DEPT OF MEDICINE



Researcher : Au WY

List of Research Outputs

Love C.L., Jima D., Sun Z., Miles R.R., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K., Evens A.M., Chadburn A., Gordon L.I., Czader M., Gill J., Hsi E.D., Zhang J., Grubor V., Levy S., Bunerjee A., Dunson D., Li G., Moffitt A., Greenough A., McKinney M.S. and Dave S.S., ID3 is a novel tumor suppressor gene in Burkitt lymphoma, The 54th American Society of Hematology Annual Meeting and Exposition. 2012.
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D. and Dave S.S., Genetic heterogeneity of diffuse large B-cell lymphoma, Proc Natl Acad Sci U S A. 2013, 110(4): 1398-403.


Researcher : Bow CHY

List of Research Outputs

Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Bow HYC

List of Research Outputs

Cheung E., Bow H.Y.C., Loong C., Lee K.K., Ho A.Y.Y., Soong S.S., Chan Y.Y. and Kung A.W.C., A secular increase in BMD in Chinese women., Journal of Bone and Mineral Metabolism. 2013.


Researcher : Bu L

Project Title:Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):Bu L, Li RA
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Human WT1 epicardial progenitor cells
Investigator(s):Bu L, Li RA
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Study of cardiomyopathy through genome editing in human pluripotent stem cells
Investigator(s):Bu L, Li RA
Department:Physiology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Li R.A., Bu L. and Lui O.L.K., Human pluripotent stem cell-derived cardiovascular progenitors for heartregeneration, Drug Discovery Today: Disease Model. In press.. 2012.


Researcher : But YKD

List of Research Outputs

Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.


Researcher : CHAN HT

List of Research Outputs

Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.


Researcher : CHAN KH

List of Research Outputs

Chan K.H., Member of Organizing Committee , 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. Hong Kong, 2012.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chan K.H., Associate Editor, Open Journal of Immunology . 2012.
Chan K.H., Clinical Features, Diagnosis and Immunopathogenesis of Neuromyelitis Optica Spectrum Disorders , 2012.
Chan K.H., Co-Chairman of Organizing Committee of “Natalizumab in Clinical Practice and Certificate course”, co-organized by the Hong Kong Neurological Society and Hong Kong Multiple Sclerosis Society. Hong Kong, 2013.
Chan K.H., Expert consensus statements on the use of IVIG IN NEUROLOGY. , The Asia-Pacific IVIG Advisory Board. 3rd Edition. 2013.
Chan K.H., GRF Incentive Award, Univeristy Research Committee. 2012.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Chan K.H., Invited Chairmanship of Symposium XI: Aging Eyes of the 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Invited Speaker &Discussant, , The Guthy-Jackson Charitable Foundation’s fifth NMO Roundtable Conference. Los Angelos, USA, 2012.
Chan K.H., Management of multiple sclerosis and neuromyelitis optica for the non-neurologists, 18th Hong Kong Medical Forum. 2013.
Chan K.H., Member of Organizing Committee of the 8th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Myasthenia Gravis and Pregnancy, Commissioned Training in Obstetrics and Gynaecology 2012/2013. 2013.
Chan K.H., Neuromyelitis Optica in Hong Kong Chinese, 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. 2012.
Chan K.H., Novel immunomodulation for neuroinflammation, Research Meeting, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2013.
Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Pregnancy in Myasthenia Gravis, Hospital Authority Commissioned Training. Hong Kong, 2013.
Chan K.H., Treatment of Central Nervous System Inflammatory Demyelinating Disorders, 24th Annual Scientific Meeting of the Hong Kong Neurological Society. 2012.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
QIAN W., Chan K.H., Chan Q. and Mak H.K.F., Assessment of normal-appearing brain tissue changes in multiple sclerosis using diffusion kurtosis imaging. , International Society of Magnetic Resonance in Medicine 22nd Annual Scientific Meeting and Exhibition, 2013. . 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Chan AOO

List of Research Outputs

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.


Researcher : Chan CYJ

List of Research Outputs

Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chiu M.L.S., Hu M., Ng M.H.L., Yeung C.K., Chan C.Y.J., Chang M.M., Cheng S.H., Li L. and Tomlinson B., Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong, British Journal of Dermatology. 2012, 167(1): 44-49.
Shea Y.F., Chan C.Y.J., Hung I.F.N. and Chan K.H., Hand, Foot and Mouth Disease in an Immunocompetent Adult due to Coxsackievirus A6, Hong Kong Medical Journal. 2013, 19(3): 262-4.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.


Researcher : Chan DTM

Project Title:The role of annexin II in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Characterization of renal proximal tubular epithelial cell antigens that mediate anti-dsDNA antibody binding and internalization, and their pathogenic role in lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:The role of fibronectin in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:02/2013


Project Title:The role of hyaluronan and effect of 4-methylumbelliferone in tubulo-interstitial fibrosis in lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:American Society of Nephrology Kidney Week 2012; Anti-annexin II Level in Serum Correlates with Disease Manifestations in Lupus Nephritis
Investigator(s):Chan DTM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:The Role of Annexin II in the Regulation of Inflammation and Fibrosis in Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of connective tissue growth factor in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2013


List of Research Outputs

Chan D.T.M., Cheung K.F., Yim A.S.Y., Yap Y.H.D. and Yung S.S.Y., Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis, Journal of the American Society of Nephrology. 2012, 23: 567A.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin Suppresses Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of PKC-alpha Phosphorylation, Peritoneal Dialysis International . 2012, 32: S120.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin suppresses fibrotic processes in human peritoneal mesothelial cells through inhibition of PKC-alpha phosphorylation, 14th Congress of the International Society for Peritoneal Dialysis, Kuala Lumpur, Malaysia. 2012.
Cheung W.T., Yung S.S.Y., Chan D.T.M., Leung P.C.K. and Wong A.S.T., Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion, Molecular Therapy. 2013, 21: 78-90.
Choy B.Y., Lam M.F., Yip T., Tang H.L., Wong P.N., Chow C.C., Yap Y.H.D. and Chan D.T.M., Dosing Regimen and Tolerability of Methoxy Polyethylene Glycol-Epoetin Beta in Chinese Dialysis Patients, Nephrology (Carlton). 2013.
HO S.K., Yung S.S.Y., Cheung K.F., Tse W.W. and Chan D.T.M., Anti-dsDNA antibodies induce epithelial-to-mesenchymal transition and fibrotic processes in human proximal renal tubular epithelial cells, ASN Kidney Week 2012. 338A.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin inhibits epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells through inhibition of MAPK phosphorylation, ISN World Congress of Nephrology 2013.
Kwan L.P., Choy C.B.Y., Chan D.T.M., Suen W.S. and Yap Y.H.D., Successful treatment of pulmonary rhizopus infection with surgical resection and posaconazole in a renal transplant recipient, Nephrology (Carlton). 2013, 18(1): 74-5.
Li P.H., Wong W.H.S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Tong K.L., Tse N.K.C., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chong C.Y., Wong R.W.S., Mok T.M.Y., Ying S.K.Y., Fung S.K.S., Lai W.M., Yang W. and Lau Y.L., Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese, Rheumatology. Oxford, 2013, 52(2): 337-345.
Lui S.L., Yung S.S.Y., Yim A.S.Y., Wong K.M., Tong K.L., Wong K.S., Li C.S., Au T.C., Lo W.K., Ho Y.W., Ng F., Tang S.O.C. and Chan D.T.M., A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport, and Inflammation Markers: A Randomized Clinical Trial, American Journal of Kidney Diseases. 2012, In press.
TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.
Yap Y.H.D., Kwan L.P., To K.K.W. and Chan D.T.M., Arcobacter peritonitis after fluoroscopic repositioning of a Tenckhoff catheter, Peritoneal Dialysis International. 2013, 33(2): 222-3.
Yap Y.H.D., Chan G.C.W., Mok M.M. and Chan D.T.M., Epistaxis in a kidney transplant recipient - an uncommon presentation of post-transplant lymphoproliferative disease [Epub ahead of print], Nephrology (Carlton). 2013.
Yap Y.H.D., Ma K.M.M., Mok M.M., Tang S.O.C. and Chan D.T.M., Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis, Rheumatology (Oxford). 2013, 52(3): 480-6.
Yap Y.H.D., Ma M.K.M. and Chan D.T.M., Outcome of Long-Term Treatment with Mycophenolate Mofetil in Patients with Severe Lupus Nephritis, American Society of Nephrology Kidney Week 2012.
Yap Y.H.D., Ma M.K., Tang C.S. and Chan D.T.M., Proliferation Signal Inhibitors (PSI) in the Treatment of Lupus Nephritis - Preliminary Experience., Nephrology (Carlton). 2012.
Yap Y.H.D., Tang C.S., Ma M.K., Lam M.F. and Chan D.T.M., Survival Analysis and causes of mortality in patients with lupus nephritis, Nephrol. Dial. Transplant.. 2012, 27: 3248-54.
Yap Y.H.D., Ma M.K.M., Mok M.M.Y., Kwan L.P.Y., Chan G.C.W. and Chan D.T.M., The impact of corticosteroids and mycophenolate mofetil treatment on the serum immunoglobulin levels in lupus nephritis patients, World Congress of Nephrology 2013.
Yung S.S.Y., HO S.K., Cheung K.F. and Chan D.T.M., Anti-dsDNA antibodies induce cell activation and fibronectin synthesis in human renal proximal tubular epithelial cells., ISN World Congress of Nephrology 2013.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.
Yung S.S.Y. and Chan D.T.M., Fibronectin in Renal Diseases and Peritoneal Dialysis, In: Beattie, James, Fibronectin: Current Concepts in Structure, Function and Pathology. New York, Nova Science Publishers, 2012, 227-264.
Yung S.S.Y., Chau K.M., Zhang Q., Zhang C. and Chan D.T.M., Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy, PLoS One. 2013, e54501.
Yung S.S.Y. and Chan D.T.M., The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis, Autoimmune Diseases. 2012.
Zhang J., Zhang Y., Zhang L., Yang J., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Lau Y.L. and Yang W., Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients, Annals of Human Genetics. 2013, 77(4): 344-350.
Zhao M., Liu Q., Liang G., Wang L., Luo S., Tang Q., Zhao H., Su Y., Yung S.S.Y., Chan D.T.M. and Lu Q., E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients, J Autoimmun. 2013, 41: 152-160.


Researcher : Chan FHW

List of Research Outputs

Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chu L.W. and Chan F.H.W., Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study, Journal of the American Medical Directors Association. 2012, 13(9): 782-7.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chan F.H.W. and Chu L.W., Prevalence of anemia in Chinese nursing home older adults: Implication of age and renal impairment [Epub ahead of print], Geriatrics & Gerontology International. 2012.


Researcher : Chan GCW

List of Research Outputs

Yap Y.H.D., Chan G.C.W., Mok M.M. and Chan D.T.M., Epistaxis in a kidney transplant recipient - an uncommon presentation of post-transplant lymphoproliferative disease [Epub ahead of print], Nephrology (Carlton). 2013.


Researcher : Chan HHL

Project Title:The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):Chan HHL, Lam LK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2000


Project Title:The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):Chan HHL, Wei WI
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:11/2001




Researcher : Chan JCK

Project Title:Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):Chan JCK, Lam WK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:07/1995




Researcher : Chan K

List of Research Outputs

Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Chan KH

List of Research Outputs

Chan K.H., Member of Organizing Committee , 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. Hong Kong, 2012.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chan K.H., Associate Editor, Open Journal of Immunology . 2012.
Chan K.H., Clinical Features, Diagnosis and Immunopathogenesis of Neuromyelitis Optica Spectrum Disorders , 2012.
Chan K.H., Co-Chairman of Organizing Committee of “Natalizumab in Clinical Practice and Certificate course”, co-organized by the Hong Kong Neurological Society and Hong Kong Multiple Sclerosis Society. Hong Kong, 2013.
Chan K.H., Expert consensus statements on the use of IVIG IN NEUROLOGY. , The Asia-Pacific IVIG Advisory Board. 3rd Edition. 2013.
Chan K.H., GRF Incentive Award, Univeristy Research Committee. 2012.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Chan K.H., Invited Chairmanship of Symposium XI: Aging Eyes of the 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Invited Speaker &Discussant, , The Guthy-Jackson Charitable Foundation’s fifth NMO Roundtable Conference. Los Angelos, USA, 2012.
Chan K.H., Management of multiple sclerosis and neuromyelitis optica for the non-neurologists, 18th Hong Kong Medical Forum. 2013.
Chan K.H., Member of Organizing Committee of the 8th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Myasthenia Gravis and Pregnancy, Commissioned Training in Obstetrics and Gynaecology 2012/2013. 2013.
Chan K.H., Neuromyelitis Optica in Hong Kong Chinese, 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. 2012.
Chan K.H., Novel immunomodulation for neuroinflammation, Research Meeting, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2013.
Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Pregnancy in Myasthenia Gravis, Hospital Authority Commissioned Training. Hong Kong, 2013.
Chan K.H., Treatment of Central Nervous System Inflammatory Demyelinating Disorders, 24th Annual Scientific Meeting of the Hong Kong Neurological Society. 2012.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
QIAN W., Chan K.H., Chan Q. and Mak H.K.F., Assessment of normal-appearing brain tissue changes in multiple sclerosis using diffusion kurtosis imaging. , International Society of Magnetic Resonance in Medicine 22nd Annual Scientific Meeting and Exhibition, 2013. . 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Chan KH

Project Title:Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:01/2008


Project Title:Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):Chan KH, Ho SL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:03/2008


Project Title:The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:04/2009


Project Title:Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010


Project Title:Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2011


List of Research Outputs

Chan K.H., Member of Organizing Committee , 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. Hong Kong, 2012.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chan K.H., Associate Editor, Open Journal of Immunology . 2012.
Chan K.H., Clinical Features, Diagnosis and Immunopathogenesis of Neuromyelitis Optica Spectrum Disorders , 2012.
Chan K.H., Co-Chairman of Organizing Committee of “Natalizumab in Clinical Practice and Certificate course”, co-organized by the Hong Kong Neurological Society and Hong Kong Multiple Sclerosis Society. Hong Kong, 2013.
Chan K.H., Expert consensus statements on the use of IVIG IN NEUROLOGY. , The Asia-Pacific IVIG Advisory Board. 3rd Edition. 2013.
Chan K.H., GRF Incentive Award, Univeristy Research Committee. 2012.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Chan K.H., Invited Chairmanship of Symposium XI: Aging Eyes of the 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Invited Speaker &Discussant, , The Guthy-Jackson Charitable Foundation’s fifth NMO Roundtable Conference. Los Angelos, USA, 2012.
Chan K.H., Management of multiple sclerosis and neuromyelitis optica for the non-neurologists, 18th Hong Kong Medical Forum. 2013.
Chan K.H., Member of Organizing Committee of the 8th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Myasthenia Gravis and Pregnancy, Commissioned Training in Obstetrics and Gynaecology 2012/2013. 2013.
Chan K.H., Neuromyelitis Optica in Hong Kong Chinese, 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. 2012.
Chan K.H., Novel immunomodulation for neuroinflammation, Research Meeting, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2013.
Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Pregnancy in Myasthenia Gravis, Hospital Authority Commissioned Training. Hong Kong, 2013.
Chan K.H., Treatment of Central Nervous System Inflammatory Demyelinating Disorders, 24th Annual Scientific Meeting of the Hong Kong Neurological Society. 2012.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
QIAN W., Chan K.H., Chan Q. and Mak H.K.F., Assessment of normal-appearing brain tissue changes in multiple sclerosis using diffusion kurtosis imaging. , International Society of Magnetic Resonance in Medicine 22nd Annual Scientific Meeting and Exhibition, 2013. . 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Chan KH

List of Research Outputs

Chan K.H., Member of Organizing Committee , 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. Hong Kong, 2012.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chan K.H., Associate Editor, Open Journal of Immunology . 2012.
Chan K.H., Clinical Features, Diagnosis and Immunopathogenesis of Neuromyelitis Optica Spectrum Disorders , 2012.
Chan K.H., Co-Chairman of Organizing Committee of “Natalizumab in Clinical Practice and Certificate course”, co-organized by the Hong Kong Neurological Society and Hong Kong Multiple Sclerosis Society. Hong Kong, 2013.
Chan K.H., Expert consensus statements on the use of IVIG IN NEUROLOGY. , The Asia-Pacific IVIG Advisory Board. 3rd Edition. 2013.
Chan K.H., GRF Incentive Award, Univeristy Research Committee. 2012.
Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Chan K.H., Invited Chairmanship of Symposium XI: Aging Eyes of the 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Invited Speaker &Discussant, , The Guthy-Jackson Charitable Foundation’s fifth NMO Roundtable Conference. Los Angelos, USA, 2012.
Chan K.H., Management of multiple sclerosis and neuromyelitis optica for the non-neurologists, 18th Hong Kong Medical Forum. 2013.
Chan K.H., Member of Organizing Committee of the 8th International Symposium on Healthy Aging, Research Center for Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Hong Kong, 2013.
Chan K.H., Myasthenia Gravis and Pregnancy, Commissioned Training in Obstetrics and Gynaecology 2012/2013. 2013.
Chan K.H., Neuromyelitis Optica in Hong Kong Chinese, 1st Annual Scientific Meeting of the Hong Kong Multiple Sclerosis Society. 2012.
Chan K.H., Novel immunomodulation for neuroinflammation, Research Meeting, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2013.
Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Pregnancy in Myasthenia Gravis, Hospital Authority Commissioned Training. Hong Kong, 2013.
Chan K.H., Treatment of Central Nervous System Inflammatory Demyelinating Disorders, 24th Annual Scientific Meeting of the Hong Kong Neurological Society. 2012.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
QIAN W., Chan K.H., Chan Q. and Mak H.K.F., Assessment of normal-appearing brain tissue changes in multiple sclerosis using diffusion kurtosis imaging. , International Society of Magnetic Resonance in Medicine 22nd Annual Scientific Meeting and Exhibition, 2013. . 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Chan MMW

Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2001


Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004


List of Research Outputs

Mak J.C.W., Chu J.L., Yeung S.C., Chan M.M.W. and Ip M.S.M., Elevated plasma levels of growth differentiation factor (GDF)-15 in stable chronic obstructive pulmonary disease (COPD), Am. J. Respir. Crit. Care Med.. 2013, 187: A1526.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.


Researcher : Chan TCI

List of Research Outputs

Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chu L.W. and Chan F.H.W., Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study, Journal of the American Medical Directors Association. 2012, 13(9): 782-7.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Shea Y.F., Chan F.H.W., Woo P.C.Y. and Chu L.W., Functional status of older nursing home residents can affect the efficacy of influenza vaccination. , Journal of Gerontology. 2013, 68: 324-330.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chan F.H.W. and Chu L.W., Prevalence of anemia in Chinese nursing home older adults: Implication of age and renal impairment [Epub ahead of print], Geriatrics & Gerontology International. 2012.


Researcher : Chan TK

List of Research Outputs

Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Chan VNY

Project Title:Hepatitis B virus array for genotyping and mutation detection
Investigator(s):Chan VNY, Lai CL, Chan K, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2006


List of Research Outputs

Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Chan VSF

Project Title:Development of a humanized mouse systemic lupus erythematosus model for studying disease pathogenesis and evaluation of therapeutic treatment efficacy
Investigator(s):Chan VSF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Functional characterization of the novel C-type lectin-like receptor CLEC16A and its expression association in systemic lupus erythematosus
Investigator(s):Chan VSF, Lau WCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Molecular profiling of pathogenic dendritic cells development in systemic lupus erythematosus
Investigator(s):Chan VSF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012




Researcher : Chan WK

List of Research Outputs

WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.


Researcher : Chan YC

List of Research Outputs

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Chan YCC

Project Title:DPP-4 inhibition protects diabetes-induced impairment in EPC function and vascular repair
Investigator(s):Chan YCC, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Chan Y.C.C., Roy S., Huang Y., Khanna S. and Sen C.K., The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway, J Biol Chem. 2012, 287(49): 41032-43.


Researcher : Chan YH

List of Research Outputs

Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Chan YY

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
LIM A.I., Tang S.C.W., Chan Y.Y., Lai K.N. and Leung J.C.K., Chemokines Usage by Tubular Epithelial Cells in IgA Nephropathy: Role of TNF-α and Angiotensin II, J Am Soc Nephrol. 2012, 23: 854A.
Leung J.C.K., LIM A.I., Chan Y.Y., Tang S.C.W. and Lai K.N., Dual Blockade of Angiotensin II and Prorenin Receptors Ameliorates Podocytic Apoptosis in IgA Nephropathy through Inhibition of the Notch Signaling Pathway, J Am Soc Nephrol. 2012, 23: 322A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Chang SKR

List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Chang S.K.R., Mak H.K.F., Mak W. and Mok T.M.Y., Bithalamic stroke in a patient with Systemic Lupus Erythematosus positive antiphospholipid antibodies and warfarin use. , International Journal of Rheumatic Diseases.. 2012, 15(4): e76-77.
Chang S.K.R., Mak W., Cheung R.T.F. and Ho S.L., Perioperative ischemic stroke. In: Ischemic Stroke: symptoms, prevention and recovery., In: V Lakatos, B Somogyi, New York, Nova Science Publishers Inc, 2013, 191-207.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Chau KM

List of Research Outputs

Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin Suppresses Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of PKC-alpha Phosphorylation, Peritoneal Dialysis International . 2012, 32: S120.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin suppresses fibrotic processes in human peritoneal mesothelial cells through inhibition of PKC-alpha phosphorylation, 14th Congress of the International Society for Peritoneal Dialysis, Kuala Lumpur, Malaysia. 2012.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin inhibits epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells through inhibition of MAPK phosphorylation, ISN World Congress of Nephrology 2013.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.
Yung S.S.Y., Chau K.M., Zhang Q., Zhang C. and Chan D.T.M., Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy, PLoS One. 2013, e54501.


Researcher : Che H

List of Research Outputs

Che H. and Li G.R., Effects of Functional Transient Receptor Potential Channels on Adipogenesis and Proliferation in Human Preadipocytes, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 163.
Che H. and Li G.R., Effects of Functional Transient Receptor Potential Channels on Proliferation and Migration in Human Cardiac C-Kit+ Cells, 18th Medical Research Conference, Department of Medicine, HKU. 2013. 19(1): 23.


Researcher : Chen C

Project Title:Potential roles of fibroblast growth factor 21 (FGF21) in the regulation of thermogenesis by thyroid hormone in brown adipose tissue
Investigator(s):Chen C, Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2012


List of Research Outputs

Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.


Researcher : Chen JY

Project Title:The development of the common core course "From Health to Wellbeing"
Investigator(s):Chen JY, Chin WY
Department:Family Medicine and Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:01/2010


Project Title:Mind-body-spirit integrative training for stress management and prevention against junior physicians’ burnout
Investigator(s):Chen JY, Wong PY
Department:Family Medicine and Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:09/2010


Project Title:Exploration of suffering and wellbeing through visual narratives of illness AND What makes for a better doctor and good medical practice? – Perspectives from Film and Book Narratives
Investigator(s):Chen JY, Chan LC, Chan LK, Tsang JWH, Lam CLK, Fielding R, Chua SE, Leung PPY
Department:Family Medicine and Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:10/2010


Project Title:Developing resilience and enhancing wellbeing in medical students through a structured self-awareness programme The Art of Empathy: Using the Arts to Cultivate Empathy for Patients and Develop Self-awareness
Investigator(s):Chen JY, Chan LC, Potash JS
Department:Family Medicine and Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:10/2011


Project Title:Exploring the development of teachers who are recognized as role models of professional values and humanistic behaviour
Investigator(s):Chen JY, Yip LM
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:Development, implementation and preliminary evaluation of a longitudinal programme for early student experiential learning of professionalism
Investigator(s):Chen JY, Chin WY, Fung SCC
Department:Family Medicine and Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:08/2012


Project Title:7th Conference of the Asian Medical Education Association: Evaluation in Medical Education Present and Future; The impact of an art-making workshop on student empathy
Investigator(s):Chen JY
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


Project Title:An exploratory qualitative study of the illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis in the hospital or in the community
Investigator(s):Chen JY, Wong W, Tang SCW
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Chin W.Y., Chen J.Y., Wong K.K.D. and Chau T.W., Exploration of community teachers’ perceptions regarding community-based teaching and learning, 7th Asian Medical Education Associations Conference. 2013.


Researcher : Chen WH

Project Title:Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/2001


Project Title:A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003




Researcher : Chen Y

List of Research Outputs

Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.


Researcher : Cheng CW

Project Title:Potential oncogenic role of PIN1 in B-cell lymphoma
Investigator(s):Cheng CW, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2012


List of Research Outputs

Cheng C.W., Chow K.M., Pang R.W.C., Fok E.W.S., Kwong Y.L. and Tse E.W.C., PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin., The American Journal of Pathology. 2013, 182(3): 765-775.
Chow K.M., Ng L., LI H.S., Cheng C.W., LAM S.C., Yau T.C.C., Cheng P.N.M., Fan S.T., Poon R.T.P. and Pang R.W.C., Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma, Current Cancer Drug Targets. 2012, 12(9): 1233-1243.
Frontini M., Kukalev A., Leo E., Ng Y.M., Cervantes M., Cheng C.W., Holic , Dormann , Tse E.W.C., Pommier Y. and Yu C.C.P.V., The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment, Developmental Cell. 2012, 23(2): 356–370.


Researcher : Cheng KY

Project Title:The role of APPL2 in the regulation of insulin secretion and glucose homeostasis in mice
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2013


List of Research Outputs

Cao M., Mao Z., Kam C., Xiao N., Cao X., Shen C., Cheng K.Y., Xu A., Lee K.M., Jiang L. and Xia J., Pick1 and ica69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. , PLOS Biology. 2013, 11(4).
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Cheng K.Y., APPL1 in the regulation of insulin secretion and actions, Gwanak Symposium Program 2013. 2013.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 promotes insulin secretion by up-regulating expression of exoytotic SNARE proteins via Akt dependent pathway in mice. , 7 th International Huaxia Congressof Endocrinology 2012.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 regulates insulin secretion in pancreatic beta cells. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.
Cheng K.Y., The adaptor protein APPL1 as a new therapeutic target for type 2 diabetes: molecular basis and physiological relevance., HK-Swiss Diabetes Scientific Seminar 2012. 2012.
Cheng K.Y., The potentiating effect of APPL1 on hepatic insulin action is regulated by ubiquitination. , Hong Kong Symposium Obesity and Diabetes 2013.. 2013.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.


Researcher : Cheng OY

List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.


Researcher : Cheng YY

Project Title:The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):Cheng YY, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2008




Researcher : Cheung AMS

Project Title:Dissecting Variable Chemotherapeutic Drug Sensitivities in Human Acute Myeloid Leukemia (AML) Based on Differential Signalling Profiles
Investigator(s):Cheung AMS, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:04/2013


Project Title:54th American Society of Hematology Annual Meeting and Exposition; Time Course Studies of the Progeny of Barcoded CD34+ Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2R&gamma-/- Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating
Investigator(s):Cheung AMS
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:12/2012
Completion Date:12/2012


List of Research Outputs

Chow C.H., Cheung A.M.S., Li R.A., Chan C.W.Y., So E.C.W. and Leung A.Y.H., The use of human induced pluripotent stem cells (hiPSC) for modeling blood disorders, Drug Discovery Today: Disease Models. 2012.


Researcher : Cheung B.M.Y.

Project Title:Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):Cheung BMY, Lam KSL, Sham PC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010
Completion Date:12/2012


Project Title:Does adrenomedullin reduce the inflammatory response caused by advanced glycation endproducts?
Investigator(s):Cheung BMY, Tan KCB, Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Does an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?
Investigator(s):Cheung BMY, Lam KSL, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Cost-effectiveness of testing for the HLA-B*5801 allele to prevent serious hypersensitivity reaction to allopurinol
Investigator(s):Cheung BMY, Cheung TT, Chau J, Lam MPS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:18th Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy; Serum Beta-2 Microglobulin Concentration Predicts Cardiovascular and All-cause Mortality
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs



Researcher : Cheung BMY

Project Title:Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):Cheung BMY, Lam KSL, Sham PC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010
Completion Date:12/2012


Project Title:Does adrenomedullin reduce the inflammatory response caused by advanced glycation endproducts?
Investigator(s):Cheung BMY, Tan KCB, Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Does an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?
Investigator(s):Cheung BMY, Lam KSL, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Cost-effectiveness of testing for the HLA-B*5801 allele to prevent serious hypersensitivity reaction to allopurinol
Investigator(s):Cheung BMY, Cheung TT, Chau J, Lam MPS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:18th Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy; Serum Beta-2 Microglobulin Concentration Predicts Cardiovascular and All-cause Mortality
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Chan L.S., Lau W.C.S., Kumana C.R. and Cheung B.M.Y., Utility of infrared thermography for screening febrile subjects, Hong Kong Medical Journal. 2013, 19: 109-115.
Cheung B.M.Y., American Journal of Hypertension , Editorial Board Member. 2013.
Cheung B.M.Y., Associate Editor, The Open Hypertension Journal. 2013.
Cheung B.M.Y., Current Management of hypertension in Asian countries, 2012 Mainland Medical Institutions Hypertension Management Exchange Forum, Hong Kong. 2012.
Cheung B.M.Y., Chan L.S., Lauder I.J. and Kumana C.R., Detection of body temperature with infrared thermography: accuracy in detection of fever, Hong Kong Medical Journal. 2012, 18 (4) Suppl 3: 31-34.
Cheung B.M.Y., Editor-in-Chief, The Open Diabetes Journal. 2013.
Cheung B.M.Y., Editor, Cardiology Research. 2013.
Cheung B.M.Y., Editorial Advisory Board Member, Expert Review of Clinical Pharmacology. 2013.
Cheung B.M.Y., Editorial Board Member , The Open Hypertension Journal. 2013.
Cheung B.M.Y., Editorial Board Member, CIP Journal of Cardiology . 2013.
Cheung B.M.Y., Editorial Board Member, Diabetes, Metabolic syndrome and Obesity. 2013.
Cheung B.M.Y., Editorial Board Member, Journal of the Hong Kong College of Cardiology. 2013.
Cheung B.M.Y., Editorial Board Member, Journal of the Royal Society of Medicine Cardiovascular Science. 2013.
Cheung B.M.Y., Editorial Board Member, Therapeutic Advances in Drug Safety. 2013.
Cheung B.M.Y., Editorial advisor, Cardiovascular Risk Digest. 2013.
Cheung B.M.Y., Executive Editor, British Journal of Clinical Pharmacology. 2013.
Cheung B.M.Y., Hypertensive crisis, Hong Kong College of Physicians Annual Scientific Meeting. 2012.
Cheung B.M.Y., Samaranayake N.R. and Chui W.C.M., Medication Incidents related to technology in a University-affiliated general hospital in 2006-2010, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults, Clin Nutr . 2012, S0261-5614(12)00281-6.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among adults, Journal of the Hong Kong College of Cardiology. Young Investigator Award Second Prize at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 51.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., Reduced serum beta-trace protein is associated with metabolic syndrome, Atherosclerosis. 2013, 227(2): 404-7.
Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality in people with diabetes, Eur J Endocrinol . 2013, 169(1): 1-7.
Cheung C.L., Tan K.C.B., Lam K.S.L. and Cheung B.M.Y., The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: A structural equation modeling approach., Journal of Clinical Endocrinology and Metabolism. 2013.
Cheung T.T., Cheung C.L. and Cheung B.M.Y., Serum Ferritin Transferrin Saturation were Independently Associated with Pre-diabetes among U.S. Adults, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Intensive glucose lowering for diabetes: long-term impact on absolute mortality. , Presented at the 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Evalution of Beers and Stopp/Start Criteria for Prescribing Appropriateness Among Hong Kong Elderly, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 60.
Lam M.P.S., Yeung C.K. and Cheung B.M.Y., Pharmacogenetics of Allopurinol-Making an Old Drug Safer, The Journal of Clinical Pharmacology. 2013, 53(7): 675-679.
Leng X.Y., Chen X.Y., Chook P., Xiong L., Lin W.H., Liu J.Y., Tomlinson B., Thomas G.N., Lam T.H., Lam K.S.L., Cheung B.M.Y. and Wong K.S., Association between metabolic syndrome and carotid atherosclerosis: A community-based study in Hong Kong, Metabolic Syndrome and Related Disorders. 2013, 11(2): 109-14.
Leng X.Y., Chen X.Y., Chook P., Xiong L., Lin W.H., Tomlinson B., Thomas G.N., Lam T.H., Lam K.S.L., Cheung B.M.Y. and Wong K.S., Correlation of Large Artery Intracranial Occlusive Disease With Carotid Intima-Media Thickness and Presence of Carotid Plaque, Stroke. 2013, 44(1): 68-72.
Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.
Liao S., Wong P.F., O W.S., Cheung B.M.Y. and Tang F., Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat, 2012, 31-37.
Ong K.L., WU B.J., Cheung B.M.Y., Barter P.J. and Rye K.A., Arthritis: Its Prevalence, Risk Factors, and Association with Cardiovascular Diseases in the United States, 1999-2008, Annals of Epidemiology. 2013, 23(2): 80-6.
Ong K.L., Allison M.A., Cheung B.M.Y., Wu B.J., Barter P.J. and Rye K.A., C-reactive protein trends and associations with total mortality in United States adults between 1999-2010, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 53.
Ong K.L., Allison M.A., Cheung B.M.Y., Wu B.J., Barter P.J. and Rye K.A., Trends in C-reactive protein levels in US adults from 1999 to 2010., American Journal of Epidemiology. 2013, 177(12): 1430-42.
SAMARANAYAKE N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of the discovery of medication errors in a tertiary hospital in Hong Kong., International Journal of Clinical Pharmacy. 2013, 35(3): 432-8.
Samaranayake N.R., Cheung S.T.D., Cheng K., Lai K., Chui C.M.W. and Cheung B.M.Y., A pharmacy-led bar-code assisted medication administration system – changes to the pharmacy process and user attitudes., Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wong H.K., Ong K.L., Leung Y.H., Lam T.H., Thomas G.N., Lam K.S.L. and Cheung B.M.Y., A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels, Journal of the Hong Kong College of Cardiology. Presented at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 56.
Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.


Researcher : Cheung CL

Project Title:Genome-Wide Association and Gene-and-Environment Interaction Studies of Vitamin D Insufficiency in Southern Chinese
Investigator(s):Cheung CL, Kung AWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:American Heart Association scientific session 2012; Beta-trace Protein and Beta-2-microglobulin are Independent Predictors of All-cause and Cardiovascular Mortality in US Adults
Investigator(s):Cheung CL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2012


Project Title:Identification of susceptibility locus of Stevens-Johnson Syndrome and Toxic Epidermal Necrosis in Hong Kong Chinese
Investigator(s):Cheung CL, Cheung BMY, Wong ICK, Sham PC, Chan CYJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults, Clin Nutr . 2012, S0261-5614(12)00281-6.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among adults, Journal of the Hong Kong College of Cardiology. Young Investigator Award Second Prize at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 51.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., Reduced serum beta-trace protein is associated with metabolic syndrome, Atherosclerosis. 2013, 227(2): 404-7.
Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality in people with diabetes, Eur J Endocrinol . 2013, 169(1): 1-7.
Cheung C.L., Tan K.C.B., Lam K.S.L. and Cheung B.M.Y., The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: A structural equation modeling approach., Journal of Clinical Endocrinology and Metabolism. 2013.
Cheung T.T., Cheung C.L. and Cheung B.M.Y., Serum Ferritin Transferrin Saturation were Independently Associated with Pre-diabetes among U.S. Adults, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Cheung KF

List of Research Outputs

Chan D.T.M., Cheung K.F., Yim A.S.Y., Yap Y.H.D. and Yung S.S.Y., Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis, Journal of the American Society of Nephrology. 2012, 23: 567A.
HO S.K., Yung S.S.Y., Cheung K.F., Tse W.W. and Chan D.T.M., Anti-dsDNA antibodies induce epithelial-to-mesenchymal transition and fibrotic processes in human proximal renal tubular epithelial cells, ASN Kidney Week 2012. 338A.
Yung S.S.Y., HO S.K., Cheung K.F. and Chan D.T.M., Anti-dsDNA antibodies induce cell activation and fibronectin synthesis in human renal proximal tubular epithelial cells., ISN World Congress of Nephrology 2013.


Researcher : Cheung MS

Project Title:Dissecting Variable Chemotherapeutic Drug Sensitivities in Human Acute Myeloid Leukemia (AML) Based on Differential Signalling Profiles
Investigator(s):Cheung AMS, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:04/2013


Project Title:54th American Society of Hematology Annual Meeting and Exposition; Time Course Studies of the Progeny of Barcoded CD34+ Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2R&gamma-/- Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating
Investigator(s):Cheung AMS
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:12/2012
Completion Date:12/2012


List of Research Outputs



Researcher : Cheung RTF

Project Title:Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:04/2005


Project Title:Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2009


Project Title:Evaluation of key mechanisms of brain injury and of a novel hemostatic treatment in a rat model of hypertensive intracerebral hemorrhage
Investigator(s):Cheung RTF, Ellis-Behnke RG, So KF, Wu EX
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:Transplantation of neural stem cells in a rat model of intracerebral hemorrhage
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2010


Project Title:A pilot study of silent brain infarcts in healthy hypertensive elderly Chinese: the first 100 subjects
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:Adverse effects of up-regulated adiponectin level on immune system in mice stroke models. Part I: effects of exogenous PPARgamma antagonist (BADGE) in wide type and transgenic mice.
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2013


List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Chang S.K.R., Mak W., Cheung R.T.F. and Ho S.L., Perioperative ischemic stroke. In: Ischemic Stroke: symptoms, prevention and recovery., In: V Lakatos, B Somogyi, New York, Nova Science Publishers Inc, 2013, 191-207.
Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2013.
Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2013.
Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2013.
Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2012.
Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2013.
Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2013.
Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2013.
Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2013.
Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2013.
Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2013.
Cheung R.T.F., Member of Organizing Committee, Eighth International Symposium on Healthy Aging: How to Age with Finesse, Research Centre of Heart, Brain, Hormone & Healthy Aging, Faculty of Medicine, HKU, 9-10 March 2013, Sheraton Hong Kong Hotel & Towers, Tsimshatsui, Hong Kong. 2013.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Gao J., TAN A., Chang C., Hung Y.S., Cheung R.T.F. and Zhang Z., Decreased coherence of gamma-band EEG activity in MBSR meditation states, 19th Annual Meeting of the Organization for Human Brain Mapping (OHBM2013). 2013.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition, Serial B. 2013.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Mak H.K.F. and Lee T.M.C., Relevance of short-range connectivity to brain compensation and cognitive efficiency in healthy and pathological ageing: a combined functional magnetic resonance imaging and tractography study on prospective memory, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 19.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.
XIE B., ZHANG M., Mak H.K.F. and Cheung R.T.F., Blood pressure variability and silent small vessel cerebrovascular lesions in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 534.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Junior Investigator's Award for poster, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 22: 239.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Lack of association between brachial-ankle pulse wave velocity and white matter hyperintensities in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 239.


Researcher : Cheung TK

List of Research Outputs

Tan V.P.Y., Cheung T.K., Wong W.M., Pang R.W.C. and Wong B.C.Y., Treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot study, World Journal of Gastroenterology. 2012, 18(42): 6127-6133.


Researcher : Cheung TT

List of Research Outputs

Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults, Clin Nutr . 2012, S0261-5614(12)00281-6.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among adults, Journal of the Hong Kong College of Cardiology. Young Investigator Award Second Prize at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 51.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., Reduced serum beta-trace protein is associated with metabolic syndrome, Atherosclerosis. 2013, 227(2): 404-7.
Cheung T.T., Cheung C.L. and Cheung B.M.Y., Serum Ferritin Transferrin Saturation were Independently Associated with Pre-diabetes among U.S. Adults, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.


Researcher : Cheung WWW

List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.


Researcher : Cheung YY

Project Title:Impact of newly identified type 2 diabetes susceptibility loci on the risk of coronary artery disease among patients with T2DM.
Investigator(s):Cheung YY, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013




Researcher : Chim JCS

Project Title:FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Lee Hysan Foundation - General Award
Start Date:07/2008


Project Title:Functional study of the impact of hypermethylation of tumor suppressive micro-RNA in myeloma stem cells
Investigator(s):Chim JCS, Liang RHS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:Methylation of miR-129 in hematological cancers
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:Study of methylation of microRNA in mantle cell lymphoma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Methylation of miR-224 in haematological cancers
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Genetic study (FISH study) for personalized treatment of multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2012


Project Title:Epigenetic silencing of tumour suppressor miR-212/132 cluster in Philadelphia-negative myeloproliferative neoplasm
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Cheung W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital, Intern Med J.. 2012, [Epub ahead of print].
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.
Chim J.C.S., Aberrant DNA Methylation of MicroRNA in Cancer: the lesson from multiple myeloma, 7th International Conference on Genomics & Bio-IT APAC 2012, jointly organized by BGI and Giga Science, Hong Kong. 2012.
Chim J.C.S., Aberrant DNA Methylation of MicroRNA in Cancer: the lesson from multiple myeloma, China•Guangzhou Hematology Frontier Forum, organized by Sun Yat-sen Institute of Hematology in Guangzhou, China. 2012.
Chim J.C.S., American Journal of Molecular Biology, 2012.
Chim J.C.S., American Journal of Translational Research, 2013.
Chim J.C.S., Blood Cancer Journal (http://www.nature.com/bcj/about/index.html#Editors) , 2013.
Chim J.C.S., Bone Marrow Transplantation (impact factor :3.6) , 2013.
Chim J.C.S., Cancer Reports (BioMed Best), 2013.
Chim J.C.S., Carcinogenesis (impact factor :5.4) , 2013.
Chim J.C.S., Chinese Medical Journal. 2012.
Chim J.C.S., Clinical Epigenetics, 2012.
Chim J.C.S., Epigenomics (impact factor:3.429), 2012.
Chim J.C.S., Frontiers in Epigenomics, 2012.
Chim J.C.S., Health (http://www.scirp.org/journal/health), 2012.
Chim J.C.S., Hematology and Leukemia (Herbert Open Access Journals), 2013.
Chim J.C.S., Choi P.T. and Lee W.K., Hodgkin's lymphoma as a second cancer in multiple myeloma never exposed to lenalidomide., Annals Hematol. 2012, [Epub ahead of print].
Chim J.C.S., International Journal of Health, 2013.
Chim J.C.S., International Journal of Health . 2013.
Chim J.C.S., International Journal of Oncology (impact factor: 2.57) , 2013.
Chim J.C.S., Journal of Genetics Study, 2013.
Chim J.C.S., Journal of Hematology Oncology (IF: 3.99), 2013.
Chim J.C.S., Journal of Life Medicine, 2013.
Chim J.C.S., Journal of Translational Medicine (impact factor: 3.5) , 2012.
Chim J.C.S., Journal of Transplantation Technology, 2013.
Chim J.C.S., Molecular Biology and Genetic Engineering , 2013.
Chim J.C.S. and Chan Y.E.T., Oligoclonal reconstitution masquerading as myeloma relapse, Ann Hematol. 2012, [Epub ahead of print].
Chim J.C.S., Optimal Therapy for Relapsed/ Refractory Myeloma, 4th International Hematologic Malignancies Conference: Bridging the Gap 2013, organized by MD Anderson Cancer Center, Hong Kong. 2013.
Chim J.C.S., PLoS ONE (impact factor: 4.41), 2012.
Chim J.C.S., Scientifica, 2013.
Chim J.C.S., The Asia-Pacific Journal of Oncology and Hematology. 2013.
Chim J.C.S., The Bortezomib-based induction therapy for Transplant-eligible myeloma in Hong Kong - The Next Clinical Questions!, 14th International Myeloma Workshop, organized by Organzing Committee of the 14th International Myeloma Workshop, Kyoto, Japan. 2013.
Chim J.C.S., The Hong Kong Medical Diary. 2013.
Chim J.C.S., The Open Leukemia Journal. 2012.
Chim J.C.S., The Open Pathology Journal. 2013.
Chim J.C.S., The Open Surgical Oncology Journal. 2013.
Chim J.C.S., The Open Translational Medicine Journal. 2012.
Chim J.C.S., Translational Oncology (impact factor: 2.40), 2013.
Chim J.C.S., Transplantation Technology . 2013.
Chim J.C.S., 《白血病•淋巴瘤》雜誌 , 2013.
Fernández D.E. .L.A.R.R.E.A., Kyle R.A., Durie B.G., Ludwig H., Usmani S., Vesole D.H., Hajek R., San Miguel J.F., Sezer O., Sonneveld P., Kumar S.K., Mahindra A., Comenzo R., Palumbo A., Mazumber A., Anderson K.C., Richardson P.G., Badros A.Z., Caers J., Cavo M., Leleu X., Dimopoulos M.A., Chim J.C.S., Schots R., Noeul A., Fantl D., Mellqvist U.H., Landgren O., Chanan-Khan A., Moreau P., Fonseca R., Merlini G., Lahuerta J.J., Bladé J., Orlowski R.Z. and Shah J.J., Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group, Leukemia. 2012, [Epub ahead of print].
Kwong Y.L., Kim W.S., Lim S.T., Kim S.J., Tang T., Tse E.W.C., Leung A.Y.H. and Chim J.C.S., SMILE for natural killer (NK)/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group, Blood. 2012, 120(15): 2973-2980.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor., American Journal of Hematology. 2013, 88(6): 485-491.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S.C., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Relapses of acute leuekmia after allogeneic hematopoietic stem cell transplantation: second transplantation with reduced intensity conditioning from the original donor, Am J Hematol. 2013, in press.
Wang L...Q., Liang R. and Chim J.C.S., Methylation of tumor suppressor microRNAs: Lessons from lymphoid malignancies, Expert Review of Molecular Diagnostics. 2012, 12(7): 755-765.
Wong K.Y., Yim R.L.H., Kwong Y.L., Leung C.Y., Hui P.K., Cheung F., Liang R.H.S., Jin D.Y. and Chim J.C.S., Epigenetic inactivation of the MIR129-2 in hematological malignancies, J Hematol Oncol. 2013, 6:16.
Xu C., Fu H., Gao L., Wang L., Wang W., Li J., Li Y., Dou L., Gao X., Luo X., Jing Y., Chim J.C.S., Zheng X. and Yu L., BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia, Oncogene. 2012, [Epub ahead of print].
Yim R.L.H., Kwong Y.L., Wong K.Y. and Chim J.C.S., DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas, Frontiers in non-coding RNA. 2012, 2:233.


Researcher : Chin WY

Project Title:The epidemiology and natural history of depressive disorders in primary care
Investigator(s):Chin WY, Lam CLK, Lo YCY, Fong DYT, Lam TP, Lee PWH
Department:Med - Family Medicine Unit
Source(s) of Funding:Commissioned Research on Mental Health Policy and Services
Start Date:05/2010


Project Title:Exploration of Teachers' Views and Perceptions regarding the Structure, Curriculum Content and Assessment of Community-based Learning in Undergraduate Family Medicine
Investigator(s):Chin WY, Chen JY, Wong KKD
Department:Family Medicine and Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:12/2011
Completion Date:11/2012


Project Title:Evaluation of the health related quality of life of patients with urinary incontinence and validation of the ICIQ-UI (SF)
Investigator(s):Chin WY, Lam CLK
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Evaluation in Medical Education: Present and The Future; Exploration of community teachers' perceptions regarding community-based teaching and learning
Investigator(s):Chin WY
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013




Researcher : Chong BH

List of Research Outputs

Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Chow CH

List of Research Outputs

Chow C.H., Cheung A.M.S., Li R.A., Chan C.W.Y., So E.C.W. and Leung A.Y.H., The use of human induced pluripotent stem cells (hiPSC) for modeling blood disorders, Drug Discovery Today: Disease Models. 2012.


Researcher : Chow WS

List of Research Outputs

Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Yuen M.M.A., Chow W.S., Fong H.Y. and Lam K.S.L., Skin autofluorescence is associated with microvascular complications in type 2 diabetes, The 48th Annual Meeting of the European Association for the Study of Diabetes, 29 Sept – 6 Oct 2012, Berlin, Germany. 2012.


Researcher : Chow YY

List of Research Outputs

FU Q.L., Chow Y.Y., Sun S.J., Zeng Q.X., Li H.B., Shi J.B., Sun Y.Q., Wen W., Tse H.F., Lian Q. and Xu G., Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Rebalance Th1/th2 And Up-regulate Regulatory T Responses On Peripheral Blood Mononuclear Cells From Allergic Rhinitis Patients, Allergy. Wiley-Blackwell, 2012, Aug 1: doi: 10.1111/j.1398-9995.2012.02875.x..


Researcher : Choy CBY

List of Research Outputs

Kwan L.P., Choy C.B.Y., Chan D.T.M., Suen W.S. and Yap Y.H.D., Successful treatment of pulmonary rhizopus infection with surgical resection and posaconazole in a renal transplant recipient, Nephrology (Carlton). 2013, 18(1): 74-5.


Researcher : Chu LW

Project Title:A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):Chu LW, Lam KSL, Lee PWH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2003


List of Research Outputs

CHIU P.W., Chan Q., Chu L.W. and Mak H.K.F., 31P Magnetic Resonance Spectroscopy on normal aging human brain at 3.0Tesla. , 26th International Symposium on Cerebral Blood Flow, Metabolism and Function & 11th International Conference on Quantification of Brain Function with PET, 2013. . 2013.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chu L.W. and Chan F.H.W., Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study, Journal of the American Medical Directors Association. 2012, 13(9): 782-7.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Shea Y.F., Chan F.H.W., Woo P.C.Y. and Chu L.W., Functional status of older nursing home residents can affect the efficacy of influenza vaccination. , Journal of Gerontology. 2013, 68: 324-330.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chan F.H.W. and Chu L.W., Prevalence of anemia in Chinese nursing home older adults: Implication of age and renal impairment [Epub ahead of print], Geriatrics & Gerontology International. 2012.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition, Serial B. 2013.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Mak H.K.F. and Lee T.M.C., Relevance of short-range connectivity to brain compensation and cognitive efficiency in healthy and pathological ageing: a combined functional magnetic resonance imaging and tractography study on prospective memory, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 19.
Mak H.K.F., QIAN W., Yau K.K.W. and Chu L.W., Combination of quantitative MR hippocampal volumetry and arterial spin labeling MR perfusion in discriminating Alzheimer’s disease and cognitively normal older adults in a Hong Kong Chinese cohort. , American Roentgen Ray Society, 2013.. 2013.
Mak H.K.F., Chan Q., Zhang Z., Petersen E., Qiu D., Zhang L., Yau K.K.W., Chu L.W. and Golay X., Pulsatile Arterial Spin Labeling in differentiating Alzheimer's disease and cognitively normal elderly adults in a Chinese cohort. , Alzheimer’s Association International Conference 2012 . 2012.
Shea Y.F., Chau K.M., Hung I.F.N. and Chu L.W., Strongyloidiasis in a nonagenarian who previously worked in conservancy services, Hong Kong Medical Journal . 2013, 19(1): 74-6.
ZHANG L., Chang R.C.C., Chu L.W. and Mak H.K.F., Current neuroimaging techniques in Alzheimer's disease and applications of animal models. American Journal of Nuclear Medicine and Molecular Imaging., 2012, 2(3): 386-404.


Researcher : Chu PCM

List of Research Outputs

Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatol Curr Res. 2013, S5: 002.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatology: Current Research. OMICS Publishing Group, 2013, S5: 002.


Researcher : Chung ACK

Project Title:Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):Chung ACK, Lan HY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2008




Researcher : Feng Z

Project Title:30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):Feng Z
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2000




Researcher : Fong HY

List of Research Outputs

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Yuen M.M.A., Chow W.S., Fong H.Y. and Lam K.S.L., Skin autofluorescence is associated with microvascular complications in type 2 diabetes, The 48th Annual Meeting of the European Association for the Study of Diabetes, 29 Sept – 6 Oct 2012, Berlin, Germany. 2012.


Researcher : Fung JYY

List of Research Outputs

Chan S.C., Fan S.T., Chok K.S.H., Sharr W.W., Dai W.C., Fung J.Y.Y., Chan K.Y., Balsarkar D.J. and Lo C.M., Increasing the recipient benefit/donor risk ratio by lowering the graft size requirement for living donor liver transplantation, Liver Transplantation. 2012, 18(9): 1078-1082.
Cheung T.T., Ho C.L., Lo C.M., Chen S., Chan S.C., Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Sharr W.W., Yau T.C.C., Poon R.T.P. and Fan S.T., 11C-acetate and 18F-FDG PET/CT for clinical staging and selection of patients with hepatocellular carcinoma for liver transplantation on the basis of Milan criteria: surgeon's perspective, The Journal of Nuclear Medicine. 2013, 54(2): 192-200.
Cheung T.T., Chan S.C., Ho C.L., Chok K.S.H., Chan A.C.Y., Fung J.Y.Y., Chen S., Poon R.T.P., Fan S.T. and Lo C.M., 11C-acetate and 18F-FDG dual tracer PET scan with contrast CT provide the most accurate histopathology prediction in HCC patients - a study of explant histopathology in the model of liver transplantation (Poster Presentation), Liver Meeting 2012, the 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA, 9-13 November 2012. Abstract in Hepatology. 2012, 56(Suppl S1): 833A.
Cheung T.T., Fan S.T., Chan S.C., Chok K.S.H., Chu S.K.F., Jenkins C.R., Lo C.L.R., Fung J.Y.Y., Chan A.C.Y., Sharr W.W., Tsang S.H.Y., Dai W.C., Poon R.T.P. and Lo C.M., High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients, World Journal of Gastroenterology. 2013, 19(20): 3083-3089.
Chok K.S.H., Chan S.C., Fung J.Y.Y., Cheung T.T., Chan A.C.Y., Fan S.T. and Lo C.M., Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores, Hepatobiliary & Pancreatic Diseases International. 2013, 12(3): 256-262.
Fung J.Y.Y., Yuen R.M.F., Lai C.L. and Ng I.O.L., Do statins reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis B?, Hepatobiliary Surgery and Nutrition. 2013, 2(1): 34-6.
Fung J.Y.Y., Lee C.K., Chan M., Seto W.K.W., Lai C.L. and Yuen R.M.F., High prevalence of non-alcoholic fatty liver disease in the Chinese – results from the Hong Kong liver health census. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands 24–28 April 2013, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S538.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Levels of HBV DNA and not HBsAg are associated with biochemical flares after HBeAg seroconversion, Hepatology International. 2012, 6: 52.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Chan A.C.Y., Sharr W.W., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B – long term outcome. (Oral presentation at the Transplant Plenary II Session of the 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 11, 2012), Hepatology. 2012, 56(S1): 196A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Yuen R.M.F., Chok K.S.H., Sharr W.W., Chan A.C., Cheung T.T., Seto W.K.W., Fan S.T., Lai C.L. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B, American Journal of Gastroenterology. 2013, 108(6): 942-8.
Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.
Fung J.Y.Y., Yuen R.M.F. and Lai C.L., The role of steatosis in HBsAg seroclearance for patients with chronic hepatitis B infection: fact or fiction?, Digestive Diseases and Sciences. 2013, 58(1): 20-2.
Fung J.Y.Y. and Yuen R.M.F., This is hepatitis - it is closer than you think., Indian J Med Res. 2012, 136(1): 3-6.
Kim B.K., Fung J.Y.Y., Yuen R.M.F. and Kim S.U., Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives, World Journal of Gastroenterology. 2013, 19(12): 1890–1900.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Fung J.Y.Y., Yuen R.M.F. and Lai C.L., Future prevention and treatment of chronic hepatitis B infection. , J Clin Gastroenterol. 2012, 46(9): 725-34.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B surfact antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 257.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serologic and virologic outcomes of tenofovir in Asian chronic hepatitis B patients with prior nucleoside analogue exposure. (Poster presentation at the 63rd) Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 10, 2012, Hepatology. 2012, 56(S1): 415A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Seto W.K.W., Lam Y.F., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen levels during five years entecavir therapy in Asian chronic hepatitis B patients., The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S314.
Seto W.K.W., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B monoinfection, Hepatology International. 2013, 7(2): 327-34.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.


Researcher : GAO Y

List of Research Outputs

GAO Y., Li L.S.W., Chau L.H., Lo Y., Lau W.C.S. and Mok T.M.Y., Assessment of autonomic function in patients with a history of neuropsychiatric lupus, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.


Researcher : Gao J

Project Title:The relevance of brain connectivity in resting, alert and meditation states: a concurrent EEG/fMRI study
Investigator(s):Gao J, Sik HH, Hung YS
Department:Centre of Buddhist Studies
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Feng S.T., Cui M.C., Gao J., Wu B.X., Sha W. and Huang B., Image-derived arterial input function in dynamic positron emission tomography-computed tomography: a method using both positron emission tomographic and computed tomographic images., J Comput Assist Tomogr. . 2012, 36: 726-767.
Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition, Serial B. 2013.


Researcher : Gao RY

List of Research Outputs

Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Gu P

List of Research Outputs

Gu P. and Xu A., Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction, In: Zhenqi Liu, Rev Endocr Metab Disord. US, Springer US, 2013, 14: 49-58.


Researcher : Guo Y

List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.


Researcher : HO SK

List of Research Outputs

HO S.K., Yung S.S.Y., Cheung K.F., Tse W.W. and Chan D.T.M., Anti-dsDNA antibodies induce epithelial-to-mesenchymal transition and fibrotic processes in human proximal renal tubular epithelial cells, ASN Kidney Week 2012. 338A.
Yung S.S.Y., HO S.K., Cheung K.F. and Chan D.T.M., Anti-dsDNA antibodies induce cell activation and fibronectin synthesis in human renal proximal tubular epithelial cells., ISN World Congress of Nephrology 2013.


Researcher : Han L

List of Research Outputs

Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.


Researcher : Ho AYY

List of Research Outputs

Cheung E., Bow H.Y.C., Loong C., Lee K.K., Ho A.Y.Y., Soong S.S., Chan Y.Y. and Kung A.W.C., A secular increase in BMD in Chinese women., Journal of Bone and Mineral Metabolism. 2013.


Researcher : Ho JCM

Project Title:MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:07/2005


Project Title:A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):Ho JCM, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2007


Project Title:A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2007


Project Title:The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Lee Wing Tat Fund
Start Date:08/2007


Project Title:A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:11/2007


Project Title:A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2008


Project Title:A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:12/2008


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Hong Kong Lung Foundation Research Grant
Start Date:02/2009


Project Title:Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2009


Project Title:Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2010


Project Title:Study on systemic and airway cytokines and oxidative stress in patients undergoing haemopoietic stem cell transplantation (HSCT)
Investigator(s):Ho JCM, Lie AKW, Au WY, Liang RHS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:09/2010


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:03/2011


Project Title:A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2011


Project Title:Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2011


Project Title:In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):Ho JCM, Lam SK
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2012


Project Title:Gene expression profiling for potential resistance mechanisms of lung cancer to arsenic trioxide
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012
Completion Date:04/2013


List of Research Outputs

Ho J.C.M., Bronchogenic carcinoma: epidemiology, investigations and treatment, Post-registration certificate course in respiratory nursing. Institute of Advanced Nursing Studies, Hospital Authority. 5 July. 2012.
Ho J.C.M., Personalized chemotherapy in non-small cell lung cancer, 17th Congress of the Asian Pacific Society of Respirology, 14th Dec. 2012.
Ho J.C.M., Raising COPD treatnent expectation, CME Program for Physicians at Baptist Hospital, Hong Kong, 5th Nov. 2012.
Ho J.C.M. and Lam S.K., Suppression of Thymidylate Synthase by Arsenic Trioxide in Mesothelioma Cell Lines, Asian Pacific Society of Respirology. 2012.
Ho J.C.M., Treatment of non-small cell lung cancer in the era of targeted therapy, Advances in Lung Cancer. 2012, 1: 1-4.
Lam Y., Sze C.W., Tong Y., Tang S.C.W., Ho J.C.M., Liao Q.X., Lin X. and Zhang Y., Research on the allelopathic potential of wheat, In: Y Lam, CW Sze, Y Tong, TB Ng, Tang CW, Ho CW, QX Liao, X Lin, YB Zhang*, Agricultural Sciences. 2012, 3: 979-985.
Li Y., Lam S.K., Mak J.C.W., Zheng C. and Ho J.C.M., Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer, Lung cancer. 2013.
Li Y., Lam S.K. and Ho J.C.M., The Role of Erlotinib-induced Autophagy in Non-Small Cell Lung Carcinoma, Asian Pacific Society of Respirology. 2012.
O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.
O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., Adrenomedullin as a biomarker for tubal ectopic pregnancy – new evidence from adrenomedullin function in the nasal ciliary epithelium. Society for Reproduction and fertility, Edinburgh, United Kingdom, #O019, July 2012.
O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100(2): 459-463.
Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.
Wong K.Y.M., Lam C.L.D., Ip M.S.M. and Ho J.C.M., EBUS-TBNA gives adequate tissue information on cell type in lung cancer, Hong Kong Med.J.. 2013, 19 (Suppl. 1): 51.
Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.
Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.
Zheng C., Lam S.K. and Ho J.C.M., Reactive Oxidative Species Take a Pivotal Role in Arsenic Trioxide induced Cell Death in Small Cell Lung Cancer Cells Via Regulation of Notch1 and HIF-1 a, Asian Pacific Society of Respirology. 2012.


Researcher : Ho JCY

List of Research Outputs

Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Ho SL

Project Title:Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):Ho SL, Song Y, Wang Y
Department:Medicine
Source(s) of Funding:Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:04/2007


List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Chang S.K.R., Mak W., Cheung R.T.F. and Ho S.L., Perioperative ischemic stroke. In: Ischemic Stroke: symptoms, prevention and recovery., In: V Lakatos, B Somogyi, New York, Nova Science Publishers Inc, 2013, 191-207.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Ho S.L., Associate Editor, Clinical Neuropharmacology. USA, Lippincott Williams&Wilkins, 2013.
Ho S.L., Editorial Board Member, Brain and Behavior. USA, Wiley Publishers Inc, USA, 2013.
Ho S.L., Section Editor, Translational Neruodegeneration. UK, BioMed Central, 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
Li M., Kwan S.H., Bao S., Yang W., Ho S.L., Song Y. and Sham P.C., Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies, PLos Genet. 2013, 9(1): e1003143.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Ho WL

Project Title:Pathological role of R1441G mutant leucine-rich repeat kinase 2 (LRRK2) in ubiquitin-proteasomal system and mitochondrial autophagy in Parkinson's disease
Investigator(s):Ho WL, Ho SL, Chan KH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2011


List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.


Researcher : Ho WM

Project Title:UCP4 is a target effector of NF-kappaB c-Rel pro-survival pathway against oxidative stress
Investigator(s):Ho WM, Ho SL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2011
Completion Date:05/2013


List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.


Researcher : Hon FKS

List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Hoo RLC

Project Title:The role of adipocyte fatty acid binding protein in association with autophagy in lipids-induced endoplasmic reticulum stress
Investigator(s):Hoo RLC, Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2011


Project Title:Adipocyte-derived small lipid-binding proteins as a mediator of obesity-induced cardiac dysfunction and heart failure
Investigator(s):Hoo RLC, Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


Project Title:Interplay between adipocyte fatty acid binding protein and endoplasmic reticulum stress in toxic lipids-induced inflammation in macrophages
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of adipocyte fatty acid binding protein in diet-induced obesity
Investigator(s):Hoo RLC, Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.
Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Lam K.S.L., Hoo R.L.C., LEE P.C. and Xu A., A-FABP deficiency protects against diet induced steatohepatitis in mice, 95th Endocrine Society Annual Meeting and Expo. 2013.
Lin Z., Tian H., Lam K.S.L., Lin S., Hoo R.L.C., Konishi M., Itoh N., Wang Y., Bomstein S.R., Xu A. and Li X., Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice, Cell Metabl . 2013, 17: 779-789.
Ye H., Zhang J., Xu A. and Hoo R.L.C., Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone, PLoS One. 2013, 8: e65543.


Researcher : Hsu ASJ

List of Research Outputs

Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.


Researcher : Hu HC

Project Title:A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):Hu HC, Lam CLK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:10/1998




Researcher : Huang FY

Project Title:AACR-JCA Joint Conference: Breakthroughs in Basic and Translational Cancer Research; Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice
Investigator(s):Huang FY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2013


List of Research Outputs

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.


Researcher : Huang Z

List of Research Outputs

Kong K.Y., Tang V.H.M., Huang Z., Hinnebusch A.G., Jin D. and Wong C.M., Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal slicing efficiency, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2013. 2012.


Researcher : Hui CK

Project Title:Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):Hui CK, Liang RHS, Lau G, Lie AKW
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Hui X

Project Title:Sirt1 in adipocyte as a regulator of adipose tissue senescence and systemic energy homeostasis
Investigator(s):Hui X, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:Cell Symposia: Immunometabolism---from Mechanisms to Therapy; Adipose selective disruption of SIRT1 impairs insulin sensitivity via modulation of macrophage infiltration and polarization in mice
Investigator(s):Hui X
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Hui X., Lam K.S.L. and Xu A., Adipose selective disruption of SIRT1 impairs insulin sensitivity via modulation of macrophage infiltration and polarization, Immunometabolism: From mechanism to therapeutic application. 2013.
Nie T., Hui X. and Xu A., Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function, FEBS Letter. 2012.
Xiao Y., Xu A., Hui X., Zhou P., Li X., Zhong H., Tang W., Huang G. and Zhou Z., Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes., Immunometabolism: from mechanisms to therapeutic applications. PLOS, 2013, 8: e66607.


Researcher : Hui YLE

Project Title:Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes
Investigator(s):Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013


List of Research Outputs

Chammas N.K., Shao E., Stacey C., Bell A., Wilson S., Ahmed K., Hui Y.L.E., Howe C. and Ramhamadany E., The DIAFOOT project: improved survival of diabetic foot patients begins with increased awareness, Diabetes UK Professional Annual Conference 2013.
Hui Y.L.E. and Qureshi A., Changing Trends in Patient Preference for Diabetic retinopathy screening, The 7th International Huaxia Congress of Endocrinology. 2012.
Hui Y.L.E. and Lam K.S.L., In search of the ideal basal insulin: Does the new-generation ultra-long-acting insulin, degludec, provide the answer?, Journal of Diabetes Investigation. 2013, 4: 39-41.
Hui Y.L.E., Xu A., Yang H.B. and Lam K.S.L., Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines, Journal of Diabetes Investigation. 2013, 4: 413-425.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Loong C.H.N., Woo Y.C., Leung E.L.Y., Yee S.W., Leung C.Y., Wong Y.F., Hui Y.L.E., Tan K.C.B. and Lam K.S.L., Consolidating service receivers: Nurse-led Clinic in the Management of Osteoporosis to Reinforce Lifestyle Modification, Increase Drug-adherence Rate and Osteoporosis Clinic Attendance Rate at Queen Mary Hospital, HA Convention 2013.
Wong K.K.C., Hui Y.L.E., Tan K.C.B., Chow W.S., Woo Y.C., Yeung C.Y., Leung C.Y., Yee A.S.W., Leung E.L.Y. and Lam K.S.L., Improving Glycaemic Control in the Management of Diabetes – the Role of Continuous Glucose Monitoring in Diabetes Nurse Clinic, HA Convention CGM. 2013.


Researcher : Hung IFN

List of Research Outputs

Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Shea Y.F., Chan F.H.W., Woo P.C.Y. and Chu L.W., Functional status of older nursing home residents can affect the efficacy of influenza vaccination. , Journal of Gerontology. 2013, 68: 324-330.
Cheng V.C.C., To K.K.W., Tse H., Hung I.F.N. and Yuen K.Y., Two Years After Pandemic Influenza A/2009/H1N1: What Have We Learned? , Clinical Microbiology Review. 2012, 25: 223-63.
Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
Hung I.F.N., Evolution of Pneumococcal Disease Management and Prevention, 17th Congress of the Asian Pacific Society of Respirology, 14-16 December 2012, Hong Kong. 2012.
Hung I.F.N., Evolution of Pneumococcal Disease Prevention, The Hong Kong Society for Infectious Diseases 17th Annual Scientific Meeting, 16 March 2013. 2013.
Hung I.F.N., Hyperimmune H-IVIG in the Treatment of Severe Influenza Pneumonia, Bioplasma World Asia 2012. 2012.
Hung I.F.N., Latest Advances in the Prevention of Herpes Zoster, Advances in Medicine 2013, June 29, 2013. 2013.
Hung I.F.N., Tantawichien T., Tsai Y.H., Patil S. and Zotomayor R., Regional Epidemiology of Invasive Pneumococcal Disease in Asian Adults: Epidemiology, Disease Burden, Serotype Distribution, and Antimicrobial Resistance Patterns and Prevention, International Journal of Infectious Diseases. 2013, 17(6): e364-e373.
Hung I.F.N., SARS and Influenza, Plenary Lecture of Inhalation Asia 2013. 2013.
Hung I.F.N., Specific Prevention Measures for Stomach Health Care - Helicobacter Pylori Eradication for Gastric Cancer Prevention, Asian Pacific Digestive Week 2012, 6 December 2012. 2012.
Hung I.F.N., Update on the Eradication of Helicobacter Pylori Infection, Annual Scientific Meeting of Macao Society of Gastroenterology & Hepatology, 28 July 2012. 2012.
Leung W.K., Hung I.F.N., Tong S.M. and Chu K.M., Characteristics and prognosis of patients diagnosed with gastric cancer after prior negative gastroscopy, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Lam Y.F., Tong S.M. and Hung I.F.N., Long term rebleeding in patients with obscure gastrointestinal bleeding after first deep enteroscopy, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Liu S.K., Tong S.M., Seto W.K.W. and Hung I.F.N., Occult hepatitis B infection in patients with inflammatory bowel disease, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Seto W.K.W., Chan K.H., Tong S.M. and Hung I.F.N., Prevalence Of Past Or Current Hepatitis B Infection And Factors For Non-vaccination In Chinese Patients With Inflammatory Bowel Diseases, The 1st Meeting of Asian Organization for Crohns’s and Colitis in Tokyo, Japan. 2013.
Leung W.K., Tong D.K.H., Leung S.Y., Chan F.S., Tong S.M., Hung I.F.N., Chu K.M. and Law S.Y.K., Treatment of gastric dysplasia and metaplasia by endoscopic radiofrequency ablation: A feasibility study, Digestive Disease Week, Orlando, USA. 2013.
Liu K.S.H., Seto W.K.W., Hung I.F.N. and Leung W.K., 10-day Sequential Versus 10-day Bismuth-Containing Quadruple Therapy As Empirical First-Line Treatment for Helicobacter pylori: An Open Label Randomized Crossover Trial, Digestive Disease Week, Orlando, USA. 2013.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Shea Y.F., Chan C.Y.J., Hung I.F.N. and Chan K.H., Hand, Foot and Mouth Disease in an Immunocompetent Adult due to Coxsackievirus A6, Hong Kong Medical Journal. 2013, 19(3): 262-4.
Shea Y.F., Chau K.M., Hung I.F.N. and Chu L.W., Strongyloidiasis in a nonagenarian who previously worked in conservancy services, Hong Kong Medical Journal . 2013, 19(1): 74-6.
Shea Y.F., Chiu J.W.Y., Mok M.Y., Hung I.F.N. and Yau T.C.C., Sunitinib-induced hyperammonaemia in a patient with pancreatic neuroendocrine tumour, Journal of Clinical Pharmacy and Therapeutics. 2013.
Srivastava V., YANG Z., Hung I.F.N., Xu J., Zheng B. and Zhang M., Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus, Journal of Virology . 2013, 87(10): 5831-40.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.
To K.K.W., Zhang J., Hung I.F.N. and Yuen K.Y., High Titer And Avidity Of Nonneutralizing Antibodies Against Influenza Vaccine Antigen Are Associated With Severe Influenza., Clin Vaccine Immunol . 2012, 19(7):1012-8.
To K.K.W., Wong S.C.Y., Xu T., Poon R.W.S., Mok K.Y., Chan J.F.W., Cheng V.C.C., Chan K.H., Hung I.F.N. and Yuen K.Y., Use of Nasopharyngeal Aspirate for Diagnosis of Pneumocystis Pneumonia, Journal of Clinical Microbiology. 2013, 51(5): 1570-4.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Ip MSM

Project Title:The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):Ip MSM
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:02/1997


Project Title:The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):Ip MSM, Peh WCG, Cooke MS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/1997


Project Title:Role of adiponectin in obstructive sleep apnoea
Investigator(s):Ip MSM, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):Ip MSM, Lam KSL, Song Y, Sham PC
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2005


List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Ip M.S.M., Associate Editor, Chest. 2013.
Ip M.S.M., Asthma management - Applying guidelines in clinical practice (Chairman Forum of the International Society or Organization), 11th Annual Conference of Chinese Association of Chest Physicians (CPAP) & 1st Across-strait 4 Region Symposium on Chinese Airway Diseases, Suzhou, China. 2012.
Ip M.S.M., Breathe well, sleep well and age well, Annual Scientific Meeting, Hong Kong Society of Sleep Medicine. 2012.
Ip M.S.M., Chairman, Scientific Symposium, 11th Annual Conference of Chinese Association of Chest Physicians (CACP), Suzhou, China. 2012.
Ip M.S.M., Chairperson, Symposium, 11th Annual Conference of Chinese Association of Chest Physicians (CPAP) & 1st Across-strait 4 Region Symposium on Chronic Airway Diseases, Suzhou, China. 2012.
Ip M.S.M., Chinese World Sleep Forum - OSA session (Forum Lecture, Panel Discussant), 7th Asian Sleep Research Society (ASRS), Taipei, Taiwan. 2012.
Ip M.S.M., Co-chairman - COPD: Bringing risk into perspective; Judge - Best Free Papers (Oral presentation); Co-chairman - Presidential Lectures, 17th Congress of the Asian Pacific Society of Respirology, Hong Kong. 2012.
Ip M.S.M., Co-chairman, Plenary Symposium 5: "Clinical Allergy: What's New?", 7th Hong Kong Allergy Convention, Hong Kong. 2012.
Ip M.S.M., Co-moderator : i) Respiratory Regulation in Sleep Apnea: from Basic Research to Clinical Practice ii) Sleep disordered breathing oral session, 7th Asian Sleep Research Society, Taipei, Taiwan. 2012.
Ip M.S.M., Comorbidities in severe asthma, Airway Vista 2013, Seoul, Korea. 2013.
Ip M.S.M., Facilitator, English Poster Discussion - "Lung Cancer (clinical)", 53rd Annual Meeting of the Japanese Respiratory Society, Tokyo, Japan. 2013.
Ip M.S.M., Honorary Advisor, The Hong Kong Respiratory Nursing College. 2012.
Ip M.S.M., Improving CPAP use in obstructive sleep apnea, 2012 International Forum of Sleep Disordered Breathing, Beijing Tongren Hospital, China. 2012.
Ip M.S.M., Issues on lung function testing in COPD, National Congress of Pulmonary Function Testing, Guangzhou, China . 2013.
Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2013.
Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2012.
Ip M.S.M., Member, Local Organizing Committee, 17th Congress of Asian Pacific Society of Respirology, Hong Kong. 2012.
Ip M.S.M., Member, American Thoracic Society Awards Committee. 2013.
Ip M.S.M., Member, American Thoracic Society/European Respiratory Society Global Lung Initiative on Multi-ethnic reference values for TLCO of lungs. 2013.
Ip M.S.M., Member, Joint Work Group on Medical Student Clinical Attachment, Hospital Authority, Hong Kong . 2013.
Ip M.S.M., Member, Research Council, Food and Health Bureau, HKSAR. 2012.
Ip M.S.M., Member, Scientific Committee on Lung Health, Hong Kong Tuberculosis, Chest and Heart Diseases Association. 2013.
Ip M.S.M., Member, Work Group on Clinical Management for Avian Infulenza A (H7N9) and Novel Coronavirus (NCoV), Hospital Authority, Hong Kong. 2013.
Ip M.S.M., Moderator, Poster Discussion Session, Airway Vista 2013; Seoul, Korea. 2013.
Ip M.S.M., OSA and atherosclerosis : Bedside and bench (Plenary Lecture), 7th Asian Sleep Research Society (ASRS), Taipei, Taiwan. 2012.
Ip M.S.M., Obstructive sleep apnea and glucose dysmetabolism - the ongoing challenge (Plenary Lecture), 8th International Symposium on Respiratory Diseases (ISRD) & ATS Forum, Shanghai, China. 2012.
Ip M.S.M., Overlap syndrome of OSA and COPD, Asian Pacific Symposium on Respiratory Diseases, Chengdu, China. 2013.
Ip M.S.M., Panel member for "National Clinical Research Center", 國家臨床醫學研究院中心綜合評審會, Beijing, China. 2013.
Ip M.S.M., President, Asian Pacific Society of Respirology. 2012.
Ip M.S.M., Research on SDB in the Asia Pacific, 8th International Symposium on Respiratory Diseases (ISRD) & ATS Forum, Shanghai, China. 2012.
Ip M.S.M., Reviewer, Grant Review Board, Research Council, Food and Health Bureau, HKSAR. 2012.
Ip M.S.M., Screening and early diagnosis of COPD, Airway Vista 2013, Seoul, Korea. 2013.
Ip M.S.M., The multi-faceted role of a clinical academic - Research and Teaching, Hong Kong Women Doctors Association, Leadership Series for Medical Women Year. 2013.
Irwin R.S., Augustyn N., French C.T., Rice J., Tedeschi V., Welch S.J. and Ip M.S.M., Spread the word about the journal in 2013: from citation manipulation to invalidation of patient-reported outcomes measures to renaming the Clara cell to new journal features, Chest. 2013, 143(1): 1-4.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., LI X., Ip M.S.M. and Mak J.C.W., Alterations of cigarette smoke-induced lipid metabolism in rat heart and lung, Am. J. Respir. Crit. Care Med.. 2013, 187: A4841.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, 17th Congress of the Asian Pacific Society of Respirology (APSR) . Respirology, 2012, 17 (Suppl. 2): 50.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, Respirology. 2012, 17 (Suppl. 2): 50.
LIANG Y., Ip M.S.M. and Mak J.C.W., Cigarette smoke-induced angiogenesis through AMPK activation in rat heart, J. Hong Kong College of Cardiol.. 2012, 20: 50.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Lau E.Y.Y., Ip M.S.M., Lee T.M.C., Yeung A.W.M. and Eskes G.A., Neuropsychological functioning of Hong Kong Chinese with obstructive sleep apnea. , SLEEP 2013 27th Annual Meeting of the Associated Professional Sleep Society, LLC (APSS). 2013.
Lui M.M., Lam C.L.D. and Ip M.S.M., Lui MM, Lam DC, Ip MS Significance of endothelial dysfunction in sleep-related breathing disorder , Respirology. 2013, 18(2): 39 - 46.
Mak J.C.W., Chu J.L., Yeung S.C., Chan M.M.W. and Ip M.S.M., Elevated plasma levels of growth differentiation factor (GDF)-15 in stable chronic obstructive pulmonary disease (COPD), Am. J. Respir. Crit. Care Med.. 2013, 187: A1526.
Quanjer P.H., Stanojevic S., Cole T.J., Baur X., Hall G.L., Culver B.H., Enright P.L., Hankinson J.L., Ip M.S.M., Zheng J. and Stocks J., Multi-ethnic reference values for spirometry for the 3-95 year ago range: The Global Lung 2012 Equations , European Respiratory Journal. 2012, 40(6): 1324-1343.
Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Tang S.C.W., Lam B., Lam J.C., Chan C.K., Chow C.C., Ho Y.W., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, Nephrology Dialysis Transplantation . 2012, 27: 2788-2794.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.
Wong K.Y.M., Lam C.L.D., Ip M.S.M. and Ho J.C.M., EBUS-TBNA gives adequate tissue information on cell type in lung cancer, Hong Kong Med.J.. 2013, 19 (Suppl. 1): 51.
Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.
Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase activity enhances MMP-7 dependent syndecan-1 shedding in the airway, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012 . 2012.
Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.
Yeung A.W.M., Lau E.Y.Y., Ip M.S.M., Lee T.M.C. and Eskes G.A., Neuropsychological functioning of nonapneic snoring Hong Kong Chinese. , SLEEP 2013 27th Annual Meeting of the Associated Professional Sleep Society, LLC (APSS). 2013.


Researcher : JIANG N

List of Research Outputs

JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin inhibits epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells through inhibition of MAPK phosphorylation, ISN World Congress of Nephrology 2013.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.


Researcher : Jin Y

Project Title:Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):Jin Y, Kwong YL, Tsao GSW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2002




Researcher : Keung WWY

Project Title:Promoting maturation of hESC-derived cardiomyocytes: the interplay between mitochondria, calcium and reactive oxygen species
Investigator(s):Keung WWY, Li RA
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2013




Researcher : Kong MCW

Project Title:Characterization of early-staged human embryonic stem cells cardiomyocytes (hESC-CMs): A potential cell source for successful cardiomyoplasty
Investigator(s):Kong MCW, Li RA
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:Generation of homogeneous ventricular cardiomyocytes (VCMs) from human pluripotent stem cells (hPSC)
Investigator(s):Kong MCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2012


List of Research Outputs

Li R.A., Kong M.C.W., Dong Sun D.S., Suk Han Cheng S.H.C., Youhua Tan Y.H.T. and Shuxun Chen S.X.C., Changes in the micromechanical properties of human embryonic stem cells during cardiac differentiation probed by optical tweezers, Journal of Biomechanics. In press.. 2012.


Researcher : Kopaniszen M

List of Research Outputs

Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.


Researcher : Kumana CR

List of Research Outputs

Chan L.S., Lau W.C.S., Kumana C.R. and Cheung B.M.Y., Utility of infrared thermography for screening febrile subjects, Hong Kong Medical Journal. 2013, 19: 109-115.
Cheung B.M.Y., Chan L.S., Lauder I.J. and Kumana C.R., Detection of body temperature with infrared thermography: accuracy in detection of fever, Hong Kong Medical Journal. 2012, 18 (4) Suppl 3: 31-34.
Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Intensive glucose lowering for diabetes: long-term impact on absolute mortality. , Presented at the 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.


Researcher : Kung AWC

Project Title:Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):Kung AWC, McGhee S
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:10/2009


List of Research Outputs

Cheung E., Bow H.Y.C., Loong C., Lee K.K., Ho A.Y.Y., Soong S.S., Chan Y.Y. and Kung A.W.C., A secular increase in BMD in Chinese women., Journal of Bone and Mineral Metabolism. 2013.
Ip T.P., Cheung S.K., Cheung T.C., Choi F., Chow E., Ho A., Kan A., Kung A.W.C., Lee K.K., Leung F.K.L., Leung J., Lo S., Sy C.T. and Wong Y.W., 2013 OSHK Guideline for Clinical Management of Postmenopausal Osteoporosis in Hong Kong. , Hong Kong Medical Journal. Vol 19 No2, Suppl 2.. 2013.
Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Kung MHW

List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.


Researcher : Kwan SC

List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.


Researcher : Kwan WMM

List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.


Researcher : Kwong YL

Project Title:Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):Kwong YL, Liang RHS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/1997


Project Title:Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):Kwong YL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Molecular basis of arsenic resistance in tumours
Investigator(s):Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):Kwong YL, Liang RHS, Lie AKW, Au WY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2004


Project Title:Provision of ibritumomab for the treatment of lymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):Kwong YL, Au WY, Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:05/2010


Project Title:Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2012


List of Research Outputs

Chan T., Mak H.K.F. and Kwong Y.L., Generalized lymph node immunoglobulin G amyloidoma. , Annals of Hematology . 2012, 91(9): 1503-1504.
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital, Intern Med J.. 2012, [Epub ahead of print].
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.
Cheng C.W., Chow K.M., Pang R.W.C., Fok E.W.S., Kwong Y.L. and Tse E.W.C., PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin., The American Journal of Pathology. 2013, 182(3): 765-775.
Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.
Hwang Y.Y., Sim P.Y.J., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment, Bone Marrow Transplantation. 2013, 48: 745-746.
Khong P.L., Kwong Y.L. and Huang B., Mid treatment FDG PET for early response assessment in NK/T cell lymphoma: a prospective study from a single center, 4th International Workshop on Interim-pet in Lymphoma, Menton, France, 4-5 October 2012.
Kwong Y.L., Kim W.S., Lim S.T., Kim S.J., Tang T., Tse E.W.C., Leung A.Y.H. and Chim J.C.S., SMILE for natural killer (NK)/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group, Blood. 2012, 120(15): 2973-2980.
Leung A.Y.H., Man C.H. and Kwong Y.L., FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia., Leukemia. 2013, 27(2): 260-8.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor., American Journal of Hematology. 2013, 88(6): 485-491.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S.C., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Relapses of acute leuekmia after allogeneic hematopoietic stem cell transplantation: second transplantation with reduced intensity conditioning from the original donor, Am J Hematol. 2013, in press.
Sim P.Y.J., Hwang Y.Y., Leung R.Y.Y., So J.C.C. and Kwong Y.L., Histiocytic sarcoma simulating immune thrombocytopenic purpura, Ann Hematol. 2013, 92(4): 555-6.
Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.
So J.C.C., Choi W.L. and Kwong Y.L., Pure red cell aplasia associated with CD20+ myeloma: complete remission with rituximab, Ann Hematol. 2013.
Tse E.W.C. and Kwong Y.L., How I treat NK/T-cell lymphomas, Blood. 2013, EPub.
Tse E.W.C. and Kwong Y.L., Practical management of natural killer/T-cell lymphoma, Current Opinion in Oncology. Lippincott Williams & Wilkins, Inc., 2012, 24(5): 480–486.
Tse E.W.C., Gill H., Loong F., Kim S.J., NG S.B., Tang T., Ko Y.H., Chng W.Y., Lim S.T., Kim W.S. and Kwong Y.L., Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group, American Journal of Hematology. 2012, 87(7): 663-8.
Wong K.Y., Yim R.L.H., Kwong Y.L., Leung C.Y., Hui P.K., Cheung F., Liang R.H.S., Jin D.Y. and Chim J.C.S., Epigenetic inactivation of the MIR129-2 in hematological malignancies, J Hematol Oncol. 2013, 6:16.
Yim R.L.H., Kwong Y.L., Wong K.Y. and Chim J.C.S., DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas, Frontiers in non-coding RNA. 2012, 2:233.


Researcher : LAM KYI

List of Research Outputs

WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.


Researcher : LAU KW

List of Research Outputs

LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.


Researcher : LEE PC

List of Research Outputs

Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.
Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Lam K.S.L., Hoo R.L.C., LEE P.C. and Xu A., A-FABP deficiency protects against diet induced steatohepatitis in mice, 95th Endocrine Society Annual Meeting and Expo. 2013.


Researcher : LI R

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.


Researcher : LI X

List of Research Outputs

LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., LI X., Ip M.S.M. and Mak J.C.W., Alterations of cigarette smoke-induced lipid metabolism in rat heart and lung, Am. J. Respir. Crit. Care Med.. 2013, 187: A4841.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.


Researcher : LIANG X

List of Research Outputs

LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : LIANG Y

List of Research Outputs

LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., LI X., Ip M.S.M. and Mak J.C.W., Alterations of cigarette smoke-induced lipid metabolism in rat heart and lung, Am. J. Respir. Crit. Care Med.. 2013, 187: A4841.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, 17th Congress of the Asian Pacific Society of Respirology (APSR) . Respirology, 2012, 17 (Suppl. 2): 50.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, Respirology. 2012, 17 (Suppl. 2): 50.
LIANG Y., Ip M.S.M. and Mak J.C.W., Cigarette smoke-induced angiogenesis through AMPK activation in rat heart, J. Hong Kong College of Cardiol.. 2012, 20: 50.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.


Researcher : LIM AI

List of Research Outputs

LIM A.I., Tang S.C.W., Chan Y.Y., Lai K.N. and Leung J.C.K., Chemokines Usage by Tubular Epithelial Cells in IgA Nephropathy: Role of TNF-α and Angiotensin II, J Am Soc Nephrol. 2012, 23: 854A.
LIM A.I., Tang S.C.W., Lai K.N. and Leung J.C.K., Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?, Journal of Cellular Physiology. 2013, 228: 917-924.
Leung J.C.K., LIM A.I., Chan Y.Y., Tang S.C.W. and Lai K.N., Dual Blockade of Angiotensin II and Prorenin Receptors Ameliorates Podocytic Apoptosis in IgA Nephropathy through Inhibition of the Notch Signaling Pathway, J Am Soc Nephrol. 2012, 23: 322A.


Researcher : LIN M

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.


Researcher : LIU L

List of Research Outputs

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.


Researcher : LUK TW

List of Research Outputs

WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.


Researcher : LUO Y

List of Research Outputs

LUO Y. and Lam C.L.D., Oncogenic driver mutations in lung cancere, Translational Respiratory Medicine. 2013, 1: 6.


Researcher : Lai AYK

Project Title:Long-term efficacy of an extended education programme on improving treatment adherence to continuous positive airway pressure in obstructive sleep apnea
Investigator(s):Lai AYK, Ip MSM, Lam CMJ, Fong DYT
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Mini Grants
Start Date:08/2011




Researcher : Lai CL

Project Title:A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2003


Project Title:Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:10/2003


Project Title:A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Idenix Pharmaceuticals, Inc - General Award
Start Date:01/2004


List of Research Outputs

Fung J.Y.Y., Yuen R.M.F., Lai C.L. and Ng I.O.L., Do statins reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis B?, Hepatobiliary Surgery and Nutrition. 2013, 2(1): 34-6.
Fung J.Y.Y., Lee C.K., Chan M., Seto W.K.W., Lai C.L. and Yuen R.M.F., High prevalence of non-alcoholic fatty liver disease in the Chinese – results from the Hong Kong liver health census. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands 24–28 April 2013, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S538.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Levels of HBV DNA and not HBsAg are associated with biochemical flares after HBeAg seroconversion, Hepatology International. 2012, 6: 52.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Chan A.C.Y., Sharr W.W., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B – long term outcome. (Oral presentation at the Transplant Plenary II Session of the 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 11, 2012), Hepatology. 2012, 56(S1): 196A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Yuen R.M.F., Chok K.S.H., Sharr W.W., Chan A.C., Cheung T.T., Seto W.K.W., Fan S.T., Lai C.L. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B, American Journal of Gastroenterology. 2013, 108(6): 942-8.
Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.
Fung J.Y.Y., Yuen R.M.F. and Lai C.L., The role of steatosis in HBsAg seroclearance for patients with chronic hepatitis B infection: fact or fiction?, Digestive Diseases and Sciences. 2013, 58(1): 20-2.
Gane E.J., Liaw Y.F., Wang Y., Lai C.L., Rasenack J., Zeuzem S., Chan H.L.Y., Ren H., Dong Y., Uddin A., Jung M.E., Bosset S. and Trylesinski A., eGFR improvement in chronic hepatitis b patients with telbivudine treatment is independent of antiviral activity, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58 (Suppl 1): S302.
Gish R.G., Chang T.T., Lai C.L., de Man R.A., Gadano A., Llamoso C. and Tang H., Quantitative hepatitis B surface antigen analysis in hepatitis B e antigen-positive, nucleoside-naive patients treated with entecavir, Antiviral Therapy. 2013.
Hon Y.Y.L., Fielding R., Lam W.W.T., Lai C.L., Yuen R.M.F., Ip D.K.M. and Tsang J.W.H., Validation of the Chinese version of the Revised-IPQ: Illness Perception Questionnaire-Revised for Cancer Predisposition (IPQ-CP) (abstract and poster presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking, 2012, 44-45.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.
Lai C.L., "Exploring the Virologic/Serologic Response", Gilead Satellite Symposium 'Where do we go from here? Exploring HBV treatment endpoints', 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2013), Singapore, June 8. 2013.
Lai C.L., "HBV Treatment: Past, Present and Future", State-of-the-Art Lecture, 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2013), Singapore, June 8. 2013.
Lai C.L., "Optimizing Recent HCV Treatments and Exploring Future’s Paradigm", Symposium Chairman, The 18th Hong Kong Medical Forum, Department of Medicine, The University of Hong Kong, Hong Kong, May 11. 2013.
Lai C.L., "Response Guided Therapy – Nucleoside", Clinical Track Session: Personalized Treatment of HBV, 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2013), Singapore, June 7. 2013.
Lai C.L., "Significance of HCV in Asia Pacific region", Co-chair the luncheon symposium, The Asian Pacific Digestive Week (APDW) 2012, Bangkok, Thailand between December 5-8. 2012.
Lai C.L., "The Hepatitis B Virus and I”, Special Honorary Fellow Award Lecture, The 32nd Annual General Meeting cum Scientific Meeting, The Hong Kong Society of Gastroenterology, March 14. 2013.
Lai C.L., "The present and future treatment of chronic hepatitis C", Keynote Lecture, Symposium 2012 State Key Laboratory for Liver Research (SKLLR), The University of Hong Kong, Hong Kong, September 22. 2012.
Lai C.L., Boceprevir Hong Kong case presentation, Hepatitis C Expert Input Forum 2012, Hong Kong, November 24. 2012.
Lai C.L., Debate: Treatment of Chronic Hepatitis B. Why I use of interferon? versus Why I use nucleos(t)ide analogues, Hepatology Society of the Philippines Annual Symposium, Manila, Philippines, January 25-26,. 2013.
Lai C.L., Discussion on Hong Kong Consensus Guidelines for the Treatment of Chronic Hepatitis C, The Third Hepatitis C Expert Input Forum, Hong Kong, April 13. 2013.
Lai C.L., Epidemiology of HBsAg-negative HBV carriers (Occult HBV), APASL 3rd Single Topic Conference (STC) on Hepatitis B Virus, Dhaka, Bangladesh between October 6-7. 2012.
Lai C.L., HCV in Hong Kong, Victrelis Launch Meeting, Hong Kong, May 14. 2013.
Lai C.L., Long Term Real World Data from Clinical Trials to Practice, Hepatology Society of the Philippines Annual Symposium, Manila, Philippines, January 25-26. 2013.
Lai C.L., Member of the APASL Eexecutive Council Meeting, Asia Pacific Association for the Study of the Liver (APASL) Executive Council Meeting, 14-15 July 2012. 2012.
Lai C.L., New Treatment of Chronic Hepatitis C, 澳門公立醫院醫生協會. 2013.
Lai C.L., Prevention of HCC by antiviral treatment, The First Central China International Forum on Liver Disease and Infection (CCIFLDI) hosted by Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China between September 21-23. 2012.
Lai C.L. and Yuen R.M.F., Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy., Hepatology. 2012, 57(1): 399-408.
Lai C.L. and Yuen R.M.F., Reduction of cirrhosis and hepatocellular carcinoma with antiviral therapy in chronic hepatitis B, Hepatology. 2013.
Lai C.L., Report from North Asia Policy Partnership Forum, Coalition to Eradicate Viral Hepatitis in Asia Pacific (CEVHAP) Symposium, APASL Liver Week, Singapore, June 8. 2013.
Lai C.L., Treatment of Hepatitis B in 2013, Seminar on Viral Hepatitis for Nurses and Allied Health Professionals 2013, Centre of Health Protection, Department of Health, Hong Kong, May 16. 2013.
Lai C.L., Viread-Real-Life experiences from Clinical Practices, Viread Scientific Symposium in Seoul, South Korea, February 26-27. 2013.
Lam T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., McGhee S. and So M.K., Cost-effectiveness Analysis of Anti-viral Treatment in Patients with Chronic Hepatitis B Infection in Hong Kong, Poster presented at the presented at the 2012 International Society for Quality of Life Research Annual Conference in Budapest on Oct 24-27, 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Fung J.Y.Y., Yuen R.M.F. and Lai C.L., Future prevention and treatment of chronic hepatitis B infection. , J Clin Gastroenterol. 2012, 46(9): 725-34.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B surfact antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 257.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Reply to Liao et al, Clin Infect Dis. 2013.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serologic and virologic outcomes of tenofovir in Asian chronic hepatitis B patients with prior nucleoside analogue exposure. (Poster presentation at the 63rd) Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 10, 2012, Hepatology. 2012, 56(S1): 415A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Seto W.K.W., Lam Y.F., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen levels during five years entecavir therapy in Asian chronic hepatitis B patients., The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S314.
Seto W.K.W., Hui A.J., Wong V.W.S., Wong G.L.H., Liu K., Lai C.L., Yuen R.M.F. and Chan H.L.Y., Serum hepatitis B surface antigen levels to guide the cessation of entecavir in hepatitis B e antigen-negative chronic hepatitis B: an interim analysis. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S315.
Seto W.K.W., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B monoinfection, Hepatology International. 2013, 7(2): 327-34.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.


Researcher : Lai CTM

List of Research Outputs

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.


Researcher : Lai KN

Project Title:The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):Lai KN, Leung JCK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
LIM A.I., Tang S.C.W., Chan Y.Y., Lai K.N. and Leung J.C.K., Chemokines Usage by Tubular Epithelial Cells in IgA Nephropathy: Role of TNF-α and Angiotensin II, J Am Soc Nephrol. 2012, 23: 854A.
LIM A.I., Tang S.C.W., Lai K.N. and Leung J.C.K., Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?, Journal of Cellular Physiology. 2013, 228: 917-924.
Leung J.C.K., LIM A.I., Chan Y.Y., Tang S.C.W. and Lai K.N., Dual Blockade of Angiotensin II and Prorenin Receptors Ameliorates Podocytic Apoptosis in IgA Nephropathy through Inhibition of the Notch Signaling Pathway, J Am Soc Nephrol. 2012, 23: 322A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
Tang S.C.W. and Lai K.N., Hepatitis C Virus-Associated Glomerulonephritis, Contributions to Nephrology. 2013, 181: 194-206.
Tang S.C.W. and Lai K.N., Hepatitis C virus-associated glomerulonephritis, In: Nan Chen, New Insights into Glomerulonephritis. Basel, Switzerland, S Karger AG, 2013, 194-206.
Tang S.C.W., Lam B., Lam J.C., Chan C.K., Chow C.C., Ho Y.W., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, Nephrology Dialysis Transplantation . 2012, 27: 2788-2794.
Yap Y.H.D. and Lai K.N., The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedside, Nephrology (Carlton). 2013, 18(4): 243-55.
Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Lai KWH

List of Research Outputs

Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.


Researcher : Lam B

List of Research Outputs

Tang S.C.W., Lam B., Lam J.C., Chan C.K., Chow C.C., Ho Y.W., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, Nephrology Dialysis Transplantation . 2012, 27: 2788-2794.


Researcher : Lam CL

Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


Project Title:Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):Lam CLD, Wan TSK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2012


List of Research Outputs



Researcher : Lam CLD

Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


Project Title:Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):Lam CLD, Wan TSK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2012


List of Research Outputs

LUO Y. and Lam C.L.D., Oncogenic driver mutations in lung cancere, Translational Respiratory Medicine. 2013, 1: 6.
Lam C.L.D., Clinical testing for Molecular targets for personalized treatment in lung cancer, Respirology. 2013, 18 (2): 233 - 7.
Lam C.L.D., Editorial Debate: Counterpoint: Should EGFR mutations be routinely tested for in patients with lung cancer?, CHEST. 2013, 143 (3): 600 - 2.
Lam C.L.D. and Heffner J.E., Translating Research into Practice: an epilogue, Respirology. 2013, 18 (2): 203 - 4.
Lui M.M., Lam C.L.D. and Ip M.S.M., Lui MM, Lam DC, Ip MS Significance of endothelial dysfunction in sleep-related breathing disorder , Respirology. 2013, 18(2): 39 - 46.
Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Wong K.Y.M., Lam C.L.D., Ip M.S.M. and Ho J.C.M., EBUS-TBNA gives adequate tissue information on cell type in lung cancer, Hong Kong Med.J.. 2013, 19 (Suppl. 1): 51.
Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.
Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Lam CLK

Project Title:Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):Lam CLK, Wong W
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:A Study on Health-related Quality of Life of patients with Colorectal Neoplasm and Cost-Effectiveness Analysis of Colorectal Cancer Screening in Hong Kong
Investigator(s):Lam CLK, Law WL, Poon TCJ, Wong CKH, McGhee S, Fong DYT
Department:Family Medicine and Primary Care
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2010


Project Title:Extended evaluation of quality of care of chronic disease management programmes and public-private partnership programmes of the Hospital Authority
Investigator(s):Lam CLK, Wong WCW, Chin WY, Chen JY, Fung SCC, Fong DYT, Yu YTE
Department:Family Medicine and Primary Care
Source(s) of Funding:Commissioned Study on Enhanced Primary Care
Start Date:07/2011


Project Title:19th Annual Conference of the International Society for Quality of Life Research (ISOQOL); Effectiveness of a Patient Empowerment Programme for Chinese Patients with Diabetes Mellitus
Investigator(s):Lam CLK
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012




Researcher : Lam CMJ

List of Research Outputs

Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).


Researcher : Lam KSL

Project Title:The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2006


Project Title:To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones
Investigator(s):Lam KSL, Xu A, Wang Y, Tso AWK
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2010


Project Title:Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
Investigator(s):Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:To Establish a Metabolic Study Centre in Hong Kong: Focusing on the Emerging Metabolic Hormones
Investigator(s):Lam KSL, Xu A, Wang Y, Cheung BMY, Wong CM
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:The Endocrine Society's 95th Annual Meeting & Expo; Adipocyte fatty acid binding protein deficiency protects against high fat high cholesterol diet-induced steatohepatitis in mice
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chen J., Xu A., Liu J., Lam K.S.L. and Wang Y., Adipose-derived Stromal Cells Derived from Adiponectin Deficient Mice Promote the Development of Metaplastic Mammary Tumors, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 67.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 promotes insulin secretion by up-regulating expression of exoytotic SNARE proteins via Akt dependent pathway in mice. , 7 th International Huaxia Congressof Endocrinology 2012.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 regulates insulin secretion in pancreatic beta cells. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults, Clin Nutr . 2012, S0261-5614(12)00281-6.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., High ferritin and low transferrin saturation are associated with pre-diabetes among adults, Journal of the Hong Kong College of Cardiology. Young Investigator Award Second Prize at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 51.
Cheung C.L., Cheung T.T., Lam K.S.L. and Cheung B.M.Y., Reduced serum beta-trace protein is associated with metabolic syndrome, Atherosclerosis. 2013, 227(2): 404-7.
Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality in people with diabetes, Eur J Endocrinol . 2013, 169(1): 1-7.
Cheung C.L., Tan K.C.B., Lam K.S.L. and Cheung B.M.Y., The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: A structural equation modeling approach., Journal of Clinical Endocrinology and Metabolism. 2013.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Henstridge D.C., Bruce C.R., Pang C.P., Lancaster G.I., Allen T.L., Estevez E., Gardner T., Weir J.M., Meikle P.J., Lam K.S.L., Fujii N., Goodyear L.J. and Febbraio M.A., Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice, Diabetologia . 2012, 55: 2769-78.
Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.
Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Hui X., Lam K.S.L. and Xu A., Adipose selective disruption of SIRT1 impairs insulin sensitivity via modulation of macrophage infiltration and polarization, Immunometabolism: From mechanism to therapeutic application. 2013.
Hui Y.L.E. and Lam K.S.L., In search of the ideal basal insulin: Does the new-generation ultra-long-acting insulin, degludec, provide the answer?, Journal of Diabetes Investigation. 2013, 4: 39-41.
Hui Y.L.E., Xu A., Yang H.B. and Lam K.S.L., Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines, Journal of Diabetes Investigation. 2013, 4: 413-425.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.
Lam K.S.L., Hoo R.L.C., LEE P.C. and Xu A., A-FABP deficiency protects against diet induced steatohepatitis in mice, 95th Endocrine Society Annual Meeting and Expo. 2013.
Lam K.S.L., Associate Editor, Journal of Diabetes Investigation. 2012.
Lam K.S.L., Associate Editor, Obesity Research & Clinical Practice. 2012.
Lam K.S.L., Editorial Board Member , Chinese Journal of Endocrinology and Metabolism. 中華內分泌代謝雜誌, 2012.
Lam K.S.L., Editorial Board Member, Clinical Endocrinology . 2012.
Lam K.S.L., Integrated Diabetes Care Centre, Hong Kong West & Queen Mary Hospital Outstanding Team Award. 2013.
Leng X.Y., Chen X.Y., Chook P., Xiong L., Lin W.H., Liu J.Y., Tomlinson B., Thomas G.N., Lam T.H., Lam K.S.L., Cheung B.M.Y. and Wong K.S., Association between metabolic syndrome and carotid atherosclerosis: A community-based study in Hong Kong, Metabolic Syndrome and Related Disorders. 2013, 11(2): 109-14.
Leng X.Y., Chen X.Y., Chook P., Xiong L., Lin W.H., Tomlinson B., Thomas G.N., Lam T.H., Lam K.S.L., Cheung B.M.Y. and Wong K.S., Correlation of Large Artery Intracranial Occlusive Disease With Carotid Intima-Media Thickness and Presence of Carotid Plaque, Stroke. 2013, 44(1): 68-72.
Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.
Li F.Y.L., Lam K.S.L. and Xu A., Therapeutic perspectives for adiponectin: An update, Curr Med Chem. 2012, 19(32): 5513-23.
Li F.Y.L., Baretella O., Tang E.H.C., Vanhoutte P.M., Lam K.S.L., Chung S.K. and Xu A., Tie-1dependent endothelial cell restricted over-expression of endothelin-1 paradoxically impairs vascular contractions response to serotonin, ET-12 meeting, London, 2012.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.
Lin Z., Tian H., Lam K.S.L., Lin S., Hoo R.L.C., Konishi M., Itoh N., Wang Y., Bomstein S.R., Xu A. and Li X., Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice, Cell Metabl . 2013, 17: 779-789.
Liu L., Liu J., Wong W.T., Tian X.Y., Lau C.W., Wang Y.X., Xu G., Pu Y., Zhu Z., Xu A., Lam K.S.L., Chen Z.Y., Ng C.F., Yao X. and Huang Y., Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension through GLP-1 Dependent Mechanism, Hypertension . 2012, 60(3): 833-41.
Loong C.H.N., Woo Y.C., Leung E.L.Y., Yee S.W., Leung C.Y., Wong Y.F., Hui Y.L.E., Tan K.C.B. and Lam K.S.L., Consolidating service receivers: Nurse-led Clinic in the Management of Osteoporosis to Reinforce Lifestyle Modification, Increase Drug-adherence Rate and Osteoporosis Clinic Attendance Rate at Queen Mary Hospital, HA Convention 2013.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and chronic liver diseases: an update, Adiponectin: Production, Regulation and Roles in Disease. Nova Science, 2012.
Wong H.K., Ong K.L., Leung Y.H., Lam T.H., Thomas G.N., Lam K.S.L. and Cheung B.M.Y., A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels, Journal of the Hong Kong College of Cardiology. Presented at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 56.
Wong K.K.C., Hui Y.L.E., Tan K.C.B., Chow W.S., Woo Y.C., Yeung C.Y., Leung C.Y., Yee A.S.W., Leung E.L.Y. and Lam K.S.L., Improving Glycaemic Control in the Management of Diabetes – the Role of Continuous Glucose Monitoring in Diabetes Nurse Clinic, HA Convention CGM. 2013.
Woo Y.C., Xu A., Wang Y. and Lam K.S.L., Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives, Clin Endocrinol (Oxf). 2012, 78: 489-496.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.Y., Li X. and Xu A., Toll-like receptor-4 mediated obesity-induced nonalcoholic steatohepatitis through activation on X-box binding protein-1 in mice, Gut. 2012, 61(7): 1058-67.
Yeung C.W., Mak C.M., Lam K.S.L. and Tam S., Hypoglycaemia due to autoimmune insulin syndrome in a 78-year-old Chinese man, Br J Biomed Sci. 2012, 69: 80-2.
Yeung C.Y., Lam K.S.L., Li L.S.W., Lam K.F., Tse H.F. and Siu D.C.W., Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia., Diabetes Care. 2012, 35(12): 2564-9.
Yuen M.M.A., Chow W.S., Fong H.Y. and Lam K.S.L., Skin autofluorescence is associated with microvascular complications in type 2 diabetes, The 48th Annual Meeting of the European Association for the Study of Diabetes, 29 Sept – 6 Oct 2012, Berlin, Germany. 2012.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Lam KYJ

List of Research Outputs

Lam K.Y.J., Wong Y., Shiu S.W.M., Betteridge D.J. and Tan K.C.B., Effect of insulin on the soluble receptor for advanced glycation end products (RAGE)., Diabetic Medicine. UK, Wiley, 2013, 30: 702-709.
Lam K.Y.J., Wang Y., Shiu S.W.M., Wong Y. and Tan K.C.B., Soluble receptor for advanced glycation end-products in Chinese Type 1 diabetic patients., The 9th International Diabetes Federation Western pacific Region Congress, Kyoto, Japan. 2012.
Loong H.N.C., Woo Y.C., Leung L.Y.E., Lam K.Y.J. and Tan K.C.B., Risk factors related to Chinese population with fracture., 3rd Asia-Pacific Osteoporosis Meeting, Kuala Lumpur, Malaysia.. 2012.


Researcher : Lam SK

Project Title:Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):Lam SK
Department:Medicine
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:07/2003


Project Title:Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):Lam SK, Wong BCY, Lin MC
Department:Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2004




Researcher : Lam SK

List of Research Outputs

Ho J.C.M. and Lam S.K., Suppression of Thymidylate Synthase by Arsenic Trioxide in Mesothelioma Cell Lines, Asian Pacific Society of Respirology. 2012.
Lam S.K. and Ng T.B., Purification and characterization of an antifungal peptide with potent antifungal activity but devoid of antiproliferative and HIV reverse transcriptase activities from Legumi secchi beans, Applied Biochemistry and Biotechnology. 2013, 169: 2165-74.
Li Y., Lam S.K., Mak J.C.W., Zheng C. and Ho J.C.M., Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer, Lung cancer. 2013.
Li Y., Lam S.K. and Ho J.C.M., The Role of Erlotinib-induced Autophagy in Non-Small Cell Lung Carcinoma, Asian Pacific Society of Respirology. 2012.
Zheng C., Lam S.K. and Ho J.C.M., Reactive Oxidative Species Take a Pivotal Role in Arsenic Trioxide induced Cell Death in Small Cell Lung Cancer Cells Via Regulation of Notch1 and HIF-1 a, Asian Pacific Society of Respirology. 2012.


Researcher : Lam TP

Project Title:Primary care physicians’ attitudes towards people with mental health problems in Hong Kong
Investigator(s):Lam TP, Lam KF, Lam WW
Department:Med - Family Medicine Unit
Source(s) of Funding:Small Project Funding
Start Date:12/2009


Project Title:What are the facilitators and obstacles to promote mental health help-seeking in primary care? – views of family physicians and psychiatrists
Investigator(s):Lam TP, Lo TL, Lam KF
Department:Med - Family Medicine Unit
Source(s) of Funding:Small Project Funding
Start Date:04/2011
Completion Date:09/2012


Project Title:What are the barriers and facilitators to undertaking continuing professional education among private non-specialist primary care practitioners in Hong Kong?
Investigator(s):Lam TP, Lam KF
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2012


Project Title:What are the enablers and barriers of help-seeking among the psychologically distressed in primary care setting? - Promoting mental well-being in Hong Kong
Investigator(s):Lam TP, Lam KF, Lam WW
Department:Family Medicine and Primary Care
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Asia Pacific Medical Education Conference; What Are The Learning Outcomes of A Short Postgraduate Training Course In Dermatology For Primary Care Doctors?
Investigator(s):Lam TP
Department:Family Medicine and Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:01/2013


Project Title:Early detection of dementia: the knowledge, attitudes and practice of primary care physicians.
Investigator(s):Lam TP, Leung CW, Lam KF, Wong KW, Chao DVK
Department:Family Medicine and Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Lam T.P., Co-Editor of Asia Pacific Family Medicine-the Official Journal of Wonca Asia Pacific. 2012.
Lam T.P., Co-Editor of Asia Pacific Family Medicine-the Official Journal of Wonca Asia Pacific. 2013.
Lam T.P., Member of the Editorial Board, Biomed Central Family Practice. 2012.
Lam T.P., Regional Editor of Journal of Evaluation and Clinical Practice. 2012.


Researcher : Lam WK

List of Research Outputs

Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.
Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Lan HY

Project Title:Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Sun Chieh Yeh Heart Foundation - General Award
Start Date:08/2006


Project Title:Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Baxter Health Care Ltd. - General Award
Start Date:05/2008


Project Title:Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2008


List of Research Outputs

Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Lan XR

Project Title:Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):Lan XR, Lan HY, Leung JCK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008




Researcher : Lau CP

Project Title:Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):Lau CP, Lee KLF
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:05/2000


Project Title:Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):Lau CP, Yu CM, Lan HY
Department:Medicine
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


List of Research Outputs

Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Lau C.P., Tse H.F., Siu D.C.W. and Gbadebo D., Atrial electrical and structural remodeling: implications for racial differences in atrial fibrillation., In: Eric N. Prystowsky, Journal of Cardiovascular Electrophysiology. Wiley Periodicals, Inc., 2012, 23 Suppl 1: S36-40.
Lau C.P., Gbadebo D.T., Connolly S.J., Van G.E.L.D.E.R. .I.C., Capucci A., Gold M.R., Israel C.W., Morillo C.A., Siu D.C.W., Abe H., Carlson M. and Tse H.F., Ethnic difference in atrial fibrillation identified using implanted cardiac devices., J Cardiovasc Electrophysiology. 2013, 24: 381-387.
Lau C.P., Gbadebo D.T., Connolly S.J., Van Gelder I.C., Capucci A., Gold M.R., Israel C.W., Morillo C.A., Siu D.C.W., Abe H., Carlson M., Hohnloser S.H. and Healey J.S., Ethnic differences in atrial fibrillation identified using implanted cardiac devices., In: Eric N. Prystowsky, Journal of Cardiovascular Electrophysiology. 2013 Wiley Periodicals, Inc., 2013, 24: 381-387.
Lau C.P. and Tse H.F., Linear ablation for atrial fibrillation guided by acoustic imaging: "How does it sound?" , Heart Rhythm. . 2012, 9: 1863-1864.
Lau C.P., Siu D.C.W. and Tse H.F., Pacing inducibility for atrial fibrillation: A test tested?, J Cardiovasc Electrophysiol. . 2013.
Lau C.P., Tachapong N., Wang C.C., Wang J.F., Abe H., Kong C.W., Liew R., Shin D.G., Padeletti L., Kim Y.H., Omar R., Jirarojanakorn K., Kim Y.M., Chen M.C., Sriratanasathavorn C., Munawar M., Kam R., Chen J.Y., Cho Y.K., Li Y.G., Wu S.L., Bailleul C. and Tse H.F., Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study., Circulation. 2012, 126: 2789.
Lau C.P. and Zhang S., Remote monitoring of cardiac implantable devices in the Asia-Pacific., In: A. John Camm, The European Journal of Pacing, Arrhythmias and Cardiac Electrophysiology of the European Heart Rhythm Association of the European Society of Cardiology. . 2013, 15: i65-i68.
Lau C.P., Siu D.C.W. and Tse H.F., The future of implications for cardiac rhythm management, Circulation. 2013, 128: 687-93.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Li G.R., Lau C.P., Qin G.W. and Wang H.B., Use of acacetin and related compounds as potassium channel inhibitors, US Patent US 8461198B2. Washington, DC: US Patent and Trademark Office (USPTO). Washington, DC, US Patent and Trademark Office, 2013, US 8461198B2.
Li G.R., Lau C.P., Qin G.W. and Wang H.B., 黃酮化合物作為鉀通道抑制劑的用途, 中華人民共和國國家知識產權局, 中華人民共和國國家知識產權局, 2012, CN 101273984B.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Lau G

Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007


List of Research Outputs

LI J., Lau G., Chen L., Yuan Y.F., Huang J., Luk J.M.C., Xie D. and Guan X., Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression, PLoS One. 2012, 7(9): e46264.


Researcher : Lau GKK

Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007


List of Research Outputs

Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Best Abstract in Clinical Medicine: Prognostic Implications of Surrogate Markers of Atherosclerosis in Low to Intermediate Risk Patients with Type 2 Diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Lau GKK

Project Title:Cytochrome P450 polymorphisms and clopidogrel resistance in Chinese with ischaemic stroke
Investigator(s):Lau GKK, Chan KH, Siu DCW, Tse HF, Cheung BMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:12/2011


List of Research Outputs

Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Best Abstract in Clinical Medicine: Prognostic Implications of Surrogate Markers of Atherosclerosis in Low to Intermediate Risk Patients with Type 2 Diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Lau KS

List of Research Outputs

Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Lau KW

List of Research Outputs

LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.


Researcher : Lau WCS

Project Title:Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:01/1993


Project Title:Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):Lau WCS, Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):Lau WCS, Chan YTE, Cheung BMY
Department:Medicine
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2005


Project Title:Characterisation of the features and functional changes of bone marrow dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2010
Completion Date:09/2012


Project Title:Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:The role of plasmacytoid dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS, Chan VSF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Chan L.S., Lau W.C.S., Kumana C.R. and Cheung B.M.Y., Utility of infrared thermography for screening febrile subjects, Hong Kong Medical Journal. 2013, 19: 109-115.
Chan V.S.F., Tsang H.L., Tam C.Y., Lu L. and Lau W.C.S., B-cell-targeted therapies in systemic lupus erythematosus., Cellular & Molecular Immunology. 2013, 10(2): 133-42.
Fagerholm S.C., MacPherson M., James M.J., Sevier-Guy C. and Lau W.C.S., The CD11b-integrin (ITGAM) and systemic lupus erythematosus, Lupus. 2013, 22(7): 657-663.
GAO Y., Li L.S.W., Chau L.H., Lo Y., Lau W.C.S. and Mok T.M.Y., Assessment of autonomic function in patients with a history of neuropsychiatric lupus, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.
Lau W.C.S., Contemporary approach in the management of the common inflammatory arthritides, BMA (HK) Therapeutics Course – Chronic Diseases, Hong Kong. 2013.
Lau W.C.S., Credentialing: Perspectives from the Academy, Hospital Authority Convention, Hong Kong. 2013.
Lau W.C.S., Differentiating flare from infection, Asian Lupus Summit, Manila, Philippines. 2012.
Lau W.C.S., Impact of SLE in Asia Pacific – effect of Asian and indigenous ethnicity, Asia-Pacific Lupus Experts Awareness Programme (LEAP) meeting, Melbourne, Australia. 2013.
Lau W.C.S., Lupus in Asia: State of affairs and future directions, Asian Lupus Summit, Manila, Philippines. 2012.
Lau W.C.S., New insights into signal transduction: A promising target for treatment, Annual Meeting of Thai Rheumatism Association (TRA), Huahin, Thailand. 2013.
Lau W.C.S., Predictors of maternal-fetal outcome, Asian Lupus Summit, Manila, Philippines. 2012.
Lau W.C.S., Reducing Cardiovascular Risk in SLE Patients, The 15th Congress of Asia Pacific League of Associations for Rheumatology, Advancing Rheumatology in the Asian Pacific Region, Dead Sea, Jordan, September 2012. 2012.
Lau W.C.S., Systemic Lupus Erythematosus in Asia: State of the Art, Annual Meeting of Thai Rheumatism Association (TRA), Huahin, Thailand. 2013.
Lau W.C.S., The ACR guidelines on the management of lupus nephritis, Shenzhen Continuing Education Program: The First-Shenzhen-Hong Kong Cooperation Rheumatology Symposium. Shenzhen, China. 2013.
Lau W.C.S., Update on the Immunopathogenesis of SLE, The 15th Congress of Asia Pacific League of Associations for Rheumatology, Advancing Rheumatology in the Asian Pacific Region, Dead Sea, Jordan, September 2012. 2012.
Li P.H., Wong W.H.S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Tong K.L., Tse N.K.C., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chong C.Y., Wong R.W.S., Mok T.M.Y., Ying S.K.Y., Fung S.K.S., Lai W.M., Yang W. and Lau Y.L., Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese, Rheumatology. Oxford, 2013, 52(2): 337-345.
Mak A., Isenberg D.A. and Lau W.C.S., Global trends, potential mechanisms and early detection of organ damage in SLE, Nature Reviews Rheumatology. 2013, 9(5): 301-10.
Sharma N., Lau W.C.S., Morris G., Doherty I. and Harbutt D.D., Poster Presentation: Evaluation of the Flipped Classroom at the Li Ka Shing Faculty of Medicine, 7th Conference of the Asian Medical Educational Association (AMEA), Evaluation in Medical Education Present and Future, Health Sciences. 2013.
Tsang H.L., Chung H.Y., Mok T.M.Y. and Lau W.C.S., Kinase Inhibitors for the Treatment of Rheumatoid Arthritis, Hong Kong Bulletin on Rheumatic Diseases. 2012, 12: 43-49.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.
Yang W., Tang H., Zhang Y., Tang X., ZHANG J., Sun L., Yang J., Cui Y., Zhang L., Hirankarn N., Cheng H., Pan H.F., Gao J., Lee T.L., Sheng Y., Lau W.C.S., Li Y., Chan T.M., Yin X., Ying D., Lu Q., Leung A.M.H., Zuo X., Chen X., Tong K.L., Zhou F., Diao Q., Tse N.K.C., Xie H., Mok C.C., Hao F., Wong S.N., Shi B., Lee K.W., Hui Y., Ho M.H.K., Liang B., Lee P.P.W., Cui H., Guo Q., Chung B.H.Y., Pu X., Liu Q., Zhang X., Zhang C., Chong C.Y., Fang H., Wong R.W.S., Sun Y., Mok T.M.Y., Li X.P., Avihingsanon Y., Zhi Z., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Gao F., Shotelersuk V., Kang X., Ying S.K.Y., Zhang L., Wong W.H.S., Zhu D., Fung S.K.S., Zeng F., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Shen N., Tam P.K.H., Sham P.C., Ye D.Q., Yang S., Zhang X. and Lau Y.L., Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians, The American Journal of Human Genetics. 2013, 92: 41-51.
Zhang J., Zhang Y., Zhang L., Yang J., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Lau Y.L. and Yang W., Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients, Annals of Human Genetics. 2013, 77(4): 344-350.


Researcher : Lau YF

List of Research Outputs

Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Lee KK

List of Research Outputs

Cheung E., Bow H.Y.C., Loong C., Lee K.K., Ho A.Y.Y., Soong S.S., Chan Y.Y. and Kung A.W.C., A secular increase in BMD in Chinese women., Journal of Bone and Mineral Metabolism. 2013.


Researcher : Lee PC

List of Research Outputs

Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.
Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Lam K.S.L., Hoo R.L.C., LEE P.C. and Xu A., A-FABP deficiency protects against diet induced steatohepatitis in mice, 95th Endocrine Society Annual Meeting and Expo. 2013.


Researcher : Lee SWL

List of Research Outputs

Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.


Researcher : Lee YK

List of Research Outputs

Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.


Researcher : Leung AYH

Project Title:Provision of free alemtuzumab (anti-CD52) to patients with chronic lymphocytic leukemia refractory to conventional chemotherapy
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2007


Project Title:Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):Leung AYH, Kwong YL, Tang SCW
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2009


Project Title:Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2010


Project Title:Is aldehyde dehydrogenase a negative regulator of primitive hematopoiesis during embryonic development?
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:Study of Microglia and Acute Myeloid Leukemia in Zebrafish
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:05/2010


Project Title:A novel role of methionine aminopeptidase 2 (MetAP-2) in the regulation of hematopoietic stem cell during definitive hematopoiesis
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2010


Project Title:Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Is sox7 a tumour suppressor in acute myeloid leukemia?
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Cheung W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital, Intern Med J.. 2012, [Epub ahead of print].
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.
Chow C.H., Cheung A.M.S., Li R.A., Chan C.W.Y., So E.C.W. and Leung A.Y.H., The use of human induced pluripotent stem cells (hiPSC) for modeling blood disorders, Drug Discovery Today: Disease Models. 2012.
Hwang Y.Y., Sim P.Y.J., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment, Bone Marrow Transplantation. 2013, 48: 745-746.
Kwong Y.L., Kim W.S., Lim S.T., Kim S.J., Tang T., Tse E.W.C., Leung A.Y.H. and Chim J.C.S., SMILE for natural killer (NK)/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group, Blood. 2012, 120(15): 2973-2980.
Leung A.Y.H., Man C.H. and Kwong Y.L., FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia., Leukemia. 2013, 27(2): 260-8.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor., American Journal of Hematology. 2013, 88(6): 485-491.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S.C., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Relapses of acute leuekmia after allogeneic hematopoietic stem cell transplantation: second transplantation with reduced intensity conditioning from the original donor, Am J Hematol. 2013, in press.
Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.


Researcher : Leung JCK

Project Title:Renin-angiotensin system within the podocytes in IgA nephropathy
Investigator(s):Leung JCK, Lai KN
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications
Investigator(s):Leung JCK
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
LIM A.I., Tang S.C.W., Chan Y.Y., Lai K.N. and Leung J.C.K., Chemokines Usage by Tubular Epithelial Cells in IgA Nephropathy: Role of TNF-α and Angiotensin II, J Am Soc Nephrol. 2012, 23: 854A.
LIM A.I., Tang S.C.W., Lai K.N. and Leung J.C.K., Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?, Journal of Cellular Physiology. 2013, 228: 917-924.
Leung J.C.K., LIM A.I., Chan Y.Y., Tang S.C.W. and Lai K.N., Dual Blockade of Angiotensin II and Prorenin Receptors Ameliorates Podocytic Apoptosis in IgA Nephropathy through Inhibition of the Notch Signaling Pathway, J Am Soc Nephrol. 2012, 23: 322A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Leung RCY

List of Research Outputs

Leung R.C.Y., Lang B.H.H., Wong H.Y.H., Chiu J.W.Y., Wan K.Y., Shek T.W.H., Woo Y.C., Lo C.Y. and Yau T.C.C., Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy, Anti-Cancer Agents in Medicinal Chemistry. 2013, 13(3): 382-388.


Researcher : Leung WK

Project Title:Molecular characterization of bacterial microbiota in the stomach of patients with H. pylori infection
Investigator(s):Leung WK, Woo PCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:09/2011


Project Title:A prospective randomized trial to compare the safety and immunogenicity of intradermal and intramuscular influenza vaccines in patients with inflammatory bowel disease in Hong Kong
Investigator(s):Leung WK, Hung IFN, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


List of Research Outputs

Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Lam Y.F., Seto W.K.W., Tong S.M. and Leung W.K., Findings On Surveillance Colonoscopy In Patients With Serrated Lesions Of The Colon, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Acute Non-variceal Upper GI Bleeding, Annual Meeting of the Hong Kong College of Physicians. 2012.
Leung W.K., Advances in GI Endoscopy, Hong Kong Surgical Forum. 2013.
Leung W.K., Ho S.S.M., Suen B.Y., Lai L.H., Yu S., Ng E.K.W., Ng S.S.M., Chiu P.W.Y., Sung J.J.Y., Chan F.K.L. and Lau J.Y.W., Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up, Am J Gastroenterol. 2012, 107(9): 1370-6.
Leung W.K., Hung I.F.N., Tong S.M. and Chu K.M., Characteristics and prognosis of patients diagnosed with gastric cancer after prior negative gastroscopy, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Current imitation and advances for GERD treatment, 8th International Symposium on Healthy Aging organized by Research Centre of heart, Brain, Hormone and Healthy Aging, HKU. 2013.
Leung W.K., Tan V.P.Y. and Lui P.C., Detection rates of proximal or large serrated polyps in Chinese patients undergoing screening colonoscopy, J Dig Dis. 2012, 13(9): 466-71.
Leung W.K., Diagnostic and therapeutic procedures of obscure GIB, Inaugural Conference of Macao Society of Gastroenterology and Hepatology, Macau SAR. 2012.
Leung W.K., Editorial Board Member, Helicobacter . 2013.
Leung W.K., Editorial Board Member, Hepatogastroenterology . 2013.
Leung W.K., Fertility, pregnancy and breast-feeding in patients with inflammatory bowel disease, 7th Wuhan Inflammatory Bowel Disease Summit, Wuhan, China. 2012.
Leung W.K., HK GERD epidemiology, Diagnosis and Therapy, Forum of World Chinese Digestion Summit – GI, Kaohsiung, Taiwan. 2013.
Leung W.K., How to prevent post-sphincterotomy bleeding?, 5th Eastern Biliary-Pancreatic Endoscopy Forum”, Shanghai, China. 2013.
Leung W.K., Infections and IBD, Hong Kong IBD Society Annual Scientific Meeting. 2013.
Leung W.K., Liu S.H., Lam Y.F., Tong S.M. and Hung I.F.N., Long term rebleeding in patients with obscure gastrointestinal bleeding after first deep enteroscopy, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Liu S.K., Tong S.M., Seto W.K.W. and Hung I.F.N., Occult hepatitis B infection in patients with inflammatory bowel disease, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Seto W.K.W., Chan K.H., Tong S.M. and Hung I.F.N., Prevalence Of Past Or Current Hepatitis B Infection And Factors For Non-vaccination In Chinese Patients With Inflammatory Bowel Diseases, The 1st Meeting of Asian Organization for Crohns’s and Colitis in Tokyo, Japan. 2013.
Leung W.K., Role of endoscopy: Capsule vs balloon enteroscopy, The 6th Meeting of the Society of Gastrointestinal Intervention, Seoul, Korea. 2012.
Leung W.K., Screening for colorectal cancer: What are the latest evidences?, Macau Physician Society Meeting. 2012.
Leung W.K., Tong D.K.H., Leung S.Y., Chan F.S., Tong S.M., Hung I.F.N., Chu K.M. and Law S.Y.K., Treatment of gastric dysplasia and metaplasia by endoscopic radiofrequency ablation: A feasibility study, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Update on use of biologics for inflammatory bowel disease in Hong Kong, Multi-specialty Medial Mega Conference (M3C 3.0) organized by the Private Medical Specialists of Hong Kong. 2013.
Leung W.K., Ng S.C., Chow D.K.L., Lao W.C., Leung V.K.S., Li M.K.K., Hui Y.T., Ng S.S.M., Hui A.J., Lai S.T., Lam J.T.W., Poon T.C.J., Chan A.O.O., Yuen H. and Wu J.C.Y., Use of biologics for inflammatory bowel disease in Hong Kong: consensus statement, Hong Kong Med J. Hong Kong, 2013, 19(1): 61-8.
Liu K.S.H., Seto W.K.W., Hung I.F.N. and Leung W.K., 10-day Sequential Versus 10-day Bismuth-Containing Quadruple Therapy As Empirical First-Line Treatment for Helicobacter pylori: An Open Label Randomized Crossover Trial, Digestive Disease Week, Orlando, USA. 2013.
Ng S.C., Lau J.Y.W., Chan F.K.L., Suen B.Y., Leung W.K., Tse Y.K., Ng S.S.M., Lee J.F.Y., To K.F., Wu J.C.Y. and Sung J.J.Y., Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer, Gastroenterology. 2013, 144(3): 544-50.


Researcher : Leung YH

List of Research Outputs

WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wong H.K., Ong K.L., Leung Y.H., Lam T.H., Thomas G.N., Lam K.S.L. and Cheung B.M.Y., A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels, Journal of the Hong Kong College of Cardiology. Presented at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 56.


Researcher : Li C

List of Research Outputs

Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.


Researcher : Li FYL

List of Research Outputs

Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.
Li F.Y.L., Lam K.S.L. and Xu A., Therapeutic perspectives for adiponectin: An update, Curr Med Chem. 2012, 19(32): 5513-23.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.Y., Li X. and Xu A., Toll-like receptor-4 mediated obesity-induced nonalcoholic steatohepatitis through activation on X-box binding protein-1 in mice, Gut. 2012, 61(7): 1058-67.


Researcher : Li G

Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Demonstration of TRPM channels in human cardiac atrial myocytes
Investigator(s):Li GR, Li X
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012
Completion Date:03/2013


Project Title:Roles of Functional Ion Channels in Migration and Proliferation of Human Cardiac c-Kit+ Cells
Investigator(s):Li GR, Cheng LC, Li X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:American Heart Association Scientific Sessions 2012; Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2012


List of Research Outputs



Researcher : Li GR

Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Demonstration of TRPM channels in human cardiac atrial myocytes
Investigator(s):Li GR, Li X
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012
Completion Date:03/2013


Project Title:Roles of Functional Ion Channels in Migration and Proliferation of Human Cardiac c-Kit+ Cells
Investigator(s):Li GR, Cheng LC, Li X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:American Heart Association Scientific Sessions 2012; Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells
Investigator(s):Li GR
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2012


List of Research Outputs

Che H. and Li G.R., Effects of Functional Transient Receptor Potential Channels on Adipogenesis and Proliferation in Human Preadipocytes, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 163.
Che H. and Li G.R., Effects of Functional Transient Receptor Potential Channels on Proliferation and Migration in Human Cardiac C-Kit+ Cells, 18th Medical Research Conference, Department of Medicine, HKU. 2013. 19(1): 23.
Li G.R., Chen K. and Sun H., Distinctive density,biophysical properties, and pharmacology of voltage-gated sodium current in atrial and ventricular myocytes. Heart Rhythm 34th Annual Scientific Sessions. May 8-11, 2013. Denver, Colorado, USA, Heart Rhythm . 2013, 10(5S): S322.
Li G.R., Myocardial ionic channel targets of anti-AF and their pharmacologic studies. 15th South China International Congress of Cardiology. 11-15 April 2013. GuangZhou, China., 2013.
Li G.R., SKCa channels are a novel target for anti-arrhythmic study. 15th South China International Congress of Cardiology. 11-15 April 2013. GuangZhou, China., South China Journal of Cardiovascular Diseases. Supplement 2013. 2013, 19: 42.
Li G.R., Study on antiarrhythmic pharmacology, Pharmacological Conference-June 28-30, 2013, Hubei Pharmacological Society, Enshi, Hubei, China . 2013.
Li G.R., Lau C.P., Qin G.W. and Wang H.B., Use of acacetin and related compounds as potassium channel inhibitors, US Patent US 8461198B2. Washington, DC: US Patent and Trademark Office (USPTO). Washington, DC, US Patent and Trademark Office, 2013, US 8461198B2.
Li G.R., Lau C.P., Qin G.W. and Wang H.B., 黃酮化合物作為鉀通道抑制劑的用途, 中華人民共和國國家知識產權局, 中華人民共和國國家知識產權局, 2012, CN 101273984B.
Liu Y., Xu X.H., Liu Z., Du X.L., Chen K.H., Xin X., Jin Z.D., Shen J.Z., Hu Y., Li G.R. and Jin M.W., Effects of the natural flavone trimethylapigenin on cardiac potassium currents. , Biochem Pharmacol. 2012, 84(4): 498-506.
Wang L.P., Wang Y., Zhao L.M., Li G.R. and Deng X.L., Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. , Biochem Pharmacol. 2013, 85(10): 1486-94.
Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Wu W., Sun H., Deng X.L. and Li G.R., EGFR Tyrosine kinase regulates small conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK 293 cells, Biochem J. 2013, 452(1): 121-129.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.
Zhao L.M., Zhang W., Wang L.P., Li G.R. and Deng X.L., Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of K(Ca)3.1 channels, Pflugers Arch. 2012, 464(6): 613-21.
Zhao L.M., Su X.L., Wang Y., Li G.R. and Deng X.L., K(Ca)3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells. , Lab Invest. 2012, 93(2): 159-67.


Researcher : Li LSW

List of Research Outputs

Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Yeung C.Y., Lam K.S.L., Li L.S.W., Lam K.F., Tse H.F. and Siu D.C.W., Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia., Diabetes Care. 2012, 35(12): 2564-9.


Researcher : Li RA

Project Title:Non-cell autonomous directed maturation of developmentally arrested hESC/iPSC-derived cardiomyocytes
Investigator(s):Li RA
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011
Completion Date:12/2012


Project Title:Cell-based Heart Regeneration
Investigator(s):Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:09/2011


List of Research Outputs

Chow C.H., Cheung A.M.S., Li R.A., Chan C.W.Y., So E.C.W. and Leung A.Y.H., The use of human induced pluripotent stem cells (hiPSC) for modeling blood disorders, Drug Discovery Today: Disease Models. 2012.
Li R.A., Kong M.C.W., Dong Sun D.S., Suk Han Cheng S.H.C., Youhua Tan Y.H.T. and Shuxun Chen S.X.C., Changes in the micromechanical properties of human embryonic stem cells during cardiac differentiation probed by optical tweezers, Journal of Biomechanics. In press.. 2012.
Li R.A., Irene Turnbull I.T., Kevin D. Costa K.C. and Deborah K. Lieu D.L., Engineered human pluripotent stem cell-derived cardiomyocyte tissues for mechanobiological studies of cardiac disease models. , Drug Discov Today Dis Models. In press. 2012.
Li R.A., Engineering human heart cells and tissues. U of Toronto, Distinguished Visiting Professor Series. 2012.
Li R.A., Gene- and Cell-based Bio-artificial Pacemaker: What Basic and TranslationalLessons Have We Learned, Gene Therapy. 19(6):588-95. PMID: 22673497. 2012.
Li R.A., Bu L. and Lui O.L.K., Human pluripotent stem cell-derived cardiovascular progenitors for heartregeneration, Drug Discovery Today: Disease Model. In press.. 2012.
Li R.A., Ji-Dong Fu J.D.F., Siu D.C.W., Jennifer C. Moore J.M., Deborah K. Lieu D.L., Valeriy Timofeyez V.T., Nipavan Chiamvimonvat N.C., Tse H.F. and Gordon Keller G.K., Identification of a common determinant for the immature properties of derived human cardiomyocytes enables mechanism-based driven maturation, Circulation. . 2012.
Li R.A., Padmini Sirish P.S., Javier E. López J.L., Ning Li N.L., Andrew Wong A.W., Valeriy Timofeyev V.T., J. Nilas Young J.N.Y., Maryam Majdi M.M., and Huei-sheng Vincent Chen H.S.V.C., Nipavan Chiamvimonvat N.C., MicroRNA Profiling Predicts a Variance in The Proliferative Potential of Cardiac Progenitor Cells Derived From Neonatal and Adult Murine Hearts. , J Mol Cell Cardiol. 52(1):264-72. PMID: 22062954. 2012.
Li R.A., Role of TRPM2 in H(2)O(2)-Induced Cell Apoptosis in Endothelial Cells, PLoS One. 8(8):e43186. Epub 2012 Aug 20. PMID:22916222. 2012.
Li R.A., Ming Zhan M.Z., Bin Yan B.Y., Daniel R. Riordon D.R., Yelena Tarasova Y.T., Sarah Bruweleit S.B., Kirill Tarasov K.T., Robert P. Wersto R.W. and Kenneth R. Boheler K.B., The B-MYB Transcriptional Network Governs Cell Cycle Progression and Fate Decisions to Sustain the Identity and Self-Renewal Properties of Pluripotent Stem Cells, PloS One. In press . 2012.
Li R.A., The Use of Induced Pluripotent Stem Cell for Disease Modeling: What are the Promises and Hurdles?, Drug Discov Today Dis Models. In press.. 2012.


Researcher : Li TW

List of Research Outputs

Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Best Abstract in Clinical Medicine (Oral), 18th Medical Research Conference, Department of Medicine, HKU; 2013. 2012, 30(45): 6427-35.
Hung I.F.N., Levin Y., To K.K.W., Chan K.H., Zhang J., Li T.W., Li P.Y., Xu T., Wong T.Y. and Yuen K.Y., Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain, Vaccine. 2012, 30(45): 6427-35.
To K.K.W., Hung I.F.N., Xu T., Poon R.W.S., Ip W.C.T., Li T.W., Li P.Y., Lau S.K.P., Yam W.C., Chan K.H. and Yuen K.Y., Clinical Significance of Pneumocystis Jiroveci in Patients with Active Tuberculosis, Diagnostic Microbiology and Infectious Disease. 2013, 75(3): 260-265.


Researcher : Li X

List of Research Outputs

LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., LI X., Ip M.S.M. and Mak J.C.W., Alterations of cigarette smoke-induced lipid metabolism in rat heart and lung, Am. J. Respir. Crit. Care Med.. 2013, 187: A4841.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.


Researcher : Li Y

List of Research Outputs

Li Y., Lam S.K., Mak J.C.W., Zheng C. and Ho J.C.M., Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer, Lung cancer. 2013.
Li Y., Lam S.K. and Ho J.C.M., The Role of Erlotinib-induced Autophagy in Non-Small Cell Lung Carcinoma, Asian Pacific Society of Respirology. 2012.


Researcher : Lian Q

Project Title:The Roles of Mesenchymal Stem Cell Produced Stromal Cell-derived Factor-1 and Neuregulin-1 for Cardiac Progenitor Cell-mediated Myocardial Regeneration in Response to Heart Infarction
Investigator(s):Lian Q, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2010


Project Title:Functional Characterization of human iPSC- derived mesenchymal stem cells with cardiomyocyte potential
Investigator(s):Lian Q, Tse HF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011


Project Title:The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:01/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2013


Project Title:Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease
Investigator(s):Lian Q, Wong DSH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Ding Y. and Lian Q., Optimal cells for cardiac repair and regeneration Optimal cells for cardiac repair and regeneration Optimal cells for cardiac repair and regeneration , Cardiac regeneration and repair . RefineCatch Ltd, 2013, 1.
FU Q.L., Chow Y.Y., Sun S.J., Zeng Q.X., Li H.B., Shi J.B., Sun Y.Q., Wen W., Tse H.F., Lian Q. and Xu G., Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Rebalance Th1/th2 And Up-regulate Regulatory T Responses On Peripheral Blood Mononuclear Cells From Allergic Rhinitis Patients, Allergy. Wiley-Blackwell, 2012, Aug 1: doi: 10.1111/j.1398-9995.2012.02875.x..
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Lian Q., Editor Board , Journal of Ocular Biology . USA, Avens Publsihing Group, 2013.
Sun Y.Q., Deng M.X., He J., Tse H.F., Lian Q., Shi J. and Fu Q.L., Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice., Stem Cells. 2012, 2692-9.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : Liang RHS

List of Research Outputs

Wong K.Y., Yim R.L.H., Kwong Y.L., Leung C.Y., Hui P.K., Cheung F., Liang R.H.S., Jin D.Y. and Chim J.C.S., Epigenetic inactivation of the MIR129-2 in hematological malignancies, J Hematol Oncol. 2013, 6:16.


Researcher : Liang X

List of Research Outputs

LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : Liao S

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : Lie AKW

List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Cheung W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital, Intern Med J.. 2012, [Epub ahead of print].
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.
Hwang Y.Y., Sim P.Y.J., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment, Bone Marrow Transplantation. 2013, 48: 745-746.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor., American Journal of Hematology. 2013, 88(6): 485-491.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S.C., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Relapses of acute leuekmia after allogeneic hematopoietic stem cell transplantation: second transplantation with reduced intensity conditioning from the original donor, Am J Hematol. 2013, in press.
Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.


Researcher : Liu H

Project Title:Phenotypic analysis of LRRK2 R1441G knockin mouse and the pathological role of LRRK2 R1441G mutation in neurodegeneration in Parkinson’s Disease
Investigator(s):Liu H, Ho SL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2011


List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.


Researcher : Liu S

Project Title:Rescue of post ischemic myocardial dysfunction by human induced pluripotent stem cells via cell-to-cell mitochondrial transfer
Investigator(s):Liu S, Tse HF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


List of Research Outputs

Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Lo WK

List of Research Outputs

Ma K.M.M., Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Charlson Co-morbidity Index and albumin significantly associated with fracture risk in peritoneal dialysis patients , Nephrology (Carlton). 2013, 18(5): 365-368.
Ma K.M.M., Yap Y.H.D., Yip K.Y.P., Lui S.L. and Lo W.K., Staphylococcus aureus peritonitis in two peritoneal dialysis patients: an uncommon complication of peripheral intravenous catheter infection, Peritoneal Dialysis International. 2012, 32(5): 573-4.
Yap Y.H.D., Ma K.M.M., Yip T.P.S., Lui S.L. and Lo W.K., Peritoneal dialysis-related peritonitis caused by erosion of umbilical abscess into the peritoneal cavity, Peritoneal Dialysis International. 2012, 32(4): 483-4.


Researcher : Lo Y

List of Research Outputs

GAO Y., Li L.S.W., Chau L.H., Lo Y., Lau W.C.S. and Mok T.M.Y., Assessment of autonomic function in patients with a history of neuropsychiatric lupus, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.


Researcher : Lu S

List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.


Researcher : Lui OLK

Project Title:Induction of transplantation tolerance to human pluripotent stem cell-derived tissues
Investigator(s):Lui OLK, Chan CWY, Li RA
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Li R.A., Bu L. and Lui O.L.K., Human pluripotent stem cell-derived cardiovascular progenitors for heartregeneration, Drug Discovery Today: Disease Model. In press.. 2012.


Researcher : Lui SL

List of Research Outputs

Lui S.L., Yung S.S.Y., Yim A.S.Y., Wong K.M., Tong K.L., Wong K.S., Li C.S., Au T.C., Lo W.K., Ho Y.W., Ng F., Tang S.O.C. and Chan D.T.M., A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport, and Inflammation Markers: A Randomized Clinical Trial, American Journal of Kidney Diseases. 2012, In press.
Ma K.M.M., Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Charlson Co-morbidity Index and albumin significantly associated with fracture risk in peritoneal dialysis patients , Nephrology (Carlton). 2013, 18(5): 365-368.
Ma K.M.M., Yap Y.H.D., Yip K.Y.P., Lui S.L. and Lo W.K., Staphylococcus aureus peritonitis in two peritoneal dialysis patients: an uncommon complication of peripheral intravenous catheter infection, Peritoneal Dialysis International. 2012, 32(5): 573-4.
Yap Y.H.D., Ma K.M.M., Yip T.P.S., Lui S.L. and Lo W.K., Peritoneal dialysis-related peritonitis caused by erosion of umbilical abscess into the peritoneal cavity, Peritoneal Dialysis International. 2012, 32(4): 483-4.


Researcher : Luk JKH

List of Research Outputs

Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chu L.W. and Chan F.H.W., Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study, Journal of the American Medical Directors Association. 2012, 13(9): 782-7.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chan F.H.W. and Chu L.W., Prevalence of anemia in Chinese nursing home older adults: Implication of age and renal impairment [Epub ahead of print], Geriatrics & Gerontology International. 2012.


Researcher : Ma CH

List of Research Outputs

Ma C.H., Lee H.B., Clark K.J. and Ekker S.C., High efficiency in vivo genome engineering with a simplified 15-RVD GoldyTALEN design, PLOS ONE. PLOS, 2013, 8.
Neff K.L., Argue D.P., Ma C.H., Lee H.B., Clark K.J. and Ekker S.C., Mojo hand, a TALEN design tool for genome editing applications. , BMC Bioinformatics. BioMed Central, 2012, 14.


Researcher : Ma KMM

List of Research Outputs

Ma K.M.M., Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Charlson Co-morbidity Index and albumin significantly associated with fracture risk in peritoneal dialysis patients , Nephrology (Carlton). 2013, 18(5): 365-368.
Ma K.M.M., Yap Y.H.D., Yip K.Y.P., Lui S.L. and Lo W.K., Staphylococcus aureus peritonitis in two peritoneal dialysis patients: an uncommon complication of peripheral intravenous catheter infection, Peritoneal Dialysis International. 2012, 32(5): 573-4.
Yap Y.H.D., Ma K.M.M., Mok M.M., Tang S.O.C. and Chan D.T.M., Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis, Rheumatology (Oxford). 2013, 52(3): 480-6.
Yap Y.H.D., Ma K.M.M., Yip T.P.S., Lui S.L. and Lo W.K., Peritoneal dialysis-related peritonitis caused by erosion of umbilical abscess into the peritoneal cavity, Peritoneal Dialysis International. 2012, 32(4): 483-4.


Researcher : Mak JCW

Project Title:Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):Mak JCW, Chan MMW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2005


Project Title:Effects of cigarette smoke on regulation of the expression of adiponectin and its receptors in airway cells
Investigator(s):Mak JCW, Ip MSM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010


Project Title:Involvement of fatty acid-binding proteins in cigarette smoke-induced inflammatory responses in human airway epithelial cells
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Investigating the mechanisms of cigarette smoke-induced disruption of serotonin homeostasis in the airways in vitro and in vivo - relevant to chronic obstructive pulmonary disease
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012


Project Title:The role of visfatin in cigarette smoke-induced inflammatory responses in human airway epithelial cells and macrophages
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., LI X., Ip M.S.M. and Mak J.C.W., Alterations of cigarette smoke-induced lipid metabolism in rat heart and lung, Am. J. Respir. Crit. Care Med.. 2013, 187: A4841.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, 17th Congress of the Asian Pacific Society of Respirology (APSR) . Respirology, 2012, 17 (Suppl. 2): 50.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, Respirology. 2012, 17 (Suppl. 2): 50.
LIANG Y., Ip M.S.M. and Mak J.C.W., Cigarette smoke-induced angiogenesis through AMPK activation in rat heart, J. Hong Kong College of Cardiol.. 2012, 20: 50.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Lau K.W., Mak J.C.W., Chan K.H. and Law A.C.K., Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress, Neurotox Res. 2012, 22(2): 170-176.
Li Y., Lam S.K., Mak J.C.W., Zheng C. and Ho J.C.M., Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer, Lung cancer. 2013.
Mak J.C.W., Detection of potential biomarkers in airway diseases, Inhalation Asia 2013. 2013.
Mak J.C.W., Chu J.L., Yeung S.C., Chan M.M.W. and Ip M.S.M., Elevated plasma levels of growth differentiation factor (GDF)-15 in stable chronic obstructive pulmonary disease (COPD), Am. J. Respir. Crit. Care Med.. 2013, 187: A1526.
Mak J.C.W., Stem cells in lung diseases, 17th Congress of the Asian Pacific Society of Respirology (APSR). 2012.
YAU K.H., Mak J.C.W., Leung S.W.S., Yang D. and Vanhoutte P.M.G.R., A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat, PLOS One. 2012, 7: e45340.


Researcher : Mak W

List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Chang R.S., Mak H.K., Mak W. and Mok T.M.Y., Bithalamic stroke in a patient with systemic lupus erythermatosus, positive antiphospholipid antibodies and warfarin use, International Journal of Rheumatic Diseases. 2012, 15: e76-e77.
Chang S.K.R., Mak H.K.F., Mak W. and Mok T.M.Y., Bithalamic stroke in a patient with Systemic Lupus Erythematosus positive antiphospholipid antibodies and warfarin use. , International Journal of Rheumatic Diseases.. 2012, 15(4): e76-77.
Chang S.K.R., Mak W., Cheung R.T.F. and Ho S.L., Perioperative ischemic stroke. In: Ischemic Stroke: symptoms, prevention and recovery., In: V Lakatos, B Somogyi, New York, Nova Science Publishers Inc, 2013, 191-207.
Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Man CH

List of Research Outputs

Leung A.Y.H., Man C.H. and Kwong Y.L., FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia., Leukemia. 2013, 27(2): 260-8.


Researcher : Mok TMY

Project Title:The role of matrix metalloproteinases and tissue inhibitor of metalloproteinases in neuropsychiatric lupus
Investigator(s):Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:The generation of a mouse model to study the role of IL-33 in systemic lupus erythematosus
Investigator(s):Mok TMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Chang R.S., Mak H.K., Mak W. and Mok T.M.Y., Bithalamic stroke in a patient with systemic lupus erythermatosus, positive antiphospholipid antibodies and warfarin use, International Journal of Rheumatic Diseases. 2012, 15: e76-e77.
Chang S.K.R., Mak H.K.F., Mak W. and Mok T.M.Y., Bithalamic stroke in a patient with Systemic Lupus Erythematosus positive antiphospholipid antibodies and warfarin use. , International Journal of Rheumatic Diseases.. 2012, 15(4): e76-77.
GAO Y., Li L.S.W., Chau L.H., Lo Y., Lau W.C.S. and Mok T.M.Y., Assessment of autonomic function in patients with a history of neuropsychiatric lupus, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
Li P.H., Wong W.H.S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Tong K.L., Tse N.K.C., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chong C.Y., Wong R.W.S., Mok T.M.Y., Ying S.K.Y., Fung S.K.S., Lai W.M., Yang W. and Lau Y.L., Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese, Rheumatology. Oxford, 2013, 52(2): 337-345.
Mok T.M.Y., Autoimmune problems in pregnancy, Hospital Authority Commissioned training in Obstetrics and Gynaecology 2012/2013, Feb 2013. 2013.
Mok T.M.Y., Novel therapy in the treatment of systemic lupus erythematosus, The Hong Kong Medical Forum, Department of Medicine, The University of Hong Kong, May 2013. 2013.
Mok T.M.Y., Pregnancy in rheumatic diseases, Certificate course in rheumatology nursing. Institute of Advanced Nursing Studies, Jan 2013. 2013.
Mok T.M.Y., Pregnancy issues and management in patients with systemic lupus erythematosus, The University of Hong Kong & Shenzhen Hospital Rheumatology Congress May 2013, Shenzhen, China. 2013.
Mok T.M.Y., Rheumatoid arthritis and periodontal disease (Plenary lecture), Ten Topics in Asia, Singapore, Oct 2012. 2012.
Mok T.M.Y., T cell-B cell interaction in systemic lupus erythematosus (Plenary lecture), Lupus congress, Manila, Philippines, Nov 2012. 2012.
Mok T.M.Y., The pathogenesis of neuropsychiatric lupus, The Mary Kirkland Centre of Lupus care special lecture series. New York, USA, Sept 2012. 2012.
Tsang H.L., Chung H.Y., Mok T.M.Y. and Lau W.C.S., Kinase Inhibitors for the Treatment of Rheumatoid Arthritis, Hong Kong Bulletin on Rheumatic Diseases. 2012, 12: 43-49.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.
Yang W., Tang H., Zhang Y., Tang X., ZHANG J., Sun L., Yang J., Cui Y., Zhang L., Hirankarn N., Cheng H., Pan H.F., Gao J., Lee T.L., Sheng Y., Lau W.C.S., Li Y., Chan T.M., Yin X., Ying D., Lu Q., Leung A.M.H., Zuo X., Chen X., Tong K.L., Zhou F., Diao Q., Tse N.K.C., Xie H., Mok C.C., Hao F., Wong S.N., Shi B., Lee K.W., Hui Y., Ho M.H.K., Liang B., Lee P.P.W., Cui H., Guo Q., Chung B.H.Y., Pu X., Liu Q., Zhang X., Zhang C., Chong C.Y., Fang H., Wong R.W.S., Sun Y., Mok T.M.Y., Li X.P., Avihingsanon Y., Zhi Z., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Gao F., Shotelersuk V., Kang X., Ying S.K.Y., Zhang L., Wong W.H.S., Zhu D., Fung S.K.S., Zeng F., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Shen N., Tam P.K.H., Sham P.C., Ye D.Q., Yang S., Zhang X. and Lau Y.L., Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians, The American Journal of Human Genetics. 2013, 92: 41-51.
Zhang J., Zhang Y., Zhang L., Yang J., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Lau Y.L. and Yang W., Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients, Annals of Human Genetics. 2013, 77(4): 344-350.


Researcher : NG YM

List of Research Outputs

Frontini M., Kukalev A., Leo E., Ng Y.M., Cervantes M., Cheng C.W., Holic , Dormann , Tse E.W.C., Pommier Y. and Yu C.C.P.V., The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment, Developmental Cell. 2012, 23(2): 356–370.
Grey W., Izatt L., Sahraoui W., NG Y.M., Ogilvie C., Hulse A., Tse E.W.C., Holic R. and Yu C.C.P.V., Deficiency of the Cyclin-Dependent Kinase Inhibitor, CDKN1B, Results in Overgrowth and Neurodevelopmental Delay, Human Mutation. 2013, 34(6): 864-868.


Researcher : Ng KM

Project Title:Creation of a LAMP2-deficient human pluripotent stem cell-based model for studying lysosomal dysfunction induced cardiomyopathy
Investigator(s):Ng KM, Tse HF, Siu DCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2012


List of Research Outputs

Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.


Researcher : Ng YM

List of Research Outputs

Frontini M., Kukalev A., Leo E., Ng Y.M., Cervantes M., Cheng C.W., Holic , Dormann , Tse E.W.C., Pommier Y. and Yu C.C.P.V., The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment, Developmental Cell. 2012, 23(2): 356–370.
Grey W., Izatt L., Sahraoui W., NG Y.M., Ogilvie C., Hulse A., Tse E.W.C., Holic R. and Yu C.C.P.V., Deficiency of the Cyclin-Dependent Kinase Inhibitor, CDKN1B, Results in Overgrowth and Neurodevelopmental Delay, Human Mutation. 2013, 34(6): 864-868.


Researcher : Ong KL

List of Research Outputs

WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.


Researcher : Pai MCP

List of Research Outputs

Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatol Curr Res. 2013, S5: 002.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatology: Current Research. OMICS Publishing Group, 2013, S5: 002.


Researcher : Pang AWK

List of Research Outputs

Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.


Researcher : Pang R.W.C.

Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang RWC

Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang SYY

List of Research Outputs

Chang C., Hon F.K.S., Kwan W.M.M., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 13.
Kwan W.M.M., Hon F.K.S., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Chang C., Ho S.L., Cheung R.T.F. and Mak W., First year of 24/7 Acute Stroke Unit. Part 1: eligibility and utilization of intravenous thrombolysis, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.


Researcher : Poon MW

Project Title:The Roles and Mechanisms of RAP1/NF kappa B Pathway in Modulation of Corneal Wound Healing
Investigator(s):Poon MW, Lian Q
Department:Eye Institute
Source(s) of Funding:Small Project Funding
Start Date:06/2012
Completion Date:06/2013


List of Research Outputs

Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : Ramsden DB

List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.


Researcher : SAMARANAYAKE NR

List of Research Outputs

Cheung B.M.Y., Samaranayake N.R. and Chui W.C.M., Medication Incidents related to technology in a University-affiliated general hospital in 2006-2010, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.
SAMARANAYAKE N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of the discovery of medication errors in a tertiary hospital in Hong Kong., International Journal of Clinical Pharmacy. 2013, 35(3): 432-8.
Samaranayake N.R., Cheung S.T.D., Cheng K., Lai K., Chui C.M.W. and Cheung B.M.Y., A pharmacy-led bar-code assisted medication administration system – changes to the pharmacy process and user attitudes., Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.


Researcher : SHU L

List of Research Outputs

Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.


Researcher : Samaranayake NR

List of Research Outputs

Cheung B.M.Y., Samaranayake N.R. and Chui W.C.M., Medication Incidents related to technology in a University-affiliated general hospital in 2006-2010, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Cheung C.L., Cheung T.T., Samaranayake N.R. and Cheung B.M.Y., Hay fever and hypertension in the US adult population, Journal of the Hong Kong College of Cardiology. Young Investigator Award presentation at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 55.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.
SAMARANAYAKE N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of the discovery of medication errors in a tertiary hospital in Hong Kong., International Journal of Clinical Pharmacy. 2013, 35(3): 432-8.
Samaranayake N.R., Cheung S.T.D., Cheng K., Lai K., Chui C.M.W. and Cheung B.M.Y., A pharmacy-led bar-code assisted medication administration system – changes to the pharmacy process and user attitudes., Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.


Researcher : Seto WKW

Project Title:Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure
Investigator(s):Seto WKW, Kwong YL, Lie AKW, Wong DKH, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2013


Project Title:Association between IL-1B, PSCA and MUC1 genes polymorphism with E-cadherin methylation and H. pylori infection to gastric cancer susceptibility
Investigator(s):Seto WKW, Huang FY, Chu KM, Yuen RMF, Leung WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Fung J.Y.Y., Lee C.K., Chan M., Seto W.K.W., Lai C.L. and Yuen R.M.F., High prevalence of non-alcoholic fatty liver disease in the Chinese – results from the Hong Kong liver health census. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands 24–28 April 2013, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S538.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Levels of HBV DNA and not HBsAg are associated with biochemical flares after HBeAg seroconversion, Hepatology International. 2012, 6: 52.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Chan A.C.Y., Sharr W.W., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B – long term outcome. (Oral presentation at the Transplant Plenary II Session of the 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 11, 2012), Hepatology. 2012, 56(S1): 196A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Yuen R.M.F., Chok K.S.H., Sharr W.W., Chan A.C., Cheung T.T., Seto W.K.W., Fan S.T., Lai C.L. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B, American Journal of Gastroenterology. 2013, 108(6): 942-8.
Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.
Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Lam Y.F., Seto W.K.W., Tong S.M. and Leung W.K., Findings On Surveillance Colonoscopy In Patients With Serrated Lesions Of The Colon, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Liu S.K., Tong S.M., Seto W.K.W. and Hung I.F.N., Occult hepatitis B infection in patients with inflammatory bowel disease, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Seto W.K.W., Chan K.H., Tong S.M. and Hung I.F.N., Prevalence Of Past Or Current Hepatitis B Infection And Factors For Non-vaccination In Chinese Patients With Inflammatory Bowel Diseases, The 1st Meeting of Asian Organization for Crohns’s and Colitis in Tokyo, Japan. 2013.
Liu K.S.H., Seto W.K.W., Hung I.F.N. and Leung W.K., 10-day Sequential Versus 10-day Bismuth-Containing Quadruple Therapy As Empirical First-Line Treatment for Helicobacter pylori: An Open Label Randomized Crossover Trial, Digestive Disease Week, Orlando, USA. 2013.
Seto W.K.W., 2nd Conference of Macau Society of Gastroenterology and Hepatology, Macau Society of Gastroenterology and Hepatology. 2012.
Seto W.K.W., Beijing-Hong Kong Medical Forum 2013, 2013.
Seto W.K.W., Distinguished Research Paper Award for Young Investigator 2013, Hong Kong College of Physicians. 2013.
Seto W.K.W., Distinguished Research Paper Award for Young Investigator, Hong Kong College of Physicians. 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Fung J.Y.Y., Yuen R.M.F. and Lai C.L., Future prevention and treatment of chronic hepatitis B infection. , J Clin Gastroenterol. 2012, 46(9): 725-34.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B surfact antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 257.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Hong Kong Association for the Study of Liver Diseases Annual Scientific Meeting, Hong Kong Association for the Study of Liver Diseases. 2012.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Reply to Liao et al, Clin Infect Dis. 2013.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serologic and virologic outcomes of tenofovir in Asian chronic hepatitis B patients with prior nucleoside analogue exposure. (Poster presentation at the 63rd) Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 10, 2012, Hepatology. 2012, 56(S1): 415A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Seto W.K.W., Lam Y.F., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen levels during five years entecavir therapy in Asian chronic hepatitis B patients., The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S314.
Seto W.K.W., Hui A.J., Wong V.W.S., Wong G.L.H., Liu K., Lai C.L., Yuen R.M.F. and Chan H.L.Y., Serum hepatitis B surface antigen levels to guide the cessation of entecavir in hepatitis B e antigen-negative chronic hepatitis B: an interim analysis. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S315.
Seto W.K.W., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B monoinfection, Hepatology International. 2013, 7(2): 327-34.
Seto W.K.W., World Journal of Hepatology. Baishideng Publishing Group, 2013.
Seto W.K.W., Young Investigator Research Grant 2012, Hong Kong College of Physicians. 2012.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatol Curr Res. 2013, S5: 002.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatology: Current Research. OMICS Publishing Group, 2013, S5: 002.


Researcher : Shen J

Project Title:Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):Shen J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2003


Project Title:Elucidating caveolin-1 as a negative modulating protein for proliferation of neural stem/progenitor cells and neural differentiation in post-ischemic brain
Investigator(s):Shen J, Chung SK, So KF
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2010


Project Title:Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cererbal ischemia-reperfersion models
Investigator(s):Shen J, Cheung RTF, Chung SK, Siu DCW, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions
Investigator(s):Shen J, Yang D, So KF
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Using Ski as a molecular target for seeking active compounds from Qingyihuaji (QYHJ) formula for inhibiting pancreatic cancer stem cells
Investigator(s):Shen J, Chen J
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:06/2012


Project Title:7th Conference on Metal Toxicity & Carcinogenesis; An Unanswered Question about Heavy Metals in Chinese Herbal Medicinal Preparations: Environmental Contamination or Medicinal Elements?
Investigator(s):Shen J
Department:School of Chinese Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions
Investigator(s):Shen J, Chung SK, So KF, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions
Investigator(s):Shen J, Yang D, Chen X
Department:School of Chinese Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Effects of endosomal adaptor protein for regulating cell fate decision during differentiation of neural stem/progenitor cells
Investigator(s):Shen J, So KF, Chung SK
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013




Researcher : Shiu SWM

List of Research Outputs

Lam K.Y.J., Wong Y., Shiu S.W.M., Betteridge D.J. and Tan K.C.B., Effect of insulin on the soluble receptor for advanced glycation end products (RAGE)., Diabetic Medicine. UK, Wiley, 2013, 30: 702-709.
Lam K.Y.J., Wang Y., Shiu S.W.M., Wong Y. and Tan K.C.B., Soluble receptor for advanced glycation end-products in Chinese Type 1 diabetic patients., The 9th International Diabetes Federation Western pacific Region Congress, Kyoto, Japan. 2012.
Shiu S.W.M., Wong Y. and Tan K.C.B., Effect of advanced glycation end products on letin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells., J Atheroscler Thromb. 2012, 19(12): 1083-92.
TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.
Tan K.C.B., Shiu S.W.M. and Wong Y., Advanced glycation endproducts induce lectin-like oxidized lipoprotein receptor-1 expression via mammalian target of rapamycin. , The International Diabetes Federation 21st World Diabetes Congress, Dec 2011, Dubai.. 2012.


Researcher : Sim PYJ

List of Research Outputs

Hwang Y.Y., Sim P.Y.J., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment, Bone Marrow Transplantation. 2013, 48: 745-746.
Sim P.Y.J., Hwang Y.Y., Leung R.Y.Y., So J.C.C. and Kwong Y.L., Histiocytic sarcoma simulating immune thrombocytopenic purpura, Ann Hematol. 2013, 92(4): 555-6.


Researcher : Singh GH

List of Research Outputs

Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.


Researcher : Siu DCW

Project Title:Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:Human Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia
Investigator(s):Siu DCW, Ho WL, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2012


List of Research Outputs

Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
JIM M.H., TSUI K.L., CHEUNG G.S., Siu D.C.W., Ho H.H., Chow W.H., LI S.K. and Yiu K.H., Jeopardised Inferior Myocardium (JIM) Score: An Arithmetic Electrocardiographic Score to Predict the Infarct-Related Artery in Inferior Myocardial Infarction., Annals Academy Medicine Singapore. 2012, 41(7): 300-4.
Lau C.P., Tse H.F., Siu D.C.W. and Gbadebo D., Atrial electrical and structural remodeling: implications for racial differences in atrial fibrillation., In: Eric N. Prystowsky, Journal of Cardiovascular Electrophysiology. Wiley Periodicals, Inc., 2012, 23 Suppl 1: S36-40.
Lau C.P., Gbadebo D.T., Connolly S.J., Van G.E.L.D.E.R. .I.C., Capucci A., Gold M.R., Israel C.W., Morillo C.A., Siu D.C.W., Abe H., Carlson M. and Tse H.F., Ethnic difference in atrial fibrillation identified using implanted cardiac devices., J Cardiovasc Electrophysiology. 2013, 24: 381-387.
Lau C.P., Gbadebo D.T., Connolly S.J., Van Gelder I.C., Capucci A., Gold M.R., Israel C.W., Morillo C.A., Siu D.C.W., Abe H., Carlson M., Hohnloser S.H. and Healey J.S., Ethnic differences in atrial fibrillation identified using implanted cardiac devices., In: Eric N. Prystowsky, Journal of Cardiovascular Electrophysiology. 2013 Wiley Periodicals, Inc., 2013, 24: 381-387.
Lau C.P., Siu D.C.W. and Tse H.F., Pacing inducibility for atrial fibrillation: A test tested?, J Cardiovasc Electrophysiol. . 2013.
Lau C.P., Siu D.C.W. and Tse H.F., The future of implications for cardiac rhythm management, Circulation. 2013, 128: 687-93.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Li R.A., Ji-Dong Fu J.D.F., Siu D.C.W., Jennifer C. Moore J.M., Deborah K. Lieu D.L., Valeriy Timofeyez V.T., Nipavan Chiamvimonvat N.C., Tse H.F. and Gordon Keller G.K., Identification of a common determinant for the immature properties of derived human cardiomyocytes enables mechanism-based driven maturation, Circulation. . 2012.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Siu D.C.W., 2012 Invited Speaker, European Society of Cardiology Congress, 2012, Munich, Germany, 2012.
Siu D.C.W., 17. 2012 Invited Speaker, Bayer’s Internal Training Workshop for Stroke Prevention of Atrial Fibrillation (SPAF): Clinical Practice management in SPAF, 2012.
Siu D.C.W., 2012 Advisory Board Meeting, First Cardiovascular League of Experts in Asia Pacific (CV LEAP) Singapore, 2012.
Siu D.C.W., 2012 Invited Speaker, APHRS, Taipei, Taiwan :AAD/OAC(2) Safety and Efficacy of Warfarin in Chinese AF Patients, AAD/OAC Con: Patients with AF on Warfarin Should be Seitched to Dabigatran , 2012.
Siu D.C.W., 2012 Invited Speaker, American Heart Association Scientific Sessions US, 2012.
Siu D.C.W., 2013 Invited Speaker, Multi-specialty medical Mega Conference Third Round” Stem Cells in Cardiology”, 2013.
Siu D.C.W., 2013 Advisory Board Meeting, Second Cardiovascular League of Experts in Asia Pacific (CV LEAP) Taipei, Taiwan , 2013.
Siu D.C.W., 2013 Advisory Board Meeting, St Jude Advisory Board Meeting on High Viltage Lead Technology and Cardiac Resynrchronization Therapy, Beijing, China, 2013.
Siu D.C.W., 2013 Chair, Heart Rhythm 2013, Denver, US “Optimizing Patient Benefits in Heart Failure Devices, 2013.
Siu D.C.W., 2013 Invited Speaker, ODYSSEY Outcomes Investigator Meeting for Protocol EFC11570, Sydney, Australia , 2013.
Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.
Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Yeung C.Y., Lam K.S.L., Li L.S.W., Lam K.F., Tse H.F. and Siu D.C.W., Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia., Diabetes Care. 2012, 35(12): 2564-9.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.
Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.
Zhao C., Wang M.M., Siu D.C.W., Hou Y.L., Wang T., Tse H.F. and Yiu K.H., Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress , Cardiovasc Diabetol. . 2012, 5:11(1): 147.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Siu SC

List of Research Outputs

Wong C.K.H., Fung S.C.C., Siu S.C., Lo Y.C.Y., Wong K.W., Fong D.Y.T. and Lam C.L.K., A Short Message Service Intervention to Prevent Diabetes for Chinese Professional Drivers: A Single-blinded Randomized Controlled Trial, Journal of Diabetes Investigation. 2012, 3 (Suppl 1): 263-4.
Wong C.K.H., Fung S.C.C., Siu S.C., Lo Y.C.Y., Wong K.W., Fong D.Y.T. and Lam C.L.K., A Short Message Service Intervention to Prevent Diabetes for Chinese Professional Drivers: A Single-blinded, Randomized Controlled Trial, 9th IDF-WPR Congress and 4th AASD Scientific Meeting, Kyoto International Conference Center, 24-27 November 2012. Japan, 3 (Suppl 1): 263-264.


Researcher : So HF

List of Research Outputs

Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.


Researcher : Soong SS

List of Research Outputs

Cheung E., Bow H.Y.C., Loong C., Lee K.K., Ho A.Y.Y., Soong S.S., Chan Y.Y. and Kung A.W.C., A secular increase in BMD in Chinese women., Journal of Bone and Mineral Metabolism. 2013.


Researcher : Sun H

List of Research Outputs

Li G.R., Chen K. and Sun H., Distinctive density,biophysical properties, and pharmacology of voltage-gated sodium current in atrial and ventricular myocytes. Heart Rhythm 34th Annual Scientific Sessions. May 8-11, 2013. Denver, Colorado, USA, Heart Rhythm . 2013, 10(5S): S322.
Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Wu W., Sun H., Deng X.L. and Li G.R., EGFR Tyrosine kinase regulates small conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK 293 cells, Biochem J. 2013, 452(1): 121-129.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.


Researcher : TSUN GS

List of Research Outputs

TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.


Researcher : Tam CCT

List of Research Outputs

Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).


Researcher : Tam CY

List of Research Outputs

Chan V.S.F., Tsang H.L., Tam C.Y., Lu L. and Lau W.C.S., B-cell-targeted therapies in systemic lupus erythematosus., Cellular & Molecular Immunology. 2013, 10(2): 133-42.


Researcher : Tam S

List of Research Outputs

Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.


Researcher : Tan KCB

Project Title:Carbamylated LDL and diabetes
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:02/2013


Project Title:Advanced glycation end product receptors in diabetes
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


List of Research Outputs

Cheung C.L., Tan K.C.B., Lam K.S.L. and Cheung B.M.Y., The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: A structural equation modeling approach., Journal of Clinical Endocrinology and Metabolism. 2013.
Colhoun H.M., Betteridge D.J., Durrington P., Hitman G., Neil A., Livingstone S., Charlton-Menys V., Bao W., Demicco D.A., Preston G.M., Deshmukh H., Tan K.C.B. and Fuller J.H., Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. , Diabetes.. 2012, 60: 2379-85.
Kim S., Oh K.H., Oh J., Kim S.J., Chung W., Song Y.R., Na K.Y., Oh Y.K., Ahn C., Kim S.G. and Tan K.C.B., Biocompatible peritoneal dialysis solution preserves residual renal function., American Journal of Nephrology. 2012, 36(4): 305-16.
Kumana C.R., Tan K.C.B. and Cheung B.M.Y., Intensive glucose lowering for diabetes: long-term impact on absolute mortality. , Presented at the 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Lam K.Y.J., Wong Y., Shiu S.W.M., Betteridge D.J. and Tan K.C.B., Effect of insulin on the soluble receptor for advanced glycation end products (RAGE)., Diabetic Medicine. UK, Wiley, 2013, 30: 702-709.
Lam K.Y.J., Wang Y., Shiu S.W.M., Wong Y. and Tan K.C.B., Soluble receptor for advanced glycation end-products in Chinese Type 1 diabetic patients., The 9th International Diabetes Federation Western pacific Region Congress, Kyoto, Japan. 2012.
Loong C.H.N., Woo Y.C., Leung E.L.Y., Yee S.W., Leung C.Y., Wong Y.F., Hui Y.L.E., Tan K.C.B. and Lam K.S.L., Consolidating service receivers: Nurse-led Clinic in the Management of Osteoporosis to Reinforce Lifestyle Modification, Increase Drug-adherence Rate and Osteoporosis Clinic Attendance Rate at Queen Mary Hospital, HA Convention 2013.
Loong H.N.C., Woo Y.C., Leung L.Y.E., Lam K.Y.J. and Tan K.C.B., Risk factors related to Chinese population with fracture., 3rd Asia-Pacific Osteoporosis Meeting, Kuala Lumpur, Malaysia.. 2012.
Shiu S.W.M., Wong Y. and Tan K.C.B., Effect of advanced glycation end products on letin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells., J Atheroscler Thromb. 2012, 19(12): 1083-92.
TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.
Tan K.C.B., Shiu S.W.M. and Wong Y., Advanced glycation endproducts induce lectin-like oxidized lipoprotein receptor-1 expression via mammalian target of rapamycin. , The International Diabetes Federation 21st World Diabetes Congress, Dec 2011, Dubai.. 2012.
Tan K.C.B., Beijing Baishideng BioMed Scientific Co. Ltd., World Journal of Diabetes. 2012.
Tan K.C.B., Bentham Science Publishers, The Open Diabetes Journal. 2012.
Tan K.C.B., Bentham Science Publishers, The Open Translational Medicine Journal. 2012.
Tan K.C.B., Chairman of the Scientific Committee of the Seventh International Huaxia Congreee of Endocrinology., Scientific Committee of the Seventh International Huaxia Congreee of Endocrinology.. 2012.
Tan K.C.B., DPP-4 inhibitors: similarities and differences., Annual Scientific Conference of the Hong Kong Association for the Study of Obesity, Hong Kong.. 2013.
Tan K.C.B., Elsevier., Obesity Research & Clinical Practice.. 2013.
Tan K.C.B., Journal of Diabetes Investigation, 2012.
Tan K.C.B., Soluble RAGE in Diabetes., 12th International Congress on Amino Acids, Peptides and Protein, Aug 2011, Beijing.. 2012.
Tan K.C.B., Soluble receptor for advanced glycation end products in diabetes., 7th International Huaxia Congress of Endocrinology, Hong Kong.. 2012.
Tan K.C.B., Type 1 diabetes in young adults., Hong Kong Juvenile Diabetes Association Annual Scientific Conference, Hong Kong.. 2013.
Tan K.C.B., Update on lipid management in Hong Kong : statin and beyond., CME meeting for Physicians. Tuen Mun Hospital, Hong Kong.. 2012.
Tan K.C.B., Wiley-Blackwell., Clinical obesity.. 2013, 2012-2013.
Wong K.K.C., Hui Y.L.E., Tan K.C.B., Chow W.S., Woo Y.C., Yeung C.Y., Leung C.Y., Yee A.S.W., Leung E.L.Y. and Lam K.S.L., Improving Glycaemic Control in the Management of Diabetes – the Role of Continuous Glucose Monitoring in Diabetes Nurse Clinic, HA Convention CGM. 2013.
Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Tan V.P.Y.

Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


List of Research Outputs



Researcher : Tan VPY

Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


List of Research Outputs

Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Tan V.P.Y. and Lui P.C., Detection rates of proximal or large serrated polyps in Chinese patients undergoing screening colonoscopy, J Dig Dis. 2012, 13(9): 466-71.
Tan V.P.Y., Lee Y.T. and Poon T.C.J., Incarceration of a colonoscope in an inguinal hernia: case report and literature review, World Journal of Gastrointestinal Endoscopy . 2013, 5(6): 304-307.
Tan V.P.Y., Cheung T.K., Wong W.M., Pang R.W.C. and Wong B.C.Y., Treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot study, World Journal of Gastroenterology. 2012, 18(42): 6127-6133.
Tan V.P.Y., Chung A., Yan B.P. and Gibson P.R., Venous And Arterial Disease In Inflammatory Bowel Disease., In: Mamoru Watanabe, Journal Of Gastroenterology & Hepatology. Wiley Publishing Asia, 2013, 28: 1095-113.


Researcher : Tang CW

Project Title:Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Potential therapeutic role of bone marrow-derived mesenchymal stromal/stem cells in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:ISN Forefronts Symposium on “Tubulointerstitial Disease in Diabetic Nephropathy”; The TLR4 antagonist CRX-526 attenuates glucose-induced overproduction of osteopontin in cultured proximal tubular epithelial cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):Tang SCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


List of Research Outputs



Researcher : Tang SCW

Project Title:Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Potential therapeutic role of bone marrow-derived mesenchymal stromal/stem cells in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:ISN Forefronts Symposium on “Tubulointerstitial Disease in Diabetic Nephropathy”; The TLR4 antagonist CRX-526 attenuates glucose-induced overproduction of osteopontin in cultured proximal tubular epithelial cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):Tang SCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
LIM A.I., Tang S.C.W., Chan Y.Y., Lai K.N. and Leung J.C.K., Chemokines Usage by Tubular Epithelial Cells in IgA Nephropathy: Role of TNF-α and Angiotensin II, J Am Soc Nephrol. 2012, 23: 854A.
LIM A.I., Tang S.C.W., Lai K.N. and Leung J.C.K., Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?, Journal of Cellular Physiology. 2013, 228: 917-924.
LIU J., Lee C.K.F., Sze C.W., Tong Y., Tang S.C.W., Ng T.B. and Zhang Y., Experimental studies on intestinal absorption and bioavailability of traditional Chinese medicines: Recent progress and implication for quality control., In: LIU JY, LEE KF, SZE CW, TONG Y, TANG CW, NG TB, YB ZHANG*. , 11th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Aug 21-23, 2012, Macau, China.. 2012.
LIU J., Lee C.K.F., Sze C.W., Tong Y., Tang S.C.W., Ng T.B. and Zhang Y., Experimental studies on intestinal absorption and bioavailability of traditional Chinese medicines: Recent progress and implication for quality control, In: Liu JY, KF Lee, Sze CW, Tong Y, Tang CW, Ng TB, Zhang YB*, Journal of pharmacy and pharmacology. 2013, 65(5): 621-33.
Lam Y., Sze C.W., Tong Y., Tang S.C.W., Ho J.C.M., Liao Q.X., Lin X. and Zhang Y., Research on the allelopathic potential of wheat, In: Y Lam, CW Sze, Y Tong, TB Ng, Tang CW, Ho CW, QX Liao, X Lin, YB Zhang*, Agricultural Sciences. 2012, 3: 979-985.
Leung J.C.K., LIM A.I., Chan Y.Y., Tang S.C.W. and Lai K.N., Dual Blockade of Angiotensin II and Prorenin Receptors Ameliorates Podocytic Apoptosis in IgA Nephropathy through Inhibition of the Notch Signaling Pathway, J Am Soc Nephrol. 2012, 23: 322A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
Lin X., Sze C.W., Ng T.B., Tong Y., Shaw P.C., Tang S.C.W. and Zhang Y., Polysaccharides of Dendrobium officinale inhibit TNF-α-induced apoptosis in A-253 cell line, In: Xiang L, Stephen Sze CW, Ng TB, Tong Y, Shaw PC, Sydney Tang CW, Kalin Zhang YB*, Inflamm Res.. 2013, 62(3): 313-24.
Liu J.I.N.G.-.Y.I., Lee C.K.F., Sze C.W., Tong Y., Tang S.C.W., Ng T.Z.I. .U.N. and Zhang Y., Intestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control, Journal of pharmacy and pharmacology. 2012, 65 (5): 621-633.
Ma L.J., Murea M., Snipes J.A., Marinelarena A., Kruger J., Hicks P.J., Langberg K.A., Bostrom M.A., Cooke J.N., Suzuki D., Babazono T., Uzu T., Tang S.C.W., Mondal A.K., Sharma N.K., Kobes S., Antinozzi P.A., Davis M., Das S.K., Rasouli N., Kern P.A., Shores N.J., Rudel L.L., Bluher M., Stumvoll M., Bowden D.W., Maeda S., Parks J.S., Kovacs P., Hanson R.L., Baier L.J., Elbein S.C. and Freedman B.I., An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects, PLoS One. 2013, 8(2): e56193.
SONG J., Shaw P.C., Wong N.S., Sze C.W., Yao X.S., Tang S.C.W., Tong Y. and Zhang Y., Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP(+), but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells, Neurosci Lett.. 2012, 521(1): 76-81.
SONG T., Lee C.K.F., Sze C.W., Tong Y., Tang S.C.W., Leung G.P.H. and Zhang Y., A Novel Method for Quality Control of Chinese Medicines in vivo/vitro. , In: Song TH, Calvin Lee KF, Stephen Sze CW, Tong Y, Sydney Tang CW, George Leung PH, Kalin Zhang YB*., 11st Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Aug 21-23, 2012, Macao, China. . 2012.
Tang S.C.W., (1) Fluid leakage as a cause of ultrafiltration failure in peritoneal dialysis; (2) Fluid, apnea and CV morbidity in peritoneal dialysis, Peritoneal Dialysis Research Training Course, Sun Yat-sen University (Guangzhou, China). 2012.
Tang S.C.W., Combination therapy against the RAS for CKD: friend or foe?, 4th Quadrangular Chinese Nephrologist Meeting and the 5th Congress of the International Society for Hemodialysis (Taipei, Taiwan). 2012.
Tang S.C.W., Diabetic nephropathy - an emerging entity, World Congress of Nephrology (Hong Kong). 2013.
Tang S.C.W., Diabetic nephropathy - from bench to bedside, 7th International Huaxia Congress of Endocrinology (Hong Kong). 2012.
Tang S.C.W. and Lai K.N., Hepatitis C Virus-Associated Glomerulonephritis, Contributions to Nephrology. 2013, 181: 194-206.
Tang S.C.W. and Lai K.N., Hepatitis C virus-associated glomerulonephritis, In: Nan Chen, New Insights into Glomerulonephritis. Basel, Switzerland, S Karger AG, 2013, 194-206.
Tang S.C.W., IgA nephropathy: an update on pathological classification and treatment approach, Nephrology and Pathology Joint Symposium in celebration of the 30th anniversary of the Taichung Veterans General Hospital (Taichung, Taiwan). 2012.
Tang S.C.W., Lam B., Lam J.C., Chan C.K., Chow C.C., Ho Y.W., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, Nephrology Dialysis Transplantation . 2012, 27: 2788-2794.
Tang S.C.W., Kidney International, Editorial Board. Nature Publishing Group, 2012.
Tang S.C.W., King's/HKU Fellowship Award, HK$ 50,000, The University of Hong Kong. 2013.
Tang S.C.W., Podocyte and glomerular-interstitial cross talk in IgA Nephropathy, 13th International Symposium on IgA Nephropathy (Nanjing, China). 2013.
Tang S.C.W., Yap Y.H.D. and Ma M.K.M., Prospective Randomized Trial of Effect of Direct Renin Inhibition in Non-Diabetic Chronic Kidney Disease (DRINK): An Interim Analysis, American Society of Nephrology. 2012.
Tang S.C.W., Proteinuria and the proximal tubular epithelial cell, Forefronts in Glomerular Disease - Nanjing Forum 2012 cum International Society of Nephrology Global Outreach CME Course (Nanjing, China). 2012.
Tang S.C.W., Toll-like receptors in renal fibrosis, WCN 2013 Satellite Symposium on “Renal Fibrosis: New Insights into the Pathogenesis and Therapeutics” (Guangzhou, China). 2013.
Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Tang SOC

List of Research Outputs

Lui S.L., Yung S.S.Y., Yim A.S.Y., Wong K.M., Tong K.L., Wong K.S., Li C.S., Au T.C., Lo W.K., Ho Y.W., Ng F., Tang S.O.C. and Chan D.T.M., A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport, and Inflammation Markers: A Randomized Clinical Trial, American Journal of Kidney Diseases. 2012, In press.
Yap Y.H.D., Ma K.M.M., Mok M.M., Tang S.O.C. and Chan D.T.M., Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis, Rheumatology (Oxford). 2013, 52(3): 480-6.


Researcher : Tang YF

List of Research Outputs

Yau T.C.C., Cheung F.Y., Lee F., Choo S.P., Wong H.Y.H., Toh H.C., Leung A.K., Chan P., Yau T.K., Wong J., Tang Y.F., Lau S.M., Cheung T.T., Fan S.T. and Poon R.T.P., A multicenter phase II study of sorafenib, capecitabine, and oxaliplatin (SECOX) in patients with advanced hepatocellular carcinoma: final results of Hong Kong-Singapore Hepatocellular Carcinoma Research Collaborative Group study, The American Society of Clinical Oncology Annual Meeting, Chicago, U.S.A., 31 May - 4 June 2013. Abstract 4117.


Researcher : Tong SM

List of Research Outputs

Lam Y.F., Seto W.K.W., Tong S.M. and Leung W.K., Findings On Surveillance Colonoscopy In Patients With Serrated Lesions Of The Colon, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Hung I.F.N., Tong S.M. and Chu K.M., Characteristics and prognosis of patients diagnosed with gastric cancer after prior negative gastroscopy, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Lam Y.F., Tong S.M. and Hung I.F.N., Long term rebleeding in patients with obscure gastrointestinal bleeding after first deep enteroscopy, Digestive Disease Week, Orlando, USA. 2013.
Leung W.K., Liu S.K., Tong S.M., Seto W.K.W. and Hung I.F.N., Occult hepatitis B infection in patients with inflammatory bowel disease, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.
Leung W.K., Liu S.H., Seto W.K.W., Chan K.H., Tong S.M. and Hung I.F.N., Prevalence Of Past Or Current Hepatitis B Infection And Factors For Non-vaccination In Chinese Patients With Inflammatory Bowel Diseases, The 1st Meeting of Asian Organization for Crohns’s and Colitis in Tokyo, Japan. 2013.
Leung W.K., Tong D.K.H., Leung S.Y., Chan F.S., Tong S.M., Hung I.F.N., Chu K.M. and Law S.Y.K., Treatment of gastric dysplasia and metaplasia by endoscopic radiofrequency ablation: A feasibility study, Digestive Disease Week, Orlando, USA. 2013.


Researcher : Tse CTA

List of Research Outputs

Chan K.H., Tse C.T.A., Lee J.C.Y. and Lau G.K.K., Weakness that recovers, Grand Round, University Department of Medicine, Faculty of Medicine, The University of Hong Kong. 2012.
Lee J.C.Y., Tse C.T.A., Pang S.Y.Y., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F. and Chan K.H., Central nervous system inflammatory demyelinating disorders in Hong Kong Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 31.


Researcher : Tse EWC

Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:Pin1 modulates the functions of HIF-1 alpha in cancer cells
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2011
Completion Date:12/2012


Project Title:Enhancing the anti-leukaemia effect of arsenic tiroxide by dexamethasone
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012


Project Title:PIN1 and CKS proteins cooperate in the regulation of cell cycle progression
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2013


List of Research Outputs

Chan T.S., Hwang Y.Y., Gill H., Cheung W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital, Intern Med J.. 2012, [Epub ahead of print].
Chan T.S., Hwang Y.Y., Gill H., Cheung W.W.W., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital., Internal Medicine Journal. 2013, 43(5): 541-6.
Cheng C.W., Chow K.M., Pang R.W.C., Fok E.W.S., Kwong Y.L. and Tse E.W.C., PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin., The American Journal of Pathology. 2013, 182(3): 765-775.
Frontini M., Kukalev A., Leo E., Ng Y.M., Cervantes M., Cheng C.W., Holic , Dormann , Tse E.W.C., Pommier Y. and Yu C.C.P.V., The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment, Developmental Cell. 2012, 23(2): 356–370.
Grey W., Izatt L., Sahraoui W., NG Y.M., Ogilvie C., Hulse A., Tse E.W.C., Holic R. and Yu C.C.P.V., Deficiency of the Cyclin-Dependent Kinase Inhibitor, CDKN1B, Results in Overgrowth and Neurodevelopmental Delay, Human Mutation. 2013, 34(6): 864-868.
Kwong Y.L., Kim W.S., Lim S.T., Kim S.J., Tang T., Tse E.W.C., Leung A.Y.H. and Chim J.C.S., SMILE for natural killer (NK)/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group, Blood. 2012, 120(15): 2973-2980.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor., American Journal of Hematology. 2013, 88(6): 485-491.
Leung A.Y.H., Tse E.W.C., Hwang Y.Y., Chan T.S.C., Gill H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Relapses of acute leuekmia after allogeneic hematopoietic stem cell transplantation: second transplantation with reduced intensity conditioning from the original donor, Am J Hematol. 2013, in press.
Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.
Tse E.W.C. and Kwong Y.L., How I treat NK/T-cell lymphomas, Blood. 2013, EPub.
Tse E.W.C. and Kwong Y.L., Practical management of natural killer/T-cell lymphoma, Current Opinion in Oncology. Lippincott Williams & Wilkins, Inc., 2012, 24(5): 480–486.
Tse E.W.C., Gill H., Loong F., Kim S.J., NG S.B., Tang T., Ko Y.H., Chng W.Y., Lim S.T., Kim W.S. and Kwong Y.L., Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group, American Journal of Hematology. 2012, 87(7): 663-8.


Researcher : Tse HF

Project Title:Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):Tse HF, Lau CP, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004


Project Title:Outstanding Researcher Award 2007-2008
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:10/2008


Project Title:Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan FHW, Lam L, Lee KLF, Chan WS, Lam YM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases
Investigator(s):Tse HF, Li RA, Siu DCW, Li GR, Lian Q
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:03/2010
Completion Date:02/2013


Project Title:Autologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy
Investigator(s):Tse HF, Li RA, Siu DCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2010
Completion Date:12/2012


Project Title:Attenuation of Left Ventricular Remodeling and Improvement of Myocardial Function with Spinal Cord Stimulation in Post-myocardial Infarction Heart Failure
Investigator(s):Tse HF, Siu DCW, Wang MM, Yiu KH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2011


Project Title:Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2012


Project Title:Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells
Investigator(s):Tse HF, Ho JCY
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Therapeutic Effects and Mechanism of Sympathorenal Axis Modulation by Catheter-based Renal Denervation in Porcine Model of Ischemic Heart Failure
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


List of Research Outputs

Benda C., Zhou T., Wang X., Tian W., Grillari J., Tse H.F., Grillari-Voglauer R., Pei D. and Esteban M.A., Urine as a source of stem cells. , Adv Biochem Eng Biotechnol. . 2013, 129: 19-32.
Chan K.H., Leung G.K.K., Lau G.K.K., Liu S., Lui W.M., Lau C.P., Tse H.F., Pu J.K.S. and Siu D.C.W., Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage, World Neurosurgery. 2013.
Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
FU Q.L., Chow Y.Y., Sun S.J., Zeng Q.X., Li H.B., Shi J.B., Sun Y.Q., Wen W., Tse H.F., Lian Q. and Xu G., Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Rebalance Th1/th2 And Up-regulate Regulatory T Responses On Peripheral Blood Mononuclear Cells From Allergic Rhinitis Patients, Allergy. Wiley-Blackwell, 2012, Aug 1: doi: 10.1111/j.1398-9995.2012.02875.x..
Guo Y., Chan K.H., Lai K.W.H., Siu D.C.W., Kwan S.C., Tse H.F., Ho W.L. and Ho W.M., Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis , Neuroimmunomodulation. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Lau C.P., Tse H.F., Siu D.C.W. and Gbadebo D., Atrial electrical and structural remodeling: implications for racial differences in atrial fibrillation., In: Eric N. Prystowsky, Journal of Cardiovascular Electrophysiology. Wiley Periodicals, Inc., 2012, 23 Suppl 1: S36-40.
Lau C.P., Gbadebo D.T., Connolly S.J., Van G.E.L.D.E.R. .I.C., Capucci A., Gold M.R., Israel C.W., Morillo C.A., Siu D.C.W., Abe H., Carlson M. and Tse H.F., Ethnic difference in atrial fibrillation identified using implanted cardiac devices., J Cardiovasc Electrophysiology. 2013, 24: 381-387.
Lau C.P. and Tse H.F., Linear ablation for atrial fibrillation guided by acoustic imaging: "How does it sound?" , Heart Rhythm. . 2012, 9: 1863-1864.
Lau C.P., Siu D.C.W. and Tse H.F., Pacing inducibility for atrial fibrillation: A test tested?, J Cardiovasc Electrophysiol. . 2013.
Lau C.P., Tachapong N., Wang C.C., Wang J.F., Abe H., Kong C.W., Liew R., Shin D.G., Padeletti L., Kim Y.H., Omar R., Jirarojanakorn K., Kim Y.M., Chen M.C., Sriratanasathavorn C., Munawar M., Kam R., Chen J.Y., Cho Y.K., Li Y.G., Wu S.L., Bailleul C. and Tse H.F., Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study., Circulation. 2012, 126: 2789.
Lau C.P., Siu D.C.W. and Tse H.F., The future of implications for cardiac rhythm management, Circulation. 2013, 128: 687-93.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.
Li R.A., Ji-Dong Fu J.D.F., Siu D.C.W., Jennifer C. Moore J.M., Deborah K. Lieu D.L., Valeriy Timofeyez V.T., Nipavan Chiamvimonvat N.C., Tse H.F. and Gordon Keller G.K., Identification of a common determinant for the immature properties of derived human cardiomyocytes enables mechanism-based driven maturation, Circulation. . 2012.
Li X., Tse H.F., Yiu K.H., Zhang C. and Jin L., Periodontal therapy decreases serum levels of adipocyte fatty acid-binding protein in systemically healthy subjects: a pilot clinical trial, Journal of Periodontal Research. 2013, 48: 308-314.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Sun Y.Q., Deng M.X., He J., Zeng Q.X., Wen W., Wong D.S., Tse H.F., Xu G., Lian Q., Shi J. and Fu Q.L., Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. , Stem Cells.. 2012, 30: 2692-2699.
Sun Y.Q., Deng M.X., He J., Tse H.F., Lian Q., Shi J. and Fu Q.L., Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice., Stem Cells. 2012, 2692-9.
Tse H.F., Invited Speaker, Asia Pacific Regional Conference, Singapore, “ What difficulties physicians and patients experience when a chronic lead exhibits a failure, and what steps are taken to address the situation”, 2013.
Tse H.F., Chair, Heart Rhythm, Denver, US, “Optimization of CRT using sensor and device diagnostics”, 2013.
Tse H.F., Invited Speaker, AHA 2012, Los Angeles, US, “ CRT Ambulatory Monitoring to Optimize Care”, 2012.
Tse H.F., Invited Speaker, APHRS, Taipei, Taiwan, “Dronedarone in Clinical Practice: Peals and Pitfalls, “Advanced AF Technique, Renal Denervation for Hypertension “Stem Cell for Evaluating and Treating Arrhythmia-Expert meeting, 2012.
Tse H.F., Invited Speaker, ESC Congress 2012, Munich, Germany “ Intermittent versus continuous thoracic spinal cord stimulation for treatment of ischemic heart failure”, 2012.
Tse H.F., Invited Speaker, Meet the Masters, Tokyo, Japan, “ Current Concept of Pharmacological Therapy”, 2012.
Tse H.F., Invited Speaker, Takeda Cardioascular Academy, Osaka, Japan “ Cardiovascular Disease & Hypertension 2012”, 2012.
Tse H.F., Invited Speaker, Asia Go-to-Launch Meeting, Bangkok, Thailand, “ AF Situation in Asia and Unmet Medical Needs, “ Voice of the Experts, overview of warfarin and aspirin safety and efficacy in stroke prevention in NVAF, “ INR & TTR: clinical importance and implications”, 2013.
Tse H.F., Invited Speaker, Biopharma Asia Convention, Singapore “ Applications of IPSC Platform for Diagnosis and treatment of Cardiovascular Diseases”, 2013.
Tse H.F., Invited Speaker, Heart Rhythm, Denver, US, “Spinal Cord Stimulation Core Curriculum 127. Implanted Devices for Autonomic Nervous System Modulation in HF”, 2013.
Tse H.F., Invited Speaker, ODYSSEY Investigator Meeting for Protocol EFC11570, Brisbane, Australia “ Very low LDL-C: Is there reason for concern?, 2013.
Tse H.F., Invited Speaker, Taiwan Society of Cardiology, Taipei, Taiwan “New direction in the development of Anti-arrhythmic drugs” ,” Current, Evolving and Futuristic Therapies for AF” , 2013.
Tse H.F., Invited Speaker, The 5th Ventricular Arrhythmia Symposiuim of China, Nanjing, China “ Benefits of remote monitoring in management of ventricular arrhythmias in patients with device , “Future of device therapy for cardiac arrhythmia”, 2013.
Tse H.F., Invited Speaker, 香山科學會議第454次學術討論會, 杭洲 ”Exome sequencing and induced pluriopotent stem cells for diagnosis and modeling of inherited cardiomyopathy”, 2013.
Tse H.F., Ho J.C.Y., Buter A.W., Lee Y.K., Choi S.W., Ng K.M., Siu D.C.W., Simpson M.A., Lai K.W.H., Chan Y.H., Zhang Y.H., Lay K.W., Esteban M.A., Colman A. and Sham P.C., Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing, Hum Mol Genet . 2013, 22: 1395-1403.
Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
YUNG S.Y.J., WONG K.L., Lau C.S.T., Tse H.F., Tam P.K.H., Garcia-Barcelo M.M. and Ngan E.S.W., Potential use of patient specific induced-pluriopotent stem cell (iPSC) to delineate the molecular pathogenesis of syndromic Hirschsprung (HSCR) , The 11th Annual Meeting of the International Society for Stem Cell Research, Boston, USA 12-15 June 2013.
Yeung C.Y., Lam K.S.L., Li L.S.W., Lam K.F., Tse H.F. and Siu D.C.W., Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia., Diabetes Care. 2012, 35(12): 2564-9.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Yiu K.H., de G.R.A.A.F. .F.R., van V.E.L.Z.E.N. .J.E., Marsan N.A., Roos C.J., Tse H.F., van D.E. .W.A.L.L. .E.E., Schalij M.J., Bax J.J., Schuijf J.D. and Jukema J.W., Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease. , Neth Heart J. . 2013, 21: 347-53.
Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.
Zhao C., Wang M.M., Siu D.C.W., Hou Y.L., Wang T., Tse H.F. and Yiu K.H., Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress , Cardiovasc Diabetol. . 2012, 5:11(1): 147.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.
Zuo M.L., Liu S., Chan K.H., Lau G.K.K., Chong B.H., Lam K.F., Chan Y.H., Lau Y.F., Lip G.Y.H., Lau C.P., Tse H.F. and Siu D.C.W., The CHADS2 and CHA2DS2–VASc scores predict new occurrence of atrial fibrillation and ischemic stroke, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 47-54.


Researcher : Tse HM

List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Kung M.H.W., Zhou Z., Ramsden D.B. and Ho S.L., Synaptic dysfunction implicated in Parkinsonian leucine-rich repeat kinase (LRRK2) R1441G knockin mice, 17th International Congress of Parkinson's Disease and Movement Disorders, June 2013; Sydney, Australia. 2013.
Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.
Lu S., Liu H., Ho W.L., Ho W.M., So H.F., Tse H.M., Kung M.H.W., Ramsden D.B. and Ho S.L., The effect of ex vivo rotenone intoxication on dopamine re-uptake of LRRK2-R1441G mutant mouse, The 18th Medical Research Conference. 2013.
Ramsden D.B., Ho W.L., Ho W.M., Liu H., So H.F., Tse H.M., Chan K.H. and Ho S.L., Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction., Brain and Behavior. 2012, 2(4): 468-478.


Researcher : Tse WW

List of Research Outputs

HO S.K., Yung S.S.Y., Cheung K.F., Tse W.W. and Chan D.T.M., Anti-dsDNA antibodies induce epithelial-to-mesenchymal transition and fibrotic processes in human proximal renal tubular epithelial cells, ASN Kidney Week 2012. 338A.


Researcher : Tso AWK

Project Title:A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2008


Project Title:Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):Tso AWK, Lam KSL, Chan DTM, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2009


List of Research Outputs

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.


Researcher : Tso HW

List of Research Outputs

Tso H.W., He R.J. and Chan C.W.Y., Engineering of the immune system for human ESC- and iPSC-derived grafts, Drug Discovery Today: Disease Models. 2012, 9: e171-178.


Researcher : WANG B

List of Research Outputs

Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.


Researcher : WONG HK

List of Research Outputs

Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wong H.K., Ong K.L., Leung Y.H., Lam T.H., Thomas G.N., Lam K.S.L. and Cheung B.M.Y., A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels, Journal of the Hong Kong College of Cardiology. Presented at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 56.


Researcher : WONG WLD

List of Research Outputs

Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.


Researcher : WU H

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.


Researcher : WU H

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.


Researcher : Wang AYM

Project Title:An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):Wang AYM, Kwan CW, Lai KN
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:07/2008


Project Title:Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):Wang AYM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010




Researcher : Wang J

Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang J.

Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang KLJ

List of Research Outputs

Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Wang K.L.J., Ho J.C.M., Chan J., Mok T., Yee W., Yao T.J., Tam S., Cheung B., Lam W.K., Lam K.S.L., Chan M.M.W. and Ip M.S.M., The effects of inhaled corticosteroids on the risk of diabetes mellitus, prediabetes and glucose regulation in adults with asthma (ICSD Study), Hong Kong Med. J.. 2013, 19 (Suppl. 1): 47.


Researcher : Wang MM

List of Research Outputs

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Zhao C., Wang M.M., Siu D.C.W., Hou Y.L., Wang T., Tse H.F. and Yiu K.H., Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress , Cardiovasc Diabetol. . 2012, 5:11(1): 147.


Researcher : Wang Y

List of Research Outputs

Wang L.P., Wang Y., Zhao L.M., Li G.R. and Deng X.L., Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. , Biochem Pharmacol. 2013, 85(10): 1486-94.
Zhao L.M., Su X.L., Wang Y., Li G.R. and Deng X.L., K(Ca)3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells. , Lab Invest. 2012, 93(2): 159-67.


Researcher : Wong B.C.Y.

Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs



Researcher : Wong BCY

Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

TSE M.K., CHO C.K.L., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAORING-binding domain of XAF1, 6th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.
Tan V.P.Y., Cheung T.K., Wong W.M., Pang R.W.C. and Wong B.C.Y., Treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot study, World Journal of Gastroenterology. 2012, 18(42): 6127-6133.
Tse M.K., Cho L.C.K., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1., Protein Sci.. Wiley, 2012, 21: 1418-1428.
Wong B.C.Y., Management of Gastric Adenocarcinoma in the Asia-Pacific Region – Necessity Drives Differences. , AGA Perspective. 2012.


Researcher : Wong CM

Project Title:Identification of the novel receptors for two liver-derived endocrine Factors FGF21 and adropin
Investigator(s):Wong CM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:The role of beta Klotho in regulation of metabolic homeostasis: Molecular Basis and Physiological Implications
Investigator(s):Wong CM, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2012


Project Title:Deciphering the role of lipocalin 13 in obesity and diabetes: from molecular analysis to physiological relevance
Investigator(s):Wong CM, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Gaur N.A., Hasek J., Brickner D.G., Qiu H., Zhang F., Wong C.M., Malcova I., Vasicova P., Brickner J.H. and Hinnebusch A.G., Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast, Genetics. 2013, 193: 829-851.
Kong K.Y., Tang V.H.M., Huang Z., Hinnebusch A.G., Jin D. and Wong C.M., Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal slicing efficiency, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 13, 2013. 2012.
Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.
Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.


Researcher : Wong DKH

Project Title:Identification of aberrantly methylated CpG loci in hepatitis B virus-related hepatocellular carcinoma
Investigator(s):Wong DKH, Yuen RMF, Lai CL, Fung JYY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:09/2012


Project Title:Application of COLD-PCR sequencing for the early detection of HBV antiviral drug resistant mutations
Investigator(s):Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2010


Project Title:Mutational analysis of the hepatitis B core protein DNA-binding domain and its role in HBV transcription regulation
Investigator(s):Wong DKH, Huang FY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


List of Research Outputs

Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Levels of HBV DNA and not HBsAg are associated with biochemical flares after HBeAg seroconversion, Hepatology International. 2012, 6: 52.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B surfact antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 257.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Reply to Liao et al, Clin Infect Dis. 2013.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serologic and virologic outcomes of tenofovir in Asian chronic hepatitis B patients with prior nucleoside analogue exposure. (Poster presentation at the 63rd) Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 10, 2012, Hepatology. 2012, 56(S1): 415A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Seto W.K.W., Lam Y.F., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen levels during five years entecavir therapy in Asian chronic hepatitis B patients., The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S314.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.
Zheng M.H., Lin X.F., Shi K.Q., You J., Liu W.Y., Lup Y.W., Wong D.K.H., Yuen R.M.F. and Chen Y.P., Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large case-control study, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S555.


Researcher : Wong HK

List of Research Outputs

Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999-2002, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is Human Cytomegalovirus Infection Associated with Hypertension? The United States National Health and Nutrition Examination Survey 1999–2002, Presented at the Seventeenth Research Postgraduate Symposium, University of Hong Kong, Dec 2012.
Li C., Samaranayake N.R., Ong K.L., Wong H.K. and Cheung B.M.Y., Is human cytomegalovirus infection associated with hypertension? The United States national health and nutrition examination survey 1999-2002, PLoS One. 2012, 7 (7): e39760.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wong H.K., Ong K.L., Leung Y.H., Lam T.H., Thomas G.N., Lam K.S.L. and Cheung B.M.Y., A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels, Journal of the Hong Kong College of Cardiology. Presented at the Sixteenth Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong Nov 2012. 20 (2): 56.


Researcher : Wong HYH

List of Research Outputs

Ho W.L., Wong H.Y.H. and Yau T.C.C., The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists?, Acta Ophthalmologica. 2012, Epub on 2012-09-12.
Leung R.C.Y., Lang B.H.H., Wong H.Y.H., Chiu J.W.Y., Wan K.Y., Shek T.W.H., Woo Y.C., Lo C.Y. and Yau T.C.C., Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy, Anti-Cancer Agents in Medicinal Chemistry. 2013, 13(3): 382-388.
Wong H.Y.H. and Yau T.C.C., Management of gastric cancer: The Chinese perspective, Translational Gastrointestinal Cancer. 2012, 1(2): 181-185.
Wong H.Y.H. and Yau T.C.C., Molecular targeted therapies in advanced gastric cancer: does tumor histology matter?, Therapeutic Advances in Gastroenterology. 2013, 6(1): 15-31.
Yau T.C.C., Cheung F.Y., Lee F., Choo S.P., Wong H.Y.H., Toh H.C., Leung A.K., Chan P., Yau T.K., Wong J., Tang Y.F., Lau S.M., Cheung T.T., Fan S.T. and Poon R.T.P., A multicenter phase II study of sorafenib, capecitabine, and oxaliplatin (SECOX) in patients with advanced hepatocellular carcinoma: final results of Hong Kong-Singapore Hepatocellular Carcinoma Research Collaborative Group study, The American Society of Clinical Oncology Annual Meeting, Chicago, U.S.A., 31 May - 4 June 2013. Abstract 4117.


Researcher : Wong KY

Project Title:Epigenetic regulation of tumour suppressor miR-33b in multiple myeloma
Investigator(s):Wong KY, Chim JCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2013


Project Title:Chromatin and Epigenetics in Cancer; Epigenetic inactivation of the MIR129-2 in hematological malignancies
Investigator(s):Wong KY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


List of Research Outputs

Wong K.Y., Yim R.L.H., Kwong Y.L., Leung C.Y., Hui P.K., Cheung F., Liang R.H.S., Jin D.Y. and Chim J.C.S., Epigenetic inactivation of the MIR129-2 in hematological malignancies, J Hematol Oncol. 2013, 6:16.
Wong K.Y., Frontiers in Epigenomics. Frontiers Research Foundation, 2012.
Yim R.L.H., Kwong Y.L., Wong K.Y. and Chim J.C.S., DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas, Frontiers in non-coding RNA. 2012, 2:233.


Researcher : Wong KYM

List of Research Outputs

Tam C.C.T., Ho J.C.M., Wong K.Y.M., Wong W.M., Wang K.L.J., Lam C.M.J., Lui M.S.M., Lam W.K., Ip M.S.M. and Lam C.L.D., Treatment outcomes in elderly with advanced-stage non-small celllung cancer. 17th Congress of the Asia Pacific Society of Respiroogy, Hong Kong , Respirology. 2012, 17(Suppl 2): 100 (Abstract 473).
Wong K.Y.M., Lam C.L.D., Ip M.S.M. and Ho J.C.M., EBUS-TBNA gives adequate tissue information on cell type in lung cancer, Hong Kong Med.J.. 2013, 19 (Suppl. 1): 51.
Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.


Researcher : Wong LY

List of Research Outputs

Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.


Researcher : Wong LYF

Project Title:Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Wong RWS

List of Research Outputs

Li P.H., Wong W.H.S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Tong K.L., Tse N.K.C., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chong C.Y., Wong R.W.S., Mok T.M.Y., Ying S.K.Y., Fung S.K.S., Lai W.M., Yang W. and Lau Y.L., Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese, Rheumatology. Oxford, 2013, 52(2): 337-345.
Yang W., Tang H., Zhang Y., Tang X., ZHANG J., Sun L., Yang J., Cui Y., Zhang L., Hirankarn N., Cheng H., Pan H.F., Gao J., Lee T.L., Sheng Y., Lau W.C.S., Li Y., Chan T.M., Yin X., Ying D., Lu Q., Leung A.M.H., Zuo X., Chen X., Tong K.L., Zhou F., Diao Q., Tse N.K.C., Xie H., Mok C.C., Hao F., Wong S.N., Shi B., Lee K.W., Hui Y., Ho M.H.K., Liang B., Lee P.P.W., Cui H., Guo Q., Chung B.H.Y., Pu X., Liu Q., Zhang X., Zhang C., Chong C.Y., Fang H., Wong R.W.S., Sun Y., Mok T.M.Y., Li X.P., Avihingsanon Y., Zhi Z., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Gao F., Shotelersuk V., Kang X., Ying S.K.Y., Zhang L., Wong W.H.S., Zhu D., Fung S.K.S., Zeng F., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Shen N., Tam P.K.H., Sham P.C., Ye D.Q., Yang S., Zhang X. and Lau Y.L., Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians, The American Journal of Human Genetics. 2013, 92: 41-51.
Zhang J., Zhang Y., Zhang L., Yang J., Ying D., Zeng S., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Lau Y.L. and Yang W., Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients, Annals of Human Genetics. 2013, 77(4): 344-350.


Researcher : Wong SY

List of Research Outputs

Hung I.F.N., Leung W.K., Liu K., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tan V.P.Y. and Wong S.Y., A prospective randomized trial with 7-day nitrofurantoin-moxifloxacin containing regime for highly resistant Helicobacter pylori infection, United European Gastroenterology Week, Amsterdam, Netherlands. 2012.


Researcher : Wong Y

List of Research Outputs

Lam K.Y.J., Wong Y., Shiu S.W.M., Betteridge D.J. and Tan K.C.B., Effect of insulin on the soluble receptor for advanced glycation end products (RAGE)., Diabetic Medicine. UK, Wiley, 2013, 30: 702-709.
Lam K.Y.J., Wang Y., Shiu S.W.M., Wong Y. and Tan K.C.B., Soluble receptor for advanced glycation end-products in Chinese Type 1 diabetic patients., The 9th International Diabetes Federation Western pacific Region Congress, Kyoto, Japan. 2012.
Shiu S.W.M., Wong Y. and Tan K.C.B., Effect of advanced glycation end products on letin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells., J Atheroscler Thromb. 2012, 19(12): 1083-92.
TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.
Tan K.C.B., Shiu S.W.M. and Wong Y., Advanced glycation endproducts induce lectin-like oxidized lipoprotein receptor-1 expression via mammalian target of rapamycin. , The International Diabetes Federation 21st World Diabetes Congress, Dec 2011, Dubai.. 2012.


Researcher : Wong YK

List of Research Outputs

Fung M.C.F., Fung F.H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Prognosis after Status Epilepticus, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013 . 2013.
Kwok H.M., Tsui H.L., Wong W.Y., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, clinical characteristics and prognostic factors of Guillain-Barre syndrome in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 25.
Kwok K.H.M., Tsui K.H.L., Wong D.W.Y., Wong Y.K., Chang S.K.R., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Variants, Clinical Characteristics and Prognostic Factors of Guillain Barré Syndrome in Chinese, 65th American Academy of Neurology Annual Meeting, San Diego, USA, March 16-23, 2013.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Hon F.K.S., Chan K.H., Mak W., Tse H.F., Siu D.C.W., Cheung R.T.F., Ho S.L. and Li L.S.W., Prognosis and functional outcome after ischaemic stroke in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Yeung C.F., Fung H.F., Wong Y.K., Chang S.K.R., Mak W., Hon F.K.S., Cheung R.T.F., Ho S.L., Chan K.H. and Lau G.K.K., Clinical features, management, and prognostic factors of status epilepticus in Chinese, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.


Researcher : Wong YL

List of Research Outputs

Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.


Researcher : Woo YC

List of Research Outputs

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Leung R.C.Y., Lang B.H.H., Wong H.Y.H., Chiu J.W.Y., Wan K.Y., Shek T.W.H., Woo Y.C., Lo C.Y. and Yau T.C.C., Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy, Anti-Cancer Agents in Medicinal Chemistry. 2013, 13(3): 382-388.
Loong H.N.C., Woo Y.C., Leung L.Y.E., Lam K.Y.J. and Tan K.C.B., Risk factors related to Chinese population with fracture., 3rd Asia-Pacific Osteoporosis Meeting, Kuala Lumpur, Malaysia.. 2012.
Woo Y.C., Xu A., Wang Y. and Lam K.S.L., Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives, Clin Endocrinol (Oxf). 2012, 78: 489-496.


Researcher : Wu H

List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012.
WU H., LUK T.W., LAM K.Y.I., Lau W.C.S., Chan W.K. and Mok T.M.Y., Lupus monocyte-derived dendritic cells treated with 1α,25-dihydroxyvitamin D3 and dexamethasone are tolerogenic and induce IL-10 producing regulatory T cells, Presented at the European League Against Rheumatism Congress, Madrid, June 12-15, 2013. Annals of Rheumatic Disease 2013. 72 (Suppls3): 825.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.


Researcher : Wu W

List of Research Outputs

Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Wu W., Sun H., Deng X.L. and Li G.R., EGFR Tyrosine kinase regulates small conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK 293 cells, Biochem J. 2013, 452(1): 121-129.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.


Researcher : XIE B

List of Research Outputs

XIE B., ZHANG M., Mak H.K.F. and Cheung R.T.F., Blood pressure variability and silent small vessel cerebrovascular lesions in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 534.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Junior Investigator's Award for poster, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 22: 239.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Lack of association between brachial-ankle pulse wave velocity and white matter hyperintensities in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 239.


Researcher : Xia HHX

Project Title:Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


Project Title:Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2005




Researcher : Xiao S

Project Title:Replication and Functional Study of Polymorphisms in miRNA Binding Sites and Osteoporosis
Investigator(s):Xiao S, Kung AWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:02/2011
Completion Date:08/2012


List of Research Outputs

Xiao S., Gao R.Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk., Osteoporosis International. 2012, 23(7): 1877-87.


Researcher : Xiong J

Project Title:2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):Xiong J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2008




Researcher : Xu A

Project Title:Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2007


Project Title:Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
Investigator(s):Xu A, Lam KSL, Vanhoutte PMGR, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2008


Project Title:Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2012


Project Title:APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2011


Project Title:71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2011


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Vanhoutte PMGR, Wang Y, Lam KSL
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2011


Project Title:The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:The Ubiquitin Ligase Mdm2 as a Novel Regulator of Adipose Functions and Obesity
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:EDHF 2012 ENDOTHELIUM-SELECTIVE ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE IMPROVES RE-ENDOTHELIALIZATION AND VASCULAR FUNCTION VIA INDUCTION OF HEME OXYGENASE-1 IN DIABETIC MICE
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


Project Title:The adaptor protein APPL1 as a physiological regulator of insulin secretion in pancreatic ?cells
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:CPT1a as a novel mediator of diabetes-induced oxidative stress and endothelial dysfunction: Mechanisms and physiological implications
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


List of Research Outputs

Alkharfy K.M., Al-Daghri N.M., Vanhoutte P.M.G.R., Krishnaswamy S. and Xu A., Serum Retinol-Binding Protein 4 as a Marker for Cardiovascular Disease in Women, PLOS ONE. 2012, 7: 1-8.
Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.
Cao M., Mao Z., Kam C., Xiao N., Cao X., Shen C., Cheng K.Y., Xu A., Lee K.M., Jiang L. and Xia J., Pick1 and ica69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. , PLOS Biology. 2013, 11(4).
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.
Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.
Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
Chen J., Xu A., Liu J., Lam K.S.L. and Wang Y., Adipose-derived Stromal Cells Derived from Adiponectin Deficient Mice Promote the Development of Metaplastic Mammary Tumors, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 67.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 promotes insulin secretion by up-regulating expression of exoytotic SNARE proteins via Akt dependent pathway in mice. , 7 th International Huaxia Congressof Endocrinology 2012.
Cheng K.Y., Lam K.S.L., Wu D. and Xu A., APPL1 regulates insulin secretion in pancreatic beta cells. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.
Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Dong J., Wong S.L., Lau C.W., Liu J., Wang Y., He Z.D., Ng C.F., Chen Z.Y., Yao X., Xu A., Ni X., Wang H. and Huang Y., Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor, Kidney international. 2013, 84: 54-63.
Fan P., Berger T., Xu A., Mak T.W. and Wang Y., Lipocalin-2 Acts as a Stromal Factor to Promote Mammary Carcinogenesis by Activating Phospholipase A2 in Breast Cancer Cells, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 164.
Fang Q., Li H., Song Q., Yang W., Hou X., Ma X., Lu J., Xu A. and Jia W., Serum fibroblast growth factor 19 levels are decreased in chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels, Diabetes Care. 2013, Epub [2013 Apr 29].
Gu P. and Xu A., Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction, In: Zhenqi Liu, Rev Endocr Metab Disord. US, Springer US, 2013, 14: 49-58.
Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.
Hoo R.L.C., Lee P.C., Zhou M., Wong Y.L., Hui X., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice, J Hepatol. 2013, 58(2): 358-64.
Hui X., Lam K.S.L. and Xu A., Adipose selective disruption of SIRT1 impairs insulin sensitivity via modulation of macrophage infiltration and polarization, Immunometabolism: From mechanism to therapeutic application. 2013.
Hui Y.L.E., Xu A., Yang H.B. and Lam K.S.L., Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines, Journal of Diabetes Investigation. 2013, 4: 413-425.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Jia W., Xu A., Chen A., Wu J. and Ye J., Chronic vascular complications in diabetes, Journal of diabetes research. 2013, 2013: 858746.
Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.
LI H., Wang T., Lei S., Ng J.K.F., Irwin M.G., Xu A. and Xia Z., Adiponectin Restores Diabetic Heart Sensitivity to Ischemic Posctconditioning: Role of STAT3 Activation, FASEB J. 2013, 27: 1169.10.
LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4, Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, 33: 777-784.
LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing nadph oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol. 2013, 33: 777-784.
Lam K.S.L., Hoo R.L.C., LEE P.C. and Xu A., A-FABP deficiency protects against diet induced steatohepatitis in mice, 95th Endocrine Society Annual Meeting and Expo. 2013.
Li D., Tsang J.Y.S., Peng J., HO H.H., CHAN Y.K., Zhu J., Lui V.C.H., Xu A., Lamb J.R., Tam P.K.H., Chen Y. and Chen Y., Adiponectin mediated MHC Class II mismatched cardiac graft rejection in mice is IL-4 dependent, PLoS One. 2012, 7(11): e48893.
Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.
Li F.Y.L., Lam K.S.L. and Xu A., Therapeutic perspectives for adiponectin: An update, Curr Med Chem. 2012, 19(32): 5513-23.
Li F.Y.L., Baretella O., Tang E.H.C., Vanhoutte P.M., Lam K.S.L., Chung S.K. and Xu A., Tie-1dependent endothelial cell restricted over-expression of endothelin-1 paradoxically impairs vascular contractions response to serotonin, ET-12 meeting, London, 2012.
Li H., Dong K., Fang Q., Hou X., Zhou M., Bao Y., Xiang K., Xu A. and Jia W., High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in china., Journal of Hepatology. 2012, 58: 557-563.
Li X., Cheng K.Y., Chen C., WANG B., Lam K.S.L. and Xu A., MDM2 inhibitor nutlin-3a impairs glucose homeostasis and insulin secretion in mice. , 18th Medical Research Conference 2011. The University of Hong Kong. 2013.. 2013.
Lin Z., Tian H., Lam K.S.L., Lin S., Hoo R.L.C., Konishi M., Itoh N., Wang Y., Bomstein S.R., Xu A. and Li X., Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice, Cell Metabl . 2013, 17: 779-789.
Liu L., Liu J., Wong W.T., Tian X.Y., Lau C.W., Wang Y.X., Xu G., Pu Y., Zhu Z., Xu A., Lam K.S.L., Chen Z.Y., Ng C.F., Yao X. and Huang Y., Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension through GLP-1 Dependent Mechanism, Hypertension . 2012, 60(3): 833-41.
Liu M., Zhou M., Bao Y., Xu Z., Li H., Zhang H., Zhu W., Zhang J., Xu A. and Jia W., Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure, Clin Sci (Lond). 2012, 124: 115-122.
Liu Y., Turdi S., Park T., Morris N.J., Deshaies Y., Xu A. and Sweeney G., Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis, Diabetes. 2012, 62: 743-752.
Nie T., Hui X. and Xu A., Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function, FEBS Letter. 2012.
Ong K.L., Rye A., O'Connell R., Jenkins A., Brown C., Xu A., Sullivan D.R., Barter P.J. and Keech A.C., Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes, J Clin Endocrinol Metab. 2012, 97: 4701-4708.
Vu V., Liu Y., Sen S., Xu A. and Sweeney G., Delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubbles improves insulin sensitivity and whole body glucose homeostasis, Am J Physiol Endocrinol Metab. 2012, 304: E168-175.
Vu V., Bui P., Eguchi M., Xu A. and Sweeney G., Globular adiponectin induces lkb1/ampk-dependent glucose uptake via actin cytoskeleton remodeling, J Mol Endocrinol. 2013, 51: 155-165.
WONG H.K., Ong K.L., Leung Y.H., Cheung T.T., Xu A., Lam T.H., Lam K.S.L. and Cheung B.M.Y., Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene, PLoS One.. 2013, 8: e70335.
Wang T., MAO X., LI H., Qiao S., Xu A., Wang J., Lei S., LIU Z., Ng K., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol up-regulated the jak/stat3 and pi3k/akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes, Free Radic Biol Med. 2013, 63: 291-303.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and chronic liver diseases: an update, Adiponectin: Production, Regulation and Roles in Disease. Nova Science, 2012.
Woo Y.C., Xu A., Wang Y. and Lam K.S.L., Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives, Clin Endocrinol (Oxf). 2012, 78: 489-496.
Xiao Y., Xu A., Hui X., Zhou P., Li X., Zhong H., Tang W., Huang G. and Zhou Z., Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes., Immunometabolism: from mechanisms to therapeutic applications. PLOS, 2013, 8: e66607.
Xu A., APPL1 as a common adaptor of both adiponectin and insulin signaling, The 64th FUJIHARA Seminar: International Symposium on adiponectin Biology and Medicine. Tomakomai, Japan. 2012.
Xu A., Adiponectin and FGF21 act in concert to combat obesity-related medical complications, The 8th Xiangya International Symposium on Diabetes and Immunology, Changsha, China. 2013.
Xu A., Adiponectin and endothelia repair: mechanism and clinical implications, The 5th Asia Vascular Biology Meeting, Xi’an, China . 2012.
Xu A., Cross talk between perivascular adipose tissue and blood vessels in obesity-related metabolic and vascular diseases, The 2013 submit on NAFLD and Lipid Metabolism of Fudan--‐Zhongshan Hospital, Shanghai China . 2013.
Xu A., The adaptor protein APPL1 as an integrator of insulin signaling and insulin secretion, The 5th National Forum on New Technologies in Drug Discovery, Shanghai, China. 2013.
Xu A., The protective effects of adiponectin against diabetic complications, The 7th International Xuaxia congress of endocrinology, Hong Kong . 2012.
Xu A., Vascular Protective Effects of Adiponectin: an update , The 6th forum of Shanghai Jiaotong University on Diabetes and diabetic complications; Shanghai, China. 2013.
Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.
Xu G., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, Journal of Biological Chemistry. 2012, 287: 4808-17.
Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.Y., Li X. and Xu A., Toll-like receptor-4 mediated obesity-induced nonalcoholic steatohepatitis through activation on X-box binding protein-1 in mice, Gut. 2012, 61(7): 1058-67.
Ye H., Zhang J., Xu A. and Hoo R.L.C., Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone, PLoS One. 2013, 8: e65543.
Yuen C.Y., Wong S.L., Lau C.W., Tsang S.Y., Xu A., Zhu Z., Ng C.F., Yao X., Kong S.K., Lee H.K. and Huang Y., From Skeleton to Cytoskeleton: Osteocalcin Transforms Vascular Fibroblasts to Myofibroblasts Via Angiotensin II and Toll-Like Receptor 4, Circ Res. 2012, 111(3): e55-66.
Zhang J., To K.K.W., LI C., Lau C.Y., Poon K.M., Chan C.S., Zheng B., Hung I.F.N., Lam K.S.L., Xu A. and Yuen K.Y., Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A (H1N1) Infection Associated with Cytokine Dysregulation in Mice with Diet-Induced Obesity, Journal of Infectious Diseases. 2013, 207(8): 1270-80.


Researcher : Xu J

Project Title:Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese
Investigator(s):Xu J, Lam KSL, Sham PC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004




Researcher : Yam IYL

List of Research Outputs

Yam I.Y.L., Lam C.L.D., Chan K., Ho J.C.M., Ip M.S.M., Lam W.K., Chan T.K. and Chan V.N.Y., EGFR Array: Uses in the Detection of Plasma EGFR Mutations in Non-small Cell Lung Cancer Patients, Journal of Thoracic Oncology. 2012, 7 (7): 1131 - 1140.


Researcher : Yan G

List of Research Outputs

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.


Researcher : Yang M

Project Title:Protective effect of thrombopoietin on iron-induced cardiomyopathy
Investigator(s):Yang M
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Children's Thalassaemia Foundation - General Awards
Start Date:07/2007


Project Title:The effect of melatonin in the treatment of thrombocytopenia
Investigator(s):Yang M
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:01/2008


Project Title:The protective effects of thrombopoietin and amlodipine on iron overload-induced human mesenchymal stem cell damage: its impact on iron overload related osteopenia & osteoporosis
Investigator(s):Yang M, Chan GCF, Cheung YF, Liu C
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Children's Thalassaemia Foundation - General Awards
Start Date:01/2009


List of Research Outputs

Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.


Researcher : Yap YHD

Project Title:American Society of Nephrology Kidney Week 2012; Outcome of long-term treatment with mycophenolate mofetil in patients with severe lupus nephritis
Investigator(s):Yap YHD
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:The effect of activated T lymphocytes on cytokine secretion in renal proximal tubular epithelial cells - implications in lupus nephritis
Investigator(s):Yap YHD, Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2013


List of Research Outputs

Chan D.T.M., Cheung K.F., Yim A.S.Y., Yap Y.H.D. and Yung S.S.Y., Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis, Journal of the American Society of Nephrology. 2012, 23: 567A.
Chan T.C., Yap Y.H.D., Shea Y.F., Luk K.H., Chan H.W. and Chu L.W., Prevalence and associated comorbidities of moderate to severe chronic renal impairment in chinese nursing home older adults., J Am Med Dir Assoc. 2012, 13: 630-3.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chu L.W. and Chan F.H.W., Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study, Journal of the American Medical Directors Association. 2012, 13(9): 782-7.
Chan T.C.I., Yap Y.H.D., Shea Y.F., Luk J.K.H., Chan F.H.W. and Chu L.W., Prevalence of anemia in Chinese nursing home older adults: Implication of age and renal impairment [Epub ahead of print], Geriatrics & Gerontology International. 2012.
Choy B.Y., Lam M.F., Yip T., Tang H.L., Wong P.N., Chow C.C., Yap Y.H.D. and Chan D.T.M., Dosing Regimen and Tolerability of Methoxy Polyethylene Glycol-Epoetin Beta in Chinese Dialysis Patients, Nephrology (Carlton). 2013.
Kwan L.P., Choy C.B.Y., Chan D.T.M., Suen W.S. and Yap Y.H.D., Successful treatment of pulmonary rhizopus infection with surgical resection and posaconazole in a renal transplant recipient, Nephrology (Carlton). 2013, 18(1): 74-5.
Ma K.M.M., Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Charlson Co-morbidity Index and albumin significantly associated with fracture risk in peritoneal dialysis patients , Nephrology (Carlton). 2013, 18(5): 365-368.
Ma K.M.M., Yap Y.H.D., Yip K.Y.P., Lui S.L. and Lo W.K., Staphylococcus aureus peritonitis in two peritoneal dialysis patients: an uncommon complication of peripheral intravenous catheter infection, Peritoneal Dialysis International. 2012, 32(5): 573-4.
Ma M.K.M., Yap Y.H.D., Lui S.L. and Lo W.K., Impaired Chronotropic Response Limits Exercise Tolerance in Peritoneal Dialysis and Renal Transplant Patients, American Society of Nephrology Kidney Week 2012.
Tang S.C.W., Yap Y.H.D. and Ma M.K.M., Prospective Randomized Trial of Effect of Direct Renin Inhibition in Non-Diabetic Chronic Kidney Disease (DRINK): An Interim Analysis, American Society of Nephrology. 2012.
Yap Y.H.D., Kwan L.P., To K.K.W. and Chan D.T.M., Arcobacter peritonitis after fluoroscopic repositioning of a Tenckhoff catheter, Peritoneal Dialysis International. 2013, 33(2): 222-3.
Yap Y.H.D., Chan G.C.W., Mok M.M. and Chan D.T.M., Epistaxis in a kidney transplant recipient - an uncommon presentation of post-transplant lymphoproliferative disease [Epub ahead of print], Nephrology (Carlton). 2013.
Yap Y.H.D., Importance of End-Organ-Protection to Hypertensive Patients with Nephropathy, Association of General Practitioners in Macau. 2012.
Yap Y.H.D., Li Shu Pui Medical Foundation Clinical Fellowship, Li Shu Pui Medical Foundation Clinical Fellowship Scheme The University of Hong Kong. 2012.
Yap Y.H.D., Ma K.M.M., Mok M.M., Tang S.O.C. and Chan D.T.M., Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis, Rheumatology (Oxford). 2013, 52(3): 480-6.
Yap Y.H.D., New Concern in CKD patients - Lipid Management, Continuous Medical Education Program, Hong Kong Baptist Hospital. 2013.
Yap Y.H.D., Ma M.K.M. and Chan D.T.M., Outcome of Long-Term Treatment with Mycophenolate Mofetil in Patients with Severe Lupus Nephritis, American Society of Nephrology Kidney Week 2012.
Yap Y.H.D., Ma K.M.M., Yip T.P.S., Lui S.L. and Lo W.K., Peritoneal dialysis-related peritonitis caused by erosion of umbilical abscess into the peritoneal cavity, Peritoneal Dialysis International. 2012, 32(4): 483-4.
Yap Y.H.D., Ma M.K., Tang C.S. and Chan D.T.M., Proliferation Signal Inhibitors (PSI) in the Treatment of Lupus Nephritis - Preliminary Experience., Nephrology (Carlton). 2012.
Yap Y.H.D., Renal Physiology, Acute Renal Failure & Management, Principles of Dialysis & Continuous Renal Replacement Therapy, HA Institute of Advanced Nursing Studies & HKWC. 2012.
Yap Y.H.D., Tang C.S., Ma M.K., Lam M.F. and Chan D.T.M., Survival Analysis and causes of mortality in patients with lupus nephritis, Nephrol. Dial. Transplant.. 2012, 27: 3248-54.
Yap Y.H.D., Ma M.K.M., Mok M.M.Y., Kwan L.P.Y., Chan G.C.W. and Chan D.T.M., The impact of corticosteroids and mycophenolate mofetil treatment on the serum immunoglobulin levels in lupus nephritis patients, World Congress of Nephrology 2013.
Yap Y.H.D. and Lai K.N., The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedside, Nephrology (Carlton). 2013, 18(4): 243-55.


Researcher : Yau TCC

Project Title:The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:A Pilot Study to Evaluate the Prophylactic Effects of Telbivudine for Prevention of Hepatitis B Reactivation in HBsAg Positive Patients Receiving Sorafenib Treatment for Advanced Hepatocellular Carcinoma
Investigator(s):Yau TCC, Poon RTP
Department:Surgery
Source(s) of Funding:Small Project Funding
Start Date:06/2012


Project Title:4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases
Investigator(s):Yau TCC
Department:Surgery
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2013


Project Title:The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients
Investigator(s):Yau TCC, Poon RTP
Department:Surgery
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Ho W.L., Wong H.Y.H. and Yau T.C.C., The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists?, Acta Ophthalmologica. 2012, Epub on 2012-09-12.
Shea Y.F., Chiu J.W.Y., Mok M.Y., Hung I.F.N. and Yau T.C.C., Sunitinib-induced hyperammonaemia in a patient with pancreatic neuroendocrine tumour, Journal of Clinical Pharmacy and Therapeutics. 2013.
Wong H.Y.H. and Yau T.C.C., Management of gastric cancer: The Chinese perspective, Translational Gastrointestinal Cancer. 2012, 1(2): 181-185.


Researcher : Ye D

Project Title:Role of lipocalin-2 in nonalcoholic fatty liver disease
Investigator(s):Ye D, Wang Y
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


List of Research Outputs

Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.Y., Li X. and Xu A., Toll-like receptor-4 mediated obesity-induced nonalcoholic steatohepatitis through activation on X-box binding protein-1 in mice, Gut. 2012, 61(7): 1058-67.


Researcher : Yeung CK

Project Title:HLA-B* 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong
Investigator(s):Yeung CK, Tang SCW, Cheung BMY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2012


List of Research Outputs

Chan J.F.W., Trendell-Smith N.J., Chan C.Y.J., Hung I.F.N., Tang B.S.F., Cheng V.C.C., Yeung C.K. and Yuen K.Y., Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond, Dermatology 2013. 2013, 226: 157-166.
Chiu M.L.S., Hu M., Ng M.H.L., Yeung C.K., Chan C.Y.J., Chang M.M., Cheng S.H., Li L. and Tomlinson B., Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong, British Journal of Dermatology. 2012, 167(1): 44-49.
Lam M.P.S., Yeung C.K. and Cheung B.M.Y., Pharmacogenetics of Allopurinol-Making an Old Drug Safer, The Journal of Clinical Pharmacology. 2013, 53(7): 675-679.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.


Researcher : Yeung CY

List of Research Outputs

Chow W.S., Tso A.W.K., Xu A., Yuen M.M.A., Fong H.Y., Lam T.H., Lo S.V., Tse H.F., Woo Y.C., Yeung C.Y., Cheung B.M.Y. and Lam K.S.L., Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: A 12-year prospective study, J Am Heart Association. 2013, 2(1): e004176.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The 73rd Scientific Sessions of American Diabetes Association, 21-25 Jun 2013, Chicago, USA. 2013.
Hui Y.L.E., Lam T.H., Chow W.S., Yeung C.Y., Woo Y.C., Fong H.Y., Xu A., Tse H.F., Cheung B.M.Y. and Lam K.S.L., Plasma fibrinogen level as a predictor of cardiovascular diseases, independent of diabetes, in a population-based 16-year prospective study in Hong Kong, The American Diabetes Association's 73td Scientific Sessions. 2013.
Lau G.K.K., Chan Y.H., Liu S., Chan K.H., Yeung C.Y., Ho S.L., Lau C.P., Li L.S.W., Tse H.F. and Siu D.C.W., Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Yeung C.Y., Lam K.S.L., Li L.S.W., Lam K.F., Tse H.F. and Siu D.C.W., Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia., Diabetes Care. 2012, 35(12): 2564-9.


Researcher : Yeung SC

List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.
LAU K.W., LI X., Yeung S.C., CHAN K.H., Ip M.S.M. and Mak J.C.W., The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo, Free Radic. Res.. 2012, 46: 1413-1419.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, 17th Congress of the Asian Pacific Society of Respirology (APSR) . Respirology, 2012, 17 (Suppl. 2): 50.
LIANG Y., Yeung S.C., Ip M.S.M. and Mak J.C.W., Cigarette smoke induces differential alteration of AMP-activated protein kinase (AMPK) in rat heart, Respirology. 2012, 17 (Suppl. 2): 50.
Mak J.C.W., Chu J.L., Yeung S.C., Chan M.M.W. and Ip M.S.M., Elevated plasma levels of growth differentiation factor (GDF)-15 in stable chronic obstructive pulmonary disease (COPD), Am. J. Respir. Crit. Care Med.. 2013, 187: A1526.


Researcher : Yim ASY

List of Research Outputs

Chan D.T.M., Cheung K.F., Yim A.S.Y., Yap Y.H.D. and Yung S.S.Y., Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis, Journal of the American Society of Nephrology. 2012, 23: 567A.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin Suppresses Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of PKC-alpha Phosphorylation, Peritoneal Dialysis International . 2012, 32: S120.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin suppresses fibrotic processes in human peritoneal mesothelial cells through inhibition of PKC-alpha phosphorylation, 14th Congress of the International Society for Peritoneal Dialysis, Kuala Lumpur, Malaysia. 2012.
Lui S.L., Yung S.S.Y., Yim A.S.Y., Wong K.M., Tong K.L., Wong K.S., Li C.S., Au T.C., Lo W.K., Ho Y.W., Ng F., Tang S.O.C. and Chan D.T.M., A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport, and Inflammation Markers: A Randomized Clinical Trial, American Journal of Kidney Diseases. 2012, In press.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.


Researcher : Yim RLH

List of Research Outputs

Wong K.Y., Yim R.L.H., Kwong Y.L., Leung C.Y., Hui P.K., Cheung F., Liang R.H.S., Jin D.Y. and Chim J.C.S., Epigenetic inactivation of the MIR129-2 in hematological malignancies, J Hematol Oncol. 2013, 6:16.
Yim R.L.H., Kwong Y.L., Wong K.Y. and Chim J.C.S., DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas, Frontiers in non-coding RNA. 2012, 2:233.
Yim R.L.H., Lee T.Y., Vavken P. and Samartzis D., The safety and efficacy of mesenchymal stem cells for prevention or regeneration of intervertebral disc degeneration: a systematic review, 40th Annual Meeting of the International Society for the Study of the Lumbar Spine. Phoenix, Arizona, 2013.
Yim R.L.H., Lee T.Y., Leung Y.L., Cheung K.M.C., Vavken P. and Samartzis D., The safety and efficacy of mesenchymal stem cells for prevention or regeneration of intervertebral disc degeneration: a systematic review, Global Spine Congress. Hong Kong, 2013.


Researcher : Yip KYP

List of Research Outputs

Ma K.M.M., Yap Y.H.D., Yip K.Y.P., Lui S.L. and Lo W.K., Staphylococcus aureus peritonitis in two peritoneal dialysis patients: an uncommon complication of peripheral intravenous catheter infection, Peritoneal Dialysis International. 2012, 32(5): 573-4.


Researcher : Yip TPS

List of Research Outputs

Ma K.M.M., Yap Y.H.D., Yip T.P.S., Lui S.L. and Lo W.K., Charlson Co-morbidity Index and albumin significantly associated with fracture risk in peritoneal dialysis patients , Nephrology (Carlton). 2013, 18(5): 365-368.
Yap Y.H.D., Ma K.M.M., Yip T.P.S., Lui S.L. and Lo W.K., Peritoneal dialysis-related peritonitis caused by erosion of umbilical abscess into the peritoneal cavity, Peritoneal Dialysis International. 2012, 32(4): 483-4.


Researcher : Yiu KH

Project Title:Mechanism and Reversibility of Myocardial Fibrosis in Patients with Diabetic Cardiomyopathy: Role of Aliskiren.
Investigator(s):Yiu KH, Lam KSL, Tse HF, Wang MM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


List of Research Outputs

Chan Y.H., Lau G.K.K., Yiu K.H., Yiu Y.F., Li L.S.W., Lam T.H., Lau C.P., Siu D.C.W. and Tse H.F., PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013.
Chan Y.H., Siu D.C.W., Yiu K.H., Yiu Y.F., Lau G.K.K., Lam T.H., Lau C.P. and Tse H.F., Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients, Journal of Interventional Cardiac Electrophysiology. 2013, 37: 55-61.
JIM M.H., TSUI K.L., CHEUNG G.S., Siu D.C.W., Ho H.H., Chow W.H., LI S.K. and Yiu K.H., Jeopardised Inferior Myocardium (JIM) Score: An Arithmetic Electrocardiographic Score to Predict the Infarct-Related Artery in Inferior Myocardial Infarction., Annals Academy Medicine Singapore. 2012, 41(7): 300-4.
Lau G.K.K., Chan Y.H., Wong Y.K., Yiu K.H., Teo K.C., Li L.S.W., Shu X.O., Cheung R.T.F., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Garlic intake is an independent predictor of endothelial function in patients with ischaemic stroke, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 29.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes, Cardiovascular Diabetology. 2012, 11: 101.
Lau G.K.K., Wong Y.K., Chan Y.H., Yiu K.H., Teo K.C., Li L.S.W., Ho S.L., Chan K.H., Siu D.C.W. and Tse H.F., Prognostic implications of surrogate markers of atherosclerosis in low-to-intermediate risk patients with type 2 diabetes, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013, 19 (Suppl 1): 30.
Li X., Tse H.F., Yiu K.H., Zhang C. and Jin L., Periodontal therapy decreases serum levels of adipocyte fatty acid-binding protein in systemically healthy subjects: a pilot clinical trial, Journal of Periodontal Research. 2013, 48: 308-314.
Luk T.H., Dai Y.L., Siu D.C.W., Yiu K.H., CHAN H.T., Lee S.W.L., Li L.S.W., Fong B., Wong W.K., Tam S., Lau C.P. and Tse H.F., Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial., Eur J Cardiovasc Prev Rehabil.. 2012, 19: 830-9.
Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatol Curr Res. 2013, S5: 002.
Wu M., Zeng F.F., Wang R., Seto W.K.W., Pai M.C.P., Chu P.C.M. and Yiu K.H., Atherosclerosis in patients with rheumatoid arthritis, Rheumatology: Current Research. OMICS Publishing Group, 2013, S5: 002.
Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Yiu K.H., de G.R.A.A.F. .F.R., van V.E.L.Z.E.N. .J.E., Marsan N.A., Roos C.J., Tse H.F., van D.E. .W.A.L.L. .E.E., Schalij M.J., Bax J.J., Schuijf J.D. and Jukema J.W., Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease. , Neth Heart J. . 2013, 21: 347-53.
Yiu K.H., Invited Speaker at the Shantou University Medical College, Oct 31, 2012 to Nov 2, 2012 “ Cardiovascular Imaging: echocardiography, “Cardiovascular Imaging: computed tomography and cardiac magnetic resonance imaging” , 2012.
Yiu K.H., Invited Speaker, Chinese Medical Association, Taipei, Taiwan June 28-30, 2013 “ New Pharmacologic Therapy of Heart Failure”, 2013.
Yiu K.H., Invited Speaker, Symposa Biopharma Corporation Taiwan, Jan 18-19, 2013 “The Role of Levosimendan for Heart Failure Treatment” , 2013.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.
Yiu K.H., Stoke Prevention in AF July 7-8, 2012, 2012.
Yiu K.H., The 5th Asia Pacific Heart Rhythm Society Scientific Session Oct 3-6, 2012 “ Debate: Con: Optimization of CRT Using Noninvasive Cardiac Output Measurement, 2012.
Yiu Y.F., Yiu K.H., Siu D.C.W., Chan Y.H., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Lau C.P., Cheung B.M.Y. and Tse H.F., Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes, Atherosclerosis. 2013, 227(1): 140-6.
Zhao C., Wang M.M., Siu D.C.W., Hou Y.L., Wang T., Tse H.F. and Yiu K.H., Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress , Cardiovasc Diabetol. . 2012, 5:11(1): 147.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.


Researcher : Yiu WH

Project Title:Functional role of protease activated receptors (PARs) in mediating inflammation and fibrosis in diabetic nephropathy (DN)
Investigator(s):Yiu WH, Tang SCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2012
Completion Date:12/2012


List of Research Outputs

LI R., Yiu W.H., LIN M., WU H., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., Anti-Inflammatory Effects of BMP7 on AGEs-Induced Tubular Injury, J Am Soc Nephrol. 2012, 23: 955A.
Lin M.I.A.O., Yiu W.H., LI R., WU H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy, Kidney International. 2013, 83: 887-900.
Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.


Researcher : Yu CCPV

List of Research Outputs

Frontini M., Kukalev A., Leo E., Ng Y.M., Cervantes M., Cheng C.W., Holic , Dormann , Tse E.W.C., Pommier Y. and Yu C.C.P.V., The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment, Developmental Cell. 2012, 23(2): 356–370.
Grey W., Izatt L., Sahraoui W., NG Y.M., Ogilvie C., Hulse A., Tse E.W.C., Holic R. and Yu C.C.P.V., Deficiency of the Cyclin-Dependent Kinase Inhibitor, CDKN1B, Results in Overgrowth and Neurodevelopmental Delay, Human Mutation. 2013, 34(6): 864-868.


Researcher : Yue W

List of Research Outputs

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Li L.S.W. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration., Circulation Journal. 2012, 76: 682-8.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.


Researcher : Yuen JCH

List of Research Outputs

Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.


Researcher : Yuen MF

Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs



Researcher : Yuen RMF

Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs

CHEUNG F., Feng Y., Wang N., Yuen R.M.F., Tong Y. and Wong V.C.W., Efficacy of Chinese herbal medicine in treating liver fibrosis: a meta-analysis of 14 randomized controlled, 11th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM). 2012.
Cheung F., Feng Y., Wang M.N., Yuen R.M.F., Tong Y. and Wong V.C.W., Efficacy of Chinese herbal medicine in treating liver fibrosis: a meta-analysis of 14 randomized controlled trials, 11th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM). 2012.
Fung J.Y.Y., Yuen R.M.F., Lai C.L. and Ng I.O.L., Do statins reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis B?, Hepatobiliary Surgery and Nutrition. 2013, 2(1): 34-6.
Fung J.Y.Y., Lee C.K., Chan M., Seto W.K.W., Lai C.L. and Yuen R.M.F., High prevalence of non-alcoholic fatty liver disease in the Chinese – results from the Hong Kong liver health census. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands 24–28 April 2013, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S538.
Fung J.Y.Y., Lai C.L., Seto W.K.W., Wong D.K.H. and Yuen R.M.F., Levels of HBV DNA and not HBsAg are associated with biochemical flares after HBeAg seroconversion, Hepatology International. 2012, 6: 52.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Chok K.S.H., Chan A.C.Y., Sharr W.W., Cheung T.T., Dai W.C., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B – long term outcome. (Oral presentation at the Transplant Plenary II Session of the 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 11, 2012), Hepatology. 2012, 56(S1): 196A.
Fung J.Y.Y., Chan S.C., Cheung C.K.Y., Yuen R.M.F., Chok K.S.H., Sharr W.W., Chan A.C., Cheung T.T., Seto W.K.W., Fan S.T., Lai C.L. and Lo C.M., Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B, American Journal of Gastroenterology. 2013, 108(6): 942-8.
Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.
Fung J.Y.Y., Yuen R.M.F. and Lai C.L., The role of steatosis in HBsAg seroclearance for patients with chronic hepatitis B infection: fact or fiction?, Digestive Diseases and Sciences. 2013, 58(1): 20-2.
Fung J.Y.Y. and Yuen R.M.F., This is hepatitis - it is closer than you think., Indian J Med Res. 2012, 136(1): 3-6.
Hon Y.Y.L., Fielding R., Lam W.W.T., Lai C.L., Yuen R.M.F., Ip D.K.M. and Tsang J.W.H., Validation of the Chinese version of the Revised-IPQ: Illness Perception Questionnaire-Revised for Cancer Predisposition (IPQ-CP) (abstract and poster presentation), The third Meeting of East Asian Psycho-Oncology Network (EAPON), 6-7 September 2012, Beijing. Beijing, Peking, 2012, 44-45.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.
Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.
Kim B.K., Fung J.Y.Y., Yuen R.M.F. and Kim S.U., Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives, World Journal of Gastroenterology. 2013, 19(12): 1890–1900.
Lai C.L. and Yuen R.M.F., Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy., Hepatology. 2012, 57(1): 399-408.
Lai C.L. and Yuen R.M.F., Reduction of cirrhosis and hepatocellular carcinoma with antiviral therapy in chronic hepatitis B, Hepatology. 2013.
Lam T.P., Lam C.L.K., Lai C.L., Yuen R.M.F., Fong D.Y.T., McGhee S. and So M.K., Cost-effectiveness Analysis of Anti-viral Treatment in Patients with Chronic Hepatitis B Infection in Hong Kong, Poster presented at the presented at the 2012 International Society for Quality of Life Research Annual Conference in Budapest on Oct 24-27, 2012.
Seto W.K.W., Tanaka Y., Wong D.K.H., Lai C.L., Shinkai N., Yuen J.C.H., Tong T., Fung J.Y.Y., Hung I.F.N. and Yuen R.M.F., Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay, Hepatology International. Springer-Verlag, 2012, 7(1): 98-105.
Seto W.K.W., Fung J.Y.Y., Yuen R.M.F. and Lai C.L., Future prevention and treatment of chronic hepatitis B infection. , J Clin Gastroenterol. 2012, 46(9): 725-34.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28 polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B, Clin Infect Dis. 2013.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Proitsi P., Sham P.C., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, Clinical Infectious Disease. 2013, 56(12): 1695-703.
Seto W.K.W., Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and IL28B polymorphisms and their association with hepatitis B surface antigen seroclearance in chronic hepatitis B, Hepatology. 2012, 56(S1): 1056A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Hepatitis B surfact antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 257.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.
Seto W.K.W., Liu K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir., Antivir Ther. 2012, 17: 1255-62.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Hung I.F.N., Lai C.L. and Yuen R.M.F., Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment, J Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology. 2013.
Seto W.K.W., Wong D.K.H., Lai C.L. and Yuen R.M.F., Reply to Liao et al, Clin Infect Dis. 2013.
Seto W.K.W., Liu K., Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serologic and virologic outcomes of tenofovir in Asian chronic hepatitis B patients with prior nucleoside analogue exposure. (Poster presentation at the 63rd) Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012 on November 10, 2012, Hepatology. 2012, 56(S1): 415A.
Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Tong T., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, Hepatology International. Springer-Verlag, 2012, 7(1): 119-126.
Seto W.K.W., Lam Y.F., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Serum hepatitis B surface antigen levels during five years entecavir therapy in Asian chronic hepatitis B patients., The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S314.
Seto W.K.W., Hui A.J., Wong V.W.S., Wong G.L.H., Liu K., Lai C.L., Yuen R.M.F. and Chan H.L.Y., Serum hepatitis B surface antigen levels to guide the cessation of entecavir in hepatitis B e antigen-negative chronic hepatitis B: an interim analysis. The International Liver Congress™ 2013 – 48th Annual meeting of the European Association for the Study of the Liver Amsterdam, The Netherlands, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2013, 58(Suppl 1): S315.
Seto W.K.W., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B monoinfection, Hepatology International. 2013, 7(2): 327-34.
Wong D.K.H., Kopaniszen M., Fung J.Y.Y., Seto W.K.W., Huang F.Y., Lai C.L. and Yuen R.M.F., Effects of hepatitis B virus quasispecies and reverse transcriptase variants on treatment responsiveness to entecavir, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S317.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clinical Gastroenterology and Hepatology. 2013.
Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleoside/nucleotide analogues of different potency, State Key Laboratory for Liver Research Symposium 2012, HKU. 2012.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese, PLoS One. 2013, 8(6): e66920.
Wong D.K.H., Watanabe T., Tanaka Y., Seto W.K.W., Lee C.K., Fung J.Y.Y., Lin C.K., Huang F.Y., Lai C.L. and Yuen R.M.F., Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese. , Asian Pacific Association for the Study of the Liver Liver Week, Singapore. Hepatology International. 2013, 7 (Suppl 1): S192.
Yuen R.M.F., Hepatitis B virus in patients with concomitant illness, 2nd Asia Hepatology Perspectives Forum, Seoul, Korea. 2012.
Yuen R.M.F., Interleukin IL28B in hepatitis C virus treatment, Symposium 2012 State Key Laboratory for Liver Research, The University of Hong Kong. 2012.
Yuen R.M.F., Natural history in patients with normal or minimally elevated ALT, Journal of Gastroenterology and Hepatology. 2012, 27 (Suppl 5): 7.
Yuen R.M.F., Natural history in patients with normal or minimally elevated ALT, Oral presentation, Asian Pacific Digestive Week 2012, Bangkok, Thailand. 2012.
Yuen R.M.F., Research on hepatitis B infection – A revelatory course, Sir David Todd Lecture, Hong Kong College of Physicians. 2012.
Yuen R.M.F., Sir David Todd Lecture Medal, Hong Kong College of Physicians. 2012.
Zheng M.H., Lin X.F., Shi K.Q., You J., Liu W.Y., Lup Y.W., Wong D.K.H., Yuen R.M.F. and Chen Y.P., Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large case-control study, The 48th annual meeting of The European Association for the Study of the Liver, Amsterdam, The Netherlands. Journal of Hepatology. 2013, 58: S555.


Researcher : Yung SSY

Project Title:The role of TGF-beta1 and phosphatidylinositol 3-kinase activation on perlecan synthesis in mesangial cells
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011
Completion Date:04/2013


Project Title:The role of annexin II and IL-6 in peritoneal inflammation and fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:American Society of Nephrology Kidney Week 2012; Decorin Regulates Cell Activation and Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of ERK Phosphorylation
Investigator(s):Yung SSY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2012


Project Title:The Role of Fibronectin in Peritoneal Inflammation and Fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of microRNAs in fibrogenic processes in mesothelial cells
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


List of Research Outputs

Chan D.T.M., Cheung K.F., Yim A.S.Y., Yap Y.H.D. and Yung S.S.Y., Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis, Journal of the American Society of Nephrology. 2012, 23: 567A.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin Suppresses Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of PKC-alpha Phosphorylation, Peritoneal Dialysis International . 2012, 32: S120.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin suppresses fibrotic processes in human peritoneal mesothelial cells through inhibition of PKC-alpha phosphorylation, 14th Congress of the International Society for Peritoneal Dialysis, Kuala Lumpur, Malaysia. 2012.
Cheung W.T., Yung S.S.Y., Chan D.T.M., Leung P.C.K. and Wong A.S.T., Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion, Molecular Therapy. 2013, 21: 78-90.
HO S.K., Yung S.S.Y., Cheung K.F., Tse W.W. and Chan D.T.M., Anti-dsDNA antibodies induce epithelial-to-mesenchymal transition and fibrotic processes in human proximal renal tubular epithelial cells, ASN Kidney Week 2012. 338A.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin inhibits epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells through inhibition of MAPK phosphorylation, ISN World Congress of Nephrology 2013.
Lui S.L., Yung S.S.Y., Yim A.S.Y., Wong K.M., Tong K.L., Wong K.S., Li C.S., Au T.C., Lo W.K., Ho Y.W., Ng F., Tang S.O.C. and Chan D.T.M., A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport, and Inflammation Markers: A Randomized Clinical Trial, American Journal of Kidney Diseases. 2012, In press.
TSUN G.S., Shiu S.W.M., Wong Y., Yung S.S.Y., Chan D.T.M. and Tan K.C.B., Association between serum amyloid A and scavenger receptor class B type 1-mediated cholesterol efflux to serum in type 2 diabetes., American Diabetes Association 73rd Scientific Sessions, Chicago, USA.. 2013.
Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.
Yung S.S.Y., HO S.K., Cheung K.F. and Chan D.T.M., Anti-dsDNA antibodies induce cell activation and fibronectin synthesis in human renal proximal tubular epithelial cells., ISN World Congress of Nephrology 2013.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.
Yung S.S.Y. and Chan D.T.M., Fibronectin in Renal Diseases and Peritoneal Dialysis, In: Beattie, James, Fibronectin: Current Concepts in Structure, Function and Pathology. New York, Nova Science Publishers, 2012, 227-264.
Yung S.S.Y., Chau K.M., Zhang Q., Zhang C. and Chan D.T.M., Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy, PLoS One. 2013, e54501.
Yung S.S.Y. and Chan D.T.M., The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis, Autoimmune Diseases. 2012.
Zhao M., Liu Q., Liang G., Wang L., Luo S., Tang Q., Zhao H., Su Y., Yung S.S.Y., Chan D.T.M. and Lu Q., E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients, J Autoimmun. 2013, 41: 152-160.


Researcher : ZHANG M

List of Research Outputs

XIE B., ZHANG M., Mak H.K.F. and Cheung R.T.F., Blood pressure variability and silent small vessel cerebrovascular lesions in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 534.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Junior Investigator's Award for poster, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 22: 239.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Lack of association between brachial-ankle pulse wave velocity and white matter hyperintensities in healthy hypertensive elderly Chinese, Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom. 2013, 239.


Researcher : ZHANG Y

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.


Researcher : Zhang C

List of Research Outputs

Yung S.S.Y., Chau K.M., Zhang Q., Zhang C. and Chan D.T.M., Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy, PLoS One. 2013, e54501.


Researcher : Zhang J

List of Research Outputs

Liu M., Zhou M., Bao Y., Xu Z., Li H., Zhang H., Zhu W., Zhang J., Xu A. and Jia W., Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure, Clin Sci (Lond). 2012, 124: 115-122.
Ye H., Zhang J., Xu A. and Hoo R.L.C., Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone, PLoS One. 2013, 8: e65543.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Zhang J

List of Research Outputs

Liu M., Zhou M., Bao Y., Xu Z., Li H., Zhang H., Zhu W., Zhang J., Xu A. and Jia W., Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure, Clin Sci (Lond). 2012, 124: 115-122.
Ye H., Zhang J., Xu A. and Hoo R.L.C., Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone, PLoS One. 2013, 8: e65543.
Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel., Am J Physiol Cell Physiol.. 2012, 303(2): C115-25.


Researcher : Zhang Q

List of Research Outputs

Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin Suppresses Fibrotic Processes in Human Peritoneal Mesothelial Cells through Inhibition of PKC-alpha Phosphorylation, Peritoneal Dialysis International . 2012, 32: S120.
Chan D.T.M., Chau K.M., Yim A.S.Y., Zhang Q. and Yung S.S.Y., Decorin suppresses fibrotic processes in human peritoneal mesothelial cells through inhibition of PKC-alpha phosphorylation, 14th Congress of the International Society for Peritoneal Dialysis, Kuala Lumpur, Malaysia. 2012.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin inhibits epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells through inhibition of MAPK phosphorylation, ISN World Congress of Nephrology 2013.
Yung S.S.Y., Chau K.M., Zhang Q., Yim A.S.Y., JIANG N. and Chan D.T.M., Decorin regulates cell activation and fibrotic processes in human peritoneal mesothelial cells through inhibition of ERK phosphorylation, Journal of American Society of Nephrology. 2012, 23: 550A.
Yung S.S.Y., Chau K.M., Zhang Q., Zhang C. and Chan D.T.M., Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy, PLoS One. 2013, e54501.


Researcher : Zhang Y

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.


Researcher : Zhang Y

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.


Researcher : Zhang Y

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.
LI X., Yeung S.C., ZHANG Y., LIANG Y., Lian Q., Tse H.F., Ip M.S.M. and Mak J.C.W., Effects of induced pluripotent stem cell- and bone marrow-derived mesenchymal stem cells on cigarette smoke-induced lung damage in rats, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 33.
LIANG X., ZHANG Y., Ding Y., Tse H.F. and Lian Q., Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives., Cell Transplant. . 2013.
LIANG Y., LI X., ZHANG Y., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., The effect of human mesenchymal stem cell on cigarette smoke-induced alterations of cardiac function and lipid metabolism in rat, Hong Kong Med. J.. 2013, 19 (Suppl. 1): 35.
Wu H., Sun H., Wu W., Zhang Y., Qin G.W. and Li G.R., Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels, PLoS One. 2013, 8(3): e57864.
Xu X.H., Sun H., Zhang Y., Wu W., Chen K.H., Liu Y., Deng C.Y., Yu X.Y., Jin M.W. and Li G.R., Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells, PLoS ONE . 2012, 7(12): e51550.
ZHANG Y., LIANG X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration, Expert Review of Cardiovascular Therapy. 2013, 11: 505-17.
Zhang Y., Liang X., Lian Q. and Tse H.F., Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration. r, Expert Rev Cardiovasc The. 2013, 11: 505-17.
Zhang Y., Sun H., Chen K.H., Du X.L., Liu B., Cheng L.C., Li X., Jin M.W. and Li G.R., Evidence for functional expression of TRPM7 channels in human atrial myocytes, Basic Res Cardiol. 2012, 107(5): 282.
Zhang Y., Sun H. and Li G.R., Functional Ion Channels in Human Cardiac C-Kit+ Progenitor Cells, 17th Research Postgraduate Symposium. December 12&13, 2012. HKU Medicine. 2012, 178.
Zhang Y., Liao S., Yang M., Liang X., Poon M.W., Tse H.F. and Lian Q., Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension, Cell Transplant.. 2012, 21(10): 2223-39.
Zhang Y., Sun H. and Li G.R., Roles of Functional Ion Channels in Human Cardiac c-Kit+ Progenitor Cells , American Heart Association Scientific Sessions 2012, 3-7 November 2012, Los Angeles, USA. Circulation. 2012, 126: A17155.


Researcher : Zhao C

List of Research Outputs

Yiu K.H., Zhao C., Chen Y., Siu D.C.W., Chan Y.H., Lau G.K.K., Liu S., Lau C.P. and Tse H.F., Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus, Cardiovascular Diabetology. 2013, 12: 94.
Yiu K.H., Yeung C.K., Zhao C., Chan C.Y.J., Siu D.C.W., Tam S., Wong C.S., Yan G., Yue W. and Khong P.L., Prevalence and extent of subclinical atherosclerosis in patients with psoriasis, Journal of Internal Medicine. 2013, 273(3): 273-282.
Zhao C., Wang M.M., Siu D.C.W., Hou Y.L., Wang T., Tse H.F. and Yiu K.H., Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress , Cardiovasc Diabetol. . 2012, 5:11(1): 147.
Zhao C., Yeung C.K., Siu D.C.W., Tam S., Chan J., Chan H.H., Tse H.F. and Yiu K.H., Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. , J Eur Acad Dermatol Venereol. 2013.


Researcher : Zheng C

List of Research Outputs

Li Y., Lam S.K., Mak J.C.W., Zheng C. and Ho J.C.M., Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer, Lung cancer. 2013.
Zheng C., Lam S.K. and Ho J.C.M., Reactive Oxidative Species Take a Pivotal Role in Arsenic Trioxide induced Cell Death in Small Cell Lung Cancer Cells Via Regulation of Notch1 and HIF-1 a, Asian Pacific Society of Respirology. 2012.


Researcher : Zhou L

List of Research Outputs

Ho W.L., Liu H., Lu S., Tse H.M., Chan K.H., Kung M.H.W., Zhou L. and Ramsden D.B., Synaptic dysfunction implicated in parkinsonian leucine-rich repeat kinase-2 (LRRK2) R1441G knockin mice, 8th International Symposium on Health Aging, Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 9-10 March, 2013.


Researcher : Zhou M

List of Research Outputs

Hoo R.L.C., LEE P.C., Zhou M., Xu A. and Lam K.S.L., Best Oral Presentation Award, 7th International HuaXia Congress of Endocrinology. 2012.
Hoo R.L.C., LEE P.C., SHU L., Zhou M., Lam K.S.L. and Xu A., Best Oral Presnetation Award, Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong . 2013.
Hoo R.L.C., LEE P.C., Zhou M., Wong Y.L., Xu A. and Lam K.S.L., Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice., 7th Huaxia Congress of Endocrinology. 2012.


Researcher : Zhou P

List of Research Outputs

Xiao Y., Xu A., Hui X., Zhou P., Li X., Zhong H., Tang W., Huang G. and Zhou Z., Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes., Immunometabolism: from mechanisms to therapeutic applications. PLOS, 2013, 8: e66607.


Researcher : Zou B

List of Research Outputs

TSE M.K., CHO C.K.L., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAORING-binding domain of XAF1, 6th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.
Tse M.K., Cho L.C.K., WONG W.F., Zou B., HUI S.K., Wong B.C.Y. and Sze K.H., Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1., Protein Sci.. Wiley, 2012, 21: 1418-1428.


Researcher : Zuo M

List of Research Outputs

Chong B.H., Pong V., Lam K.F., Liu S., Zuo M., Lau Y.F., Lau C.P., Tse H.F. and Siu D.C.W., Frequent Premature Atrial Complexes Predict New Occurrence of Atrial Fibrillation and Adverse Cardiovascular Events, In: A. John Camm, Europace. London, Oxford University Press, 2012, 14: 942-947.


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