Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au LKS

Project Title:	EZH2 inhibition as a therapeutic strategy for hepatocellular carcinoma
Investigator(s):	Au LKS, Wong CM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

Project Title:	The American Association for Cancer Research Annual Meeting 2013; EZH2-mediated H3K27me3 is involved in epigenetic repression of DLC1 (Deleted in liver cancer 1) in human cancers
Investigator(s):	Au LKS
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013
Completion Date:	04/2013

List of Research Outputs

Au L.K.S., Ng I.O.L. and Wong C.M., Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins, Front Med. 2013, 7: 231-41.

Au L.K.S., Ng I.O.L. and Wong C.M., Regulation of EZH2 and its targeted microRNAs, In: Sarkar FH, Epigenetics and Cancer. Springer, 2013, 33-62.

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Frambach J.M., Driessen E.W., Beh S.L. and van der Vleuten C.P.M., Quiet Or Questioning? Students' Discussion Behaviors In Student-centered Education Across Culture, In: Lynn Meek V., Studies In Higher Education. UK, Taylor & Francis, 2013, 2013: 1-21.

Researcher : CHAN WL

List of Research Outputs

Millet J.K.G., Kien F.S., Cheung C.Y., Siu Y.L., CHAN W.L., Li H.Y., LEUNG H.L., Jaume M.D.A., Bruzzone R., Peiris J.S.M., Altmeyer R.M. and Nal-Rogier B.T.M., Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage, PLoS One. 2012, 7(11): e49566.

Researcher : Chan AYW

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Mak C.M., Lam C.W., Law C.Y., Siu C.W.K., Kwong L.L., Chan K.L., Chan W.T., Chow K.M., Lee K.W., Chan W.P. and Chan A.Y.W., Parental attitudes on expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Law CY, Siu WK, Kwong LL, Chan KL, Chan WT, Chow KM, Lee KW, Chan WP, Chan AY, Public Health. 2012, 126(11):954-9.

Siu C.W.K., Mak C.M., Siu S.L.Y., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular Diagnosis for a Fatal Case of Very Long-chain Acyl-CoA Dehydrogenase Deficiency in Hong Kong Chinese With a Novel Mutation: A Preventable Death by Newborn Screening , In: Wai-Kwan Siu, Chloe Miu Mak, Sylvia Luen-Yee Siu, Tak-Shing Siu, Chun-Yin Pang, Ching-Wan Lam, Ngan-Shan Kwong, Albert Yan-Wo Chan, Diagnostic Molecular Pathology. 2012.

Siu C.W.K., Mak C.M., Siu S.L., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular diagnosis for a fatal case of very long-chain acyl-CoA dehydrogenase deficiency in Hong Kong Chinese with a novel mutation: a preventable death by newborn screening, In: Siu WK, Mak CM, Siu SL, Siu TS, Pang CY, Lam CW, Kwong NS, Chan AY, Diagn Mol Pathol. 2012, 21(3):184-7.

Researcher : Chan GSW

List of Research Outputs

Chan G.S.W., Lam M.F., Kwan L., Fung S.H., Chan S.C. and Chan K.W., Clinicopathological study of renal biopsies after liver transplantation, Hong Kong Medical Journal. 2013, 19(1): 27-32.

Yung S.F., Cheung V.Y.T. and Chan G.S.W., Ovarian osteoma mimicking a teratoma on ultrasound, International Journal of Gynecology and Obstetrics. Elsevier Ireland Ltd, 2013, 121(Issue 3): 280-281.

Researcher : Chan KK

Project Title:	Autophagy in the chemoresistance of ovarian tumor-initiating cell
Investigator(s):	Chan KK, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	The role of BARX2 in esophageal squamous cell carcinoma
Investigator(s):	Chan KW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

Project Title:	The role of interleukin-8 (IL-8) and efficacy of IL-8 targeted therapy in CD133+ cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Chan KW, Ma SKY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Characterization and evaluation of neuropilin-2 (NRP2) as a novel oncogene in esophageal squamous cell carcinoma (ESCC)
Investigator(s):	Chan KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Chan D., Tsoi M.Y.T., Liu C.D., Chan S.H., Law S.Y.K., Chan K.W., Chan Y.P., Gopalan V., Lam A.K.Y. and Tang J.C.O., Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma, World Journal of Gastroenterology. 2013, 19(18): 2772-2780.

Chan G.S.W., Lam M.F., Kwan L., Fung S.H., Chan S.C. and Chan K.W., Clinicopathological study of renal biopsies after liver transplantation, Hong Kong Medical Journal. 2013, 19(1): 27-32.

Cheung A., Li B., Tsao G.S.W. and Chan K.W., Id1-induced IGF2 Promotes Tumor Angiogenesis by Paracrine Activation of Stromal Fibroblasts, In: Proceedings of the Meeting of the 22nd Biennial Congress of the European Association for Cancer Research; 2012 July 7-10; Barcelona, Spain. (EACR). 2012, 48 Supplement 5: S95.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung L.C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(5): 3009-3016.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(3): 1699-1706.

Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.

Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.

Yiu W.H., Leung J.C.K., Chan Y.Y., Chan K.W., Lan H.Y., Lai K.N. and Tang S.C.W., Activation of Protease-Activated Receptor 4 (PAR-4) in Tubular Epithelial Cells Contributes to Diabetic Nephropathy, J Am Soc Nephrol. 2012, 23: 1036A.

Yuen H.F., Abramczyk O., Montgomery G., Chan K.K., Huang Y.H., Sasazuki T., Shirasawa S., Srivastava G., Chan K.W., Fennell D., Janne P., El-Tanani M. and Murray J.T., Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells, Biosci Rep. 2012, 32(4): 413-22.

Researcher : Chan LC

Project Title:	To develop a pilot humanities program in the first year undergraduate medical curriculum 2007-2008.
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	08/2007

Project Title:	The 7th Asia Pacific IAP Congress 2011 Professionalism and the practice of Pathology - Key Issues and Challenges
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2011

Project Title:	King's/HKU Fellowship Awards 2011-12
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	09/2011

Project Title:	7th Conference on the Asian Medical Education Association; How do we assess humanistic qualities in medical education
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Chan L.C., (1) Speaker, Symposium on “Students as Partners in Learning” – Title “How learning with and from students makes for a better teacher”. (2) Chief Judge for Free Communication Session: Student/Trainee Affairs, 10th Asia Pacific Medical Education Conference (APMEC). Singapore (16-20 January 2013). 2013.

Chan L.C., Chapter 8: Mindfulness to Enhance Teaching and Learning, Cases on Quality Teaching Practices in Higher Education. IGI Global, 2013, 119-130.

Chan L.C., Speaker, Plenary Session “Student Assessment” - Title “How do we assess humanistic qualities in medical education” , 7th Symposium of the Asian Medical Education Association. Ulaanbaatar, Mongolia. (9-12 June 2013) . 2013.

Chan L.C., Speaker, Symposium on “Diversities of / in PBL: commitment, change and compromise” - Title “PBL and Student/Professional Diversity in Higher Education – A HKU Experience” , 2nd Asia Pacific Joint Conference on PBL 2012. Shanghai (24-28 October 2012). 2012.

Chan L.C., Speaker, Symposium on “Peace and Health: Health Professionals in Peace, Conflict Healing: Impact on the Vulnerable Women and Children” – Title “How medical education can promote peace and health”. , 44th Asia Pacific Academic Consortium for Public Health. Sri Lanka (14-17 October 2012). 2012.

Chan L.C., Speaker, To speak on patients’ perspective at the Roundtable on Healthcare Communication, 2nd Symposium on Healthcare Communication, Hong Kong Polytechnic University (25 June 2013) . 2013.

Chen J.Y., Chan L.K., Lam C.L.K. and Chan L.C., Medical student perception of suffering in the early clinical years, Medical Education. 2012, 46 (s2): 12-13.

Frambach J.M., Driessen E.W., Chan L.C. and van der Vleuten C.P.M., Rethinking the globalisation of problem-based learning: how culture challenges self-directed learning, Medical Education. 2012, 46(8): 738-747.

LAM Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in normal mouse hematopoietic stem cells and leukemic cells, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

ZHANG J., Ng R.K. and Chan L.C., Functions of JARID1B in the Regulation of Hematopoiesis and Leukemogenesis, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

Researcher : Chan LK

Project Title:	Molecular dissection of the functional association of the PTEN and DLC1 tumor suppressors
Investigator(s):	Chan LK, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Shum C.K., Lau C.S.T., TSOI L.S., Chan L.K., Yam J.W.P., Ohira M., Nakagawara A., Tam P.K.H. and Ngan E.S.W., Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation., Oncogene. 2012, doi: 10.1038/onc.2012.437.

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

Researcher : Chan VSF

Project Title:	Development of a humanized mouse systemic lupus erythematosus model for studying disease pathogenesis and evaluation of therapeutic treatment efficacy
Investigator(s):	Chan VSF
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Functional characterization of the novel C-type lectin-like receptor CLEC16A and its expression association in systemic lupus erythematosus
Investigator(s):	Chan VSF, Lau WCS
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Molecular profiling of pathogenic dendritic cells development in systemic lupus erythematosus
Investigator(s):	Chan VSF
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Chan V.S.F., Tsang H.L., Tam C.Y., Lu L. and Lau W.C.S., B-cell-targeted therapies in systemic lupus erythematosus., Cellular & Molecular Immunology. 2013, 10(2): 133-42.

Chan V.S.F., Plasmacytoid dendritic cells and SLE, Kaohsiung Medical University. 2012.

Chan V.S.F., Systemic Lupus Erythematosus:Insights from animal models, Kaohsiung Medical University. 2012.

Chen Y., Hwang S.Y., Chan V.S.F., Chung P.Y., Wang S.R., Li Z., Ma J., Lin C.W., Hsieh Y.J., Chang K.P., Kung S.S., Wu Y.C., Chu C.W., Tai H.T., Gao G.F., Zheng B., Yokoyama K.K., Austyn J.M. and Lin C.L., Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells, PLoS Pathogen. 2013, 9(1): e1003100.

Researcher : Chan WY

Project Title:	The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract
Investigator(s):	Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011

Project Title:	Neutrophil mediated host-responses during influenza A virus infection, an in vitro study
Investigator(s):	Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

Project Title:	Human primary lung microvascular endothelial responses to influenza A virus infection
Investigator(s):	Chan WY, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	Annual World Congress of Virus andInfection (WCVI-2012) Influenza virus tropism in human respiratory tract
Investigator(s):	Chan WY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	08/2012

Project Title:	The application of swine and human respiratory organ explant cultures to investigate inter-species transmission of avian influenza viruses to swine and humans
Investigator(s):	Chan WY, Chan MCW, Nicholls JM, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Influenza B virus induced host innate immune response in human primary alveolar epithelial cells
Investigator(s):	Chan WY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Chan M.C.W., Chan W.Y., Leung C.Y.H., Fang X., Nicholls J.M., Lee J., Matthay M.A. and Peiris J.S.M., Effect of human mesenchymal stem cells on enhancing alveolar fluid clearance in human alveolar epithelium injured by influenza H5N1 virus infection, 6th Annual CEIRS Network Meeting . 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus pathogenesis in human respiratory epithelial cell , The Pulmonary Centre, Boston University School of Medicine. 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus tropism in human and swine respiratory tract, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, US . 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus tropism in human respiratory tract, 3rd Annual World Congress of Virus and Infection. 2012.

Chan W.Y. and Poon L.L.M., The emergence of human coronavirus EMC: how scared should we be?, mBio. 2013, 4(2): e00191-13.

LEUNG H.S., LI O.T., Chan W.Y., CHAN M.C., Nicholls J.M. and POON L.L., The virus entry of influenza A virus with a α2,6-linked sialic acid binding preference requires host fibronectin, In: Leung HS, Li OT, Chan RW, Chan MC, Nicholls JM, Poon LL, J Virol. 2012.

Leung S.Y.H., Li O.T.W., Chan W.Y., Chan M.C.W., Nicholls J.M. and Poon L.L.M., Entry of influenza A Virus with a alpha2,6-linked sialic acid binding preference requires host fibronectin, Journal of virology. 2012, 86(19): 10704-13.

WONG D.D.Y., Choy K.T., Chan W.Y., Sia S.F., Chiu H.P., CHEUNG P.H.P., Chan M.C.W., Peiris J.S.M. and Yen H., Comparable Fitness and Transmissibility between Oseltamivir- Resistant Pandemic 2009 and Seasonal H1N1 Influenza Viruses with the H275Y Neuraminidase Mutation, Journal of Virology. 10570, 2012, 86: 10558.

Researcher : Chan YK

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

List of Research Outputs

Ma X., Beeghly-Fadiel A., Lu W., Shi J., Xiang Y.B., Cai Q., Shen H., Shen C.Y., Ren Z., Matsuo K., Khoo U.S., Iwasaki M., Long J., Zhang B., Ji B.T., Zheng Y., Wang W., Hu Z., Liu Y., Wu P.E., Shieh Y.L., Wang S., Xie X., Ito H., Kasuga Y., Chan Y.K., Iwata H., Tsugane S., Gao Y.T., Shu X.O., Moses H.L. and Zheng W., Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians, Cancer Epidemiol Biomarkers Prev. 2012, 21(7): 1176-84.

Researcher : Chan YP

List of Research Outputs

Chan D., Tsoi M.Y.T., Liu C.D., Chan S.H., Law S.Y.K., Chan K.W., Chan Y.P., Gopalan V., Lam A.K.Y. and Tang J.C.O., Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma, World Journal of Gastroenterology. 2013, 19(18): 2772-2780.

Fung T.M., Kwan P.S., Tong M., Chan Y.P., Guan X. and Ma S.K.Y., RNA-Seq identifies neuropilin-2 as a novel oncogene in esophageal squamous cell carcinoma, The American Association for Cancer Research - Annual Meeting. 2013.

Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.

Tong M., Kwan P.S., Chan Y.P., Lin C., Lok S., Guan X. and Ma S.K.Y., Annexin A3 confers both cancer and stem cell-like properties in CD133+ liver cancer-initiating cells, The Hong Kong International Cancer Congress. 2012.

Researcher : Chen SPL

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

Project Title:	Anti-tumor effects of IL2Rα (CD25) antagonists, either as single agents or in combination with a proteasome inhibitor, Bortezomib in NK-cell malignancies
Investigator(s):	Chen WYW, Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Cervical cancer screening by enhanced cervical cytology-application of novel markers
Investigator(s):	Cheung ANY, Ngan HYS, Guan X
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2007

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2009

Project Title:	DOCK180 in ovarian cancer progression
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	p21-activated kinase 4 in chemosensitivity of ovarian cancer
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	FBI-1 (Pokemon) in Gestational Trophoblastic Disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY, Wong GW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Tumour Microenvironment - New concepts and molecular mechanisms
Investigator(s):	Cheung ANY, Ng IOL, Khoo US, Lung ML, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	01/2012

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Apoptosis stimulating proteins of p53 and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

Chan R.W., Mak A.S., Yeung W.S., Lee K.F., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S., Human female reproductive tract epithelial cell culture, In: Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, Lam EW, Chan KK, Ngan HY, Le XF, Cheung AN, Methods Mol Biol. 2012.

Chan R.W.S., Mak A.S.C., Yeung W.S.B., Lee C.K.F., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., Human Female Reproductive Tract Epithelial Cell Culture. In: Epithelial Cell Culture Protocols: Second Edition, Methods in Molecular Biology, vol. 945, Chapter 21., Scott H. Randell and M. Leslie Fulcher . 2013, 945: Ch21.

Cheung A.N.Y., - Basis, terminology and reporting system of gynaecological cytology - Glandular cell abnormalities in cervical cytology - Diagnostic problems and mimickers in cervical cytology - Automation in cervical cytology - Application of new laboratory techniques including HPV testing, CME Seminar on Cervical cytology and HPV test, organized by HKU-Shen Zhen Hospital, June 22-23, 2013, Shenzhen, China. 2013.

Cheung A.N.Y., 1. Automated screening 2. Evolution of automated screening 3. HPV oncogenes and cervical carcinogenesis, Invited plenary speaker on in Asia Oceania (research organisation on) Genital Infections & Neoplasia (AOGIN), Hong Kong, July 13-15, 2012 . 2012.

Cheung A.N.Y., Cervical Cancer Prevention and Screening in Developing Countries, International Conference on Clinico-Histopathology. 7-8 Nov 2012. Calmette Hospital, Phnom Penh, Cambodia, organized by the International Academy of Pathology, University of Health Science and Calmette Hospital, Cambodia. 2012.

Cheung A.N.Y. and Ngan H.Y.S., Fallopian tube cancer, In: Cheung AN, Ngan HY, Clinical Gynecology, 2nd Edition (In press). Cambridge University Press, 2013.

Cheung A.N.Y., Wang X. and Zhao C., Gyaneoclogical and clinical cytology, In: Zheng Wenxin, Pathology of Obstetrics and Gynecology (In Press). Peoples’ Health Publishing House, 2013.

Cheung A.N.Y., Highlights on New Classification of Gynaecological Tumours, 10th National Obstetrics and Gynaecology Meeting, 3-5 Nov 2012, Xiamen, China. 2012.

Cheung A.N.Y., Invited speaker on “Cervical Cancer Screening after Introduction of HPV vaccine”, Asia Oceania (research organisation on) Genital Infections & Neoplasia (AOGIN), Kunming, April 26-28, 2013. 2013.

Cheung A.N.Y., Invited speaker on “Pathology of uterine smooth muscle tumour”, 11th National Obstetrical Gynaecological Pathology Meeting, Jinan, China, 24-27 May 2013. 2013.

Cheung A.N.Y., Invited speaker on “Possible standardization of the lower anogenital squamous terminology", 10th Nationwide Cervical precancerous lesions and cervical cancer Seminar on topical issues, organized by Peking University People’s Hospital, April 19-21 2013, Beijing, China. 2013.

Cheung A.N.Y., Invited speaker on “Quality Assurance in non-Gynaecological Cytology” and “Urine Cytology”, 广东省病理质量控制会议 Pathology Quality Control Conference of Guangdong Province in 2013年广东省细胞病理学培训班organized by广东省临床病理质量控制中心 Clinical Pathology Quality Control Center of Guangdong Province, Sun Yat Sen University, June 28-30, 2013, Penyu, China. 2013.

Cheung A.N.Y., Pathology of genital tract and breast, In: Wang LT, National College Planned Textbook of Medicine – Pathology 2nd Edition (125 Planned national text book) (In Press). Beijing Higher Education Press, 2013.

Cheung S.Y.C., Liu S., Ip P.P.C., Cheung A.N.Y. and Ngan H.Y.S., GENETIC AMPLIFICATION OF PIK3CA IN VULVAR SQUAMOUS CELL CARCINOMA, Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, Hong Kong. 2012.

Jiang L. and Cheung A.N.Y., Molecular biology and genetic application in gynecologic pathology, In: Zheng Wenxin, Pathology of Obstetrics and Gynecology (In Press). Peoples’ Health Publishing House, 2013.

Khoo U.S. and Cheung A.N.Y., Cervical Screening in Hong Kong, Present and Future, 18th International Congress of Cytology, Paris. 2013.

Khoo U.S. and Cheung A.N.Y., Cervical Screening in Hong Kong, Present and Future, 18th International Congress of Cytology, Paris, 2013.. 2013.

Kwan H.T., Chan D.W., Cai C., Mak S.L., Yung M.H., Leung T.H.Y., Wong G.W., Cheung A.N.Y. and Ngan H.Y.S., AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity, PLoS ONE. 2013, 8: e53597.

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., MicroRNA-135a regulates cervical cancer transformation and progression through ß-catenin via a SIAH1-dependent ubiquitin-proteosomal pathway, The 19th Hong Kong International Cancer Congress. 2012.

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., Role of microRNA-135a in cervical cancer transformation and development., The 17th Research Postgraduate Symposium. 2012.

LEUNG T.W., Liu S., Cheung A.N.Y. and Ngan H.Y.S., Methylation status at HPV16 E2 binding sites is a potential molecular marker for monitoring patients with Cervical Intraepithelial Neoplasia (CIN), 28th International Papillomavirus Conference, San Juan, Puerto Rico, Nov 30 – Dec 6, 2012. . 2012.

Leung T.W., Liu S., Chan A.N.H., Cheung A.N.Y. and Ngan H.Y.S., EXPRESSION OF NOTCH 1 PROTEIN IN CERVICAL CANCER AND CERVICAL PREMALIGNANT LESIONS AND ITS CORRELATION WITH HUMAN PAPILLOMAVIRUS (HPV) INFECTION AND CLINICAL PARAMETERS , Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, Hong Kong. 2012.

Liu S., Ng E.K.O., Leung C.Y., Cheung A.N.Y., Kwong A. and Ngan H.Y.S., ALTERED MICRORNA EXPRESSION ASSOCIATED WITH HUMAN PAPILLOMAVIRUS (HPV) INFECTION IN CERVICAL CANCER , Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, Hong Kong. 2012.

Liu S., Ng E.K.O., Leung C.Y., Cheung A.N.Y., Kwong A. and Ngan H.Y.S., Aberrant miRNA expressions associated with Human Papillomavirus (HPV) infection contribute to cervical carcinogenesis , 28th International Papillomavirus Conference, Puerto Rico, Nov.30-Dec. 6, 2012.

Mak C.Y., Lee L., Siu K.Y., Wong G.W., Lu X., Ngan H.Y.S., Wong E.S. and Cheung A.N.Y., Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation , Carcinogenesis. 2013, June 2013.

Mak C.Y., Siu K.Y., Wong G.W., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., Dysregulated stemness-related genes in gynecological malignancies., Histology and histopathology. 2012, 27: 1121-1130.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., Adrenomedullin as a biomarker for tubal ectopic pregnancy – new evidence from adrenomedullin function in the nasal ciliary epithelium. Society for Reproduction and fertility, Edinburgh, United Kingdom, #O019, July 2012.

O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100(2): 459-463.

Siu K.Y., Kong D.S., Chan H.Y., Wong E.S.Y., Ip P.P.C., Jiang L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome, In: Siu MK, Kong DS, Chan HY, Wong ES, Ip PP, Jiang L, Ngan HY, Le XF, Cheung AN, PLoS One. 2012.

Siu M.K., Wong E.S.Y., Kong D.S., Chan H.Y., Jiang L., Wong G.W., Lam E.W., Chan K.K., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers, In: Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, Lam EW, Chan KK, Ngan HY, Le XF, Cheung AN, Oncogene. 2012.

Wong G.W., Wong I.T., Chu T.C., Ngan H.Y.S. and Cheung A.N.Y., Dysregulation of miR-143 in cervical cancer, AOGIN 2012.

Xue W.C. and Cheung A.N.Y., Complications of early pregnancy, including trophoblastic neoplasia, In: Zheng Wenxin, Pathology of Obstetrics and Gynecology (In Press). Peoples’ Health Publishing House, 2013.

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

Researcher : Cheung FMF

List of Research Outputs

Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.

Researcher : Cheung YN

Project Title:	Examination of eIF4E level in human breast cancers and study the role of eIF4E in regulating translation of various splice variants of breast cancer genes
Investigator(s):	Cheung YN, Khoo US, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2010

List of Research Outputs

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

Researcher : Ching DCK

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Tsang J.P., Poon W.L., Luk H.M., Fung C.W., Ching D.C.K., Mak C.M., Lam C.W., Siu T.S., Tam S. and Wong V.C., Arginase deficiency with new phenotype and a novel mutation: contemporary summary, In: Tsang JP, Poon WL, Luk HM, Fung CW, Ching CK, Mak CM, Lam CW, Siu TS, Tam S, Wong VC, Pediatr Neurol. 2012, 47(4):263-9.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2013

Project Title:	Regulation of p53 by PAK4 in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER; Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Researcher : Chiu PM

List of Research Outputs

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.

Researcher : Chiu YT

Project Title:	Dissecting the gender disparity of hepatocellular carcinoma - Roles of androgen receptor signaling in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	AACR Annual Meeting 2013; Dissecting the gender disparity of hepatocellular carcinoma - Roles of HBV X protein and androgen receptor
Investigator(s):	Chiu YT
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Chiu Y.T., Dissecting the gender disparity of hepatocellular carcinoma - Roles of HBV X protein and androgen receptor , AACR Annual Meeting 2013.

Chiu Y.T., Tang K., Wong Y.C. and Ling M.T., Inactivation Of Atm/atr Dna Damage Checkpoint Promotes Androgen Induced Chromosomal Instability In Prostate Epithelial Cells., Plos One. 2012, 7(12): e51108.

Researcher : Choi WL

Project Title:	Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):	Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:	Pathology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	04/2011

Project Title:	Identification of FOXP1 target genes in diffuse large B-cell lymphoma
Investigator(s):	Choi WL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012
Completion Date:	01/2014

List of Research Outputs

Choi W.L., A 66-year-old male with massive splenomegaly, UCLA-HKS&H Lymphoma Conference 2013. 2013.

Hu S., Xu-Monette Z.Y., Balasubramanyam A., Manyam G.C., Visco C., Tzankov A., Liu W.M., Miranda R.N., Zhang L., Montes-Moreno S., Dybkaer K., Chiu A., Orazi A., Zu Y., Bhagat G., Richards K.L., Hsi E.D., Choi W.L., van Krieken J.H., Huang Q., Huh J., Ai W., Ponzoni M., Ferreri A.J., Zhao X., Winter J.N., Zhang M., Li L., Moller M.B., Piris M.A., Li Y., Go R.S., Wu L., Medeiros L.J. and Young K.H., CD30 expression defines a novel subset of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from The International DLBCL Rituximab-CHOP Consortium Program Study, Blood. 2013.

Hu S., Xu-Monette Z.Y., Tzankov A., Green T., Wu L., Balasubramanyam A., Liu W.M., Visco C., Li Y., Miranda R.N., Montes-Moreno S., Dybkaer K., Chiu A., Orazi A., Zu Y., Bhagat G., Richards K.L., Hsi E.D., Choi W.L., Zhao X., van Krieken J.H., Huang Q., Huh J., Ai W., Ponzoni M., Ferreri A.J., Zhou F., Slack G.W., Gascoyne R.D., Tu M., Variakojis D., Chen W., Go R.S., Piris M.A., Moller M.B., Medeiros L.J. and Young K.H., MYC/BCL2 protein co-expression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program Study, Blood. 2013.

Li Y., Gordon M.W., Xu-Monette Z.Y., Visco C., Tzankov A., Zou D., Qiu L., Montes-Moreno S., Dybkaer K., Orazi A., Zu Y., Bhagat G., Richards K.L., Hsi E.D., Choi W.L., van Krieken J.H., Huang Q., Ai W., Ponzoni M., Ferreri A.J., Winter J.N., Go R.S., Piris M.A., Moller M.B., Wu L., Wang M., Ramos K.S., Medeiros L.J. and Young K.H., Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program, Blood. 2013.

Love C., Sun Z., Jima D., Li G., Zhang J., Miles R., Richards K.L., Dunphy C.H., Choi W.L., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Chadburn A., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Greenough A., Moffitt A.B., McKinney M., Banerjee A., Grubor V., Levy S., Dunson D.B. and Dave S.S., The genetic landscape of mutations in Burkitt lymphoma, Nat Genet. 2012, 44(12): 1321-5.

Love C.L., Jima D., Sun Z., Miles R.R., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K., Evens A.M., Chadburn A., Gordon L.I., Czader M., Gill J., Hsi E.D., Zhang J., Grubor V., Levy S., Bunerjee A., Dunson D., Li G., Moffitt A., Greenough A., McKinney M.S. and Dave S.S., ID3 is a novel tumor suppressor gene in Burkitt lymphoma, The 54th American Society of Hematology Annual Meeting and Exposition. 2012.

Madadi A., Raghavendra M., Hu S., Xu-Monette Z.Y., Visco C., Tzankov A., Montes-Moreno S., Dybkaer K., Chiu A., Orazi A., Zu Y., Bhagat G., Dunphy C.H., Hsi E.D., Zhao F.X., Choi W.L., Zhao X., Van Krieken J.H.J.M., Huh J., Huang Q., Ai W., Ponzoni M., Ferreri A.J.M., Zhou F., Winter J.N., Piris M., Møller M.B., Medeiros L.J., Go R.S. and Young K.H., Prognostic significance and phenotypic manifestations of MYC/BCL2 protein expression in diffuse large B-cell lymphoma (DLBCL) with extranodal organ involvement: a report of the International DLBCL Rituximab-CHOP Consortium Program Study, The 54th American Society of Hematology Annual Meeting and Exposition . 2012.

Meyer C., Hofmann J., Burmeister T., Groger D., Park T.S., Emerenciano M., Pombo de Oliveira M., Renneville A., Villarese P., Macintyre E., Cave H., Clappier E., Mass-Malo K., Zuna J., Trka J., De Braekeleer E., De Braekeleer M., Oh S.H., Tsaur G., Fechina L., van der Velden V.H., van Dongen J.J., Delabesse E., Binato R., Silva M.L., Kustanovich A., Aleinikova O., Harris M.H., Lund-Aho T., Juvonen V., Heidenreich O., Vormoor J., Choi W.L., Jarosova M., Kolenova A., Bueno C., Menendez P., Wehner S., Eckert C., Talmant P., Tondeur S., Lippert E., Launay E., Henry C., Ballerini P., Lapillone H., Callanan M.B., Cayuela J.M., Herbaux C., Cazzaniga G., Kakadiya P.M., Bohlander S., Ahlmann M., Choi J.R., Gameiro P., Lee D.S., Krauter J., Cornillet-Lefebvre P., Te Kronnie G., Schafer B.W., Kubetzko S., Alonso C.N., Zur Stadt U., Sutton R., Venn N.C., Izraeli S., Trakhtenbrot L., Madsen H.O., Archer P., Hancock J., Cerveira N., Teixeira M.R., Lo Nigro L., Moricke A., Stanulla M., Schrappe M., Sedek L., Szczepanski T., Zwaan C.M., Coenen E.A., van den Heuvel-Eibrink M.M., Strehl S., Dworzak M., Panzer-Grumayer R., Dingermann T., Klingebiel T. and Marschalek R., The MLL recombinome of acute leukemias in 2013, Leukemia. 2013.

So J.C.C., Choi W.L. and Kwong Y.L., Pure red cell aplasia associated with CD20+ myeloma: complete remission with rituximab, Ann Hematol. 2013.

Visco C., Tzankov A., Xu-Monette Z.Y., Miranda R.N., Tai Y.C., Li Y., Liu W.M., d'Amore E.S., Montes-Moreno S., Dybkaer K., Chiu A., Orazi A., Zu Y., Bhagat G., Wang H.Y., Dunphy C.H., Hsi E.D., Zhao X.F., Choi W.L., Zhao X., van Krieken J.H., Huang Q., Ai W., O'Neill S., Ponzoni M., Ferreri A.J., Kahl B.S., Winter J.N., Go R.S., Dirnhofer S., Piris M.A., Moller M.B., Wu L., Medeiros L.J. and Young K.H., Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study, Haematologica. 2013, 98(2): 255-63.

Xu-Monette Z.Y., Wu L., Visco C., Tai Y.C., Tzankov A., Liu W.M., Montes-Moreno S., Dybkaer K., Chiu A., Orazi A., Zu Y., Bhagat G., Richards K.L., Hsi E.D., Zhao X.F., Choi W.L., Zhao X., van Krieken J.H., Huang Q., Huh J., Ai W., Ponzoni M., Ferreri A.J., Zhou F., Kahl B.S., Winter J.N., Xu W., Li J., Go R.S., Li Y., Piris M.A., Moller M.B., Miranda R.N., Abruzzo L.V., Medeiros L.J. and Young K.H., Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study, Blood. 2012, 120(19): 3986-96.

Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D. and Dave S.S., Genetic heterogeneity of diffuse large B-cell lymphoma, Proc Natl Acad Sci U S A. 2013, 110(4): 1398-403.

Researcher : Chow MYP

List of Research Outputs

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.

Researcher : Chu KY

List of Research Outputs

Sze M.F., Chu K.Y., Lee M.F. and Ng I.O.L., C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma, Hepatology. 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, has suppressive role in mitotic checkpoint signaling in hepatocellular carcinoma, 19th Hong Kong International Cancer Congresss . 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, suppresses mitotic checkpoint signaling in hepatocellular carcinoma, American Association for Cancer Research Annual Meeting 2013.

Researcher : Deng J

List of Research Outputs

Deng J., Yang M., Liu Y., Wang X., Ko K.H. and Lu L., Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Reply, Arthritis Rheum. 2013, 65(1): 285-7.

Deng J., Liu Y., Yang M., Wang S., Zhang M., Wang X., Ko K.H., Hua Z., Sun L., Cao X. and Lu L., Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response, Arthritis Rheum. 2012, 64(11): 3564-73.

Researcher : Fan NY

List of Research Outputs

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Researcher : GONG C

List of Research Outputs

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

Researcher : Ho DWH

Project Title:	Joint Conference of HGM 2013 and 21st International Congress of Genetics; PATHWAY ANALYSIS OF GENOME-WIDE ASSOCIATION DATA ON HEPATOCELLULAR CARCINOMA IN SOUTHERN CHINESE PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION
Investigator(s):	Ho DWH
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

List of Research Outputs

Consortium of refractive error and myopia .. and Ho D.W.H., Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia, Nature Genetics. 2013.

Ho D.W.H., Wong C.M., Sham P.C. and Ng I.O.L., Pathway analysis of genome-wide association data on hepatocellular carcinoma in southern Chinese patients with chronic hepatitis B virus infection., Joint Conference of HGM 2013 and 21st International Congress of Genetics.. 2013.

Kwok T., Wong A., Chan G., Shiu Y.Y., Lam K.C., Young D., Ho D.W.H. and Ho F., Effectiveness of cognitive training for Chinese elderly in Hong Kong., Clinical Interventions in Aging. 2013.

Researcher : Hopton CL

List of Research Outputs

Walther T.J., Karamanska R., Chan W.Y., Chan M.C.W., Jia N., Air G., Hopton C.L., Wong M.P., Dell A., Peiris J.S.M., Haslam S.M. and Nicholls J.M., Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection, PLoS Pathogen. 2013, 9(3): e1003223.

Researcher : Ip PPC

List of Research Outputs

Cheung S.Y.C., Liu S., Ip P.P.C., Cheung A.N.Y. and Ngan H.Y.S., GENETIC AMPLIFICATION OF PIK3CA IN VULVAR SQUAMOUS CELL CARCINOMA, Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, Hong Kong. 2012.

Seto W.K.W., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., Yuen J.C.H., Hung I.F.N., Lai C.L. and Yuen R.M.F., High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B., PLoS One. 2012, 7(8): e43087.

Siu K.Y., Kong D.S., Chan H.Y., Wong E.S.Y., Ip P.P.C., Jiang L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome, In: Siu MK, Kong DS, Chan HY, Wong ES, Ip PP, Jiang L, Ngan HY, Le XF, Cheung AN, PLoS One. 2012.

Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Ip P.P.C., Huang F.Y., Lai C.L. and Yuen R.M.F., Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency, Clin Gastroenterol Hepatol. 2013, 11: 1004-10.

Researcher : Ip WK

List of Research Outputs

Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.

Researcher : Ip YC

Project Title:	Targeting Granulin for Breast Cancer Therapy
Investigator(s):	Ip YC, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008

Researcher : Kai KLA

List of Research Outputs

Wong C.M., Kai K.L.A., Tsang F.H. and Ng I.O.L., Regulation of hepatocarcinogenesis by microRNAs., Front Biosci (Elite Ed). 2013, 5: 49-60.

Researcher : Kan J

Project Title:	The possible role and function of a histone H3K4 demethylase, JARID1B in defining colorectal cancer stem cells
Investigator(s):	Kan J, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	09/2012

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):	Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Characterization of candidate microRNAs associated with Tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Cheung YN
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

Project Title:	The role of eIF4E in regulating translation of splice variants of breast cancer related genes
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	Role of eIF4E in tamoxifen resistance in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	18th International Congress of Cytology; Cervical Screening in Hong Kong, Present and Future
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

Project Title:	Antibody specific splice variant as biomarker for tamoxifen responsiveness in breast cancer
Investigator(s):	Khoo US, Man PS
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

List of Research Outputs

Chen H.W., Du C.W., Wei X.L., Khoo U.S. and Zhang G.J., Cytoplasmic CXCR4 high-expression exhibits distinct poor clinicopathological characteristics and predicts poor prognosis in triple-negative breast cancer, Curr Mol Med. 2013, 13(3): 410-6.

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

Gong C. and Khoo U.S., Nuclear Localization Marker of FOXO3a: Can it be Used to Predict Doxorubicin Response?, Front Oncol. 2013, 3: 149.

Khoo U.S., Breast Pathology: Refining Breast Cancer Taxomony in the 21st Century, Hong Kong Pathology Forum 2013. 2013.

Khoo U.S. and Cheung A.N.Y., Cervical Screening in Hong Kong, Present and Future, 18th International Congress of Cytology, Paris. 2013.

Khoo U.S. and Cheung A.N.Y., Cervical Screening in Hong Kong, Present and Future, 18th International Congress of Cytology, Paris, 2013.. 2013.

Ma X., Beeghly-Fadiel A., Lu W., Shi J., Xiang Y.B., Cai Q., Shen H., Shen C.Y., Ren Z., Matsuo K., Khoo U.S., Iwasaki M., Long J., Zhang B., Ji B.T., Zheng Y., Wang W., Hu Z., Liu Y., Wu P.E., Shieh Y.L., Wang S., Xie X., Ito H., Kasuga Y., Chan Y.K., Iwata H., Tsugane S., Gao Y.T., Shu X.O., Moses H.L. and Zheng W., Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians, Cancer Epidemiol Biomarkers Prev. 2012, 21(7): 1176-84.

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

Zheng W., Zhang B., Cai Q., Sung H., Michailidou K., Shi J., Choi J.Y., Long J., Dennis J., Humphreys M.K., Wang Q., Lu W., Gao Y.T., Li C., Cai H., Park S.K., Yoo K.Y., Noh D.Y., Han W., Dunning A.M., Benitez J., Vincent D., Bacot F., Tessier D., Kim S.W., Lee M.H., Lee J.W., Lee J.Y., Xiang Y.B., Zheng Y., Wang W., Ji B.T., Matsuo K., Ito H., Iwata H., Tanaka H., Wu A.H., Tseng C.C., Van Den Berg D., Stram D.O., Teo S.H., Yip C.H., Kang I.N., Wong T.Y., Shen C.Y., Yu J.C., Huang C.S., Hou M.F., Hartman M., Miao H., Lee S.C., Putti T.C., Muir K., Lophatananon A., Stewart-Brown S., Siriwanarangsan P., Sangrajrang S., Shen H., Chen K., Wu P.E., Ren Z., Haiman C.A., Sueta A., Kim M.K., Khoo U.S., Iwasaki M., Pharoah P.D., Wen W., Hall P., Shu X.O., Easton D.F. and Kang D., Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls, Hum Mol Genet. 2013, 22(12): 2539-50.

Researcher : Ko FCF

Project Title:	Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Researcher : Ko KH

List of Research Outputs

Deng J., Yang M., Liu Y., Wang X., Ko K.H. and Lu L., Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Reply, Arthritis Rheum. 2013, 65(1): 285-7.

Deng J., Liu Y., Yang M., Wang S., Zhang M., Wang X., Ko K.H., Hua Z., Sun L., Cao X. and Lu L., Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response, Arthritis Rheum. 2012, 64(11): 3564-73.

Researcher : LAM YM

List of Research Outputs

LAM Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in normal mouse hematopoietic stem cells and leukemic cells, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

Researcher : LAU YT

List of Research Outputs

LAU Y.T., Ng I.O.L. and Lee K.W., Cancer Associated Fibroblasts and Hepatocellular Carcinoma, Journal of Liver: Disease & Transplantation . 2012, 1.

Researcher : Lam AKY

List of Research Outputs

Chan D., Tsoi M.Y.T., Liu C.D., Chan S.H., Law S.Y.K., Chan K.W., Chan Y.P., Gopalan V., Lam A.K.Y. and Tang J.C.O., Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma, World Journal of Gastroenterology. 2013, 19(18): 2772-2780.

Cheung L.C.M., Lai K.Y., Lam A.K.Y., Tang J.C.O., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Tong D.K.H. and Law S.Y.K., Gene expression profiling identified high-mobility group AT-hook (HMGA2) as being frequently upregulated in esophageal squamous cell carcinoma, British Journal of Medicine & Medical Research. 2013, 3(2): 407-419.

Researcher : Lam CW

Project Title:	Whole genome scan of genetic susceptibility for hepatitis B carries
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006

Project Title:	Therapeutic antibodies against basal cell carcinomas of the skin
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2009

Project Title:	Molecular basis of autism spectrum disorders in Chinese
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010
Completion Date:	09/2012

Project Title:	Clinical Biomonitoring of Environmental Chemicals
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	The first prospective second generation newborn screening in Hong Kong
Investigator(s):	Lam CW, Chan AYW, Mak CM
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Identifying the disease gene for a new locus of congenital myasthenic syndrome
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

List of Research Outputs

Lam C.W. and Mak C.M., Allele dropout caused by a non-primer-site SNV affecting PCR amplification--a call for next-generation primer design algorithm , In: Lam CW, Mak CM, Clin Chim Acta . 2013, 421:208-12.

Lam C.W., Omics-based medicine in Dermatology, 14th Beijing/Hong Kong Medical Exchange – From Medical to Cosmetic Dermatology (3-4 November 2012) Hong Kong, Hong Kong Medical Association and the Chinese Medical Association. 2012.

Mak C.M., Lam C.W., Chim S., Siu T.S., Ng K.F. and Tam S., Biochemical and molecular diagnosis of tyrosinemia type I with two novel FAH mutations in a Hong Kong chinese patient: recommendation for expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Chim S, Siu TS, Ng KF, Tam S, Clin Biochem. 2013, 46(1-2):155-9.

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Mak C.M., Lam C.W., Law C.Y., Siu C.W.K., Kwong L.L., Chan K.L., Chan W.T., Chow K.M., Lee K.W., Chan W.P. and Chan A.Y.W., Parental attitudes on expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Law CY, Siu WK, Kwong LL, Chan KL, Chan WT, Chow KM, Lee KW, Chan WP, Chan AY, Public Health. 2012, 126(11):954-9.

Qian M., Wu D., Wang E., Marincola F.M., Wang W., Rhodes W., Liebman M., Bai C., Lam C.W., Marko-Varga G., Fehniger T.E., Andersson R. and Wang X., Development and promotion in translational medicine: perspectives from 2012 sino-american symposium on clinical and translational medicine , In: Qian M, Wu D, Wang E, Marincola FM, Wang W, Rhodes W, Liebman M, Bai C, Lam CW, Marko-Varga G, Fehniger TE, Andersson R, Wang X, Clin Transl Med. 2012, 1(1):25.

Siu C.W.K., Mak C.M., Siu S.L.Y., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular Diagnosis for a Fatal Case of Very Long-chain Acyl-CoA Dehydrogenase Deficiency in Hong Kong Chinese With a Novel Mutation: A Preventable Death by Newborn Screening , In: Wai-Kwan Siu, Chloe Miu Mak, Sylvia Luen-Yee Siu, Tak-Shing Siu, Chun-Yin Pang, Ching-Wan Lam, Ngan-Shan Kwong, Albert Yan-Wo Chan, Diagnostic Molecular Pathology. 2012.

Siu C.W.K., Mak C.M., Siu S.L., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular diagnosis for a fatal case of very long-chain acyl-CoA dehydrogenase deficiency in Hong Kong Chinese with a novel mutation: a preventable death by newborn screening, In: Siu WK, Mak CM, Siu SL, Siu TS, Pang CY, Lam CW, Kwong NS, Chan AY, Diagn Mol Pathol. 2012, 21(3):184-7.

To K.K., Fung A.M., Teng J.L., Curreem S.O., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K. and Woo P.C., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis, and metabolic footprinting, In: To KK, Fung AM, Teng JL, Curreem SO, Lee KC, Yuen KY, Lam CW, Lau SK, Woo PC, J Clin Microbiol . 2013, 51(1):334-8.

To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.

Tsang J.P., Poon W.L., Luk H.M., Fung C.W., Ching D.C.K., Mak C.M., Lam C.W., Siu T.S., Tam S. and Wong V.C., Arginase deficiency with new phenotype and a novel mutation: contemporary summary, In: Tsang JP, Poon WL, Luk HM, Fung CW, Ching CK, Mak CM, Lam CW, Siu TS, Tam S, Wong VC, Pediatr Neurol. 2012, 47(4):263-9.

Tsang J.P.K., Poon W.L., Luk H.M., Fung C.W., Ching C.K., Mak C.M., Lam C.W., Siu T.S., Tam S. and Wong V.C.N., Arginase deficiency with new phenotype and a novel mutation: Contemporary Summary, Pediatric Neurology. 2012, 47(4): 263-269.

Tse H., Chan E., Lam C.W., Leung K.F., Chow P., Lee K.C., Sze K.H., Cheung S.K., Tse M.K., Ho P.L., Leung S.P., Lau S.K., Woo P.C. and Yuen K.Y., Production of 2-aminophenoxazin-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assays, In: Tse H, Chan E, Lam CW, Leung KF, Chow P, Lee KC, Sze KH, Cheung SK, Tse MK, Ho PL, Leung SP, Lau SK, Woo PC, Yuen KY, J Clin Microbiol. 2012, 50(11):3780-2.

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.

Wong S., Sin D.W., Kaarls R., Sargent M., Chu X., Chan T.Y., Lam C.W. and Seta K., International symposium on “Food and Health: from Measurement Science to Quality and Safety” , In: Siu-kay Wong, Della Wai-mei Sin, Robert Kaarls, Mike Sargent, Xiao-gang Chu, Thomas Yan-keung Chan, Chingwan Lam & Katsuo Seta, Accreditation and Quality Assurance Journal for Quality, Comparability and Reliability in Chemical Measurement. 2012.

Wong Y.M.M., Tang H.W., Man S.H., Lam C.W., Che C.M. and Ng K.M., Electrospray ionization on porous spraying tips for direct sample analysis by mass spectrometry: enhanced detection sensitivity and selectivity using hydrophobic/hydrophilic materials as spraying tips, Rapid Communications in Mass Spectrometry. 2013, 27: 713-721.

Woo P.C., Lam C.W., Tam E.W., Leung C.K., Wong S.S., Lau S.K. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei, In: Woo PC, Lam CW, Tam EW, Leung CK, Wong SS, Lau SK, Yuen KY, PLoS Negl Trop Dis. 2012, 6(10):e1871.

Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.

Yeung C.W., Yau M.M., Ma C.K., Siu T.S., Tam S. and Lam C.W., Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria, In: Yeung CW, Yau MM, Ma CK, Siu TS, Tam S, Lam CW, Hong Kong Med J . 2013, 19(3):272-5.

Researcher : Law CY

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Mak C.M., Lam C.W., Law C.Y., Siu C.W.K., Kwong L.L., Chan K.L., Chan W.T., Chow K.M., Lee K.W., Chan W.P. and Chan A.Y.W., Parental attitudes on expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Law CY, Siu WK, Kwong LL, Chan KL, Chan WT, Chow KM, Lee KW, Chan WP, Chan AY, Public Health. 2012, 126(11):954-9.

Researcher : Lee HHC

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Researcher : Lee KC

List of Research Outputs

To K.K., Fung A.M., Teng J.L., Curreem S.O., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K. and Woo P.C., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis, and metabolic footprinting, In: To KK, Fung AM, Teng JL, Curreem SO, Lee KC, Yuen KY, Lam CW, Lau SK, Woo PC, J Clin Microbiol . 2013, 51(1):334-8.

To K.K.W., Fung A.M.Y., Teng L.L., Curreem S.O.T., Lee K.C., Yuen K.Y., Lam C.W., Lau S.K.P. and Woo P.C.Y., Characterization of a Tsukamurella pseudo-outbreak by phenotypic tests, 16S rRNA sequencing, pulsed-field gel electrophoresis and metabolic footprinting, Journal of Clinical Microbiology. 2012, 51: 334-338.

Tse H., Chan E., Lam C.W., Leung K.F., Chow P., Lee K.C., Sze K.H., Cheung S.K., Tse M.K., Ho P.L., Leung S.P., Lau S.K., Woo P.C. and Yuen K.Y., Production of 2-aminophenoxazin-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assays, In: Tse H, Chan E, Lam CW, Leung KF, Chow P, Lee KC, Sze KH, Cheung SK, Tse MK, Ho PL, Leung SP, Lau SK, Woo PC, Yuen KY, J Clin Microbiol. 2012, 50(11):3780-2.

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.

Researcher : Lee KW

Project Title:	Clinical relevance and functional characterization of NEDD9 in hepatocellular carcinoma
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011
Completion Date:	03/2013

Project Title:	The significance of Nucleophosmin (NPM) phosphorylation in the progression of hepatocellular carcinoma
Investigator(s):	Lee KW, Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Clinical relevance and functional characterization of CD47 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012

Project Title:	Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD47
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2012

Project Title:	Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD47
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2012

Project Title:	The role of Hepatitis B virus in regulation of liver cancer stem cells properties
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

LAU Y.T., Ng I.O.L. and Lee K.W., Cancer Associated Fibroblasts and Hepatocellular Carcinoma, Journal of Liver: Disease & Transplantation . 2012, 1.

Researcher : Lee MF

List of Research Outputs

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Sze M.F., Chu K.Y., Lee M.F. and Ng I.O.L., C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma, Hepatology. 2012.

Researcher : Leung KF

List of Research Outputs

Tse H., Chan E., Lam C.W., Leung K.F., Chow P., Lee K.C., Sze K.H., Cheung S.K., Tse M.K., Ho P.L., Leung S.P., Lau S.K., Woo P.C. and Yuen K.Y., Production of 2-aminophenoxazin-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assays, In: Tse H, Chan E, Lam CW, Leung KF, Chow P, Lee KC, Sze KH, Cheung SK, Tse MK, Ho PL, Leung SP, Lau SK, Woo PC, Yuen KY, J Clin Microbiol. 2012, 50(11):3780-2.

Tse H., Chan E., Lam C.W., Leung K.F., Chow M.Y.P., Lee K.C., Sze K.H., Cheung S.K.K., Tse M.K., Ho P.L., Leung A.S.P., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Production of 2-aminophenoxazine-3-one by Staphylococcus aureus causes false-positive results in β-galactosidase assay, Journal of Clinical Microbiology. 2012, 50: 3780-3782.

Woo P.C.Y., Lam C.W., Tam W.T., Leung K.F., Wong S.S.Y., Lau S.K.P. and Yuen K.Y., First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei., PLoS Neglected Tropical Diseases . 2012, 6: e1871.

Researcher : Leung RYY

List of Research Outputs

Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.

Sim P.Y.J., Hwang Y.Y., Leung R.Y.Y., So J.C.C. and Kwong Y.L., Histiocytic sarcoma simulating immune thrombocytopenic purpura, Ann Hematol. 2013, 92(4): 555-6.

Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Genomics, genetics and clinico-pathological study of gastrointestinal cancers
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	07/2007

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

Project Title:	Genomics study for new mechanism of tumour suppressor gene silencing by transcriptional interference in colorectal cancer
Investigator(s):	Leung SY, Chan TL, Lok S, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

List of Research Outputs

Leung S.Y., "Genomics Study of Gastric Cancer" and co-chairing the session entitled “Cancer: Scientific Meeting of the Centre for Cancer Research”, Frontiers in Biomedical Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012.

Leung S.Y., Genomics Study of Gastric Cancer, The 2012 World Summit Forum of Intestinal disease, Beijing, China. 2012.

Leung S.Y., Genomics Study of Gastric Cancer, The Ninth Asia Pacific Multidisciplinary Meeting for Cancer Research and the Annual Scientific Meeting for Cancer Research entitled “Genomic Landscape of Cancer” organized by The Chinese University of Hong Kong. 2013.

Leung S.Y., Journal Editorial Board Membership, Journal of Clinical Pathology. 2013.

Leung S.Y., 染色質重塑基因ARID1A 突變與胃癌個體化診療, The 8th National Gastric Cancer Academic Conference and the 1st Sunlight Great Wall Cancer Academic Conference organized by Gastric Cancer Association, Beijing, China. 2013.

Researcher : Liu J

Project Title:	Identification and characterization of tumor-initiating cells in non-small cell lung carcinoma
Investigator(s):	Liu J, Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2013

List of Research Outputs

Wong M.P., Liu J., XIAO Z. and Tin P.C., The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through Hedgehog and Notch pathways in lung cancer, In: Wong MP, Liu J, Xiao Z, Tin PC, AACR Annual Meeting 2013 (April 6-10, 2013) Washington, DC. 2013.

Researcher : Lo CLR

Project Title:	Study of the role of Dickkopf-1 (DKK1) in liver cancer
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010
Completion Date:	12/2012

Project Title:	Study of testis-specific protein Y-encoded (TSPY) in hepatocellular carcinoma
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER; Testis-specific protein Y-encoded (TSPY) is overexpressed in hepatocellular carcinoma and may play a role in male predominance
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Project Title:	Identification of downstream targets of PIM1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Cheung T.T., Chok K.S.H., Lo C.L.R., Sharr W.W., Chan S.C., Poon R.T.P., Fan S.T. and Lo C.M., High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation, Hepatobiliary & Pancreatic Diseases International. 2012, 11(5): 542-544.

Cheung T.T., Fan S.T., Chan S.C., Chok K.S.H., Chu S.K.F., Jenkins C.R., Lo C.L.R., Fung J.Y.Y., Chan A.C.Y., Sharr W.W., Tsang S.H.Y., Dai W.C., Poon R.T.P. and Lo C.M., High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients, World Journal of Gastroenterology. 2013, 19(20): 3083-3089.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A.S.I.F., Wong D.K.H., Cho C.H.I. .H.I.N., Lai C.L. and Yuen R.M.F., Characterization of Interleukin-1β in Helicobacter pylori-induced Gastric Inflammation and DNA Methylation in IL-1 Receptor Type 1 Knockout (IL-1R1-/-) Mice , The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, February 21-25, 2013 at the Hyatt Regency Maui in Maui, HI.. 2013.

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.

Lo C.L.R., Cheung T.T. and Poon R.T.P., An Unusual Cause of Epigastric Pain, Gastroenterology. 2013.

Lo C.L.R. and Ng I.O.L., Hepatic progenitor cells - their role and functional significance in the new classification of primary liver cancers, Liver Cancer (in press). 2013.

Lo C.L.R., Chan S.C., Chan K.L., Chiang A.K.S., Lo C.M. and Ng I.O.L., Post-transplant lymphoproliferative disorders in liver transplant recipients: a clinicopathological study, Journal of Clinical Pathology. 2013, Epub on 2013-02-19: 392-8.

Lo C.L.R., Ng I.O.L., Kido T. and Lau C.Y.F., Testis-specific protein Y-encoded (TSPY) is overexpressed in hepatocellular carcinoma and may play a role in male predominance, APASL 2013.

Nabil S., Lo C.L.R. and Choi W.W.S., Simultaneous radicular cyst and mucoepidermoid carcinoma in the maxilla: a diagnostic nightmare , BMJ case reports. 2013.

Researcher : Loong F

List of Research Outputs

Gill H., Liu S., Ip A., Loong F., Lee E.Y.P., Leung R.Y.Y., Lau W.C.S., Ip W.K., Tam S. and Kwong Y.L., Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. , American Journal of Hematology. 2013.

Tse E.W.C., Gill H., Loong F., Kim S.J., NG S.B., Tang T., Ko Y.H., Chng W.Y., Lim S.T., Kim W.S. and Kwong Y.L., Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group, American Journal of Hematology. 2012, 87(7): 663-8.

Wong K.Y.M., Ho J.C.M., Loong F., Lam C.L.D., Wong W.M., Tam T.C., Han L. and Ip M.S.M., Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: the first experience in Hong Kong., Hong Kong Medical Journal. 2013, 19(1): 20 - 6.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Role of leptin in regulating B cell maturation and function
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009

Project Title:	The role of IL-17 in modulating B cell functions duringin anti-viral immunity against H5N1 influenza infection in mice
Investigator(s):	Lu L, Zheng B
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Roles of leptin in the regulation of T cell maturation and function
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	12/2012

Project Title:	Roles of B cells in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2012

Project Title:	Roles of leptin in regulating T cell function and autoimmune pathogenesis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Characterization of regulatory B cell and its functional implication in autoimmune diabetes
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Chan V.S.F., Tsang H.L., Tam C.Y., Lu L. and Lau W.C.S., B-cell-targeted therapies in systemic lupus erythematosus., Cellular & Molecular Immunology. 2013, 10(2): 133-42.

Deng J., Yang M., Liu Y., Wang X., Ko K.H. and Lu L., Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Reply, Arthritis Rheum. 2013, 65(1): 285-7.

Deng J., Liu Y., Yang M., Wang S., Zhang M., Wang X., Ko K.H., Hua Z., Sun L., Cao X. and Lu L., Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response, Arthritis Rheum. 2012, 64(11): 3564-73.

Feng G., Jiang Q., Xia M., Lu Y., Qiu W., Zhao D., Lu L., Peng G. and Wang Y., Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection, PLoS One. 2013, 8(4): e61135.

Kaiwen W., Zhaoliang S., Yinxia Z., Siamak S.S., Zhijun J., Yuan X., Heng Y., Dong Z., Yanfang L., Pei S., Shengjun W., Qixiang S., Xinxiang H., Lu L. and Huaxi X., Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA), Rheumatol Int. 2012, 32(8): 2331-8.

Li W., Zhou M., Ren H., Hu H.M., Lu L., Cao M. and Wang L.X., Tumor-derived autophagosomes (DRibbles) induce B cell activation in a TLR2-MyD88 dependent manner, PLoS One. 2013, 8(1): e53564.

Lu L., Croucher Senior Research Fellowship Award 2012/2013, Hong Kong Croucher Foundation . 2012.

Lu L., Frontiers in B-cell immunology, Cell Mol Immunol. 2013, 10(2): 95-6.

Qian L., Qian C., Chen Y., Bai Y., Bao Y., Lu L. and Cao X., Regulatory dendritic cells program B cells to differentiate into CD19hiFcgammaIIbhi regulatory B cells through IFN-beta and CD40L, Blood. 2012, 120(3): 581-91.

Sun J., Li R., Guo J., Jia Y., Sun X., Liu Y., Li Y., Huang F., Lu L. and Li Z., Superior molecularly altered influenza virus hemagglutinin peptide 308-317 inhibits collagen-induced arthritis by inducing CD4+ Treg cell expansion, Arthritis Rheum. 2012, 64(7): 2158-68.

Tang Y., Xie H., Chen J., Geng L., Chen H., Li X., Hou Y., Lu L., Shi S., Zeng X. and Sun L., Activated NF-kappaB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling, Stem Cells Dev. 2013, 22(4): 668-78.

Tang Y., Ma X., Zhang H., Gu Z., Hou Y., Gilkeson G.S., Lu L., Zeng X. and Sun L., Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus, Clin Dev Immunol. 2012, 2012: 826182.

Tian J., Ma J., Ma K., Ma B., Tang X., Baidoo S.E., Tong J., Yan J., Lu L., Xu H. and Wang S., Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma, PLoS One. 2012, 7(10): e46936.

Tian J., Ma J., Ma K., Guo H., Baidoo S.E., Zhang Y., Yan J., Lu L., Xu H. and Wang S., beta-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells, Eur J Immunol. 2013, 43(5): 1220-30.

Yang M., Rui K., Wang S. and Lu L., Regulatory B cells in autoimmune diseases, Cell Mol Immunol. 2013, 10(2): 122-32.

Researcher : Lu P

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Researcher : MAK HYQ

List of Research Outputs

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, has suppressive role in mitotic checkpoint signaling in hepatocellular carcinoma, 19th Hong Kong International Cancer Congresss . 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, suppresses mitotic checkpoint signaling in hepatocellular carcinoma, American Association for Cancer Research Annual Meeting 2013.

Researcher : Ma ESK

List of Research Outputs

Lo V.M., Ma E.S.K., Chau E.M. and So J.C.C., A spuriously 'normal' haemoglobin A1c result, Ann Clin Biochem. 2012, 49(Pt 4): 408-11.

Researcher : Ma SKY

Project Title:	Transcriptome sequencing (RNA-Seq) identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal carcinoma (ESCC)
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	07/2012

Project Title:	Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012

Project Title:	Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):	Ma SKY, Wong AST
Department:	Pathology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

Project Title:	Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):	Ma SKY, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Epigenetic modulation of CD133+ liver cancer stem cells by chromatin-modifying enzymes
Investigator(s):	Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	International Liver Transplantation Society - 19th Annual International Congress; Biology and clinical implications of CD133+ liver cancer stem cells
Investigator(s):	Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Researcher : Ma W

List of Research Outputs

Ma W., Wong C.C.L., Tung K.K., Wong C.M. and Ng I.O.L., RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway, Hepatology. 2012.

Researcher : Mak CM

List of Research Outputs

Lam C.W. and Mak C.M., Allele dropout caused by a non-primer-site SNV affecting PCR amplification--a call for next-generation primer design algorithm , In: Lam CW, Mak CM, Clin Chim Acta . 2013, 421:208-12.

Mak C.M., Lam C.W., Chim S., Siu T.S., Ng K.F. and Tam S., Biochemical and molecular diagnosis of tyrosinemia type I with two novel FAH mutations in a Hong Kong chinese patient: recommendation for expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Chim S, Siu TS, Ng KF, Tam S, Clin Biochem. 2013, 46(1-2):155-9.

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Mak C.M., Lam C.W., Law C.Y., Siu C.W.K., Kwong L.L., Chan K.L., Chan W.T., Chow K.M., Lee K.W., Chan W.P. and Chan A.Y.W., Parental attitudes on expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Law CY, Siu WK, Kwong LL, Chan KL, Chan WT, Chow KM, Lee KW, Chan WP, Chan AY, Public Health. 2012, 126(11):954-9.

Siu C.W.K., Mak C.M., Siu S.L.Y., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular Diagnosis for a Fatal Case of Very Long-chain Acyl-CoA Dehydrogenase Deficiency in Hong Kong Chinese With a Novel Mutation: A Preventable Death by Newborn Screening , In: Wai-Kwan Siu, Chloe Miu Mak, Sylvia Luen-Yee Siu, Tak-Shing Siu, Chun-Yin Pang, Ching-Wan Lam, Ngan-Shan Kwong, Albert Yan-Wo Chan, Diagnostic Molecular Pathology. 2012.

Siu C.W.K., Mak C.M., Siu S.L., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular diagnosis for a fatal case of very long-chain acyl-CoA dehydrogenase deficiency in Hong Kong Chinese with a novel mutation: a preventable death by newborn screening, In: Siu WK, Mak CM, Siu SL, Siu TS, Pang CY, Lam CW, Kwong NS, Chan AY, Diagn Mol Pathol. 2012, 21(3):184-7.

Tsang J.P., Poon W.L., Luk H.M., Fung C.W., Ching D.C.K., Mak C.M., Lam C.W., Siu T.S., Tam S. and Wong V.C., Arginase deficiency with new phenotype and a novel mutation: contemporary summary, In: Tsang JP, Poon WL, Luk HM, Fung CW, Ching CK, Mak CM, Lam CW, Siu TS, Tam S, Wong VC, Pediatr Neurol. 2012, 47(4):263-9.

Researcher : Mak CY

List of Research Outputs

Mak C.Y., Lee L., Siu K.Y., Wong G.W., Lu X., Ngan H.Y.S., Wong E.S. and Cheung A.N.Y., Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation , Carcinogenesis. 2013, June 2013.

Mak C.Y., Siu K.Y., Wong G.W., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., Dysregulated stemness-related genes in gynecological malignancies., Histology and histopathology. 2012, 27: 1121-1130.

Researcher : Man PS

List of Research Outputs

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

Researcher : NG TT

List of Research Outputs

NG T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of the Nucleus Pulposus Cells for Degenerative Disc Disorder, Gordon Research Conference on Cartilage Biology & Pathology. Les Diablerets, Switzerland, 2013.

Ng T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of Nucleus Pulposus Cells for Degenerative Disc Disorder, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	Molecular Pathology of Liver Cancer - a Multidisciplinary Study
Investigator(s):	Ng IOL, Cheung ST, Ching YP, Guan X, Jin D, Lee KW, Poon RTP, Wong CM
Department:	Pathology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2010

Project Title:	Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):	Ng IOL, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	RhoE dysregulation in liver cancer and metastasis
Investigator(s):	Ng IOL, Wong CM, Chan LK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	11/2012

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL, Tung KK
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2011

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	10/2011

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2011

Project Title:	Significance of RhoE dysregulation in liver cancer and metastasis
Investigator(s):	Ng IOL, Chan LK, Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	Dissection of DLC1/Rho/ROCK2 signaling pathway in liver cancer
Investigator(s):	Ng IOL, Chan LK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Dissecting the gender disparity of hepatocellular carcinoma: Roles of HBV X protein and androgen receptor
Investigator(s):	Ng IOL, Chiu YT
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013

Project Title:	Role of hypoxia-inducible miR-210 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Laennec Liver Pathology Society Annual Meeting; C-terminal truncated HBx is associated with cell invasiveness via c-Jun/MMP10 activation in HCC
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

Au L.K.S., Ng I.O.L. and Wong C.M., Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins, Front Med. 2013, 7: 231-41.

Au L.K.S., Ng I.O.L. and Wong C.M., Regulation of EZH2 and its targeted microRNAs, In: Sarkar FH, Epigenetics and Cancer. Springer, 2013, 33-62.

Chew V., Tow C., Huang C., Bard-Chapeau E., Copeland N.G., Jenkins N.A., Weber A., Lim K.H., Toh H.C., Heikenwalder M., Ng I.O.L., Nardin A. and Abastado J.P., Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients, J Natl Cancer Inst. 2012, 23: 1796-807.

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Fung J.Y.Y., Yuen R.M.F., Lai C.L. and Ng I.O.L., Do statins reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis B?, Hepatobiliary Surgery and Nutrition. 2013, 2(1): 34-6.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Cheung C.K.Y., Chan A.C.Y., Sharr W.W., Cheung T.T., Wong C.L.T., Seto W.K.W., Lai C.L., Ng I.O.L., Yuen R.M.F. and Lo C.M., Risk of recurrent hepatocellular carcinoma in chronic hepatitis B patients after liver transplantation (Poster Presentation), International Liver Transplantation Society 19th Annual International Congress, Sydney, Australia, 12-15 June 2013.

Ho D.W.H., Wong C.M., Sham P.C. and Ng I.O.L., Pathway analysis of genome-wide association data on hepatocellular carcinoma in southern Chinese patients with chronic hepatitis B virus infection., Joint Conference of HGM 2013 and 21st International Congress of Genetics.. 2013.

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

LAU Y.T., Ng I.O.L. and Lee K.W., Cancer Associated Fibroblasts and Hepatocellular Carcinoma, Journal of Liver: Disease & Transplantation . 2012, 1.

Lo C.L.R. and Ng I.O.L., Hepatic progenitor cells - their role and functional significance in the new classification of primary liver cancers, Liver Cancer (in press). 2013.

Lo C.L.R., Chan S.C., Chan K.L., Chiang A.K.S., Lo C.M. and Ng I.O.L., Post-transplant lymphoproliferative disorders in liver transplant recipients: a clinicopathological study, Journal of Clinical Pathology. 2013, Epub on 2013-02-19: 392-8.

Lo C.L.R., Ng I.O.L., Kido T. and Lau C.Y.F., Testis-specific protein Y-encoded (TSPY) is overexpressed in hepatocellular carcinoma and may play a role in male predominance, APASL 2013.

Ma W., Wong C.C.L., Tung K.K., Wong C.M. and Ng I.O.L., RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway, Hepatology. 2012.

Mak W.Y.G., Lai W.L., Zhou Y., Li M., Ng I.O.L. and Ching Y.P., CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells, PLOS ONE. 2012, 7(7), pp: e42210.

Ng I.O.L., Associate Editor, Liver International (Official journal of International Association for the Study of the Liver) . 2012.

Ng I.O.L., C-terminal truncated HBx is associated with cell invasiveness via c-Jun/MMP10 activation in HCC, Annual Meeting, the Laennec Liver Pathology Society Annual Meeting, Singapore. 2013.

Ng I.O.L., Croucher Senior Medical Research Fellowship 2013-2014, Croucher Foundation. 2012.

Ng I.O.L., Faculty Outstanding Research Output Award, The University of Hong Kong. 2012.

Ng I.O.L., HCC research: Molecular drivers and signalling pathway, 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL), Singapore. 2013.

Ng I.O.L., Journal of Gastroenterology and Hepatology. 2012.

Ng I.O.L., Liver cancer stem cells in hepatocellular carcinoma, The 7th Princess Chulabhorn International Science Congress -Cancer: from Basic Research to Cure, Bangkok, Thailand. 2012.

Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, 19th Annual Meeting, Korean Association for the Study of the Liver, Seoul, Korea. 2013.

Ng I.O.L., Pathology and pathogenesis of HCC, The 3rd Asia-Pacific Primary Liver Cancer Expert Meeting - A Bridge to a Consensus on HCC Management, Shanghai, China. 2012.

Sze M.F., Chu K.Y., Lee M.F. and Ng I.O.L., C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma, Hepatology. 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, has suppressive role in mitotic checkpoint signaling in hepatocellular carcinoma, 19th Hong Kong International Cancer Congresss . 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, suppresses mitotic checkpoint signaling in hepatocellular carcinoma, American Association for Cancer Research Annual Meeting 2013.

Tung K.K. and Ng I.O.L., Significance of serum DKK1 as a diagnostic biomarker in hepatocellular carcinoma, Future Oncol. 2012, 8: 1525-8.

Wong C.M., Kai K.L.A., Tsang F.H. and Ng I.O.L., Regulation of hepatocarcinogenesis by microRNAs., Front Biosci (Elite Ed). 2013, 5: 49-60.

Yang W., Tang H., Zhang Y., Tang X., ZHANG J., Sun L., Yang J., Cui Y., Zhang L., Hirankarn N., Cheng H., Pan H.F., Gao J., Lee T.L., Sheng Y., Lau W.C.S., Li Y., Chan T.M., Yin X., Ying D., Lu Q., Leung A.M.H., Zuo X., Chen X., Tong K.L., Zhou F., Diao Q., Tse N.K.C., Xie H., Mok C.C., Hao F., Wong S.N., Shi B., Lee K.W., Hui Y., Ho M.H.K., Liang B., Lee P.P.W., Cui H., Guo Q., Chung B.H.Y., Pu X., Liu Q., Zhang X., Zhang C., Chong C.Y., Fang H., Wong R.W.S., Sun Y., Mok T.M.Y., Li X.P., Avihingsanon Y., Zhi Z., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Gao F., Shotelersuk V., Kang X., Ying S.K.Y., Zhang L., Wong W.H.S., Zhu D., Fung S.K.S., Zeng F., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Shen N., Tam P.K.H., Sham P.C., Ye D.Q., Yang S., Zhang X. and Lau Y.L., Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians, The American Journal of Human Genetics. 2013, 92: 41-51.

Researcher : Ng RK

Project Title:	The functional roles of histone H3K9 demethylase Jmjd2 family in determination of trophoblast lineages
Investigator(s):	Ng RK, Lee CYL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Role of RUNX1 in the establishment of leukemic stem cells in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Function of PRMT1 in the establishment of leukemia stem cell
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

LAM Y.M., Chan L.C. and Ng R.K., Role of Bmi-1 in normal mouse hematopoietic stem cells and leukemic cells, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

NG T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of the Nucleus Pulposus Cells for Degenerative Disc Disorder, Gordon Research Conference on Cartilage Biology & Pathology. Les Diablerets, Switzerland, 2013.

Ng T.T., Au Y.K., Cheah K.S.E., Sham M.H. and Ng R.K., Regeneration of Nucleus Pulposus Cells for Degenerative Disc Disorder, Hong Kong Society for Developmental Biology Symposium : From Embryology to Disease Mechanism, November 26-27, 2012.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, Hong Kong, December 12-13, 2012.

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2012.

ZHANG J., Ng R.K. and Chan L.C., Functions of JARID1B in the Regulation of Hematopoiesis and Leukemogenesis, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

Researcher : Ng TT

List of Research Outputs

Researcher : Ngan HYS

Project Title:	High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer
Investigator(s):	Ngan HYS, Wong RLC
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1994

Project Title:	Functional role of DNp73-C35 interaction in chemo-resistance of ovarian cancer.
Investigator(s):	Ngan HYS, Leung THY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011

Project Title:	Functional characterization and clinical significance of DNp73-C35 in ovarian cancer
Investigator(s):	Ngan HYS, Chan KKL, Cheung ANY, Leung THY
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Characterization of tumor initiating cell population expressing CD55 in cervical cancer.
Investigator(s):	Ngan HYS, Leung THY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012

Project Title:	Clinical significance and application of HPV-related microRNAs in cervical pre-maglinant lesions and cancer
Investigator(s):	Ngan HYS, Liu S, Ng EKO, Cheung ANY, Chan KKL, Kwong A
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Roles of CD55(+) population and HPV viral proteins on tumor progression in cervical cancer cells
Investigator(s):	Ngan HYS, Leung THY, Cheung ANY, Chan KKL
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2013

List of Research Outputs

Mak C.Y., Siu K.Y., Wong G.W., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., Dysregulated stemness-related genes in gynecological malignancies., Histology and histopathology. 2012, 27: 1121-1130.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Investigations into influenza receptor binding and novel therapies in an ex-vivo setting
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	10/2009

Project Title:	Influenza and sialic acid linked glycan interactions using virus like pseudoparticles (VLP) and STD-NMR
Investigator(s):	Nicholls JM, Poon LLM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2009
Completion Date:	01/2013

Project Title:	Prevention and treatment of swine origin influenza virus (S-OIV) though the use of interferon - an in vivo and ex vivo study
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Sialoglyco2010 An update of inhibition of influenza infection by sialidase treatment
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2010

List of Research Outputs

Chan M.C.W., Chan W.Y., Leung C.Y.H., Fang X., Nicholls J.M., Lee J., Matthay M.A. and Peiris J.S.M., Effect of human mesenchymal stem cells on enhancing alveolar fluid clearance in human alveolar epithelium injured by influenza H5N1 virus infection, 6th Annual CEIRS Network Meeting . 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus pathogenesis in human respiratory epithelial cell , The Pulmonary Centre, Boston University School of Medicine. 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus tropism in human and swine respiratory tract, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, US . 2012.

Chan W.Y., Nicholls J.M. and Peiris J.S.M., Influenza virus tropism in human respiratory tract, 3rd Annual World Congress of Virus and Infection. 2012.

Chan W.Y., Leung C.Y.H., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses., PLoS One. 2012, 7(11): e51057.

Chan W.Y., Chan M.C.W., Agnihothram S., Chan L.Y., Kuok I.T., Fong J.H.M., Guan Y., Poon L.L.M., Baric R.S., Nicholls J.M. and Peiris J.S.M., Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures., Journal of Virology. 2013, 87(12): 6604-14.

Chan W.Y., Chan M.C.W., Nicholls J.M. and Peiris J.S.M., Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses, Virus Research. 2013, S0168-1702(13): 00078-6.

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.

Gong J., Liu H., Nicholls J.M. and Li X.C., Studies on the sialylation of galactoses with different C-5 modified sialyl donors, Carbohydrate Research. 2012, 361: 91-99.

Huang Z., Cheng Y., Chiu P.M., Cheung F.M.F., Nicholls J.M., Kwong D.L.W., Lee A.W.M., Zabarovsky E.R., Stanbridge E.J., Lung H.L. and Lung M.L., Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties, Oncogene. 2012, 31(32): 3709-3720.

LEUNG H.S., LI O.T., Chan W.Y., CHAN M.C., Nicholls J.M. and POON L.L., The virus entry of influenza A virus with a α2,6-linked sialic acid binding preference requires host fibronectin, In: Leung HS, Li OT, Chan RW, Chan MC, Nicholls JM, Poon LL, J Virol. 2012.

Leung S.Y.H., Li O.T.W., Chan W.Y., Chan M.C.W., Nicholls J.M. and Poon L.L.M., Entry of influenza A Virus with a alpha2,6-linked sialic acid binding preference requires host fibronectin, Journal of virology. 2012, 86(19): 10704-13.

Walther T.J., Karamanska R., Chan W.Y., Chan M.C.W., Jia N., Air G., Hopton C.L., Wong M.P., Dell A., Peiris J.S.M., Haslam S.M. and Nicholls J.M., Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection, PLoS Pathogen. 2013, 9(3): e1003223.

Researcher : Poon DWT

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Researcher : Shek TWH

List of Research Outputs

Cheung J.P., Ho K.W.Y., Lam Y.L. and Shek T.W.H., Unusual presentations of osteoarticular tuberculosis in two paediatric patients, BMJ Case Rep. 2012, 2012.

Gu J., Khong P.L., Wang S., Law W.L., Chan T., Shek T.W.H., Liu K.Y. and Zhang J., Combined use of 18F-FDG PET/CT DW-MRI and DCE-MRI in treatment response for preoperative chemoradiation therapy in locally invasive rectal cancers, Clinical Nuclear Medicine. 2013, 38(5): e226-229.

Leung R.C.Y., Lang B.H.H., Wong H.Y.H., Chiu J.W.Y., Wan K.Y., Shek T.W.H., Woo Y.C., Lo C.Y. and Yau T.C.C., Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy, Anti-Cancer Agents in Medicinal Chemistry. 2013, 13(3): 382-388.

Researcher : Siu CWK

List of Research Outputs

Mak C.M., Siu C.W.K., Law C.Y., Wong C.K., Lee H.K., Yeung S., Sham C.O., Tse K., Lee H.H.C., Chen S.P.L., Ching D.C.K., Au C.K., Poon D.W.T., Lam C.W., Kwong N.S. and Chan A.Y.W., Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients , Journal of Clinical Pathology. 2012.

Mak C.M., Lam C.W., Law C.Y., Siu C.W.K., Kwong L.L., Chan K.L., Chan W.T., Chow K.M., Lee K.W., Chan W.P. and Chan A.Y.W., Parental attitudes on expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Law CY, Siu WK, Kwong LL, Chan KL, Chan WT, Chow KM, Lee KW, Chan WP, Chan AY, Public Health. 2012, 126(11):954-9.

Siu C.W.K., Mak C.M., Siu S.L.Y., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular Diagnosis for a Fatal Case of Very Long-chain Acyl-CoA Dehydrogenase Deficiency in Hong Kong Chinese With a Novel Mutation: A Preventable Death by Newborn Screening , In: Wai-Kwan Siu, Chloe Miu Mak, Sylvia Luen-Yee Siu, Tak-Shing Siu, Chun-Yin Pang, Ching-Wan Lam, Ngan-Shan Kwong, Albert Yan-Wo Chan, Diagnostic Molecular Pathology. 2012.

Siu C.W.K., Mak C.M., Siu S.L., Siu T.S., Pang C.Y., Lam C.W., Kwong N.S. and Chan A.Y.W., Molecular diagnosis for a fatal case of very long-chain acyl-CoA dehydrogenase deficiency in Hong Kong Chinese with a novel mutation: a preventable death by newborn screening, In: Siu WK, Mak CM, Siu SL, Siu TS, Pang CY, Lam CW, Kwong NS, Chan AY, Diagn Mol Pathol. 2012, 21(3):184-7.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

List of Research Outputs

Mak C.Y., Lee L., Siu K.Y., Wong G.W., Lu X., Ngan H.Y.S., Wong E.S. and Cheung A.N.Y., Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation , Carcinogenesis. 2013, June 2013.

Mak C.Y., Siu K.Y., Wong G.W., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., Dysregulated stemness-related genes in gynecological malignancies., Histology and histopathology. 2012, 27: 1121-1130.

Researcher : So JCC

Project Title:	Genetic diagnosis of hereditary spherocytosis in Chinese - a prototype for studying hereditary haemolytic anaemias
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Establishment of a Molecular Strategy for Direct Genotypic Characterisation of Moderate and Severe Haemophilia A in Hong Kong
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Lo V.M., Ma E.S.K., Chau E.M. and So J.C.C., A spuriously 'normal' haemoglobin A1c result, Ann Clin Biochem. 2012, 49(Pt 4): 408-11.

Sim P.Y.J., Hwang Y.Y., Leung R.Y.Y., So J.C.C. and Kwong Y.L., Histiocytic sarcoma simulating immune thrombocytopenic purpura, Ann Hematol. 2013, 92(4): 555-6.

Singh G.H., Ip A.H., Leung R.Y.Y., So J.C.C., Pang A.W.K., Tse E.W.C., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis, Bone Marrow Transplant. 2012, 47(7): 952-6.

So J.C.C., Antenatal screening and prenatal diagnosis of thalassaemia, Faculty of Health Sciences, Macau University of Science and Technology, Macau . 2013.

So J.C.C., Characterisation of unusual cytogenetic abnormalities in a case of diffuse large B-cell lymphoma, Lymphoma Conference organized by University of California Los Angeles and Hong Kong Sanatorium and Hospital, Hong Kong. 2013.

So J.C.C., Yung K.H., Chu M.L. and Wan T.S.K., Diagnostic challenges in a case of B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, Int J Hematol. 2013, [In press].

So J.C.C., Diagnostic technologies of tomorrow, Commission training for medical laboratory technologists HAHO 2012, Hong Kong . 2012.

So J.C.C., Genetic basis and laboratory diagnosis of thalassaemia, Faculty of Health Sciences, Macau University of Science and Technology, Macau . 2013.

So J.C.C., Haematologist counts: From blood counting to haematological diagnosis, 1st Hong Kong Pathology Forum organized by Department of Pathology, The University of Hong Kong, Hong Kong. 2013.

So J.C.C., Choi W.L. and Kwong Y.L., Pure red cell aplasia associated with CD20+ myeloma: complete remission with rituximab, Ann Hematol. 2013.

So J.C.C., The genetic basis of haemophilia and other congenital bleeding disorders, The University of Hong Kong & Royal Free Hospital Coagulation Workshop 2012, Hong Kong . 2012.

So J.C.C., Where are we now in Hong Kong?, The University of Hong Kong & Royal Free Hospital Coagulation Workshop 2012, Hong Kong . 2012.

Surapolchai P., Ha S.Y., Chan G.C.F., Lukito J.B., Wan T.S.K., So J.C.C. and Chiang A.K.S., Central Diabetes Insipidus: An Unusual Complication in a Child With Juvenile Myelomonocytic Leukemia and Monosomy 7, Journal of Pediatric Hematology and Oncology. 2013, 35: e84-e87.

Researcher : Srivastava G

Project Title:	Identification of direct and indirect targets of the del 6q putative tumor suppressor PRDM1 gene in NK cells, and the role of the aberrant expression of these PRDM1 downstream target genes in the pathogenesis of NK-cell malignancies
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009

Project Title:	Inactivation of the transcriptional repressor PRDM1 and imbalance in the expression of PRDM1 ?and ?isoforms in NK-cell malignancies, and their roles in the pathogenesis
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009
Completion Date:	09/2012

Project Title:	Tumor suppressor role of PRKCBP1, a novel translocation partner of IGH gene, in the pathogenesis of gastric and other B-cell non-Hodgkin’s lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Molecular features and functional consequences of a novel recurrent t(14;20)(q32;q13.12)/IGHS?PRKCBP1 translocation in gastric and other B-cell non-Hodgkins lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	Epigenetic silencing of the lymphocyte homing receptor CD44 in reactive germinal center B cells (GCB) and its activation in GCB-derived lymphomas by aberrant promoter hypomethylation
Investigator(s):	Srivastava G, Choi WL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

Project Title:	The roles of FOXP1 and its N-terminally truncated isoforms in the pathogenesis of diffuse large B-cell lymphoma
Investigator(s):	Srivastava G, Choi WL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

List of Research Outputs

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung L.C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(5): 3009-3016.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(3): 1699-1706.

Li L., Ying J., Li H., Zhang Y., Shu X., Fan Y., Tan J., Cao Y., Tsao G.S.W., Srivastava G., Chan A.T. and Tao Q., The human acdherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas, Oncogene. 2012, Aug 23;31(34):: 3901-12.

Love C., Sun Z., Jima D., Li G., Zhang J., Miles R., Richards K.L., Dunphy C.H., Choi W.L., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Chadburn A., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Greenough A., Moffitt A.B., McKinney M., Banerjee A., Grubor V., Levy S., Dunson D.B. and Dave S.S., The genetic landscape of mutations in Burkitt lymphoma, Nat Genet. 2012, 44(12): 1321-5.

Love C.L., Jima D., Sun Z., Miles R.R., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Lugar P., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K., Evens A.M., Chadburn A., Gordon L.I., Czader M., Gill J., Hsi E.D., Zhang J., Grubor V., Levy S., Bunerjee A., Dunson D., Li G., Moffitt A., Greenough A., McKinney M.S. and Dave S.S., ID3 is a novel tumor suppressor gene in Burkitt lymphoma, The 54th American Society of Hematology Annual Meeting and Exposition. 2012.

Wang Z., Li L., Su X., Gao Z., Srivastava G., Murray P.G., Ambinder R. and Tao Q., Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas, J Transl Med. 2012, 10: 209.

Yuen H.F., Abramczyk O., Montgomery G., Chan K.K., Huang Y.H., Sasazuki T., Shirasawa S., Srivastava G., Chan K.W., Fennell D., Janne P., El-Tanani M. and Murray J.T., Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells, Biosci Rep. 2012, 32(4): 413-22.

Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W.L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D. and Dave S.S., Genetic heterogeneity of diffuse large B-cell lymphoma, Proc Natl Acad Sci U S A. 2013, 110(4): 1398-403.

Researcher : Sze MF

Project Title:	The functional characterizations of Proline Rich acidic protein 1 (PRAP1) in chromosomal segregation machinery via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Sze M.F., Chu K.Y., Lee M.F. and Ng I.O.L., C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma, Hepatology. 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, has suppressive role in mitotic checkpoint signaling in hepatocellular carcinoma, 19th Hong Kong International Cancer Congresss . 2012.

Sze M.F., Chu K.Y., MAK H.Y.Q. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1), a novel mitotic arrest deficient 1 (MAD1) interacting partner, suppresses mitotic checkpoint signaling in hepatocellular carcinoma, American Association for Cancer Research Annual Meeting 2013.

Researcher : Tam HKA

List of Research Outputs

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Researcher : Tam S

List of Research Outputs

Mak C.M., Lam C.W., Chim S., Siu T.S., Ng K.F. and Tam S., Biochemical and molecular diagnosis of tyrosinemia type I with two novel FAH mutations in a Hong Kong chinese patient: recommendation for expanded newborn screening in Hong Kong, In: Mak CM, Lam CW, Chim S, Siu TS, Ng KF, Tam S, Clin Biochem. 2013, 46(1-2):155-9.

Tsang J.P., Poon W.L., Luk H.M., Fung C.W., Ching D.C.K., Mak C.M., Lam C.W., Siu T.S., Tam S. and Wong V.C., Arginase deficiency with new phenotype and a novel mutation: contemporary summary, In: Tsang JP, Poon WL, Luk HM, Fung CW, Ching CK, Mak CM, Lam CW, Siu TS, Tam S, Wong VC, Pediatr Neurol. 2012, 47(4):263-9.

Yeung C.W., Yau M.M., Ma C.K., Siu T.S., Tam S. and Lam C.W., Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria, In: Yeung CW, Yau MM, Ma CK, Siu TS, Tam S, Lam CW, Hong Kong Med J . 2013, 19(3):272-5.

Yeung C.W., Mak C.M., Lam K.S.L. and Tam S., Hypoglycaemia due to autoimmune insulin syndrome in a 78-year-old Chinese man, Br J Biomed Sci. 2012, 69: 80-2.

Researcher : Tang JCO

List of Research Outputs

Chan D., Tsoi M.Y.T., Liu C.D., Chan S.H., Law S.Y.K., Chan K.W., Chan Y.P., Gopalan V., Lam A.K.Y. and Tang J.C.O., Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma, World Journal of Gastroenterology. 2013, 19(18): 2772-2780.

Cheung L.C.M., Lai K.Y., Lam A.K.Y., Tang J.C.O., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Tong D.K.H. and Law S.Y.K., Gene expression profiling identified high-mobility group AT-hook (HMGA2) as being frequently upregulated in esophageal squamous cell carcinoma, British Journal of Medicine & Medical Research. 2013, 3(2): 407-419.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung L.C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(5): 3009-3016.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(3): 1699-1706.

Researcher : Tang KH

List of Research Outputs

Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.

Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.

Researcher : Tang KH

List of Research Outputs

Researcher : Tin PC

List of Research Outputs

Wong M.P., Liu J., XIAO Z. and Tin P.C., The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through Hedgehog and Notch pathways in lung cancer, In: Wong MP, Liu J, Xiao Z, Tin PC, AACR Annual Meeting 2013 (April 6-10, 2013) Washington, DC. 2013.

Researcher : Tsang FH

List of Research Outputs

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Wong C.M., Kai K.L.A., Tsang F.H. and Ng I.O.L., Regulation of hepatocarcinogenesis by microRNAs., Front Biosci (Elite Ed). 2013, 5: 49-60.

Researcher : Tse EYT

Project Title:	Characterization of NIMA (never in mitosis gene a)-related kinase 2 (Nek2) in Hepatocellular Carcinoma (HCC)
Investigator(s):	Tse EYT, Ching YP
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Researcher : Tung KK

List of Research Outputs

Ma W., Wong C.C.L., Tung K.K., Wong C.M. and Ng I.O.L., RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway, Hepatology. 2012.

Tung K.K. and Ng I.O.L., Significance of serum DKK1 as a diagnostic biomarker in hepatocellular carcinoma, Future Oncol. 2012, 8: 1525-8.

Researcher : Walther TJ

List of Research Outputs

Walther T.J., Karamanska R., Chan W.Y., Chan M.C.W., Jia N., Air G., Hopton C.L., Wong M.P., Dell A., Peiris J.S.M., Haslam S.M. and Nicholls J.M., Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection, PLoS Pathogen. 2013, 9(3): e1003223.

Researcher : Wan TSK

List of Research Outputs

So J.C.C., Yung K.H., Chu M.L. and Wan T.S.K., Diagnostic challenges in a case of B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, Int J Hematol. 2013, [In press].

Surapolchai P., Ha S.Y., Chan G.C.F., Lukito J.B., Wan T.S.K., So J.C.C. and Chiang A.K.S., Central Diabetes Insipidus: An Unusual Complication in a Child With Juvenile Myelomonocytic Leukemia and Monosomy 7, Journal of Pediatric Hematology and Oncology. 2013, 35: e84-e87.

Researcher : Wang X

List of Research Outputs

Deng J., Yang M., Liu Y., Wang X., Ko K.H. and Lu L., Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Reply, Arthritis Rheum. 2013, 65(1): 285-7.

Deng J., Liu Y., Yang M., Wang S., Zhang M., Wang X., Ko K.H., Hua Z., Sun L., Cao X. and Lu L., Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response, Arthritis Rheum. 2012, 64(11): 3564-73.

Researcher : Wei L

List of Research Outputs

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Researcher : Wong CCL

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

Project Title:	Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	The use of anti-lysyl oxidase-like 2 (anti-LOLX2) monocolonal antibodies in the treatment of liver cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013

List of Research Outputs

Chaturvedi P., Gilkes D., Wong C.C.L., Kshitiz K., Luo W., Zhang H., Wei H., Takano N., Schito L., Levchenko K. and Semenza G.L., Hypoxia-inducible Factor-dependent Breast Cancer-mesenchymal Stem Cell Bidirectional Signaling Promotes Metastasis., Journal Of Clinical Investigation. 2012, 123: 189-205.

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Gilkes D.M., Chaturvedi P., Bajpai S., Wong C.C.L., Wei H., Pitcairn S., Hubbi M.E., Wirtz D. and Semenza G.L., Collagen Prolyl Hydroxylases Are Essential For Breast Cancer Metastasis, Molecular Cancer Research. 2013, 73: 3285-96.

Gilkes D.M., Bajpai S., Wong C.C.L., Chaturvedi P., Hubbi M.E., Wirtz D. and Semenza G.L., Procollagen Lysyl Hydroxylase 2 Is Essential For Hypoxia-induced Breast Cancer Metastasis, Cancer Research. 2013, 11: 456-66.

Hubbi M.E., Kshitiz K., Gilkes D.M., Rey S., Wong C.C.L., Kim D., Dang C.V., Levchenko A. and Semenza G.L., A Nontranscriptional Role For Hif-1α As A Direct Inhibitor Of Dna Replication, Science Signaling. 2013, 6: ra10.

Ma W., Wong C.C.L., Tung K.K., Wong C.M. and Ng I.O.L., RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway, Hepatology. 2012.

Schito L., Rey S., Tafani M., Zhang H., Wong C.C.L., Russo A., Russo M.A. and Semenza G.L., Hypoxia-inducible Factor 1-dependent Expression Of Platelet-derived Growth Factor B Promotes Lymphatic Metastasis Of Hypoxic Breast Cancer Cells., Proc Natl Acad Sci U S A.. 2012, 109: E2707-16.

Researcher : Wong CL

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

Project Title:	Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	The use of anti-lysyl oxidase-like 2 (anti-LOLX2) monocolonal antibodies in the treatment of liver cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013

List of Research Outputs

Researcher : Wong CM

Project Title:	Characterization of EZH2 mediated miRNA deregulation in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	Polycomb silencing and microRNA deregulation in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2011

Project Title:	Hypoxia and SETDB1 up-regulation in liver cancer
Investigator(s):	Wong CM, Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Deregulation of SETDB1 and its functional roles in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Deregulation of HOTTIP long non-coding RNA in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Au L.K.S., Ng I.O.L. and Wong C.M., Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins, Front Med. 2013, 7: 231-41.

Au L.K.S., Ng I.O.L. and Wong C.M., Regulation of EZH2 and its targeted microRNAs, In: Sarkar FH, Epigenetics and Cancer. Springer, 2013, 33-62.

Fan N.Y., Tsang F.H., Tam H.K.A., Au L.K.S., Wong C.C.L., Wei L., Lee M.F., He X.H., Ng I.O.L. and Wong C.M., Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b, Hepatology. 2013, 57: 637-647.

Ho D.W.H., Wong C.M., Sham P.C. and Ng I.O.L., Pathway analysis of genome-wide association data on hepatocellular carcinoma in southern Chinese patients with chronic hepatitis B virus infection., Joint Conference of HGM 2013 and 21st International Congress of Genetics.. 2013.

Li L., Mak K.Y., Shi J., Koon H.K., Leung C.H., Wong C.M., Leung C.W., Mak S.K., Chan N.M.M., Zhong W., Lin K.W., Wu E.X. and Pong P.W.T., Comparative in vitro Cytotoxicity Study on Uncoated Magnetic Nanoparticles: Effects on Cell Viability, Cell Morphology, and Cellular Uptake, Journal of Nanoscience and Nanotechnology. 2012, 12: 9010.

Ma W., Wong C.C.L., Tung K.K., Wong C.M. and Ng I.O.L., RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway, Hepatology. 2012.

Wong C.M., Editorial Board Member, BioMed Research International . 2013.

Wong C.M., Editorial Board Member, World Journal of Hepatology. 2013.

Wong C.M., Interplay between epigenetic and microRNA deregulations in liver cancer metastasis., Sun Yat-Sen University. Guangzhou, China, 2012.

Wong C.M., Interplay between epigenetic and microRNA deregulations in liver cancer metastasis, The Chinese University of Hong Kong. Hong Kong, 2013.

Wong C.M., Kai K.L.A., Tsang F.H. and Ng I.O.L., Regulation of hepatocarcinogenesis by microRNAs., Front Biosci (Elite Ed). 2013, 5: 49-60.

Yang W., Tang H., Zhang Y., Tang X., ZHANG J., Sun L., Yang J., Cui Y., Zhang L., Hirankarn N., Cheng H., Pan H.F., Gao J., Lee T.L., Sheng Y., Lau W.C.S., Li Y., Chan T.M., Yin X., Ying D., Lu Q., Leung A.M.H., Zuo X., Chen X., Tong K.L., Zhou F., Diao Q., Tse N.K.C., Xie H., Mok C.C., Hao F., Wong S.N., Shi B., Lee K.W., Hui Y., Ho M.H.K., Liang B., Lee P.P.W., Cui H., Guo Q., Chung B.H.Y., Pu X., Liu Q., Zhang X., Zhang C., Chong C.Y., Fang H., Wong R.W.S., Sun Y., Mok T.M.Y., Li X.P., Avihingsanon Y., Zhi Z., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Gao F., Shotelersuk V., Kang X., Ying S.K.Y., Zhang L., Wong W.H.S., Zhu D., Fung S.K.S., Zeng F., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Shen N., Tam P.K.H., Sham P.C., Ye D.Q., Yang S., Zhang X. and Lau Y.L., Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians, The American Journal of Human Genetics. 2013, 92: 41-51.

Researcher : Wong ESY

List of Research Outputs

Siu K.Y., Kong D.S., Chan H.Y., Wong E.S.Y., Ip P.P.C., Jiang L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome, In: Siu MK, Kong DS, Chan HY, Wong ES, Ip PP, Jiang L, Ngan HY, Le XF, Cheung AN, PLoS One. 2012.

Siu M.K., Wong E.S.Y., Kong D.S., Chan H.Y., Jiang L., Wong G.W., Lam E.W., Chan K.K., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers, In: Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, Lam EW, Chan KK, Ngan HY, Le XF, Cheung AN, Oncogene. 2012.

Researcher : Wong GW

Project Title:	Adipokines contributing to endometrial carcinogenesis
Investigator(s):	Wong GW, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

List of Research Outputs

Kwan H.T., Chan D.W., Cai C., Mak S.L., Yung M.H., Leung T.H.Y., Wong G.W., Cheung A.N.Y. and Ngan H.Y.S., AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity, PLoS ONE. 2013, 8: e53597.

Mak C.Y., Lee L., Siu K.Y., Wong G.W., Lu X., Ngan H.Y.S., Wong E.S. and Cheung A.N.Y., Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation , Carcinogenesis. 2013, June 2013.

Mak C.Y., Siu K.Y., Wong G.W., Chan K.K.L., Ngan H.Y.S. and Cheung A.N.Y., Dysregulated stemness-related genes in gynecological malignancies., Histology and histopathology. 2012, 27: 1121-1130.

Siu M.K., Wong E.S.Y., Kong D.S., Chan H.Y., Jiang L., Wong G.W., Lam E.W., Chan K.K., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers, In: Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, Lam EW, Chan KK, Ngan HY, Le XF, Cheung AN, Oncogene. 2012.

Wong G.W., Wong I.T., Chu T.C., Ngan H.Y.S. and Cheung A.N.Y., Dysregulation of miR-143 in cervical cancer, AOGIN 2012.

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

Researcher : Wong KY

List of Research Outputs

Tong M., Chan K.W., Bao Y., Wong K.Y., Chen J., Kwan P.S., Tang K.H., Fu L., Qin Y.R., Lok S., Guan X. and Ma S.K.Y., Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma, Cancer Research. 2012, 2012;72: 6024-35.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Cai K
Department:	Pathology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):	Wong MP, Sham MH, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Genetic causes of tyrosine kinase inhibitor resistance in advanced lung cancer patients
Investigator(s):	Wong MP, Lee VHF
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	04/2013

Project Title:	American Association for Cancer Research Annual Meeting 2013; The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through the sonic Hedgehog pathway in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Cai K
Department:	Pathology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):	Wong MP, Sham MH, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Genetic causes of tyrosine kinase inhibitor resistance in advanced lung cancer patients
Investigator(s):	Wong MP, Lee VHF
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	04/2013

Project Title:	American Association for Cancer Research Annual Meeting 2013; The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through the sonic Hedgehog pathway in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Lan Q., Hsiung C.A., Matsuo K., Hong Y.C., Seow A., Wang Z., Hosgood H.D.,. .3.R.D., chen K., Wang J.C., Chatterjee N., Hu W., Wong M.P., Zheng W., Caporaso N., Park J.Y., Chen C.J., Kim Y.H., Kim Y.T. and Landi M.T., Shen H., Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia., Nature Genetics. 2012, 44: 1330-1335.

Tsang J.S., Anthony M., Wong M.P. and Wong C.S., The Use Of Fdg-pet/ct In Extranodal the Use Of Fdg-pet/ct In Extranodal Rosai-dorfman Disease Of Bone , Skeletal Radiol. 2012, 41(6): 715-717.

Walther T.J., Karamanska R., Chan W.Y., Chan M.C.W., Jia N., Air G., Hopton C.L., Wong M.P., Dell A., Peiris J.S.M., Haslam S.M. and Nicholls J.M., Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection, PLoS Pathogen. 2013, 9(3): e1003223.

Wong M.P., Circulating tumor cells as lung cancer biomarkers, In: Wong MP, J Thorac Dis. 2012, 4(6):631-4.

Wong M.P., Deciphering the molecular genetics of lung cancer – The pathologist’s contribution towards personalized medicine, In: Wong MP, Pathology Forum 2013 (25-26 January 2013) Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong. 2013.

Wong M.P., Method comparison of ALK testing and emerging drug targets, In: Wong MP, Seminar in ALK Testing in Non-Small Cell Lung Cancer (18 January 2013) Department of Pathology Hong Kong Sanatorium & Hospital. 2013.

Wong M.P., Molecular profiling and deep sequencing of adenocarcinoma, In: Wong MP, Fifth Asian Pacific Conference: Perspectives in Lung Cancer to be held 24-25 August 2012 in Hong Kong. 2012.

Wong M.P., New targets and ammunition for lung cancer, In: Wong MP, Public Lecture Series - Advancement of targeted therapy (September 15, 2012) The University of Hong Kong Li Ka Shing Faculty of Medicine. 2012.

Wong M.P., Non-tobacco causes of Lung Cancer, In: Wong MP, AM730. 2013.

Wong M.P., Opportunities and Challenges of Lung Cancer Treatment, In: Wong MP, AM730. 2013.

Wong M.P., Liu J., XIAO Z. and Tin P.C., The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through Hedgehog and Notch pathways in lung cancer, In: Wong MP, Liu J, Xiao Z, Tin PC, AACR Annual Meeting 2013 (April 6-10, 2013) Washington, DC. 2013.

Researcher : Wong SY

List of Research Outputs

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

Researcher : XIAO Z

List of Research Outputs

Wong M.P., Liu J., XIAO Z. and Tin P.C., The CD44high/ALDHhigh cell population mediates tumor initiating cell properties through Hedgehog and Notch pathways in lung cancer, In: Wong MP, Liu J, Xiao Z, Tin PC, AACR Annual Meeting 2013 (April 6-10, 2013) Washington, DC. 2013.

Researcher : Yam JWP

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Interplay of caveolin-1 and met receptor in liver cancer metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Impact of nuclear translocation of Met receptor in liver cancer progression
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

Project Title:	Functional significance of nuclear Met-driven nuclear factor kappa B pathway in liver cancer
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Study of COOH-terminal truncated HBx protein-activated oncogenic caveolin-1 in hepatocellular carcinoma
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Liu X., Cheng Q., Geng W., Ling C., Liu Y., Ng K.T.P., Yam J.W.P., Guan X., Lo C.M. and Man K., Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model, Artificial Cells, Nanomedicine, and Biotechnology. 2013, Epub on 2013-06-25.

Shum C.K., Lau C.S.T., TSOI L.S., Chan L.K., Yam J.W.P., Ohira M., Nakagawara A., Tam P.K.H. and Ngan E.S.W., Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation., Oncogene. 2012, doi: 10.1038/onc.2012.437.

Yam J.W.P., Phosphorylation of DLC1 tumor suppressor: its functional impact, Shanghai Pudong Hospital, Fudan University Pudong Medical Center. 2013.

Yam J.W.P., Regulation of DLC1 tumor suppressor by phosphorylation, 19th Hong Kong International Cancer Congress. 2012.

Yam J.W.P., Reviewer, Experimental Cell Research. 2013.

Yam J.W.P., Reviewer, International Journal of Cancer. 2013.

Researcher : Yan HHN

Project Title:	Roles of paracrine Hedgehog signaling on tumorigenesis and cancer stem cells in colorectal cancer
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

Researcher : Yang M

List of Research Outputs

Deng J., Yang M., Liu Y., Wang X., Ko K.H. and Lu L., Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Reply, Arthritis Rheum. 2013, 65(1): 285-7.

Deng J., Liu Y., Yang M., Wang S., Zhang M., Wang X., Ko K.H., Hua Z., Sun L., Cao X. and Lu L., Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response, Arthritis Rheum. 2012, 64(11): 3564-73.

Yang M., Rui K., Wang S. and Lu L., Regulatory B cells in autoimmune diseases, Cell Mol Immunol. 2013, 10(2): 122-32.

Researcher : Yang N

Project Title:	The correlation between gene methylation and treatment sensitivity in breast cancer
Investigator(s):	Yang N, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013
Completion Date:	08/2013

List of Research Outputs

GONG C., Cheung Y.N., Wong S.Y., Man P.S., Yang N., Tsang W.H. and Khoo U.S., Identification of Estrogen Receptor-alpha as a New Translational Target of e1F4E, 2nd Meeting of RNA Biology, Cold Spring Harbor Asia, Suzhou, China. 2012.

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

Researcher : Yeung CW

List of Research Outputs

Yeung C.W., Yau M.M., Ma C.K., Siu T.S., Tam S. and Lam C.W., Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria, In: Yeung CW, Yau MM, Ma CK, Siu TS, Tam S, Lam CW, Hong Kong Med J . 2013, 19(3):272-5.

Yeung C.W., Mak C.M., Lam K.S.L. and Tam S., Hypoglycaemia due to autoimmune insulin syndrome in a 78-year-old Chinese man, Br J Biomed Sci. 2012, 69: 80-2.

Researcher : Yeung YS

List of Research Outputs

Ko F.C.F., Chan L.K., Sze M.F., Yeung Y.S., Tse E.Y.T., Lu P., Yu M.H., Ng I.O.L. and Yam J.W.P., PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis, Nature Communications. 2013, 4: 1618.

Researcher : ZHANG J

List of Research Outputs

ZHANG J., Ng R.K. and Chan L.C., Functions of JARID1B in the Regulation of Hematopoiesis and Leukemogenesis, 18th Congress of European Hematology Association (EHA). Stockholm, Sweden, 2013.

Researcher : ZHANG L

List of Research Outputs

ZHANG L., GONG C., Lau S.L., Yang N., Wong G.W., Cheung A.N.Y., Tsang J.W., Chan K.Y. and Khoo U.S., SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity., Cancer Research. 2013, 73: 246-255.

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