Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au Yeung KHR

Project Title:	Identification of tumor suppressor receptor-type protein tyrosine phosphatases (R-PTPases) in nasal-type NK/T-cell lymphoma, and evaluation of their role as novel prognostic indicators and drug targets
Investigator(s):	Au Yeung KHR, Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	The role of SOX9 in mature B and T cell lymphomas
Investigator(s):	Au Yeung KHR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chan S.Y., Au Yeung K.H.R., Chim J.C.S., Wong C.Y. and Kwong Y.L., Disseminated fusarium infection after ibrutinib therapy in chronic lymphocytic leukaemia, Annals of Hematology. 2017, 96: 871-872.

Kwong Y.L., Chan S.Y.T., Tan D., Kim S.J., Poon L.M., Mow B., Khong P.L., Loong F., Au Yeung K.H.R., Iqbal J., Phipps C. and Tse E.W.C., PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase, Blood. 2017, 129: 2437-2442.

McKinney M., Moffitt A.B., Gaulard P., Travert M., De Leval L., Nicolae A., Raffeld M., Jaffe E.S., Pittaluga S., Xi L., Heavican T., Iqbal J., Belhadj K., Delfau-Larue M.H., Fataccioli V., Czader M.B., Lossos I.S., Chapman-Fredricks J.R., Richards K.L., Fedoriw Y., Ondrejka S.L., Hsi E.D., Low L., Weisenburger D., Chan W.C., Mehta-Shah N., Horwitz S., Bernal-Mizrachi L., Flowers C.R., Beaven A.W., Parihar M., Baseggio L., Parrens M., Moreau A., Sujobert P., Pilichowska M., Evens A.M., Chadburn A., Au Yeung K.H.R., Srivastava G., Choi W.L., Goodlad J.R., Aurer I., Basic-Kinda S., Gascoyne R.D., Davis N.S., Li G., Zhang J., Rajagopalan D., Reddy A., Love C., Levy S., Zhuang Y., Datta J., Dunson D.B. and Davé S.S., The Genetic Basis of Hepatosplenic T-cell Lymphoma, Cancer Discovery. 2017, 7: 369-379.

Moffittt A.B., Ondrejka S.L., McKinney M., Rempel R.E., Goodlad J.R., Teh C.H., Leppa S., Mannisto S., Kovanen P.E., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Iqbal J., Yu J., Naresh K., Villa D., Gascoyne R.D., Said J., Czader M.B., Chadburn A., Richards K.L., Rajagopalan D., Davis N.S., Smith E.C., Palus B.C., Tzeng T.J., Healy J.A., Lugar P.L., Datta J., Love C., Levy S., Dunson D.B., Zhuang Y., Hsi E.D. and Dave S.S., Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2, The Journal of Experimental Medicine. 2017, 214: 1371-1386.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Beh S.L., Defending Cases, Annual Conference Of African Society Of Forensic Medicine. 2017.

Beh S.L., Homicide-suicide In Hong Kong, Annual Meeting Of The African Society Of Forensic Medicine. 2017.

Beh S.L., Washing Away Of Wrongs - Forensic History, Annual Conference Of African Society Of Forensic Medicine. 2017.

Yip P.S.F., Cheng Q., Chang S.S., Lee E.S.T., Lai C.S., Chen F., Law Y.W., Cheng T.M., Chiu S.M., Tse M.L., Cheung K.R., Tse M.L., Morgan P.R. and Beh S.L., A Public Health Approach in Responding to the Spread of Helium Suicide in Hong Kong, Crisis. 2017, 1-9.

Researcher : CHAN KS

List of Research Outputs

Lo C.L.R., Leung O.N., CHAN K.S., Lee K.W. and Ng I.O.L., Cripto-1 activates the Wnt/β-catenin pathway and endows stemness properties in hepatocellular carcinoma, Digestive Disease Week 2017.

Researcher : CHAN YK

List of Research Outputs

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : CHIU KC

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Chan ASY

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Chan D

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Researcher : Chan GSW

List of Research Outputs

Chen J.Y., Chan G.S.W., Tsang J.P.Y. and Tsang K.F., The hospital mortuary: learning about death...and life, Medical Education. 2016.

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Mok M.Y., Chan G.S.W., Chan G.C.W., Ma K.M.M., Choy C.B.Y. and Chan D.T.M., Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant, Nephrology. 2016, 21(11): 980-981.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : Chan KK

Project Title:	iASPP and autophagy - novel molecular targets for ovarian clear cell carcinoma
Investigator(s):	Chan KK, Cheung ANY, Wong GW, Chan KKL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	06/2017

List of Research Outputs

Chan K.K., Wong G.W. and Cheung A.N.Y., Regulation on the gene expressions of ASPP family members, In: KK Chan, Oscar GW Wong and Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4th-6th December, 2016.

Wong G.W., Cheung L.Y., Chan K.K., Ip P.C.P. and Cheung A.N.Y., Impact of amyloid beta precursor protein gene APP overexpression on the cell growth and migration/invasion of Down syndrome trophoblast, In: Oscar GW Wong, Claire LY Cheung, KK Chan, Philip Ip, Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4-6 December 2016, Hong Kong. 2016.

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Investigator(s):	Chan KW, Ma SKY, Law SYK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	10/2016

Project Title:	A new tumor suppressor gene KIF7 inhibits tumor progression by suppressing Wnt/beta-catenin signaling in prostate cancer
Investigator(s):	Chan KW, Liu J
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	08/2016

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Cheung A., Li B., Xu W., Liu J. and Chan K.W., miR-29c modulates chemoresistance in esophageal cancer cells by suppressing FBXO31, European Journal of Cancer (24th Biennial Congress of the European Association for Cancer Research). 2016, 61 Suppl 1: S64.

Cheung K.F., Yung S.S.Y., Chau K.M., Yap Y.H.D., Chan K.W., Lee C.K., Tang S.O.C. and Chan D.T.M., Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations, Clinical Science. 2017, 131: 653-671.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Gopalan V., Islam F., Pillai S., Tang J.C.O., Tong K.H.D., Law S.Y.K., Chan K.W. and Lam A.K.Y., Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma, Experimental Cell Research. 2016, 348(2): 146-154.

Islam F., Gopalan V., Law S.Y.K., Tang J.C.O., Chan K.W. and Lam A.K.Y., MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions, Human Pathology. 2017, 62: 141-151.

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Li J., Zhang B.Z., Qin Y.R., Bi J., Liu H.B., Li Y., Ma S.K.Y., Chan K.W., Xie D. and Guan X., CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction, Oncotarget. 2016, 7: 15525-38.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

ZHENG H., Dai W., Cheung A.K.L., Ko J.M.Y., KAN P.Q.R., Wong W.Y., LEONG M.L., DENG M., Kwok C.T.T., Chan Y.W., Kwong D.L.W., Lee W.M.A., Ng W.T., Ngan R.K.C., Yau C.C., Tung S., Lee V.H.F., Lam K.O., Kwan C.K., Li W.S., Yau S., Chan K.W. and Lung M.L., Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kB pathway regulators in nasopharyngeal carcinoma, Proc Natl Acad Sci. 2016.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan LC

List of Research Outputs

Chen J.Y., Tsang C.O.A. and Chan L.C., Fostering Reflection-in-Action through a Performance Arts Workshop, In: Peterkin A and Brett-MacLean P , Keeping Reflection Fresh: A Practical Guide for Clinical Educators. . Kent University Press, 2016.

Wong R.S.C., Wong P.Y., Chen J.Y. and Chan L.C., Reflective space: The medical library as a mindfulness sanctuary, In: Allan Peterkin Pamela Brett-MacLean, Keeping Reflection Fresh: A Practical Guide for Clinical Educators. Kent University Press, 2016.

Researcher : Chan LK

List of Research Outputs

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Ho D.W.H., Lo C.L.R., Chan L.K. and Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, Liver Cancer. Karger, 2016, 5: 290-302.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2012

Researcher : Chan YF

List of Research Outputs

Lam Y.M., Chan Y.F., Chan L.C. and Ng R.K., Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo, International journal of hematology. 2017, 105: 37-43.

Researcher : Chan YK

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2010

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Placental biology of Down Syndrome in relation to increased gene dosage
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	p53 related proteins and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	NANOG and chemoresistance of ovarian cancer-initiating cells
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2015

Project Title:	Nanog in ovarian cancer metabolism
Investigator(s):	Cheung ANY, Chan KK, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Molecular targets of Stem cell factor NANOG in stress responses of ovarian cancer
Investigator(s):	Cheung ANY, Wong GW, Chan KK
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	p21 activated kinase 4 and ovarian cancer chemoresistance
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Oxidative phosphorylation in ovarian carcinoma and its effect on cancer stemness
Investigator(s):	Cheung ANY, Chan KK, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Chan K.K., Wong G.W. and Cheung A.N.Y., Regulation on the gene expressions of ASPP family members, In: KK Chan, Oscar GW Wong and Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4th-6th December, 2016.

Cheung A.N.Y., Autophagy and Ovarian Cancer, Invited speaker in 4th Meeting of International Ovarian Cancer Consortium in conjunction with the International Symposium on Tumor Microenvironment and Therapy Resistance, organized by the Seoul National University Hospital in Republic of Korea, February 23-25, 2017. 2017.

Cheung A.N.Y., Clinical Applications of Molecular Technologies in Gynaecological Diseases, Invited speaker in 首届海峡两岸精准医学国际高峰论坛 organized by the Cross Straits Association of Precision Medicine, Fuzhou, Nov 4-6, 2016. 2016.

Cheung A.N.Y., Cytology and HPV tests – Yin and Yang in Cervical Cancer Screening, Invited speaker in 2nd ICGEB Workshop on “Human papillomavirus: From Basic Biology to Cancer Prevention” organized by the Chinese University of Hong Kong, 8- 10 Nov 2016, Hong Kong. 2016.

Cheung A.N.Y., Evolution of Cervical Cancer Screening – New Horizon, Invited speaker in the Indonesian Society of Cervical Pathology Colposcopy Congress, Jakarta, April 12-13, 2017. 2017.

Cheung A.N.Y., Impact of psychosocial issues on cervical cancer prevention among Chinese women in Hong Kong, Invited speaker in 16th International Federation for Cervical Pathology and Colposcopy (IFCPC) World Congress organized by hosted by American Society of Colposcopy and Cervical Pathology (ASCCP) April 4-7, Orlando, FL, USA. 2017.

Cheung A.N.Y., Invasive and in situ glandular lesions of the lower female genital tract: microscope and DNA, Invited speaker in the 3rd Conference of Chinese Society for Colposcopy and Cervical Pathology 18th ‐21st May 2017, Beijing. 2017.

Cheung A.N.Y., Journal of Ovarian Research. 2017.

Cheung A.N.Y., Nuclei acid and Cells: Yin and Yang, Invited speaker in Asia Oceania (research organisation on) Genital Infections & Neoplasia (AOGIN), 12-14th August 2016 Singapore. 2016.

Cheung A.N.Y., Ovarian clear cell carcinoma, Invited speaker in International Congress of Gynecologic and Obstetric Pathology - Current Advances in Gynecologic Pathology and Women’s Health, organized by the International Society of Gynecological Pathologists and the Chinese Division- International Academy of Pathology, October 29-30th 2016. 2016.

Chow K.L., Tse K.Y., Cheung C.L., Wong K.W., Cheung A.N.Y., Wong W.C., Chan A.N.H., Yuen N.W.F., Ngan H.Y.S. and Ip P.C.P., The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study, Histopathology. United Kingdom, Wiley, 2017, 70: 746-755.

JIANG Y., Siu K.Y., WANG J., Leung T.H.Y., Ngan H.Y.S., Cheung A.N.Y. and Chan K.K.L., Hexokinase II (HK2) regulates stemness of ovarian cancer cells, AACR Annual Meeting 2017.

Kenigsberg S., Lima P.D., Maghen L., Wyse B.A., Lackan C., Cheung A.N.Y., Tsang B.K., Librach C.L. and Asselin E., The elusive MAESTRO gene: Its human reproductive tissue-specific expression pattern, PLOS ONE. 2017, 12: e0174873.

Liu S., Chu K.H., Wei N., Lau S.K., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Circulating micro-RNAs as biomarkers for detection of cervical cancer, International Papillomavirus Conference. 2017.

Tse K.Y., Lau S.K., Lui M.W., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Patient compliance with cervical smear surveillance in a shared-care setting, International Journal of Gynecology & Obstetrics. 2016.

WANG J., Siu K.Y., JIANG Y., Leung T.H.Y., Ngan H.Y.S., Cheung A.N.Y. and Chan K.K.L., PFKP and PFKFB3 modulate cancer metabolic switch and chemoresistance to cisplatin in ovarian cancer, AACR Annual Meeting 2017.

Wang A.S.Y., Tse K.Y., Wong G.W., Cheung A.N.Y. and Ip P.C.P., Expression of napsin A in Arias Stella reaction: an analysis of 40 cases, 2017 United States & Canadian Academy of Pathology Annual Meeting (Modern Pathology). 2017, 30: 314A.

Wong G.W., Cheung L.Y., Chan K.K., Ip P.C.P. and Cheung A.N.Y., Impact of amyloid beta precursor protein gene APP overexpression on the cell growth and migration/invasion of Down syndrome trophoblast, In: Oscar GW Wong, Claire LY Cheung, KK Chan, Philip Ip, Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4-6 December 2016, Hong Kong. 2016.

Researcher : Cheung LY

List of Research Outputs

Wong G.W., Cheung L.Y., Chan K.K., Ip P.C.P. and Cheung A.N.Y., Impact of amyloid beta precursor protein gene APP overexpression on the cell growth and migration/invasion of Down syndrome trophoblast, In: Oscar GW Wong, Claire LY Cheung, KK Chan, Philip Ip, Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4-6 December 2016, Hong Kong. 2016.

Researcher : Cheung YN

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2010

Researcher : Ching HH

List of Research Outputs

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP, Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The therapeutic potential of Polo-like protein kinase 4 in liver cancer
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015
Completion Date:	03/2017

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Characterization of novel HBx regulated gene in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Researcher : Chiu KC

List of Research Outputs

Researcher : Chiu YT

Project Title:	Analysis of hepatitis B virus genomic integration and characterization of its role in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL, Ho DWH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	10/2016

List of Research Outputs

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

Researcher : Choi WL

Project Title:	Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):	Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:	Pathology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	04/2011

List of Research Outputs

McKinney M., Moffitt A.B., Gaulard P., Travert M., De Leval L., Nicolae A., Raffeld M., Jaffe E.S., Pittaluga S., Xi L., Heavican T., Iqbal J., Belhadj K., Delfau-Larue M.H., Fataccioli V., Czader M.B., Lossos I.S., Chapman-Fredricks J.R., Richards K.L., Fedoriw Y., Ondrejka S.L., Hsi E.D., Low L., Weisenburger D., Chan W.C., Mehta-Shah N., Horwitz S., Bernal-Mizrachi L., Flowers C.R., Beaven A.W., Parihar M., Baseggio L., Parrens M., Moreau A., Sujobert P., Pilichowska M., Evens A.M., Chadburn A., Au Yeung K.H.R., Srivastava G., Choi W.L., Goodlad J.R., Aurer I., Basic-Kinda S., Gascoyne R.D., Davis N.S., Li G., Zhang J., Rajagopalan D., Reddy A., Love C., Levy S., Zhuang Y., Datta J., Dunson D.B. and Davé S.S., The Genetic Basis of Hepatosplenic T-cell Lymphoma, Cancer Discovery. 2017, 7: 369-379.

Researcher : Cui C

List of Research Outputs

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Researcher : GAO X

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Researcher : Ho DWH

Project Title:	Investigation of functional synergism of CENPF and FOXM1 in hepatocellular carcinoma
Investigator(s):	Ho DWH, Ng IOL, Chan LK, Kai AKL, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Ho D.W.H., Cancer genetics - the case of hepatocellular carcinoma, Basic research skills seminar, Center for Genomic Sciences, HKU. 2017.

Ho D.W.H., Frequent TERT genomic alterations in HBV-associated HCC and elucidation of novel mechanisms, State Key Laboratory for Liver Research Internal Research Meeting 2017. 2017.

Ho D.W.H., Lo C.L.R., Chan L.K. and Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, Liver Cancer. Karger, 2016, 5: 290-302.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Researcher : Ho RSL

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Huang F

Project Title:	In vivo tracking & visualizing the IL-10-producing regulatory B cells induced & expanded by IL-33 (BregIL-33), & following adoptive transfer of the BregIL-33 into IL-10-deficient mice
Investigator(s):	Huang F
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	07/2017

List of Research Outputs

Huang F., In: Fang-Ping Huang, Autoimmuno-Anti-Tumour Immunity (AATI) – Understanding the Immune Responses against “Self” & “Altered-self”. Lausanne Switzerland, Frontiers Media SA, 2017, 1-176.

Researcher : Ip HW

List of Research Outputs

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Singh G.H.H., Ip H.W., Yip S.F., Kho C.S.B., Lee K.K.H., Mak V., Lau J.S.M., Lau C.K., Lin S.Y., Wong S.M.R., Wa L.I. and Kwong Y.L., Clofarabine, Cytarabine And Mitoxantrone (CLAM) for relapsed or refractory acute myeloid leukaemia - interim results of a prospective phase 2 study, 22nd Congress of the European Haematology Association. 2017.

Researcher : Ip PCP

Project Title:	CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS
Investigator(s):	Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Role of MAPK7 signaling in endometrial carcinomas
Investigator(s):	Ip PCP, Cheung ANY, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2017

Project Title:	2017 United States & Canadian Academy of Pathology Annual Meeting; Expression of napsin A in Arias Stella reaction: an analysis of 40 cases
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017
Completion Date:	03/2017

Project Title:	Pathogenetic mechanisms of female genital tract malignant melanoma
Investigator(s):	Ip PCP, Tsang TY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

List of Research Outputs

Chow K.L., Tse K.Y., Cheung C.L., Wong K.W., Cheung A.N.Y., Wong W.C., Chan A.N.H., Yuen N.W.F., Ngan H.Y.S. and Ip P.C.P., The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study, Histopathology. United Kingdom, Wiley, 2017, 70: 746-755.

Ip P.C.P., An update on cervical glandular neoplasia, 25th Asian and Oceanic Congress of Obstetrics and Gynaecology (AOCOG), Hong Kong, 15-18 June 2017. 2017.

Ip P.C.P., Benign endometrial proliferations mimicking malignancies, XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology 2016, Cologne, Germany (26th September 2016). 2016.

Ip P.C.P., UPDATES ON PATHOLOGY OF UTERINE SMOOTH MUSCLE TUMORS: PRACTICAL ISSUES IN DAILY PRACTICE, 2017妇产科病理新进展研讨会及疑难病例读片 , HKU ShenZhen Hospital. 平滑肌肿瘤的病理学最新进展, 2017.

Ip P.C.P., Vulval Intraepithelial neoplasia, AOGIN 2016 – Asia-Oceania Research Organization in Genital Infection and Neoplasia congress that will be held in Singapore 12-14 August 2016. 2016.

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B., Cullaro G., CHONG C.K., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B, Journal of Hepatology. 2016, 66(2): 275-81.

Ngu S.F., Chu M.Y.M., Ip P.C.P. and Ngan H.Y.S., Vulvar Hidradenitis Suppurativa: Is the Mass Malignant? , J Obstet Gynaecol Can.. 2017.

See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017.

Tse K.Y., Lau S.K., Lui M.W., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Patient compliance with cervical smear surveillance in a shared-care setting, International Journal of Gynecology & Obstetrics. 2016.

Wang A.S.Y., Tse K.Y., Wong G.W., Cheung A.N.Y. and Ip P.C.P., Expression of napsin A in Arias Stella reaction: an analysis of 40 cases, 2017 United States & Canadian Academy of Pathology Annual Meeting (Modern Pathology). 2017, 30: 314A.

Wong G.W., Cheung L.Y., Chan K.K., Ip P.C.P. and Cheung A.N.Y., Impact of amyloid beta precursor protein gene APP overexpression on the cell growth and migration/invasion of Down syndrome trophoblast, In: Oscar GW Wong, Claire LY Cheung, KK Chan, Philip Ip, Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4-6 December 2016, Hong Kong. 2016.

Researcher : Ip PPC

Project Title:	CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS
Investigator(s):	Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Role of MAPK7 signaling in endometrial carcinomas
Investigator(s):	Ip PCP, Cheung ANY, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2017

Project Title:	2017 United States & Canadian Academy of Pathology Annual Meeting; Expression of napsin A in Arias Stella reaction: an analysis of 40 cases
Investigator(s):	Ip PCP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017
Completion Date:	03/2017

Project Title:	Pathogenetic mechanisms of female genital tract malignant melanoma
Investigator(s):	Ip PCP, Tsang TY
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

List of Research Outputs

Researcher : Kai AKL

List of Research Outputs

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

Researcher : Kan NCA

List of Research Outputs

Sun S., Kiang K.M.Y., Ho S.W.A., Lee D., Poon M.W., Xu F.F., Pu K.S.J., Kan N.C.A., Lee N.P.Y., Liu X., Man K., Day P.J.R., Lui W.M., Fung C.F. and Leung G.K.K., Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling, Oncotarget. 2017, Epub on 2017-05-19.

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):	Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Role of eIF4E in tamoxifen resistance in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals
Investigator(s):	Khoo US, Leung TW, Luk MY, Yeung MWR
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2013

Project Title:	The regulatory effect of a novel splice variant, BQ323636.1, on ERα transcriptional activity facilitates the development of tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Tang MKP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	The role of BQ, a novel splice variant of NCOR2 in the NRF2 antioxidant pathway
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	07/2015

Project Title:	Characterization of a Novel Splice Variant in Tamoxifen Resistant Breast Cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

Project Title:	Cardiac pacemaker channels modulating autophagy, cell senescence and apoptosis in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Testing Ivabradine on Patient Derived Xenografts: A Novel Potential Targeted Treatment for Breast Cancer
Investigator(s):	Khoo US, Tsoi H, Kwong A, Siu DCW
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	02/2017

Project Title:	Identifying Splicosome gene alterations associated with Tamoxifen resistance in Breast Cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target.
Investigator(s):	Khoo US, Tsoi H
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

Project Title:	WIN 2017 Symposium: Expediting Global Innovation in Precision Cancer Medicine; A Novel Splice Variant to NCOR2 as Biomarker for Tamoxifen Resistant Breast Cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

Chan L.K., Wong F.K.Y., Ganotice F.J.A., Lau W.C.S., Lam T.P., Bridges S.M., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Chin W.Y., Harbutt D., Khoo U.S., Lam S.F., Lao L., Leung G.K.K. and Li Q., Bronze in Discipline Award (Life Sciences), in Quacquarelli Symonds (QS) Reimagine Education competition: Interprofessional Team-Based Learning for Health Professional Students, Quacquarelli Symonds. 2016.

Gong C., Man P.S., Lee T.K.W., Tsoi H., Wong L.S., Luk M.Y., Rakha E.A., Lam E.W.F., Green A.R., Cheung K.L. and Khoo U.S., A Novel Splice Variant to NCOR2 as Biomarker for Tamoxifen Resistant Breast Cancer, Worldwide Innovation Networking in Personalized Cancer Medicine (WIN 9th Symposium, Expediting Global Innovation in Precision Cancer Medicine), Paris. 2017.

Khoo U.S., Genetic Susceptibility to Breast and Ovarian Cancer, Advances in Cancer Genetics Cell Signaling and Translational Studies, Hong Kong. 2016.

Kongsema M., Zona S., Karunarathna U., Cabrera E., Man P.S., Yao S., Shibakawa A., Khoo U.S., Medema R.H., Freire R. and Lam E.W., RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment, Oncogenesis. 2016, 5(8): e252.

Researcher : Ko FCF

Project Title:	Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	24th Biennial Congress of the European Association fro Cancer Research (EACR); Functional characterization of novel tumour suppressor galectin-2 in hepatocellular carcinoma
Investigator(s):	Ko FCF
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Ko F.C.F., Lee K.W., Tai W.C.S., LEUNG Z. and Yam J.W.P., Functional characterization of novel tumour suppressor galectin-2 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

LEUNG Z., Ko F.C.F. and Yam J.W.P., Clinical relevance and functional role of galectin-1 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Researcher : Koh HY

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Researcher : Kwok JSY

List of Research Outputs

Kwok J.S.Y., Choi L.C.W., Ho J.C.Y., Chan G.S.W., Mok M.Y., Lam M.F., Chak W.L., Cheuk A., Chau K.F., Tong K.L., Chan K.W. and Chan D.T.M., A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients, PLOS ONE. 2016, 11(11): e0166427.

Kwok J.S.Y., GUO M., Yang W., Lee C.K., Chan N.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry, Human Immunology. 2016, 77: 1109-1110.

Kwok J.S.Y., GUO M., Yang W., Lee C.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals, Human Immunology. ELSEVIER, 2016, 77: 1111-1112.

Mok M.Y., Ma K.M.M., Yap Y.H.D., Chan G.S.W., Lam M.F., Kwok J.S.Y., Kwan P.Y.L., Chan G.C.W., Choy C.B.Y., Tang S.C.W. and Chan D.T.M., Risk factors and prognosis of late acute rejection in Chinese kidney transplant recipients, Nephrology. 2016.

Researcher : LAI KH

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : LAW CT

List of Research Outputs

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : LEE D

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : LEUNG Z

List of Research Outputs

Ko F.C.F., Lee K.W., Tai W.C.S., LEUNG Z. and Yam J.W.P., Functional characterization of novel tumour suppressor galectin-2 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

LEUNG Z., Ko F.C.F. and Yam J.W.P., Clinical relevance and functional role of galectin-1 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Researcher : LIU HM

List of Research Outputs

LIU H.M., Tey S.K. and Yam J.W.P., Rab20 and Rab30 regulate hepatocellular carcinoma (HCC) for tumor suppression, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Researcher : Lai CWJ

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Lai JCC

Project Title:	Comparison of native influenza virus and virus-like-particles in their receptor-binding properties
Investigator(s):	Lai JCC, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Hui P.Y., Chan L.Y., Kuok I.T., Mok K.P., Yang Z.F., Li R.F., Luk G.S., Lee E.F., Lai J.C.C., Yen H., Zhu H., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex vivo and in vitro cultures of the human respiratory tract, European Respiratory Journal. 2017, 49: 1601710.

Lin Y.P., Yang Z.F., Liang Y., Li Z.T., Bond H.D., Chua H.Y., Luo Y.S., Chen Y., Chen T.T., Guan W.D., Lai J.C.C., Siu Y.L., Pan S.H., Peiris J.S.M., Cowling B.J. and Mok K.P., Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China, BMC Infectious Diseases. 2016, 16(1): 632.

Researcher : Lai KH

List of Research Outputs

Researcher : Lam AKY

List of Research Outputs

CHAI W.Y., Cheung A.K.L., Dai W., Ko J.M.Y., Ip J.C.Y., Chan K.W., Kwong D.L.W., Ng W.T., Lee W.M.A., Ngan K.C., Yau C.C., Tung S.Y., Lee V.H.F., Lam A.K.Y., Pillai S., Law S.Y.K. and Lung M.L., Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathologenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma, Oncotarget. 2016, 7(48): 78859-78871.

Gopalan V., Islam F., Pillai S., Tang J.C.O., Tong K.H.D., Law S.Y.K., Chan K.W. and Lam A.K.Y., Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma, Experimental Cell Research. 2016, 348(2): 146-154.

Islam F., Gopalan V., Law S.Y.K., Tang J.C.O., Chan K.W. and Lam A.K.Y., MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions, Human Pathology. 2017, 62: 141-151.

Pun I.H.Y., Chan D., Chan S.H., Chung P.Y., Zhou Y.Y., Law S.Y.K., Lam A.K.Y., Chui C.H., Chan A.S.C., Lam K.H. and Tang J.C.O., Anti-cancer effects of a novel quinoline derivative 83b1 on human esophageal squamous cell carcinoma through down-regulation of COX-2 mRNA and PGE2, Cancer Research and Treatment. 2017, 49(1): 219-229.

Researcher : Lam CW

Project Title:	The first prospective second generation newborn screening in Hong Kong
Investigator(s):	Lam CW, Chan AYW, Mak CM
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Food
Investigator(s):	Lam CW, Wang M
Department:	Pathology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Undiagnosed diseases program for ending diagnostic odyssey
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2014
Completion Date:	10/2017

Project Title:	Regulatory signatures of two novel prognostic metabotypes of lung adenocarcinomas: integrated analysis of transcriptomics and metabonomics of malignant pleural effusions
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	2016 ASHG Annula Meeting; Adenylate kinase 9 (AK9) mutation is a novel disease gene for congenital myasthenic syndrome with limb girdle myasthenia
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2016
Completion Date:	10/2016

Project Title:	Clinical application of pleural fluid fatty acid synthase and pleural fluid total free fatty acids as cancer biomarkers in malignant pleural effusions
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	06/2017

List of Research Outputs

Lam C.W., Methods for classifying pleural fluid , In: Ching-wan Lam, United States Patent and Trademark Office. 2017.

Siu C.W.K., Lam C.W., Mak C.M., Lau E.T.K., Tang M.H.Y., Tang W.F., Poon-Mak R.S., Lee C.C., Hung S.F., Leung P.W., Kwong K.L., Yau E.K., Ng G.S., Fong N.C. and Chan K.Y., Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong, Clinical and Translational Medicine. 2016, 5.

Researcher : Lau CF

List of Research Outputs

Hung M.W., Yeung H.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin attenuates pulmonary hypertension in chronically hypoxic rats, International Journal of Molecular Sciences. 2017, 18(6): 1125.

Researcher : Lau YT

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Researcher : Lee CH

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Researcher : Lee D

List of Research Outputs

Researcher : Lee KW

Project Title:	The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma
Investigator(s):	Lee KW, Ng IOL, Ma SKY
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	The roles of Nuclear factor (erythroid-derived 2)-like 2 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Ko F.C.F., Lee K.W., Tai W.C.S., LEUNG Z. and Yam J.W.P., Functional characterization of novel tumour suppressor galectin-2 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Lo C.L.R., Leung O.N., CHAN K.S., Lee K.W. and Ng I.O.L., Cripto-1 activates the Wnt/β-catenin pathway and endows stemness properties in hepatocellular carcinoma, Digestive Disease Week 2017.

Tang K.D., Liu J., Jovanovic L., An J., Hill M.M., Vela I., Lee K.W., Ma S.K.Y., Nelson C., Russell P.J., Clements J.A. and Ling M.T., Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop, Oncotarget. 2016, 7: 4939-48.

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Researcher : Lee MF

List of Research Outputs

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

Researcher : Leung ON

Project Title:	Epigenetic modulation of Sox9 in HCC
Investigator(s):	Leung ON, Lo CLR
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	12/2016

List of Research Outputs

Lo C.L.R., Leung O.N., CHAN K.S., Lee K.W. and Ng I.O.L., Cripto-1 activates the Wnt/β-catenin pathway and endows stemness properties in hepatocellular carcinoma, Digestive Disease Week 2017.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2005

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

Project Title:	Gastric cancer genomics and beyond – moving from patient samples to 3D organoid cultures for integrative genomics analysis, drug sensitivity assays, cell biological studies and animal models
Investigator(s):	Leung SY, Zhang J, Law SYK, Ma SKY, Kwong DLW, Chan D, Ching YP, Wong SL
Department:	Pathology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2016

Project Title:	Establishing Mass Spectrometer Based Targeted Metobolomics Platform for Biomarker Validation Studies as a Core Facility
Investigator(s):	Leung SY, Boheler KR, Cheung BMY, Cheung CL, Leung AYH, Ma SKY, Rong J, Sze KH, Woo PCY, Wong CCL, Xu A
Department:	Pathology
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

List of Research Outputs

Leung S.Y., Exome sequencing and integrative genomic analysis identified the important role of germline and somatic RNF43 mutation in the serrated neoplasia pathway, 2016 Micro-invasive technique, Bowel disease & Prevention and early diagnosis of colorectal neoplasm”, Beijing, China. 2016.

Leung S.Y., Exome sequencing and integrative genomic analysis identified the important role of germline and somatic RNF43 mutation in the serrated neoplasia pathway, The 11th International Conference on Genomics (ICG-11), China National Genebank, Shenzhen, China. 2016.

Leung S.Y., Germline and somatic mutation of RNF43 in the serrated neoplasia pathway, The 5th Hong Kong Pathology Forum, Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2017.

Leung S.Y., Korea Association of Medical Colleges Annual Conference, Suwon, South Korea, The Era of Convergence in Medicine : Mindset Changes and Adaptation for Practice and Research. 2016.

Leung S.Y., The 12th International Gastric Cancer Congress, Beijing, China, Gastric cancer genomics and beyond. 2016.

Leung S.Y., The 24th Asia Pacific Cancer Conference, Seoul, Korea, Cancer genomics of hereditary cancer - Exome sequencing and integrative genomic analysis identified the important role of germline and somatic RNF43 mutation in the serrated neoplasia pathway. 2017.

Leung S.Y., The Annual Meeting of Chinese Gastrointestinal Oncology Group 2017, Beijing, China, Application and Unsolved Questions of CTC/ctDNA/NGS/PDX in Gastric Cancer. 2017.

Swanton C., Soria J.C., Bardelli A., Biankin A., Caldas C., Chandarlapaty S., de Koning L., Dive C., Feunteun J., Leung S.Y., Marais R., Mardis E.R., McGranahan N., Middleton G., Quezada S.A., Rodón J., Rosenfeld N., Sotiriou C. and André F., Consensus on precision medicine for metastatic cancers: a report from the MAP conference: Table 1., Annals of Oncology. 2016, 27: 1443-1448.

Researcher : Leung TKC

List of Research Outputs

Surapolchai P., Chuansumrit A., Sirachainan N., Kadegasem P., Leung T.K.C. and So J.C.C., A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease, Annals of Hematology. 2017, 96: 1005-1014.

Researcher : Li LL

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Lin X

Project Title:	IMMUNOLOGY 2015™ AAI Annual Meeting; A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome
Investigator(s):	Lin X
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

List of Research Outputs

Lin X., Best Poster Presentation Award, 2016, The Hong Kong Society for Immunology. 2016.

Researcher : Lo CLR

Project Title:	Study of the role of Stanniocalcin 1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	Study of the clinical relevance and functional role of Stanniocalcin 1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Epigenetic regulation of Cripto-1 expression in hepatocellular carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Clinical relevance and functional characterization of Cripto-1 in conferring stemness properties of hepatocellular carcinoma
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2016

Project Title:	DDW 2017; Cripto-1 activates the Wnt/b-catenin pathway and endows stemness properties in hepatocellular carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

Project Title:	Delineation and validation of downstream targets of GATA6 in conferring stemness features of liver cancer
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Ho D.W.H., Lo C.L.R., Chan L.K. and Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, Liver Cancer. Karger, 2016, 5: 290-302.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

Liu A.P.Y., Ip J.J.K., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Outcome of Paediatric Hepatoblastoma in Hong Kong, SIOPEL Spring Meeting 2017.

Lo C.L.R., Clinical Research Fellowship, Research Grants Council, Hong Kong. 2016.

Lo C.L.R., Leung O.N., CHAN K.S., Lee K.W. and Ng I.O.L., Cripto-1 activates the Wnt/β-catenin pathway and endows stemness properties in hepatocellular carcinoma, Digestive Disease Week 2017.

Lo C.L.R., Graduate school course on Pancreaticobiliary Pathology, Seoul National University College of Medicine, Korea. 2016.

Lo C.L.R., Updates on the pathogenesis of hepatocellular carcinoma, Hong Kong Pathology Forum 2017. 2017.

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Researcher : Lo WIA

List of Research Outputs

Vardhanabhuti V., Lo W.I.A., Lee E.Y.P. and Law S.Y.K., Dual-Tracer PET/CT Using 18F-FDG and 11C-Acetate in Gastric Adenocarcinoma With Liver Metastasis, Clin Nucl Med. 2016.

Researcher : Loong F

List of Research Outputs

Chok K.S.H., Loong F. and Lo C.M., An extra-adrenal pheochromocytoma mimicking a primary liver cancer, Hepatoma Research. 2016, 2: 297-299.

Kwong Y.L., Chan S.Y.T., Tan D., Kim S.J., Poon L.M., Mow B., Khong P.L., Loong F., Au Yeung K.H.R., Iqbal J., Phipps C. and Tse E.W.C., PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase, Blood. 2017, 129: 2437-2442.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Leptin regulates plasma cell generation and survival in autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	B-1 cell response and its regulation during influenza virus infection
Investigator(s):	Lu L, Ko KH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	09/2016

Project Title:	Outstanding Researcher Award 2012-13
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2014

Project Title:	Role of B cells in the pulmonary anti-viral immune response
Investigator(s):	Lu L, Ma K
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Major Research Project
Start Date:	01/2015

Project Title:	The role of B1 cells in the development of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The Role of B cells in the development of experimental Sjogren's syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Functional characterization and therapeutic application of regulatory B cells in Sjögren’s syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016
Completion Date:	12/2016

Project Title:	Studies on the Pathogenesis and Treatment of Sjören’s Syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Croucher Foundation - Research Grants
Start Date:	01/2016

Project Title:	The Role of interleukin-17 in the pathogenesis of experimental Sjögren's syndrome
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	The role of B cells in the pathogenesis of lung fibrosis during influenza infection
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

Project Title:	8th European Immunology Conference; A critical role of leptin in promoting B cell response during the development of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

List of Research Outputs

Deng Y., Wang Z., Chang C., Lu L., Lau W.C.S. and Lu Q., Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials, Human Immunology. 2017, 78: 120-128.

Kwok J.S.Y., GUO M., Yang W., Lee C.K., Chan N.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry, Human Immunology. 2016, 77: 1109-1110.

Kwok J.S.Y., GUO M., Yang W., Lee C.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals, Human Immunology. ELSEVIER, 2016, 77: 1111-1112.

Lu L., Associate Editor-in-Chief (2017-2020), Cellular and Molecular Immunology . Nature Publishing Co., 2017.

Lu L., Frontiers in Immunology (Editor, 2017-2020), International Union of Immunological Societies, 2017.

Rui K., Tian J., Tang X., Ma J., Xu P., Tian X., Wang Y., Xu H., Lu L. and Wang S., Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden, Immunologic Research. 2016, 64: 931-939.

Yan S., Yim L.Y., Tam C.Y., Chan W.K., Lu L., Lau W.C.S. and Chan V.S.F., MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice, International Journal of Molecular Sciences. 2016, 17: 1282.

Researcher : Ma ESK

List of Research Outputs

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Researcher : Mak CM

List of Research Outputs

Siu C.W.K., Lam C.W., Mak C.M., Lau E.T.K., Tang M.H.Y., Tang W.F., Poon-Mak R.S., Lee C.C., Hung S.F., Leung P.W., Kwong K.L., Yau E.K., Ng G.S., Fong N.C. and Chan K.Y., Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong, Clinical and Translational Medicine. 2016, 5.

Researcher : Man PS

List of Research Outputs

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

Gong C., Man P.S., Lee T.K.W., Tsoi H., Wong L.S., Luk M.Y., Rakha E.A., Lam E.W.F., Green A.R., Cheung K.L. and Khoo U.S., A Novel Splice Variant to NCOR2 as Biomarker for Tamoxifen Resistant Breast Cancer, Worldwide Innovation Networking in Personalized Cancer Medicine (WIN 9th Symposium, Expediting Global Innovation in Precision Cancer Medicine), Paris. 2017.

Kongsema M., Zona S., Karunarathna U., Cabrera E., Man P.S., Yao S., Shibakawa A., Khoo U.S., Medema R.H., Freire R. and Lam E.W., RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment, Oncogenesis. 2016, 5(8): e252.

Researcher : Mao X

Project Title:	The role of mitochondria-targeted Heme Oxygenase-1 in liver cancer development and progression
Investigator(s):	Mao X, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	12/2016

List of Research Outputs

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Mao X., Guan X. and Yam J.W.P., Role of caveolin-1 in hepatitis B virus-induced hepatocarcinogenesis, Health Research Symposium 2017.

Tey S.K., Mao X. and Yam J.W.P., Exosome Released from Nuclear Met Expressing Cells Promote Liver Cancer Metastasis and Formation of Lung Prematastatic Niche, The Liver Week 2017.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL, Tung KK
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2011

Project Title:	Cancer Biology
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Croucher Summer Courses
Start Date:	08/2013

Project Title:	The role of Lgr5 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Delineation of the role of RPS6KA3, which encodes p90 ribosomal S6 kinase 2 (RPS6KA3), and their natural mutants in liver cancer
Investigator(s):	Ng IOL, Chan LK, Chiu YT, Ho DWH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015
Completion Date:	10/2017

Project Title:	Characterization of functions of RhoE/ROCK pathway in regulating chemoresistance of liver cancer
Investigator(s):	Ng IOL, Ma W
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	The role of SUMO-specific protease SENP1 in liver cancer
Investigator(s):	Ng IOL, Wong CCL, Cui C
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Characterization of anti-CCL28 as a novel therapy to overcome sorafenib resistance in HCC
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Role of RalA and RalGAP in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Understanding Cancer Stemness in Liver Cancer – From Regulation to Translational Applications
Investigator(s):	Ng IOL, Guan X, Sham PC, Wong CCL, Ching YP, Jin D, Ma SKY, Mak TW, Wong CM, Poon RTP, Yau TCC, Cheung TT
Department:	Pathology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2017

Project Title:	The role of RalA GTPase and its regulator RalGAP in liver cancer
Investigator(s):	Ng IOL, Chan LK, Ho DWH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	American Association for Cancer Research Annual Meeting; TSC1/2 mutations define a molecular subset of HCC with aggressive behavior and treatment implication
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment
Investigator(s):	Ng IOL, Wong CCL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	The role of hypoxia-induced ephrinA3-ephrin receptor signaling in liver cancer
Investigator(s):	Ng IOL, Chiu YT
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Ho D.W.H., Lo C.L.R., Chan L.K. and Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, Liver Cancer. Karger, 2016, 5: 290-302.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Lo C.L.R., Leung O.N., CHAN K.S., Lee K.W. and Ng I.O.L., Cripto-1 activates the Wnt/β-catenin pathway and endows stemness properties in hepatocellular carcinoma, Digestive Disease Week 2017.

Ma K.W., Cheung T.T., She W.H., Chok K.S.H., Chan A.C.Y., Ng I.O.L., Chan S.C. and Lo C.M., The effect of wide resection margin in patients with intrahepatic cholangiocarcinoma: a single-center experience, Medicine (Baltimore). 2016, 95(28): e4133.

Ma K.W., Cheung T.T., She W.H., Chok K.S.H., Chan A.C.Y., Ng I.O.L., Chan S.C., Lo C.M. and Poon R.T.P., Wide resection margin improves survival in patients with early intrahepatic cholangiocarcinoma – a 22-year single center experience, The 7th Asia-Pacific Primary Liver Cancer Expert Meeting, Hong Kong, 8-10 July 2016. Liver Cancer. 2016, 5(Suppl. 1): 73.

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Ng I.O.L., Asian Journal of Surgery. 2016.

Ng I.O.L., Asian Journal of Surgery. 2017.

Ng I.O.L., Fibrosis-dependent mechanism of hepatocarcinogenesis, State Key Lab for Liver Research (SKLLR), symposium 2016. 2016.

Ng I.O.L., Gastroenterology (International Consultant), 2017.

Ng I.O.L., Genes and Cancer, 2016.

Ng I.O.L., Genes and Cancer, 2017.

Ng I.O.L., Hepatology. 2017.

Ng I.O.L., Implications of liver cancer stem cells for a new therapeutic target, Asian Pacific Association for the Study of Liver meeting, Shanghai. 2017.

Ng I.O.L., Journal of Gastroenterology and Hepatology. 2017.

Ng I.O.L., Journal of Gastroenterology and Hepatology. 2016.

Ng I.O.L., Journal of Hepatocellular Carcinoma. 2017.

Ng I.O.L., Journal of Hepatocellular Carcinoma (Editorial Board). 2017.

Ng I.O.L., Journal of Hepatocellular Carcinoma (Editorial Board). 2016.

Ng I.O.L., Liver Cancer. 2016.

Ng I.O.L., Liver Cancer. 2017.

Ng I.O.L., Liver Cancer - beyond histopathology, Hong Kong Pathology Forum. 2017.

Ng I.O.L., New Targets in Hepatocellular Carcinoma – Liver Cancer Stem Cells, International Liver Cancer Association 10th Annual Meeting, Vancouver, Canada. 2016.

Ng I.O.L., Oncogenesis (Nature Partner Journal), 2017.

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Xu H.T., Lai W.L., Liu H.F., Wong L.L.Y., Ng I.O.L. and Ching Y.P., PAK4 phosphorylates p53 at serine 215 to promote liver cancer metastasis., Cancer Research. American Association for Cancer Research., 2016, 76: 5732-5742.

Researcher : Ng WF

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Molecular determinants of H9N2 virus haemagglutinin and neuraminidase affecting virus tropism for the human and swine respiratory tract
Investigator(s):	Nicholls JM, Chan WY, Mok KP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	Sialoglyco 2014; Glycomic Characterization of Respiratory Tract Tissues of Ferrets Shows Expression of Different Sialylatyed Glycans to Humans: Implications for the Use of Ferrets in Influenza Virus Infection Studies.
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014

Project Title:	Modulation of MERS-CoV infection of the human ex vivo respiratory tract by the use of interferon, cyclophilin inhibitors and blocking antibody therapy
Investigator(s):	Nicholls JM, Chan WY
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	The viral genetic determinants of influenza H5N1 virus in causing acute lung injury - an in vitro study
Investigator(s):	Nicholls JM, Chan MCW
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2015

List of Research Outputs

Chan L.Y., BUI H.T., Mok K.P., Ng M.M.T., Nicholls J.M., Peiris J.S.M., Chan M.C.W. and Chan W.Y., Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures, Scientific Reports. 2016, 6: 35401.

Chan L.Y., Nicholls J.M., Peiris J.S.M., Chan M.C.W. and Chan W.Y., Neutrophil Mediated Host Responses during Influenza A Virus Infection, An In Vitro Study, Health Research Symposium 2017.

Chan L.Y., Chan W.Y., Ng M.M.T., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Risk assessment on human transmission potential of avian influenza H7N9 virus using ex vivo cultures of the human respiratory tract, Options of Control of Influenza IX. 2016.

Hui P.Y., LI H.S., Cheung M.C., Chan R.W.Y., Yuen K.M., Mok K.P., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3, Options IX for The Control of Influenza . 2016.

Hui P.Y., Chan L.Y., Mok K.P., KUOK I.T., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tropism and innate host responses of a novel avian influenza A/H5N6 virus in ex vivo and in vitro models of the human respiratory tract, Options IX for the Control of Influenza. 2016.

Hui P.Y., Chan L.Y., Kuok I.T., Mok K.P., Yang Z.F., Li R.F., Luk G.S., Lee E.F., Lai J.C.C., Yen H., Zhu H., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex vivo and in vitro cultures of the human respiratory tract, European Respiratory Journal. 2017, 49: 1601710.

Researcher : Shek TWH

List of Research Outputs

Lang H.H.B., Shek T.W.H., Chan A.O., Lo C.Y. and Wan K.Y., Significance of size of persistent/recurrent central nodal disease on surgical morbidity and response to therapy in reoperative neck dissection for papillary thyroid carcinoma, Thyroid. 2016, Epub ahead of print.

Lang H.H.B., Shek T.W.H. and Wan K.Y., The significance of unrecognized histological high-risk features on response to therapy in papillary thyroid carcinoma measuring 1-4cm: implications for completion thyroidectomy following lobectomy, Clinical Endocrinology (Oxford). 2016, Epub ahead of print.

Lang H.H.B., Shek T.W.H., Wu L.H.A. and Wan K.Y., The total number of tissue blocks per centimetre of tumor significantly correlated with the risk of distant metastasis in patients with minimally invasive follicular thyroid carcinoma, Endocrine. 2016, 1-7.

Researcher : Siu CWK

List of Research Outputs

Siu C.W.K., Lam C.W., Mak C.M., Lau E.T.K., Tang M.H.Y., Tang W.F., Poon-Mak R.S., Lee C.C., Hung S.F., Leung P.W., Kwong K.L., Yau E.K., Ng G.S., Fong N.C. and Chan K.Y., Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong, Clinical and Translational Medicine. 2016, 5.

Researcher : Siu HC

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

Researcher : So JCC

List of Research Outputs

CHER C.Y., LEUNG G.M.K., AU C.H., CHAN T.L., MA E.S.K., Sim P.Y.J., Singh G.H.H., Lie A.K.W., Liang R.H.S., WONG K.F., SIU L.L.P., TSUI C.S.P., So J.C.C., WONG H.W.W., YIP S.F., LEE H.K.K., LIU H.S.Y., LAU J.S.M., LUK T.H., LAU T.K., LIN S.Y., Kwong Y.L. and Leung A.Y.H., Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome, Blood Cancer Journal. 2016, 6: e442.

Ip K.L., So J.C.C., Law M.F., Wong R.S., Tam H.C. and Ng M.H., Hb Tarrant [ α 126(H9)Asp→Asn; HBA2 : c.379G > A (or HBA1 )] in a Chinese Family as a Cause of Familial Erythrocytosis , Hemoglobin. 2016, 40: 260-263.

LAM S.Y., HO S.K., He B.A., Wong W.W., CHER C.Y., NG K.L., Man C.H., Singh G.H.H., Cheung A.M.S., Ip H.W., So J.C.C., Tamburini J., So C.W.E., Ho D.N., Au C.H., Chan T.L., Ma E.S.K., Liang R.H.S., Kwong Y.L. and Leung A.Y.H., Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia, Science Translational Medicine. 2016, 8: 359ra129-359ra129.

Surapolchai P., Chuansumrit A., Sirachainan N., Kadegasem P., Leung T.K.C. and So J.C.C., A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease, Annals of Hematology. 2017, 96: 1005-1014.

Researcher : Srivastava G

Project Title:	Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

List of Research Outputs

McKinney M., Moffitt A.B., Gaulard P., Travert M., De Leval L., Nicolae A., Raffeld M., Jaffe E.S., Pittaluga S., Xi L., Heavican T., Iqbal J., Belhadj K., Delfau-Larue M.H., Fataccioli V., Czader M.B., Lossos I.S., Chapman-Fredricks J.R., Richards K.L., Fedoriw Y., Ondrejka S.L., Hsi E.D., Low L., Weisenburger D., Chan W.C., Mehta-Shah N., Horwitz S., Bernal-Mizrachi L., Flowers C.R., Beaven A.W., Parihar M., Baseggio L., Parrens M., Moreau A., Sujobert P., Pilichowska M., Evens A.M., Chadburn A., Au Yeung K.H.R., Srivastava G., Choi W.L., Goodlad J.R., Aurer I., Basic-Kinda S., Gascoyne R.D., Davis N.S., Li G., Zhang J., Rajagopalan D., Reddy A., Love C., Levy S., Zhuang Y., Datta J., Dunson D.B. and Davé S.S., The Genetic Basis of Hepatosplenic T-cell Lymphoma, Cancer Discovery. 2017, 7: 369-379.

Moffittt A.B., Ondrejka S.L., McKinney M., Rempel R.E., Goodlad J.R., Teh C.H., Leppa S., Mannisto S., Kovanen P.E., Tse E.W.C., Au Yeung K.H.R., Kwong Y.L., Srivastava G., Iqbal J., Yu J., Naresh K., Villa D., Gascoyne R.D., Said J., Czader M.B., Chadburn A., Richards K.L., Rajagopalan D., Davis N.S., Smith E.C., Palus B.C., Tzeng T.J., Healy J.A., Lugar P.L., Datta J., Love C., Levy S., Dunson D.B., Zhuang Y., Hsi E.D. and Dave S.S., Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2, The Journal of Experimental Medicine. 2017, 214: 1371-1386.

Researcher : Sze MF

Project Title:	The characterizations of Ubiquitin-Conjugating Enzyme E2O (UBE2O) in mitotic checkpoint control via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

List of Research Outputs

Ching H.H., Sze M.F., Lau Y.T., Chiu Y.T., Lee M.F., Ng I.O.L. and Lee K.W., C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway, Oncotarget. 2017.

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Researcher : Tam S

List of Research Outputs

Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum Vitamin D concentration is independently associated with anti-Mullerian hormone level and obesity measures in Hong Kong Chinese women with polycystic ovary syndrome., The 17th International Congress of Endocrinology and the 15th Annual Meeting of the Chinese Society of Endocrinology. 2016.

Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Ho P.C. and Ng E.H.Y., Serum vitamin D concentration is independently associated with anti-Mullerian hormone and obesity measures in Hong Kong Chinese women with polycystic ovary syndrome, The 17th International Congress of Endocrinology and the 15th Annual Meeting of the Chinese Society of Endocrinology. 2016.

Researcher : Tang JCO

List of Research Outputs

Gopalan V., Islam F., Pillai S., Tang J.C.O., Tong K.H.D., Law S.Y.K., Chan K.W. and Lam A.K.Y., Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma, Experimental Cell Research. 2016, 348(2): 146-154.

Islam F., Gopalan V., Law S.Y.K., Tang J.C.O., Chan K.W. and Lam A.K.Y., MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions, Human Pathology. 2017, 62: 141-151.

Pun I.H.Y., Chan D., Chan S.H., Chung P.Y., Zhou Y.Y., Law S.Y.K., Lam A.K.Y., Chui C.H., Chan A.S.C., Lam K.H. and Tang J.C.O., Anti-cancer effects of a novel quinoline derivative 83b1 on human esophageal squamous cell carcinoma through down-regulation of COX-2 mRNA and PGE2, Cancer Research and Treatment. 2017, 49(1): 219-229.

Researcher : Tey SK

Project Title:	24th Biennial EACR Congress; Role of nuclear met-derived exosomes in hepatocellular carcinoma metastasis and lung premetastatic niche formation
Investigator(s):	Tey SK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

LIU H.M., Tey S.K. and Yam J.W.P., Rab20 and Rab30 regulate hepatocellular carcinoma (HCC) for tumor suppression, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Tey S.K., Mao X. and Yam J.W.P., Exosome Released from Nuclear Met Expressing Cells Promote Liver Cancer Metastasis and Formation of Lung Prematastatic Niche, The Liver Week 2017.

Tey S.K., Travel Award, The Liver Week 2017. 2017.

Researcher : Tsang FH

Project Title:	Functional characterization of Chromobox protein homolog 1 (CBX1) and delineation of its regulation by micro-RNA in hepatocellular carcinoma
Investigator(s):	Tsang FH, Wong CM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	American Association of Cancer Research (AACR) Annual Meeting 2017; Functional and mechanistic characterization of oncogenic long intervening non-coding RNA Linc-CHD1L-1 in hepatocellular carcinoma
Investigator(s):	Tsang FH
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Tse PW

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Tsoi H

List of Research Outputs

Gong C., Man P.S., Lee T.K.W., Tsoi H., Wong L.S., Luk M.Y., Rakha E.A., Lam E.W.F., Green A.R., Cheung K.L. and Khoo U.S., A Novel Splice Variant to NCOR2 as Biomarker for Tamoxifen Resistant Breast Cancer, Worldwide Innovation Networking in Personalized Cancer Medicine (WIN 9th Symposium, Expediting Global Innovation in Precision Cancer Medicine), Paris. 2017.

Researcher : Tsui WY

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Tsui YM

Project Title:	Delineating the roles of Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in Dishevelled-3 (Dvl3)-mediated cancer stemness-like properties in Hepatocellular Carcinoma (HCC)
Investigator(s):	Tsui YM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Project Title:	24th Biennial Congress of the European Association for Cancer Research; Overexpression of leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in a subset of hepatocellular carcinoma (HCC)promotes cancer stemness properties and cell migration of HCC cells
Investigator(s):	Tsui YM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Researcher : Tung KK

List of Research Outputs

Tsui Y.M., Sze M.F., Tung K.K., Ho D.W.H., Lee K.W. and Ng I.O.L., Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. , Oncotarget. 2017.

Researcher : WANG S

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Researcher : Wei L

Project Title:	AACR Annual Meeting 2017; Frequent upregulation of histone methyltransferase G9a contributed to liver carcinogenesis by epigenetically silencing of tumor suppressor RARRES3
Investigator(s):	Wei L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Wong CCL

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013
Completion Date:	04/2017

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	11/2016

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

Project Title:	Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Integrating Metabolism and Immunity; Hypoxia maintains myeloid-derived suppressor cells (MDSCs) in tumor niche through HIF-1/ENTPD2 (CD39L1)
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	06/2017

Project Title:	New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Cui C., Wong C.C.L., Kai A.K.L., Ho D.W.H., Lau Y.T., Tsui Y.M., Chan L.K., Cheung T.T., Chok K.S.H., Chan A.C.Y., Lo C.L.R., Lee M.F., Lee K.W. and Ng I.O.L., SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop, Gut. 2017, Epub ahead of print.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Wong C.C.L., Exploiting the pentose phosphate pathway as therapeutic target in hepatocellulcar carcinoma. , Cold Spring Harbor Asia: Liver Metabolism, Diseases & Cancer. . 2017.

Wong C.C.L., Folate cycle represents a new metabolic vulnerability in hepatocellular carcinoma. , Cold Spring Harbor Asia: Cancer and Metabolism. . 2016.

Wong C.C.L., Metabolic Reprogramming and Tumor Microenvironment Formation in Liver Cancer., Chinese University of Hong Kong, Department of Chemical Pathology seminar. 2016.

Wong C.C.L., Metabolic Reprogramming and Tumor Microenvironment Formation in Liver Cancer, SIgN-A*Star Immunology Seminar. Singapore. 2017.

Researcher : Wong CL

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013
Completion Date:	04/2017

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	11/2016

Project Title:	Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Identifying the Metabolic Vulnerabilities of Liver Cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	06/2016

Project Title:	Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Integrating Metabolism and Immunity; Hypoxia maintains myeloid-derived suppressor cells (MDSCs) in tumor niche through HIF-1/ENTPD2 (CD39L1)
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	06/2017

Project Title:	New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Researcher : Wong CM

Project Title:	Expression and pathological roles of linc-CHD1L-1, a novel long non-coding RNA in liver cancer
Investigator(s):	Wong CM, Tsang FH
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Clinicopathological significance and functional roles of G9a up-regulation in Hepatocellular Carcinoma
Investigator(s):	Wong CM, Wong CCL, Tsang FH
Department:	Pathology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	The roles of RNA N6-Adensoine methylation in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL, Tsang FH
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Pathological implications and functional characterizations of novel long non-coding RNA linc-CHD1L-1 in hepatocellular carcinoma
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Deregulation and somatic mutations of histone methyltransferase ASH1L in liver cancer.
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	The roles of bromodomain containing proteins in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

Project Title:	Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	03/2017

Project Title:	AACR Annual Meeting 2017; Expression and functions of ASH1L in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer
Investigator(s):	Wong CM, Tsang FH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

Kai A.K.L., Chan L.K., Lo C.L.R., Lee M.F., Wong C.C.L., Wong C.M. and Ng I.O.L., Down-regulation of TIMP2 by HIF-1alpha/miR-210/HIF-3alpha regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma, Hepatology. 2016, 64(2): 473-87.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

LEONG K.W., Cheng C.W., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression, Oncotarget. 2017.

Pong P.W.T., Wong C.M., DU Y., TENG Y., ZHENG C. and LI X., Smart Healthcare with Magnetic Nanoparticles and Spintronic Sensors, IUPAC 12th International Conference on Novel Materials and their Synthesis (NMS-XII), Changsha, China, Paper No. KL76-. 2016.

Wong C.M., Clinicopathological significance and functional roles of histone methyltransferase G9a in hepatocellular carcinoma., State Key Laboratory for Liver Research (SKLLR) Symposium 2016. Hong Kong, 2016.

Researcher : Wong GW

Project Title:	Cellular functions and potential clinical application of miR-143 in cervical cancer
Investigator(s):	Wong GW, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	06/2017

Project Title:	Identification of HNF-1β direct targets in ovarian clear cell carcinoma
Investigator(s):	Wong GW, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Chan K.K., Wong G.W. and Cheung A.N.Y., Regulation on the gene expressions of ASPP family members, In: KK Chan, Oscar GW Wong and Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4th-6th December, 2016.

Wang A.S.Y., Tse K.Y., Wong G.W., Cheung A.N.Y. and Ip P.C.P., Expression of napsin A in Arias Stella reaction: an analysis of 40 cases, 2017 United States & Canadian Academy of Pathology Annual Meeting (Modern Pathology). 2017, 30: 314A.

Wong G.W., Cheung L.Y., Chan K.K., Ip P.C.P. and Cheung A.N.Y., Impact of amyloid beta precursor protein gene APP overexpression on the cell growth and migration/invasion of Down syndrome trophoblast, In: Oscar GW Wong, Claire LY Cheung, KK Chan, Philip Ip, Annie NY Cheung, The 4th International Anatomical Sciences and Cell Biology Conference, 4-6 December 2016, Hong Kong. 2016.

Wong G.W., miR-143 targets as markers of cervical cancer, AOGIN 2016 Singapore. 2016.

Researcher : Wong KW

List of Research Outputs

Chow K.L., Tse K.Y., Cheung C.L., Wong K.W., Cheung A.N.Y., Wong W.C., Chan A.N.H., Yuen N.W.F., Ngan H.Y.S. and Ip P.C.P., The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study, Histopathology. United Kingdom, Wiley, 2017, 70: 746-755.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	02/2017

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	The role and mechanisms of Ca2+/calmodulin-dependent protein kinase II, subunit A (CaMK2A) in SOX2 upregulation in tumor initiating cells and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP, Xiao Z
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

List of Research Outputs

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	02/2017

Project Title:	The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer
Investigator(s):	Wong MP, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma
Investigator(s):	Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT, Sihoe DLA
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	The role and mechanisms of Ca2+/calmodulin-dependent protein kinase II, subunit A (CaMK2A) in SOX2 upregulation in tumor initiating cells and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer
Investigator(s):	Wong MP, Yam JWP, Xiao Z
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Kwok W.C., Lam S.H., Wong M.P., Ip M.S.M. and Lam C.L.D., Influenza B/Streptococcal co-infection complicated by organizing pneumonia, Respirology Case Reports. 2016, 4(5): e00170.

Researcher : Wong WC

List of Research Outputs

Chow K.L., Tse K.Y., Cheung C.L., Wong K.W., Cheung A.N.Y., Wong W.C., Chan A.N.H., Yuen N.W.F., Ngan H.Y.S. and Ip P.C.P., The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study, Histopathology. United Kingdom, Wiley, 2017, 70: 746-755.

Researcher : Wong WS

List of Research Outputs

Lee H.L.H., Mak A.S.L., Kou K.O.T., Poon C.F., Wong W.S., Chiu K.H., Au H.H.L., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations, Hemoglobin. 2016, 40(6): 431-434.

Researcher : XU M

List of Research Outputs

Chiu K.C., Xu M., Lai K.H., Tse P.W., Wei L., Koh H.Y., Li L.L., Lee D., Lo C.L.R., Wong C.M., Ng I.O.L. and Wong C.C.L., Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26, Hepatology. 2016, 64(3): 797-813.

Ho D.W.H., Chan L.K., Chiu Y.T., XU M., Poon R.T.P., Cheung T.T., Tang C.N., Tang V.W.L., Lo I.L.O., Lam P.W.Y., Yau D.T.W., Li M., Wong C.M. and Ng I.O.L., TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication , Gut. 2016, 66: 1496-1506.

LEE D., XU M., CHIU K.C., LAI K.H., Tse P.W., Li L.L., LAW C.T., Tsang F.H., Wei L., CHAN Y.K., Wong C.M., Ng I.O.L. and Wong C.C.L., Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma, Journal of clinical investigation. 2017, 127: 1856-1872.

Researcher : Xiao Z

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Researcher : Xu M

List of Research Outputs

Researcher : YUE SK

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Researcher : Yam JWP

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	Clinical relevance and functions of nuclear Met in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	10/2016

Project Title:	Functional role and clinical significance of galectin-1 in liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Molecular interaction of Cav1 and S100P in liver cancer metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015
Completion Date:	05/2017

Project Title:	Functional role of hypoxia-induced caveolin-1 in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	Functional role of caveolin-1-mediated S100P in liver cancer metastasis under hypoxic stress
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Functional role of exosomes in liver cancer metastasis
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Exosomes released from nuclear Met expressing cells promote liver cancer metastasis and formation of lung premetastatic niche
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Application of S100P antibody as a strategy for the treatment of liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	The interplay of Rab20 and Sec23A in the biological activities of exosomes in liver cancer
Investigator(s):	Yam JWP, Lo CLR
Department:	Pathology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Ko F.C.F., Lee K.W., Tai W.C.S., LEUNG Z. and Yam J.W.P., Functional characterization of novel tumour suppressor galectin-2 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

LEUNG Z., Ko F.C.F. and Yam J.W.P., Clinical relevance and functional role of galectin-1 in hepatocellular carcinoma, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

LIU H.M., Tey S.K. and Yam J.W.P., Rab20 and Rab30 regulate hepatocellular carcinoma (HCC) for tumor suppression, 24th Biennial Congress of the European Association for Cancer Research (EACR). 2016.

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Mao X., Guan X. and Yam J.W.P., Role of caveolin-1 in hepatitis B virus-induced hepatocarcinogenesis, Health Research Symposium 2017.

Tey S.K., Mao X. and Yam J.W.P., Exosome Released from Nuclear Met Expressing Cells Promote Liver Cancer Metastasis and Formation of Lung Prematastatic Niche, The Liver Week 2017.

Yam J.W.P., Advances in Hepatology . 2017.

Yam J.W.P., Journal of Liver: Disease & Transplantation . 2017.

Yam J.W.P., PLoS ONE, Public Libraray of Science. 2017.

Researcher : Yan HHN

Project Title:	Regulation of stromal miR125b on normal colonic epithelial cell renewal and tumorigenesis
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Intestinal organoid cultures of early onset colorectal cancers
Investigator(s):	Yan HHN, Leung SY, Law WL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Characterization of gastric intestinal metaplasia and its role in gastric cancer progression
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2016

Project Title:	American Association for Cancer Research Annual Meeting 2017; Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation
Investigator(s):	Yan HHN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Use of whole genome sequencing to unveil new mechanisms of germline DNA mismatch repair gene alterations in Lynch Syndrome patients
Investigator(s):	Yan HHN, Leung SY, Siu HC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

List of Research Outputs

YUE S.K., Yan H.H.N., Siu H.C., Ho R.S.L., Tsui W.Y., Chan D., Chan A.S.Y., Lee C.H., Chan K.W. and Leung S.Y., Gastric cancer organoid culture shows preserved genomic stability in long-term passage, AACR 2017 Annual Meeting. http://cancerres.aacrjournals.org/content/77/13_Supplement/4378. 2017.

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

Researcher : Yeung YS

List of Research Outputs

Mao X., Wong S.Y., Tse E.Y., Ko F.C.F., Tey S.K., Yeung Y.S., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma, Cancer Research. 2016, Epub ahead of print.

Researcher : Yuen ST

List of Research Outputs

Yan H.H.N., Lai C.W.J., Ho R.S.L., Chan K.W., Tsui W.Y., Chan A.S.Y., Yuen S.T. and Leung S.Y., Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation, AACR 2017 Annual Meeting. 2017. http://cancerres.aacrjournals.org/content/77/13_Supplement/1448. 2017.

Researcher : Zhao F

Project Title:	Role of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in breast cancer tumorigenesis
Investigator(s):	Zhao F, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

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