Dept of Physiology

DEPT OF PHYSIOLOGY

Researcher : Ballard HJ

Project Title:	Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in exercise-induced ATP release
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	01/2013

Project Title:	Involvement of chloride channels in ATP release from skeletal muscle
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Involvement of connexin hemichannels in ATP release from skeletal muscle
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

LU L., Tu J. and Ballard H.J., cAMP/PKA-activated CFTR is required for acidosis-induced release of ATP from skeletal myocytes, Journal of the Hong Kong College of Cardiology. Hong Kong, Hong Kong College of Cardiology, 2012, 20 (4): 50.

TU J., LU L., CAI W. and Ballard H.J., cAMP/Protein Kinase A activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP release from rat skeletal muscle during low pH or contractions in vivo., PLoS One. San Francisco, California, Public Library of Science, 2012, 7 (11): e50157.

Researcher : Botelho FP

List of Research Outputs

Botelho F.P., Hu H., Lai C.H. and Chan Y.S., (Sun Chieh Yeh Foundation Young Investigator Award). Brain-derived neurotrophic factor-mediated inhibitory neurotransmission regulates developmental acquisition of graviceptive behavior in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse 52. 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF regulates plasticity in spatial coding. International Society of Neurochemistry Symposium on Nervous Systems and Diseases : Models and Mechanisms , 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation, Soc. Neuroscience Abstract (USA), 735.11/A55. 2012.

Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus, 11^th Biennial Meeting of Asia-Pacific Society of Neurochemistry Journal of Neurochemistry 123 (Suppl. 1): 80. 2012.

Researcher : Bourreau JP

Project Title:	Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock?
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Endothelim-dependent hyperpolarization and relaxation of vascular smooth muscle: influence of the mode of excitation-coupling of vasoconstrictors
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Switch in G-protein coupling. Role of intracellular cAMP
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2006

Researcher : Bu L

Project Title:	Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):	Bu L, Li RA
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Human WT1 epicardial progenitor cells
Investigator(s):	Bu L, Li RA
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Study of cardiomyopathy through genome editing in human pluripotent stem cells
Investigator(s):	Bu L, Li RA
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Researcher : CAI W

List of Research Outputs

TU J., LU L., CAI W. and Ballard H.J., cAMP/Protein Kinase A activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP release from rat skeletal muscle during low pH or contractions in vivo., PLoS One. San Francisco, California, Public Library of Science, 2012, 7 (11): e50157.

Researcher : Cai S

Project Title:	Stem Cells and Developmental Mechanisms; CHARACTERIZATION OF HUMAN BONE MARROW STROMAL CELLS FOLLOWING DIFFERENTIATION INTO SCHWANN CELLS
Investigator(s):	Cai S
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2012

List of Research Outputs

Cai S., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of human neural crest stem cells from human induced pluripotent stem cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Researcher : Chan YS

Project Title:	30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	The role of central glial cells in the pathogenesis of Parkinson's Disease
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2006

Project Title:	Role of the thalamus in integrating spatial information and guiding navigation
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Determinants of developmental plasticity in the vestibular system
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2009

Project Title:	Outstanding Research Student Supervisor Award 2009-10
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2010

Project Title:	Brain-derived neurotrophic factor regulates plasticity in the vestibular system
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	42nd Annual Meeting of Society for Neuroscience; Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

List of Research Outputs

Botelho F.P., Hu H., Lai C.H. and Chan Y.S., (Sun Chieh Yeh Foundation Young Investigator Award). Brain-derived neurotrophic factor-mediated inhibitory neurotransmission regulates developmental acquisition of graviceptive behavior in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse 52. 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF regulates plasticity in spatial coding. International Society of Neurochemistry Symposium on Nervous Systems and Diseases : Models and Mechanisms , 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation, Soc. Neuroscience Abstract (USA), 735.11/A55. 2012.

Cai S., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of human neural crest stem cells from human induced pluripotent stem cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Chan Y.S., Developmental plasticity of neural circuitry for spatial coding. Journal of Physiological Sciences, 90^th Anniversary Conference of the Physiological Society of Japan. PJS-CAPS Symposium. Journal of Physiological Sciences. 2013, 63: S36.

Chan Y.S., Developmental plasticity: The engagement of glutamate receptors in mediating spatial coding. Int’l Conference of Physiological Sciences 2012 , The Physiological Society (UK) Symposium Identifying Physiological and Pathophysiological Roles for Ionotropic Glutamate Receptor Subtypes. Acta Physiologica Sinica . 2012, 64: 4.

Chan Y.S., Integrative learning in medical education, [PBL and W-PBL Forum. Guangzhou, China]. 2013.

Chan Y.S., Medical education for neomillenial learning, Medical Education Forum. Fuzhou China. 2012.

Chan Y.S., Lai S.K., Jiang B. and Lai C.H., Postnatal tuning of the vestibulo-olivo- cerebellar circuitry for spatial coding, Abstracts of 5^th Int’l Symposium of the Society for Research on Cerebellum, p. 35. . 2012.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., (Excellent Poster Presentation Award). Topographic organization of thalamic neurons responsive to rotational and translational head movements. Int'l Conference of Physiological Sciences 2012. , Acta Physiologica Sinica . 2012, 64: 245.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., Topographic representation of thalamic neurons in head movement inputs, Abstracts of 8th Int’l Symp. on Healthy Aging: 62. 2013.

Chu J.M.T., Chan Y.S., Chen L.W. and Yung K.K., Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway, J. Neurochemistry. 2012, 123: 417-427.

Gao J., Cheung R.T.F., Chan Y.S., Chu L.W. and Lee T.M.C., Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed, Neuropsychology, Development and Cognition, Serial B. 2013.

Gao J., Cheung R.T.F., Chan Y.S., Chu L.W., Mak H.K.F. and Lee T.M.C., Relevance of short-range connectivity to brain compensation and cognitive efficiency in healthy and pathological ageing: a combined functional magnetic resonance imaging and tractography study on prospective memory, Eighteenth Medical Research Conference, Department of Medicine, The University of Hong Kong, 12th January 2013, Lecture Theatre IV, Faculty of Medicine Building. Hong Kong Medical Journal. 2013, 19 (Suppl 1): 19.

Han L., Lai S.K., Lai C.H. and Chan Y.S., (Best Young Investigator Award). 5-HT-induced robust enhancement of neurotransmission in rat medial vestibular nucleus, Int’l Conference of Physiological Sciences 2012. Acta Physiologica Sinica . 2013, 64:71.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic enhancement of synaptic transmission in rat medial vestibular nucleus, Soc. Neuroscience Abstract (USA), 430.14/B50. 2012.

Han L., Lai S.K. and Chan Y.S., Serotoninergic effect on electrical induced synaptic transmission in medial vestibular nucleus, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 69. 2013.

Ke Y., Chan Y.S. and Yung W.H., Mechanism of chronic intermittent hypoxia-induced impairment in synaptic plasticity and neurocognitive dysfunction, Science Supplement. Advances in High-Altitude Medicine and Hypoxic Physiology. 2012, 20-21.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized chondroitinase ABC I and II on chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 68. 2013.

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized Chondroitinase ABC I and II on Chitosan Beads Improve Axonal Regrowth in CSPG-Enriched Astrocyte Culture, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P41. 2013.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., A role of proheparanase in synaptic plasticity, Abstracts of 8th Int’l Symp. on Healthy Aging: 66. 2013.

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Lui N.P., Chen L.W., Yung W.H., Chan Y.S. and Yung K.K., Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat parkinsonism., PLoS One. 2012, 7: e51294.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic function in the central vestibular circuitry. Int’l Conference of Physiological Sciences 2012, The Chinese Association for Physiological Sciences Symposium - Synaptic Function and Plasticity in Health and Disease. Acta Physiologica Sinica . 2012, 64: 11.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior system, Abstracts of 8th Int’l Symp. on Healthy Aging: 70. 2013.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 70. 2013.

Ng O.T., Chen L.W., Chan Y.S. and Yung K.K.L., Small Interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase., Neurosignals. 2013, 21: 42-54.

Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus, 11^th Biennial Meeting of Asia-Pacific Society of Neurochemistry Journal of Neurochemistry 123 (Suppl. 1): 80. 2012.

Shi W., Hu H., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of central vestibular synapses and vestibular behaviors in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 60. 2013.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

Szeto Y.Y., Au Y.K., Chu K.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Lovell-Badge R.H., Chan W.Y., Sham M.H. and Cheah K.S.E., Dysregulation of Aqp3 and Endolymphatic Hydrops in a Mouse Model of Campomelic Dysplasia, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, Hong Kong, November 26-27. 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned Chitosan Nanofibers for Culturing Schwann Cells to Guide Axonal Growth, 8th Int’l Symp. on Healthy Aging: How to age with finesse:P20. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The Effects of Chondroitinase ABC Digestion Products on Neurite Growth: Saccharide Length and Sulphation Pattern, 8th Int’l Symp. on Healthy Aging: How to age with finesse: P3. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The effects of chondroitinase ABC digestion products on neurite growth: Saccharide length and sulphation pattern, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 58. 2013.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: therapeutic potential and developmental origin, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy with oligodendrocyte precursor derivation from bone marrow stromal cells, Soc. Neuroscience Abstract (USA), 632.06/A6. 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursor cells from bone marrow stromal cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers for culturing oriented Schwann cells to guide axonal growth, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Chitosan fibers for culturing aligned Schwann cells for nerve regeneration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

WANG B., Liu Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15, 2013.. 2013.

WANG B., LIU Y., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in mammalian inner ear development, 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, CUHK, Hong Kong, June 15. 2013.

Wong M.K., Lui Y.Y., Chan Y.S. and Shum D.K.Y., Chondroitin sulfate moieties control motor neuron migration in the rat embryonic hindbrain, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 67. 2013.

Researcher : Chen J

Project Title:	Molecular Mechanism of Gating Defects in DeltaF508-CFTR Cl– Channel
Investigator(s):	Chen J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2011

Project Title:	Effects of Influenza A (H1N1) Virus Infection on Ion Transport of Pig Tracheal Epithelia
Investigator(s):	Chen J, Chen H, Li GR
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Cai Z., Li H., Chen J. and Sheppard D.N., Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms, Am.J.Physiol Cell Physiol. 2013.

Reznikov L.R., Dong Q., Chen J., Moninger T.O., Park J.M., Zhang Y., Du J., Hildebrand M.S., Smith R.J., Randak C.O., Stoltz D.A. and Welsh M.J., CFTR-deficient pigs display peripheral nervous system defects at birth, Proc.Natl.Acad.Sci.U.S.A. 2013, 110(8).

Stoltz D.A., Rokhlina T., Ernst S.E., Pezzulo A.A., Ostedgaard L.S., Karp P.H., Samuel M.S., Reznikov L.R., Rector M.V., Gansemer N.D., Bouzek D.C., Alaiwa M.H., Hoegger M.J., Ludwig P.S., Taft P.J., Wallen T.J., Wohlford-Lenane C., McMenimen J.D., Chen J., Bogan K.L., Adam R.J., Hornick E.E., Nelson G.A., Hoffman E.A., Chang E.H., Zabner J., McCray P.B., Prather R.S., Meyerholz D.K. and Welsh M.J., Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs, J.Clin.Invest. 2013, 123(6).

Researcher : Chen K

List of Research Outputs

Li G.R., Chen K. and Sun H., Distinctive density,biophysical properties, and pharmacology of voltage-gated sodium current in atrial and ventricular myocytes. Heart Rhythm 34th Annual Scientific Sessions. May 8-11, 2013. Denver, Colorado, USA, Heart Rhythm . 2013, 10(5S): S322.

Researcher : Chen W

List of Research Outputs

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., (Excellent Poster Presentation Award). Topographic organization of thalamic neurons responsive to rotational and translational head movements. Int'l Conference of Physiological Sciences 2012. , Acta Physiologica Sinica . 2012, 64: 245.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., Topographic representation of thalamic neurons in head movement inputs, Abstracts of 8th Int’l Symp. on Healthy Aging: 62. 2013.

Researcher : Cheung KH

Project Title:	Presenilin Regulates Capactitative Calcium Entry – Implications for Alzheimer’s Disease Pathogenesis
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011
Completion Date:	01/2013

Project Title:	Molecular Mechanism of Capacitative Calcium Entry Deficits in Presenilin Mutations and Its Role in Alzheimers Disease Pathogenesis
Investigator(s):	Cheung KH, Chan YS, Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	PS-TPC2 interaction: Mechanisms for autophay pathology in AD
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Nuclear membrane electrophysiology of Ryanodine Receptor Channel
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Ma Z., Siebert A.P., Cheung K.H., Lee R.J., Johnson B., Cohen A.S., Vingtdeux V., Narambaud P. and Foskett J.K., Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability., Proc Natl Acad Sci U S A. 2012, 109: E1963-71.

Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism Disrupted Capacitative Calcium Entry Familial Alzheimer’s Disease, Gordon Conference - Calcium Signalling 2013.

Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism of Capacitative Calcium Entry Deficits in PS1-Linked Familial Alzheimer’s Disease, 2013.

YE Y., Xu Y., Liang W., Leung G.P.H., Cheung K.H., Zheng C., Chen F. and Lam J.K.W., DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells, Journal of Drug Targeting. 2013, 21: 474-486.

Researcher : Chung SSM

List of Research Outputs

Chung S.K., Chung S.S.M. and Chihiro H., Protective agent for retinal nerve or optic nerve, 2013, Patent No. 13155114.5 - 1464.

Researcher : Fung ML

Project Title:	Pathophysiological roles of pro-inflammatory cytokines in the carotid body in intermittent hypoxia
Investigator(s):	Fung ML, Tipoe GL
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Oxidative stress mediates endothelial dysfunction, vascular inflammation and systemic hypertension in rats with chronic intermittent hypoxia
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	Pathophysiological mechanisms of myocardial dysfunction in intermittent hypoxia: roles of oxidative stress in impaired calcium homeostasis
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Neuroprotective effect of Lycium barbarum polysaccharides against hippocampal apoptosis induced by chronic intermittent hypoxia in rats
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Fung M.L., NO-mediated hippocampal potassium channel dysfunction in sleep apnea. The 1^st International Chinese Symposium on Free Radical Research, Lanzhou China 8/2012 , (Acta Biophysica Sinica 28: 27. Suppl, 2012). 2012.

Fung M.L., Tipoe G.L. and Leung P.S., Paracrine-autocrine mechanisms in the carotid body function at high altitude and in disease. Advances in High-Altitude Medicine and Hypoxic Physiology in China, Edited by Sean Sanders, Fan Ming. Science (Suppl), 66-68, 2012. (Open Access URL /http://science.imirus.com/Mpowered/book/vscim12/i8/p1). 2012.

Fung M.L., Tipoe G.L. and Leung P.S., Paracrine-autocrine mechanisms in the carotid body function at high altitude and in disease, In: Sean Sanders, Fan Ming, Advances in High-Altitude Medicine and Hypoxic Physiology in China. 2012, Science (Suppl): 66-68.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Lam S.S.Y., LIU Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia , Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Colin Nurse, Constancio Gonzalez, Chris Peers, Nanduri R. Prabhakar Springer, New York (ISBN 978-94-007-4583-4) . 2012, 758: 301-306.

Lam S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, In: C.A. Nurse et al, Arterial chemoreception: From Molecules to Systems, Advances in Experimental Medicine and Biology. Springer Science+Business Media Dordrecht, 2012, 758: chapter 41 301-306.

Lau T.H.Y., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji A.A., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Lau T.Y.H., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji J., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Liu Y., Tian X.Y., Mao G., Fang X., Fung M.L., Shyy Y.J., Huang Y. and Wang N., Peroxisome proliferator –activated receptor gamma ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor, Hypertension. 2012, 60: 1471-1478.

Liu Y., Tian X.Y., Mao G., Fang X., Fung M.L., J Shyy J.Y., Huang Y. and Wang N., Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation, Hypertension 61(4):e30, 2013.. 2013.

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

PAN J., Xiao J., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces oxidative stress and apoptosis via angiotensin II receptor 1in the rat liver, 17^th Research Postgraduate Symposium, HKU, P2.29, 12/2012.

PAN J., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Telmisartan ameliorates oxidative stress and apoptosis in the liver of rats exposed to chronic intermittent hypoxia, The 16^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP7, 11/2012. Journal of the Hong Kong College of Cardiology, . 2012, 20(2):55.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise ameliorates left ventricular hypertrophy induced by high fat diet in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P29, 3/2013.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., Guo R., Fung M.L., Liong E.C. and Tipoe G.L., Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future chanllenges, Hepatobiliary Pancreatic Diseases International. 2013, 12: 125-135.

Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Tipoe. Garlic-derived S-allylmercaptocysteine is a novel hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2013, 52: 179-191.

Researcher : Graeff RM

List of Research Outputs

Graeff R.M. and Lee H.C., An Improved Enzymatic Cycling Assay for NAADP, In: A. Galione A. Guse, Messenger. USA, American Scientific, 2013, 2: 96-105.

Jiang H., Sherwood R., Zhang S., Zhu X., Liu Q., Graeff R.M., Kriksunov I.A., Lee H.C., Hao Q. and Lin H.N., Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry, Analytical Biochemistry. 2013, 433: 218-226.

Liu Z., Graeff R.M., Jin H., Zhang L. and Zhang L., Studies on CD38 Inhibitors and Their Application to cADPR-Mediated Ca2+ Signaling, In: H C Lee, Messenger. USA, American Scientific, 2013, 2: 19-32.

Moreau C., Liu Q., Graeff R.M., Wagner G.K., Thomas M.P., Swarbrick J.M., Shuto S., Lee H.C., Hao Q. and Potter B.V.L., CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template, PLoS ONE. 2013, 8: e66247.

Zhang H., Graeff R.M., Lee H.C. and Hao Q., Crystal Structures of Human CD38 in Complex with NAADP and ADPRP, Messenger . 2013, 2: 44-53.

Researcher : Han L

Project Title:	42nd annual meeting of society for neuroscience, 2012, U.S.A.; Serotonergic enhancement of synaptic transmission in rat medial vestibular nucleus
Investigator(s):	Han L
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	Monoaminergic control of synaptic functions in the vestibular nucleus
Investigator(s):	Han L, Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2013

List of Research Outputs

Chan Y.S., Li C., Han L., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations, Society Neuroscience Abstract (USA), 470.12/DD17. 2012.

Han L., Lai S.K., Lai C.H. and Chan Y.S., (Best Young Investigator Award). 5-HT-induced robust enhancement of neurotransmission in rat medial vestibular nucleus, Int’l Conference of Physiological Sciences 2012. Acta Physiologica Sinica . 2013, 64:71.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic enhancement of synaptic transmission in rat medial vestibular nucleus, Soc. Neuroscience Abstract (USA), 430.14/B50. 2012.

Han L., Lai S.K. and Chan Y.S., Serotoninergic effect on electrical induced synaptic transmission in medial vestibular nucleus, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 69. 2013.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Ma C.W., Lam Y.L., Cham W.C., Han L., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic function of the central vestibular system, Gordon Research Conferences (Proteoglycans), Andover, USA. Jul 8-13. 2012.

Researcher : Hao B

List of Research Outputs

Yu P., Zhang Z., Hao B., Zhao Y., Zhang L., Lee H.C., Zhang L. and Yue J., A novel fluorescent cell membrane permeable caged cyclic ADP-Ribose analogue, J Biol Chem. 2012, 287: 24774-24783.

Researcher : Hao Q

Project Title:	A new method for macromolecular structure determination: envelope-based phasing
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009
Completion Date:	09/2012

Project Title:	Structural biology of sirtuins
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Engineering CD38 for Calcium Signaling
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Structure and Function of the TRPM2 channel
Investigator(s):	Hao Q, Kotaka M, Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Structural Basis of an Inflammatory Disease caused by IL-10R1 mutations
Investigator(s):	Hao Q, Lau YL
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

Project Title:	Structural Biology of Human PECAM-1 (CD31) in Cell Adhesion and Leukocyte Transmigration
Investigator(s):	Hao Q, Zhang H
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

List of Research Outputs

Hao Q., Data Collection Strategy and Initial Data Quality Analysis using Synchrotron Radiation, Workshop on Protein Crystal Structure Determination, Shanghai, China. 2012.

Hao Q., OASIS and IPCAS, International Workshop on New Developments of Methods and Software for Protein Crystallography, Xian, China. 2012.

Hao Q., Structural Basis for Novel Posttranslational Modifications regulated by Sirtuins, International Conference on Nucleic Acid Enzymes and Enzymes in Human Diseases, Hong Kong. 2013.

Hao Q., Structural Basis for Novel Posttranslational Modifications regulated by Sirtuins, Taiwan Proteomics Society International Conference: Recent Advances in Translational Medicine. 2013.

Jiang H., Sherwood R., Zhang S., Zhu X., Liu Q., Graeff R.M., Kriksunov I.A., Lee H.C., Hao Q. and Lin H.N., Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry, Analytical Biochemistry. 2013, 433: 218-226.

Jiang H., Khan S., Wang Y., Charron G., Sebastian C., Du J.T., Kim R., Ge E., Mostoslavsky R., Hang H.C., Hao Q. and Lin H.N., SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine, Nature. 2013, 496: 110-113.

Moreau C., Liu Q., Graeff R.M., Wagner G.K., Thomas M.P., Swarbrick J.M., Shuto S., Lee H.C., Hao Q. and Potter B.V.L., CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template, PLoS ONE. 2013, 8: e66247.

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of differic and ferro-bismuth bound human serum transferrin, 6th Asian Biological Inorganic Chemistry . 2012.

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of differic and ferro-bismuth bound human serum transferrin, 6^th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of metal bound human serum transferrin reveal a partially-opened conformation in its N-lobe, Metals in Biology, Gordon Research Conferences. 2013.

WANG Y., Dutta S., Karlberg H., Devignot S., Weber F., Hao Q., Tan Y.J., Mirazimi A. and Kotaka M., STRUCTURE OF CRIMEAN-CONGO HAEMORRAGHIC FEVER VIRUS NUCLEOPROTEIN: SUPERHELICAL HOMO-OLIGOMERS AND THE ROLE OF CASPASE-3 CLEAVAGE, Journal of Virology. 2012, 86: 12294-303.

Wang L., WANG M., Zhang H., Hao Q. and Sun H., Structural comparison of metal-bound human serum transferrin, 6th Asian Biological Inorganic Chemistry . 2012.

Wang L., WANG M., Zhang H., Hao Q. and Sun H., Structural comparison of metal-bound human serum transferrin, 6^th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.

Yang N., Zhang H., WANG M., Hao Q. and Sun H., Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe, Scientific Reports. Nature Publishing Group, 2012, 2: 999.

Zhang H., Graeff R.M., Lee H.C. and Hao Q., Crystal Structures of Human CD38 in Complex with NAADP and ADPRP, Messenger . 2013, 2: 44-53.

Zhou W., Yan H. and Hao Q., Analysis of surface structures of hydrogen bonding in protein–ligand interactions using the alpha shape model, Chemical Physics Letters. 2012, 545: 125-131.

Zhou W., Yan H., Fan X. and Hao Q., Prediction of Protein-Protein Interactions Based on Molecular Interface Features and the Support Vector Machine, Current Bioinformatics. 2013, 8: 3-8.

Zhou Y.Y., Zhang H., He B., Du J.T., Lin H.N., Cerione R.A. and Hao Q., The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5), Journal of Biological Chemistry. 2012, 287: 28307-28314.

Researcher : He RJ

List of Research Outputs

Tso H.W., He R.J. and Chan C.W.Y., Engineering of the immune system for human ESC- and iPSC-derived grafts, Drug Discovery Today: Disease Models. 2012, 9: e171-178.

Researcher : Hu H

List of Research Outputs

Botelho F.P., Hu H., Lai C.H. and Chan Y.S., (Sun Chieh Yeh Foundation Young Investigator Award). Brain-derived neurotrophic factor-mediated inhibitory neurotransmission regulates developmental acquisition of graviceptive behavior in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse 52. 2013.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Shi W., Hu H., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of central vestibular synapses and vestibular behaviors in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 60. 2013.

Researcher : Kotaka M

Project Title:	Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on influenza A viral RNA recognition and discrimination by RIG-I
Investigator(s):	Kotaka M, Hui PY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Structural determination of potential anti-malarial drug targets
Investigator(s):	Kotaka M
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	05/2013

Project Title:	Structural determination of Crimean-Congo Haemorrhagic Fever viral nucleocapsid protein
Investigator(s):	Kotaka M
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

List of Research Outputs

Chen M.W., Kotaka M., Vonrhein C., Bricogne G., Rao F., Chuah M.L., Svergun D., Schneider G., Liang Z.X. and Lescar J., Structural Insights into the Regulatory Mechanism of the Response Regulator RocR from Pseudomonas aeruginosa in Cyclic Di-GMP Signaling, Journal of Bacteriology. 2012, 194: 4837-46.

Lam K.H., Lam W.W.L., Wong J.Y.K., Chan L.C., Kotaka M., Ling T.K.W., Jin D., Ottermann K.M. and Au S.W.N., Structural basis of FliG-FliM interaction in Helicobacter pylori., Molecular Microbiology. 2013, 88: 798-812.

Tanner J.A., Cheung Y.W. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis, PCT International Application. 2013, PCT/CN2013/071467.

WANG Y., Dutta S., Karlberg H., Devignot S., Weber F., Hao Q., Tan Y.J., Mirazimi A. and Kotaka M., STRUCTURE OF CRIMEAN-CONGO HAEMORRAGHIC FEVER VIRUS NUCLEOPROTEIN: SUPERHELICAL HOMO-OLIGOMERS AND THE ROLE OF CASPASE-3 CLEAVAGE, Journal of Virology. 2012, 86: 12294-303.

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2012.

Researcher : LAM CS

List of Research Outputs

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Researcher : LIU Y

List of Research Outputs

Lam S.S.Y., LIU Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia , Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Colin Nurse, Constancio Gonzalez, Chris Peers, Nanduri R. Prabhakar Springer, New York (ISBN 978-94-007-4583-4) . 2012, 758: 301-306.

Researcher : LU L

List of Research Outputs

LU L., Tu J. and Ballard H.J., cAMP/PKA-activated CFTR is required for acidosis-induced release of ATP from skeletal myocytes, Journal of the Hong Kong College of Cardiology. Hong Kong, Hong Kong College of Cardiology, 2012, 20 (4): 50.

TU J., LU L., CAI W. and Ballard H.J., cAMP/Protein Kinase A activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP release from rat skeletal muscle during low pH or contractions in vivo., PLoS One. San Francisco, California, Public Library of Science, 2012, 7 (11): e50157.

Researcher : LU Y

List of Research Outputs

ZHANG Z.F., LU Y. and Yue J., Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells, Plos One. 2013, 8(6): e66077.

Researcher : Lai CH

List of Research Outputs

Botelho F.P., Hu H., Lai C.H. and Chan Y.S., (Sun Chieh Yeh Foundation Young Investigator Award). Brain-derived neurotrophic factor-mediated inhibitory neurotransmission regulates developmental acquisition of graviceptive behavior in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse 52. 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF regulates plasticity in spatial coding. International Society of Neurochemistry Symposium on Nervous Systems and Diseases : Models and Mechanisms , 2013.

Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., BDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation, Soc. Neuroscience Abstract (USA), 735.11/A55. 2012.

Chan Y.S., Li C., Han L., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental changes in ionotropic glutamate receptor subunits in rat inferior olivary neurons responsive to linear accelerations, Society Neuroscience Abstract (USA), 470.12/DD17. 2012.

Chan Y.S., Lai S.K., Jiang B. and Lai C.H., Postnatal tuning of the vestibulo-olivo- cerebellar circuitry for spatial coding, Abstracts of 5^th Int’l Symposium of the Society for Research on Cerebellum, p. 35. . 2012.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., (Excellent Poster Presentation Award). Topographic organization of thalamic neurons responsive to rotational and translational head movements. Int'l Conference of Physiological Sciences 2012. , Acta Physiologica Sinica . 2012, 64: 245.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., Topographic representation of thalamic neurons in head movement inputs, Abstracts of 8th Int’l Symp. on Healthy Aging: 62. 2013.

Han L., Lai S.K., Lai C.H. and Chan Y.S., (Best Young Investigator Award). 5-HT-induced robust enhancement of neurotransmission in rat medial vestibular nucleus, Int’l Conference of Physiological Sciences 2012. Acta Physiologica Sinica . 2013, 64:71.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic enhancement of synaptic transmission in rat medial vestibular nucleus, Soc. Neuroscience Abstract (USA), 430.14/B50. 2012.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Ma C.W., Zhang F.X., Lai C.H., Lai S.K., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations, Journal of Comparative Neurology. 2013, 521: 612-625.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior system, Abstracts of 8th Int’l Symp. on Healthy Aging: 70. 2013.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 70. 2013.

Ma C.W., Lai C.H., Chow B.K.C., Shum D.K.Y. and Chan Y.S., Topography of inferior olivary neurons that encode canal and otolith inputs, Cerebellum. 2013, 12: 322-324.

Researcher : Lai SK

List of Research Outputs

Chan Y.S., Lai S.K., Jiang B. and Lai C.H., Postnatal tuning of the vestibulo-olivo- cerebellar circuitry for spatial coding, Abstracts of 5^th Int’l Symposium of the Society for Research on Cerebellum, p. 35. . 2012.

Han L., Lai S.K., Lai C.H. and Chan Y.S., (Best Young Investigator Award). 5-HT-induced robust enhancement of neurotransmission in rat medial vestibular nucleus, Int’l Conference of Physiological Sciences 2012. Acta Physiologica Sinica . 2013, 64:71.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic enhancement of synaptic transmission in rat medial vestibular nucleus, Soc. Neuroscience Abstract (USA), 430.14/B50. 2012.

Han L., Lai S.K. and Chan Y.S., Serotoninergic effect on electrical induced synaptic transmission in medial vestibular nucleus, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 69. 2013.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Ma C.W., Zhang F.X., Lai C.H., Lai S.K., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations, Journal of Comparative Neurology. 2013, 521: 612-625.

Researcher : Lam MC

List of Research Outputs

Zhao Y., Lam M.C. and Lee H.C., Co-expression of two opposite orientations of CD38, Science Signaling. 2012.

Zhao Y., Lam M.C. and Lee H.C., The membrane-bound enzyme CD38 exists in two opposing orientations., In: Michael B. Yaffe, Sci Signal. . Washington DC, American Association for the Advancement of Science, 2012, 5 (241): ra67.

Researcher : Lam SSY

Project Title:	An investigation into the synergistic effect of prenatal infection and hypoxia on brain and behavioural abnormalities relevant to Schizophrenia and related neurodevelopmental disorders
Investigator(s):	Lam SSY, McAlonan GM, Chua SE
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

Project Title:	Protein Expression of Rat Prefrontal Cortex following Perinatal Asphyxia: Implications of Schizophrenia and Related Disorders
Investigator(s):	Lam SSY, McAlonan GM, Chua SE
Department:	Psychiatry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2012

List of Research Outputs

Lam S.S.Y., LIU Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia , Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Colin Nurse, Constancio Gonzalez, Chris Peers, Nanduri R. Prabhakar Springer, New York (ISBN 978-94-007-4583-4) . 2012, 758: 301-306.

Researcher : Lee HC

Project Title:	Structure and Function of the ADP-ribosyl Cyclases.
Investigator(s):	Lee HC, Hao Q, Li GR
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	Regulation of the Calcium Messenger Cyclic ADP-ribose.
Investigator(s):	Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	9th IUPAC International Symposium on Biomolecular Chemistry & 8th International Symposium for Chinese Medicinal Chemists (ISCMC-8) ; Mechanism of Calcium Signaling by CD38
Investigator(s):	Lee HC
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2012
Completion Date:	08/2012

List of Research Outputs

Jiang H., Sherwood R., Zhang S., Zhu X., Liu Q., Graeff R.M., Kriksunov I.A., Lee H.C., Hao Q. and Lin H.N., Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry, Analytical Biochemistry. 2013, 433: 218-226.

Moreau C., Liu Q., Graeff R.M., Wagner G.K., Thomas M.P., Swarbrick J.M., Shuto S., Lee H.C., Hao Q. and Potter B.V.L., CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template, PLoS ONE. 2013, 8: e66247.

Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.

Yu P., WANG Q., Zhang L.H., Lee H.C., Zhang L.R. and Yue J., A cell permeable NPE caged ADP-ribose for studying TRPM2, Plos One. 2012, 7(12): e51028.

Yu P., Zhang Z., Hao B., Zhao Y., Zhang L., Lee H.C., Zhang L. and Yue J., A novel fluorescent cell membrane permeable caged cyclic ADP-Ribose analogue, J Biol Chem. 2012, 287: 24774-24783.

Zhang H., Graeff R.M., Lee H.C. and Hao Q., Crystal Structures of Human CD38 in Complex with NAADP and ADPRP, Messenger . 2013, 2: 44-53.

Zhao Y., Lam M.C. and Lee H.C., Co-expression of two opposite orientations of CD38, Science Signaling. 2012.

Zhao Y., Lam M.C. and Lee H.C., The membrane-bound enzyme CD38 exists in two opposing orientations., In: Michael B. Yaffe, Sci Signal. . Washington DC, American Association for the Advancement of Science, 2012, 5 (241): ra67.

Researcher : Leung CFP

Project Title:	Regulation of CD38 in abscisic acid-activated human monocytes.
Investigator(s):	Leung CFP, Lee HC
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009

Researcher : Liao S

List of Research Outputs

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., Adrenomedullin as a biomarker for tubal ectopic pregnancy – new evidence from adrenomedullin function in the nasal ciliary epithelium. Society for Reproduction and fertility, Edinburgh, United Kingdom, #O019, July 2012.

Researcher : Lung MAKY

Project Title:	Endothelins in nasal mucosa: role in nasal congestion and decongestion
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Prostaglandin E receptors in the control of nasal patency.
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	05/2013

Researcher : Lung MKY

Project Title:	Endothelins in nasal mucosa: role in nasal congestion and decongestion
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Prostaglandin E receptors in the control of nasal patency.
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	05/2013

Researcher : Ma CW

Project Title:	The 42nd Annual Meeting of the Society for Neuroscience; Regulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor
Investigator(s):	Ma CW
Department:	School of Biological Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

List of Research Outputs

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., (Excellent Poster Presentation Award). Topographic organization of thalamic neurons responsive to rotational and translational head movements. Int'l Conference of Physiological Sciences 2012. , Acta Physiologica Sinica . 2012, 64: 245.

Chen W., Ma C.W., Hu H., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic transmission during a postnatal critical period alters behavior in path integration task, FAONS Symposia 2013. Melbourne, Australia. 2013.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function. 2013, 218: 833-850.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Chan Y.S. and Shum D.K.Y., Postnatal developmental profile of otolith-related inferior olivary neurons in rats. Int'l Conference of Physiological Sciences 2012 , Acta Physiologica Sinica. 2012, 64: 194.

Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic function in the central vestibular circuitry. Int’l Conference of Physiological Sciences 2012, The Chinese Association for Physiological Sciences Symposium - Synaptic Function and Plasticity in Health and Disease. Acta Physiologica Sinica . 2012, 64: 11.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets in postnatal maturation of vestibular behavior, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 70. 2013.

Ma C.W., Travel Award for International Congress of Physiological Sciences, The Physiological Society. 2013.

Researcher : Ng KP

List of Research Outputs

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., (Excellent Poster Presentation Award). Topographic organization of thalamic neurons responsive to rotational and translational head movements. Int'l Conference of Physiological Sciences 2012. , Acta Physiologica Sinica . 2012, 64: 245.

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., Topographic representation of thalamic neurons in head movement inputs, Abstracts of 8th Int’l Symp. on Healthy Aging: 62. 2013.

Researcher : Ng KP

List of Research Outputs

Chen W., Bai Z.T., Ng K.P., Ma C.W., Lai C.H. and Chan Y.S., Topographic representation of thalamic neurons in head movement inputs, Abstracts of 8th Int’l Symp. on Healthy Aging: 62. 2013.

Researcher : PAN J

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

PAN J., Xiao J., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces oxidative stress and apoptosis via angiotensin II receptor 1in the rat liver, 17^th Research Postgraduate Symposium, HKU, P2.29, 12/2012.

PAN J., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Telmisartan ameliorates oxidative stress and apoptosis in the liver of rats exposed to chronic intermittent hypoxia, The 16^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP7, 11/2012. Journal of the Hong Kong College of Cardiology, . 2012, 20(2):55.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

Researcher : Pan J

List of Research Outputs

Researcher : Ren L

Project Title:	Functional expression of sarcolemmal and mitochondrial KATP channels are a critical phenotypic determinant of human embryonic stem cell (hESC)-derived ventricular cardiomyocyte
Investigator(s):	Ren L, Li RA
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2013

Researcher : Shi W

List of Research Outputs

Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus, 11^th Biennial Meeting of Asia-Pacific Society of Neurochemistry Journal of Neurochemistry 123 (Suppl. 1): 80. 2012.

Shi W., Hu H., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates developmental plasticity of central vestibular synapses and vestibular behaviors in rats, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 60. 2013.

Researcher : Shiu SYW

Project Title:	Interactions between melatonin and NF-κB in the regulation of prostate cancer cell growth
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	02/2013

Project Title:	Interactions between androgen receptor (AR) and nuclear factor kappa B (NF-κB) signaling in prostate carcinogenesis
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Chong T.Y.I., Lee C.Y.L., Shiu S.Y.W. and Yao K.M., Using small molecules to induce the progressive differentiation of hESCs into pancreatic β-cell-like progenitors, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12, 2012.

Researcher : TAI WYE

List of Research Outputs

Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of neuregulin 1 type III in the EX vivo generation of fate committed Schwann cells from bone marrow stromal cells, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, December 12, 2012.

Leung K.K.H., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Neuregulin 1 type III in the switch of bone marrow stromal cells to fate-committed Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y. and Chan Y.S., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA), 131.11/A11 . 2012.

TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Notch signaling in differentiation of bone marrow-derived Schwann cells, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 64. 2013.

Researcher : Tai WYE

List of Research Outputs

Researcher : Tam KW

List of Research Outputs

Kwok L.F., KWAN P.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilized chondroitinase ABC I and II on chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 68. 2013.

Tam K.W., Chan Y.S. and Shum D.K.Y., The effects of chondroitinase ABC digestion products on neurite growth: Saccharide length and sulphation pattern, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 58. 2013.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers for culturing oriented Schwann cells to guide axonal growth, Abstracts of 8^th Int’l Symp. on Healthy Aging: How to age with finesse: 63. 2013.

Researcher : Tang F

Project Title:	Intermedin (adrenomedullin 2) in the testis: gene expression, physiological actions and regulation of secretion.
Investigator(s):	Tang F, O WS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010
Completion Date:	08/2012

Project Title:	Effects of adrenomedullin on fluid secretion in the oviduct and the seminal vesicle.
Investigator(s):	Tang F, Cheung KH, Chen J, O WS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

List of Research Outputs

Li L., Ma P., Liu Y., Huang C., O W.S., Tang F. and Zhang J.V., Intermedin attenuates LPS-induced inflammation in the rat testis, PLOS ONE. 2013, 8(6): e65278.

Liao S., Wong P.F., O W.S., Cheung B.M.Y. and Tang F., Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat, 2012, 31-37.

Liao S...B..., O W.S. and Tang F., Adrenomedullin inhibits norepinephrine-induced contraction in the rat seminal vesicle. , Urology 80, 224e.1-224e.5.. 2012.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., Adrenomedullin as a biomarker for tubal ectopic pregnancy – new evidence from adrenomedullin function in the nasal ciliary epithelium. Society for Reproduction and fertility, Edinburgh, United Kingdom, #O019, July 2012.

O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100(2): 459-463.

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the effects of intemedin on uterine contraction. Society for Reproduction and fertility, Edinburgh, United Kingdom, #P011, July 2012 . 2012.

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the ffects of intermedin on uterine contraction., Society for Reproduction and Fertility Abstract Series July 2012, #P011. 2012, 26.

Researcher : Ting KY

List of Research Outputs

Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.

Researcher : Tong CKB

List of Research Outputs

Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism Disrupted Capacitative Calcium Entry Familial Alzheimer’s Disease, Gordon Conference - Calcium Signalling 2013.

Tong C.K.B., Foskett J.K. and Cheung K.H., Mechanism of Capacitative Calcium Entry Deficits in PS1-Linked Familial Alzheimer’s Disease, 2013.

Researcher : WANG Q

List of Research Outputs

Yu P., WANG Q., Zhang L.H., Lee H.C., Zhang L.R. and Yue J., A cell permeable NPE caged ADP-ribose for studying TRPM2, Plos One. 2012, 7(12): e51028.

Researcher : WANG Y

List of Research Outputs

Jiang H., Khan S., Wang Y., Charron G., Sebastian C., Du J.T., Kim R., Ge E., Mostoslavsky R., Hang H.C., Hao Q. and Lin H.N., SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine, Nature. 2013, 496: 110-113.

WANG Y., Dutta S., Karlberg H., Devignot S., Weber F., Hao Q., Tan Y.J., Mirazimi A. and Kotaka M., STRUCTURE OF CRIMEAN-CONGO HAEMORRAGHIC FEVER VIRUS NUCLEOPROTEIN: SUPERHELICAL HOMO-OLIGOMERS AND THE ROLE OF CASPASE-3 CLEAVAGE, Journal of Virology. 2012, 86: 12294-303.

Researcher : WU F

List of Research Outputs

WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise ameliorates left ventricular hypertrophy induced by high fat diet in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P29, 3/2013.

Researcher : Wang Y

List of Research Outputs

Researcher : Wei W

List of Research Outputs

Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.

Researcher : Wong CW

List of Research Outputs

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the effects of intemedin on uterine contraction. Society for Reproduction and fertility, Edinburgh, United Kingdom, #P011, July 2012 . 2012.

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the ffects of intermedin on uterine contraction., Society for Reproduction and Fertility Abstract Series July 2012, #P011. 2012, 26.

Researcher : Wong PF

List of Research Outputs

Liao S., Wong P.F., O W.S., Cheung B.M.Y. and Tang F., Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat, 2012, 31-37.

Researcher : Wong TM

Project Title:	First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2000

Project Title:	XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2004

Project Title:	CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Researcher : Yeung WSB

Project Title:	Characterization of Stem/Progenitor Cells in Human Endometriosis
Investigator(s):	Yeung WSB, Chan RWS, Lee CKF, Luk JMC, Ng EHY
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	Role of microRNA let-7 in implantation of mouse blastocysts
Investigator(s):	Yeung WSB, Lee CKF, Liu W, Pang RTK
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Control of human extravillous cytotrophoblast invasion by adrenomedullin
Investigator(s):	Yeung WSB, Chiu CN
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	MicroRNA-135a induction transforms normal human papillomarvirus infected cervical cells into cells with cancer stem cell-like properties.
Investigator(s):	Yeung WSB, Pang RTK
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	12th International Conference on Preimplantation Genetic Diagnosis; Validation of a preimplantation genetic diagnosis protocol for double factor- alpha-thalassemia and reciprocal translocation
Investigator(s):	Yeung WSB
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

Researcher : Yu P

List of Research Outputs

Yu P., WANG Q., Zhang L.H., Lee H.C., Zhang L.R. and Yue J., A cell permeable NPE caged ADP-ribose for studying TRPM2, Plos One. 2012, 7(12): e51028.

Yu P., Zhang Z., Hao B., Zhao Y., Zhang L., Lee H.C., Zhang L. and Yue J., A novel fluorescent cell membrane permeable caged cyclic ADP-Ribose analogue, J Biol Chem. 2012, 287: 24774-24783.

Researcher : Yue J

Project Title:	Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and RNAi screen
Investigator(s):	Yue J, Lee HC
Department:	Physiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2009
Completion Date:	11/2012

Project Title:	Modulation of the neural lineage entry of mouse embryonic stem cells by the CD38/cADPR/Ca2+ signaling pathway
Investigator(s):	Yue J, Wu W
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Role of the CD38/cADPR/Ca2+ signaling pathway in cardiomyocyte differentiation of mouse embryonic stem cell
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	The role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells
Investigator(s):	Yue J, Wu W
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Molecular mechanisms of self-renewal and neuronal differentiation of neural stem cells
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	The Calcium Signaling Pathway Mediated by NAADP.
Investigator(s):	Yue J, Lee HC, Cheung KH
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Role of TRPM2/ADPR/Ca2+ signaling in self-renewal and neurogenesis of mouse neural stem cells
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	2013 ASBMB Annual Meeting; The NAADP/ TPC2/Ca2+ Signaling Antagonizes Autophagosome Maturation
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Wei W., Sun H., Ting K.Y., Zhang L.H., Lee H.C., Li G.R. and Yue J., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. , J Biol Chem. 2012, 287(42): 35599-611.

Yu P., WANG Q., Zhang L.H., Lee H.C., Zhang L.R. and Yue J., A cell permeable NPE caged ADP-ribose for studying TRPM2, Plos One. 2012, 7(12): e51028.

Yu P., Zhang Z., Hao B., Zhao Y., Zhang L., Lee H.C., Zhang L. and Yue J., A novel fluorescent cell membrane permeable caged cyclic ADP-Ribose analogue, J Biol Chem. 2012, 287: 24774-24783.

Yue J., Calcium, Stem Cells, Autophagy, and pH. ., Department of Chemical Pathology, Chinese University of Hong Kong. 2013.

Yue J., NAADP/TPC2/Ca2+ Signaling Inhibits Autophagosomal-Lysosomal Fusion by Alkalizing Lysosomal pH. , School of Biomedical Sciences, Chinese University of Hong Kong, . 2013.

Yue J., The Role of the NAADP/Two Pore Channel 2 (TPC2)/Ca2+ Signaling in the Maturation of Autophagosome, Ninth IUPAC International Symposium on Biomolecular Chemistry & Eighth International Symposium for Chinese Medicinal Chemists (ISCMC-8). 2012.

ZHANG Z.F., LU Y. and Yue J., Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells, Plos One. 2013, 8(6): e66077.

Researcher : ZHANG ZF

List of Research Outputs

ZHANG Z.F., LU Y. and Yue J., Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells, Plos One. 2013, 8(6): e66077.

Researcher : Zhang H

Project Title:	Interaction studies of CD38 with CD4 and anti-CD38 antibodies
Investigator(s):	Zhang H, Hao Q
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Structural study of virulence factor from Aspergillus fumigatus
Investigator(s):	Zhang H
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2013

List of Research Outputs

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of differic and ferro-bismuth bound human serum transferrin, 6th Asian Biological Inorganic Chemistry . 2012.

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of differic and ferro-bismuth bound human serum transferrin, 6^th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.

WANG M., Yang N., Zhang H., Hao Q. and Sun H., Structures of metal bound human serum transferrin reveal a partially-opened conformation in its N-lobe, Metals in Biology, Gordon Research Conferences. 2013.

Wang L., WANG M., Zhang H., Hao Q. and Sun H., Structural comparison of metal-bound human serum transferrin, 6th Asian Biological Inorganic Chemistry . 2012.

Wang L., WANG M., Zhang H., Hao Q. and Sun H., Structural comparison of metal-bound human serum transferrin, 6^th Asian Biological Inorganic Chemistry (AsBIC-VI). 2012.

Yang N., Zhang H., WANG M., Hao Q. and Sun H., Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe, Scientific Reports. Nature Publishing Group, 2012, 2: 999.

Zhang H., Graeff R.M., Lee H.C. and Hao Q., Crystal Structures of Human CD38 in Complex with NAADP and ADPRP, Messenger . 2013, 2: 44-53.

Zhou Y.Y., Zhang H., He B., Du J.T., Lin H.N., Cerione R.A. and Hao Q., The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5), Journal of Biological Chemistry. 2012, 287: 28307-28314.

Researcher : Zhao Y

Project Title:	Characteristics and potential regulatory mechanisms of a cytosolic CD38
Investigator(s):	Zhao Y, Lee HC
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

Project Title:	Antibody M-19 specifically recognizes intracellular CD38
Investigator(s):	Zhao Y, Lee HC, Hao Q
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2012

List of Research Outputs

Yu P., Zhang Z., Hao B., Zhao Y., Zhang L., Lee H.C., Zhang L. and Yue J., A novel fluorescent cell membrane permeable caged cyclic ADP-Ribose analogue, J Biol Chem. 2012, 287: 24774-24783.

Zhao Y., Lam M.C. and Lee H.C., Co-expression of two opposite orientations of CD38, Science Signaling. 2012.

Zhao Y., Lam M.C. and Lee H.C., The membrane-bound enzyme CD38 exists in two opposing orientations., In: Michael B. Yaffe, Sci Signal. . Washington DC, American Association for the Advancement of Science, 2012, 5 (241): ra67.

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