Dept of Pharmacology

DEPT OF PHARMACOLOGY

Researcher : Bai B

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.

Bai B. and Wang Y., Methods to investigate the role of SIRT1 in endothelial senescence, Cell Senescence – methods and protocols . Methods in Molecular Biology, 2013, 965: 327-39.

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : Bai B

List of Research Outputs

Bai B. and Wang Y., Methods to investigate the role of SIRT1 in endothelial senescence, Cell Senescence – methods and protocols . Methods in Molecular Biology, 2013, 965: 327-39.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Researcher : CAI Y

List of Research Outputs

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Genetic ablation of prostaglandin E receptor 4 prevents diet-induced obesity, 14th Hong Kong Pharmacology Society Annual Scientific Meeting, Hong Kong, November 3, 2012, OP3. 2012.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-independent repressor activator protein 1 regulates NF-kB-dependent gene expression in macrophages,, 16th Annual scientific meeting of Institute of cardiovascular science and medicine, Hong Kong, November 17, 2012. CP8. . 2012.

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-Independent Repressor Activator Protein 1 Regulates NF-KB-Dependent Gene Expression in Macrophages, The Institute of Cardiovascular Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP08.

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : CAI Y

List of Research Outputs

Researcher : CHEN S

List of Research Outputs

CHEN S., Tong H.H.Y. and Kwok P.C.L., Spray dried oleanolic acid powder for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

Researcher : CHOW YT

List of Research Outputs

LIANG W., Kwok P.C.L., CHOW Y.T., Tang P., Mason A.J., Chan H.K. and Lam J.K.W., Design of dry powder formulations of pH responsive peptide/plasmid DNA complexes for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Mason A.J., Chan H.K. and Lam J.K.W., Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery, Respiratory Drug Delivery Europe 2013, 21-24 May 2013. Berlin, Germany. 2013.

Researcher : Cai Y

List of Research Outputs

Researcher : Chan EW

Project Title:	Pharmacoepidmiology study of medication errors
Investigator(s):	Chan EW, Wong ICK
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	2012 ASHP Midyear Meeting & Exhibition; IV droperidol and olanzapine as adjuncts to midazolam for the acutely agitated patient: a multi-centre, randomised, double-blind, placebo controlled, clinical trial
Investigator(s):	Chan EW
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2012
Completion Date:	12/2012

List of Research Outputs

Researcher : Chan HK

List of Research Outputs

Chan H.K. and Kwok P.C.L., Novel particle production technologies for inhalation products, In: Paolo Colombo, Daniela Traini, Francesca Buttini, Inhalation Drug Delivery: Techniques and Products. West Sussex, UK, John Wiley and Sons, 2013, 47-62.

Handayani D., Meyer B.J., Chen J., Tang P., Kwok P.C.L., Chan H.K. and Huang X.-.F., The comparison of the effect of oat and Shittake mushroom powder to prevent body weight gain in rats fed high fat diet, Food and Nutrition Sciences. 2012, 3: 1009-1019.

Kwok P.C.L., Salama R.O. and Chan H.K., Proteins, peptides, and controlled-release formulations, In: Paolo Colombo, Daniela Traini, Francesca Buttini, Inhalation Drug Delivery: Techniques and Products. West Sussex, UK, John Wiley and Sons, 2013, 121-144.

LIANG W., Kwok P.C.L., CHOW Y.T., Tang P., Mason A.J., Chan H.K. and Lam J.K.W., Design of dry powder formulations of pH responsive peptide/plasmid DNA complexes for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Mason A.J., Chan H.K. and Lam J.K.W., Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery, Respiratory Drug Delivery Europe 2013, 21-24 May 2013. Berlin, Germany. 2013.

Tang P., Kwok P.C.L., Tong Z., Yang R., Raper J.A. and Chan H.K., Does the United States Pharmacopeia throat introduce de-agglomeration of carrier-free powder from inhalers?, Pharmaceutical Research. 2012, 29: 1797-1807.

Wong J., Kwok P.C.L., Ali A., Dehghani F. and Chan H.K., Effect of crystallinity on electrostatic charging in DPI formulations, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

Wong J., Kwok P.C.L., Fathi A., Deghani F. and Chan H.K., Electrostatic properties of dry powder inhaler formulations: Effect of crystallinity, Respiratory Drug Delivery Europe 2013, Berlin, Germany, 21-24 May 2013.

Researcher : Chan KYC

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.

Chan K.Y.C. and Vanhoutte P.M.G.R., Hypoxia, vascular smooth muscles and endothelium, Acta Pharmaceutica Sinca B. 2012, 1: 1-7.

Researcher : Chan KYC

List of Research Outputs

Chan K.Y.C. and Vanhoutte P.M.G.R., Hypoxia, vascular smooth muscles and endothelium, Acta Pharmaceutica Sinca B. 2012, 1: 1-7.

Researcher : Chan WLP

List of Research Outputs

Chan W.L.P., Care of the Elderly, HKU - Shenzhen Hospital Professional Deveopment Seminar. 2013.

Chan W.L.P., Clinical Pharmacy in Hong Kong, HKU - Shenzhen Hospital Professional Development Seminar. 2013.

Chan W.L.P., Medication Reconciliation, HKU - Shenzhen Hospital Professional Development Seminar. 2013.

Chan W.L.P., Chung C.K. and Wong V., Therapeutic Debate, Hong Kong Pharmacy Conference 2013. 2013.

Chan W.L.P., Workshop on Care of the Elderly, HKU - Shenzhen Hospital Professional Development Seminar. 2013.

Chan W.L.P., Workshop on Medication Reconciliation, HKU - Shenzhen Hospital Professional Development Seminar. 2013.

Chan W.L.P., Workshop on Renal Medicines (on the behalf of Prof. Alan Lau), HKU - Shenzhen Hospital Professioinal Development Seminar. 2013.

Chan W.L.P., 香港長者安老院患者的用藥安全管理, 中國藥劑科建設會, 2012.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., Drug wastage among the elderly living in old aged homes in Hong Kong, Hong Kong Pharm J. 2013, 20: 16-18.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., The pharmaceutical services to the elderly in the old aged homes in Hong Kong: a scope exercise. , Hong Kong Pharm J. 2013, 20: 11-15.

Researcher : Chan WYE

Project Title:	Pharmacoepidmiology study of medication errors
Investigator(s):	Chan EW, Wong ICK
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	2012 ASHP Midyear Meeting & Exhibition; IV droperidol and olanzapine as adjuncts to midazolam for the acutely agitated patient: a multi-centre, randomised, double-blind, placebo controlled, clinical trial
Investigator(s):	Chan EW
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2012
Completion Date:	12/2012

List of Research Outputs

Chan W.Y.E., Clinical Pharmacy in the Emergency Department. Clinical Pharmacy Conference, Clinical Pharmacy Conference. The University of Hong Kong Shenzhen Hospital. 2013.

Chan W.Y.E., Combination therapy is effective and safe for sedating acutely agitated patients in the ER, American College of Emergency Physicians, Reuters. 2012.

Chan W.Y.E., Knott J.C., Liew D., Taylor D.M.C.D. and Kong D.C.M., Cost-minimisation analysis of midazolam versus droperidol in the management of acute agitation in the emergency department., J Pharm Prac Res. 2012, 42: 11-16.

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Chan W.Y.E., Kong D.C.M., Knott J.C. and Castle D.J., Ethical issues in researching interventions for behavioural disturbances in psychotic disorders, Asia Pac Psychiatry. 2012, 4: 140-143.

Chan W.Y.E., Taylor D.M.C.D., Knott J.C., Phillips G.A., Castle D.J. and Kong D.C.M., IV droperidol and olanzapine as adjuncts to midazolam for the acutely agitated patient: a multi-centre, randomised, double-blind, placebo-controlled, clinical trial., Australasian College for Emergency Medicine, Annual Scientific Meeting, Sydney; Schizophrenia International Research Society Conference, Florence; American Society of Hospital Pharmacists Midyear, Las Vegas. 2012.

Chan W.Y.E., Insomnia and sleeping pills, MingPao News. 2013.

Chan W.Y.E., Taylor D.M.C.D., Knott J.C., Phillips G.A., Castle D.J. and Kong D.C.M., Intravenous Droperidol Or Olanzapine As Adjuncts To Midazolam For The Acutely Agitated Patient: A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial – Reply to letter to the editor. , Ann Emerg Med. 2013.

Chan W.Y.E., Taylor D.M.C.D., Knott J.C., Phillips G.A., Castle D.J. and Kong D.C.M., Intravenous Droperidol or Olanzapine as Adjuncts to Midazolam for the Acutely Agitated Patient: A Multi-Centre, Randomised, Double-blind, Placebo-controlled Clinical Trial. , Ann Emerg Med. 2013, 61(1):72-81.

Chan W.Y.E., Learning from abroad. Clinical Pharmacy in Australia, Clinical Pharmacy Conference. The University of Hong Kong Shenzhen Hospital. 2013.

Chan W.Y.E., Taylor D.M.C.D., Phillips G.A., Castle D., Knott J.C. and Kong D.C.M., May I have your consent? Informed consent in clinical trials – feasibility in emergency situations, J Psychr Intensive Care. 2012, 7: 109-113.

Chan W.Y.E., Medication Related Problems in elderly Patients with Diabetes - Pilot Data from a New Clinical Pharmacy Service in the Outpatient Setting, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 36.

Chan W.Y.E., Medication related problems in elderly patients with diabetes. Pilot data from a new clinical pharmacy service in the outpatients setting., Eighth International Symposium on Healthy Aging. How to Age with Finesse, Hong Kong. 2013.

Chan W.Y.E., Knott J.C., Liew D., Taylor D.M.C.D. and Kong D.C.M., Pharmacoeconomic evaluation of midazolam versus droperidol in the management of acute agitation in the Emergency Department, Asian Conference for Emergency Medicine, Bangkok . 2012.

Chan W.Y.E., The Pharmaceutical Society and HKU unveil the situation of drug wastage among the elderly living at old age homes in Hong Kong, The University of Hong Kong. 2013.

Chan W.Y.E., The importance of clinical research, 臨床研究的重要性, RTHK. 2013.

Chan W.Y.E., Knott J.C., Liew D., Taylor D.M.C.D. and Kong D.C.M., The pharmacoeconomics of managing acute agitation in the Emergency Department: what do we know and how do we approach it?, Exp Rev Pharmacoeconomics. 2012, 12: 589-595.

Chan W.Y.E., Taylor D.M.C.D., Knott J.C. and Kong D.C.M., The use of olanzapine via an unapproved route in the management of acute agitation, Asian Conference for Emergency Medicine, Bangkok . 2012.

Chan W.Y.E., What is the issue with vitamin C combination tablets? , 维C银翘片有问题吗?, 人民日报, 2013.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., Drug wastage among the elderly living in old aged homes in Hong Kong, Hong Kong Pharm J. 2013, 20: 16-18.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., The pharmaceutical services to the elderly in the old aged homes in Hong Kong: a scope exercise. , Hong Kong Pharm J. 2013, 20: 11-15.

Researcher : Che CM

Project Title:	Blue light photoluminescent materials
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Hung Hing Ying Physical Sciences Research Fund
Start Date:	02/1999

Project Title:	Research and development of luminescent biosensors for drug screening and environmental monitoring
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	11/2002

Project Title:	Functional nanomaterials research
Investigator(s):	Che CM, Chan MCW
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Research & Development of New Materials for Printable Electronics
Investigator(s):	Che CM, Vellaisamy ALR, Kwok CC, Kui CF, Ma CW
Department:	Chemistry
Source(s) of Funding:	Platform Research Projects
Start Date:	07/2008

Project Title:	High-Performance Tandem Mass Spectrometry Facility for Functional Proteomics and Metabolomics
Investigator(s):	Che CM, Cheah KSE, Ma CY, Lee HC, Chan D, Tanner JA, Xu A, Sun H, Wong WT, Poon RTP, Wang Y, Ng KM, Chu IK, Siu AFM, Chen SF, Chye ML, Lo CSC
Department:	Chemistry
Source(s) of Funding:	UGC One-off Special Equipment Grant Scheme
Start Date:	12/2008

Project Title:	Green Chemistry: Application of Nanotechnology in the Development of Highly Efficient and Environmental Friendly Chemical Synthesis
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2009

Project Title:	Green Chemistry: Application of Nanotechnology in the Development of Highly Efficient and Environmental Friendly Chemical Synthesis
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2009

Project Title:	Research & Development of New Materials for Printable Electronics
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme (NAMI)
Start Date:	07/2009

Project Title:	New Materials for Organic/polymer Base Photovoltaic Cells
Investigator(s):	Che CM, Kwok CC, Kui CF
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	10/2009

Project Title:	Research & Development of New Materials for Printable Electronics
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme (NAMI)
Start Date:	11/2009

Project Title:	Phosphorescent Metal Complexes with d8 and d10 Electronic Configurations. Photochemistry, and Self-Assembled Nanostructure
Investigator(s):	Che CM, Lu W, Tong SM
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	New Materials for Organic/polymer Base Photovoltaic Cells
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads
Investigator(s):	Che CM, Sun RWY, Vanhoutte PMGR, Lin MC, Poon RTP, Wang Y, Siu AFM, Ma DL, Leung CH, Lau CK
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 2)
Start Date:	03/2010
Completion Date:	08/2012

Project Title:	Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2010

Project Title:	New Materials for Organic/polymer Base Photovoltaic Cells
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	06/2010

Project Title:	Transition Metal-Catalysed Oxygenation Reactions. Biomimetic and Photochemical Approaches
Investigator(s):	Che CM, Wong ELM, Guo Z, Ng KM
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Research and development of phosphorescent organic light emitting diode (OLED) materials and prototype devices for lighting applications
Investigator(s):	Che CM, Kwok CC, Kui CF, Low KH, Cheng G, Ma CW
Department:	Chemistry
Source(s) of Funding:	Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:	03/2011

Project Title:	Solvent-Free Metal Nanoparticle-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry: Applications of Noble Metal Nanoparticles to the Molecular Imaging of Herbal Tissues, and Investigation of the Ion Desorption Mechanism(s)
Investigator(s):	Che CM, Ng KM
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2011

Project Title:	Research and development of phosphorescent organic light emitting diode (OLED) materials and prototype devices for lighting applications
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	08/2011

Project Title:	Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	08/2011

Project Title:	Research and development of phosphorescent organic light emitting diode (OLED) materials and prototype devices for lighting applications.
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	08/2011

Project Title:	Direct Sample Analysis by Mass Spectrometry: Development and Analytical Application of Tip-Spray Ionization MS and Imaging MS
Investigator(s):	Che CM, Ng KM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	10/2011
Completion Date:	12/2012

Project Title:	Research and development of a steroidal saponin for therapeutic use
Investigator(s):	Che CM, Sy LK, Lok CN
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	01/2012
Completion Date:	12/2012

Project Title:	Metal-organic materials and prototype device for organic photovoltaic cell application (ITS/310/11)
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	04/2012

Project Title:	Metal-organic materials and prototype device for organic photovoltaic cell application
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	04/2012
Completion Date:	10/2013

Project Title:	Synthesis of novel organometallic metal complexes with fused-thiophene ligands for photovoltaic application
Investigator(s):	Che CM, Low KH
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	R&D Laboratory for Testing of Chinese Medicine
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	The Hong Kong Jockey Club Charities Trust - General Award
Start Date:	11/2012

Project Title:	Study on High-Valent Iridium Complexes: Synthesis, Characterization and Reactivity towards Oxidative C-H Bond Functionalization
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Molecular Design of New Classes of Phosphorescent d8 Metal Complexes with Long-Lived Emissive Excited States and Application Studies in Photo-Catalysis, Luminescent Sensors, and Molecular Self-Assembly
Investigator(s):	Che CM, Ma C
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Medicinal Chemistry of Gold Complexes
Investigator(s):	Che CM, Sun RWY
Department:	Chemistry
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2013

Project Title:	Phosphorescent Metal Complexes for Solar Energy Conversion Reactions
Investigator(s):	Che CM, Phillips DL
Department:	Chemistry
Source(s) of Funding:	SRFDP & RGC ERG Joint Research Scheme
Start Date:	03/2013

Project Title:	Therapeutic applications of timosaponins and their synthetic derivatives
Investigator(s):	Che CM, Sy LK, Lok CN
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	03/2013

Project Title:	The HONG KONG – SHANGHAI – MÜNSTER Joint Trilateral Symposium on Organometallic Chemistry; Iron-Catalyzed C-H Functionalization
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

Project Title:	Therapeutic Applications of Timosaponins and Their Synthetic Derivatives
Investigator(s):	Che CM, Sy LK, Lok CN
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2013

List of Research Outputs

Lai S.L., TONG W.Y., Kui C.F., Chan M.Y., Kwok C.C. and Che C.M., High Efficiency White Organic Light-Emitting Devices Incorporating Yellow Phosphorescent Platinum(II) Complex and Composite Blue Host, In: Shiu-Lun Lai , Wai-Yip Tong , Steven C. F. Kui , Mei-Yee Chan , Chi-Chung Kwok , and Chi-Ming Che, Adv. Funct. Mater.. 2013, 23.

Siu A.F.M., Lin I.W.S., Yan K., Lok C.N., Low K.H., Leung T.Y.C.L., Lam T.L. and Che C.M., Anticancer dirhodium(II,II) carboxylates as potent inhibitors of ubiquitin-proteasome system, Chemical Science. 2012.

Researcher : Chen J

List of Research Outputs

Chen J., Xu A., Liu J., Lam K.S.L. and Wang Y., Adipose-derived Stromal Cells Derived from Adiponectin Deficient Mice Promote the Development of Metaplastic Mammary Tumors, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 67.

Researcher : Cho CH

Project Title:	Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
Investigator(s):	Cho CH
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2004

Project Title:	Adrenaline and its receptor activation on colon cancer growth
Investigator(s):	Cho CH
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2006

List of Research Outputs

Chu K.M., Cho C.H. and Shin V.Y., Nicotine and gastrointestinal disorders: its role in ulceration and cancer development, Current Pharmaceutical Design. 2013, 19: 5-10.

Huang F.Y., Chan A.O.O., Lo C.L.R., Rashid A., Wong D.K.H., Cho C.H., Lai C.T.M. and Yuen R.M.F., Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice, European Journal of Cancer. 2013, 49(12): 2760-70.

Researcher : Chui SLC

List of Research Outputs

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Researcher : Chung CK

List of Research Outputs

Chan W.L.P., Chung C.K. and Wong V., Therapeutic Debate, Hong Kong Pharmacy Conference 2013. 2013.

Researcher : Deng H

List of Research Outputs

Deng H., Tomlinson B., Lam T.H., Jong S.D.E. and Thomas G.N., Gene Co-Expression Network Analysisi to Identify Genes Related to Blood Pressure Control by RAS Blockers, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 52.

Researcher : Dufay S

Project Title:	Quantitation of Dexmedetomidine in plasma for pharmacokinetic study after intranasal administration in healthy volunteers
Investigator(s):	Dufay S, Irwin MG, Wong ICK
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Researcher : FAN P

List of Research Outputs

Fan P., Berger T., Xu A., Mak T.W. and Wang Y., Lipocalin-2 Acts as a Stromal Factor to Promote Mammary Carcinogenesis by Activating Phospholipase A2 in Breast Cancer Cells, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 164.

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : Fan P

List of Research Outputs

Researcher : Fan P

List of Research Outputs

Researcher : Grant AJ

List of Research Outputs

Grant A.J., The use of Problem Based Learning in Pharmacy Education, Chinese Pharmaceutical University, Nanjing, China. 2012.

Researcher : He Y

List of Research Outputs

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Researcher : Ho YW

List of Research Outputs

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Researcher : Huang B

List of Research Outputs

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : KONG WCB

List of Research Outputs

KONG W.C.B., Man G.S.K. and Leung S.W.S., Investigation On The Involvement Of Reactive Oxygen Species And Mitogen-Activated Protein Kinase In Endothelium-Dependent Relaxation In Spontaneously Hypertensive Rats, Dublin, Ireland , 6th European Workshop on Cannabinoid Research . 2013.

Researcher : Kwok PCL

Project Title:	Inhalable dry powder aerosols for influenza prevention or treatment
Investigator(s):	Kwok PCL, Yen H, Peiris JSM
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Respiratory Drug Delivery 2012 Arizona Spray freeze dried large porous particles for nano drug delivery by inhalation
Investigator(s):	Kwok PCL
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	Inhalable oleanolic acid dry powder for lung diseases
Investigator(s):	Kwok PCL
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

Project Title:	Respiratory Drug Delivery Europe 2013; Electrostatic Properties of Dry Powder Inhaler Formulations: Effect of Crystallinity
Investigator(s):	Kwok PCL
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

Buttini F., Colombo G., Kwok P.C.L. and Wong T.W., Aerodynamic assessment and current pharmacopoeial methods, In: Paolo Colombo, Daniela Traini, Francesca Buttini, Inhalation Drug Delivery: Techniques and Products. West Sussex, UK, John Wiley and Sons, 2013, 91-119.

CHEN S., Tong H.H.Y. and Kwok P.C.L., Spray dried oleanolic acid powder for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

Chan H.K. and Kwok P.C.L., Novel particle production technologies for inhalation products, In: Paolo Colombo, Daniela Traini, Francesca Buttini, Inhalation Drug Delivery: Techniques and Products. West Sussex, UK, John Wiley and Sons, 2013, 47-62.

Chan J.G.Y., Traini D., Chan H.-.K., Young P.M. and Kwok P.C.L., Delivery of high solubility polyols by vibrating mesh nebuliser to enhance mucociliary clearance, Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2012, 25.

Handayani D., Meyer B.J., Chen J., Tang P., Kwok P.C.L., Chan H.K. and Huang X.-.F., The comparison of the effect of oat and Shittake mushroom powder to prevent body weight gain in rats fed high fat diet, Food and Nutrition Sciences. 2012, 3: 1009-1019.

Kwok P.C.L. and Morton D.A.V., Basics of aerosol particles, Pharmaceutical Aerosol Product Workshop, The University of Hong Kong, Hong Kong SAR, 24 June 2013. 2013.

Kwok P.C.L., Protein nanoparticles for drug delivery and latest trends in nanomedicines, NAMI Winter School 2013, Nano and Advanced Materials (NAMI) Institute Limited, The Hong Kong University of Science of Technology, Hong Kong SAR, 26 January 2013. 2013.

Kwok P.C.L., Salama R.O. and Chan H.K., Proteins, peptides, and controlled-release formulations, In: Paolo Colombo, Daniela Traini, Francesca Buttini, Inhalation Drug Delivery: Techniques and Products. West Sussex, UK, John Wiley and Sons, 2013, 121-144.

Kwok P.C.L., Respiratory medicines, Clinical Pharmacy Conference 国际临床药师学术会, The Hong Kong University-Shenzhen Hospital, Shenzhen, China, 17 March 2013. 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Tang P., Mason A.J., Chan H.K. and Lam J.K.W., Design of dry powder formulations of pH responsive peptide/plasmid DNA complexes for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Mason A.J., Chan H.K. and Lam J.K.W., Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery, Respiratory Drug Delivery Europe 2013, 21-24 May 2013. Berlin, Germany. 2013.

Tang P., Kwok P.C.L., Tong Z., Yang R., Raper J.A. and Chan H.K., Does the United States Pharmacopeia throat introduce de-agglomeration of carrier-free powder from inhalers?, Pharmaceutical Research. 2012, 29: 1797-1807.

Wong J., Kwok P.C.L., Ali A., Dehghani F. and Chan H.K., Effect of crystallinity on electrostatic charging in DPI formulations, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

Wong J., Kwok P.C.L., Fathi A., Deghani F. and Chan H.K., Electrostatic properties of dry powder inhaler formulations: Effect of crystallinity, Respiratory Drug Delivery Europe 2013, Berlin, Germany, 21-24 May 2013.

Researcher : LAN Y

List of Research Outputs

LAN Y., Yam W.C., LAM T.H., SIU K.H., Mason A.J. and Lam J.K.W., Investigation of the structural contributions to the antimicrobial peptides activity against Mycobacterium Tuberculosis, Tuberculosis – Can we beat it? The Royal College of Pathologists London, 21 March 2013, UK. 2013.

Lan Y., Yam W.C., Siu G. and Lam J.K.W., Development of Novel Therapeutics against Tuberculosis, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 132.

Tripathy N., Lan Y., Lam J.K.W., Vanhoutte P.M.G.R. and Hahn Y.B., Comprehensive Study on the Toxicology of Surface-Coated ZnO Nanoparticles in Human Alveolar Adenocarcinoma (A549) Cells, Science of Advanced Materials. 2013, 5: 421-429.

Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L., Jumagulova E., Kozlowska J., Patel J., McIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K.W., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and anti-bacterial, -plasmodium, - and –cancer potency of cationic α-helical peptides, The Journal of Biological Chemistry. 2012, 271: 34120-34133.

Researcher : LIANG C

List of Research Outputs

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4, Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, 33: 777-784.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing nadph oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol. 2013, 33: 777-784.

Researcher : LIANG W

List of Research Outputs

LIANG W. and Lam J.K.W., Amphipathic peptide-mediated delivery of siRNA for antiviral therapy against influenza., Inhalation Asia 2013, 26-28 June 2013, Hong Kong. 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Tang P., Mason A.J., Chan H.K. and Lam J.K.W., Design of dry powder formulations of pH responsive peptide/plasmid DNA complexes for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Mason A.J., Chan H.K. and Lam J.K.W., Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery, Respiratory Drug Delivery Europe 2013, 21-24 May 2013. Berlin, Germany. 2013.

Liang W. and Lam J.K.W., Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems, In: Brian Ceresa, Molecular Regulation of Endocytosis. InTech, 2012, Chapter 17: 421-467.

Liang W., Lau P.N., Mason J., Poon L.L.M. and Lam J.K.W., Inhibition of influenza viral replication using siRNA delivered by pH-responsive peptides, 8th International Conference and Exhibition - RNAi2013, March 19-21, 2013, Oxford UK. 2013.

Liang W., Mason A.J. and Lam J.K.W., The Investigation of pH Responsive Amphipathic Peptide for Gene Silencing, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 134.

Liang W., MASON A.J. and Lam J.K.W., Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides, In: Jurgen Moll Riccardo Colombo, Target Identification and Validation in Drug Discovery, Methods and Protocols. New York, Humana Press, 2013, 986: 73-87.

YE Y., Xu Y., Liang W., Leung G.P.H., Cheung K.H., Zheng C., Chen F. and Lam J.K.W., DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells, Journal of Drug Targeting. 2013, 21: 474-486.

Researcher : LIANG Y

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Researcher : LIN HYA

List of Research Outputs

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Researcher : LIU TC

List of Research Outputs

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4, Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, 33: 777-784.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing nadph oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol. 2013, 33: 777-784.

Researcher : Lam JKW

Project Title:	Investigation of siRNA delivery to macrophages: potential novel therapy for the treatment of tuberculosis
Investigator(s):	Lam JKW, Yam WC
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011

Project Title:	The investigation of antimicrobial peptide as novel therapy for mycobacterium tuberculosis
Investigator(s):	Lam JKW, Yam WC
Department:	Pharmacology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:	10/2011

Project Title:	Chitosan-based dry powder nasal formulation for delivering therapeutic peptides – development of technology platform for intranasal delivery study
Investigator(s):	Lam JKW, Kwok PCL
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

Project Title:	The use of N-acetyl cysteine grafted chitosan as mucosal adjuvant in intranasal formulation of DNA vaccine
Investigator(s):	Lam JKW
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013

Project Title:	Respiratory Drug Delivery Europe 2013; Spray dried powder and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery
Investigator(s):	Lam JKW
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

Casettari L., Vllasaliu D., Lam J.K.W., Soliman M. and Illum L., Biomedical applications of amino acid modified chitosans: A review, Biomaterials. 2012, 33: 7565-7583.

LAN Y., Yam W.C., LAM T.H., SIU K.H., Mason A.J. and Lam J.K.W., Investigation of the structural contributions to the antimicrobial peptides activity against Mycobacterium Tuberculosis, Tuberculosis – Can we beat it? The Royal College of Pathologists London, 21 March 2013, UK. 2013.

LIANG W. and Lam J.K.W., Amphipathic peptide-mediated delivery of siRNA for antiviral therapy against influenza., Inhalation Asia 2013, 26-28 June 2013, Hong Kong. 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Tang P., Mason A.J., Chan H.K. and Lam J.K.W., Design of dry powder formulations of pH responsive peptide/plasmid DNA complexes for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

LIANG W., Kwok P.C.L., CHOW Y.T., Mason A.J., Chan H.K. and Lam J.K.W., Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery, Respiratory Drug Delivery Europe 2013, 21-24 May 2013. Berlin, Germany. 2013.

Lam J.K.W., Amphipathic peptide-mediated delivery of siRNA for antiviral therapy against influenza. , Inhalation Asia 2013, The University of Hong Kong, Hong Kong . 2013.

Lam J.K.W., Faculty Teaching Medal 2012, Li Ka Shing Faculty of Medicine, HKU. 2012.

Lam J.K.W., King's/HKU Fellowship Awards 2013/14, The University of Hong Kong. 2013.

Lan Y., Yam W.C., Siu G. and Lam J.K.W., Development of Novel Therapeutics against Tuberculosis, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 132.

Liang W. and Lam J.K.W., Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems, In: Brian Ceresa, Molecular Regulation of Endocytosis. InTech, 2012, Chapter 17: 421-467.

Liang W., Lau P.N., Mason J., Poon L.L.M. and Lam J.K.W., Inhibition of influenza viral replication using siRNA delivered by pH-responsive peptides, 8th International Conference and Exhibition - RNAi2013, March 19-21, 2013, Oxford UK. 2013.

Liang W., Mason A.J. and Lam J.K.W., The Investigation of pH Responsive Amphipathic Peptide for Gene Silencing, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 134.

Liang W., MASON A.J. and Lam J.K.W., Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides, In: Jurgen Moll Riccardo Colombo, Target Identification and Validation in Drug Discovery, Methods and Protocols. New York, Humana Press, 2013, 986: 73-87.

Tripathy N., Lan Y., Lam J.K.W., Vanhoutte P.M.G.R. and Hahn Y.B., Comprehensive Study on the Toxicology of Surface-Coated ZnO Nanoparticles in Human Alveolar Adenocarcinoma (A549) Cells, Science of Advanced Materials. 2013, 5: 421-429.

Vermeer L.S., Lan Y., Abbate V., Ruh E., Bui T.T., Wilkinson L., Jumagulova E., Kozlowska J., Patel J., McIntyre C.A., Yam W.C., Siu G.K.H., Atkinson R.A., Lam J.K.W., Bansal S.S., Drake A.F., Mitchell G.H. and Mason A.J., Conformational flexibility determines selectivity and anti-bacterial, -plasmodium, - and –cancer potency of cationic α-helical peptides, The Journal of Biological Chemistry. 2012, 271: 34120-34133.

XU Y., Lam J.K.W., Wong I.C.K. and lessa N., Practical Therapeutics: benefits of buccal midazolam in paediatric patients benefits of buccal midazolam in paediatric patients, Hospital Pharmacy Europe. 2012, 65: 55-8.

YE Y., Xu Y., Liang W., Leung G.P.H., Cheung K.H., Zheng C., Chen F. and Lam J.K.W., DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells, Journal of Drug Targeting. 2013, 21: 474-486.

Researcher : Lam MPS

Project Title:	An evaluation of the prescribing appropriateness of Hong Kong elderly and the prevalence of preventable drug related admissions to hospital
Investigator(s):	Lam MPS, Cheung BMY, Wong ICK
Department:	Pharmacology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	01/2013

List of Research Outputs

Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Evalution of Beers and Stopp/Start Criteria for Prescribing Appropriateness Among Hong Kong Elderly, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 60.

Lam M.P.S., Yeung C.K. and Cheung B.M.Y., Pharmacogenetics of Allopurinol-Making an Old Drug Safer, The Journal of Clinical Pharmacology. 2013, 53(7): 675-679.

Researcher : Lan Y

List of Research Outputs

Lan Y., Yam W.C., Siu G. and Lam J.K.W., Development of Novel Therapeutics against Tuberculosis, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 132.

Researcher : Lau CY

List of Research Outputs

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Researcher : Law KM

List of Research Outputs

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : Lee YKM

List of Research Outputs

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.

Researcher : Leung GPH

Project Title:	Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4)
Investigator(s):	Leung GPH
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Project Title:	Abacavir, an antiviral nucleoside analogue, increases the risk of cardiovascular events by causing endothelial dysfunction
Investigator(s):	Leung GPH, Vanhoutte PMGR, Xia Z
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2009
Completion Date:	10/2012

Project Title:	Protective effect of ergothioneine on endothelial cell function against oxidative stress
Investigator(s):	Leung GPH, Xia Z
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	Re-uptake system of epoxyeicosatrienoic acids in vascular cells
Investigator(s):	Leung GPH
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

Project Title:	Inhibitory effect of emodin on nucleoside transporters: potential implication in cancer therapy
Investigator(s):	Leung GPH
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2012

Project Title:	Vascular protective effect of ADTM
Investigator(s):	Leung GPH
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Chan E., Chan J.Y., Wu J.H., Wan C.W., Leung G.P.H., Lee S.M.Y., Kwan Y.W. and Chan S.W., Serum nitric oxide synthase activity is a novel predictor of impaired vasorelaxation in rats., Clinical and Experimental Pharmacology and Physiology. 2012, 39: 894-896.

Chan Y.S., Cheng L.N., Wu J.H., Chan E., Kwan Y.W., Lee S.M.Y., Leung G.P.H., Yu P.H.F. and Chan S.W., A review of the pharmacological effect of Arctium Lappa (burdock), Inflammopharmacology . 2012, 19: 245-254.

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Leung G.P.H., Academic Editor, Cardiology and Angiology: An International journal. 2013.

Leung G.P.H., Editorial Board Member, Cardiovascular Pharmacology: Open Access. 2013.

Leung G.P.H., Editorial Board Member, International Journal of Pharmacological Sciences. 2013.

Li R.W.S., Wang Y., Lee S.M.Y., Chan S.W., Kwan Y.W. and Leung G.P.H., The vasodilatory and anti-inflammatory effects of ADTM, a synthetic dimer of Danshensu and tetramethlpyrazine, Fifth Scientific Meeting of Asian Society for Vascular Biology, Xian China, 27-29 October 2012. 78.

Li W.S.R., Yang C., Kwan Y.W., Chan S.W., Lee S.M.Y. and Leung G.P.H., Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells, Frontiers in Cardiovascular and Smooth Muscle Pharmacology. 2013, 4: 14.

Lo C., Lee S.S., Leung G.P.H. and Leung S.W.S., Effects of Antiretroviral Drugs on Inflammation of Human Endothelial Cells, 17th Research Postgraduate Symspsium, December 12 & 13, 2012 Hong Kong. 2012, 98.

SONG T., Lee C.K.F., Sze C.W., Tong Y., Tang S.C.W., Leung G.P.H. and Zhang Y., A Novel Method for Quality Control of Chinese Medicines in vivo/vitro. , In: Song TH, Calvin Lee KF, Stephen Sze CW, Tong Y, Sydney Tang CW, George Leung PH, Kalin Zhang YB*., 11st Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Aug 21-23, 2012, Macao, China. . 2012.

Seto S.W., Au A.L.S., Poon C.C.W., Zhang Q., Li R.W.S., Yeung J.H.K., Kong S.K., Ngai S.M., Wan S., Ho H.P., Lee S.M.Y., Hoi M.P.M., Chan S.W., Leung G.P.H. and Kwan Y.W., Acute simvastatin inhibits KATP channels of porcine coronary artery myocytes, PLOS One. 2013, 8: e66404.

YE Y., Xu Y., Liang W., Leung G.P.H., Cheung K.H., Zheng C., Chen F. and Lam J.K.W., DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells, Journal of Drug Targeting. 2013, 21: 474-486.

Zhou X., Chan S.W., Tseng H.L., Deng Y., Hoi P.M., Choi P.S., Or P.M., yang J.M., Lam F.F., Lee S.M.Y., Leung G.P.H., Kong S.K., Ho H.P., Kwan Y.W. and yeung J.H., Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions, Phytomedicine. 2012, 19: 1263-1269.

Researcher : Leung SWS

Project Title:	Assessment of vascular reactivity in protease inhibitor treatment using a rat model
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	08/2012

Project Title:	Vascular effects of milk casein
Investigator(s):	Leung SWS
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	6th European Workshop on Cannabinoid Research ; Investigation On The Involvement Of Reactive Oxygen Species And Mitogen-Activated Protein Kinase In Endothelium-Dependent Relaxation In Spontaneously Hypertensive Rats
Investigator(s):	Leung SWS
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	Effects of non-nucleoside and nucleoside reverse transcriptase inhibitors on vascular inflammation
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

KONG W.C.B., Man G.S.K. and Leung S.W.S., Investigation On The Involvement Of Reactive Oxygen Species And Mitogen-Activated Protein Kinase In Endothelium-Dependent Relaxation In Spontaneously Hypertensive Rats, Dublin, Ireland , 6th European Workshop on Cannabinoid Research . 2013.

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Lo C., Lee S.S., Leung G.P.H. and Leung S.W.S., Effects of Antiretroviral Drugs on Inflammation of Human Endothelial Cells, 17th Research Postgraduate Symspsium, December 12 & 13, 2012 Hong Kong. 2012, 98.

QU C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha, European Journal of Pharmacology. 2012, 696: 101-110.

YAU K.H., Mak J.C.W., Leung S.W.S., Yang D. and Vanhoutte P.M.G.R., A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat, PLOS One. 2012, 7: e45340.

ZHAO Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of α1-adrenergic receptors causes thromboxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Experimental Biology 2013, Boston, MA, USA. 2013.

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Experimental Biology 2013, Boston MA, USA. 2013.

Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Endothelial Nitric Oxide Synthase-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat, J Pharmacol Exp Ther. 2013, 344: 15-22.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxation induced by mild hypothermia in the rat aorta, 17th Research Postgraduate Symposium, Hong Kong December 12 & 13, 2012. 192.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Fifth Scientific Meeting of Asian Society for Vascular Biology, Xian China 27-29 October 2012. 30.

Researcher : Li J

List of Research Outputs

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Researcher : Li RWS

Project Title:	6th European Congress of Pharmacology ADTM, a synthetic dimer of Danshensu and tetramethylpyrazine, induces relaxation in rat mesenteric arteries
Investigator(s):	Li WSR
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012

List of Research Outputs

Li R.W.S., Wang Y., Lee S.M.Y., Chan S.W., Kwan Y.W. and Leung G.P.H., The vasodilatory and anti-inflammatory effects of ADTM, a synthetic dimer of Danshensu and tetramethlpyrazine, Fifth Scientific Meeting of Asian Society for Vascular Biology, Xian China, 27-29 October 2012. 78.

Researcher : Li WSR

Project Title:	6th European Congress of Pharmacology ADTM, a synthetic dimer of Danshensu and tetramethylpyrazine, induces relaxation in rat mesenteric arteries
Investigator(s):	Li WSR
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012

List of Research Outputs

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Li W.S.R., Yang C., Kwan Y.W., Chan S.W., Lee S.M.Y. and Leung G.P.H., Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells, Frontiers in Cardiovascular and Smooth Muscle Pharmacology. 2013, 4: 14.

Researcher : Liang W

List of Research Outputs

LIANG W. and Lam J.K.W., Amphipathic peptide-mediated delivery of siRNA for antiviral therapy against influenza., Inhalation Asia 2013, 26-28 June 2013, Hong Kong. 2013.

Liang W. and Lam J.K.W., Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems, In: Brian Ceresa, Molecular Regulation of Endocytosis. InTech, 2012, Chapter 17: 421-467.

Liang W., Mason A.J. and Lam J.K.W., The Investigation of pH Responsive Amphipathic Peptide for Gene Silencing, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 134.

Researcher : Liang Y

List of Research Outputs

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Researcher : Liu J

List of Research Outputs

Chen J., Xu A., Liu J., Lam K.S.L. and Wang Y., Adipose-derived Stromal Cells Derived from Adiponectin Deficient Mice Promote the Development of Metaplastic Mammary Tumors, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 67.

Researcher : Lo C

List of Research Outputs

Lo C., Lee S.S., Leung G.P.H. and Leung S.W.S., Effects of Antiretroviral Drugs on Inflammation of Human Endothelial Cells, 17th Research Postgraduate Symspsium, December 12 & 13, 2012 Hong Kong. 2012, 98.

Researcher : MANIO MM

List of Research Outputs

MANIO M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., Effects of manganese tetrakis (4-N-methylpyridyl) porphyrin (MnTMPyP) on dexmedetomidine-induced contractions in the aorta of normal and septic rats, Experimental Biology 2013, Boston April 20-24, 2013.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Dexmedetomidine-Induced Contractions in Aorta of Normal and Septic Rats, The Institute of Cardiovascualr Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP09.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on Dexmedetomidine Induced Contractions in the Aorta of Normal and Septic Rats, Annual Scientific Meeting in Anaesthesiology 2012 Hong Kong, 23-25 November 2012. 35.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on dexmedetomidine-induced Contractions in Isolated Rat Aortae , 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 215.

Researcher : Man GSK

List of Research Outputs

KONG W.C.B., Man G.S.K. and Leung S.W.S., Investigation On The Involvement Of Reactive Oxygen Species And Mitogen-Activated Protein Kinase In Endothelium-Dependent Relaxation In Spontaneously Hypertensive Rats, Dublin, Ireland , 6th European Workshop on Cannabinoid Research . 2013.

Researcher : Man RYK

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Man RYK
Department:	Pharmacology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	Protective effects of vitamin D on endothelial dysfunction in hypertension
Investigator(s):	Man RYK, Leung SWS, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010
Completion Date:	09/2012

Project Title:	Peroxisome Proliferator-Activated Receptors and Vascular Function
Investigator(s):	Man RYK, Leung SWS, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	Involvement of cyclooxygenase pathway in the vascular actions of estrogen
Investigator(s):	Man RYK, Leung SWS
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	EDHF 2012; Effect of isoflavones on the vascular actions of phosphodiesterase inhibitors
Investigator(s):	Man RYK
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Potential protective effects of L-citrulline supplementation against endothelial dysfunction: role of arginase
Investigator(s):	Man RYK, Leung SWS
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2013

List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, 46: 1123-1129.

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

MANIO M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., Effects of manganese tetrakis (4-N-methylpyridyl) porphyrin (MnTMPyP) on dexmedetomidine-induced contractions in the aorta of normal and septic rats, Experimental Biology 2013, Boston April 20-24, 2013.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Dexmedetomidine-Induced Contractions in Aorta of Normal and Septic Rats, The Institute of Cardiovascualr Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP09.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on Dexmedetomidine Induced Contractions in the Aorta of Normal and Septic Rats, Annual Scientific Meeting in Anaesthesiology 2012 Hong Kong, 23-25 November 2012. 35.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on dexmedetomidine-induced Contractions in Isolated Rat Aortae , 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 215.

QU C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha, European Journal of Pharmacology. 2012, 696: 101-110.

Researcher : Manio MM

List of Research Outputs

Researcher : Ng JKF

Project Title:	The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):	Ng JKF, Leung SWS
Department:	Anaesthesiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	ICCVA 2012/ NZ ASM New Zealand Anaesthesia Annual Scientific Meeting combined with the 13th International Congress of Cardiothoracic and Vascular Anesthesia; Aspirin does not potentiate hypothermia induced impairment of primary haemostasis in healthy volunteers
Investigator(s):	Ng JKF
Department:	Anaesthesiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2012

List of Research Outputs

MANIO M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., Effects of manganese tetrakis (4-N-methylpyridyl) porphyrin (MnTMPyP) on dexmedetomidine-induced contractions in the aorta of normal and septic rats, Experimental Biology 2013, Boston April 20-24, 2013.

Researcher : QU C

List of Research Outputs

QU C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha, European Journal of Pharmacology. 2012, 696: 101-110.

Researcher : Tang EHC

Project Title:	The role of EP4 in inflammation of adipose tissue
Investigator(s):	Tang EHC, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	08/2010
Completion Date:	08/2012

Project Title:	EP4 agonists alleviate inflammation in mouse models of atherosclerosis and obesity.
Investigator(s):	Tang EHC, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	EDHF2012 PROSTAGLANDIN E2-EP4 SIGNALING REDUCES INFLAMMATION IN MOUSE ADIPOSE TISSUE
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications.
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2012

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	CODHy Congress; EP4 receptor alleviates inflammation during diet-induced obesity
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Genetic ablation of prostaglandin E receptor 4 prevents diet-induced obesity, 14th Hong Kong Pharmacology Society Annual Scientific Meeting, Hong Kong, November 3, 2012, OP3. 2012.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-independent repressor activator protein 1 regulates NF-kB-dependent gene expression in macrophages,, 16th Annual scientific meeting of Institute of cardiovascular science and medicine, Hong Kong, November 17, 2012. CP8. . 2012.

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-Independent Repressor Activator Protein 1 Regulates NF-KB-Dependent Gene Expression in Macrophages, The Institute of Cardiovascular Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP08.

Researcher : Tang HC

Project Title:	The role of EP4 in inflammation of adipose tissue
Investigator(s):	Tang EHC, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	08/2010
Completion Date:	08/2012

Project Title:	EP4 agonists alleviate inflammation in mouse models of atherosclerosis and obesity.
Investigator(s):	Tang EHC, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	EDHF2012 PROSTAGLANDIN E2-EP4 SIGNALING REDUCES INFLAMMATION IN MOUSE ADIPOSE TISSUE
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications.
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2012

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	CODHy Congress; EP4 receptor alleviates inflammation during diet-induced obesity
Investigator(s):	Tang EHC
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

Researcher : Tom WM

Project Title:	VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning
Investigator(s):	Tom WM
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Tong HHY

List of Research Outputs

CHEN S., Tong H.H.Y. and Kwok P.C.L., Spray dried oleanolic acid powder for pulmonary delivery, Inhalation Asia 2013, The University of Hong Kong, Hong Kong SAR, 26-28 June 2013.

Researcher : Vanhoutte P.M.G.

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

List of Research Outputs

Researcher : Vanhoutte PMGR

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

List of Research Outputs

Alkharfy K.M., Al-Daghri N.M., Vanhoutte P.M.G.R., Krishnaswamy S. and Xu A., Serum Retinol-Binding Protein 4 as a Marker for Cardiovascular Disease in Women, PLOS ONE. 2012, 7: 1-8.

Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.

Barton M., Yanagisawa M., Vanhoutte P.M.G.R. and Masaki T., Endothelin XII, Life Sciences. 2012, 91: 449-451.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Genetic ablation of prostaglandin E receptor 4 prevents diet-induced obesity, 14th Hong Kong Pharmacology Society Annual Scientific Meeting, Hong Kong, November 3, 2012, OP3. 2012.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-independent repressor activator protein 1 regulates NF-kB-dependent gene expression in macrophages,, 16th Annual scientific meeting of Institute of cardiovascular science and medicine, Hong Kong, November 17, 2012. CP8. . 2012.

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Telomeric-Independent Repressor Activator Protein 1 Regulates NF-KB-Dependent Gene Expression in Macrophages, The Institute of Cardiovascular Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP08.

Chan K.Y.C., Liao S., Zhang Y., Lee Y.K.M., Xu A., Tse H.F. and Vanhoutte P.M.G.R., A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium, ACS Chem Neurosci. 2013, 4(1): 122-9.

Chan K.Y.C. and Vanhoutte P.M.G.R., Hypoxia, vascular smooth muscles and endothelium, Acta Pharmaceutica Sinca B. 2012, 1: 1-7.

Dong J.H., Wong S.L., Lau C.W., Lee H.Y., Ng C.F., Zhang L.H., Yao X.Q., Chen Z.Y., Vanhoutte P.M.G.R. and Huang Y., Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress, European Heart Journal. 2012, 33: 2980-2990.

Feletou M. and Vanhoutte P.M.G.R., Endothelium-Dependent Hyperpolarization: No Longer an F-Word!, J Cardiovasc Pharmacol. 2013, 61: 91-92.

Jong H.L., Mustafa M.R., Vanhoutte P.M.G.R., AbuBakar S. and Wong P.F., MicroRNA 299-3p modulates replicative senescence in endothelial cells, Physiol. Genomics. 2013, 45: 256-267.

Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4, Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, 33: 777-784.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing nadph oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol. 2013, 33: 777-784.

LIN H.Y.A., Li W.S.R., Ho Y.W., Leung G.P.H., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Differential ligand binding affinities of human estrogen receptor-α isoforms, PLOS One. 2013, 8: e63199.

Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

MANIO M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., Effects of manganese tetrakis (4-N-methylpyridyl) porphyrin (MnTMPyP) on dexmedetomidine-induced contractions in the aorta of normal and septic rats, Experimental Biology 2013, Boston April 20-24, 2013.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Dexmedetomidine-Induced Contractions in Aorta of Normal and Septic Rats, The Institute of Cardiovascualr Science and Medicine, Sixteenth Annual Scientific Meeting, Hong Kong, 17 November 2012. CP09.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on Dexmedetomidine Induced Contractions in the Aorta of Normal and Septic Rats, Annual Scientific Meeting in Anaesthesiology 2012 Hong Kong, 23-25 November 2012. 35.

Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of LPS on dexmedetomidine-induced Contractions in Isolated Rat Aortae , 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 215.

QU C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha, European Journal of Pharmacology. 2012, 696: 101-110.

Tripathy N., Lan Y., Lam J.K.W., Vanhoutte P.M.G.R. and Hahn Y.B., Comprehensive Study on the Toxicology of Surface-Coated ZnO Nanoparticles in Human Alveolar Adenocarcinoma (A549) Cells, Science of Advanced Materials. 2013, 5: 421-429.

Vanhoutte P.M.G.R., Airway epithelium-derived relaxing factor: myth, reality, or naivety?, Am J Physiol Cell Physiol. 2013, 304: C813-C820.

Vanhoutte P.M.G.R. and Gao Y.S., Beta blockers, nitric oxide, and cardiovascular disease, Current Opinion in Pharmacology. 2012, 14: 1-9.

Vanhoutte P.M.G.R., Obesite et fonction endotheliale, Elsevier Masson. 2013, 71: 42-50.

Vanhoutte P.M.G.R., One or Two, Does it Matter as Long as the Arterial Wall Is Coxygenated?, Hypertension. 2013, 62: 244-246.

Vanhoutte P.M.G.R., Serotonin: Beyond the Brain, ACS Chem. Neurosci.. 2013, 4: 26-27.

Wang T., MAO X., Li H., Qiao S., Xu A., Lei S., Liu Z., Ng J.K.F., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z., N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and P13K/Akt pathway via adiponectin and attenuated myocardial post-ischemic injury in Diabetes, Free Radic Biol Med. 2013, 5.

Wang T., MAO X., LI H., Qiao S., Xu A., Wang J., Lei S., LIU Z., Ng K., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol up-regulated the jak/stat3 and pi3k/akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes, Free Radic Biol Med. 2013, 63: 291-303.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

YAU K.H., Mak J.C.W., Leung S.W.S., Yang D. and Vanhoutte P.M.G.R., A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat, PLOS One. 2012, 7: e45340.

Yung L.M., Tian X.Y., Wong W.T., Leung F.P., Yung L.H., Chen Z.Y., Lau C.W., Vanhoutte P.M.G.R., Yao X.Q. and Huang Y., Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats, Eur J Nutr. 2012, 52: 1145-1155.

ZHAO Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of α1-adrenergic receptors causes thromboxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Experimental Biology 2013, Boston, MA, USA. 2013.

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Experimental Biology 2013, Boston MA, USA. 2013.

Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Endothelial Nitric Oxide Synthase-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat, J Pharmacol Exp Ther. 2013, 344: 15-22.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxation induced by mild hypothermia in the rat aorta, 17th Research Postgraduate Symposium, Hong Kong December 12 & 13, 2012. 192.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Fifth Scientific Meeting of Asian Society for Vascular Biology, Xian China 27-29 October 2012. 30.

Researcher : Wang Y

Project Title:	Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Oxidative peptide signatures as potential diagnostic biomarkers for obesity-related diabetes and cardiovascular diseases
Investigator(s):	Wang Y, Siu AFM
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	03/2012

Project Title:	SIRT1 in cardiometabolic syndrome: Does liver play a role?
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	The Tenth Anniversary EDHF Meeting - EDHF2012 Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Aging and Diseases of Aging; The promise of SIRT1, a longevity regulator, in cardiometabolic syndrome
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	HERC2 in regulating endothelial senescence and vascular homeostasis
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.

Bai B. and Wang Y., Methods to investigate the role of SIRT1 in endothelial senescence, Cell Senescence – methods and protocols . Methods in Molecular Biology, 2013, 965: 327-39.

Chen J., Xu A., Liu J., Lam K.S.L. and Wang Y., Adipose-derived Stromal Cells Derived from Adiponectin Deficient Mice Promote the Development of Metaplastic Mammary Tumors, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 67.

Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma Lipocalin-2 Concentration is Related to Blood Pressure and is Increased in Hypertension, 6th European Congress of Pharmacology, Jul 2012, Granada. 2012.

Fan P., Berger T., Xu A., Mak T.W. and Wang Y., Lipocalin-2 Acts as a Stromal Factor to Promote Mammary Carcinogenesis by Activating Phospholipase A2 in Breast Cancer Cells, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 164.

Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C.Y. and Jin L., Porphyromonas gingivalis LPS regulates MnSOD in HGFs through TLR4-NF-kB pathway, Journal of Dental Research. 2012, 91 (Spec Iss C): 169737 (SEA Division).

Herath Mudiyanselage T.D.K.H., Darveau R.P., Seneviratne C.J., Wang C.Y., Wang Y. and Jin L., Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-kB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts, PLoS One. 2013, 8: e58496.

Herath Mudiyanselage T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C.Y. and Jin L., The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts, BMC Microbiology. 2013, 13: 73.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4, Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, 33: 777-784.

LIANG C., LIU T.C., Wang Y., Xu A. and Vanhoutte P.M.G.R., Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing nadph oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol. 2013, 33: 777-784.

Lam K.Y.J., Wang Y., Shiu S.W.M., Wong Y. and Tan K.C.B., Soluble receptor for advanced glycation end-products in Chinese Type 1 diabetic patients., The 9th International Diabetes Federation Western pacific Region Congress, Kyoto, Japan. 2012.

Leung T.Y., Leung K.M.Y., PARK T.J. and Wang Y., Isoform-specific responses of metallothioneins in the marine pollution biomonitor Perna viridis corresponding to two different modes of toxic action, an oral presentation at The SETAC Asia Pacific 2012 Annual Meeting, held during 24-27 September, 2012 at Kumamoto, Japan. 2012.

Li F.Y.L., Lam K.S.L., Tse H.F., Chen C., Wang Y., Vanhoutte P.M.G.R. and Xu A., Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes-Induced Impairment in Vascular Function and Re-Endothelialization via Induction of Heme Oxygenase-1 in Mice, Circulation. 2012, 126: 1267-77.

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Lin Z., Tian H., Lam K.S.L., Lin S., Hoo R.L.C., Konishi M., Itoh N., Wang Y., Bomstein S.R., Xu A. and Li X., Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice, Cell Metabl . 2013, 17: 779-789.

Samaranayake Y.H., Cheung B.P.K., Wang Y., Yau J.Y.Y., Yeung S.K.W. and Samaranayake L.P., Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production., Journal of Medical Microbiology. 2013, 62(Pt 2): 303-318.

Tan K.C.B., TSUN G.S., Shiu S.W.M., Wang Y., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1 expression in monocytes is associated with HDL-carboxymethyllysine in type 2 diabetes., 48th european Association for the study of Diabetes Annual Meeting, Berlin, Germany.. 2012.

Wang Y., Lam K.S.L. and Xu A., Adiponectin and chronic liver diseases: an update, Adiponectin: Production, Regulation and Roles in Disease. Nova Science, 2012.

Wang Y., Anti-Vascular Aging Effects of SIRT1, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 32.

Wang Y., Anti-vascular aging effects of SIRT1., Eighth International Symposium on Healthy Aging "How to Age with Finesse". 2013.

Wang Y., Cardiovascular Pharmacology . 2013.

Wang Y., International Journal of Pharmacological Sciences. 2013.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Wang Y., Targeting SIRT1 in adipose tissue as an effective approach for combating metabolic ageing. , 2013 Hong Kong Symposium Obesity and Diabetes. 2013.

Woo Y.C., Xu A., Wang Y. and Lam K.S.L., Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives, Clin Endocrinol (Oxf). 2012, 78: 489-496.

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Xu G., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, Journal of Biological Chemistry. 2012, 287: 4808-17.

Yang B., Ye D. and Wang Y., Caspase-3 as a therapeutic target for heart failure. , Expert Opinion on Therapeutic Targets. . 2013, 17: 255-63.

Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.Y., Li X. and Xu A., Toll-like receptor-4 mediated obesity-induced nonalcoholic steatohepatitis through activation on X-box binding protein-1 in mice, Gut. 2012, 61(7): 1058-67.

Researcher : Wang Y

List of Research Outputs

Bai B. and Wang Y., Methods to investigate the role of SIRT1 in endothelial senescence, Cell Senescence – methods and protocols . Methods in Molecular Biology, 2013, 965: 327-39.

Liang Y., Bai B., Li J., Vanhoutte P.M.G.R. and Wang Y., LKB1/AMPK Signaling in Vascular Homestasis: Friend or Foe, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.13.

Wang Y., Lam K.S.L. and Xu A., Adiponectin and chronic liver diseases: an update, Adiponectin: Production, Regulation and Roles in Disease. Nova Science, 2012.

Wang Y., Anti-Vascular Aging Effects of SIRT1, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 32.

Wang Y., Anti-vascular aging effects of SIRT1., Eighth International Symposium on Healthy Aging "How to Age with Finesse". 2013.

Wang Y., Cardiovascular Pharmacology . 2013.

Wang Y., International Journal of Pharmacological Sciences. 2013.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Wang Y., Targeting SIRT1 in adipose tissue as an effective approach for combating metabolic ageing. , 2013 Hong Kong Symposium Obesity and Diabetes. 2013.

Woo Y.C., Xu A., Wang Y. and Lam K.S.L., Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives, Clin Endocrinol (Oxf). 2012, 78: 489-496.

Xu G., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, Journal of Biological Chemistry. 2012, 287: 4808-17.

Yang B., Ye D. and Wang Y., Caspase-3 as a therapeutic target for heart failure. , Expert Opinion on Therapeutic Targets. . 2013, 17: 255-63.

Researcher : Wang Y.

Project Title:	Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Oxidative peptide signatures as potential diagnostic biomarkers for obesity-related diabetes and cardiovascular diseases
Investigator(s):	Wang Y, Siu AFM
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	03/2012

Project Title:	SIRT1 in cardiometabolic syndrome: Does liver play a role?
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	The Tenth Anniversary EDHF Meeting - EDHF2012 Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Aging and Diseases of Aging; The promise of SIRT1, a longevity regulator, in cardiometabolic syndrome
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2012

Project Title:	HERC2 in regulating endothelial senescence and vascular homeostasis
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Researcher : Wong ICK

Project Title:	Oral Transmucosal Drug Delivery System for Paediatric and Emergency Medications.
Investigator(s):	Wong ICK, Lam JKW, Kwok PCL
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012

Project Title:	EU Regulatory Workshop on Medication Errors, ; Medication errors in special populations or circumstances: Paediatric patients and their caregivers
Investigator(s):	Wong ICK
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2013

List of Research Outputs

Almandil N.B., Liu Y., Murray M.L., Besag F.M., Aitchison K.J. and Wong I.C.K., weight gain and other metabolic adverse effects associated with atypical antipsychotic treatment of children and adolescents: a systematic review and meta-analysis, Paediatr Drugs. 2013, 15(2): 139-50.

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Huynh C., Wong I.C.K., Tomlin S., Terry D., Sinclair A., Wilson K. and Jani Y., Medication discrepancies at transitions in pediatrics: a review of the literature, Paediatr Drugs. 2013, 15(3): 203-15.

Huynh C., Jani Y., Wong I.C.K., Dewchand B. and Tomlin S., What is the current practice of medicines reconciliation in children nationally in the UK?, Int J Pharm Pract. 2013, 21(1): 62-5.

Lam M.P.S., Cheung B.M.Y. and Wong I.C.K., Evalution of Beers and Stopp/Start Criteria for Prescribing Appropriateness Among Hong Kong Elderly, Eight International Symposium on Healthy Aging, 9-10 March 2013, Hong Kong. 2013, 60.

Leung A.Y.M., XIA N., Wong I.C.K., Chen J.Y., Lou V.W. and Chan K.M.K., The undergraduate students' knowledge of Alzheimer's Disease (AD): a cross-sectional study, The 19th Annual Congress of Gerontology, Hong Kong Association of Gerontology - Promoting Choices and Frontiers in Elderly Care. Hong Kong, 2012.

Matheson L., Asherson P., Wong I.C.K., Hodgkins P., Setyawan J., Sasane R. and Clifford S., Adult ADHD patient experiences of impairment, service provision and clinical management in England: a qualitative study , BMC Health Serv Res.. 2013, 13: 184.

McCarthy S., Wilton L., Murray M., Hodgkins P., Asherson P. and Wong I.C.K., Management of adult attention deficit hyperactivity disorder in UK primary care: a survey of general practitioners, Health Qual Life Qutcomes. 2013, 11:22.

McCarthy S., Wilton L., Murray M.L., Hodgkins P., Asherson P. and Wong I.C.K., Persistence of pharmacological treatment into adulthood, in UK primary care, for ADHD patients who started treatment in childhood or adolescence, BMC Psychiatry. 2012, 12:219.

Murray M.L., Insuk S., Banaschewski T., Neubert A.C., McCarthy S., Buitelaar J.K., Coghill D., Dittmann R.W., Konrad K., Panei P., Rosenthal E., Sonuga-Barke E.J. and Wong I.C.K., An inventory of European data sources for the long-term safety evaluation of methylphenidate, Eur Child Adolesc Psychiatry. 2013.

Murray M.L., Hsia Y., Glaser K., Simonoff E., Murphy D.G., Asherson P.J., Eklund H. and Wong I.C.K., Pharmacological treatments prescribed to people with autism spectrum disorder (ASD) in primary health care. , Psychopharmacology (Berl). . 2013.

Oehme A.K., Rashed A.N., Hefele B., Wong I.C.K., Rascher W. and Neubert A., Adverse drug reactions in hospitalized children in Germany are decreasing: results of a nine year cohort-based comparison, PLoS One. 2012, 7(9): e44349.

Rashed A.N., Neubert A., Alharmdan H., Tomlin S., Alazmi A., Alshaikh A., Wilton L. and Wong I.C.K., Drug-related problems found in children attending an emergency department in Saudi Arabia and in the United Kingdom, Int J Clin Pharm. 2013, 35(3): 327-31.

Sonuga-Barke E.J., Brandeis D., Cortese S., Daley D., Ferrin M., Holtmann M., Stevenson J., Danckaerts M., van der Oord S., Dopfner M., Dittmann R.W., Simonoff E., Zuddas A., Banaschewski T., Buitelaar J., Coghill D., Hollis C., Konofal E., Lecendreux M., Wong I.C.K., Sergeant J. and European ADHD Guidelines G., Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments, Am J Psychiatry. 2013, 170(3): 275-89.

Star K., Lessa N., Almandil N.B., Wilton L., Curran S., Edwards I.R. and Wong I.C.K., Rhabdomyolysis reported for children and adolescents treated with antipsychotic medicines: a case series analysis, J Child Adolesc Psychopharmacol. 2012, 22(6): 440-51.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., Drug wastage among the elderly living in old aged homes in Hong Kong, Hong Kong Pharm J. 2013, 20: 16-18.

Wong A.Y.S., Chan W.L.P., Chan W.Y.E., Cheng M. and Wong I.C.K., The pharmaceutical services to the elderly in the old aged homes in Hong Kong: a scope exercise. , Hong Kong Pharm J. 2013, 20: 11-15.

Wong I.C.K., Experience of taking part as an Asian member of the European Framework 7th Research Programme, Global Education Dialogues – The Asia Series, September 28, 2012, Novotel Century Hong Kong Hotel, Wan Chai, Hong Kong . 2012.

Wong I.C.K., Experience of taking part as an Asian member of the European Framework 7th Research Programme, Global Education Dialogues: The Asia Series Conference, British Council. Sept 27-28, 2012 Hong Kong.. 2012.

Wong I.C.K., Paediatric Medication Safety - an International Perspective, Department of Paediatric and Adolescent Medicine, University Hospital Eriangen, July 17, 2012, Erlangen. 2012.

Wong I.C.K., The effectiveness of Pneumococcal Conjugate Vaccine: An UK experience, Pneumococcal Conjugate Vaccine Symposium, Hong Kong Medical Association and Hong Kong Society for Infectious Diseases. Oct 8, 2012 Hong Kong.. 2012.

XIA N., Leung A.Y.M., Wong I.C.K., Chen J.Y., Lou V.W. and Chan K.M.K., Understanding undergraduate students' knowledge and belief about Alzheimer's Disease: A cross-sectional study, The 17th Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong,. 2012, 109.

XU Y., Lam J.K.W., Wong I.C.K. and lessa N., Practical Therapeutics: benefits of buccal midazolam in paediatric patients benefits of buccal midazolam in paediatric patients, Hospital Pharmacy Europe. 2012, 65: 55-8.

Researcher : Wong YS

List of Research Outputs

Chan W.Y.E., He Y., Chui S.L.C., Wong Y.S., Lau C.Y. and Wong I.C.K., Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs, Obes Rev. 2013, 14(5): 383-92.

Researcher : Worsley AJ

Project Title:	The quantification and elucidation of alkaloid content of Strychnos angustiflora Benth Seeds and pericarp
Investigator(s):	Worsley AJ, Dufay S
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Watjana W. .W., Bello N., Baqir W. and Worsley A.J., Prevalence and perceived outcomes of complementary and alternative medicine use in hospitalized British Patients, Archives of Pharmacy Practice. Archive Global Professionals, 2012, 3: 265-273.

Researcher : XU C

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, 17th Research Postgraduate Symposium, Hong Kong, 12-13 December 2012. 2.01.

Li J., Xu C., Bai B., Man R.Y.K., Vanhoutte P.M.G.R. and Wang Y., Does eNOS play a major role in SIRT1-mediated vasodilatation?, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 94.

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

XU C., FAN P., CAI Y., Huang B., Law K.M., Liu L., TUNG C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, Am J Transl Res. 2013, 5: 412-426.

Xu C., Bai B., Fan P., CAI Y., Huang B., Law K.M., Liu L., Xu A., Tung C.L., Li X.C., Siu A.F.M., Che C.M., Vanhoutte P.M.G.R. and Wang Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice, American Journal of Translational Research. e-Century Publishing, 2013, 5: 412-426.

Researcher : XU Y

List of Research Outputs

XU Y., Lam J.K.W., Wong I.C.K. and lessa N., Practical Therapeutics: benefits of buccal midazolam in paediatric patients benefits of buccal midazolam in paediatric patients, Hospital Pharmacy Europe. 2012, 65: 55-8.

YE Y., Xu Y., Liang W., Leung G.P.H., Cheung K.H., Zheng C., Chen F. and Lam J.K.W., DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells, Journal of Drug Targeting. 2013, 21: 474-486.

Researcher : Xu C

List of Research Outputs

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Researcher : Xu C

List of Research Outputs

Wang Y., Xu C., LIANG Y. and Vanhoutte P.M.G.R., SIRT1 in metabolic syndrome: where to target matters, Pharmacology & Therapeutics. 2012, 136: 305-18.

Researcher : Xu Y

List of Research Outputs

Researcher : Yang B

List of Research Outputs

Xu G., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, Journal of Biological Chemistry. 2012, 287: 4808-17.

Yang B., Ye D. and Wang Y., Caspase-3 as a therapeutic target for heart failure. , Expert Opinion on Therapeutic Targets. . 2013, 17: 255-63.

Researcher : Ye D

Project Title:	Role of lipocalin-2 in nonalcoholic fatty liver disease
Investigator(s):	Ye D, Wang Y
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Yang B., Ye D. and Wang Y., Caspase-3 as a therapeutic target for heart failure. , Expert Opinion on Therapeutic Targets. . 2013, 17: 255-63.

Researcher : ZHAO Y

List of Research Outputs

ZHAO Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of α1-adrenergic receptors causes thromboxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Experimental Biology 2013, Boston, MA, USA. 2013.

Zhao Y., Vanhoutte P.M.G.R. and Leung S.W.S., Endothelial Nitric Oxide Synthase-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat, J Pharmacol Exp Ther. 2013, 344: 15-22.

Researcher : ZOU Q

List of Research Outputs

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Experimental Biology 2013, Boston MA, USA. 2013.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxation induced by mild hypothermia in the rat aorta, 17th Research Postgraduate Symposium, Hong Kong December 12 & 13, 2012. 192.

Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Endogenous acetylcholine contributes to endothelium-dependent relaxations induced by mild hypothermia in the SHR aorta, Fifth Scientific Meeting of Asian Society for Vascular Biology, Xian China 27-29 October 2012. 30.

Researcher : Zhao Y

List of Research Outputs

Researcher : Zou Q

List of Research Outputs

-- End of Listing --