.

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase activity enhances MMP-7 dependent syndecan-1 shedding in the airway, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Shum KT

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Researcher : Sit HM

List of Research Outputs

Researcher : Siu KL

List of Research Outputs

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Siu YT

List of Research Outputs

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

Researcher : Smith DK

Project Title:	Patterns in proteins with unusual flexibility profiles
Investigator(s):	Smith DK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	08/2002

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	In silico identification of genetic variations that affect resistance to influenza A virus infection
Investigator(s):	Song Y, To KKW, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2011

Project Title:	Uncovering the mechanism of oncoviruses in causing cancers using pluripotency signatures
Investigator(s):	Song Y, Zhu H
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice
Investigator(s):	Song Y, Cheah KSE, Sham PC
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Annual meeting of the American Society of Human Genetics, 2012; Novel sequence motif regulates pluripotency
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2012

Project Title:	Analysis of exome sequencing of APOEε4 negative Alzheimer’s disease case/control subjects in southern Chinese
Investigator(s):	Song Y, Sham PC, Chu LW
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013

List of Research Outputs

BAO S., Zhou X. and Song Y., Integrating genetic linkage analysis and computational prioritization in identifying host genetic factors response to influenza A virus infection, The 62nd Annual Meeting of the American Society of Human Genetics. 2012.

BAO S., Niu G. and Song Y., Novel sequence motif regulates pluripotency, Annual meeting of the American Society of Human Genetics, 2012; . 2012.

FAN Y. and Song Y., Genetic Risk Prediction for Common Diseases Using Genetic Markers from Genome-Wide Association Studies, The Genomics of common disease 2012, September, 2012.

Fan Y. and Song Y., Improvement in detection of missing heritability and genetic risk prediction in genome-wide association studies using 1000 genomes-based imputation, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

JIA Y. and Song Y., Computational Construction of the Downstream Network of Pax6 in AD Neuronal Death Model, Genomics Informatics 2012, Wellcome Trust, UK. 2012.

Jia Y., Chau W.H., Zhang Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

LAM H.C., Jin D. and Song Y., Genome wide linkage Association analysis reveals PTPN21 contributes to Elk-1 dependent NRG3 expression, enhances neuronal survival in embryonic cortical neurons , Neurogenesis (J7), New Mexixo, USA, 02/2013.

Lam H.C., Siu K.L., Chau W.H., Ng M.H., Ng G.C.T., Jin D. and Song Y., Protein tyrosine phosphatase non-receptor 21 (PTPN21) contributes to Elk-1 dependent NRG3 transcription in mice cortical neuron model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Li M., Kwan S.H., Bao S., Yang W., Ho S.L., Song Y. and Sham P.C., Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies, PLos Genet. 2013, 9(1): e1003143.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

Zhou J., To K.K.W., Dong H.U.I., Cheng Z.H.O.N.G.-.S.H.A.N., Lau C.Y., Fan Y.A.N.-.H.U.I., Song Y., Tse H., Chan K.H., Zheng B., Zhao G.U.O.-.P.I.N.G. and Yuen K.Y., A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection, Journal of Infectious Diseases. 2012, 206: 495-503.

Researcher : Sze KL

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Szeto YY

Project Title:	Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear
Investigator(s):	Szeto YY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Au Y.K., Wynn S.A.R.A.H. .L., Szeto Y.Y., Geng Y.H., Lovell-Badge R.H., Cheung K.M.C. and Cheah K.S.E., Understanding the molecular impact of Sox9Y440X in campomelic dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

Szeto Y.Y., Poster Prize. Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . . 2012.

Researcher : TUNG WT

List of Research Outputs

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned Chitosan Nanofibers for Culturing Schwann Cells to Guide Axonal Growth, 8th Int’l Symp. on Healthy Aging: How to age with finesse:P20. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers for culturing oriented Schwann cells to guide axonal growth, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Chitosan fibers for culturing aligned Schwann cells for nerve regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Researcher : Tai CP

Project Title:	Conservation of chordate SOXE protein function in chondrogenesis
Investigator(s):	Tai CP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012

List of Research Outputs

Tai C.P., Cheung M.C.H., Bronner M.E. and Cheah K.S.E., Duplication and divergence of SoxE function during chordate evolution, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Tam JWO

Project Title:	14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis
Investigator(s):	Tam JWO
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Researcher : Tam KW

List of Research Outputs

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized Chondroitinase ABC I and II on Chitosan Beads Improve Axonal Regrowth in CSPG-Enriched Astrocyte Culture, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P41. 2013.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned Chitosan Nanofibers for Culturing Schwann Cells to Guide Axonal Growth, 8th Int’l Symp. on Healthy Aging: How to age with finesse:P20. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The Effects of Chondroitinase ABC Digestion Products on Neurite Growth: Saccharide Length and Sulphation Pattern, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P3. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Chitosan fibers for culturing aligned Schwann cells for nerve regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Researcher : Tam PLP

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D., Tam P.L.P. and Cheah K.S.E., Type IIA procollagen: A Positive Regulator of Nodal Signaling during Early Embryogenesis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Tan Z

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tan Z., Niu B., Tsang K.Y., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Tang HC

List of Research Outputs

Tsang K.Y., Yang L., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Tang VHM

Project Title:	Anti-HBV potential of Metformin and the mechanism of action
Investigator(s):	Tang VHM, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2012
Completion Date:	02/2013

Project Title:	16th International Conference on Human Retrovirology HTLV and Related Viruses – HTLV 2013; Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases
Investigator(s):	Tang VHM
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Jin D., Kok K.H., Tang V.H.M., LUI P.Y. and Chan C.P., Suppression of type I interferon production by human T-cell leukemia virus type 1 Tax oncoprotein , 16th International Conference on Human Retrovirology: HTLV and Related Viruses. Montreal, Quebec, Canada, June 26-30, 2013.

Kok K.H., Tang V.H.M. and Jin D., ‘One Health’ for the people of Hong Kong and the world, Science China Life Sciences. 2012.

Kong K.Y., Tang V.H.M., Huang Z., Hinnebusch A.G., Jin D. and Wong C.M., Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal slicing efficiency, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2013. 2012.

Tang V.H.M., 16th International Conference on Human Retrovirology Young Investigator Travel Award, International Retrovirology Association. 2013.

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

Tang V.H.M., Young Investigator Travel Award, International Retrovirology Association. 2013.

Tang V.H.M., Young Scientists Fund, National Natural Science Foundation of China (NSFC). 国家自然科学基金, 2012.

YUEN K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores cellular proapoptotic protein PUMA expression by silencing Epstein-Barr virus-encoded miR-BART5 in nasopharyngeal carcinoma cells , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Researcher : Tanner J.A.

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis
Investigator(s):	Tanner JA, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013

Project Title:	IATI-BioMed Israel 2013; Nucleic acid aptamers for malaria diagnosis – discovery, structure and application
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis
Investigator(s):	Tanner JA, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013

Project Title:	IATI-BioMed Israel 2013; Nucleic acid aptamers for malaria diagnosis – discovery, structure and application
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

AO K.L., LUI L.H.E., Li L., SHUM K.T. and Tanner J.A., Polyphosphate regulates interleukin-11 levels of SaOS-2 cells, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Ao K.L., Shum K.T. and Tanner J.A., Investigation of the protein/Polyphosphate binding interface: mutational studies on mycobacterium tuberculosis polyphosphate kinase 2 (PPK2), 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Chan C.C.Y., Tanner J.A., Chan D., Luk K.D.K. and Cheah K.S.E., Dosage-dependent requirement of Sedlin and Sedlin-like proteins in mouse yolk-sac visceral endoderm and embryo development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Zong M.I.N., Yu S.I.D.N.E.Y., Chan D., Cheah K.S.E. and Tanner J.A., Different Mutations in Sedlin Cause X-Linked Spondyloepiphyseal Dysplasia Tarda via Two Distinct Mechanisms: Protein Misfolding and Protein-Protein Interaction Abrogation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Choi M.Y., Wang Y., Wong L.L.Y., Lu B., Chen W., Huang J., Tanner J.A. and Watt R.M., The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities, PLoS ONE. 2012, 7(8): e42561.

DIRKZWAGER R.M., CHEUNG Y.W. and Tanner J.A., The use of aptamer-conjugated nanoparticles in novel malaria diagnosis platforms, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

KINGHORN A.B. and Tanner J.A., The genetics of SELEX, Hong Kong Inter-University Biochemistry Postgraduate Symposium 2013.

Kinghorn A.B. and Tanner J.A., Selex in silico, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Tanner J.A., Member of Academic Editorial Board, Current Chemical Biology. 2013.

Tanner J.A., Member of Academic Editorial Board, Frontiers in Bioscience. 2012.

Tanner J.A., Member of Academic Editorial Board, Frontiers in Bioscience. 2013.

Tanner J.A., Member of Academic Editorial Board, JSM Biochemistry & Molecular Biology. 2013.

Tanner J.A., Cheung Y.W. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis, PCT International Application. 2013, PCT/CN2013/071467.

Tanner J.A., Nucleic acids aptamers for malaria diagnosis – discovery, structure and application. , IATI-Biomed 2013, Tel Aviv, Israel. 2013.

Tanner J.A., UC Berkeley Visiting Scholar Award 2012, Centre for Studies in Higher Education, University of California Berkeley. 2012.

Tucker W.O. and Tanner J.A., DNA Aptamers Selected for the Inhibition of E3 Ubiquitin Ligase WWP1, 8th Annual Meeting of the Oligonucleotide Therapeutics Society, Harvard Medical School, Boston, USA . 2012.

Tucker W.O. and Tanner J.A., E3 Ubiquitin ligase WWP1 - An intracellar target for aptameric inhibition, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

YU Y. and Tanner J.A., Nucleic acid aptamers against aggrecanases: a novel method for degenerative disc disease therapy, World Biotechnology Congress 2013, Boston, USA. 2013.

Yu Y. and Tanner J.A., Aggrecanase expression, refolding, puriffication and characterization as a foundation for tailored differential SELEX, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Yu Y. and Tanner J.A., DNA aptamers that inhibit aggrecanase activity for degenerative disc disease and osteoarthritis therapy, 11th CGCM Consortium Meeting, Macau. 2012.

Yu Y., Chan W.L., Shum K.T. and Tanner J.A., Tailored Selection of Nucleic Acid Aptamers against Sclerostin and Aggrecanase for Skeletal Disease Therapeutics, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Tsang KY

Project Title:	The Role of Fibroblast Growth Factor 21 in ER Stress-Induced Skeletal Dysplasia
Investigator(s):	Tsang KY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	2013 Gordon Research Conference on Cartilage Biology and Pathology; Col10a1 deficiency exacerbates pathological calcification and impairs cartilage resorption in MGP-null mice
Investigator(s):	Tsang KY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of hypertrophic chondrocytes , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Niu B., Tan Z., Tsang K.Y., Melhado I.G., Chan D., Zhang M.Q. and Cheah K.S.E., Bioinformatics-aided discovery of Transcriptional Regulators of Chondrocyte Differentiation in the Growth Plate, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Tan Z., Niu B., Tsang K.Y., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Integration of Factors and Pathways facilitating Chondrocyte Adaptation to ER Stress, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Tsang K.Y., Yang L., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Tsang SL

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Zhang H., Wong E.Y.M., Tsang S.L. and Sham M.H., The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated branchio-Oto-Renal syndrome, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12. 2012.

Researcher : Tsang SW

Project Title:	Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo
Investigator(s):	Tsang SW, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Tsang S.W., Yang Y., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes affects trabecular bone formation., Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Tsui MG

List of Research Outputs

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a cadidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a Candidate Gene for Brachydactyly Type A1, encodes a Secreted Protein that Negatively Modulates Hedgehog Signaling, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Tsui YP

List of Research Outputs

Cai S., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of human neural crest stem cells from human induced pluripotent stem cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: therapeutic potential and developmental origin, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy with oligodendrocyte precursor derivation from bone marrow stromal cells, Soc. Neuroscience Abstract (USA), 632.06/A6. 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursor cells from bone marrow stromal cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Researcher : Tsui YP

List of Research Outputs

Researcher : Tucker WO

List of Research Outputs

Tucker W.O. and Tanner J.A., DNA Aptamers Selected for the Inhibition of E3 Ubiquitin Ligase WWP1, 8th Annual Meeting of the Oligonucleotide Therapeutics Society, Harvard Medical School, Boston, USA . 2012.

Tucker W.O. and Tanner J.A., E3 Ubiquitin ligase WWP1 - An intracellar target for aptameric inhibition, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Tung WT

List of Research Outputs

Researcher : WANG B

List of Research Outputs

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Researcher : WANG P

List of Research Outputs

Qin J., Li M.J., Wang P. and Wang J.J., Integrative approach for Omic data analysis and gene regulatory network construction, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., FaSD: a efficient model to detect SNPs for NGS data., 17th Annual International Conference on Research in Computational Molecular Biology, Tsinghua University, Beijing, 7-10 April, 2013.. 2013.

Researcher : WANG W

List of Research Outputs

Wang W., Xu F. and Wang J.J., Assessment of aligner and SNP caller for next generation sequencing and a fast and accurate SNP detection method, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., FaSD: a efficient model to detect SNPs for NGS data., 17th Annual International Conference on Research in Computational Molecular Biology, Tsinghua University, Beijing, 7-10 April, 2013.. 2013.

Researcher : WANG Y

List of Research Outputs

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications. , Mathematics, computer and life sciences interdisciplinary research young scholars forum, University of Chinese Academy of Sciences, Beijing, China, 18 May 2013.

WANG Y., Zhang M.Q. and Wang J.J., Global landscape of histone modifications contributes to cellular identity determination by affecting gene expression dynamics., Mathematics, computer and life sciences interdisciplinary research young scholars forum, University of Chinese Academy of Sciences, Beijing, China, 18 May 2013.. 2013.

WANG Y., Zhang M.Q. and Wang J.J., Global landscape of histone modifications contributes to cellular identity determination by affecting gene expression dynamics, Genome Informatics 2012 conference, Robinson College, Cambridge, UK, 6-9 September 2012.. 2012.

Wang Y., Lu L.H., Wu M.H., Chan D., Cheah K.S.E., Sham M. and Cheung M.C.H., Induction of Osteo-chondroprogenitor Formation by Defined Transcription Factor-mediated Reprogramming Process, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : WANG Z

List of Research Outputs

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Researcher : WONG HLX

List of Research Outputs

WONG H.L.X. and Zhou Z., The Functional Crosstalk between MT1-MMP and ADAMs. , Gordon Research Conference - Matrix Metalloproteinases: Crucial Components of Molecular Networks and Disease Pathways. Lucca, Italy. 2013.

WONG H.L.X. and Zhou Z., The Regulation of FGF Signaling by MT1-MMP in Calvarial Osteogenesis, International Conference on Life Science & Biological Engineering. Tokyo, Japan 2013.

Wong H.L.X., Chan K.M. and Zhou Z., MT1-MMP inactivates ADAM9 to regulate FGF signaling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Researcher : Wang C

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-26, 2012. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D.A.V.I.D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophic Chondrocytes to ER Stress , Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Wang JJ

Project Title:	Evolution and functional specialization of alternative promoters in humans
Investigator(s):	Wang JJ, Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2009
Completion Date:	08/2012

Project Title:	A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
Investigator(s):	Wang JJ, Tsao GSW
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Understanding genetic and epigenetic features of active promoters in human/mouse embryonic stem cells
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	Understanding the co-evolutionary relationship between transcription factors and their DNA binding sites for bHLH family in eukaryotes
Investigator(s):	Wang JJ, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	A computational framework to detect SNPs from next-generation sequencing data
Investigator(s):	Wang JJ, Sham PC
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2013

Project Title:	BIT's 2nd Annual World Congress of Molecular & Cell Biology Integrative analysis of high throughput genomic data for network construction
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	Outstanding Young Researcher Award 2011-12
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2013

Project Title:	A computational framework to infer regulatory modules from integrative analysis of ChIP-seq and transcriptome data
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Design of versatile super promoters for highly efficient mammalian gene expression
Investigator(s):	Wang JJ, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

List of Research Outputs

LI J., WANG Y., Xia Z., Sham P.C. and Wang J.J., GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications. , Mathematics, computer and life sciences interdisciplinary research young scholars forum, University of Chinese Academy of Sciences, Beijing, China, 18 May 2013.

LI J., Sham P.C. and Wang J.J., Genetic variants representation, annotation and prioritization in the post-GWAS era, Cell Research. 2012, 22: 1505–1508.

Li J. and Wang J.J., Discovery of functional genetic variants in the post-GWAS era, IEEE International Conference on Systems Biology, Xi’an, China, Aug 18-20. 2012.

Qin J., Li M.J., Wang P. and Wang J.J., Integrative approach for Omic data analysis and gene regulatory network construction, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

WANG Y., Zhang M.Q. and Wang J.J., Global landscape of histone modifications contributes to cellular identity determination by affecting gene expression dynamics., Mathematics, computer and life sciences interdisciplinary research young scholars forum, University of Chinese Academy of Sciences, Beijing, China, 18 May 2013.. 2013.

WANG Y., Zhang M.Q. and Wang J.J., Global landscape of histone modifications contributes to cellular identity determination by affecting gene expression dynamics, Genome Informatics 2012 conference, Robinson College, Cambridge, UK, 6-9 September 2012.. 2012.

Wang J.J., A fast and accurate SNP detection algorithm for NGS data , IEEE International Conference on Systems Biology, Xi’an, China, Aug 18-20. 2012.

Wang J.J., A fast and accurate SNP detection algorithm for NGS data, ISCB-Asia, Shenzhen, China, 17-19 December 2012. 2012.

Wang J.J., Bioinformatics tools for next generation sequencing data analysis and gene regulatory network inference, HUST-HKU Genetics & Bioinformatics Symposium, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, China, 4 June 2013. 2013.

Wang J.J., Bioinformatics tools for next generation sequencing data analysis and gene regulatory network inference, Key Laboratory of Medical Molecular Virology, Fudan University Shanghai Medical School, Shanghai, China, 23 April 2013. 2013.

Wang J.J., Bioinformatics tools for next generation sequencing data analysis, Department of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China, 22 April 2013. 2013.

Wang J.J., Co-chair for Regulatory Networks in Stem Cells Session, in RMSC-2012, Guangzhou, China, Dec. 2-4, 2012.

Wang J.J., Constructing epigenetic regulatory networks from high throughput gene expression and ChIP-seq data, 5th annual world congress of regenerative medicine & stem cell-2012, Guangzhou, China, 1-4 December 2012.. 2012.

Wang J.J., Detection, Reprioritizing and Functional Annotation of Genetic Variations for Next Generation Sequencing data, State Key Lab of Systems Biology, CAS, Shanghai, China, 19 April 2013.. 2013.

Wang J.J., Editorial Board Member, 2012- present., ISRN Genetics. 2012.

Wang J.J., Editorial Board Member, 2012-present, Enzyme Engineering. 2012.

Wang J.J., From genomics to proteomics: Integrative analysis of OMICs data for functional genomics, School of Biological Science, The University Of Hong Kong, Hong Kong, China, 7 September 2012.. 2012.

Wang J.J., From genomics to proteomics: Integrative analysis of OMICs data for functional genomics, School of Computer, Wuhan University, Wuhan, China, 23 Aug.. 2012.

Wang J.J., Genetic Variations in the Next Generation: Detection, Reprioritizing and Functional Annotation, Frontier in Biomedical Research 2012, Faculty of Medicine, The University of Hong Kong, Hong Kong, China, 14 December 2012.. 2012.

Wang J.J., Integrative analysis of genomic data for gene function inference, Institute for Nutritional Sciences, SIBS, Shanghai, China, 15 November 2012.. 2012.

Wang J.J., Outstanding Young Researcher Award (2011-2012), The University of Hong Kong. 2013.

Wang J.J., PC member, BIBM 2012- IEEE International Conference on Bioinformatics & Biomedicine 2012, 4-7 Oct., 2012, Philadelphia, PA, USA. 2012.

Wang J.J., PC member, ISB 2012-IEEE International Conference on Systems Biology, 18-20 August, 2012, Xi’an, China. 2012.

Wang J.J., Systems biology approaches for integrative analysis of next generation sequencing data, School of Food Science & Technology, Huazhong Agricultural University, Wuhan, China, 5 June, 2013. 2013.

Wang W., Xu F. and Wang J.J., Assessment of aligner and SNP caller for next generation sequencing and a fast and accurate SNP detection method, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., FaSD: a efficient model to detect SNPs for NGS data., 17th Annual International Conference on Research in Computational Molecular Biology, Tsinghua University, Beijing, 7-10 April, 2013.. 2013.

YALAMANCHILI H.K., Xiao Q.W. and Wang J.J., A Neural Response Algorithm for Protein Function Prediction, BMC Systems Biology. 2012, 6(S1): S19.

YALAMANCHILI H.K., Xiao Q.W. and Wang J.J., A Novel Neural Response Algorithm for Protein Function Prediction., The IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2012), Philadelphia, USA, 4-7 October 2012.. 2012.

Yalamanchili H.K. and Wang J.J., Gene regulatory network inference from high frequency time series data, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Wang P

List of Research Outputs

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

Researcher : Wang W

List of Research Outputs

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

Researcher : Wang X

List of Research Outputs

HOR H.H., Wang X., Hui C.C. and Sham M.H., Best Post Award: Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4 , Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanism, November 26-27, 2012. 2012.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu controls the number and cell fate of hindbrain progenitors, 46th Annual Meeting for the Japanese Society of Developmental Biologists, Matsue, Japan, May 28 – 31. 2013.

HOR H.H., Wang X., Hui C.C. and Sham M.H., Sufu defines the balance of hindbrain progenitor cells maintenance and differentiation, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) functions upstream of notch pathway and plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused Controls The Maintenance of Neural Progenitor Pools and Regulates Notch Pathway Activity in Rhombomere 4, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Wang X

List of Research Outputs

Researcher : Wang Y

List of Research Outputs

Researcher : Wang Z

List of Research Outputs

Researcher : Wong EYM

List of Research Outputs

Zhang H., Wong E.Y.M., Tsang S.L. and Sham M.H., The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated branchio-Oto-Renal syndrome, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12. 2012.

Researcher : Wong HLX

List of Research Outputs

WONG H.L.X. and Zhou Z., The Regulation of FGF Signaling by MT1-MMP in Calvarial Osteogenesis, International Conference on Life Science & Biological Engineering. Tokyo, Japan 2013.

Wong H.L.X., Chan K.M. and Zhou Z., MT1-MMP inactivates ADAM9 to regulate FGF signaling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Researcher : Wong MK

List of Research Outputs

Wong M.K., Lui Y.Y., Chan Y.S. and Shum D.K.Y., Chondroitin sulfate moieties control motor neuron migration in the rat embryonic hindbrain, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 67. 2013.

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	Investigation of threshold mechanisms in cellular responses to stress
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	ASBMB Annual Meeting 2013; The potential role of Simian Virus 40 polyA sequence (SV40 polyA) to mediate stress-inducible mRNA translation
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	Hydrogen peroxide signaling - the role of thioredoxin reductase
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Wong N.S., Academic Editor, PlosONE. 2013.

Wong N.S. and LUI W.T., The Potential Role Of Simian Virus 40 PolyA Sequence To Mediate Stress-inducible mRNA Translation, Experimental Biology 2013.

Researcher : Wong YME

List of Research Outputs

Chu K.H., Zhang M., Wong Y.M.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion. , Current Trends in Biomedicine: Molecular Mechanisms of Inner Ear Development, Jaen, Spain, November 5, . 2012.

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Researcher : Wu LK

List of Research Outputs

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase activity enhances MMP-7 dependent syndecan-1 shedding in the airway, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Wu MH

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K.K. and Cheung M.C.H., Investigating the Role of SOX9 in Human Neural Stem Cells, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of SOX9 in human neural stem cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

LIU A., Wu M.H., Yan H.C., Chau K.H.B., So H., Ng A., Chan A., Cheah K.S.E., Briscoe J. and Cheung M.C.H., Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling, In: Marianne E. Bronner, Proceeding of the National Academy of Sciences of the United States of America. United States, 2013, 110: 2882-2887.

Liu A., Wu M.H., Yan C.A.R.O.L., Chau B.O.L.T.O.N., So H.E.N.R.Y., Ng A.L.V.I.S., Chan A.L.A.N., Cheah K.S.E., Briscoe J.A.M.E.S. and Cheung M.C.H., Post-translational Regulation of Sox9 in Neural Crest Delamination, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Wang Y., Lu L.H., Wu M.H., Chan D., Cheah K.S.E., Sham M. and Cheung M.C.H., Induction of Osteo-chondroprogenitor Formation by Defined Transcription Factor-mediated Reprogramming Process, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-rangeSOX9Enhancers in Limb Development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Wu X

List of Research Outputs

Osorio Da Silva L.A., Wu X. and Zhou Z., Understanding the Biological Role of Isthmin during Mouse Development and Homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : XU F

List of Research Outputs

Wang W., Xu F. and Wang J.J., Assessment of aligner and SNP caller for next generation sequencing and a fast and accurate SNP detection method, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., FaSD: a efficient model to detect SNPs for NGS data., 17th Annual International Conference on Research in Computational Molecular Biology, Tsinghua University, Beijing, 7-10 April, 2013.. 2013.

Researcher : XUE W

List of Research Outputs

WANG Z., XUE W., LIN R., Li X., Cui J. and Huang J., N-terminus of desmin controls its retrograde transportation in differentiating myoblast cells, Jouranal of China-Japan Friendship Hospital. 2012, V27(3): P164-167.

Wang Z., XUE W., Li X., Lin R., Cui J. and Huang J., Dissect Kif5b in nuclear positioning during myogenesis: The light chain binding domain and the autoinhibitory peptide are both indispensable, Biochemical and Biophysical Research Communications. 2013, 432: 242-247.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

Xue W., Kinesin-1 Affects Chondrocytes Adhesion to Extracellular Matrix and Motility, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Xue W., Gan H., Zhu Y. and Huang J., Kinesin-1 affects chondrocytes adhesion to extracellular matrix and motility, KIF5B contributes to cell polarization during epithelial morphogenesis. 2012.

Researcher : Xie S

List of Research Outputs

Xie S., Jean J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Xu F

List of Research Outputs

XU F., WANG W., WANG P., LI J., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Nature Communications. 2012, 3: 1258.

Researcher : Xue W

List of Research Outputs

Xue W., Gan H., Zhu Y. and Huang J., Kinesin-1 affects chondrocytes adhesion to extracellular matrix and motility, KIF5B contributes to cell polarization during epithelial morphogenesis. 2012.

Researcher : YALAMANCHILI HK

List of Research Outputs

YALAMANCHILI H.K., Xiao Q.W. and Wang J.J., A Neural Response Algorithm for Protein Function Prediction, BMC Systems Biology. 2012, 6(S1): S19.

YALAMANCHILI H.K., Xiao Q.W. and Wang J.J., A Novel Neural Response Algorithm for Protein Function Prediction., The IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2012), Philadelphia, USA, 4-7 October 2012.. 2012.

Yalamanchili H.K. and Wang J.J., Gene regulatory network inference from high frequency time series data, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : YIP KHR

List of Research Outputs

Liu B., YIP K.H.R. and Zhou Z., Chromatin Remodeling, DNA Damage Repair and Aging, Current Genomics. 2012, 13: 533-547.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-rangeSOX9Enhancers in Limb Development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : YU B

List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.

Researcher : YU Y

List of Research Outputs

YU Y. and Tanner J.A., Nucleic acid aptamers against aggrecanases: a novel method for degenerative disc disease therapy, World Biotechnology Congress 2013, Boston, USA. 2013.

Yu Y. and Tanner J.A., Aggrecanase expression, refolding, puriffication and characterization as a foundation for tailored differential SELEX, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Yu Y. and Tanner J.A., DNA aptamers that inhibit aggrecanase activity for degenerative disc disease and osteoarthritis therapy, 11th CGCM Consortium Meeting, Macau. 2012.

Yu Y., Chan W.L., Shum K.T. and Tanner J.A., Tailored Selection of Nucleic Acid Aptamers against Sclerostin and Aggrecanase for Skeletal Disease Therapeutics, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : YUEN KS

List of Research Outputs

YUEN K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores cellular proapoptotic protein PUMA expression by silencing Epstein-Barr virus-encoded miR-BART5 in nasopharyngeal carcinoma cells , International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, Pennsylvania, USA, August 1-4, 2012.. 2012.

Researcher : Yalamanchili HK

List of Research Outputs

YALAMANCHILI H.K., Xiao Q.W. and Wang J.J., A Neural Response Algorithm for Protein Function Prediction, BMC Systems Biology. 2012, 6(S1): S19.

Researcher : Yang L

List of Research Outputs

Tsang K.Y., Yang L., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Secreted PDZ domain-containing protein 2 and regulation of Sonic hedgehog signaling during neural tube development
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

List of Research Outputs

Chong T.Y.I., Lee C.Y.L., Shiu S.Y.W. and Yao K.M., Using small molecules to induce the progressive differentiation of hESCs into pancreatic β-cell-like progenitors, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012.

Lam K.Y., Ngan W.L., Leung M.H., Kwok C.T.D., Liu V.W.S., Chan D.W., Leung W.Y.G. and Yao K.M., FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c, Frontiers in Oncology. Frontiers, 2013, 3: 1-5.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a cadidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui M.G., Chan D., Cheah K.S.E., Cheung M.C.H. and Yao K.M., PDZD2, a Candidate Gene for Brachydactyly Type A1, encodes a Secreted Protein that Negatively Modulates Hedgehog Signaling, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

WONG S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Biocompatible cell-entrapping intraocular implant, Eighth International Symposium on Healthy Aging: “How to Age with Finesse”. 2013.

Researcher : Yee FYA

List of Research Outputs

Song Y., Karasugi T., Cheung K.M.C., Chiba K., Ho D.W.H., Miyake A., Kao P.Y.P., Sze K.L., Yee F.Y.A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togawa D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W.E.I., Wang N.A., Leong J.C.Y., Luk K.D.K., Yip S.P., Cherny S.S., Wang J.J., Mundlos S., Kelempisioti A., Eskola P. .J., Mannikko M., Makela P., Karppinen J., Jarvelin M. .R., O Reilly P. .F., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah K.S.E., Tsunoda T., Sham P.C., Ikegawa S. and Chan D., Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Yee F.Y.A., Lam P.Y., Dong H.G., Lam Y.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Changes in the Proteome of the Human Intervertebral Disc in Aging and Degeneration, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Yip KHR

List of Research Outputs

Liu B., YIP K.H.R. and Zhou Z., Chromatin Remodeling, DNA Damage Repair and Aging, Current Genomics. 2012, 13: 533-547.

Researcher : Yip MS

Project Title:	Role of type II collagen cleavage and immune responses in intervertebral disc degeneration in vivo
Investigator(s):	Yip MS, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	05/2013

Researcher : Yu Y

List of Research Outputs

YU Y. and Tanner J.A., Nucleic acid aptamers against aggrecanases: a novel method for degenerative disc disease therapy, World Biotechnology Congress 2013, Boston, USA. 2013.

Yu Y. and Tanner J.A., DNA aptamers that inhibit aggrecanase activity for degenerative disc disease and osteoarthritis therapy, 11th CGCM Consortium Meeting, Macau. 2012.

Researcher : ZHANG H

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Analysis of craniofacial defects in Six1/Eya1-associated Branchio-Oto-Renal Syndrome, 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

Zhang H., Wong E.Y.M., Tsang S.L. and Sham M.H., The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated branchio-Oto-Renal syndrome, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12. 2012.

Researcher : ZHANG Y

List of Research Outputs

Jia Y., Chau W.H., Zhang Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

Zhang Y., Chan W.C.W., Sakai D. and Chan D., The influence of progenitor cells in intervertebral disc degeneration and regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : ZHENG S

List of Research Outputs

ZHENG S., YU B., ZHANG K., Chen M., HUA Y., YUAN S., Watt R.M., Zheng B., Yuen K.Y. and Huang J., Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology. 2012, 13:54.

Researcher : ZHOU S

List of Research Outputs

Liu B., ZHOU S., Liu X., Zhou K., Zhang F. and Zhou Z., Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model., BMC Longevity & Healthspan. 2013.

Researcher : Zhang H

List of Research Outputs

Researcher : Zhang L

List of Research Outputs

Chan W.C.W., Zhang L., Cheah K.S.E. and Chan D., Chondrocytes from the Endplate Cartilage Contribute to the Inner Annulus Fibrosus in normal and degenerative intervertebral Disc, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Liu B., Zhang L., Ghosh S. and Zhou Z., Depleting Suv39h1 methyltransferase rescues defective DNA repair and extends lifespan in progeria mouse model., Keystone Symposia Aging and Diseases of Aging (S2) 2012, Tokyo, Japan.. 2012.

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Researcher : Zhang L

List of Research Outputs

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Researcher : Zhang M

List of Research Outputs

Chu K.H., Zhang M., Wong Y.M.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion. , Current Trends in Biomedicine: Molecular Mechanisms of Inner Ear Development, Jaen, Spain, November 5, . 2012.

Leung C., Zhang M., SIT H.M. and Sham M.H., Sox10 regulates enteric neural crest cell migration in the developing gut., 17th International Congress of Developmental Biology, Cancun, Mexico, June 16-20. 2013.

SIT H.M., Zhang M., Leung C. and Sham M.H., The role of Sox10 in enteric neural crest cellmigration, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Sit H.M., Zhang M., Leung C. and Sham M.H., The role of SOX10 in enteric neural crest cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.

Researcher : Zhang Y

List of Research Outputs

Researcher : Zhang Y

List of Research Outputs

Researcher : Zheng H

List of Research Outputs

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.

Researcher : Zhou J

List of Research Outputs

Zhou J. and Zhou Z., Loss of MT1-MMP affects CNS development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Ageing and longevity: biology and challenge
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	02/2009

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Isthmin In Fibroblast Growth Factor Signaling and Nodal Signaling during Embryogenesis and Development
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2011

Project Title:	MT1-MMP regulates neural stem cell self-renewal and differentiation
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	MT1-MMP-mediated ADAM15 shedding in angiogenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Novel SIRT1 activator
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

List of Research Outputs

Ghosh S., Liu B. and Zhou Z., Resveratrol activates SIRT1 in a Lamin A-dependent manner, Cell Cycle. 2013, 12(6): 872-6.

HU X. and Zhou Z., UHRF1 regulated hair follicle stem cells self-renewal, Gordon Research Conference on Epithelial Differentiation & Keratinization: New Frontiers and Therapeutics, Lucca, Italy. 2013.

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.

Liu B., ZHOU S., Liu X., Zhou K., Zhang F. and Zhou Z., Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model., BMC Longevity & Healthspan. 2013.

Liu B. and Zhou Z., Activation of SIRT1 by resveratrol requires lamin A, Aging (Albany NY). 2013, 5(2): 94-5.

Liu B., YIP K.H.R. and Zhou Z., Chromatin Remodeling, DNA Damage Repair and Aging, Current Genomics. 2012, 13: 533-547.

Liu B., Wang Z., Ghosh S. and Zhou Z., Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model, Aging Cell. 2013, 12(2): 316-8.

Liu B., Zhang L., Ghosh S. and Zhou Z., Depleting Suv39h1 methyltransferase rescues defective DNA repair and extends lifespan in progeria mouse model., Keystone Symposia Aging and Diseases of Aging (S2) 2012, Tokyo, Japan.. 2012.

Liu B., Wang Z., Zhang L., Ghosh S., Zheng H. and Zhou Z., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model, Nat Commun. 2013, 4: 1868.

Liu B., Ghosh S., Zheng H., Liu X., Wang Z., Jin G., Zheng B., Kennedy B.K., Suh Y., Kaeberlein M., Tryggvason K. and Zhou Z., Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria, Cell Metab. 2012, 16(6): 738-50.

Liu B. and Zhou Z., Resveratrol rescues Sirt1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria., EMBL Conference: Stem Cells in Cancer and Regenerative Medicine 2012, Heidelberg, Germany.. 2012.

Liu B. and Zhou Z., SIRT1, end of the story in aging., International Symposium of AAAR 2012, Fukuoka, Japan.. 2012.

Osorio Da Silva L.A., Wu X. and Zhou Z., Understanding the Biological Role of Isthmin during Mouse Development and Homeostasis, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Osorio Da Silva L.A. and Zhou Z., Understanding the biological role of isthmin in mouse development and homeostasis, HKSDB – From Embryology to Disease Mechanism – In honour of Patrick Tam – 60 years & Still Gastrulating, Hong Kong. 2012.

WONG H.L.X. and Zhou Z., The Functional Crosstalk between MT1-MMP and ADAMs. , Gordon Research Conference - Matrix Metalloproteinases: Crucial Components of Molecular Networks and Disease Pathways. Lucca, Italy. 2013.

WONG H.L.X. and Zhou Z., The Regulation of FGF Signaling by MT1-MMP in Calvarial Osteogenesis, International Conference on Life Science & Biological Engineering. Tokyo, Japan 2013.

Wong H.L.X., Chan K.M. and Zhou Z., MT1-MMP inactivates ADAM9 to regulate FGF signaling, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2012.

Wong H.L.X., Cao R., Jin G., Chan J.K.M., Cao Y. and Zhou Z., When MT1-MMP Meets ADAMs, Cell Cycle . Landes Bioscience, 2012, 11(15): 2793-2798.

Zhou J. and Zhou Z., Loss of MT1-MMP affects CNS development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27, 2012 . 2012.

Zhou Z., Alterations in Histone modifications in aging and accelerated aging, Presidential Symposium of 20th IAGG World Congress of Gerontology and Geriatrics. Seoul, Korea, 2013.

Zhou Z., Biochemistry and Analytical Biochemistry. 2012.

Zhou Z., Chromatin remodelling regulated by nuclear lamins in DNA repair and accelerated aging., Annual Meeting Chinese Society of Cell Biology. Wuhan, China, 2013.

Zhou Z., Epigenetic regulations of Aging, Asian Association of Aging Research Symposium. Furuwaka, JAPAN, 2012.

Zhou Z., Epigenetics，Stem Cells and Aging , IV National Symposium on Cell Structure and Function Chinese Society of Cell Biology. 2012.

Zhou Z., Extracellular Matrix and Membrane-type Matrix metalloproteinase in Development and Diseases, 2012 Asia-Pacific Developmental Biology Conference. Taiwan, 2012.

Zhou Z., MT1-MMP in regulating growth factor signalling and development. , 1st National Congress on Developmental Biology. Xi'an, 2012.

Zhou Z., MT1-MMP inactivates ADAM9 to regulate osteogenesis, International Conference on Tooth/Bone Development and Regeneration 2012. Chengdu, China, 2012.

Zhou Z., Resveratrol as a potential treatment of HGPS, The Progeria Research Foundation Scientific Workshop . Bethesda, USA, 2013.

Zhou Z., member of editorial board, Clinical & Experimental Pharmacology & Physiology . Malden MA 02148, USA, John Wiley & Sons Inc, 2013.

Researcher : Zhu G

List of Research Outputs

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of Kinesin-1 mediated intracellular transport in skeletal development, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Researcher : Zhu Y

List of Research Outputs

Xue W., Gan H., Zhu Y. and Huang J., Kinesin-1 affects chondrocytes adhesion to extracellular matrix and motility, KIF5B contributes to cell polarization during epithelial morphogenesis. 2012.

-- End of Listing --