Dept of Anatomy

DEPT OF ANATOMY

Researcher : Arokiaraj AWR

List of Research Outputs

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural Basis for Role of Ring Finger Protein RNF168 RING Domain, Keystone Symposia - Genomic Instability and DNA Repair. 2013.

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural basis for role of Ringer Finger Protein RNF168 Ring domain, Cell Cycle. 2013, 12(2): 312-21.

Researcher : CHEN J

List of Research Outputs

Chen J., Feng W. and Huen M.S.Y., DYRK1A is an RNF169-interacting partner involved in DNA damage signaling, International Symposium on DNA Damage Response & Human Diseases - Beijing 2012 (isDDRHD-Beijing 2012). 2012.

Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., Ring Finger Protein RNF169 Antagonises The Ubiquitin-dependent Signaling Cascade At Sites Of Dna Damage, Journal of Biological Chemistry. 2012, In Press.

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural Basis for Role of Ring Finger Protein RNF168 RING Domain, Keystone Symposia - Genomic Instability and DNA Repair. 2013.

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural basis for role of Ringer Finger Protein RNF168 Ring domain, Cell Cycle. 2013, 12(2): 312-21.

Researcher : CHEN Y

List of Research Outputs

CHEN Y., Tai A.C.P., Kai A.K.L., Tam S., Lam K.S.L., Chung S.S.M., Xu A. and Chung S.K., Exchange protein directly activated by cAMP plays an important role in b3-adrenergic induction of UCP1 in WAT and thermogenesis via regulating lipolysis, American Diabetes Association 73rd Scientific Sessions, June 21-25, 2013, Chicago, Illinois, U. S. A.. 2013, 62 Suppl. 1A.

Chen Y. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue., Anatomy Postgraduate Symposium. 2012.

Researcher : Chan CWY

Project Title:	Pluripotent stem cells as source of dendritic cell-based immune therapy to induce tolerance.
Investigator(s):	Chan CWY, Li RA
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Linking autophagy and inflammation in human embryonic stem cell-derived cardiomyocytes
Investigator(s):	Chan CWY, Li RA
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

Chan C.W.Y., Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions., PloS One. 2012, 7(11).

Chow C.H., Cheung A.M.S., Li R.A., Chan C.W.Y., So E.C.W. and Leung A.Y.H., The use of human induced pluripotent stem cells (hiPSC) for modeling blood disorders, Drug Discovery Today: Disease Models. 2012.

Tso H.W., He R.J. and Chan C.W.Y., Engineering of the immune system for human ESC- and iPSC-derived grafts, Drug Discovery Today: Disease Models. 2012, 9: e171-178.

Researcher : Chan MCW

Project Title:	Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo
Investigator(s):	Chan MCW, Peiris JSM, Chan WY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2009

Project Title:	Effect of allogeneic human mesenchymal stem cells on alveolar fluid clearance and protein permeability in human alveolar epithelial cells injured by influenza H5N1 virus infection
Investigator(s):	Chan MCW, Nicholls JM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract
Investigator(s):	Chan MCW, Chan WY, Nicholls JM, Mak JCW
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011

Project Title:	Tropism and innate host responses in primary human cardiac myocytes infected with influenza H5N1 and H1N1pdm virus
Investigator(s):	Chan MCW
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Role of indirubin-3’-oxime as an antiviral and immunomodulatory agent in the treatment of severe human influenza virus infection
Investigator(s):	Chan MCW
Department:	School of Public Health
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

Project Title:	Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells on Acute Lung Injury Caused by Severe Influenza H5N1 Virus Infection
Investigator(s):	Chan MCW, Peiris JSM, Guan Y, Chan GCF, Chan WY
Department:	School of Public Health
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	05/2012

Project Title:	A comparative study of influenza A viruses with differential interferon induction with respect to their potential to confer increased susceptibility to secondary bacterial infections
Investigator(s):	Chan MCW
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	A mouse model to study the beneficial effect of human mesenchymal stem cells on acute lung injury induced by influenza H5N1 virus infection
Investigator(s):	Chan MCW
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2013

List of Research Outputs

Chan W.Y., Leung C.Y.H., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses., PLoS One. 2012, 7(11): e51057.

Researcher : Chan TK

Project Title:	Introduction of presumed consent and implementation of other measures to promote cadeveric kidney donation in Hong Kong: public attitudes and review of legal and ethical principles – implications of public health policy
Investigator(s):	Chan TK, Cowling BJ
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	The impact of educational intervention on registration as an organ donor: a pilot study
Investigator(s):	Chan TK, Ho MCT
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

Chan T.K., Cowling J. and Tipoe G.L., A public opinion survey: is presumed consent the answer to kidney shortage in Hong Kong?, BMJ Open. 2012, 3:e002013: 1-6.

Chan T.K., Private Practice can be good for patients, In: Fiona Godlee, British Medical Journal. 2012.

Chan T.K. and Tipoe G.L., Should we continue treatment for M? The benefits of living, Journal of Medical Ethics. 2013, 0: 1-3.

Chan T.K. and Tipoe G.L., The best interests of persistently vegetative patients: to die rather that to live?, Journal of Medical Ethics. 2013, 0: 1-3 doi:10.1136.

Researcher : Chang R.C.C.

Project Title:	Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	03/2008

Project Title:	Elucidating the pathophysiological significance of endoplasmic reticulum aggregation in neurons stressed by ?amyloid peptide and in Alzheimers disease'
Investigator(s):	Chang RCC, Wu W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Impact of tau protein on corticosterone-induced depression to synergize neurodegeneration in Alzheimer’s disease
Investigator(s):	Chang RCC, Ho YS
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Alzheimer's Association International Conference 2012; Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012

Project Title:	Elucidating the roles of PKR in the brain during systemic inflammation
Investigator(s):	Chang RCC, Ho YS, Chiu K, Cheung KH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

Researcher : Chang RCC

Project Title:	Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	03/2008

Project Title:	Elucidating the pathophysiological significance of endoplasmic reticulum aggregation in neurons stressed by ?amyloid peptide and in Alzheimers disease'
Investigator(s):	Chang RCC, Wu W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Impact of tau protein on corticosterone-induced depression to synergize neurodegeneration in Alzheimer’s disease
Investigator(s):	Chang RCC, Ho YS
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Alzheimer's Association International Conference 2012; Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide
Investigator(s):	Chang RCC
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012

Project Title:	Elucidating the roles of PKR in the brain during systemic inflammation
Investigator(s):	Chang RCC, Ho YS, Chiu K, Cheung KH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Chang R.C.C., Biological mechanisms of risk factors leading to Alzheimer’s disease and dementia, Keynote Lecture, The 7th Annual Scientific Meeting, Hong Kong Society of Biological Psychiatry, Hong Kong. 2013.

Chang R.C.C., Characterizing the morphological changes and dynamic of mitochondria in neurons after exposure to ß-amyloid peptide, Keynote Lecture, The 11th International Conference of Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Chang R.C.C., Hung C.H.L., Zhang Q. and Ho Y.S., Characterizing the morphological changes and dynamic of mitochondria in neurons after exposure to ß-amyloid peptide., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease. Florence, Italy. 2013.

Chang R.C.C., Hung H.L., Wuwongse S., Zhang Q. and Ho Y.S., Early dynamic changes of mitochondrial morphology in hippocampal neurons in response to beta-amyloid, Society for Neuroscience. 2012, 220.13.

Chang R.C.C., Editorial Board Member, Advances in Alzheimer's Disease. 2012.

Chang R.C.C., Editorial Board Member, Asian Journal of Neuroscience. 2013.

Chang R.C.C., Editorial Board member, Dataset Paper in Medicine (Ophthalmology). 2013.

Chang R.C.C., Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide, Alzheimer Association International Conference 2012, Vancouver, Canada. 2012.

Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide, Alzheimer's & Dementia. 2012, 8 (4) Supplment: 252-253.

Chang R.C.C., Herbal medicine preventing aging-associated neurodegenerative disease, The First International Symposium of “The Science of Aging and Age Control”, Hong Kong Science Park, Hong Kong. 2012.

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Chang R.C.C., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium, Monash University Sunway Campus, Malaysia. 2012.

Chang R.C.C., New insights from investigating pathological mechanisms of Alzheimer’s disease, School of Chinese Medicinal Science, University of Macau, Macau. 2013.

Chang R.C.C., Organizing Committee Member, The 8th International Symposium on Healthy Aging: How to age with finesse?. 2012.

Chang R.C.C., Scientific Advisory Board Committee member, The 12th International Conference on Alzheimer's and Parkinson's Diseases, 2015, Nice, FRANCE. 2013.

Chang R.C.C., Scientific Committee Member, Asian Pacific Region of Alzheimer's Disease International Conference, 2013, Hong Kong and Macau. 2012.

Chang R.C.C., Scientific Review Committee 2013, Alzheimer Association, USA. 2013.

Chang R.C.C., Section Chief Editor, Journal of Neuroimmune Pharmacology. 2012.

Chang R.C.C., Session Chairman, Hong Kong International Integrative Medicine Conference on Chinese Medicine in Geriatrics. 2012.

Chang R.C.C., Session Chairman, The 11th International Conference of Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Chang R.C.C., Vice Chairman of Panel for Session of "Polychemical activities and mechanism study II (Metabolic, Neural Diseases and Aging Process), The 11th Meeting of Consortium for Globalization of Chinese Medicine, 2012, Macau. 2012.

Chao J., Leung Y., Wang M. and Chang R.C.C., Nutraceuticals and their preventive or potential therapeutic value for Parkinson's disease, Nutrition Reviews. 2012, 70: 373-386.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Chiu K., So K.F. and Chang R.C.C., Progressive neurodegeneration of retina in Alzheimer’s disease: Are beta-amyloid peptide and tau new pathological factors in glaucoma?, In: Shimon Rumelt, Glaucoma - Basic and Clinical Aspects. InTech Open Assess Publisher, 2012, 157-177.

Feng Q., Chang R.C.C., Chung S.K. and So K.F., Investigation of Iba1+/NG2++cells in the adult mouse retina after ischemia-reperfusion injury with or without Lycium Barbarum polysaccharide treatment, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 182 No. 2.08.

Ho W.L., Leung Y., Tsang A.W., So K.F. and Chang R.C.C., Review: Tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain?, Molecular Vision 2012. 2012, 18: 2700 - 2710.

Ho W.L., Leung Y., Tsang A.W.-.T., So K.F., Chiu K. and Chang R.C.C., Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?, Molecular Vision. 2012, 18: 2700-2710.

Ho Y.S., Hung C.H.L. and Chang R.C.C., Green tea and neurodegeneration in Alzheimer's disease, In: Victor R. Preedy, Tea in Health and Disease Prevention. Elsevier Publisher, 2013, 691-704.

Ho Y.S., Chao J. and Chang R.C.C., Oxyresveratrol, an active ingredient from Mulberry fruits (Morus alba L.), reduced alpha synuclein aggregation in an in vitro model of Parkinson's disease, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 271.

Huang C., Ho Y.S., Wong G.T.C., Irwin M.G. and Chang R.C.C., The Effects of Intravenous Propofol, Dexmedetomdine, Ketamine and Isoflurance on Tau Phosphorylation in neuronal cell culture and in vivo, The International Anesthesia Research Society 2013 Annual Meeting. 2013.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

Mi X.S., Zhong J.X., Chang R.C.C. and So K.F., Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma, Journal of Integrative Medicine. 2013, 11(4): 233-240.

Poon C.H., Ho Y.S., Chiu K. and Chang R.C.C., Cytokines: how important are they in mediating sickness?, Neuroscience and Biobehavioral Review. 2013, 37: 1-10.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

So K.F. and Chang R.C.C., Molecular mechanism of neuroprotection in neurodegenerative diseases using Gouqizi (Wolfberry), The 1st International Chinese Symposium on Free Radical Research, the 5th Symposium for three districts of Cross-straits on Free Radical Research & the 8th National Symposium on free Radical Research, August 7-9, 2012, China. 2012.

Tsang A.W.-.T., Wong T.H.G., Hung C.H.L., Cheng S.Y., Law A.C.K., Ho Y.S. and Chang R.C.C., ß-Amyloid and corticosterone-induced changes to tau protein in primary cultures of hippocampal neurons., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Wong T.H.G., Chang R.C.C. and Law A.C.K., A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression, Ageing Research Review. 2013, 12: 67-75.

Wong T.H.G., Wuwongse S., Hung H.L., Law A.C.K. and Chang R.C.C., Degeneration of microtubules in cultured hippocampal neurons stressed by beta-amyloid peptide and corticosterone, Alzheimer's Association International Conference 2012.

Wong T.H.G., Hung C.H.L., Law A.C.K. and Chang R.C.C., Morphological and dynamic change in microtubules of primary cultured hippocampal neurons stressed by ß-amyloid peptide and corticosterone., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

YANG D., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum extracts preserve retinal function and reduce neuronal damage in a mouse model of transient retinal ischemia, ARVO 2013 Annual Meeting. 2013.

YANG D., Yeung C.M., Li S.Y., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum polysaccharides protect brain from cerebral edema and blood-brain barrier disruption after ischemia/reperfusion injury, Eighth International Symposium on Healthy Aging: “How to Age with Finesse”. 2013.

ZHANG L., Chang R.C.C., Chu L.W. and Mak H.K.F., Current neuroimaging techniques in Alzheimer's disease and applications of animal models. American Journal of Nuclear Medicine and Molecular Imaging., 2012, 2(3): 386-404.

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Zhang Y.K., Wang J., Liu L., Chang R.C.C., So K.F. and Ju G., The effect of Lycium Barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats, BMC Complementary and Alternative Medicine. 2013.

Researcher : Chao J

List of Research Outputs

Chao J., Leung Y., Wang M. and Chang R.C.C., Nutraceuticals and their preventive or potential therapeutic value for Parkinson's disease, Nutrition Reviews. 2012, 70: 373-386.

Ho Y.S., Chao J. and Chang R.C.C., Oxyresveratrol, an active ingredient from Mulberry fruits (Morus alba L.), reduced alpha synuclein aggregation in an in vitro model of Parkinson's disease, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 271.

Researcher : Chau RMW

Project Title:	HUGO's Seventh International Human Genome Meeting, HGM2002 The Possible Mechanism of Action for Quinacrine Interacting the Scrapie Protein in Prion Disease
Investigator(s):	Chau RMW
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2002

Researcher : Chen AYS

Project Title:	Study of the role of polyol pathway activation the impaired nerve regeneration in diabetes
Investigator(s):	Chen AYS, Chung SK
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008

List of Research Outputs

Hung K.L., CHEN S.M.Y., TAI W.L., Chen A.Y.S., Chung S.K. and Cheung C.W., Over expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection, Life Sciences. . Elsevier Ltd, 2012, 91(13-14): 618-622.

Researcher : Chen J

List of Research Outputs

Researcher : Chen Y

List of Research Outputs

Researcher : Cheng SY

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Tsang A.W.-.T., Wong T.H.G., Hung C.H.L., Cheng S.Y., Law A.C.K., Ho Y.S. and Chang R.C.C., ß-Amyloid and corticosterone-induced changes to tau protein in primary cultures of hippocampal neurons., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Researcher : Cheung A

Project Title:	Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	An integrated approach to identify genes associated with esophageal cancer progression
Investigator(s):	Cheung A, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	22nd Biennial EACR Congress Id1-induced IGF2 promotes tumor angiogenesis by paracrine activation of stromal fibroblasts
Investigator(s):	Cheung A
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

Project Title:	MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy
Investigator(s):	Cheung A, Chan KW, Law SYK, Tsao GSW, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

Chen H., Liao S., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands, Free Radical Biology and Medicine. 2012, 53: 885-892.

Cheung A., Li B., Tsao G.S.W. and Chan K.W., Id1-induced IGF2 Promotes Tumor Angiogenesis by Paracrine Activation of Stromal Fibroblasts, In: Proceedings of the Meeting of the 22nd Biennial Congress of the European Association for Cancer Research; 2012 July 7-10; Barcelona, Spain. (EACR). 2012, 48 Supplement 5: S95.

Deng W., Tsao G.S.W., Guan X. and Cheung A., Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells., PLoS ONE. 2012, 7(10): e48576.

Han L., Li B., Tsao G.S.W. and Cheung A., Identification of microRNAs that target Id-1 in esophageal cancer, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013, Washington, U. S. A.. 2013, Abstract No. 1959.

Han L., Li B., Tsao G.S.W. and Cheung A., MicroRNAs Targeting Id-1 Exhibit Tumor Suppressive Effects in Esophageal Cancer, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBX031 functions as an oncoprotein by suppressing a apoptosis via regulation of MAPK pathway in esophageal squamous cell carcioma cell lines, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013 Washington, U. S. A.. 2013, Abstract No. 4305.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBXO31 Suppresses Apoptosis of Esophageal Cancer Cells via Regulation of MAPK Pathway, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Tsao G.S.W., Tsang C.M., Yip Y.L., Deng W., Cheung A. and Lo K.W., Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection., American Association of Cancer Research. 2013.

ZHU D., Yip Y.L., Deng W., Tsang C.M., Cheung A. and Tsao G.S.W., The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells, American Association of Cancer Research. 2013.

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Cheung A.

Project Title:	Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	An integrated approach to identify genes associated with esophageal cancer progression
Investigator(s):	Cheung A, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	22nd Biennial EACR Congress Id1-induced IGF2 promotes tumor angiogenesis by paracrine activation of stromal fibroblasts
Investigator(s):	Cheung A
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

Project Title:	MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy
Investigator(s):	Cheung A, Chan KW, Law SYK, Tsao GSW, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

Researcher : Cheung ALM

Project Title:	Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	An integrated approach to identify genes associated with esophageal cancer progression
Investigator(s):	Cheung A, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	22nd Biennial EACR Congress Id1-induced IGF2 promotes tumor angiogenesis by paracrine activation of stromal fibroblasts
Investigator(s):	Cheung A
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

Project Title:	MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy
Investigator(s):	Cheung A, Chan KW, Law SYK, Tsao GSW, Li B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

List of Research Outputs

Researcher : Cheung MPL

List of Research Outputs

Chen H., Liao S., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands, Free Radical Biology and Medicine. 2012, 53: 885-892.

Researcher : Ching Y.P.

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2013

Project Title:	Regulation of p53 by PAK4 in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER; Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2013

Project Title:	Regulation of p53 by PAK4 in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER; Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Lai W.L., Hung W.Y. and Ching Y.P., Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer, In: Hepatology International, 23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER. 2013, 7 Supplement 1: Abstract No.628.

Leung W.H., Ching Y.P. and So K.F., The potential role of fetal bovine serum (FBS) as positive control for studying neural stem cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12 & 13, 2012, Hong Kong. 2012, No. 2.15.

Mak W.Y.G., Lai W.L., Zhou Y., Li M., Ng I.O.L. and Ching Y.P., CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells, PLOS ONE. 2012, 7(7), pp: e42210.

Tang V.H.M., Gao W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Hiroshi T. and Jin D., LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription, Retrovirology. 2013, 10: 40.

Tang V.H.M., GAO W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H.I.R.O.S.H.I. and Jin D., Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases, 16th International Conference on Human Retrovirology HTLV and Related Viruses. 2013.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Tipoe. Garlic-derived S-allylmercaptocysteine is a novel hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2013, 52: 179-191.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Researcher : Chiu K

Project Title:	Significance of amyloid precursor protein processing and amyloid beta deposition in the retinal neurodegeneration: do ER-stress signaling or mitochondrial stress signaling involved?
Investigator(s):	Chiu K, So KF, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Chiu K., So K.F. and Chang R.C.C., Progressive neurodegeneration of retina in Alzheimer’s disease: Are beta-amyloid peptide and tau new pathological factors in glaucoma?, In: Shimon Rumelt, Glaucoma - Basic and Clinical Aspects. InTech Open Assess Publisher, 2012, 157-177.

Ho W.L., Leung Y., Tsang A.W.-.T., So K.F., Chiu K. and Chang R.C.C., Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?, Molecular Vision. 2012, 18: 2700-2710.

Poon C.H., Ho Y.S., Chiu K. and Chang R.C.C., Cytokines: how important are they in mediating sickness?, Neuroscience and Biobehavioral Review. 2013, 37: 1-10.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

Researcher : Chung SK

Project Title:	The role of exchange protein directly activated by cAMP Epac in diabetic painless and painful neuropathy
Investigator(s):	Chung SK
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Chung SK
Department:	Anatomy
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury
Investigator(s):	Chung SK
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2012

Project Title:	The pathogenesis of dopaminergic neuronal loss in Parkinson’s disease and therapeutic restoration of dopaminergic neurons
Investigator(s):	Chung SK
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

List of Research Outputs

CHEN Y., Tai A.C.P., Kai A.K.L., Tam S., Lam K.S.L., Chung S.S.M., Xu A. and Chung S.K., Exchange protein directly activated by cAMP plays an important role in b3-adrenergic induction of UCP1 in WAT and thermogenesis via regulating lipolysis, American Diabetes Association 73rd Scientific Sessions, June 21-25, 2013, Chicago, Illinois, U. S. A.. 2013, 62 Suppl. 1A.

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity, PLOS ONE. 2012, 7(12): e52354.

Chan K.H., Lam K.S.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Ho W.M., Guo Y. and Xu A., Adiponectin is protective against oxidative stress-induced cytotoxicity in amyloid-beta neurotoxicity, 18th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2013. 19 (Suppl 1): 10.

Chen Y. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue., Anatomy Postgraduate Symposium. 2012.

Chung S.K., Chung S.S.M. and Chihiro H., Protective agent for retinal nerve or optic nerve, 2013, Patent No. 13155114.5 - 1464.

Chung S.K., Role of aldose reductase in nervous system disorders using genetic and pharmacological manipulations, 20th Anniversary of the Founding of the PLA Institute of Neuroscience & International Conference on Central Nervous System Disorder, Xian, China. 2012.

Feng Q., Chang R.C.C., Chung S.K. and So K.F., Investigation of Iba1+/NG2++cells in the adult mouse retina after ischemia-reperfusion injury with or without Lycium Barbarum polysaccharide treatment, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 182 No. 2.08.

Feng Q., Chung S.K. and So K.F., Investigation of Non-Vascular NG2 Expressing Cells in the Adult Mouse Retina after Ischemia-Reperfusion Injury., The 8th FENS Froum of Neuroscience. 2012.

Fu Z., Li S.Y., Kociok N., Wong D.S.H., Chung S.K. and Lo A.C.Y., Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy, Investigative Ophthalmology & Visual Science. 2012, 53: 5698-5712.

Hung K.L., CHEN S.M.Y., TAI W.L., Chen A.Y.S., Chung S.K. and Cheung C.W., Over expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection, Life Sciences. . Elsevier Ltd, 2012, 91(13-14): 618-622.

Hung K.L., Chen S.M.Y., Tai W.L., Chung S.K. and Cheung C.W., Targeted over-expressionof endothelin-1 in the astrocytes amedliorates mechanicak hyperalgesia induced by sciatic nerve ligation injury, 14th World Pain Congress on Pain. Milan, Italy. 27t to 31st August 2012.

Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.

Li F.Y.L., Baretella O., Tang E.H.C., Vanhoutte P.M., Lam K.S.L., Chung S.K. and Xu A., Tie-1dependent endothelial cell restricted over-expression of endothelin-1 paradoxically impairs vascular contractions response to serotonin, ET-12 meeting, London, 2012.

Mi X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, The 8th ISO-HK, Dec. 14, 2012, Hong Kong. 2012.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

TIRRELL L., Cheung C.W. and Chung S.K., Rho GTPase-activating protein DLC2 deficiency in mice leads to more severe painful diabetic neuropathy, American Diabetes Association, 73rd Scientific Sessions, June 21-25, 2013, Chicago, Illinois, U. S. A.. 2013.

Xian Z. and Chung S.K., Deficiency of Epac2 leads to more severe neurological deficit and neuronal cell death in experimental stroke condition., Department Symposium (Anatomy Postgraduate Symposium). 2012.

Zhang X., Yeung P.K.K., McAlonan G.M., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion, Neurobiology of Learning and Memory. 2013, 101: 46-54.

Zhou L. and Chung S.K., Epac1 is involved in modulating hyperalgesic response to noxious inflammatory stimulus., The 16th Research Postgraduate Symposium. 2012.

Researcher : DAI Y

List of Research Outputs

DAI Y., PAN Y. and Yip H.K.F., Effect Of Combined Treatment Of Lithium And Noggin On The Neural Progenitor Cells And Neurogenesis After Chronically Injured Adult Spinal Cord. , Eighth International Symposium On Health Aging. 2013.

DAI Y., PAN Y. and Yip H.K.F., Effect Of The Combined Lithium And Noggin Treatment On The Responses Of Neural Progenitor Cells And Functional Recovery After Chronic Spinal Cord Injury In Adult Mice, US Society of Neuroscience Annual Meeting. 2013.

Researcher : Deng W

Project Title:	Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW, Huen MSY, Tsang CM
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities
Investigator(s):	Deng W, Tsao GSW
Department:	School of Nursing
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., MicroRNA-135a regulates cervical cancer transformation and progression through ß-catenin via a SIAH1-dependent ubiquitin-proteosomal pathway, The 19th Hong Kong International Cancer Congress. 2012.

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., Role of microRNA-135a in cervical cancer transformation and development., The 17th Research Postgraduate Symposium. 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., Lo K.W., Hau P.M., LAU M.Y. and Takada K., Cyclin D1 expression supports stable EBV infection in nasopharyngeal carcinoma, Proc Natl Acad Sci U S A. 2012, 109(50):: E3473-82.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., LAU M.Y., Takada K., Lui V.W. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proc Natl Acad Sci USA. 2012, 109(50): E3473-82.

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.

Researcher : Deng W.

Project Title:	Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW, Huen MSY, Tsang CM
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities
Investigator(s):	Deng W, Tsao GSW
Department:	School of Nursing
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Researcher : Ellis-Behnke RG

Project Title:	The ADME of Self-assembling Nanomaterials
Investigator(s):	Ellis-Behnke RG
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2008

Project Title:	Incorporation Dynamics of Additives and Self-assembly peptides (SAPs) at Nanoscale for Central Nervous System (CNS) Regeneration
Investigator(s):	Ellis-Behnke RG
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Self-assembling Peptides (SAPs) at Nanoscale for Blood Preservation
Investigator(s):	Ellis-Behnke RG
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2009

List of Research Outputs

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.

Wu K.S., Li S.Y., Lo A.C.Y., Ngan A.H.W., Wong D.S.H., So K.F., Ellis-Behnke R.G. and Tang B., Micro-scale stiffness change of cornea tissues suffered from elevated intraocular pressure investigated by nanoindentation , Soft Materials. Taylor & Francis, 2013, 11: 244-253.

Researcher : Feng Q

List of Research Outputs

Feng Q., Chang R.C.C., Chung S.K. and So K.F., Investigation of Iba1+/NG2++cells in the adult mouse retina after ischemia-reperfusion injury with or without Lycium Barbarum polysaccharide treatment, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 182 No. 2.08.

Feng Q., Chung S.K. and So K.F., Investigation of Non-Vascular NG2 Expressing Cells in the Adult Mouse Retina after Ischemia-Reperfusion Injury., The 8th FENS Froum of Neuroscience. 2012.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

Researcher : Feng W

Project Title:	Understanding the molecular mechanisms of TRAIP-dependent responses to genotoxic stress
Investigator(s):	Feng W, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	12/2012

List of Research Outputs

Chen J., Feng W. and Huen M.S.Y., DYRK1A is an RNF169-interacting partner involved in DNA damage signaling, International Symposium on DNA Damage Response & Human Diseases - Beijing 2012 (isDDRHD-Beijing 2012). 2012.

Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., Ring Finger Protein RNF169 Antagonises The Ubiquitin-dependent Signaling Cascade At Sites Of Dna Damage, Journal of Biological Chemistry. 2012, In Press.

Researcher : Fu Z

List of Research Outputs

Fu Z., Li S.Y., Kociok N., Wong D.S.H., Chung S.K. and Lo A.C.Y., Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy, Investigative Ophthalmology & Visual Science. 2012, 53: 5698-5712.

Researcher : Fung MY

List of Research Outputs

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Researcher : GUO R

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise ameliorates left ventricular hypertrophy induced by high fat diet in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P29, 3/2013.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Guo R., Fung M.L., Liong E.C. and Tipoe G.L., Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future chanllenges, Hepatobiliary Pancreatic Diseases International. 2013, 12: 125-135.

Researcher : Guo R

List of Research Outputs

Researcher : HAU PM

List of Research Outputs

Tsang C.M., Yip Y.L., Lo K.W., Deng W., Lo K.W., Hau P.M., LAU M.Y. and Takada K., Cyclin D1 expression supports stable EBV infection in nasopharyngeal carcinoma, Proc Natl Acad Sci U S A. 2012, 109(50):: E3473-82.

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.

Yip Y.L., Pang P.S., Deng W., Tsang C.M., Hau P.M. and Tsao G.S.W., Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells, Joint Spring Conference of British Societies for Cell Biology and Developmental Biology. 2013.

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Han L

List of Research Outputs

Han L., Li B., Tsao G.S.W. and Cheung A., Identification of microRNAs that target Id-1 in esophageal cancer, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013, Washington, U. S. A.. 2013, Abstract No. 1959.

Han L., Li B., Tsao G.S.W. and Cheung A., MicroRNAs Targeting Id-1 Exhibit Tumor Suppressive Effects in Esophageal Cancer, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Researcher : Hau PM

Project Title:	The importance of ATM DNA damage signaling in Epstein-Barr virus lytic replication in infected epithelial cells
Investigator(s):	Hau PM, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011
Completion Date:	05/2013

List of Research Outputs

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Researcher : Ho YS

Project Title:	Investigating the potential of anti-inflammatory cytokine Interleukin-10 to attenuate synaptic degeneration in systemic inflammation-induced depression
Investigator(s):	Ho YS, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Chang R.C.C., Hung C.H.L., Zhang Q. and Ho Y.S., Characterizing the morphological changes and dynamic of mitochondria in neurons after exposure to ß-amyloid peptide., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease. Florence, Italy. 2013.

Chang R.C.C., Hung H.L., Wuwongse S., Zhang Q. and Ho Y.S., Early dynamic changes of mitochondrial morphology in hippocampal neurons in response to beta-amyloid, Society for Neuroscience. 2012, 220.13.

Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide, Alzheimer's & Dementia. 2012, 8 (4) Supplment: 252-253.

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Ho Y.S., Hung C.H.L. and Chang R.C.C., Green tea and neurodegeneration in Alzheimer's disease, In: Victor R. Preedy, Tea in Health and Disease Prevention. Elsevier Publisher, 2013, 691-704.

Ho Y.S., Chao J. and Chang R.C.C., Oxyresveratrol, an active ingredient from Mulberry fruits (Morus alba L.), reduced alpha synuclein aggregation in an in vitro model of Parkinson's disease, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 271.

Huang C., Ho Y.S., Wong G.T.C., Irwin M.G. and Chang R.C.C., The Effects of Intravenous Propofol, Dexmedetomdine, Ketamine and Isoflurance on Tau Phosphorylation in neuronal cell culture and in vivo, The International Anesthesia Research Society 2013 Annual Meeting. 2013.

Poon C.H., Ho Y.S., Chiu K. and Chang R.C.C., Cytokines: how important are they in mediating sickness?, Neuroscience and Biobehavioral Review. 2013, 37: 1-10.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

Tsang A.W.-.T., Wong T.H.G., Hung C.H.L., Cheng S.Y., Law A.C.K., Ho Y.S. and Chang R.C.C., ß-Amyloid and corticosterone-induced changes to tau protein in primary cultures of hippocampal neurons., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Researcher : Huen M.S.Y.

Project Title:	Characterization of USP34, a novel ubiquitin specific peptidase involved in the DNA Damage Response
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	07/2012

Project Title:	Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling.
Investigator(s):	Huen MSY, Sy MH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2012

Project Title:	Genomic Instability and DNA Repair ; Structural Basis for Role of Ring Finger Protein RNF168 RING Domain
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY, Sy MH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

List of Research Outputs

Researcher : Huen MSY

Project Title:	Characterization of USP34, a novel ubiquitin specific peptidase involved in the DNA Damage Response
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	07/2012

Project Title:	Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling.
Investigator(s):	Huen MSY, Sy MH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2012

Project Title:	Genomic Instability and DNA Repair ; Structural Basis for Role of Ring Finger Protein RNF168 RING Domain
Investigator(s):	Huen MSY
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY, Sy MH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

List of Research Outputs

Chen J., Feng W. and Huen M.S.Y., DYRK1A is an RNF169-interacting partner involved in DNA damage signaling, International Symposium on DNA Damage Response & Human Diseases - Beijing 2012 (isDDRHD-Beijing 2012). 2012.

Chen J., Feng W., Jiang J., Deng Y. and Huen M.S.Y., Ring Finger Protein RNF169 Antagonises The Ubiquitin-dependent Signaling Cascade At Sites Of Dna Damage, Journal of Biological Chemistry. 2012, In Press.

Guerra-Rebollo M., Mateo F., Franke K., Huen M.S.Y., Lopitz-Otsoa F., Rodriguez M.S., Plans V. and Thomson T.M., Nucleolar exit of RNF8 and BRCA1 in response to DNA damage, Exp Cell Res. 2012, 318 (18): 2365-76.

Huen M.S.Y., Early Career Award 2012-2013, University Grants Committee. 2012.

Huen M.S.Y., Regulators of ubiquitin signaling at DNA double strand breaks, International Symposium on DNA Damage Response & Human Diseases. 2012.

Sy M.H., Jiang J., Deng Y. and Huen M.S.Y., The Ubiquitin Specific Protease USP34 Promotes DNA Damage Ubiquitin Signaling, Keystone Symposia - Genomic Instability and DNA Repair. 2013.

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural Basis for Role of Ring Finger Protein RNF168 RING Domain, Keystone Symposia - Genomic Instability and DNA Repair. 2013.

Zhang X., CHEN J., Wu M., Wu H., Arokiaraj A.W.R., Wang C., Zhang W., Tao Y., Huen M.S.Y. and Zang J., Structural basis for role of Ringer Finger Protein RNF168 Ring domain, Cell Cycle. 2013, 12(2): 312-21.

Researcher : Hugon J

Project Title:	Society for Neuroscience 30th Annual Meeting Tau Phosphorylation during neuronal Apoptosis Induced by NMDA Receptor Blockade: an in Vivo Study
Investigator(s):	Hugon J
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Researcher : Hung CHL

List of Research Outputs

Chang R.C.C., Hung C.H.L., Zhang Q. and Ho Y.S., Characterizing the morphological changes and dynamic of mitochondria in neurons after exposure to ß-amyloid peptide., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease. Florence, Italy. 2013.

Ho Y.S., Hung C.H.L. and Chang R.C.C., Green tea and neurodegeneration in Alzheimer's disease, In: Victor R. Preedy, Tea in Health and Disease Prevention. Elsevier Publisher, 2013, 691-704.

Tsang A.W.-.T., Wong T.H.G., Hung C.H.L., Cheng S.Y., Law A.C.K., Ho Y.S. and Chang R.C.C., ß-Amyloid and corticosterone-induced changes to tau protein in primary cultures of hippocampal neurons., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Wong T.H.G., Hung C.H.L., Law A.C.K. and Chang R.C.C., Morphological and dynamic change in microtubules of primary cultured hippocampal neurons stressed by ß-amyloid peptide and corticosterone., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Researcher : Hung HL

List of Research Outputs

Chang R.C.C., Hung H.L., Wuwongse S., Zhang Q. and Ho Y.S., Early dynamic changes of mitochondrial morphology in hippocampal neurons in response to beta-amyloid, Society for Neuroscience. 2012, 220.13.

Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide, Alzheimer's & Dementia. 2012, 8 (4) Supplment: 252-253.

Wong T.H.G., Wuwongse S., Hung H.L., Law A.C.K. and Chang R.C.C., Degeneration of microtubules in cultured hippocampal neurons stressed by beta-amyloid peptide and corticosterone, Alzheimer's Association International Conference 2012.

Researcher : Hung WY

List of Research Outputs

Hung W.Y., The Role of TAX1BBP2 in Hepatocellular Carcinoma. 2012, 131.

Lai W.L., Hung W.Y. and Ching Y.P., Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer, In: Hepatology International, 23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER. 2013, 7 Supplement 1: Abstract No.628.

Researcher : Hung WY

List of Research Outputs

Hung W.Y., The Role of TAX1BBP2 in Hepatocellular Carcinoma. 2012, 131.

Researcher : Kai AKL

List of Research Outputs

Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.

Researcher : LAU MY

List of Research Outputs

Tsang C.M., Yip Y.L., Lo K.W., Deng W., Lo K.W., Hau P.M., LAU M.Y. and Takada K., Cyclin D1 expression supports stable EBV infection in nasopharyngeal carcinoma, Proc Natl Acad Sci U S A. 2012, 109(50):: E3473-82.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., LAU M.Y., Takada K., Lui V.W. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proc Natl Acad Sci USA. 2012, 109(50): E3473-82.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.

Researcher : Lai WL

Project Title:	An investigation on the tumour suppressor activity of Tax1 binding protein 2 in hepatocellular carcinoma
Investigator(s):	Lai WL, Ching YP
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

Project Title:	An investigation on the role of Tax1 binding protein 2 in the DNA damage response in hepatocellular carcinoma
Investigator(s):	Lai WL, Ching YP
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

Lai W.L., Hung W.Y. and Ching Y.P., Centrosomal protein TAX1BP2 is a novel tumor suppressor in liver cancer, In: Hepatology International, 23rd CONFERENCE OF THE ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER. 2013, 7 Supplement 1: Abstract No.628.

Mak W.Y.G., Lai W.L., Zhou Y., Li M., Ng I.O.L. and Ching Y.P., CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells, PLOS ONE. 2012, 7(7), pp: e42210.

Researcher : Lau WM

Project Title:	Are neurogenesis and gliogenesis involved in the neurobiology of specific phobia?
Investigator(s):	Lau WM, So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	11/2012

List of Research Outputs

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Cheng L.F.G., Zeng H., Leung M.K., Zhang H.J., Lau W.M., Liu Y.P., Liu G.X., Sham P.C., Chan C.C.H., So K.F. and Lee T.M.C., Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction, Translational Psychiatry. 2013, 3: e260.

Ho R.T.H., Chan J.S.M., Ng S.M., Lau W.M., So K.F., Cheung K.M., Ng B.F.L., Ziea E.T.C. and Chan C.L.W., The regulation of HPA activity and anti-aging effect of Qigong exercise for patients with chronic fatigue syndrome: telomerase activity and salivary cortisol (Presented at the 34th Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine, March 20-23, 2013, San Francisco, California, U.S.), Annals of Behavioral Medicine. 2013, 45(S2): s307, D-213.

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Ren C., Luan L., Lau W.M., Huang X., Yang J., Zhou Y., Wu X., Gao J., Pickard G.E., So K.F. and Pu M., Direct retino-raphe projection alters serotonergic tone and affective behavior, Neuropsychopharmacology. 2013, 38: 1163-1175.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Researcher : Lee CD

List of Research Outputs

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Researcher : Lee VWH

List of Research Outputs

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Researcher : Leung MC

List of Research Outputs

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

Researcher : Leung TM

List of Research Outputs

Lau T.H.Y., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji A.A., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Lau T.Y.H., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji J., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Researcher : Leung WH

List of Research Outputs

Leung W.H., Ching Y.P. and So K.F., The potential role of fetal bovine serum (FBS) as positive control for studying neural stem cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12 & 13, 2012, Hong Kong. 2012, No. 2.15.

Researcher : Leung Y

List of Research Outputs

Chao J., Leung Y., Wang M. and Chang R.C.C., Nutraceuticals and their preventive or potential therapeutic value for Parkinson's disease, Nutrition Reviews. 2012, 70: 373-386.

Ho W.L., Leung Y., Tsang A.W., So K.F. and Chang R.C.C., Review: Tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain?, Molecular Vision 2012. 2012, 18: 2700 - 2710.

Ho W.L., Leung Y., Tsang A.W.-.T., So K.F., Chiu K. and Chang R.C.C., Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?, Molecular Vision. 2012, 18: 2700-2710.

Researcher : Leung Y

List of Research Outputs

Chao J., Leung Y., Wang M. and Chang R.C.C., Nutraceuticals and their preventive or potential therapeutic value for Parkinson's disease, Nutrition Reviews. 2012, 70: 373-386.

Researcher : Li A

List of Research Outputs

Li A., Yau S.Y., Xu A. and So K.F., Enhanced proliferation of hippocampal neural progenitor cells following activation of adiponectin receptor 1, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong. . 2012, No. 2.16.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Researcher : Li B

Project Title:	Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer
Investigator(s):	Li B, Cheung A
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Cheung A., Li B., Tsao G.S.W. and Chan K.W., Id1-induced IGF2 Promotes Tumor Angiogenesis by Paracrine Activation of Stromal Fibroblasts, In: Proceedings of the Meeting of the 22nd Biennial Congress of the European Association for Cancer Research; 2012 July 7-10; Barcelona, Spain. (EACR). 2012, 48 Supplement 5: S95.

Han L., Li B., Tsao G.S.W. and Cheung A., Identification of microRNAs that target Id-1 in esophageal cancer, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013, Washington, U. S. A.. 2013, Abstract No. 1959.

Han L., Li B., Tsao G.S.W. and Cheung A., MicroRNAs Targeting Id-1 Exhibit Tumor Suppressive Effects in Esophageal Cancer, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBX031 functions as an oncoprotein by suppressing a apoptosis via regulation of MAPK pathway in esophageal squamous cell carcioma cell lines, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013 Washington, U. S. A.. 2013, Abstract No. 4305.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBXO31 Suppresses Apoptosis of Esophageal Cancer Cells via Regulation of MAPK Pathway, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Researcher : Li H

List of Research Outputs

Li H., Secondary Degeneration after Partial Optic Nerve Transection: Mechanisms and the Neuroprotective Effects of Lycium Barbarum. 2013, 160.

Researcher : Li J

List of Research Outputs

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Researcher : Li RHW

Project Title:	An in vitro study of endocrine factors regulating expression of anti-Mullerian hormone in human granulosa cells
Investigator(s):	Li RHW, Yeung WSB, Cheung ANY, Ng EHY, Ho PC, O WS
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2013

Project Title:	First Global Conference on Contraception, Reproductive and Sexual Health ; Ulipristal acetate may contribute to contraceptive action by its effects on tubal function
Investigator(s):	Li RHW
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

List of Research Outputs

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

Researcher : Li X

List of Research Outputs

Li X., Lin B. and So K.F., The role of retinal-raphe projection in the light therapy for non-seasonal major depression, 17th Research Postgraduate symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 96 2.24.

Researcher : Liang Y

List of Research Outputs

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.

Researcher : Liao S

List of Research Outputs

Chen H., Liao S., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands, Free Radical Biology and Medicine. 2012, 53: 885-892.

Liao S., Wong P.F., O W.S., Cheung B.M.Y. and Tang F., Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat, 2012, 31-37.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

Researcher : Lin B

Project Title:	Restoring visual function after photoreceptor degeneration: ectopic expression of photosensitive proteins in retinal neurons.
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Mechanisms of the Secondary Degeneration of Retinal Cone Photoreceptors in Retinitis Pigmentosa (RP)
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

Project Title:	Protection and Restoration of cone photoreceptors by a novel multifunctional drug and its neuroprotective molecular mechanisms in one mouse model of retinitis pigmentosa
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Artificial photoreceptors created by using an optogenetic approach
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

Project Title:	The role of gap junctions in retinal degeneration
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

Li X., Lin B. and So K.F., The role of retinal-raphe projection in the light therapy for non-seasonal major depression, 17th Research Postgraduate symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 96 2.24.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

Researcher : Ling MT

Project Title:	The regulation and role of Id-1 in prostate cancer progression
Investigator(s):	Ling MT, Wong YC, Wang X
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	The role of EMI1 in prostate carcinogenesis
Investigator(s):	Ling MT, Wang X
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2007

Project Title:	The role of Daxx in chromosome instability and prostate carcinogenesis
Investigator(s):	Ling MT, Wong YC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2008

Project Title:	Effect of Tocotrienol in the inhibition of hormone refractory prostate cancer
Investigator(s):	Ling MT, Wong YC
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	08/2008

Researcher : Liong EC

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

Lam S.S.Y., LIU Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia , Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Colin Nurse, Constancio Gonzalez, Chris Peers, Nanduri R. Prabhakar Springer, New York (ISBN 978-94-007-4583-4) . 2012, 758: 301-306.

Lam S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, In: C.A. Nurse et al, Arterial chemoreception: From Molecules to Systems, Advances in Experimental Medicine and Biology. Springer Science+Business Media Dordrecht, 2012, 758: chapter 41 301-306.

Lau T.H.Y., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji A.A., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Lau T.Y.H., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji J., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Nanji A.A., Liong E.C., Xiao J. and Tipoe G.L., Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations, Alcoholism Clinical and Experimental Research. 2013, 37(1): 31-39.

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., So K.F., Liong E.C. and Tipoe G.L., Recent advances in the herbal treatment of non-alcoholic fatty liver disease, Journal of Traditional and Complementary Medicine. 2013, 3 No. 2: 88-94.

Xiao J., Guo R., Fung M.L., Liong E.C. and Tipoe G.L., Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future chanllenges, Hepatobiliary Pancreatic Diseases International. 2013, 12: 125-135.

Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Tipoe. Garlic-derived S-allylmercaptocysteine is a novel hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2013, 52: 179-191.

Researcher : Liu J

List of Research Outputs

Liu J., Li B., Tsao G.S.W. and Cheung A., FBX031 functions as an oncoprotein by suppressing a apoptosis via regulation of MAPK pathway in esophageal squamous cell carcioma cell lines, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013 Washington, U. S. A.. 2013, Abstract No. 4305.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBXO31 Suppresses Apoptosis of Esophageal Cancer Cells via Regulation of MAPK Pathway, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Researcher : Lok CKM

List of Research Outputs

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

Researcher : Ma CHS

List of Research Outputs

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Researcher : Mak WYG

List of Research Outputs

Mak W.Y.G., Lai W.L., Zhou Y., Li M., Ng I.O.L. and Ching Y.P., CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells, PLOS ONE. 2012, 7(7), pp: e42210.

Researcher : Man CWY

Project Title:	The polycomb group protein, Bmi-1, induces supernumerary centrosomes and chromosome instability through Id1 in immortalized nasopharyngeal epithelial cells
Investigator(s):	Man CWY, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Researcher : Mi X

List of Research Outputs

Mi X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, The 8th ISO-HK, Dec. 14, 2012, Hong Kong. 2012.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

Researcher : Mi X

List of Research Outputs

Researcher : O WS

Project Title:	A CASE-CONTROL IN-VITRO STUDY ON THE POSSIBLE ROLE OF ADRENOMEDULLIN AND ENDOTHELIN IN PATHOGENESIS OF TUBAL ECTOPIC PREGNANCY
Investigator(s):	O WS, Tang F
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	09/2012

Project Title:	Adrenomedullin - a promising diagnostic marker for tubal ectopic pregnancy
Investigator(s):	O WS, Tang F, Ho JCM
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

Project Title:	Society for Reproduction and Fertility Conference 2012 Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium
Investigator(s):	O WS
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012
Completion Date:	07/2012

List of Research Outputs

Chen H., Liao S., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands, Free Radical Biology and Medicine. 2012, 53: 885-892.

Li L., Ma P., Liu Y., Huang C., O W.S., Tang F. and Zhang J.V., Intermedin attenuates LPS-induced inflammation in the rat testis, PLOS ONE. 2013, 8(6): e65278.

Li R.H.W., Liao S., Yeung W.S.B., Ng E.H.Y., O W.S. and Ho P.C., Ulipristal acetate may contribute to contraceptive action by its effects on tubal function, The European Journal of Contraception and Reproductive Health Care. 2013, 18 (Supplement 1): S193-S194.

Liao S., Wong P.F., O W.S., Cheung B.M.Y. and Tang F., Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat, 2012, 31-37.

Liao S...B..., O W.S. and Tang F., Adrenomedullin inhibits norepinephrine-induced contraction in the rat seminal vesicle. , Urology 80, 224e.1-224e.5.. 2012.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., 36. Adrenomedullin as a biomarker for tubal ectopic pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium., Society for Reproduction and Fertility Abstract Series July 2012, #O019. 2012, 16.

O W.S., Li R.H.W., Liao S., Ho J.C.M., Ng E.H.Y., Yeung W.S.B., Cheung A.N.Y. and Tang F., Adrenomedullin as a biomarker for tubal ectopic pregnancy – new evidence from adrenomedullin function in the nasal ciliary epithelium. Society for Reproduction and fertility, Edinburgh, United Kingdom, #O019, July 2012.

O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100(2): 459-463.

O W.S., The nasal epithelium provides an easier alternative than the oviduct for the study of ciliary beating, Fertility and Sterility. 2013, 100 No. 2.

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the effects of intemedin on uterine contraction. Society for Reproduction and fertility, Edinburgh, United Kingdom, #P011, July 2012 . 2012.

Wong C.W., O W.S. and Tang F., Intermedin in reproduction: changes in gene expression and peptide levels in the ovary, oviduct and the uterus in the oestrous cycle of the rat; and the ffects of intermedin on uterine contraction., Society for Reproduction and Fertility Abstract Series July 2012, #P011. 2012, 26.

Researcher : PAN Y

List of Research Outputs

DAI Y., PAN Y. and Yip H.K.F., Effect Of Combined Treatment Of Lithium And Noggin On The Neural Progenitor Cells And Neurogenesis After Chronically Injured Adult Spinal Cord. , Eighth International Symposium On Health Aging. 2013.

DAI Y., PAN Y. and Yip H.K.F., Effect Of The Combined Lithium And Noggin Treatment On The Responses Of Neural Progenitor Cells And Functional Recovery After Chronic Spinal Cord Injury In Adult Mice, US Society of Neuroscience Annual Meeting. 2013.

Researcher : Pang PS

List of Research Outputs

Yip Y.L., Pang P.S., Deng W., Tsang C.M., Hau P.M. and Tsao G.S.W., Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells, Joint Spring Conference of British Societies for Cell Biology and Developmental Biology. 2013.

Researcher : Poon CH

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Poon C.H., Ho Y.S., Chiu K. and Chang R.C.C., Cytokines: how important are they in mediating sickness?, Neuroscience and Biobehavioral Review. 2013, 37: 1-10.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Impact of double-stranded RNA-dependent protein kinase (PKR) on inflammation and sickness induced by bacterial infection., The 20th Hong Kong Society of Immunology Meeting, Hong Kong. 2013, 17.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Modulation of bacteria-induced sickness and inflammation by double-stranded RNA-dependent protein kinase (PKR)., International “Stress and Behavior” Neuroscience Conference, St. Petersburg, Russia. 2013, 18.

Poon C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Significant roles of double-stranded RNA protein kinase in systemic inflammation-induced sickness., The 8th International Conference of Healthy Aging, Hong Kong. 2013, 62.

Researcher : Qin D

List of Research Outputs

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Researcher : Sang Y

List of Research Outputs

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Researcher : So K.F.

Project Title:	Role of JNK3/APP signaling pathway in modulating the apoptosis of optic axotomized retinal ganglion cells
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	Hippocampal plasticity in adiponectin knock-out mice and diabetic mice
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	06/2013

Project Title:	XiangShan Science Conference: The 425th Session: Intelligent Biomedical Polymers: Frontiers and Applications Protection and Regeneration of the Central Nervous System
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	05/2015

List of Research Outputs

Researcher : So KF

Project Title:	Role of JNK3/APP signaling pathway in modulating the apoptosis of optic axotomized retinal ganglion cells
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2012

Project Title:	Hippocampal plasticity in adiponectin knock-out mice and diabetic mice
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	06/2013

Project Title:	XiangShan Science Conference: The 425th Session: Intelligent Biomedical Polymers: Frontiers and Applications Protection and Regeneration of the Central Nervous System
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects
Investigator(s):	So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	05/2015

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Cheng L.F.G., Zeng H., Leung M.K., Zhang H.J., Lau W.M., Liu Y.P., Liu G.X., Sham P.C., Chan C.C.H., So K.F. and Lee T.M.C., Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction, Translational Psychiatry. 2013, 3: e260.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortium for Globalization of Chinese Medicine, August 21-23, 2012, Macao. 2012, No. 274.

Chiu K., Li J., Liang Y., Chang R.C.C., Lee V.W.H. and So K.F., Neuroprotective effect of delayed trans-scleral electrical stimulation on axotomized damage in the rat retina, The 11th Meeting of Consortum for Globalization of Chinese Medicine. 2012, 274.

Chiu K., So K.F. and Chang R.C.C., Progressive neurodegeneration of retina in Alzheimer’s disease: Are beta-amyloid peptide and tau new pathological factors in glaucoma?, In: Shimon Rumelt, Glaucoma - Basic and Clinical Aspects. InTech Open Assess Publisher, 2012, 157-177.

Feng J., Xu Y., Ruan Y.W., So K.F., Tissir F., Goffinet A. and Zhou L.B., A Role for Atypical Cadherin Celsr3 in Hippocampal Maturation and Connectivity, The Journal of Neuroscience. 2012, 32(40): 13729 - 13743.

Feng Q., Chang R.C.C., Chung S.K. and So K.F., Investigation of Iba1+/NG2++cells in the adult mouse retina after ischemia-reperfusion injury with or without Lycium Barbarum polysaccharide treatment, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 182 No. 2.08.

Feng Q., Chung S.K. and So K.F., Investigation of Non-Vascular NG2 Expressing Cells in the Adult Mouse Retina after Ischemia-Reperfusion Injury., The 8th FENS Froum of Neuroscience. 2012.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

Ho R.T.H., Chan S.M., Wang C., Lau B.W.M., So K.F., Yuen L.P., Sham J.S.T. and Chan C.L.W., A randomized controlled trial of qigong exercise on telomerase activity in persons with chronic fatigue and chronic fatigue syndrome , Annals of Behaviorial Medicine. 2012, 44: 160-170.

Ho R.T.H., Chan J.S.M., Ng S.M., Lau W.M., So K.F., Cheung K.M., Ng B.F.L., Ziea E.T.C. and Chan C.L.W., The regulation of HPA activity and anti-aging effect of Qigong exercise for patients with chronic fatigue syndrome: telomerase activity and salivary cortisol (Presented at the 34th Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine, March 20-23, 2013, San Francisco, California, U.S.), Annals of Behavioral Medicine. 2013, 45(S2): s307, D-213.

Ho W.L., Leung Y., Tsang A.W., So K.F. and Chang R.C.C., Review: Tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain?, Molecular Vision 2012. 2012, 18: 2700 - 2710.

Ho W.L., Leung Y., Tsang A.W.-.T., So K.F., Chiu K. and Chang R.C.C., Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?, Molecular Vision. 2012, 18: 2700-2710.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Lau W.M., Lee C.D., Fung M.Y., Sang Y., Shen J., Chang R.C.C. and So K.F., The Use of Chinese Herbal Medicine for Neurodegenerative Diseases: Polysaccharides from Wolfberry Prevents Corticosterone-induced Inhibition of Sexual Behavior in Stressed Rats by Regulating Neurogenesis, Hong Kong International Integrative Medicine Conference 2012 - Chinese Medicine in Geriatrics. 2012年香港國際中西醫結合會議 - 中醫老年醫學, 2012, 53.

Lee T.M.C., LEUNG M.K., Hou W.K., Tang J.C.Y., Jing Y., So K.F., Lee C.F. and Chan C.C.H., Distinct neural activity associated with focused-attention meditation and loving-kindness meditation, PLoS One. 2012, 7: e40054.

Lee T.M.C., Chau B.K., So K.F. and Chan C.C.H., Potential application of cross-modal stimulation for neurorehabilitation: The relatedness of performance on tasks measuring cognitive processes subserved by similar prefrontal substrates, Journal of Rehabilitation Medicine. 2012, 44: 727-732.

Leung M.K., Chan C.C.H., Yin J., Lee C.F., So K.F. and Lee T.M.C., Increased gray matter volume in the right angular and posterior parahippocampal gyri in loving-kindness meditators, SCAN. 2013, 8: 34-39.

Leung W.H., Ching Y.P. and So K.F., The potential role of fetal bovine serum (FBS) as positive control for studying neural stem cell migration, 17th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 12 & 13, 2012, Hong Kong. 2012, No. 2.15.

Li A., Yau S.Y., Xu A. and So K.F., Enhanced proliferation of hippocampal neural progenitor cells following activation of adiponectin receptor 1, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong. . 2012, No. 2.16.

Li X., Lin B. and So K.F., The role of retinal-raphe projection in the light therapy for non-seasonal major depression, 17th Research Postgraduate symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong.. 2012, 96 2.24.

Mi X., Lo A.C.Y., Chung S.K. and So K.F., Progressive retinal degeneration in transgenic mice with over-expression of endothelin-1 in vascular endothelial cells, The 8th ISO-HK, Dec. 14, 2012, Hong Kong. 2012.

Mi X., Feng Q., Lo A.C.Y., Chang R.C.C., Lin B., Chung S.K. and So K.F., Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension, PLOS ONE. 2012, 7, Issue10: 1 - 11.

Mi X.S., Zhong J.X., Chang R.C.C. and So K.F., Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma, Journal of Integrative Medicine. 2013, 11(4): 233-240.

Ren C., Luan L., Lau W.M., Huang X., Yang J., Zhou Y., Wu X., Gao J., Pickard G.E., So K.F. and Pu M., Direct retino-raphe projection alters serotonergic tone and affective behavior, Neuropsychopharmacology. 2013, 38: 1163-1175.

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.

So K.F., Bringing modernized Chinese medicines from bench side to bed side, using Gouqizi as an example, Seminar on Chinese Medicine, September 14, 2012, Hong Kong. 2012.

So K.F. and Young W., China spinal cord injury network(ChinaSCINet): Clinical trial network, The 6th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC), April13-15, 2013, Hsinchu Taiwan. 2013, 71.

So K.F., Functional role of endogenous neural stem cells, 2nd International Neural Regeneration Symposium (INRS2012), September 21-23, 2012, Shenyang, China. 2012, 3-4.

So K.F., Functional significance of adult neurogenesis in the mammalian brain, The 24th Chinese Spine and Spinal Cord Conference, August 3-5, 2012, Changchun, China. 2012, 2/466.

So K.F., Molecular mechanism of neuroprotection in degenerative eye diseases using Gouqizi (Wolfberry), Summit on Quality Research and Drug Discovery in Chinese Medicines, April 16-17, Macau. 2013, 24.

So K.F. and Chang R.C.C., Molecular mechanism of neuroprotection in neurodegenerative diseases using Gouqizi (Wolfberry), The 1st International Chinese Symposium on Free Radical Research, the 5th Symposium for three districts of Cross-straits on Free Radical Research & the 8th National Symposium on free Radical Research, August 7-9, 2012, China. 2012.

So K.F. and Fu Q.L., Neuroprotection of retinal ganglion cells in glaucoma by blocking LINGO-1 function, or using Nogo-66 receptor antagonist, Asian Retina Meeting 2012, October 27-28, Hsinchu, Taiwan. 2012, 18-19.

Su H., Wang L., Huang W., Qin D., Cai J., Yao X., Feng C., Li Z., Wang Y., So K.F., Pan G., Wu W. and Pei D., Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells, Stem Cell Research. 2013, 10: 338-348.

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Wang L., Wang L., Huang W., Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., Wu W. and So K.F., Generation of integration-free neural progenitor cells from cells in human urine, Nature Methods. 2013, 10(1): 84-89.

Wang S., Qiu D., So K.F., Wu E.X., Leung L.H., Gu J. and Khong P.L., Radiation induced brain injury: assessment of white matter tracts in a pre-clinical animal model using diffusion tensor MR imaging, Journal of Neurooncology. 2013, 112(1): 9-15.

Wu K.S., Li S.Y., Lo A.C.Y., Ngan A.H.W., Wong D.S.H., So K.F., Ellis-Behnke R.G. and Tang B., Micro-scale stiffness change of cornea tissues suffered from elevated intraocular pressure investigated by nanoindentation , Soft Materials. Taylor & Francis, 2013, 11: 244-253.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., So K.F., Liong E.C. and Tipoe G.L., Recent advances in the herbal treatment of non-alcoholic fatty liver disease, Journal of Traditional and Complementary Medicine. 2013, 3 No. 2: 88-94.

YANG D., Chang R.C.C., So K.F., Wong D.S.H. and Lo A.C.Y., Lycium barbarum extracts preserve retinal function and reduce neuronal damage in a mouse model of transient retinal ischemia, ARVO 2013 Annual Meeting. 2013.

YAU S.Y., LAU B.W.M., Lee T.M.C. and So K.F., Differential behavioral outcome of anxiety tests in runner rats treated with corticosterone, Journal of Neuroscience and Behavioral Health. 2013, 5: 5-12.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Yip K.K., Lo C.L., So K.F., Poon M.Y. and Leung C.P., Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains, Neural Regeneration Research. 2012, 7, Issue 24: 1859 - 1865.

Young W. and So K.F., ChinaSCINet clinical trials of umbilical cord blood mononuclear cell and lithium treatment of chronic spinal cord injury, The 6th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC), April 13-15, 2013, Hsinchu, Taiwan. 2013, 73.

Zhan H., Sun S.J., Cai J., Li Y.Q., Hu C.L., Lee D.H.S., So K.F. and Li X., The effect of an NgR1 antagonist on the neuroprotection of cortical axons after cortical infarction in rats, Neurochemical Research. 2013, 38: 1333-1340.

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Zhang Y.K., Wang J., Liu L., Chang R.C.C., So K.F. and Ju G., The effect of Lycium Barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats, BMC Complementary and Alternative Medicine. 2013.

郑爽., 陈有.和., So K.F. and Young W., 中国脊髓损伤研究协作組(ChinaSCINet): 脊髓损竻临床试验阕络, 双清沦坛2012年10月13-14曰中国, 2012, 81: 12-13.

Researcher : Su H

List of Research Outputs

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Wang L., Wang L., Huang W., Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., Wu W. and So K.F., Generation of integration-free neural progenitor cells from cells in human urine, Nature Methods. 2013, 10(1): 84-89.

Researcher : Sy MH

Project Title:	genomic instability and dna repair (X6); The Ubiquitin Specific Protease USP34 Promotes DNA Damage Ubiquitin Signaling
Investigator(s):	Sy MH
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0
Investigator(s):	Sy MH, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Sy M.H., Jiang J., Deng Y. and Huen M.S.Y., The Ubiquitin Specific Protease USP34 Promotes DNA Damage Ubiquitin Signaling, Keystone Symposia - Genomic Instability and DNA Repair. 2013.

Researcher : Sy SMH

Project Title:	genomic instability and dna repair (X6); The Ubiquitin Specific Protease USP34 Promotes DNA Damage Ubiquitin Signaling
Investigator(s):	Sy MH
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

Project Title:	Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0
Investigator(s):	Sy MH, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Researcher : TIRRELL L

List of Research Outputs

TIRRELL L., Cheung C.W. and Chung S.K., Rho GTPase-activating protein DLC2 deficiency in mice leads to more severe painful diabetic neuropathy, American Diabetes Association, 73rd Scientific Sessions, June 21-25, 2013, Chicago, Illinois, U. S. A.. 2013.

Researcher : Tipoe GL

Project Title:	Thromboxane inhibitors reverse the inflammatory and fibrotic changes in rat liver despite continued ethanol administration.
Investigator(s):	Tipoe GL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011
Completion Date:	01/2013

Project Title:	The protective effects of Wolfberry (Lycium Barbarium Polysaccharide; LBP) in a clinically relevant orally fed non-alcoholic fatty liver disease (NAFLD) rat model
Investigator(s):	Tipoe GL, Ching YP, So KF
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Garlic derived S-allylmercaptocysteine (SAMC) reduces apoptosis in non-alcoholic fatty liver disease rat model through p53-dependent pathways
Investigator(s):	Tipoe GL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2013

Project Title:	23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model
Investigator(s):	Tipoe GL
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Chan T.K., Cowling J. and Tipoe G.L., A public opinion survey: is presumed consent the answer to kidney shortage in Hong Kong?, BMJ Open. 2012, 3:e002013: 1-6.

Chan T.K. and Tipoe G.L., Should we continue treatment for M? The benefits of living, Journal of Medical Ethics. 2013, 0: 1-3.

Chan T.K. and Tipoe G.L., The best interests of persistently vegetative patients: to die rather that to live?, Journal of Medical Ethics. 2013, 0: 1-3 doi:10.1136.

Fung M.L., Tipoe G.L. and Leung P.S., Paracrine-autocrine mechanisms in the carotid body function at high altitude and in disease. Advances in High-Altitude Medicine and Hypoxic Physiology in China, Edited by Sean Sanders, Fan Ming. Science (Suppl), 66-68, 2012. (Open Access URL /http://science.imirus.com/Mpowered/book/vscim12/i8/p1). 2012.

Fung M.L., Tipoe G.L. and Leung P.S., Paracrine-autocrine mechanisms in the carotid body function at high altitude and in disease, In: Sean Sanders, Fan Ming, Advances in High-Altitude Medicine and Hypoxic Physiology in China. 2012, Science (Suppl): 66-68.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

Jiang P., Jensen M.L., Cilieborg M.S., Thymann T., Wan J.M.F., Sit W.H., Tipoe G.L. and Sangild P.T., Antibiotics increase gut metabolism and antioxidant proteins and decrease acute phase response and necrotizing enterocolitis in preterm neonates, PLOS ONE. 2012, 7: e44929.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides ameliorate hippocampal oxidative stress, inflammation and apoptosis induced by chronic intermittent hypoxia in rats, 17^th Research Postgraduate Symposium, HKU, P2.11, 12/2012.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats. The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP4, 11/2012, (Journal of the Hong Kong College of Cardiology, 20(2):54, CP4, 2012). 2012.

LAM C.S., Tipoe G.L., Chang R.C.C., Cheung K.H., So K.F. and Fung M.L., Lycium barbarum polysaccharides promote hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P14, 3/2013.

Lam S.S.Y., LIU Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia , Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Colin Nurse, Constancio Gonzalez, Chris Peers, Nanduri R. Prabhakar Springer, New York (ISBN 978-94-007-4583-4) . 2012, 758: 301-306.

Lam S.Y., Liu Y., Liong E.C., Tipoe G.L. and Fung M.L., Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia, In: C.A. Nurse et al, Arterial chemoreception: From Molecules to Systems, Advances in Experimental Medicine and Biology. Springer Science+Business Media Dordrecht, 2012, 758: chapter 41 301-306.

Lau T.H.Y., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji A.A., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Lau T.Y.H., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji J., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Nanji A.A., Liong E.C., Xiao J. and Tipoe G.L., Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations, Alcoholism Clinical and Experimental Research. 2013, 37(1): 31-39.

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

PAN J., Xiao J., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces oxidative stress and apoptosis via angiotensin II receptor 1in the rat liver, 17^th Research Postgraduate Symposium, HKU, P2.29, 12/2012.

PAN J., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Telmisartan ameliorates oxidative stress and apoptosis in the liver of rats exposed to chronic intermittent hypoxia, The 16^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP7, 11/2012. Journal of the Hong Kong College of Cardiology, . 2012, 20(2):55.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise ameliorates left ventricular hypertrophy induced by high fat diet in rats, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P29, 3/2013.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., So K.F., Liong E.C. and Tipoe G.L., Recent advances in the herbal treatment of non-alcoholic fatty liver disease, Journal of Traditional and Complementary Medicine. 2013, 3 No. 2: 88-94.

Xiao J., Guo R., Fung M.L., Liong E.C. and Tipoe G.L., Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future chanllenges, Hepatobiliary Pancreatic Diseases International. 2013, 12: 125-135.

Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Tipoe. Garlic-derived S-allylmercaptocysteine is a novel hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2013, 52: 179-191.

Researcher : Tsang AW

List of Research Outputs

Chang R.C.C., Ho Y.S., Wong T.H.G., Tsang A.W., Poon C.H., Cheng S.Y., Law A.C.K., Chiu K., Lau B.W.M., Mak J.C.W. and So K.F., Biological mechanisms of risk factors leading to Alzheimer's Disease and dementia, The 7th Annual Scientific Meeting, Hong kong Society of Biological Psychiatry/Enhancement and Erasure of Memory, April 26-27, 2013, Hong Kong. 2013.

Ho W.L., Leung Y., Tsang A.W., So K.F. and Chang R.C.C., Review: Tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain?, Molecular Vision 2012. 2012, 18: 2700 - 2710.

Researcher : Tsang AW-T

List of Research Outputs

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Ho W.L., Leung Y., Tsang A.W.-.T., So K.F., Chiu K. and Chang R.C.C., Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain?, Molecular Vision. 2012, 18: 2700-2710.

Tsang A.W.-.T., Wong T.H.G., Hung C.H.L., Cheng S.Y., Law A.C.K., Ho Y.S. and Chang R.C.C., ß-Amyloid and corticosterone-induced changes to tau protein in primary cultures of hippocampal neurons., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease, Florence, Italty. 2013.

Researcher : Tsang C.M.

Project Title:	Genetic predisposition in premalignant nasopharyngeal epithelial cells to facilitate clonal and persistent EBV infection
Investigator(s):	Tsang CM, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

Project Title:	The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection
Investigator(s):	Tsang CM, Yip YL, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013

Project Title:	6th international symposium on nasopharyngeal carcinoma; Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection
Investigator(s):	Tsang CM
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Researcher : Tsang CM

Project Title:	Genetic predisposition in premalignant nasopharyngeal epithelial cells to facilitate clonal and persistent EBV infection
Investigator(s):	Tsang CM, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	06/2013

Project Title:	The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection
Investigator(s):	Tsang CM, Yip YL, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013

Project Title:	6th international symposium on nasopharyngeal carcinoma; Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection
Investigator(s):	Tsang CM
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

List of Research Outputs

Tsang C.M., Yip Y.L., Lo K.W., Deng W., Lo K.W., Hau P.M., LAU M.Y. and Takada K., Cyclin D1 expression supports stable EBV infection in nasopharyngeal carcinoma, Proc Natl Acad Sci U S A. 2012, 109(50):: E3473-82.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., LAU M.Y., Takada K., Lui V.W. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proc Natl Acad Sci USA. 2012, 109(50): E3473-82.

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.

Tsang C.M., Young Investigator Award in the 18th Hong Kong International Cancer Congress, 2012.

Tsao G.S.W., Tsang C.M., Yip Y.L., Deng W., Cheung A. and Lo K.W., Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection., American Association of Cancer Research. 2013.

Yip Y.L., Pang P.S., Deng W., Tsang C.M., Hau P.M. and Tsao G.S.W., Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells, Joint Spring Conference of British Societies for Cell Biology and Developmental Biology. 2013.

ZHU D., Yip Y.L., Deng W., Tsang C.M., Cheung A. and Tsao G.S.W., The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells, American Association of Cancer Research. 2013.

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Tsao G.S.W.

Project Title:	Cancer
Investigator(s):	Tsao GSW, Poon RTP
Department:	Anatomy
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2008

Project Title:	The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Lan HY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	The impact of Bmi-1 expression on mitosis and cancer
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2009
Completion Date:	12/2012

Project Title:	NF-kB activation in the immortalization of nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	The role of EGFR in immortalization and malignant transformation of nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells.
Investigator(s):	Tsao GSW, Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The role of IL6 on EBV-infected nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	12/2013

Project Title:	The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Chiang AKS, Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	American Association for Cancer Research Annual Meeting 2013; Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins
Investigator(s):	Tsao GSW, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Researcher : Tsao GSW

Project Title:	Cancer
Investigator(s):	Tsao GSW, Poon RTP
Department:	Anatomy
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2008

Project Title:	The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Lan HY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	The impact of Bmi-1 expression on mitosis and cancer
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2009
Completion Date:	12/2012

Project Title:	NF-kB activation in the immortalization of nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	The role of EGFR in immortalization and malignant transformation of nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2013

Project Title:	The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells.
Investigator(s):	Tsao GSW, Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The role of IL6 on EBV-infected nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	12/2013

Project Title:	The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Chiang AKS, Huen MSY
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	American Association for Cancer Research Annual Meeting 2013; Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection
Investigator(s):	Tsao GSW
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins
Investigator(s):	Tsao GSW, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

List of Research Outputs

Chan K.C., Choi M.T., Chan P.S., Lo M.C., Lo K.W., Curry J.E., Smyth T., Lee A.W., Ng W.T., Tsao G.S.W., Wong R.N., Lung M.L. and Mak N.K., Study of a novel Hsp90 inhibitor AT13387 in EBV-positive nasopharyngeal carcinoma cells. , The 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Chen H., Ko J.M.Y., Wong C.L., Hyytiainen M., Keski-Oja J., Chua D., Nicholls J.M., Cheung F., Lee A.W.M., Kwong D.L.W., Chiu P.M., Zabarovsky E., Tsao G.S.W., Tao Q., Kan P.Q.R., Chan S.H.K., Stanbridge E.J. and Lung M.L., LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvionment in nasopharyngeal carcinoma, Cancer Letters. 2012, in press.

Cheung A., Li B., Tsao G.S.W. and Chan K.W., Id1-induced IGF2 Promotes Tumor Angiogenesis by Paracrine Activation of Stromal Fibroblasts, In: Proceedings of the Meeting of the 22nd Biennial Congress of the European Association for Cancer Research; 2012 July 7-10; Barcelona, Spain. (EACR). 2012, 48 Supplement 5: S95.

Deng W., Tsao G.S.W., Guan X. and Cheung A., Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells., PLoS ONE. 2012, 7(10): e48576.

Feng Y., Wang M.N., Tong Y. and Tsao G.S.W., Berberine: an old drug but new use for liver diseases. , International Congress on Natural Products Research (ICNPR 2012). 2012.

Feng Y., Wang N., Tong Y. and Tsao G.S.W., Berberine: an old drug but new use for liver diseases, International Congress on Natural Products Research . 2012.

Han L., Li B., Tsao G.S.W. and Cheung A., Identification of microRNAs that target Id-1 in esophageal cancer, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013, Washington, U. S. A.. 2013, Abstract No. 1959.

Han L., Li B., Tsao G.S.W. and Cheung A., MicroRNAs Targeting Id-1 Exhibit Tumor Suppressive Effects in Esophageal Cancer, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung L.C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(5): 3009-3016.

Hui K.C., Lai K.Y., Chan K.W., Luk J.M.C., Lee N.P.Y., Chung M.F.Y., Cheung C.M., Srivastava G., Tsao G.S.W., Tang J.C.O. and Law S.Y.K., Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma, Medical Oncology. 2012, 29(3): 1699-1706.

Hui K.F., Lam B.H.W., Ho D.N.Y., Tsao G.S.W. and Chiang A.K.S., Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein-Barr virus, Mol Cancer Ther. 2013, 12: 747-58.

Hui K.F., Lam B.H., Ho D.N., Tsao G.S.W. and Chiang A.K.S., Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein-Barr virus, Molecular Cancer Therapeutics. 2013, 12(5).

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., MicroRNA-135a regulates cervical cancer transformation and progression through ß-catenin via a SIAH1-dependent ubiquitin-proteosomal pathway, The 19th Hong Kong International Cancer Congress. 2012.

LEUNG O.N., Pang R.T.K., YE T., Deng W., Tsao G.S.W., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., Role of microRNA-135a in cervical cancer transformation and development., The 17th Research Postgraduate Symposium. 2012.

Li L., Ying J., Li H., Zhang Y., Shu X., Fan Y., Tan J., Cao Y., Tsao G.S.W., Srivastava G., Chan A.T. and Tao Q., The human acdherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas, Oncogene. 2012, Aug 23;31(34):: 3901-12.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBX031 functions as an oncoprotein by suppressing a apoptosis via regulation of MAPK pathway in esophageal squamous cell carcioma cell lines, American Association for Cancer Research Annual Meeting 2013, April 6-10, 2013 Washington, U. S. A.. 2013, Abstract No. 4305.

Liu J., Li B., Tsao G.S.W. and Cheung A., FBXO31 Suppresses Apoptosis of Esophageal Cancer Cells via Regulation of MAPK Pathway, 19th Hong Kong International Cancer Congress, theme : Translating Innovative Research to Effective Treatment. 2012.

Lun S.W., Cheung S.T., Cheung P.F., To K.F., Woo J.K., Choy K.W., Cho C., Chung G.T., Cheng A.S., Ko C.W., Tsao G.S.W., Busson P., Ng M.H. and Lo K.W., CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma., PLoS One.. 2012, 7(12): e52426.

Ma B.B., Liu V.M., Cheung C.S., Lau C.P., Ho K.W., Hui E.P., Tsui S.K., Ng M.H., Cheng S.H., Ng P.K., Tsao G.S.W. and Chan A.T., Activity of the MEK inhibitor selumetinib (AZD6244:ARRY-142886) in nasopharyngeal cancer cell lines., Invest New Drugs. 2013, Feb;31(1): 30-8.

Ma B.B., Lui V.W., Hui C.W., Lau C.P., Wong C.H., Hui E.P., Ng M.H., Tsao G.S.W., Li Y. and Chan A.T., Preclinical evaluation of the AKT inhibitor MK-2206 in nasophayryngeal carcinoma cell lines, Invest New Drugs. 2013, Jun;31(3):: 567-75.

Shu X.S., Li L., Ji M.S., Cheng Y., Ying J.K., Fan Y., Zhong L., Liu X., Tsao G.S.W., Chan A.T. and Tao Q., FEZF2, a novel 3p14 tumour suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma, Carcinogenesis. 2013, June 20: Epubl ahead of print.

Tang K.H., Dai Y.D., Tong M., Chan Y.P., Kwan P.S., Fu L., Qin Y.R., Tsao G.S.W., Lung H.L., Lung M.L., Tong D.K.H., Law S.Y.K., Chan K.W., Ma S.K.Y. and Guan X., A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer, Cancer Reserach. 2013, 73(7): 2322-2332.

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Tsao G.S.W., Epstein-Barr virus infection and nasopharyngeal carcinoma. Division of Gastroenterology. U. of Pennsylvania. Philadelphia (Host: Dr. Hiroshi Nakagawa. 31 July 2012 , 2012.

Tsao G.S.W., Epstein-Barr virus infection and nasopharyngeal carcinoma, Center of Cancer Research, Chungnam University, Daegeon, Korea, January 2013. 2013.

Tsao G.S.W., Epstein-barr Virus Infection And Nasopharyngeal Carcinoma. Invited Lecture. Dana Farber Cancer Institute, Harvard Medical School, Boston, Usa (host: Prof. Peter Sicinski). 27 July, 2012 , 2012.

Tsao G.S.W., Tsang C.M., Yip Y.L., Deng W., Cheung A. and Lo K.W., Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection., American Association of Cancer Research. 2013.

Tsao G.S.W., The role of Epstein-Barr virus infection in nasopharyngeal carcinoma, College of Medicine, Korea University, Seoul, Korea, January, 2013. 2013.

Verillaud B.B., Gressete M., Morel Y., Paturel C.P., Herman P., Lo K.W., Tsao G.S.W., Wassef M.H., Jimenez-Pailhes A.S. and Busson P.K., Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic., Infect agent Cancer. 2012, Dec3; 7(1):: 36.

Wang N., Zhu M., Tsao G.S.W., Man K., Zhang Z. and Feng Y., Up-regulation of TIMP-1 by Genipin Inhibits MMP-2 activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma, PLOS ONE. PLOS ONE, 2012, 2012;7(9):: e46318.

Yip Y.L., Pang P.S., Deng W., Tsang C.M., Hau P.M. and Tsao G.S.W., Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells, Joint Spring Conference of British Societies for Cell Biology and Developmental Biology. 2013.

Yip Y.L. and Tsao G.S.W., Phenotypic changes in Bmi-1 immortalized nasopharyngeal epithelial cells., Hong Kong International Cancer Congress. 2012.

ZHANG L., Lee V.H.F., WONG A.M.G., Zhu Y., Dong S., KONG K.L., CHEN J., Tsao G.S.W., Guan X., Fu L. and Kwong D.L.W., MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. , Carcinogenesis . 2013, 34: 454-463.

ZHU D., Yip Y.L., Deng W., Tsang C.M., Cheung A. and Tsao G.S.W., The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells, American Association of Cancer Research. 2013.

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Tse EYT

Project Title:	Characterization of NIMA (never in mitosis gene a)-related kinase 2 (Nek2) in Hepatocellular Carcinoma (HCC)
Investigator(s):	Tse EYT, Ching YP
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Researcher : Wang X

Project Title:	The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors
Investigator(s):	Wang X, Jin D
Department:	Anatomy
Source(s) of Funding:	Lance Armstrong Foundation - General Award
Start Date:	10/2003

Project Title:	Significance of MAD2 expression to chromosomal instability in prostate cancer
Investigator(s):	Wang X
Department:	Anatomy
Source(s) of Funding:	Association for International Cancer Research - General Award
Start Date:	04/2004

Project Title:	Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells
Investigator(s):	Wang X
Department:	Anatomy
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	08/2005

Researcher : Wang X

Project Title:	Angio-(1-7) and ACE2 during normal and hypertensive pregnancy
Investigator(s):	Wang X, Ellis-Behnke RG
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008

Researcher : Wong LLY

Project Title:	An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma
Investigator(s):	Wong LLY, Ching YP
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	08/2013

List of Research Outputs

Choi M.Y., Wang Y., Wong L.L.Y., Lu B., Chen W., Huang J., Tanner J.A. and Watt R.M., The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities, PLoS ONE. 2012, 7(8): e42561.

Researcher : Wong WM

List of Research Outputs

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Wang Z., Cui J., Wong W.M., Li X., XUE W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140: 617-626.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

Researcher : Wong YC

Project Title:	Induction of breast carcinogenesis by a combination of androgens and oestrogens
Investigator(s):	Wong YC, Xie B
Department:	Anatomy
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1997

Project Title:	The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian
Investigator(s):	Wong YC, Wang X, Ho KMT
Department:	Anatomy
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

List of Research Outputs

Chiu Y.T., Tang K., Wong Y.C. and Ling M.T., Inactivation Of Atm/atr Dna Damage Checkpoint Promotes Androgen Induced Chromosomal Instability In Prostate Epithelial Cells., Plos One. 2012, 7(12): e51108.

Researcher : Wu W

Project Title:	Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury
Investigator(s):	Wu W, Yick LW, So KF
Department:	Anatomy
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	11/2003

Project Title:	Research Output Prize
Investigator(s):	Wu W, Su H, Wong WM, So KF, Wu EX
Department:	Anatomy
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	10/2008

Project Title:	Bridge the gap in nerve tissue injury to promote axonal regeneration with self-assembling peptide nanofibre scaffold (SAPNS)
Investigator(s):	Wu W
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2013

Project Title:	Influence of corticospinal tract on the survival and regeneration of spinal motor neurons after axonal injury
Investigator(s):	Wu W
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Leung G.K.K., Wang Y. and Wu W., Outstanding poster presentation: The impact of culturing techniques on the in vitro survival of transplantable cells in self-assembling peptide nanofiber scaffold, Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2012.

Sang Y., Liang Y., LIU L., Ellis-Behnke R.G., Wu W., So K.F. and Cheung R.T.F., A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection, Experimental Animals. 2013, 62: 63-69.

Su H., Wang L., Huang W., Qin D., Cai J., Yao X., Feng C., Li Z., Wang Y., So K.F., Pan G., Wu W. and Pei D., Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells, Stem Cell Research. 2013, 10: 338-348.

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Wang L., Wang L., Huang W., Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., Wu W. and So K.F., Generation of integration-free neural progenitor cells from cells in human urine, Nature Methods. 2013, 10(1): 84-89.

Wang Z., Cui J., Wong W.M., Li X., Xue W., Lin R., Wang J., Wang P., Tanner J.A., Cheah K.S.E., Wu W. and Huang J., Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development. 2013, 140(3): 617-626.

YUAN Q.J., SU H.X., CHAU W.H., Ng G.C.T., Huang J., Wu W. and Lin Z.H.I.-.X.I.U., Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease, PLoS One. 2012, V8(1): e53480.

Yuan Q.J., Su H.X., ZHANG Y., CHAU W.H., Ng G.C.T., Song Y., Huang J., Wu W. and Lin Z.X., Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway, Journal of Alzherimer's Disease. 2012, V35(4): P675-685.

Researcher : Xian Z

List of Research Outputs

Xian Z. and Chung S.K., Deficiency of Epac2 leads to more severe neurological deficit and neuronal cell death in experimental stroke condition., Department Symposium (Anatomy Postgraduate Symposium). 2012.

Researcher : Xiao J

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Guo R., Xiao J., Pan J., Liong E.C., Fung M.L., So K.F., Youdim M., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI_{4)-induced hepatic oxidative
stress, inflammation and apoptosis in vitro,
Hepathology International.
2013, 7 Supplement 1: S37 Abstract No. 2816.}

Lau T.H.Y., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji A.A., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Lau T.Y.H., Xiao J., Liong E.C., Liao L., Leung T.M., Nanji J., Fung M.L. and Tipoe G.L., Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B, Histology and Histopathology. 2013, 28: 463-471.

Nanji A.A., Liong E.C., Xiao J. and Tipoe G.L., Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations, Alcoholism Clinical and Experimental Research. 2013, 37(1): 31-39.

PAN J., Xiao J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S62, 2013). 2013.

PAN J., GUO R., Xiao J., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates oxidative stress and inflammation induced by palmitate in HepG2 cells, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P38, 3/2013.

PAN J., Xiao J., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces oxidative stress and apoptosis via angiotensin II receptor 1in the rat liver, 17^th Research Postgraduate Symposium, HKU, P2.29, 12/2012.

PAN J., Xiao J., Tipoe G.L., Huang Y. and Fung M.L., Telmisartan ameliorates oxidative stress and apoptosis in the liver of rats exposed to chronic intermittent hypoxia, The 16^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP7, 11/2012. Journal of the Hong Kong College of Cardiology, . 2012, 20(2):55.

Pan J., Xiao J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates palmitate-induced lipid accumulation and apoptosis in a NAFLD cell model, Hepatology International. 2013, 7 Supplement 1: S62 Abstract No. 2858.

Xiao J., GUO R., Fung M.L., Liong E.C., Chang R.C.C., Ching Y.P. and Tipoe G.L., Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophage, Evidence-Based Complementary and Alternative Medicine. 2013, 2013:642920.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S53, 2013). 2013.

Xiao J., Liong E.C., Ching Y.P., Chang R.C.C., So K.F., Fung M.L. and Tipoe G.L., Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in a non-alcoholic fatty liver diseases (NAFLD) rat model, Hepatology International. 2013, 7 supplement 1: S53 Abstract No. 624.

Xiao J., Protective Mechanisms of Garlic and Wolfberry Derivatives on Acute and Chronic Liver Injury Animal Models. 2012, 118.

Xiao J., So K.F., Liong E.C. and Tipoe G.L., Recent advances in the herbal treatment of non-alcoholic fatty liver disease, Journal of Traditional and Complementary Medicine. 2013, 3 No. 2: 88-94.

Xiao J., Guo R., Fung M.L., Liong E.C. and Tipoe G.L., Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future chanllenges, Hepatobiliary Pancreatic Diseases International. 2013, 12: 125-135.

Xiao J., Ching Y.P., Liong E.C., Nanji A.A., Fung M.L. and Tipoe G.L., Tipoe. Garlic-derived S-allylmercaptocysteine is a novel hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model, European Journal of Nutrition. 2013, 52: 179-191.

Researcher : Xiao J

List of Research Outputs

Xiao J., Protective Mechanisms of Garlic and Wolfberry Derivatives on Acute and Chronic Liver Injury Animal Models. 2012, 118.

Researcher : YAU SY

List of Research Outputs

Li A., Yau S.Y., Xu A. and So K.F., Enhanced proliferation of hippocampal neural progenitor cells following activation of adiponectin receptor 1, 17th Research Postgraduate Symposium, December 12 & 13, 2012, Li Ka Shing Faculty of Medicine, The University of Hong Kong. . 2012, No. 2.16.

YAU S.Y., LAU B.W.M., Lee T.M.C. and So K.F., Differential behavioral outcome of anxiety tests in runner rats treated with corticosterone, Journal of Neuroscience and Behavioral Health. 2013, 5: 5-12.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Researcher : Yang J

Project Title:	Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions
Investigator(s):	Yang J, So KF, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008

List of Research Outputs

Ren C., Luan L., Lau W.M., Huang X., Yang J., Zhou Y., Wu X., Gao J., Pickard G.E., So K.F. and Pu M., Direct retino-raphe projection alters serotonergic tone and affective behavior, Neuropsychopharmacology. 2013, 38: 1163-1175.

Researcher : Yang X

List of Research Outputs

Su H., Zhang W., Yang X., Qin D., Sang Y., Wu C., Wong W.M., Yuan Q., So K.F. and Wu W., Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve, Cell Transplantation. 2012, 21: 2651-2663.

Su H., Wang L., Cai J., Yuan Q., Yang X., Yao X., Wong W.M., Huang W., Li Z., Wan J.B., Wang Y., Pei D., So K.F., Qin D. and Wu W., Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, Stem Cell Research. 2013, 11: 529-939.

Researcher : Yau SY

Project Title:	Significance of mTOR signalling pathway in mediating the beneficial effects of physical exercise on hippocampal plasticity in stressed rats
Investigator(s):	Yau SY, So KF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

Project Title:	8th Forum of Neuroscience (FENS); Pre-running reduces depression-like behavior and restores hippocampal neurogenesis in rats treated with hige dose of corticosterone
Investigator(s):	Yau SY
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2012

List of Research Outputs

Researcher : Yeung PKK

Project Title:	The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice
Investigator(s):	Yeung PKK, Chung SK
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	09/2008

List of Research Outputs

Kai A.K.L., Lam A.K.M., Chen Y., Tai A.C.P., Zhang X., Lai A.K.W., Yeung P.K.K., Tam S., Wang J., Lam K.S.L., Vanhoutte P.M.G.R., Bos J.L., Chung S.M., Xu A. and Chung S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop b-cell dysfunction and metabolic syndrome, The FASEB Journal. 2013.

Zhang X., Yeung P.K.K., McAlonan G.M., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion, Neurobiology of Learning and Memory. 2013, 101: 46-54.

Researcher : Yip HKF

Project Title:	In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death
Investigator(s):	Yip HKF, Tsao GSW, Chung SK
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2005

Project Title:	Telomerase immortalization of retinal ganglion cells derived from the embryonic mouse retinal progenitor cells
Investigator(s):	Yip HKF, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	Combined treatment of lithium and noggin inhibits astroglios after spinal cord injury by deactivation of GSK-3β/STAT3 are BMP/Smad pathways in the endogenous adult neural stem cells
Investigator(s):	Yip HKF, Shum DKY
Department:	Anatomy
Source(s) of Funding:	Spinal Cord Injury Research Grant
Start Date:	05/2010

Project Title:	Effect of noggin on the modification of axon-growth properties of astrocytes in spinal cord injury
Investigator(s):	Yip HKF
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Lithium has an anti-inflammatory role in recovery from spinal cord injury in mice
Investigator(s):	Yip HKF
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

List of Research Outputs

DAI Y., PAN Y. and Yip H.K.F., Effect Of Combined Treatment Of Lithium And Noggin On The Neural Progenitor Cells And Neurogenesis After Chronically Injured Adult Spinal Cord. , Eighth International Symposium On Health Aging. 2013.

DAI Y., PAN Y. and Yip H.K.F., Effect Of The Combined Lithium And Noggin Treatment On The Responses Of Neural Progenitor Cells And Functional Recovery After Chronic Spinal Cord Injury In Adult Mice, US Society of Neuroscience Annual Meeting. 2013.

Yip H.K.F., Comparison of PBL teaching in the Faculty of Medicine and Dentistry at HKU, “问题为本学习方法” 在临床医学与口腔医学专业教学中的应用 , PBL and W-PBL Seminar, Guangzhou Medical University, Guangzhou, China PRC. 2013.

Yip H.K.F., Review, International Journal Of Medicine And Medical Science. 2013.

Yip H.K.F., The Role Of Bone Morphometric Proteins In Regulating Differentiation Of Retinal Progenitor Cells , University Of Washington, Dept Of Biological Structures . 2012.

Researcher : Yip YL

Project Title:	Role of cyclin D1 in immortalization and differentiation of nasopharyngeal epithelial cells
Investigator(s):	Yip YL, Tsao GSW
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011
Completion Date:	05/2013

Project Title:	Joint Spring Conference of BSCB / BSDB; Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells
Investigator(s):	Yip YL
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2013

List of Research Outputs

Tsang C.M., Yip Y.L., Lo K.W., Deng W., Lo K.W., Hau P.M., LAU M.Y. and Takada K., Cyclin D1 expression supports stable EBV infection in nasopharyngeal carcinoma, Proc Natl Acad Sci U S A. 2012, 109(50):: E3473-82.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., LAU M.Y., Takada K., Lui V.W. and Lung M.L., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proc Natl Acad Sci USA. 2012, 109(50): E3473-82.

Tsang C.M., Tsao G.S.W., Yip Y.L., Deng W. and Hau P.M., Genetic alteration enables persistent EBV infection in nasopharyngeal epithelial cells., 2012.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., HAU P.M., Takada K., Lui V.W., Lung M.L., Chen H., Zeng M., Middeldorp J.M. and Tsao G.S.W., Genetic alterations predispose nasopharyngeal epithelial cells to persistent EBV infection., 6th International Symposium on Nasopharyngeal Carcinoma. 2013.

Tsang C.M., Yip Y.L., Lo K.W., Deng W., To K.F., Hau P.M., LAU M.Y., Takada K., Liu V.W.Y. and Lung M.L., PNAS Plus: Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells, Proceedings of the National Academy of Sciences. 2012, 109: E3473-E3482.

Tsao G.S.W., Tsang C.M., Yip Y.L., Deng W., Cheung A. and Lo K.W., Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection., American Association of Cancer Research. 2013.

Yip Y.L., Pang P.S., Deng W., Tsang C.M., Hau P.M. and Tsao G.S.W., Bmi-1 over-expression and p16 knockdown efficiently immortalized nasopharyngeal epithelial cells, Joint Spring Conference of British Societies for Cell Biology and Developmental Biology. 2013.

Yip Y.L. and Tsao G.S.W., Phenotypic changes in Bmi-1 immortalized nasopharyngeal epithelial cells., Hong Kong International Cancer Congress. 2012.

ZHU D., Yip Y.L., Deng W., Tsang C.M., Cheung A. and Tsao G.S.W., The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells, American Association of Cancer Research. 2013.

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Youdim MBH

List of Research Outputs

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 ameilorates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, The Eighth International Symposium on Healthy Aging – How to Age with Finesse, P35, 3/2013.

GUO R., Xiao J., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H., Lin B. and Tipoe G.L., The iron-chelating drug M30 down-regulates carbon tetrachloride (CCl4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro, 23^rd Conference of the Asian Pacific Association for the Study of Liver (APASL), Singapore, 6/2013. (Hepatology International 7: S37, 2013). 2013.

Researcher : Young W

List of Research Outputs

郑爽., 陈有.和., So K.F. and Young W., 中国脊髓损伤研究协作組(ChinaSCINet): 脊髓损竻临床试验阕络, 双清沦坛2012年10月13-14曰中国, 2012, 81: 12-13.

Researcher : ZHU D

List of Research Outputs

ZHU D., Yip Y.L., Deng W., Tsang C.M., Cheung A. and Tsao G.S.W., The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells, American Association of Cancer Research. 2013.

Researcher : Zhang E

List of Research Outputs

Chang R.C.C., Ho Y.S., Chiu K., Wong T.H.G., Wuwongse S., Tsang A.W.-.T., Lau W.M., Zhang E., Law A.C.K. and So K.F., Investigation of Wolfberry (the fruit of Lycium barbarum) as therapeutic and preventive medicine in Alzheimer's disease and glaucoma, 3rd International NeuroMalaysia Symposium. 2012, 8-9.

Yau S.Y., Lau W.M., Zhang E., Lee J.C.D., Li A., Lee T.M.C., Ching Y.P., Xu A. and So K.F., Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats, Neuroscience. Elsevier, 2012, 222: 289-301.

Zhang E., Yau S.Y., Lau W.M., Ma C.H.S., Lee T.M.C., Chang R.C.C. and So K.F., Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats, Cell Transplantation. 2012, 21: 2635-2649.

Researcher : Zhang G

List of Research Outputs

Zhang G., Tsang C.M., Deng W., Yip Y.L., Lui V.W., Wong S.C., Cheung A., Hau P.M., Zeng M., Lung M.L., Chen H., Lo K.W., Takada K. and Tsao G.S.W., Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells., PLoS One. 2013, 8: e62284.

Researcher : Zhang Q

List of Research Outputs

Chang R.C.C., Hung C.H.L., Zhang Q. and Ho Y.S., Characterizing the morphological changes and dynamic of mitochondria in neurons after exposure to ß-amyloid peptide., The 11th International Conference on Alzheimer's Disease / Parkinson's Disease. Florence, Italy. 2013.

Chang R.C.C., Hung H.L., Wuwongse S., Zhang Q. and Ho Y.S., Early dynamic changes of mitochondrial morphology in hippocampal neurons in response to beta-amyloid, Society for Neuroscience. 2012, 220.13.

Chang R.C.C., Zhang Q., Hung H.L., Wuwongse S. and Ho Y.S., Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide, Alzheimer's & Dementia. 2012, 8 (4) Supplment: 252-253.

Researcher : Zhang X

List of Research Outputs

Zhang X., Yeung P.K.K., McAlonan G.M., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion, Neurobiology of Learning and Memory. 2013, 101: 46-54.

Researcher : Zhou L

List of Research Outputs

Zhou L. and Chung S.K., Epac1 is involved in modulating hyperalgesic response to noxious inflammatory stimulus., The 16th Research Postgraduate Symposium. 2012.

Researcher : Zhou Y

List of Research Outputs

Mak W.Y.G., Lai W.L., Zhou Y., Li M., Ng I.O.L. and Ching Y.P., CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells, PLOS ONE. 2012, 7(7), pp: e42210.

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